locus-tag	class	description
C1P65_RS00010	COG1988	membrane-bound metal-dependent
C1P65_RS00015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1P65_RS00025	COG3001	Fructosamine kinase
C1P65_RS00035	COG1105	Belongs to the carbohydrate kinase PfkB family
C1P65_RS00090	COG0386	Belongs to the glutathione peroxidase family
C1P65_RS00100	COG0791	NLP P60 protein
C1P65_RS00110	COG2200	EAL domain
C1P65_RS00120	COG4256	Hemin uptake protein
C1P65_RS00125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1P65_RS00140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1P65_RS00140	COG0574	Belongs to the PEP-utilizing enzyme family
C1P65_RS00150	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C1P65_RS00155	COG0644	oxidoreductase
C1P65_RS00180	COG1917	Cupin 2, conserved barrel domain protein
C1P65_RS00180	COG2207	Transcriptional regulator
C1P65_RS00190	COG1960	acyl-CoA dehydrogenase activity
C1P65_RS00215	COG2267	carboxylic ester hydrolase activity
C1P65_RS00240	COG1643	Atp-dependent helicase
C1P65_RS00300	COG3038	cytochrome b561
C1P65_RS00345	COG0583	DNA-binding transcription factor activity
C1P65_RS00350	COG5383	Protein conserved in bacteria
C1P65_RS00365	COG2841	Protein conserved in bacteria
C1P65_RS00370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1P65_RS00385	COG1275	C4-dicarboxylate transporter malic acid transport protein
C1P65_RS00390	COG0500	methyltransferase
C1P65_RS00415	COG1396	sequence-specific DNA binding
C1P65_RS00445	COG1598	PFAM Uncharacterised protein family UPF0150
C1P65_RS00450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1P65_RS00455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1P65_RS00460	COG3842	ATPase activity
C1P65_RS00505	COG3238	Protein conserved in bacteria
C1P65_RS00510	COG1247	-acetyltransferase
C1P65_RS00515	COG2130	NADP-dependent
C1P65_RS00535	COG1760	l-serine dehydratase
C1P65_RS00545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1P65_RS00565	COG0251	oxidation-reduction process
C1P65_RS00570	COG1199	ATP-dependent helicase activity
C1P65_RS00575	COG1214	PFAM Peptidase M22, glycoprotease
C1P65_RS00580	COG3065	identical protein binding
C1P65_RS00590	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1P65_RS00595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1P65_RS00600	COG4638	Rieske (2fe-2S)
C1P65_RS00620	COG0473	3-isopropylmalate dehydrogenase activity
C1P65_RS00625	COG0583	DNA-binding transcription factor activity
C1P65_RS00640	COG3615	Tellurite resistance protein tehB
C1P65_RS00650	COG2261	transglycosylase associated protein
C1P65_RS00675	COG2203	Gaf domain
C1P65_RS00675	COG2199	diguanylate cyclase activity
C1P65_RS00680	COG3042	response to heat
C1P65_RS00685	COG3189	MarR family transcriptional regulator
C1P65_RS00690	COG2807	transmembrane transport
C1P65_RS00695	COG2207	Transcriptional regulator
C1P65_RS00710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1P65_RS00715	COG2199	diguanylate cyclase activity
C1P65_RS00755	COG0628	permease
C1P65_RS00760	COG0277	FAD linked oxidase domain protein
C1P65_RS00760	COG0247	lactate metabolic process
C1P65_RS00765	COG2050	protein possibly involved in aromatic compounds catabolism
C1P65_RS00850	COG2207	Transcriptional regulator
C1P65_RS00860	COG0243	molybdopterin cofactor binding
C1P65_RS00880	COG0384	phenazine biosynthesis protein PhzF
C1P65_RS00885	COG2181	nitrate reductase activity
C1P65_RS00890	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C1P65_RS00895	COG1140	nitrate reductase beta subunit
C1P65_RS00915	COG4168	peptide transport system, permease
C1P65_RS00920	COG4166	transmembrane transport
C1P65_RS00945	COG0583	DNA-binding transcription factor activity
C1P65_RS00950	COG1012	belongs to the aldehyde dehydrogenase family
C1P65_RS00965	COG2199	diguanylate cyclase activity
C1P65_RS01005	COG3188	usher protein
C1P65_RS01025	COG0076	glutamate decarboxylase activity
C1P65_RS01030	COG0531	amino acid
C1P65_RS01035	COG1649	PFAM Uncharacterised BCR, COG1649
C1P65_RS01050	COG4608	Belongs to the ABC transporter superfamily
C1P65_RS01055	COG1764	response to oxidative stress
C1P65_RS01065	COG3093	addiction module antidote protein HigA
C1P65_RS01070	COG2864	formate dehydrogenase
C1P65_RS01075	COG0437	4 iron, 4 sulfur cluster binding
C1P65_RS01125	COG1846	Transcriptional regulator
C1P65_RS01130	COG4977	sequence-specific DNA binding
C1P65_RS01140	COG0697	spore germination
C1P65_RS01145	COG2814	Major facilitator Superfamily
C1P65_RS01160	COG3706	GGDEF domain
C1P65_RS01165	COG3111	PFAM Bacterial OB fold (BOF) protein
C1P65_RS01170	COG1546	Belongs to the CinA family
C1P65_RS01175	COG0339	signal peptide processing
C1P65_RS01180	COG4221	oxidoreductase activity
C1P65_RS01185	COG1802	Transcriptional regulator
C1P65_RS01200	COG0477	Major facilitator Superfamily
C1P65_RS01275	COG0437	4 iron, 4 sulfur cluster binding
C1P65_RS01280	COG3302	dmso reductase anchor subunit
C1P65_RS01295	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1P65_RS01300	COG1940	carbohydrate kinase activity
C1P65_RS01305	COG0583	DNA-binding transcription factor activity
C1P65_RS01335	COG3591	Belongs to the peptidase S1B family
C1P65_RS01355	COG0628	permease
C1P65_RS01360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1P65_RS01365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1P65_RS01375	COG0531	amino acid
C1P65_RS01385	COG3136	membrane protein required for alginate biosynthesis
C1P65_RS01410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1P65_RS01420	COG0322	excinuclease ABC activity
C1P65_RS01440	COG3678	ATP-independent chaperone mediated protein folding
C1P65_RS01480	COG0708	Exodeoxyribonuclease III
C1P65_RS01490	COG0398	Pfam SNARE associated Golgi protein
C1P65_RS01495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1P65_RS01510	COG4136	ATPase activity
C1P65_RS01515	COG2897	thiosulfate sulfurtransferase activity
C1P65_RS01520	COG2897	thiosulfate sulfurtransferase activity
C1P65_RS01530	COG0494	nUDIX hydrolase
C1P65_RS01540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1P65_RS01560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1P65_RS01565	COG0709	Synthesizes selenophosphate from selenide and ATP
C1P65_RS01570	COG0778	Nitroreductase
C1P65_RS01575	COG0616	signal peptide processing
C1P65_RS01580	COG0252	asparaginase activity
C1P65_RS01585	COG1335	isochorismatase
C1P65_RS01630	COG1349	DNA-binding transcription factor activity
C1P65_RS01640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1P65_RS01655	COG2271	Major facilitator Superfamily
C1P65_RS01675	COG3139	Protein of unknown function (DUF1315)
C1P65_RS01685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1P65_RS01690	COG0676	glucose-6-phosphate 1-epimerase activity
C1P65_RS01695	COG0656	L-ascorbic acid biosynthetic process
C1P65_RS01700	COG3713	MltA-interacting MipA family protein
C1P65_RS01740	COG2271	Major facilitator Superfamily
C1P65_RS01790	COG2911	Protein conserved in bacteria
C1P65_RS01795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1P65_RS01805	COG3042	response to heat
C1P65_RS01810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1P65_RS01810	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1P65_RS01810	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1P65_RS01810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1P65_RS01825	COG0589	response to stress
C1P65_RS01835	COG1121	(ABC) transporter
C1P65_RS01840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1P65_RS01845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1P65_RS01950	COG0484	heat shock protein binding
C1P65_RS01955	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C1P65_RS01960	COG1403	HNH endonuclease
C1P65_RS02035	COG3706	GGDEF domain
C1P65_RS02050	COG2840	Smr protein MutS2
C1P65_RS02070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1P65_RS02090	COG0589	response to stress
C1P65_RS02110	COG0668	transmembrane transport
C1P65_RS02115	COG4166	transmembrane transport
C1P65_RS02120	COG0583	DNA-binding transcription factor activity
C1P65_RS02130	COG2866	Carboxypeptidase
C1P65_RS02135	COG4948	Mandelate Racemase Muconate Lactonizing
C1P65_RS02140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C1P65_RS02145	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C1P65_RS02155	COG3106	COG3106 Predicted ATPase
C1P65_RS02160	COG1609	Transcriptional regulator
C1P65_RS02175	COG3772	lysozyme
C1P65_RS02260	COG4171	peptide transport system, permease
C1P65_RS02265	COG4172	Belongs to the ABC transporter superfamily
C1P65_RS02270	COG4172	Belongs to the ABC transporter superfamily
C1P65_RS02275	COG3547	Transposase (IS116 IS110 IS902 family)
C1P65_RS02280	COG2814	Major facilitator Superfamily
C1P65_RS02310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1P65_RS02340	COG1349	DNA-binding transcription factor activity
C1P65_RS02345	COG0023	Translation Initiation Factor
C1P65_RS02355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1P65_RS02360	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C1P65_RS02365	COG0671	phosphoesterase, PA-phosphatase related
C1P65_RS02425	COG0583	DNA-binding transcription factor activity
C1P65_RS02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1P65_RS02440	COG0616	signal peptide processing
C1P65_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS02450	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C1P65_RS02455	COG1187	pseudouridine synthase activity
C1P65_RS02460	COG4907	membrane protein (DUF2207)
C1P65_RS02470	COG0009	L-threonylcarbamoyladenylate synthase
C1P65_RS02475	COG0613	PHP domain protein
C1P65_RS02485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1P65_RS02490	COG0512	Glutamine amidotransferase of anthranilate synthase
C1P65_RS02490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1P65_RS02540	COG3685	Protein conserved in bacteria
C1P65_RS02545	COG3047	cAMP biosynthetic process
C1P65_RS02565	COG1607	acyl-coa hydrolase
C1P65_RS02570	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1P65_RS02605	COG2350	Protein conserved in bacteria
C1P65_RS02610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1P65_RS02630	COG4608	Belongs to the ABC transporter superfamily
C1P65_RS02635	COG0444	Belongs to the ABC transporter superfamily
C1P65_RS02640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1P65_RS02645	COG0601	transmembrane transport
C1P65_RS02650	COG4166	transmembrane transport
C1P65_RS02675	COG1012	belongs to the aldehyde dehydrogenase family
C1P65_RS02675	COG1454	alcohol dehydrogenase
C1P65_RS02715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1P65_RS02720	COG0745	RESPONSE REGULATOR receiver
C1P65_RS02735	COG0788	formyltetrahydrofolate deformylase activity
C1P65_RS02750	COG2181	nitrate reductase activity
C1P65_RS02755	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C1P65_RS02760	COG1140	nitrate reductase beta subunit
C1P65_RS02765	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1P65_RS02770	COG2223	nitrite transmembrane transporter activity
C1P65_RS02775	COG3850	Histidine kinase
C1P65_RS02780	COG2197	response regulator
C1P65_RS02800	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1P65_RS02805	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1P65_RS02810	COG4572	Cation transport regulator
C1P65_RS02820	COG0387	Pfam Sodium calcium exchanger
C1P65_RS02845	COG2912	Transglutaminase-like superfamily
C1P65_RS02850	COG3094	Invasion gene expression up-regulator, SirB
C1P65_RS02880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1P65_RS02885	COG0659	secondary active sulfate transmembrane transporter activity
C1P65_RS02900	COG0012	GTP binding
C1P65_RS02955	COG1120	ATPase activity
C1P65_RS02960	COG0500	methyltransferase
C1P65_RS02965	COG0157	Belongs to the NadC ModD family
C1P65_RS02980	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C1P65_RS03035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1P65_RS03045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1P65_RS03080	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1P65_RS03110	COG2894	cell division
C1P65_RS03170	COG0582	viral genome integration into host DNA
C1P65_RS03180	COG1276	copper resistance
C1P65_RS03185	COG2372	response to copper ion
C1P65_RS03195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1P65_RS03200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1P65_RS03205	COG1770	oligopeptidase
C1P65_RS03210	COG2979	Protein of unknown function (DUF533)
C1P65_RS03220	COG3141	response to X-ray
C1P65_RS03230	COG0800	Aldolase
C1P65_RS03235	COG0129	dihydroxy-acid dehydratase activity
C1P65_RS03240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1P65_RS03250	COG0469	pyruvate kinase activity
C1P65_RS03255	COG1560	Kdo2-lipid A biosynthetic process
C1P65_RS03265	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1P65_RS03275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1P65_RS03310	COG0494	nUDIX hydrolase
C1P65_RS03320	COG1335	isochorismatase
C1P65_RS03325	COG3547	Transposase (IS116 IS110 IS902 family)
C1P65_RS03380	COG1801	Protein of unknown function DUF72
C1P65_RS03385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C1P65_RS03400	COG0243	molybdopterin cofactor binding
C1P65_RS03445	COG3102	Protein conserved in bacteria
C1P65_RS03490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1P65_RS03505	COG0589	response to stress
C1P65_RS03535	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1P65_RS03545	COG1879	ABC-type sugar transport system periplasmic component
C1P65_RS03565	COG1528	Iron-storage protein
C1P65_RS03580	COG1528	Iron-storage protein
C1P65_RS03590	COG0814	amino acid
C1P65_RS03595	COG3012	SEC-C Motif Domain Protein
C1P65_RS03595	COG3318	Belongs to the UPF0149 family
C1P65_RS03625	COG2197	response regulator
C1P65_RS03655	COG1126	abc transporter atp-binding protein
C1P65_RS03660	COG0765	amino acid transport
C1P65_RS03670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1P65_RS03680	COG1191	sigma factor activity
C1P65_RS03700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1P65_RS03705	COG1516	flagellar protein fliS
C1P65_RS03715	COG0366	Alpha amylase catalytic
C1P65_RS03725	COG2391	methyltransferase activity
C1P65_RS03730	COG0425	Belongs to the sulfur carrier protein TusA family
C1P65_RS03735	COG2135	peptidase activity
C1P65_RS03860	COG0500	methyltransferase
C1P65_RS03910	COG5475	Uncharacterized small protein (DUF2158)
C1P65_RS03915	COG2354	Protein conserved in bacteria
C1P65_RS03920	COG0697	spore germination
C1P65_RS03925	COG3727	T/G mismatch-specific endonuclease activity
C1P65_RS03930	COG0270	DNA (cytosine-5-)-methyltransferase activity
C1P65_RS03975	COG2205	protein histidine kinase activity
C1P65_RS04005	COG0745	RESPONSE REGULATOR receiver
C1P65_RS04035	COG3443	Belongs to the bacterial solute-binding protein 9 family
C1P65_RS04080	COG2819	hydrolase of the alpha beta superfamily
C1P65_RS04145	COG2003	Belongs to the UPF0758 family
C1P65_RS04200	COG3381	protein complex oligomerization
C1P65_RS04220	COG1462	curli production assembly transport component CsgG
C1P65_RS04265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1P65_RS04275	COG1309	transcriptional regulator
C1P65_RS04310	COG2233	PERMEase
C1P65_RS04315	COG3729	General stress protein
C1P65_RS04380	COG0745	RESPONSE REGULATOR receiver
C1P65_RS04385	COG1879	ABC-type sugar transport system periplasmic component
C1P65_RS04410	COG1278	Cold shock
C1P65_RS04430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1P65_RS04435	COG1596	polysaccharide export
C1P65_RS04440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1P65_RS04445	COG3206	protein involved in exopolysaccharide biosynthesis
C1P65_RS04445	COG0489	protein tyrosine kinase activity
C1P65_RS04460	COG1294	oxidase, subunit
C1P65_RS04465	COG1271	oxidase subunit
C1P65_RS04475	COG1999	signal sequence binding
C1P65_RS04480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1P65_RS04485	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C1P65_RS04495	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C1P65_RS04505	COG0670	Belongs to the BI1 family
C1P65_RS04515	COG1254	Belongs to the acylphosphatase family
C1P65_RS04530	COG1832	CoA-binding protein
C1P65_RS04545	COG0210	DNA helicase
C1P65_RS04550	COG3304	Inner membrane component domain
C1P65_RS04555	COG1289	transmembrane transporter activity
C1P65_RS04560	COG3070	regulator of competence-specific genes
C1P65_RS04590	COG1067	ATP-dependent peptidase activity
C1P65_RS04600	COG3130	regulation of translation
C1P65_RS04605	COG3009	Protein conserved in bacteria
C1P65_RS04610	COG3008	intermembrane lipid transfer
C1P65_RS04610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1P65_RS04615	COG2995	paraquat-inducible protein a
C1P65_RS04620	COG0488	(ABC) transporter
C1P65_RS04630	COG3217	Mosc domain protein beta barrel domain protein
C1P65_RS04630	COG0633	Ferredoxin
C1P65_RS04645	COG3121	Chaperone
C1P65_RS04650	COG3539	Fimbrial protein
C1P65_RS04655	COG3539	Fimbrial protein
C1P65_RS04690	COG2814	Major facilitator Superfamily
C1P65_RS04705	COG0246	Mannitol dehydrogenase
C1P65_RS04710	COG0523	cobalamin synthesis protein
C1P65_RS04715	COG0671	phosphoesterase, PA-phosphatase related
C1P65_RS04720	COG0791	NLP P60 protein
C1P65_RS04725	COG2200	EAL domain
C1P65_RS04730	COG4166	transmembrane transport
C1P65_RS04735	COG4174	ABC transporter (Permease)
C1P65_RS04740	COG4239	(ABC) transporter, permease
C1P65_RS04745	COG4172	Belongs to the ABC transporter superfamily
C1P65_RS04755	COG2814	Major facilitator Superfamily
C1P65_RS04760	COG1187	pseudouridine synthase activity
C1P65_RS04765	COG1061	Type III restriction enzyme res subunit
C1P65_RS04785	COG3083	sulfuric ester hydrolase activity
C1P65_RS04820	COG2197	response regulator
C1P65_RS04825	COG4235	cytochrome complex assembly
C1P65_RS04825	COG3088	subunit of a heme lyase
C1P65_RS04830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1P65_RS04835	COG1138	Cytochrome C-type biogenesis protein
C1P65_RS04845	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1P65_RS04850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1P65_RS04855	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1P65_RS04865	COG3005	denitrification pathway
C1P65_RS04870	COG3043	anaerobic respiration
C1P65_RS04875	COG0348	domain, Protein
C1P65_RS04880	COG0437	4 iron, 4 sulfur cluster binding
C1P65_RS04890	COG3062	negative regulation of establishment of protein localization
C1P65_RS04895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1P65_RS04895	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1P65_RS04910	COG4615	Cyclic peptide transporter
C1P65_RS04915	COG3145	DNA-N1-methyladenine dioxygenase activity
C1P65_RS04920	COG2169	Transcriptional regulator
C1P65_RS04920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1P65_RS04925	COG1477	protein flavinylation
C1P65_RS04930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1P65_RS04940	COG2198	Histidine kinase
C1P65_RS04940	COG0642	Histidine kinase
C1P65_RS04945	COG2197	response regulator
C1P65_RS04950	COG0784	Response regulator, receiver
C1P65_RS04950	COG2205	protein histidine kinase activity
C1P65_RS04960	COG5445	Predicted secreted protein (DUF2300)
C1P65_RS04965	COG2373	Large extracellular alpha-helical protein
C1P65_RS05020	COG0671	phosphoesterase, PA-phosphatase related
C1P65_RS05025	COG1349	DNA-binding transcription factor activity
C1P65_RS05030	COG1686	Belongs to the peptidase S11 family
C1P65_RS05045	COG0625	glutathione transferase activity
C1P65_RS05050	COG2133	pyrroloquinoline quinone binding
C1P65_RS05080	COG1881	PFAM PEBP family protein
C1P65_RS05085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1P65_RS05100	COG2226	methyltransferase
C1P65_RS05105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1P65_RS05115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1P65_RS05135	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1P65_RS05140	COG0314	molybdopterin synthase activity
C1P65_RS05180	COG0392	lysyltransferase activity
C1P65_RS05185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1P65_RS05190	COG3568	Endonuclease Exonuclease Phosphatase
C1P65_RS05200	COG0842	Transport permease protein
C1P65_RS05205	COG0842	Transport permease protein
C1P65_RS05210	COG1131	(ABC) transporter
C1P65_RS05220	COG1309	transcriptional regulator
C1P65_RS05225	COG0513	Belongs to the DEAD box helicase family
C1P65_RS05255	COG1199	ATP-dependent helicase activity
C1P65_RS05260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1P65_RS05265	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1P65_RS05275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1P65_RS05325	COG1126	abc transporter atp-binding protein
C1P65_RS05330	COG0765	amino acid transport
C1P65_RS05335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1P65_RS05360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C1P65_RS05365	COG2194	sulfuric ester hydrolase activity
C1P65_RS05375	COG1321	iron dependent repressor
C1P65_RS05385	COG1376	ErfK ybiS ycfS ynhG family protein
C1P65_RS05390	COG0488	(ABC) transporter
C1P65_RS05460	COG1882	Formate acetyltransferase
C1P65_RS05465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1P65_RS05470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1P65_RS05475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1P65_RS05480	COG0303	'Molybdopterin
C1P65_RS05485	COG1446	asparaginase
C1P65_RS05520	COG0738	Major facilitator superfamily
C1P65_RS05525	COG3226	Transcriptional regulator
C1P65_RS05545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1P65_RS05555	COG0778	Nitroreductase
C1P65_RS05570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1P65_RS05575	COG3842	ATPase activity
C1P65_RS05580	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1P65_RS05585	COG1177	transmembrane transport
C1P65_RS05630	COG1783	phage Terminase large subunit
C1P65_RS05690	COG0582	viral genome integration into host DNA
C1P65_RS05705	COG4149	molybdate abc transporter
C1P65_RS05710	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1P65_RS05720	COG3585	molybdate ion transport
C1P65_RS05720	COG2005	Transcriptional regulator
C1P65_RS05725	COG1119	ATPase activity
C1P65_RS05730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1P65_RS05735	COG1085	galactose-1-phosphate uridylyltransferase
C1P65_RS05745	COG2017	converts alpha-aldose to the beta-anomer
C1P65_RS05755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1P65_RS05775	COG1230	cation diffusion facilitator family transporter
C1P65_RS05780	COG3201	nicotinamide mononucleotide transporter
C1P65_RS05805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1P65_RS05810	COG2885	chlorophyll binding
C1P65_RS05820	COG3064	Membrane
C1P65_RS05825	COG0848	biopolymer transport protein
C1P65_RS05830	COG0811	peptide transport
C1P65_RS05835	COG0824	Thioesterase
C1P65_RS05840	COG3790	cyd operon protein YbgE
C1P65_RS05845	COG4890	Cyd operon protein YbgT
C1P65_RS05850	COG1294	oxidase, subunit
C1P65_RS05855	COG1271	oxidase subunit
C1P65_RS05875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1P65_RS05890	COG3799	methylaspartate ammonia-lyase activity
C1P65_RS05930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1P65_RS05940	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1P65_RS05945	COG0567	Dehydrogenase, E1 component
C1P65_RS05950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1P65_RS05955	COG1053	succinate dehydrogenase
C1P65_RS05960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1P65_RS05965	COG2009	succinate dehydrogenase
C1P65_RS05975	COG0372	Belongs to the citrate synthase family
C1P65_RS05985	COG3539	Fimbrial protein
C1P65_RS06010	COG3539	Fimbrial protein
C1P65_RS06015	COG3180	Ammonia monooxygenase
C1P65_RS06030	COG1984	allophanate hydrolase subunit 2
C1P65_RS06035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1P65_RS06040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1P65_RS06050	COG0415	Belongs to the DNA photolyase family
C1P65_RS06055	COG3272	Protein of unknown function (DUF1722)
C1P65_RS06105	COG0745	RESPONSE REGULATOR receiver
C1P65_RS06110	COG0033	Phosphoglucomutase
C1P65_RS06120	COG0596	Alpha beta hydrolase
C1P65_RS06130	COG0716	FMN binding
C1P65_RS06140	COG0735	belongs to the Fur family
C1P65_RS06180	COG1263	PTS System
C1P65_RS06180	COG2190	(PTS) system
C1P65_RS06180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1P65_RS06190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1P65_RS06195	COG1940	carbohydrate kinase activity
C1P65_RS06195	COG1846	Transcriptional regulator
C1P65_RS06200	COG0647	UMP catabolic process
C1P65_RS06205	COG0367	asparagine synthase
C1P65_RS06240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1P65_RS06250	COG1702	phosphate starvation-inducible protein PhoH
C1P65_RS06260	COG4535	Mg2 and Co2 transporter CorC
C1P65_RS06265	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1P65_RS06270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1P65_RS06290	COG0765	amino acid transport
C1P65_RS06380	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1P65_RS06385	COG2888	peptidyl-tyrosine sulfation
C1P65_RS06405	COG1466	dna polymerase III delta subunit
C1P65_RS06420	COG0799	negative regulation of ribosome biogenesis
C1P65_RS06430	COG0768	penicillin binding
C1P65_RS06435	COG0772	Belongs to the SEDS family
C1P65_RS06440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1P65_RS06445	COG1686	Belongs to the peptidase S11 family
C1P65_RS06470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1P65_RS06500	COG0589	response to stress
C1P65_RS06505	COG3634	alkyl hydroperoxide reductase activity
C1P65_RS06510	COG0450	alkyl hydroperoxide reductase
C1P65_RS06535	COG3969	phosphoadenosine phosphosulfate
C1P65_RS06565	COG0371	Dehydrogenase
C1P65_RS06570	COG2879	small protein
C1P65_RS06580	COG2050	protein possibly involved in aromatic compounds catabolism
C1P65_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS06590	COG3433	isochorismatase activity
C1P65_RS06590	COG1535	isochorismatase
C1P65_RS06595	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1P65_RS06600	COG1169	isochorismate synthase
C1P65_RS06605	COG4592	Periplasmic binding protein
C1P65_RS06615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1P65_RS06620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1P65_RS06625	COG1120	ATPase activity
C1P65_RS06630	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C1P65_RS06640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1P65_RS06640	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C1P65_RS06645	COG3251	PFAM MbtH domain protein
C1P65_RS06650	COG2382	esterase
C1P65_RS06655	COG4771	TonB-dependent receptor
C1P65_RS06660	COG2977	Belongs to the P-Pant transferase superfamily
C1P65_RS06685	COG4521	taurine ABC transporter
C1P65_RS06695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1P65_RS06700	COG2175	clavaminate synthase activity
C1P65_RS06705	COG0113	porphobilinogen synthase activity
C1P65_RS06750	COG2315	Protein conserved in bacteria
C1P65_RS06755	COG0778	Nitroreductase
C1P65_RS06760	COG0668	transmembrane transport
C1P65_RS06765	COG1113	amino acid transport
C1P65_RS06805	COG1690	Belongs to the RtcB family
C1P65_RS06810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1P65_RS06815	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1P65_RS06890	COG0110	maltose O-acetyltransferase activity
C1P65_RS06905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1P65_RS06910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1P65_RS06915	COG1309	transcriptional regulator
C1P65_RS06920	COG1196	nuclear chromosome segregation
C1P65_RS06920	COG3264	Mechanosensitive ion channel
C1P65_RS06930	COG3923	Primosomal replication protein n
C1P65_RS06935	COG2832	Protein of unknown function (DUF454)
C1P65_RS06945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1P65_RS06980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1P65_RS06985	COG4651	solute:proton antiporter activity
C1P65_RS06985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1P65_RS06995	COG3385	transposase activity
C1P65_RS07005	COG0737	Belongs to the 5'-nucleotidase family
C1P65_RS07010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1P65_RS07015	COG3735	TraB family
C1P65_RS07025	COG3093	addiction module antidote protein HigA
C1P65_RS07030	COG2217	Heavy metal translocating P-type atpase
C1P65_RS07040	COG0531	amino acid
C1P65_RS07095	COG0789	Transcriptional regulator
C1P65_RS07115	COG1585	Membrane protein implicated in regulation of membrane protease activity
C1P65_RS07120	COG0330	HflC and HflK could
C1P65_RS07125	COG4619	ABC transporter
C1P65_RS07130	COG0390	transport system, permease component
C1P65_RS07135	COG3118	belongs to the thioredoxin family
C1P65_RS07140	COG0300	oxidoreductase activity
C1P65_RS07145	COG2755	lipolytic protein G-D-S-L family
C1P65_RS07150	COG4181	ATPase activity
C1P65_RS07180	COG0583	DNA-binding transcription factor activity
C1P65_RS07190	COG1414	Transcriptional regulator
C1P65_RS07210	COG5507	3-demethylubiquinone-9 3-methyltransferase
C1P65_RS07220	COG3695	enzyme binding
C1P65_RS07230	COG1946	Acyl-CoA thioesterase
C1P65_RS07235	COG0004	ammonium transporteR
C1P65_RS07240	COG0347	Belongs to the P(II) protein family
C1P65_RS07245	COG1132	(ABC) transporter
C1P65_RS07250	COG1132	(ABC) transporter
C1P65_RS07255	COG1522	sequence-specific DNA binding
C1P65_RS07275	COG1609	Transcriptional regulator
C1P65_RS07330	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C1P65_RS07350	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1P65_RS07405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1P65_RS07425	COG4126	flavin adenine dinucleotide binding
C1P65_RS07500	COG0419	ATPase involved in DNA repair
C1P65_RS07510	COG3385	transposase activity
C1P65_RS07530	COG1114	Component of the transport system for branched-chain amino acids
C1P65_RS07535	COG1113	amino acid transport
C1P65_RS07570	COG1862	Preprotein translocase
C1P65_RS07575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1P65_RS07580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1P65_RS07585	COG1403	HNH endonuclease
C1P65_RS07590	COG3248	Nucleoside-binding outer membrane protein
C1P65_RS07595	COG4238	major outer membrane lipoprotein
C1P65_RS07605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1P65_RS07605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1P65_RS07620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1P65_RS07625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1P65_RS07660	COG0667	Aldo Keto reductase
C1P65_RS07670	COG0142	geranyltranstransferase activity
C1P65_RS07685	COG0693	protein deglycase activity
C1P65_RS07690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1P65_RS07700	COG2814	Major facilitator Superfamily
C1P65_RS07710	COG2223	nitrite transmembrane transporter activity
C1P65_RS07715	COG3056	Lipoprotein
C1P65_RS07720	COG0271	Belongs to the BolA IbaG family
C1P65_RS07740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1P65_RS07745	COG0776	regulation of translation
C1P65_RS07750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1P65_RS07755	COG1555	photosystem II stabilization
C1P65_RS07765	COG0824	Thioesterase
C1P65_RS07815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1P65_RS07825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1P65_RS07830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1P65_RS07880	COG2207	Transcriptional regulator
C1P65_RS07905	COG3121	Chaperone
C1P65_RS07920	COG0791	NLP P60 protein
C1P65_RS07925	COG3077	Addiction module antitoxin, RelB DinJ family
C1P65_RS07930	COG3041	Addiction module toxin RelE StbE family
C1P65_RS07935	COG3034	peptidoglycan biosynthetic process
C1P65_RS07940	COG0121	glutamine amidotransferase
C1P65_RS07960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1P65_RS08015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1P65_RS08025	COG2226	methyltransferase
C1P65_RS08035	COG1388	LysM domain
C1P65_RS08035	COG0741	lytic transglycosylase activity
C1P65_RS08050	COG0583	DNA-binding transcription factor activity
C1P65_RS08055	COG0656	L-ascorbic acid biosynthetic process
C1P65_RS08090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1P65_RS08100	COG2011	ABC-type metal ion transport system permease component
C1P65_RS08105	COG1464	Belongs to the NlpA lipoprotein family
C1P65_RS08115	COG1720	tRNA m6t6A37 methyltransferase activity
C1P65_RS08125	COG0791	NLP P60 protein
C1P65_RS08130	COG3015	lipoprotein NlpE involved in copper resistance
C1P65_RS08135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1P65_RS08140	COG4681	YaeQ
C1P65_RS08150	COG4568	rho-dependent transcription termination
C1P65_RS08160	COG0346	lactoylglutathione lyase activity
C1P65_RS08185	COG0587	DNA-directed DNA polymerase activity
C1P65_RS08210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1P65_RS08215	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C1P65_RS08230	COG0575	Belongs to the CDS family
C1P65_RS08235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1P65_RS08240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1P65_RS08265	COG0024	Methionine aminopeptidase
C1P65_RS08290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1P65_RS08320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1P65_RS08325	COG2860	membrane
C1P65_RS08350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1P65_RS08355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1P65_RS08360	COG1120	ATPase activity
C1P65_RS08365	COG4774	siderophore transport
C1P65_RS08370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1P65_RS08380	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C1P65_RS08390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1P65_RS08395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1P65_RS08400	COG0617	tRNA 3'-terminal CCA addition
C1P65_RS08405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1P65_RS08455	COG3188	usher protein
C1P65_RS08475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1P65_RS08480	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1P65_RS08485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1P65_RS08490	COG2186	Transcriptional regulator
C1P65_RS08495	COG1113	amino acid transport
C1P65_RS08500	COG3725	Membrane protein required for beta-lactamase induction
C1P65_RS08505	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1P65_RS08510	COG0157	Belongs to the NadC ModD family
C1P65_RS08515	COG4969	Belongs to the N-Me-Phe pilin family
C1P65_RS08520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1P65_RS08535	COG0237	dephospho-CoA kinase activity
C1P65_RS08550	COG0494	nUDIX hydrolase
C1P65_RS08570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1P65_RS08575	COG0849	cell division
C1P65_RS08585	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1P65_RS08600	COG0772	Belongs to the SEDS family
C1P65_RS08615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1P65_RS08620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1P65_RS08625	COG0768	penicillin binding
C1P65_RS08630	COG3116	cell division
C1P65_RS08645	COG1609	Transcriptional regulator
C1P65_RS08655	COG0440	acetolactate synthase activity
C1P65_RS08660	COG0028	Belongs to the TPP enzyme family
C1P65_RS08730	COG4143	(ABC) transporter
C1P65_RS08735	COG1178	ABC-type Fe3 transport system permease component
C1P65_RS08745	COG0586	Pfam SNARE associated Golgi protein
C1P65_RS08765	COG0235	Class ii aldolase
C1P65_RS08770	COG0417	DNA replication proofreading
C1P65_RS08800	COG0564	pseudouridine synthase activity
C1P65_RS08810	COG1357	PFAM Pentapeptide repeats (8 copies)
C1P65_RS08815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1P65_RS08860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1P65_RS08885	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C1P65_RS08940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1P65_RS08945	COG0505	Belongs to the CarA family
C1P65_RS08965	COG1047	Peptidyl-prolyl cis-trans
C1P65_RS08980	COG0196	riboflavin kinase activity
C1P65_RS09000	COG5464	transposase or invertase
C1P65_RS09010	COG0726	polysaccharide deacetylase
C1P65_RS09015	COG0726	polysaccharide deacetylase
C1P65_RS09020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS09025	COG0842	Transport permease protein
C1P65_RS09030	COG1131	(ABC) transporter
C1P65_RS09035	COG0288	reversible hydration of carbon dioxide
C1P65_RS09040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1P65_RS09060	COG2132	Multicopper oxidase
C1P65_RS09085	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1P65_RS09110	COG0583	DNA-binding transcription factor activity
C1P65_RS09145	COG4735	regulation of single-species biofilm formation
C1P65_RS09150	COG1584	GPR1 FUN34 yaaH family protein
C1P65_RS09155	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1P65_RS09180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1P65_RS09190	COG0460	homoserine dehydrogenase
C1P65_RS09190	COG0527	aspartate kinase activity
C1P65_RS09200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1P65_RS09210	COG0745	RESPONSE REGULATOR receiver
C1P65_RS09215	COG4452	Inner membrane protein CreD
C1P65_RS09225	COG0745	RESPONSE REGULATOR receiver
C1P65_RS09230	COG3045	CreA protein
C1P65_RS09235	COG2207	Transcriptional regulator
C1P65_RS09235	COG3708	Transcriptional regulator
C1P65_RS09255	COG0741	lytic transglycosylase activity
C1P65_RS09260	COG0488	(ABC) transporter
C1P65_RS09265	COG1056	cytidyltransferase-related domain
C1P65_RS09265	COG3172	ATPase kinase involved in NAD metabolism
C1P65_RS09270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1P65_RS09275	COG0560	Phosphoserine phosphatase
C1P65_RS09280	COG3726	membrane protein affecting hemolysin expression
C1P65_RS09320	COG1328	CTP reductase activity
C1P65_RS09325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1P65_RS09330	COG0084	hydrolase, TatD family'
C1P65_RS09335	COG4667	esterase of the alpha-beta hydrolase superfamily
C1P65_RS09345	COG2823	Periplasmic or secreted lipoprotein
C1P65_RS09355	COG1011	Hydrolase
C1P65_RS09360	COG0456	acetyltransferase
C1P65_RS09365	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C1P65_RS09395	COG4114	ferric iron reductase
C1P65_RS09425	COG2966	Psort location CytoplasmicMembrane, score
C1P65_RS09440	COG1484	DNA-dependent DNA replication
C1P65_RS09470	COG2271	Major facilitator Superfamily
C1P65_RS09480	COG1966	Carbon starvation protein
C1P65_RS09485	COG2879	small protein
C1P65_RS09490	COG0523	cobalamin synthesis protein
C1P65_RS09505	COG5457	Domain of unknown function (DUF1127)
C1P65_RS09510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1P65_RS09520	COG2814	Major facilitator Superfamily
C1P65_RS09535	COG1924	4 iron, 4 sulfur cluster binding
C1P65_RS09585	COG2003	Belongs to the UPF0758 family
C1P65_RS09695	COG0747	negative chemotaxis
C1P65_RS09705	COG0601	transmembrane transport
C1P65_RS09710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1P65_RS09715	COG0444	Belongs to the ABC transporter superfamily
C1P65_RS09720	COG4608	Belongs to the ABC transporter superfamily
C1P65_RS09725	COG0814	amino acid
C1P65_RS09780	COG1215	transferase activity, transferring glycosyl groups
C1P65_RS09785	COG1215	transferase activity, transferring glycosyl groups
C1P65_RS09795	COG3118	belongs to the thioredoxin family
C1P65_RS09795	COG0457	Tetratricopeptide repeat
C1P65_RS09800	COG0457	Tetratricopeptide repeat
C1P65_RS09800	COG3118	belongs to the thioredoxin family
C1P65_RS09805	COG2200	EAL domain
C1P65_RS09805	COG2199	diguanylate cyclase activity
C1P65_RS09815	COG0612	Peptidase, M16
C1P65_RS09825	COG2200	EAL domain
C1P65_RS09830	COG2982	Protein involved in outer membrane biogenesis
C1P65_RS09835	COG0477	Major facilitator Superfamily
C1P65_RS09840	COG1295	ribonuclease BN
C1P65_RS09860	COG1566	PFAM secretion protein HlyD family protein
C1P65_RS09890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1P65_RS09900	COG0534	Mate efflux family protein
C1P65_RS09905	COG3237	CsbD-like
C1P65_RS09910	COG0735	belongs to the Fur family
C1P65_RS09925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1P65_RS09935	COG0604	alcohol dehydrogenase
C1P65_RS09940	COG0305	Participates in initiation and elongation during chromosome replication
C1P65_RS09950	COG1448	Aminotransferase
C1P65_RS09990	COG0432	Pfam Uncharacterised protein family UPF0047
C1P65_RS09995	COG2315	Protein conserved in bacteria
C1P65_RS10000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1P65_RS10005	COG0629	single-stranded DNA binding
C1P65_RS10025	COG2207	Transcriptional regulator
C1P65_RS10030	COG0789	Transcriptional regulator
C1P65_RS10035	COG2252	PERMEase
C1P65_RS10040	COG0025	NhaP-type Na H and K H
C1P65_RS10050	COG1464	Belongs to the NlpA lipoprotein family
C1P65_RS10055	COG0697	spore germination
C1P65_RS10095	COG0582	viral genome integration into host DNA
C1P65_RS10155	COG3436	PFAM IS66 Orf2 family protein
C1P65_RS10160	COG4372	Transposase
C1P65_RS10170	COG2197	response regulator
C1P65_RS10255	COG3104	oligopeptide transport
C1P65_RS10280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1P65_RS10285	COG2337	Toxic component of a toxin-antitoxin (TA) module
C1P65_RS10290	COG2336	PFAM SpoVT AbrB
C1P65_RS10295	COG2105	PFAM AIG2 family protein
C1P65_RS10300	COG2911	Protein conserved in bacteria
C1P65_RS10305	COG0729	surface antigen
C1P65_RS10315	COG1253	flavin adenine dinucleotide binding
C1P65_RS10325	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1P65_RS10365	COG0531	amino acid
C1P65_RS10375	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1P65_RS10380	COG1027	Aspartate ammonia-lyase
C1P65_RS10385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1P65_RS10430	COG0531	amino acid
C1P65_RS10435	COG3264	Mechanosensitive ion channel
C1P65_RS10435	COG1511	domain protein
C1P65_RS10475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1P65_RS10475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1P65_RS10480	COG0802	atpase or kinase
C1P65_RS10485	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1P65_RS10505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1P65_RS10510	COG0330	HflC and HflK could
C1P65_RS10515	COG0330	HflC and HflK could
C1P65_RS10520	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1P65_RS10535	COG0557	exoribonuclease II activity
C1P65_RS10540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1P65_RS10555	COG1960	acyl-CoA dehydrogenase activity
C1P65_RS10560	COG0754	glutathionylspermidine amidase activity
C1P65_RS10565	COG5463	Belongs to the UPF0441 family
C1P65_RS10580	COG1053	succinate dehydrogenase
C1P65_RS10585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1P65_RS10600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1P65_RS10605	COG3040	lipid binding
C1P65_RS10610	COG2076	Multidrug Resistance protein
C1P65_RS10615	COG5510	response to toxic substance
C1P65_RS10620	COG5510	response to toxic substance
C1P65_RS10630	COG1509	lysine 2,3-aminomutase activity
C1P65_RS10645	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1P65_RS10655	COG0737	Belongs to the 5'-nucleotidase family
C1P65_RS10660	COG1733	regulation of RNA biosynthetic process
C1P65_RS10665	COG0702	epimerase
C1P65_RS10670	COG0697	spore germination
C1P65_RS10680	COG1113	amino acid transport
C1P65_RS10685	COG0545	Peptidyl-prolyl cis-trans isomerase
C1P65_RS10690	COG3061	Opacity-associated protein A
C1P65_RS10740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1P65_RS10800	COG1073	alpha beta
C1P65_RS10805	COG3650	response to hydrogen peroxide
C1P65_RS10830	COG2818	Glycosylase
C1P65_RS10840	COG0243	molybdopterin cofactor binding
C1P65_RS10860	COG2944	sequence-specific DNA binding
C1P65_RS10865	COG1278	Cold shock
C1P65_RS10905	COG3274	enterobacterial common antigen metabolic process
C1P65_RS10925	COG3385	transposase activity
C1P65_RS10935	COG0456	acetyltransferase
C1P65_RS10955	COG2224	Isocitrate lyase
C1P65_RS10980	COG1414	Transcriptional regulator
C1P65_RS10985	COG0646	methionine synthase
C1P65_RS10985	COG1410	methionine synthase
C1P65_RS10995	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1P65_RS11040	COG1187	pseudouridine synthase activity
C1P65_RS11090	COG4372	Transposase
C1P65_RS11145	COG1595	DNA-templated transcription, initiation
C1P65_RS11155	COG4772	TonB-dependent receptor
C1P65_RS11165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1P65_RS11170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1P65_RS11175	COG1120	ATPase activity
C1P65_RS11180	COG2085	NADP oxidoreductase coenzyme F420-dependent
C1P65_RS11200	COG1064	alcohol dehydrogenase
C1P65_RS11210	COG0795	lipopolysaccharide-transporting ATPase activity
C1P65_RS11215	COG0795	lipopolysaccharide-transporting ATPase activity
C1P65_RS11225	COG2927	DNA polymerase III (CHI subunit)
C1P65_RS11235	COG4269	membrane
C1P65_RS11265	COG0456	acetyltransferase
C1P65_RS11270	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C1P65_RS11305	COG2731	YhcH YjgK YiaL family protein
C1P65_RS11315	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS11320	COG0251	oxidation-reduction process
C1P65_RS11340	COG0251	oxidation-reduction process
C1P65_RS11345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1P65_RS11355	COG1609	Transcriptional regulator
C1P65_RS11360	COG1263	PTS System
C1P65_RS11360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1P65_RS11365	COG0366	Alpha amylase catalytic
C1P65_RS11370	COG1328	CTP reductase activity
C1P65_RS11375	COG0602	queuosine metabolic process
C1P65_RS11380	COG3077	Addiction module antitoxin, RelB DinJ family
C1P65_RS11390	COG3783	Cytochrome b(562)
C1P65_RS11395	COG0312	modulator of DNA gyrase
C1P65_RS11405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1P65_RS11415	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1P65_RS11425	COG1129	ABC transporter
C1P65_RS11430	COG1879	ABC-type sugar transport system periplasmic component
C1P65_RS11460	COG2388	GCN5-related N-acetyl-transferase
C1P65_RS11465	COG3592	Divergent 4Fe-4S mono-cluster
C1P65_RS11475	COG3290	protein histidine kinase activity
C1P65_RS11480	COG4565	transcriptional regulatory protein
C1P65_RS11500	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1P65_RS11505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C1P65_RS11505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C1P65_RS11520	COG2211	Major facilitator Superfamily
C1P65_RS11530	COG0527	aspartate kinase activity
C1P65_RS11610	COG3833	ABC-type maltose transport systems, permease component
C1P65_RS11630	COG2182	Extracellular solute-binding protein
C1P65_RS11635	COG3842	ATPase activity
C1P65_RS11665	COG3276	selenocysteine insertion sequence binding
C1P65_RS11675	COG0625	glutathione transferase activity
C1P65_RS11680	COG3209	COG3209 Rhs family protein
C1P65_RS11700	COG0814	amino acid
C1P65_RS11715	COG2091	lysine biosynthetic process via aminoadipic acid
C1P65_RS11725	COG2252	PERMEase
C1P65_RS11730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1P65_RS11795	COG0592	DNA-directed DNA polymerase activity
C1P65_RS11805	COG0187	DNA topoisomerase II activity
C1P65_RS11810	COG3753	Protein conserved in bacteria
C1P65_RS11815	COG0561	phosphatase activity
C1P65_RS11840	COG0823	Involved in the tonB-independent uptake of proteins
C1P65_RS11845	COG5645	(Lipo)protein
C1P65_RS11865	COG2188	Transcriptional regulator
C1P65_RS11870	COG1263	PTS System
C1P65_RS11900	COG2207	Transcriptional regulator
C1P65_RS11905	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1P65_RS11910	COG3119	arylsulfatase activity
C1P65_RS11920	COG2149	membrane
C1P65_RS11930	COG0641	radical SAM
C1P65_RS11935	COG2814	Major facilitator Superfamily
C1P65_RS11950	COG0028	Belongs to the TPP enzyme family
C1P65_RS11955	COG0440	acetolactate synthase activity
C1P65_RS11995	COG2197	response regulator
C1P65_RS12000	COG3851	Histidine kinase
C1P65_RS12005	COG2271	Major facilitator Superfamily
C1P65_RS12010	COG2271	Major facilitator Superfamily
C1P65_RS12060	COG4932	domain protein
C1P65_RS12060	COG2373	Large extracellular alpha-helical protein
C1P65_RS12060	COG1388	LysM domain
C1P65_RS12130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1P65_RS12135	COG0456	acetyltransferase
C1P65_RS12145	COG3454	Phosphonate metabolism
C1P65_RS12150	COG4778	phosphonate C-P lyase system protein PhnL
C1P65_RS12155	COG4107	phosphonate C-P lyase system protein PhnK
C1P65_RS12160	COG3627	carbon phosphorus lyase activity
C1P65_RS12165	COG3626	phosphonate metabolism
C1P65_RS12170	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C1P65_RS12180	COG2188	Transcriptional regulator
C1P65_RS12185	COG3639	organic phosphonate transmembrane transporter activity
C1P65_RS12190	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C1P65_RS12205	COG2824	Alkylphosphonate utilization operon protein PhnA
C1P65_RS12235	COG0477	Major facilitator Superfamily
C1P65_RS12245	COG0642	Histidine kinase
C1P65_RS12255	COG2194	sulfuric ester hydrolase activity
C1P65_RS12260	COG0531	amino acid
C1P65_RS12265	COG2207	Transcriptional regulator
C1P65_RS12275	COG1982	Orn Lys Arg decarboxylase major
C1P65_RS12285	COG1486	melibiose metabolic process
C1P65_RS12290	COG2211	Major facilitator Superfamily
C1P65_RS12305	COG2982	Protein involved in outer membrane biogenesis
C1P65_RS12310	COG2233	PERMEase
C1P65_RS12315	COG0786	glutamate:sodium symporter activity
C1P65_RS12320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1P65_RS12325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1P65_RS12330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1P65_RS12355	COG2860	membrane
C1P65_RS12360	COG3645	SOS response
C1P65_RS12365	COG1561	YicC-like family, N-terminal region
C1P65_RS12395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1P65_RS12425	COG1519	Transferase
C1P65_RS12430	COG0859	PFAM glycosyl transferase family 9
C1P65_RS12435	COG0438	transferase activity, transferring glycosyl groups
C1P65_RS12440	COG0515	serine threonine protein kinase
C1P65_RS12455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1P65_RS12460	COG1442	glycosyl transferase family 8
C1P65_RS12470	COG3307	-O-antigen
C1P65_RS12475	COG0859	PFAM glycosyl transferase family 9
C1P65_RS12480	COG0859	PFAM glycosyl transferase family 9
C1P65_RS12490	COG0156	8-amino-7-oxononanoate synthase activity
C1P65_RS12500	COG1216	Glycosyl transferase, family 2
C1P65_RS12505	COG2861	carbohydrate metabolic process
C1P65_RS12510	COG4942	peptidase
C1P65_RS12525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1P65_RS12530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1P65_RS12545	COG1045	serine acetyltransferase
C1P65_RS12550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1P65_RS12560	COG2186	Transcriptional regulator
C1P65_RS12625	COG0704	Plays a role in the regulation of phosphate uptake
C1P65_RS12630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1P65_RS12635	COG0581	inorganic phosphate transmembrane transporter activity
C1P65_RS12640	COG0573	inorganic phosphate transmembrane transporter activity
C1P65_RS12645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1P65_RS12665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1P65_RS12715	COG3312	ion transport
C1P65_RS12730	COG0716	FMN binding
C1P65_RS12735	COG1522	sequence-specific DNA binding
C1P65_RS12775	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1P65_RS12785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1P65_RS12790	COG1609	Transcriptional regulator
C1P65_RS12795	COG0477	Major facilitator Superfamily
C1P65_RS12800	COG2186	Transcriptional regulator
C1P65_RS12840	COG3085	chromosome segregation
C1P65_RS12850	COG3547	Transposase (IS116 IS110 IS902 family)
C1P65_RS12875	COG3978	acetolactate synthase activity
C1P65_RS12880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1P65_RS12890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1P65_RS12895	COG0583	DNA-binding transcription factor activity
C1P65_RS12905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1P65_RS12910	COG3692	DNA binding
C1P65_RS12920	COG3692	DNA binding
C1P65_RS12925	COG0210	DNA helicase
C1P65_RS12940	COG3118	belongs to the thioredoxin family
C1P65_RS12950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1P65_RS12955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1P65_RS12960	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C1P65_RS12965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C1P65_RS12970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C1P65_RS12980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1P65_RS12985	COG0456	acetyltransferase
C1P65_RS12990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1P65_RS12995	COG2244	polysaccharide biosynthetic process
C1P65_RS13015	COG1113	amino acid transport
C1P65_RS13055	COG3119	arylsulfatase activity
C1P65_RS13060	COG3071	HemY protein
C1P65_RS13065	COG2959	enzyme of heme biosynthesis
C1P65_RS13070	COG1587	Uroporphyrinogen-III synthase
C1P65_RS13080	COG3072	Adenylate cyclase
C1P65_RS13095	COG5567	small periplasmic lipoprotein
C1P65_RS13105	COG3159	Protein conserved in bacteria
C1P65_RS13115	COG1011	Hydrolase
C1P65_RS13120	COG0210	DNA helicase
C1P65_RS13125	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C1P65_RS13130	COG3698	Phosphodiester glycosidase
C1P65_RS13135	COG0598	Magnesium transport protein CorA
C1P65_RS13155	COG2962	Rard protein
C1P65_RS13160	COG2050	protein possibly involved in aromatic compounds catabolism
C1P65_RS13165	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C1P65_RS13170	COG0514	ATP-dependent DNA helicase (RecQ)
C1P65_RS13175	COG1280	lysine exporter protein (LysE YggA)
C1P65_RS13180	COG1280	lysine exporter protein (LysE YggA)
C1P65_RS13185	COG2267	carboxylic ester hydrolase activity
C1P65_RS13190	COG0561	phosphatase activity
C1P65_RS13195	COG0697	spore germination
C1P65_RS13200	COG0583	DNA-binding transcription factor activity
C1P65_RS13210	COG0412	Dienelactone hydrolase
C1P65_RS13215	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1P65_RS13220	COG1322	Protein conserved in bacteria
C1P65_RS13230	COG3165	ubiquinone biosynthetic process from chorismate
C1P65_RS13240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1P65_RS13250	COG0805	protein transport
C1P65_RS13260	COG0250	Participates in transcription elongation, termination and antitermination
C1P65_RS13270	COG0543	2 iron, 2 sulfur cluster binding
C1P65_RS13290	COG1739	Uncharacterized protein family UPF0029
C1P65_RS13295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1P65_RS13300	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C1P65_RS13330	COG1763	Mo-molybdopterin cofactor biosynthetic process
C1P65_RS13335	COG0746	molybdenum cofactor guanylyltransferase activity
C1P65_RS13340	COG3084	Protein conserved in bacteria
C1P65_RS13345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1P65_RS13350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1P65_RS13360	COG5339	Protein conserved in bacteria
C1P65_RS13365	COG0204	Acyl-transferase
C1P65_RS13375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1P65_RS13375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1P65_RS13385	COG3078	GTPase activator activity
C1P65_RS13390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1P65_RS13400	COG2204	response regulator
C1P65_RS13405	COG3852	Histidine kinase
C1P65_RS13410	COG0174	glutamine synthetase
C1P65_RS13415	COG1217	gtp-binding protein TYPA
C1P65_RS13420	COG3385	transposase activity
C1P65_RS13470	COG1011	Hydrolase
C1P65_RS13485	COG0456	acetyltransferase
C1P65_RS13500	COG2864	formate dehydrogenase
C1P65_RS13505	COG0437	4 iron, 4 sulfur cluster binding
C1P65_RS13580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1P65_RS13590	COG2258	MOSC domain
C1P65_RS13595	COG2205	protein histidine kinase activity
C1P65_RS13600	COG0745	RESPONSE REGULATOR receiver
C1P65_RS13605	COG3678	ATP-independent chaperone mediated protein folding
C1P65_RS13620	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1P65_RS13650	COG3152	Membrane
C1P65_RS13660	COG3691	Protein conserved in bacteria
C1P65_RS13665	COG0589	response to stress
C1P65_RS13675	COG1494	fructose-1,6-bisphosphatase
C1P65_RS13685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1P65_RS13730	COG1575	Belongs to the MenA family. Type 1 subfamily
C1P65_RS13745	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1P65_RS13750	COG1609	Transcriptional regulator
C1P65_RS13755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1P65_RS13790	COG0583	DNA-binding transcription factor activity
C1P65_RS13805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1P65_RS13820	COG2194	sulfuric ester hydrolase activity
C1P65_RS13825	COG2207	Transcriptional regulator
C1P65_RS13830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1P65_RS13835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1P65_RS13840	COG1882	Formate acetyltransferase
C1P65_RS13845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1P65_RS13850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1P65_RS13855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS13855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1P65_RS13855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS13860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1P65_RS13865	COG0371	Dehydrogenase
C1P65_RS13870	COG3738	Protein conserved in bacteria
C1P65_RS13875	COG0697	spore germination
C1P65_RS13885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1P65_RS13895	COG0527	aspartate kinase activity
C1P65_RS13895	COG0460	homoserine dehydrogenase
C1P65_RS13900	COG0626	cystathionine gamma-synthase activity
C1P65_RS13910	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C1P65_RS13940	COG1309	transcriptional regulator
C1P65_RS13960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1P65_RS13990	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C1P65_RS13990	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C1P65_RS14025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1P65_RS14030	COG0250	Participates in transcription elongation, termination and antitermination
C1P65_RS14080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1P65_RS14090	COG2104	thiamine diphosphate biosynthetic process
C1P65_RS14095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1P65_RS14130	COG3068	Protein conserved in bacteria
C1P65_RS14145	COG3678	ATP-independent chaperone mediated protein folding
C1P65_RS14150	COG4191	Histidine kinase
C1P65_RS14155	COG2204	response regulator
C1P65_RS14160	COG0151	Belongs to the GarS family
C1P65_RS14210	COG1609	Transcriptional regulator
C1P65_RS14210	COG2207	Transcriptional regulator
C1P65_RS14215	COG2992	FlgJ-related protein
C1P65_RS14225	COG3977	Valine--pyruvate aminotransferase
C1P65_RS14230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1P65_RS14235	COG1414	Transcriptional regulator
C1P65_RS14260	COG1735	metal-dependent hydrolase with the TIM-barrel fold
C1P65_RS14265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1P65_RS14290	COG2188	Transcriptional regulator
C1P65_RS14295	COG0180	Tryptophanyl-tRNA synthetase
C1P65_RS14305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1P65_RS14310	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1P65_RS14315	COG3266	domain, Protein
C1P65_RS14345	COG3166	PFAM Fimbrial assembly family protein
C1P65_RS14355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1P65_RS14360	COG0494	nUDIX hydrolase
C1P65_RS14370	COG1011	Hydrolase
C1P65_RS14375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1P65_RS14390	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C1P65_RS14410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1P65_RS14415	COG2183	response to ionizing radiation
C1P65_RS14420	COG1918	ferrous iron import across plasma membrane
C1P65_RS14425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C1P65_RS14435	COG5464	transposase or invertase
C1P65_RS14455	COG2610	gluconate transmembrane transporter activity
C1P65_RS14460	COG1640	4-alpha-glucanotransferase
C1P65_RS14465	COG0058	SHG alpha-glucan phosphorylase activity
C1P65_RS14500	COG1349	DNA-binding transcription factor activity
C1P65_RS14515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1P65_RS14550	COG3414	Phosphotransferase system galactitol-specific IIB component
C1P65_RS14580	COG2188	Transcriptional regulator
C1P65_RS14600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1P65_RS14605	COG0601	transmembrane transport
C1P65_RS14610	COG0747	negative chemotaxis
C1P65_RS14615	COG2091	lysine biosynthetic process via aminoadipic acid
C1P65_RS14620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1P65_RS14665	COG1216	Glycosyl transferase, family 2
C1P65_RS14670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1P65_RS14685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1P65_RS14735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1P65_RS14760	COG3776	membrane
C1P65_RS14765	COG0742	ribosomal rna small subunit methyltransferase
C1P65_RS14770	COG0552	protein localization to endoplasmic reticulum
C1P65_RS14775	COG2884	Cell division ATP-binding protein ftsE
C1P65_RS14780	COG2177	Part of the ABC transporter FtsEX involved in
C1P65_RS14785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1P65_RS14790	COG0683	leucine binding
C1P65_RS14805	COG0683	leucine binding
C1P65_RS14810	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1P65_RS14815	COG4177	L-phenylalanine transmembrane transporter activity
C1P65_RS14820	COG0411	ABC transporter
C1P65_RS14825	COG0410	ABC transporter
C1P65_RS14865	COG0405	Gamma-glutamyltransferase
C1P65_RS14885	COG1247	-acetyltransferase
C1P65_RS14890	COG0673	inositol 2-dehydrogenase activity
C1P65_RS14895	COG1741	Belongs to the pirin family
C1P65_RS14900	COG1609	Transcriptional regulator
C1P65_RS14905	COG3265	gluconokinase activity
C1P65_RS14910	COG2610	gluconate transmembrane transporter activity
C1P65_RS14945	COG2095	MarC family integral membrane protein
C1P65_RS14950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1P65_RS14975	COG0058	SHG alpha-glucan phosphorylase activity
C1P65_RS14995	COG2081	HI0933 family
C1P65_RS15000	COG0306	phosphate transporter
C1P65_RS15010	COG0589	response to stress
C1P65_RS15030	COG0339	signal peptide processing
C1P65_RS15035	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1P65_RS15040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1P65_RS15050	COG0640	Transcriptional regulator
C1P65_RS15055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C1P65_RS15060	COG1393	Belongs to the ArsC family
C1P65_RS15070	COG3065	identical protein binding
C1P65_RS15075	COG2197	response regulator
C1P65_RS15080	COG3720	iron ion transport
C1P65_RS15085	COG4771	TonB-dependent receptor
C1P65_RS15095	COG4558	Periplasmic binding protein
C1P65_RS15105	COG3721	Heme iron utilization protein
C1P65_RS15115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1P65_RS15150	COG3247	response to pH
C1P65_RS15160	COG2771	luxR family
C1P65_RS15170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1P65_RS15175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1P65_RS15195	COG2207	Transcriptional regulator
C1P65_RS15215	COG2116	formate transmembrane transporter activity
C1P65_RS15220	COG2146	nitrite reductase [NAD(P)H] activity
C1P65_RS15225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1P65_RS15240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1P65_RS15250	COG2184	nucleotidyltransferase activity
C1P65_RS15255	COG0512	Glutamine amidotransferase of anthranilate synthase
C1P65_RS15260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1P65_RS15265	COG1289	transmembrane transporter activity
C1P65_RS15270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1P65_RS15275	COG1765	OsmC-like protein
C1P65_RS15280	COG3954	Phosphoribulokinase
C1P65_RS15295	COG0488	(ABC) transporter
C1P65_RS15310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C1P65_RS15315	COG1047	Peptidyl-prolyl cis-trans
C1P65_RS15325	COG0545	Peptidyl-prolyl cis-trans isomerase
C1P65_RS15330	COG2964	Protein conserved in bacteria
C1P65_RS15495	COG0201	protein transport
C1P65_RS15535	COG0789	Transcriptional regulator
C1P65_RS15540	COG3036	rescue of stalled ribosome
C1P65_RS15550	COG0569	domain protein
C1P65_RS15570	COG0758	DNA mediated transformation
C1P65_RS15580	COG0551	DNA topoisomerase type I activity
C1P65_RS15600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1P65_RS15645	COG0765	amino acid transport
C1P65_RS15655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1P65_RS15680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C1P65_RS15690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1P65_RS15700	COG4145	pantothenate transmembrane transporter activity
C1P65_RS15705	COG3924	membrane
C1P65_RS15710	COG0439	Biotin carboxylase
C1P65_RS15715	COG0511	ligase activity, forming carbon-carbon bonds
C1P65_RS15725	COG0604	alcohol dehydrogenase
C1P65_RS15730	COG2199	diguanylate cyclase activity
C1P65_RS15730	COG2200	EAL domain
C1P65_RS15740	COG1077	Cell shape determining protein MreB Mrl
C1P65_RS15745	COG1792	Involved in formation and maintenance of cell shape
C1P65_RS15750	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1P65_RS15760	COG1530	ribonuclease E activity
C1P65_RS15765	COG3164	Protein of unknown function
C1P65_RS15770	COG0312	modulator of DNA gyrase
C1P65_RS15775	COG0583	DNA-binding transcription factor activity
C1P65_RS15795	COG2732	(Barnase) inhibitor
C1P65_RS15815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1P65_RS15820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1P65_RS15825	COG3105	Protein conserved in bacteria
C1P65_RS15845	COG0625	glutathione transferase activity
C1P65_RS15850	COG2969	positive regulation of protein catabolic process
C1P65_RS15890	COG2731	YhcH YjgK YiaL family protein
C1P65_RS15895	COG4804	nuclease activity
C1P65_RS15900	COG0493	'glutamate synthase
C1P65_RS15905	COG0069	glutamate synthase activity
C1P65_RS15905	COG0067	glutamate synthase
C1P65_RS15905	COG0070	glutamate synthase
C1P65_RS15910	COG1242	4 iron, 4 sulfur cluster binding
C1P65_RS15915	COG2198	Histidine kinase
C1P65_RS15915	COG0784	Response regulator, receiver
C1P65_RS15915	COG5002	protein histidine kinase activity
C1P65_RS15930	COG0515	serine threonine protein kinase
C1P65_RS15935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS15950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1P65_RS15955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1P65_RS15960	COG1137	ATPase activity
C1P65_RS15965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1P65_RS15970	COG3117	lipopolysaccharide transmembrane transporter activity
C1P65_RS15975	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1P65_RS15985	COG0530	calcium, potassium:sodium antiporter activity
C1P65_RS15990	COG1127	ABC transporter
C1P65_RS15995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1P65_RS16005	COG2854	intermembrane phospholipid transfer
C1P65_RS16010	COG3113	response to antibiotic
C1P65_RS16015	COG5007	Belongs to the BolA IbaG family
C1P65_RS16025	COG3423	Transcriptional regulator
C1P65_RS16030	COG0142	geranyltranstransferase activity
C1P65_RS16045	COG0697	spore germination
C1P65_RS16055	COG2027	D-alanyl-D-alanine carboxypeptidase
C1P65_RS16060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1P65_RS16065	COG1534	Rna-binding protein
C1P65_RS16075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1P65_RS16080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1P65_RS16090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1P65_RS16105	COG2194	sulfuric ester hydrolase activity
C1P65_RS16125	COG0195	Participates in both transcription termination and antitermination
C1P65_RS16165	COG0513	Belongs to the DEAD box helicase family
C1P65_RS16170	COG0814	amino acid
C1P65_RS16175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1P65_RS16180	COG0826	peptidase U32
C1P65_RS16185	COG0826	peptidase U32
C1P65_RS16190	COG3154	lipid carrier protein
C1P65_RS16195	COG3153	acetyltransferase
C1P65_RS16210	COG0693	protein deglycase activity
C1P65_RS16215	COG0702	epimerase
C1P65_RS16225	COG2823	Periplasmic or secreted lipoprotein
C1P65_RS16245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1P65_RS16250	COG3539	Fimbrial protein
C1P65_RS16270	COG2084	Dehydrogenase
C1P65_RS16275	COG1929	Belongs to the glycerate kinase type-1 family
C1P65_RS16330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1P65_RS16340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1P65_RS16345	COG1882	Formate acetyltransferase
C1P65_RS16355	COG1760	l-serine dehydratase
C1P65_RS16370	COG0814	amino acid
C1P65_RS16385	COG1741	Belongs to the pirin family
C1P65_RS16390	COG0583	DNA-binding transcription factor activity
C1P65_RS16420	COG3152	Membrane
C1P65_RS16425	COG0435	Glutathione S-transferase
C1P65_RS16430	COG2259	Doxx family
C1P65_RS16445	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C1P65_RS16450	COG4575	ribosome binding
C1P65_RS16455	COG1422	Protein of unknown function (DUF1090)
C1P65_RS16465	COG0586	Pfam SNARE associated Golgi protein
C1P65_RS16470	COG2186	Transcriptional regulator
C1P65_RS16480	COG2271	Major facilitator Superfamily
C1P65_RS16490	COG2721	sulfolactate sulfo-lyase activity
C1P65_RS16505	COG0861	Integral membrane protein TerC family
C1P65_RS16510	COG0673	inositol 2-dehydrogenase activity
C1P65_RS16525	COG1451	nucleotide metabolic process
C1P65_RS16540	COG5499	transcription regulator containing HTH domain
C1P65_RS16545	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1P65_RS16545	COG1902	pentaerythritol trinitrate reductase activity
C1P65_RS16555	COG3408	Glycogen debranching enzyme
C1P65_RS16555	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1P65_RS16585	COG1609	Transcriptional regulator
C1P65_RS16590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1P65_RS16600	COG0840	transmembrane signaling receptor activity
C1P65_RS16605	COG1695	Transcriptional regulator
C1P65_RS16610	COG2375	cellular response to nickel ion
C1P65_RS16625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1P65_RS16630	COG0358	DNA primase activity
C1P65_RS16635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1P65_RS16675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1P65_RS16690	COG4991	sh3 domain protein
C1P65_RS16695	COG3025	triphosphatase activity
C1P65_RS16775	COG4238	major outer membrane lipoprotein
C1P65_RS16790	COG0204	Acyl-transferase
C1P65_RS16795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1P65_RS16800	COG4166	transmembrane transport
C1P65_RS16805	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C1P65_RS16810	COG3111	PFAM Bacterial OB fold (BOF) protein
C1P65_RS16815	COG0745	RESPONSE REGULATOR receiver
C1P65_RS16820	COG0642	Histidine kinase
C1P65_RS16825	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1P65_RS16830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C1P65_RS16835	COG0187	DNA topoisomerase II activity
C1P65_RS16840	COG3150	esterase
C1P65_RS16845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1P65_RS16850	COG3151	Protein conserved in bacteria
C1P65_RS16855	COG0494	nUDIX hydrolase
C1P65_RS16860	COG1538	Outer membrane efflux protein
C1P65_RS16870	COG0754	glutathionylspermidine amidase activity
C1P65_RS16930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1P65_RS16935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1P65_RS16940	COG4974	Belongs to the 'phage' integrase family
C1P65_RS16945	COG0716	FMN binding
C1P65_RS16955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1P65_RS17010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1P65_RS17015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1P65_RS17020	COG0006	proline dipeptidase activity
C1P65_RS17040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1P65_RS17050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1P65_RS17085	COG1703	isobutyryl-CoA mutase activity
C1P65_RS17105	COG2968	Membrane
C1P65_RS17110	COG1279	arginine transmembrane transporter activity
C1P65_RS17115	COG0668	transmembrane transport
C1P65_RS17120	COG0191	fructose-bisphosphate aldolase activity
C1P65_RS17155	COG1122	ATPase activity
C1P65_RS17160	COG1072	(Pantothenic acid kinase))
C1P65_RS17175	COG1063	alcohol dehydrogenase
C1P65_RS17180	COG2213	PTS system mannitol-specific
C1P65_RS17185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS17200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1P65_RS17205	COG0501	Belongs to the peptidase M48B family
C1P65_RS17235	COG1166	arginine decarboxylase activity
C1P65_RS17260	COG2814	Major facilitator Superfamily
C1P65_RS17270	COG2356	endonuclease I
C1P65_RS17275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1P65_RS17280	COG0189	ligase activity
C1P65_RS17295	COG2805	Type II/IV secretion system protein
C1P65_RS17300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1P65_RS17305	COG0762	integral membrane protein
C1P65_RS17320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1P65_RS17330	COG0252	asparaginase activity
C1P65_RS17340	COG3171	Protein conserved in bacteria
C1P65_RS17350	COG1194	a g-specific adenine glycosylase
C1P65_RS17365	COG2211	Major facilitator Superfamily
C1P65_RS17370	COG1982	Orn Lys Arg decarboxylase major
C1P65_RS17425	COG2165	general secretion pathway protein
C1P65_RS17430	COG1459	type II secretion system
C1P65_RS17435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1P65_RS17455	COG0318	PFAM AMP-dependent synthetase and ligase
C1P65_RS17470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1P65_RS17475	COG0306	phosphate transporter
C1P65_RS17480	COG0754	glutathionylspermidine amidase activity
C1P65_RS17485	COG0625	glutathione transferase activity
C1P65_RS17490	COG0298	carbon dioxide binding
C1P65_RS17500	COG1773	rubredoxin
C1P65_RS17505	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1P65_RS17510	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1P65_RS17515	COG5557	Pfam Polysulphide reductase, NrfD
C1P65_RS17520	COG0437	4 iron, 4 sulfur cluster binding
C1P65_RS17525	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C1P65_RS17565	COG0848	biopolymer transport protein
C1P65_RS17570	COG0811	peptide transport
C1P65_RS17575	COG0626	cystathionine gamma-synthase activity
C1P65_RS17580	COG0586	Pfam SNARE associated Golgi protein
C1P65_RS17585	COG2207	Transcriptional regulator
C1P65_RS17590	COG1979	alcohol dehydrogenase
C1P65_RS17595	COG0656	L-ascorbic acid biosynthetic process
C1P65_RS17615	COG1794	racemase activity, acting on amino acids and derivatives
C1P65_RS17620	COG0583	DNA-binding transcription factor activity
C1P65_RS17630	COG1609	Transcriptional regulator
C1P65_RS17645	COG0667	Aldo Keto reductase
C1P65_RS17655	COG0861	Integral membrane protein TerC family
C1P65_RS17675	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C1P65_RS17690	COG2165	general secretion pathway protein
C1P65_RS17695	COG4795	General secretion pathway protein
C1P65_RS17705	COG4967	type IV pilus modification protein PilV
C1P65_RS17710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1P65_RS17715	COG1025	Belongs to the peptidase M16 family
C1P65_RS17720	COG1074	ATP-dependent DNA helicase activity
C1P65_RS17725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1P65_RS17730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1P65_RS17730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1P65_RS17735	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1P65_RS17750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1P65_RS17755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1P65_RS17760	COG2166	iron-sulfur cluster assembly
C1P65_RS17765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1P65_RS17775	COG0583	DNA-binding transcription factor activity
C1P65_RS17780	COG2363	Small membrane protein
C1P65_RS17790	COG1349	DNA-binding transcription factor activity
C1P65_RS17800	COG1070	Carbohydrate kinase
C1P65_RS17820	COG0235	Class ii aldolase
C1P65_RS17825	COG1454	alcohol dehydrogenase
C1P65_RS17835	COG1760	l-serine dehydratase
C1P65_RS17840	COG0814	amino acid
C1P65_RS17845	COG1611	Belongs to the LOG family
C1P65_RS17860	COG3098	single-species biofilm formation
C1P65_RS17865	COG0564	pseudouridine synthase activity
C1P65_RS17870	COG0716	FMN binding
C1P65_RS17895	COG3437	response regulator, receiver
C1P65_RS17895	COG2205	protein histidine kinase activity
C1P65_RS17895	COG4999	Histidine kinase
C1P65_RS17895	COG3850	Histidine kinase
C1P65_RS17905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1P65_RS17910	COG2336	PFAM SpoVT AbrB
C1P65_RS17915	COG2337	Toxic component of a toxin-antitoxin (TA) module
C1P65_RS17920	COG3956	TIGRFAM MazG family protein
C1P65_RS17990	COG0602	queuosine metabolic process
C1P65_RS18000	COG1070	Carbohydrate kinase
C1P65_RS18010	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS18025	COG0277	FAD linked oxidase domain protein
C1P65_RS18030	COG0477	Major facilitator Superfamily
C1P65_RS18045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C1P65_RS18050	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C1P65_RS18055	COG0644	oxidoreductase
C1P65_RS18060	COG0720	synthase
C1P65_RS18110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1P65_RS18115	COG2234	aminopeptidase activity
C1P65_RS18170	COG4942	peptidase
C1P65_RS18170	COG1388	LysM domain
C1P65_RS18190	COG0163	prenyltransferase activity
C1P65_RS18240	COG0309	Hydrogenase expression formation protein (HypE)
C1P65_RS18245	COG0409	Hydrogenase expression formation protein
C1P65_RS18250	COG0298	carbon dioxide binding
C1P65_RS18255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1P65_RS18260	COG0375	protein maturation
C1P65_RS18275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1P65_RS18290	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C1P65_RS18290	COG3261	NADH dehydrogenase
C1P65_RS18295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1P65_RS18310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1P65_RS18320	COG5499	transcription regulator containing HTH domain
C1P65_RS18325	COG2723	6-phospho-beta-galactosidase activity
C1P65_RS18335	COG1609	Transcriptional regulator
C1P65_RS18345	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1P65_RS18365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1P65_RS18365	COG0517	IMP dehydrogenase activity
C1P65_RS18370	COG1349	DNA-binding transcription factor activity
C1P65_RS18375	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS18380	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS18410	COG3730	PTS system glucitol sorbitol-specific
C1P65_RS18415	COG2951	lytic endotransglycosylase activity
C1P65_RS18420	COG1546	Belongs to the CinA family
C1P65_RS18440	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1P65_RS18470	COG1238	metal cluster binding
C1P65_RS18500	COG1566	PFAM secretion protein HlyD family protein
C1P65_RS18505	COG1846	Transcriptional regulator
C1P65_RS18515	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C1P65_RS18520	COG2814	Major facilitator Superfamily
C1P65_RS18535	COG4176	ABC-type proline glycine betaine transport system permease component
C1P65_RS18540	COG4175	Glycine betaine
C1P65_RS18550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1P65_RS18565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1P65_RS18570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1P65_RS18580	COG4575	ribosome binding
C1P65_RS18600	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1P65_RS18605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1P65_RS18610	COG0640	Transcriptional regulator
C1P65_RS18615	COG0401	homolog of Blt101
C1P65_RS18620	COG1652	LysM domain
C1P65_RS18625	COG1802	Transcriptional regulator
C1P65_RS18630	COG1113	amino acid transport
C1P65_RS18695	COG3436	PFAM IS66 Orf2 family protein
C1P65_RS18710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1P65_RS18715	COG0564	pseudouridine synthase activity
C1P65_RS18725	COG0542	response to heat
C1P65_RS18750	COG0477	Major facilitator Superfamily
C1P65_RS18755	COG5544	Lipoprotein
C1P65_RS18760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1P65_RS18765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1P65_RS18765	COG1042	CoA-binding domain protein
C1P65_RS18765	COG0045	succinate-CoA ligase (ADP-forming) activity
C1P65_RS18770	COG3148	PFAM DTW domain containing protein
C1P65_RS18775	COG3118	belongs to the thioredoxin family
C1P65_RS18780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1P65_RS18820	COG0583	DNA-binding transcription factor activity
C1P65_RS18825	COG0513	Belongs to the DEAD box helicase family
C1P65_RS18835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1P65_RS18845	COG1595	DNA-templated transcription, initiation
C1P65_RS18850	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C1P65_RS18855	COG3026	antisigma factor binding
C1P65_RS18860	COG3086	response to oxidative stress
C1P65_RS18870	COG0681	Belongs to the peptidase S26 family
C1P65_RS18925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1P65_RS18975	COG2867	negative regulation of translational initiation
C1P65_RS18985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1P65_RS18990	COG0497	DNA recombination
C1P65_RS19010	COG4536	flavin adenine dinucleotide binding
C1P65_RS19015	COG4137	Cytochrome C assembly protein
C1P65_RS19020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1P65_RS19100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1P65_RS19105	COG0077	Prephenate dehydratase
C1P65_RS19105	COG1605	Chorismate mutase
C1P65_RS19110	COG0287	Prephenate dehydrogenase
C1P65_RS19110	COG1605	Chorismate mutase
C1P65_RS19115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1P65_RS19180	COG1737	Transcriptional regulator
C1P65_RS19185	COG0560	Phosphoserine phosphatase
C1P65_RS19190	COG0590	tRNA wobble adenosine to inosine editing
C1P65_RS19205	COG2205	protein histidine kinase activity
C1P65_RS19210	COG3170	Tfp pilus assembly protein FimV
C1P65_RS19215	COG2204	response regulator
C1P65_RS19220	COG0347	Belongs to the P(II) protein family
C1P65_RS19225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1P65_RS19225	COG1017	nitric oxide dioxygenase activity
C1P65_RS19235	COG1940	carbohydrate kinase activity
C1P65_RS19260	COG0583	DNA-binding transcription factor activity
C1P65_RS19265	COG2814	Major facilitator Superfamily
C1P65_RS19270	COG3711	transcriptional antiterminator
C1P65_RS19275	COG1073	alpha beta
C1P65_RS19280	COG0483	inositol monophosphate 1-phosphatase activity
C1P65_RS19300	COG0822	iron-sulfur transferase activity
C1P65_RS19320	COG0633	Ferredoxin
C1P65_RS19325	COG2975	iron-sulfur cluster assembly
C1P65_RS19340	COG2897	thiosulfate sulfurtransferase activity
C1P65_RS19350	COG4953	penicillin-binding protein 1C
C1P65_RS19380	COG2976	Protein conserved in bacteria
C1P65_RS19395	COG1645	bacterial-type flagellum-dependent swarming motility
C1P65_RS19405	COG0517	IMP dehydrogenase activity
C1P65_RS19405	COG0516	GMP reductase activity
C1P65_RS19425	COG3133	Outer membrane lipoprotein
C1P65_RS19465	COG0248	Ppx GppA phosphatase
C1P65_RS19470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1P65_RS19475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1P65_RS19490	COG2233	PERMEase
C1P65_RS19500	COG1393	Belongs to the ArsC family
C1P65_RS19505	COG4783	chaperone-mediated protein folding
C1P65_RS19510	COG0628	permease
C1P65_RS19515	COG2116	formate transmembrane transporter activity
C1P65_RS19530	COG3260	NADH ubiquinone oxidoreductase 20
C1P65_RS19540	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C1P65_RS19540	COG3261	NADH dehydrogenase
C1P65_RS19545	COG0651	ATP synthesis coupled electron transport
C1P65_RS19550	COG4237	Hydrogenase 4 membrane
C1P65_RS19560	COG0650	Formate hydrogenlyase subunit 4
C1P65_RS19565	COG0651	ATP synthesis coupled electron transport
C1P65_RS19570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1P65_RS19575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1P65_RS19580	COG2716	regulation of RNA biosynthetic process
C1P65_RS19590	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1P65_RS19605	COG1444	tRNA N-acetyltransferase activity
C1P65_RS19635	COG1393	Belongs to the ArsC family
C1P65_RS19655	COG3850	Histidine kinase
C1P65_RS19665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1P65_RS19665	COG0493	'glutamate synthase
C1P65_RS19675	COG5342	invasion associated locus B
C1P65_RS19705	COG0281	malic enzyme
C1P65_RS19705	COG0280	phosphate acetyltransferase
C1P65_RS19740	COG4816	utilization protein
C1P65_RS19745	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C1P65_RS19750	COG2207	Transcriptional regulator
C1P65_RS19760	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1P65_RS19780	COG2837	iron assimilation
C1P65_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS19825	COG4150	thiosulfate binding
C1P65_RS19830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1P65_RS19835	COG4208	sulfate ABC transporter
C1P65_RS19840	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1P65_RS19845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1P65_RS19860	COG2190	(PTS) system
C1P65_RS19865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1P65_RS19870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS19875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1P65_RS19895	COG3530	Putative quorum-sensing-regulated virulence factor
C1P65_RS19900	COG0385	Bile acid
C1P65_RS19950	COG0675	Transposase, IS605 OrfB family
C1P65_RS19955	COG3415	Transposase
C1P65_RS19960	COG3415	Transposase
C1P65_RS19975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1P65_RS20005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1P65_RS20010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1P65_RS20020	COG1363	Peptidase, m42
C1P65_RS20045	COG3275	phosphorelay sensor kinase activity
C1P65_RS20050	COG0436	Aminotransferase
C1P65_RS20060	COG1560	Kdo2-lipid A biosynthetic process
C1P65_RS20085	COG0028	Belongs to the TPP enzyme family
C1P65_RS20090	COG0679	Auxin Efflux Carrier
C1P65_RS20095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1P65_RS20140	COG1566	PFAM secretion protein HlyD family protein
C1P65_RS20145	COG0477	Major facilitator Superfamily
C1P65_RS20205	COG2116	formate transmembrane transporter activity
C1P65_RS20210	COG2853	Lipoprotein
C1P65_RS20225	COG2067	long-chain fatty acid transport protein
C1P65_RS20230	COG3691	Protein conserved in bacteria
C1P65_RS20245	COG2062	phosphohistidine phosphatase, SixA
C1P65_RS20260	COG3539	Fimbrial protein
C1P65_RS20270	COG3121	Chaperone
C1P65_RS20275	COG3539	Fimbrial protein
C1P65_RS20280	COG3539	Fimbrial protein
C1P65_RS20285	COG3539	Fimbrial protein
C1P65_RS20315	COG0730	response to heat
C1P65_RS20320	COG3101	peptidyl-lysine hydroxylation
C1P65_RS20335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1P65_RS20355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1P65_RS20365	COG0586	Pfam SNARE associated Golgi protein
C1P65_RS20375	COG0285	dihydrofolate synthase activity
C1P65_RS20380	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1P65_RS20385	COG1286	toxin biosynthetic process
C1P65_RS20390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1P65_RS20395	COG0163	prenyltransferase activity
C1P65_RS20400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1P65_RS20405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1P65_RS20410	COG4215	(ABC) transporter
C1P65_RS20415	COG4160	amino acid transport
C1P65_RS20420	COG4598	ABC transporter
C1P65_RS20440	COG1090	epimerase
C1P65_RS20445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1P65_RS20450	COG0625	glutathione transferase activity
C1P65_RS20455	COG0625	glutathione transferase activity
C1P65_RS20460	COG0625	glutathione transferase activity
C1P65_RS20465	COG0622	Phosphoesterase
C1P65_RS20470	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1P65_RS20475	COG1288	antiporter activity
C1P65_RS20480	COG0857	belongs to the CobB CobQ family
C1P65_RS20480	COG0280	phosphate acetyltransferase
C1P65_RS20485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1P65_RS20500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1P65_RS20505	COG0471	metal ion transport
C1P65_RS20505	COG0490	domain, Protein
C1P65_RS20515	COG0436	Aminotransferase
C1P65_RS20520	COG0583	DNA-binding transcription factor activity
C1P65_RS20540	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C1P65_RS20545	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1P65_RS20550	COG1034	ATP synthesis coupled electron transport
C1P65_RS20565	COG0839	Belongs to the complex I subunit 6 family
C1P65_RS20575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1P65_RS20580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1P65_RS20615	COG2153	protein acetylation
C1P65_RS20620	COG4575	ribosome binding
C1P65_RS20625	COG1169	isochorismate synthase
C1P65_RS20640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1P65_RS20650	COG0318	PFAM AMP-dependent synthetase and ligase
C1P65_RS20705	COG1414	Transcriptional regulator
C1P65_RS20735	COG2271	Major facilitator Superfamily
C1P65_RS20740	COG2271	Major facilitator Superfamily
C1P65_RS20750	COG5464	transposase or invertase
C1P65_RS20755	COG0247	lactate metabolic process
C1P65_RS20765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1P65_RS20770	COG2271	Major facilitator Superfamily
C1P65_RS20775	COG0584	glycerophosphoryl diester phosphodiesterase
C1P65_RS20785	COG2814	Major facilitator Superfamily
C1P65_RS20795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1P65_RS20800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1P65_RS20805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1P65_RS20820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1P65_RS20825	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
C1P65_RS20825	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
C1P65_RS20830	COG3234	Protein of unknown function (DUF1175)
C1P65_RS20835	COG0582	viral genome integration into host DNA
C1P65_RS20860	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C1P65_RS20895	COG4160	amino acid transport
C1P65_RS20900	COG4215	(ABC) transporter
C1P65_RS20905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1P65_RS20910	COG1126	abc transporter atp-binding protein
C1P65_RS20980	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1P65_RS20985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1P65_RS20990	COG0702	epimerase
C1P65_RS20995	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C1P65_RS21000	COG0028	Belongs to the TPP enzyme family
C1P65_RS21005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1P65_RS21015	COG2431	L-lysine efflux transmembrane transporter activity
C1P65_RS21030	COG3593	DNA synthesis involved in DNA repair
C1P65_RS21035	COG2990	Protein conserved in bacteria
C1P65_RS21040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1P65_RS21050	COG1278	Cold shock
C1P65_RS21060	COG0542	response to heat
C1P65_RS21085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1P65_RS21090	COG4988	ABC transporter
C1P65_RS21095	COG0492	ferredoxin-NADP+ reductase activity
C1P65_RS21100	COG1522	sequence-specific DNA binding
C1P65_RS21105	COG1178	ABC-type Fe3 transport system permease component
C1P65_RS21105	COG1674	ftsk spoiiie
C1P65_RS21115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1P65_RS21125	COG0243	molybdopterin cofactor binding
C1P65_RS21135	COG3302	dmso reductase anchor subunit
C1P65_RS21140	COG1335	isochorismatase
C1P65_RS21145	COG1335	isochorismatase
C1P65_RS21155	COG0531	amino acid
C1P65_RS21180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1P65_RS21185	COG1882	Formate acetyltransferase
C1P65_RS21190	COG2116	formate transmembrane transporter activity
C1P65_RS21195	COG1944	ATP diphosphatase activity
C1P65_RS21200	COG2323	membrane
C1P65_RS21225	COG0501	Belongs to the peptidase M48B family
C1P65_RS21235	COG0539	negative regulation of cytoplasmic translation
C1P65_RS21245	COG2333	competence protein COMEC
C1P65_RS21245	COG0658	competence protein
C1P65_RS21250	COG1132	(ABC) transporter
C1P65_RS21260	COG3214	Protein conserved in bacteria
C1P65_RS21275	COG3173	Aminoglycoside phosphotransferase
C1P65_RS21280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1P65_RS21285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1P65_RS21295	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1P65_RS21310	COG2989	Protein conserved in bacteria
C1P65_RS21315	COG3108	Peptidase M15
C1P65_RS21320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1P65_RS21345	COG0308	aminopeptidase N
C1P65_RS21350	COG1116	anion transmembrane transporter activity
C1P65_RS21355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1P65_RS21365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1P65_RS21370	COG0431	NADPH-dependent FMN reductase
C1P65_RS21385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS21385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS21390	COG1105	Belongs to the carbohydrate kinase PfkB family
C1P65_RS21395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1P65_RS21395	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1P65_RS21395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1P65_RS21410	COG3038	cytochrome b561
C1P65_RS21445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1P65_RS21460	COG2943	transferase activity, transferring hexosyl groups
C1P65_RS21465	COG5645	(Lipo)protein
C1P65_RS21495	COG1560	Kdo2-lipid A biosynthetic process
C1P65_RS21515	COG0745	RESPONSE REGULATOR receiver
C1P65_RS21520	COG2205	protein histidine kinase activity
C1P65_RS21530	COG3547	Transposase (IS116 IS110 IS902 family)
C1P65_RS21540	COG0631	protein serine/threonine phosphatase activity
C1P65_RS21545	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C1P65_RS21550	COG0443	Heat shock 70 kDa protein
C1P65_RS21555	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C1P65_RS21565	COG0572	uridine kinase
C1P65_RS21575	COG2982	Protein involved in outer membrane biogenesis
C1P65_RS21590	COG1253	flavin adenine dinucleotide binding
C1P65_RS21600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1P65_RS21605	COG1088	dTDP-glucose 4,6-dehydratase activity
C1P65_RS21610	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1P65_RS21650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1P65_RS21655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1P65_RS21685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1P65_RS21690	COG0131	Imidazoleglycerol-phosphate dehydratase
C1P65_RS21690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1P65_RS21715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1P65_RS21730	COG0531	amino acid
C1P65_RS21745	COG2391	methyltransferase activity
C1P65_RS21750	COG0425	Belongs to the sulfur carrier protein TusA family
C1P65_RS21755	COG2925	Exonuclease
C1P65_RS21765	COG1686	Belongs to the peptidase S11 family
C1P65_RS21790	COG1289	transmembrane transporter activity
C1P65_RS21800	COG4917	ethanolamine utilization protein
C1P65_RS21825	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C1P65_RS21840	COG1376	ErfK ybiS ycfS ynhG family protein
C1P65_RS21850	COG0583	DNA-binding transcription factor activity
C1P65_RS21855	COG0583	DNA-binding transcription factor activity
C1P65_RS21900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1P65_RS21905	COG0477	Major facilitator Superfamily
C1P65_RS21920	COG3609	addiction module antidote protein, CC2985 family
C1P65_RS21930	COG0826	peptidase U32
C1P65_RS21950	COG1063	alcohol dehydrogenase
C1P65_RS21960	COG3414	Phosphotransferase system galactitol-specific IIB component
C1P65_RS21995	COG1830	Aldolase
C1P65_RS22000	COG2211	Major facilitator Superfamily
C1P65_RS22005	COG1397	ADP-ribosylglycohydrolase
C1P65_RS22010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1P65_RS22015	COG2188	Transcriptional regulator
C1P65_RS22025	COG0351	phosphomethylpyrimidine kinase
C1P65_RS22045	COG5455	response to cobalt ion
C1P65_RS22070	COG3188	usher protein
C1P65_RS22090	COG0489	protein tyrosine kinase activity
C1P65_RS22130	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C1P65_RS22150	COG4808	Protein conserved in bacteria
C1P65_RS22155	COG4807	Protein conserved in bacteria
C1P65_RS22160	COG3279	Response regulator of the LytR AlgR family
C1P65_RS22165	COG3275	phosphorelay sensor kinase activity
C1P65_RS22170	COG0789	Transcriptional regulator
C1P65_RS22180	COG1174	glycine betaine transport
C1P65_RS22195	COG1732	Glycine betaine
C1P65_RS22200	COG1472	Belongs to the glycosyl hydrolase 3 family
C1P65_RS22205	COG0277	FAD linked oxidase domain protein
C1P65_RS22210	COG1686	Belongs to the peptidase S11 family
C1P65_RS22220	COG0586	Pfam SNARE associated Golgi protein
C1P65_RS22225	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS22255	COG1346	cytolysis
C1P65_RS22265	COG2949	membrane
C1P65_RS22290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1P65_RS22290	COG0167	dihydroorotate dehydrogenase activity
C1P65_RS22305	COG1129	ABC transporter
C1P65_RS22335	COG1879	ABC-type sugar transport system periplasmic component
C1P65_RS22340	COG1609	Transcriptional regulator
C1P65_RS22385	COG4771	TonB-dependent receptor
C1P65_RS22395	COG0833	amino acid
C1P65_RS22400	COG0583	DNA-binding transcription factor activity
C1P65_RS22405	COG2855	membrane
C1P65_RS22415	COG1522	sequence-specific DNA binding
C1P65_RS22415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1P65_RS22420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1P65_RS22445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1P65_RS22495	COG2999	glutathione oxidoreductase activity
C1P65_RS22515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1P65_RS22525	COG0673	inositol 2-dehydrogenase activity
C1P65_RS22530	COG0728	peptidoglycan biosynthetic process
C1P65_RS22540	COG2747	anti-sigma28 factor FlgM
C1P65_RS22545	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C1P65_RS22560	COG1815	bacterial-type flagellum-dependent cell motility
C1P65_RS22565	COG1558	bacterial-type flagellum-dependent cell motility
C1P65_RS22570	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C1P65_RS22575	COG1749	Flagellar hook protein flgE
C1P65_RS22600	COG1705	Flagellar rod assembly protein muramidase FlgJ
C1P65_RS22600	COG3951	Flagellar rod assembly protein muramidase FlgJ
C1P65_RS22610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1P65_RS22615	COG1530	ribonuclease E activity
C1P65_RS22625	COG0564	pseudouridine synthase activity
C1P65_RS22650	COG1399	metal-binding, possibly nucleic acid-binding protein
C1P65_RS22670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1P65_RS22675	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS22685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1P65_RS22690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1P65_RS22695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1P65_RS22705	COG0470	DNA polymerase III
C1P65_RS22710	COG0084	hydrolase, TatD family'
C1P65_RS22715	COG1263	PTS System
C1P65_RS22715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1P65_RS22720	COG4773	Receptor
C1P65_RS22725	COG0537	adenosine 5'-monophosphoramidase activity
C1P65_RS22730	COG5633	Lipoprotein
C1P65_RS22735	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C1P65_RS22755	COG1252	NADH dehydrogenase
C1P65_RS22760	COG3134	Outer membrane lipoprotein
C1P65_RS22765	COG1309	transcriptional regulator
C1P65_RS22775	COG1376	ErfK ybiS ycfS ynhG family protein
C1P65_RS22775	COG1388	LysM domain
C1P65_RS22785	COG4763	Acyl-transferase
C1P65_RS22790	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1P65_RS22800	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1P65_RS22810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1P65_RS22815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1P65_RS22820	COG1177	transmembrane transport
C1P65_RS22840	COG2850	peptidyl-arginine hydroxylation
C1P65_RS22845	COG2205	protein histidine kinase activity
C1P65_RS22855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1P65_RS22875	COG1187	pseudouridine synthase activity
C1P65_RS22880	COG0538	isocitrate dehydrogenase activity
C1P65_RS22975	COG3772	lysozyme
C1P65_RS23015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1P65_RS23035	COG3008	intermembrane lipid transfer
C1P65_RS23055	COG1956	GAF domain-containing protein
C1P65_RS23065	COG0793	Belongs to the peptidase S41A family
C1P65_RS23080	COG1414	Transcriptional regulator
C1P65_RS23115	COG2226	methyltransferase
C1P65_RS23130	COG3716	PTS system mannose fructose sorbose family IID component
C1P65_RS23135	COG3715	PTS system
C1P65_RS23140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1P65_RS23140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1P65_RS23145	COG1253	flavin adenine dinucleotide binding
C1P65_RS23180	COG3391	amine dehydrogenase activity
C1P65_RS23185	COG1113	amino acid transport
C1P65_RS23190	COG0625	glutathione transferase activity
C1P65_RS23235	COG1396	sequence-specific DNA binding
C1P65_RS23235	COG1917	Cupin 2, conserved barrel domain protein
C1P65_RS23245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1P65_RS23255	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1P65_RS23260	COG1842	Phage shock protein A
C1P65_RS23270	COG1983	PspC domain protein
C1P65_RS23280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1P65_RS23385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1P65_RS23405	COG0396	ATPase activity
C1P65_RS23410	COG0719	Fe-S assembly protein
C1P65_RS23425	COG1376	ErfK ybiS ycfS ynhG family protein
C1P65_RS23430	COG4238	major outer membrane lipoprotein
C1P65_RS23440	COG0469	pyruvate kinase activity
C1P65_RS23465	COG0437	4 iron, 4 sulfur cluster binding
C1P65_RS23470	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C1P65_RS23505	COG3468	outer membrane autotransporter barrel domain protein
C1P65_RS23525	COG0307	riboflavin synthase, alpha
C1P65_RS23530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1P65_RS23535	COG2814	Major facilitator Superfamily
C1P65_RS23540	COG0583	DNA-binding transcription factor activity
C1P65_RS23555	COG2814	Major facilitator Superfamily
C1P65_RS23560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1P65_RS23565	COG0791	NLP P60 protein
C1P65_RS23570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1P65_RS23585	COG0346	lactoylglutathione lyase activity
C1P65_RS23590	COG1902	pentaerythritol trinitrate reductase activity
C1P65_RS23605	COG1309	transcriptional regulator
C1P65_RS23610	COG3313	Fe-S protein
C1P65_RS23615	COG4989	oxidoreductase activity
C1P65_RS23620	COG2032	superoxide dismutase activity
C1P65_RS23630	COG1566	PFAM secretion protein HlyD family protein
C1P65_RS23645	COG3133	Outer membrane lipoprotein
C1P65_RS23655	COG3895	Periplasmic Protein
C1P65_RS23675	COG0625	glutathione transferase activity
C1P65_RS23680	COG3104	oligopeptide transport
C1P65_RS23685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1P65_RS23695	COG4659	FMN binding
C1P65_RS23745	COG0673	inositol 2-dehydrogenase activity
C1P65_RS23755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1P65_RS23775	COG1263	PTS System
C1P65_RS23775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1P65_RS23780	COG1609	Transcriptional regulator
C1P65_RS23790	COG1028	Short-chain dehydrogenase reductase Sdr
C1P65_RS23795	COG1309	transcriptional regulator
C1P65_RS23825	COG5339	Protein conserved in bacteria
C1P65_RS23830	COG1482	cell wall glycoprotein biosynthetic process
C1P65_RS23835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C1P65_RS23835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C1P65_RS23840	COG0114	fumarate hydratase activity
C1P65_RS23850	COG2205	protein histidine kinase activity
C1P65_RS23855	COG0745	RESPONSE REGULATOR receiver
C1P65_RS24045	COG3436	PFAM IS66 Orf2 family protein
C1P65_RS24155	COG3344	reverse transcriptase
C1P65_RS24365	COG0297	glycogen (starch) synthase activity
C1P65_RS24370	COG2990	Protein conserved in bacteria
C1P65_RS24430	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1P65_RS24675	COG3547	Transposase (IS116 IS110 IS902 family)