locus-tag	class	description
sps_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
sps_RS00010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
sps_RS00020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
sps_RS00025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
sps_RS00035	COG1845	cytochrome c oxidase, subunit III
sps_RS00050	COG4221	oxidoreductase activity
sps_RS00070	COG3214	Protein conserved in bacteria
sps_RS00075	COG0653	protein targeting
sps_RS00080	COG4115	mRNA cleavage
sps_RS00085	COG2161	toxin-antitoxin pair type II binding
sps_RS00090	COG0270	DNA (cytosine-5-)-methyltransferase activity
sps_RS00110	COG3328	transposase activity
sps_RS00140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
sps_RS00155	COG1643	Atp-dependent helicase
sps_RS00165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
sps_RS00170	COG0706	membrane insertase activity
sps_RS00175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
sps_RS00180	COG0594	ribonuclease P activity
sps_RS00190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
sps_RS00200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
sps_RS00205	COG0187	DNA topoisomerase II activity
sps_RS00235	COG1984	allophanate hydrolase subunit 2
sps_RS00240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
sps_RS00250	COG0751	glycine-tRNA ligase activity
sps_RS00255	COG0752	glycyl-tRNA synthetase alpha subunit
sps_RS00260	COG2818	Glycosylase
sps_RS00270	COG1506	peptidase
sps_RS00270	COG0823	Involved in the tonB-independent uptake of proteins
sps_RS00270	COG4946	Tricorn protease homolog
sps_RS00280	COG0425	Belongs to the sulfur carrier protein TusA family
sps_RS00285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
sps_RS00295	COG0183	Belongs to the thiolase family
sps_RS00300	COG1250	3-hydroxyacyl-CoA dehydrogenase
sps_RS00300	COG1024	Enoyl-CoA hydratase
sps_RS00305	COG0006	proline dipeptidase activity
sps_RS00310	COG1739	Uncharacterized protein family UPF0029
sps_RS00315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
sps_RS00320	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
sps_RS00325	COG0640	Transcriptional regulator
sps_RS00345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
sps_RS00350	COG0569	domain protein
sps_RS00355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
sps_RS00355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
sps_RS00360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
sps_RS00365	COG0242	peptide deformylase activity
sps_RS00375	COG0758	DNA mediated transformation
sps_RS00380	COG2922	Belongs to the Smg family
sps_RS00385	COG3291	Pkd domain containing protein
sps_RS00395	COG0009	L-threonylcarbamoyladenylate synthase
sps_RS00400	COG0408	coproporphyrinogen oxidase activity
sps_RS00410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
sps_RS00420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
sps_RS00455	COG1360	Flagellar Motor Protein
sps_RS00460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
sps_RS00465	COG1191	sigma factor activity
sps_RS00470	COG1580	Controls the rotational direction of flagella during chemotaxis
sps_RS00490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
sps_RS00495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
sps_RS00515	COG3951	Flagellar rod assembly protein muramidase FlgJ
sps_RS00515	COG1705	Flagellar rod assembly protein muramidase FlgJ
sps_RS00520	COG1706	bacterial-type flagellum-dependent cell motility
sps_RS00525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
sps_RS00530	COG4786	Flagellar basal body rod
sps_RS00535	COG4787	bacterial-type flagellum-dependent cell motility
sps_RS00540	COG1749	Flagellar hook protein flgE
sps_RS00545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
sps_RS00550	COG1558	bacterial-type flagellum-dependent cell motility
sps_RS00555	COG1815	bacterial-type flagellum-dependent cell motility
sps_RS00620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
sps_RS00640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
sps_RS00650	COG2267	carboxylic ester hydrolase activity
sps_RS00660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
sps_RS00670	COG3078	GTPase activator activity
sps_RS00685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
sps_RS00690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
sps_RS00690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
sps_RS00695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
sps_RS00705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
sps_RS00710	COG1063	alcohol dehydrogenase
sps_RS00725	COG1519	Transferase
sps_RS00730	COG3642	lipopolysaccharide core region biosynthetic process
sps_RS00735	COG1091	dTDP-4-dehydrorhamnose reductase activity
sps_RS00755	COG0859	PFAM glycosyl transferase family 9
sps_RS00775	COG3306	glycosyltransferase involved in LPS biosynthesis
sps_RS00800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
sps_RS00805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
sps_RS00805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
sps_RS00810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
sps_RS00820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
sps_RS00830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
sps_RS00835	COG0303	'Molybdopterin
sps_RS00840	COG0746	molybdenum cofactor guanylyltransferase activity
sps_RS00845	COG1136	(ABC) transporter
sps_RS00860	COG2204	response regulator
sps_RS00865	COG3852	Histidine kinase
sps_RS00870	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
sps_RS00880	COG1169	isochorismate synthase
sps_RS00895	COG2855	membrane
sps_RS00900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
sps_RS00915	COG0339	signal peptide processing
sps_RS00950	COG2814	Major facilitator Superfamily
sps_RS00955	COG0583	DNA-binding transcription factor activity
sps_RS00965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS00970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS00980	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
sps_RS00990	COG2366	antibiotic biosynthetic process
sps_RS00995	COG1704	LemA family
sps_RS01005	COG1196	nuclear chromosome segregation
sps_RS01005	COG0741	lytic transglycosylase activity
sps_RS01005	COG0739	heme binding
sps_RS01015	COG0583	DNA-binding transcription factor activity
sps_RS01025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
sps_RS01030	COG0742	ribosomal rna small subunit methyltransferase
sps_RS01040	COG2197	response regulator
sps_RS01050	COG3916	Acyl-homoserine-lactone synthase
sps_RS01055	COG2977	Belongs to the P-Pant transferase superfamily
sps_RS01060	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
sps_RS01075	COG0508	dehydrogenase complex catalyzes the overall conversion of
sps_RS01095	COG3321	synthase
sps_RS01095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sps_RS01100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
sps_RS01100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
sps_RS01100	COG3321	synthase
sps_RS01100	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
sps_RS01115	COG0318	PFAM AMP-dependent synthetase and ligase
sps_RS01120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
sps_RS01130	COG1566	PFAM secretion protein HlyD family protein
sps_RS01135	COG0678	peroxiredoxin activity
sps_RS01165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
sps_RS01175	COG2183	response to ionizing radiation
sps_RS01180	COG1368	sulfuric ester hydrolase activity
sps_RS01190	COG0596	Alpha beta hydrolase
sps_RS01195	COG1040	competence protein
sps_RS01205	COG0316	Belongs to the HesB IscA family
sps_RS01205	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
sps_RS01210	COG0534	Mate efflux family protein
sps_RS01215	COG0726	polysaccharide deacetylase
sps_RS01220	COG2201	protein-glutamate methylesterase activity
sps_RS01225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
sps_RS01230	COG0840	transmembrane signaling receptor activity
sps_RS01235	COG0835	chemotaxis
sps_RS01240	COG0643	Histidine kinase
sps_RS01240	COG2198	Histidine kinase
sps_RS01245	COG0745	RESPONSE REGULATOR receiver
sps_RS01255	COG1999	signal sequence binding
sps_RS01260	COG0109	protoheme IX farnesyltransferase activity
sps_RS01265	COG1612	heme a metabolic process
sps_RS01290	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
sps_RS01295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
sps_RS01300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
sps_RS01310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
sps_RS01315	COG2937	Belongs to the GPAT DAPAT family
sps_RS01320	COG0814	amino acid
sps_RS01325	COG0778	Nitroreductase
sps_RS01340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS01350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
sps_RS01350	COG1017	nitric oxide dioxygenase activity
sps_RS01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS01395	COG3005	denitrification pathway
sps_RS01400	COG2207	Transcriptional regulator
sps_RS01400	COG3708	Transcriptional regulator
sps_RS01415	COG1120	ATPase activity
sps_RS01420	COG4607	ABC-type enterochelin transport system periplasmic component
sps_RS01445	COG0742	ribosomal rna small subunit methyltransferase
sps_RS01450	COG0552	protein localization to endoplasmic reticulum
sps_RS01455	COG2884	Cell division ATP-binding protein ftsE
sps_RS01460	COG2177	Part of the ABC transporter FtsEX involved in
sps_RS01480	COG0596	Alpha beta hydrolase
sps_RS01485	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
sps_RS01495	COG0531	amino acid
sps_RS01550	COG5001	Diguanylate cyclase
sps_RS01550	COG1716	ATPase activity
sps_RS01555	COG2200	EAL domain
sps_RS01570	COG0612	Peptidase, M16
sps_RS01590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
sps_RS01595	COG0583	DNA-binding transcription factor activity
sps_RS01600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
sps_RS01605	COG1328	CTP reductase activity
sps_RS01615	COG3284	Transcriptional regulator
sps_RS01620	COG0753	catalase activity
sps_RS01625	COG3568	Endonuclease Exonuclease Phosphatase
sps_RS01640	COG0604	alcohol dehydrogenase
sps_RS01665	COG2205	protein histidine kinase activity
sps_RS01670	COG0745	RESPONSE REGULATOR receiver
sps_RS01705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
sps_RS01715	COG1072	(Pantothenic acid kinase))
sps_RS01735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
sps_RS01750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
sps_RS01755	COG0081	regulation of translation
sps_RS01760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
sps_RS01765	COG0222	ribosome binding
sps_RS01780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
sps_RS01785	COG0049	tRNA binding
sps_RS01800	COG0051	transcription antitermination factor activity, RNA binding
sps_RS01805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
sps_RS01810	COG0088	Forms part of the polypeptide exit tunnel
sps_RS01815	COG0089	rRNA binding
sps_RS01820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
sps_RS01825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
sps_RS01830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
sps_RS01835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
sps_RS01840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
sps_RS01845	COG0255	Belongs to the universal ribosomal protein uL29 family
sps_RS01850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
sps_RS01855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
sps_RS01865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
sps_RS01870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
sps_RS01875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
sps_RS01880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
sps_RS01885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
sps_RS01890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
sps_RS01895	COG1841	ribosomal large subunit assembly
sps_RS01900	COG0200	Binds to the 23S rRNA
sps_RS01905	COG0201	protein transport
sps_RS01915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
sps_RS01920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
sps_RS01925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
sps_RS01930	COG0202	RNA polymerase activity
sps_RS01935	COG0203	ribosomal protein L17
sps_RS01945	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
sps_RS01950	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
sps_RS01955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
sps_RS01960	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
sps_RS01975	COG3088	subunit of a heme lyase
sps_RS01975	COG4235	cytochrome complex assembly
sps_RS01995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
sps_RS02030	COG4667	esterase of the alpha-beta hydrolase superfamily
sps_RS02035	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
sps_RS02055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
sps_RS02080	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
sps_RS02090	COG3639	organic phosphonate transmembrane transporter activity
sps_RS02110	COG2204	response regulator
sps_RS02115	COG2239	Acts as a magnesium transporter
sps_RS02125	COG1280	lysine exporter protein (LysE YggA)
sps_RS02135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
sps_RS02150	COG3706	GGDEF domain
sps_RS02160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
sps_RS02165	COG0488	(ABC) transporter
sps_RS02185	COG3082	Protein of unknown function (DUF1414)
sps_RS02190	COG3081	Nucleoid-associated protein
sps_RS02215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
sps_RS02235	COG0784	Response regulator, receiver
sps_RS02235	COG2205	protein histidine kinase activity
sps_RS02270	COG0454	-acetyltransferase
sps_RS02280	COG4774	siderophore transport
sps_RS02285	COG3102	Protein conserved in bacteria
sps_RS02295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
sps_RS02360	COG0367	asparagine synthase
sps_RS02370	COG0647	UMP catabolic process
sps_RS02375	COG2610	gluconate transmembrane transporter activity
sps_RS02380	COG3265	gluconokinase activity
sps_RS02385	COG0589	response to stress
sps_RS02390	COG1863	multisubunit Na H antiporter MnhE subunit
sps_RS02400	COG1320	monovalent cation:proton antiporter activity
sps_RS02410	COG1006	Multisubunit Na H antiporter MnhC subunit
sps_RS02415	COG0651	ATP synthesis coupled electron transport
sps_RS02420	COG0651	ATP synthesis coupled electron transport
sps_RS02430	COG0651	ATP synthesis coupled electron transport
sps_RS02440	COG2137	regulation of response to DNA damage stimulus
sps_RS02445	COG1609	Transcriptional regulator
sps_RS02450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
sps_RS02455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
sps_RS02460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
sps_RS02465	COG2056	Na+-H+ antiporter family
sps_RS02470	COG0450	alkyl hydroperoxide reductase
sps_RS02480	COG2885	chlorophyll binding
sps_RS02485	COG1505	serine-type exopeptidase activity
sps_RS02490	COG0824	Thioesterase
sps_RS02495	COG0811	peptide transport
sps_RS02510	COG0823	Involved in the tonB-independent uptake of proteins
sps_RS02515	COG2885	chlorophyll binding
sps_RS02520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
sps_RS02565	COG1061	Type III restriction enzyme res subunit
sps_RS02570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
sps_RS02575	COG2205	protein histidine kinase activity
sps_RS02580	COG0179	Fumarylacetoacetate (FAA) hydrolase
sps_RS02585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
sps_RS02595	COG1607	acyl-coa hydrolase
sps_RS02615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
sps_RS02620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
sps_RS02625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
sps_RS02625	COG0574	Belongs to the PEP-utilizing enzyme family
sps_RS02630	COG0277	FAD linked oxidase domain protein
sps_RS02630	COG0247	lactate metabolic process
sps_RS02695	COG3436	PFAM IS66 Orf2 family protein
sps_RS02705	COG3328	transposase activity
sps_RS02725	COG2850	peptidyl-arginine hydroxylation
sps_RS02730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
sps_RS02735	COG2915	High frequency lysogenization protein hflD homolog
sps_RS02740	COG0482	sulfurtransferase activity
sps_RS02760	COG1278	Cold shock
sps_RS02765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
sps_RS02770	COG0542	response to heat
sps_RS02775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
sps_RS02780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
sps_RS02785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
sps_RS02790	COG3134	Outer membrane lipoprotein
sps_RS02800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
sps_RS02815	COG0626	cystathionine gamma-synthase activity
sps_RS02820	COG2205	protein histidine kinase activity
sps_RS02825	COG0745	RESPONSE REGULATOR receiver
sps_RS02845	COG3706	GGDEF domain
sps_RS02850	COG3008	intermembrane lipid transfer
sps_RS02855	COG2995	paraquat-inducible protein a
sps_RS02860	COG2995	paraquat-inducible protein a
sps_RS02865	COG3141	response to X-ray
sps_RS02870	COG1956	GAF domain-containing protein
sps_RS02875	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
sps_RS02880	COG0793	Belongs to the peptidase S41A family
sps_RS02885	COG0308	aminopeptidase N
sps_RS02905	COG4447	cellulose binding
sps_RS02920	COG0167	dihydroorotate dehydrogenase activity
sps_RS02930	COG0116	Belongs to the methyltransferase superfamily
sps_RS02930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
sps_RS02940	COG0488	(ABC) transporter
sps_RS02950	COG3130	regulation of translation
sps_RS02955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
sps_RS02960	COG1067	ATP-dependent peptidase activity
sps_RS02970	COG2197	response regulator
sps_RS02975	COG0322	excinuclease ABC activity
sps_RS03005	COG5001	Diguanylate cyclase
sps_RS03005	COG3300	MHYT domain
sps_RS03015	COG2989	Protein conserved in bacteria
sps_RS03020	COG3108	Peptidase M15
sps_RS03025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
sps_RS03030	COG2719	SpoVR family
sps_RS03035	COG2718	Belongs to the UPF0229 family
sps_RS03040	COG2766	serine protein kinase
sps_RS03080	COG1393	Belongs to the ArsC family
sps_RS03085	COG4783	chaperone-mediated protein folding
sps_RS03110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
sps_RS03115	COG2716	regulation of RNA biosynthetic process
sps_RS03120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
sps_RS03125	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
sps_RS03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS03160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
sps_RS03170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
sps_RS03175	COG1454	alcohol dehydrogenase
sps_RS03180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
sps_RS03185	COG0288	reversible hydration of carbon dioxide
sps_RS03200	COG0596	Alpha beta hydrolase
sps_RS03205	COG1876	peptidase activity
sps_RS03210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
sps_RS03215	COG1393	Belongs to the ArsC family
sps_RS03225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
sps_RS03230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
sps_RS03250	COG2176	DNA-directed DNA polymerase activity
sps_RS03255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
sps_RS03260	COG2850	peptidyl-arginine hydroxylation
sps_RS03305	COG0697	spore germination
sps_RS03310	COG0346	lactoylglutathione lyase activity
sps_RS03320	COG2808	Putative FMN-binding domain
sps_RS03345	COG5433	transposase activity
sps_RS03350	COG4221	oxidoreductase activity
sps_RS03355	COG0393	Putative heavy-metal-binding
sps_RS03365	COG0569	domain protein
sps_RS03370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
sps_RS03385	COG1115	amino acid carrier protein
sps_RS03395	COG1760	l-serine dehydratase
sps_RS03400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
sps_RS03405	COG0509	glycine decarboxylation via glycine cleavage system
sps_RS03410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
sps_RS03410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
sps_RS03425	COG1757	Na H antiporter
sps_RS03430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
sps_RS03460	COG2207	Transcriptional regulator
sps_RS03465	COG2807	transmembrane transport
sps_RS03470	COG0513	Belongs to the DEAD box helicase family
sps_RS03480	COG0366	Alpha amylase catalytic
sps_RS03490	COG0366	Alpha amylase catalytic
sps_RS03500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
sps_RS03500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
sps_RS03515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
sps_RS03520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
sps_RS03530	COG3706	GGDEF domain
sps_RS03570	COG3706	GGDEF domain
sps_RS03580	COG0463	Glycosyl transferase, family 2
sps_RS03610	COG2989	Protein conserved in bacteria
sps_RS03640	COG4964	Belongs to the GSP D family
sps_RS03690	COG0017	Asparaginyl-tRNA synthetase
sps_RS03705	COG0494	nUDIX hydrolase
sps_RS03710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
sps_RS03720	COG0823	Involved in the tonB-independent uptake of proteins
sps_RS03720	COG1506	peptidase
sps_RS03755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
sps_RS03765	COG1454	alcohol dehydrogenase
sps_RS03765	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS03770	COG2095	MarC family integral membrane protein
sps_RS03795	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
sps_RS03805	COG0436	Aminotransferase
sps_RS03810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
sps_RS03835	COG0596	Alpha beta hydrolase
sps_RS03840	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
sps_RS03845	COG0033	Phosphoglucomutase
sps_RS03850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
sps_RS03855	COG2988	succinylglutamate desuccinylase activity
sps_RS03865	COG0022	dehydrogenase e1 component
sps_RS03880	COG0840	transmembrane signaling receptor activity
sps_RS03905	COG0514	ATP-dependent DNA helicase (RecQ)
sps_RS03915	COG0745	RESPONSE REGULATOR receiver
sps_RS03920	COG2866	Carboxypeptidase
sps_RS03930	COG3139	Protein of unknown function (DUF1315)
sps_RS03935	COG0252	asparaginase activity
sps_RS03940	COG0616	signal peptide processing
sps_RS03945	COG1902	pentaerythritol trinitrate reductase activity
sps_RS03945	COG0446	pyridine nucleotide-disulphide oxidoreductase
sps_RS03950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
sps_RS03955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
sps_RS03965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
sps_RS03975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
sps_RS03985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
sps_RS03990	COG1448	Aminotransferase
sps_RS03995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
sps_RS04000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
sps_RS04005	COG0539	negative regulation of cytoplasmic translation
sps_RS04010	COG0776	regulation of translation
sps_RS04020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
sps_RS04025	COG0284	orotidine-5'-phosphate decarboxylase activity
sps_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS04035	COG3122	Protein conserved in bacteria
sps_RS04040	COG1960	acyl-CoA dehydrogenase activity
sps_RS04045	COG2027	D-alanyl-D-alanine carboxypeptidase
sps_RS04060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
sps_RS04065	COG2814	Major facilitator Superfamily
sps_RS04070	COG3148	PFAM DTW domain containing protein
sps_RS04110	COG0784	Response regulator, receiver
sps_RS04110	COG2205	protein histidine kinase activity
sps_RS04130	COG2814	Major facilitator Superfamily
sps_RS04135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
sps_RS04245	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
sps_RS04250	COG0210	DNA helicase
sps_RS04260	COG0583	DNA-binding transcription factor activity
sps_RS04270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
sps_RS04275	COG0583	DNA-binding transcription factor activity
sps_RS04280	COG0583	DNA-binding transcription factor activity
sps_RS04305	COG0488	(ABC) transporter
sps_RS04310	COG1335	isochorismatase
sps_RS04315	COG0318	PFAM AMP-dependent synthetase and ligase
sps_RS04320	COG3706	GGDEF domain
sps_RS04325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sps_RS04330	COG1404	Belongs to the peptidase S8 family
sps_RS04340	COG0564	pseudouridine synthase activity
sps_RS04395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
sps_RS04415	COG2193	ferroxidase activity
sps_RS04425	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
sps_RS04435	COG3706	GGDEF domain
sps_RS04450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
sps_RS04490	COG1448	Aminotransferase
sps_RS04500	COG2992	FlgJ-related protein
sps_RS04510	COG0037	tRNA processing
sps_RS04515	COG0589	response to stress
sps_RS04520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
sps_RS04535	COG2217	Heavy metal translocating P-type atpase
sps_RS04545	COG2010	Cytochrome c
sps_RS04560	COG3278	Belongs to the heme-copper respiratory oxidase family
sps_RS04570	COG0784	Response regulator, receiver
sps_RS04570	COG3437	response regulator, receiver
sps_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS04660	COG3328	transposase activity
sps_RS04690	COG3486	L-lysine 6-monooxygenase (NADPH) activity
sps_RS04695	COG3486	L-lysine 6-monooxygenase (NADPH) activity
sps_RS04705	COG1063	alcohol dehydrogenase
sps_RS04735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS04735	COG4191	Histidine kinase
sps_RS04740	COG2072	flavoprotein involved in K transport
sps_RS04755	COG5001	Diguanylate cyclase
sps_RS04755	COG4251	negative regulation of phosphorylation
sps_RS04755	COG2203	Gaf domain
sps_RS04755	COG3706	GGDEF domain
sps_RS04760	COG1027	Aspartate ammonia-lyase
sps_RS04770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
sps_RS04780	COG0583	DNA-binding transcription factor activity
sps_RS04785	COG3706	GGDEF domain
sps_RS04810	COG1067	ATP-dependent peptidase activity
sps_RS04930	COG2207	Transcriptional regulator
sps_RS05010	COG1404	Belongs to the peptidase S8 family
sps_RS05020	COG3436	PFAM IS66 Orf2 family protein
sps_RS05035	COG5002	protein histidine kinase activity
sps_RS05035	COG0784	Response regulator, receiver
sps_RS05035	COG2205	protein histidine kinase activity
sps_RS05045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
sps_RS05065	COG3209	COG3209 Rhs family protein
sps_RS05120	COG4104	PAAR repeat-containing protein
sps_RS05125	COG3501	Rhs element vgr protein
sps_RS05155	COG3829	transcription factor binding
sps_RS05215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS05220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS05235	COG2814	Major facilitator Superfamily
sps_RS05240	COG0583	DNA-binding transcription factor activity
sps_RS05245	COG0670	Belongs to the BI1 family
sps_RS05250	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
sps_RS05255	COG2923	Belongs to the DsrF TusC family
sps_RS05260	COG2168	tRNA wobble position uridine thiolation
sps_RS05265	COG2920	part of a sulfur-relay system
sps_RS05270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
sps_RS05275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
sps_RS05280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
sps_RS05285	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
sps_RS05290	COG1674	ftsk spoiiie
sps_RS05290	COG0531	amino acid
sps_RS05300	COG0686	Belongs to the AlaDH PNT family
sps_RS05305	COG0492	ferredoxin-NADP+ reductase activity
sps_RS05310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
sps_RS05320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
sps_RS05325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
sps_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS05345	COG0307	riboflavin synthase, alpha
sps_RS05350	COG0534	Mate efflux family protein
sps_RS05380	COG0281	malic enzyme
sps_RS05390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
sps_RS05395	COG2252	PERMEase
sps_RS05410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
sps_RS05415	COG3616	Alanine racemase, N-terminal domain
sps_RS05420	COG2423	ornithine cyclodeaminase activity
sps_RS05425	COG3385	transposase activity
sps_RS05435	COG4413	Urea transporter
sps_RS05440	COG1309	transcriptional regulator
sps_RS05450	COG0402	S-adenosylhomocysteine deaminase activity
sps_RS05470	COG4266	Belongs to the allantoicase family
sps_RS05480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
sps_RS05490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sps_RS05490	COG1042	CoA-binding domain protein
sps_RS05490	COG0045	succinate-CoA ligase (ADP-forming) activity
sps_RS05500	COG2194	sulfuric ester hydrolase activity
sps_RS05515	COG0673	inositol 2-dehydrogenase activity
sps_RS05520	COG0800	Aldolase
sps_RS05525	COG0129	dihydroxy-acid dehydratase activity
sps_RS05530	COG0363	glucosamine-6-phosphate deaminase activity
sps_RS05535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
sps_RS05540	COG1737	Transcriptional regulator
sps_RS05545	COG0469	pyruvate kinase activity
sps_RS05550	COG1960	acyl-CoA dehydrogenase activity
sps_RS05570	COG3012	SEC-C Motif Domain Protein
sps_RS05615	COG0602	queuosine metabolic process
sps_RS05620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
sps_RS05630	COG0556	nucleotide-excision repair
sps_RS05670	COG4657	Part of a membrane complex involved in electron transport
sps_RS05675	COG2878	Part of a membrane complex involved in electron transport
sps_RS05680	COG4656	Part of a membrane complex involved in electron transport
sps_RS05685	COG4658	electron transport chain
sps_RS05690	COG4659	FMN binding
sps_RS05695	COG4660	Part of a membrane complex involved in electron transport
sps_RS05700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
sps_RS05705	COG0346	lactoylglutathione lyase activity
sps_RS05740	COG2255	four-way junction helicase activity
sps_RS05745	COG0632	four-way junction helicase activity
sps_RS05750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
sps_RS05755	COG0217	transcriptional regulatory protein
sps_RS05760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
sps_RS05770	COG2226	methyltransferase
sps_RS05775	COG0500	methyltransferase
sps_RS05780	COG4067	protein conserved in archaea
sps_RS05780	COG0189	ligase activity
sps_RS05820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
sps_RS05825	COG2022	thiamine diphosphate biosynthetic process
sps_RS05835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
sps_RS05845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
sps_RS05855	COG1272	protein, Hemolysin III
sps_RS05870	COG0242	peptide deformylase activity
sps_RS05890	COG0121	glutamine amidotransferase
sps_RS05895	COG1960	acyl-CoA dehydrogenase activity
sps_RS05930	COG0328	RNA-DNA hybrid ribonuclease activity
sps_RS05935	COG0583	DNA-binding transcription factor activity
sps_RS05940	COG2226	methyltransferase
sps_RS05945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
sps_RS05950	COG0741	lytic transglycosylase activity
sps_RS05950	COG1388	LysM domain
sps_RS05965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
sps_RS05975	COG0840	transmembrane signaling receptor activity
sps_RS05985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
sps_RS05990	COG1322	Protein conserved in bacteria
sps_RS05995	COG0741	lytic transglycosylase activity
sps_RS06005	COG0714	Associated with various cellular activities
sps_RS06050	COG0739	heme binding
sps_RS06060	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
sps_RS06065	COG1074	ATP-dependent DNA helicase activity
sps_RS06070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
sps_RS06085	COG3328	transposase activity
sps_RS06105	COG5433	transposase activity
sps_RS06125	COG3655	Transcriptional regulator
sps_RS06135	COG1280	lysine exporter protein (LysE YggA)
sps_RS06140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
sps_RS06170	COG1181	Belongs to the D-alanine--D-alanine ligase family
sps_RS06195	COG3005	denitrification pathway
sps_RS06205	COG0243	molybdopterin cofactor binding
sps_RS06215	COG1643	Atp-dependent helicase
sps_RS06220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
sps_RS06225	COG0402	S-adenosylhomocysteine deaminase activity
sps_RS06240	COG3038	cytochrome b561
sps_RS06265	COG0517	IMP dehydrogenase activity
sps_RS06265	COG1125	glycine betaine transport
sps_RS06270	COG1280	lysine exporter protein (LysE YggA)
sps_RS06285	COG0729	surface antigen
sps_RS06290	COG2911	Protein conserved in bacteria
sps_RS06295	COG2031	fatty acid transporter
sps_RS06300	COG2186	Transcriptional regulator
sps_RS06305	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
sps_RS06310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
sps_RS06315	COG3385	transposase activity
sps_RS06320	COG2983	Belongs to the UPF0260 family
sps_RS06330	COG3100	YcgL domain-containing protein
sps_RS06335	COG0850	regulation of cytokinetic process
sps_RS06340	COG2894	cell division
sps_RS06345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
sps_RS06350	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
sps_RS06355	COG0318	PFAM AMP-dependent synthetase and ligase
sps_RS06380	COG1214	PFAM Peptidase M22, glycoprotease
sps_RS06385	COG0519	Catalyzes the synthesis of GMP from XMP
sps_RS06395	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS06400	COG0174	glutamine synthetase
sps_RS06405	COG0531	amino acid
sps_RS06410	COG0583	DNA-binding transcription factor activity
sps_RS06415	COG1252	NADH dehydrogenase
sps_RS06420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS06420	COG4191	Histidine kinase
sps_RS06430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
sps_RS06445	COG1199	ATP-dependent helicase activity
sps_RS06455	COG2964	Protein conserved in bacteria
sps_RS06460	COG3681	Belongs to the UPF0597 family
sps_RS06490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
sps_RS06495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
sps_RS06500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
sps_RS06505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
sps_RS06505	COG0131	Imidazoleglycerol-phosphate dehydratase
sps_RS06510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
sps_RS06515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
sps_RS06520	COG0107	imidazoleglycerol-phosphate synthase activity
sps_RS06525	COG0140	phosphoribosyl-ATP diphosphatase activity
sps_RS06525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
sps_RS06535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
sps_RS06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sps_RS06550	COG0776	regulation of translation
sps_RS06555	COG0072	phenylalanine-tRNA ligase activity
sps_RS06555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
sps_RS06560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
sps_RS06610	COG0259	pyridoxamine-phosphate oxidase activity
sps_RS06615	COG0010	Belongs to the arginase family
sps_RS06625	COG1166	arginine decarboxylase activity
sps_RS06635	COG3132	Protein of unknown function, DUF480
sps_RS06645	COG1131	(ABC) transporter
sps_RS06650	COG1278	Cold shock
sps_RS06655	COG2226	methyltransferase
sps_RS06680	COG2925	Exonuclease
sps_RS06685	COG0295	cytidine deaminase activity
sps_RS06690	COG2084	Dehydrogenase
sps_RS06705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
sps_RS06710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
sps_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS06720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
sps_RS06730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
sps_RS06735	COG1399	metal-binding, possibly nucleic acid-binding protein
sps_RS06740	COG0424	maF-like protein
sps_RS06750	COG0546	phosphoglycolate phosphatase activity
sps_RS06760	COG1530	ribonuclease E activity
sps_RS06765	COG0659	secondary active sulfate transmembrane transporter activity
sps_RS06770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
sps_RS06780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
sps_RS06785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
sps_RS06790	COG1793	dna ligase
sps_RS06795	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
sps_RS06810	COG2715	membrane protein required for spore maturation
sps_RS06815	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
sps_RS06815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
sps_RS06820	COG0084	hydrolase, TatD family'
sps_RS06835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
sps_RS06840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
sps_RS06845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
sps_RS06850	COG0572	uridine kinase
sps_RS06860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
sps_RS06860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
sps_RS06865	COG2897	thiosulfate sulfurtransferase activity
sps_RS06870	COG0456	acetyltransferase
sps_RS06885	COG0443	Heat shock 70 kDa protein
sps_RS06890	COG0442	prolyl-tRNA aminoacylation
sps_RS06895	COG1030	water channel activity
sps_RS06900	COG0330	HflC and HflK could
sps_RS06905	COG1054	Belongs to the UPF0176 family
sps_RS06925	COG2814	Major facilitator Superfamily
sps_RS06930	COG0028	Belongs to the TPP enzyme family
sps_RS06935	COG0440	acetolactate synthase activity
sps_RS06950	COG0737	Belongs to the 5'-nucleotidase family
sps_RS06955	COG0400	carboxylic ester hydrolase activity
sps_RS06960	COG0435	Glutathione S-transferase
sps_RS06980	COG2951	lytic endotransglycosylase activity
sps_RS06995	COG0835	chemotaxis
sps_RS06995	COG0784	Response regulator, receiver
sps_RS07000	COG0668	transmembrane transport
sps_RS07025	COG1858	cytochrome C peroxidase
sps_RS07045	COG1280	lysine exporter protein (LysE YggA)
sps_RS07055	COG0405	Gamma-glutamyltransferase
sps_RS07060	COG0339	signal peptide processing
sps_RS07070	COG3328	transposase activity
sps_RS07170	COG3436	PFAM IS66 Orf2 family protein
sps_RS07175	COG4372	Transposase
sps_RS07180	COG3385	transposase activity
sps_RS07235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
sps_RS07345	COG0384	phenazine biosynthesis protein PhzF
sps_RS07360	COG3033	Beta-eliminating lyase
sps_RS07375	COG2205	protein histidine kinase activity
sps_RS07380	COG0745	RESPONSE REGULATOR receiver
sps_RS07435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
sps_RS07450	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
sps_RS07465	COG0840	transmembrane signaling receptor activity
sps_RS07485	COG1881	PFAM PEBP family protein
sps_RS07490	COG1960	acyl-CoA dehydrogenase activity
sps_RS07495	COG0676	glucose-6-phosphate 1-epimerase activity
sps_RS07515	COG3291	Pkd domain containing protein
sps_RS07520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
sps_RS07530	COG0113	porphobilinogen synthase activity
sps_RS07540	COG1794	racemase activity, acting on amino acids and derivatives
sps_RS07605	COG1429	ligase activity, forming nitrogen-metal bonds
sps_RS07615	COG1136	(ABC) transporter
sps_RS07615	COG0577	efflux transmembrane transporter activity
sps_RS07635	COG1136	(ABC) transporter
sps_RS07655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sps_RS07670	COG0778	Nitroreductase
sps_RS07695	COG4773	Receptor
sps_RS07710	COG0537	adenosine 5'-monophosphoramidase activity
sps_RS07715	COG1309	transcriptional regulator
sps_RS07720	COG3111	PFAM Bacterial OB fold (BOF) protein
sps_RS07760	COG2197	response regulator
sps_RS07785	COG2815	serine threonine protein kinase
sps_RS07785	COG0515	serine threonine protein kinase
sps_RS07790	COG2223	nitrite transmembrane transporter activity
sps_RS07800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
sps_RS07800	COG2146	nitrite reductase [NAD(P)H] activity
sps_RS07810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
sps_RS07815	COG1648	precorrin-2 dehydrogenase activity
sps_RS07815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
sps_RS07825	COG1053	succinate dehydrogenase
sps_RS07830	COG0501	Belongs to the peptidase M48B family
sps_RS07840	COG0339	signal peptide processing
sps_RS07850	COG2226	methyltransferase
sps_RS07860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
sps_RS07890	COG0437	4 iron, 4 sulfur cluster binding
sps_RS07895	COG0243	molybdopterin cofactor binding
sps_RS07900	COG4574	serine-type endopeptidase inhibitor activity
sps_RS07940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
sps_RS07945	COG0735	belongs to the Fur family
sps_RS07955	COG0069	glutamate synthase activity
sps_RS07965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
sps_RS07970	COG0045	succinate-CoA ligase (ADP-forming) activity
sps_RS07975	COG0508	dehydrogenase complex catalyzes the overall conversion of
sps_RS07980	COG0567	Dehydrogenase, E1 component
sps_RS07985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
sps_RS07990	COG1053	succinate dehydrogenase
sps_RS07995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
sps_RS08010	COG0454	-acetyltransferase
sps_RS08020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS08045	COG0515	serine threonine protein kinase
sps_RS08050	COG2835	tetraacyldisaccharide 4'-kinase activity
sps_RS08055	COG1663	tetraacyldisaccharide 4'-kinase activity
sps_RS08060	COG1132	(ABC) transporter
sps_RS08065	COG2333	competence protein COMEC
sps_RS08065	COG0658	competence protein
sps_RS08080	COG4591	ABC-type transport system involved in lipoprotein release permease component
sps_RS08090	COG4591	ABC-type transport system involved in lipoprotein release permease component
sps_RS08100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
sps_RS08110	COG1254	Belongs to the acylphosphatase family
sps_RS08115	COG3150	esterase
sps_RS08120	COG1472	Belongs to the glycosyl hydrolase 3 family
sps_RS08125	COG1760	l-serine dehydratase
sps_RS08145	COG3724	N-succinylarginine dihydrolase activity
sps_RS08155	COG1301	dicarboxylic acid transport
sps_RS08160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
sps_RS08165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
sps_RS08170	COG0563	adenylate kinase activity
sps_RS08175	COG3118	belongs to the thioredoxin family
sps_RS08180	COG0326	Molecular chaperone. Has ATPase activity
sps_RS08185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
sps_RS08190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
sps_RS08195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
sps_RS08200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
sps_RS08205	COG2832	Protein of unknown function (DUF454)
sps_RS08215	COG3220	belongs to the UPF0276 family
sps_RS08225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
sps_RS08235	COG3385	transposase activity
sps_RS08240	COG0616	signal peptide processing
sps_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS08255	COG1187	pseudouridine synthase activity
sps_RS08260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
sps_RS08270	COG0009	L-threonylcarbamoyladenylate synthase
sps_RS08280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
sps_RS08285	COG0512	Glutamine amidotransferase of anthranilate synthase
sps_RS08290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
sps_RS08295	COG0135	phosphoribosylanthranilate isomerase activity
sps_RS08295	COG0134	indole-3-glycerol-phosphate synthase activity
sps_RS08300	COG0133	tryptophan synthase activity
sps_RS08305	COG0159	tryptophan synthase activity
sps_RS08315	COG4946	Tricorn protease homolog
sps_RS08315	COG1506	peptidase
sps_RS08315	COG0823	Involved in the tonB-independent uptake of proteins
sps_RS08325	COG2917	probably involved in intracellular septation
sps_RS08330	COG2350	Protein conserved in bacteria
sps_RS08345	COG4977	sequence-specific DNA binding
sps_RS08350	COG0446	pyridine nucleotide-disulphide oxidoreductase
sps_RS08350	COG1902	pentaerythritol trinitrate reductase activity
sps_RS08360	COG5001	Diguanylate cyclase
sps_RS08360	COG4251	negative regulation of phosphorylation
sps_RS08360	COG3706	GGDEF domain
sps_RS08360	COG2203	Gaf domain
sps_RS08405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
sps_RS08455	COG0823	Involved in the tonB-independent uptake of proteins
sps_RS08465	COG4191	Histidine kinase
sps_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS08475	COG0583	DNA-binding transcription factor activity
sps_RS08480	COG1620	l-lactate permease
sps_RS08535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
sps_RS08560	COG0583	DNA-binding transcription factor activity
sps_RS08585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
sps_RS08590	COG1286	toxin biosynthetic process
sps_RS08595	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
sps_RS08600	COG0285	dihydrofolate synthase activity
sps_RS08605	COG0101	tRNA pseudouridine synthase activity
sps_RS08615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
sps_RS08620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
sps_RS08625	COG2977	Belongs to the P-Pant transferase superfamily
sps_RS08635	COG1917	Cupin 2, conserved barrel domain protein
sps_RS08635	COG4977	sequence-specific DNA binding
sps_RS08640	COG4771	TonB-dependent receptor
sps_RS08650	COG3433	isochorismatase activity
sps_RS08650	COG2226	methyltransferase
sps_RS08650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sps_RS08675	COG1021	2,3-dihydroxybenzoate-AMP ligase
sps_RS08680	COG1132	(ABC) transporter
sps_RS08685	COG1132	(ABC) transporter
sps_RS08690	COG0826	peptidase U32
sps_RS08695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
sps_RS08700	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
sps_RS08700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
sps_RS08705	COG5002	protein histidine kinase activity
sps_RS08740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
sps_RS08745	COG2890	protein-(glutamine-N5) methyltransferase activity
sps_RS08750	COG2840	Smr protein MutS2
sps_RS08755	COG2062	phosphohistidine phosphatase, SixA
sps_RS08760	COG1025	Belongs to the peptidase M16 family
sps_RS08765	COG3300	MHYT domain
sps_RS08765	COG5001	Diguanylate cyclase
sps_RS08780	COG1250	3-hydroxyacyl-CoA dehydrogenase
sps_RS08780	COG1024	Enoyl-CoA hydratase
sps_RS08785	COG0183	Belongs to the thiolase family
sps_RS08790	COG0714	Associated with various cellular activities
sps_RS08820	COG1595	DNA-templated transcription, initiation
sps_RS08835	COG2067	long-chain fatty acid transport protein
sps_RS08855	COG4628	conserved protein (DUF2132)
sps_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS08880	COG3321	synthase
sps_RS08880	COG0604	alcohol dehydrogenase
sps_RS08885	COG0583	DNA-binding transcription factor activity
sps_RS08895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sps_RS08905	COG0602	queuosine metabolic process
sps_RS08920	COG1846	Transcriptional regulator
sps_RS08925	COG2130	NADP-dependent
sps_RS08930	COG1752	Esterase of the alpha-beta hydrolase superfamily
sps_RS08940	COG0513	Belongs to the DEAD box helicase family
sps_RS08950	COG1451	nucleotide metabolic process
sps_RS08965	COG1472	Belongs to the glycosyl hydrolase 3 family
sps_RS08970	COG0739	heme binding
sps_RS08975	COG0419	ATPase involved in DNA repair
sps_RS08985	COG3977	Valine--pyruvate aminotransferase
sps_RS08995	COG0730	response to heat
sps_RS09000	COG0583	DNA-binding transcription factor activity
sps_RS09020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sps_RS09025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
sps_RS09050	COG0848	biopolymer transport protein
sps_RS09055	COG0811	peptide transport
sps_RS09060	COG0811	peptide transport
sps_RS09085	COG0417	DNA replication proofreading
sps_RS09090	COG1199	ATP-dependent helicase activity
sps_RS09095	COG0730	response to heat
sps_RS09105	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
sps_RS09120	COG1555	photosystem II stabilization
sps_RS09120	COG1596	polysaccharide export
sps_RS09125	COG0471	metal ion transport
sps_RS09135	COG3768	UPF0283 membrane protein
sps_RS09140	COG3106	COG3106 Predicted ATPase
sps_RS09155	COG1842	Phage shock protein A
sps_RS09160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
sps_RS09165	COG0747	negative chemotaxis
sps_RS09170	COG4168	peptide transport system, permease
sps_RS09175	COG4171	peptide transport system, permease
sps_RS09185	COG4172	Belongs to the ABC transporter superfamily
sps_RS09190	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
sps_RS09205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
sps_RS09215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
sps_RS09220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
sps_RS09225	COG0740	serine-type endopeptidase activity
sps_RS09230	COG0544	peptidyl-prolyl cis-trans isomerase activity
sps_RS09250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
sps_RS09255	COG0215	cysteine-tRNA ligase activity
sps_RS09260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
sps_RS09265	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
sps_RS09285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
sps_RS09365	COG1573	uracil-dna glycosylase
sps_RS09370	COG3706	GGDEF domain
sps_RS09390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS09425	COG2885	chlorophyll binding
sps_RS09480	COG0583	DNA-binding transcription factor activity
sps_RS09490	COG1929	Belongs to the glycerate kinase type-1 family
sps_RS09495	COG0076	glutamate decarboxylase activity
sps_RS09515	COG1121	(ABC) transporter
sps_RS09520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
sps_RS09525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
sps_RS09535	COG3011	Protein conserved in bacteria
sps_RS09585	COG0612	Peptidase, M16
sps_RS09595	COG1278	Cold shock
sps_RS09635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
sps_RS09650	COG0564	pseudouridine synthase activity
sps_RS09660	COG3328	transposase activity
sps_RS09680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
sps_RS09685	COG0318	PFAM AMP-dependent synthetase and ligase
sps_RS09690	COG0596	Alpha beta hydrolase
sps_RS09695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
sps_RS09725	COG0704	Plays a role in the regulation of phosphate uptake
sps_RS09735	COG0581	inorganic phosphate transmembrane transporter activity
sps_RS09765	COG2067	long-chain fatty acid transport protein
sps_RS09780	COG3710	Transcriptional regulator
sps_RS09790	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
sps_RS09820	COG1957	nucleoside hydrolase
sps_RS09830	COG3341	Caulimovirus viroplasmin
sps_RS09830	COG0328	RNA-DNA hybrid ribonuclease activity
sps_RS09845	COG0583	DNA-binding transcription factor activity
sps_RS09850	COG2910	NAD(P)H-binding
sps_RS09860	COG0596	Alpha beta hydrolase
sps_RS09865	COG0583	DNA-binding transcription factor activity
sps_RS09885	COG3483	tryptophan 2,3-dioxygenase activity
sps_RS09895	COG3436	PFAM IS66 Orf2 family protein
sps_RS09915	COG1073	alpha beta
sps_RS09950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
sps_RS09955	COG0372	Belongs to the citrate synthase family
sps_RS09960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
sps_RS09975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
sps_RS09980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
sps_RS09985	COG0488	(ABC) transporter
sps_RS10010	COG2217	Heavy metal translocating P-type atpase
sps_RS10030	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS10040	COG1024	Enoyl-CoA hydratase
sps_RS10045	COG1024	Enoyl-CoA hydratase
sps_RS10050	COG1960	acyl-CoA dehydrogenase activity
sps_RS10075	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
sps_RS10100	COG3047	cAMP biosynthetic process
sps_RS10120	COG1946	Acyl-CoA thioesterase
sps_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS10130	COG1575	Belongs to the MenA family. Type 1 subfamily
sps_RS10145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
sps_RS10150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
sps_RS10155	COG0826	peptidase U32
sps_RS10170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
sps_RS10190	COG3501	Rhs element vgr protein
sps_RS10200	COG0564	pseudouridine synthase activity
sps_RS10205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
sps_RS10230	COG1960	acyl-CoA dehydrogenase activity
sps_RS10235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
sps_RS10240	COG1024	Enoyl-CoA hydratase
sps_RS10245	COG4770	biotin carboxylase activity
sps_RS10260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
sps_RS10265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
sps_RS10275	COG2165	general secretion pathway protein
sps_RS10280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
sps_RS10290	COG1435	thymidine kinase activity
sps_RS10295	COG1757	Na H antiporter
sps_RS10315	COG0804	urea catabolic process
sps_RS10320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
sps_RS10330	COG1720	tRNA m6t6A37 methyltransferase activity
sps_RS10335	COG0110	maltose O-acetyltransferase activity
sps_RS10345	COG0442	prolyl-tRNA aminoacylation
sps_RS10350	COG0583	DNA-binding transcription factor activity
sps_RS10360	COG4948	Mandelate Racemase Muconate Lactonizing
sps_RS10400	COG0037	tRNA processing
sps_RS10405	COG0587	DNA-directed DNA polymerase activity
sps_RS10410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
sps_RS10415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
sps_RS10420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
sps_RS10425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
sps_RS10430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
sps_RS10445	COG0750	zinc metalloprotease
sps_RS10450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
sps_RS10455	COG0575	Belongs to the CDS family
sps_RS10460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
sps_RS10465	COG0233	cytoplasmic translational termination
sps_RS10470	COG0528	UMP kinase activity
sps_RS10475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
sps_RS10480	COG0052	Belongs to the universal ribosomal protein uS2 family
sps_RS10485	COG0024	Methionine aminopeptidase
sps_RS10490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
sps_RS10495	COG2171	N-acyltransferase activity
sps_RS10515	COG3328	transposase activity
sps_RS10520	COG0788	formyltetrahydrofolate deformylase activity
sps_RS10525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
sps_RS10525	COG1263	PTS System
sps_RS10530	COG0716	FMN binding
sps_RS10540	COG0564	pseudouridine synthase activity
sps_RS10585	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
sps_RS10620	COG2015	COG2015, Alkyl sulfatase and related hydrolases
sps_RS10645	COG1136	(ABC) transporter
sps_RS10645	COG0577	efflux transmembrane transporter activity
sps_RS10680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS10685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS10705	COG3710	Transcriptional regulator
sps_RS10720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
sps_RS10750	COG2070	2-Nitropropane dioxygenase
sps_RS10750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
sps_RS10775	COG2233	PERMEase
sps_RS10800	COG4206	TonB-dependent receptor
sps_RS10805	COG0583	DNA-binding transcription factor activity
sps_RS10810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
sps_RS10815	COG1473	amidohydrolase
sps_RS10845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS10850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS10870	COG0583	DNA-binding transcription factor activity
sps_RS10880	COG0840	transmembrane signaling receptor activity
sps_RS10895	COG3291	Pkd domain containing protein
sps_RS10905	COG5002	protein histidine kinase activity
sps_RS10910	COG0745	RESPONSE REGULATOR receiver
sps_RS10920	COG2974	May be involved in recombination
sps_RS10940	COG1611	Belongs to the LOG family
sps_RS10945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
sps_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS10965	COG2329	Antibiotic biosynthesis monooxygenase
sps_RS10975	COG2095	MarC family integral membrane protein
sps_RS10980	COG1506	peptidase
sps_RS10980	COG4946	Tricorn protease homolog
sps_RS10980	COG0823	Involved in the tonB-independent uptake of proteins
sps_RS10985	COG0473	3-isopropylmalate dehydrogenase activity
sps_RS10990	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
sps_RS10995	COG2363	Small membrane protein
sps_RS11005	COG0583	DNA-binding transcription factor activity
sps_RS11015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
sps_RS11015	COG0301	tRNA thio-modification
sps_RS11025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
sps_RS11030	COG1722	exodeoxyribonuclease VII activity
sps_RS11035	COG0142	geranyltranstransferase activity
sps_RS11040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
sps_RS11045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
sps_RS11050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
sps_RS11060	COG0523	cobalamin synthesis protein
sps_RS11070	COG0659	secondary active sulfate transmembrane transporter activity
sps_RS11110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS11115	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS11120	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS11125	COG1805	sodium ion transport
sps_RS11130	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS11155	COG4232	protein-disulfide reductase activity
sps_RS11175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
sps_RS11225	COG4964	Belongs to the GSP D family
sps_RS11265	COG0625	glutathione transferase activity
sps_RS11270	COG3097	Belongs to the UPF0267 family
sps_RS11275	COG0840	transmembrane signaling receptor activity
sps_RS11295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
sps_RS11295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
sps_RS11315	COG0386	Belongs to the glutathione peroxidase family
sps_RS11320	COG3291	Pkd domain containing protein
sps_RS11335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
sps_RS11340	COG0058	SHG alpha-glucan phosphorylase activity
sps_RS11355	COG1640	4-alpha-glucanotransferase
sps_RS11365	COG0840	transmembrane signaling receptor activity
sps_RS11370	COG1454	alcohol dehydrogenase
sps_RS11385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS11405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
sps_RS11410	COG1607	acyl-coa hydrolase
sps_RS11420	COG1785	Belongs to the alkaline phosphatase family
sps_RS11430	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
sps_RS11435	COG2860	membrane
sps_RS11440	COG0668	transmembrane transport
sps_RS11455	COG0583	DNA-binding transcription factor activity
sps_RS11470	COG0023	Translation Initiation Factor
sps_RS11475	COG1678	Uncharacterized ACR, COG1678
sps_RS11480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
sps_RS11500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
sps_RS11505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
sps_RS11510	COG0762	integral membrane protein
sps_RS11520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
sps_RS11525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
sps_RS11535	COG0583	DNA-binding transcription factor activity
sps_RS11545	COG2066	Belongs to the glutaminase family
sps_RS11550	COG3171	Protein conserved in bacteria
sps_RS11555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
sps_RS11560	COG1194	a g-specific adenine glycosylase
sps_RS11565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
sps_RS11570	COG2353	YceI-like domain
sps_RS11575	COG3038	cytochrome b561
sps_RS11600	COG0738	Major facilitator superfamily
sps_RS11610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
sps_RS11615	COG2971	BadF BadG BcrA BcrD
sps_RS11655	COG1609	Transcriptional regulator
sps_RS11705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
sps_RS11710	COG1047	Peptidyl-prolyl cis-trans
sps_RS11715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
sps_RS11720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
sps_RS11725	COG0196	riboflavin kinase activity
sps_RS11730	COG0728	peptidoglycan biosynthetic process
sps_RS11735	COG0268	Binds directly to 16S ribosomal RNA
sps_RS11740	COG0640	Transcriptional regulator
sps_RS11755	COG3022	response to hydroperoxide
sps_RS11760	COG1115	amino acid carrier protein
sps_RS11765	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
sps_RS11775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
sps_RS11780	COG0166	Belongs to the GPI family
sps_RS11800	COG4191	Histidine kinase
sps_RS11800	COG0784	Response regulator, receiver
sps_RS11805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
sps_RS11815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
sps_RS11820	COG0083	homoserine kinase activity
sps_RS11825	COG0527	aspartate kinase activity
sps_RS11825	COG0460	homoserine dehydrogenase
sps_RS11840	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
sps_RS11855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
sps_RS11860	COG1605	Chorismate mutase
sps_RS11860	COG0077	Prephenate dehydratase
sps_RS11870	COG3328	transposase activity
sps_RS11875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
sps_RS11880	COG1151	hydroxylamine reductase activity
sps_RS11885	COG1605	Chorismate mutase
sps_RS11885	COG0287	Prephenate dehydrogenase
sps_RS11890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
sps_RS11900	COG0335	large ribosomal subunit rRNA binding
sps_RS11905	COG0336	Belongs to the RNA methyltransferase TrmD family
sps_RS11910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
sps_RS11915	COG0228	four-way junction DNA binding
sps_RS11920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
sps_RS11925	COG4137	Cytochrome C assembly protein
sps_RS11930	COG4536	flavin adenine dinucleotide binding
sps_RS11945	COG0736	holo-[acyl-carrier-protein] synthase activity
sps_RS11950	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
sps_RS11965	COG0571	ribonuclease III activity
sps_RS11970	COG0681	Belongs to the peptidase S26 family
sps_RS11975	COG0481	GTPase activity
sps_RS11985	COG3026	antisigma factor binding
sps_RS11995	COG1595	DNA-templated transcription, initiation
sps_RS12000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
sps_RS12010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
sps_RS12015	COG0583	DNA-binding transcription factor activity
sps_RS12025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
sps_RS12030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
sps_RS12035	COG0730	response to heat
sps_RS12040	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
sps_RS12045	COG0494	nUDIX hydrolase
sps_RS12050	COG3066	DNA modification
sps_RS12060	COG0583	DNA-binding transcription factor activity
sps_RS12070	COG2198	Histidine kinase
sps_RS12070	COG5002	protein histidine kinase activity
sps_RS12070	COG0784	Response regulator, receiver
sps_RS12075	COG1242	4 iron, 4 sulfur cluster binding
sps_RS12080	COG0067	glutamate synthase
sps_RS12080	COG0069	glutamate synthase activity
sps_RS12080	COG0070	glutamate synthase
sps_RS12085	COG0493	'glutamate synthase
sps_RS12090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
sps_RS12225	COG4790	Type iii secretion
sps_RS12235	COG3710	Transcriptional regulator
sps_RS12265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
sps_RS12270	COG4789	Type iii secretion
sps_RS12345	COG3104	oligopeptide transport
sps_RS12360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
sps_RS12365	COG0741	lytic transglycosylase activity
sps_RS12365	COG1196	nuclear chromosome segregation
sps_RS12365	COG0739	heme binding
sps_RS12370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
sps_RS12375	COG3710	Transcriptional regulator
sps_RS12385	COG1506	peptidase
sps_RS12390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
sps_RS12405	COG0316	Belongs to the HesB IscA family
sps_RS12415	COG0038	chloride channel
sps_RS12425	COG0861	Integral membrane protein TerC family
sps_RS12460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
sps_RS12480	COG3267	Type II secretory pathway component ExeA
sps_RS12480	COG3409	Peptidoglycan-binding domain 1 protein
sps_RS12485	COG0617	tRNA 3'-terminal CCA addition
sps_RS12495	COG1376	ErfK ybiS ycfS ynhG family protein
sps_RS12495	COG1388	LysM domain
sps_RS12500	COG2226	methyltransferase
sps_RS12505	COG1968	undecaprenyl-diphosphatase activity
sps_RS12515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
sps_RS12520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
sps_RS12525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
sps_RS12530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
sps_RS12535	COG1610	YqeY-like protein
sps_RS12545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
sps_RS12555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
sps_RS12560	COG1177	transmembrane transport
sps_RS12565	COG1176	ABC-type spermidine putrescine transport system, permease component I
sps_RS12570	COG3842	ATPase activity
sps_RS12580	COG0174	glutamine synthetase
sps_RS12595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
sps_RS12605	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS12610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
sps_RS12675	COG5492	domain, Protein
sps_RS12675	COG4932	domain protein
sps_RS12680	COG0545	Peptidyl-prolyl cis-trans isomerase
sps_RS12695	COG0006	proline dipeptidase activity
sps_RS12700	COG1940	carbohydrate kinase activity
sps_RS12700	COG1846	Transcriptional regulator
sps_RS12705	COG2814	Major facilitator Superfamily
sps_RS12710	COG0006	proline dipeptidase activity
sps_RS12715	COG1396	sequence-specific DNA binding
sps_RS12720	COG3135	benzoate transporter
sps_RS12725	COG5001	Diguanylate cyclase
sps_RS12725	COG1716	ATPase activity
sps_RS12730	COG0513	Belongs to the DEAD box helicase family
sps_RS12740	COG2268	Band 7 protein
sps_RS12750	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
sps_RS12770	COG1858	cytochrome C peroxidase
sps_RS12775	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
sps_RS12780	COG3850	Histidine kinase
sps_RS12785	COG2197	response regulator
sps_RS12790	COG3385	transposase activity
sps_RS12795	COG3112	Uncharacterised protein family (UPF0231)
sps_RS12800	COG0545	Peptidyl-prolyl cis-trans isomerase
sps_RS12810	COG2900	Belongs to the SlyX family
sps_RS12815	COG0242	peptide deformylase activity
sps_RS12855	COG1346	cytolysis
sps_RS12865	COG0583	DNA-binding transcription factor activity
sps_RS12870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
sps_RS12875	COG2354	Protein conserved in bacteria
sps_RS12880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
sps_RS12905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
sps_RS12910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
sps_RS12920	COG4974	Belongs to the 'phage' integrase family
sps_RS12930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
sps_RS12935	COG0513	Belongs to the DEAD box helicase family
sps_RS12980	COG0191	fructose-bisphosphate aldolase activity
sps_RS12985	COG0126	phosphoglycerate kinase activity
sps_RS12995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
sps_RS13000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
sps_RS13050	COG1760	l-serine dehydratase
sps_RS13055	COG0814	amino acid
sps_RS13065	COG0456	acetyltransferase
sps_RS13070	COG0667	Aldo Keto reductase
sps_RS13080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
sps_RS13085	COG2166	iron-sulfur cluster assembly
sps_RS13090	COG0436	Aminotransferase
sps_RS13095	COG4221	oxidoreductase activity
sps_RS13100	COG1073	alpha beta
sps_RS13105	COG0583	DNA-binding transcription factor activity
sps_RS13110	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS13125	COG2358	TRAP transporter, solute receptor (TAXI family
sps_RS13140	COG2985	domain, Protein
sps_RS13155	COG1129	ABC transporter
sps_RS13175	COG0826	peptidase U32
sps_RS13185	COG3604	Transcriptional regulator
sps_RS13200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
sps_RS13200	COG1017	nitric oxide dioxygenase activity
sps_RS13225	COG3708	Transcriptional regulator
sps_RS13225	COG2207	Transcriptional regulator
sps_RS13245	COG3610	response to peptide
sps_RS13250	COG2966	Psort location CytoplasmicMembrane, score
sps_RS13255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
sps_RS13260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
sps_RS13265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
sps_RS13270	COG0142	geranyltranstransferase activity
sps_RS13275	COG0039	L-malate dehydrogenase activity
sps_RS13280	COG1438	arginine binding
sps_RS13285	COG1917	Cupin 2, conserved barrel domain protein
sps_RS13295	COG1278	Cold shock
sps_RS13310	COG3328	transposase activity
sps_RS13350	COG1253	flavin adenine dinucleotide binding
sps_RS13385	COG5433	transposase activity
sps_RS13415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
sps_RS13425	COG4191	Histidine kinase
sps_RS13425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS13455	COG3220	belongs to the UPF0276 family
sps_RS13475	COG1294	oxidase, subunit
sps_RS13485	COG0583	DNA-binding transcription factor activity
sps_RS13490	COG1629	transport
sps_RS13490	COG4774	siderophore transport
sps_RS13515	COG0123	including yeast histone deacetylase and acetoin utilization protein
sps_RS13525	COG1609	Transcriptional regulator
sps_RS13530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
sps_RS13535	COG1879	ABC-type sugar transport system periplasmic component
sps_RS13540	COG1172	Belongs to the binding-protein-dependent transport system permease family
sps_RS13545	COG1129	ABC transporter
sps_RS13580	COG1741	Belongs to the pirin family
sps_RS13590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
sps_RS13590	COG3453	Protein conserved in bacteria
sps_RS13625	COG0628	permease
sps_RS13635	COG1566	PFAM secretion protein HlyD family protein
sps_RS13675	COG4251	negative regulation of phosphorylation
sps_RS13675	COG3706	GGDEF domain
sps_RS13675	COG2203	Gaf domain
sps_RS13675	COG5001	Diguanylate cyclase
sps_RS13690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
sps_RS13700	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
sps_RS13715	COG3487	Iron-regulated protein
sps_RS13735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
sps_RS13735	COG1648	precorrin-2 dehydrogenase activity
sps_RS13775	COG0673	inositol 2-dehydrogenase activity
sps_RS13780	COG0175	sulfate reduction
sps_RS13785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
sps_RS13790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
sps_RS13800	COG0705	Rhomboid family
sps_RS13825	COG1560	Kdo2-lipid A biosynthetic process
sps_RS13835	COG0612	Peptidase, M16
sps_RS13840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
sps_RS13845	COG0840	transmembrane signaling receptor activity
sps_RS13880	COG3263	regulation of cellular component size
sps_RS13885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
sps_RS13900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
sps_RS13940	COG1757	Na H antiporter
sps_RS13950	COG1187	pseudouridine synthase activity
sps_RS13960	COG3344	reverse transcriptase
sps_RS13975	COG1418	mRNA catabolic process
sps_RS13995	COG3328	transposase activity
sps_RS14000	COG3591	Belongs to the peptidase S1B family
sps_RS14000	COG4990	cell redox homeostasis
sps_RS14005	COG0814	amino acid
sps_RS14010	COG2119	membrane
sps_RS14025	COG2050	protein possibly involved in aromatic compounds catabolism
sps_RS14040	COG3647	Membrane
sps_RS14045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
sps_RS14050	COG0354	folic acid binding
sps_RS14060	COG5433	transposase activity
sps_RS14090	COG1136	(ABC) transporter
sps_RS14095	COG0577	efflux transmembrane transporter activity
sps_RS14105	COG3300	MHYT domain
sps_RS14105	COG5001	Diguanylate cyclase
sps_RS14110	COG1776	CheC inhibitor of MCP methylation
sps_RS14115	COG2201	protein-glutamate methylesterase activity
sps_RS14125	COG4191	Histidine kinase
sps_RS14130	COG3062	negative regulation of establishment of protein localization
sps_RS14135	COG0243	molybdopterin cofactor binding
sps_RS14140	COG3043	anaerobic respiration
sps_RS14145	COG3385	transposase activity
sps_RS14200	COG1357	PFAM Pentapeptide repeats (8 copies)
sps_RS14210	COG2207	Transcriptional regulator
sps_RS14220	COG5001	Diguanylate cyclase
sps_RS14235	COG0189	ligase activity
sps_RS14235	COG4067	protein conserved in archaea
sps_RS14240	COG0439	Biotin carboxylase
sps_RS14245	COG0583	DNA-binding transcription factor activity
sps_RS14260	COG3091	SprT-like family
sps_RS14270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
sps_RS14275	COG0189	ligase activity
sps_RS14280	COG1785	Belongs to the alkaline phosphatase family
sps_RS14300	COG2813	Specifically methylates the guanine in position
sps_RS14335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS14335	COG4191	Histidine kinase
sps_RS14340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
sps_RS14355	COG0500	methyltransferase
sps_RS14375	COG4232	protein-disulfide reductase activity
sps_RS14380	COG4651	solute:proton antiporter activity
sps_RS14380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
sps_RS14390	COG3250	beta-galactosidase activity
sps_RS14395	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
sps_RS14400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
sps_RS14405	COG2017	converts alpha-aldose to the beta-anomer
sps_RS14415	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS14415	COG3321	synthase
sps_RS14415	COG0604	alcohol dehydrogenase
sps_RS14420	COG3291	Pkd domain containing protein
sps_RS14465	COG2814	Major facilitator Superfamily
sps_RS14470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
sps_RS14505	COG0583	DNA-binding transcription factor activity
sps_RS14520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
sps_RS14540	COG3258	Cytochrome c
sps_RS14555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
sps_RS14560	COG0460	homoserine dehydrogenase
sps_RS14560	COG0527	aspartate kinase activity
sps_RS14565	COG0626	cystathionine gamma-synthase activity
sps_RS14570	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
sps_RS14625	COG0455	bacterial-type flagellum organization
sps_RS14635	COG4964	Belongs to the GSP D family
sps_RS14655	COG0583	DNA-binding transcription factor activity
sps_RS14710	COG1902	pentaerythritol trinitrate reductase activity
sps_RS14720	COG0583	DNA-binding transcription factor activity
sps_RS14730	COG2199	diguanylate cyclase activity
sps_RS14730	COG2203	Gaf domain
sps_RS14735	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
sps_RS14745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
sps_RS14785	COG0564	pseudouridine synthase activity
sps_RS14810	COG2731	YhcH YjgK YiaL family protein
sps_RS14815	COG1104	cysteine desulfurase activity
sps_RS14820	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
sps_RS14935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
sps_RS14940	COG0511	ligase activity, forming carbon-carbon bonds
sps_RS14945	COG0439	Biotin carboxylase
sps_RS14965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
sps_RS14990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
sps_RS15015	COG2226	methyltransferase
sps_RS15025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
sps_RS15030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
sps_RS15035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
sps_RS15040	COG0805	protein transport
sps_RS15055	COG3706	GGDEF domain
sps_RS15055	COG4251	negative regulation of phosphorylation
sps_RS15055	COG5001	Diguanylate cyclase
sps_RS15055	COG2203	Gaf domain
sps_RS15075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS15080	COG1538	Outer membrane efflux protein
sps_RS15110	COG0513	Belongs to the DEAD box helicase family
sps_RS15115	COG3118	belongs to the thioredoxin family
sps_RS15120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
sps_RS15130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
sps_RS15135	COG1053	succinate dehydrogenase
sps_RS15150	COG2264	protein methyltransferase activity
sps_RS15155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
sps_RS15160	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
sps_RS15165	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
sps_RS15170	COG1011	Hydrolase
sps_RS15175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
sps_RS15185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
sps_RS15190	COG0019	diaminopimelate decarboxylase activity
sps_RS15200	COG3072	Adenylate cyclase
sps_RS15205	COG0181	hydroxymethylbilane synthase activity
sps_RS15210	COG1587	Uroporphyrinogen-III synthase
sps_RS15215	COG2959	enzyme of heme biosynthesis
sps_RS15290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS15295	COG1538	Outer membrane efflux protein
sps_RS15345	COG1309	transcriptional regulator
sps_RS15350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS15355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS15370	COG4452	Inner membrane protein CreD
sps_RS15380	COG1522	sequence-specific DNA binding
sps_RS15385	COG0733	neurotransmitter:sodium symporter activity
sps_RS15405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
sps_RS15420	COG0129	dihydroxy-acid dehydratase activity
sps_RS15425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
sps_RS15430	COG3978	acetolactate synthase activity
sps_RS15440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
sps_RS15445	COG0583	DNA-binding transcription factor activity
sps_RS15460	COG1045	serine acetyltransferase
sps_RS15480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
sps_RS15485	COG0210	DNA helicase
sps_RS15505	COG0330	HflC and HflK could
sps_RS15510	COG0330	HflC and HflK could
sps_RS15540	COG0668	transmembrane transport
sps_RS15575	COG2153	protein acetylation
sps_RS15580	COG0641	radical SAM
sps_RS15605	COG3119	arylsulfatase activity
sps_RS15615	COG0583	DNA-binding transcription factor activity
sps_RS15640	COG2358	TRAP transporter, solute receptor (TAXI family
sps_RS15645	COG0217	transcriptional regulatory protein
sps_RS15670	COG0789	Transcriptional regulator
sps_RS15675	COG0138	bifunctional purine biosynthesis protein purh
sps_RS15680	COG0151	Belongs to the GarS family
sps_RS15685	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS15690	COG5002	protein histidine kinase activity
sps_RS15690	COG5001	Diguanylate cyclase
sps_RS15705	COG0745	RESPONSE REGULATOR receiver
sps_RS15710	COG5002	protein histidine kinase activity
sps_RS15715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
sps_RS15730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
sps_RS15745	COG1011	Hydrolase
sps_RS15755	COG0681	Belongs to the peptidase S26 family
sps_RS15785	COG0784	Response regulator, receiver
sps_RS15785	COG0835	chemotaxis
sps_RS15795	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
sps_RS15810	COG3655	Transcriptional regulator
sps_RS15825	COG1757	Na H antiporter
sps_RS15830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
sps_RS15885	COG1979	alcohol dehydrogenase
sps_RS15890	COG1309	transcriptional regulator
sps_RS15900	COG3243	poly(R)-hydroxyalkanoic acid synthase
sps_RS15910	COG0606	chelatase, subunit chli
sps_RS15915	COG0204	Acyl-transferase
sps_RS15920	COG0204	Acyl-transferase
sps_RS15930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
sps_RS15955	COG3074	FtsZ-dependent cytokinesis
sps_RS15965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
sps_RS15970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
sps_RS16025	COG1335	isochorismatase
sps_RS16035	COG1032	radical SAM domain protein
sps_RS16095	COG0653	protein targeting
sps_RS16100	COG0739	heme binding
sps_RS16110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
sps_RS16115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
sps_RS16120	COG0849	cell division
sps_RS16130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
sps_RS16135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
sps_RS16140	COG0772	Belongs to the SEDS family
sps_RS16145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
sps_RS16150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
sps_RS16155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
sps_RS16160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
sps_RS16165	COG0768	penicillin binding
sps_RS16170	COG3116	cell division
sps_RS16175	COG0275	rRNA processing
sps_RS16180	COG2001	Belongs to the MraZ family
sps_RS16190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
sps_RS16200	COG2067	long-chain fatty acid transport protein
sps_RS16205	COG0066	3-isopropylmalate dehydratase activity
sps_RS16210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
sps_RS16215	COG0473	3-isopropylmalate dehydrogenase activity
sps_RS16220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
sps_RS16230	COG0514	ATP-dependent DNA helicase (RecQ)
sps_RS16235	COG2050	protein possibly involved in aromatic compounds catabolism
sps_RS16240	COG2962	Rard protein
sps_RS16245	COG4771	TonB-dependent receptor
sps_RS16260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
sps_RS16260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
sps_RS16265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
sps_RS16270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
sps_RS16275	COG2003	Belongs to the UPF0758 family
sps_RS16280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
sps_RS16285	COG0756	dUTP diphosphatase activity
sps_RS16290	COG1309	transcriptional regulator
sps_RS16300	COG0302	gtp cyclohydrolase
sps_RS16305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
sps_RS16310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
sps_RS16315	COG1561	YicC-like family, N-terminal region
sps_RS16345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
sps_RS16355	COG0194	GDP metabolic process
sps_RS16360	COG1758	RNA polymerase activity
sps_RS16365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
sps_RS16375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
sps_RS16385	COG1022	Amp-dependent synthetase and ligase
sps_RS16400	COG4585	Histidine kinase
sps_RS16405	COG2197	response regulator
sps_RS16410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
sps_RS16430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
sps_RS16435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
sps_RS16450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
sps_RS16460	COG2986	histidine ammonia-lyase
sps_RS16495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
sps_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS16515	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
sps_RS16525	COG0456	acetyltransferase
sps_RS16530	COG1490	D-aminoacyl-tRNA deacylase activity
sps_RS16545	COG1295	ribonuclease BN
sps_RS16560	COG0348	domain, Protein
sps_RS16565	COG1217	gtp-binding protein TYPA
sps_RS16570	COG0174	glutamine synthetase
sps_RS16580	COG1301	dicarboxylic acid transport
sps_RS16590	COG3852	Histidine kinase
sps_RS16595	COG2204	response regulator
sps_RS16600	COG0583	DNA-binding transcription factor activity
sps_RS16660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
sps_RS16665	COG0006	proline dipeptidase activity
sps_RS16670	COG0500	methyltransferase
sps_RS16675	COG5433	transposase activity
sps_RS16725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
sps_RS16750	COG3344	reverse transcriptase
sps_RS16755	COG2732	(Barnase) inhibitor
sps_RS16770	COG3938	Belongs to the proline racemase family
sps_RS16780	COG3938	Belongs to the proline racemase family
sps_RS16785	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS16795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
sps_RS16870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
sps_RS16870	COG2010	Cytochrome c
sps_RS16875	COG2080	2 iron, 2 sulfur cluster binding
sps_RS16885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
sps_RS16890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
sps_RS16900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
sps_RS16905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
sps_RS16905	COG0517	IMP dehydrogenase activity
sps_RS16925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
sps_RS16990	COG4387	Mu-like prophage protein GP36
sps_RS17000	COG4397	Mu-like prophage major head subunit gpT
sps_RS17010	COG4388	Caudovirus prohead serine protease
sps_RS17050	COG2369	cell adhesion
sps_RS17055	COG4383	Mu-like prophage protein gp29
sps_RS17060	COG4373	Mu-like prophage FluMu protein gp28
sps_RS17070	COG0640	Transcriptional regulator
sps_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS17270	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
sps_RS17310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
sps_RS17315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
sps_RS17330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
sps_RS17335	COG3115	cell septum assembly
sps_RS17340	COG1196	nuclear chromosome segregation
sps_RS17365	COG3227	Zinc metalloprotease (Elastase)
sps_RS17370	COG3227	Zinc metalloprotease (Elastase)
sps_RS17375	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
sps_RS17385	COG5006	permease, DMT superfamily
sps_RS17390	COG1522	sequence-specific DNA binding
sps_RS17395	COG0697	spore germination
sps_RS17400	COG2153	protein acetylation
sps_RS17415	COG1944	ATP diphosphatase activity
sps_RS17420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS17430	COG1309	transcriptional regulator
sps_RS17465	COG1714	RDD family
sps_RS17470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
sps_RS17480	COG4109	DRTGG domain
sps_RS17485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
sps_RS17490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
sps_RS17495	COG0649	NAD binding
sps_RS17500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
sps_RS17510	COG1034	ATP synthesis coupled electron transport
sps_RS17515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
sps_RS17520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
sps_RS17530	COG0713	ATP synthesis coupled electron transport
sps_RS17540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
sps_RS17545	COG1007	ATP synthesis coupled electron transport
sps_RS17550	COG2813	Specifically methylates the guanine in position
sps_RS17560	COG4206	TonB-dependent receptor
sps_RS17565	COG1288	antiporter activity
sps_RS17570	COG2116	formate transmembrane transporter activity
sps_RS17575	COG1882	Formate acetyltransferase
sps_RS17580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
sps_RS17585	COG3092	negative regulation of chromosome organization
sps_RS17590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
sps_RS17595	COG0280	phosphate acetyltransferase
sps_RS17595	COG0857	belongs to the CobB CobQ family
sps_RS17610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
sps_RS17615	COG0628	permease
sps_RS17620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
sps_RS17625	COG1090	epimerase
sps_RS17635	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
sps_RS17640	COG4181	ATPase activity
sps_RS17680	COG0105	UTP biosynthetic process
sps_RS17685	COG2975	iron-sulfur cluster assembly
sps_RS17690	COG0633	Ferredoxin
sps_RS17695	COG0443	Heat shock 70 kDa protein
sps_RS17700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
sps_RS17710	COG0822	iron-sulfur transferase activity
sps_RS17715	COG1104	cysteine desulfurase activity
sps_RS17720	COG1959	2 iron, 2 sulfur cluster binding
sps_RS17760	COG4681	YaeQ
sps_RS17765	COG1648	precorrin-2 dehydrogenase activity
sps_RS17765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
sps_RS17775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
sps_RS17780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
sps_RS17785	COG1862	Preprotein translocase
sps_RS17790	COG0343	queuine tRNA-ribosyltransferase activity
sps_RS17795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
sps_RS17805	COG0564	pseudouridine synthase activity
sps_RS17820	COG0438	transferase activity, transferring glycosyl groups
sps_RS17840	COG0438	transferase activity, transferring glycosyl groups
sps_RS17880	COG0438	transferase activity, transferring glycosyl groups
sps_RS17890	COG0438	transferase activity, transferring glycosyl groups
sps_RS17900	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
sps_RS17905	COG0784	Response regulator, receiver
sps_RS17905	COG0835	chemotaxis
sps_RS17910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
sps_RS17920	COG0513	Belongs to the DEAD box helicase family
sps_RS17925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
sps_RS17935	COG1132	(ABC) transporter
sps_RS17980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
sps_RS18010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
sps_RS18015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
sps_RS18020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
sps_RS18035	COG2814	Major facilitator Superfamily
sps_RS18040	COG0583	DNA-binding transcription factor activity
sps_RS18050	COG0625	glutathione transferase activity
sps_RS18065	COG2154	pterin-4-alpha-carbinolamine dehydratase
sps_RS18075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
sps_RS18080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
sps_RS18085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
sps_RS18085	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
sps_RS18100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
sps_RS18105	COG1940	carbohydrate kinase activity
sps_RS18120	COG1609	Transcriptional regulator
sps_RS18135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
sps_RS18140	COG2204	response regulator
sps_RS18165	COG1366	Belongs to the anti-sigma-factor antagonist family
sps_RS18215	COG0529	Catalyzes the synthesis of activated sulfate
sps_RS18220	COG3273	potassium ion transport
sps_RS18220	COG0471	metal ion transport
sps_RS18225	COG2895	sulfate adenylyltransferase (ATP) activity
sps_RS18235	COG0175	sulfate reduction
sps_RS18245	COG1331	Highly conserved protein containing a thioredoxin domain
sps_RS18290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
sps_RS18305	COG0438	transferase activity, transferring glycosyl groups
sps_RS18320	COG1215	transferase activity, transferring glycosyl groups
sps_RS18340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
sps_RS18385	COG1088	dTDP-glucose 4,6-dehydratase activity
sps_RS18390	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS18395	COG1083	cytidylyl-transferase
sps_RS18400	COG0673	inositol 2-dehydrogenase activity
sps_RS18405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
sps_RS18415	COG2089	acid synthase
sps_RS18425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
sps_RS18425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
sps_RS18435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
sps_RS18465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
sps_RS18470	COG3104	oligopeptide transport
sps_RS18475	COG0745	RESPONSE REGULATOR receiver
sps_RS18500	COG0835	chemotaxis
sps_RS18510	COG1192	Involved in chromosome partitioning
sps_RS18525	COG0784	Response regulator, receiver
sps_RS18525	COG0643	Histidine kinase
sps_RS18525	COG2198	Histidine kinase
sps_RS18530	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
sps_RS18625	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
sps_RS18635	COG1677	Flagellar hook-basal body complex protein FliE
sps_RS18655	COG1516	flagellar protein fliS
sps_RS18665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
sps_RS18685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
sps_RS18690	COG1256	bacterial-type flagellum assembly
sps_RS18690	COG4786	Flagellar basal body rod
sps_RS18695	COG1705	Flagellar rod assembly protein muramidase FlgJ
sps_RS18695	COG3951	Flagellar rod assembly protein muramidase FlgJ
sps_RS18700	COG1706	bacterial-type flagellum-dependent cell motility
sps_RS18715	COG4787	bacterial-type flagellum-dependent cell motility
sps_RS18720	COG1749	Flagellar hook protein flgE
sps_RS18725	COG1749	Flagellar hook protein flgE
sps_RS18730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
sps_RS18740	COG1815	bacterial-type flagellum-dependent cell motility
sps_RS18745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
sps_RS18750	COG0835	chemotaxis
sps_RS18750	COG0784	Response regulator, receiver
sps_RS18830	COG4890	Cyd operon protein YbgT
sps_RS18835	COG1294	oxidase, subunit
sps_RS18850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
sps_RS18860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
sps_RS18860	COG0519	Catalyzes the synthesis of GMP from XMP
sps_RS18865	COG0516	GMP reductase activity
sps_RS18865	COG0517	IMP dehydrogenase activity
sps_RS18870	COG1570	exodeoxyribonuclease VII activity
sps_RS18885	COG1160	GTP binding
sps_RS18890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
sps_RS18895	COG2976	Protein conserved in bacteria
sps_RS18900	COG0124	histidyl-tRNA synthetase
sps_RS18905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
sps_RS18920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
sps_RS18925	COG1253	flavin adenine dinucleotide binding
sps_RS18930	COG0737	Belongs to the 5'-nucleotidase family
sps_RS18935	COG1247	-acetyltransferase
sps_RS18945	COG3530	Putative quorum-sensing-regulated virulence factor
sps_RS18960	COG3228	Belongs to the MtfA family
sps_RS18985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
sps_RS19010	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
sps_RS19015	COG2914	Belongs to the UPF0125 (RnfH) family
sps_RS19020	COG2867	negative regulation of translational initiation
sps_RS19025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
sps_RS19090	COG3501	Rhs element vgr protein
sps_RS19130	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
sps_RS19135	COG0540	Belongs to the ATCase OTCase family
sps_RS19150	COG1764	response to oxidative stress
sps_RS19230	COG1629	transport
sps_RS19230	COG4774	siderophore transport
sps_RS19240	COG5433	transposase activity
sps_RS19255	COG1960	acyl-CoA dehydrogenase activity
sps_RS19275	COG1733	regulation of RNA biosynthetic process
sps_RS19280	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS19290	COG1162	GTPase activity
sps_RS19335	COG0589	response to stress
sps_RS19340	COG0786	glutamate:sodium symporter activity
sps_RS19360	COG1301	dicarboxylic acid transport
sps_RS19370	COG1301	dicarboxylic acid transport
sps_RS19375	COG1671	Belongs to the UPF0178 family
sps_RS19385	COG3710	Transcriptional regulator
sps_RS19390	COG0784	Response regulator, receiver
sps_RS19390	COG5002	protein histidine kinase activity
sps_RS19390	COG2198	Histidine kinase
sps_RS19440	COG2957	Belongs to the agmatine deiminase family
sps_RS19450	COG1757	Na H antiporter
sps_RS19460	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS19470	COG2197	response regulator
sps_RS19500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
sps_RS19505	COG2186	Transcriptional regulator
sps_RS19510	COG3385	transposase activity
sps_RS19630	COG0745	RESPONSE REGULATOR receiver
sps_RS19645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
sps_RS19675	COG0583	DNA-binding transcription factor activity
sps_RS19685	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS19695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
sps_RS19725	COG3710	Transcriptional regulator
sps_RS19730	COG2200	EAL domain
sps_RS19780	COG0745	RESPONSE REGULATOR receiver
sps_RS19790	COG3436	PFAM IS66 Orf2 family protein
sps_RS19800	COG3328	transposase activity
sps_RS19820	COG3328	transposase activity
sps_RS19835	COG3119	arylsulfatase activity
sps_RS19845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
sps_RS19845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
sps_RS19860	COG3119	arylsulfatase activity
sps_RS19890	COG2824	Alkylphosphonate utilization operon protein PhnA
sps_RS19915	COG2197	response regulator
sps_RS19920	COG2249	NAD(P)H dehydrogenase (quinone) activity
sps_RS19930	COG0583	DNA-binding transcription factor activity
sps_RS19935	COG1902	pentaerythritol trinitrate reductase activity
sps_RS19940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS19975	COG0628	permease
sps_RS20005	COG1566	PFAM secretion protein HlyD family protein
sps_RS20010	COG4946	Tricorn protease homolog
sps_RS20010	COG0793	Belongs to the peptidase S41A family
sps_RS20025	COG2304	oxidoreductase activity
sps_RS20035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
sps_RS20040	COG0657	acetylesterase activity
sps_RS20045	COG4667	esterase of the alpha-beta hydrolase superfamily
sps_RS20060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
sps_RS20075	COG2918	glutathione biosynthetic process
sps_RS20080	COG0612	Peptidase, M16
sps_RS20085	COG1238	metal cluster binding
sps_RS20090	COG1301	dicarboxylic acid transport
sps_RS20100	COG0653	protein targeting
sps_RS20115	COG2205	protein histidine kinase activity
sps_RS20115	COG0784	Response regulator, receiver
sps_RS20135	COG3630	sodium ion export across plasma membrane
sps_RS20185	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
sps_RS20190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
sps_RS20195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
sps_RS20205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
sps_RS20210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
sps_RS20220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
sps_RS20225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
sps_RS20230	COG0585	pseudouridine synthase activity
sps_RS20235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
sps_RS20240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
sps_RS20245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
sps_RS20250	COG0148	phosphopyruvate hydratase activity
sps_RS20255	COG0504	CTP synthase activity
sps_RS20260	COG3956	TIGRFAM MazG family protein
sps_RS20265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
sps_RS20270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
sps_RS20295	COG0497	DNA recombination
sps_RS20310	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
sps_RS20315	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
sps_RS20320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
sps_RS20325	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
sps_RS20340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
sps_RS20340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
sps_RS20345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
sps_RS20350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
sps_RS20360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
sps_RS20370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
sps_RS20385	COG0488	(ABC) transporter
sps_RS20410	COG2315	Protein conserved in bacteria
sps_RS20415	COG3064	Membrane
sps_RS20420	COG1187	pseudouridine synthase activity
sps_RS20430	COG3048	D-serine ammonia-lyase activity
sps_RS20440	COG0813	purine-nucleoside phosphorylase activity
sps_RS20460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS20465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS20470	COG2814	Major facilitator Superfamily
sps_RS20485	COG0745	RESPONSE REGULATOR receiver
sps_RS20490	COG2205	protein histidine kinase activity
sps_RS20510	COG0745	RESPONSE REGULATOR receiver
sps_RS20535	COG3713	MltA-interacting MipA family protein
sps_RS20540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
sps_RS20555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
sps_RS20575	COG5433	transposase activity
sps_RS20585	COG0513	Belongs to the DEAD box helicase family
sps_RS20605	COG5001	Diguanylate cyclase
sps_RS20615	COG0826	peptidase U32
sps_RS20620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
sps_RS20665	COG3154	lipid carrier protein
sps_RS20670	COG0826	peptidase U32
sps_RS20675	COG0826	peptidase U32
sps_RS20685	COG0840	transmembrane signaling receptor activity
sps_RS20710	COG3314	Sporulation integral membrane protein YlbJ
sps_RS20715	COG0745	RESPONSE REGULATOR receiver
sps_RS20715	COG3292	Two component regulator propeller
sps_RS20715	COG2205	protein histidine kinase activity
sps_RS20725	COG0517	IMP dehydrogenase activity
sps_RS20730	COG2252	PERMEase
sps_RS20740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
sps_RS20760	COG3381	protein complex oligomerization
sps_RS20765	COG0167	dihydroorotate dehydrogenase activity
sps_RS20775	COG0513	Belongs to the DEAD box helicase family
sps_RS20795	COG0745	RESPONSE REGULATOR receiver
sps_RS20820	COG0784	Response regulator, receiver
sps_RS20820	COG2205	protein histidine kinase activity
sps_RS20820	COG5002	protein histidine kinase activity
sps_RS20830	COG1335	isochorismatase
sps_RS20840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
sps_RS20855	COG0560	Phosphoserine phosphatase
sps_RS20865	COG0813	purine-nucleoside phosphorylase activity
sps_RS20870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
sps_RS20875	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
sps_RS20880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
sps_RS20885	COG3248	Nucleoside-binding outer membrane protein
sps_RS20890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
sps_RS20900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
sps_RS20915	COG1185	polyribonucleotide nucleotidyltransferase activity
sps_RS20925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
sps_RS20930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
sps_RS20935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
sps_RS20940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
sps_RS20945	COG0195	Participates in both transcription termination and antitermination
sps_RS20950	COG0779	Required for maturation of 30S ribosomal subunits
sps_RS20965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
sps_RS20970	COG0149	triose-phosphate isomerase activity
sps_RS20975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
sps_RS20980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
sps_RS20990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
sps_RS20995	COG1534	Rna-binding protein
sps_RS21000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
sps_RS21005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
sps_RS21025	COG0840	transmembrane signaling receptor activity
sps_RS21030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
sps_RS21035	COG0505	Belongs to the CarA family
sps_RS21040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
sps_RS21045	COG0545	Peptidyl-prolyl cis-trans isomerase
sps_RS21055	COG0484	heat shock protein binding
sps_RS21060	COG0443	Heat shock 70 kDa protein
sps_RS21110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
sps_RS21115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
sps_RS21120	COG2252	PERMEase
sps_RS21125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
sps_RS21130	COG2195	Cleaves the N-terminal amino acid of tripeptides
sps_RS21135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
sps_RS21150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
sps_RS21160	COG0583	DNA-binding transcription factor activity
sps_RS21175	COG2193	ferroxidase activity
sps_RS21185	COG2199	diguanylate cyclase activity
sps_RS21190	COG2991	Protein conserved in bacteria
sps_RS21195	COG1477	protein flavinylation
sps_RS21200	COG2871	sodium ion transport
sps_RS21205	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS21210	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS21215	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS21220	COG1805	sodium ion transport
sps_RS21225	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
sps_RS21230	COG1854	S-ribosylhomocysteine lyase activity
sps_RS21235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
sps_RS21250	COG0271	Belongs to the BolA IbaG family
sps_RS21260	COG2813	Specifically methylates the guanine in position
sps_RS21265	COG3344	reverse transcriptase
sps_RS21320	COG2211	Major facilitator Superfamily
sps_RS21325	COG1666	GTP binding
sps_RS21335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
sps_RS21340	COG0733	neurotransmitter:sodium symporter activity
sps_RS21345	COG0583	DNA-binding transcription factor activity
sps_RS21365	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
sps_RS21375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
sps_RS21390	COG3094	Invasion gene expression up-regulator, SirB
sps_RS21405	COG2890	protein-(glutamine-N5) methyltransferase activity
sps_RS21410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
sps_RS21415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
sps_RS21420	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
sps_RS21425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
sps_RS21430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
sps_RS21490	COG0012	GTP binding
sps_RS21495	COG0193	aminoacyl-tRNA hydrolase activity
sps_RS21500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
sps_RS21510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
sps_RS21515	COG1702	phosphate starvation-inducible protein PhoH
sps_RS21520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
sps_RS21525	COG4535	Mg2 and Co2 transporter CorC
sps_RS21530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
sps_RS21545	COG0495	leucyl-tRNA aminoacylation
sps_RS21550	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
sps_RS21560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
sps_RS21565	COG0799	negative regulation of ribosome biogenesis
sps_RS21570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
sps_RS21575	COG0768	penicillin binding
sps_RS21580	COG0772	Belongs to the SEDS family
sps_RS21585	COG2951	lytic endotransglycosylase activity
sps_RS21590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
sps_RS21595	COG1686	Belongs to the peptidase S11 family
sps_RS21600	COG2921	Belongs to the UPF0250 family
sps_RS21605	COG0321	lipoyl(octanoyl) transferase activity
sps_RS21610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
sps_RS21625	COG0783	Belongs to the Dps family
sps_RS21655	COG1183	phosphatidylcholine synthase activity
sps_RS21670	COG0542	response to heat
sps_RS21680	COG0564	pseudouridine synthase activity
sps_RS21685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
sps_RS21700	COG2423	ornithine cyclodeaminase activity
sps_RS21720	COG1187	pseudouridine synthase activity
sps_RS21725	COG3590	peptidase
sps_RS21750	COG0625	glutathione transferase activity
sps_RS21755	COG4206	TonB-dependent receptor
sps_RS21760	COG4565	transcriptional regulatory protein
sps_RS21765	COG3290	protein histidine kinase activity
sps_RS21805	COG0281	malic enzyme
sps_RS21850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
sps_RS21865	COG3436	PFAM IS66 Orf2 family protein
sps_RS21875	COG0840	transmembrane signaling receptor activity
sps_RS21885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
sps_RS21890	COG3360	Dodecin
sps_RS21895	COG2015	COG2015, Alkyl sulfatase and related hydrolases
sps_RS21905	COG4771	TonB-dependent receptor
sps_RS21920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
sps_RS21920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
sps_RS21940	COG2205	protein histidine kinase activity
sps_RS21955	COG1278	Cold shock
sps_RS21965	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS21975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
sps_RS21980	COG2197	response regulator
sps_RS21985	COG2124	cytochrome p450
sps_RS22005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
sps_RS22025	COG4232	protein-disulfide reductase activity
sps_RS22045	COG0069	glutamate synthase activity
sps_RS22050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
sps_RS22070	COG4206	TonB-dependent receptor
sps_RS22075	COG3682	Transcriptional regulator
sps_RS22085	COG3152	Membrane
sps_RS22130	COG5001	Diguanylate cyclase
sps_RS22130	COG3447	MASE1 domain protein
sps_RS22130	COG5002	protein histidine kinase activity
sps_RS22140	COG1070	Carbohydrate kinase
sps_RS22160	COG2814	Major facilitator Superfamily
sps_RS22165	COG0583	DNA-binding transcription factor activity
sps_RS22255	COG5433	transposase activity
sps_RS22300	COG3119	arylsulfatase activity
sps_RS22305	COG0418	dihydroorotase activity
sps_RS22315	COG3706	GGDEF domain
sps_RS22315	COG4251	negative regulation of phosphorylation
sps_RS22315	COG5001	Diguanylate cyclase
sps_RS22315	COG2203	Gaf domain
sps_RS22335	COG1595	DNA-templated transcription, initiation
sps_RS22340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
sps_RS22370	COG2267	carboxylic ester hydrolase activity
sps_RS22380	COG1966	Carbon starvation protein
sps_RS22385	COG4783	chaperone-mediated protein folding
sps_RS22400	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
sps_RS22410	COG0625	glutathione transferase activity
sps_RS22415	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
sps_RS22425	COG4628	conserved protein (DUF2132)
sps_RS22430	COG1280	lysine exporter protein (LysE YggA)
sps_RS22435	COG5433	transposase activity
sps_RS22460	COG0625	glutathione transferase activity
sps_RS22475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
sps_RS22490	COG2837	iron assimilation
sps_RS22495	COG3842	ATPase activity
sps_RS22505	COG1840	ABC-type Fe3 transport system, periplasmic component
sps_RS22540	COG5265	(ABC) transporter
sps_RS22545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
sps_RS22570	COG0004	ammonium transporteR
sps_RS22575	COG0347	Belongs to the P(II) protein family
sps_RS22580	COG0795	lipopolysaccharide-transporting ATPase activity
sps_RS22585	COG0795	lipopolysaccharide-transporting ATPase activity
sps_RS22590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
sps_RS22600	COG0583	DNA-binding transcription factor activity
sps_RS22605	COG1280	lysine exporter protein (LysE YggA)
sps_RS22645	COG2927	DNA polymerase III (CHI subunit)
sps_RS22650	COG0525	valine-tRNA ligase activity
sps_RS22660	COG1355	regulation of microtubule-based process
sps_RS22670	COG5001	Diguanylate cyclase
sps_RS22670	COG3300	MHYT domain
sps_RS22675	COG0840	transmembrane signaling receptor activity
sps_RS22690	COG1584	GPR1 FUN34 yaaH family protein
sps_RS22705	COG0431	NADPH-dependent FMN reductase
sps_RS22735	COG0784	Response regulator, receiver
sps_RS22735	COG2205	protein histidine kinase activity
sps_RS22755	COG0022	dehydrogenase e1 component
sps_RS22760	COG1960	acyl-CoA dehydrogenase activity
sps_RS22765	COG0583	DNA-binding transcription factor activity
sps_RS22780	COG0745	RESPONSE REGULATOR receiver
sps_RS22785	COG5002	protein histidine kinase activity
sps_RS22785	COG3850	Histidine kinase
sps_RS22790	COG3313	Fe-S protein
sps_RS22815	COG1566	PFAM secretion protein HlyD family protein
sps_RS22825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
sps_RS22835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
sps_RS22840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
sps_RS22860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
sps_RS22865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
sps_RS22870	COG2967	ApaG domain
sps_RS22875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
sps_RS22905	COG3436	PFAM IS66 Orf2 family protein
sps_RS22915	COG1192	Involved in chromosome partitioning
sps_RS22930	COG5433	transposase activity
sps_RS22950	COG4644	lycopene metabolic process
sps_RS22985	COG2826	transposase and inactivated derivatives, IS30 family
sps_RS23015	COG4962	Type ii secretion system protein e
sps_RS23035	COG5268	conjugation
sps_RS23045	COG3451	type IV secretory pathway VirB4
sps_RS23055	COG3436	PFAM IS66 Orf2 family protein
sps_RS23110	COG3077	Addiction module antitoxin, RelB DinJ family
sps_RS23115	COG2026	Addiction module toxin, RelE StbE family
sps_RS23225	COG1475	DNA binding
sps_RS23290	COG2826	transposase and inactivated derivatives, IS30 family
sps_RS23310	COG4106	trans-aconitate 2-methyltransferase activity
sps_RS23355	COG3436	PFAM IS66 Orf2 family protein
sps_RS23375	COG3328	transposase activity
sps_RS23410	COG3621	Patatin-like phospholipase
sps_RS23415	COG1902	pentaerythritol trinitrate reductase activity
sps_RS23445	COG1309	transcriptional regulator
sps_RS23470	COG4191	Histidine kinase
sps_RS23480	COG1136	(ABC) transporter
sps_RS23480	COG0577	efflux transmembrane transporter activity
sps_RS23485	COG1136	(ABC) transporter
sps_RS23485	COG0577	efflux transmembrane transporter activity
sps_RS23490	COG1136	(ABC) transporter
sps_RS23510	COG3397	chitin binding
sps_RS23515	COG3038	cytochrome b561
sps_RS23525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
sps_RS23535	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
sps_RS23540	COG1492	cobalamin metabolic process
sps_RS23550	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
sps_RS23555	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
sps_RS23560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sps_RS23565	COG1120	ATPase activity
sps_RS23575	COG4191	Histidine kinase
sps_RS23575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS23590	COG0583	DNA-binding transcription factor activity
sps_RS23595	COG1028	Short-chain dehydrogenase reductase Sdr
sps_RS23600	COG2814	Major facilitator Superfamily
sps_RS23620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
sps_RS23625	COG2423	ornithine cyclodeaminase activity
sps_RS23640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
sps_RS23645	COG0785	Cytochrome C biogenesis protein
sps_RS23670	COG0583	DNA-binding transcription factor activity
sps_RS23680	COG5001	Diguanylate cyclase
sps_RS23680	COG2203	Gaf domain
sps_RS23680	COG3706	GGDEF domain
sps_RS23680	COG4251	negative regulation of phosphorylation
sps_RS23695	COG1484	DNA-dependent DNA replication
sps_RS23700	COG4584	PFAM Integrase catalytic
sps_RS23705	COG3710	Transcriptional regulator
sps_RS23745	COG1459	type II secretion system
sps_RS23750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
sps_RS23755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
sps_RS23775	COG4796	Type ii and iii secretion system protein
sps_RS23790	COG2165	general secretion pathway protein
sps_RS23820	COG0583	DNA-binding transcription factor activity
sps_RS23830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
sps_RS23830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
sps_RS23835	COG0509	glycine decarboxylation via glycine cleavage system
sps_RS23840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
sps_RS23845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
sps_RS23850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
sps_RS23855	COG3079	Belongs to the UPF0149 family
sps_RS23860	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
sps_RS23870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
sps_RS23880	COG3015	lipoprotein NlpE involved in copper resistance
sps_RS23885	COG3291	Pkd domain containing protein
sps_RS23890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
sps_RS23895	COG2165	general secretion pathway protein
sps_RS23930	COG0348	domain, Protein
sps_RS23965	COG1914	H( )-stimulated, divalent metal cation uptake system
sps_RS24035	COG3344	reverse transcriptase
sps_RS24050	COG1132	(ABC) transporter
sps_RS24055	COG0748	coenzyme F420 binding
sps_RS24060	COG3721	Heme iron utilization protein
sps_RS24070	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
sps_RS24075	COG0811	peptide transport
sps_RS24080	COG0848	biopolymer transport protein
sps_RS24085	COG4558	Periplasmic binding protein
sps_RS24090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sps_RS24095	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
sps_RS24115	COG0778	Nitroreductase
sps_RS24125	COG4774	siderophore transport
sps_RS24130	COG0363	glucosamine-6-phosphate deaminase activity
sps_RS24135	COG1187	pseudouridine synthase activity
sps_RS24140	COG0004	ammonium transporteR
sps_RS24155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
sps_RS24175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
sps_RS24180	COG1846	Transcriptional regulator
sps_RS24215	COG2203	Gaf domain
sps_RS24215	COG4251	negative regulation of phosphorylation
sps_RS24215	COG3706	GGDEF domain
sps_RS24215	COG5001	Diguanylate cyclase
sps_RS24220	COG3634	alkyl hydroperoxide reductase activity
sps_RS24240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
sps_RS24270	COG0564	pseudouridine synthase activity
sps_RS24275	COG1522	sequence-specific DNA binding
sps_RS24280	COG1404	Belongs to the peptidase S8 family
sps_RS24290	COG0527	aspartate kinase activity
sps_RS24300	COG0745	RESPONSE REGULATOR receiver
sps_RS24310	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
sps_RS24315	COG1053	succinate dehydrogenase
sps_RS24320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sps_RS24320	COG4191	Histidine kinase
sps_RS24325	COG2204	response regulator
sps_RS24335	COG1301	dicarboxylic acid transport
sps_RS24365	COG1115	amino acid carrier protein
sps_RS24375	COG4772	TonB-dependent receptor
sps_RS24380	COG1730	sister chromatid segregation
sps_RS24405	COG3501	Rhs element vgr protein
sps_RS24430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
sps_RS24435	COG1643	Atp-dependent helicase
sps_RS24460	COG3710	Transcriptional regulator
sps_RS24460	COG0457	Tetratricopeptide repeat
sps_RS24470	COG1489	DNA binding
sps_RS24480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
sps_RS24490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
sps_RS24495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
sps_RS24500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
sps_RS24520	COG0842	Transport permease protein
sps_RS24525	COG1131	(ABC) transporter
sps_RS24535	COG0163	prenyltransferase activity
sps_RS24540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
sps_RS24545	COG0390	transport system, permease component
sps_RS24560	COG1335	isochorismatase
sps_RS24570	COG0583	DNA-binding transcription factor activity
sps_RS24665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
sps_RS24680	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
sps_RS24705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
sps_RS24710	COG3025	triphosphatase activity
sps_RS24715	COG1392	Phosphate transport regulator
sps_RS24720	COG0306	phosphate transporter
sps_RS24725	COG4991	sh3 domain protein
sps_RS24730	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
sps_RS24730	COG0506	proline dehydrogenase activity
sps_RS24730	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
sps_RS24740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
sps_RS24745	COG4988	ABC transporter
sps_RS24770	COG0513	Belongs to the DEAD box helicase family
sps_RS24800	COG0513	Belongs to the DEAD box helicase family
sps_RS24810	COG4191	Histidine kinase
sps_RS24835	COG0840	transmembrane signaling receptor activity
sps_RS24870	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
sps_RS24875	COG0488	(ABC) transporter
sps_RS24885	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
sps_RS24895	COG0429	hydrolase of the alpha beta-hydrolase fold
sps_RS24905	COG3954	Phosphoribulokinase
sps_RS24940	COG1012	belongs to the aldehyde dehydrogenase family
sps_RS24950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
sps_RS24970	COG2969	positive regulation of protein catabolic process
sps_RS24975	COG0625	glutathione transferase activity
sps_RS24980	COG2857	Cytochrome c1
sps_RS24985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
sps_RS24990	COG0723	plastoquinol--plastocyanin reductase activity
sps_RS24995	COG0330	HflC and HflK could
sps_RS25000	COG0330	HflC and HflK could
sps_RS25005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
sps_RS25010	COG1923	regulation of RNA biosynthetic process
sps_RS25015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
sps_RS25020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
sps_RS25030	COG0802	atpase or kinase
sps_RS25035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
sps_RS25035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
sps_RS25060	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
sps_RS25065	COG1162	GTPase activity
sps_RS25070	COG0688	phosphatidylethanolamine metabolic process
sps_RS25075	COG0697	spore germination
sps_RS25080	COG1511	domain protein
sps_RS25080	COG3264	Mechanosensitive ion channel
sps_RS25085	COG0584	glycerophosphoryl diester phosphodiesterase
sps_RS25100	COG0840	transmembrane signaling receptor activity
sps_RS25125	COG3150	esterase
sps_RS25130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
sps_RS25135	COG3151	Protein conserved in bacteria
sps_RS25140	COG0494	nUDIX hydrolase
sps_RS25145	COG1538	Outer membrane efflux protein
sps_RS25165	COG1024	Enoyl-CoA hydratase
sps_RS25185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
sps_RS25230	COG3941	tape measure
sps_RS25260	COG0740	serine-type endopeptidase activity
sps_RS25280	COG4220	transposase activity
sps_RS25295	COG3772	lysozyme
sps_RS25455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
sps_RS25465	COG3591	Belongs to the peptidase S1B family
sps_RS25465	COG4990	cell redox homeostasis
sps_RS25470	COG0359	binds to the 23S rRNA
sps_RS25475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
sps_RS25480	COG2965	DNA replication, synthesis of RNA primer
sps_RS25485	COG0360	Binds together with S18 to 16S ribosomal RNA
sps_RS25505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
sps_RS25510	COG0557	exoribonuclease II activity
sps_RS25515	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
sps_RS25520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
sps_RS25525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
sps_RS25530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
sps_RS25535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
sps_RS25540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
sps_RS25550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
sps_RS25555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
sps_RS25560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
sps_RS25565	COG5007	Belongs to the BolA IbaG family
sps_RS25570	COG3113	response to antibiotic
sps_RS25575	COG2854	intermembrane phospholipid transfer
sps_RS25580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
sps_RS25585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
sps_RS25590	COG1127	ABC transporter
sps_RS25600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
sps_RS25600	COG0517	IMP dehydrogenase activity
sps_RS25605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
sps_RS25620	COG1137	ATPase activity
sps_RS25625	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
sps_RS25635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
sps_RS25645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
sps_RS25650	COG2239	Acts as a magnesium transporter
sps_RS25655	COG2885	chlorophyll binding
sps_RS25660	COG0745	RESPONSE REGULATOR receiver
sps_RS25665	COG5002	protein histidine kinase activity
sps_RS25675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
sps_RS25675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
sps_RS25695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
sps_RS25715	COG2015	COG2015, Alkyl sulfatase and related hydrolases
sps_RS25725	COG0477	Major facilitator Superfamily
sps_RS25735	COG3682	Transcriptional regulator
sps_RS25765	COG1846	Transcriptional regulator
sps_RS25775	COG3123	guanosine phosphorylase activity
sps_RS25795	COG0702	epimerase
sps_RS25820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
sps_RS25835	COG3616	Alanine racemase, N-terminal domain
sps_RS25865	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
sps_RS25920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
sps_RS25925	COG0459	protein refolding
sps_RS25930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
sps_RS25935	COG0534	Mate efflux family protein
sps_RS25940	COG1357	PFAM Pentapeptide repeats (8 copies)
sps_RS25950	COG0583	DNA-binding transcription factor activity
sps_RS25960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
sps_RS25990	COG3850	Histidine kinase
sps_RS25990	COG4999	Histidine kinase
sps_RS25990	COG3437	response regulator, receiver
sps_RS25990	COG2205	protein histidine kinase activity
sps_RS25995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
sps_RS26000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
sps_RS26010	COG1024	Enoyl-CoA hydratase
sps_RS26015	COG2201	protein-glutamate methylesterase activity
sps_RS26020	COG3706	GGDEF domain
sps_RS26030	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
sps_RS26035	COG0204	Acyl-transferase
sps_RS26065	COG0668	transmembrane transport
sps_RS26070	COG2759	Belongs to the formate--tetrahydrofolate ligase family
sps_RS26085	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
sps_RS26130	COG0745	RESPONSE REGULATOR receiver
sps_RS26150	COG1131	(ABC) transporter
sps_RS26155	COG0842	Transport permease protein
sps_RS26160	COG3385	transposase activity
sps_RS26165	COG1115	amino acid carrier protein
sps_RS26180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
sps_RS26185	COG0798	PFAM Bile acid sodium symporter
sps_RS26190	COG0640	Transcriptional regulator
sps_RS26200	COG0312	modulator of DNA gyrase
sps_RS26225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
sps_RS26235	COG0312	modulator of DNA gyrase
sps_RS26240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
sps_RS26245	COG3164	Protein of unknown function
sps_RS26250	COG1530	ribonuclease E activity
sps_RS26260	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
sps_RS26265	COG1792	Involved in formation and maintenance of cell shape
sps_RS26270	COG1077	Cell shape determining protein MreB Mrl
sps_RS26300	COG2165	general secretion pathway protein
sps_RS26310	COG2165	general secretion pathway protein
sps_RS26315	COG2165	general secretion pathway protein
sps_RS26325	COG1459	type II secretion system
sps_RS26330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
sps_RS26340	COG3267	Type II secretory pathway component ExeA
sps_RS26340	COG3409	Peptidoglycan-binding domain 1 protein
sps_RS26345	COG1450	Type ii and iii secretion system protein
sps_RS26370	COG2199	diguanylate cyclase activity
sps_RS26370	COG2200	EAL domain
sps_RS26375	COG0281	malic enzyme
sps_RS26385	COG0254	rRNA binding
sps_RS26395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
sps_RS26400	COG0018	arginyl-trna synthetase
sps_RS26410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
sps_RS26415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
sps_RS26425	COG1049	propionate catabolic process, 2-methylcitrate cycle
sps_RS26430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
sps_RS26435	COG3590	peptidase
sps_RS26440	COG1752	Esterase of the alpha-beta hydrolase superfamily
sps_RS26445	COG1752	Esterase of the alpha-beta hydrolase superfamily
sps_RS26455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
sps_RS26460	COG0508	dehydrogenase complex catalyzes the overall conversion of
sps_RS26465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
sps_RS26480	COG3023	N-Acetylmuramoyl-L-alanine amidase
sps_RS26495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
sps_RS26500	COG1459	type II secretion system
sps_RS26505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
sps_RS26510	COG0237	dephospho-CoA kinase activity
sps_RS26520	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
sps_RS26525	COG0494	nUDIX hydrolase
sps_RS26535	COG4176	ABC-type proline glycine betaine transport system permease component
sps_RS26540	COG3448	diguanylate cyclase activity
sps_RS26540	COG4175	Glycine betaine
sps_RS26550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
sps_RS26560	COG0792	nuclease activity
sps_RS26565	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
sps_RS26570	COG2823	Periplasmic or secreted lipoprotein
sps_RS26580	COG0583	DNA-binding transcription factor activity
sps_RS26590	COG0180	Tryptophanyl-tRNA synthetase
sps_RS26600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
sps_RS26615	COG0338	D12 class N6 adenine-specific DNA methyltransferase
sps_RS26625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
sps_RS26630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
sps_RS26660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
sps_RS26665	COG0165	Argininosuccinate lyase
sps_RS26670	COG0137	argininosuccinate synthase activity
sps_RS26675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
sps_RS26680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
sps_RS26685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
sps_RS26690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
sps_RS26695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
sps_RS26705	COG1546	Belongs to the CinA family
sps_RS26705	COG1058	Belongs to the CinA family
sps_RS26735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
sps_RS26740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
sps_RS26755	COG0709	Synthesizes selenophosphate from selenide and ATP
sps_RS26760	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
sps_RS26770	COG1218	3'(2'),5'-bisphosphate nucleotidase
sps_RS26775	COG0494	nUDIX hydrolase
sps_RS26780	COG1011	Hydrolase
sps_RS26800	COG3156	type II secretion system protein K
sps_RS26805	COG4795	General secretion pathway protein
sps_RS26810	COG2165	general secretion pathway protein
sps_RS26820	COG2165	general secretion pathway protein
sps_RS26825	COG1459	type II secretion system
sps_RS26830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
sps_RS26845	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
sps_RS26850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
sps_RS26860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
sps_RS26890	COG0671	phosphoesterase, PA-phosphatase related
sps_RS26895	COG0671	phosphoesterase, PA-phosphatase related
sps_RS26905	COG1770	oligopeptidase
sps_RS26910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sps_RS26920	COG1528	Iron-storage protein
sps_RS26935	COG0303	'Molybdopterin
sps_RS26940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
sps_RS26975	COG3220	belongs to the UPF0276 family
sps_RS26985	COG0786	glutamate:sodium symporter activity
sps_RS27000	COG0401	homolog of Blt101
sps_RS27005	COG0564	pseudouridine synthase activity
sps_RS27010	COG0642	Histidine kinase
sps_RS27010	COG3850	Histidine kinase
sps_RS27015	COG0745	RESPONSE REGULATOR receiver
sps_RS27025	COG3111	PFAM Bacterial OB fold (BOF) protein
sps_RS27030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
sps_RS27045	COG0314	molybdopterin synthase activity
sps_RS27050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
sps_RS27055	COG0315	cyclic pyranopterin monophosphate synthase activity
sps_RS27060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
sps_RS27070	COG0840	transmembrane signaling receptor activity
sps_RS27080	COG2258	MOSC domain
sps_RS27085	COG3706	GGDEF domain
sps_RS27090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
sps_RS27095	COG0456	acetyltransferase
sps_RS27100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sps_RS27115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
sps_RS27125	COG0437	4 iron, 4 sulfur cluster binding
sps_RS27130	COG3383	formate dehydrogenase (NAD+) activity
sps_RS27130	COG0243	molybdopterin cofactor binding
sps_RS27160	COG0437	4 iron, 4 sulfur cluster binding
sps_RS27165	COG3383	formate dehydrogenase (NAD+) activity
sps_RS27165	COG0243	molybdopterin cofactor binding
sps_RS27175	COG3381	protein complex oligomerization
sps_RS27210	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
sps_RS27220	COG3161	chorismate lyase activity
sps_RS27235	COG3408	Glycogen debranching enzyme
sps_RS27235	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
sps_RS27240	COG2095	MarC family integral membrane protein
sps_RS27265	COG0204	Acyl-transferase
sps_RS27430	COG4790	Type iii secretion
sps_RS27435	COG4794	Type iii secretion
sps_RS27440	COG4791	protein targeting
sps_RS27445	COG4792	protein secretion
sps_RS27465	COG0668	transmembrane transport
sps_RS27480	COG2986	histidine ammonia-lyase
sps_RS27485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
sps_RS27490	COG2188	Transcriptional regulator
sps_RS27495	COG1228	amidohydrolase
sps_RS27505	COG1917	Cupin 2, conserved barrel domain protein
sps_RS27505	COG4977	sequence-specific DNA binding
sps_RS27530	COG4774	siderophore transport
sps_RS27550	COG2814	Major facilitator Superfamily
sps_RS27560	COG0019	diaminopimelate decarboxylase activity
sps_RS27575	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
sps_RS27600	COG1022	Amp-dependent synthetase and ligase
sps_RS27615	COG2188	Transcriptional regulator
sps_RS27625	COG4555	ABC transporter
sps_RS27630	COG1668	transmembrane transport
sps_RS27655	COG0521	Mo-molybdopterin cofactor biosynthetic process
sps_RS27660	COG0791	NLP P60 protein
sps_RS27665	COG2081	HI0933 family
sps_RS27670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
sps_RS27675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
sps_RS27680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
sps_RS27685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
sps_RS27690	COG4942	peptidase
sps_RS27695	COG0793	Belongs to the peptidase S41A family
sps_RS27705	COG1959	2 iron, 2 sulfur cluster binding
sps_RS27755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
sps_RS27765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
sps_RS27770	COG0573	inorganic phosphate transmembrane transporter activity
sps_RS27775	COG0581	inorganic phosphate transmembrane transporter activity
sps_RS27780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
sps_RS27785	COG0109	protoheme IX farnesyltransferase activity
sps_RS27795	COG1845	cytochrome c oxidase, subunit III
sps_RS27805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
sps_RS27815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
sps_RS27820	COG1349	DNA-binding transcription factor activity
sps_RS27825	COG4774	siderophore transport
sps_RS27830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
sps_RS27845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
sps_RS27850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
sps_RS27855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
sps_RS27860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
sps_RS27865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
sps_RS27870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
sps_RS27880	COG0356	it plays a direct role in the translocation of protons across the membrane
sps_RS27885	COG3312	ion transport
sps_RS27890	COG1475	DNA binding
sps_RS27895	COG1192	Involved in chromosome partitioning
sps_RS27900	COG0357	Ribosomal RNA small subunit methyltransferase G
sps_RS27905	COG0445	tRNA wobble uridine modification