locus-tag	class	description
C3L21_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C3L21_RS00010	COG0424	maF-like protein
C3L21_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3L21_RS00020	COG0237	dephospho-CoA kinase activity
C3L21_RS00025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3L21_RS00030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C3L21_RS00060	COG0187	DNA topoisomerase II activity
C3L21_RS00080	COG1802	Transcriptional regulator
C3L21_RS00085	COG2721	sulfolactate sulfo-lyase activity
C3L21_RS00105	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS00110	COG1063	alcohol dehydrogenase
C3L21_RS00130	COG0135	phosphoribosylanthranilate isomerase activity
C3L21_RS00135	COG0133	tryptophan synthase activity
C3L21_RS00140	COG0159	tryptophan synthase activity
C3L21_RS00145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3L21_RS00160	COG1074	ATP-dependent DNA helicase activity
C3L21_RS00165	COG2887	Belongs to the helicase family. UvrD subfamily
C3L21_RS00170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3L21_RS00175	COG3178	'Phosphotransferase
C3L21_RS00180	COG2205	protein histidine kinase activity
C3L21_RS00185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C3L21_RS00195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3L21_RS00195	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3L21_RS00205	COG2205	protein histidine kinase activity
C3L21_RS00210	COG0745	RESPONSE REGULATOR receiver
C3L21_RS00215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C3L21_RS00225	COG1652	LysM domain
C3L21_RS00230	COG3145	DNA-N1-methyladenine dioxygenase activity
C3L21_RS00235	COG1072	(Pantothenic acid kinase))
C3L21_RS00240	COG0140	phosphoribosyl-ATP diphosphatase activity
C3L21_RS00245	COG0107	imidazoleglycerol-phosphate synthase activity
C3L21_RS00250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3L21_RS00255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3L21_RS00265	COG0131	Imidazoleglycerol-phosphate dehydratase
C3L21_RS00270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C3L21_RS00280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C3L21_RS00290	COG2124	cytochrome p450
C3L21_RS00300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3L21_RS00315	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C3L21_RS00325	COG1643	Atp-dependent helicase
C3L21_RS00330	COG4136	ATPase activity
C3L21_RS00335	COG4135	transport system, permease component
C3L21_RS00340	COG4134	Bacterial extracellular solute-binding protein
C3L21_RS00395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3L21_RS00425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3L21_RS00435	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3L21_RS00435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3L21_RS00440	COG4311	Sarcosine oxidase, delta subunit
C3L21_RS00445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS00450	COG4977	sequence-specific DNA binding
C3L21_RS00455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3L21_RS00460	COG2218	PFAM glutamate synthase alpha subunit domain protein
C3L21_RS00465	COG0069	glutamate synthase activity
C3L21_RS00470	COG0174	glutamine synthetase
C3L21_RS00485	COG0531	amino acid
C3L21_RS00515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3L21_RS00540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3L21_RS00550	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C3L21_RS00555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS00565	COG2186	Transcriptional regulator
C3L21_RS00580	COG3842	ATPase activity
C3L21_RS00590	COG0673	inositol 2-dehydrogenase activity
C3L21_RS00595	COG0395	ABC-type sugar transport system, permease component
C3L21_RS00600	COG1175	transmembrane transport
C3L21_RS00605	COG1653	transport
C3L21_RS00610	COG1309	transcriptional regulator
C3L21_RS00615	COG0673	inositol 2-dehydrogenase activity
C3L21_RS00635	COG0673	inositol 2-dehydrogenase activity
C3L21_RS00680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C3L21_RS00685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3L21_RS00690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3L21_RS00695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C3L21_RS00730	COG4964	Belongs to the GSP D family
C3L21_RS00760	COG3385	transposase activity
C3L21_RS00770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3L21_RS00780	COG0791	NLP P60 protein
C3L21_RS00785	COG3385	transposase activity
C3L21_RS00795	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS00800	COG4239	(ABC) transporter, permease
C3L21_RS00805	COG4174	ABC transporter (Permease)
C3L21_RS00810	COG4166	transmembrane transport
C3L21_RS00815	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C3L21_RS00820	COG1803	Methylglyoxal synthase
C3L21_RS00825	COG0837	glucose binding
C3L21_RS00830	COG1132	(ABC) transporter
C3L21_RS00835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3L21_RS00840	COG0588	phosphoglycerate mutase activity
C3L21_RS00845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3L21_RS00870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3L21_RS00890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3L21_RS00890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3L21_RS00905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3L21_RS00925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3L21_RS00930	COG0443	Heat shock 70 kDa protein
C3L21_RS00935	COG0484	heat shock protein binding
C3L21_RS00950	COG0306	phosphate transporter
C3L21_RS00955	COG1392	Phosphate transport regulator
C3L21_RS00960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3L21_RS00980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3L21_RS00985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS00995	COG0673	inositol 2-dehydrogenase activity
C3L21_RS01000	COG0395	ABC-type sugar transport system, permease component
C3L21_RS01005	COG1175	transmembrane transport
C3L21_RS01015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C3L21_RS01020	COG2971	BadF BadG BcrA BcrD
C3L21_RS01030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3L21_RS01035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3L21_RS01040	COG3142	Participates in the control of copper homeostasis
C3L21_RS01045	COG1940	carbohydrate kinase activity
C3L21_RS01060	COG2900	Belongs to the SlyX family
C3L21_RS01070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3L21_RS01095	COG1917	Cupin 2, conserved barrel domain protein
C3L21_RS01095	COG2207	Transcriptional regulator
C3L21_RS01100	COG2814	Major facilitator Superfamily
C3L21_RS01105	COG4771	TonB-dependent receptor
C3L21_RS01115	COG2814	Major facilitator Superfamily
C3L21_RS01135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3L21_RS01140	COG3474	cytochrome
C3L21_RS01145	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C3L21_RS01150	COG0077	Prephenate dehydratase
C3L21_RS01150	COG1605	Chorismate mutase
C3L21_RS01165	COG2378	regulation of single-species biofilm formation
C3L21_RS01170	COG2816	NAD+ diphosphatase activity
C3L21_RS01185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3L21_RS01190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3L21_RS01200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3L21_RS01205	COG2951	lytic endotransglycosylase activity
C3L21_RS01210	COG2814	Major facilitator Superfamily
C3L21_RS01215	COG0779	Required for maturation of 30S ribosomal subunits
C3L21_RS01220	COG0195	Participates in both transcription termination and antitermination
C3L21_RS01220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3L21_RS01230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3L21_RS01235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3L21_RS01240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3L21_RS01250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3L21_RS01255	COG1185	polyribonucleotide nucleotidyltransferase activity
C3L21_RS01265	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3L21_RS01275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3L21_RS01285	COG2860	membrane
C3L21_RS01305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3L21_RS01310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3L21_RS01315	COG0539	negative regulation of cytoplasmic translation
C3L21_RS01320	COG2801	Transposase and inactivated derivatives
C3L21_RS01320	COG3415	Transposase
C3L21_RS01345	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3L21_RS01350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3L21_RS01365	COG3415	Transposase
C3L21_RS01365	COG2801	Transposase and inactivated derivatives
C3L21_RS01385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3L21_RS01395	COG0481	GTPase activity
C3L21_RS01415	COG3932	Exopolysaccharide synthesis, ExoD
C3L21_RS01420	COG2885	chlorophyll binding
C3L21_RS01425	COG1509	lysine 2,3-aminomutase activity
C3L21_RS01430	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C3L21_RS01435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3L21_RS01440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3L21_RS01460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3L21_RS01465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3L21_RS01470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3L21_RS01475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3L21_RS01480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3L21_RS01480	COG0072	phenylalanine-tRNA ligase activity
C3L21_RS01490	COG0667	Aldo Keto reductase
C3L21_RS01515	COG0667	Aldo Keto reductase
C3L21_RS01535	COG1570	exodeoxyribonuclease VII activity
C3L21_RS01540	COG2249	NAD(P)H dehydrogenase (quinone) activity
C3L21_RS01545	COG1846	Transcriptional regulator
C3L21_RS01550	COG0697	spore germination
C3L21_RS01555	COG2309	aminopeptidase activity
C3L21_RS01560	COG0625	glutathione transferase activity
C3L21_RS01575	COG1393	Belongs to the ArsC family
C3L21_RS01580	COG1448	Aminotransferase
C3L21_RS01615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3L21_RS01615	COG0519	Catalyzes the synthesis of GMP from XMP
C3L21_RS01630	COG1247	-acetyltransferase
C3L21_RS01665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C3L21_RS01675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3L21_RS01685	COG1968	undecaprenyl-diphosphatase activity
C3L21_RS01695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS01705	COG0284	orotidine-5'-phosphate decarboxylase activity
C3L21_RS01715	COG3963	phosphatidate phosphatase activity
C3L21_RS01720	COG0592	DNA-directed DNA polymerase activity
C3L21_RS01725	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3L21_RS01730	COG0792	nuclease activity
C3L21_RS01735	COG0189	ligase activity
C3L21_RS01780	COG4584	PFAM Integrase catalytic
C3L21_RS01785	COG1484	DNA-dependent DNA replication
C3L21_RS01800	COG1196	nuclear chromosome segregation
C3L21_RS01815	COG1234	tRNA 3'-trailer cleavage
C3L21_RS01820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3L21_RS01885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3L21_RS01900	COG0697	spore germination
C3L21_RS01910	COG1522	sequence-specific DNA binding
C3L21_RS01915	COG0756	dUTP diphosphatase activity
C3L21_RS01920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3L21_RS01945	COG3718	enzyme involved in inositol metabolism
C3L21_RS01950	COG1082	Xylose isomerase domain protein TIM barrel
C3L21_RS01980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3L21_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS02005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3L21_RS02010	COG2226	methyltransferase
C3L21_RS02015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3L21_RS02020	COG1024	Enoyl-CoA hydratase
C3L21_RS02025	COG0268	Binds directly to 16S ribosomal RNA
C3L21_RS02030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3L21_RS02035	COG3795	YCII-related domain
C3L21_RS02040	COG4941	Belongs to the sigma-70 factor family
C3L21_RS02055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3L21_RS02060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3L21_RS02070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3L21_RS02075	COG1420	regulation of RNA biosynthetic process
C3L21_RS02080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3L21_RS02085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3L21_RS02090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3L21_RS02095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C3L21_RS02100	COG1137	ATPase activity
C3L21_RS02105	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C3L21_RS02115	COG0616	signal peptide processing
C3L21_RS02120	COG0776	regulation of translation
C3L21_RS02135	COG0116	Belongs to the methyltransferase superfamily
C3L21_RS02135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C3L21_RS02140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3L21_RS02145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3L21_RS02150	COG2205	protein histidine kinase activity
C3L21_RS02150	COG0784	Response regulator, receiver
C3L21_RS02150	COG5002	protein histidine kinase activity
C3L21_RS02160	COG0280	phosphate acetyltransferase
C3L21_RS02160	COG0281	malic enzyme
C3L21_RS02165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3L21_RS02170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C3L21_RS02175	COG0728	peptidoglycan biosynthetic process
C3L21_RS02185	COG0180	Tryptophanyl-tRNA synthetase
C3L21_RS02195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C3L21_RS02215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3L21_RS02220	COG1702	phosphate starvation-inducible protein PhoH
C3L21_RS02225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3L21_RS02230	COG4535	Mg2 and Co2 transporter CorC
C3L21_RS02235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3L21_RS02240	COG1396	sequence-specific DNA binding
C3L21_RS02245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3L21_RS02250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3L21_RS02260	COG0071	Belongs to the small heat shock protein (HSP20) family
C3L21_RS02265	COG1957	nucleoside hydrolase
C3L21_RS02270	COG0840	transmembrane signaling receptor activity
C3L21_RS02275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3L21_RS02285	COG0242	peptide deformylase activity
C3L21_RS02290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3L21_RS02295	COG0101	tRNA pseudouridine synthase activity
C3L21_RS02305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3L21_RS02325	COG0583	DNA-binding transcription factor activity
C3L21_RS02335	COG0513	Belongs to the DEAD box helicase family
C3L21_RS02345	COG2171	N-acyltransferase activity
C3L21_RS02365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3L21_RS02365	COG2169	Transcriptional regulator
C3L21_RS02375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3L21_RS02385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3L21_RS02395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C3L21_RS02400	COG0706	membrane insertase activity
C3L21_RS02405	COG0594	ribonuclease P activity
C3L21_RS02410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3L21_RS02430	COG5002	protein histidine kinase activity
C3L21_RS02470	COG1304	FMN binding
C3L21_RS02545	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3L21_RS02555	COG2259	Doxx family
C3L21_RS02585	COG1072	(Pantothenic acid kinase))
C3L21_RS02590	COG0418	dihydroorotase activity
C3L21_RS02595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3L21_RS02605	COG0166	Belongs to the GPI family
C3L21_RS02610	COG0318	PFAM AMP-dependent synthetase and ligase
C3L21_RS02615	COG2814	Major facilitator Superfamily
C3L21_RS02620	COG0628	permease
C3L21_RS02635	COG4589	Belongs to the CDS family
C3L21_RS02660	COG2326	polyphosphate kinase activity
C3L21_RS02665	COG5002	protein histidine kinase activity
C3L21_RS02675	COG0573	inorganic phosphate transmembrane transporter activity
C3L21_RS02685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3L21_RS02690	COG0704	Plays a role in the regulation of phosphate uptake
C3L21_RS02695	COG0745	RESPONSE REGULATOR receiver
C3L21_RS02710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3L21_RS02715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3L21_RS02720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C3L21_RS02725	COG2967	ApaG domain
C3L21_RS02730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3L21_RS02740	COG0717	Belongs to the dCTP deaminase family
C3L21_RS02750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS02770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3L21_RS02775	COG0387	Pfam Sodium calcium exchanger
C3L21_RS02780	COG1733	regulation of RNA biosynthetic process
C3L21_RS02790	COG1024	Enoyl-CoA hydratase
C3L21_RS02790	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3L21_RS02795	COG0183	Belongs to the thiolase family
C3L21_RS02800	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS02810	COG0730	response to heat
C3L21_RS02830	COG1201	RNA secondary structure unwinding
C3L21_RS02835	COG1959	2 iron, 2 sulfur cluster binding
C3L21_RS02840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3L21_RS02865	COG0534	Mate efflux family protein
C3L21_RS02870	COG0167	dihydroorotate dehydrogenase activity
C3L21_RS02895	COG1970	mechanosensitive ion channel activity
C3L21_RS02915	COG1294	oxidase, subunit
C3L21_RS02920	COG1271	oxidase subunit
C3L21_RS02925	COG1473	amidohydrolase
C3L21_RS02935	COG4215	(ABC) transporter
C3L21_RS02940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS02950	COG1309	transcriptional regulator
C3L21_RS02980	COG1959	2 iron, 2 sulfur cluster binding
C3L21_RS02985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3L21_RS02985	COG0517	IMP dehydrogenase activity
C3L21_RS02995	COG1368	sulfuric ester hydrolase activity
C3L21_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS03005	COG0156	8-amino-7-oxononanoate synthase activity
C3L21_RS03020	COG1335	isochorismatase
C3L21_RS03025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C3L21_RS03055	COG2132	Multicopper oxidase
C3L21_RS03085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3L21_RS03100	COG5328	Belongs to the UPF0262 family
C3L21_RS03110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3L21_RS03115	COG0424	maF-like protein
C3L21_RS03120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C3L21_RS03165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3L21_RS03180	COG4952	isomerase
C3L21_RS03185	COG3347	Dehydrogenase
C3L21_RS03185	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS03190	COG1349	DNA-binding transcription factor activity
C3L21_RS03200	COG1129	ABC transporter
C3L21_RS03205	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS03215	COG3254	rhamnose metabolic process
C3L21_RS03225	COG0840	transmembrane signaling receptor activity
C3L21_RS03240	COG0643	Histidine kinase
C3L21_RS03240	COG2198	Histidine kinase
C3L21_RS03245	COG0835	chemotaxis
C3L21_RS03250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C3L21_RS03255	COG2201	protein-glutamate methylesterase activity
C3L21_RS03260	COG0745	RESPONSE REGULATOR receiver
C3L21_RS03265	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C3L21_RS03275	COG1766	The M ring may be actively involved in energy transduction
C3L21_RS03280	COG2771	luxR family
C3L21_RS03295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3L21_RS03300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3L21_RS03305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3L21_RS03310	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3L21_RS03315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3L21_RS03325	COG4786	Flagellar basal body rod
C3L21_RS03330	COG1157	protein secretion by the type III secretion system
C3L21_RS03340	COG1815	bacterial-type flagellum-dependent cell motility
C3L21_RS03345	COG1558	bacterial-type flagellum-dependent cell motility
C3L21_RS03350	COG1677	Flagellar hook-basal body complex protein FliE
C3L21_RS03355	COG4786	Flagellar basal body rod
C3L21_RS03360	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C3L21_RS03365	COG1706	bacterial-type flagellum-dependent cell motility
C3L21_RS03375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C3L21_RS03385	COG1338	Plays a role in the flagellum-specific transport system
C3L21_RS03405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C3L21_RS03415	COG1360	Flagellar Motor Protein
C3L21_RS03440	COG1749	Flagellar hook protein flgE
C3L21_RS03460	COG5443	negative regulation of bacterial-type flagellum assembly
C3L21_RS03465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C3L21_RS03470	COG4794	Type iii secretion
C3L21_RS03475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3L21_RS03510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3L21_RS03515	COG1609	Transcriptional regulator
C3L21_RS03520	COG1653	transport
C3L21_RS03525	COG1175	transmembrane transport
C3L21_RS03530	COG0395	ABC-type sugar transport system, permease component
C3L21_RS03535	COG0366	Alpha amylase catalytic
C3L21_RS03540	COG3842	ATPase activity
C3L21_RS03550	COG0129	dihydroxy-acid dehydratase activity
C3L21_RS03555	COG0363	glucosamine-6-phosphate deaminase activity
C3L21_RS03560	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3L21_RS03565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS03575	COG2081	HI0933 family
C3L21_RS03585	COG2972	Histidine kinase
C3L21_RS03585	COG0840	transmembrane signaling receptor activity
C3L21_RS03655	COG2224	Isocitrate lyase
C3L21_RS03670	COG3842	ATPase activity
C3L21_RS03675	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS03680	COG1177	transmembrane transport
C3L21_RS03690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3L21_RS03695	COG1178	ABC-type Fe3 transport system permease component
C3L21_RS03700	COG2205	protein histidine kinase activity
C3L21_RS03745	COG1840	ABC-type Fe3 transport system, periplasmic component
C3L21_RS03750	COG1959	2 iron, 2 sulfur cluster binding
C3L21_RS03755	COG0747	negative chemotaxis
C3L21_RS03760	COG0601	transmembrane transport
C3L21_RS03765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS03770	COG0444	Belongs to the ABC transporter superfamily
C3L21_RS03775	COG4608	Belongs to the ABC transporter superfamily
C3L21_RS03780	COG0251	oxidation-reduction process
C3L21_RS03795	COG0784	Response regulator, receiver
C3L21_RS03820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS03830	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS03840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3L21_RS03850	COG1285	pathogenesis
C3L21_RS03905	COG2059	Chromate
C3L21_RS03930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C3L21_RS03940	COG0477	Major facilitator Superfamily
C3L21_RS03960	COG0412	Dienelactone hydrolase
C3L21_RS03965	COG0583	DNA-binding transcription factor activity
C3L21_RS03970	COG0753	catalase activity
C3L21_RS03975	COG0583	DNA-binding transcription factor activity
C3L21_RS04010	COG0306	phosphate transporter
C3L21_RS04020	COG1725	Transcriptional regulator
C3L21_RS04030	COG0583	DNA-binding transcription factor activity
C3L21_RS04035	COG0277	FAD linked oxidase domain protein
C3L21_RS04040	COG0277	FAD linked oxidase domain protein
C3L21_RS04045	COG0247	lactate metabolic process
C3L21_RS04050	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS04050	COG1388	LysM domain
C3L21_RS04055	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS04065	COG2818	Glycosylase
C3L21_RS04070	COG1953	Uracil, thiamine, allantoin
C3L21_RS04085	COG0124	histidyl-tRNA synthetase
C3L21_RS04090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C3L21_RS04095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3L21_RS04100	COG0625	glutathione transferase activity
C3L21_RS04110	COG0459	protein refolding
C3L21_RS04115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3L21_RS04130	COG0196	riboflavin kinase activity
C3L21_RS04135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3L21_RS04150	COG0590	tRNA wobble adenosine to inosine editing
C3L21_RS04155	COG1187	pseudouridine synthase activity
C3L21_RS04160	COG0742	ribosomal rna small subunit methyltransferase
C3L21_RS04165	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3L21_RS04170	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
C3L21_RS04180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3L21_RS04180	COG0475	glutathione-regulated potassium exporter activity
C3L21_RS04185	COG0312	modulator of DNA gyrase
C3L21_RS04190	COG0483	inositol monophosphate 1-phosphatase activity
C3L21_RS04200	COG1519	Transferase
C3L21_RS04210	COG1663	tetraacyldisaccharide 4'-kinase activity
C3L21_RS04220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3L21_RS04230	COG5001	Diguanylate cyclase
C3L21_RS04230	COG3300	MHYT domain
C3L21_RS04235	COG0583	DNA-binding transcription factor activity
C3L21_RS04240	COG5598	trimethylamine methyltransferase
C3L21_RS04255	COG0129	dihydroxy-acid dehydratase activity
C3L21_RS04260	COG3386	PFAM SMP-30 Gluconolaconase
C3L21_RS04265	COG0800	Aldolase
C3L21_RS04270	COG3734	2-keto-3-deoxy-galactonokinase
C3L21_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS04280	COG1414	Transcriptional regulator
C3L21_RS04290	COG2771	luxR family
C3L21_RS04295	COG0489	protein tyrosine kinase activity
C3L21_RS04300	COG0598	Magnesium transport protein CorA
C3L21_RS04305	COG3158	transport of potassium into the cell
C3L21_RS04320	COG0356	it plays a direct role in the translocation of protons across the membrane
C3L21_RS04325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3L21_RS04330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3L21_RS04335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3L21_RS04345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3L21_RS04365	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3L21_RS04370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3L21_RS04380	COG0142	geranyltranstransferase activity
C3L21_RS04405	COG0752	glycyl-tRNA synthetase alpha subunit
C3L21_RS04415	COG1704	LemA family
C3L21_RS04425	COG0751	glycine-tRNA ligase activity
C3L21_RS04430	COG1683	Conserved Protein
C3L21_RS04440	COG0151	Belongs to the GarS family
C3L21_RS04445	COG5001	Diguanylate cyclase
C3L21_RS04455	COG2223	nitrite transmembrane transporter activity
C3L21_RS04460	COG4977	sequence-specific DNA binding
C3L21_RS04465	COG3713	MltA-interacting MipA family protein
C3L21_RS04470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C3L21_RS04490	COG0009	L-threonylcarbamoyladenylate synthase
C3L21_RS04500	COG4638	Rieske (2fe-2S)
C3L21_RS04505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3L21_RS04535	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS04555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3L21_RS04565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3L21_RS04570	COG1741	Belongs to the pirin family
C3L21_RS04575	COG1722	exodeoxyribonuclease VII activity
C3L21_RS04580	COG0123	including yeast histone deacetylase and acetoin utilization protein
C3L21_RS04595	COG0183	Belongs to the thiolase family
C3L21_RS04600	COG0318	PFAM AMP-dependent synthetase and ligase
C3L21_RS04605	COG1268	BioY protein
C3L21_RS04610	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C3L21_RS04615	COG1122	ATPase activity
C3L21_RS04620	COG3214	Protein conserved in bacteria
C3L21_RS04625	COG0312	modulator of DNA gyrase
C3L21_RS04640	COG0259	pyridoxamine-phosphate oxidase activity
C3L21_RS04650	COG0484	heat shock protein binding
C3L21_RS04655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3L21_RS04670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3L21_RS04675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3L21_RS04675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3L21_RS04685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3L21_RS04685	COG1565	acr, cog1565
C3L21_RS04690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3L21_RS04695	COG0109	protoheme IX farnesyltransferase activity
C3L21_RS04705	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C3L21_RS04725	COG3346	SURF1 family
C3L21_RS04730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3L21_RS04735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3L21_RS04740	COG0328	RNA-DNA hybrid ribonuclease activity
C3L21_RS04745	COG0678	peroxiredoxin activity
C3L21_RS04745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C3L21_RS04755	COG1678	Uncharacterized ACR, COG1678
C3L21_RS04760	COG5001	Diguanylate cyclase
C3L21_RS04765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3L21_RS04770	COG0612	Peptidase, M16
C3L21_RS04790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3L21_RS04800	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C3L21_RS04830	COG1196	nuclear chromosome segregation
C3L21_RS04835	COG0574	Belongs to the PEP-utilizing enzyme family
C3L21_RS04835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3L21_RS04870	COG3264	Mechanosensitive ion channel
C3L21_RS04870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C3L21_RS04895	COG2895	sulfate adenylyltransferase (ATP) activity
C3L21_RS04900	COG0175	sulfate reduction
C3L21_RS04905	COG0175	sulfate reduction
C3L21_RS04920	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C3L21_RS04925	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS04930	COG3119	arylsulfatase activity
C3L21_RS04935	COG1309	transcriptional regulator
C3L21_RS04945	COG5001	Diguanylate cyclase
C3L21_RS04945	COG3300	MHYT domain
C3L21_RS04970	COG0583	DNA-binding transcription factor activity
C3L21_RS04975	COG0625	glutathione transferase activity
C3L21_RS04985	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS04985	COG1388	LysM domain
C3L21_RS04990	COG1846	Transcriptional regulator
C3L21_RS04995	COG1764	response to oxidative stress
C3L21_RS05000	COG2824	Alkylphosphonate utilization operon protein PhnA
C3L21_RS05005	COG0433	COG0433 Predicted ATPase
C3L21_RS05020	COG0656	L-ascorbic acid biosynthetic process
C3L21_RS05030	COG4106	trans-aconitate 2-methyltransferase activity
C3L21_RS05045	COG1063	alcohol dehydrogenase
C3L21_RS05050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3L21_RS05060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3L21_RS05080	COG2010	Cytochrome c
C3L21_RS05090	COG0789	Transcriptional regulator
C3L21_RS05100	COG4993	Dehydrogenase
C3L21_RS05105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C3L21_RS05120	COG2514	catechol 2,3-dioxygenase activity
C3L21_RS05125	COG0589	response to stress
C3L21_RS05135	COG1272	protein, Hemolysin III
C3L21_RS05145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3L21_RS05155	COG2111	Na H antiporter
C3L21_RS05160	COG1006	Multisubunit Na H antiporter MnhC subunit
C3L21_RS05175	COG2212	antiporter activity
C3L21_RS05180	COG1320	monovalent cation:proton antiporter activity
C3L21_RS05185	COG4957	zinc ion binding
C3L21_RS05190	COG2166	iron-sulfur cluster assembly
C3L21_RS05200	COG2205	protein histidine kinase activity
C3L21_RS05250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3L21_RS05255	COG2983	Belongs to the UPF0260 family
C3L21_RS05275	COG0745	RESPONSE REGULATOR receiver
C3L21_RS05280	COG2205	protein histidine kinase activity
C3L21_RS05290	COG4235	cytochrome complex assembly
C3L21_RS05295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C3L21_RS05300	COG1138	Cytochrome C-type biogenesis protein
C3L21_RS05305	COG3088	subunit of a heme lyase
C3L21_RS05310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3L21_RS05315	COG0745	RESPONSE REGULATOR receiver
C3L21_RS05320	COG2205	protein histidine kinase activity
C3L21_RS05325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3L21_RS05330	COG2205	protein histidine kinase activity
C3L21_RS05330	COG2202	Pas domain
C3L21_RS05335	COG0308	aminopeptidase N
C3L21_RS05345	COG2814	Major facilitator Superfamily
C3L21_RS05360	COG1573	uracil-dna glycosylase
C3L21_RS05365	COG0443	Heat shock 70 kDa protein
C3L21_RS05380	COG4176	ABC-type proline glycine betaine transport system permease component
C3L21_RS05390	COG1733	regulation of RNA biosynthetic process
C3L21_RS05400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C3L21_RS05405	COG0463	Glycosyl transferase, family 2
C3L21_RS05415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3L21_RS05420	COG1742	UPF0060 membrane protein
C3L21_RS05435	COG0625	glutathione transferase activity
C3L21_RS05450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3L21_RS05465	COG3093	addiction module antidote protein HigA
C3L21_RS05470	COG3549	Plasmid maintenance system killer
C3L21_RS05480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C3L21_RS05490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C3L21_RS05500	COG0741	lytic transglycosylase activity
C3L21_RS05505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3L21_RS05510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3L21_RS05530	COG1758	RNA polymerase activity
C3L21_RS05560	COG0736	holo-[acyl-carrier-protein] synthase activity
C3L21_RS05565	COG0681	Belongs to the peptidase S26 family
C3L21_RS05570	COG0571	ribonuclease III activity
C3L21_RS05575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3L21_RS05580	COG0431	NADPH-dependent FMN reductase
C3L21_RS05590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3L21_RS05600	COG0584	glycerophosphoryl diester phosphodiesterase
C3L21_RS05610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3L21_RS05615	COG2183	response to ionizing radiation
C3L21_RS05625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3L21_RS05630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS05650	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS05655	COG1381	Involved in DNA repair and RecF pathway recombination
C3L21_RS05670	COG1418	mRNA catabolic process
C3L21_RS05685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3L21_RS05690	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3L21_RS05700	COG2032	superoxide dismutase activity
C3L21_RS05730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C3L21_RS05755	COG1051	belongs to the nudix hydrolase family
C3L21_RS05775	COG0215	cysteine-tRNA ligase activity
C3L21_RS05800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3L21_RS05805	COG2962	Rard protein
C3L21_RS05820	COG5265	(ABC) transporter
C3L21_RS05825	COG0688	phosphatidylethanolamine metabolic process
C3L21_RS05830	COG1183	phosphatidylcholine synthase activity
C3L21_RS05835	COG4221	oxidoreductase activity
C3L21_RS05840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3L21_RS05855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3L21_RS05875	COG0305	Participates in initiation and elongation during chromosome replication
C3L21_RS05895	COG0359	binds to the 23S rRNA
C3L21_RS05905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3L21_RS05910	COG0360	Binds together with S18 to 16S ribosomal RNA
C3L21_RS05920	COG0667	Aldo Keto reductase
C3L21_RS05925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3L21_RS05935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3L21_RS05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3L21_RS05945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3L21_RS05950	COG1561	YicC-like family, N-terminal region
C3L21_RS05955	COG0194	GDP metabolic process
C3L21_RS05965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3L21_RS05970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C3L21_RS05995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3L21_RS06015	COG0488	(ABC) transporter
C3L21_RS06025	COG0318	PFAM AMP-dependent synthetase and ligase
C3L21_RS06040	COG0105	UTP biosynthetic process
C3L21_RS06060	COG0314	molybdopterin synthase activity
C3L21_RS06075	COG0322	excinuclease ABC activity
C3L21_RS06080	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS06105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C3L21_RS06110	COG0243	molybdopterin cofactor binding
C3L21_RS06115	COG0494	nUDIX hydrolase
C3L21_RS06130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3L21_RS06135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3L21_RS06140	COG0628	permease
C3L21_RS06150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3L21_RS06155	COG0248	Ppx GppA phosphatase
C3L21_RS06165	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3L21_RS06170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C3L21_RS06175	COG2132	Multicopper oxidase
C3L21_RS06185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3L21_RS06195	COG0459	protein refolding
C3L21_RS06210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3L21_RS06225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C3L21_RS06235	COG0113	porphobilinogen synthase activity
C3L21_RS06250	COG2989	Protein conserved in bacteria
C3L21_RS06255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3L21_RS06260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3L21_RS06265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3L21_RS06265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3L21_RS06280	COG0519	Catalyzes the synthesis of GMP from XMP
C3L21_RS06290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3L21_RS06295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3L21_RS06300	COG2814	Major facilitator Superfamily
C3L21_RS06305	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C3L21_RS06325	COG0416	fatty acid biosynthetic process
C3L21_RS06330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3L21_RS06335	COG0776	regulation of translation
C3L21_RS06370	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS06385	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS06405	COG0110	maltose O-acetyltransferase activity
C3L21_RS06420	COG1612	heme a metabolic process
C3L21_RS06425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3L21_RS06430	COG0010	Belongs to the arginase family
C3L21_RS06435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3L21_RS06440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3L21_RS06450	COG1024	Enoyl-CoA hydratase
C3L21_RS06460	COG1832	CoA-binding protein
C3L21_RS06475	COG2801	Transposase and inactivated derivatives
C3L21_RS06475	COG3415	Transposase
C3L21_RS06480	COG2124	cytochrome p450
C3L21_RS06490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3L21_RS06495	COG0740	serine-type endopeptidase activity
C3L21_RS06500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3L21_RS06505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3L21_RS06510	COG0776	regulation of translation
C3L21_RS06525	COG0420	3'-5' exonuclease activity
C3L21_RS06530	COG4717	serine-type aminopeptidase activity
C3L21_RS06555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3L21_RS06560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3L21_RS06565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3L21_RS06570	COG0649	NAD binding
C3L21_RS06580	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C3L21_RS06585	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3L21_RS06590	COG0052	Belongs to the universal ribosomal protein uS2 family
C3L21_RS06600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3L21_RS06605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3L21_RS06615	COG0713	ATP synthesis coupled electron transport
C3L21_RS06630	COG1007	ATP synthesis coupled electron transport
C3L21_RS06660	COG0442	prolyl-tRNA aminoacylation
C3L21_RS06670	COG1136	(ABC) transporter
C3L21_RS06675	COG0587	DNA-directed DNA polymerase activity
C3L21_RS06685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3L21_RS06695	COG0784	Response regulator, receiver
C3L21_RS06700	COG3706	GGDEF domain
C3L21_RS06700	COG0745	RESPONSE REGULATOR receiver
C3L21_RS06705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3L21_RS06725	COG0557	exoribonuclease II activity
C3L21_RS06730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3L21_RS06730	COG1754	DNA topoisomerase type I activity
C3L21_RS06735	COG0758	DNA mediated transformation
C3L21_RS06740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3L21_RS06745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3L21_RS06750	COG0540	Belongs to the ATCase OTCase family
C3L21_RS06755	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS06775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3L21_RS06780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C3L21_RS06785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3L21_RS06790	COG0154	amidase activity
C3L21_RS06795	COG3811	Belongs to the UPF0386 family
C3L21_RS06800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3L21_RS06820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C3L21_RS06825	COG0439	Biotin carboxylase
C3L21_RS06830	COG0511	ligase activity, forming carbon-carbon bonds
C3L21_RS06835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3L21_RS06860	COG1530	ribonuclease E activity
C3L21_RS06870	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3L21_RS06875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3L21_RS06885	COG3385	transposase activity
C3L21_RS06895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3L21_RS06935	COG0328	RNA-DNA hybrid ribonuclease activity
C3L21_RS07080	COG3179	chitinase
C3L21_RS07130	COG4584	PFAM Integrase catalytic
C3L21_RS07135	COG1484	DNA-dependent DNA replication
C3L21_RS07185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3L21_RS07195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3L21_RS07210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3L21_RS07220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS07245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3L21_RS07250	COG0081	regulation of translation
C3L21_RS07255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3L21_RS07260	COG0222	ribosome binding
C3L21_RS07265	COG0085	RNA polymerase activity
C3L21_RS07270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3L21_RS07280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3L21_RS07285	COG0049	tRNA binding
C3L21_RS07290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3L21_RS07300	COG0051	transcription antitermination factor activity, RNA binding
C3L21_RS07315	COG0051	transcription antitermination factor activity, RNA binding
C3L21_RS07320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3L21_RS07325	COG0088	Forms part of the polypeptide exit tunnel
C3L21_RS07330	COG0089	rRNA binding
C3L21_RS07335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3L21_RS07345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3L21_RS07350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3L21_RS07355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3L21_RS07360	COG0255	Belongs to the universal ribosomal protein uL29 family
C3L21_RS07365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3L21_RS07370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3L21_RS07375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3L21_RS07380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3L21_RS07385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3L21_RS07390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3L21_RS07395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3L21_RS07400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3L21_RS07405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3L21_RS07410	COG1841	ribosomal large subunit assembly
C3L21_RS07415	COG0200	Binds to the 23S rRNA
C3L21_RS07425	COG0563	adenylate kinase activity
C3L21_RS07430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3L21_RS07435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3L21_RS07440	COG0202	RNA polymerase activity
C3L21_RS07445	COG0203	ribosomal protein L17
C3L21_RS07455	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C3L21_RS07460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3L21_RS07465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3L21_RS07470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3L21_RS07485	COG0546	phosphoglycolate phosphatase activity
C3L21_RS07490	COG0564	pseudouridine synthase activity
C3L21_RS07495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3L21_RS07500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C3L21_RS07510	COG1671	Belongs to the UPF0178 family
C3L21_RS07515	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C3L21_RS07525	COG0321	lipoyl(octanoyl) transferase activity
C3L21_RS07535	COG2766	serine protein kinase
C3L21_RS07540	COG2718	Belongs to the UPF0229 family
C3L21_RS07545	COG2719	SpoVR family
C3L21_RS07550	COG3415	Transposase
C3L21_RS07550	COG2801	Transposase and inactivated derivatives
C3L21_RS07565	COG0242	peptide deformylase activity
C3L21_RS07570	COG2239	Acts as a magnesium transporter
C3L21_RS07595	COG1760	l-serine dehydratase
C3L21_RS07630	COG3415	Transposase
C3L21_RS07630	COG2801	Transposase and inactivated derivatives
C3L21_RS07650	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C3L21_RS07665	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3L21_RS07670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3L21_RS07675	COG0302	gtp cyclohydrolase
C3L21_RS07685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3L21_RS07700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3L21_RS07740	COG0187	DNA topoisomerase II activity
C3L21_RS07765	COG0149	triose-phosphate isomerase activity
C3L21_RS07770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3L21_RS07775	COG0504	CTP synthase activity
C3L21_RS07785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C3L21_RS07790	COG0148	phosphopyruvate hydratase activity
C3L21_RS07805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3L21_RS07810	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3L21_RS07810	COG0022	dehydrogenase e1 component
C3L21_RS07815	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3L21_RS07830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3L21_RS07840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3L21_RS07850	COG2867	negative regulation of translational initiation
C3L21_RS07860	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3L21_RS07860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3L21_RS07870	COG3852	Histidine kinase
C3L21_RS07875	COG2204	response regulator
C3L21_RS07880	COG5000	phosphorelay sensor kinase activity
C3L21_RS07885	COG2204	response regulator
C3L21_RS07890	COG0569	domain protein
C3L21_RS07895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3L21_RS07900	COG1923	regulation of RNA biosynthetic process
C3L21_RS07905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3L21_RS07910	COG3956	TIGRFAM MazG family protein
C3L21_RS07920	COG1648	precorrin-2 dehydrogenase activity
C3L21_RS07920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3L21_RS07930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3L21_RS07960	COG1126	abc transporter atp-binding protein
C3L21_RS07965	COG0765	amino acid transport
C3L21_RS07970	COG4597	amino acid ABC transporter
C3L21_RS07975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS07980	COG0626	cystathionine gamma-synthase activity
C3L21_RS08005	COG1045	serine acetyltransferase
C3L21_RS08020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3L21_RS08040	COG0537	adenosine 5'-monophosphoramidase activity
C3L21_RS08065	COG0052	Belongs to the universal ribosomal protein uS2 family
C3L21_RS08070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3L21_RS08075	COG0528	UMP kinase activity
C3L21_RS08080	COG0233	cytoplasmic translational termination
C3L21_RS08085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3L21_RS08095	COG0750	zinc metalloprotease
C3L21_RS08105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3L21_RS08110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3L21_RS08115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3L21_RS08125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3L21_RS08130	COG0372	Belongs to the citrate synthase family
C3L21_RS08145	COG0848	biopolymer transport protein
C3L21_RS08150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3L21_RS08165	COG0525	valine-tRNA ligase activity
C3L21_RS08175	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C3L21_RS08185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3L21_RS08195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C3L21_RS08200	COG0018	arginyl-trna synthetase
C3L21_RS08210	COG1472	Belongs to the glycosyl hydrolase 3 family
C3L21_RS08215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C3L21_RS08220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3L21_RS08225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3L21_RS08230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3L21_RS08235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3L21_RS08240	COG0805	protein transport
C3L21_RS08245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3L21_RS08250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C3L21_RS08255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3L21_RS08300	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C3L21_RS08575	COG4974	Belongs to the 'phage' integrase family
C3L21_RS08585	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3L21_RS08590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3L21_RS08590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3L21_RS08595	COG0509	glycine decarboxylation via glycine cleavage system
C3L21_RS08600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3L21_RS08630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3L21_RS08640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3L21_RS08645	COG0629	single-stranded DNA binding
C3L21_RS08650	COG2095	MarC family integral membrane protein
C3L21_RS08655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3L21_RS08675	COG1902	pentaerythritol trinitrate reductase activity
C3L21_RS08685	COG0583	DNA-binding transcription factor activity
C3L21_RS08690	COG0492	ferredoxin-NADP+ reductase activity
C3L21_RS08695	COG1522	sequence-specific DNA binding
C3L21_RS08700	COG0463	Glycosyl transferase, family 2
C3L21_RS08705	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS08710	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS08715	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS08720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3L21_RS08735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3L21_RS08740	COG1063	alcohol dehydrogenase
C3L21_RS08745	COG2321	neutral zinc metallopeptidase
C3L21_RS08760	COG0534	Mate efflux family protein
C3L21_RS08770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3L21_RS08775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3L21_RS08780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3L21_RS08785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3L21_RS08790	COG0343	queuine tRNA-ribosyltransferase activity
C3L21_RS08800	COG0300	oxidoreductase activity
C3L21_RS08825	COG1388	LysM domain
C3L21_RS08825	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS08855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3L21_RS08860	COG2801	Transposase and inactivated derivatives
C3L21_RS08870	COG0084	hydrolase, TatD family'
C3L21_RS08875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3L21_RS08885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3L21_RS08895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C3L21_RS08935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3L21_RS09010	COG0110	maltose O-acetyltransferase activity
C3L21_RS09105	COG0740	serine-type endopeptidase activity
C3L21_RS09110	COG4695	Portal protein
C3L21_RS09155	COG0592	DNA-directed DNA polymerase activity
C3L21_RS09245	COG2076	Multidrug Resistance protein
C3L21_RS09265	COG4221	oxidoreductase activity
C3L21_RS09280	COG2801	Transposase and inactivated derivatives
C3L21_RS09280	COG3415	Transposase
C3L21_RS09285	COG2897	thiosulfate sulfurtransferase activity
C3L21_RS09300	COG0686	Belongs to the AlaDH PNT family
C3L21_RS09305	COG1522	sequence-specific DNA binding
C3L21_RS09310	COG0737	Belongs to the 5'-nucleotidase family
C3L21_RS09320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3L21_RS09325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3L21_RS09340	COG3795	YCII-related domain
C3L21_RS09365	COG0655	NAD(P)H dehydrogenase (quinone) activity
C3L21_RS09370	COG1058	Belongs to the CinA family
C3L21_RS09370	COG1546	Belongs to the CinA family
C3L21_RS09375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C3L21_RS09380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3L21_RS09380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3L21_RS09385	COG0347	Belongs to the P(II) protein family
C3L21_RS09390	COG0174	glutamine synthetase
C3L21_RS09435	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C3L21_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS09450	COG0583	DNA-binding transcription factor activity
C3L21_RS09485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3L21_RS09485	COG1672	PFAM Archaeal ATPase
C3L21_RS09495	COG0708	Exodeoxyribonuclease III
C3L21_RS09510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3L21_RS09515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C3L21_RS09520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3L21_RS09530	COG3153	acetyltransferase
C3L21_RS09535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3L21_RS09540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3L21_RS09550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3L21_RS09555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3L21_RS09560	COG0134	indole-3-glycerol-phosphate synthase activity
C3L21_RS09565	COG0315	cyclic pyranopterin monophosphate synthase activity
C3L21_RS09570	COG0303	'Molybdopterin
C3L21_RS09580	COG1253	flavin adenine dinucleotide binding
C3L21_RS09585	COG2186	Transcriptional regulator
C3L21_RS09615	COG1183	phosphatidylcholine synthase activity
C3L21_RS09625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3L21_RS09630	COG0679	Auxin Efflux Carrier
C3L21_RS09635	COG0785	Cytochrome C biogenesis protein
C3L21_RS09675	COG4372	Transposase
C3L21_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS09750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3L21_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS09765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS09775	COG3453	Protein conserved in bacteria
C3L21_RS09775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3L21_RS09785	COG1522	sequence-specific DNA binding
C3L21_RS09820	COG0583	DNA-binding transcription factor activity
C3L21_RS09860	COG1278	Cold shock
C3L21_RS09905	COG0436	Aminotransferase
C3L21_RS09915	COG3243	poly(R)-hydroxyalkanoic acid synthase
C3L21_RS09925	COG0024	Methionine aminopeptidase
C3L21_RS09930	COG2003	Belongs to the UPF0758 family
C3L21_RS09945	COG2151	metal-sulfur cluster biosynthetic enzyme
C3L21_RS09950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3L21_RS09955	COG0719	Fe-S assembly protein
C3L21_RS09960	COG0396	ATPase activity
C3L21_RS09965	COG0719	Fe-S assembly protein
C3L21_RS09975	COG2945	thiolester hydrolase activity
C3L21_RS09985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C3L21_RS09990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3L21_RS10000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3L21_RS10005	COG2833	Protein of unknown function (DUF455)
C3L21_RS10010	COG0739	heme binding
C3L21_RS10015	COG0513	Belongs to the DEAD box helicase family
C3L21_RS10030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3L21_RS10035	COG3608	succinylglutamate desuccinylase aspartoacylase
C3L21_RS10035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C3L21_RS10050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3L21_RS10055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3L21_RS10065	COG3191	aminopeptidase activity
C3L21_RS10085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C3L21_RS10115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3L21_RS10120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3L21_RS10125	COG0047	phosphoribosylformylglycinamidine synthase activity
C3L21_RS10140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS10150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3L21_RS10170	COG2814	Major facilitator Superfamily
C3L21_RS10175	COG2814	Major facilitator Superfamily
C3L21_RS10180	COG0483	inositol monophosphate 1-phosphatase activity
C3L21_RS10185	COG0037	tRNA processing
C3L21_RS10190	COG2066	Belongs to the glutaminase family
C3L21_RS10195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3L21_RS10205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3L21_RS10210	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C3L21_RS10220	COG0538	isocitrate dehydrogenase activity
C3L21_RS10245	COG0659	secondary active sulfate transmembrane transporter activity
C3L21_RS10250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3L21_RS10255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3L21_RS10260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3L21_RS10265	COG2313	pseudouridylate synthase activity
C3L21_RS10280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3L21_RS10290	COG3106	COG3106 Predicted ATPase
C3L21_RS10295	COG3768	UPF0283 membrane protein
C3L21_RS10310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3L21_RS10315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3L21_RS10330	COG0633	Ferredoxin
C3L21_RS10345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3L21_RS10345	COG2857	Cytochrome c1
C3L21_RS10360	COG1132	(ABC) transporter
C3L21_RS10365	COG1132	(ABC) transporter
C3L21_RS10370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3L21_RS10375	COG0431	NADPH-dependent FMN reductase
C3L21_RS10380	COG0789	Transcriptional regulator
C3L21_RS10395	COG0408	coproporphyrinogen oxidase activity
C3L21_RS10415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C3L21_RS10415	COG3218	ABC-type transport auxiliary lipoprotein component
C3L21_RS10425	COG1127	ABC transporter
C3L21_RS10430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3L21_RS10435	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS10440	COG2814	Major facilitator Superfamily
C3L21_RS10455	COG0281	malic enzyme
C3L21_RS10455	COG0280	phosphate acetyltransferase
C3L21_RS10460	COG2197	response regulator
C3L21_RS10475	COG0778	Nitroreductase
C3L21_RS10480	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS10495	COG1609	Transcriptional regulator
C3L21_RS10505	COG0823	Involved in the tonB-independent uptake of proteins
C3L21_RS10515	COG1368	sulfuric ester hydrolase activity
C3L21_RS10545	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C3L21_RS10560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C3L21_RS10565	COG0546	phosphoglycolate phosphatase activity
C3L21_RS10570	COG2989	Protein conserved in bacteria
C3L21_RS10575	COG0114	fumarate hydratase activity
C3L21_RS10590	COG1846	Transcriptional regulator
C3L21_RS10600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3L21_RS10605	COG0697	spore germination
C3L21_RS10610	COG0746	molybdenum cofactor guanylyltransferase activity
C3L21_RS10615	COG1763	Mo-molybdopterin cofactor biosynthetic process
C3L21_RS10625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS10640	COG5425	PFAM Usg family protein
C3L21_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS10665	COG2084	Dehydrogenase
C3L21_RS10675	COG1522	sequence-specific DNA binding
C3L21_RS10680	COG1573	uracil-dna glycosylase
C3L21_RS10695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C3L21_RS10700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3L21_RS10705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C3L21_RS10720	COG0842	Transport permease protein
C3L21_RS10725	COG1131	(ABC) transporter
C3L21_RS10730	COG0640	Transcriptional regulator
C3L21_RS10735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3L21_RS10735	COG3453	Protein conserved in bacteria
C3L21_RS10750	COG0840	transmembrane signaling receptor activity
C3L21_RS10755	COG1607	acyl-coa hydrolase
C3L21_RS10770	COG0556	nucleotide-excision repair
C3L21_RS10780	COG0484	heat shock protein binding
C3L21_RS10795	COG1278	Cold shock
C3L21_RS10800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3L21_RS11140	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3L21_RS11150	COG0735	belongs to the Fur family
C3L21_RS11155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3L21_RS11160	COG1121	(ABC) transporter
C3L21_RS11165	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C3L21_RS11175	COG3507	Belongs to the glycosyl hydrolase 43 family
C3L21_RS11185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS11195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C3L21_RS11200	COG0667	Aldo Keto reductase
C3L21_RS11215	COG3250	beta-galactosidase activity
C3L21_RS11220	COG3842	ATPase activity
C3L21_RS11225	COG0395	ABC-type sugar transport system, permease component
C3L21_RS11250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3L21_RS11255	COG1115	amino acid carrier protein
C3L21_RS11280	COG1560	Kdo2-lipid A biosynthetic process
C3L21_RS11290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3L21_RS11300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3L21_RS11305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3L21_RS11310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C3L21_RS11320	COG1797	cobyrinic acid a,c-diamide synthase activity
C3L21_RS11340	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS11350	COG0747	negative chemotaxis
C3L21_RS11355	COG0601	transmembrane transport
C3L21_RS11410	COG1492	cobalamin metabolic process
C3L21_RS11425	COG4175	Glycine betaine
C3L21_RS11425	COG0517	IMP dehydrogenase activity
C3L21_RS11430	COG3609	addiction module antidote protein, CC2985 family
C3L21_RS11445	COG0583	DNA-binding transcription factor activity
C3L21_RS11450	COG0646	methionine synthase
C3L21_RS11450	COG1410	methionine synthase
C3L21_RS11470	COG3698	Phosphodiester glycosidase
C3L21_RS11480	COG5598	trimethylamine methyltransferase
C3L21_RS11485	COG5012	cobalamin binding
C3L21_RS11500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3L21_RS11535	COG1410	methionine synthase
C3L21_RS11535	COG0646	methionine synthase
C3L21_RS11560	COG0640	Transcriptional regulator
C3L21_RS11565	COG0583	DNA-binding transcription factor activity
C3L21_RS11635	COG0861	Integral membrane protein TerC family
C3L21_RS11640	COG1196	nuclear chromosome segregation
C3L21_RS11640	COG3264	Mechanosensitive ion channel
C3L21_RS11655	COG0471	metal ion transport
C3L21_RS11655	COG3273	potassium ion transport
C3L21_RS11690	COG0463	Glycosyl transferase, family 2
C3L21_RS11800	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
C3L21_RS11805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS11840	COG1793	dna ligase
C3L21_RS11840	COG3285	dna ligase
C3L21_RS11875	COG3179	chitinase
C3L21_RS12075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3L21_RS12165	COG3750	Belongs to the UPF0335 family
C3L21_RS12250	COG0384	phenazine biosynthesis protein PhzF
C3L21_RS12285	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C3L21_RS12300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3L21_RS12315	COG3842	ATPase activity
C3L21_RS12320	COG4149	molybdate abc transporter
C3L21_RS12330	COG1278	Cold shock
C3L21_RS12340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3L21_RS12350	COG0667	Aldo Keto reductase
C3L21_RS12355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS12365	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS12385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3L21_RS12395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS12400	COG1136	(ABC) transporter
C3L21_RS12400	COG0577	efflux transmembrane transporter activity
C3L21_RS12430	COG2271	Major facilitator Superfamily
C3L21_RS12435	COG1737	Transcriptional regulator
C3L21_RS12440	COG1252	NADH dehydrogenase
C3L21_RS12445	COG1522	sequence-specific DNA binding
C3L21_RS12450	COG1794	racemase activity, acting on amino acids and derivatives
C3L21_RS12455	COG1733	regulation of RNA biosynthetic process
C3L21_RS12470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS12475	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C3L21_RS12520	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3L21_RS12520	COG1672	PFAM Archaeal ATPase
C3L21_RS12525	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3L21_RS12530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3L21_RS12535	COG3180	Ammonia monooxygenase
C3L21_RS12555	COG1595	DNA-templated transcription, initiation
C3L21_RS12600	COG1278	Cold shock
C3L21_RS12605	COG0656	L-ascorbic acid biosynthetic process
C3L21_RS12610	COG0440	acetolactate synthase activity
C3L21_RS12615	COG0028	Belongs to the TPP enzyme family
C3L21_RS12635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3L21_RS12640	COG0560	Phosphoserine phosphatase
C3L21_RS12640	COG3830	Belongs to the UPF0237 family
C3L21_RS12645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3L21_RS12650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3L21_RS12665	COG0330	HflC and HflK could
C3L21_RS12685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3L21_RS12740	COG0277	FAD linked oxidase domain protein
C3L21_RS12750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3L21_RS12785	COG3706	GGDEF domain
C3L21_RS12805	COG0835	chemotaxis
C3L21_RS12810	COG0840	transmembrane signaling receptor activity
C3L21_RS12820	COG1999	signal sequence binding
C3L21_RS12825	COG2264	protein methyltransferase activity
C3L21_RS12840	COG0006	proline dipeptidase activity
C3L21_RS12860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3L21_RS12865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3L21_RS12875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3L21_RS12885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3L21_RS12895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3L21_RS12900	COG0849	cell division
C3L21_RS12905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3L21_RS12910	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3L21_RS12915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3L21_RS12920	COG0477	Major facilitator Superfamily
C3L21_RS12925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3L21_RS12930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3L21_RS12935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3L21_RS12945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3L21_RS12950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3L21_RS12960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3L21_RS12975	COG0275	rRNA processing
C3L21_RS12980	COG2001	Belongs to the MraZ family
C3L21_RS13000	COG3023	N-Acetylmuramoyl-L-alanine amidase
C3L21_RS13005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C3L21_RS13015	COG1280	lysine exporter protein (LysE YggA)
C3L21_RS13070	COG3719	Belongs to the RNase T2 family
C3L21_RS13075	COG2267	carboxylic ester hydrolase activity
C3L21_RS13085	COG0028	Belongs to the TPP enzyme family
C3L21_RS13105	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS13110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS13130	COG0174	glutamine synthetase
C3L21_RS13165	COG3842	ATPase activity
C3L21_RS13170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3L21_RS13180	COG4774	siderophore transport
C3L21_RS13185	COG3328	transposase activity
C3L21_RS13195	COG0149	triose-phosphate isomerase activity
C3L21_RS13200	COG1349	DNA-binding transcription factor activity
C3L21_RS13215	COG1070	Carbohydrate kinase
C3L21_RS13230	COG0235	Class ii aldolase
C3L21_RS13250	COG3842	ATPase activity
C3L21_RS13260	COG1175	transmembrane transport
C3L21_RS13265	COG1653	transport
C3L21_RS13275	COG2197	response regulator
C3L21_RS13280	COG3842	ATPase activity
C3L21_RS13290	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS13295	COG1177	transmembrane transport
C3L21_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS13310	COG3246	L-lysine catabolic process to acetate
C3L21_RS13315	COG0824	Thioesterase
C3L21_RS13315	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3L21_RS13320	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS13335	COG0747	negative chemotaxis
C3L21_RS13345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS13350	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS13380	COG0583	DNA-binding transcription factor activity
C3L21_RS13385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C3L21_RS13390	COG3842	ATPase activity
C3L21_RS13395	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS13400	COG1177	transmembrane transport
C3L21_RS13405	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS13470	COG1024	Enoyl-CoA hydratase
C3L21_RS13550	COG2968	Membrane
C3L21_RS13565	COG0432	Pfam Uncharacterised protein family UPF0047
C3L21_RS13570	COG5507	3-demethylubiquinone-9 3-methyltransferase
C3L21_RS13585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3L21_RS13595	COG1063	alcohol dehydrogenase
C3L21_RS13605	COG0514	ATP-dependent DNA helicase (RecQ)
C3L21_RS13610	COG0358	DNA primase activity
C3L21_RS13620	COG0505	Belongs to the CarA family
C3L21_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS13635	COG2084	Dehydrogenase
C3L21_RS13655	COG2133	pyrroloquinoline quinone binding
C3L21_RS13665	COG1278	Cold shock
C3L21_RS13675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3L21_RS13695	COG1846	Transcriptional regulator
C3L21_RS13700	COG0745	RESPONSE REGULATOR receiver
C3L21_RS13705	COG2205	protein histidine kinase activity
C3L21_RS13710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3L21_RS13730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3L21_RS13755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3L21_RS13760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C3L21_RS13770	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS13780	COG3135	benzoate transporter
C3L21_RS13785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3L21_RS13790	COG0193	aminoacyl-tRNA hydrolase activity
C3L21_RS13795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3L21_RS13815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3L21_RS13840	COG0714	Associated with various cellular activities
C3L21_RS13865	COG0435	Glutathione S-transferase
C3L21_RS13890	COG1595	DNA-templated transcription, initiation
C3L21_RS13900	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
C3L21_RS13905	COG4423	Transcription factor
C3L21_RS13910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3L21_RS13920	COG0740	serine-type endopeptidase activity
C3L21_RS13935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C3L21_RS13940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3L21_RS13945	COG0512	Glutamine amidotransferase of anthranilate synthase
C3L21_RS13945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3L21_RS13960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C3L21_RS13975	COG3385	transposase activity
C3L21_RS13980	COG2852	Protein conserved in bacteria
C3L21_RS14000	COG1435	thymidine kinase activity
C3L21_RS14040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C3L21_RS14045	COG0366	Alpha amylase catalytic
C3L21_RS14050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3L21_RS14055	COG3385	transposase activity
C3L21_RS14060	COG4608	Belongs to the ABC transporter superfamily
C3L21_RS14065	COG0444	Belongs to the ABC transporter superfamily
C3L21_RS14075	COG0601	transmembrane transport
C3L21_RS14090	COG2076	Multidrug Resistance protein
C3L21_RS14110	COG2346	COG2346, Truncated hemoglobins
C3L21_RS14160	COG4558	Periplasmic binding protein
C3L21_RS14165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3L21_RS14170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C3L21_RS14185	COG3920	Histidine kinase
C3L21_RS14185	COG2202	Pas domain
C3L21_RS14200	COG0784	Response regulator, receiver
C3L21_RS14235	COG1175	transmembrane transport
C3L21_RS14260	COG1063	alcohol dehydrogenase
C3L21_RS14265	COG0583	DNA-binding transcription factor activity
C3L21_RS14275	COG1309	transcriptional regulator
C3L21_RS14305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3L21_RS14310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3L21_RS14315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3L21_RS14330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C3L21_RS14335	COG0830	nickel cation binding
C3L21_RS14340	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C3L21_RS14365	COG0804	urea catabolic process
C3L21_RS14370	COG1442	glycosyl transferase family 8
C3L21_RS14375	COG3755	Protein conserved in bacteria
C3L21_RS14380	COG0832	Belongs to the urease beta subunit family
C3L21_RS14385	COG3813	Protein conserved in bacteria
C3L21_RS14390	COG0831	urea catabolic process
C3L21_RS14395	COG0829	nickel cation binding
C3L21_RS14400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3L21_RS14410	COG1846	Transcriptional regulator
C3L21_RS14455	COG0784	Response regulator, receiver
C3L21_RS14460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3L21_RS14470	COG0400	carboxylic ester hydrolase activity
C3L21_RS14490	COG0346	lactoylglutathione lyase activity
C3L21_RS14495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3L21_RS14505	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS14510	COG3842	ATPase activity
C3L21_RS14530	COG0436	Aminotransferase
C3L21_RS14545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS14550	COG0174	glutamine synthetase
C3L21_RS14560	COG1725	Transcriptional regulator
C3L21_RS14565	COG0626	cystathionine gamma-synthase activity
C3L21_RS14580	COG0395	ABC-type sugar transport system, permease component
C3L21_RS14585	COG3842	ATPase activity
C3L21_RS14595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3L21_RS14600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3L21_RS14605	COG1845	cytochrome c oxidase, subunit III
C3L21_RS14645	COG1063	alcohol dehydrogenase
C3L21_RS14670	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS14675	COG1129	ABC transporter
C3L21_RS14690	COG1473	amidohydrolase
C3L21_RS14695	COG0747	negative chemotaxis
C3L21_RS14715	COG0601	transmembrane transport
C3L21_RS14720	COG0583	DNA-binding transcription factor activity
C3L21_RS14725	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS14730	COG1129	ABC transporter
C3L21_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS14750	COG1802	Transcriptional regulator
C3L21_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS14775	COG2140	Oxalate decarboxylase
C3L21_RS14780	COG0800	Aldolase
C3L21_RS14790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3L21_RS14795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C3L21_RS14800	COG1737	Transcriptional regulator
C3L21_RS14805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3L21_RS14820	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS14825	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS14830	COG1129	ABC transporter
C3L21_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS14850	COG1070	Carbohydrate kinase
C3L21_RS14855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3L21_RS14860	COG0477	Major facilitator Superfamily
C3L21_RS14900	COG4774	siderophore transport
C3L21_RS14905	COG0174	glutamine synthetase
C3L21_RS14920	COG1335	isochorismatase
C3L21_RS14925	COG0683	leucine binding
C3L21_RS14930	COG0411	ABC transporter
C3L21_RS14935	COG0410	ABC transporter
C3L21_RS14940	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS14950	COG1335	isochorismatase
C3L21_RS14960	COG0402	S-adenosylhomocysteine deaminase activity
C3L21_RS14980	COG0601	transmembrane transport
C3L21_RS14985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS14995	COG1228	amidohydrolase
C3L21_RS15000	COG0444	Belongs to the ABC transporter superfamily
C3L21_RS15005	COG4608	Belongs to the ABC transporter superfamily
C3L21_RS15010	COG1802	Transcriptional regulator
C3L21_RS15040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C3L21_RS15075	COG0739	heme binding
C3L21_RS15080	COG0542	response to heat
C3L21_RS15095	COG2890	protein-(glutamine-N5) methyltransferase activity
C3L21_RS15100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3L21_RS15105	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C3L21_RS15110	COG0527	aspartate kinase activity
C3L21_RS15120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3L21_RS15130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3L21_RS15145	COG2226	methyltransferase
C3L21_RS15160	COG0494	nUDIX hydrolase
C3L21_RS15170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3L21_RS15175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3L21_RS15180	COG0653	protein targeting
C3L21_RS15200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3L21_RS15235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3L21_RS15245	COG0300	oxidoreductase activity
C3L21_RS15255	COG2096	Adenosyltransferase
C3L21_RS15270	COG2086	electron transfer activity
C3L21_RS15275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3L21_RS15280	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3L21_RS15285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3L21_RS15290	COG0165	Argininosuccinate lyase
C3L21_RS15310	COG3385	transposase activity
C3L21_RS15330	COG2884	Cell division ATP-binding protein ftsE
C3L21_RS15350	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C3L21_RS15360	COG0287	Prephenate dehydrogenase
C3L21_RS15365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3L21_RS15370	COG2226	methyltransferase
C3L21_RS15375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3L21_RS15395	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3L21_RS15400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C3L21_RS15430	COG4536	flavin adenine dinucleotide binding
C3L21_RS15435	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3L21_RS15440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3L21_RS15450	COG3609	addiction module antidote protein, CC2985 family
C3L21_RS15460	COG4974	Belongs to the 'phage' integrase family
C3L21_RS15465	COG0825	malonyl-CoA metabolic process
C3L21_RS15470	COG3034	peptidoglycan biosynthetic process
C3L21_RS15490	COG0523	cobalamin synthesis protein
C3L21_RS15495	COG1686	Belongs to the peptidase S11 family
C3L21_RS15500	COG1473	amidohydrolase
C3L21_RS15510	COG1064	alcohol dehydrogenase
C3L21_RS15515	COG2207	Transcriptional regulator
C3L21_RS15520	COG1522	sequence-specific DNA binding
C3L21_RS15525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3L21_RS15530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS15535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3L21_RS15545	COG0402	S-adenosylhomocysteine deaminase activity
C3L21_RS15555	COG4176	ABC-type proline glycine betaine transport system permease component
C3L21_RS15560	COG4175	Glycine betaine
C3L21_RS15560	COG0517	IMP dehydrogenase activity
C3L21_RS15565	COG2986	histidine ammonia-lyase
C3L21_RS15630	COG0482	sulfurtransferase activity
C3L21_RS15690	COG0564	pseudouridine synthase activity
C3L21_RS15695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3L21_RS15705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3L21_RS15715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3L21_RS15735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3L21_RS15740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3L21_RS15745	COG0037	tRNA processing
C3L21_RS15755	COG2885	chlorophyll binding
C3L21_RS15760	COG0823	Involved in the tonB-independent uptake of proteins
C3L21_RS15785	COG0824	Thioesterase
C3L21_RS15810	COG2255	four-way junction helicase activity
C3L21_RS15815	COG0632	four-way junction helicase activity
C3L21_RS15820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3L21_RS15825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3L21_RS15830	COG0217	transcriptional regulatory protein
C3L21_RS15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS15850	COG1692	metallophosphoesterase
C3L21_RS15900	COG0126	phosphoglycerate kinase activity
C3L21_RS15905	COG3588	fructose-bisphosphate aldolase
C3L21_RS15910	COG0384	phenazine biosynthesis protein PhzF
C3L21_RS15940	COG0254	rRNA binding
C3L21_RS15945	COG1132	(ABC) transporter
C3L21_RS15960	COG0483	inositol monophosphate 1-phosphatase activity
C3L21_RS15980	COG0640	Transcriptional regulator
C3L21_RS15995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3L21_RS16000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C3L21_RS16005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3L21_RS16010	COG0457	Tetratricopeptide repeat
C3L21_RS16015	COG0469	pyruvate kinase activity
C3L21_RS16035	COG3750	Belongs to the UPF0335 family
C3L21_RS16040	COG3108	Peptidase M15
C3L21_RS16055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3L21_RS16065	COG0745	RESPONSE REGULATOR receiver
C3L21_RS16065	COG3706	GGDEF domain
C3L21_RS16070	COG5310	Homospermidine synthase
C3L21_RS16080	COG0737	Belongs to the 5'-nucleotidase family
C3L21_RS16085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3L21_RS16095	COG1585	Membrane protein implicated in regulation of membrane protease activity
C3L21_RS16105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3L21_RS16110	COG2951	lytic endotransglycosylase activity
C3L21_RS16125	COG0069	glutamate synthase activity
C3L21_RS16125	COG0067	glutamate synthase
C3L21_RS16125	COG0070	glutamate synthase
C3L21_RS16145	COG2197	response regulator
C3L21_RS16150	COG2267	carboxylic ester hydrolase activity
C3L21_RS16155	COG0601	transmembrane transport
C3L21_RS16160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS16165	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS16175	COG0071	Belongs to the small heat shock protein (HSP20) family
C3L21_RS16205	COG0129	dihydroxy-acid dehydratase activity
C3L21_RS16260	COG0583	DNA-binding transcription factor activity
C3L21_RS16265	COG0667	Aldo Keto reductase
C3L21_RS16275	COG1305	Transglutaminase-like
C3L21_RS16285	COG0058	SHG alpha-glucan phosphorylase activity
C3L21_RS16290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3L21_RS16295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3L21_RS16300	COG0297	glycogen (starch) synthase activity
C3L21_RS16305	COG0033	Phosphoglucomutase
C3L21_RS16310	COG1523	belongs to the glycosyl hydrolase 13 family
C3L21_RS16335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3L21_RS16335	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3L21_RS16345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS16350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3L21_RS16370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C3L21_RS16375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3L21_RS16380	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3L21_RS16390	COG5001	Diguanylate cyclase
C3L21_RS16395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3L21_RS16400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3L21_RS16405	COG1609	Transcriptional regulator
C3L21_RS16410	COG1846	Transcriptional regulator
C3L21_RS16420	COG0523	cobalamin synthesis protein
C3L21_RS16435	COG1280	lysine exporter protein (LysE YggA)
C3L21_RS16450	COG0583	DNA-binding transcription factor activity
C3L21_RS16460	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C3L21_RS16490	COG0800	Aldolase
C3L21_RS16515	COG2011	ABC-type metal ion transport system permease component
C3L21_RS16520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3L21_RS16530	COG0673	inositol 2-dehydrogenase activity
C3L21_RS16540	COG2115	Belongs to the xylose isomerase family
C3L21_RS16545	COG1070	Carbohydrate kinase
C3L21_RS16570	COG1309	transcriptional regulator
C3L21_RS16575	COG2207	Transcriptional regulator
C3L21_RS16575	COG3708	Transcriptional regulator
C3L21_RS16580	COG1253	flavin adenine dinucleotide binding
C3L21_RS16585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3L21_RS16590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3L21_RS16600	COG1957	nucleoside hydrolase
C3L21_RS16610	COG1793	dna ligase
C3L21_RS16610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C3L21_RS16620	COG2111	Na H antiporter
C3L21_RS16620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3L21_RS16625	COG1006	Multisubunit Na H antiporter MnhC subunit
C3L21_RS16630	COG0651	ATP synthesis coupled electron transport
C3L21_RS16635	COG1863	multisubunit Na H antiporter MnhE subunit
C3L21_RS16640	COG2212	antiporter activity
C3L21_RS16645	COG1320	monovalent cation:proton antiporter activity
C3L21_RS16655	COG0583	DNA-binding transcription factor activity
C3L21_RS16700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3L21_RS16705	COG0725	ABC transporter, periplasmic molybdate-binding protein
C3L21_RS16715	COG4149	molybdate abc transporter
C3L21_RS16720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C3L21_RS16725	COG3585	molybdate ion transport
C3L21_RS16725	COG2005	Transcriptional regulator
C3L21_RS16740	COG0022	dehydrogenase e1 component
C3L21_RS16765	COG0625	glutathione transferase activity
C3L21_RS16775	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C3L21_RS16795	COG2197	response regulator
C3L21_RS16820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS16845	COG3300	MHYT domain
C3L21_RS16845	COG5001	Diguanylate cyclase
C3L21_RS16850	COG1802	Transcriptional regulator
C3L21_RS16860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3L21_RS16875	COG1126	abc transporter atp-binding protein
C3L21_RS16890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS16895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS16905	COG0584	glycerophosphoryl diester phosphodiesterase
C3L21_RS16910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS16930	COG0747	negative chemotaxis
C3L21_RS16935	COG2390	Transcriptional regulator
C3L21_RS16985	COG0410	ABC transporter
C3L21_RS16990	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS17005	COG3328	transposase activity
C3L21_RS17015	COG2942	2-epimerase
C3L21_RS17020	COG4702	Belongs to the UPF0303 family
C3L21_RS17025	COG1940	carbohydrate kinase activity
C3L21_RS17055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3L21_RS17060	COG0156	8-amino-7-oxononanoate synthase activity
C3L21_RS17095	COG2267	carboxylic ester hydrolase activity
C3L21_RS17135	COG0835	chemotaxis
C3L21_RS17150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3L21_RS17155	COG3383	formate dehydrogenase (NAD+) activity
C3L21_RS17175	COG0583	DNA-binding transcription factor activity
C3L21_RS17195	COG3842	ATPase activity
C3L21_RS17200	COG3842	ATPase activity
C3L21_RS17210	COG0395	ABC-type sugar transport system, permease component
C3L21_RS17225	COG2233	PERMEase
C3L21_RS17230	COG2233	PERMEase
C3L21_RS17245	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3L21_RS17250	COG1121	(ABC) transporter
C3L21_RS17255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3L21_RS17260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3L21_RS17280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3L21_RS17285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3L21_RS17290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3L21_RS17295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3L21_RS17300	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3L21_RS17315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3L21_RS17335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3L21_RS17345	COG4974	Belongs to the 'phage' integrase family
C3L21_RS17360	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS17375	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3L21_RS17380	COG0567	Dehydrogenase, E1 component
C3L21_RS17385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C3L21_RS17390	COG0045	succinate-CoA ligase (ADP-forming) activity
C3L21_RS17395	COG0039	L-malate dehydrogenase activity
C3L21_RS17400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C3L21_RS17410	COG3549	Plasmid maintenance system killer
C3L21_RS17415	COG2845	Protein of unknown function (DUF459)
C3L21_RS17425	COG0395	ABC-type sugar transport system, permease component
C3L21_RS17430	COG1175	transmembrane transport
C3L21_RS17455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3L21_RS17475	COG2009	succinate dehydrogenase
C3L21_RS17500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3L21_RS17505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3L21_RS17510	COG0181	hydroxymethylbilane synthase activity
C3L21_RS17535	COG0519	Catalyzes the synthesis of GMP from XMP
C3L21_RS17535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3L21_RS17550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3L21_RS17575	COG4249	Peptidase C14 caspase catalytic subunit p20
C3L21_RS17605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3L21_RS17610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3L21_RS17625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3L21_RS17630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3L21_RS17635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3L21_RS17640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3L21_RS17645	COG0799	negative regulation of ribosome biogenesis
C3L21_RS17650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C3L21_RS17660	COG0793	Belongs to the peptidase S41A family
C3L21_RS17665	COG2861	carbohydrate metabolic process
C3L21_RS17670	COG0494	nUDIX hydrolase
C3L21_RS17685	COG0587	DNA-directed DNA polymerase activity
C3L21_RS17690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3L21_RS17705	COG2301	Belongs to the HpcH HpaI aldolase family
C3L21_RS17715	COG0066	3-isopropylmalate dehydratase activity
C3L21_RS17720	COG0251	oxidation-reduction process
C3L21_RS17725	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C3L21_RS17735	COG0523	cobalamin synthesis protein
C3L21_RS17750	COG3118	belongs to the thioredoxin family
C3L21_RS17755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3L21_RS17760	COG2835	tetraacyldisaccharide 4'-kinase activity
C3L21_RS17765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3L21_RS17770	COG1946	Acyl-CoA thioesterase
C3L21_RS17775	COG0347	Belongs to the P(II) protein family
C3L21_RS17780	COG0004	ammonium transporteR
C3L21_RS17785	COG1674	ftsk spoiiie
C3L21_RS17790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C3L21_RS17810	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS17815	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS17820	COG1129	ABC transporter
C3L21_RS17825	COG1940	carbohydrate kinase activity
C3L21_RS17830	COG1940	carbohydrate kinase activity
C3L21_RS17845	COG0745	RESPONSE REGULATOR receiver
C3L21_RS17860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3L21_RS17880	COG0137	argininosuccinate synthase activity
C3L21_RS17890	COG0410	ABC transporter
C3L21_RS17895	COG4120	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS17905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3L21_RS17925	COG2154	pterin-4-alpha-carbinolamine dehydratase
C3L21_RS17930	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C3L21_RS17940	COG4181	ATPase activity
C3L21_RS17950	COG0670	Belongs to the BI1 family
C3L21_RS17960	COG0740	serine-type endopeptidase activity
C3L21_RS17970	COG0640	Transcriptional regulator
C3L21_RS17985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3L21_RS17990	COG4133	protoheme IX ABC transporter activity
C3L21_RS17995	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3L21_RS18000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3L21_RS18020	COG2917	probably involved in intracellular septation
C3L21_RS18025	COG0552	protein localization to endoplasmic reticulum
C3L21_RS18030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3L21_RS18035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3L21_RS18040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3L21_RS18045	COG1605	Chorismate mutase
C3L21_RS18045	COG0287	Prephenate dehydrogenase
C3L21_RS18050	COG0228	four-way junction DNA binding
C3L21_RS18055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3L21_RS18060	COG0336	Belongs to the RNA methyltransferase TrmD family
C3L21_RS18070	COG0335	large ribosomal subunit rRNA binding
C3L21_RS18080	COG0765	amino acid transport
C3L21_RS18110	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C3L21_RS18115	COG4783	chaperone-mediated protein folding
C3L21_RS18120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3L21_RS18125	COG1329	Transcriptional regulator
C3L21_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS18150	COG0183	Belongs to the thiolase family
C3L21_RS18155	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C3L21_RS18160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3L21_RS18165	COG0625	glutathione transferase activity
C3L21_RS18170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3L21_RS18175	COG0142	geranyltranstransferase activity
C3L21_RS18180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3L21_RS18190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3L21_RS18195	COG2223	nitrite transmembrane transporter activity
C3L21_RS18205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS18210	COG0765	amino acid transport
C3L21_RS18215	COG1126	abc transporter atp-binding protein
C3L21_RS18220	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3L21_RS18230	COG1132	(ABC) transporter
C3L21_RS18245	COG3459	Glycosyltransferase 36 associated
C3L21_RS18260	COG5383	Protein conserved in bacteria
C3L21_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS18310	COG3842	ATPase activity
C3L21_RS18325	COG1653	transport
C3L21_RS18330	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS18335	COG1024	Enoyl-CoA hydratase
C3L21_RS18345	COG0673	inositol 2-dehydrogenase activity
C3L21_RS18350	COG1609	Transcriptional regulator
C3L21_RS18360	COG0339	signal peptide processing
C3L21_RS18370	COG0473	3-isopropylmalate dehydrogenase activity
C3L21_RS18375	COG0671	phosphoesterase, PA-phosphatase related
C3L21_RS18400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3L21_RS18410	COG0288	reversible hydration of carbon dioxide
C3L21_RS18420	COG2902	Dehydrogenase
C3L21_RS18430	COG0138	bifunctional purine biosynthesis protein purh
C3L21_RS18445	COG0501	Belongs to the peptidase M48B family
C3L21_RS18455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3L21_RS18475	COG0495	leucyl-tRNA aminoacylation
C3L21_RS18490	COG1475	DNA binding
C3L21_RS18495	COG1192	Involved in chromosome partitioning
C3L21_RS18500	COG0357	Ribosomal RNA small subunit methyltransferase G
C3L21_RS18505	COG0445	tRNA wobble uridine modification
C3L21_RS18510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3L21_RS18515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C3L21_RS18525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3L21_RS18530	COG1192	Involved in chromosome partitioning
C3L21_RS18535	COG1475	DNA binding
C3L21_RS18540	COG1414	Transcriptional regulator
C3L21_RS18545	COG1764	response to oxidative stress
C3L21_RS18555	COG0488	(ABC) transporter
C3L21_RS18565	COG1309	transcriptional regulator
C3L21_RS18595	COG0402	S-adenosylhomocysteine deaminase activity
C3L21_RS18625	COG0730	response to heat
C3L21_RS18655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS18660	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3L21_RS18665	COG2080	2 iron, 2 sulfur cluster binding
C3L21_RS18685	COG4221	oxidoreductase activity
C3L21_RS18720	COG2205	protein histidine kinase activity
C3L21_RS18760	COG4251	negative regulation of phosphorylation
C3L21_RS18760	COG5001	Diguanylate cyclase
C3L21_RS18760	COG3706	GGDEF domain
C3L21_RS18760	COG2203	Gaf domain
C3L21_RS18795	COG1902	pentaerythritol trinitrate reductase activity
C3L21_RS18800	COG0251	oxidation-reduction process
C3L21_RS18805	COG0583	DNA-binding transcription factor activity
C3L21_RS18890	COG4467	Involved in initiation control of chromosome replication
C3L21_RS18900	COG4467	Involved in initiation control of chromosome replication
C3L21_RS18925	COG0210	DNA helicase
C3L21_RS18945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3L21_RS18955	COG3415	Transposase
C3L21_RS18970	COG1484	DNA-dependent DNA replication
C3L21_RS18985	COG0443	Heat shock 70 kDa protein
C3L21_RS19005	COG1278	Cold shock
C3L21_RS19020	COG0765	amino acid transport
C3L21_RS19025	COG0765	amino acid transport
C3L21_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS19045	COG2186	Transcriptional regulator
C3L21_RS19050	COG0473	3-isopropylmalate dehydrogenase activity
C3L21_RS19050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3L21_RS19055	COG1069	ribulokinase activity
C3L21_RS19065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3L21_RS19085	COG1278	Cold shock
C3L21_RS19125	COG4584	PFAM Integrase catalytic
C3L21_RS19140	COG1733	regulation of RNA biosynthetic process
C3L21_RS19160	COG0583	DNA-binding transcription factor activity
C3L21_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS19180	COG1063	alcohol dehydrogenase
C3L21_RS19190	COG0583	DNA-binding transcription factor activity
C3L21_RS19200	COG0604	alcohol dehydrogenase
C3L21_RS19220	COG0667	Aldo Keto reductase
C3L21_RS19230	COG0673	inositol 2-dehydrogenase activity
C3L21_RS19235	COG0745	RESPONSE REGULATOR receiver
C3L21_RS19240	COG0642	Histidine kinase
C3L21_RS19265	COG0583	DNA-binding transcription factor activity
C3L21_RS19315	COG3077	Addiction module antitoxin, RelB DinJ family
C3L21_RS19345	COG2423	ornithine cyclodeaminase activity
C3L21_RS19350	COG1126	abc transporter atp-binding protein
C3L21_RS19360	COG4215	(ABC) transporter
C3L21_RS19385	COG0765	amino acid transport
C3L21_RS19390	COG0765	amino acid transport
C3L21_RS19405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3L21_RS19410	COG1063	alcohol dehydrogenase
C3L21_RS19415	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS19420	COG3265	gluconokinase activity
C3L21_RS19425	COG2084	Dehydrogenase
C3L21_RS19450	COG3842	ATPase activity
C3L21_RS19460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3L21_RS19550	COG2186	Transcriptional regulator
C3L21_RS19560	COG1126	abc transporter atp-binding protein
C3L21_RS19575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS19595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3L21_RS19600	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS19635	COG0251	oxidation-reduction process
C3L21_RS19640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3L21_RS19695	COG0667	Aldo Keto reductase
C3L21_RS19700	COG2133	pyrroloquinoline quinone binding
C3L21_RS19710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3L21_RS19755	COG4221	oxidoreductase activity
C3L21_RS19840	COG4191	Histidine kinase
C3L21_RS19840	COG0784	Response regulator, receiver
C3L21_RS19865	COG0628	permease
C3L21_RS19880	COG3237	CsbD-like
C3L21_RS19895	COG3321	synthase
C3L21_RS19895	COG0604	alcohol dehydrogenase
C3L21_RS19895	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS19920	COG4977	sequence-specific DNA binding
C3L21_RS19920	COG1917	Cupin 2, conserved barrel domain protein
C3L21_RS19935	COG3609	addiction module antidote protein, CC2985 family
C3L21_RS19965	COG4221	oxidoreductase activity
C3L21_RS19995	COG1802	Transcriptional regulator
C3L21_RS20000	COG1063	alcohol dehydrogenase
C3L21_RS20025	COG0411	ABC transporter
C3L21_RS20030	COG0410	ABC transporter
C3L21_RS20035	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS20040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3L21_RS20045	COG0277	FAD linked oxidase domain protein
C3L21_RS20105	COG0251	oxidation-reduction process
C3L21_RS20125	COG1414	Transcriptional regulator
C3L21_RS20135	COG0477	Major facilitator Superfamily
C3L21_RS20140	COG0028	Belongs to the TPP enzyme family
C3L21_RS20145	COG2855	membrane
C3L21_RS20160	COG0583	DNA-binding transcription factor activity
C3L21_RS20165	COG4638	Rieske (2fe-2S)
C3L21_RS20180	COG2267	carboxylic ester hydrolase activity
C3L21_RS20190	COG2267	carboxylic ester hydrolase activity
C3L21_RS20195	COG1309	transcriptional regulator
C3L21_RS20210	COG1484	DNA-dependent DNA replication
C3L21_RS20230	COG0583	DNA-binding transcription factor activity
C3L21_RS20235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C3L21_RS20240	COG0747	negative chemotaxis
C3L21_RS20245	COG0601	transmembrane transport
C3L21_RS20255	COG0444	Belongs to the ABC transporter superfamily
C3L21_RS20320	COG1278	Cold shock
C3L21_RS20330	COG3239	Fatty acid desaturase
C3L21_RS20350	COG0628	permease
C3L21_RS20355	COG3300	MHYT domain
C3L21_RS20355	COG5001	Diguanylate cyclase
C3L21_RS20365	COG1404	Belongs to the peptidase S8 family
C3L21_RS20390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3L21_RS20395	COG0318	PFAM AMP-dependent synthetase and ligase
C3L21_RS20415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS20420	COG1802	Transcriptional regulator
C3L21_RS20425	COG4964	Belongs to the GSP D family
C3L21_RS20445	COG2226	methyltransferase
C3L21_RS20470	COG0583	DNA-binding transcription factor activity
C3L21_RS20480	COG1278	Cold shock
C3L21_RS20485	COG0477	Major facilitator Superfamily
C3L21_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS20530	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS20535	COG1129	ABC transporter
C3L21_RS20540	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS20545	COG4585	Histidine kinase
C3L21_RS20575	COG1129	ABC transporter
C3L21_RS20590	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS20595	COG1802	Transcriptional regulator
C3L21_RS20615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3L21_RS20620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3L21_RS20630	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C3L21_RS20635	COG0129	dihydroxy-acid dehydratase activity
C3L21_RS20640	COG2084	Dehydrogenase
C3L21_RS20645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS20650	COG0277	FAD linked oxidase domain protein
C3L21_RS20655	COG2186	Transcriptional regulator
C3L21_RS20665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C3L21_RS20670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS20675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS20705	COG1454	alcohol dehydrogenase
C3L21_RS20710	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C3L21_RS20715	COG1802	Transcriptional regulator
C3L21_RS20720	COG1129	ABC transporter
C3L21_RS20725	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS20730	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS20735	COG0693	protein deglycase activity
C3L21_RS20770	COG4634	DNA integration
C3L21_RS20780	COG2963	transposase activity
C3L21_RS20790	COG4372	Transposase
C3L21_RS20795	COG2442	InterPro IPR007367
C3L21_RS20855	COG1086	Polysaccharide biosynthesis protein
C3L21_RS20860	COG0583	DNA-binding transcription factor activity
C3L21_RS20865	COG3177	Filamentation induced by cAMP protein fic
C3L21_RS20880	COG2910	NAD(P)H-binding
C3L21_RS20885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3L21_RS20900	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS20910	COG0601	transmembrane transport
C3L21_RS20915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS20930	COG0667	Aldo Keto reductase
C3L21_RS20955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C3L21_RS20970	COG3920	Histidine kinase
C3L21_RS20975	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C3L21_RS20995	COG1116	anion transmembrane transporter activity
C3L21_RS21005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3L21_RS21035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3L21_RS21065	COG0625	glutathione transferase activity
C3L21_RS21115	COG3278	Belongs to the heme-copper respiratory oxidase family
C3L21_RS21130	COG2010	Cytochrome c
C3L21_RS21165	COG2885	chlorophyll binding
C3L21_RS21165	COG3047	cAMP biosynthetic process
C3L21_RS21185	COG0668	transmembrane transport
C3L21_RS21205	COG0517	IMP dehydrogenase activity
C3L21_RS21310	COG0628	permease
C3L21_RS21345	COG0531	amino acid
C3L21_RS21350	COG1982	Orn Lys Arg decarboxylase major
C3L21_RS21365	COG0531	amino acid
C3L21_RS21420	COG3734	2-keto-3-deoxy-galactonokinase
C3L21_RS21430	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS21440	COG1175	transmembrane transport
C3L21_RS21445	COG0395	ABC-type sugar transport system, permease component
C3L21_RS21460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS21470	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS21495	COG3328	transposase activity
C3L21_RS21525	COG1278	Cold shock
C3L21_RS21555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3L21_RS21655	COG3831	ATPase activity
C3L21_RS21660	COG3547	Transposase (IS116 IS110 IS902 family)
C3L21_RS21715	COG0582	viral genome integration into host DNA
C3L21_RS21720	COG0582	viral genome integration into host DNA
C3L21_RS21725	COG0582	viral genome integration into host DNA
C3L21_RS21740	COG4372	Transposase
C3L21_RS21775	COG4372	Transposase
C3L21_RS21785	COG2963	transposase activity
C3L21_RS21805	COG1278	Cold shock
C3L21_RS21825	COG3328	transposase activity
C3L21_RS21835	COG1192	Involved in chromosome partitioning
C3L21_RS21855	COG2124	cytochrome p450
C3L21_RS21860	COG2124	cytochrome p450
C3L21_RS21885	COG3316	Transposase and inactivated derivatives
C3L21_RS21890	COG0598	Magnesium transport protein CorA
C3L21_RS21895	COG4957	zinc ion binding
C3L21_RS21900	COG2197	response regulator
C3L21_RS21960	COG1522	sequence-specific DNA binding
C3L21_RS21980	COG2022	thiamine diphosphate biosynthetic process
C3L21_RS21995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3L21_RS22000	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C3L21_RS22055	COG5001	Diguanylate cyclase
C3L21_RS22070	COG1396	sequence-specific DNA binding
C3L21_RS22095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3L21_RS22100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3L21_RS22185	COG4584	PFAM Integrase catalytic
C3L21_RS22190	COG1484	DNA-dependent DNA replication
C3L21_RS22215	COG1278	Cold shock
C3L21_RS22235	COG1115	amino acid carrier protein
C3L21_RS22265	COG2226	methyltransferase
C3L21_RS22270	COG0583	DNA-binding transcription factor activity
C3L21_RS22300	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C3L21_RS22320	COG4372	Transposase
C3L21_RS22360	COG0601	transmembrane transport
C3L21_RS22365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS22375	COG4608	Belongs to the ABC transporter superfamily
C3L21_RS22385	COG1484	DNA-dependent DNA replication
C3L21_RS22400	COG3415	Transposase
C3L21_RS22410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3L21_RS22495	COG2010	Cytochrome c
C3L21_RS22530	COG4584	PFAM Integrase catalytic
C3L21_RS22535	COG1484	DNA-dependent DNA replication
C3L21_RS22550	COG2963	transposase activity
C3L21_RS22580	COG2267	carboxylic ester hydrolase activity
C3L21_RS22590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3L21_RS22595	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS22610	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS22615	COG0395	ABC-type sugar transport system, permease component
C3L21_RS22710	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C3L21_RS22715	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C3L21_RS22725	COG1433	Dinitrogenase iron-molybdenum cofactor
C3L21_RS22735	COG3383	formate dehydrogenase (NAD+) activity
C3L21_RS22755	COG2963	transposase activity
C3L21_RS22760	COG3436	PFAM IS66 Orf2 family protein
C3L21_RS22765	COG2433	Pfam Transposase IS66
C3L21_RS22805	COG2963	transposase activity
C3L21_RS22810	COG3436	PFAM IS66 Orf2 family protein
C3L21_RS22815	COG4372	Transposase
C3L21_RS22845	COG0175	sulfate reduction
C3L21_RS22850	COG2895	sulfate adenylyltransferase (ATP) activity
C3L21_RS22850	COG0529	Catalyzes the synthesis of activated sulfate
C3L21_RS22915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3L21_RS23040	COG3505	Type IV secretory pathway VirD4
C3L21_RS23060	COG0668	transmembrane transport
C3L21_RS23090	COG4566	intracellular signal transduction
C3L21_RS23095	COG4566	intracellular signal transduction
C3L21_RS23100	COG3119	arylsulfatase activity
C3L21_RS23115	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3L21_RS23120	COG2843	Capsule synthesis protein
C3L21_RS23135	COG0601	transmembrane transport
C3L21_RS23175	COG2197	response regulator
C3L21_RS23200	COG0583	DNA-binding transcription factor activity
C3L21_RS23220	COG2801	Transposase and inactivated derivatives
C3L21_RS23225	COG2801	Transposase and inactivated derivatives
C3L21_RS23320	COG1063	alcohol dehydrogenase
C3L21_RS23545	COG3005	denitrification pathway
C3L21_RS23570	COG4459	periplasmic nitrate reductase
C3L21_RS23580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3L21_RS23605	COG2151	metal-sulfur cluster biosynthetic enzyme
C3L21_RS23635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3L21_RS23640	COG3344	reverse transcriptase
C3L21_RS23650	COG0714	Associated with various cellular activities
C3L21_RS23655	COG3256	nitric oxide reductase
C3L21_RS23670	COG1845	cytochrome c oxidase, subunit III
C3L21_RS23690	COG0163	prenyltransferase activity
C3L21_RS23695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C3L21_RS23730	COG1309	transcriptional regulator
C3L21_RS23735	COG2814	Major facilitator Superfamily
C3L21_RS23740	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C3L21_RS23745	COG2948	multi-organism process
C3L21_RS23750	COG3504	Conjugal transfer protein
C3L21_RS23755	COG3736	Type IV secretory pathway, component VirB8
C3L21_RS23765	COG3704	protein secretion by the type IV secretion system
C3L21_RS23780	COG3451	type IV secretory pathway VirB4
C3L21_RS23785	COG3702	type iv secretory pathway
C3L21_RS23790	COG3838	Conjugal transfer protein Trbc
C3L21_RS23825	COG0477	Major facilitator Superfamily
C3L21_RS23830	COG0024	Methionine aminopeptidase
C3L21_RS23840	COG5564	TIM-barrel signal transduction protein
C3L21_RS23860	COG1175	transmembrane transport
C3L21_RS23875	COG3842	ATPase activity
C3L21_RS23880	COG3842	ATPase activity
C3L21_RS23885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3L21_RS23895	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS23900	COG1082	Xylose isomerase domain protein TIM barrel
C3L21_RS23905	COG1082	Xylose isomerase domain protein TIM barrel
C3L21_RS23925	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C3L21_RS23930	COG4974	Belongs to the 'phage' integrase family
C3L21_RS23950	COG0395	ABC-type sugar transport system, permease component
C3L21_RS23955	COG1175	transmembrane transport
C3L21_RS23970	COG0444	Belongs to the ABC transporter superfamily
C3L21_RS23985	COG4608	Belongs to the ABC transporter superfamily
C3L21_RS23990	COG0444	Belongs to the ABC transporter superfamily
C3L21_RS23995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS24000	COG0601	transmembrane transport
C3L21_RS24010	COG0154	amidase activity
C3L21_RS24020	COG0747	negative chemotaxis
C3L21_RS24045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3L21_RS24050	COG2086	electron transfer activity
C3L21_RS24070	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS24085	COG1024	Enoyl-CoA hydratase
C3L21_RS24095	COG0656	L-ascorbic acid biosynthetic process
C3L21_RS24115	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS24125	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS24130	COG1129	ABC transporter
C3L21_RS24135	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS24145	COG1309	transcriptional regulator
C3L21_RS24150	COG1063	alcohol dehydrogenase
C3L21_RS24160	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS24170	COG0601	transmembrane transport
C3L21_RS24175	COG0747	negative chemotaxis
C3L21_RS24185	COG2186	Transcriptional regulator
C3L21_RS24195	COG0477	Major facilitator Superfamily
C3L21_RS24205	COG0183	Belongs to the thiolase family
C3L21_RS24235	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS24260	COG1335	isochorismatase
C3L21_RS24265	COG0006	proline dipeptidase activity
C3L21_RS24275	COG5598	trimethylamine methyltransferase
C3L21_RS24325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3L21_RS24330	COG0625	glutathione transferase activity
C3L21_RS24350	COG1802	Transcriptional regulator
C3L21_RS24360	COG1129	ABC transporter
C3L21_RS24450	COG0651	ATP synthesis coupled electron transport
C3L21_RS24460	COG0839	Belongs to the complex I subunit 6 family
C3L21_RS24465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3L21_RS24470	COG5001	Diguanylate cyclase
C3L21_RS24490	COG0840	transmembrane signaling receptor activity
C3L21_RS24495	COG0643	Histidine kinase
C3L21_RS24495	COG2198	Histidine kinase
C3L21_RS24530	COG0489	protein tyrosine kinase activity
C3L21_RS24555	COG3264	Mechanosensitive ion channel
C3L21_RS24555	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C3L21_RS24600	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3L21_RS24600	COG1672	PFAM Archaeal ATPase
C3L21_RS24635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3L21_RS24635	COG4651	solute:proton antiporter activity
C3L21_RS24645	COG1902	pentaerythritol trinitrate reductase activity
C3L21_RS24665	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS24675	COG0583	DNA-binding transcription factor activity
C3L21_RS24680	COG2963	transposase activity
C3L21_RS24690	COG4372	Transposase
C3L21_RS24715	COG2814	Major facilitator Superfamily
C3L21_RS24745	COG0444	Belongs to the ABC transporter superfamily
C3L21_RS24750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS24755	COG0601	transmembrane transport
C3L21_RS24770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3L21_RS24845	COG0628	permease
C3L21_RS24875	COG3119	arylsulfatase activity
C3L21_RS24895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3L21_RS24960	COG2252	PERMEase
C3L21_RS24970	COG0583	DNA-binding transcription factor activity
C3L21_RS24975	COG1335	isochorismatase
C3L21_RS24985	COG1309	transcriptional regulator
C3L21_RS25020	COG0583	DNA-binding transcription factor activity
C3L21_RS25045	COG4372	Transposase
C3L21_RS25060	COG1120	ATPase activity
C3L21_RS25065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3L21_RS25070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3L21_RS25100	COG1177	transmembrane transport
C3L21_RS25105	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS25110	COG3842	ATPase activity
C3L21_RS25120	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS25125	COG1802	Transcriptional regulator
C3L21_RS25135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3L21_RS25150	COG0346	lactoylglutathione lyase activity
C3L21_RS25185	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS25200	COG3328	transposase activity
C3L21_RS25225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C3L21_RS25225	COG1672	PFAM Archaeal ATPase
C3L21_RS25275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C3L21_RS25280	COG2814	Major facilitator Superfamily
C3L21_RS25290	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C3L21_RS25300	COG1335	isochorismatase
C3L21_RS25310	COG2207	Transcriptional regulator
C3L21_RS25355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3L21_RS25365	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS25370	COG0473	3-isopropylmalate dehydrogenase activity
C3L21_RS25375	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS25380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS25390	COG0454	-acetyltransferase
C3L21_RS25410	COG0601	transmembrane transport
C3L21_RS25415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS25425	COG1522	sequence-specific DNA binding
C3L21_RS25445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3L21_RS25470	COG3278	Belongs to the heme-copper respiratory oxidase family
C3L21_RS25480	COG0459	protein refolding
C3L21_RS25485	COG0156	8-amino-7-oxononanoate synthase activity
C3L21_RS25490	COG1999	signal sequence binding
C3L21_RS25510	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3L21_RS25530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS25540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3L21_RS25555	COG1309	transcriptional regulator
C3L21_RS25570	COG0583	DNA-binding transcription factor activity
C3L21_RS25640	COG0471	metal ion transport
C3L21_RS25640	COG3273	potassium ion transport
C3L21_RS25800	COG2814	Major facilitator Superfamily
C3L21_RS25815	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C3L21_RS25825	COG0583	DNA-binding transcription factor activity
C3L21_RS25860	COG0235	Class ii aldolase
C3L21_RS25870	COG0583	DNA-binding transcription factor activity
C3L21_RS25905	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS25910	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS25915	COG1129	ABC transporter
C3L21_RS25920	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS25930	COG1940	carbohydrate kinase activity
C3L21_RS25940	COG1309	transcriptional regulator
C3L21_RS25985	COG1846	Transcriptional regulator
C3L21_RS26005	COG1335	isochorismatase
C3L21_RS26020	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS26025	COG1278	Cold shock
C3L21_RS26045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3L21_RS26060	COG0251	oxidation-reduction process
C3L21_RS26070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3L21_RS26075	COG1126	abc transporter atp-binding protein
C3L21_RS26080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3L21_RS26090	COG0765	amino acid transport
C3L21_RS26095	COG1609	Transcriptional regulator
C3L21_RS26105	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS26125	COG1802	Transcriptional regulator
C3L21_RS26135	COG2186	Transcriptional regulator
C3L21_RS26150	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS26160	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS26180	COG0583	DNA-binding transcription factor activity
C3L21_RS26185	COG0488	(ABC) transporter
C3L21_RS26210	COG1305	Transglutaminase-like
C3L21_RS26280	COG2864	formate dehydrogenase
C3L21_RS26285	COG0437	4 iron, 4 sulfur cluster binding
C3L21_RS26295	COG1192	Involved in chromosome partitioning
C3L21_RS26300	COG1475	DNA binding
C3L21_RS26305	COG1414	Transcriptional regulator
C3L21_RS26325	COG0697	spore germination
C3L21_RS26330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS26335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3L21_RS26340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS26345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS26350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C3L21_RS26355	COG1309	transcriptional regulator
C3L21_RS26370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3L21_RS26385	COG4372	Transposase
C3L21_RS26435	COG1522	sequence-specific DNA binding
C3L21_RS26440	COG0022	dehydrogenase e1 component
C3L21_RS26445	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3L21_RS26455	COG1129	ABC transporter
C3L21_RS26460	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS26465	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS26470	COG1609	Transcriptional regulator
C3L21_RS26495	COG0583	DNA-binding transcription factor activity
C3L21_RS26500	COG1793	dna ligase
C3L21_RS26505	COG0753	catalase activity
C3L21_RS26515	COG0625	glutathione transferase activity
C3L21_RS26525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3L21_RS26575	COG1486	melibiose metabolic process
C3L21_RS26580	COG0747	negative chemotaxis
C3L21_RS26585	COG0601	transmembrane transport
C3L21_RS26590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS26595	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS26600	COG1486	melibiose metabolic process
C3L21_RS26615	COG3396	Phenylacetate-CoA oxygenase
C3L21_RS26620	COG3460	Phenylacetate-CoA oxygenase
C3L21_RS26625	COG3396	Phenylacetate-CoA oxygenase
C3L21_RS26630	COG2151	metal-sulfur cluster biosynthetic enzyme
C3L21_RS26635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3L21_RS26640	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS26640	COG2030	dehydratase
C3L21_RS26645	COG1607	acyl-coa hydrolase
C3L21_RS26650	COG1024	Enoyl-CoA hydratase
C3L21_RS26655	COG1024	Enoyl-CoA hydratase
C3L21_RS26655	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3L21_RS26660	COG0019	diaminopimelate decarboxylase activity
C3L21_RS26680	COG1175	transmembrane transport
C3L21_RS26705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C3L21_RS26720	COG2814	Major facilitator Superfamily
C3L21_RS26725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C3L21_RS26730	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C3L21_RS26735	COG1129	ABC transporter
C3L21_RS26740	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS26750	COG2390	Transcriptional regulator
C3L21_RS26760	COG2022	thiamine diphosphate biosynthetic process
C3L21_RS26775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3L21_RS26785	COG2204	response regulator
C3L21_RS26790	COG4191	Histidine kinase
C3L21_RS26795	COG1301	dicarboxylic acid transport
C3L21_RS26805	COG0784	Response regulator, receiver
C3L21_RS26805	COG5002	protein histidine kinase activity
C3L21_RS26805	COG2198	Histidine kinase
C3L21_RS26830	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS26840	COG0411	ABC transporter
C3L21_RS26855	COG1475	DNA binding
C3L21_RS26860	COG1192	Involved in chromosome partitioning
C3L21_RS26885	COG1595	DNA-templated transcription, initiation
C3L21_RS26895	COG1254	Belongs to the acylphosphatase family
C3L21_RS26900	COG0183	Belongs to the thiolase family
C3L21_RS26905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3L21_RS26910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C3L21_RS26915	COG1414	Transcriptional regulator
C3L21_RS26925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3L21_RS26945	COG0583	DNA-binding transcription factor activity
C3L21_RS26950	COG2267	carboxylic ester hydrolase activity
C3L21_RS26955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3L21_RS26960	COG3485	protocatechuate 3,4-dioxygenase
C3L21_RS26965	COG3485	protocatechuate 3,4-dioxygenase
C3L21_RS26990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3L21_RS26995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3L21_RS27005	COG0683	leucine binding
C3L21_RS27015	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS27020	COG0411	ABC transporter
C3L21_RS27035	COG3385	transposase activity
C3L21_RS27045	COG0457	Tetratricopeptide repeat
C3L21_RS27055	COG1802	Transcriptional regulator
C3L21_RS27060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C3L21_RS27085	COG2376	Dihydroxyacetone kinase
C3L21_RS27095	COG4778	phosphonate C-P lyase system protein PhnL
C3L21_RS27100	COG4107	phosphonate C-P lyase system protein PhnK
C3L21_RS27105	COG3627	carbon phosphorus lyase activity
C3L21_RS27110	COG3626	phosphonate metabolism
C3L21_RS27115	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C3L21_RS27120	COG3624	Phosphonate C-P lyase system protein PhnG
C3L21_RS27125	COG2188	Transcriptional regulator
C3L21_RS27135	COG0439	Biotin carboxylase
C3L21_RS27140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3L21_RS27145	COG3800	Transcriptional regulator
C3L21_RS27145	COG1396	sequence-specific DNA binding
C3L21_RS27150	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS27155	COG1024	Enoyl-CoA hydratase
C3L21_RS27165	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS27170	COG0246	Mannitol dehydrogenase
C3L21_RS27175	COG1215	transferase activity, transferring glycosyl groups
C3L21_RS27180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3L21_RS27190	COG0174	glutamine synthetase
C3L21_RS27240	COG2205	protein histidine kinase activity
C3L21_RS27245	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS27250	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS27255	COG1129	ABC transporter
C3L21_RS27260	COG1609	Transcriptional regulator
C3L21_RS27275	COG4211	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS27280	COG1129	ABC transporter
C3L21_RS27295	COG2084	Dehydrogenase
C3L21_RS27300	COG2094	Belongs to the DNA glycosylase MPG family
C3L21_RS27305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3L21_RS27325	COG0297	glycogen (starch) synthase activity
C3L21_RS27360	COG4187	Peptidase family M20/M25/M40
C3L21_RS27380	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS27410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3L21_RS27420	COG3257	ureidoglycine aminohydrolase activity
C3L21_RS27425	COG0583	DNA-binding transcription factor activity
C3L21_RS27430	COG1414	Transcriptional regulator
C3L21_RS27435	COG3960	tartronate-semialdehyde synthase activity
C3L21_RS27440	COG3622	Belongs to the hyi family
C3L21_RS27445	COG2084	Dehydrogenase
C3L21_RS27455	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C3L21_RS27480	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS27485	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS27490	COG3395	kinase activity
C3L21_RS27495	COG3622	Belongs to the hyi family
C3L21_RS27500	COG2084	Dehydrogenase
C3L21_RS27505	COG1609	Transcriptional regulator
C3L21_RS27510	COG0235	Class ii aldolase
C3L21_RS27520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS27530	COG3842	ATPase activity
C3L21_RS27540	COG1175	transmembrane transport
C3L21_RS27545	COG0395	ABC-type sugar transport system, permease component
C3L21_RS27555	COG0667	Aldo Keto reductase
C3L21_RS27575	COG0367	asparagine synthase
C3L21_RS27585	COG0318	PFAM AMP-dependent synthetase and ligase
C3L21_RS27590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3L21_RS27600	COG0656	L-ascorbic acid biosynthetic process
C3L21_RS27610	COG0850	regulation of cytokinetic process
C3L21_RS27615	COG2894	cell division
C3L21_RS27620	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C3L21_RS27630	COG2197	response regulator
C3L21_RS27635	COG4585	Histidine kinase
C3L21_RS27650	COG1388	LysM domain
C3L21_RS27650	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS27660	COG2890	protein-(glutamine-N5) methyltransferase activity
C3L21_RS27685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3L21_RS27690	COG1280	lysine exporter protein (LysE YggA)
C3L21_RS27710	COG0297	glycogen (starch) synthase activity
C3L21_RS27715	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS27780	COG3346	SURF1 family
C3L21_RS27785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C3L21_RS27790	COG1845	cytochrome c oxidase, subunit III
C3L21_RS27795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3L21_RS27805	COG0477	Major facilitator Superfamily
C3L21_RS27840	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C3L21_RS27875	COG0300	oxidoreductase activity
C3L21_RS27915	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
C3L21_RS27920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS27925	COG2188	Transcriptional regulator
C3L21_RS27930	COG1486	melibiose metabolic process
C3L21_RS27935	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3L21_RS27935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3L21_RS27940	COG1653	transport
C3L21_RS27945	COG3842	ATPase activity
C3L21_RS27995	COG1573	uracil-dna glycosylase
C3L21_RS28000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3L21_RS28050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS28055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C3L21_RS28060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS28070	COG0583	DNA-binding transcription factor activity
C3L21_RS28080	COG2226	methyltransferase
C3L21_RS28090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3L21_RS28095	COG1120	ATPase activity
C3L21_RS28105	COG2171	N-acyltransferase activity
C3L21_RS28125	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS28130	COG1129	ABC transporter
C3L21_RS28165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3L21_RS28180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3L21_RS28185	COG3189	MarR family transcriptional regulator
C3L21_RS28210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3L21_RS28220	COG1335	isochorismatase
C3L21_RS28300	COG3179	chitinase
C3L21_RS28320	COG3119	arylsulfatase activity
C3L21_RS28395	COG1129	ABC transporter
C3L21_RS28400	COG4214	carbohydrate transport
C3L21_RS28405	COG4213	ABC transporter substrate-binding protein
C3L21_RS28425	COG5001	Diguanylate cyclase
C3L21_RS28425	COG3300	MHYT domain
C3L21_RS28430	COG0673	inositol 2-dehydrogenase activity
C3L21_RS28455	COG4213	ABC transporter substrate-binding protein
C3L21_RS28465	COG4214	carbohydrate transport
C3L21_RS28475	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS28490	COG1305	Transglutaminase-like
C3L21_RS28500	COG2308	Evidence 4 Homologs of previously reported genes of
C3L21_RS28530	COG0513	Belongs to the DEAD box helicase family
C3L21_RS28540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS28540	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C3L21_RS28560	COG3648	Uricase
C3L21_RS28560	COG3195	allantoin biosynthetic process
C3L21_RS28565	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C3L21_RS28570	COG2351	hydroxyisourate hydrolase activity
C3L21_RS28575	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS28580	COG0583	DNA-binding transcription factor activity
C3L21_RS28585	COG4566	intracellular signal transduction
C3L21_RS28590	COG4566	intracellular signal transduction
C3L21_RS28605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3L21_RS28635	COG4372	Transposase
C3L21_RS28665	COG1304	FMN binding
C3L21_RS28675	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS28680	COG1129	ABC transporter
C3L21_RS28685	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS28690	COG1063	alcohol dehydrogenase
C3L21_RS28695	COG1069	ribulokinase activity
C3L21_RS28700	COG2390	Transcriptional regulator
C3L21_RS28710	COG0402	S-adenosylhomocysteine deaminase activity
C3L21_RS28720	COG0583	DNA-binding transcription factor activity
C3L21_RS28730	COG2801	Transposase and inactivated derivatives
C3L21_RS28730	COG3415	Transposase
C3L21_RS28735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS28745	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS28750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3L21_RS28785	COG0024	Methionine aminopeptidase
C3L21_RS28795	COG0477	Major facilitator Superfamily
C3L21_RS28800	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C3L21_RS28820	COG1160	GTP binding
C3L21_RS28825	COG1959	2 iron, 2 sulfur cluster binding
C3L21_RS28855	COG0330	HflC and HflK could
C3L21_RS28870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3L21_RS28870	COG1648	precorrin-2 dehydrogenase activity
C3L21_RS28875	COG0243	molybdopterin cofactor binding
C3L21_RS28885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3L21_RS28900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS28910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS28930	COG0765	amino acid transport
C3L21_RS28940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3L21_RS28945	COG3842	ATPase activity
C3L21_RS28955	COG1175	transmembrane transport
C3L21_RS28960	COG0395	ABC-type sugar transport system, permease component
C3L21_RS28970	COG1609	Transcriptional regulator
C3L21_RS28985	COG0450	alkyl hydroperoxide reductase
C3L21_RS28990	COG0351	phosphomethylpyrimidine kinase
C3L21_RS29000	COG3206	protein involved in exopolysaccharide biosynthesis
C3L21_RS29000	COG0489	protein tyrosine kinase activity
C3L21_RS29005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3L21_RS29010	COG1215	transferase activity, transferring glycosyl groups
C3L21_RS29015	COG1215	transferase activity, transferring glycosyl groups
C3L21_RS29020	COG1215	transferase activity, transferring glycosyl groups
C3L21_RS29025	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS29030	COG2273	Hydrolase Family 16
C3L21_RS29035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3L21_RS29050	COG1525	nuclease
C3L21_RS29060	COG2244	polysaccharide biosynthetic process
C3L21_RS29065	COG0463	Glycosyl transferase, family 2
C3L21_RS29070	COG2327	Polysaccharide pyruvyl transferase
C3L21_RS29075	COG1215	transferase activity, transferring glycosyl groups
C3L21_RS29085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3L21_RS29090	COG1596	polysaccharide export
C3L21_RS29095	COG3307	-O-antigen
C3L21_RS29100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3L21_RS29105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3L21_RS29110	COG5265	(ABC) transporter
C3L21_RS29115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C3L21_RS29120	COG0720	synthase
C3L21_RS29125	COG0602	queuosine metabolic process
C3L21_RS29145	COG0784	Response regulator, receiver
C3L21_RS29150	COG2202	Pas domain
C3L21_RS29150	COG3920	Histidine kinase
C3L21_RS29155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C3L21_RS29155	COG2273	Hydrolase Family 16
C3L21_RS29165	COG1129	ABC transporter
C3L21_RS29170	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS29175	COG3409	Peptidoglycan-binding domain 1 protein
C3L21_RS29175	COG0793	Belongs to the peptidase S41A family
C3L21_RS29190	COG0750	zinc metalloprotease
C3L21_RS29210	COG2182	Extracellular solute-binding protein
C3L21_RS29215	COG1175	transmembrane transport
C3L21_RS29220	COG0395	ABC-type sugar transport system, permease component
C3L21_RS29240	COG1609	Transcriptional regulator
C3L21_RS29245	COG0673	inositol 2-dehydrogenase activity
C3L21_RS29255	COG1653	transport
C3L21_RS29275	COG2186	Transcriptional regulator
C3L21_RS29280	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS29285	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS29290	COG1129	ABC transporter
C3L21_RS29295	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS29300	COG0189	ligase activity
C3L21_RS29330	COG1238	metal cluster binding
C3L21_RS29335	COG0789	Transcriptional regulator
C3L21_RS29340	COG2217	Heavy metal translocating P-type atpase
C3L21_RS29355	COG0640	Transcriptional regulator
C3L21_RS29365	COG0642	Histidine kinase
C3L21_RS29365	COG3850	Histidine kinase
C3L21_RS29385	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3L21_RS29385	COG1902	pentaerythritol trinitrate reductase activity
C3L21_RS29395	COG5425	PFAM Usg family protein
C3L21_RS29400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3L21_RS29405	COG0459	protein refolding
C3L21_RS29430	COG0745	RESPONSE REGULATOR receiver
C3L21_RS29435	COG2205	protein histidine kinase activity
C3L21_RS29445	COG2080	2 iron, 2 sulfur cluster binding
C3L21_RS29450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3L21_RS29455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS29460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3L21_RS29460	COG0475	glutathione-regulated potassium exporter activity
C3L21_RS29485	COG2897	thiosulfate sulfurtransferase activity
C3L21_RS29500	COG3275	phosphorelay sensor kinase activity
C3L21_RS29525	COG3842	ATPase activity
C3L21_RS29530	COG1840	ABC-type Fe3 transport system, periplasmic component
C3L21_RS29540	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS29550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3L21_RS29570	COG1349	DNA-binding transcription factor activity
C3L21_RS29580	COG2855	membrane
C3L21_RS29585	COG0028	Belongs to the TPP enzyme family
C3L21_RS29600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3L21_RS29605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C3L21_RS29610	COG4521	taurine ABC transporter
C3L21_RS29615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS29620	COG2207	Transcriptional regulator
C3L21_RS29625	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C3L21_RS29630	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS29645	COG3485	protocatechuate 3,4-dioxygenase
C3L21_RS29660	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS29665	COG1129	ABC transporter
C3L21_RS29670	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS29675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3L21_RS29680	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
C3L21_RS29685	COG1609	Transcriptional regulator
C3L21_RS29695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3L21_RS29735	COG1295	ribonuclease BN
C3L21_RS29745	COG2323	membrane
C3L21_RS29755	COG0583	DNA-binding transcription factor activity
C3L21_RS29770	COG1295	ribonuclease BN
C3L21_RS29775	COG0673	inositol 2-dehydrogenase activity
C3L21_RS29780	COG1904	glucuronate isomerase
C3L21_RS29785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS29800	COG2186	Transcriptional regulator
C3L21_RS29805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C3L21_RS29810	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS29820	COG1609	Transcriptional regulator
C3L21_RS29825	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS29830	COG1129	ABC transporter
C3L21_RS29835	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS29840	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS29850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS29855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3L21_RS29860	COG2080	2 iron, 2 sulfur cluster binding
C3L21_RS29870	COG0628	permease
C3L21_RS29895	COG3237	CsbD-like
C3L21_RS29910	COG1091	dTDP-4-dehydrorhamnose reductase activity
C3L21_RS29920	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C3L21_RS29960	COG1846	Transcriptional regulator
C3L21_RS29970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS29990	COG0297	glycogen (starch) synthase activity
C3L21_RS30020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3L21_RS30025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C3L21_RS30040	COG2194	sulfuric ester hydrolase activity
C3L21_RS30045	COG0745	RESPONSE REGULATOR receiver
C3L21_RS30050	COG2205	protein histidine kinase activity
C3L21_RS30060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3L21_RS30065	COG1131	(ABC) transporter
C3L21_RS30070	COG0842	Transport permease protein
C3L21_RS30075	COG0842	Transport permease protein
C3L21_RS30090	COG0346	lactoylglutathione lyase activity
C3L21_RS30105	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS30110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS30115	COG0601	transmembrane transport
C3L21_RS30120	COG4166	transmembrane transport
C3L21_RS30135	COG1132	(ABC) transporter
C3L21_RS30145	COG1216	Glycosyl transferase, family 2
C3L21_RS30150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3L21_RS30150	COG2755	lipolytic protein G-D-S-L family
C3L21_RS30160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3L21_RS30165	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS30170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3L21_RS30175	COG0326	Molecular chaperone. Has ATPase activity
C3L21_RS30185	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS30205	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C3L21_RS30215	COG3639	organic phosphonate transmembrane transporter activity
C3L21_RS30220	COG3639	organic phosphonate transmembrane transporter activity
C3L21_RS30230	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C3L21_RS30235	COG3454	Phosphonate metabolism
C3L21_RS30240	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C3L21_RS30245	COG0640	Transcriptional regulator
C3L21_RS30250	COG2814	Major facilitator Superfamily
C3L21_RS30255	COG3344	reverse transcriptase
C3L21_RS30260	COG1228	amidohydrolase
C3L21_RS30265	COG2986	histidine ammonia-lyase
C3L21_RS30275	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C3L21_RS30300	COG1737	Transcriptional regulator
C3L21_RS30305	COG0251	oxidation-reduction process
C3L21_RS30330	COG3842	ATPase activity
C3L21_RS30340	COG0395	ABC-type sugar transport system, permease component
C3L21_RS30350	COG0673	inositol 2-dehydrogenase activity
C3L21_RS30355	COG1174	glycine betaine transport
C3L21_RS30360	COG1125	glycine betaine transport
C3L21_RS30365	COG1174	glycine betaine transport
C3L21_RS30370	COG1732	Glycine betaine
C3L21_RS30375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3L21_RS30395	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS30405	COG1349	DNA-binding transcription factor activity
C3L21_RS30415	COG4953	penicillin-binding protein 1C
C3L21_RS30425	COG0071	Belongs to the small heat shock protein (HSP20) family
C3L21_RS30430	COG0071	Belongs to the small heat shock protein (HSP20) family
C3L21_RS30435	COG0402	S-adenosylhomocysteine deaminase activity
C3L21_RS30455	COG1733	regulation of RNA biosynthetic process
C3L21_RS30465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS30475	COG2351	hydroxyisourate hydrolase activity
C3L21_RS30480	COG3195	allantoin biosynthetic process
C3L21_RS30480	COG3648	Uricase
C3L21_RS30485	COG4266	Belongs to the allantoicase family
C3L21_RS30495	COG2252	PERMEase
C3L21_RS30500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3L21_RS30505	COG1473	amidohydrolase
C3L21_RS30510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C3L21_RS30520	COG3842	ATPase activity
C3L21_RS30525	COG1177	transmembrane transport
C3L21_RS30530	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS30540	COG1609	Transcriptional regulator
C3L21_RS30550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3L21_RS30550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3L21_RS30555	COG1132	(ABC) transporter
C3L21_RS30580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3L21_RS30585	COG0601	transmembrane transport
C3L21_RS30590	COG0747	negative chemotaxis
C3L21_RS30620	COG1234	tRNA 3'-trailer cleavage
C3L21_RS30635	COG0668	transmembrane transport
C3L21_RS30640	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS30650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3L21_RS30660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3L21_RS30665	COG1596	polysaccharide export
C3L21_RS30680	COG0297	glycogen (starch) synthase activity
C3L21_RS30710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3L21_RS30735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS30740	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3L21_RS30750	COG1218	3'(2'),5'-bisphosphate nucleotidase
C3L21_RS30755	COG0529	Catalyzes the synthesis of activated sulfate
C3L21_RS30755	COG2895	sulfate adenylyltransferase (ATP) activity
C3L21_RS30760	COG0175	sulfate reduction
C3L21_RS30765	COG1940	carbohydrate kinase activity
C3L21_RS30765	COG1846	Transcriptional regulator
C3L21_RS30790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3L21_RS30795	COG3842	ATPase activity
C3L21_RS30805	COG0251	oxidation-reduction process
C3L21_RS30815	COG0765	amino acid transport
C3L21_RS30820	COG0765	amino acid transport
C3L21_RS30835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C3L21_RS30845	COG4208	sulfate ABC transporter
C3L21_RS30850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3L21_RS30855	COG0277	FAD linked oxidase domain protein
C3L21_RS30890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3L21_RS30895	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS30905	COG3265	gluconokinase activity
C3L21_RS30910	COG1396	sequence-specific DNA binding
C3L21_RS30920	COG3707	response regulator
C3L21_RS30925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3L21_RS30930	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS30935	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3L21_RS30940	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS30955	COG3254	rhamnose metabolic process
C3L21_RS30960	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS30965	COG3842	ATPase activity
C3L21_RS30970	COG0395	ABC-type sugar transport system, permease component
C3L21_RS31000	COG2079	MmgE PrpD family protein
C3L21_RS31020	COG0165	Argininosuccinate lyase
C3L21_RS31030	COG0456	acetyltransferase
C3L21_RS31045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3L21_RS31070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3L21_RS31075	COG2197	response regulator
C3L21_RS31110	COG1596	polysaccharide export
C3L21_RS31120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3L21_RS31125	COG3206	protein involved in exopolysaccharide biosynthesis
C3L21_RS31125	COG0489	protein tyrosine kinase activity
C3L21_RS31135	COG1442	glycosyl transferase family 8
C3L21_RS31140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3L21_RS31145	COG1216	Glycosyl transferase, family 2
C3L21_RS31160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3L21_RS31170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3L21_RS31175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3L21_RS31200	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS31205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS31235	COG2197	response regulator
C3L21_RS31240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3L21_RS31275	COG1525	nuclease
C3L21_RS31295	COG3285	dna ligase
C3L21_RS31295	COG1793	dna ligase
C3L21_RS31305	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3L21_RS31310	COG2843	Capsule synthesis protein
C3L21_RS31325	COG0601	transmembrane transport
C3L21_RS31330	COG0747	negative chemotaxis
C3L21_RS31430	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS31440	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS31445	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS31445	COG3347	Dehydrogenase
C3L21_RS31455	COG1696	Membrane protein involved in D-alanine export
C3L21_RS31475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3L21_RS31495	COG1609	Transcriptional regulator
C3L21_RS31510	COG1132	(ABC) transporter
C3L21_RS31530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3L21_RS31530	COG0517	IMP dehydrogenase activity
C3L21_RS31540	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C3L21_RS31605	COG2832	Protein of unknown function (DUF454)
C3L21_RS31610	COG4584	PFAM Integrase catalytic
C3L21_RS31615	COG1484	DNA-dependent DNA replication
C3L21_RS31780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3L21_RS31790	COG3415	Transposase
C3L21_RS31805	COG1484	DNA-dependent DNA replication
C3L21_RS31845	COG1609	Transcriptional regulator
C3L21_RS31890	COG3220	belongs to the UPF0276 family
C3L21_RS31910	COG1309	transcriptional regulator
C3L21_RS31915	COG3706	GGDEF domain
C3L21_RS31950	COG3179	chitinase
C3L21_RS31970	COG2201	protein-glutamate methylesterase activity
C3L21_RS31985	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS31990	COG4948	Mandelate Racemase Muconate Lactonizing
C3L21_RS31995	COG2186	Transcriptional regulator
C3L21_RS32005	COG1129	ABC transporter
C3L21_RS32025	COG1129	ABC transporter
C3L21_RS32030	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS32040	COG0667	Aldo Keto reductase
C3L21_RS32045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3L21_RS32055	COG1070	Carbohydrate kinase
C3L21_RS32080	COG0583	DNA-binding transcription factor activity
C3L21_RS32085	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS32090	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS32105	COG0235	Class ii aldolase
C3L21_RS32115	COG1082	Xylose isomerase domain protein TIM barrel
C3L21_RS32125	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS32130	COG1129	ABC transporter
C3L21_RS32150	COG0367	asparagine synthase
C3L21_RS32155	COG2188	Transcriptional regulator
C3L21_RS32170	COG0601	transmembrane transport
C3L21_RS32175	COG0747	negative chemotaxis
C3L21_RS32195	COG2192	nodulation
C3L21_RS32220	COG4585	Histidine kinase
C3L21_RS32225	COG1363	Peptidase, m42
C3L21_RS32275	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS32280	COG1309	transcriptional regulator
C3L21_RS32320	COG5001	Diguanylate cyclase
C3L21_RS32320	COG3300	MHYT domain
C3L21_RS32325	COG1312	Catalyzes the dehydration of D-mannonate
C3L21_RS32330	COG1063	alcohol dehydrogenase
C3L21_RS32335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS32345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS32360	COG3608	succinylglutamate desuccinylase aspartoacylase
C3L21_RS32365	COG0006	proline dipeptidase activity
C3L21_RS32370	COG2423	ornithine cyclodeaminase activity
C3L21_RS32375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3L21_RS32385	COG0765	amino acid transport
C3L21_RS32390	COG0765	amino acid transport
C3L21_RS32400	COG1126	abc transporter atp-binding protein
C3L21_RS32405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS32410	COG1522	sequence-specific DNA binding
C3L21_RS32415	COG1012	belongs to the aldehyde dehydrogenase family
C3L21_RS32420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3L21_RS32425	COG1063	alcohol dehydrogenase
C3L21_RS32430	COG0625	glutathione transferase activity
C3L21_RS32435	COG3842	ATPase activity
C3L21_RS32440	COG0395	ABC-type sugar transport system, permease component
C3L21_RS32445	COG1175	transmembrane transport
C3L21_RS32450	COG1653	transport
C3L21_RS32485	COG4647	ligase activity
C3L21_RS32490	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C3L21_RS32495	COG0145	ligase activity
C3L21_RS32505	COG2010	Cytochrome c
C3L21_RS32505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS32510	COG2080	2 iron, 2 sulfur cluster binding
C3L21_RS32515	COG2010	Cytochrome c
C3L21_RS32515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS32540	COG2080	2 iron, 2 sulfur cluster binding
C3L21_RS32545	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3L21_RS32550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS32560	COG1850	ribulose-bisphosphate carboxylase activity
C3L21_RS32565	COG2186	Transcriptional regulator
C3L21_RS32590	COG0604	alcohol dehydrogenase
C3L21_RS32625	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS32630	COG1177	transmembrane transport
C3L21_RS32635	COG3842	ATPase activity
C3L21_RS32640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3L21_RS32660	COG2186	Transcriptional regulator
C3L21_RS32665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS32675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS32680	COG0698	ribose 5-phosphate isomerase
C3L21_RS32700	COG1309	transcriptional regulator
C3L21_RS32705	COG1609	Transcriptional regulator
C3L21_RS32710	COG1840	ABC-type Fe3 transport system, periplasmic component
C3L21_RS32720	COG3842	ATPase activity
C3L21_RS32755	COG0784	Response regulator, receiver
C3L21_RS32755	COG2205	protein histidine kinase activity
C3L21_RS32770	COG0673	inositol 2-dehydrogenase activity
C3L21_RS32775	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS32780	COG1129	ABC transporter
C3L21_RS32790	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS32795	COG0287	Prephenate dehydrogenase
C3L21_RS32815	COG2207	Transcriptional regulator
C3L21_RS32825	COG2010	Cytochrome c
C3L21_RS32825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS32855	COG1309	transcriptional regulator
C3L21_RS32870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C3L21_RS32895	COG0673	inositol 2-dehydrogenase activity
C3L21_RS32905	COG3842	ATPase activity
C3L21_RS32920	COG1653	transport
C3L21_RS32925	COG1609	Transcriptional regulator
C3L21_RS32945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS32955	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3L21_RS32960	COG1129	ABC transporter
C3L21_RS32965	COG1879	ABC-type sugar transport system periplasmic component
C3L21_RS32975	COG2376	Dihydroxyacetone kinase
C3L21_RS32980	COG1461	Dihydroxyacetone kinase
C3L21_RS32985	COG2376	Dihydroxyacetone kinase
C3L21_RS33010	COG2133	pyrroloquinoline quinone binding
C3L21_RS33020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3L21_RS33025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3L21_RS33030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3L21_RS33040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3L21_RS33065	COG1609	Transcriptional regulator
C3L21_RS33070	COG2233	PERMEase
C3L21_RS33075	COG0402	S-adenosylhomocysteine deaminase activity
C3L21_RS33100	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3L21_RS33105	COG1177	transmembrane transport
C3L21_RS33110	COG3842	ATPase activity
C3L21_RS33115	COG2072	flavoprotein involved in K transport
C3L21_RS33130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3L21_RS33140	COG3246	L-lysine catabolic process to acetate
C3L21_RS33160	COG1765	OsmC-like protein
C3L21_RS33165	COG3938	Belongs to the proline racemase family
C3L21_RS33175	COG3938	Belongs to the proline racemase family
C3L21_RS33180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3L21_RS33190	COG0765	amino acid transport
C3L21_RS33210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C3L21_RS33220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3L21_RS33270	COG1260	myo-inositol-1-phosphate synthase
C3L21_RS33280	COG0673	inositol 2-dehydrogenase activity
C3L21_RS33285	COG1063	alcohol dehydrogenase
C3L21_RS33300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS33325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3L21_RS33345	COG3842	ATPase activity
C3L21_RS33355	COG0395	ABC-type sugar transport system, permease component
C3L21_RS33365	COG2182	Extracellular solute-binding protein
C3L21_RS33370	COG1609	Transcriptional regulator
C3L21_RS33420	COG0596	Alpha beta hydrolase
C3L21_RS33425	COG0745	RESPONSE REGULATOR receiver
C3L21_RS33430	COG2205	protein histidine kinase activity
C3L21_RS33450	COG0300	oxidoreductase activity
C3L21_RS33465	COG0583	DNA-binding transcription factor activity
C3L21_RS33470	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS33480	COG0535	radical SAM domain protein
C3L21_RS33485	COG0535	radical SAM domain protein
C3L21_RS33490	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C3L21_RS33495	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3L21_RS33505	COG0583	DNA-binding transcription factor activity
C3L21_RS33510	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C3L21_RS33515	COG3954	Phosphoribulokinase
C3L21_RS33520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3L21_RS33525	COG0191	fructose-bisphosphate aldolase activity
C3L21_RS33530	COG1850	ribulose-bisphosphate carboxylase activity
C3L21_RS33535	COG4451	ribulose bisphosphate carboxylase, small
C3L21_RS33555	COG3791	Glutathione-dependent formaldehyde-activating
C3L21_RS33560	COG0842	Transport permease protein
C3L21_RS33565	COG1131	(ABC) transporter
C3L21_RS33570	COG1116	anion transmembrane transporter activity
C3L21_RS33630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C3L21_RS33635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C3L21_RS33710	COG3842	ATPase activity
C3L21_RS33715	COG1178	ABC-type Fe3 transport system permease component
C3L21_RS33720	COG1609	Transcriptional regulator
C3L21_RS33745	COG3395	kinase activity
C3L21_RS33750	COG2186	Transcriptional regulator
C3L21_RS33755	COG1454	alcohol dehydrogenase
C3L21_RS33760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C3L21_RS33770	COG0747	negative chemotaxis
C3L21_RS33775	COG0601	transmembrane transport
C3L21_RS33785	COG4172	Belongs to the ABC transporter superfamily
C3L21_RS33790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3L21_RS33810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C3L21_RS33820	COG2233	PERMEase
C3L21_RS33825	COG0523	cobalamin synthesis protein
C3L21_RS33830	COG2080	2 iron, 2 sulfur cluster binding
C3L21_RS33830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3L21_RS33840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3L21_RS33875	COG0583	DNA-binding transcription factor activity
C3L21_RS33915	COG0438	transferase activity, transferring glycosyl groups
C3L21_RS33930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3L21_RS33935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3L21_RS33955	COG0601	transmembrane transport
C3L21_RS33960	COG0747	negative chemotaxis
C3L21_RS33975	COG1802	Transcriptional regulator
C3L21_RS33995	COG0579	oxidoreductase
C3L21_RS34000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3L21_RS34025	COG0028	Belongs to the TPP enzyme family
C3L21_RS34035	COG0392	lysyltransferase activity
C3L21_RS34045	COG3685	Protein conserved in bacteria
C3L21_RS34110	COG2197	response regulator
C3L21_RS34115	COG4585	Histidine kinase
C3L21_RS34120	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS34135	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS34145	COG2814	Major facilitator Superfamily
C3L21_RS34150	COG0659	secondary active sulfate transmembrane transporter activity
C3L21_RS34155	COG1115	amino acid carrier protein
C3L21_RS34160	COG3360	Dodecin
C3L21_RS34190	COG3609	addiction module antidote protein, CC2985 family
C3L21_RS34205	COG3328	transposase activity
C3L21_RS34215	COG1120	ATPase activity
C3L21_RS34220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3L21_RS34245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3L21_RS34250	COG2188	Transcriptional regulator
C3L21_RS34260	COG1192	Involved in chromosome partitioning
C3L21_RS34265	COG1475	DNA binding
C3L21_RS34270	COG0640	Transcriptional regulator
C3L21_RS34305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3L21_RS34340	COG0300	oxidoreductase activity
C3L21_RS34370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3L21_RS34385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3L21_RS34395	COG0210	DNA helicase
C3L21_RS34425	COG4584	PFAM Integrase catalytic
C3L21_RS34430	COG1484	DNA-dependent DNA replication
C3L21_RS34440	COG0183	Belongs to the thiolase family
C3L21_RS34445	COG1024	Enoyl-CoA hydratase
C3L21_RS34445	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3L21_RS34460	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS34465	COG1960	acyl-CoA dehydrogenase activity
C3L21_RS34470	COG1024	Enoyl-CoA hydratase
C3L21_RS34475	COG1028	Short-chain dehydrogenase reductase Sdr
C3L21_RS34535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3L21_RS34540	COG0251	oxidation-reduction process
C3L21_RS34570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3L21_RS34595	COG1280	lysine exporter protein (LysE YggA)
C3L21_RS34600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3L21_RS34605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3L21_RS34620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3L21_RS34640	COG4372	Transposase
C3L21_RS34650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3L21_RS34685	COG3012	SEC-C Motif Domain Protein
C3L21_RS34690	COG4372	Transposase
C3L21_RS34735	COG1475	DNA binding
C3L21_RS34770	COG3344	reverse transcriptase
C3L21_RS34785	COG1192	Involved in chromosome partitioning
C3L21_RS34790	COG1475	DNA binding
C3L21_RS34795	COG0640	Transcriptional regulator
C3L21_RS34835	COG4467	Involved in initiation control of chromosome replication
C3L21_RS34900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3L21_RS34945	COG1063	alcohol dehydrogenase
C3L21_RS34985	COG3344	reverse transcriptase
C3L21_RS34995	COG1414	Transcriptional regulator
C3L21_RS35000	COG3971	2-oxopent-4-enoate hydratase activity
C3L21_RS35005	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C3L21_RS35010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3L21_RS35015	COG0477	Major facilitator Superfamily
C3L21_RS35055	COG3119	arylsulfatase activity
C3L21_RS35095	COG4974	Belongs to the 'phage' integrase family
C3L21_RS35115	COG3415	Transposase
C3L21_RS35125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3L21_RS35140	COG4638	Rieske (2fe-2S)
C3L21_RS35175	COG3328	transposase activity
C3L21_RS35285	COG0745	RESPONSE REGULATOR receiver
C3L21_RS35295	COG3505	Type IV secretory pathway VirD4
C3L21_RS35325	COG3328	transposase activity
C3L21_RS35345	COG3831	ATPase activity
C3L21_RS35350	COG3547	Transposase (IS116 IS110 IS902 family)
C3L21_RS35405	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C3L21_RS35410	COG2948	multi-organism process
C3L21_RS35440	COG0741	lytic transglycosylase activity
C3L21_RS35445	COG3451	type IV secretory pathway VirB4
C3L21_RS35455	COG3838	Conjugal transfer protein Trbc
C3L21_RS35460	COG0741	lytic transglycosylase activity
C3L21_RS35550	COG1278	Cold shock
C3L21_RS35575	COG1484	DNA-dependent DNA replication
C3L21_RS35580	COG4584	PFAM Integrase catalytic
C3L21_RS35645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3L21_RS35645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3L21_RS35650	COG1999	signal sequence binding
C3L21_RS35660	COG2132	Multicopper oxidase
C3L21_RS35675	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3L21_RS35740	COG0789	Transcriptional regulator
C3L21_RS35745	COG1309	transcriptional regulator
C3L21_RS35780	COG1238	metal cluster binding
C3L21_RS35825	COG1376	ErfK ybiS ycfS ynhG family protein
C3L21_RS35835	COG1475	DNA binding
C3L21_RS35860	COG2184	nucleotidyltransferase activity
C3L21_RS35865	COG4227	nucleotidyltransferase activity