locus-tag	class	description
SPWS13_RS00030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPWS13_RS00040	COG3220	belongs to the UPF0276 family
SPWS13_RS00080	COG0326	Molecular chaperone. Has ATPase activity
SPWS13_RS00085	COG3118	belongs to the thioredoxin family
SPWS13_RS00095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPWS13_RS00105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPWS13_RS00245	COG3772	lysozyme
SPWS13_RS00260	COG4220	transposase activity
SPWS13_RS00280	COG0740	serine-type endopeptidase activity
SPWS13_RS00310	COG3941	tape measure
SPWS13_RS00365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPWS13_RS00380	COG1902	pentaerythritol trinitrate reductase activity
SPWS13_RS00390	COG3082	Protein of unknown function (DUF1414)
SPWS13_RS00400	COG1858	cytochrome C peroxidase
SPWS13_RS00420	COG3102	Protein conserved in bacteria
SPWS13_RS00430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPWS13_RS00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS00475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SPWS13_RS00480	COG1053	succinate dehydrogenase
SPWS13_RS00495	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPWS13_RS00510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPWS13_RS00520	COG0735	belongs to the Fur family
SPWS13_RS00525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPWS13_RS00545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SPWS13_RS00570	COG1301	dicarboxylic acid transport
SPWS13_RS00580	COG3724	N-succinylarginine dihydrolase activity
SPWS13_RS00605	COG1607	acyl-coa hydrolase
SPWS13_RS00610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPWS13_RS00620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPWS13_RS00620	COG0574	Belongs to the PEP-utilizing enzyme family
SPWS13_RS00625	COG0247	lactate metabolic process
SPWS13_RS00625	COG0277	FAD linked oxidase domain protein
SPWS13_RS00660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPWS13_RS00670	COG0482	sulfurtransferase activity
SPWS13_RS00680	COG1187	pseudouridine synthase activity
SPWS13_RS00690	COG1278	Cold shock
SPWS13_RS00700	COG0542	response to heat
SPWS13_RS00705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPWS13_RS00710	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SPWS13_RS00720	COG3134	Outer membrane lipoprotein
SPWS13_RS00740	COG0489	protein tyrosine kinase activity
SPWS13_RS00765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPWS13_RS00780	COG0084	hydrolase, TatD family'
SPWS13_RS00790	COG2715	membrane protein required for spore maturation
SPWS13_RS00795	COG3008	intermembrane lipid transfer
SPWS13_RS00800	COG2995	paraquat-inducible protein a
SPWS13_RS00805	COG2995	paraquat-inducible protein a
SPWS13_RS00810	COG3141	response to X-ray
SPWS13_RS00815	COG1956	GAF domain-containing protein
SPWS13_RS00825	COG0793	Belongs to the peptidase S41A family
SPWS13_RS00830	COG0308	aminopeptidase N
SPWS13_RS00885	COG3784	Protein of unknown function (DUF1318)
SPWS13_RS00920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SPWS13_RS00925	COG0131	Imidazoleglycerol-phosphate dehydratase
SPWS13_RS00925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPWS13_RS00930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPWS13_RS00935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPWS13_RS00950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPWS13_RS00955	COG0583	DNA-binding transcription factor activity
SPWS13_RS00975	COG1760	l-serine dehydratase
SPWS13_RS01000	COG3344	reverse transcriptase
SPWS13_RS01015	COG0517	IMP dehydrogenase activity
SPWS13_RS01020	COG4974	Belongs to the 'phage' integrase family
SPWS13_RS01035	COG1254	Belongs to the acylphosphatase family
SPWS13_RS01055	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPWS13_RS01085	COG1959	2 iron, 2 sulfur cluster binding
SPWS13_RS01095	COG0822	iron-sulfur transferase activity
SPWS13_RS01100	COG0316	Belongs to the HesB IscA family
SPWS13_RS01105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SPWS13_RS01125	COG2975	iron-sulfur cluster assembly
SPWS13_RS01140	COG0071	Belongs to the small heat shock protein (HSP20) family
SPWS13_RS01150	COG0028	Belongs to the TPP enzyme family
SPWS13_RS01160	COG2814	Major facilitator Superfamily
SPWS13_RS01170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPWS13_RS01210	COG0288	reversible hydration of carbon dioxide
SPWS13_RS01220	COG1876	peptidase activity
SPWS13_RS01230	COG1393	Belongs to the ArsC family
SPWS13_RS01250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPWS13_RS01260	COG0840	transmembrane signaling receptor activity
SPWS13_RS01270	COG1199	ATP-dependent helicase activity
SPWS13_RS01270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPWS13_RS01280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPWS13_RS01305	COG0714	Associated with various cellular activities
SPWS13_RS01320	COG1322	Protein conserved in bacteria
SPWS13_RS01325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPWS13_RS01335	COG0346	lactoylglutathione lyase activity
SPWS13_RS01350	COG1505	serine-type exopeptidase activity
SPWS13_RS01365	COG0589	response to stress
SPWS13_RS01375	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SPWS13_RS01385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SPWS13_RS01390	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SPWS13_RS01425	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS01445	COG0252	asparaginase activity
SPWS13_RS01455	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPWS13_RS01455	COG1902	pentaerythritol trinitrate reductase activity
SPWS13_RS01465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPWS13_RS01475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPWS13_RS01500	COG1069	ribulokinase activity
SPWS13_RS01515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPWS13_RS01520	COG2186	Transcriptional regulator
SPWS13_RS01525	COG3507	Belongs to the glycosyl hydrolase 43 family
SPWS13_RS01540	COG2017	converts alpha-aldose to the beta-anomer
SPWS13_RS01545	COG1879	ABC-type sugar transport system periplasmic component
SPWS13_RS01550	COG1129	ABC transporter
SPWS13_RS01555	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPWS13_RS01565	COG3940	Belongs to the glycosyl hydrolase 43 family
SPWS13_RS01585	COG3507	Belongs to the glycosyl hydrolase 43 family
SPWS13_RS01590	COG3940	Belongs to the glycosyl hydrolase 43 family
SPWS13_RS01605	COG3507	Belongs to the glycosyl hydrolase 43 family
SPWS13_RS01615	COG1448	Aminotransferase
SPWS13_RS01620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPWS13_RS01630	COG0539	negative regulation of cytoplasmic translation
SPWS13_RS01640	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
SPWS13_RS01645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SPWS13_RS01650	COG0284	orotidine-5'-phosphate decarboxylase activity
SPWS13_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS01660	COG3122	Protein conserved in bacteria
SPWS13_RS01665	COG1960	acyl-CoA dehydrogenase activity
SPWS13_RS01685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPWS13_RS01690	COG2814	Major facilitator Superfamily
SPWS13_RS01700	COG3148	PFAM DTW domain containing protein
SPWS13_RS01715	COG0514	ATP-dependent DNA helicase (RecQ)
SPWS13_RS01725	COG4574	serine-type endopeptidase inhibitor activity
SPWS13_RS01740	COG0534	Mate efflux family protein
SPWS13_RS01745	COG0307	riboflavin synthase, alpha
SPWS13_RS01765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPWS13_RS01770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPWS13_RS01775	COG0492	ferredoxin-NADP+ reductase activity
SPWS13_RS01780	COG0686	Belongs to the AlaDH PNT family
SPWS13_RS01800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPWS13_RS01810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPWS13_RS01820	COG2920	part of a sulfur-relay system
SPWS13_RS01840	COG0670	Belongs to the BI1 family
SPWS13_RS01845	COG0583	DNA-binding transcription factor activity
SPWS13_RS01850	COG2814	Major facilitator Superfamily
SPWS13_RS01880	COG3278	Belongs to the heme-copper respiratory oxidase family
SPWS13_RS01920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPWS13_RS01925	COG0589	response to stress
SPWS13_RS01940	COG2992	FlgJ-related protein
SPWS13_RS01955	COG3139	Protein of unknown function (DUF1315)
SPWS13_RS01965	COG2866	Carboxypeptidase
SPWS13_RS01970	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS01980	COG2255	four-way junction helicase activity
SPWS13_RS01995	COG0217	transcriptional regulatory protein
SPWS13_RS02040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPWS13_RS02055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPWS13_RS02065	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPWS13_RS02075	COG1272	protein, Hemolysin III
SPWS13_RS02085	COG0494	nUDIX hydrolase
SPWS13_RS02110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPWS13_RS02145	COG2850	peptidyl-arginine hydroxylation
SPWS13_RS02160	COG3005	denitrification pathway
SPWS13_RS02165	COG3043	anaerobic respiration
SPWS13_RS02170	COG0243	molybdopterin cofactor binding
SPWS13_RS02175	COG3062	negative regulation of establishment of protein localization
SPWS13_RS02185	COG1643	Atp-dependent helicase
SPWS13_RS02220	COG3108	Peptidase M15
SPWS13_RS02225	COG2989	Protein conserved in bacteria
SPWS13_RS02255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPWS13_RS02265	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPWS13_RS02270	COG0022	dehydrogenase e1 component
SPWS13_RS02275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPWS13_RS02285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPWS13_RS02295	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
SPWS13_RS02300	COG0596	Alpha beta hydrolase
SPWS13_RS02335	COG1757	Na H antiporter
SPWS13_RS02340	COG0436	Aminotransferase
SPWS13_RS02345	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SPWS13_RS02355	COG0800	Aldolase
SPWS13_RS02360	COG0129	dihydroxy-acid dehydratase activity
SPWS13_RS02365	COG0363	glucosamine-6-phosphate deaminase activity
SPWS13_RS02375	COG1737	Transcriptional regulator
SPWS13_RS02380	COG0469	pyruvate kinase activity
SPWS13_RS02440	COG0602	queuosine metabolic process
SPWS13_RS02455	COG0556	nucleotide-excision repair
SPWS13_RS02500	COG2878	Part of a membrane complex involved in electron transport
SPWS13_RS02510	COG4658	electron transport chain
SPWS13_RS02525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPWS13_RS02550	COG0488	(ABC) transporter
SPWS13_RS02560	COG0045	succinate-CoA ligase (ADP-forming) activity
SPWS13_RS02560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPWS13_RS02560	COG1042	CoA-binding domain protein
SPWS13_RS02565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SPWS13_RS02570	COG0298	carbon dioxide binding
SPWS13_RS02575	COG0409	Hydrogenase expression formation protein
SPWS13_RS02580	COG0309	Hydrogenase expression formation protein (HypE)
SPWS13_RS02590	COG1560	Kdo2-lipid A biosynthetic process
SPWS13_RS02600	COG0072	phenylalanine-tRNA ligase activity
SPWS13_RS02600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPWS13_RS02615	COG4771	TonB-dependent receptor
SPWS13_RS02665	COG0583	DNA-binding transcription factor activity
SPWS13_RS02675	COG2814	Major facilitator Superfamily
SPWS13_RS02730	COG2003	Belongs to the UPF0758 family
SPWS13_RS02780	COG2095	MarC family integral membrane protein
SPWS13_RS02800	COG1506	peptidase
SPWS13_RS02800	COG0823	Involved in the tonB-independent uptake of proteins
SPWS13_RS02810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPWS13_RS02845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPWS13_RS02845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPWS13_RS02865	COG0242	peptide deformylase activity
SPWS13_RS02930	COG2885	chlorophyll binding
SPWS13_RS02950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPWS13_RS02965	COG2226	methyltransferase
SPWS13_RS02970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPWS13_RS02990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SPWS13_RS03005	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS03010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPWS13_RS03030	COG2894	cell division
SPWS13_RS03040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SPWS13_RS03045	COG0318	PFAM AMP-dependent synthetase and ligase
SPWS13_RS03050	COG2267	carboxylic ester hydrolase activity
SPWS13_RS03070	COG1214	PFAM Peptidase M22, glycoprotease
SPWS13_RS03075	COG0113	porphobilinogen synthase activity
SPWS13_RS03080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPWS13_RS03090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPWS13_RS03105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPWS13_RS03115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPWS13_RS03120	COG0583	DNA-binding transcription factor activity
SPWS13_RS03130	COG0189	ligase activity
SPWS13_RS03160	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS03165	COG2205	protein histidine kinase activity
SPWS13_RS03170	COG0626	cystathionine gamma-synthase activity
SPWS13_RS03180	COG0443	Heat shock 70 kDa protein
SPWS13_RS03185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPWS13_RS03190	COG0248	Ppx GppA phosphatase
SPWS13_RS03200	COG0583	DNA-binding transcription factor activity
SPWS13_RS03215	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS03220	COG1575	Belongs to the MenA family. Type 1 subfamily
SPWS13_RS03225	COG3384	dioxygenase
SPWS13_RS03250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPWS13_RS03255	COG2076	Multidrug Resistance protein
SPWS13_RS03270	COG1960	acyl-CoA dehydrogenase activity
SPWS13_RS03275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPWS13_RS03280	COG1024	Enoyl-CoA hydratase
SPWS13_RS03285	COG4770	biotin carboxylase activity
SPWS13_RS03295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPWS13_RS03300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SPWS13_RS03330	COG2133	pyrroloquinoline quinone binding
SPWS13_RS03350	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SPWS13_RS03360	COG2716	regulation of RNA biosynthetic process
SPWS13_RS03370	COG1279	arginine transmembrane transporter activity
SPWS13_RS03390	COG4783	chaperone-mediated protein folding
SPWS13_RS03395	COG1393	Belongs to the ArsC family
SPWS13_RS03410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPWS13_RS03425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SPWS13_RS03435	COG2766	serine protein kinase
SPWS13_RS03445	COG2719	SpoVR family
SPWS13_RS03450	COG2186	Transcriptional regulator
SPWS13_RS03455	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPWS13_RS03500	COG0583	DNA-binding transcription factor activity
SPWS13_RS03505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SPWS13_RS03515	COG1280	lysine exporter protein (LysE YggA)
SPWS13_RS03535	COG0778	Nitroreductase
SPWS13_RS03575	COG0813	purine-nucleoside phosphorylase activity
SPWS13_RS03600	COG0537	adenosine 5'-monophosphoramidase activity
SPWS13_RS03625	COG0259	pyridoxamine-phosphate oxidase activity
SPWS13_RS03650	COG3132	Protein of unknown function, DUF480
SPWS13_RS03685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPWS13_RS03710	COG1067	ATP-dependent peptidase activity
SPWS13_RS03720	COG3130	regulation of translation
SPWS13_RS03730	COG0488	(ABC) transporter
SPWS13_RS03740	COG0116	Belongs to the methyltransferase superfamily
SPWS13_RS03740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPWS13_RS03765	COG0484	heat shock protein binding
SPWS13_RS03855	COG0339	signal peptide processing
SPWS13_RS03865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
SPWS13_RS03900	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
SPWS13_RS03905	COG2885	chlorophyll binding
SPWS13_RS03925	COG0811	peptide transport
SPWS13_RS03930	COG0824	Thioesterase
SPWS13_RS03935	COG1505	serine-type exopeptidase activity
SPWS13_RS03940	COG2885	chlorophyll binding
SPWS13_RS03945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPWS13_RS03950	COG0450	alkyl hydroperoxide reductase
SPWS13_RS03955	COG2056	Na+-H+ antiporter family
SPWS13_RS03970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPWS13_RS03975	COG0647	UMP catabolic process
SPWS13_RS03985	COG2234	aminopeptidase activity
SPWS13_RS03990	COG0367	asparagine synthase
SPWS13_RS03995	COG4667	esterase of the alpha-beta hydrolase superfamily
SPWS13_RS04005	COG1960	acyl-CoA dehydrogenase activity
SPWS13_RS04015	COG2084	Dehydrogenase
SPWS13_RS04020	COG1607	acyl-coa hydrolase
SPWS13_RS04030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPWS13_RS04035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPWS13_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS04050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPWS13_RS04065	COG1399	metal-binding, possibly nucleic acid-binding protein
SPWS13_RS04070	COG0424	maF-like protein
SPWS13_RS04090	COG1278	Cold shock
SPWS13_RS04095	COG2226	methyltransferase
SPWS13_RS04105	COG2925	Exonuclease
SPWS13_RS04170	COG2333	competence protein COMEC
SPWS13_RS04170	COG0658	competence protein
SPWS13_RS04215	COG1966	Carbon starvation protein
SPWS13_RS04260	COG1752	Esterase of the alpha-beta hydrolase superfamily
SPWS13_RS04265	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS04275	COG1451	nucleotide metabolic process
SPWS13_RS04295	COG0420	3'-5' exonuclease activity
SPWS13_RS04325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPWS13_RS04390	COG0730	response to heat
SPWS13_RS04415	COG1555	photosystem II stabilization
SPWS13_RS04415	COG1596	polysaccharide export
SPWS13_RS04425	COG3768	UPF0283 membrane protein
SPWS13_RS04445	COG1842	Phage shock protein A
SPWS13_RS04450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SPWS13_RS04455	COG0747	negative chemotaxis
SPWS13_RS04460	COG4168	peptide transport system, permease
SPWS13_RS04485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPWS13_RS04530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPWS13_RS04535	COG0215	cysteine-tRNA ligase activity
SPWS13_RS04540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPWS13_RS04560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPWS13_RS04605	COG3835	regulator
SPWS13_RS04620	COG1929	Belongs to the glycerate kinase type-1 family
SPWS13_RS04730	COG0318	PFAM AMP-dependent synthetase and ligase
SPWS13_RS04735	COG0596	Alpha beta hydrolase
SPWS13_RS04740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPWS13_RS04760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPWS13_RS04790	COG0573	inorganic phosphate transmembrane transporter activity
SPWS13_RS04850	COG0427	acetyl-CoA hydrolase
SPWS13_RS04860	COG1131	(ABC) transporter
SPWS13_RS04870	COG1309	transcriptional regulator
SPWS13_RS04890	COG4249	Peptidase C14 caspase catalytic subunit p20
SPWS13_RS04890	COG2319	Wd-40 repeat
SPWS13_RS04910	COG4251	negative regulation of phosphorylation
SPWS13_RS04910	COG2203	Gaf domain
SPWS13_RS04910	COG3706	GGDEF domain
SPWS13_RS04910	COG5001	Diguanylate cyclase
SPWS13_RS04925	COG0488	(ABC) transporter
SPWS13_RS04935	COG0789	Transcriptional regulator
SPWS13_RS04960	COG1024	Enoyl-CoA hydratase
SPWS13_RS04965	COG1024	Enoyl-CoA hydratase
SPWS13_RS04970	COG1960	acyl-CoA dehydrogenase activity
SPWS13_RS04985	COG0840	transmembrane signaling receptor activity
SPWS13_RS05005	COG3047	cAMP biosynthetic process
SPWS13_RS05015	COG0625	glutathione transferase activity
SPWS13_RS05040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPWS13_RS05045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPWS13_RS05050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SPWS13_RS05050	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SPWS13_RS05095	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SPWS13_RS05125	COG1278	Cold shock
SPWS13_RS05130	COG3706	GGDEF domain
SPWS13_RS05135	COG0037	tRNA processing
SPWS13_RS05140	COG0587	DNA-directed DNA polymerase activity
SPWS13_RS05155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SPWS13_RS05170	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
SPWS13_RS05180	COG0750	zinc metalloprotease
SPWS13_RS05190	COG0575	Belongs to the CDS family
SPWS13_RS05195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPWS13_RS05205	COG0528	UMP kinase activity
SPWS13_RS05210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPWS13_RS05220	COG0024	Methionine aminopeptidase
SPWS13_RS05225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SPWS13_RS05240	COG0788	formyltetrahydrofolate deformylase activity
SPWS13_RS05250	COG0716	FMN binding
SPWS13_RS05260	COG0564	pseudouridine synthase activity
SPWS13_RS05265	COG3098	single-species biofilm formation
SPWS13_RS05300	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
SPWS13_RS05385	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPWS13_RS05390	COG0840	transmembrane signaling receptor activity
SPWS13_RS05400	COG1846	Transcriptional regulator
SPWS13_RS05405	COG2807	transmembrane transport
SPWS13_RS05410	COG2824	Alkylphosphonate utilization operon protein PhnA
SPWS13_RS05415	COG1629	transport
SPWS13_RS05425	COG0625	glutathione transferase activity
SPWS13_RS05450	COG2239	Acts as a magnesium transporter
SPWS13_RS05455	COG0386	Belongs to the glutathione peroxidase family
SPWS13_RS05470	COG5002	protein histidine kinase activity
SPWS13_RS05505	COG1611	Belongs to the LOG family
SPWS13_RS05510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPWS13_RS05520	COG0823	Involved in the tonB-independent uptake of proteins
SPWS13_RS05520	COG1506	peptidase
SPWS13_RS05520	COG4946	Tricorn protease homolog
SPWS13_RS05525	COG0473	3-isopropylmalate dehydrogenase activity
SPWS13_RS05535	COG2363	Small membrane protein
SPWS13_RS05545	COG0583	DNA-binding transcription factor activity
SPWS13_RS05560	COG1360	Flagellar Motor Protein
SPWS13_RS05565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SPWS13_RS05570	COG1722	exodeoxyribonuclease VII activity
SPWS13_RS05575	COG0142	geranyltranstransferase activity
SPWS13_RS05595	COG1620	l-lactate permease
SPWS13_RS05605	COG0247	lactate metabolic process
SPWS13_RS05610	COG1139	Iron-sulfur cluster binding protein
SPWS13_RS05620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPWS13_RS05625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPWS13_RS05670	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS05705	COG1640	4-alpha-glucanotransferase
SPWS13_RS05710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPWS13_RS05720	COG1454	alcohol dehydrogenase
SPWS13_RS05730	COG1252	NADH dehydrogenase
SPWS13_RS05740	COG1607	acyl-coa hydrolase
SPWS13_RS05750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SPWS13_RS05780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPWS13_RS05785	COG2914	Belongs to the UPF0125 (RnfH) family
SPWS13_RS05790	COG2867	negative regulation of translational initiation
SPWS13_RS05820	COG2003	Belongs to the UPF0758 family
SPWS13_RS05845	COG0589	response to stress
SPWS13_RS05865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPWS13_RS05880	COG0640	Transcriptional regulator
SPWS13_RS05885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPWS13_RS05905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SPWS13_RS05915	COG2176	DNA-directed DNA polymerase activity
SPWS13_RS05945	COG2964	Protein conserved in bacteria
SPWS13_RS05970	COG2311	Membrane
SPWS13_RS05980	COG2031	fatty acid transporter
SPWS13_RS05985	COG0545	Peptidyl-prolyl cis-trans isomerase
SPWS13_RS06005	COG0840	transmembrane signaling receptor activity
SPWS13_RS06010	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS06030	COG0693	protein deglycase activity
SPWS13_RS06055	COG2268	Band 7 protein
SPWS13_RS06085	COG0795	lipopolysaccharide-transporting ATPase activity
SPWS13_RS06090	COG0795	lipopolysaccharide-transporting ATPase activity
SPWS13_RS06095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPWS13_RS06100	COG0077	Prephenate dehydratase
SPWS13_RS06100	COG1605	Chorismate mutase
SPWS13_RS06110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPWS13_RS06120	COG1605	Chorismate mutase
SPWS13_RS06120	COG0287	Prephenate dehydrogenase
SPWS13_RS06125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPWS13_RS06130	COG0335	large ribosomal subunit rRNA binding
SPWS13_RS06150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPWS13_RS06155	COG4137	Cytochrome C assembly protein
SPWS13_RS06160	COG4536	flavin adenine dinucleotide binding
SPWS13_RS06170	COG0736	holo-[acyl-carrier-protein] synthase activity
SPWS13_RS06175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SPWS13_RS06200	COG0481	GTPase activity
SPWS13_RS06210	COG3026	antisigma factor binding
SPWS13_RS06220	COG1595	DNA-templated transcription, initiation
SPWS13_RS06225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SPWS13_RS06235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SPWS13_RS06265	COG0730	response to heat
SPWS13_RS06290	COG0583	DNA-binding transcription factor activity
SPWS13_RS06295	COG2198	Histidine kinase
SPWS13_RS06295	COG0784	Response regulator, receiver
SPWS13_RS06295	COG5002	protein histidine kinase activity
SPWS13_RS06300	COG1242	4 iron, 4 sulfur cluster binding
SPWS13_RS06305	COG0069	glutamate synthase activity
SPWS13_RS06305	COG0067	glutamate synthase
SPWS13_RS06305	COG0070	glutamate synthase
SPWS13_RS06310	COG0493	'glutamate synthase
SPWS13_RS06315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPWS13_RS06345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SPWS13_RS06350	COG4942	peptidase
SPWS13_RS06385	COG0540	Belongs to the ATCase OTCase family
SPWS13_RS06420	COG2226	methyltransferase
SPWS13_RS06430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPWS13_RS06435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPWS13_RS06445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPWS13_RS06450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SPWS13_RS06455	COG1610	YqeY-like protein
SPWS13_RS06485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPWS13_RS06490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SPWS13_RS06495	COG1012	belongs to the aldehyde dehydrogenase family
SPWS13_RS06500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPWS13_RS06505	COG1177	transmembrane transport
SPWS13_RS06515	COG3842	ATPase activity
SPWS13_RS06530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPWS13_RS06550	COG2897	thiosulfate sulfurtransferase activity
SPWS13_RS06555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SPWS13_RS06570	COG1012	belongs to the aldehyde dehydrogenase family
SPWS13_RS06605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPWS13_RS06650	COG4969	Belongs to the N-Me-Phe pilin family
SPWS13_RS06690	COG1047	Peptidyl-prolyl cis-trans
SPWS13_RS06700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPWS13_RS06705	COG0196	riboflavin kinase activity
SPWS13_RS06720	COG0640	Transcriptional regulator
SPWS13_RS06735	COG1115	amino acid carrier protein
SPWS13_RS06790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPWS13_RS06800	COG2203	Gaf domain
SPWS13_RS06800	COG2199	diguanylate cyclase activity
SPWS13_RS06815	COG2918	glutathione biosynthetic process
SPWS13_RS06830	COG1301	dicarboxylic acid transport
SPWS13_RS06845	COG3630	sodium ion export across plasma membrane
SPWS13_RS06870	COG1183	phosphatidylcholine synthase activity
SPWS13_RS06880	COG0542	response to heat
SPWS13_RS06890	COG0564	pseudouridine synthase activity
SPWS13_RS06895	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPWS13_RS06945	COG1584	GPR1 FUN34 yaaH family protein
SPWS13_RS06965	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS06975	COG3313	Fe-S protein
SPWS13_RS07000	COG4208	sulfate ABC transporter
SPWS13_RS07010	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SPWS13_RS07015	COG0564	pseudouridine synthase activity
SPWS13_RS07030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPWS13_RS07045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPWS13_RS07050	COG3178	'Phosphotransferase
SPWS13_RS07070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SPWS13_RS07085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPWS13_RS07105	COG3610	response to peptide
SPWS13_RS07110	COG2966	Psort location CytoplasmicMembrane, score
SPWS13_RS07120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPWS13_RS07130	COG0142	geranyltranstransferase activity
SPWS13_RS07135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPWS13_RS07150	COG1280	lysine exporter protein (LysE YggA)
SPWS13_RS07160	COG3604	Transcriptional regulator
SPWS13_RS07165	COG0348	domain, Protein
SPWS13_RS07175	COG1132	(ABC) transporter
SPWS13_RS07180	COG0748	coenzyme F420 binding
SPWS13_RS07195	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPWS13_RS07200	COG0811	peptide transport
SPWS13_RS07205	COG0848	biopolymer transport protein
SPWS13_RS07215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPWS13_RS07220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SPWS13_RS07250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPWS13_RS07270	COG0697	spore germination
SPWS13_RS07275	COG0583	DNA-binding transcription factor activity
SPWS13_RS07290	COG2193	ferroxidase activity
SPWS13_RS07300	COG2991	Protein conserved in bacteria
SPWS13_RS07305	COG1477	protein flavinylation
SPWS13_RS07310	COG2871	sodium ion transport
SPWS13_RS07315	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SPWS13_RS07325	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SPWS13_RS07330	COG1805	sodium ion transport
SPWS13_RS07335	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SPWS13_RS07350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SPWS13_RS07355	COG0271	Belongs to the BolA IbaG family
SPWS13_RS07365	COG2813	Specifically methylates the guanine in position
SPWS13_RS07375	COG2873	o-acetylhomoserine
SPWS13_RS07380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPWS13_RS07385	COG1271	oxidase subunit
SPWS13_RS07390	COG1294	oxidase, subunit
SPWS13_RS07400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPWS13_RS07410	COG0697	spore germination
SPWS13_RS07415	COG0840	transmembrane signaling receptor activity
SPWS13_RS07420	COG1757	Na H antiporter
SPWS13_RS07430	COG1187	pseudouridine synthase activity
SPWS13_RS07445	COG3591	Belongs to the peptidase S1B family
SPWS13_RS07445	COG4990	cell redox homeostasis
SPWS13_RS07450	COG0814	amino acid
SPWS13_RS07460	COG2119	membrane
SPWS13_RS07480	COG0387	Pfam Sodium calcium exchanger
SPWS13_RS07510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPWS13_RS07545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPWS13_RS07570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPWS13_RS07575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SPWS13_RS07580	COG4974	Belongs to the 'phage' integrase family
SPWS13_RS07595	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS07655	COG0191	fructose-bisphosphate aldolase activity
SPWS13_RS07670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPWS13_RS07675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPWS13_RS07800	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SPWS13_RS07805	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SPWS13_RS07815	COG1805	sodium ion transport
SPWS13_RS07825	COG0667	Aldo Keto reductase
SPWS13_RS07830	COG3713	MltA-interacting MipA family protein
SPWS13_RS07845	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS07870	COG2166	iron-sulfur cluster assembly
SPWS13_RS07890	COG0826	peptidase U32
SPWS13_RS07895	COG0564	pseudouridine synthase activity
SPWS13_RS07905	COG1404	Belongs to the peptidase S8 family
SPWS13_RS07910	COG0842	Transport permease protein
SPWS13_RS07915	COG1131	(ABC) transporter
SPWS13_RS07930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPWS13_RS07970	COG2211	Major facilitator Superfamily
SPWS13_RS07985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SPWS13_RS07995	COG2200	EAL domain
SPWS13_RS08015	COG1053	succinate dehydrogenase
SPWS13_RS08055	COG2890	protein-(glutamine-N5) methyltransferase activity
SPWS13_RS08075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPWS13_RS08080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPWS13_RS08105	COG1187	pseudouridine synthase activity
SPWS13_RS08110	COG3590	peptidase
SPWS13_RS08140	COG4807	Protein conserved in bacteria
SPWS13_RS08155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPWS13_RS08165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPWS13_RS08170	COG4191	Histidine kinase
SPWS13_RS08170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPWS13_RS08195	COG3422	double-strand break repair
SPWS13_RS08210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPWS13_RS08215	COG4974	Belongs to the 'phage' integrase family
SPWS13_RS08375	COG3209	COG3209 Rhs family protein
SPWS13_RS08420	COG0270	DNA (cytosine-5-)-methyltransferase activity
SPWS13_RS08475	COG3150	esterase
SPWS13_RS08480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SPWS13_RS08490	COG0494	nUDIX hydrolase
SPWS13_RS08495	COG1538	Outer membrane efflux protein
SPWS13_RS08515	COG1024	Enoyl-CoA hydratase
SPWS13_RS08535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPWS13_RS08565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPWS13_RS08590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPWS13_RS08595	COG0557	exoribonuclease II activity
SPWS13_RS08600	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SPWS13_RS08605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPWS13_RS08610	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
SPWS13_RS08615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPWS13_RS08625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SPWS13_RS08630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPWS13_RS08660	COG4208	sulfate ABC transporter
SPWS13_RS08665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SPWS13_RS08690	COG5007	Belongs to the BolA IbaG family
SPWS13_RS08700	COG2854	intermembrane phospholipid transfer
SPWS13_RS08705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SPWS13_RS08710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPWS13_RS08720	COG0517	IMP dehydrogenase activity
SPWS13_RS08720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SPWS13_RS08725	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SPWS13_RS08755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPWS13_RS08765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPWS13_RS08810	COG0534	Mate efflux family protein
SPWS13_RS08825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPWS13_RS08835	COG1280	lysine exporter protein (LysE YggA)
SPWS13_RS08870	COG1342	Belongs to the UPF0251 family
SPWS13_RS08880	COG1119	ATPase activity
SPWS13_RS08895	COG2197	response regulator
SPWS13_RS08900	COG3112	Uncharacterised protein family (UPF0231)
SPWS13_RS08905	COG0598	Magnesium transport protein CorA
SPWS13_RS08910	COG0527	aspartate kinase activity
SPWS13_RS08920	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS08930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SPWS13_RS08935	COG2131	deaminase
SPWS13_RS08955	COG0840	transmembrane signaling receptor activity
SPWS13_RS08960	COG1301	dicarboxylic acid transport
SPWS13_RS09030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPWS13_RS09035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPWS13_RS09045	COG5001	Diguanylate cyclase
SPWS13_RS09045	COG5002	protein histidine kinase activity
SPWS13_RS09055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPWS13_RS09090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPWS13_RS09115	COG0629	single-stranded DNA binding
SPWS13_RS09120	COG2814	Major facilitator Superfamily
SPWS13_RS09125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPWS13_RS09130	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS09140	COG0546	phosphoglycolate phosphatase activity
SPWS13_RS09175	COG3258	Cytochrome c
SPWS13_RS09180	COG2863	cytochrome
SPWS13_RS09200	COG0840	transmembrane signaling receptor activity
SPWS13_RS09210	COG0527	aspartate kinase activity
SPWS13_RS09210	COG0460	homoserine dehydrogenase
SPWS13_RS09215	COG0626	cystathionine gamma-synthase activity
SPWS13_RS09220	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
SPWS13_RS09230	COG3301	Polysulphide reductase, NrfD
SPWS13_RS09235	COG0437	4 iron, 4 sulfur cluster binding
SPWS13_RS09255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPWS13_RS09305	COG4773	Receptor
SPWS13_RS09310	COG2226	methyltransferase
SPWS13_RS09315	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SPWS13_RS09355	COG3028	Belongs to the UPF0307 family
SPWS13_RS09365	COG1285	pathogenesis
SPWS13_RS09385	COG0531	amino acid
SPWS13_RS09405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS09415	COG0312	modulator of DNA gyrase
SPWS13_RS09420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPWS13_RS09430	COG1530	ribonuclease E activity
SPWS13_RS09440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SPWS13_RS09445	COG1792	Involved in formation and maintenance of cell shape
SPWS13_RS09450	COG1077	Cell shape determining protein MreB Mrl
SPWS13_RS09485	COG2165	general secretion pathway protein
SPWS13_RS09565	COG0281	malic enzyme
SPWS13_RS09580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPWS13_RS09600	COG0330	HflC and HflK could
SPWS13_RS09605	COG0330	HflC and HflK could
SPWS13_RS09620	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPWS13_RS09625	COG2841	Protein conserved in bacteria
SPWS13_RS09640	COG0668	transmembrane transport
SPWS13_RS09680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPWS13_RS09685	COG2165	general secretion pathway protein
SPWS13_RS09690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SPWS13_RS09720	COG3046	protein related to deoxyribodipyrimidine photolyase
SPWS13_RS09735	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SPWS13_RS09745	COG0564	pseudouridine synthase activity
SPWS13_RS09765	COG1227	inorganic diphosphatase activity
SPWS13_RS09775	COG0840	transmembrane signaling receptor activity
SPWS13_RS09800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SPWS13_RS09805	COG0010	Belongs to the arginase family
SPWS13_RS09835	COG0805	protein transport
SPWS13_RS09845	COG0084	hydrolase, TatD family'
SPWS13_RS09920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SPWS13_RS09925	COG0849	cell division
SPWS13_RS09930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPWS13_RS09945	COG0772	Belongs to the SEDS family
SPWS13_RS09960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPWS13_RS09965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPWS13_RS09970	COG0768	penicillin binding
SPWS13_RS09975	COG3116	cell division
SPWS13_RS10000	COG2067	long-chain fatty acid transport protein
SPWS13_RS10015	COG0473	3-isopropylmalate dehydrogenase activity
SPWS13_RS10030	COG0514	ATP-dependent DNA helicase (RecQ)
SPWS13_RS10040	COG2962	Rard protein
SPWS13_RS10050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPWS13_RS10050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPWS13_RS10060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPWS13_RS10070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPWS13_RS10085	COG1506	peptidase
SPWS13_RS10095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPWS13_RS10110	COG1561	YicC-like family, N-terminal region
SPWS13_RS10140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPWS13_RS10160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPWS13_RS10165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPWS13_RS10220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPWS13_RS10225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPWS13_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS10235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPWS13_RS10265	COG0454	-acetyltransferase
SPWS13_RS10270	COG3135	benzoate transporter
SPWS13_RS10275	COG1396	sequence-specific DNA binding
SPWS13_RS10295	COG0456	acetyltransferase
SPWS13_RS10315	COG0348	domain, Protein
SPWS13_RS10325	COG4251	negative regulation of phosphorylation
SPWS13_RS10325	COG2203	Gaf domain
SPWS13_RS10325	COG3706	GGDEF domain
SPWS13_RS10325	COG5001	Diguanylate cyclase
SPWS13_RS10330	COG1217	gtp-binding protein TYPA
SPWS13_RS10335	COG0174	glutamine synthetase
SPWS13_RS10355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPWS13_RS10390	COG0401	homolog of Blt101
SPWS13_RS10395	COG0564	pseudouridine synthase activity
SPWS13_RS10400	COG5002	protein histidine kinase activity
SPWS13_RS10405	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS10415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SPWS13_RS10430	COG0314	molybdopterin synthase activity
SPWS13_RS10435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SPWS13_RS10455	COG0840	transmembrane signaling receptor activity
SPWS13_RS10465	COG2258	MOSC domain
SPWS13_RS10470	COG3706	GGDEF domain
SPWS13_RS10485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPWS13_RS10500	COG1309	transcriptional regulator
SPWS13_RS10505	COG1979	alcohol dehydrogenase
SPWS13_RS10545	COG3678	ATP-independent chaperone mediated protein folding
SPWS13_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS10620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPWS13_RS10620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPWS13_RS10630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPWS13_RS10635	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
SPWS13_RS10645	COG3290	protein histidine kinase activity
SPWS13_RS10695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPWS13_RS10700	COG4235	cytochrome complex assembly
SPWS13_RS10700	COG3088	subunit of a heme lyase
SPWS13_RS10715	COG4235	cytochrome complex assembly
SPWS13_RS10715	COG3088	subunit of a heme lyase
SPWS13_RS10730	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPWS13_RS10735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPWS13_RS10740	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPWS13_RS10765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPWS13_RS10775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPWS13_RS10810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPWS13_RS10840	COG0255	Belongs to the universal ribosomal protein uL29 family
SPWS13_RS10845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPWS13_RS10855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPWS13_RS10860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPWS13_RS10870	COG0089	rRNA binding
SPWS13_RS10890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPWS13_RS11025	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SPWS13_RS11055	COG0109	protoheme IX farnesyltransferase activity
SPWS13_RS11065	COG0726	polysaccharide deacetylase
SPWS13_RS11070	COG0534	Mate efflux family protein
SPWS13_RS11105	COG1053	succinate dehydrogenase
SPWS13_RS11105	COG3976	FMN-binding domain protein
SPWS13_RS11120	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS11130	COG1040	competence protein
SPWS13_RS11145	COG1368	sulfuric ester hydrolase activity
SPWS13_RS11150	COG2183	response to ionizing radiation
SPWS13_RS11155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPWS13_RS11200	COG3064	Membrane
SPWS13_RS11245	COG4773	Receptor
SPWS13_RS11265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SPWS13_RS11270	COG2855	membrane
SPWS13_RS11295	COG1169	isochorismate synthase
SPWS13_RS11305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SPWS13_RS11315	COG3852	Histidine kinase
SPWS13_RS11320	COG2204	response regulator
SPWS13_RS11340	COG0746	molybdenum cofactor guanylyltransferase activity
SPWS13_RS11350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPWS13_RS11370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPWS13_RS11390	COG0463	Glycosyl transferase, family 2
SPWS13_RS11415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPWS13_RS11435	COG0859	PFAM glycosyl transferase family 9
SPWS13_RS11440	COG3642	lipopolysaccharide core region biosynthetic process
SPWS13_RS11460	COG1063	alcohol dehydrogenase
SPWS13_RS11465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPWS13_RS11475	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
SPWS13_RS11505	COG3078	GTPase activator activity
SPWS13_RS11515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPWS13_RS11530	COG2267	carboxylic ester hydrolase activity
SPWS13_RS11555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SPWS13_RS11585	COG0551	DNA topoisomerase type I activity
SPWS13_RS11595	COG0758	DNA mediated transformation
SPWS13_RS11605	COG0242	peptide deformylase activity
SPWS13_RS11615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPWS13_RS11615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPWS13_RS11635	COG0640	Transcriptional regulator
SPWS13_RS11640	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
SPWS13_RS11650	COG1739	Uncharacterized protein family UPF0029
SPWS13_RS11665	COG0183	Belongs to the thiolase family
SPWS13_RS11680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SPWS13_RS11685	COG2818	Glycosylase
SPWS13_RS11690	COG0752	glycyl-tRNA synthetase alpha subunit
SPWS13_RS11700	COG1639	'signal transduction protein
SPWS13_RS11755	COG5002	protein histidine kinase activity
SPWS13_RS11760	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS11765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS11770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPWS13_RS11775	COG3104	oligopeptide transport
SPWS13_RS11780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SPWS13_RS11795	COG1192	Involved in chromosome partitioning
SPWS13_RS11800	COG1475	DNA binding
SPWS13_RS11855	COG4774	siderophore transport
SPWS13_RS11860	COG1349	DNA-binding transcription factor activity
SPWS13_RS11865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPWS13_RS11920	COG2861	carbohydrate metabolic process
SPWS13_RS11930	COG4942	peptidase
SPWS13_RS11935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SPWS13_RS11940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPWS13_RS11955	COG2081	HI0933 family
SPWS13_RS11965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPWS13_RS11970	COG0569	domain protein
SPWS13_RS11975	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS11980	COG2205	protein histidine kinase activity
SPWS13_RS11995	COG0791	NLP P60 protein
SPWS13_RS12000	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPWS13_RS12010	COG1668	transmembrane transport
SPWS13_RS12015	COG4555	ABC transporter
SPWS13_RS12025	COG2188	Transcriptional regulator
SPWS13_RS12030	COG1131	(ABC) transporter
SPWS13_RS12040	COG1022	Amp-dependent synthetase and ligase
SPWS13_RS12130	COG2188	Transcriptional regulator
SPWS13_RS12140	COG2986	histidine ammonia-lyase
SPWS13_RS12145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPWS13_RS12150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPWS13_RS12160	COG3344	reverse transcriptase
SPWS13_RS12175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPWS13_RS12190	COG0339	signal peptide processing
SPWS13_RS12205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS12210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPWS13_RS12225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SPWS13_RS12235	COG1196	nuclear chromosome segregation
SPWS13_RS12235	COG0741	lytic transglycosylase activity
SPWS13_RS12235	COG0739	heme binding
SPWS13_RS12240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SPWS13_RS12280	COG0346	lactoylglutathione lyase activity
SPWS13_RS12295	COG4232	protein-disulfide reductase activity
SPWS13_RS12315	COG0668	transmembrane transport
SPWS13_RS12360	COG1580	Controls the rotational direction of flagella during chemotaxis
SPWS13_RS12375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPWS13_RS12380	COG0303	'Molybdopterin
SPWS13_RS12385	COG1528	Iron-storage protein
SPWS13_RS12390	COG5001	Diguanylate cyclase
SPWS13_RS12390	COG3300	MHYT domain
SPWS13_RS12400	COG1770	oligopeptidase
SPWS13_RS12450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPWS13_RS12465	COG1301	dicarboxylic acid transport
SPWS13_RS12485	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPWS13_RS12505	COG3005	denitrification pathway
SPWS13_RS12515	COG0742	ribosomal rna small subunit methyltransferase
SPWS13_RS12520	COG0552	protein localization to endoplasmic reticulum
SPWS13_RS12525	COG2884	Cell division ATP-binding protein ftsE
SPWS13_RS12530	COG2177	Part of the ABC transporter FtsEX involved in
SPWS13_RS12545	COG3539	Fimbrial protein
SPWS13_RS12550	COG3121	Chaperone
SPWS13_RS12580	COG2203	Gaf domain
SPWS13_RS12580	COG5001	Diguanylate cyclase
SPWS13_RS12580	COG3706	GGDEF domain
SPWS13_RS12580	COG4251	negative regulation of phosphorylation
SPWS13_RS12585	COG0318	PFAM AMP-dependent synthetase and ligase
SPWS13_RS12590	COG1441	menaquinone biosynthetic process
SPWS13_RS12620	COG0437	4 iron, 4 sulfur cluster binding
SPWS13_RS12625	COG3301	Polysulphide reductase, NrfD
SPWS13_RS12630	COG1522	sequence-specific DNA binding
SPWS13_RS12675	COG2814	Major facilitator Superfamily
SPWS13_RS12710	COG0437	4 iron, 4 sulfur cluster binding
SPWS13_RS12715	COG3383	formate dehydrogenase (NAD+) activity
SPWS13_RS12715	COG0243	molybdopterin cofactor binding
SPWS13_RS12730	COG0437	4 iron, 4 sulfur cluster binding
SPWS13_RS12735	COG0243	molybdopterin cofactor binding
SPWS13_RS12735	COG3383	formate dehydrogenase (NAD+) activity
SPWS13_RS12765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SPWS13_RS12810	COG4771	TonB-dependent receptor
SPWS13_RS12815	COG0583	DNA-binding transcription factor activity
SPWS13_RS12830	COG0697	spore germination
SPWS13_RS12835	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SPWS13_RS12855	COG0823	Involved in the tonB-independent uptake of proteins
SPWS13_RS12855	COG1506	peptidase
SPWS13_RS12865	COG0612	Peptidase, M16
SPWS13_RS12870	COG1473	amidohydrolase
SPWS13_RS12900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPWS13_RS12905	COG3031	protein transport across the cell outer membrane
SPWS13_RS12915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPWS13_RS12920	COG1459	type II secretion system
SPWS13_RS12925	COG2165	general secretion pathway protein
SPWS13_RS12935	COG2165	general secretion pathway protein
SPWS13_RS12940	COG4795	General secretion pathway protein
SPWS13_RS12945	COG3156	type II secretion system protein K
SPWS13_RS12965	COG1011	Hydrolase
SPWS13_RS13000	COG0494	nUDIX hydrolase
SPWS13_RS13005	COG1218	3'(2'),5'-bisphosphate nucleotidase
SPWS13_RS13020	COG2814	Major facilitator Superfamily
SPWS13_RS13095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPWS13_RS13110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPWS13_RS13115	COG0137	argininosuccinate synthase activity
SPWS13_RS13125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SPWS13_RS13170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
SPWS13_RS13185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPWS13_RS13200	COG0583	DNA-binding transcription factor activity
SPWS13_RS13205	COG0697	spore germination
SPWS13_RS13210	COG2823	Periplasmic or secreted lipoprotein
SPWS13_RS13325	COG1132	(ABC) transporter
SPWS13_RS13330	COG1132	(ABC) transporter
SPWS13_RS13345	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPWS13_RS13350	COG4605	iron ion homeostasis
SPWS13_RS13355	COG4604	ABC transporter, ATP-binding protein
SPWS13_RS13360	COG4607	ABC-type enterochelin transport system periplasmic component
SPWS13_RS13380	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SPWS13_RS13410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SPWS13_RS13425	COG1757	Na H antiporter
SPWS13_RS13430	COG0251	oxidation-reduction process
SPWS13_RS13445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPWS13_RS13455	COG2828	Protein conserved in bacteria
SPWS13_RS13465	COG0372	Belongs to the citrate synthase family
SPWS13_RS13470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SPWS13_RS13485	COG0204	Acyl-transferase
SPWS13_RS13490	COG0204	Acyl-transferase
SPWS13_RS13525	COG1022	Amp-dependent synthetase and ligase
SPWS13_RS13535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPWS13_RS13580	COG1061	Type III restriction enzyme res subunit
SPWS13_RS13585	COG0583	DNA-binding transcription factor activity
SPWS13_RS13590	COG1011	Hydrolase
SPWS13_RS13595	COG0322	excinuclease ABC activity
SPWS13_RS13610	COG0583	DNA-binding transcription factor activity
SPWS13_RS13615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPWS13_RS13635	COG0129	dihydroxy-acid dehydratase activity
SPWS13_RS13640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPWS13_RS13645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPWS13_RS13665	COG0671	phosphoesterase, PA-phosphatase related
SPWS13_RS13695	COG0210	DNA helicase
SPWS13_RS13740	COG1538	Outer membrane efflux protein
SPWS13_RS13770	COG2959	enzyme of heme biosynthesis
SPWS13_RS13775	COG1587	Uroporphyrinogen-III synthase
SPWS13_RS13800	COG0019	diaminopimelate decarboxylase activity
SPWS13_RS13820	COG1011	Hydrolase
SPWS13_RS13835	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
SPWS13_RS13860	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPWS13_RS13865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPWS13_RS13870	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPWS13_RS13880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SPWS13_RS13885	COG1684	flagellar biosynthetic protein fliR
SPWS13_RS13890	COG1987	bacterial-type flagellum assembly
SPWS13_RS13900	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SPWS13_RS13925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SPWS13_RS13960	COG1815	bacterial-type flagellum-dependent cell motility
SPWS13_RS13980	COG4787	bacterial-type flagellum-dependent cell motility
SPWS13_RS13985	COG4786	Flagellar basal body rod
SPWS13_RS13990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SPWS13_RS14000	COG3951	Flagellar rod assembly protein muramidase FlgJ
SPWS13_RS14000	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPWS13_RS14020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SPWS13_RS14025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SPWS13_RS14030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SPWS13_RS14050	COG1580	Controls the rotational direction of flagella during chemotaxis
SPWS13_RS14055	COG1191	sigma factor activity
SPWS13_RS14060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SPWS13_RS14065	COG1360	Flagellar Motor Protein
SPWS13_RS14080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
SPWS13_RS14085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPWS13_RS14110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPWS13_RS14120	COG0604	alcohol dehydrogenase
SPWS13_RS14125	COG0583	DNA-binding transcription factor activity
SPWS13_RS14130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SPWS13_RS14135	COG3118	belongs to the thioredoxin family
SPWS13_RS14160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SPWS13_RS14170	COG0237	dephospho-CoA kinase activity
SPWS13_RS14180	COG1459	type II secretion system
SPWS13_RS14185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPWS13_RS14210	COG2186	Transcriptional regulator
SPWS13_RS14215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SPWS13_RS14220	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPWS13_RS14225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPWS13_RS14235	COG1752	Esterase of the alpha-beta hydrolase superfamily
SPWS13_RS14250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPWS13_RS14280	COG0300	oxidoreductase activity
SPWS13_RS14290	COG0151	Belongs to the GarS family
SPWS13_RS14295	COG0138	bifunctional purine biosynthesis protein purh
SPWS13_RS14300	COG0789	Transcriptional regulator
SPWS13_RS14305	COG0701	Predicted permease
SPWS13_RS14335	COG0471	metal ion transport
SPWS13_RS14340	COG3118	belongs to the thioredoxin family
SPWS13_RS14365	COG3976	FMN-binding domain protein
SPWS13_RS14365	COG1053	succinate dehydrogenase
SPWS13_RS14380	COG2186	Transcriptional regulator
SPWS13_RS14395	COG2358	TRAP transporter, solute receptor (TAXI family
SPWS13_RS14405	COG0433	COG0433 Predicted ATPase
SPWS13_RS14435	COG0210	DNA helicase
SPWS13_RS14450	COG0628	permease
SPWS13_RS14465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPWS13_RS14480	COG0484	heat shock protein binding
SPWS13_RS14490	COG0545	Peptidyl-prolyl cis-trans isomerase
SPWS13_RS14515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SPWS13_RS14550	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS14600	COG1970	mechanosensitive ion channel activity
SPWS13_RS14605	COG2153	protein acetylation
SPWS13_RS14625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SPWS13_RS14650	COG0643	Histidine kinase
SPWS13_RS14650	COG0784	Response regulator, receiver
SPWS13_RS14650	COG2198	Histidine kinase
SPWS13_RS14675	COG0745	RESPONSE REGULATOR receiver
SPWS13_RS14700	COG2200	EAL domain
SPWS13_RS14715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPWS13_RS14725	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SPWS13_RS14755	COG0204	Acyl-transferase
SPWS13_RS14760	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
SPWS13_RS14765	COG3706	GGDEF domain
SPWS13_RS14770	COG2201	protein-glutamate methylesterase activity
SPWS13_RS14775	COG1024	Enoyl-CoA hydratase
SPWS13_RS14785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPWS13_RS14825	COG0840	transmembrane signaling receptor activity
SPWS13_RS14835	COG0584	glycerophosphoryl diester phosphodiesterase
SPWS13_RS14840	COG1511	domain protein
SPWS13_RS14840	COG3264	Mechanosensitive ion channel
SPWS13_RS14845	COG0697	spore germination
SPWS13_RS14855	COG1162	GTPase activity
SPWS13_RS14920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPWS13_RS14925	COG0330	HflC and HflK could
SPWS13_RS14930	COG0330	HflC and HflK could
SPWS13_RS14935	COG0723	plastoquinol--plastocyanin reductase activity
SPWS13_RS14940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SPWS13_RS14945	COG2857	Cytochrome c1
SPWS13_RS14950	COG0625	glutathione transferase activity
SPWS13_RS14955	COG2969	positive regulation of protein catabolic process
SPWS13_RS14975	COG0612	Peptidase, M16
SPWS13_RS14985	COG0456	acetyltransferase
SPWS13_RS15000	COG0741	lytic transglycosylase activity
SPWS13_RS15000	COG1388	LysM domain
SPWS13_RS15010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS15025	COG0604	alcohol dehydrogenase
SPWS13_RS15025	COG3321	synthase
SPWS13_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS15035	COG2017	converts alpha-aldose to the beta-anomer
SPWS13_RS15040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPWS13_RS15050	COG4232	protein-disulfide reductase activity
SPWS13_RS15055	COG1324	tolerance protein
SPWS13_RS15075	COG1335	isochorismatase
SPWS13_RS15080	COG0347	Belongs to the P(II) protein family
SPWS13_RS15085	COG0004	ammonium transporteR
SPWS13_RS15100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPWS13_RS15110	COG5265	(ABC) transporter
SPWS13_RS15125	COG0069	glutamate synthase activity
SPWS13_RS15140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPWS13_RS15170	COG0405	Gamma-glutamyltransferase
SPWS13_RS15175	COG2837	iron assimilation
SPWS13_RS15185	COG2910	NAD(P)H-binding
SPWS13_RS15210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPWS13_RS15220	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SPWS13_RS15230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPWS13_RS15315	COG1944	ATP diphosphatase activity
SPWS13_RS15365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPWS13_RS15375	COG0534	Mate efflux family protein
SPWS13_RS15415	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
SPWS13_RS15420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPWS13_RS15435	COG4206	TonB-dependent receptor
SPWS13_RS15455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPWS13_RS15460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS15470	COG1538	Outer membrane efflux protein
SPWS13_RS15500	COG1785	Belongs to the alkaline phosphatase family
SPWS13_RS15505	COG0189	ligase activity
SPWS13_RS15510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPWS13_RS15520	COG3091	SprT-like family
SPWS13_RS15535	COG0583	DNA-binding transcription factor activity
SPWS13_RS15555	COG3043	anaerobic respiration
SPWS13_RS15560	COG0348	domain, Protein
SPWS13_RS15565	COG0437	4 iron, 4 sulfur cluster binding
SPWS13_RS15570	COG0243	molybdopterin cofactor binding
SPWS13_RS15575	COG3062	negative regulation of establishment of protein localization
SPWS13_RS15585	COG0577	efflux transmembrane transporter activity
SPWS13_RS15590	COG1136	(ABC) transporter
SPWS13_RS15600	COG2205	protein histidine kinase activity
SPWS13_RS15600	COG0784	Response regulator, receiver
SPWS13_RS15600	COG5002	protein histidine kinase activity
SPWS13_RS15605	COG3437	response regulator, receiver
SPWS13_RS15610	COG0354	folic acid binding
SPWS13_RS15615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPWS13_RS15620	COG3647	Membrane
SPWS13_RS15655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPWS13_RS15665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPWS13_RS15680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPWS13_RS15690	COG3954	Phosphoribulokinase
SPWS13_RS15700	COG0429	hydrolase of the alpha beta-hydrolase fold
SPWS13_RS15725	COG0488	(ABC) transporter
SPWS13_RS15730	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
SPWS13_RS15735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPWS13_RS15740	COG0210	DNA helicase
SPWS13_RS15745	COG1741	Belongs to the pirin family
SPWS13_RS15750	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS15755	COG0840	transmembrane signaling receptor activity
SPWS13_RS15760	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS15775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SPWS13_RS15825	COG0306	phosphate transporter
SPWS13_RS15830	COG1392	Phosphate transport regulator
SPWS13_RS15835	COG3025	triphosphatase activity
SPWS13_RS15840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPWS13_RS15865	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPWS13_RS15885	COG5001	Diguanylate cyclase
SPWS13_RS15885	COG5002	protein histidine kinase activity
SPWS13_RS15885	COG3447	MASE1 domain protein
SPWS13_RS15905	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SPWS13_RS15910	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SPWS13_RS15915	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SPWS13_RS15925	COG2205	protein histidine kinase activity
SPWS13_RS15935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SPWS13_RS15945	COG1376	ErfK ybiS ycfS ynhG family protein
SPWS13_RS15950	COG3604	Transcriptional regulator
SPWS13_RS15965	COG1560	Kdo2-lipid A biosynthetic process
SPWS13_RS15970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPWS13_RS15970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SPWS13_RS15985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SPWS13_RS15990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SPWS13_RS16000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPWS13_RS16005	COG0175	sulfate reduction
SPWS13_RS16010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPWS13_RS16030	COG1764	response to oxidative stress
SPWS13_RS16035	COG1846	Transcriptional regulator
SPWS13_RS16060	COG3383	formate dehydrogenase (NAD+) activity
SPWS13_RS16080	COG1686	Belongs to the peptidase S11 family
SPWS13_RS16090	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
SPWS13_RS16105	COG2895	sulfate adenylyltransferase (ATP) activity
SPWS13_RS16110	COG3273	potassium ion transport
SPWS13_RS16110	COG0471	metal ion transport
SPWS13_RS16125	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
SPWS13_RS16140	COG0484	heat shock protein binding
SPWS13_RS16165	COG1126	abc transporter atp-binding protein
SPWS13_RS16170	COG0765	amino acid transport
SPWS13_RS16175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPWS13_RS16180	COG0583	DNA-binding transcription factor activity
SPWS13_RS16190	COG1346	cytolysis
SPWS13_RS16200	COG1966	Carbon starvation protein
SPWS13_RS16205	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SPWS13_RS16220	COG0306	phosphate transporter
SPWS13_RS16225	COG1801	Protein of unknown function DUF72
SPWS13_RS16255	COG0242	peptide deformylase activity
SPWS13_RS16270	COG0545	Peptidyl-prolyl cis-trans isomerase
SPWS13_RS16320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPWS13_RS16360	COG1136	(ABC) transporter
SPWS13_RS16365	COG0577	efflux transmembrane transporter activity
SPWS13_RS16370	COG0577	efflux transmembrane transporter activity
SPWS13_RS16370	COG1136	(ABC) transporter
SPWS13_RS16400	COG1309	transcriptional regulator
SPWS13_RS16430	COG2252	PERMEase
SPWS13_RS16435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPWS13_RS16440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPWS13_RS16450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPWS13_RS16515	COG1120	ATPase activity
SPWS13_RS16520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPWS13_RS16540	COG1492	cobalamin metabolic process
SPWS13_RS16545	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SPWS13_RS16555	COG4974	Belongs to the 'phage' integrase family
SPWS13_RS16580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPWS13_RS16585	COG1012	belongs to the aldehyde dehydrogenase family
SPWS13_RS16595	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS16605	COG0545	Peptidyl-prolyl cis-trans isomerase
SPWS13_RS16610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPWS13_RS16615	COG0505	Belongs to the CarA family
SPWS13_RS16620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPWS13_RS16625	COG0564	pseudouridine synthase activity
SPWS13_RS16640	COG2239	Acts as a magnesium transporter
SPWS13_RS16660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPWS13_RS16665	COG2354	Protein conserved in bacteria
SPWS13_RS16680	COG0653	protein targeting
SPWS13_RS16725	COG0783	Belongs to the Dps family
SPWS13_RS16745	COG0321	lipoyl(octanoyl) transferase activity
SPWS13_RS16755	COG1686	Belongs to the peptidase S11 family
SPWS13_RS16760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SPWS13_RS16765	COG2951	lytic endotransglycosylase activity
SPWS13_RS16785	COG0799	negative regulation of ribosome biogenesis
SPWS13_RS16800	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
SPWS13_RS16820	COG2165	general secretion pathway protein
SPWS13_RS16825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPWS13_RS16840	COG1702	phosphate starvation-inducible protein PhoH
SPWS13_RS16860	COG0012	GTP binding
SPWS13_RS16930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPWS13_RS16935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPWS13_RS16940	COG1534	Rna-binding protein
SPWS13_RS16955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPWS13_RS16960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPWS13_RS16990	COG0195	Participates in both transcription termination and antitermination
SPWS13_RS17045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPWS13_RS17050	COG3248	Nucleoside-binding outer membrane protein
SPWS13_RS17080	COG0560	Phosphoserine phosphatase
SPWS13_RS17105	COG2252	PERMEase
SPWS13_RS17110	COG0517	IMP dehydrogenase activity
SPWS13_RS17110	COG0617	tRNA 3'-terminal CCA addition
SPWS13_RS17110	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPWS13_RS17155	COG0826	peptidase U32
SPWS13_RS17160	COG0826	peptidase U32
SPWS13_RS17165	COG3154	lipid carrier protein
SPWS13_RS17170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SPWS13_RS17175	COG0826	peptidase U32
SPWS13_RS17185	COG5001	Diguanylate cyclase
SPWS13_RS17190	COG0824	Thioesterase
SPWS13_RS17195	COG0784	Response regulator, receiver
SPWS13_RS17195	COG0835	chemotaxis
SPWS13_RS17200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPWS13_RS17220	COG1309	transcriptional regulator
SPWS13_RS17225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS17245	COG2814	Major facilitator Superfamily
SPWS13_RS17255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS17275	COG0583	DNA-binding transcription factor activity
SPWS13_RS17280	COG0488	(ABC) transporter
SPWS13_RS17285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPWS13_RS17295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPWS13_RS17295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPWS13_RS17320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SPWS13_RS17325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPWS13_RS17330	COG0497	DNA recombination
SPWS13_RS17340	COG0583	DNA-binding transcription factor activity
SPWS13_RS17360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPWS13_RS17400	COG3956	TIGRFAM MazG family protein
SPWS13_RS17420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPWS13_RS17430	COG0585	pseudouridine synthase activity
SPWS13_RS17445	COG4942	peptidase
SPWS13_RS17445	COG1388	LysM domain
SPWS13_RS17450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPWS13_RS17530	COG2927	DNA polymerase III (CHI subunit)
SPWS13_RS17535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SPWS13_RS17550	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
SPWS13_RS17570	COG0083	homoserine kinase activity
SPWS13_RS17575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPWS13_RS17585	COG4946	Tricorn protease homolog
SPWS13_RS17585	COG0793	Belongs to the peptidase S41A family
SPWS13_RS17620	COG0217	transcriptional regulatory protein
SPWS13_RS17625	COG0840	transmembrane signaling receptor activity
SPWS13_RS17640	COG1902	pentaerythritol trinitrate reductase activity
SPWS13_RS17645	COG1067	ATP-dependent peptidase activity
SPWS13_RS17650	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS17670	COG0415	Belongs to the DNA photolyase family
SPWS13_RS17680	COG0300	oxidoreductase activity
SPWS13_RS17695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SPWS13_RS17745	COG3038	cytochrome b561
SPWS13_RS17760	COG1194	a g-specific adenine glycosylase
SPWS13_RS17765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPWS13_RS17770	COG3171	Protein conserved in bacteria
SPWS13_RS17785	COG0583	DNA-binding transcription factor activity
SPWS13_RS17795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPWS13_RS17800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPWS13_RS17810	COG1872	DUF167
SPWS13_RS17815	COG0762	integral membrane protein
SPWS13_RS17820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPWS13_RS17845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPWS13_RS17850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPWS13_RS17860	COG0023	Translation Initiation Factor
SPWS13_RS17875	COG2860	membrane
SPWS13_RS17880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPWS13_RS17885	COG0668	transmembrane transport
SPWS13_RS17895	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
SPWS13_RS17900	COG3228	Belongs to the MtfA family
SPWS13_RS17905	COG2203	Gaf domain
SPWS13_RS17905	COG3706	GGDEF domain
SPWS13_RS17905	COG5001	Diguanylate cyclase
SPWS13_RS17905	COG4251	negative regulation of phosphorylation
SPWS13_RS17920	COG3530	Putative quorum-sensing-regulated virulence factor
SPWS13_RS17940	COG1741	Belongs to the pirin family
SPWS13_RS17945	COG2259	Doxx family
SPWS13_RS17950	COG0583	DNA-binding transcription factor activity
SPWS13_RS17960	COG1253	flavin adenine dinucleotide binding
SPWS13_RS17965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPWS13_RS17975	COG1426	Protein conserved in bacteria
SPWS13_RS17990	COG2976	Protein conserved in bacteria
SPWS13_RS17995	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPWS13_RS18000	COG1160	GTP binding
SPWS13_RS18025	COG0590	tRNA wobble adenosine to inosine editing
SPWS13_RS18045	COG1294	oxidase, subunit
SPWS13_RS18050	COG4890	Cyd operon protein YbgT
SPWS13_RS18100	COG1086	Polysaccharide biosynthesis protein
SPWS13_RS18105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPWS13_RS18120	COG2089	acid synthase
SPWS13_RS18135	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS18155	COG3475	LICD family
SPWS13_RS18225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SPWS13_RS18230	COG1815	bacterial-type flagellum-dependent cell motility
SPWS13_RS18250	COG4786	Flagellar basal body rod
SPWS13_RS18255	COG4786	Flagellar basal body rod
SPWS13_RS18265	COG1706	bacterial-type flagellum-dependent cell motility
SPWS13_RS18270	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPWS13_RS18270	COG3951	Flagellar rod assembly protein muramidase FlgJ
SPWS13_RS18280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SPWS13_RS18290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SPWS13_RS18310	COG1516	flagellar protein fliS
SPWS13_RS18330	COG1677	Flagellar hook-basal body complex protein FliE
SPWS13_RS18340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SPWS13_RS18390	COG1987	bacterial-type flagellum assembly
SPWS13_RS18430	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SPWS13_RS18435	COG0643	Histidine kinase
SPWS13_RS18435	COG2198	Histidine kinase
SPWS13_RS18435	COG0784	Response regulator, receiver
SPWS13_RS18450	COG1192	Involved in chromosome partitioning
SPWS13_RS18460	COG0835	chemotaxis
SPWS13_RS18470	COG2257	FlhB HrpN YscU SpaS Family
SPWS13_RS18480	COG2853	Lipoprotein
SPWS13_RS18490	COG3104	oligopeptide transport
SPWS13_RS18555	COG1215	transferase activity, transferring glycosyl groups
SPWS13_RS18555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPWS13_RS18595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPWS13_RS18600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPWS13_RS18650	COG0442	prolyl-tRNA aminoacylation
SPWS13_RS18655	COG0110	maltose O-acetyltransferase activity
SPWS13_RS18660	COG1720	tRNA m6t6A37 methyltransferase activity
SPWS13_RS18670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPWS13_RS18675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SPWS13_RS18695	COG1757	Na H antiporter
SPWS13_RS18700	COG0339	signal peptide processing
SPWS13_RS18710	COG1435	thymidine kinase activity
SPWS13_RS18740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SPWS13_RS18825	COG1132	(ABC) transporter
SPWS13_RS18835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPWS13_RS18840	COG0513	Belongs to the DEAD box helicase family
SPWS13_RS18850	COG0784	Response regulator, receiver
SPWS13_RS18850	COG0835	chemotaxis
SPWS13_RS18875	COG0564	pseudouridine synthase activity
SPWS13_RS18900	COG1862	Preprotein translocase
SPWS13_RS18905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPWS13_RS18910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPWS13_RS18920	COG1648	precorrin-2 dehydrogenase activity
SPWS13_RS18920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPWS13_RS18925	COG4681	YaeQ
SPWS13_RS18935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPWS13_RS18950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPWS13_RS18965	COG2067	long-chain fatty acid transport protein
SPWS13_RS18990	COG2304	oxidoreductase activity
SPWS13_RS19010	COG0714	Associated with various cellular activities
SPWS13_RS19020	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPWS13_RS19020	COG1024	Enoyl-CoA hydratase
SPWS13_RS19055	COG2062	phosphohistidine phosphatase, SixA
SPWS13_RS19065	COG2890	protein-(glutamine-N5) methyltransferase activity
SPWS13_RS19075	COG2211	Major facilitator Superfamily
SPWS13_RS19100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPWS13_RS19105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPWS13_RS19110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPWS13_RS19120	COG0101	tRNA pseudouridine synthase activity
SPWS13_RS19125	COG0285	dihydrofolate synthase activity
SPWS13_RS19135	COG1286	toxin biosynthetic process
SPWS13_RS19140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPWS13_RS19155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SPWS13_RS19160	COG3604	Transcriptional regulator
SPWS13_RS19170	COG2986	histidine ammonia-lyase
SPWS13_RS19190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SPWS13_RS19215	COG0840	transmembrane signaling receptor activity
SPWS13_RS19235	COG0708	Exodeoxyribonuclease III
SPWS13_RS19240	COG2350	Protein conserved in bacteria
SPWS13_RS19270	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SPWS13_RS19290	COG0133	tryptophan synthase activity
SPWS13_RS19295	COG0134	indole-3-glycerol-phosphate synthase activity
SPWS13_RS19295	COG0135	phosphoribosylanthranilate isomerase activity
SPWS13_RS19305	COG0512	Glutamine amidotransferase of anthranilate synthase
SPWS13_RS19310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPWS13_RS19320	COG0009	L-threonylcarbamoyladenylate synthase
SPWS13_RS19325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPWS13_RS19330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPWS13_RS19345	COG1028	Short-chain dehydrogenase reductase Sdr
SPWS13_RS19350	COG2267	carboxylic ester hydrolase activity
SPWS13_RS19370	COG4181	ATPase activity
SPWS13_RS19375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SPWS13_RS19380	COG0786	glutamate:sodium symporter activity
SPWS13_RS19385	COG1090	epimerase
SPWS13_RS19390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPWS13_RS19395	COG0628	permease
SPWS13_RS19400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPWS13_RS19415	COG0280	phosphate acetyltransferase
SPWS13_RS19415	COG0857	belongs to the CobB CobQ family
SPWS13_RS19425	COG3092	negative regulation of chromosome organization
SPWS13_RS19430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPWS13_RS19435	COG1882	Formate acetyltransferase
SPWS13_RS19445	COG2116	formate transmembrane transporter activity
SPWS13_RS19450	COG0583	DNA-binding transcription factor activity
SPWS13_RS19455	COG1288	antiporter activity
SPWS13_RS19460	COG4206	TonB-dependent receptor
SPWS13_RS19470	COG2813	Specifically methylates the guanine in position
SPWS13_RS19475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPWS13_RS19480	COG1714	RDD family
SPWS13_RS19495	COG1196	nuclear chromosome segregation
SPWS13_RS19525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SPWS13_RS19535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPWS13_RS19540	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SPWS13_RS19560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPWS13_RS19595	COG1061	Type III restriction enzyme res subunit
SPWS13_RS19600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPWS13_RS19605	COG5002	protein histidine kinase activity
SPWS13_RS19630	COG2226	methyltransferase
SPWS13_RS19640	COG4771	TonB-dependent receptor
SPWS13_RS19665	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SPWS13_RS19670	COG3340	Belongs to the peptidase S51 family
SPWS13_RS19680	COG1053	succinate dehydrogenase
SPWS13_RS19685	COG2197	response regulator
SPWS13_RS19710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPWS13_RS19730	COG3806	Anti-sigma factor
SPWS13_RS19735	COG1595	DNA-templated transcription, initiation
SPWS13_RS19745	COG2226	methyltransferase
SPWS13_RS19750	COG0835	chemotaxis
SPWS13_RS19750	COG0784	Response regulator, receiver
SPWS13_RS19765	COG2951	lytic endotransglycosylase activity