locus-tag	class	description
SMB554_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SMB554_RS00010	COG0424	maF-like protein
SMB554_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMB554_RS00020	COG0237	dephospho-CoA kinase activity
SMB554_RS00025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMB554_RS00030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SMB554_RS00080	COG1802	Transcriptional regulator
SMB554_RS00085	COG2721	sulfolactate sulfo-lyase activity
SMB554_RS00105	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS00110	COG1063	alcohol dehydrogenase
SMB554_RS00130	COG0135	phosphoribosylanthranilate isomerase activity
SMB554_RS00135	COG0133	tryptophan synthase activity
SMB554_RS00140	COG0159	tryptophan synthase activity
SMB554_RS00145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMB554_RS00155	COG3385	transposase activity
SMB554_RS00165	COG1074	ATP-dependent DNA helicase activity
SMB554_RS00170	COG2887	Belongs to the helicase family. UvrD subfamily
SMB554_RS00175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMB554_RS00180	COG3178	'Phosphotransferase
SMB554_RS00185	COG2205	protein histidine kinase activity
SMB554_RS00190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMB554_RS00200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMB554_RS00200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMB554_RS00215	COG2205	protein histidine kinase activity
SMB554_RS00220	COG0745	RESPONSE REGULATOR receiver
SMB554_RS00225	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMB554_RS00235	COG1652	LysM domain
SMB554_RS00245	COG1072	(Pantothenic acid kinase))
SMB554_RS00250	COG0140	phosphoribosyl-ATP diphosphatase activity
SMB554_RS00255	COG0107	imidazoleglycerol-phosphate synthase activity
SMB554_RS00260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMB554_RS00265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMB554_RS00275	COG0131	Imidazoleglycerol-phosphate dehydratase
SMB554_RS00280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMB554_RS00290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SMB554_RS00300	COG2124	cytochrome p450
SMB554_RS00310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMB554_RS00325	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SMB554_RS00335	COG1643	Atp-dependent helicase
SMB554_RS00340	COG4136	ATPase activity
SMB554_RS00345	COG4135	transport system, permease component
SMB554_RS00350	COG4134	Bacterial extracellular solute-binding protein
SMB554_RS00410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMB554_RS00415	COG0626	cystathionine gamma-synthase activity
SMB554_RS00440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMB554_RS00450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMB554_RS00450	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMB554_RS00455	COG4311	Sarcosine oxidase, delta subunit
SMB554_RS00460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS00465	COG4977	sequence-specific DNA binding
SMB554_RS00470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMB554_RS00475	COG2218	PFAM glutamate synthase alpha subunit domain protein
SMB554_RS00480	COG0069	glutamate synthase activity
SMB554_RS00485	COG0174	glutamine synthetase
SMB554_RS00500	COG0531	amino acid
SMB554_RS00530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMB554_RS00555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMB554_RS00565	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMB554_RS00570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS00580	COG2186	Transcriptional regulator
SMB554_RS00595	COG3842	ATPase activity
SMB554_RS00605	COG0673	inositol 2-dehydrogenase activity
SMB554_RS00610	COG0395	ABC-type sugar transport system, permease component
SMB554_RS00615	COG1175	transmembrane transport
SMB554_RS00620	COG1653	transport
SMB554_RS00625	COG1309	transcriptional regulator
SMB554_RS00630	COG0673	inositol 2-dehydrogenase activity
SMB554_RS00650	COG0673	inositol 2-dehydrogenase activity
SMB554_RS00675	COG3845	ABC transporter
SMB554_RS00680	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS00685	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS00700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SMB554_RS00705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMB554_RS00710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMB554_RS00715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMB554_RS00750	COG4964	Belongs to the GSP D family
SMB554_RS00780	COG3385	transposase activity
SMB554_RS00790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMB554_RS00800	COG0791	NLP P60 protein
SMB554_RS00810	COG4172	Belongs to the ABC transporter superfamily
SMB554_RS00815	COG4239	(ABC) transporter, permease
SMB554_RS00820	COG4174	ABC transporter (Permease)
SMB554_RS00825	COG4166	transmembrane transport
SMB554_RS00830	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
SMB554_RS00835	COG1803	Methylglyoxal synthase
SMB554_RS00840	COG0837	glucose binding
SMB554_RS00845	COG1132	(ABC) transporter
SMB554_RS00850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMB554_RS00855	COG0588	phosphoglycerate mutase activity
SMB554_RS00860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMB554_RS00885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMB554_RS00905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMB554_RS00905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMB554_RS00915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMB554_RS00935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMB554_RS00940	COG0443	Heat shock 70 kDa protein
SMB554_RS00945	COG0484	heat shock protein binding
SMB554_RS00960	COG0306	phosphate transporter
SMB554_RS00965	COG1392	Phosphate transport regulator
SMB554_RS00970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMB554_RS00990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMB554_RS00995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS01005	COG0673	inositol 2-dehydrogenase activity
SMB554_RS01010	COG0395	ABC-type sugar transport system, permease component
SMB554_RS01015	COG1175	transmembrane transport
SMB554_RS01025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SMB554_RS01030	COG2971	BadF BadG BcrA BcrD
SMB554_RS01035	COG2188	Transcriptional regulator
SMB554_RS01040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMB554_RS01045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMB554_RS01055	COG3142	Participates in the control of copper homeostasis
SMB554_RS01060	COG1940	carbohydrate kinase activity
SMB554_RS01075	COG2900	Belongs to the SlyX family
SMB554_RS01080	COG1744	ABC transporter substrate-binding protein PnrA-like
SMB554_RS01085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMB554_RS01110	COG1917	Cupin 2, conserved barrel domain protein
SMB554_RS01110	COG2207	Transcriptional regulator
SMB554_RS01115	COG2814	Major facilitator Superfamily
SMB554_RS01120	COG4771	TonB-dependent receptor
SMB554_RS01130	COG2814	Major facilitator Superfamily
SMB554_RS01150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMB554_RS01155	COG3474	cytochrome
SMB554_RS01160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMB554_RS01165	COG1605	Chorismate mutase
SMB554_RS01165	COG0077	Prephenate dehydratase
SMB554_RS01180	COG2378	regulation of single-species biofilm formation
SMB554_RS01185	COG2816	NAD+ diphosphatase activity
SMB554_RS01200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMB554_RS01205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMB554_RS01215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMB554_RS01220	COG2951	lytic endotransglycosylase activity
SMB554_RS01225	COG2814	Major facilitator Superfamily
SMB554_RS01230	COG0779	Required for maturation of 30S ribosomal subunits
SMB554_RS01235	COG0195	Participates in both transcription termination and antitermination
SMB554_RS01235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMB554_RS01245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMB554_RS01250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMB554_RS01255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMB554_RS01265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMB554_RS01270	COG1185	polyribonucleotide nucleotidyltransferase activity
SMB554_RS01280	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMB554_RS01290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMB554_RS01300	COG2860	membrane
SMB554_RS01320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMB554_RS01325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMB554_RS01330	COG0539	negative regulation of cytoplasmic translation
SMB554_RS01360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS01365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMB554_RS01380	COG2801	Transposase and inactivated derivatives
SMB554_RS01380	COG3415	Transposase
SMB554_RS01415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMB554_RS01425	COG0481	GTPase activity
SMB554_RS01445	COG3932	Exopolysaccharide synthesis, ExoD
SMB554_RS01450	COG2885	chlorophyll binding
SMB554_RS01455	COG1509	lysine 2,3-aminomutase activity
SMB554_RS01460	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SMB554_RS01465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMB554_RS01470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMB554_RS01490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMB554_RS01495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMB554_RS01500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMB554_RS01505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMB554_RS01510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMB554_RS01510	COG0072	phenylalanine-tRNA ligase activity
SMB554_RS01520	COG0667	Aldo Keto reductase
SMB554_RS01545	COG0667	Aldo Keto reductase
SMB554_RS01565	COG1570	exodeoxyribonuclease VII activity
SMB554_RS01570	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMB554_RS01575	COG1846	Transcriptional regulator
SMB554_RS01580	COG0697	spore germination
SMB554_RS01585	COG2309	aminopeptidase activity
SMB554_RS01590	COG0625	glutathione transferase activity
SMB554_RS01605	COG1393	Belongs to the ArsC family
SMB554_RS01615	COG1448	Aminotransferase
SMB554_RS01650	COG0519	Catalyzes the synthesis of GMP from XMP
SMB554_RS01650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMB554_RS01665	COG1247	-acetyltransferase
SMB554_RS01700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMB554_RS01710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMB554_RS01720	COG1968	undecaprenyl-diphosphatase activity
SMB554_RS01730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS01740	COG0284	orotidine-5'-phosphate decarboxylase activity
SMB554_RS01750	COG3963	phosphatidate phosphatase activity
SMB554_RS01760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMB554_RS01765	COG0792	nuclease activity
SMB554_RS01770	COG0189	ligase activity
SMB554_RS01780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMB554_RS01795	COG0697	spore germination
SMB554_RS01800	COG1522	sequence-specific DNA binding
SMB554_RS01805	COG0756	dUTP diphosphatase activity
SMB554_RS01810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMB554_RS01825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS01835	COG3718	enzyme involved in inositol metabolism
SMB554_RS01840	COG1082	Xylose isomerase domain protein TIM barrel
SMB554_RS01875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMB554_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS01905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMB554_RS01910	COG2226	methyltransferase
SMB554_RS01915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMB554_RS01920	COG1024	Enoyl-CoA hydratase
SMB554_RS01925	COG0268	Binds directly to 16S ribosomal RNA
SMB554_RS01935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMB554_RS01940	COG3795	YCII-related domain
SMB554_RS01945	COG4941	Belongs to the sigma-70 factor family
SMB554_RS01960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMB554_RS01965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMB554_RS01975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMB554_RS01980	COG1420	regulation of RNA biosynthetic process
SMB554_RS01985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMB554_RS01995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMB554_RS02000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMB554_RS02005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMB554_RS02010	COG1137	ATPase activity
SMB554_RS02015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SMB554_RS02025	COG0616	signal peptide processing
SMB554_RS02030	COG0776	regulation of translation
SMB554_RS02045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMB554_RS02045	COG0116	Belongs to the methyltransferase superfamily
SMB554_RS02050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMB554_RS02055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMB554_RS02060	COG2205	protein histidine kinase activity
SMB554_RS02060	COG5002	protein histidine kinase activity
SMB554_RS02060	COG0784	Response regulator, receiver
SMB554_RS02070	COG0281	malic enzyme
SMB554_RS02070	COG0280	phosphate acetyltransferase
SMB554_RS02075	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMB554_RS02080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMB554_RS02085	COG0728	peptidoglycan biosynthetic process
SMB554_RS02095	COG0180	Tryptophanyl-tRNA synthetase
SMB554_RS02105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SMB554_RS02125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMB554_RS02130	COG1702	phosphate starvation-inducible protein PhoH
SMB554_RS02135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMB554_RS02140	COG4535	Mg2 and Co2 transporter CorC
SMB554_RS02145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMB554_RS02150	COG1396	sequence-specific DNA binding
SMB554_RS02155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMB554_RS02160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMB554_RS02165	COG3328	transposase activity
SMB554_RS02175	COG0071	Belongs to the small heat shock protein (HSP20) family
SMB554_RS02180	COG1957	nucleoside hydrolase
SMB554_RS02185	COG0840	transmembrane signaling receptor activity
SMB554_RS02190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMB554_RS02200	COG0242	peptide deformylase activity
SMB554_RS02205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMB554_RS02210	COG0101	tRNA pseudouridine synthase activity
SMB554_RS02225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMB554_RS02240	COG0657	acetylesterase activity
SMB554_RS02245	COG0583	DNA-binding transcription factor activity
SMB554_RS02255	COG0513	Belongs to the DEAD box helicase family
SMB554_RS02265	COG2171	N-acyltransferase activity
SMB554_RS02285	COG2169	Transcriptional regulator
SMB554_RS02285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMB554_RS02320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMB554_RS02330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMB554_RS02340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMB554_RS02350	COG0706	membrane insertase activity
SMB554_RS02355	COG0594	ribonuclease P activity
SMB554_RS02360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMB554_RS02380	COG5002	protein histidine kinase activity
SMB554_RS02410	COG1304	FMN binding
SMB554_RS02435	COG3328	transposase activity
SMB554_RS02475	COG0667	Aldo Keto reductase
SMB554_RS02515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS02525	COG2259	Doxx family
SMB554_RS02555	COG1072	(Pantothenic acid kinase))
SMB554_RS02560	COG0418	dihydroorotase activity
SMB554_RS02565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMB554_RS02575	COG0166	Belongs to the GPI family
SMB554_RS02580	COG0318	PFAM AMP-dependent synthetase and ligase
SMB554_RS02585	COG2814	Major facilitator Superfamily
SMB554_RS02590	COG0628	permease
SMB554_RS02605	COG4589	Belongs to the CDS family
SMB554_RS02630	COG2326	polyphosphate kinase activity
SMB554_RS02635	COG5002	protein histidine kinase activity
SMB554_RS02645	COG0573	inorganic phosphate transmembrane transporter activity
SMB554_RS02655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMB554_RS02660	COG0704	Plays a role in the regulation of phosphate uptake
SMB554_RS02665	COG0745	RESPONSE REGULATOR receiver
SMB554_RS02675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMB554_RS02680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMB554_RS02690	COG2967	ApaG domain
SMB554_RS02695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMB554_RS02705	COG0717	Belongs to the dCTP deaminase family
SMB554_RS02715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS02735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMB554_RS02740	COG0387	Pfam Sodium calcium exchanger
SMB554_RS02755	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMB554_RS02755	COG1024	Enoyl-CoA hydratase
SMB554_RS02760	COG0183	Belongs to the thiolase family
SMB554_RS02765	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS02775	COG0730	response to heat
SMB554_RS02800	COG1201	RNA secondary structure unwinding
SMB554_RS02805	COG1959	2 iron, 2 sulfur cluster binding
SMB554_RS02810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMB554_RS02835	COG0534	Mate efflux family protein
SMB554_RS02840	COG0167	dihydroorotate dehydrogenase activity
SMB554_RS02865	COG1970	mechanosensitive ion channel activity
SMB554_RS02870	COG0436	Aminotransferase
SMB554_RS02885	COG1294	oxidase, subunit
SMB554_RS02890	COG1271	oxidase subunit
SMB554_RS02895	COG1473	amidohydrolase
SMB554_RS02905	COG4215	(ABC) transporter
SMB554_RS02910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS02920	COG1309	transcriptional regulator
SMB554_RS02950	COG1959	2 iron, 2 sulfur cluster binding
SMB554_RS02955	COG0517	IMP dehydrogenase activity
SMB554_RS02955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMB554_RS02965	COG1368	sulfuric ester hydrolase activity
SMB554_RS02970	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS02975	COG0156	8-amino-7-oxononanoate synthase activity
SMB554_RS02990	COG1335	isochorismatase
SMB554_RS02995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMB554_RS03025	COG2132	Multicopper oxidase
SMB554_RS03055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMB554_RS03065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMB554_RS03070	COG5328	Belongs to the UPF0262 family
SMB554_RS03080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMB554_RS03085	COG0424	maF-like protein
SMB554_RS03090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SMB554_RS03140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMB554_RS03155	COG4952	isomerase
SMB554_RS03160	COG3347	Dehydrogenase
SMB554_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS03165	COG1349	DNA-binding transcription factor activity
SMB554_RS03175	COG1129	ABC transporter
SMB554_RS03180	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS03190	COG3254	rhamnose metabolic process
SMB554_RS03200	COG0840	transmembrane signaling receptor activity
SMB554_RS03210	COG0745	RESPONSE REGULATOR receiver
SMB554_RS03215	COG0643	Histidine kinase
SMB554_RS03215	COG2198	Histidine kinase
SMB554_RS03220	COG0835	chemotaxis
SMB554_RS03225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMB554_RS03230	COG2201	protein-glutamate methylesterase activity
SMB554_RS03235	COG0745	RESPONSE REGULATOR receiver
SMB554_RS03240	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMB554_RS03255	COG1766	The M ring may be actively involved in energy transduction
SMB554_RS03260	COG2771	luxR family
SMB554_RS03275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMB554_RS03280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMB554_RS03285	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMB554_RS03290	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMB554_RS03295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMB554_RS03305	COG4786	Flagellar basal body rod
SMB554_RS03310	COG1157	protein secretion by the type III secretion system
SMB554_RS03320	COG1815	bacterial-type flagellum-dependent cell motility
SMB554_RS03325	COG1558	bacterial-type flagellum-dependent cell motility
SMB554_RS03330	COG1677	Flagellar hook-basal body complex protein FliE
SMB554_RS03335	COG4786	Flagellar basal body rod
SMB554_RS03340	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
SMB554_RS03345	COG1706	bacterial-type flagellum-dependent cell motility
SMB554_RS03355	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SMB554_RS03365	COG1338	Plays a role in the flagellum-specific transport system
SMB554_RS03370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMB554_RS03375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMB554_RS03380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMB554_RS03385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMB554_RS03395	COG1360	Flagellar Motor Protein
SMB554_RS03420	COG1749	Flagellar hook protein flgE
SMB554_RS03440	COG5443	negative regulation of bacterial-type flagellum assembly
SMB554_RS03445	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SMB554_RS03450	COG4794	Type iii secretion
SMB554_RS03455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMB554_RS03490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMB554_RS03495	COG1609	Transcriptional regulator
SMB554_RS03500	COG1653	transport
SMB554_RS03505	COG1175	transmembrane transport
SMB554_RS03510	COG0395	ABC-type sugar transport system, permease component
SMB554_RS03515	COG0366	Alpha amylase catalytic
SMB554_RS03520	COG3842	ATPase activity
SMB554_RS03530	COG3385	transposase activity
SMB554_RS03540	COG0129	dihydroxy-acid dehydratase activity
SMB554_RS03545	COG0363	glucosamine-6-phosphate deaminase activity
SMB554_RS03550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SMB554_RS03555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS03565	COG2081	HI0933 family
SMB554_RS03575	COG2972	Histidine kinase
SMB554_RS03575	COG0840	transmembrane signaling receptor activity
SMB554_RS03595	COG2224	Isocitrate lyase
SMB554_RS03600	COG1396	sequence-specific DNA binding
SMB554_RS03600	COG3800	Transcriptional regulator
SMB554_RS03610	COG3842	ATPase activity
SMB554_RS03615	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMB554_RS03620	COG1177	transmembrane transport
SMB554_RS03630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMB554_RS03635	COG1178	ABC-type Fe3 transport system permease component
SMB554_RS03640	COG2205	protein histidine kinase activity
SMB554_RS03675	COG4269	membrane
SMB554_RS03685	COG1840	ABC-type Fe3 transport system, periplasmic component
SMB554_RS03690	COG1959	2 iron, 2 sulfur cluster binding
SMB554_RS03695	COG0747	negative chemotaxis
SMB554_RS03700	COG0601	transmembrane transport
SMB554_RS03705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS03710	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS03715	COG4608	Belongs to the ABC transporter superfamily
SMB554_RS03720	COG0251	oxidation-reduction process
SMB554_RS03735	COG0784	Response regulator, receiver
SMB554_RS03760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS03770	COG1285	pathogenesis
SMB554_RS03825	COG2059	Chromate
SMB554_RS03850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SMB554_RS03860	COG0477	Major facilitator Superfamily
SMB554_RS03880	COG0412	Dienelactone hydrolase
SMB554_RS03885	COG0583	DNA-binding transcription factor activity
SMB554_RS03890	COG0753	catalase activity
SMB554_RS03895	COG0583	DNA-binding transcription factor activity
SMB554_RS03930	COG0306	phosphate transporter
SMB554_RS03940	COG1725	Transcriptional regulator
SMB554_RS03950	COG0583	DNA-binding transcription factor activity
SMB554_RS03955	COG0277	FAD linked oxidase domain protein
SMB554_RS03960	COG0277	FAD linked oxidase domain protein
SMB554_RS03965	COG0247	lactate metabolic process
SMB554_RS03970	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS03970	COG1388	LysM domain
SMB554_RS03975	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS03980	COG2818	Glycosylase
SMB554_RS03985	COG1953	Uracil, thiamine, allantoin
SMB554_RS04000	COG0124	histidyl-tRNA synthetase
SMB554_RS04005	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMB554_RS04010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMB554_RS04015	COG0625	glutathione transferase activity
SMB554_RS04030	COG0459	protein refolding
SMB554_RS04035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMB554_RS04050	COG0196	riboflavin kinase activity
SMB554_RS04055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMB554_RS04070	COG0590	tRNA wobble adenosine to inosine editing
SMB554_RS04075	COG1187	pseudouridine synthase activity
SMB554_RS04080	COG0742	ribosomal rna small subunit methyltransferase
SMB554_RS04085	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMB554_RS04090	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
SMB554_RS04100	COG0475	glutathione-regulated potassium exporter activity
SMB554_RS04100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMB554_RS04105	COG0312	modulator of DNA gyrase
SMB554_RS04110	COG0483	inositol monophosphate 1-phosphatase activity
SMB554_RS04120	COG1519	Transferase
SMB554_RS04130	COG1663	tetraacyldisaccharide 4'-kinase activity
SMB554_RS04145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMB554_RS04155	COG3300	MHYT domain
SMB554_RS04155	COG5001	Diguanylate cyclase
SMB554_RS04160	COG0583	DNA-binding transcription factor activity
SMB554_RS04165	COG5598	trimethylamine methyltransferase
SMB554_RS04180	COG0129	dihydroxy-acid dehydratase activity
SMB554_RS04185	COG3386	PFAM SMP-30 Gluconolaconase
SMB554_RS04190	COG0800	Aldolase
SMB554_RS04195	COG3734	2-keto-3-deoxy-galactonokinase
SMB554_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS04205	COG1414	Transcriptional regulator
SMB554_RS04215	COG2771	luxR family
SMB554_RS04220	COG0489	protein tyrosine kinase activity
SMB554_RS04225	COG0598	Magnesium transport protein CorA
SMB554_RS04230	COG3158	transport of potassium into the cell
SMB554_RS04245	COG0356	it plays a direct role in the translocation of protons across the membrane
SMB554_RS04250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMB554_RS04255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMB554_RS04260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMB554_RS04265	COG3328	transposase activity
SMB554_RS04275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMB554_RS04295	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMB554_RS04300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMB554_RS04310	COG0142	geranyltranstransferase activity
SMB554_RS04335	COG0752	glycyl-tRNA synthetase alpha subunit
SMB554_RS04345	COG1704	LemA family
SMB554_RS04355	COG0751	glycine-tRNA ligase activity
SMB554_RS04360	COG1683	Conserved Protein
SMB554_RS04370	COG0151	Belongs to the GarS family
SMB554_RS04375	COG5001	Diguanylate cyclase
SMB554_RS04385	COG2223	nitrite transmembrane transporter activity
SMB554_RS04390	COG4977	sequence-specific DNA binding
SMB554_RS04395	COG3713	MltA-interacting MipA family protein
SMB554_RS04400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMB554_RS04420	COG0009	L-threonylcarbamoyladenylate synthase
SMB554_RS04430	COG4638	Rieske (2fe-2S)
SMB554_RS04435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMB554_RS04460	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS04480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMB554_RS04490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMB554_RS04495	COG1741	Belongs to the pirin family
SMB554_RS04500	COG1722	exodeoxyribonuclease VII activity
SMB554_RS04505	COG0123	including yeast histone deacetylase and acetoin utilization protein
SMB554_RS04510	COG1063	alcohol dehydrogenase
SMB554_RS04520	COG0183	Belongs to the thiolase family
SMB554_RS04525	COG0318	PFAM AMP-dependent synthetase and ligase
SMB554_RS04530	COG1268	BioY protein
SMB554_RS04535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SMB554_RS04540	COG1122	ATPase activity
SMB554_RS04545	COG3214	Protein conserved in bacteria
SMB554_RS04550	COG0312	modulator of DNA gyrase
SMB554_RS04565	COG0259	pyridoxamine-phosphate oxidase activity
SMB554_RS04575	COG0484	heat shock protein binding
SMB554_RS04580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMB554_RS04595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMB554_RS04600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMB554_RS04600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMB554_RS04615	COG1565	acr, cog1565
SMB554_RS04615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMB554_RS04620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMB554_RS04625	COG0109	protoheme IX farnesyltransferase activity
SMB554_RS04635	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SMB554_RS04655	COG3346	SURF1 family
SMB554_RS04660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMB554_RS04665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SMB554_RS04670	COG0328	RNA-DNA hybrid ribonuclease activity
SMB554_RS04675	COG0678	peroxiredoxin activity
SMB554_RS04675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMB554_RS04685	COG1678	Uncharacterized ACR, COG1678
SMB554_RS04690	COG5001	Diguanylate cyclase
SMB554_RS04695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMB554_RS04700	COG0612	Peptidase, M16
SMB554_RS04720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMB554_RS04730	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SMB554_RS04740	COG1194	a g-specific adenine glycosylase
SMB554_RS04760	COG1196	nuclear chromosome segregation
SMB554_RS04765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMB554_RS04765	COG0574	Belongs to the PEP-utilizing enzyme family
SMB554_RS04800	COG3264	Mechanosensitive ion channel
SMB554_RS04800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMB554_RS04825	COG2895	sulfate adenylyltransferase (ATP) activity
SMB554_RS04830	COG0175	sulfate reduction
SMB554_RS04835	COG0175	sulfate reduction
SMB554_RS04850	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMB554_RS04860	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS04865	COG3119	arylsulfatase activity
SMB554_RS04870	COG1309	transcriptional regulator
SMB554_RS04880	COG5001	Diguanylate cyclase
SMB554_RS04880	COG3300	MHYT domain
SMB554_RS04910	COG0583	DNA-binding transcription factor activity
SMB554_RS04925	COG1388	LysM domain
SMB554_RS04925	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS04930	COG1846	Transcriptional regulator
SMB554_RS04935	COG1764	response to oxidative stress
SMB554_RS04940	COG2824	Alkylphosphonate utilization operon protein PhnA
SMB554_RS04945	COG0433	COG0433 Predicted ATPase
SMB554_RS04955	COG0656	L-ascorbic acid biosynthetic process
SMB554_RS04965	COG4106	trans-aconitate 2-methyltransferase activity
SMB554_RS05000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMB554_RS05020	COG2010	Cytochrome c
SMB554_RS05030	COG0789	Transcriptional regulator
SMB554_RS05040	COG4993	Dehydrogenase
SMB554_RS05045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SMB554_RS05060	COG2514	catechol 2,3-dioxygenase activity
SMB554_RS05075	COG1272	protein, Hemolysin III
SMB554_RS05085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMB554_RS05090	COG2111	Na H antiporter
SMB554_RS05090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMB554_RS05095	COG2111	Na H antiporter
SMB554_RS05100	COG1006	Multisubunit Na H antiporter MnhC subunit
SMB554_RS05105	COG0651	ATP synthesis coupled electron transport
SMB554_RS05110	COG1863	multisubunit Na H antiporter MnhE subunit
SMB554_RS05115	COG2212	antiporter activity
SMB554_RS05120	COG1320	monovalent cation:proton antiporter activity
SMB554_RS05125	COG4957	zinc ion binding
SMB554_RS05130	COG2166	iron-sulfur cluster assembly
SMB554_RS05140	COG2205	protein histidine kinase activity
SMB554_RS05190	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMB554_RS05195	COG2983	Belongs to the UPF0260 family
SMB554_RS05250	COG4235	cytochrome complex assembly
SMB554_RS05255	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SMB554_RS05260	COG1138	Cytochrome C-type biogenesis protein
SMB554_RS05265	COG3088	subunit of a heme lyase
SMB554_RS05270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMB554_RS05275	COG0745	RESPONSE REGULATOR receiver
SMB554_RS05280	COG2205	protein histidine kinase activity
SMB554_RS05285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMB554_RS05290	COG2202	Pas domain
SMB554_RS05290	COG2205	protein histidine kinase activity
SMB554_RS05295	COG0308	aminopeptidase N
SMB554_RS05305	COG2814	Major facilitator Superfamily
SMB554_RS05320	COG1573	uracil-dna glycosylase
SMB554_RS05325	COG0443	Heat shock 70 kDa protein
SMB554_RS05345	COG4176	ABC-type proline glycine betaine transport system permease component
SMB554_RS05355	COG1733	regulation of RNA biosynthetic process
SMB554_RS05365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SMB554_RS05370	COG0463	Glycosyl transferase, family 2
SMB554_RS05380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMB554_RS05385	COG1742	UPF0060 membrane protein
SMB554_RS05400	COG0625	glutathione transferase activity
SMB554_RS05415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMB554_RS05430	COG3093	addiction module antidote protein HigA
SMB554_RS05435	COG3549	Plasmid maintenance system killer
SMB554_RS05445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SMB554_RS05450	COG4974	Belongs to the 'phage' integrase family
SMB554_RS05455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SMB554_RS05465	COG0741	lytic transglycosylase activity
SMB554_RS05470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMB554_RS05475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMB554_RS05495	COG1758	RNA polymerase activity
SMB554_RS05525	COG0736	holo-[acyl-carrier-protein] synthase activity
SMB554_RS05530	COG0681	Belongs to the peptidase S26 family
SMB554_RS05535	COG0571	ribonuclease III activity
SMB554_RS05540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMB554_RS05545	COG0431	NADPH-dependent FMN reductase
SMB554_RS05565	COG0584	glycerophosphoryl diester phosphodiesterase
SMB554_RS05570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMB554_RS05575	COG2183	response to ionizing radiation
SMB554_RS05585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SMB554_RS05590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS05610	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS05615	COG1381	Involved in DNA repair and RecF pathway recombination
SMB554_RS05630	COG1418	mRNA catabolic process
SMB554_RS05645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SMB554_RS05650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMB554_RS05660	COG2032	superoxide dismutase activity
SMB554_RS05665	COG2274	protein secretion by the type I secretion system
SMB554_RS05690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SMB554_RS05715	COG1051	belongs to the nudix hydrolase family
SMB554_RS05735	COG0215	cysteine-tRNA ligase activity
SMB554_RS05760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMB554_RS05765	COG2962	Rard protein
SMB554_RS05780	COG5265	(ABC) transporter
SMB554_RS05785	COG0688	phosphatidylethanolamine metabolic process
SMB554_RS05790	COG1183	phosphatidylcholine synthase activity
SMB554_RS05795	COG3385	transposase activity
SMB554_RS05800	COG4221	oxidoreductase activity
SMB554_RS05805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMB554_RS05820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMB554_RS05840	COG0305	Participates in initiation and elongation during chromosome replication
SMB554_RS05860	COG0359	binds to the 23S rRNA
SMB554_RS05870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMB554_RS05875	COG0360	Binds together with S18 to 16S ribosomal RNA
SMB554_RS05885	COG0667	Aldo Keto reductase
SMB554_RS05890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMB554_RS05900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMB554_RS05905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMB554_RS05910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMB554_RS05915	COG1561	YicC-like family, N-terminal region
SMB554_RS05920	COG0194	GDP metabolic process
SMB554_RS05930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMB554_RS05935	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMB554_RS05965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMB554_RS05990	COG0488	(ABC) transporter
SMB554_RS06000	COG0318	PFAM AMP-dependent synthetase and ligase
SMB554_RS06015	COG0105	UTP biosynthetic process
SMB554_RS06040	COG0314	molybdopterin synthase activity
SMB554_RS06055	COG0322	excinuclease ABC activity
SMB554_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS06085	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SMB554_RS06090	COG0243	molybdopterin cofactor binding
SMB554_RS06095	COG0494	nUDIX hydrolase
SMB554_RS06110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMB554_RS06115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMB554_RS06120	COG0628	permease
SMB554_RS06130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMB554_RS06135	COG0248	Ppx GppA phosphatase
SMB554_RS06145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS06150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SMB554_RS06155	COG2132	Multicopper oxidase
SMB554_RS06170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMB554_RS06180	COG0459	protein refolding
SMB554_RS06195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMB554_RS06210	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SMB554_RS06220	COG0113	porphobilinogen synthase activity
SMB554_RS06235	COG2989	Protein conserved in bacteria
SMB554_RS06240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMB554_RS06245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMB554_RS06250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMB554_RS06250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMB554_RS06265	COG0519	Catalyzes the synthesis of GMP from XMP
SMB554_RS06275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMB554_RS06280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMB554_RS06285	COG2814	Major facilitator Superfamily
SMB554_RS06290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMB554_RS06310	COG0416	fatty acid biosynthetic process
SMB554_RS06315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMB554_RS06320	COG0776	regulation of translation
SMB554_RS06355	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS06370	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS06390	COG0110	maltose O-acetyltransferase activity
SMB554_RS06405	COG1612	heme a metabolic process
SMB554_RS06410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMB554_RS06415	COG0010	Belongs to the arginase family
SMB554_RS06420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMB554_RS06425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMB554_RS06435	COG1024	Enoyl-CoA hydratase
SMB554_RS06445	COG1832	CoA-binding protein
SMB554_RS06460	COG2124	cytochrome p450
SMB554_RS06470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMB554_RS06475	COG0740	serine-type endopeptidase activity
SMB554_RS06480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMB554_RS06485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMB554_RS06490	COG0776	regulation of translation
SMB554_RS06510	COG0420	3'-5' exonuclease activity
SMB554_RS06515	COG4717	serine-type aminopeptidase activity
SMB554_RS06545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMB554_RS06550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMB554_RS06555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMB554_RS06560	COG0649	NAD binding
SMB554_RS06570	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SMB554_RS06575	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SMB554_RS06580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMB554_RS06580	COG3743	rRNA binding
SMB554_RS06590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMB554_RS06595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMB554_RS06605	COG0713	ATP synthesis coupled electron transport
SMB554_RS06620	COG1007	ATP synthesis coupled electron transport
SMB554_RS06635	COG0346	lactoylglutathione lyase activity
SMB554_RS06660	COG0442	prolyl-tRNA aminoacylation
SMB554_RS06670	COG1136	(ABC) transporter
SMB554_RS06685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMB554_RS06695	COG0784	Response regulator, receiver
SMB554_RS06705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMB554_RS06725	COG0557	exoribonuclease II activity
SMB554_RS06730	COG1754	DNA topoisomerase type I activity
SMB554_RS06730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMB554_RS06735	COG0758	DNA mediated transformation
SMB554_RS06740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMB554_RS06745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMB554_RS06750	COG0540	Belongs to the ATCase OTCase family
SMB554_RS06755	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS06775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMB554_RS06780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMB554_RS06785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMB554_RS06790	COG0154	amidase activity
SMB554_RS06795	COG3811	Belongs to the UPF0386 family
SMB554_RS06800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMB554_RS06820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SMB554_RS06825	COG0439	Biotin carboxylase
SMB554_RS06830	COG0511	ligase activity, forming carbon-carbon bonds
SMB554_RS06835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMB554_RS06850	COG0436	Aminotransferase
SMB554_RS06895	COG1530	ribonuclease E activity
SMB554_RS06905	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMB554_RS06910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMB554_RS06935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMB554_RS07015	COG4712	double-strand break repair protein
SMB554_RS07165	COG1783	phage Terminase large subunit
SMB554_RS07245	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS07280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMB554_RS07305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMB554_RS07315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMB554_RS07330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMB554_RS07340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS07360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMB554_RS07365	COG0081	regulation of translation
SMB554_RS07375	COG0222	ribosome binding
SMB554_RS07380	COG0085	RNA polymerase activity
SMB554_RS07385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMB554_RS07395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMB554_RS07400	COG0049	tRNA binding
SMB554_RS07405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMB554_RS07410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMB554_RS07415	COG0051	transcription antitermination factor activity, RNA binding
SMB554_RS07420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMB554_RS07425	COG0088	Forms part of the polypeptide exit tunnel
SMB554_RS07430	COG0089	rRNA binding
SMB554_RS07435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMB554_RS07440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMB554_RS07445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMB554_RS07450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMB554_RS07455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMB554_RS07460	COG0255	Belongs to the universal ribosomal protein uL29 family
SMB554_RS07465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMB554_RS07470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMB554_RS07475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMB554_RS07480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMB554_RS07485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMB554_RS07490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMB554_RS07495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMB554_RS07500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMB554_RS07505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMB554_RS07510	COG1841	ribosomal large subunit assembly
SMB554_RS07515	COG0200	Binds to the 23S rRNA
SMB554_RS07525	COG0563	adenylate kinase activity
SMB554_RS07530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMB554_RS07535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMB554_RS07540	COG0202	RNA polymerase activity
SMB554_RS07545	COG0203	ribosomal protein L17
SMB554_RS07555	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMB554_RS07560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMB554_RS07565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMB554_RS07570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMB554_RS07585	COG0546	phosphoglycolate phosphatase activity
SMB554_RS07590	COG0564	pseudouridine synthase activity
SMB554_RS07595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMB554_RS07600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMB554_RS07610	COG1671	Belongs to the UPF0178 family
SMB554_RS07615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SMB554_RS07625	COG0321	lipoyl(octanoyl) transferase activity
SMB554_RS07635	COG2766	serine protein kinase
SMB554_RS07640	COG2718	Belongs to the UPF0229 family
SMB554_RS07645	COG2719	SpoVR family
SMB554_RS07660	COG0242	peptide deformylase activity
SMB554_RS07665	COG2239	Acts as a magnesium transporter
SMB554_RS07690	COG1760	l-serine dehydratase
SMB554_RS07740	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SMB554_RS07750	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMB554_RS07760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMB554_RS07765	COG0302	gtp cyclohydrolase
SMB554_RS07775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMB554_RS07790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMB554_RS07830	COG0187	DNA topoisomerase II activity
SMB554_RS07855	COG0149	triose-phosphate isomerase activity
SMB554_RS07860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMB554_RS07865	COG0504	CTP synthase activity
SMB554_RS07875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMB554_RS07880	COG0148	phosphopyruvate hydratase activity
SMB554_RS07890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMB554_RS07895	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMB554_RS07895	COG0022	dehydrogenase e1 component
SMB554_RS07900	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMB554_RS07915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMB554_RS07925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMB554_RS07935	COG2867	negative regulation of translational initiation
SMB554_RS07940	COG1546	Belongs to the CinA family
SMB554_RS07940	COG1058	Belongs to the CinA family
SMB554_RS07945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMB554_RS07945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMB554_RS07955	COG3852	Histidine kinase
SMB554_RS07960	COG2204	response regulator
SMB554_RS07965	COG5000	phosphorelay sensor kinase activity
SMB554_RS07970	COG2204	response regulator
SMB554_RS07975	COG0569	domain protein
SMB554_RS07980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMB554_RS07985	COG1923	regulation of RNA biosynthetic process
SMB554_RS07990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMB554_RS07995	COG3415	Transposase
SMB554_RS07995	COG2801	Transposase and inactivated derivatives
SMB554_RS08000	COG3956	TIGRFAM MazG family protein
SMB554_RS08010	COG1648	precorrin-2 dehydrogenase activity
SMB554_RS08010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMB554_RS08020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMB554_RS08040	COG1126	abc transporter atp-binding protein
SMB554_RS08045	COG0765	amino acid transport
SMB554_RS08050	COG4597	amino acid ABC transporter
SMB554_RS08055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS08060	COG0626	cystathionine gamma-synthase activity
SMB554_RS08075	COG0596	Alpha beta hydrolase
SMB554_RS08080	COG1045	serine acetyltransferase
SMB554_RS08095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMB554_RS08115	COG0537	adenosine 5'-monophosphoramidase activity
SMB554_RS08145	COG0052	Belongs to the universal ribosomal protein uS2 family
SMB554_RS08150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMB554_RS08155	COG0528	UMP kinase activity
SMB554_RS08160	COG0233	cytoplasmic translational termination
SMB554_RS08165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMB554_RS08175	COG0750	zinc metalloprotease
SMB554_RS08185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMB554_RS08190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMB554_RS08195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMB554_RS08205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMB554_RS08220	COG0372	Belongs to the citrate synthase family
SMB554_RS08235	COG0848	biopolymer transport protein
SMB554_RS08240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMB554_RS08255	COG0525	valine-tRNA ligase activity
SMB554_RS08265	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SMB554_RS08275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMB554_RS08285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMB554_RS08290	COG0018	arginyl-trna synthetase
SMB554_RS08300	COG1472	Belongs to the glycosyl hydrolase 3 family
SMB554_RS08305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMB554_RS08310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMB554_RS08315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMB554_RS08320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMB554_RS08325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMB554_RS08330	COG0805	protein transport
SMB554_RS08335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMB554_RS08340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMB554_RS08345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMB554_RS08365	COG1862	Preprotein translocase
SMB554_RS08390	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SMB554_RS08415	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMB554_RS08420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMB554_RS08420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMB554_RS08425	COG0509	glycine decarboxylation via glycine cleavage system
SMB554_RS08430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMB554_RS08460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMB554_RS08475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMB554_RS08480	COG0629	single-stranded DNA binding
SMB554_RS08485	COG2095	MarC family integral membrane protein
SMB554_RS08490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMB554_RS08520	COG1902	pentaerythritol trinitrate reductase activity
SMB554_RS08530	COG0583	DNA-binding transcription factor activity
SMB554_RS08535	COG0492	ferredoxin-NADP+ reductase activity
SMB554_RS08540	COG1522	sequence-specific DNA binding
SMB554_RS08545	COG0463	Glycosyl transferase, family 2
SMB554_RS08550	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS08555	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS08560	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS08565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMB554_RS08580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMB554_RS08590	COG2321	neutral zinc metallopeptidase
SMB554_RS08600	COG0534	Mate efflux family protein
SMB554_RS08610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMB554_RS08625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMB554_RS08630	COG0343	queuine tRNA-ribosyltransferase activity
SMB554_RS08640	COG0300	oxidoreductase activity
SMB554_RS08665	COG1388	LysM domain
SMB554_RS08665	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS08695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMB554_RS08710	COG2801	Transposase and inactivated derivatives
SMB554_RS08720	COG0084	hydrolase, TatD family'
SMB554_RS08725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMB554_RS08740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMB554_RS08750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMB554_RS08790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMB554_RS08820	COG2076	Multidrug Resistance protein
SMB554_RS08840	COG4221	oxidoreductase activity
SMB554_RS08850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMB554_RS08855	COG2897	thiosulfate sulfurtransferase activity
SMB554_RS08870	COG0686	Belongs to the AlaDH PNT family
SMB554_RS08875	COG1522	sequence-specific DNA binding
SMB554_RS08880	COG0737	Belongs to the 5'-nucleotidase family
SMB554_RS08890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMB554_RS08895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMB554_RS08910	COG3795	YCII-related domain
SMB554_RS08935	COG0655	NAD(P)H dehydrogenase (quinone) activity
SMB554_RS08940	COG1058	Belongs to the CinA family
SMB554_RS08940	COG1546	Belongs to the CinA family
SMB554_RS08945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SMB554_RS08950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMB554_RS08950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMB554_RS08955	COG0347	Belongs to the P(II) protein family
SMB554_RS08960	COG0174	glutamine synthetase
SMB554_RS08990	COG3119	arylsulfatase activity
SMB554_RS09025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMB554_RS09030	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SMB554_RS09035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMB554_RS09045	COG3153	acetyltransferase
SMB554_RS09050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMB554_RS09055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMB554_RS09065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMB554_RS09070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMB554_RS09075	COG0134	indole-3-glycerol-phosphate synthase activity
SMB554_RS09080	COG0315	cyclic pyranopterin monophosphate synthase activity
SMB554_RS09085	COG0303	'Molybdopterin
SMB554_RS09095	COG1253	flavin adenine dinucleotide binding
SMB554_RS09100	COG2186	Transcriptional regulator
SMB554_RS09110	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS09115	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS09120	COG3845	ABC transporter
SMB554_RS09130	COG1183	phosphatidylcholine synthase activity
SMB554_RS09140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMB554_RS09145	COG0679	Auxin Efflux Carrier
SMB554_RS09150	COG0785	Cytochrome C biogenesis protein
SMB554_RS09380	COG0616	signal peptide processing
SMB554_RS09515	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS09525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMB554_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS09540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS09560	COG3958	Transketolase
SMB554_RS09565	COG3959	Transketolase, thiamine diphosphate binding domain
SMB554_RS09570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS09575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS09580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS09585	COG2084	Dehydrogenase
SMB554_RS09590	COG0583	DNA-binding transcription factor activity
SMB554_RS09595	COG3328	transposase activity
SMB554_RS09615	COG1522	sequence-specific DNA binding
SMB554_RS09655	COG0583	DNA-binding transcription factor activity
SMB554_RS09705	COG1278	Cold shock
SMB554_RS09750	COG0436	Aminotransferase
SMB554_RS09760	COG3243	poly(R)-hydroxyalkanoic acid synthase
SMB554_RS09765	COG1489	DNA binding
SMB554_RS09770	COG0024	Methionine aminopeptidase
SMB554_RS09775	COG2003	Belongs to the UPF0758 family
SMB554_RS09785	COG0316	Belongs to the HesB IscA family
SMB554_RS09790	COG2151	metal-sulfur cluster biosynthetic enzyme
SMB554_RS09795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMB554_RS09800	COG0719	Fe-S assembly protein
SMB554_RS09805	COG0396	ATPase activity
SMB554_RS09810	COG0719	Fe-S assembly protein
SMB554_RS09820	COG2945	thiolester hydrolase activity
SMB554_RS09830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SMB554_RS09835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMB554_RS09845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMB554_RS09850	COG2833	Protein of unknown function (DUF455)
SMB554_RS09855	COG0739	heme binding
SMB554_RS09860	COG0513	Belongs to the DEAD box helicase family
SMB554_RS09875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMB554_RS09880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMB554_RS09880	COG3608	succinylglutamate desuccinylase aspartoacylase
SMB554_RS09895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMB554_RS09900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMB554_RS09910	COG3191	aminopeptidase activity
SMB554_RS09930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMB554_RS09960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMB554_RS09965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMB554_RS10000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMB554_RS10005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMB554_RS10010	COG0047	phosphoribosylformylglycinamidine synthase activity
SMB554_RS10025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMB554_RS10035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMB554_RS10055	COG2814	Major facilitator Superfamily
SMB554_RS10065	COG0483	inositol monophosphate 1-phosphatase activity
SMB554_RS10070	COG0037	tRNA processing
SMB554_RS10075	COG2066	Belongs to the glutaminase family
SMB554_RS10080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMB554_RS10090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMB554_RS10095	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SMB554_RS10105	COG0538	isocitrate dehydrogenase activity
SMB554_RS10135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMB554_RS10140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMB554_RS10145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMB554_RS10150	COG2313	pseudouridylate synthase activity
SMB554_RS10180	COG3768	UPF0283 membrane protein
SMB554_RS10195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMB554_RS10200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMB554_RS10215	COG0633	Ferredoxin
SMB554_RS10235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMB554_RS10235	COG2857	Cytochrome c1
SMB554_RS10250	COG1132	(ABC) transporter
SMB554_RS10255	COG1132	(ABC) transporter
SMB554_RS10260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMB554_RS10265	COG0431	NADPH-dependent FMN reductase
SMB554_RS10270	COG0789	Transcriptional regulator
SMB554_RS10285	COG0408	coproporphyrinogen oxidase activity
SMB554_RS10295	COG3657	addiction module killer protein
SMB554_RS10300	COG3218	ABC-type transport auxiliary lipoprotein component
SMB554_RS10300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMB554_RS10310	COG1127	ABC transporter
SMB554_RS10315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMB554_RS10320	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS10325	COG2814	Major facilitator Superfamily
SMB554_RS10340	COG0280	phosphate acetyltransferase
SMB554_RS10340	COG0281	malic enzyme
SMB554_RS10345	COG2197	response regulator
SMB554_RS10360	COG0778	Nitroreductase
SMB554_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS10380	COG0823	Involved in the tonB-independent uptake of proteins
SMB554_RS10390	COG1368	sulfuric ester hydrolase activity
SMB554_RS10415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMB554_RS10430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMB554_RS10435	COG0546	phosphoglycolate phosphatase activity
SMB554_RS10440	COG2989	Protein conserved in bacteria
SMB554_RS10445	COG0114	fumarate hydratase activity
SMB554_RS10455	COG2267	carboxylic ester hydrolase activity
SMB554_RS10460	COG1846	Transcriptional regulator
SMB554_RS10470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMB554_RS10475	COG0697	spore germination
SMB554_RS10480	COG0746	molybdenum cofactor guanylyltransferase activity
SMB554_RS10485	COG1763	Mo-molybdopterin cofactor biosynthetic process
SMB554_RS10510	COG5425	PFAM Usg family protein
SMB554_RS10515	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS10530	COG2084	Dehydrogenase
SMB554_RS10540	COG1522	sequence-specific DNA binding
SMB554_RS10545	COG1573	uracil-dna glycosylase
SMB554_RS10560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMB554_RS10565	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMB554_RS10570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMB554_RS10585	COG0842	Transport permease protein
SMB554_RS10590	COG1131	(ABC) transporter
SMB554_RS10595	COG0640	Transcriptional regulator
SMB554_RS10650	COG0556	nucleotide-excision repair
SMB554_RS10660	COG0484	heat shock protein binding
SMB554_RS10680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMB554_RS10710	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMB554_RS10720	COG0735	belongs to the Fur family
SMB554_RS10725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMB554_RS10730	COG1121	(ABC) transporter
SMB554_RS10745	COG3507	Belongs to the glycosyl hydrolase 43 family
SMB554_RS10755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS10760	COG2801	Transposase and inactivated derivatives
SMB554_RS10760	COG3415	Transposase
SMB554_RS10770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SMB554_RS10775	COG0667	Aldo Keto reductase
SMB554_RS10790	COG3250	beta-galactosidase activity
SMB554_RS10795	COG3842	ATPase activity
SMB554_RS10800	COG0395	ABC-type sugar transport system, permease component
SMB554_RS10805	COG1175	transmembrane transport
SMB554_RS10825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SMB554_RS10830	COG1115	amino acid carrier protein
SMB554_RS10855	COG1560	Kdo2-lipid A biosynthetic process
SMB554_RS10865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMB554_RS10875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMB554_RS10880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMB554_RS10885	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMB554_RS10895	COG1797	cobyrinic acid a,c-diamide synthase activity
SMB554_RS10915	COG4172	Belongs to the ABC transporter superfamily
SMB554_RS10925	COG0747	negative chemotaxis
SMB554_RS10930	COG0601	transmembrane transport
SMB554_RS10935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS10980	COG0596	Alpha beta hydrolase
SMB554_RS10985	COG1492	cobalamin metabolic process
SMB554_RS11000	COG0517	IMP dehydrogenase activity
SMB554_RS11000	COG4175	Glycine betaine
SMB554_RS11005	COG3609	addiction module antidote protein, CC2985 family
SMB554_RS11025	COG1410	methionine synthase
SMB554_RS11025	COG0646	methionine synthase
SMB554_RS11045	COG3698	Phosphodiester glycosidase
SMB554_RS11055	COG5598	trimethylamine methyltransferase
SMB554_RS11060	COG5012	cobalamin binding
SMB554_RS11075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMB554_RS11110	COG0646	methionine synthase
SMB554_RS11110	COG1410	methionine synthase
SMB554_RS11135	COG0640	Transcriptional regulator
SMB554_RS11140	COG0583	DNA-binding transcription factor activity
SMB554_RS11180	COG0745	RESPONSE REGULATOR receiver
SMB554_RS11215	COG0861	Integral membrane protein TerC family
SMB554_RS11220	COG1196	nuclear chromosome segregation
SMB554_RS11220	COG3264	Mechanosensitive ion channel
SMB554_RS11235	COG0471	metal ion transport
SMB554_RS11235	COG3273	potassium ion transport
SMB554_RS11270	COG0463	Glycosyl transferase, family 2
SMB554_RS11395	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
SMB554_RS11400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS11430	COG0384	phenazine biosynthesis protein PhzF
SMB554_RS11470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SMB554_RS11485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMB554_RS11500	COG3842	ATPase activity
SMB554_RS11505	COG4149	molybdate abc transporter
SMB554_RS11520	COG1278	Cold shock
SMB554_RS11530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SMB554_RS11540	COG0667	Aldo Keto reductase
SMB554_RS11550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMB554_RS11560	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS11580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMB554_RS11590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS11595	COG1136	(ABC) transporter
SMB554_RS11595	COG0577	efflux transmembrane transporter activity
SMB554_RS11625	COG2271	Major facilitator Superfamily
SMB554_RS11640	COG1252	NADH dehydrogenase
SMB554_RS11645	COG1522	sequence-specific DNA binding
SMB554_RS11650	COG1794	racemase activity, acting on amino acids and derivatives
SMB554_RS11655	COG1733	regulation of RNA biosynthetic process
SMB554_RS11670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMB554_RS11675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SMB554_RS11720	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS11720	COG1672	PFAM Archaeal ATPase
SMB554_RS11725	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMB554_RS11730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMB554_RS11735	COG3180	Ammonia monooxygenase
SMB554_RS11755	COG1595	DNA-templated transcription, initiation
SMB554_RS11795	COG1278	Cold shock
SMB554_RS11800	COG0656	L-ascorbic acid biosynthetic process
SMB554_RS11805	COG0440	acetolactate synthase activity
SMB554_RS11810	COG0028	Belongs to the TPP enzyme family
SMB554_RS11830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMB554_RS11835	COG0560	Phosphoserine phosphatase
SMB554_RS11835	COG3830	Belongs to the UPF0237 family
SMB554_RS11840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMB554_RS11845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMB554_RS11860	COG0330	HflC and HflK could
SMB554_RS11880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMB554_RS11930	COG3385	transposase activity
SMB554_RS11940	COG0277	FAD linked oxidase domain protein
SMB554_RS11950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMB554_RS11985	COG3706	GGDEF domain
SMB554_RS12005	COG0835	chemotaxis
SMB554_RS12010	COG0840	transmembrane signaling receptor activity
SMB554_RS12020	COG1999	signal sequence binding
SMB554_RS12025	COG2264	protein methyltransferase activity
SMB554_RS12045	COG0006	proline dipeptidase activity
SMB554_RS12065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMB554_RS12070	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMB554_RS12080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMB554_RS12090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMB554_RS12100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMB554_RS12105	COG0849	cell division
SMB554_RS12110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SMB554_RS12115	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMB554_RS12120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMB554_RS12125	COG0477	Major facilitator Superfamily
SMB554_RS12130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMB554_RS12135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMB554_RS12140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMB554_RS12150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMB554_RS12155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMB554_RS12165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMB554_RS12180	COG0275	rRNA processing
SMB554_RS12185	COG2001	Belongs to the MraZ family
SMB554_RS12205	COG3023	N-Acetylmuramoyl-L-alanine amidase
SMB554_RS12210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMB554_RS12220	COG1280	lysine exporter protein (LysE YggA)
SMB554_RS12285	COG2267	carboxylic ester hydrolase activity
SMB554_RS12295	COG0028	Belongs to the TPP enzyme family
SMB554_RS12315	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS12320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS12335	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS12340	COG0174	glutamine synthetase
SMB554_RS12375	COG3842	ATPase activity
SMB554_RS12380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMB554_RS12390	COG4774	siderophore transport
SMB554_RS12395	COG3328	transposase activity
SMB554_RS12405	COG0149	triose-phosphate isomerase activity
SMB554_RS12410	COG1349	DNA-binding transcription factor activity
SMB554_RS12425	COG1070	Carbohydrate kinase
SMB554_RS12440	COG0235	Class ii aldolase
SMB554_RS12460	COG3842	ATPase activity
SMB554_RS12470	COG1175	transmembrane transport
SMB554_RS12475	COG1653	transport
SMB554_RS12485	COG2197	response regulator
SMB554_RS12490	COG3842	ATPase activity
SMB554_RS12505	COG1177	transmembrane transport
SMB554_RS12510	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS12520	COG3246	L-lysine catabolic process to acetate
SMB554_RS12525	COG0824	Thioesterase
SMB554_RS12525	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMB554_RS12530	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS12550	COG0747	negative chemotaxis
SMB554_RS12560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS12595	COG0583	DNA-binding transcription factor activity
SMB554_RS12600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SMB554_RS12605	COG3842	ATPase activity
SMB554_RS12610	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMB554_RS12615	COG1177	transmembrane transport
SMB554_RS12620	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS12685	COG1024	Enoyl-CoA hydratase
SMB554_RS12800	COG1696	Membrane protein involved in D-alanine export
SMB554_RS12835	COG2968	Membrane
SMB554_RS12850	COG0432	Pfam Uncharacterised protein family UPF0047
SMB554_RS12855	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMB554_RS12875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMB554_RS12880	COG1063	alcohol dehydrogenase
SMB554_RS12890	COG0514	ATP-dependent DNA helicase (RecQ)
SMB554_RS12895	COG0358	DNA primase activity
SMB554_RS12905	COG0505	Belongs to the CarA family
SMB554_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS12920	COG2084	Dehydrogenase
SMB554_RS12930	COG0436	Aminotransferase
SMB554_RS12945	COG2133	pyrroloquinoline quinone binding
SMB554_RS12955	COG1278	Cold shock
SMB554_RS12965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMB554_RS12985	COG1846	Transcriptional regulator
SMB554_RS12990	COG0745	RESPONSE REGULATOR receiver
SMB554_RS12995	COG2205	protein histidine kinase activity
SMB554_RS13000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMB554_RS13020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMB554_RS13030	COG1496	oxidoreductase activity
SMB554_RS13045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMB554_RS13050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMB554_RS13060	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS13070	COG3135	benzoate transporter
SMB554_RS13075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMB554_RS13080	COG0193	aminoacyl-tRNA hydrolase activity
SMB554_RS13085	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMB554_RS13105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMB554_RS13130	COG0714	Associated with various cellular activities
SMB554_RS13155	COG0435	Glutathione S-transferase
SMB554_RS13180	COG1595	DNA-templated transcription, initiation
SMB554_RS13190	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
SMB554_RS13195	COG4423	Transcription factor
SMB554_RS13200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMB554_RS13210	COG0740	serine-type endopeptidase activity
SMB554_RS13225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMB554_RS13230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMB554_RS13235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMB554_RS13235	COG0512	Glutamine amidotransferase of anthranilate synthase
SMB554_RS13250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SMB554_RS13265	COG3385	transposase activity
SMB554_RS13270	COG2852	Protein conserved in bacteria
SMB554_RS13290	COG1435	thymidine kinase activity
SMB554_RS13325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMB554_RS13330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SMB554_RS13335	COG0366	Alpha amylase catalytic
SMB554_RS13340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMB554_RS13345	COG4608	Belongs to the ABC transporter superfamily
SMB554_RS13350	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS13355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS13360	COG0601	transmembrane transport
SMB554_RS13375	COG2076	Multidrug Resistance protein
SMB554_RS13395	COG2346	COG2346, Truncated hemoglobins
SMB554_RS13445	COG4558	Periplasmic binding protein
SMB554_RS13450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMB554_RS13455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMB554_RS13470	COG3920	Histidine kinase
SMB554_RS13470	COG2202	Pas domain
SMB554_RS13485	COG0784	Response regulator, receiver
SMB554_RS13515	COG0395	ABC-type sugar transport system, permease component
SMB554_RS13520	COG1175	transmembrane transport
SMB554_RS13545	COG1063	alcohol dehydrogenase
SMB554_RS13550	COG0583	DNA-binding transcription factor activity
SMB554_RS13565	COG1309	transcriptional regulator
SMB554_RS13595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMB554_RS13600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMB554_RS13605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMB554_RS13620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SMB554_RS13625	COG0830	nickel cation binding
SMB554_RS13630	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SMB554_RS13660	COG0804	urea catabolic process
SMB554_RS13665	COG1442	glycosyl transferase family 8
SMB554_RS13670	COG3755	Protein conserved in bacteria
SMB554_RS13675	COG0832	Belongs to the urease beta subunit family
SMB554_RS13680	COG3813	Protein conserved in bacteria
SMB554_RS13685	COG0831	urea catabolic process
SMB554_RS13690	COG0829	nickel cation binding
SMB554_RS13695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMB554_RS13705	COG1846	Transcriptional regulator
SMB554_RS13745	COG0784	Response regulator, receiver
SMB554_RS13750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMB554_RS13760	COG0400	carboxylic ester hydrolase activity
SMB554_RS13785	COG0346	lactoylglutathione lyase activity
SMB554_RS13790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMB554_RS13800	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMB554_RS13805	COG3842	ATPase activity
SMB554_RS13825	COG0436	Aminotransferase
SMB554_RS13845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS13850	COG0174	glutamine synthetase
SMB554_RS13860	COG1725	Transcriptional regulator
SMB554_RS13865	COG0626	cystathionine gamma-synthase activity
SMB554_RS13880	COG0395	ABC-type sugar transport system, permease component
SMB554_RS13885	COG3842	ATPase activity
SMB554_RS13895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMB554_RS13900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMB554_RS13905	COG1845	cytochrome c oxidase, subunit III
SMB554_RS13930	COG1129	ABC transporter
SMB554_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS13955	COG1802	Transcriptional regulator
SMB554_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS13980	COG2140	Oxalate decarboxylase
SMB554_RS13985	COG0800	Aldolase
SMB554_RS13995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMB554_RS14000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMB554_RS14005	COG1737	Transcriptional regulator
SMB554_RS14010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMB554_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS14030	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS14035	COG1129	ABC transporter
SMB554_RS14040	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS14045	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS14050	COG2188	Transcriptional regulator
SMB554_RS14055	COG1070	Carbohydrate kinase
SMB554_RS14060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMB554_RS14065	COG0477	Major facilitator Superfamily
SMB554_RS14105	COG0174	glutamine synthetase
SMB554_RS14120	COG1335	isochorismatase
SMB554_RS14125	COG0683	leucine binding
SMB554_RS14150	COG1335	isochorismatase
SMB554_RS14160	COG0402	S-adenosylhomocysteine deaminase activity
SMB554_RS14180	COG0601	transmembrane transport
SMB554_RS14185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS14195	COG1228	amidohydrolase
SMB554_RS14200	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS14205	COG4608	Belongs to the ABC transporter superfamily
SMB554_RS14210	COG1802	Transcriptional regulator
SMB554_RS14225	COG0723	plastoquinol--plastocyanin reductase activity
SMB554_RS14230	COG0583	DNA-binding transcription factor activity
SMB554_RS14235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMB554_RS14275	COG0739	heme binding
SMB554_RS14280	COG0542	response to heat
SMB554_RS14295	COG2890	protein-(glutamine-N5) methyltransferase activity
SMB554_RS14300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMB554_RS14305	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
SMB554_RS14310	COG0527	aspartate kinase activity
SMB554_RS14320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMB554_RS14330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMB554_RS14345	COG2226	methyltransferase
SMB554_RS14360	COG0494	nUDIX hydrolase
SMB554_RS14370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMB554_RS14375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMB554_RS14380	COG0653	protein targeting
SMB554_RS14400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMB554_RS14435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMB554_RS14445	COG0300	oxidoreductase activity
SMB554_RS14455	COG2096	Adenosyltransferase
SMB554_RS14465	COG2086	electron transfer activity
SMB554_RS14470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMB554_RS14475	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMB554_RS14480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMB554_RS14485	COG0165	Argininosuccinate lyase
SMB554_RS14505	COG3385	transposase activity
SMB554_RS14525	COG2884	Cell division ATP-binding protein ftsE
SMB554_RS14545	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
SMB554_RS14555	COG0287	Prephenate dehydrogenase
SMB554_RS14560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMB554_RS14565	COG2226	methyltransferase
SMB554_RS14570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMB554_RS14590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMB554_RS14595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMB554_RS14625	COG4536	flavin adenine dinucleotide binding
SMB554_RS14630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMB554_RS14635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMB554_RS14645	COG3609	addiction module antidote protein, CC2985 family
SMB554_RS14655	COG4974	Belongs to the 'phage' integrase family
SMB554_RS14660	COG0825	malonyl-CoA metabolic process
SMB554_RS14665	COG3034	peptidoglycan biosynthetic process
SMB554_RS14685	COG0523	cobalamin synthesis protein
SMB554_RS14690	COG1686	Belongs to the peptidase S11 family
SMB554_RS14695	COG1473	amidohydrolase
SMB554_RS14705	COG1064	alcohol dehydrogenase
SMB554_RS14710	COG2207	Transcriptional regulator
SMB554_RS14715	COG1522	sequence-specific DNA binding
SMB554_RS14720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMB554_RS14725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS14730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMB554_RS14740	COG0402	S-adenosylhomocysteine deaminase activity
SMB554_RS14750	COG4176	ABC-type proline glycine betaine transport system permease component
SMB554_RS14755	COG4175	Glycine betaine
SMB554_RS14755	COG0517	IMP dehydrogenase activity
SMB554_RS14760	COG2986	histidine ammonia-lyase
SMB554_RS14765	COG3314	Sporulation integral membrane protein YlbJ
SMB554_RS14820	COG0482	sulfurtransferase activity
SMB554_RS14880	COG0564	pseudouridine synthase activity
SMB554_RS14885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMB554_RS14895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMB554_RS14905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMB554_RS14930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMB554_RS14935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMB554_RS14940	COG0037	tRNA processing
SMB554_RS14950	COG2885	chlorophyll binding
SMB554_RS14955	COG0823	Involved in the tonB-independent uptake of proteins
SMB554_RS14980	COG0824	Thioesterase
SMB554_RS15000	COG1408	metallophosphoesterase
SMB554_RS15005	COG2255	four-way junction helicase activity
SMB554_RS15010	COG0632	four-way junction helicase activity
SMB554_RS15015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMB554_RS15020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMB554_RS15025	COG0217	transcriptional regulatory protein
SMB554_RS15040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS15045	COG1692	metallophosphoesterase
SMB554_RS15095	COG0126	phosphoglycerate kinase activity
SMB554_RS15100	COG3328	transposase activity
SMB554_RS15105	COG3588	fructose-bisphosphate aldolase
SMB554_RS15110	COG0384	phenazine biosynthesis protein PhzF
SMB554_RS15140	COG0254	rRNA binding
SMB554_RS15145	COG1132	(ABC) transporter
SMB554_RS15160	COG0483	inositol monophosphate 1-phosphatase activity
SMB554_RS15180	COG0640	Transcriptional regulator
SMB554_RS15195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMB554_RS15200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SMB554_RS15205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMB554_RS15210	COG0457	Tetratricopeptide repeat
SMB554_RS15215	COG0469	pyruvate kinase activity
SMB554_RS15235	COG3750	Belongs to the UPF0335 family
SMB554_RS15240	COG3108	Peptidase M15
SMB554_RS15245	COG2204	response regulator
SMB554_RS15255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMB554_RS15270	COG5310	Homospermidine synthase
SMB554_RS15280	COG0737	Belongs to the 5'-nucleotidase family
SMB554_RS15285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMB554_RS15290	COG0330	HflC and HflK could
SMB554_RS15295	COG1585	Membrane protein implicated in regulation of membrane protease activity
SMB554_RS15305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMB554_RS15310	COG2951	lytic endotransglycosylase activity
SMB554_RS15325	COG0069	glutamate synthase activity
SMB554_RS15325	COG0067	glutamate synthase
SMB554_RS15325	COG0070	glutamate synthase
SMB554_RS15345	COG2197	response regulator
SMB554_RS15350	COG2267	carboxylic ester hydrolase activity
SMB554_RS15355	COG0601	transmembrane transport
SMB554_RS15360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS15365	COG4172	Belongs to the ABC transporter superfamily
SMB554_RS15375	COG0071	Belongs to the small heat shock protein (HSP20) family
SMB554_RS15405	COG0129	dihydroxy-acid dehydratase activity
SMB554_RS15465	COG0583	DNA-binding transcription factor activity
SMB554_RS15470	COG0667	Aldo Keto reductase
SMB554_RS15480	COG1305	Transglutaminase-like
SMB554_RS15490	COG0058	SHG alpha-glucan phosphorylase activity
SMB554_RS15495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMB554_RS15500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMB554_RS15505	COG0297	glycogen (starch) synthase activity
SMB554_RS15510	COG0033	Phosphoglucomutase
SMB554_RS15515	COG1523	belongs to the glycosyl hydrolase 13 family
SMB554_RS15540	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMB554_RS15540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMB554_RS15550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS15560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SMB554_RS15600	COG5001	Diguanylate cyclase
SMB554_RS15605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMB554_RS15610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMB554_RS15615	COG1609	Transcriptional regulator
SMB554_RS15620	COG1846	Transcriptional regulator
SMB554_RS15630	COG0523	cobalamin synthesis protein
SMB554_RS15645	COG1280	lysine exporter protein (LysE YggA)
SMB554_RS15660	COG0583	DNA-binding transcription factor activity
SMB554_RS15670	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMB554_RS15705	COG0800	Aldolase
SMB554_RS15710	COG2954	triphosphatase activity
SMB554_RS15720	COG1054	Belongs to the UPF0176 family
SMB554_RS15730	COG2011	ABC-type metal ion transport system permease component
SMB554_RS15735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMB554_RS15745	COG0673	inositol 2-dehydrogenase activity
SMB554_RS15755	COG2115	Belongs to the xylose isomerase family
SMB554_RS15760	COG1070	Carbohydrate kinase
SMB554_RS15765	COG1609	Transcriptional regulator
SMB554_RS15785	COG1309	transcriptional regulator
SMB554_RS15790	COG3708	Transcriptional regulator
SMB554_RS15790	COG2207	Transcriptional regulator
SMB554_RS15795	COG1253	flavin adenine dinucleotide binding
SMB554_RS15800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMB554_RS15805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMB554_RS15825	COG1793	dna ligase
SMB554_RS15825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMB554_RS15835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMB554_RS15835	COG2111	Na H antiporter
SMB554_RS15840	COG1006	Multisubunit Na H antiporter MnhC subunit
SMB554_RS15845	COG0651	ATP synthesis coupled electron transport
SMB554_RS15850	COG1863	multisubunit Na H antiporter MnhE subunit
SMB554_RS15855	COG2212	antiporter activity
SMB554_RS15860	COG1320	monovalent cation:proton antiporter activity
SMB554_RS15870	COG0583	DNA-binding transcription factor activity
SMB554_RS15915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMB554_RS15920	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMB554_RS15930	COG4149	molybdate abc transporter
SMB554_RS15935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SMB554_RS15940	COG3585	molybdate ion transport
SMB554_RS15940	COG2005	Transcriptional regulator
SMB554_RS15955	COG0022	dehydrogenase e1 component
SMB554_RS15975	COG0625	glutathione transferase activity
SMB554_RS15985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMB554_RS16005	COG2197	response regulator
SMB554_RS16025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS16050	COG5001	Diguanylate cyclase
SMB554_RS16050	COG3300	MHYT domain
SMB554_RS16060	COG1802	Transcriptional regulator
SMB554_RS16070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMB554_RS16085	COG1126	abc transporter atp-binding protein
SMB554_RS16095	COG0765	amino acid transport
SMB554_RS16100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS16105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS16115	COG0584	glycerophosphoryl diester phosphodiesterase
SMB554_RS16120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS16140	COG0747	negative chemotaxis
SMB554_RS16145	COG2390	Transcriptional regulator
SMB554_RS16180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMB554_RS16205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SMB554_RS16210	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SMB554_RS16235	COG2852	Protein conserved in bacteria
SMB554_RS16240	COG1196	nuclear chromosome segregation
SMB554_RS16295	COG1484	DNA-dependent DNA replication
SMB554_RS16305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMB554_RS16370	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS16385	COG3328	transposase activity
SMB554_RS16395	COG2942	2-epimerase
SMB554_RS16400	COG4702	Belongs to the UPF0303 family
SMB554_RS16405	COG1940	carbohydrate kinase activity
SMB554_RS16435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMB554_RS16440	COG0156	8-amino-7-oxononanoate synthase activity
SMB554_RS16470	COG2267	carboxylic ester hydrolase activity
SMB554_RS16505	COG0010	Belongs to the arginase family
SMB554_RS16510	COG0835	chemotaxis
SMB554_RS16525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMB554_RS16530	COG3383	formate dehydrogenase (NAD+) activity
SMB554_RS16550	COG0583	DNA-binding transcription factor activity
SMB554_RS16570	COG3842	ATPase activity
SMB554_RS16575	COG3842	ATPase activity
SMB554_RS16585	COG0395	ABC-type sugar transport system, permease component
SMB554_RS16600	COG2233	PERMEase
SMB554_RS16605	COG2233	PERMEase
SMB554_RS16620	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMB554_RS16625	COG1121	(ABC) transporter
SMB554_RS16630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMB554_RS16635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMB554_RS16655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMB554_RS16660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMB554_RS16665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMB554_RS16670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMB554_RS16675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMB554_RS16690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMB554_RS16710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMB554_RS16720	COG4974	Belongs to the 'phage' integrase family
SMB554_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS16750	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMB554_RS16755	COG0567	Dehydrogenase, E1 component
SMB554_RS16760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMB554_RS16765	COG0045	succinate-CoA ligase (ADP-forming) activity
SMB554_RS16770	COG0039	L-malate dehydrogenase activity
SMB554_RS16775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SMB554_RS16785	COG3549	Plasmid maintenance system killer
SMB554_RS16790	COG2845	Protein of unknown function (DUF459)
SMB554_RS16800	COG0395	ABC-type sugar transport system, permease component
SMB554_RS16805	COG1175	transmembrane transport
SMB554_RS16830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMB554_RS16850	COG2009	succinate dehydrogenase
SMB554_RS16875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMB554_RS16880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMB554_RS16885	COG0181	hydroxymethylbilane synthase activity
SMB554_RS16910	COG0519	Catalyzes the synthesis of GMP from XMP
SMB554_RS16910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMB554_RS16925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMB554_RS16940	COG1217	gtp-binding protein TYPA
SMB554_RS16950	COG4249	Peptidase C14 caspase catalytic subunit p20
SMB554_RS16980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMB554_RS16985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMB554_RS17000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMB554_RS17005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMB554_RS17010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMB554_RS17015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMB554_RS17020	COG0799	negative regulation of ribosome biogenesis
SMB554_RS17025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMB554_RS17035	COG0793	Belongs to the peptidase S41A family
SMB554_RS17040	COG2861	carbohydrate metabolic process
SMB554_RS17045	COG0494	nUDIX hydrolase
SMB554_RS17060	COG0587	DNA-directed DNA polymerase activity
SMB554_RS17090	COG0066	3-isopropylmalate dehydratase activity
SMB554_RS17095	COG0251	oxidation-reduction process
SMB554_RS17100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SMB554_RS17110	COG0523	cobalamin synthesis protein
SMB554_RS17125	COG3118	belongs to the thioredoxin family
SMB554_RS17130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMB554_RS17135	COG2835	tetraacyldisaccharide 4'-kinase activity
SMB554_RS17145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMB554_RS17150	COG1946	Acyl-CoA thioesterase
SMB554_RS17155	COG0347	Belongs to the P(II) protein family
SMB554_RS17160	COG0004	ammonium transporteR
SMB554_RS17165	COG1674	ftsk spoiiie
SMB554_RS17170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SMB554_RS17190	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS17195	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS17200	COG1129	ABC transporter
SMB554_RS17205	COG1940	carbohydrate kinase activity
SMB554_RS17210	COG1940	carbohydrate kinase activity
SMB554_RS17225	COG0745	RESPONSE REGULATOR receiver
SMB554_RS17240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMB554_RS17255	COG0477	Major facilitator Superfamily
SMB554_RS17260	COG0137	argininosuccinate synthase activity
SMB554_RS17275	COG4120	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS17285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMB554_RS17305	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMB554_RS17310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SMB554_RS17320	COG4181	ATPase activity
SMB554_RS17330	COG0670	Belongs to the BI1 family
SMB554_RS17340	COG0740	serine-type endopeptidase activity
SMB554_RS17350	COG0640	Transcriptional regulator
SMB554_RS17365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMB554_RS17370	COG4133	protoheme IX ABC transporter activity
SMB554_RS17375	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMB554_RS17380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMB554_RS17400	COG2917	probably involved in intracellular septation
SMB554_RS17405	COG0552	protein localization to endoplasmic reticulum
SMB554_RS17410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMB554_RS17415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMB554_RS17420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMB554_RS17425	COG1605	Chorismate mutase
SMB554_RS17425	COG0287	Prephenate dehydrogenase
SMB554_RS17430	COG0228	four-way junction DNA binding
SMB554_RS17435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMB554_RS17440	COG0336	Belongs to the RNA methyltransferase TrmD family
SMB554_RS17450	COG0335	large ribosomal subunit rRNA binding
SMB554_RS17460	COG0765	amino acid transport
SMB554_RS17465	COG0488	(ABC) transporter
SMB554_RS17490	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
SMB554_RS17500	COG3385	transposase activity
SMB554_RS17505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMB554_RS17510	COG1329	Transcriptional regulator
SMB554_RS17515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SMB554_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS17535	COG0183	Belongs to the thiolase family
SMB554_RS17540	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
SMB554_RS17545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMB554_RS17550	COG0625	glutathione transferase activity
SMB554_RS17555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMB554_RS17560	COG0142	geranyltranstransferase activity
SMB554_RS17565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMB554_RS17575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMB554_RS17580	COG2223	nitrite transmembrane transporter activity
SMB554_RS17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS17595	COG0765	amino acid transport
SMB554_RS17600	COG1126	abc transporter atp-binding protein
SMB554_RS17605	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SMB554_RS17615	COG1132	(ABC) transporter
SMB554_RS17630	COG3459	Glycosyltransferase 36 associated
SMB554_RS17645	COG5383	Protein conserved in bacteria
SMB554_RS17660	COG0436	Aminotransferase
SMB554_RS17670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMB554_RS17685	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS17695	COG3842	ATPase activity
SMB554_RS17700	COG0395	ABC-type sugar transport system, permease component
SMB554_RS17705	COG1175	transmembrane transport
SMB554_RS17710	COG1653	transport
SMB554_RS17715	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS17720	COG1024	Enoyl-CoA hydratase
SMB554_RS17730	COG0673	inositol 2-dehydrogenase activity
SMB554_RS17735	COG1609	Transcriptional regulator
SMB554_RS17745	COG0339	signal peptide processing
SMB554_RS17755	COG0473	3-isopropylmalate dehydrogenase activity
SMB554_RS17760	COG0671	phosphoesterase, PA-phosphatase related
SMB554_RS17785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMB554_RS17800	COG0288	reversible hydration of carbon dioxide
SMB554_RS17810	COG2902	Dehydrogenase
SMB554_RS17825	COG0138	bifunctional purine biosynthesis protein purh
SMB554_RS17835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMB554_RS17835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMB554_RS17840	COG0501	Belongs to the peptidase M48B family
SMB554_RS17850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMB554_RS17870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMB554_RS17875	COG0495	leucyl-tRNA aminoacylation
SMB554_RS17900	COG0357	Ribosomal RNA small subunit methyltransferase G
SMB554_RS17905	COG0445	tRNA wobble uridine modification
SMB554_RS17910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMB554_RS17915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMB554_RS17920	COG1981	membrane
SMB554_RS17925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMB554_RS17935	COG0243	molybdopterin cofactor binding
SMB554_RS17935	COG3383	formate dehydrogenase (NAD+) activity
SMB554_RS17940	COG0243	molybdopterin cofactor binding
SMB554_RS17940	COG3383	formate dehydrogenase (NAD+) activity
SMB554_RS17945	COG0437	4 iron, 4 sulfur cluster binding
SMB554_RS17950	COG2864	formate dehydrogenase
SMB554_RS18015	COG1305	Transglutaminase-like
SMB554_RS18040	COG0488	(ABC) transporter
SMB554_RS18045	COG0583	DNA-binding transcription factor activity
SMB554_RS18060	COG1609	Transcriptional regulator
SMB554_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS18085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMB554_RS18095	COG1024	Enoyl-CoA hydratase
SMB554_RS18100	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS18110	COG1129	ABC transporter
SMB554_RS18115	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS18150	COG1802	Transcriptional regulator
SMB554_RS18180	COG1609	Transcriptional regulator
SMB554_RS18185	COG0765	amino acid transport
SMB554_RS18190	COG0765	amino acid transport
SMB554_RS18195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS18200	COG1126	abc transporter atp-binding protein
SMB554_RS18205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMB554_RS18215	COG0251	oxidation-reduction process
SMB554_RS18235	COG0583	DNA-binding transcription factor activity
SMB554_RS18240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SMB554_RS18245	COG0747	negative chemotaxis
SMB554_RS18250	COG0601	transmembrane transport
SMB554_RS18255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS18260	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS18265	COG4172	Belongs to the ABC transporter superfamily
SMB554_RS18270	COG4691	Plasmid stability protein
SMB554_RS18275	COG1487	ribonuclease activity
SMB554_RS18335	COG1278	Cold shock
SMB554_RS18345	COG3239	Fatty acid desaturase
SMB554_RS18365	COG0628	permease
SMB554_RS18370	COG3300	MHYT domain
SMB554_RS18370	COG5001	Diguanylate cyclase
SMB554_RS18380	COG1404	Belongs to the peptidase S8 family
SMB554_RS18405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMB554_RS18410	COG0318	PFAM AMP-dependent synthetase and ligase
SMB554_RS18430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS18435	COG1802	Transcriptional regulator
SMB554_RS18440	COG4964	Belongs to the GSP D family
SMB554_RS18455	COG4106	trans-aconitate 2-methyltransferase activity
SMB554_RS18460	COG2226	methyltransferase
SMB554_RS18495	COG0583	DNA-binding transcription factor activity
SMB554_RS18505	COG1278	Cold shock
SMB554_RS18510	COG0477	Major facilitator Superfamily
SMB554_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS18560	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS18565	COG1129	ABC transporter
SMB554_RS18570	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS18575	COG4585	Histidine kinase
SMB554_RS18605	COG1129	ABC transporter
SMB554_RS18620	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS18625	COG1802	Transcriptional regulator
SMB554_RS18645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMB554_RS18655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMB554_RS18665	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SMB554_RS18670	COG0129	dihydroxy-acid dehydratase activity
SMB554_RS18675	COG2084	Dehydrogenase
SMB554_RS18680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS18685	COG0277	FAD linked oxidase domain protein
SMB554_RS18690	COG2186	Transcriptional regulator
SMB554_RS18700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMB554_RS18705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS18710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS18730	COG0657	acetylesterase activity
SMB554_RS18740	COG1454	alcohol dehydrogenase
SMB554_RS18745	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMB554_RS18750	COG1802	Transcriptional regulator
SMB554_RS18755	COG1129	ABC transporter
SMB554_RS18760	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS18765	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS18770	COG0693	protein deglycase activity
SMB554_RS18845	COG0583	DNA-binding transcription factor activity
SMB554_RS18855	COG3077	Addiction module antitoxin, RelB DinJ family
SMB554_RS18955	COG2910	NAD(P)H-binding
SMB554_RS18960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMB554_RS18975	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS18990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS19005	COG0667	Aldo Keto reductase
SMB554_RS19035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SMB554_RS19050	COG3920	Histidine kinase
SMB554_RS19055	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SMB554_RS19105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMB554_RS19110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMB554_RS19120	COG1744	ABC transporter substrate-binding protein PnrA-like
SMB554_RS19125	COG3845	ABC transporter
SMB554_RS19130	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS19135	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS19145	COG1957	nucleoside hydrolase
SMB554_RS19150	COG0402	S-adenosylhomocysteine deaminase activity
SMB554_RS19155	COG3609	addiction module antidote protein, CC2985 family
SMB554_RS19190	COG2801	Transposase and inactivated derivatives
SMB554_RS19200	COG1063	alcohol dehydrogenase
SMB554_RS19205	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS19205	COG3321	synthase
SMB554_RS19205	COG0604	alcohol dehydrogenase
SMB554_RS19235	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS19240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMB554_RS19245	COG0277	FAD linked oxidase domain protein
SMB554_RS19250	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMB554_RS19260	COG3311	Transcriptional regulator
SMB554_RS19285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMB554_RS19340	COG0251	oxidation-reduction process
SMB554_RS19355	COG1414	Transcriptional regulator
SMB554_RS19365	COG0583	DNA-binding transcription factor activity
SMB554_RS19370	COG4638	Rieske (2fe-2S)
SMB554_RS19385	COG2267	carboxylic ester hydrolase activity
SMB554_RS19400	COG2267	carboxylic ester hydrolase activity
SMB554_RS19405	COG1309	transcriptional regulator
SMB554_RS19420	COG1278	Cold shock
SMB554_RS19430	COG0492	ferredoxin-NADP+ reductase activity
SMB554_RS19450	COG1733	regulation of RNA biosynthetic process
SMB554_RS19460	COG0583	DNA-binding transcription factor activity
SMB554_RS19465	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS19510	COG3177	Filamentation induced by cAMP protein fic
SMB554_RS19525	COG1280	lysine exporter protein (LysE YggA)
SMB554_RS19560	COG1672	PFAM Archaeal ATPase
SMB554_RS19560	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS19575	COG3119	arylsulfatase activity
SMB554_RS19605	COG0714	Associated with various cellular activities
SMB554_RS19610	COG2985	domain, Protein
SMB554_RS19620	COG2985	domain, Protein
SMB554_RS19630	COG4191	Histidine kinase
SMB554_RS19635	COG4566	intracellular signal transduction
SMB554_RS19640	COG2205	protein histidine kinase activity
SMB554_RS19640	COG0784	Response regulator, receiver
SMB554_RS19640	COG2198	Histidine kinase
SMB554_RS19670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMB554_RS19680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMB554_RS19700	COG1116	anion transmembrane transporter activity
SMB554_RS19710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMB554_RS19715	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMB554_RS19735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMB554_RS19765	COG0625	glutathione transferase activity
SMB554_RS19795	COG0747	negative chemotaxis
SMB554_RS19805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS19850	COG3278	Belongs to the heme-copper respiratory oxidase family
SMB554_RS19865	COG2010	Cytochrome c
SMB554_RS19900	COG3047	cAMP biosynthetic process
SMB554_RS19900	COG2885	chlorophyll binding
SMB554_RS19920	COG0668	transmembrane transport
SMB554_RS20010	COG2826	transposase and inactivated derivatives, IS30 family
SMB554_RS20015	COG3005	denitrification pathway
SMB554_RS20040	COG0628	permease
SMB554_RS20080	COG0531	amino acid
SMB554_RS20085	COG1982	Orn Lys Arg decarboxylase major
SMB554_RS20100	COG0531	amino acid
SMB554_RS20155	COG3734	2-keto-3-deoxy-galactonokinase
SMB554_RS20165	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS20170	COG1653	transport
SMB554_RS20175	COG1175	transmembrane transport
SMB554_RS20180	COG0395	ABC-type sugar transport system, permease component
SMB554_RS20195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS20255	COG1278	Cold shock
SMB554_RS20280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMB554_RS20300	COG0583	DNA-binding transcription factor activity
SMB554_RS20305	COG4638	Rieske (2fe-2S)
SMB554_RS20345	COG3328	transposase activity
SMB554_RS20355	COG3328	transposase activity
SMB554_RS20365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SMB554_RS20390	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS20395	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMB554_RS20415	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMB554_RS20430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMB554_RS20435	COG0527	aspartate kinase activity
SMB554_RS20445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMB554_RS20455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMB554_RS20460	COG0492	ferredoxin-NADP+ reductase activity
SMB554_RS20475	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMB554_RS20490	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMB554_RS20495	COG1509	lysine 2,3-aminomutase activity
SMB554_RS20520	COG3328	transposase activity
SMB554_RS20530	COG1735	metal-dependent hydrolase with the TIM-barrel fold
SMB554_RS20535	COG1802	Transcriptional regulator
SMB554_RS20540	COG0154	amidase activity
SMB554_RS20545	COG0747	negative chemotaxis
SMB554_RS20550	COG0601	transmembrane transport
SMB554_RS20555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS20560	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS20565	COG4608	Belongs to the ABC transporter superfamily
SMB554_RS20625	COG0601	transmembrane transport
SMB554_RS20630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS20635	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS20640	COG4608	Belongs to the ABC transporter superfamily
SMB554_RS20660	COG1484	DNA-dependent DNA replication
SMB554_RS20765	COG1484	DNA-dependent DNA replication
SMB554_RS20770	COG4584	PFAM Integrase catalytic
SMB554_RS20795	COG2267	carboxylic ester hydrolase activity
SMB554_RS20805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMB554_RS20810	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS20830	COG0395	ABC-type sugar transport system, permease component
SMB554_RS20910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMB554_RS20915	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMB554_RS20925	COG1433	Dinitrogenase iron-molybdenum cofactor
SMB554_RS20930	COG5420	small protein containing a coiled-coil domain
SMB554_RS20935	COG3383	formate dehydrogenase (NAD+) activity
SMB554_RS21015	COG0175	sulfate reduction
SMB554_RS21020	COG2895	sulfate adenylyltransferase (ATP) activity
SMB554_RS21020	COG0529	Catalyzes the synthesis of activated sulfate
SMB554_RS21080	COG2963	transposase activity
SMB554_RS21085	COG0582	viral genome integration into host DNA
SMB554_RS21090	COG0582	viral genome integration into host DNA
SMB554_RS21095	COG0582	viral genome integration into host DNA
SMB554_RS21150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMB554_RS21180	COG3012	SEC-C Motif Domain Protein
SMB554_RS21265	COG3505	Type IV secretory pathway VirD4
SMB554_RS21285	COG0668	transmembrane transport
SMB554_RS21320	COG1177	transmembrane transport
SMB554_RS21325	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMB554_RS21330	COG3842	ATPase activity
SMB554_RS21340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMB554_RS21355	COG0745	RESPONSE REGULATOR receiver
SMB554_RS21370	COG0745	RESPONSE REGULATOR receiver
SMB554_RS21375	COG0156	8-amino-7-oxononanoate synthase activity
SMB554_RS21390	COG2801	Transposase and inactivated derivatives
SMB554_RS21440	COG0583	DNA-binding transcription factor activity
SMB554_RS21445	COG0667	Aldo Keto reductase
SMB554_RS21465	COG0583	DNA-binding transcription factor activity
SMB554_RS21645	COG3005	denitrification pathway
SMB554_RS21670	COG4459	periplasmic nitrate reductase
SMB554_RS21680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMB554_RS21705	COG2151	metal-sulfur cluster biosynthetic enzyme
SMB554_RS21735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMB554_RS21745	COG0714	Associated with various cellular activities
SMB554_RS21750	COG3256	nitric oxide reductase
SMB554_RS21765	COG1845	cytochrome c oxidase, subunit III
SMB554_RS21790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMB554_RS21800	COG0826	peptidase U32
SMB554_RS21805	COG0826	peptidase U32
SMB554_RS21830	COG1309	transcriptional regulator
SMB554_RS21835	COG2814	Major facilitator Superfamily
SMB554_RS21840	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SMB554_RS21845	COG2948	multi-organism process
SMB554_RS21850	COG3504	Conjugal transfer protein
SMB554_RS21855	COG3736	Type IV secretory pathway, component VirB8
SMB554_RS21865	COG3704	protein secretion by the type IV secretion system
SMB554_RS21880	COG3451	type IV secretory pathway VirB4
SMB554_RS21885	COG3702	type iv secretory pathway
SMB554_RS21890	COG3838	Conjugal transfer protein Trbc
SMB554_RS21925	COG0477	Major facilitator Superfamily
SMB554_RS21930	COG0024	Methionine aminopeptidase
SMB554_RS21940	COG5564	TIM-barrel signal transduction protein
SMB554_RS21960	COG1175	transmembrane transport
SMB554_RS21975	COG3842	ATPase activity
SMB554_RS21980	COG3842	ATPase activity
SMB554_RS21985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMB554_RS21995	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS22000	COG1082	Xylose isomerase domain protein TIM barrel
SMB554_RS22005	COG1082	Xylose isomerase domain protein TIM barrel
SMB554_RS22025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMB554_RS22045	COG0395	ABC-type sugar transport system, permease component
SMB554_RS22050	COG1175	transmembrane transport
SMB554_RS22070	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS22085	COG4608	Belongs to the ABC transporter superfamily
SMB554_RS22090	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS22095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS22100	COG0601	transmembrane transport
SMB554_RS22105	COG0747	negative chemotaxis
SMB554_RS22110	COG0154	amidase activity
SMB554_RS22120	COG0747	negative chemotaxis
SMB554_RS22145	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMB554_RS22150	COG2086	electron transfer activity
SMB554_RS22170	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS22185	COG1024	Enoyl-CoA hydratase
SMB554_RS22195	COG0656	L-ascorbic acid biosynthetic process
SMB554_RS22240	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS22250	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS22255	COG1129	ABC transporter
SMB554_RS22260	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS22270	COG1309	transcriptional regulator
SMB554_RS22275	COG1063	alcohol dehydrogenase
SMB554_RS22285	COG4172	Belongs to the ABC transporter superfamily
SMB554_RS22290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS22295	COG0601	transmembrane transport
SMB554_RS22300	COG0747	negative chemotaxis
SMB554_RS22310	COG2186	Transcriptional regulator
SMB554_RS22320	COG0477	Major facilitator Superfamily
SMB554_RS22330	COG0183	Belongs to the thiolase family
SMB554_RS22360	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS22385	COG1335	isochorismatase
SMB554_RS22390	COG0006	proline dipeptidase activity
SMB554_RS22400	COG5598	trimethylamine methyltransferase
SMB554_RS22450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMB554_RS22455	COG0625	glutathione transferase activity
SMB554_RS22475	COG1802	Transcriptional regulator
SMB554_RS22485	COG3845	ABC transporter
SMB554_RS22490	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS22495	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS22565	COG0651	ATP synthesis coupled electron transport
SMB554_RS22575	COG0651	ATP synthesis coupled electron transport
SMB554_RS22585	COG0839	Belongs to the complex I subunit 6 family
SMB554_RS22590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMB554_RS22595	COG5001	Diguanylate cyclase
SMB554_RS22615	COG0840	transmembrane signaling receptor activity
SMB554_RS22655	COG0489	protein tyrosine kinase activity
SMB554_RS22680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMB554_RS22680	COG3264	Mechanosensitive ion channel
SMB554_RS22720	COG3177	Filamentation induced by cAMP protein fic
SMB554_RS22725	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS22725	COG1672	PFAM Archaeal ATPase
SMB554_RS22730	COG0723	plastoquinol--plastocyanin reductase activity
SMB554_RS22750	COG4651	solute:proton antiporter activity
SMB554_RS22750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMB554_RS22760	COG1902	pentaerythritol trinitrate reductase activity
SMB554_RS22785	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS22795	COG0583	DNA-binding transcription factor activity
SMB554_RS22830	COG0444	Belongs to the ABC transporter superfamily
SMB554_RS22835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS22905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SMB554_RS22910	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMB554_RS22915	COG0471	metal ion transport
SMB554_RS22915	COG0490	domain, Protein
SMB554_RS22945	COG3328	transposase activity
SMB554_RS22960	COG3119	arylsulfatase activity
SMB554_RS22965	COG4191	Histidine kinase
SMB554_RS23040	COG2252	PERMEase
SMB554_RS23050	COG0583	DNA-binding transcription factor activity
SMB554_RS23060	COG1335	isochorismatase
SMB554_RS23070	COG1309	transcriptional regulator
SMB554_RS23105	COG1484	DNA-dependent DNA replication
SMB554_RS23110	COG4584	PFAM Integrase catalytic
SMB554_RS23125	COG0583	DNA-binding transcription factor activity
SMB554_RS23150	COG1120	ATPase activity
SMB554_RS23155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMB554_RS23160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMB554_RS23190	COG1177	transmembrane transport
SMB554_RS23195	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMB554_RS23200	COG3842	ATPase activity
SMB554_RS23210	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS23215	COG1802	Transcriptional regulator
SMB554_RS23225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMB554_RS23285	COG0583	DNA-binding transcription factor activity
SMB554_RS23290	COG1672	PFAM Archaeal ATPase
SMB554_RS23290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS23360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMB554_RS23365	COG2814	Major facilitator Superfamily
SMB554_RS23375	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SMB554_RS23385	COG1335	isochorismatase
SMB554_RS23395	COG4977	sequence-specific DNA binding
SMB554_RS23395	COG1917	Cupin 2, conserved barrel domain protein
SMB554_RS23400	COG2207	Transcriptional regulator
SMB554_RS23445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMB554_RS23460	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS23465	COG0473	3-isopropylmalate dehydrogenase activity
SMB554_RS23475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS23485	COG0454	-acetyltransferase
SMB554_RS23505	COG0601	transmembrane transport
SMB554_RS23510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS23520	COG1522	sequence-specific DNA binding
SMB554_RS23535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMB554_RS23545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMB554_RS23550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMB554_RS23555	COG1120	ATPase activity
SMB554_RS23585	COG0492	ferredoxin-NADP+ reductase activity
SMB554_RS23590	COG0583	DNA-binding transcription factor activity
SMB554_RS23615	COG1404	Belongs to the peptidase S8 family
SMB554_RS23635	COG0583	DNA-binding transcription factor activity
SMB554_RS23660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS23665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMB554_RS23670	COG2080	2 iron, 2 sulfur cluster binding
SMB554_RS23680	COG3328	transposase activity
SMB554_RS23715	COG0583	DNA-binding transcription factor activity
SMB554_RS23795	COG2814	Major facilitator Superfamily
SMB554_RS23810	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SMB554_RS23820	COG0583	DNA-binding transcription factor activity
SMB554_RS23850	COG0235	Class ii aldolase
SMB554_RS23860	COG0583	DNA-binding transcription factor activity
SMB554_RS23870	COG0583	DNA-binding transcription factor activity
SMB554_RS23885	COG1309	transcriptional regulator
SMB554_RS23890	COG4221	oxidoreductase activity
SMB554_RS23895	COG1902	pentaerythritol trinitrate reductase activity
SMB554_RS23900	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS23910	COG0604	alcohol dehydrogenase
SMB554_RS23910	COG3321	synthase
SMB554_RS23930	COG3609	addiction module antidote protein, CC2985 family
SMB554_RS23975	COG1942	4-Oxalocrotonate Tautomerase
SMB554_RS24000	COG4191	Histidine kinase
SMB554_RS24005	COG4566	intracellular signal transduction
SMB554_RS24010	COG2204	response regulator
SMB554_RS24015	COG2207	Transcriptional regulator
SMB554_RS24025	COG0673	inositol 2-dehydrogenase activity
SMB554_RS24065	COG1902	pentaerythritol trinitrate reductase activity
SMB554_RS24065	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMB554_RS24080	COG2222	sugar isomerase
SMB554_RS24085	COG1609	Transcriptional regulator
SMB554_RS24090	COG2423	ornithine cyclodeaminase activity
SMB554_RS24095	COG1126	abc transporter atp-binding protein
SMB554_RS24100	COG0765	amino acid transport
SMB554_RS24225	COG1063	alcohol dehydrogenase
SMB554_RS24250	COG3842	ATPase activity
SMB554_RS24255	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS24265	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS24275	COG0596	Alpha beta hydrolase
SMB554_RS24285	COG0596	Alpha beta hydrolase
SMB554_RS24295	COG4566	intracellular signal transduction
SMB554_RS24300	COG4191	Histidine kinase
SMB554_RS24320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMB554_RS24325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMB554_RS24335	COG0596	Alpha beta hydrolase
SMB554_RS24340	COG4191	Histidine kinase
SMB554_RS24350	COG4566	intracellular signal transduction
SMB554_RS24385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMB554_RS24400	COG1309	transcriptional regulator
SMB554_RS24415	COG0492	ferredoxin-NADP+ reductase activity
SMB554_RS24420	COG0583	DNA-binding transcription factor activity
SMB554_RS24450	COG1917	Cupin 2, conserved barrel domain protein
SMB554_RS24455	COG0596	Alpha beta hydrolase
SMB554_RS24480	COG3547	Transposase (IS116 IS110 IS902 family)
SMB554_RS24490	COG3831	ATPase activity
SMB554_RS24525	COG3505	Type IV secretory pathway VirD4
SMB554_RS24530	COG0745	RESPONSE REGULATOR receiver
SMB554_RS24615	COG3328	transposase activity
SMB554_RS24625	COG2226	methyltransferase
SMB554_RS24630	COG2124	cytochrome p450
SMB554_RS24655	COG1115	amino acid carrier protein
SMB554_RS24680	COG1278	Cold shock
SMB554_RS24765	COG4584	PFAM Integrase catalytic
SMB554_RS24770	COG1484	DNA-dependent DNA replication
SMB554_RS24815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMB554_RS24830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMB554_RS24850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMB554_RS24860	COG1396	sequence-specific DNA binding
SMB554_RS24875	COG5001	Diguanylate cyclase
SMB554_RS24905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMB554_RS24910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMB554_RS24910	COG2010	Cytochrome c
SMB554_RS24915	COG2010	Cytochrome c
SMB554_RS24920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMB554_RS25145	COG0583	DNA-binding transcription factor activity
SMB554_RS25150	COG0251	oxidation-reduction process
SMB554_RS25155	COG1902	pentaerythritol trinitrate reductase activity
SMB554_RS25165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMB554_RS25195	COG3706	GGDEF domain
SMB554_RS25195	COG4251	negative regulation of phosphorylation
SMB554_RS25195	COG5001	Diguanylate cyclase
SMB554_RS25195	COG2203	Gaf domain
SMB554_RS25215	COG0395	ABC-type sugar transport system, permease component
SMB554_RS25260	COG2205	protein histidine kinase activity
SMB554_RS25295	COG4221	oxidoreductase activity
SMB554_RS25315	COG2080	2 iron, 2 sulfur cluster binding
SMB554_RS25320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMB554_RS25325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS25345	COG0730	response to heat
SMB554_RS25360	COG3845	ABC transporter
SMB554_RS25365	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS25370	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS25375	COG0402	S-adenosylhomocysteine deaminase activity
SMB554_RS25405	COG1309	transcriptional regulator
SMB554_RS25415	COG0488	(ABC) transporter
SMB554_RS25425	COG1764	response to oxidative stress
SMB554_RS25430	COG1414	Transcriptional regulator
SMB554_RS25435	COG1475	DNA binding
SMB554_RS25440	COG1192	Involved in chromosome partitioning
SMB554_RS25470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMB554_RS25480	COG0625	glutathione transferase activity
SMB554_RS25490	COG0753	catalase activity
SMB554_RS25495	COG1793	dna ligase
SMB554_RS25500	COG0583	DNA-binding transcription factor activity
SMB554_RS25525	COG1609	Transcriptional regulator
SMB554_RS25530	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS25535	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS25540	COG1129	ABC transporter
SMB554_RS25555	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMB554_RS25560	COG0022	dehydrogenase e1 component
SMB554_RS25565	COG1522	sequence-specific DNA binding
SMB554_RS25620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMB554_RS25635	COG1309	transcriptional regulator
SMB554_RS25640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMB554_RS25645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS25650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS25655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMB554_RS25670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMB554_RS25675	COG0697	spore germination
SMB554_RS25695	COG1414	Transcriptional regulator
SMB554_RS25700	COG1475	DNA binding
SMB554_RS25705	COG1192	Involved in chromosome partitioning
SMB554_RS25715	COG2188	Transcriptional regulator
SMB554_RS25720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMB554_RS25740	COG2358	TRAP transporter, solute receptor (TAXI family
SMB554_RS25760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMB554_RS25765	COG1120	ATPase activity
SMB554_RS25790	COG3609	addiction module antidote protein, CC2985 family
SMB554_RS25820	COG3360	Dodecin
SMB554_RS25825	COG1115	amino acid carrier protein
SMB554_RS25830	COG0659	secondary active sulfate transmembrane transporter activity
SMB554_RS25840	COG2814	Major facilitator Superfamily
SMB554_RS25850	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS25865	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS25870	COG4585	Histidine kinase
SMB554_RS25875	COG2197	response regulator
SMB554_RS25950	COG3685	Protein conserved in bacteria
SMB554_RS25960	COG0392	lysyltransferase activity
SMB554_RS25970	COG0028	Belongs to the TPP enzyme family
SMB554_RS26000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMB554_RS26005	COG0579	oxidoreductase
SMB554_RS26010	COG3284	Transcriptional regulator
SMB554_RS26025	COG1802	Transcriptional regulator
SMB554_RS26040	COG0747	negative chemotaxis
SMB554_RS26045	COG0601	transmembrane transport
SMB554_RS26050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS26065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMB554_RS26070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMB554_RS26085	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS26120	COG0626	cystathionine gamma-synthase activity
SMB554_RS26125	COG0583	DNA-binding transcription factor activity
SMB554_RS26130	COG3845	ABC transporter
SMB554_RS26135	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS26140	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS26160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMB554_RS26170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS26170	COG2080	2 iron, 2 sulfur cluster binding
SMB554_RS26175	COG0523	cobalamin synthesis protein
SMB554_RS26180	COG2233	PERMEase
SMB554_RS26185	COG0163	prenyltransferase activity
SMB554_RS26210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMB554_RS26220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS26225	COG0601	transmembrane transport
SMB554_RS26230	COG0747	negative chemotaxis
SMB554_RS26240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMB554_RS26245	COG1454	alcohol dehydrogenase
SMB554_RS26255	COG3395	kinase activity
SMB554_RS26280	COG1609	Transcriptional regulator
SMB554_RS26285	COG1178	ABC-type Fe3 transport system permease component
SMB554_RS26290	COG3842	ATPase activity
SMB554_RS26365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SMB554_RS26370	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMB554_RS26430	COG1116	anion transmembrane transporter activity
SMB554_RS26435	COG1131	(ABC) transporter
SMB554_RS26440	COG0842	Transport permease protein
SMB554_RS26445	COG3791	Glutathione-dependent formaldehyde-activating
SMB554_RS26465	COG4451	ribulose bisphosphate carboxylase, small
SMB554_RS26470	COG1850	ribulose-bisphosphate carboxylase activity
SMB554_RS26475	COG0191	fructose-bisphosphate aldolase activity
SMB554_RS26480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMB554_RS26485	COG3954	Phosphoribulokinase
SMB554_RS26490	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMB554_RS26495	COG0583	DNA-binding transcription factor activity
SMB554_RS26505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMB554_RS26510	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SMB554_RS26515	COG0535	radical SAM domain protein
SMB554_RS26520	COG0535	radical SAM domain protein
SMB554_RS26530	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS26535	COG0583	DNA-binding transcription factor activity
SMB554_RS26545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMB554_RS26545	COG0785	Cytochrome C biogenesis protein
SMB554_RS26550	COG0300	oxidoreductase activity
SMB554_RS26580	COG0596	Alpha beta hydrolase
SMB554_RS26585	COG0596	Alpha beta hydrolase
SMB554_RS26630	COG1609	Transcriptional regulator
SMB554_RS26635	COG2182	Extracellular solute-binding protein
SMB554_RS26640	COG1175	transmembrane transport
SMB554_RS26645	COG0395	ABC-type sugar transport system, permease component
SMB554_RS26655	COG3842	ATPase activity
SMB554_RS26675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS26700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS26710	COG1063	alcohol dehydrogenase
SMB554_RS26715	COG0673	inositol 2-dehydrogenase activity
SMB554_RS26725	COG1260	myo-inositol-1-phosphate synthase
SMB554_RS26765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS26775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMB554_RS26785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SMB554_RS26805	COG0765	amino acid transport
SMB554_RS26815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS26820	COG3938	Belongs to the proline racemase family
SMB554_RS26830	COG3938	Belongs to the proline racemase family
SMB554_RS26835	COG1765	OsmC-like protein
SMB554_RS26840	COG2814	Major facilitator Superfamily
SMB554_RS26860	COG3246	L-lysine catabolic process to acetate
SMB554_RS26870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMB554_RS26885	COG2072	flavoprotein involved in K transport
SMB554_RS26890	COG3842	ATPase activity
SMB554_RS26895	COG1177	transmembrane transport
SMB554_RS26925	COG0402	S-adenosylhomocysteine deaminase activity
SMB554_RS26930	COG2233	PERMEase
SMB554_RS26935	COG1609	Transcriptional regulator
SMB554_RS26945	COG2358	TRAP transporter, solute receptor (TAXI family
SMB554_RS26960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS26965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMB554_RS26965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS26970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS26975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMB554_RS26980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMB554_RS26990	COG2133	pyrroloquinoline quinone binding
SMB554_RS27010	COG2376	Dihydroxyacetone kinase
SMB554_RS27015	COG1461	Dihydroxyacetone kinase
SMB554_RS27020	COG2376	Dihydroxyacetone kinase
SMB554_RS27030	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS27035	COG1129	ABC transporter
SMB554_RS27040	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS27055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS27060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS27075	COG1609	Transcriptional regulator
SMB554_RS27080	COG1653	transport
SMB554_RS27095	COG3842	ATPase activity
SMB554_RS27105	COG0673	inositol 2-dehydrogenase activity
SMB554_RS27150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMB554_RS27165	COG1309	transcriptional regulator
SMB554_RS27195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS27195	COG2010	Cytochrome c
SMB554_RS27205	COG2207	Transcriptional regulator
SMB554_RS27225	COG0287	Prephenate dehydrogenase
SMB554_RS27245	COG1129	ABC transporter
SMB554_RS27250	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS27255	COG0673	inositol 2-dehydrogenase activity
SMB554_RS27270	COG0784	Response regulator, receiver
SMB554_RS27270	COG2205	protein histidine kinase activity
SMB554_RS27305	COG3842	ATPase activity
SMB554_RS27315	COG1840	ABC-type Fe3 transport system, periplasmic component
SMB554_RS27320	COG1609	Transcriptional regulator
SMB554_RS27325	COG1309	transcriptional regulator
SMB554_RS27340	COG1136	(ABC) transporter
SMB554_RS27345	COG0698	ribose 5-phosphate isomerase
SMB554_RS27350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS27360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS27365	COG2186	Transcriptional regulator
SMB554_RS27385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMB554_RS27390	COG3842	ATPase activity
SMB554_RS27395	COG1177	transmembrane transport
SMB554_RS27400	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMB554_RS27430	COG0604	alcohol dehydrogenase
SMB554_RS27455	COG2186	Transcriptional regulator
SMB554_RS27460	COG1850	ribulose-bisphosphate carboxylase activity
SMB554_RS27470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS27475	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMB554_RS27480	COG2080	2 iron, 2 sulfur cluster binding
SMB554_RS27510	COG2080	2 iron, 2 sulfur cluster binding
SMB554_RS27515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS27515	COG2010	Cytochrome c
SMB554_RS27525	COG0145	ligase activity
SMB554_RS27530	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SMB554_RS27535	COG4647	ligase activity
SMB554_RS27575	COG1653	transport
SMB554_RS27580	COG1175	transmembrane transport
SMB554_RS27585	COG0395	ABC-type sugar transport system, permease component
SMB554_RS27590	COG3842	ATPase activity
SMB554_RS27595	COG0625	glutathione transferase activity
SMB554_RS27600	COG1063	alcohol dehydrogenase
SMB554_RS27605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMB554_RS27610	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS27615	COG1522	sequence-specific DNA binding
SMB554_RS27620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMB554_RS27625	COG1126	abc transporter atp-binding protein
SMB554_RS27635	COG0765	amino acid transport
SMB554_RS27640	COG0765	amino acid transport
SMB554_RS27645	COG3473	Maleate cis-trans isomerase
SMB554_RS27650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMB554_RS27655	COG2423	ornithine cyclodeaminase activity
SMB554_RS27660	COG0006	proline dipeptidase activity
SMB554_RS27665	COG3608	succinylglutamate desuccinylase aspartoacylase
SMB554_RS27680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS27690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS27695	COG1063	alcohol dehydrogenase
SMB554_RS27700	COG1312	Catalyzes the dehydration of D-mannonate
SMB554_RS27705	COG3300	MHYT domain
SMB554_RS27705	COG5001	Diguanylate cyclase
SMB554_RS27745	COG1309	transcriptional regulator
SMB554_RS27750	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS27800	COG1363	Peptidase, m42
SMB554_RS27805	COG4585	Histidine kinase
SMB554_RS27835	COG2192	nodulation
SMB554_RS27860	COG0747	negative chemotaxis
SMB554_RS27865	COG0601	transmembrane transport
SMB554_RS27875	COG4608	Belongs to the ABC transporter superfamily
SMB554_RS27880	COG2188	Transcriptional regulator
SMB554_RS27885	COG0367	asparagine synthase
SMB554_RS27905	COG1129	ABC transporter
SMB554_RS27910	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS27930	COG0235	Class ii aldolase
SMB554_RS27950	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS27955	COG0583	DNA-binding transcription factor activity
SMB554_RS27975	COG1070	Carbohydrate kinase
SMB554_RS27985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMB554_RS27990	COG0667	Aldo Keto reductase
SMB554_RS28000	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS28005	COG1129	ABC transporter
SMB554_RS28025	COG1129	ABC transporter
SMB554_RS28035	COG2186	Transcriptional regulator
SMB554_RS28040	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS28045	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS28050	COG2124	cytochrome p450
SMB554_RS28060	COG0300	oxidoreductase activity
SMB554_RS28090	COG2201	protein-glutamate methylesterase activity
SMB554_RS28110	COG3179	chitinase
SMB554_RS28160	COG3706	GGDEF domain
SMB554_RS28170	COG1309	transcriptional regulator
SMB554_RS28190	COG3220	belongs to the UPF0276 family
SMB554_RS28235	COG1609	Transcriptional regulator
SMB554_RS28240	COG2182	Extracellular solute-binding protein
SMB554_RS28380	COG2246	polysaccharide biosynthetic process
SMB554_RS28385	COG0463	Glycosyl transferase, family 2
SMB554_RS28390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS28405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMB554_RS28425	COG1484	DNA-dependent DNA replication
SMB554_RS28430	COG4584	PFAM Integrase catalytic
SMB554_RS28445	COG3328	transposase activity
SMB554_RS28480	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS28485	COG2197	response regulator
SMB554_RS28525	COG3328	transposase activity
SMB554_RS28530	COG2832	Protein of unknown function (DUF454)
SMB554_RS28590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SMB554_RS28600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMB554_RS28600	COG0517	IMP dehydrogenase activity
SMB554_RS28620	COG1132	(ABC) transporter
SMB554_RS28635	COG1609	Transcriptional regulator
SMB554_RS28655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMB554_RS28695	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS28730	COG3347	Dehydrogenase
SMB554_RS28730	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS28745	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS28855	COG0601	transmembrane transport
SMB554_RS28860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS28870	COG2843	Capsule synthesis protein
SMB554_RS28875	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMB554_RS28880	COG1793	dna ligase
SMB554_RS28880	COG3285	dna ligase
SMB554_RS28915	COG1525	nuclease
SMB554_RS28965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMB554_RS28990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SMB554_RS29015	COG0165	Argininosuccinate lyase
SMB554_RS29025	COG1126	abc transporter atp-binding protein
SMB554_RS29035	COG2079	MmgE PrpD family protein
SMB554_RS29055	COG1414	Transcriptional regulator
SMB554_RS29070	COG0395	ABC-type sugar transport system, permease component
SMB554_RS29075	COG3842	ATPase activity
SMB554_RS29080	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS29085	COG3254	rhamnose metabolic process
SMB554_RS29100	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS29105	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMB554_RS29110	COG4948	Mandelate Racemase Muconate Lactonizing
SMB554_RS29115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMB554_RS29120	COG3707	response regulator
SMB554_RS29130	COG1396	sequence-specific DNA binding
SMB554_RS29135	COG3265	gluconokinase activity
SMB554_RS29145	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS29150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMB554_RS29185	COG0277	FAD linked oxidase domain protein
SMB554_RS29190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMB554_RS29195	COG4208	sulfate ABC transporter
SMB554_RS29205	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SMB554_RS29220	COG0765	amino acid transport
SMB554_RS29225	COG0765	amino acid transport
SMB554_RS29235	COG0251	oxidation-reduction process
SMB554_RS29245	COG3842	ATPase activity
SMB554_RS29250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMB554_RS29275	COG1846	Transcriptional regulator
SMB554_RS29275	COG1940	carbohydrate kinase activity
SMB554_RS29280	COG0175	sulfate reduction
SMB554_RS29285	COG2895	sulfate adenylyltransferase (ATP) activity
SMB554_RS29285	COG0529	Catalyzes the synthesis of activated sulfate
SMB554_RS29300	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMB554_RS29305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS29340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMB554_RS29370	COG0297	glycogen (starch) synthase activity
SMB554_RS29385	COG1596	polysaccharide export
SMB554_RS29390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMB554_RS29400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMB554_RS29410	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS29415	COG0668	transmembrane transport
SMB554_RS29460	COG0747	negative chemotaxis
SMB554_RS29465	COG0601	transmembrane transport
SMB554_RS29470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS29495	COG1132	(ABC) transporter
SMB554_RS29500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMB554_RS29500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMB554_RS29510	COG1609	Transcriptional regulator
SMB554_RS29520	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMB554_RS29525	COG1177	transmembrane transport
SMB554_RS29530	COG3842	ATPase activity
SMB554_RS29540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SMB554_RS29545	COG1473	amidohydrolase
SMB554_RS29550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMB554_RS29555	COG2252	PERMEase
SMB554_RS29565	COG4266	Belongs to the allantoicase family
SMB554_RS29570	COG3648	Uricase
SMB554_RS29570	COG3195	allantoin biosynthetic process
SMB554_RS29575	COG2351	hydroxyisourate hydrolase activity
SMB554_RS29585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS29595	COG1733	regulation of RNA biosynthetic process
SMB554_RS29615	COG0402	S-adenosylhomocysteine deaminase activity
SMB554_RS29620	COG0071	Belongs to the small heat shock protein (HSP20) family
SMB554_RS29625	COG0071	Belongs to the small heat shock protein (HSP20) family
SMB554_RS29635	COG4953	penicillin-binding protein 1C
SMB554_RS29645	COG1349	DNA-binding transcription factor activity
SMB554_RS29650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMB554_RS29655	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS29675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMB554_RS29680	COG1732	Glycine betaine
SMB554_RS29685	COG1174	glycine betaine transport
SMB554_RS29690	COG1125	glycine betaine transport
SMB554_RS29695	COG1174	glycine betaine transport
SMB554_RS29700	COG0673	inositol 2-dehydrogenase activity
SMB554_RS29710	COG0395	ABC-type sugar transport system, permease component
SMB554_RS29720	COG3842	ATPase activity
SMB554_RS29745	COG0251	oxidation-reduction process
SMB554_RS29750	COG1737	Transcriptional regulator
SMB554_RS29775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMB554_RS29785	COG2986	histidine ammonia-lyase
SMB554_RS29790	COG1228	amidohydrolase
SMB554_RS29805	COG2814	Major facilitator Superfamily
SMB554_RS29810	COG0640	Transcriptional regulator
SMB554_RS29815	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SMB554_RS29820	COG3454	Phosphonate metabolism
SMB554_RS29825	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SMB554_RS29835	COG3639	organic phosphonate transmembrane transporter activity
SMB554_RS29840	COG3639	organic phosphonate transmembrane transporter activity
SMB554_RS29850	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SMB554_RS29870	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS29880	COG0326	Molecular chaperone. Has ATPase activity
SMB554_RS29885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMB554_RS29890	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS29895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMB554_RS29905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMB554_RS29905	COG2755	lipolytic protein G-D-S-L family
SMB554_RS29910	COG1216	Glycosyl transferase, family 2
SMB554_RS29920	COG1132	(ABC) transporter
SMB554_RS29930	COG4166	transmembrane transport
SMB554_RS29935	COG0601	transmembrane transport
SMB554_RS29940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS29945	COG4172	Belongs to the ABC transporter superfamily
SMB554_RS29960	COG0346	lactoylglutathione lyase activity
SMB554_RS29975	COG0842	Transport permease protein
SMB554_RS29980	COG0842	Transport permease protein
SMB554_RS29985	COG1131	(ABC) transporter
SMB554_RS29990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS30000	COG2205	protein histidine kinase activity
SMB554_RS30005	COG0745	RESPONSE REGULATOR receiver
SMB554_RS30010	COG2194	sulfuric ester hydrolase activity
SMB554_RS30025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMB554_RS30030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMB554_RS30060	COG0297	glycogen (starch) synthase activity
SMB554_RS30080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS30090	COG1846	Transcriptional regulator
SMB554_RS30130	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SMB554_RS30140	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMB554_RS30155	COG3237	CsbD-like
SMB554_RS30180	COG0628	permease
SMB554_RS30190	COG2080	2 iron, 2 sulfur cluster binding
SMB554_RS30195	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMB554_RS30200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS30210	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS30215	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS30220	COG1129	ABC transporter
SMB554_RS30225	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS30230	COG1609	Transcriptional regulator
SMB554_RS30240	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS30245	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SMB554_RS30250	COG2186	Transcriptional regulator
SMB554_RS30265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS30270	COG1904	glucuronate isomerase
SMB554_RS30275	COG0673	inositol 2-dehydrogenase activity
SMB554_RS30280	COG1295	ribonuclease BN
SMB554_RS30295	COG0583	DNA-binding transcription factor activity
SMB554_RS30310	COG2323	membrane
SMB554_RS30320	COG1295	ribonuclease BN
SMB554_RS30350	COG2010	Cytochrome c
SMB554_RS30350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMB554_RS30360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMB554_RS30370	COG1609	Transcriptional regulator
SMB554_RS30375	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
SMB554_RS30380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMB554_RS30385	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS30390	COG1129	ABC transporter
SMB554_RS30395	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS30410	COG3485	protocatechuate 3,4-dioxygenase
SMB554_RS30425	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS30430	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SMB554_RS30435	COG2207	Transcriptional regulator
SMB554_RS30440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMB554_RS30445	COG4521	taurine ABC transporter
SMB554_RS30450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SMB554_RS30455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMB554_RS30470	COG0028	Belongs to the TPP enzyme family
SMB554_RS30475	COG2855	membrane
SMB554_RS30485	COG1349	DNA-binding transcription factor activity
SMB554_RS30505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMB554_RS30515	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS30525	COG1840	ABC-type Fe3 transport system, periplasmic component
SMB554_RS30530	COG3842	ATPase activity
SMB554_RS30555	COG3275	phosphorelay sensor kinase activity
SMB554_RS30570	COG2897	thiosulfate sulfurtransferase activity
SMB554_RS30605	COG0475	glutathione-regulated potassium exporter activity
SMB554_RS30605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMB554_RS30610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS30615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMB554_RS30620	COG2080	2 iron, 2 sulfur cluster binding
SMB554_RS30630	COG2205	protein histidine kinase activity
SMB554_RS30660	COG0459	protein refolding
SMB554_RS30665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMB554_RS30670	COG5425	PFAM Usg family protein
SMB554_RS30680	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMB554_RS30680	COG1902	pentaerythritol trinitrate reductase activity
SMB554_RS30700	COG2205	protein histidine kinase activity
SMB554_RS30710	COG0640	Transcriptional regulator
SMB554_RS30730	COG2217	Heavy metal translocating P-type atpase
SMB554_RS30735	COG0789	Transcriptional regulator
SMB554_RS30740	COG1238	metal cluster binding
SMB554_RS30745	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS30770	COG0189	ligase activity
SMB554_RS30775	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS30780	COG1129	ABC transporter
SMB554_RS30785	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS30790	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS30795	COG2186	Transcriptional regulator
SMB554_RS30810	COG1175	transmembrane transport
SMB554_RS30815	COG1653	transport
SMB554_RS30825	COG0673	inositol 2-dehydrogenase activity
SMB554_RS30830	COG1609	Transcriptional regulator
SMB554_RS30850	COG0395	ABC-type sugar transport system, permease component
SMB554_RS30855	COG1175	transmembrane transport
SMB554_RS30860	COG2182	Extracellular solute-binding protein
SMB554_RS30880	COG0750	zinc metalloprotease
SMB554_RS30890	COG0793	Belongs to the peptidase S41A family
SMB554_RS30890	COG3409	Peptidoglycan-binding domain 1 protein
SMB554_RS30895	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS30900	COG1129	ABC transporter
SMB554_RS30910	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SMB554_RS30910	COG2273	Hydrolase Family 16
SMB554_RS30915	COG2202	Pas domain
SMB554_RS30915	COG3920	Histidine kinase
SMB554_RS30920	COG0784	Response regulator, receiver
SMB554_RS30945	COG0602	queuosine metabolic process
SMB554_RS30950	COG0720	synthase
SMB554_RS30955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMB554_RS30960	COG5265	(ABC) transporter
SMB554_RS30965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMB554_RS30970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMB554_RS30975	COG3307	-O-antigen
SMB554_RS30980	COG1596	polysaccharide export
SMB554_RS30985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMB554_RS30995	COG1215	transferase activity, transferring glycosyl groups
SMB554_RS31000	COG2327	Polysaccharide pyruvyl transferase
SMB554_RS31005	COG0463	Glycosyl transferase, family 2
SMB554_RS31010	COG2244	polysaccharide biosynthetic process
SMB554_RS31020	COG1525	nuclease
SMB554_RS31035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMB554_RS31040	COG2273	Hydrolase Family 16
SMB554_RS31045	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS31050	COG1215	transferase activity, transferring glycosyl groups
SMB554_RS31055	COG1215	transferase activity, transferring glycosyl groups
SMB554_RS31060	COG1215	transferase activity, transferring glycosyl groups
SMB554_RS31065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMB554_RS31070	COG3206	protein involved in exopolysaccharide biosynthesis
SMB554_RS31070	COG0489	protein tyrosine kinase activity
SMB554_RS31080	COG0351	phosphomethylpyrimidine kinase
SMB554_RS31095	COG0450	alkyl hydroperoxide reductase
SMB554_RS31110	COG1609	Transcriptional regulator
SMB554_RS31120	COG0395	ABC-type sugar transport system, permease component
SMB554_RS31125	COG1175	transmembrane transport
SMB554_RS31135	COG3842	ATPase activity
SMB554_RS31140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMB554_RS31150	COG0765	amino acid transport
SMB554_RS31160	COG1609	Transcriptional regulator
SMB554_RS31170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS31180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS31195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMB554_RS31205	COG0243	molybdopterin cofactor binding
SMB554_RS31210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMB554_RS31210	COG1648	precorrin-2 dehydrogenase activity
SMB554_RS31215	COG1051	belongs to the nudix hydrolase family
SMB554_RS31225	COG0330	HflC and HflK could
SMB554_RS31255	COG3328	transposase activity
SMB554_RS31260	COG1959	2 iron, 2 sulfur cluster binding
SMB554_RS31265	COG1160	GTP binding
SMB554_RS31285	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
SMB554_RS31290	COG0477	Major facilitator Superfamily
SMB554_RS31300	COG0024	Methionine aminopeptidase
SMB554_RS31335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMB554_RS31340	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS31355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMB554_RS31365	COG0583	DNA-binding transcription factor activity
SMB554_RS31375	COG0402	S-adenosylhomocysteine deaminase activity
SMB554_RS31385	COG2390	Transcriptional regulator
SMB554_RS31390	COG1069	ribulokinase activity
SMB554_RS31395	COG1063	alcohol dehydrogenase
SMB554_RS31400	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS31405	COG1129	ABC transporter
SMB554_RS31410	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS31415	COG2140	Oxalate decarboxylase
SMB554_RS31460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMB554_RS31470	COG4191	Histidine kinase
SMB554_RS31475	COG4566	intracellular signal transduction
SMB554_RS31480	COG4566	intracellular signal transduction
SMB554_RS31485	COG0583	DNA-binding transcription factor activity
SMB554_RS31490	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS31495	COG2351	hydroxyisourate hydrolase activity
SMB554_RS31500	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
SMB554_RS31505	COG3648	Uricase
SMB554_RS31505	COG3195	allantoin biosynthetic process
SMB554_RS31525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMB554_RS31525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMB554_RS31535	COG0513	Belongs to the DEAD box helicase family
SMB554_RS31545	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMB554_RS31575	COG2308	Evidence 4 Homologs of previously reported genes of
SMB554_RS31585	COG1305	Transglutaminase-like
SMB554_RS31595	COG0129	dihydroxy-acid dehydratase activity
SMB554_RS31600	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS31610	COG4214	carbohydrate transport
SMB554_RS31620	COG4213	ABC transporter substrate-binding protein
SMB554_RS31645	COG0673	inositol 2-dehydrogenase activity
SMB554_RS31665	COG4213	ABC transporter substrate-binding protein
SMB554_RS31670	COG4214	carbohydrate transport
SMB554_RS31675	COG1129	ABC transporter
SMB554_RS31690	COG3547	Transposase (IS116 IS110 IS902 family)
SMB554_RS31760	COG1335	isochorismatase
SMB554_RS31770	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SMB554_RS31795	COG3189	MarR family transcriptional regulator
SMB554_RS31800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMB554_RS31850	COG1129	ABC transporter
SMB554_RS31855	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS31885	COG1120	ATPase activity
SMB554_RS31890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMB554_RS31900	COG2226	methyltransferase
SMB554_RS31910	COG0583	DNA-binding transcription factor activity
SMB554_RS31920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SMB554_RS31925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMB554_RS31930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SMB554_RS31985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMB554_RS31990	COG1573	uracil-dna glycosylase
SMB554_RS32045	COG3842	ATPase activity
SMB554_RS32050	COG1653	transport
SMB554_RS32055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMB554_RS32055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMB554_RS32060	COG1486	melibiose metabolic process
SMB554_RS32065	COG2188	Transcriptional regulator
SMB554_RS32070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMB554_RS32075	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
SMB554_RS32115	COG0300	oxidoreductase activity
SMB554_RS32135	COG3344	reverse transcriptase
SMB554_RS32155	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SMB554_RS32195	COG0477	Major facilitator Superfamily
SMB554_RS32205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMB554_RS32210	COG1845	cytochrome c oxidase, subunit III
SMB554_RS32215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMB554_RS32220	COG3346	SURF1 family
SMB554_RS32255	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SMB554_RS32285	COG0438	transferase activity, transferring glycosyl groups
SMB554_RS32290	COG2801	Transposase and inactivated derivatives
SMB554_RS32290	COG3415	Transposase
SMB554_RS32310	COG0297	glycogen (starch) synthase activity
SMB554_RS32330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMB554_RS32350	COG2890	protein-(glutamine-N5) methyltransferase activity
SMB554_RS32360	COG1388	LysM domain
SMB554_RS32360	COG1376	ErfK ybiS ycfS ynhG family protein
SMB554_RS32375	COG4585	Histidine kinase
SMB554_RS32380	COG2197	response regulator
SMB554_RS32390	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMB554_RS32395	COG2894	cell division
SMB554_RS32400	COG0850	regulation of cytokinetic process
SMB554_RS32410	COG0656	L-ascorbic acid biosynthetic process
SMB554_RS32420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMB554_RS32425	COG0318	PFAM AMP-dependent synthetase and ligase
SMB554_RS32435	COG0367	asparagine synthase
SMB554_RS32460	COG0667	Aldo Keto reductase
SMB554_RS32470	COG0395	ABC-type sugar transport system, permease component
SMB554_RS32475	COG1175	transmembrane transport
SMB554_RS32485	COG3842	ATPase activity
SMB554_RS32495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMB554_RS32505	COG0235	Class ii aldolase
SMB554_RS32510	COG1609	Transcriptional regulator
SMB554_RS32515	COG2084	Dehydrogenase
SMB554_RS32520	COG3622	Belongs to the hyi family
SMB554_RS32525	COG3395	kinase activity
SMB554_RS32555	COG1879	ABC-type sugar transport system periplasmic component
SMB554_RS32560	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS32585	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
SMB554_RS32595	COG2084	Dehydrogenase
SMB554_RS32600	COG3622	Belongs to the hyi family
SMB554_RS32605	COG3960	tartronate-semialdehyde synthase activity
SMB554_RS32610	COG1414	Transcriptional regulator
SMB554_RS32615	COG0583	DNA-binding transcription factor activity
SMB554_RS32620	COG3257	ureidoglycine aminohydrolase activity
SMB554_RS32630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SMB554_RS32660	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS32665	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS32685	COG4187	Peptidase family M20/M25/M40
SMB554_RS32720	COG0297	glycogen (starch) synthase activity
SMB554_RS32740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMB554_RS32745	COG2094	Belongs to the DNA glycosylase MPG family
SMB554_RS32750	COG2084	Dehydrogenase
SMB554_RS32765	COG1129	ABC transporter
SMB554_RS32770	COG4211	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS32785	COG1609	Transcriptional regulator
SMB554_RS32790	COG1129	ABC transporter
SMB554_RS32795	COG1172	Belongs to the binding-protein-dependent transport system permease family
SMB554_RS32855	COG0174	glutamine synthetase
SMB554_RS32865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMB554_RS32870	COG1215	transferase activity, transferring glycosyl groups
SMB554_RS32875	COG0246	Mannitol dehydrogenase
SMB554_RS32880	COG1028	Short-chain dehydrogenase reductase Sdr
SMB554_RS32890	COG1024	Enoyl-CoA hydratase
SMB554_RS32895	COG1960	acyl-CoA dehydrogenase activity
SMB554_RS32900	COG1396	sequence-specific DNA binding
SMB554_RS32900	COG3800	Transcriptional regulator
SMB554_RS32905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMB554_RS32910	COG4770	biotin carboxylase activity
SMB554_RS32915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMB554_RS32915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMB554_RS32920	COG2188	Transcriptional regulator
SMB554_RS32925	COG3624	Phosphonate C-P lyase system protein PhnG
SMB554_RS32930	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
SMB554_RS32935	COG3626	phosphonate metabolism
SMB554_RS32940	COG3627	carbon phosphorus lyase activity
SMB554_RS32945	COG4107	phosphonate C-P lyase system protein PhnK
SMB554_RS32950	COG4778	phosphonate C-P lyase system protein PhnL
SMB554_RS32960	COG2376	Dihydroxyacetone kinase
SMB554_RS32985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMB554_RS32990	COG1802	Transcriptional regulator
SMB554_RS33000	COG0457	Tetratricopeptide repeat
SMB554_RS33015	COG0411	ABC transporter
SMB554_RS33030	COG0683	leucine binding
SMB554_RS33045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMB554_RS33050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMB554_RS33070	COG3485	protocatechuate 3,4-dioxygenase
SMB554_RS33075	COG3485	protocatechuate 3,4-dioxygenase
SMB554_RS33080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMB554_RS33085	COG2267	carboxylic ester hydrolase activity
SMB554_RS33090	COG0583	DNA-binding transcription factor activity
SMB554_RS33110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMB554_RS33120	COG1414	Transcriptional regulator
SMB554_RS33125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SMB554_RS33130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SMB554_RS33135	COG0183	Belongs to the thiolase family
SMB554_RS33140	COG1254	Belongs to the acylphosphatase family
SMB554_RS33145	COG1595	DNA-templated transcription, initiation
SMB554_RS33175	COG1192	Involved in chromosome partitioning
SMB554_RS33180	COG1475	DNA binding
SMB554_RS33195	COG0411	ABC transporter
SMB554_RS33240	COG1672	PFAM Archaeal ATPase
SMB554_RS33240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SMB554_RS33245	COG0784	Response regulator, receiver
SMB554_RS33245	COG2198	Histidine kinase
SMB554_RS33245	COG5002	protein histidine kinase activity
SMB554_RS33255	COG1301	dicarboxylic acid transport
SMB554_RS33260	COG4191	Histidine kinase
SMB554_RS33265	COG2204	response regulator
SMB554_RS33275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMB554_RS33290	COG2022	thiamine diphosphate biosynthetic process
SMB554_RS33300	COG2814	Major facilitator Superfamily
SMB554_RS33315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SMB554_RS33335	COG0395	ABC-type sugar transport system, permease component
SMB554_RS33340	COG1175	transmembrane transport
SMB554_RS33350	COG1609	Transcriptional regulator
SMB554_RS33360	COG0019	diaminopimelate decarboxylase activity
SMB554_RS33365	COG1024	Enoyl-CoA hydratase
SMB554_RS33365	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMB554_RS33370	COG1024	Enoyl-CoA hydratase
SMB554_RS33375	COG1607	acyl-coa hydrolase
SMB554_RS33380	COG1012	belongs to the aldehyde dehydrogenase family
SMB554_RS33380	COG2030	dehydratase
SMB554_RS33385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMB554_RS33390	COG2151	metal-sulfur cluster biosynthetic enzyme
SMB554_RS33395	COG3396	Phenylacetate-CoA oxygenase
SMB554_RS33400	COG3460	Phenylacetate-CoA oxygenase
SMB554_RS33405	COG3396	Phenylacetate-CoA oxygenase
SMB554_RS33420	COG1486	melibiose metabolic process
SMB554_RS33425	COG4172	Belongs to the ABC transporter superfamily
SMB554_RS33430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMB554_RS33435	COG0601	transmembrane transport
SMB554_RS33440	COG0747	negative chemotaxis
SMB554_RS33445	COG1486	melibiose metabolic process