locus-tag	class	description
I0J99_RS00005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I0J99_RS00010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I0J99_RS00015	COG0424	maF-like protein
I0J99_RS00020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I0J99_RS00025	COG0237	dephospho-CoA kinase activity
I0J99_RS00030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I0J99_RS00035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I0J99_RS00085	COG1802	Transcriptional regulator
I0J99_RS00090	COG2721	sulfolactate sulfo-lyase activity
I0J99_RS00110	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS00115	COG1063	alcohol dehydrogenase
I0J99_RS00135	COG0135	phosphoribosylanthranilate isomerase activity
I0J99_RS00140	COG0133	tryptophan synthase activity
I0J99_RS00145	COG0159	tryptophan synthase activity
I0J99_RS00150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I0J99_RS00165	COG1074	ATP-dependent DNA helicase activity
I0J99_RS00170	COG2887	Belongs to the helicase family. UvrD subfamily
I0J99_RS00175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I0J99_RS00180	COG3178	'Phosphotransferase
I0J99_RS00185	COG2205	protein histidine kinase activity
I0J99_RS00190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I0J99_RS00200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0J99_RS00200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0J99_RS00210	COG2205	protein histidine kinase activity
I0J99_RS00215	COG0745	RESPONSE REGULATOR receiver
I0J99_RS00220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I0J99_RS00230	COG1652	LysM domain
I0J99_RS00240	COG1072	(Pantothenic acid kinase))
I0J99_RS00245	COG0140	phosphoribosyl-ATP diphosphatase activity
I0J99_RS00250	COG0107	imidazoleglycerol-phosphate synthase activity
I0J99_RS00255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I0J99_RS00260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I0J99_RS00270	COG0131	Imidazoleglycerol-phosphate dehydratase
I0J99_RS00275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I0J99_RS00285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I0J99_RS00295	COG2124	cytochrome p450
I0J99_RS00305	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I0J99_RS00320	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I0J99_RS00330	COG1643	Atp-dependent helicase
I0J99_RS00335	COG4136	ATPase activity
I0J99_RS00340	COG4135	transport system, permease component
I0J99_RS00345	COG4134	Bacterial extracellular solute-binding protein
I0J99_RS00400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I0J99_RS00405	COG0626	cystathionine gamma-synthase activity
I0J99_RS00435	COG3119	arylsulfatase activity
I0J99_RS00440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I0J99_RS00450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0J99_RS00450	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0J99_RS00455	COG4311	Sarcosine oxidase, delta subunit
I0J99_RS00460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS00465	COG4977	sequence-specific DNA binding
I0J99_RS00470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I0J99_RS00475	COG2218	PFAM glutamate synthase alpha subunit domain protein
I0J99_RS00480	COG0069	glutamate synthase activity
I0J99_RS00485	COG0174	glutamine synthetase
I0J99_RS00500	COG0531	amino acid
I0J99_RS00530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0J99_RS00555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0J99_RS00565	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I0J99_RS00570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS00580	COG2186	Transcriptional regulator
I0J99_RS00595	COG3842	ATPase activity
I0J99_RS00605	COG0673	inositol 2-dehydrogenase activity
I0J99_RS00610	COG0395	ABC-type sugar transport system, permease component
I0J99_RS00615	COG1175	transmembrane transport
I0J99_RS00620	COG1653	transport
I0J99_RS00625	COG1309	transcriptional regulator
I0J99_RS00630	COG0673	inositol 2-dehydrogenase activity
I0J99_RS00650	COG0673	inositol 2-dehydrogenase activity
I0J99_RS00660	COG3845	ABC transporter
I0J99_RS00665	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS00670	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS00685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I0J99_RS00690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I0J99_RS00695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I0J99_RS00700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I0J99_RS00735	COG4964	Belongs to the GSP D family
I0J99_RS00770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I0J99_RS00780	COG0791	NLP P60 protein
I0J99_RS00790	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS00795	COG4239	(ABC) transporter, permease
I0J99_RS00800	COG4174	ABC transporter (Permease)
I0J99_RS00805	COG4166	transmembrane transport
I0J99_RS00810	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I0J99_RS00815	COG1803	Methylglyoxal synthase
I0J99_RS00820	COG0837	glucose binding
I0J99_RS00825	COG1132	(ABC) transporter
I0J99_RS00830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I0J99_RS00835	COG0588	phosphoglycerate mutase activity
I0J99_RS00840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0J99_RS00855	COG1309	transcriptional regulator
I0J99_RS00865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0J99_RS00885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0J99_RS00885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0J99_RS00895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0J99_RS00915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0J99_RS00920	COG0443	Heat shock 70 kDa protein
I0J99_RS00925	COG0484	heat shock protein binding
I0J99_RS00940	COG0306	phosphate transporter
I0J99_RS00945	COG1392	Phosphate transport regulator
I0J99_RS00950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0J99_RS00970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0J99_RS00975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS00985	COG0673	inositol 2-dehydrogenase activity
I0J99_RS00990	COG0395	ABC-type sugar transport system, permease component
I0J99_RS00995	COG1175	transmembrane transport
I0J99_RS01005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I0J99_RS01010	COG2971	BadF BadG BcrA BcrD
I0J99_RS01015	COG2188	Transcriptional regulator
I0J99_RS01020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I0J99_RS01025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I0J99_RS01030	COG3142	Participates in the control of copper homeostasis
I0J99_RS01035	COG1940	carbohydrate kinase activity
I0J99_RS01050	COG2900	Belongs to the SlyX family
I0J99_RS01055	COG1744	ABC transporter substrate-binding protein PnrA-like
I0J99_RS01060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0J99_RS01085	COG2207	Transcriptional regulator
I0J99_RS01085	COG1917	Cupin 2, conserved barrel domain protein
I0J99_RS01090	COG2814	Major facilitator Superfamily
I0J99_RS01095	COG4771	TonB-dependent receptor
I0J99_RS01105	COG2814	Major facilitator Superfamily
I0J99_RS01125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0J99_RS01130	COG3474	cytochrome
I0J99_RS01135	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I0J99_RS01140	COG0077	Prephenate dehydratase
I0J99_RS01140	COG1605	Chorismate mutase
I0J99_RS01155	COG2816	NAD+ diphosphatase activity
I0J99_RS01170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I0J99_RS01175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I0J99_RS01185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I0J99_RS01190	COG2951	lytic endotransglycosylase activity
I0J99_RS01200	COG2814	Major facilitator Superfamily
I0J99_RS01205	COG0779	Required for maturation of 30S ribosomal subunits
I0J99_RS01210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I0J99_RS01210	COG0195	Participates in both transcription termination and antitermination
I0J99_RS01220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I0J99_RS01225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I0J99_RS01230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I0J99_RS01240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I0J99_RS01245	COG1185	polyribonucleotide nucleotidyltransferase activity
I0J99_RS01255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I0J99_RS01265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0J99_RS01275	COG2860	membrane
I0J99_RS01330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I0J99_RS01335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I0J99_RS01340	COG0539	negative regulation of cytoplasmic translation
I0J99_RS01365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I0J99_RS01370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0J99_RS01400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I0J99_RS01410	COG0481	GTPase activity
I0J99_RS01430	COG3932	Exopolysaccharide synthesis, ExoD
I0J99_RS01435	COG2885	chlorophyll binding
I0J99_RS01440	COG1509	lysine 2,3-aminomutase activity
I0J99_RS01445	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I0J99_RS01450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I0J99_RS01455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0J99_RS01475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I0J99_RS01480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I0J99_RS01485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I0J99_RS01490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I0J99_RS01495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0J99_RS01495	COG0072	phenylalanine-tRNA ligase activity
I0J99_RS01505	COG0667	Aldo Keto reductase
I0J99_RS01530	COG0667	Aldo Keto reductase
I0J99_RS01550	COG1570	exodeoxyribonuclease VII activity
I0J99_RS01555	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0J99_RS01560	COG1846	Transcriptional regulator
I0J99_RS01565	COG0697	spore germination
I0J99_RS01570	COG2309	aminopeptidase activity
I0J99_RS01575	COG0625	glutathione transferase activity
I0J99_RS01590	COG1393	Belongs to the ArsC family
I0J99_RS01595	COG1448	Aminotransferase
I0J99_RS01630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I0J99_RS01630	COG0519	Catalyzes the synthesis of GMP from XMP
I0J99_RS01645	COG1247	-acetyltransferase
I0J99_RS01680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I0J99_RS01695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I0J99_RS01705	COG1968	undecaprenyl-diphosphatase activity
I0J99_RS01715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS01725	COG0284	orotidine-5'-phosphate decarboxylase activity
I0J99_RS01735	COG3963	phosphatidate phosphatase activity
I0J99_RS01745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I0J99_RS01750	COG0792	nuclease activity
I0J99_RS01755	COG0189	ligase activity
I0J99_RS01765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0J99_RS01775	COG1280	lysine exporter protein (LysE YggA)
I0J99_RS01780	COG0697	spore germination
I0J99_RS01785	COG1522	sequence-specific DNA binding
I0J99_RS01790	COG0756	dUTP diphosphatase activity
I0J99_RS01795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I0J99_RS01810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS01820	COG3718	enzyme involved in inositol metabolism
I0J99_RS01855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0J99_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS01880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I0J99_RS01885	COG2226	methyltransferase
I0J99_RS01890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I0J99_RS01895	COG1024	Enoyl-CoA hydratase
I0J99_RS01900	COG0268	Binds directly to 16S ribosomal RNA
I0J99_RS01905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I0J99_RS01910	COG3795	YCII-related domain
I0J99_RS01915	COG4941	Belongs to the sigma-70 factor family
I0J99_RS01930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0J99_RS01935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I0J99_RS01945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I0J99_RS01950	COG1420	regulation of RNA biosynthetic process
I0J99_RS01955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I0J99_RS01960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0J99_RS01965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I0J99_RS01970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I0J99_RS01975	COG1137	ATPase activity
I0J99_RS01980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I0J99_RS01990	COG0616	signal peptide processing
I0J99_RS01995	COG0776	regulation of translation
I0J99_RS02010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I0J99_RS02010	COG0116	Belongs to the methyltransferase superfamily
I0J99_RS02015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0J99_RS02020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I0J99_RS02025	COG0784	Response regulator, receiver
I0J99_RS02025	COG2205	protein histidine kinase activity
I0J99_RS02025	COG5002	protein histidine kinase activity
I0J99_RS02035	COG0280	phosphate acetyltransferase
I0J99_RS02035	COG0281	malic enzyme
I0J99_RS02040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I0J99_RS02045	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I0J99_RS02050	COG0728	peptidoglycan biosynthetic process
I0J99_RS02060	COG0180	Tryptophanyl-tRNA synthetase
I0J99_RS02070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I0J99_RS02090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0J99_RS02095	COG1702	phosphate starvation-inducible protein PhoH
I0J99_RS02100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I0J99_RS02105	COG4535	Mg2 and Co2 transporter CorC
I0J99_RS02110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I0J99_RS02115	COG1396	sequence-specific DNA binding
I0J99_RS02120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I0J99_RS02125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I0J99_RS02135	COG0071	Belongs to the small heat shock protein (HSP20) family
I0J99_RS02140	COG1957	nucleoside hydrolase
I0J99_RS02145	COG0840	transmembrane signaling receptor activity
I0J99_RS02150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0J99_RS02160	COG0242	peptide deformylase activity
I0J99_RS02165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0J99_RS02170	COG0101	tRNA pseudouridine synthase activity
I0J99_RS02180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0J99_RS02195	COG0657	acetylesterase activity
I0J99_RS02200	COG0583	DNA-binding transcription factor activity
I0J99_RS02205	COG1733	regulation of RNA biosynthetic process
I0J99_RS02215	COG0513	Belongs to the DEAD box helicase family
I0J99_RS02225	COG2171	N-acyltransferase activity
I0J99_RS02245	COG2169	Transcriptional regulator
I0J99_RS02245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0J99_RS02255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I0J99_RS02265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0J99_RS02275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I0J99_RS02280	COG0706	membrane insertase activity
I0J99_RS02285	COG0594	ribonuclease P activity
I0J99_RS02290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I0J99_RS02310	COG5002	protein histidine kinase activity
I0J99_RS02350	COG1304	FMN binding
I0J99_RS02415	COG0667	Aldo Keto reductase
I0J99_RS02450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I0J99_RS02460	COG2259	Doxx family
I0J99_RS02490	COG1072	(Pantothenic acid kinase))
I0J99_RS02495	COG0418	dihydroorotase activity
I0J99_RS02500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I0J99_RS02510	COG0166	Belongs to the GPI family
I0J99_RS02515	COG0318	PFAM AMP-dependent synthetase and ligase
I0J99_RS02520	COG2814	Major facilitator Superfamily
I0J99_RS02525	COG0628	permease
I0J99_RS02540	COG4589	Belongs to the CDS family
I0J99_RS02565	COG2326	polyphosphate kinase activity
I0J99_RS02570	COG5002	protein histidine kinase activity
I0J99_RS02580	COG0573	inorganic phosphate transmembrane transporter activity
I0J99_RS02590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I0J99_RS02595	COG0704	Plays a role in the regulation of phosphate uptake
I0J99_RS02600	COG0745	RESPONSE REGULATOR receiver
I0J99_RS02615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0J99_RS02620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I0J99_RS02630	COG2967	ApaG domain
I0J99_RS02635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I0J99_RS02645	COG0717	Belongs to the dCTP deaminase family
I0J99_RS02655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS02680	COG0387	Pfam Sodium calcium exchanger
I0J99_RS02695	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0J99_RS02695	COG1024	Enoyl-CoA hydratase
I0J99_RS02700	COG0183	Belongs to the thiolase family
I0J99_RS02705	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS02715	COG0730	response to heat
I0J99_RS02735	COG1201	RNA secondary structure unwinding
I0J99_RS02740	COG1959	2 iron, 2 sulfur cluster binding
I0J99_RS02745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0J99_RS02770	COG0534	Mate efflux family protein
I0J99_RS02775	COG0167	dihydroorotate dehydrogenase activity
I0J99_RS02800	COG1970	mechanosensitive ion channel activity
I0J99_RS02805	COG0436	Aminotransferase
I0J99_RS02820	COG1294	oxidase, subunit
I0J99_RS02825	COG1271	oxidase subunit
I0J99_RS02830	COG1473	amidohydrolase
I0J99_RS02840	COG4215	(ABC) transporter
I0J99_RS02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS02855	COG1309	transcriptional regulator
I0J99_RS02885	COG1959	2 iron, 2 sulfur cluster binding
I0J99_RS02890	COG0517	IMP dehydrogenase activity
I0J99_RS02890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I0J99_RS02900	COG1368	sulfuric ester hydrolase activity
I0J99_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS02910	COG0156	8-amino-7-oxononanoate synthase activity
I0J99_RS02925	COG1335	isochorismatase
I0J99_RS02930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I0J99_RS02960	COG2132	Multicopper oxidase
I0J99_RS02990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I0J99_RS03000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I0J99_RS03005	COG5328	Belongs to the UPF0262 family
I0J99_RS03015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I0J99_RS03020	COG0424	maF-like protein
I0J99_RS03025	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I0J99_RS03075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I0J99_RS03090	COG4952	isomerase
I0J99_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS03095	COG3347	Dehydrogenase
I0J99_RS03100	COG1349	DNA-binding transcription factor activity
I0J99_RS03110	COG1129	ABC transporter
I0J99_RS03115	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS03125	COG3254	rhamnose metabolic process
I0J99_RS03135	COG0840	transmembrane signaling receptor activity
I0J99_RS03145	COG0745	RESPONSE REGULATOR receiver
I0J99_RS03150	COG2198	Histidine kinase
I0J99_RS03150	COG0643	Histidine kinase
I0J99_RS03155	COG0835	chemotaxis
I0J99_RS03160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I0J99_RS03165	COG2201	protein-glutamate methylesterase activity
I0J99_RS03170	COG0745	RESPONSE REGULATOR receiver
I0J99_RS03175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I0J99_RS03185	COG1766	The M ring may be actively involved in energy transduction
I0J99_RS03190	COG2771	luxR family
I0J99_RS03205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0J99_RS03210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0J99_RS03215	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0J99_RS03220	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0J99_RS03225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I0J99_RS03235	COG4786	Flagellar basal body rod
I0J99_RS03240	COG1157	protein secretion by the type III secretion system
I0J99_RS03250	COG1815	bacterial-type flagellum-dependent cell motility
I0J99_RS03255	COG1558	bacterial-type flagellum-dependent cell motility
I0J99_RS03260	COG1677	Flagellar hook-basal body complex protein FliE
I0J99_RS03265	COG4786	Flagellar basal body rod
I0J99_RS03270	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I0J99_RS03275	COG1706	bacterial-type flagellum-dependent cell motility
I0J99_RS03285	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I0J99_RS03295	COG1338	Plays a role in the flagellum-specific transport system
I0J99_RS03300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0J99_RS03305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0J99_RS03310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0J99_RS03315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0J99_RS03325	COG1360	Flagellar Motor Protein
I0J99_RS03350	COG1749	Flagellar hook protein flgE
I0J99_RS03370	COG5443	negative regulation of bacterial-type flagellum assembly
I0J99_RS03375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I0J99_RS03380	COG4794	Type iii secretion
I0J99_RS03385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0J99_RS03420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I0J99_RS03425	COG1609	Transcriptional regulator
I0J99_RS03435	COG1653	transport
I0J99_RS03440	COG1175	transmembrane transport
I0J99_RS03445	COG0395	ABC-type sugar transport system, permease component
I0J99_RS03450	COG0366	Alpha amylase catalytic
I0J99_RS03455	COG3842	ATPase activity
I0J99_RS03470	COG0129	dihydroxy-acid dehydratase activity
I0J99_RS03475	COG0363	glucosamine-6-phosphate deaminase activity
I0J99_RS03480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0J99_RS03485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS03495	COG2081	HI0933 family
I0J99_RS03505	COG0840	transmembrane signaling receptor activity
I0J99_RS03505	COG2972	Histidine kinase
I0J99_RS03520	COG2224	Isocitrate lyase
I0J99_RS03525	COG3800	Transcriptional regulator
I0J99_RS03525	COG1396	sequence-specific DNA binding
I0J99_RS03535	COG3842	ATPase activity
I0J99_RS03540	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0J99_RS03545	COG1177	transmembrane transport
I0J99_RS03555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0J99_RS03560	COG1178	ABC-type Fe3 transport system permease component
I0J99_RS03565	COG2205	protein histidine kinase activity
I0J99_RS03600	COG4269	membrane
I0J99_RS03610	COG1840	ABC-type Fe3 transport system, periplasmic component
I0J99_RS03615	COG1959	2 iron, 2 sulfur cluster binding
I0J99_RS03620	COG0747	negative chemotaxis
I0J99_RS03625	COG0601	transmembrane transport
I0J99_RS03630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS03635	COG0444	Belongs to the ABC transporter superfamily
I0J99_RS03640	COG4608	Belongs to the ABC transporter superfamily
I0J99_RS03645	COG0251	oxidation-reduction process
I0J99_RS03660	COG0784	Response regulator, receiver
I0J99_RS03680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS03690	COG1285	pathogenesis
I0J99_RS03745	COG2059	Chromate
I0J99_RS03775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I0J99_RS03785	COG0477	Major facilitator Superfamily
I0J99_RS03805	COG0412	Dienelactone hydrolase
I0J99_RS03810	COG0583	DNA-binding transcription factor activity
I0J99_RS03815	COG0753	catalase activity
I0J99_RS03820	COG0583	DNA-binding transcription factor activity
I0J99_RS03855	COG0306	phosphate transporter
I0J99_RS03865	COG1725	Transcriptional regulator
I0J99_RS03875	COG0583	DNA-binding transcription factor activity
I0J99_RS03880	COG0277	FAD linked oxidase domain protein
I0J99_RS03885	COG0277	FAD linked oxidase domain protein
I0J99_RS03890	COG0247	lactate metabolic process
I0J99_RS03900	COG1388	LysM domain
I0J99_RS03900	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS03905	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS03910	COG2818	Glycosylase
I0J99_RS03915	COG1953	Uracil, thiamine, allantoin
I0J99_RS03930	COG0124	histidyl-tRNA synthetase
I0J99_RS03935	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I0J99_RS03940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I0J99_RS03945	COG0625	glutathione transferase activity
I0J99_RS03955	COG0459	protein refolding
I0J99_RS03960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I0J99_RS03975	COG0196	riboflavin kinase activity
I0J99_RS03980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I0J99_RS03995	COG0590	tRNA wobble adenosine to inosine editing
I0J99_RS04000	COG1187	pseudouridine synthase activity
I0J99_RS04005	COG0742	ribosomal rna small subunit methyltransferase
I0J99_RS04010	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0J99_RS04015	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
I0J99_RS04025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0J99_RS04025	COG0475	glutathione-regulated potassium exporter activity
I0J99_RS04030	COG0312	modulator of DNA gyrase
I0J99_RS04035	COG0483	inositol monophosphate 1-phosphatase activity
I0J99_RS04045	COG1519	Transferase
I0J99_RS04055	COG1663	tetraacyldisaccharide 4'-kinase activity
I0J99_RS04070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I0J99_RS04080	COG5001	Diguanylate cyclase
I0J99_RS04080	COG3300	MHYT domain
I0J99_RS04085	COG0583	DNA-binding transcription factor activity
I0J99_RS04090	COG5598	trimethylamine methyltransferase
I0J99_RS04105	COG0129	dihydroxy-acid dehydratase activity
I0J99_RS04110	COG3386	PFAM SMP-30 Gluconolaconase
I0J99_RS04115	COG0800	Aldolase
I0J99_RS04120	COG3734	2-keto-3-deoxy-galactonokinase
I0J99_RS04125	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS04130	COG1414	Transcriptional regulator
I0J99_RS04140	COG2771	luxR family
I0J99_RS04145	COG0489	protein tyrosine kinase activity
I0J99_RS04150	COG0598	Magnesium transport protein CorA
I0J99_RS04155	COG3158	transport of potassium into the cell
I0J99_RS04170	COG0356	it plays a direct role in the translocation of protons across the membrane
I0J99_RS04175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I0J99_RS04180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I0J99_RS04185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I0J99_RS04190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I0J99_RS04210	COG0521	Mo-molybdopterin cofactor biosynthetic process
I0J99_RS04215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I0J99_RS04225	COG0142	geranyltranstransferase activity
I0J99_RS04250	COG0752	glycyl-tRNA synthetase alpha subunit
I0J99_RS04260	COG1704	LemA family
I0J99_RS04270	COG0751	glycine-tRNA ligase activity
I0J99_RS04275	COG1683	Conserved Protein
I0J99_RS04285	COG0151	Belongs to the GarS family
I0J99_RS04300	COG2223	nitrite transmembrane transporter activity
I0J99_RS04305	COG4977	sequence-specific DNA binding
I0J99_RS04310	COG3713	MltA-interacting MipA family protein
I0J99_RS04315	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I0J99_RS04335	COG0009	L-threonylcarbamoyladenylate synthase
I0J99_RS04345	COG4638	Rieske (2fe-2S)
I0J99_RS04350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I0J99_RS04370	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS04390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I0J99_RS04400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I0J99_RS04405	COG1741	Belongs to the pirin family
I0J99_RS04410	COG1722	exodeoxyribonuclease VII activity
I0J99_RS04415	COG0123	including yeast histone deacetylase and acetoin utilization protein
I0J99_RS04420	COG1063	alcohol dehydrogenase
I0J99_RS04430	COG0183	Belongs to the thiolase family
I0J99_RS04435	COG0318	PFAM AMP-dependent synthetase and ligase
I0J99_RS04440	COG1268	BioY protein
I0J99_RS04445	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I0J99_RS04450	COG1122	ATPase activity
I0J99_RS04455	COG3214	Protein conserved in bacteria
I0J99_RS04460	COG0312	modulator of DNA gyrase
I0J99_RS04475	COG0259	pyridoxamine-phosphate oxidase activity
I0J99_RS04485	COG0484	heat shock protein binding
I0J99_RS04490	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I0J99_RS04505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I0J99_RS04510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I0J99_RS04510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I0J99_RS04520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0J99_RS04520	COG1565	acr, cog1565
I0J99_RS04525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0J99_RS04530	COG0109	protoheme IX farnesyltransferase activity
I0J99_RS04540	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I0J99_RS04560	COG3346	SURF1 family
I0J99_RS04565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I0J99_RS04570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0J99_RS04575	COG0328	RNA-DNA hybrid ribonuclease activity
I0J99_RS04580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I0J99_RS04580	COG0678	peroxiredoxin activity
I0J99_RS04590	COG1678	Uncharacterized ACR, COG1678
I0J99_RS04595	COG5001	Diguanylate cyclase
I0J99_RS04600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0J99_RS04605	COG0612	Peptidase, M16
I0J99_RS04625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0J99_RS04635	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I0J99_RS04645	COG1194	a g-specific adenine glycosylase
I0J99_RS04665	COG1196	nuclear chromosome segregation
I0J99_RS04670	COG0574	Belongs to the PEP-utilizing enzyme family
I0J99_RS04670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I0J99_RS04705	COG3264	Mechanosensitive ion channel
I0J99_RS04705	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I0J99_RS04730	COG2895	sulfate adenylyltransferase (ATP) activity
I0J99_RS04735	COG0175	sulfate reduction
I0J99_RS04740	COG0175	sulfate reduction
I0J99_RS04755	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I0J99_RS04760	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS04765	COG3119	arylsulfatase activity
I0J99_RS04770	COG1309	transcriptional regulator
I0J99_RS04780	COG5001	Diguanylate cyclase
I0J99_RS04780	COG3300	MHYT domain
I0J99_RS04805	COG0583	DNA-binding transcription factor activity
I0J99_RS04820	COG1388	LysM domain
I0J99_RS04820	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS04825	COG1846	Transcriptional regulator
I0J99_RS04830	COG1764	response to oxidative stress
I0J99_RS04835	COG2824	Alkylphosphonate utilization operon protein PhnA
I0J99_RS04840	COG0433	COG0433 Predicted ATPase
I0J99_RS04850	COG0656	L-ascorbic acid biosynthetic process
I0J99_RS04855	COG4106	trans-aconitate 2-methyltransferase activity
I0J99_RS04885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0J99_RS04905	COG2010	Cytochrome c
I0J99_RS04915	COG0789	Transcriptional regulator
I0J99_RS04925	COG4993	Dehydrogenase
I0J99_RS04930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I0J99_RS04945	COG2514	catechol 2,3-dioxygenase activity
I0J99_RS04965	COG1272	protein, Hemolysin III
I0J99_RS04975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0J99_RS04980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0J99_RS04980	COG2111	Na H antiporter
I0J99_RS04985	COG2111	Na H antiporter
I0J99_RS04990	COG1006	Multisubunit Na H antiporter MnhC subunit
I0J99_RS04995	COG0651	ATP synthesis coupled electron transport
I0J99_RS05000	COG1863	multisubunit Na H antiporter MnhE subunit
I0J99_RS05005	COG2212	antiporter activity
I0J99_RS05010	COG1320	monovalent cation:proton antiporter activity
I0J99_RS05015	COG4957	zinc ion binding
I0J99_RS05020	COG2166	iron-sulfur cluster assembly
I0J99_RS05030	COG2205	protein histidine kinase activity
I0J99_RS05075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0J99_RS05080	COG2983	Belongs to the UPF0260 family
I0J99_RS05115	COG4235	cytochrome complex assembly
I0J99_RS05120	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I0J99_RS05125	COG1138	Cytochrome C-type biogenesis protein
I0J99_RS05130	COG3088	subunit of a heme lyase
I0J99_RS05135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0J99_RS05140	COG0745	RESPONSE REGULATOR receiver
I0J99_RS05145	COG2205	protein histidine kinase activity
I0J99_RS05150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I0J99_RS05155	COG2205	protein histidine kinase activity
I0J99_RS05155	COG2202	Pas domain
I0J99_RS05160	COG0308	aminopeptidase N
I0J99_RS05170	COG2814	Major facilitator Superfamily
I0J99_RS05185	COG1573	uracil-dna glycosylase
I0J99_RS05190	COG0443	Heat shock 70 kDa protein
I0J99_RS05205	COG4176	ABC-type proline glycine betaine transport system permease component
I0J99_RS05215	COG1733	regulation of RNA biosynthetic process
I0J99_RS05225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I0J99_RS05230	COG0463	Glycosyl transferase, family 2
I0J99_RS05240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0J99_RS05245	COG1742	UPF0060 membrane protein
I0J99_RS05260	COG0625	glutathione transferase activity
I0J99_RS05280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0J99_RS05295	COG3093	addiction module antidote protein HigA
I0J99_RS05300	COG3549	Plasmid maintenance system killer
I0J99_RS05310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I0J99_RS05315	COG4974	Belongs to the 'phage' integrase family
I0J99_RS05320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I0J99_RS05330	COG0741	lytic transglycosylase activity
I0J99_RS05335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS05340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I0J99_RS05355	COG1758	RNA polymerase activity
I0J99_RS05385	COG0736	holo-[acyl-carrier-protein] synthase activity
I0J99_RS05390	COG0681	Belongs to the peptidase S26 family
I0J99_RS05395	COG0571	ribonuclease III activity
I0J99_RS05400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I0J99_RS05405	COG0431	NADPH-dependent FMN reductase
I0J99_RS05425	COG0584	glycerophosphoryl diester phosphodiesterase
I0J99_RS05430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0J99_RS05435	COG2183	response to ionizing radiation
I0J99_RS05445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I0J99_RS05450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS05470	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS05475	COG1381	Involved in DNA repair and RecF pathway recombination
I0J99_RS05490	COG1418	mRNA catabolic process
I0J99_RS05505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I0J99_RS05510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I0J99_RS05520	COG2032	superoxide dismutase activity
I0J99_RS05525	COG2274	protein secretion by the type I secretion system
I0J99_RS05550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I0J99_RS05575	COG1051	belongs to the nudix hydrolase family
I0J99_RS05590	COG0215	cysteine-tRNA ligase activity
I0J99_RS05615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I0J99_RS05620	COG2962	Rard protein
I0J99_RS05635	COG5265	(ABC) transporter
I0J99_RS05640	COG0688	phosphatidylethanolamine metabolic process
I0J99_RS05645	COG1183	phosphatidylcholine synthase activity
I0J99_RS05650	COG4221	oxidoreductase activity
I0J99_RS05655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I0J99_RS05670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0J99_RS05690	COG0305	Participates in initiation and elongation during chromosome replication
I0J99_RS05710	COG0359	binds to the 23S rRNA
I0J99_RS05720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I0J99_RS05725	COG0360	Binds together with S18 to 16S ribosomal RNA
I0J99_RS05735	COG0667	Aldo Keto reductase
I0J99_RS05740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I0J99_RS05750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0J99_RS05755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0J99_RS05760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I0J99_RS05765	COG1561	YicC-like family, N-terminal region
I0J99_RS05770	COG0194	GDP metabolic process
I0J99_RS05775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I0J99_RS05780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I0J99_RS05805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I0J99_RS05830	COG0488	(ABC) transporter
I0J99_RS05840	COG0318	PFAM AMP-dependent synthetase and ligase
I0J99_RS05855	COG0105	UTP biosynthetic process
I0J99_RS05875	COG0314	molybdopterin synthase activity
I0J99_RS05890	COG0322	excinuclease ABC activity
I0J99_RS05895	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS05920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I0J99_RS05925	COG0243	molybdopterin cofactor binding
I0J99_RS05930	COG0494	nUDIX hydrolase
I0J99_RS05945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I0J99_RS05950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I0J99_RS05955	COG0628	permease
I0J99_RS05965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I0J99_RS05970	COG0248	Ppx GppA phosphatase
I0J99_RS05980	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I0J99_RS05985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I0J99_RS05990	COG2132	Multicopper oxidase
I0J99_RS06000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I0J99_RS06010	COG0459	protein refolding
I0J99_RS06025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0J99_RS06040	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I0J99_RS06050	COG0113	porphobilinogen synthase activity
I0J99_RS06065	COG2989	Protein conserved in bacteria
I0J99_RS06070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I0J99_RS06075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I0J99_RS06080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0J99_RS06080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0J99_RS06095	COG0519	Catalyzes the synthesis of GMP from XMP
I0J99_RS06105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I0J99_RS06110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I0J99_RS06115	COG2814	Major facilitator Superfamily
I0J99_RS06120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I0J99_RS06140	COG0416	fatty acid biosynthetic process
I0J99_RS06145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0J99_RS06150	COG0776	regulation of translation
I0J99_RS06185	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS06200	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS06220	COG0110	maltose O-acetyltransferase activity
I0J99_RS06235	COG1612	heme a metabolic process
I0J99_RS06240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I0J99_RS06245	COG0010	Belongs to the arginase family
I0J99_RS06250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I0J99_RS06255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I0J99_RS06265	COG1024	Enoyl-CoA hydratase
I0J99_RS06275	COG1832	CoA-binding protein
I0J99_RS06290	COG2124	cytochrome p450
I0J99_RS06300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0J99_RS06305	COG0740	serine-type endopeptidase activity
I0J99_RS06310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I0J99_RS06315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I0J99_RS06320	COG0776	regulation of translation
I0J99_RS06335	COG0420	3'-5' exonuclease activity
I0J99_RS06340	COG4717	serine-type aminopeptidase activity
I0J99_RS06365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0J99_RS06370	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0J99_RS06375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0J99_RS06380	COG0649	NAD binding
I0J99_RS06390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I0J99_RS06395	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I0J99_RS06400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I0J99_RS06400	COG3743	rRNA binding
I0J99_RS06410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I0J99_RS06415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0J99_RS06425	COG0713	ATP synthesis coupled electron transport
I0J99_RS06440	COG1007	ATP synthesis coupled electron transport
I0J99_RS06455	COG0346	lactoylglutathione lyase activity
I0J99_RS06480	COG0442	prolyl-tRNA aminoacylation
I0J99_RS06490	COG1136	(ABC) transporter
I0J99_RS06505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I0J99_RS06515	COG0784	Response regulator, receiver
I0J99_RS06525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I0J99_RS06545	COG0557	exoribonuclease II activity
I0J99_RS06550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0J99_RS06550	COG1754	DNA topoisomerase type I activity
I0J99_RS06555	COG0758	DNA mediated transformation
I0J99_RS06560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I0J99_RS06565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I0J99_RS06570	COG0540	Belongs to the ATCase OTCase family
I0J99_RS06575	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS06595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I0J99_RS06600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I0J99_RS06605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I0J99_RS06610	COG0154	amidase activity
I0J99_RS06615	COG3811	Belongs to the UPF0386 family
I0J99_RS06620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I0J99_RS06640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I0J99_RS06645	COG0439	Biotin carboxylase
I0J99_RS06650	COG0511	ligase activity, forming carbon-carbon bonds
I0J99_RS06655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I0J99_RS06665	COG0436	Aminotransferase
I0J99_RS06680	COG1530	ribonuclease E activity
I0J99_RS06685	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0J99_RS06690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0J99_RS06710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I0J99_RS06730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I0J99_RS06740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0J99_RS06755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I0J99_RS06765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS06785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I0J99_RS06790	COG0081	regulation of translation
I0J99_RS06795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I0J99_RS06800	COG0222	ribosome binding
I0J99_RS06805	COG0085	RNA polymerase activity
I0J99_RS06810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I0J99_RS06820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I0J99_RS06825	COG0049	tRNA binding
I0J99_RS06830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I0J99_RS06835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I0J99_RS06840	COG0051	transcription antitermination factor activity, RNA binding
I0J99_RS06845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I0J99_RS06850	COG0088	Forms part of the polypeptide exit tunnel
I0J99_RS06855	COG0089	rRNA binding
I0J99_RS06860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I0J99_RS06865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I0J99_RS06870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I0J99_RS06875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I0J99_RS06880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I0J99_RS06885	COG0255	Belongs to the universal ribosomal protein uL29 family
I0J99_RS06890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I0J99_RS06895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I0J99_RS06900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I0J99_RS06905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I0J99_RS06910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I0J99_RS06915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I0J99_RS06920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I0J99_RS06925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I0J99_RS06930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I0J99_RS06935	COG1841	ribosomal large subunit assembly
I0J99_RS06940	COG0200	Binds to the 23S rRNA
I0J99_RS06950	COG0563	adenylate kinase activity
I0J99_RS06955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I0J99_RS06960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I0J99_RS06965	COG0202	RNA polymerase activity
I0J99_RS06970	COG0203	ribosomal protein L17
I0J99_RS06975	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I0J99_RS06980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I0J99_RS06985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0J99_RS06990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I0J99_RS07005	COG0546	phosphoglycolate phosphatase activity
I0J99_RS07010	COG0564	pseudouridine synthase activity
I0J99_RS07015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I0J99_RS07020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I0J99_RS07030	COG1671	Belongs to the UPF0178 family
I0J99_RS07035	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I0J99_RS07045	COG0321	lipoyl(octanoyl) transferase activity
I0J99_RS07055	COG2766	serine protein kinase
I0J99_RS07060	COG2718	Belongs to the UPF0229 family
I0J99_RS07065	COG2719	SpoVR family
I0J99_RS07080	COG0242	peptide deformylase activity
I0J99_RS07085	COG2239	Acts as a magnesium transporter
I0J99_RS07110	COG1760	l-serine dehydratase
I0J99_RS07155	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I0J99_RS07160	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0J99_RS07165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I0J99_RS07170	COG0302	gtp cyclohydrolase
I0J99_RS07180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I0J99_RS07195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0J99_RS07235	COG0187	DNA topoisomerase II activity
I0J99_RS07260	COG0149	triose-phosphate isomerase activity
I0J99_RS07265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0J99_RS07270	COG0504	CTP synthase activity
I0J99_RS07280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I0J99_RS07285	COG0148	phosphopyruvate hydratase activity
I0J99_RS07295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0J99_RS07300	COG0022	dehydrogenase e1 component
I0J99_RS07300	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0J99_RS07305	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0J99_RS07320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0J99_RS07330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I0J99_RS07340	COG2867	negative regulation of translational initiation
I0J99_RS07345	COG1546	Belongs to the CinA family
I0J99_RS07345	COG1058	Belongs to the CinA family
I0J99_RS07350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I0J99_RS07350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I0J99_RS07360	COG3852	Histidine kinase
I0J99_RS07365	COG2204	response regulator
I0J99_RS07370	COG5000	phosphorelay sensor kinase activity
I0J99_RS07375	COG2204	response regulator
I0J99_RS07380	COG0569	domain protein
I0J99_RS07385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0J99_RS07390	COG1923	regulation of RNA biosynthetic process
I0J99_RS07395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0J99_RS07400	COG2801	Transposase and inactivated derivatives
I0J99_RS07400	COG3415	Transposase
I0J99_RS07405	COG3956	TIGRFAM MazG family protein
I0J99_RS07415	COG1648	precorrin-2 dehydrogenase activity
I0J99_RS07415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I0J99_RS07425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0J99_RS07445	COG1126	abc transporter atp-binding protein
I0J99_RS07450	COG0765	amino acid transport
I0J99_RS07455	COG4597	amino acid ABC transporter
I0J99_RS07460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS07465	COG0626	cystathionine gamma-synthase activity
I0J99_RS07480	COG0596	Alpha beta hydrolase
I0J99_RS07485	COG1045	serine acetyltransferase
I0J99_RS07500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I0J99_RS07520	COG0537	adenosine 5'-monophosphoramidase activity
I0J99_RS07545	COG0052	Belongs to the universal ribosomal protein uS2 family
I0J99_RS07550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I0J99_RS07555	COG0528	UMP kinase activity
I0J99_RS07560	COG0233	cytoplasmic translational termination
I0J99_RS07565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I0J99_RS07575	COG0750	zinc metalloprotease
I0J99_RS07585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0J99_RS07590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0J99_RS07595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0J99_RS07605	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I0J99_RS07615	COG0372	Belongs to the citrate synthase family
I0J99_RS07630	COG0848	biopolymer transport protein
I0J99_RS07635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I0J99_RS07650	COG0525	valine-tRNA ligase activity
I0J99_RS07660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I0J99_RS07670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0J99_RS07680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I0J99_RS07685	COG0018	arginyl-trna synthetase
I0J99_RS07695	COG1472	Belongs to the glycosyl hydrolase 3 family
I0J99_RS07700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I0J99_RS07705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I0J99_RS07710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I0J99_RS07715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I0J99_RS07720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I0J99_RS07725	COG0805	protein transport
I0J99_RS07730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I0J99_RS07735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I0J99_RS07740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I0J99_RS07760	COG1862	Preprotein translocase
I0J99_RS07785	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I0J99_RS07805	COG0544	peptidyl-prolyl cis-trans isomerase activity
I0J99_RS07815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I0J99_RS07815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I0J99_RS07820	COG0509	glycine decarboxylation via glycine cleavage system
I0J99_RS07825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0J99_RS07855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I0J99_RS07865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I0J99_RS07870	COG0629	single-stranded DNA binding
I0J99_RS07875	COG2095	MarC family integral membrane protein
I0J99_RS07880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0J99_RS07900	COG1902	pentaerythritol trinitrate reductase activity
I0J99_RS07910	COG0583	DNA-binding transcription factor activity
I0J99_RS07915	COG0492	ferredoxin-NADP+ reductase activity
I0J99_RS07920	COG1522	sequence-specific DNA binding
I0J99_RS07925	COG0463	Glycosyl transferase, family 2
I0J99_RS07930	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS07935	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS07940	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS07945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I0J99_RS07960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I0J99_RS07970	COG2321	neutral zinc metallopeptidase
I0J99_RS07980	COG0534	Mate efflux family protein
I0J99_RS07990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I0J99_RS08005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I0J99_RS08010	COG0343	queuine tRNA-ribosyltransferase activity
I0J99_RS08020	COG0300	oxidoreductase activity
I0J99_RS08040	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS08040	COG1388	LysM domain
I0J99_RS08070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0J99_RS08085	COG2801	Transposase and inactivated derivatives
I0J99_RS08095	COG0084	hydrolase, TatD family'
I0J99_RS08100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0J99_RS08120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I0J99_RS08130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I0J99_RS08170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I0J99_RS08200	COG2076	Multidrug Resistance protein
I0J99_RS08220	COG4221	oxidoreductase activity
I0J99_RS08230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I0J99_RS08235	COG2897	thiosulfate sulfurtransferase activity
I0J99_RS08250	COG0686	Belongs to the AlaDH PNT family
I0J99_RS08255	COG1522	sequence-specific DNA binding
I0J99_RS08260	COG0737	Belongs to the 5'-nucleotidase family
I0J99_RS08270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0J99_RS08275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0J99_RS08285	COG4974	Belongs to the 'phage' integrase family
I0J99_RS08370	COG3795	YCII-related domain
I0J99_RS08395	COG0655	NAD(P)H dehydrogenase (quinone) activity
I0J99_RS08400	COG1546	Belongs to the CinA family
I0J99_RS08400	COG1058	Belongs to the CinA family
I0J99_RS08405	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I0J99_RS08410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I0J99_RS08410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I0J99_RS08415	COG0347	Belongs to the P(II) protein family
I0J99_RS08420	COG0174	glutamine synthetase
I0J99_RS08475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I0J99_RS08480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I0J99_RS08485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I0J99_RS08495	COG3153	acetyltransferase
I0J99_RS08500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I0J99_RS08505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I0J99_RS08515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0J99_RS08520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I0J99_RS08525	COG0134	indole-3-glycerol-phosphate synthase activity
I0J99_RS08530	COG0315	cyclic pyranopterin monophosphate synthase activity
I0J99_RS08535	COG0303	'Molybdopterin
I0J99_RS08545	COG1253	flavin adenine dinucleotide binding
I0J99_RS08550	COG2186	Transcriptional regulator
I0J99_RS08560	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS08565	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS08570	COG3845	ABC transporter
I0J99_RS08580	COG1183	phosphatidylcholine synthase activity
I0J99_RS08585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0J99_RS08590	COG0679	Auxin Efflux Carrier
I0J99_RS08595	COG0785	Cytochrome C biogenesis protein
I0J99_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS08670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0J99_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS08685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS08700	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS08705	COG3958	Transketolase
I0J99_RS08710	COG3959	Transketolase, thiamine diphosphate binding domain
I0J99_RS08715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS08720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS08725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS08730	COG2084	Dehydrogenase
I0J99_RS08735	COG0583	DNA-binding transcription factor activity
I0J99_RS08750	COG1522	sequence-specific DNA binding
I0J99_RS08775	COG0583	DNA-binding transcription factor activity
I0J99_RS08815	COG1278	Cold shock
I0J99_RS08860	COG0436	Aminotransferase
I0J99_RS08870	COG3243	poly(R)-hydroxyalkanoic acid synthase
I0J99_RS08875	COG1489	DNA binding
I0J99_RS08880	COG0024	Methionine aminopeptidase
I0J99_RS08885	COG2003	Belongs to the UPF0758 family
I0J99_RS08895	COG0316	Belongs to the HesB IscA family
I0J99_RS08900	COG2151	metal-sulfur cluster biosynthetic enzyme
I0J99_RS08905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I0J99_RS08910	COG0719	Fe-S assembly protein
I0J99_RS08915	COG0396	ATPase activity
I0J99_RS08920	COG0719	Fe-S assembly protein
I0J99_RS08930	COG2945	thiolester hydrolase activity
I0J99_RS08940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I0J99_RS08945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I0J99_RS08955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I0J99_RS08960	COG2833	Protein of unknown function (DUF455)
I0J99_RS08965	COG0739	heme binding
I0J99_RS08970	COG0513	Belongs to the DEAD box helicase family
I0J99_RS08985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I0J99_RS08990	COG3608	succinylglutamate desuccinylase aspartoacylase
I0J99_RS08990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I0J99_RS09005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I0J99_RS09010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0J99_RS09020	COG3191	aminopeptidase activity
I0J99_RS09040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I0J99_RS09065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0J99_RS09070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I0J99_RS09105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I0J99_RS09110	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I0J99_RS09115	COG0047	phosphoribosylformylglycinamidine synthase activity
I0J99_RS09130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0J99_RS09140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I0J99_RS09160	COG2814	Major facilitator Superfamily
I0J99_RS09165	COG2814	Major facilitator Superfamily
I0J99_RS09170	COG0483	inositol monophosphate 1-phosphatase activity
I0J99_RS09175	COG0037	tRNA processing
I0J99_RS09180	COG2066	Belongs to the glutaminase family
I0J99_RS09185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I0J99_RS09195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I0J99_RS09200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I0J99_RS09210	COG0538	isocitrate dehydrogenase activity
I0J99_RS09235	COG0659	secondary active sulfate transmembrane transporter activity
I0J99_RS09240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I0J99_RS09245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I0J99_RS09250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0J99_RS09255	COG2313	pseudouridylate synthase activity
I0J99_RS09280	COG3106	COG3106 Predicted ATPase
I0J99_RS09285	COG3768	UPF0283 membrane protein
I0J99_RS09300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I0J99_RS09305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I0J99_RS09320	COG0633	Ferredoxin
I0J99_RS09335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I0J99_RS09335	COG2857	Cytochrome c1
I0J99_RS09350	COG1132	(ABC) transporter
I0J99_RS09355	COG1132	(ABC) transporter
I0J99_RS09360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I0J99_RS09365	COG0431	NADPH-dependent FMN reductase
I0J99_RS09370	COG0789	Transcriptional regulator
I0J99_RS09385	COG0408	coproporphyrinogen oxidase activity
I0J99_RS09405	COG3218	ABC-type transport auxiliary lipoprotein component
I0J99_RS09405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I0J99_RS09415	COG1127	ABC transporter
I0J99_RS09420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I0J99_RS09425	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS09430	COG2814	Major facilitator Superfamily
I0J99_RS09440	COG0281	malic enzyme
I0J99_RS09440	COG0280	phosphate acetyltransferase
I0J99_RS09445	COG2197	response regulator
I0J99_RS09460	COG0778	Nitroreductase
I0J99_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS09480	COG0823	Involved in the tonB-independent uptake of proteins
I0J99_RS09490	COG1368	sulfuric ester hydrolase activity
I0J99_RS09515	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I0J99_RS09530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I0J99_RS09535	COG0546	phosphoglycolate phosphatase activity
I0J99_RS09540	COG2989	Protein conserved in bacteria
I0J99_RS09545	COG0114	fumarate hydratase activity
I0J99_RS09555	COG2267	carboxylic ester hydrolase activity
I0J99_RS09560	COG1846	Transcriptional regulator
I0J99_RS09570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0J99_RS09575	COG0697	spore germination
I0J99_RS09580	COG0746	molybdenum cofactor guanylyltransferase activity
I0J99_RS09585	COG1763	Mo-molybdopterin cofactor biosynthetic process
I0J99_RS09610	COG5425	PFAM Usg family protein
I0J99_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS09630	COG2084	Dehydrogenase
I0J99_RS09640	COG1522	sequence-specific DNA binding
I0J99_RS09645	COG1573	uracil-dna glycosylase
I0J99_RS09660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I0J99_RS09665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I0J99_RS09670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I0J99_RS09685	COG0842	Transport permease protein
I0J99_RS09690	COG1131	(ABC) transporter
I0J99_RS09695	COG0640	Transcriptional regulator
I0J99_RS09750	COG0556	nucleotide-excision repair
I0J99_RS09760	COG0484	heat shock protein binding
I0J99_RS09770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0J99_RS09795	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0J99_RS09805	COG0735	belongs to the Fur family
I0J99_RS09810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0J99_RS09815	COG1121	(ABC) transporter
I0J99_RS09830	COG3507	Belongs to the glycosyl hydrolase 43 family
I0J99_RS09840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS09845	COG2801	Transposase and inactivated derivatives
I0J99_RS09845	COG3415	Transposase
I0J99_RS09850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I0J99_RS09855	COG0667	Aldo Keto reductase
I0J99_RS09870	COG3250	beta-galactosidase activity
I0J99_RS09875	COG3842	ATPase activity
I0J99_RS09880	COG0395	ABC-type sugar transport system, permease component
I0J99_RS09885	COG1175	transmembrane transport
I0J99_RS09905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I0J99_RS09910	COG1115	amino acid carrier protein
I0J99_RS09930	COG1560	Kdo2-lipid A biosynthetic process
I0J99_RS09940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0J99_RS09950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0J99_RS09955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0J99_RS09960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I0J99_RS09970	COG1797	cobyrinic acid a,c-diamide synthase activity
I0J99_RS09990	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS10000	COG0747	negative chemotaxis
I0J99_RS10005	COG0601	transmembrane transport
I0J99_RS10010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS10055	COG0596	Alpha beta hydrolase
I0J99_RS10060	COG1492	cobalamin metabolic process
I0J99_RS10075	COG0517	IMP dehydrogenase activity
I0J99_RS10075	COG4175	Glycine betaine
I0J99_RS10080	COG3609	addiction module antidote protein, CC2985 family
I0J99_RS10095	COG0583	DNA-binding transcription factor activity
I0J99_RS10100	COG1410	methionine synthase
I0J99_RS10100	COG0646	methionine synthase
I0J99_RS10115	COG3698	Phosphodiester glycosidase
I0J99_RS10125	COG5598	trimethylamine methyltransferase
I0J99_RS10130	COG5012	cobalamin binding
I0J99_RS10145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0J99_RS10175	COG0646	methionine synthase
I0J99_RS10175	COG1410	methionine synthase
I0J99_RS10200	COG0640	Transcriptional regulator
I0J99_RS10205	COG0583	DNA-binding transcription factor activity
I0J99_RS10245	COG0745	RESPONSE REGULATOR receiver
I0J99_RS10270	COG0861	Integral membrane protein TerC family
I0J99_RS10275	COG3264	Mechanosensitive ion channel
I0J99_RS10275	COG1196	nuclear chromosome segregation
I0J99_RS10290	COG0471	metal ion transport
I0J99_RS10290	COG3273	potassium ion transport
I0J99_RS10320	COG0463	Glycosyl transferase, family 2
I0J99_RS10430	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
I0J99_RS10435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS10505	COG3179	chitinase
I0J99_RS10705	COG0305	Participates in initiation and elongation during chromosome replication
I0J99_RS10735	COG0270	DNA (cytosine-5-)-methyltransferase activity
I0J99_RS10750	COG3750	Belongs to the UPF0335 family
I0J99_RS10860	COG0384	phenazine biosynthesis protein PhzF
I0J99_RS10895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I0J99_RS10910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I0J99_RS10925	COG3842	ATPase activity
I0J99_RS10930	COG4149	molybdate abc transporter
I0J99_RS10940	COG1278	Cold shock
I0J99_RS10950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I0J99_RS10960	COG0667	Aldo Keto reductase
I0J99_RS10970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0J99_RS10980	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS11000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I0J99_RS11010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS11015	COG1136	(ABC) transporter
I0J99_RS11015	COG0577	efflux transmembrane transporter activity
I0J99_RS11045	COG2271	Major facilitator Superfamily
I0J99_RS11050	COG1737	Transcriptional regulator
I0J99_RS11055	COG1252	NADH dehydrogenase
I0J99_RS11060	COG1522	sequence-specific DNA binding
I0J99_RS11065	COG1794	racemase activity, acting on amino acids and derivatives
I0J99_RS11070	COG1733	regulation of RNA biosynthetic process
I0J99_RS11085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0J99_RS11090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I0J99_RS11135	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I0J99_RS11135	COG1672	PFAM Archaeal ATPase
I0J99_RS11140	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0J99_RS11145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I0J99_RS11150	COG3180	Ammonia monooxygenase
I0J99_RS11170	COG1595	DNA-templated transcription, initiation
I0J99_RS11210	COG1278	Cold shock
I0J99_RS11215	COG0656	L-ascorbic acid biosynthetic process
I0J99_RS11220	COG0440	acetolactate synthase activity
I0J99_RS11225	COG0028	Belongs to the TPP enzyme family
I0J99_RS11245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I0J99_RS11250	COG0560	Phosphoserine phosphatase
I0J99_RS11250	COG3830	Belongs to the UPF0237 family
I0J99_RS11255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0J99_RS11260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0J99_RS11275	COG0330	HflC and HflK could
I0J99_RS11295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I0J99_RS11345	COG3385	transposase activity
I0J99_RS11355	COG0277	FAD linked oxidase domain protein
I0J99_RS11365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0J99_RS11400	COG3706	GGDEF domain
I0J99_RS11420	COG0835	chemotaxis
I0J99_RS11425	COG0840	transmembrane signaling receptor activity
I0J99_RS11435	COG1999	signal sequence binding
I0J99_RS11440	COG2264	protein methyltransferase activity
I0J99_RS11455	COG0006	proline dipeptidase activity
I0J99_RS11475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I0J99_RS11480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I0J99_RS11490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I0J99_RS11500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I0J99_RS11510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I0J99_RS11515	COG0849	cell division
I0J99_RS11520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I0J99_RS11525	COG1181	Belongs to the D-alanine--D-alanine ligase family
I0J99_RS11530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I0J99_RS11535	COG0477	Major facilitator Superfamily
I0J99_RS11540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I0J99_RS11545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I0J99_RS11550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I0J99_RS11560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I0J99_RS11565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I0J99_RS11575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I0J99_RS11590	COG0275	rRNA processing
I0J99_RS11595	COG2001	Belongs to the MraZ family
I0J99_RS11615	COG3023	N-Acetylmuramoyl-L-alanine amidase
I0J99_RS11620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I0J99_RS11630	COG1280	lysine exporter protein (LysE YggA)
I0J99_RS11685	COG3719	Belongs to the RNase T2 family
I0J99_RS11690	COG2267	carboxylic ester hydrolase activity
I0J99_RS11700	COG0028	Belongs to the TPP enzyme family
I0J99_RS11715	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS11720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS11735	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS11740	COG0174	glutamine synthetase
I0J99_RS11775	COG3842	ATPase activity
I0J99_RS11780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I0J99_RS11795	COG4774	siderophore transport
I0J99_RS11800	COG3328	transposase activity
I0J99_RS11810	COG0149	triose-phosphate isomerase activity
I0J99_RS11815	COG1349	DNA-binding transcription factor activity
I0J99_RS11830	COG1070	Carbohydrate kinase
I0J99_RS11845	COG0235	Class ii aldolase
I0J99_RS11865	COG3842	ATPase activity
I0J99_RS11875	COG1175	transmembrane transport
I0J99_RS11880	COG1653	transport
I0J99_RS11890	COG2197	response regulator
I0J99_RS11895	COG3842	ATPase activity
I0J99_RS11915	COG1177	transmembrane transport
I0J99_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS11930	COG3246	L-lysine catabolic process to acetate
I0J99_RS11935	COG0824	Thioesterase
I0J99_RS11935	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0J99_RS11940	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS11955	COG0747	negative chemotaxis
I0J99_RS11965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS12000	COG0583	DNA-binding transcription factor activity
I0J99_RS12005	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I0J99_RS12010	COG3842	ATPase activity
I0J99_RS12015	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0J99_RS12020	COG1177	transmembrane transport
I0J99_RS12025	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS12090	COG1024	Enoyl-CoA hydratase
I0J99_RS12205	COG1696	Membrane protein involved in D-alanine export
I0J99_RS12245	COG2968	Membrane
I0J99_RS12260	COG0432	Pfam Uncharacterised protein family UPF0047
I0J99_RS12265	COG5507	3-demethylubiquinone-9 3-methyltransferase
I0J99_RS12280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0J99_RS12285	COG1063	alcohol dehydrogenase
I0J99_RS12295	COG0514	ATP-dependent DNA helicase (RecQ)
I0J99_RS12300	COG0358	DNA primase activity
I0J99_RS12310	COG0505	Belongs to the CarA family
I0J99_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS12325	COG2084	Dehydrogenase
I0J99_RS12330	COG0436	Aminotransferase
I0J99_RS12345	COG2133	pyrroloquinoline quinone binding
I0J99_RS12355	COG1278	Cold shock
I0J99_RS12365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0J99_RS12385	COG1846	Transcriptional regulator
I0J99_RS12390	COG0745	RESPONSE REGULATOR receiver
I0J99_RS12395	COG2205	protein histidine kinase activity
I0J99_RS12400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0J99_RS12420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I0J99_RS12430	COG1496	oxidoreductase activity
I0J99_RS12445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I0J99_RS12450	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I0J99_RS12460	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS12470	COG3135	benzoate transporter
I0J99_RS12475	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I0J99_RS12480	COG0193	aminoacyl-tRNA hydrolase activity
I0J99_RS12485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I0J99_RS12510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I0J99_RS12535	COG0714	Associated with various cellular activities
I0J99_RS12560	COG0435	Glutathione S-transferase
I0J99_RS12575	COG1595	DNA-templated transcription, initiation
I0J99_RS12585	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
I0J99_RS12590	COG4423	Transcription factor
I0J99_RS12595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I0J99_RS12600	COG0740	serine-type endopeptidase activity
I0J99_RS12620	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I0J99_RS12625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0J99_RS12630	COG0512	Glutamine amidotransferase of anthranilate synthase
I0J99_RS12630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I0J99_RS12650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I0J99_RS12680	COG1435	thymidine kinase activity
I0J99_RS12715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0J99_RS12720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I0J99_RS12725	COG0366	Alpha amylase catalytic
I0J99_RS12730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0J99_RS12735	COG4608	Belongs to the ABC transporter superfamily
I0J99_RS12740	COG0444	Belongs to the ABC transporter superfamily
I0J99_RS12745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS12750	COG0601	transmembrane transport
I0J99_RS12765	COG2076	Multidrug Resistance protein
I0J99_RS12785	COG2346	COG2346, Truncated hemoglobins
I0J99_RS12835	COG4558	Periplasmic binding protein
I0J99_RS12840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0J99_RS12845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I0J99_RS12860	COG3920	Histidine kinase
I0J99_RS12860	COG2202	Pas domain
I0J99_RS12875	COG0784	Response regulator, receiver
I0J99_RS12905	COG0395	ABC-type sugar transport system, permease component
I0J99_RS12910	COG1175	transmembrane transport
I0J99_RS12940	COG0583	DNA-binding transcription factor activity
I0J99_RS12950	COG1309	transcriptional regulator
I0J99_RS12980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0J99_RS12985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0J99_RS12990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0J99_RS13005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I0J99_RS13010	COG0830	nickel cation binding
I0J99_RS13015	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I0J99_RS13030	COG0804	urea catabolic process
I0J99_RS13035	COG1442	glycosyl transferase family 8
I0J99_RS13040	COG3755	Protein conserved in bacteria
I0J99_RS13045	COG0832	Belongs to the urease beta subunit family
I0J99_RS13050	COG3813	Protein conserved in bacteria
I0J99_RS13055	COG0831	urea catabolic process
I0J99_RS13060	COG0829	nickel cation binding
I0J99_RS13065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0J99_RS13075	COG1846	Transcriptional regulator
I0J99_RS13080	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I0J99_RS13085	COG3668	Plasmid stabilization system
I0J99_RS13125	COG0784	Response regulator, receiver
I0J99_RS13130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0J99_RS13140	COG0400	carboxylic ester hydrolase activity
I0J99_RS13150	COG0346	lactoylglutathione lyase activity
I0J99_RS13155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0J99_RS13165	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0J99_RS13170	COG3842	ATPase activity
I0J99_RS13190	COG0436	Aminotransferase
I0J99_RS13210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS13215	COG0174	glutamine synthetase
I0J99_RS13225	COG1725	Transcriptional regulator
I0J99_RS13230	COG0626	cystathionine gamma-synthase activity
I0J99_RS13245	COG0395	ABC-type sugar transport system, permease component
I0J99_RS13250	COG3842	ATPase activity
I0J99_RS13260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0J99_RS13265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0J99_RS13270	COG1845	cytochrome c oxidase, subunit III
I0J99_RS13310	COG1063	alcohol dehydrogenase
I0J99_RS13330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0J99_RS13335	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS13340	COG1129	ABC transporter
I0J99_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS13355	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS13375	COG3842	ATPase activity
I0J99_RS13380	COG3842	ATPase activity
I0J99_RS13390	COG0395	ABC-type sugar transport system, permease component
I0J99_RS13395	COG1175	transmembrane transport
I0J99_RS13410	COG1802	Transcriptional regulator
I0J99_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS13435	COG2140	Oxalate decarboxylase
I0J99_RS13440	COG0800	Aldolase
I0J99_RS13450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0J99_RS13455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I0J99_RS13460	COG1737	Transcriptional regulator
I0J99_RS13465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I0J99_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS13485	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS13490	COG1129	ABC transporter
I0J99_RS13495	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS13505	COG2188	Transcriptional regulator
I0J99_RS13510	COG1070	Carbohydrate kinase
I0J99_RS13515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I0J99_RS13520	COG0477	Major facilitator Superfamily
I0J99_RS13560	COG0174	glutamine synthetase
I0J99_RS13575	COG1335	isochorismatase
I0J99_RS13580	COG0683	leucine binding
I0J99_RS13605	COG1335	isochorismatase
I0J99_RS13615	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS13635	COG0601	transmembrane transport
I0J99_RS13640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS13650	COG1228	amidohydrolase
I0J99_RS13655	COG0444	Belongs to the ABC transporter superfamily
I0J99_RS13660	COG4608	Belongs to the ABC transporter superfamily
I0J99_RS13665	COG1802	Transcriptional regulator
I0J99_RS13680	COG0723	plastoquinol--plastocyanin reductase activity
I0J99_RS13685	COG0583	DNA-binding transcription factor activity
I0J99_RS13690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I0J99_RS13725	COG0739	heme binding
I0J99_RS13730	COG0542	response to heat
I0J99_RS13740	COG2890	protein-(glutamine-N5) methyltransferase activity
I0J99_RS13745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I0J99_RS13750	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I0J99_RS13755	COG0527	aspartate kinase activity
I0J99_RS13765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0J99_RS13775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0J99_RS13790	COG2226	methyltransferase
I0J99_RS13805	COG0494	nUDIX hydrolase
I0J99_RS13815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I0J99_RS13820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0J99_RS13825	COG0653	protein targeting
I0J99_RS13845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0J99_RS13880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I0J99_RS13890	COG0300	oxidoreductase activity
I0J99_RS13900	COG2096	Adenosyltransferase
I0J99_RS13910	COG2086	electron transfer activity
I0J99_RS13915	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I0J99_RS13920	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0J99_RS13925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0J99_RS13930	COG0165	Argininosuccinate lyase
I0J99_RS13960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I0J99_RS13970	COG2884	Cell division ATP-binding protein ftsE
I0J99_RS13990	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I0J99_RS14000	COG0287	Prephenate dehydrogenase
I0J99_RS14005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0J99_RS14010	COG2226	methyltransferase
I0J99_RS14015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0J99_RS14035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I0J99_RS14040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I0J99_RS14070	COG4536	flavin adenine dinucleotide binding
I0J99_RS14075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I0J99_RS14080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I0J99_RS14090	COG3609	addiction module antidote protein, CC2985 family
I0J99_RS14100	COG4974	Belongs to the 'phage' integrase family
I0J99_RS14105	COG0825	malonyl-CoA metabolic process
I0J99_RS14110	COG3034	peptidoglycan biosynthetic process
I0J99_RS14130	COG0523	cobalamin synthesis protein
I0J99_RS14135	COG1686	Belongs to the peptidase S11 family
I0J99_RS14140	COG1473	amidohydrolase
I0J99_RS14150	COG1064	alcohol dehydrogenase
I0J99_RS14155	COG2207	Transcriptional regulator
I0J99_RS14160	COG1522	sequence-specific DNA binding
I0J99_RS14165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0J99_RS14170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS14175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0J99_RS14185	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS14195	COG4176	ABC-type proline glycine betaine transport system permease component
I0J99_RS14200	COG4175	Glycine betaine
I0J99_RS14200	COG0517	IMP dehydrogenase activity
I0J99_RS14205	COG2986	histidine ammonia-lyase
I0J99_RS14210	COG3314	Sporulation integral membrane protein YlbJ
I0J99_RS14260	COG0482	sulfurtransferase activity
I0J99_RS14265	COG2771	luxR family
I0J99_RS14320	COG0564	pseudouridine synthase activity
I0J99_RS14325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0J99_RS14335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I0J99_RS14345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0J99_RS14365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I0J99_RS14370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I0J99_RS14375	COG0037	tRNA processing
I0J99_RS14385	COG2885	chlorophyll binding
I0J99_RS14390	COG0823	Involved in the tonB-independent uptake of proteins
I0J99_RS14415	COG0824	Thioesterase
I0J99_RS14440	COG2255	four-way junction helicase activity
I0J99_RS14445	COG0632	four-way junction helicase activity
I0J99_RS14450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I0J99_RS14455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0J99_RS14460	COG0217	transcriptional regulatory protein
I0J99_RS14475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS14480	COG1692	metallophosphoesterase
I0J99_RS14525	COG0126	phosphoglycerate kinase activity
I0J99_RS14530	COG3588	fructose-bisphosphate aldolase
I0J99_RS14535	COG0384	phenazine biosynthesis protein PhzF
I0J99_RS14565	COG0254	rRNA binding
I0J99_RS14570	COG1132	(ABC) transporter
I0J99_RS14585	COG0483	inositol monophosphate 1-phosphatase activity
I0J99_RS14605	COG0640	Transcriptional regulator
I0J99_RS14620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I0J99_RS14625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I0J99_RS14630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I0J99_RS14635	COG0457	Tetratricopeptide repeat
I0J99_RS14640	COG0469	pyruvate kinase activity
I0J99_RS14660	COG3750	Belongs to the UPF0335 family
I0J99_RS14665	COG3108	Peptidase M15
I0J99_RS14670	COG2204	response regulator
I0J99_RS14680	COG0512	Glutamine amidotransferase of anthranilate synthase
I0J99_RS14680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I0J99_RS14695	COG5310	Homospermidine synthase
I0J99_RS14705	COG0737	Belongs to the 5'-nucleotidase family
I0J99_RS14710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I0J99_RS14715	COG0330	HflC and HflK could
I0J99_RS14720	COG1585	Membrane protein implicated in regulation of membrane protease activity
I0J99_RS14730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0J99_RS14735	COG2951	lytic endotransglycosylase activity
I0J99_RS14750	COG0067	glutamate synthase
I0J99_RS14750	COG0070	glutamate synthase
I0J99_RS14750	COG0069	glutamate synthase activity
I0J99_RS14770	COG2197	response regulator
I0J99_RS14775	COG2267	carboxylic ester hydrolase activity
I0J99_RS14780	COG0601	transmembrane transport
I0J99_RS14785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS14790	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS14800	COG0071	Belongs to the small heat shock protein (HSP20) family
I0J99_RS14830	COG0129	dihydroxy-acid dehydratase activity
I0J99_RS14880	COG0583	DNA-binding transcription factor activity
I0J99_RS14885	COG0667	Aldo Keto reductase
I0J99_RS14895	COG1305	Transglutaminase-like
I0J99_RS14905	COG0058	SHG alpha-glucan phosphorylase activity
I0J99_RS14910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I0J99_RS14915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I0J99_RS14920	COG0297	glycogen (starch) synthase activity
I0J99_RS14925	COG0033	Phosphoglucomutase
I0J99_RS14930	COG1523	belongs to the glycosyl hydrolase 13 family
I0J99_RS14955	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0J99_RS14955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0J99_RS14965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS14970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I0J99_RS15010	COG5001	Diguanylate cyclase
I0J99_RS15015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I0J99_RS15020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0J99_RS15025	COG1609	Transcriptional regulator
I0J99_RS15030	COG1846	Transcriptional regulator
I0J99_RS15040	COG0523	cobalamin synthesis protein
I0J99_RS15055	COG1280	lysine exporter protein (LysE YggA)
I0J99_RS15070	COG0583	DNA-binding transcription factor activity
I0J99_RS15080	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I0J99_RS15110	COG0800	Aldolase
I0J99_RS15115	COG2954	triphosphatase activity
I0J99_RS15125	COG1054	Belongs to the UPF0176 family
I0J99_RS15130	COG1464	Belongs to the NlpA lipoprotein family
I0J99_RS15135	COG2011	ABC-type metal ion transport system permease component
I0J99_RS15140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I0J99_RS15150	COG0673	inositol 2-dehydrogenase activity
I0J99_RS15160	COG2115	Belongs to the xylose isomerase family
I0J99_RS15165	COG1070	Carbohydrate kinase
I0J99_RS15170	COG1609	Transcriptional regulator
I0J99_RS15190	COG1309	transcriptional regulator
I0J99_RS15195	COG2207	Transcriptional regulator
I0J99_RS15195	COG3708	Transcriptional regulator
I0J99_RS15200	COG1253	flavin adenine dinucleotide binding
I0J99_RS15205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I0J99_RS15210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I0J99_RS15230	COG1793	dna ligase
I0J99_RS15230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I0J99_RS15240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0J99_RS15240	COG2111	Na H antiporter
I0J99_RS15245	COG1006	Multisubunit Na H antiporter MnhC subunit
I0J99_RS15250	COG0651	ATP synthesis coupled electron transport
I0J99_RS15255	COG1863	multisubunit Na H antiporter MnhE subunit
I0J99_RS15260	COG2212	antiporter activity
I0J99_RS15265	COG1320	monovalent cation:proton antiporter activity
I0J99_RS15275	COG0583	DNA-binding transcription factor activity
I0J99_RS15320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I0J99_RS15325	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0J99_RS15330	COG4149	molybdate abc transporter
I0J99_RS15335	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I0J99_RS15340	COG2005	Transcriptional regulator
I0J99_RS15340	COG3585	molybdate ion transport
I0J99_RS15355	COG0022	dehydrogenase e1 component
I0J99_RS15375	COG0625	glutathione transferase activity
I0J99_RS15385	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I0J99_RS15405	COG2197	response regulator
I0J99_RS15425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS15445	COG5001	Diguanylate cyclase
I0J99_RS15445	COG3300	MHYT domain
I0J99_RS15450	COG1802	Transcriptional regulator
I0J99_RS15460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0J99_RS15475	COG1126	abc transporter atp-binding protein
I0J99_RS15485	COG0765	amino acid transport
I0J99_RS15490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS15495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS15505	COG0584	glycerophosphoryl diester phosphodiesterase
I0J99_RS15510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS15530	COG0747	negative chemotaxis
I0J99_RS15535	COG2390	Transcriptional regulator
I0J99_RS15590	COG0559	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS15615	COG2942	2-epimerase
I0J99_RS15620	COG4702	Belongs to the UPF0303 family
I0J99_RS15625	COG1940	carbohydrate kinase activity
I0J99_RS15670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I0J99_RS15675	COG0156	8-amino-7-oxononanoate synthase activity
I0J99_RS15705	COG2267	carboxylic ester hydrolase activity
I0J99_RS15725	COG4774	siderophore transport
I0J99_RS15750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I0J99_RS15775	COG0626	cystathionine gamma-synthase activity
I0J99_RS15795	COG0010	Belongs to the arginase family
I0J99_RS15800	COG0835	chemotaxis
I0J99_RS15815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0J99_RS15820	COG3383	formate dehydrogenase (NAD+) activity
I0J99_RS15835	COG0583	DNA-binding transcription factor activity
I0J99_RS15855	COG3842	ATPase activity
I0J99_RS15860	COG3842	ATPase activity
I0J99_RS15870	COG0395	ABC-type sugar transport system, permease component
I0J99_RS15885	COG2233	PERMEase
I0J99_RS15905	COG0803	Belongs to the bacterial solute-binding protein 9 family
I0J99_RS15910	COG1121	(ABC) transporter
I0J99_RS15915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0J99_RS15920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0J99_RS15940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I0J99_RS15945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I0J99_RS15950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I0J99_RS15955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I0J99_RS15960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I0J99_RS15975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I0J99_RS15995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0J99_RS16005	COG4974	Belongs to the 'phage' integrase family
I0J99_RS16020	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS16035	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0J99_RS16040	COG0567	Dehydrogenase, E1 component
I0J99_RS16045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0J99_RS16050	COG0045	succinate-CoA ligase (ADP-forming) activity
I0J99_RS16055	COG0039	L-malate dehydrogenase activity
I0J99_RS16060	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I0J99_RS16070	COG3549	Plasmid maintenance system killer
I0J99_RS16075	COG2845	Protein of unknown function (DUF459)
I0J99_RS16085	COG0395	ABC-type sugar transport system, permease component
I0J99_RS16090	COG1175	transmembrane transport
I0J99_RS16115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0J99_RS16135	COG2009	succinate dehydrogenase
I0J99_RS16160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I0J99_RS16165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I0J99_RS16170	COG0181	hydroxymethylbilane synthase activity
I0J99_RS16195	COG0519	Catalyzes the synthesis of GMP from XMP
I0J99_RS16195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I0J99_RS16210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I0J99_RS16225	COG1217	gtp-binding protein TYPA
I0J99_RS16235	COG4249	Peptidase C14 caspase catalytic subunit p20
I0J99_RS16240	COG0154	amidase activity
I0J99_RS16265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I0J99_RS16270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I0J99_RS16285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I0J99_RS16290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I0J99_RS16295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I0J99_RS16300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I0J99_RS16305	COG0799	negative regulation of ribosome biogenesis
I0J99_RS16310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I0J99_RS16320	COG0793	Belongs to the peptidase S41A family
I0J99_RS16325	COG2861	carbohydrate metabolic process
I0J99_RS16330	COG0494	nUDIX hydrolase
I0J99_RS16345	COG0587	DNA-directed DNA polymerase activity
I0J99_RS16380	COG0066	3-isopropylmalate dehydratase activity
I0J99_RS16385	COG0251	oxidation-reduction process
I0J99_RS16390	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I0J99_RS16400	COG0523	cobalamin synthesis protein
I0J99_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS16410	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS16415	COG1070	Carbohydrate kinase
I0J99_RS16420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0J99_RS16430	COG0022	dehydrogenase e1 component
I0J99_RS16435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0J99_RS16440	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS16445	COG1129	ABC transporter
I0J99_RS16470	COG3118	belongs to the thioredoxin family
I0J99_RS16475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I0J99_RS16480	COG2835	tetraacyldisaccharide 4'-kinase activity
I0J99_RS16485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0J99_RS16490	COG1946	Acyl-CoA thioesterase
I0J99_RS16495	COG0347	Belongs to the P(II) protein family
I0J99_RS16500	COG0004	ammonium transporteR
I0J99_RS16505	COG1674	ftsk spoiiie
I0J99_RS16510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I0J99_RS16525	COG0745	RESPONSE REGULATOR receiver
I0J99_RS16540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I0J99_RS16550	COG0477	Major facilitator Superfamily
I0J99_RS16555	COG0137	argininosuccinate synthase activity
I0J99_RS16570	COG4120	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS16580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I0J99_RS16595	COG2154	pterin-4-alpha-carbinolamine dehydratase
I0J99_RS16600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I0J99_RS16610	COG4181	ATPase activity
I0J99_RS16620	COG0670	Belongs to the BI1 family
I0J99_RS16630	COG0740	serine-type endopeptidase activity
I0J99_RS16640	COG0640	Transcriptional regulator
I0J99_RS16655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I0J99_RS16660	COG4133	protoheme IX ABC transporter activity
I0J99_RS16665	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0J99_RS16670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0J99_RS16690	COG2917	probably involved in intracellular septation
I0J99_RS16695	COG0552	protein localization to endoplasmic reticulum
I0J99_RS16700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0J99_RS16705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I0J99_RS16710	COG2161	toxin-antitoxin pair type II binding
I0J99_RS16720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I0J99_RS16725	COG0287	Prephenate dehydrogenase
I0J99_RS16725	COG1605	Chorismate mutase
I0J99_RS16730	COG0228	four-way junction DNA binding
I0J99_RS16735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I0J99_RS16740	COG0336	Belongs to the RNA methyltransferase TrmD family
I0J99_RS16750	COG0335	large ribosomal subunit rRNA binding
I0J99_RS16760	COG0765	amino acid transport
I0J99_RS16765	COG0488	(ABC) transporter
I0J99_RS16790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I0J99_RS16800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0J99_RS16805	COG1329	Transcriptional regulator
I0J99_RS16810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I0J99_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS16830	COG0183	Belongs to the thiolase family
I0J99_RS16835	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I0J99_RS16840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I0J99_RS16845	COG0625	glutathione transferase activity
I0J99_RS16850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0J99_RS16855	COG0142	geranyltranstransferase activity
I0J99_RS16860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0J99_RS16870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I0J99_RS16875	COG2223	nitrite transmembrane transporter activity
I0J99_RS16885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS16890	COG0765	amino acid transport
I0J99_RS16895	COG1126	abc transporter atp-binding protein
I0J99_RS16900	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I0J99_RS16910	COG1132	(ABC) transporter
I0J99_RS16925	COG3459	Glycosyltransferase 36 associated
I0J99_RS16940	COG5383	Protein conserved in bacteria
I0J99_RS16955	COG0436	Aminotransferase
I0J99_RS16965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0J99_RS16980	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS16990	COG3842	ATPase activity
I0J99_RS16995	COG0395	ABC-type sugar transport system, permease component
I0J99_RS17000	COG1175	transmembrane transport
I0J99_RS17005	COG1653	transport
I0J99_RS17010	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS17015	COG1024	Enoyl-CoA hydratase
I0J99_RS17025	COG0673	inositol 2-dehydrogenase activity
I0J99_RS17030	COG1609	Transcriptional regulator
I0J99_RS17040	COG0339	signal peptide processing
I0J99_RS17050	COG0473	3-isopropylmalate dehydrogenase activity
I0J99_RS17055	COG0671	phosphoesterase, PA-phosphatase related
I0J99_RS17075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0J99_RS17085	COG0288	reversible hydration of carbon dioxide
I0J99_RS17095	COG2902	Dehydrogenase
I0J99_RS17105	COG0138	bifunctional purine biosynthesis protein purh
I0J99_RS17120	COG0501	Belongs to the peptidase M48B family
I0J99_RS17130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0J99_RS17150	COG0495	leucyl-tRNA aminoacylation
I0J99_RS17175	COG0357	Ribosomal RNA small subunit methyltransferase G
I0J99_RS17180	COG0445	tRNA wobble uridine modification
I0J99_RS17185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I0J99_RS17190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I0J99_RS17195	COG1981	membrane
I0J99_RS17205	COG0437	4 iron, 4 sulfur cluster binding
I0J99_RS17210	COG2864	formate dehydrogenase
I0J99_RS17255	COG2204	response regulator
I0J99_RS17275	COG1305	Transglutaminase-like
I0J99_RS17300	COG0488	(ABC) transporter
I0J99_RS17305	COG0583	DNA-binding transcription factor activity
I0J99_RS17325	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS17350	COG2186	Transcriptional regulator
I0J99_RS17360	COG1802	Transcriptional regulator
I0J99_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS17390	COG1609	Transcriptional regulator
I0J99_RS17395	COG0765	amino acid transport
I0J99_RS17400	COG0765	amino acid transport
I0J99_RS17405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS17410	COG1126	abc transporter atp-binding protein
I0J99_RS17415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0J99_RS17425	COG0251	oxidation-reduction process
I0J99_RS17445	COG0583	DNA-binding transcription factor activity
I0J99_RS17450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I0J99_RS17455	COG0747	negative chemotaxis
I0J99_RS17460	COG0601	transmembrane transport
I0J99_RS17465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS17470	COG0444	Belongs to the ABC transporter superfamily
I0J99_RS17540	COG1278	Cold shock
I0J99_RS17550	COG3239	Fatty acid desaturase
I0J99_RS17570	COG0628	permease
I0J99_RS17575	COG3300	MHYT domain
I0J99_RS17575	COG5001	Diguanylate cyclase
I0J99_RS17585	COG1404	Belongs to the peptidase S8 family
I0J99_RS17610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I0J99_RS17615	COG0318	PFAM AMP-dependent synthetase and ligase
I0J99_RS17635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS17640	COG1802	Transcriptional regulator
I0J99_RS17645	COG4964	Belongs to the GSP D family
I0J99_RS17665	COG4106	trans-aconitate 2-methyltransferase activity
I0J99_RS17695	COG0583	DNA-binding transcription factor activity
I0J99_RS17705	COG1278	Cold shock
I0J99_RS17710	COG0477	Major facilitator Superfamily
I0J99_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS17755	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS17760	COG1129	ABC transporter
I0J99_RS17765	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS17770	COG4585	Histidine kinase
I0J99_RS17800	COG1129	ABC transporter
I0J99_RS17815	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS17820	COG1802	Transcriptional regulator
I0J99_RS17840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I0J99_RS17845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I0J99_RS17855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I0J99_RS17860	COG0129	dihydroxy-acid dehydratase activity
I0J99_RS17865	COG2084	Dehydrogenase
I0J99_RS17870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS17875	COG0277	FAD linked oxidase domain protein
I0J99_RS17880	COG2186	Transcriptional regulator
I0J99_RS17890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I0J99_RS17895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS17900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS17920	COG0657	acetylesterase activity
I0J99_RS17930	COG1454	alcohol dehydrogenase
I0J99_RS17935	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I0J99_RS17940	COG1802	Transcriptional regulator
I0J99_RS17945	COG1129	ABC transporter
I0J99_RS17950	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS17955	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS17960	COG0693	protein deglycase activity
I0J99_RS17985	COG4634	DNA integration
I0J99_RS18045	COG1086	Polysaccharide biosynthesis protein
I0J99_RS18050	COG0583	DNA-binding transcription factor activity
I0J99_RS18055	COG3177	Filamentation induced by cAMP protein fic
I0J99_RS18065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0J99_RS18070	COG2910	NAD(P)H-binding
I0J99_RS18075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0J99_RS18080	COG0702	epimerase
I0J99_RS18090	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS18105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS18120	COG0667	Aldo Keto reductase
I0J99_RS18140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I0J99_RS18155	COG3920	Histidine kinase
I0J99_RS18160	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I0J99_RS18215	COG1116	anion transmembrane transporter activity
I0J99_RS18225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0J99_RS18235	COG3550	peptidyl-serine autophosphorylation
I0J99_RS18290	COG3278	Belongs to the heme-copper respiratory oxidase family
I0J99_RS18305	COG2010	Cytochrome c
I0J99_RS18340	COG3047	cAMP biosynthetic process
I0J99_RS18340	COG2885	chlorophyll binding
I0J99_RS18390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I0J99_RS18405	COG0617	tRNA 3'-terminal CCA addition
I0J99_RS18405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I0J99_RS18405	COG0517	IMP dehydrogenase activity
I0J99_RS18415	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I0J99_RS18420	COG0406	alpha-ribazole phosphatase activity
I0J99_RS18425	COG3459	Glycosyltransferase 36 associated
I0J99_RS18435	COG4302	ethanolamine ammonia-lyase activity
I0J99_RS18460	COG0673	inositol 2-dehydrogenase activity
I0J99_RS18475	COG2204	response regulator
I0J99_RS18480	COG4566	intracellular signal transduction
I0J99_RS18485	COG4191	Histidine kinase
I0J99_RS18500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0J99_RS18505	COG0626	cystathionine gamma-synthase activity
I0J99_RS18635	COG2963	transposase activity
I0J99_RS18640	COG3436	PFAM IS66 Orf2 family protein
I0J99_RS18700	COG0628	permease
I0J99_RS18735	COG0531	amino acid
I0J99_RS18740	COG1982	Orn Lys Arg decarboxylase major
I0J99_RS18755	COG0531	amino acid
I0J99_RS18800	COG3734	2-keto-3-deoxy-galactonokinase
I0J99_RS18810	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS18815	COG1653	transport
I0J99_RS18820	COG1175	transmembrane transport
I0J99_RS18825	COG0395	ABC-type sugar transport system, permease component
I0J99_RS18830	COG3842	ATPase activity
I0J99_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS18885	COG1278	Cold shock
I0J99_RS18905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I0J99_RS18925	COG0583	DNA-binding transcription factor activity
I0J99_RS18930	COG4638	Rieske (2fe-2S)
I0J99_RS18995	COG2010	Cytochrome c
I0J99_RS19035	COG2267	carboxylic ester hydrolase activity
I0J99_RS19045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0J99_RS19050	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS19070	COG0395	ABC-type sugar transport system, permease component
I0J99_RS19075	COG3842	ATPase activity
I0J99_RS19150	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I0J99_RS19155	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I0J99_RS19165	COG1433	Dinitrogenase iron-molybdenum cofactor
I0J99_RS19175	COG3383	formate dehydrogenase (NAD+) activity
I0J99_RS19225	COG0175	sulfate reduction
I0J99_RS19230	COG2895	sulfate adenylyltransferase (ATP) activity
I0J99_RS19230	COG0529	Catalyzes the synthesis of activated sulfate
I0J99_RS19295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I0J99_RS19330	COG3012	SEC-C Motif Domain Protein
I0J99_RS19410	COG3505	Type IV secretory pathway VirD4
I0J99_RS19430	COG0668	transmembrane transport
I0J99_RS19460	COG4566	intracellular signal transduction
I0J99_RS19470	COG3119	arylsulfatase activity
I0J99_RS19480	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0J99_RS19485	COG2843	Capsule synthesis protein
I0J99_RS19495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS19500	COG0601	transmembrane transport
I0J99_RS19545	COG3916	Acyl-homoserine-lactone synthase
I0J99_RS19550	COG3547	Transposase (IS116 IS110 IS902 family)
I0J99_RS19565	COG3328	transposase activity
I0J99_RS19620	COG0583	DNA-binding transcription factor activity
I0J99_RS19625	COG0667	Aldo Keto reductase
I0J99_RS19645	COG0583	DNA-binding transcription factor activity
I0J99_RS19825	COG3005	denitrification pathway
I0J99_RS19850	COG4459	periplasmic nitrate reductase
I0J99_RS19860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0J99_RS19885	COG2151	metal-sulfur cluster biosynthetic enzyme
I0J99_RS19915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0J99_RS19930	COG0714	Associated with various cellular activities
I0J99_RS19935	COG3256	nitric oxide reductase
I0J99_RS19950	COG1845	cytochrome c oxidase, subunit III
I0J99_RS19970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I0J99_RS19980	COG0826	peptidase U32
I0J99_RS19985	COG0826	peptidase U32
I0J99_RS20005	COG1309	transcriptional regulator
I0J99_RS20010	COG2814	Major facilitator Superfamily
I0J99_RS20015	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I0J99_RS20020	COG2948	multi-organism process
I0J99_RS20025	COG3504	Conjugal transfer protein
I0J99_RS20030	COG3736	Type IV secretory pathway, component VirB8
I0J99_RS20040	COG3704	protein secretion by the type IV secretion system
I0J99_RS20055	COG3451	type IV secretory pathway VirB4
I0J99_RS20060	COG3702	type iv secretory pathway
I0J99_RS20065	COG3838	Conjugal transfer protein Trbc
I0J99_RS20100	COG0477	Major facilitator Superfamily
I0J99_RS20105	COG0024	Methionine aminopeptidase
I0J99_RS20115	COG5564	TIM-barrel signal transduction protein
I0J99_RS20135	COG1175	transmembrane transport
I0J99_RS20150	COG3842	ATPase activity
I0J99_RS20155	COG3842	ATPase activity
I0J99_RS20160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0J99_RS20170	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS20175	COG1082	Xylose isomerase domain protein TIM barrel
I0J99_RS20180	COG1082	Xylose isomerase domain protein TIM barrel
I0J99_RS20210	COG0395	ABC-type sugar transport system, permease component
I0J99_RS20215	COG1175	transmembrane transport
I0J99_RS20240	COG4608	Belongs to the ABC transporter superfamily
I0J99_RS20245	COG0444	Belongs to the ABC transporter superfamily
I0J99_RS20250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS20255	COG0601	transmembrane transport
I0J99_RS20265	COG0154	amidase activity
I0J99_RS20275	COG0747	negative chemotaxis
I0J99_RS20300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I0J99_RS20305	COG2086	electron transfer activity
I0J99_RS20325	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS20340	COG1024	Enoyl-CoA hydratase
I0J99_RS20350	COG0656	L-ascorbic acid biosynthetic process
I0J99_RS20375	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS20380	COG1063	alcohol dehydrogenase
I0J99_RS20385	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS20390	COG1129	ABC transporter
I0J99_RS20395	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS20405	COG1309	transcriptional regulator
I0J99_RS20410	COG1063	alcohol dehydrogenase
I0J99_RS20420	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS20425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS20430	COG0601	transmembrane transport
I0J99_RS20435	COG0747	negative chemotaxis
I0J99_RS20445	COG2186	Transcriptional regulator
I0J99_RS20455	COG0477	Major facilitator Superfamily
I0J99_RS20465	COG0183	Belongs to the thiolase family
I0J99_RS20495	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS20520	COG1335	isochorismatase
I0J99_RS20525	COG0006	proline dipeptidase activity
I0J99_RS20535	COG5598	trimethylamine methyltransferase
I0J99_RS20585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I0J99_RS20590	COG0625	glutathione transferase activity
I0J99_RS20610	COG1802	Transcriptional regulator
I0J99_RS20620	COG3845	ABC transporter
I0J99_RS20625	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS20630	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS20705	COG0651	ATP synthesis coupled electron transport
I0J99_RS20715	COG0651	ATP synthesis coupled electron transport
I0J99_RS20725	COG0839	Belongs to the complex I subunit 6 family
I0J99_RS20730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I0J99_RS20735	COG5001	Diguanylate cyclase
I0J99_RS20755	COG0840	transmembrane signaling receptor activity
I0J99_RS20760	COG0643	Histidine kinase
I0J99_RS20760	COG2198	Histidine kinase
I0J99_RS20795	COG0489	protein tyrosine kinase activity
I0J99_RS20820	COG3264	Mechanosensitive ion channel
I0J99_RS20820	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I0J99_RS20855	COG1672	PFAM Archaeal ATPase
I0J99_RS20855	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I0J99_RS20860	COG0723	plastoquinol--plastocyanin reductase activity
I0J99_RS20875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0J99_RS20875	COG4651	solute:proton antiporter activity
I0J99_RS20885	COG1902	pentaerythritol trinitrate reductase activity
I0J99_RS20905	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS20915	COG0583	DNA-binding transcription factor activity
I0J99_RS20950	COG2814	Major facilitator Superfamily
I0J99_RS20970	COG0444	Belongs to the ABC transporter superfamily
I0J99_RS20975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS20980	COG0601	transmembrane transport
I0J99_RS20995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0J99_RS21060	COG0628	permease
I0J99_RS21090	COG3119	arylsulfatase activity
I0J99_RS21095	COG4191	Histidine kinase
I0J99_RS21110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0J99_RS21170	COG2252	PERMEase
I0J99_RS21180	COG0583	DNA-binding transcription factor activity
I0J99_RS21185	COG1335	isochorismatase
I0J99_RS21195	COG1309	transcriptional regulator
I0J99_RS21225	COG1017	nitric oxide dioxygenase activity
I0J99_RS21225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I0J99_RS21230	COG0583	DNA-binding transcription factor activity
I0J99_RS21245	COG1120	ATPase activity
I0J99_RS21250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0J99_RS21255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0J99_RS21280	COG1177	transmembrane transport
I0J99_RS21285	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0J99_RS21290	COG3842	ATPase activity
I0J99_RS21300	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS21305	COG1802	Transcriptional regulator
I0J99_RS21315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0J99_RS21330	COG0346	lactoylglutathione lyase activity
I0J99_RS21370	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS21380	COG0583	DNA-binding transcription factor activity
I0J99_RS21385	COG3328	transposase activity
I0J99_RS21435	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I0J99_RS21440	COG2814	Major facilitator Superfamily
I0J99_RS21450	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I0J99_RS21460	COG1335	isochorismatase
I0J99_RS21470	COG2207	Transcriptional regulator
I0J99_RS21510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0J99_RS21520	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS21525	COG0473	3-isopropylmalate dehydrogenase activity
I0J99_RS21535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS21545	COG0454	-acetyltransferase
I0J99_RS21565	COG0601	transmembrane transport
I0J99_RS21570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS21580	COG1522	sequence-specific DNA binding
I0J99_RS21595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0J99_RS21620	COG3278	Belongs to the heme-copper respiratory oxidase family
I0J99_RS21630	COG0459	protein refolding
I0J99_RS21635	COG0156	8-amino-7-oxononanoate synthase activity
I0J99_RS21640	COG1999	signal sequence binding
I0J99_RS21665	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0J99_RS21710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0J99_RS21720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0J99_RS21730	COG1309	transcriptional regulator
I0J99_RS21770	COG1404	Belongs to the peptidase S8 family
I0J99_RS21940	COG2814	Major facilitator Superfamily
I0J99_RS21955	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I0J99_RS21965	COG0583	DNA-binding transcription factor activity
I0J99_RS21995	COG0235	Class ii aldolase
I0J99_RS22005	COG0583	DNA-binding transcription factor activity
I0J99_RS22025	COG0583	DNA-binding transcription factor activity
I0J99_RS22045	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS22050	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS22055	COG1129	ABC transporter
I0J99_RS22060	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS22070	COG1940	carbohydrate kinase activity
I0J99_RS22080	COG1309	transcriptional regulator
I0J99_RS22115	COG1846	Transcriptional regulator
I0J99_RS22135	COG1335	isochorismatase
I0J99_RS22170	COG4974	Belongs to the 'phage' integrase family
I0J99_RS22180	COG1278	Cold shock
I0J99_RS22200	COG1309	transcriptional regulator
I0J99_RS22210	COG4974	Belongs to the 'phage' integrase family
I0J99_RS22230	COG2267	carboxylic ester hydrolase activity
I0J99_RS22245	COG4638	Rieske (2fe-2S)
I0J99_RS22250	COG0583	DNA-binding transcription factor activity
I0J99_RS22265	COG2855	membrane
I0J99_RS22275	COG0477	Major facilitator Superfamily
I0J99_RS22285	COG1414	Transcriptional regulator
I0J99_RS22305	COG0251	oxidation-reduction process
I0J99_RS22335	COG2944	sequence-specific DNA binding
I0J99_RS22345	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I0J99_RS22350	COG0277	FAD linked oxidase domain protein
I0J99_RS22355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I0J99_RS22360	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS22390	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS22390	COG0604	alcohol dehydrogenase
I0J99_RS22390	COG3321	synthase
I0J99_RS22395	COG1063	alcohol dehydrogenase
I0J99_RS22400	COG1802	Transcriptional regulator
I0J99_RS22435	COG4221	oxidoreductase activity
I0J99_RS22450	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS22460	COG3938	Belongs to the proline racemase family
I0J99_RS22465	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS22470	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS22475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS22480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS22485	COG0765	amino acid transport
I0J99_RS22490	COG0765	amino acid transport
I0J99_RS22495	COG1126	abc transporter atp-binding protein
I0J99_RS22520	COG3609	addiction module antidote protein, CC2985 family
I0J99_RS22530	COG4974	Belongs to the 'phage' integrase family
I0J99_RS22540	COG3293	Transposase
I0J99_RS22570	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS22610	COG0431	NADPH-dependent FMN reductase
I0J99_RS22640	COG3237	CsbD-like
I0J99_RS22650	COG3344	reverse transcriptase
I0J99_RS22680	COG3920	Histidine kinase
I0J99_RS22685	COG4191	Histidine kinase
I0J99_RS22685	COG0784	Response regulator, receiver
I0J99_RS22700	COG1278	Cold shock
I0J99_RS22775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0J99_RS22780	COG0251	oxidation-reduction process
I0J99_RS22815	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS22820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS22825	COG0436	Aminotransferase
I0J99_RS22840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS22845	COG0765	amino acid transport
I0J99_RS22855	COG1126	abc transporter atp-binding protein
I0J99_RS22865	COG2186	Transcriptional regulator
I0J99_RS22960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I0J99_RS22965	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS22975	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS22980	COG0747	negative chemotaxis
I0J99_RS22985	COG0601	transmembrane transport
I0J99_RS22990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS23010	COG4166	transmembrane transport
I0J99_RS23015	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS23020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS23025	COG0601	transmembrane transport
I0J99_RS23070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I0J99_RS23080	COG3842	ATPase activity
I0J99_RS23105	COG2084	Dehydrogenase
I0J99_RS23110	COG3265	gluconokinase activity
I0J99_RS23115	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS23120	COG1063	alcohol dehydrogenase
I0J99_RS23125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0J99_RS23140	COG0765	amino acid transport
I0J99_RS23145	COG0765	amino acid transport
I0J99_RS23170	COG4215	(ABC) transporter
I0J99_RS23180	COG1126	abc transporter atp-binding protein
I0J99_RS23185	COG2423	ornithine cyclodeaminase activity
I0J99_RS23200	COG3328	transposase activity
I0J99_RS23220	COG3077	Addiction module antitoxin, RelB DinJ family
I0J99_RS23240	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS23245	COG1957	nucleoside hydrolase
I0J99_RS23255	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS23260	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS23265	COG3845	ABC transporter
I0J99_RS23270	COG1744	ABC transporter substrate-binding protein PnrA-like
I0J99_RS23280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I0J99_RS23285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I0J99_RS23315	COG1063	alcohol dehydrogenase
I0J99_RS23325	COG1177	transmembrane transport
I0J99_RS23340	COG3842	ATPase activity
I0J99_RS23345	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS23365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I0J99_RS23380	COG0346	lactoylglutathione lyase activity
I0J99_RS23385	COG0583	DNA-binding transcription factor activity
I0J99_RS23395	COG2199	diguanylate cyclase activity
I0J99_RS23395	COG2203	Gaf domain
I0J99_RS23395	COG2200	EAL domain
I0J99_RS23430	COG1335	isochorismatase
I0J99_RS23435	COG0583	DNA-binding transcription factor activity
I0J99_RS23440	COG0583	DNA-binding transcription factor activity
I0J99_RS23445	COG1741	Belongs to the pirin family
I0J99_RS23460	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0J99_RS23490	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS23500	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS23505	COG4221	oxidoreductase activity
I0J99_RS23525	COG4221	oxidoreductase activity
I0J99_RS23575	COG2986	histidine ammonia-lyase
I0J99_RS23580	COG0583	DNA-binding transcription factor activity
I0J99_RS23585	COG0747	negative chemotaxis
I0J99_RS23600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS23645	COG0583	DNA-binding transcription factor activity
I0J99_RS23670	COG0642	Histidine kinase
I0J99_RS23675	COG0745	RESPONSE REGULATOR receiver
I0J99_RS23680	COG0673	inositol 2-dehydrogenase activity
I0J99_RS23690	COG0667	Aldo Keto reductase
I0J99_RS23710	COG0604	alcohol dehydrogenase
I0J99_RS23720	COG0583	DNA-binding transcription factor activity
I0J99_RS23730	COG1063	alcohol dehydrogenase
I0J99_RS23735	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS23750	COG0583	DNA-binding transcription factor activity
I0J99_RS23770	COG1733	regulation of RNA biosynthetic process
I0J99_RS23785	COG4584	PFAM Integrase catalytic
I0J99_RS23835	COG1126	abc transporter atp-binding protein
I0J99_RS23840	COG0765	amino acid transport
I0J99_RS23845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS23850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I0J99_RS23855	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS23880	COG0765	amino acid transport
I0J99_RS23885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0J99_RS23930	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS24020	COG0419	ATPase involved in DNA repair
I0J99_RS24055	COG0583	DNA-binding transcription factor activity
I0J99_RS24060	COG0251	oxidation-reduction process
I0J99_RS24065	COG1902	pentaerythritol trinitrate reductase activity
I0J99_RS24075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0J99_RS24095	COG2203	Gaf domain
I0J99_RS24095	COG3706	GGDEF domain
I0J99_RS24095	COG5001	Diguanylate cyclase
I0J99_RS24095	COG4251	negative regulation of phosphorylation
I0J99_RS24115	COG0395	ABC-type sugar transport system, permease component
I0J99_RS24140	COG2188	Transcriptional regulator
I0J99_RS24145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0J99_RS24185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0J99_RS24195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0J99_RS24205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I0J99_RS24210	COG1920	GTP binding
I0J99_RS24215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I0J99_RS24220	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I0J99_RS24220	COG0778	Nitroreductase
I0J99_RS24250	COG0418	dihydroorotase activity
I0J99_RS24275	COG2205	protein histidine kinase activity
I0J99_RS24305	COG4221	oxidoreductase activity
I0J99_RS24320	COG2080	2 iron, 2 sulfur cluster binding
I0J99_RS24325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I0J99_RS24330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS24355	COG0730	response to heat
I0J99_RS24370	COG3845	ABC transporter
I0J99_RS24375	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS24380	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS24385	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS24395	COG2814	Major facilitator Superfamily
I0J99_RS24405	COG0583	DNA-binding transcription factor activity
I0J99_RS24415	COG1309	transcriptional regulator
I0J99_RS24435	COG1764	response to oxidative stress
I0J99_RS24440	COG1414	Transcriptional regulator
I0J99_RS24445	COG1475	DNA binding
I0J99_RS24450	COG1192	Involved in chromosome partitioning
I0J99_RS24480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0J99_RS24490	COG0625	glutathione transferase activity
I0J99_RS24500	COG0753	catalase activity
I0J99_RS24505	COG1793	dna ligase
I0J99_RS24510	COG0583	DNA-binding transcription factor activity
I0J99_RS24535	COG1609	Transcriptional regulator
I0J99_RS24540	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS24545	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS24560	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0J99_RS24565	COG0022	dehydrogenase e1 component
I0J99_RS24570	COG1522	sequence-specific DNA binding
I0J99_RS24585	COG1187	pseudouridine synthase activity
I0J99_RS24615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0J99_RS24630	COG1309	transcriptional regulator
I0J99_RS24635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I0J99_RS24640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS24645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS24650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I0J99_RS24665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0J99_RS24670	COG0697	spore germination
I0J99_RS24690	COG1414	Transcriptional regulator
I0J99_RS24695	COG1475	DNA binding
I0J99_RS24700	COG1192	Involved in chromosome partitioning
I0J99_RS24710	COG2188	Transcriptional regulator
I0J99_RS24715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I0J99_RS24745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0J99_RS24750	COG1120	ATPase activity
I0J99_RS24760	COG3328	transposase activity
I0J99_RS24775	COG3609	addiction module antidote protein, CC2985 family
I0J99_RS24805	COG3360	Dodecin
I0J99_RS24810	COG1115	amino acid carrier protein
I0J99_RS24820	COG2814	Major facilitator Superfamily
I0J99_RS24830	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS24845	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS24850	COG4585	Histidine kinase
I0J99_RS24855	COG2197	response regulator
I0J99_RS24910	COG3685	Protein conserved in bacteria
I0J99_RS24920	COG0392	lysyltransferase activity
I0J99_RS24930	COG0028	Belongs to the TPP enzyme family
I0J99_RS24955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0J99_RS24960	COG0579	oxidoreductase
I0J99_RS24965	COG3284	Transcriptional regulator
I0J99_RS24980	COG1802	Transcriptional regulator
I0J99_RS24995	COG0747	negative chemotaxis
I0J99_RS25000	COG0601	transmembrane transport
I0J99_RS25005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS25020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0J99_RS25025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I0J99_RS25040	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS25075	COG0583	DNA-binding transcription factor activity
I0J99_RS25080	COG3845	ABC transporter
I0J99_RS25085	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS25090	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS25110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I0J99_RS25120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS25120	COG2080	2 iron, 2 sulfur cluster binding
I0J99_RS25125	COG0523	cobalamin synthesis protein
I0J99_RS25130	COG2233	PERMEase
I0J99_RS25135	COG0163	prenyltransferase activity
I0J99_RS25160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS25170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS25175	COG0601	transmembrane transport
I0J99_RS25180	COG0747	negative chemotaxis
I0J99_RS25190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I0J99_RS25195	COG1454	alcohol dehydrogenase
I0J99_RS25205	COG3395	kinase activity
I0J99_RS25230	COG1609	Transcriptional regulator
I0J99_RS25235	COG1178	ABC-type Fe3 transport system permease component
I0J99_RS25240	COG3842	ATPase activity
I0J99_RS25315	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I0J99_RS25320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I0J99_RS25380	COG1116	anion transmembrane transporter activity
I0J99_RS25385	COG1131	(ABC) transporter
I0J99_RS25390	COG0842	Transport permease protein
I0J99_RS25395	COG3791	Glutathione-dependent formaldehyde-activating
I0J99_RS25415	COG4451	ribulose bisphosphate carboxylase, small
I0J99_RS25420	COG1850	ribulose-bisphosphate carboxylase activity
I0J99_RS25425	COG0191	fructose-bisphosphate aldolase activity
I0J99_RS25430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I0J99_RS25435	COG3954	Phosphoribulokinase
I0J99_RS25440	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I0J99_RS25445	COG0583	DNA-binding transcription factor activity
I0J99_RS25455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I0J99_RS25460	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I0J99_RS25465	COG0535	radical SAM domain protein
I0J99_RS25470	COG0535	radical SAM domain protein
I0J99_RS25480	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS25485	COG0583	DNA-binding transcription factor activity
I0J99_RS25495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0J99_RS25495	COG0785	Cytochrome C biogenesis protein
I0J99_RS25500	COG0300	oxidoreductase activity
I0J99_RS25530	COG0596	Alpha beta hydrolase
I0J99_RS25575	COG1609	Transcriptional regulator
I0J99_RS25580	COG2182	Extracellular solute-binding protein
I0J99_RS25585	COG1175	transmembrane transport
I0J99_RS25590	COG0395	ABC-type sugar transport system, permease component
I0J99_RS25600	COG3842	ATPase activity
I0J99_RS25620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS25645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS25660	COG1063	alcohol dehydrogenase
I0J99_RS25665	COG0673	inositol 2-dehydrogenase activity
I0J99_RS25680	COG1260	myo-inositol-1-phosphate synthase
I0J99_RS25720	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I0J99_RS25730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS25740	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I0J99_RS25760	COG0765	amino acid transport
I0J99_RS25770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS25775	COG3938	Belongs to the proline racemase family
I0J99_RS25785	COG3938	Belongs to the proline racemase family
I0J99_RS25790	COG1765	OsmC-like protein
I0J99_RS25810	COG3246	L-lysine catabolic process to acetate
I0J99_RS25820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0J99_RS25835	COG2072	flavoprotein involved in K transport
I0J99_RS25840	COG3842	ATPase activity
I0J99_RS25845	COG1177	transmembrane transport
I0J99_RS25875	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS25880	COG2233	PERMEase
I0J99_RS25885	COG1609	Transcriptional regulator
I0J99_RS25895	COG2358	TRAP transporter, solute receptor (TAXI family
I0J99_RS25910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS25915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS25915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I0J99_RS25920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS25925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS25930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS25940	COG2133	pyrroloquinoline quinone binding
I0J99_RS25960	COG2376	Dihydroxyacetone kinase
I0J99_RS25965	COG1461	Dihydroxyacetone kinase
I0J99_RS25970	COG2376	Dihydroxyacetone kinase
I0J99_RS25980	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS25985	COG1129	ABC transporter
I0J99_RS25990	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS26000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS26020	COG1609	Transcriptional regulator
I0J99_RS26025	COG1653	transport
I0J99_RS26040	COG3842	ATPase activity
I0J99_RS26050	COG0673	inositol 2-dehydrogenase activity
I0J99_RS26075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I0J99_RS26090	COG1309	transcriptional regulator
I0J99_RS26120	COG2010	Cytochrome c
I0J99_RS26120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS26130	COG2207	Transcriptional regulator
I0J99_RS26150	COG0287	Prephenate dehydrogenase
I0J99_RS26165	COG1129	ABC transporter
I0J99_RS26170	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS26175	COG0673	inositol 2-dehydrogenase activity
I0J99_RS26190	COG2205	protein histidine kinase activity
I0J99_RS26190	COG0784	Response regulator, receiver
I0J99_RS26225	COG3842	ATPase activity
I0J99_RS26235	COG1840	ABC-type Fe3 transport system, periplasmic component
I0J99_RS26240	COG1609	Transcriptional regulator
I0J99_RS26245	COG1309	transcriptional regulator
I0J99_RS26260	COG1136	(ABC) transporter
I0J99_RS26265	COG0698	ribose 5-phosphate isomerase
I0J99_RS26270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS26280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS26285	COG2186	Transcriptional regulator
I0J99_RS26305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0J99_RS26310	COG3842	ATPase activity
I0J99_RS26315	COG1177	transmembrane transport
I0J99_RS26320	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0J99_RS26350	COG0604	alcohol dehydrogenase
I0J99_RS26370	COG2186	Transcriptional regulator
I0J99_RS26375	COG1850	ribulose-bisphosphate carboxylase activity
I0J99_RS26385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS26390	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I0J99_RS26395	COG2080	2 iron, 2 sulfur cluster binding
I0J99_RS26420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS26420	COG2010	Cytochrome c
I0J99_RS26425	COG2080	2 iron, 2 sulfur cluster binding
I0J99_RS26430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS26430	COG2010	Cytochrome c
I0J99_RS26440	COG0145	ligase activity
I0J99_RS26445	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
I0J99_RS26450	COG4647	ligase activity
I0J99_RS26485	COG1653	transport
I0J99_RS26490	COG1175	transmembrane transport
I0J99_RS26495	COG0395	ABC-type sugar transport system, permease component
I0J99_RS26500	COG3842	ATPase activity
I0J99_RS26505	COG0625	glutathione transferase activity
I0J99_RS26510	COG1063	alcohol dehydrogenase
I0J99_RS26515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0J99_RS26520	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS26525	COG1522	sequence-specific DNA binding
I0J99_RS26530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0J99_RS26535	COG1126	abc transporter atp-binding protein
I0J99_RS26545	COG0765	amino acid transport
I0J99_RS26550	COG0765	amino acid transport
I0J99_RS26555	COG3473	Maleate cis-trans isomerase
I0J99_RS26560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0J99_RS26565	COG2423	ornithine cyclodeaminase activity
I0J99_RS26570	COG0006	proline dipeptidase activity
I0J99_RS26575	COG3608	succinylglutamate desuccinylase aspartoacylase
I0J99_RS26590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS26600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS26605	COG1063	alcohol dehydrogenase
I0J99_RS26610	COG1312	Catalyzes the dehydration of D-mannonate
I0J99_RS26615	COG3300	MHYT domain
I0J99_RS26615	COG5001	Diguanylate cyclase
I0J99_RS26655	COG1309	transcriptional regulator
I0J99_RS26660	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS26710	COG1363	Peptidase, m42
I0J99_RS26715	COG4585	Histidine kinase
I0J99_RS26740	COG2192	nodulation
I0J99_RS26760	COG0747	negative chemotaxis
I0J99_RS26765	COG0601	transmembrane transport
I0J99_RS26775	COG4608	Belongs to the ABC transporter superfamily
I0J99_RS26780	COG2188	Transcriptional regulator
I0J99_RS26785	COG0367	asparagine synthase
I0J99_RS26805	COG1129	ABC transporter
I0J99_RS26810	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS26830	COG0235	Class ii aldolase
I0J99_RS26850	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS26855	COG0583	DNA-binding transcription factor activity
I0J99_RS26870	COG1070	Carbohydrate kinase
I0J99_RS26880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I0J99_RS26885	COG0667	Aldo Keto reductase
I0J99_RS26895	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS26900	COG1129	ABC transporter
I0J99_RS26920	COG1129	ABC transporter
I0J99_RS26930	COG2186	Transcriptional regulator
I0J99_RS26935	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS26940	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS26960	COG2201	protein-glutamate methylesterase activity
I0J99_RS27000	COG3706	GGDEF domain
I0J99_RS27005	COG1309	transcriptional regulator
I0J99_RS27025	COG3220	belongs to the UPF0276 family
I0J99_RS27065	COG1609	Transcriptional regulator
I0J99_RS27120	COG2801	Transposase and inactivated derivatives
I0J99_RS27200	COG2832	Protein of unknown function (DUF454)
I0J99_RS27260	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I0J99_RS27270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I0J99_RS27270	COG0517	IMP dehydrogenase activity
I0J99_RS27290	COG1132	(ABC) transporter
I0J99_RS27330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I0J99_RS27340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0J99_RS27375	COG1215	transferase activity, transferring glycosyl groups
I0J99_RS27380	COG0562	UDP-galactopyranose mutase
I0J99_RS27490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0J99_RS27500	COG1091	dTDP-4-dehydrorhamnose reductase activity
I0J99_RS27505	COG1088	dTDP-glucose 4,6-dehydratase activity
I0J99_RS27510	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I0J99_RS27520	COG1596	polysaccharide export
I0J99_RS27525	COG2197	response regulator
I0J99_RS27530	COG2197	response regulator
I0J99_RS27535	COG2197	response regulator
I0J99_RS27555	COG1609	Transcriptional regulator
I0J99_RS27575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I0J99_RS27595	COG0275	rRNA processing
I0J99_RS27710	COG3436	PFAM IS66 Orf2 family protein
I0J99_RS27725	COG3328	transposase activity
I0J99_RS27760	COG1696	Membrane protein involved in D-alanine export
I0J99_RS27770	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS27770	COG3347	Dehydrogenase
I0J99_RS27785	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS27800	COG1070	Carbohydrate kinase
I0J99_RS27855	COG0601	transmembrane transport
I0J99_RS27860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS27865	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS27870	COG2843	Capsule synthesis protein
I0J99_RS27875	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0J99_RS27885	COG3285	dna ligase
I0J99_RS27885	COG1793	dna ligase
I0J99_RS27905	COG1525	nuclease
I0J99_RS27940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0J99_RS27960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I0J99_RS27975	COG0456	acetyltransferase
I0J99_RS27985	COG0165	Argininosuccinate lyase
I0J99_RS28005	COG2079	MmgE PrpD family protein
I0J99_RS28020	COG1414	Transcriptional regulator
I0J99_RS28035	COG0395	ABC-type sugar transport system, permease component
I0J99_RS28040	COG3842	ATPase activity
I0J99_RS28045	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS28050	COG3254	rhamnose metabolic process
I0J99_RS28065	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS28070	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0J99_RS28075	COG4948	Mandelate Racemase Muconate Lactonizing
I0J99_RS28080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0J99_RS28085	COG3707	response regulator
I0J99_RS28095	COG1396	sequence-specific DNA binding
I0J99_RS28100	COG3265	gluconokinase activity
I0J99_RS28105	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS28110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I0J99_RS28145	COG0277	FAD linked oxidase domain protein
I0J99_RS28150	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I0J99_RS28155	COG4208	sulfate ABC transporter
I0J99_RS28165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I0J99_RS28180	COG0765	amino acid transport
I0J99_RS28185	COG0765	amino acid transport
I0J99_RS28195	COG0251	oxidation-reduction process
I0J99_RS28205	COG3842	ATPase activity
I0J99_RS28210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0J99_RS28235	COG1846	Transcriptional regulator
I0J99_RS28235	COG1940	carbohydrate kinase activity
I0J99_RS28240	COG0175	sulfate reduction
I0J99_RS28245	COG0529	Catalyzes the synthesis of activated sulfate
I0J99_RS28245	COG2895	sulfate adenylyltransferase (ATP) activity
I0J99_RS28260	COG1181	Belongs to the D-alanine--D-alanine ligase family
I0J99_RS28265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS28290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0J99_RS28320	COG0297	glycogen (starch) synthase activity
I0J99_RS28335	COG1596	polysaccharide export
I0J99_RS28340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0J99_RS28350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0J99_RS28360	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS28365	COG0668	transmembrane transport
I0J99_RS28410	COG0747	negative chemotaxis
I0J99_RS28415	COG0601	transmembrane transport
I0J99_RS28420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS28445	COG1132	(ABC) transporter
I0J99_RS28450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0J99_RS28450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0J99_RS28460	COG1609	Transcriptional regulator
I0J99_RS28470	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0J99_RS28475	COG1177	transmembrane transport
I0J99_RS28480	COG3842	ATPase activity
I0J99_RS28490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I0J99_RS28495	COG1473	amidohydrolase
I0J99_RS28500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I0J99_RS28505	COG2252	PERMEase
I0J99_RS28515	COG4266	Belongs to the allantoicase family
I0J99_RS28520	COG3648	Uricase
I0J99_RS28520	COG3195	allantoin biosynthetic process
I0J99_RS28525	COG2351	hydroxyisourate hydrolase activity
I0J99_RS28535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS28545	COG1733	regulation of RNA biosynthetic process
I0J99_RS28565	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS28570	COG0071	Belongs to the small heat shock protein (HSP20) family
I0J99_RS28575	COG0071	Belongs to the small heat shock protein (HSP20) family
I0J99_RS28585	COG4953	penicillin-binding protein 1C
I0J99_RS28595	COG1349	DNA-binding transcription factor activity
I0J99_RS28600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I0J99_RS28605	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS28625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0J99_RS28630	COG1732	Glycine betaine
I0J99_RS28635	COG1174	glycine betaine transport
I0J99_RS28640	COG1125	glycine betaine transport
I0J99_RS28645	COG1174	glycine betaine transport
I0J99_RS28650	COG0673	inositol 2-dehydrogenase activity
I0J99_RS28660	COG0395	ABC-type sugar transport system, permease component
I0J99_RS28670	COG3842	ATPase activity
I0J99_RS28695	COG0251	oxidation-reduction process
I0J99_RS28700	COG1737	Transcriptional regulator
I0J99_RS28725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I0J99_RS28735	COG2986	histidine ammonia-lyase
I0J99_RS28740	COG1228	amidohydrolase
I0J99_RS28745	COG3344	reverse transcriptase
I0J99_RS28750	COG2814	Major facilitator Superfamily
I0J99_RS28755	COG0640	Transcriptional regulator
I0J99_RS28760	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I0J99_RS28765	COG3454	Phosphonate metabolism
I0J99_RS28770	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I0J99_RS28775	COG3639	organic phosphonate transmembrane transporter activity
I0J99_RS28780	COG3639	organic phosphonate transmembrane transporter activity
I0J99_RS28790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I0J99_RS28810	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS28820	COG0326	Molecular chaperone. Has ATPase activity
I0J99_RS28825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I0J99_RS28830	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS28835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0J99_RS28845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I0J99_RS28845	COG2755	lipolytic protein G-D-S-L family
I0J99_RS28850	COG1216	Glycosyl transferase, family 2
I0J99_RS28860	COG1132	(ABC) transporter
I0J99_RS28870	COG4166	transmembrane transport
I0J99_RS28875	COG0601	transmembrane transport
I0J99_RS28880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS28885	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS28900	COG0346	lactoylglutathione lyase activity
I0J99_RS28915	COG0842	Transport permease protein
I0J99_RS28920	COG0842	Transport permease protein
I0J99_RS28925	COG1131	(ABC) transporter
I0J99_RS28930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS28940	COG2205	protein histidine kinase activity
I0J99_RS28945	COG0745	RESPONSE REGULATOR receiver
I0J99_RS28950	COG2194	sulfuric ester hydrolase activity
I0J99_RS28960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I0J99_RS28965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0J99_RS28995	COG0297	glycogen (starch) synthase activity
I0J99_RS29015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS29025	COG1846	Transcriptional regulator
I0J99_RS29065	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I0J99_RS29075	COG1091	dTDP-4-dehydrorhamnose reductase activity
I0J99_RS29090	COG3237	CsbD-like
I0J99_RS29115	COG0628	permease
I0J99_RS29125	COG2080	2 iron, 2 sulfur cluster binding
I0J99_RS29130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I0J99_RS29135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS29145	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS29150	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS29155	COG1129	ABC transporter
I0J99_RS29160	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS29165	COG1609	Transcriptional regulator
I0J99_RS29175	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS29180	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I0J99_RS29185	COG2186	Transcriptional regulator
I0J99_RS29200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS29205	COG1904	glucuronate isomerase
I0J99_RS29210	COG0673	inositol 2-dehydrogenase activity
I0J99_RS29215	COG1295	ribonuclease BN
I0J99_RS29230	COG0583	DNA-binding transcription factor activity
I0J99_RS29240	COG2323	membrane
I0J99_RS29245	COG1295	ribonuclease BN
I0J99_RS29270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0J99_RS29270	COG2010	Cytochrome c
I0J99_RS29280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0J99_RS29290	COG1609	Transcriptional regulator
I0J99_RS29295	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
I0J99_RS29300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0J99_RS29305	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS29310	COG1129	ABC transporter
I0J99_RS29315	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS29330	COG3485	protocatechuate 3,4-dioxygenase
I0J99_RS29345	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS29350	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I0J99_RS29355	COG2207	Transcriptional regulator
I0J99_RS29360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0J99_RS29365	COG4521	taurine ABC transporter
I0J99_RS29370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I0J99_RS29375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0J99_RS29390	COG0028	Belongs to the TPP enzyme family
I0J99_RS29395	COG2855	membrane
I0J99_RS29405	COG1349	DNA-binding transcription factor activity
I0J99_RS29425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I0J99_RS29435	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS29445	COG1840	ABC-type Fe3 transport system, periplasmic component
I0J99_RS29450	COG3842	ATPase activity
I0J99_RS29475	COG3275	phosphorelay sensor kinase activity
I0J99_RS29490	COG2897	thiosulfate sulfurtransferase activity
I0J99_RS29520	COG0475	glutathione-regulated potassium exporter activity
I0J99_RS29520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0J99_RS29525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS29530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I0J99_RS29535	COG2080	2 iron, 2 sulfur cluster binding
I0J99_RS29545	COG2205	protein histidine kinase activity
I0J99_RS29570	COG0459	protein refolding
I0J99_RS29575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I0J99_RS29580	COG5425	PFAM Usg family protein
I0J99_RS29590	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0J99_RS29590	COG1902	pentaerythritol trinitrate reductase activity
I0J99_RS29610	COG3850	Histidine kinase
I0J99_RS29610	COG0642	Histidine kinase
I0J99_RS29620	COG0640	Transcriptional regulator
I0J99_RS29635	COG2217	Heavy metal translocating P-type atpase
I0J99_RS29640	COG0789	Transcriptional regulator
I0J99_RS29645	COG1238	metal cluster binding
I0J99_RS29675	COG0189	ligase activity
I0J99_RS29680	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS29685	COG1129	ABC transporter
I0J99_RS29690	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS29695	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS29700	COG2186	Transcriptional regulator
I0J99_RS29715	COG1175	transmembrane transport
I0J99_RS29720	COG1653	transport
I0J99_RS29730	COG0673	inositol 2-dehydrogenase activity
I0J99_RS29735	COG1609	Transcriptional regulator
I0J99_RS29755	COG0395	ABC-type sugar transport system, permease component
I0J99_RS29760	COG1175	transmembrane transport
I0J99_RS29765	COG2182	Extracellular solute-binding protein
I0J99_RS29780	COG0750	zinc metalloprotease
I0J99_RS29795	COG3409	Peptidoglycan-binding domain 1 protein
I0J99_RS29795	COG0793	Belongs to the peptidase S41A family
I0J99_RS29800	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS29815	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I0J99_RS29815	COG2273	Hydrolase Family 16
I0J99_RS29820	COG3920	Histidine kinase
I0J99_RS29820	COG2202	Pas domain
I0J99_RS29825	COG0784	Response regulator, receiver
I0J99_RS29840	COG0602	queuosine metabolic process
I0J99_RS29845	COG0720	synthase
I0J99_RS29850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I0J99_RS29855	COG5265	(ABC) transporter
I0J99_RS29860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0J99_RS29865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I0J99_RS29870	COG3307	-O-antigen
I0J99_RS29875	COG1596	polysaccharide export
I0J99_RS29880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0J99_RS29890	COG1215	transferase activity, transferring glycosyl groups
I0J99_RS29895	COG2327	Polysaccharide pyruvyl transferase
I0J99_RS29900	COG0463	Glycosyl transferase, family 2
I0J99_RS29905	COG2244	polysaccharide biosynthetic process
I0J99_RS29910	COG1525	nuclease
I0J99_RS29920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I0J99_RS29925	COG2273	Hydrolase Family 16
I0J99_RS29930	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS29935	COG1215	transferase activity, transferring glycosyl groups
I0J99_RS29940	COG1215	transferase activity, transferring glycosyl groups
I0J99_RS29945	COG1215	transferase activity, transferring glycosyl groups
I0J99_RS29950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0J99_RS29955	COG3206	protein involved in exopolysaccharide biosynthesis
I0J99_RS29955	COG0489	protein tyrosine kinase activity
I0J99_RS29965	COG0351	phosphomethylpyrimidine kinase
I0J99_RS29970	COG0450	alkyl hydroperoxide reductase
I0J99_RS29985	COG1609	Transcriptional regulator
I0J99_RS29995	COG0395	ABC-type sugar transport system, permease component
I0J99_RS30000	COG1175	transmembrane transport
I0J99_RS30010	COG3842	ATPase activity
I0J99_RS30015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0J99_RS30025	COG0765	amino acid transport
I0J99_RS30035	COG1609	Transcriptional regulator
I0J99_RS30045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS30055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS30060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0J99_RS30070	COG0243	molybdopterin cofactor binding
I0J99_RS30075	COG1648	precorrin-2 dehydrogenase activity
I0J99_RS30075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I0J99_RS30085	COG0330	HflC and HflK could
I0J99_RS30110	COG1959	2 iron, 2 sulfur cluster binding
I0J99_RS30115	COG1160	GTP binding
I0J99_RS30135	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I0J99_RS30140	COG0477	Major facilitator Superfamily
I0J99_RS30150	COG0024	Methionine aminopeptidase
I0J99_RS30185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I0J99_RS30190	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS30200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I0J99_RS30205	COG0583	DNA-binding transcription factor activity
I0J99_RS30215	COG0402	S-adenosylhomocysteine deaminase activity
I0J99_RS30225	COG2390	Transcriptional regulator
I0J99_RS30230	COG1069	ribulokinase activity
I0J99_RS30235	COG1063	alcohol dehydrogenase
I0J99_RS30240	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS30245	COG1129	ABC transporter
I0J99_RS30250	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS30255	COG2140	Oxalate decarboxylase
I0J99_RS30260	COG1304	FMN binding
I0J99_RS30295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0J99_RS30300	COG4191	Histidine kinase
I0J99_RS30305	COG4566	intracellular signal transduction
I0J99_RS30310	COG4566	intracellular signal transduction
I0J99_RS30315	COG0583	DNA-binding transcription factor activity
I0J99_RS30320	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS30325	COG2351	hydroxyisourate hydrolase activity
I0J99_RS30330	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I0J99_RS30335	COG3195	allantoin biosynthetic process
I0J99_RS30335	COG3648	Uricase
I0J99_RS30355	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I0J99_RS30355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0J99_RS30365	COG0513	Belongs to the DEAD box helicase family
I0J99_RS30395	COG2308	Evidence 4 Homologs of previously reported genes of
I0J99_RS30405	COG1305	Transglutaminase-like
I0J99_RS30415	COG0129	dihydroxy-acid dehydratase activity
I0J99_RS30420	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS30430	COG4214	carbohydrate transport
I0J99_RS30440	COG4213	ABC transporter substrate-binding protein
I0J99_RS30460	COG0673	inositol 2-dehydrogenase activity
I0J99_RS30475	COG4213	ABC transporter substrate-binding protein
I0J99_RS30480	COG4214	carbohydrate transport
I0J99_RS30485	COG1129	ABC transporter
I0J99_RS30590	COG3415	Transposase
I0J99_RS30590	COG2801	Transposase and inactivated derivatives
I0J99_RS30595	COG3547	Transposase (IS116 IS110 IS902 family)
I0J99_RS30645	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I0J99_RS30665	COG3189	MarR family transcriptional regulator
I0J99_RS30670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I0J99_RS30685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I0J99_RS30715	COG1129	ABC transporter
I0J99_RS30720	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS30750	COG1120	ATPase activity
I0J99_RS30755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0J99_RS30765	COG2226	methyltransferase
I0J99_RS30770	COG0583	DNA-binding transcription factor activity
I0J99_RS30780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I0J99_RS30785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I0J99_RS30790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I0J99_RS30835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I0J99_RS30840	COG1573	uracil-dna glycosylase
I0J99_RS30865	COG4974	Belongs to the 'phage' integrase family
I0J99_RS30870	COG0517	IMP dehydrogenase activity
I0J99_RS30905	COG3842	ATPase activity
I0J99_RS30910	COG1653	transport
I0J99_RS30915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I0J99_RS30915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I0J99_RS30920	COG1486	melibiose metabolic process
I0J99_RS30925	COG2188	Transcriptional regulator
I0J99_RS30930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I0J99_RS30935	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
I0J99_RS30975	COG0300	oxidoreductase activity
I0J99_RS31000	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I0J99_RS31030	COG0477	Major facilitator Superfamily
I0J99_RS31040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0J99_RS31045	COG1845	cytochrome c oxidase, subunit III
I0J99_RS31050	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I0J99_RS31055	COG3346	SURF1 family
I0J99_RS31125	COG0438	transferase activity, transferring glycosyl groups
I0J99_RS31130	COG0297	glycogen (starch) synthase activity
I0J99_RS31150	COG1280	lysine exporter protein (LysE YggA)
I0J99_RS31155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0J99_RS31175	COG2890	protein-(glutamine-N5) methyltransferase activity
I0J99_RS31185	COG1388	LysM domain
I0J99_RS31185	COG1376	ErfK ybiS ycfS ynhG family protein
I0J99_RS31200	COG4585	Histidine kinase
I0J99_RS31205	COG2197	response regulator
I0J99_RS31215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I0J99_RS31220	COG2894	cell division
I0J99_RS31225	COG0850	regulation of cytokinetic process
I0J99_RS31245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I0J99_RS31250	COG0318	PFAM AMP-dependent synthetase and ligase
I0J99_RS31260	COG0367	asparagine synthase
I0J99_RS31275	COG0667	Aldo Keto reductase
I0J99_RS31285	COG0395	ABC-type sugar transport system, permease component
I0J99_RS31290	COG1175	transmembrane transport
I0J99_RS31300	COG3842	ATPase activity
I0J99_RS31310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0J99_RS31320	COG3328	transposase activity
I0J99_RS31325	COG0235	Class ii aldolase
I0J99_RS31330	COG1609	Transcriptional regulator
I0J99_RS31335	COG2084	Dehydrogenase
I0J99_RS31340	COG3622	Belongs to the hyi family
I0J99_RS31345	COG3395	kinase activity
I0J99_RS31350	COG1879	ABC-type sugar transport system periplasmic component
I0J99_RS31355	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS31380	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I0J99_RS31390	COG2084	Dehydrogenase
I0J99_RS31395	COG3622	Belongs to the hyi family
I0J99_RS31400	COG3960	tartronate-semialdehyde synthase activity
I0J99_RS31405	COG1414	Transcriptional regulator
I0J99_RS31410	COG0583	DNA-binding transcription factor activity
I0J99_RS31415	COG3257	ureidoglycine aminohydrolase activity
I0J99_RS31425	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I0J99_RS31455	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS31475	COG4187	Peptidase family M20/M25/M40
I0J99_RS31510	COG0297	glycogen (starch) synthase activity
I0J99_RS31530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0J99_RS31535	COG2094	Belongs to the DNA glycosylase MPG family
I0J99_RS31540	COG2084	Dehydrogenase
I0J99_RS31555	COG1129	ABC transporter
I0J99_RS31560	COG4211	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS31575	COG1609	Transcriptional regulator
I0J99_RS31580	COG1129	ABC transporter
I0J99_RS31585	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS31645	COG0174	glutamine synthetase
I0J99_RS31655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0J99_RS31660	COG1215	transferase activity, transferring glycosyl groups
I0J99_RS31665	COG0246	Mannitol dehydrogenase
I0J99_RS31670	COG1028	Short-chain dehydrogenase reductase Sdr
I0J99_RS31680	COG1024	Enoyl-CoA hydratase
I0J99_RS31685	COG1960	acyl-CoA dehydrogenase activity
I0J99_RS31690	COG1396	sequence-specific DNA binding
I0J99_RS31690	COG3800	Transcriptional regulator
I0J99_RS31695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I0J99_RS31700	COG4770	biotin carboxylase activity
I0J99_RS31705	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I0J99_RS31705	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I0J99_RS31710	COG2188	Transcriptional regulator
I0J99_RS31715	COG3624	Phosphonate C-P lyase system protein PhnG
I0J99_RS31720	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I0J99_RS31725	COG3626	phosphonate metabolism
I0J99_RS31730	COG3627	carbon phosphorus lyase activity
I0J99_RS31735	COG4107	phosphonate C-P lyase system protein PhnK
I0J99_RS31740	COG4778	phosphonate C-P lyase system protein PhnL
I0J99_RS31750	COG2376	Dihydroxyacetone kinase
I0J99_RS31775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I0J99_RS31780	COG1802	Transcriptional regulator
I0J99_RS31810	COG0411	ABC transporter
I0J99_RS31815	COG0559	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS31825	COG0683	leucine binding
I0J99_RS31835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0J99_RS31840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0J99_RS31845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0J99_RS31865	COG3485	protocatechuate 3,4-dioxygenase
I0J99_RS31870	COG3485	protocatechuate 3,4-dioxygenase
I0J99_RS31875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0J99_RS31880	COG2267	carboxylic ester hydrolase activity
I0J99_RS31885	COG0583	DNA-binding transcription factor activity
I0J99_RS31905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I0J99_RS31915	COG1414	Transcriptional regulator
I0J99_RS31920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I0J99_RS31925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0J99_RS31930	COG0183	Belongs to the thiolase family
I0J99_RS31935	COG1254	Belongs to the acylphosphatase family
I0J99_RS31940	COG1595	DNA-templated transcription, initiation
I0J99_RS31965	COG1192	Involved in chromosome partitioning
I0J99_RS31970	COG1475	DNA binding
I0J99_RS31985	COG0411	ABC transporter
I0J99_RS32020	COG0784	Response regulator, receiver
I0J99_RS32020	COG2198	Histidine kinase
I0J99_RS32020	COG5002	protein histidine kinase activity
I0J99_RS32030	COG1301	dicarboxylic acid transport
I0J99_RS32035	COG4191	Histidine kinase
I0J99_RS32040	COG2204	response regulator
I0J99_RS32050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I0J99_RS32065	COG2022	thiamine diphosphate biosynthetic process
I0J99_RS32075	COG2390	Transcriptional regulator
I0J99_RS32085	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0J99_RS32090	COG1129	ABC transporter
I0J99_RS32100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I0J99_RS32105	COG2814	Major facilitator Superfamily
I0J99_RS32120	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I0J99_RS32140	COG0395	ABC-type sugar transport system, permease component
I0J99_RS32145	COG1175	transmembrane transport
I0J99_RS32170	COG0019	diaminopimelate decarboxylase activity
I0J99_RS32175	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0J99_RS32175	COG1024	Enoyl-CoA hydratase
I0J99_RS32180	COG1024	Enoyl-CoA hydratase
I0J99_RS32185	COG1607	acyl-coa hydrolase
I0J99_RS32190	COG2030	dehydratase
I0J99_RS32190	COG1012	belongs to the aldehyde dehydrogenase family
I0J99_RS32195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I0J99_RS32200	COG2151	metal-sulfur cluster biosynthetic enzyme
I0J99_RS32205	COG3396	Phenylacetate-CoA oxygenase
I0J99_RS32210	COG3460	Phenylacetate-CoA oxygenase
I0J99_RS32215	COG3396	Phenylacetate-CoA oxygenase
I0J99_RS32230	COG1486	melibiose metabolic process
I0J99_RS32235	COG4172	Belongs to the ABC transporter superfamily
I0J99_RS32240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0J99_RS32245	COG0601	transmembrane transport
I0J99_RS32250	COG0747	negative chemotaxis
I0J99_RS32255	COG1486	melibiose metabolic process