locus-tag	class	description
SPH21_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPH21_RS00015	COG0071	Belongs to the small heat shock protein (HSP20) family
SPH21_RS00025	COG0316	Belongs to the HesB IscA family
SPH21_RS00030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPH21_RS00035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPH21_RS00040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SPH21_RS00050	COG0416	fatty acid biosynthetic process
SPH21_RS00055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPH21_RS00060	COG0511	ligase activity, forming carbon-carbon bonds
SPH21_RS00065	COG0439	Biotin carboxylase
SPH21_RS00070	COG0805	protein transport
SPH21_RS00085	COG1139	Iron-sulfur cluster binding protein
SPH21_RS00095	COG1960	acyl-CoA dehydrogenase activity
SPH21_RS00100	COG0183	Belongs to the thiolase family
SPH21_RS00105	COG1024	Enoyl-CoA hydratase
SPH21_RS00105	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPH21_RS00120	COG1022	Amp-dependent synthetase and ligase
SPH21_RS00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS00140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPH21_RS00155	COG0386	Belongs to the glutathione peroxidase family
SPH21_RS00190	COG4935	Belongs to the peptidase S8 family
SPH21_RS00190	COG2234	aminopeptidase activity
SPH21_RS00195	COG1381	Involved in DNA repair and RecF pathway recombination
SPH21_RS00200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPH21_RS00210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPH21_RS00215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SPH21_RS00220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPH21_RS00230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SPH21_RS00240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPH21_RS00245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPH21_RS00250	COG0156	8-amino-7-oxononanoate synthase activity
SPH21_RS00255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SPH21_RS00270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPH21_RS00275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPH21_RS00280	COG0772	Belongs to the SEDS family
SPH21_RS00285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPH21_RS00290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPH21_RS00295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPH21_RS00300	COG0768	penicillin binding
SPH21_RS00310	COG0275	rRNA processing
SPH21_RS00315	COG2001	Belongs to the MraZ family
SPH21_RS00325	COG0126	phosphoglycerate kinase activity
SPH21_RS00335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPH21_RS00370	COG0563	adenylate kinase activity
SPH21_RS00375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPH21_RS00405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPH21_RS00445	COG4771	TonB-dependent receptor
SPH21_RS00505	COG2217	Heavy metal translocating P-type atpase
SPH21_RS00525	COG0708	Exodeoxyribonuclease III
SPH21_RS00540	COG4771	TonB-dependent receptor
SPH21_RS00550	COG2814	Major facilitator Superfamily
SPH21_RS00560	COG1940	carbohydrate kinase activity
SPH21_RS00595	COG1073	alpha beta
SPH21_RS00625	COG0667	Aldo Keto reductase
SPH21_RS00630	COG0656	L-ascorbic acid biosynthetic process
SPH21_RS00640	COG3275	phosphorelay sensor kinase activity
SPH21_RS00645	COG3279	Response regulator of the LytR AlgR family
SPH21_RS00675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SPH21_RS00705	COG0314	molybdopterin synthase activity
SPH21_RS00740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPH21_RS00745	COG4771	TonB-dependent receptor
SPH21_RS00775	COG4804	nuclease activity
SPH21_RS00790	COG4372	Transposase
SPH21_RS00865	COG1408	metallophosphoesterase
SPH21_RS00875	COG0038	chloride channel
SPH21_RS00920	COG2910	NAD(P)H-binding
SPH21_RS00950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPH21_RS00955	COG4206	TonB-dependent receptor
SPH21_RS00955	COG1629	transport
SPH21_RS00980	COG1609	Transcriptional regulator
SPH21_RS00990	COG0431	NADPH-dependent FMN reductase
SPH21_RS01005	COG1115	amino acid carrier protein
SPH21_RS01040	COG0673	inositol 2-dehydrogenase activity
SPH21_RS01050	COG2169	Transcriptional regulator
SPH21_RS01070	COG2354	Protein conserved in bacteria
SPH21_RS01095	COG1230	cation diffusion facilitator family transporter
SPH21_RS01125	COG2072	flavoprotein involved in K transport
SPH21_RS01130	COG0798	PFAM Bile acid sodium symporter
SPH21_RS01135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPH21_RS01140	COG1247	-acetyltransferase
SPH21_RS01270	COG3275	phosphorelay sensor kinase activity
SPH21_RS01280	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SPH21_RS01280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPH21_RS01295	COG4771	TonB-dependent receptor
SPH21_RS01305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS01365	COG0596	Alpha beta hydrolase
SPH21_RS01370	COG2217	Heavy metal translocating P-type atpase
SPH21_RS01375	COG2132	Multicopper oxidase
SPH21_RS01405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPH21_RS01410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPH21_RS01465	COG1733	regulation of RNA biosynthetic process
SPH21_RS01470	COG0659	secondary active sulfate transmembrane transporter activity
SPH21_RS01480	COG4974	Belongs to the 'phage' integrase family
SPH21_RS01510	COG4974	Belongs to the 'phage' integrase family
SPH21_RS01550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPH21_RS01555	COG1321	iron dependent repressor
SPH21_RS01560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPH21_RS01565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SPH21_RS01575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPH21_RS01580	COG2363	Small membrane protein
SPH21_RS01590	COG1214	PFAM Peptidase M22, glycoprotease
SPH21_RS01595	COG0594	ribonuclease P activity
SPH21_RS01600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SPH21_RS01610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SPH21_RS01615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPH21_RS01615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPH21_RS01630	COG0505	Belongs to the CarA family
SPH21_RS01635	COG0148	phosphopyruvate hydratase activity
SPH21_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS01650	COG1607	acyl-coa hydrolase
SPH21_RS01655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPH21_RS01655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPH21_RS01670	COG3385	transposase activity
SPH21_RS01680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SPH21_RS01690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPH21_RS01700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPH21_RS01705	COG1663	tetraacyldisaccharide 4'-kinase activity
SPH21_RS01760	COG0693	protein deglycase activity
SPH21_RS01785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPH21_RS01820	COG1160	GTP binding
SPH21_RS01825	COG1609	Transcriptional regulator
SPH21_RS01835	COG0673	inositol 2-dehydrogenase activity
SPH21_RS01855	COG0793	Belongs to the peptidase S41A family
SPH21_RS01880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SPH21_RS01890	COG1764	response to oxidative stress
SPH21_RS01895	COG1629	transport
SPH21_RS01905	COG3118	belongs to the thioredoxin family
SPH21_RS01915	COG4771	TonB-dependent receptor
SPH21_RS01920	COG0702	epimerase
SPH21_RS01940	COG2855	membrane
SPH21_RS01945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPH21_RS01950	COG0497	DNA recombination
SPH21_RS01960	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SPH21_RS01965	COG1373	ATPase (AAA superfamily
SPH21_RS02010	COG0542	response to heat
SPH21_RS02015	COG0488	(ABC) transporter
SPH21_RS02035	COG3547	Transposase (IS116 IS110 IS902 family)
SPH21_RS02040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS02045	COG3842	ATPase activity
SPH21_RS02070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS02080	COG1538	Outer membrane efflux protein
SPH21_RS02085	COG0681	Belongs to the peptidase S26 family
SPH21_RS02090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPH21_RS02100	COG1475	DNA binding
SPH21_RS02105	COG1192	Involved in chromosome partitioning
SPH21_RS02115	COG1349	DNA-binding transcription factor activity
SPH21_RS02120	COG4771	TonB-dependent receptor
SPH21_RS02130	COG2814	Major facilitator Superfamily
SPH21_RS02135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPH21_RS02140	COG1070	Carbohydrate kinase
SPH21_RS02145	COG1070	Carbohydrate kinase
SPH21_RS02150	COG0406	alpha-ribazole phosphatase activity
SPH21_RS02160	COG1725	Transcriptional regulator
SPH21_RS02180	COG3408	Glycogen debranching enzyme
SPH21_RS02190	COG3940	Belongs to the glycosyl hydrolase 43 family
SPH21_RS02205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPH21_RS02210	COG0109	protoheme IX farnesyltransferase activity
SPH21_RS02235	COG0673	inositol 2-dehydrogenase activity
SPH21_RS02260	COG0702	epimerase
SPH21_RS02265	COG4771	TonB-dependent receptor
SPH21_RS02280	COG3408	Glycogen debranching enzyme
SPH21_RS02290	COG0673	inositol 2-dehydrogenase activity
SPH21_RS02300	COG3254	rhamnose metabolic process
SPH21_RS02310	COG2755	lipolytic protein G-D-S-L family
SPH21_RS02350	COG4771	TonB-dependent receptor
SPH21_RS02365	COG1629	transport
SPH21_RS02370	COG0702	epimerase
SPH21_RS02375	COG4206	TonB-dependent receptor
SPH21_RS02375	COG1629	transport
SPH21_RS02405	COG3458	cephalosporin-C deacetylase activity
SPH21_RS02425	COG1629	transport
SPH21_RS02430	COG0702	epimerase
SPH21_RS02465	COG1629	transport
SPH21_RS02465	COG4206	TonB-dependent receptor
SPH21_RS02480	COG1629	transport
SPH21_RS02480	COG4206	TonB-dependent receptor
SPH21_RS02505	COG3385	transposase activity
SPH21_RS02525	COG0745	RESPONSE REGULATOR receiver
SPH21_RS02530	COG5002	protein histidine kinase activity
SPH21_RS02540	COG4952	isomerase
SPH21_RS02545	COG3347	Dehydrogenase
SPH21_RS02545	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS02565	COG0612	Peptidase, M16
SPH21_RS02580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPH21_RS02595	COG1607	acyl-coa hydrolase
SPH21_RS02600	COG1446	asparaginase
SPH21_RS02610	COG0697	spore germination
SPH21_RS02625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPH21_RS02650	COG5265	(ABC) transporter
SPH21_RS02655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPH21_RS02660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPH21_RS02680	COG0456	acetyltransferase
SPH21_RS02690	COG0495	leucyl-tRNA aminoacylation
SPH21_RS02695	COG2177	Part of the ABC transporter FtsEX involved in
SPH21_RS02705	COG1968	undecaprenyl-diphosphatase activity
SPH21_RS02710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPH21_RS02715	COG0196	riboflavin kinase activity
SPH21_RS02725	COG2353	YceI-like domain
SPH21_RS02730	COG1765	OsmC-like protein
SPH21_RS02745	COG1959	2 iron, 2 sulfur cluster binding
SPH21_RS02755	COG1595	DNA-templated transcription, initiation
SPH21_RS02765	COG1597	lipid kinase activity
SPH21_RS02765	COG1803	Methylglyoxal synthase
SPH21_RS02790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPH21_RS02790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPH21_RS02800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPH21_RS02810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPH21_RS02815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPH21_RS02850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPH21_RS02850	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPH21_RS02860	COG1904	glucuronate isomerase
SPH21_RS02865	COG1312	Catalyzes the dehydration of D-mannonate
SPH21_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS02880	COG0800	Aldolase
SPH21_RS02885	COG0673	inositol 2-dehydrogenase activity
SPH21_RS02895	COG0702	epimerase
SPH21_RS02900	COG4771	TonB-dependent receptor
SPH21_RS02905	COG2205	protein histidine kinase activity
SPH21_RS02905	COG0745	RESPONSE REGULATOR receiver
SPH21_RS02905	COG3292	Two component regulator propeller
SPH21_RS02910	COG3292	Two component regulator propeller
SPH21_RS02910	COG0745	RESPONSE REGULATOR receiver
SPH21_RS02910	COG2205	protein histidine kinase activity
SPH21_RS02935	COG1132	(ABC) transporter
SPH21_RS02955	COG3507	Belongs to the glycosyl hydrolase 43 family
SPH21_RS02960	COG2017	converts alpha-aldose to the beta-anomer
SPH21_RS02965	COG3250	beta-galactosidase activity
SPH21_RS02990	COG0561	phosphatase activity
SPH21_RS02995	COG4771	TonB-dependent receptor
SPH21_RS03010	COG1609	Transcriptional regulator
SPH21_RS03025	COG0523	cobalamin synthesis protein
SPH21_RS03040	COG0738	Major facilitator superfamily
SPH21_RS03070	COG1629	transport
SPH21_RS03085	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPH21_RS03095	COG2721	sulfolactate sulfo-lyase activity
SPH21_RS03100	COG3254	rhamnose metabolic process
SPH21_RS03110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPH21_RS03110	COG2207	Transcriptional regulator
SPH21_RS03125	COG0673	inositol 2-dehydrogenase activity
SPH21_RS03135	COG1609	Transcriptional regulator
SPH21_RS03150	COG4771	TonB-dependent receptor
SPH21_RS03155	COG4206	TonB-dependent receptor
SPH21_RS03155	COG1629	transport
SPH21_RS03170	COG3547	Transposase (IS116 IS110 IS902 family)
SPH21_RS03175	COG0673	inositol 2-dehydrogenase activity
SPH21_RS03180	COG1629	transport
SPH21_RS03180	COG4206	TonB-dependent receptor
SPH21_RS03195	COG2304	oxidoreductase activity
SPH21_RS03205	COG0346	lactoylglutathione lyase activity
SPH21_RS03210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPH21_RS03225	COG0076	glutamate decarboxylase activity
SPH21_RS03250	COG3275	phosphorelay sensor kinase activity
SPH21_RS03255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPH21_RS03260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPH21_RS03270	COG1556	Lactate utilization protein
SPH21_RS03275	COG1139	Iron-sulfur cluster binding protein
SPH21_RS03280	COG0247	lactate metabolic process
SPH21_RS03285	COG3511	phospholipase C
SPH21_RS03295	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPH21_RS03310	COG0531	amino acid
SPH21_RS03320	COG0792	nuclease activity
SPH21_RS03325	COG0358	DNA primase activity
SPH21_RS03330	COG0668	transmembrane transport
SPH21_RS03345	COG0653	protein targeting
SPH21_RS03370	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPH21_RS03375	COG0717	Belongs to the dCTP deaminase family
SPH21_RS03390	COG3385	transposase activity
SPH21_RS03430	COG3279	Response regulator of the LytR AlgR family
SPH21_RS03450	COG2274	protein secretion by the type I secretion system
SPH21_RS03465	COG0321	lipoyl(octanoyl) transferase activity
SPH21_RS03475	COG1760	l-serine dehydratase
SPH21_RS03515	COG0714	Associated with various cellular activities
SPH21_RS03530	COG1137	ATPase activity
SPH21_RS03535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPH21_RS03535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPH21_RS03550	COG4585	Histidine kinase
SPH21_RS03560	COG0556	nucleotide-excision repair
SPH21_RS03565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPH21_RS03570	COG1011	Hydrolase
SPH21_RS03580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH21_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS03590	COG4677	pectinesterase activity
SPH21_RS03595	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SPH21_RS03605	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH21_RS03610	COG1609	Transcriptional regulator
SPH21_RS03620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SPH21_RS03625	COG1704	LemA family
SPH21_RS03635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SPH21_RS03645	COG2755	lipolytic protein G-D-S-L family
SPH21_RS03645	COG0657	acetylesterase activity
SPH21_RS03665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS03670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPH21_RS03685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPH21_RS03690	COG2204	response regulator
SPH21_RS03710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPH21_RS03715	COG0459	protein refolding
SPH21_RS03740	COG1024	Enoyl-CoA hydratase
SPH21_RS03750	COG2989	Protein conserved in bacteria
SPH21_RS03760	COG1774	PSP1 C-terminal conserved region
SPH21_RS03765	COG0470	DNA polymerase III
SPH21_RS03770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPH21_RS03785	COG3951	Flagellar rod assembly protein muramidase FlgJ
SPH21_RS03785	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPH21_RS03800	COG3023	N-Acetylmuramoyl-L-alanine amidase
SPH21_RS03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPH21_RS03810	COG1278	Cold shock
SPH21_RS03815	COG0513	Belongs to the DEAD box helicase family
SPH21_RS03820	COG0501	Belongs to the peptidase M48B family
SPH21_RS03825	COG1228	amidohydrolase
SPH21_RS03835	COG0346	lactoylglutathione lyase activity
SPH21_RS03845	COG0783	Belongs to the Dps family
SPH21_RS03860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPH21_RS03870	COG1131	(ABC) transporter
SPH21_RS03875	COG1472	Belongs to the glycosyl hydrolase 3 family
SPH21_RS03880	COG1472	Belongs to the glycosyl hydrolase 3 family
SPH21_RS03905	COG0673	inositol 2-dehydrogenase activity
SPH21_RS03930	COG2755	lipolytic protein G-D-S-L family
SPH21_RS03930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SPH21_RS03945	COG1629	transport
SPH21_RS03970	COG1629	transport
SPH21_RS03970	COG4206	TonB-dependent receptor
SPH21_RS03975	COG0702	epimerase
SPH21_RS04005	COG4176	ABC-type proline glycine betaine transport system permease component
SPH21_RS04010	COG4175	Glycine betaine
SPH21_RS04010	COG0517	IMP dehydrogenase activity
SPH21_RS04085	COG1733	regulation of RNA biosynthetic process
SPH21_RS04090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SPH21_RS04125	COG3876	Protein conserved in bacteria
SPH21_RS04135	COG4771	TonB-dependent receptor
SPH21_RS04150	COG0577	efflux transmembrane transporter activity
SPH21_RS04185	COG1484	DNA-dependent DNA replication
SPH21_RS04200	COG3279	Response regulator of the LytR AlgR family
SPH21_RS04210	COG4584	PFAM Integrase catalytic
SPH21_RS04215	COG1484	DNA-dependent DNA replication
SPH21_RS04255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPH21_RS04315	COG3708	Transcriptional regulator
SPH21_RS04315	COG2207	Transcriptional regulator
SPH21_RS04380	COG2814	Major facilitator Superfamily
SPH21_RS04435	COG1741	Belongs to the pirin family
SPH21_RS04450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPH21_RS04455	COG0596	Alpha beta hydrolase
SPH21_RS04465	COG1132	(ABC) transporter
SPH21_RS04475	COG4221	oxidoreductase activity
SPH21_RS04500	COG2207	Transcriptional regulator
SPH21_RS04505	COG0346	lactoylglutathione lyase activity
SPH21_RS04510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPH21_RS04520	COG0300	oxidoreductase activity
SPH21_RS04540	COG4774	siderophore transport
SPH21_RS04545	COG1280	lysine exporter protein (LysE YggA)
SPH21_RS04550	COG0662	Cupin 2, conserved barrel domain protein
SPH21_RS04550	COG2207	Transcriptional regulator
SPH21_RS04560	COG0702	epimerase
SPH21_RS04565	COG1629	transport
SPH21_RS04570	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SPH21_RS04575	COG2211	Major facilitator Superfamily
SPH21_RS04580	COG2942	2-epimerase
SPH21_RS04585	COG4124	Belongs to the glycosyl hydrolase 26 family
SPH21_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS04615	COG1629	transport
SPH21_RS04615	COG4206	TonB-dependent receptor
SPH21_RS04620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPH21_RS04640	COG0667	Aldo Keto reductase
SPH21_RS04665	COG5433	transposase activity
SPH21_RS04675	COG2814	Major facilitator Superfamily
SPH21_RS04680	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SPH21_RS04715	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
SPH21_RS04740	COG2972	Histidine kinase
SPH21_RS04745	COG3279	Response regulator of the LytR AlgR family
SPH21_RS04760	COG1629	transport
SPH21_RS04770	COG1191	sigma factor activity
SPH21_RS04775	COG1733	regulation of RNA biosynthetic process
SPH21_RS04780	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPH21_RS04785	COG0488	(ABC) transporter
SPH21_RS04805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPH21_RS04810	COG3395	kinase activity
SPH21_RS04815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SPH21_RS04820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPH21_RS04825	COG1454	alcohol dehydrogenase
SPH21_RS04830	COG0662	Cupin 2, conserved barrel domain protein
SPH21_RS04830	COG2207	Transcriptional regulator
SPH21_RS04845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPH21_RS04850	COG3938	Belongs to the proline racemase family
SPH21_RS04860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPH21_RS04870	COG0006	proline dipeptidase activity
SPH21_RS04895	COG1629	transport
SPH21_RS04895	COG4206	TonB-dependent receptor
SPH21_RS04910	COG4771	TonB-dependent receptor
SPH21_RS04915	COG0702	epimerase
SPH21_RS04930	COG4771	TonB-dependent receptor
SPH21_RS04955	COG4771	TonB-dependent receptor
SPH21_RS04985	COG1629	transport
SPH21_RS05000	COG0823	Involved in the tonB-independent uptake of proteins
SPH21_RS05000	COG1506	peptidase
SPH21_RS05005	COG0531	amino acid
SPH21_RS05020	COG1082	Xylose isomerase domain protein TIM barrel
SPH21_RS05040	COG3534	alpha-L-arabinofuranosidase
SPH21_RS05055	COG1069	ribulokinase activity
SPH21_RS05065	COG2160	L-arabinose isomerase activity
SPH21_RS05080	COG0137	argininosuccinate synthase activity
SPH21_RS05085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SPH21_RS05100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPH21_RS05105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPH21_RS05120	COG0165	Argininosuccinate lyase
SPH21_RS05125	COG0528	UMP kinase activity
SPH21_RS05130	COG2264	protein methyltransferase activity
SPH21_RS05135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPH21_RS05140	COG0300	oxidoreductase activity
SPH21_RS05150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPH21_RS05155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPH21_RS05185	COG1556	Lactate utilization protein
SPH21_RS05190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPH21_RS05210	COG4232	protein-disulfide reductase activity
SPH21_RS05215	COG0205	6-phosphofructokinase activity
SPH21_RS05230	COG0604	alcohol dehydrogenase
SPH21_RS05235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPH21_RS05240	COG0590	tRNA wobble adenosine to inosine editing
SPH21_RS05245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPH21_RS05250	COG0577	efflux transmembrane transporter activity
SPH21_RS05250	COG1136	(ABC) transporter
SPH21_RS05255	COG1408	metallophosphoesterase
SPH21_RS05260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPH21_RS05265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPH21_RS05270	COG2027	D-alanyl-D-alanine carboxypeptidase
SPH21_RS05280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPH21_RS05300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPH21_RS05305	COG0217	transcriptional regulatory protein
SPH21_RS05320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPH21_RS05325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPH21_RS05340	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPH21_RS05350	COG1595	DNA-templated transcription, initiation
SPH21_RS05370	COG2972	Histidine kinase
SPH21_RS05375	COG3279	Response regulator of the LytR AlgR family
SPH21_RS05385	COG1629	transport
SPH21_RS05395	COG4771	TonB-dependent receptor
SPH21_RS05420	COG4771	TonB-dependent receptor
SPH21_RS05435	COG4771	TonB-dependent receptor
SPH21_RS05440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SPH21_RS05445	COG1793	dna ligase
SPH21_RS05445	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SPH21_RS05450	COG1793	dna ligase
SPH21_RS05455	COG1201	RNA secondary structure unwinding
SPH21_RS05485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SPH21_RS05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS05535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPH21_RS05540	COG1530	ribonuclease E activity
SPH21_RS05550	COG0776	regulation of translation
SPH21_RS05555	COG1194	a g-specific adenine glycosylase
SPH21_RS05565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPH21_RS05570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPH21_RS05580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPH21_RS05585	COG1040	competence protein
SPH21_RS05590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPH21_RS05600	COG1254	Belongs to the acylphosphatase family
SPH21_RS05625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPH21_RS05630	COG1388	LysM domain
SPH21_RS05630	COG0741	lytic transglycosylase activity
SPH21_RS05635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPH21_RS05640	COG0791	NLP P60 protein
SPH21_RS05645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPH21_RS05650	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPH21_RS05670	COG1054	Belongs to the UPF0176 family
SPH21_RS05680	COG2885	chlorophyll binding
SPH21_RS05690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPH21_RS05695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPH21_RS05700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPH21_RS05705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SPH21_RS05710	COG2860	membrane
SPH21_RS05715	COG0242	peptide deformylase activity
SPH21_RS05720	COG0612	Peptidase, M16
SPH21_RS05735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPH21_RS05740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPH21_RS05745	COG2045	Belongs to the ComB family
SPH21_RS05750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPH21_RS05755	COG3852	Histidine kinase
SPH21_RS05760	COG2204	response regulator
SPH21_RS05775	COG1136	(ABC) transporter
SPH21_RS05780	COG0577	efflux transmembrane transporter activity
SPH21_RS05785	COG0577	efflux transmembrane transporter activity
SPH21_RS05795	COG0577	efflux transmembrane transporter activity
SPH21_RS05810	COG1271	oxidase subunit
SPH21_RS05820	COG4773	Receptor
SPH21_RS05835	COG0673	inositol 2-dehydrogenase activity
SPH21_RS05840	COG2080	2 iron, 2 sulfur cluster binding
SPH21_RS05845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPH21_RS05845	COG2010	Cytochrome c
SPH21_RS05850	COG4628	conserved protein (DUF2132)
SPH21_RS05860	COG2814	Major facilitator Superfamily
SPH21_RS05895	COG0577	efflux transmembrane transporter activity
SPH21_RS05895	COG1136	(ABC) transporter
SPH21_RS05900	COG0577	efflux transmembrane transporter activity
SPH21_RS05910	COG0666	response to abiotic stimulus
SPH21_RS05935	COG2361	Protein of unknown function DUF86
SPH21_RS05970	COG0577	efflux transmembrane transporter activity
SPH21_RS05995	COG2824	Alkylphosphonate utilization operon protein PhnA
SPH21_RS06015	COG0534	Mate efflux family protein
SPH21_RS06025	COG0577	efflux transmembrane transporter activity
SPH21_RS06045	COG0577	efflux transmembrane transporter activity
SPH21_RS06045	COG1136	(ABC) transporter
SPH21_RS06055	COG1301	dicarboxylic acid transport
SPH21_RS06085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SPH21_RS06095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SPH21_RS06100	COG0105	UTP biosynthetic process
SPH21_RS06105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPH21_RS06115	COG0084	hydrolase, TatD family'
SPH21_RS06120	COG0252	asparaginase activity
SPH21_RS06125	COG1770	oligopeptidase
SPH21_RS06145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPH21_RS06150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SPH21_RS06160	COG3386	PFAM SMP-30 Gluconolaconase
SPH21_RS06175	COG0242	peptide deformylase activity
SPH21_RS06190	COG2124	cytochrome p450
SPH21_RS06200	COG1629	transport
SPH21_RS06205	COG0702	epimerase
SPH21_RS06220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPH21_RS06225	COG0823	Involved in the tonB-independent uptake of proteins
SPH21_RS06225	COG1506	peptidase
SPH21_RS06280	COG0702	epimerase
SPH21_RS06285	COG4771	TonB-dependent receptor
SPH21_RS06360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPH21_RS06375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SPH21_RS06380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SPH21_RS06385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SPH21_RS06390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SPH21_RS06400	COG0445	tRNA wobble uridine modification
SPH21_RS06405	COG0488	(ABC) transporter
SPH21_RS06410	COG2967	ApaG domain
SPH21_RS06415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPH21_RS06425	COG4589	Belongs to the CDS family
SPH21_RS06430	COG0124	histidyl-tRNA synthetase
SPH21_RS06440	COG1522	sequence-specific DNA binding
SPH21_RS06445	COG0022	dehydrogenase e1 component
SPH21_RS06445	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPH21_RS06455	COG1074	ATP-dependent DNA helicase activity
SPH21_RS06470	COG1649	PFAM Uncharacterised BCR, COG1649
SPH21_RS06480	COG5000	phosphorelay sensor kinase activity
SPH21_RS06485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPH21_RS06490	COG0302	gtp cyclohydrolase
SPH21_RS06505	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SPH21_RS06510	COG3387	PFAM Glycoside hydrolase 15-related
SPH21_RS06515	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SPH21_RS06520	COG0228	four-way junction DNA binding
SPH21_RS06525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPH21_RS06530	COG0336	Belongs to the RNA methyltransferase TrmD family
SPH21_RS06535	COG0335	large ribosomal subunit rRNA binding
SPH21_RS06540	COG1418	mRNA catabolic process
SPH21_RS06550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPH21_RS06550	COG0116	Belongs to the methyltransferase superfamily
SPH21_RS06570	COG3781	membrane
SPH21_RS06575	COG1012	belongs to the aldehyde dehydrogenase family
SPH21_RS06585	COG1809	phosphosulfolactate synthase activity
SPH21_RS06590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPH21_RS06600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPH21_RS06605	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPH21_RS06610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPH21_RS06640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPH21_RS06645	COG1695	Transcriptional regulator
SPH21_RS06655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPH21_RS06665	COG0469	pyruvate kinase activity
SPH21_RS06675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPH21_RS06680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPH21_RS06685	COG0571	ribonuclease III activity
SPH21_RS06690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPH21_RS06705	COG0778	Nitroreductase
SPH21_RS06720	COG0489	protein tyrosine kinase activity
SPH21_RS06725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPH21_RS06735	COG0688	phosphatidylethanolamine metabolic process
SPH21_RS06740	COG5002	protein histidine kinase activity
SPH21_RS06750	COG0306	phosphate transporter
SPH21_RS06775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPH21_RS06790	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPH21_RS06795	COG1490	D-aminoacyl-tRNA deacylase activity
SPH21_RS06800	COG1694	Mazg nucleotide pyrophosphohydrolase
SPH21_RS06805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPH21_RS06810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPH21_RS06815	COG2022	thiamine diphosphate biosynthetic process
SPH21_RS06820	COG0352	thiamine-phosphate diphosphorylase activity
SPH21_RS06830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPH21_RS06845	COG0708	Exodeoxyribonuclease III
SPH21_RS06875	COG0793	Belongs to the peptidase S41A family
SPH21_RS06880	COG3279	Response regulator of the LytR AlgR family
SPH21_RS06910	COG1053	succinate dehydrogenase
SPH21_RS06920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPH21_RS06940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPH21_RS06975	COG1054	Belongs to the UPF0176 family
SPH21_RS06985	COG4771	TonB-dependent receptor
SPH21_RS06990	COG0702	epimerase
SPH21_RS07020	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPH21_RS07025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPH21_RS07025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPH21_RS07030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPH21_RS07035	COG0083	homoserine kinase activity
SPH21_RS07040	COG0460	homoserine dehydrogenase
SPH21_RS07040	COG0527	aspartate kinase activity
SPH21_RS07045	COG0233	cytoplasmic translational termination
SPH21_RS07065	COG1162	GTPase activity
SPH21_RS07070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPH21_RS07100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPH21_RS07105	COG0606	chelatase, subunit chli
SPH21_RS07110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPH21_RS07115	COG0052	Belongs to the universal ribosomal protein uS2 family
SPH21_RS07120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPH21_RS07125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPH21_RS07130	COG0534	Mate efflux family protein
SPH21_RS07145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPH21_RS07150	COG2814	Major facilitator Superfamily
SPH21_RS07155	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SPH21_RS07160	COG3250	beta-galactosidase activity
SPH21_RS07165	COG1505	serine-type exopeptidase activity
SPH21_RS07175	COG1722	exodeoxyribonuclease VII activity
SPH21_RS07185	COG4206	TonB-dependent receptor
SPH21_RS07185	COG1629	transport
SPH21_RS07195	COG0156	8-amino-7-oxononanoate synthase activity
SPH21_RS07200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPH21_RS07210	COG1309	transcriptional regulator
SPH21_RS07215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPH21_RS07230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPH21_RS07245	COG3547	Transposase (IS116 IS110 IS902 family)
SPH21_RS07250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPH21_RS07260	COG0215	cysteine-tRNA ligase activity
SPH21_RS07280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPH21_RS07295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS07300	COG0450	alkyl hydroperoxide reductase
SPH21_RS07305	COG2827	Endonuclease containing a URI domain
SPH21_RS07340	COG1538	Outer membrane efflux protein
SPH21_RS07345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SPH21_RS07350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPH21_RS07375	COG2818	Glycosylase
SPH21_RS07385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPH21_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS07410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SPH21_RS07430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPH21_RS07435	COG0512	Glutamine amidotransferase of anthranilate synthase
SPH21_RS07440	COG0134	indole-3-glycerol-phosphate synthase activity
SPH21_RS07445	COG0363	glucosamine-6-phosphate deaminase activity
SPH21_RS07465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPH21_RS07470	COG0194	GDP metabolic process
SPH21_RS07475	COG1561	YicC-like family, N-terminal region
SPH21_RS07485	COG0612	Peptidase, M16
SPH21_RS07495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPH21_RS07495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPH21_RS07505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPH21_RS07510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPH21_RS07515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPH21_RS07600	COG0686	Belongs to the AlaDH PNT family
SPH21_RS07610	COG2197	response regulator
SPH21_RS07615	COG1078	dGTPase activity
SPH21_RS07620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SPH21_RS07625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPH21_RS07625	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SPH21_RS07630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SPH21_RS07635	COG1131	(ABC) transporter
SPH21_RS07640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPH21_RS07645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPH21_RS07665	COG0437	4 iron, 4 sulfur cluster binding
SPH21_RS07690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPH21_RS07695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPH21_RS07705	COG0109	protoheme IX farnesyltransferase activity
SPH21_RS07710	COG1845	cytochrome c oxidase, subunit III
SPH21_RS07715	COG1845	cytochrome c oxidase, subunit III
SPH21_RS07730	COG2322	membrane
SPH21_RS07765	COG5002	protein histidine kinase activity
SPH21_RS07770	COG0745	RESPONSE REGULATOR receiver
SPH21_RS07775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPH21_RS07785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SPH21_RS07795	COG1215	transferase activity, transferring glycosyl groups
SPH21_RS07805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPH21_RS07810	COG1597	lipid kinase activity
SPH21_RS07835	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SPH21_RS07855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS07860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS07865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS07870	COG0649	NAD binding
SPH21_RS07875	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SPH21_RS07885	COG1034	ATP synthesis coupled electron transport
SPH21_RS07890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPH21_RS07895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS07900	COG0839	Belongs to the complex I subunit 6 family
SPH21_RS07905	COG0713	ATP synthesis coupled electron transport
SPH21_RS07910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPH21_RS07915	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS07920	COG1007	ATP synthesis coupled electron transport
SPH21_RS07925	COG0586	Pfam SNARE associated Golgi protein
SPH21_RS07935	COG1253	flavin adenine dinucleotide binding
SPH21_RS07940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPH21_RS07945	COG0287	Prephenate dehydrogenase
SPH21_RS07955	COG1132	(ABC) transporter
SPH21_RS07960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPH21_RS07960	COG5180	pathogenesis
SPH21_RS07965	COG0195	Participates in both transcription termination and antitermination
SPH21_RS07970	COG0779	Required for maturation of 30S ribosomal subunits
SPH21_RS07980	COG2706	6-phosphogluconolactonase activity
SPH21_RS07985	COG0438	transferase activity, transferring glycosyl groups
SPH21_RS07990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPH21_RS08000	COG3591	Belongs to the peptidase S1B family
SPH21_RS08005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPH21_RS08010	COG0673	inositol 2-dehydrogenase activity
SPH21_RS08020	COG0037	tRNA processing
SPH21_RS08070	COG1217	gtp-binding protein TYPA
SPH21_RS08075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPH21_RS08080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPH21_RS08090	COG0297	glycogen (starch) synthase activity
SPH21_RS08095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SPH21_RS08100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SPH21_RS08105	COG0745	RESPONSE REGULATOR receiver
SPH21_RS08115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPH21_RS08130	COG1960	acyl-CoA dehydrogenase activity
SPH21_RS08145	COG0788	formyltetrahydrofolate deformylase activity
SPH21_RS08150	COG4771	TonB-dependent receptor
SPH21_RS08160	COG0667	Aldo Keto reductase
SPH21_RS08170	COG3547	Transposase (IS116 IS110 IS902 family)
SPH21_RS08185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPH21_RS08195	COG1053	succinate dehydrogenase
SPH21_RS08195	COG3976	FMN-binding domain protein
SPH21_RS08215	COG0702	epimerase
SPH21_RS08220	COG1629	transport
SPH21_RS08220	COG4206	TonB-dependent receptor
SPH21_RS08245	COG0116	Belongs to the methyltransferase superfamily
SPH21_RS08245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPH21_RS08250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPH21_RS08255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPH21_RS08260	COG4221	oxidoreductase activity
SPH21_RS08280	COG1309	transcriptional regulator
SPH21_RS08300	COG3385	transposase activity
SPH21_RS08315	COG0415	Belongs to the DNA photolyase family
SPH21_RS08320	COG1090	epimerase
SPH21_RS08330	COG0415	Belongs to the DNA photolyase family
SPH21_RS08335	COG0567	Dehydrogenase, E1 component
SPH21_RS08360	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
SPH21_RS08375	COG1368	sulfuric ester hydrolase activity
SPH21_RS08380	COG1368	sulfuric ester hydrolase activity
SPH21_RS08385	COG2814	Major facilitator Superfamily
SPH21_RS08395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS08410	COG1309	transcriptional regulator
SPH21_RS08415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPH21_RS08420	COG1595	DNA-templated transcription, initiation
SPH21_RS08445	COG1252	NADH dehydrogenase
SPH21_RS08450	COG0423	glycine-tRNA ligase activity
SPH21_RS08455	COG0584	glycerophosphoryl diester phosphodiesterase
SPH21_RS08460	COG1131	(ABC) transporter
SPH21_RS08475	COG0427	acetyl-CoA hydrolase
SPH21_RS08485	COG0592	DNA-directed DNA polymerase activity
SPH21_RS08490	COG0586	Pfam SNARE associated Golgi protein
SPH21_RS08495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPH21_RS08500	COG0088	Forms part of the polypeptide exit tunnel
SPH21_RS08505	COG0089	rRNA binding
SPH21_RS08510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPH21_RS08515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPH21_RS08520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPH21_RS08525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPH21_RS08530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPH21_RS08535	COG0255	Belongs to the universal ribosomal protein uL29 family
SPH21_RS08540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPH21_RS08545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPH21_RS08550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SPH21_RS08555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPH21_RS08560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPH21_RS08565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPH21_RS08570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPH21_RS08580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPH21_RS08585	COG1841	ribosomal large subunit assembly
SPH21_RS08590	COG0200	Binds to the 23S rRNA
SPH21_RS08605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPH21_RS08610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPH21_RS08615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPH21_RS08620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPH21_RS08625	COG0202	RNA polymerase activity
SPH21_RS08630	COG0203	ribosomal protein L17
SPH21_RS08640	COG0443	Heat shock 70 kDa protein
SPH21_RS08645	COG1011	Hydrolase
SPH21_RS08655	COG0277	FAD linked oxidase domain protein
SPH21_RS08660	COG0823	Involved in the tonB-independent uptake of proteins
SPH21_RS08660	COG1506	peptidase
SPH21_RS08670	COG0433	COG0433 Predicted ATPase
SPH21_RS08680	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPH21_RS08685	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SPH21_RS08690	COG3250	beta-galactosidase activity
SPH21_RS08735	COG1247	-acetyltransferase
SPH21_RS08750	COG3511	phospholipase C
SPH21_RS08765	COG4771	TonB-dependent receptor
SPH21_RS08780	COG0702	epimerase
SPH21_RS08785	COG4771	TonB-dependent receptor
SPH21_RS08800	COG2244	polysaccharide biosynthetic process
SPH21_RS08810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPH21_RS08850	COG1216	Glycosyl transferase, family 2
SPH21_RS08855	COG0110	maltose O-acetyltransferase activity
SPH21_RS08895	COG1215	transferase activity, transferring glycosyl groups
SPH21_RS08905	COG1215	transferase activity, transferring glycosyl groups
SPH21_RS08960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SPH21_RS08970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPH21_RS08980	COG2089	acid synthase
SPH21_RS08985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPH21_RS08990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPH21_RS09060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SPH21_RS09100	COG1309	transcriptional regulator
SPH21_RS09105	COG1764	response to oxidative stress
SPH21_RS09145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS09150	COG4206	TonB-dependent receptor
SPH21_RS09150	COG1629	transport
SPH21_RS09155	COG0702	epimerase
SPH21_RS09185	COG3279	Response regulator of the LytR AlgR family
SPH21_RS09250	COG1629	transport
SPH21_RS09290	COG1629	transport
SPH21_RS09300	COG3292	Two component regulator propeller
SPH21_RS09300	COG0745	RESPONSE REGULATOR receiver
SPH21_RS09300	COG2205	protein histidine kinase activity
SPH21_RS09305	COG4771	TonB-dependent receptor
SPH21_RS09325	COG0702	epimerase
SPH21_RS09330	COG1629	transport
SPH21_RS09365	COG2274	protein secretion by the type I secretion system
SPH21_RS09385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPH21_RS09390	COG4771	TonB-dependent receptor
SPH21_RS09410	COG1629	transport
SPH21_RS09430	COG3250	beta-galactosidase activity
SPH21_RS09435	COG1609	Transcriptional regulator
SPH21_RS09435	COG2207	Transcriptional regulator
SPH21_RS09445	COG1966	Carbon starvation protein
SPH21_RS09455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPH21_RS09470	COG0402	S-adenosylhomocysteine deaminase activity
SPH21_RS09485	COG1629	transport
SPH21_RS09490	COG0702	epimerase
SPH21_RS09505	COG0666	response to abiotic stimulus
SPH21_RS09510	COG0402	S-adenosylhomocysteine deaminase activity
SPH21_RS09525	COG4771	TonB-dependent receptor
SPH21_RS09530	COG0702	epimerase
SPH21_RS09545	COG1629	transport
SPH21_RS09545	COG4206	TonB-dependent receptor
SPH21_RS09560	COG3279	Response regulator of the LytR AlgR family
SPH21_RS09585	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SPH21_RS09640	COG0438	transferase activity, transferring glycosyl groups
SPH21_RS09650	COG0110	maltose O-acetyltransferase activity
SPH21_RS09655	COG0463	Glycosyl transferase, family 2
SPH21_RS09660	COG0297	glycogen (starch) synthase activity
SPH21_RS09675	COG3206	protein involved in exopolysaccharide biosynthesis
SPH21_RS09675	COG0489	protein tyrosine kinase activity
SPH21_RS09680	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPH21_RS09695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPH21_RS09710	COG4771	TonB-dependent receptor
SPH21_RS09715	COG0702	epimerase
SPH21_RS09735	COG1629	transport
SPH21_RS09750	COG3250	beta-galactosidase activity
SPH21_RS09755	COG0702	epimerase
SPH21_RS09760	COG4771	TonB-dependent receptor
SPH21_RS09765	COG2205	protein histidine kinase activity
SPH21_RS09765	COG3292	Two component regulator propeller
SPH21_RS09765	COG0745	RESPONSE REGULATOR receiver
SPH21_RS09805	COG0564	pseudouridine synthase activity
SPH21_RS09825	COG4771	TonB-dependent receptor
SPH21_RS09830	COG0702	epimerase
SPH21_RS09870	COG1643	Atp-dependent helicase
SPH21_RS09900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPH21_RS09905	COG2197	response regulator
SPH21_RS09935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPH21_RS09965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPH21_RS09985	COG1216	Glycosyl transferase, family 2
SPH21_RS10020	COG0438	transferase activity, transferring glycosyl groups
SPH21_RS10025	COG1045	serine acetyltransferase
SPH21_RS10070	COG2204	response regulator
SPH21_RS10090	COG3852	Histidine kinase
SPH21_RS10105	COG3385	transposase activity
SPH21_RS10130	COG4771	TonB-dependent receptor
SPH21_RS10145	COG3537	Alpha-1,2-mannosidase
SPH21_RS10155	COG3537	Alpha-1,2-mannosidase
SPH21_RS10165	COG2205	protein histidine kinase activity
SPH21_RS10175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPH21_RS10185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPH21_RS10220	COG1216	Glycosyl transferase, family 2
SPH21_RS10235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPH21_RS10240	COG0784	Response regulator, receiver
SPH21_RS10240	COG2205	protein histidine kinase activity
SPH21_RS10245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPH21_RS10250	COG0598	Magnesium transport protein CorA
SPH21_RS10270	COG0494	nUDIX hydrolase
SPH21_RS10280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPH21_RS10280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPH21_RS10295	COG0632	four-way junction helicase activity
SPH21_RS10305	COG4932	domain protein
SPH21_RS10305	COG1388	LysM domain
SPH21_RS10305	COG2373	Large extracellular alpha-helical protein
SPH21_RS10315	COG2885	chlorophyll binding
SPH21_RS10320	COG2197	response regulator
SPH21_RS10330	COG2201	protein-glutamate methylesterase activity
SPH21_RS10335	COG3275	phosphorelay sensor kinase activity
SPH21_RS10385	COG0494	nUDIX hydrolase
SPH21_RS10395	COG0745	RESPONSE REGULATOR receiver
SPH21_RS10410	COG4771	TonB-dependent receptor
SPH21_RS10425	COG1429	ligase activity, forming nitrogen-metal bonds
SPH21_RS10445	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SPH21_RS10475	COG1278	Cold shock
SPH21_RS10540	COG0628	permease
SPH21_RS10545	COG3237	CsbD-like
SPH21_RS10555	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS10590	COG3258	Cytochrome c
SPH21_RS10595	COG1335	isochorismatase
SPH21_RS10620	COG4251	negative regulation of phosphorylation
SPH21_RS10650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPH21_RS10695	COG2323	membrane
SPH21_RS10700	COG0745	RESPONSE REGULATOR receiver
SPH21_RS10725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPH21_RS10730	COG0366	Alpha amylase catalytic
SPH21_RS10735	COG0366	Alpha amylase catalytic
SPH21_RS10740	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPH21_RS10750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPH21_RS10770	COG3546	catalase activity
SPH21_RS10775	COG5002	protein histidine kinase activity
SPH21_RS10780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPH21_RS10785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPH21_RS10810	COG0509	glycine decarboxylation via glycine cleavage system
SPH21_RS10840	COG3132	Protein of unknown function, DUF480
SPH21_RS10845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPH21_RS10850	COG0028	Belongs to the TPP enzyme family
SPH21_RS10855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPH21_RS10870	COG0713	ATP synthesis coupled electron transport
SPH21_RS10875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPH21_RS10885	COG1007	ATP synthesis coupled electron transport
SPH21_RS10890	COG0004	ammonium transporteR
SPH21_RS10895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPH21_RS10910	COG2226	methyltransferase
SPH21_RS10915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SPH21_RS10925	COG1528	Iron-storage protein
SPH21_RS10940	COG0285	dihydrofolate synthase activity
SPH21_RS10955	COG0811	peptide transport
SPH21_RS10975	COG0540	Belongs to the ATCase OTCase family
SPH21_RS10995	COG2321	neutral zinc metallopeptidase
SPH21_RS11010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SPH21_RS11015	COG0825	malonyl-CoA metabolic process
SPH21_RS11025	COG0519	Catalyzes the synthesis of GMP from XMP
SPH21_RS11025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPH21_RS11035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPH21_RS11035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPH21_RS11045	COG2095	MarC family integral membrane protein
SPH21_RS11050	COG0531	amino acid
SPH21_RS11055	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SPH21_RS11060	COG0531	amino acid
SPH21_RS11070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPH21_RS11080	COG1960	acyl-CoA dehydrogenase activity
SPH21_RS11085	COG0579	oxidoreductase
SPH21_RS11090	COG1940	carbohydrate kinase activity
SPH21_RS11130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPH21_RS11160	COG1629	transport
SPH21_RS11210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPH21_RS11220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPH21_RS11235	COG0066	3-isopropylmalate dehydratase activity
SPH21_RS11240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPH21_RS11245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPH21_RS11250	COG1119	ATPase activity
SPH21_RS11255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPH21_RS11275	COG0028	Belongs to the TPP enzyme family
SPH21_RS11285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPH21_RS11310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPH21_RS11325	COG4864	UPF0365 protein
SPH21_RS11330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPH21_RS11355	COG3250	beta-galactosidase activity
SPH21_RS11365	COG4206	TonB-dependent receptor
SPH21_RS11365	COG1629	transport
SPH21_RS11370	COG0702	epimerase
SPH21_RS11405	COG3250	beta-galactosidase activity
SPH21_RS11410	COG3250	beta-galactosidase activity
SPH21_RS11465	COG3408	Glycogen debranching enzyme
SPH21_RS11475	COG3250	beta-galactosidase activity
SPH21_RS11490	COG1629	transport
SPH21_RS11495	COG0702	epimerase
SPH21_RS11525	COG3547	Transposase (IS116 IS110 IS902 family)
SPH21_RS11545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPH21_RS11550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPH21_RS11570	COG0738	Major facilitator superfamily
SPH21_RS11575	COG3940	Belongs to the glycosyl hydrolase 43 family
SPH21_RS11595	COG0359	binds to the 23S rRNA
SPH21_RS11600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPH21_RS11605	COG0360	Binds together with S18 to 16S ribosomal RNA
SPH21_RS11610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPH21_RS11625	COG4771	TonB-dependent receptor
SPH21_RS11630	COG0702	epimerase
SPH21_RS11640	COG2885	chlorophyll binding
SPH21_RS11645	COG2181	nitrate reductase activity
SPH21_RS11645	COG0247	lactate metabolic process
SPH21_RS11650	COG0247	lactate metabolic process
SPH21_RS11650	COG2181	nitrate reductase activity
SPH21_RS11655	COG1506	peptidase
SPH21_RS11655	COG4946	Tricorn protease homolog
SPH21_RS11655	COG0823	Involved in the tonB-independent uptake of proteins
SPH21_RS11665	COG0494	nUDIX hydrolase
SPH21_RS11670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPH21_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS11680	COG1733	regulation of RNA biosynthetic process
SPH21_RS11685	COG1914	H( )-stimulated, divalent metal cation uptake system
SPH21_RS11695	COG3015	lipoprotein NlpE involved in copper resistance
SPH21_RS11705	COG0561	phosphatase activity
SPH21_RS11710	COG4771	TonB-dependent receptor
SPH21_RS11715	COG1435	thymidine kinase activity
SPH21_RS11725	COG0772	Belongs to the SEDS family
SPH21_RS11745	COG1077	Cell shape determining protein MreB Mrl
SPH21_RS11760	COG0138	bifunctional purine biosynthesis protein purh
SPH21_RS11780	COG3279	Response regulator of the LytR AlgR family
SPH21_RS11785	COG3275	phosphorelay sensor kinase activity
SPH21_RS11805	COG0477	Major facilitator Superfamily
SPH21_RS11820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SPH21_RS11835	COG4974	Belongs to the 'phage' integrase family
SPH21_RS11885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPH21_RS11890	COG0081	regulation of translation
SPH21_RS11895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPH21_RS11900	COG0222	ribosome binding
SPH21_RS11905	COG0085	RNA polymerase activity
SPH21_RS11910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPH21_RS11925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SPH21_RS11930	COG1595	DNA-templated transcription, initiation
SPH21_RS11955	COG0101	tRNA pseudouridine synthase activity
SPH21_RS11960	COG1132	(ABC) transporter
SPH21_RS11965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SPH21_RS11970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPH21_RS11975	COG3537	Alpha-1,2-mannosidase
SPH21_RS11990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPH21_RS12000	COG0617	tRNA 3'-terminal CCA addition
SPH21_RS12000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPH21_RS12000	COG0517	IMP dehydrogenase activity
SPH21_RS12005	COG0009	L-threonylcarbamoyladenylate synthase
SPH21_RS12010	COG0438	transferase activity, transferring glycosyl groups
SPH21_RS12015	COG2171	N-acyltransferase activity
SPH21_RS12030	COG0671	phosphoesterase, PA-phosphatase related
SPH21_RS12035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPH21_RS12065	COG1216	Glycosyl transferase, family 2
SPH21_RS12065	COG0463	Glycosyl transferase, family 2
SPH21_RS12095	COG1360	Flagellar Motor Protein
SPH21_RS12105	COG4771	TonB-dependent receptor
SPH21_RS12110	COG0666	response to abiotic stimulus
SPH21_RS12130	COG1090	epimerase
SPH21_RS12170	COG0187	DNA topoisomerase II activity
SPH21_RS12180	COG0525	valine-tRNA ligase activity
SPH21_RS12205	COG0488	(ABC) transporter
SPH21_RS12215	COG3153	acetyltransferase
SPH21_RS12215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPH21_RS12220	COG2255	four-way junction helicase activity
SPH21_RS12225	COG0463	Glycosyl transferase, family 2
SPH21_RS12230	COG3104	oligopeptide transport
SPH21_RS12250	COG0183	Belongs to the thiolase family
SPH21_RS12305	COG4452	Inner membrane protein CreD
SPH21_RS12315	COG4771	TonB-dependent receptor
SPH21_RS12320	COG1733	regulation of RNA biosynthetic process
SPH21_RS12325	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPH21_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS12350	COG1595	DNA-templated transcription, initiation
SPH21_RS12360	COG1629	transport
SPH21_RS12370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SPH21_RS12385	COG1629	transport
SPH21_RS12400	COG0697	spore germination
SPH21_RS12455	COG1959	2 iron, 2 sulfur cluster binding
SPH21_RS12500	COG0343	queuine tRNA-ribosyltransferase activity
SPH21_RS12510	COG0357	Ribosomal RNA small subunit methyltransferase G
SPH21_RS12515	COG0758	DNA mediated transformation
SPH21_RS12520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPH21_RS12525	COG1132	(ABC) transporter
SPH21_RS12535	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
SPH21_RS12540	COG1702	phosphate starvation-inducible protein PhoH
SPH21_RS12545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPH21_RS12555	COG1234	tRNA 3'-trailer cleavage
SPH21_RS12570	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPH21_RS12580	COG1058	Belongs to the CinA family
SPH21_RS12580	COG1546	Belongs to the CinA family
SPH21_RS12585	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPH21_RS12595	COG2183	response to ionizing radiation
SPH21_RS12600	COG1823	symporter activity
SPH21_RS12615	COG0666	response to abiotic stimulus
SPH21_RS12620	COG4771	TonB-dependent receptor
SPH21_RS12690	COG5002	protein histidine kinase activity
SPH21_RS12715	COG0861	Integral membrane protein TerC family
SPH21_RS12720	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SPH21_RS12725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPH21_RS12730	COG1174	glycine betaine transport
SPH21_RS12735	COG0517	IMP dehydrogenase activity
SPH21_RS12735	COG1125	glycine betaine transport
SPH21_RS12740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPH21_RS12745	COG1902	pentaerythritol trinitrate reductase activity
SPH21_RS12770	COG0025	NhaP-type Na H and K H
SPH21_RS12775	COG1280	lysine exporter protein (LysE YggA)
SPH21_RS12800	COG3832	glyoxalase III activity
SPH21_RS12805	COG1917	Cupin 2, conserved barrel domain protein
SPH21_RS12805	COG2207	Transcriptional regulator
SPH21_RS12810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPH21_RS12825	COG0523	cobalamin synthesis protein
SPH21_RS12840	COG1136	(ABC) transporter
SPH21_RS12860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SPH21_RS12885	COG1538	Outer membrane efflux protein
SPH21_RS12900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPH21_RS12940	COG0577	efflux transmembrane transporter activity
SPH21_RS12960	COG0431	NADPH-dependent FMN reductase
SPH21_RS12965	COG1349	DNA-binding transcription factor activity
SPH21_RS12975	COG3959	Transketolase, thiamine diphosphate binding domain
SPH21_RS12980	COG3958	Transketolase
SPH21_RS12995	COG1129	ABC transporter
SPH21_RS13000	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPH21_RS13005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPH21_RS13015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPH21_RS13020	COG1733	regulation of RNA biosynthetic process
SPH21_RS13025	COG2814	Major facilitator Superfamily
SPH21_RS13035	COG1309	transcriptional regulator
SPH21_RS13045	COG4771	TonB-dependent receptor
SPH21_RS13080	COG0385	Bile acid
SPH21_RS13090	COG4948	Mandelate Racemase Muconate Lactonizing
SPH21_RS13105	COG1629	transport
SPH21_RS13105	COG4206	TonB-dependent receptor
SPH21_RS13115	COG0745	RESPONSE REGULATOR receiver
SPH21_RS13115	COG3292	Two component regulator propeller
SPH21_RS13115	COG2205	protein histidine kinase activity
SPH21_RS13120	COG1874	Beta-galactosidase
SPH21_RS13125	COG3507	Belongs to the glycosyl hydrolase 43 family
SPH21_RS13130	COG1874	Beta-galactosidase
SPH21_RS13135	COG1629	transport
SPH21_RS13140	COG0702	epimerase
SPH21_RS13145	COG3507	Belongs to the glycosyl hydrolase 43 family
SPH21_RS13155	COG3507	Belongs to the glycosyl hydrolase 43 family
SPH21_RS13160	COG3507	Belongs to the glycosyl hydrolase 43 family
SPH21_RS13160	COG2382	esterase
SPH21_RS13160	COG3693	PFAM glycoside hydrolase, family 10
SPH21_RS13165	COG2205	protein histidine kinase activity
SPH21_RS13165	COG3292	Two component regulator propeller
SPH21_RS13165	COG0745	RESPONSE REGULATOR receiver
SPH21_RS13185	COG0561	phosphatase activity
SPH21_RS13190	COG4771	TonB-dependent receptor
SPH21_RS13215	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPH21_RS13240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS13255	COG2814	Major facilitator Superfamily
SPH21_RS13280	COG2169	Transcriptional regulator
SPH21_RS13280	COG1917	Cupin 2, conserved barrel domain protein
SPH21_RS13295	COG0545	Peptidyl-prolyl cis-trans isomerase
SPH21_RS13315	COG2211	Major facilitator Superfamily
SPH21_RS13320	COG0746	molybdenum cofactor guanylyltransferase activity
SPH21_RS13360	COG0243	molybdopterin cofactor binding
SPH21_RS13365	COG0437	4 iron, 4 sulfur cluster binding
SPH21_RS13400	COG0659	secondary active sulfate transmembrane transporter activity
SPH21_RS13405	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS13445	COG1984	allophanate hydrolase subunit 2
SPH21_RS13450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPH21_RS13455	COG2326	polyphosphate kinase activity
SPH21_RS13465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPH21_RS13470	COG0494	nUDIX hydrolase
SPH21_RS13495	COG1333	cytochrome c biogenesis protein
SPH21_RS13495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPH21_RS13510	COG2094	Belongs to the DNA glycosylase MPG family
SPH21_RS13600	COG2378	regulation of single-species biofilm formation
SPH21_RS13610	COG2890	protein-(glutamine-N5) methyltransferase activity
SPH21_RS13620	COG3634	alkyl hydroperoxide reductase activity
SPH21_RS13630	COG0673	inositol 2-dehydrogenase activity
SPH21_RS13635	COG2186	Transcriptional regulator
SPH21_RS13645	COG0456	acetyltransferase
SPH21_RS13645	COG1846	Transcriptional regulator
SPH21_RS13660	COG4771	TonB-dependent receptor
SPH21_RS13665	COG0702	epimerase
SPH21_RS13680	COG4771	TonB-dependent receptor
SPH21_RS13685	COG0702	epimerase
SPH21_RS13720	COG0586	Pfam SNARE associated Golgi protein
SPH21_RS13730	COG1733	regulation of RNA biosynthetic process
SPH21_RS13735	COG0667	Aldo Keto reductase
SPH21_RS13760	COG1629	transport
SPH21_RS13760	COG4206	TonB-dependent receptor
SPH21_RS13770	COG4948	Mandelate Racemase Muconate Lactonizing
SPH21_RS13780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SPH21_RS13795	COG4771	TonB-dependent receptor
SPH21_RS13825	COG4771	TonB-dependent receptor
SPH21_RS13830	COG0702	epimerase
SPH21_RS13835	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH21_RS13845	COG2169	Transcriptional regulator
SPH21_RS13845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPH21_RS13875	COG1522	sequence-specific DNA binding
SPH21_RS13900	COG0640	Transcriptional regulator
SPH21_RS13910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPH21_RS13950	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPH21_RS13955	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPH21_RS13975	COG0326	Molecular chaperone. Has ATPase activity
SPH21_RS13995	COG0740	serine-type endopeptidase activity
SPH21_RS14010	COG2226	methyltransferase
SPH21_RS14015	COG0583	DNA-binding transcription factor activity
SPH21_RS14030	COG1247	-acetyltransferase
SPH21_RS14050	COG2154	pterin-4-alpha-carbinolamine dehydratase
SPH21_RS14055	COG1538	Outer membrane efflux protein
SPH21_RS14065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS14075	COG0791	NLP P60 protein
SPH21_RS14095	COG4771	TonB-dependent receptor
SPH21_RS14100	COG0702	epimerase
SPH21_RS14110	COG1511	domain protein
SPH21_RS14110	COG3264	Mechanosensitive ion channel
SPH21_RS14115	COG1609	Transcriptional regulator
SPH21_RS14130	COG1629	transport
SPH21_RS14140	COG0673	inositol 2-dehydrogenase activity
SPH21_RS14155	COG3385	transposase activity
SPH21_RS14175	COG0673	inositol 2-dehydrogenase activity
SPH21_RS14205	COG4771	TonB-dependent receptor
SPH21_RS14210	COG0071	Belongs to the small heat shock protein (HSP20) family
SPH21_RS14225	COG4771	TonB-dependent receptor
SPH21_RS14230	COG0702	epimerase
SPH21_RS14240	COG3250	beta-galactosidase activity
SPH21_RS14265	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH21_RS14270	COG2205	protein histidine kinase activity
SPH21_RS14270	COG3292	Two component regulator propeller
SPH21_RS14270	COG0745	RESPONSE REGULATOR receiver
SPH21_RS14275	COG0667	Aldo Keto reductase
SPH21_RS14310	COG1082	Xylose isomerase domain protein TIM barrel
SPH21_RS14315	COG1609	Transcriptional regulator
SPH21_RS14320	COG2755	lipolytic protein G-D-S-L family
SPH21_RS14350	COG1629	transport
SPH21_RS14360	COG1629	transport
SPH21_RS14375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH21_RS14380	COG0246	Mannitol dehydrogenase
SPH21_RS14385	COG2721	sulfolactate sulfo-lyase activity
SPH21_RS14390	COG1904	glucuronate isomerase
SPH21_RS14400	COG0738	Major facilitator superfamily
SPH21_RS14405	COG3547	Transposase (IS116 IS110 IS902 family)
SPH21_RS14415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPH21_RS14440	COG0702	epimerase
SPH21_RS14445	COG1629	transport
SPH21_RS14460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPH21_RS14470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPH21_RS14475	COG1349	DNA-binding transcription factor activity
SPH21_RS14480	COG3118	belongs to the thioredoxin family
SPH21_RS14490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPH21_RS14495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPH21_RS14505	COG3781	membrane
SPH21_RS14520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPH21_RS14550	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPH21_RS14560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SPH21_RS14565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPH21_RS14575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPH21_RS14610	COG0658	competence protein
SPH21_RS14610	COG2333	competence protein COMEC
SPH21_RS14615	COG0514	ATP-dependent DNA helicase (RecQ)
SPH21_RS14630	COG1629	transport
SPH21_RS14635	COG0702	epimerase
SPH21_RS14645	COG0247	lactate metabolic process
SPH21_RS14670	COG1629	transport
SPH21_RS14675	COG0702	epimerase
SPH21_RS14680	COG4771	TonB-dependent receptor
SPH21_RS14695	COG0673	inositol 2-dehydrogenase activity
SPH21_RS14715	COG1629	transport
SPH21_RS14725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPH21_RS14750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPH21_RS14755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPH21_RS14760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPH21_RS14765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPH21_RS14770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPH21_RS14775	COG0633	Ferredoxin
SPH21_RS14780	COG0492	ferredoxin-NADP+ reductase activity
SPH21_RS14785	COG1846	Transcriptional regulator
SPH21_RS14790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPH21_RS14795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPH21_RS14800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SPH21_RS14820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPH21_RS14850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPH21_RS14855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SPH21_RS14870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SPH21_RS14885	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SPH21_RS14900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPH21_RS14910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SPH21_RS14920	COG0386	Belongs to the glutathione peroxidase family
SPH21_RS14930	COG1960	acyl-CoA dehydrogenase activity
SPH21_RS14940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SPH21_RS14945	COG0589	response to stress
SPH21_RS14950	COG0791	NLP P60 protein
SPH21_RS14955	COG1166	arginine decarboxylase activity
SPH21_RS14965	COG2235	arginine
SPH21_RS14970	COG0018	arginyl-trna synthetase
SPH21_RS14975	COG2111	Na H antiporter
SPH21_RS14975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPH21_RS14985	COG1006	Multisubunit Na H antiporter MnhC subunit
SPH21_RS14990	COG0651	ATP synthesis coupled electron transport
SPH21_RS15000	COG2212	antiporter activity
SPH21_RS15005	COG1320	monovalent cation:proton antiporter activity
SPH21_RS15010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPH21_RS15015	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPH21_RS15030	COG1104	cysteine desulfurase activity
SPH21_RS15040	COG0038	chloride channel
SPH21_RS15065	COG0456	acetyltransferase
SPH21_RS15115	COG1956	GAF domain-containing protein
SPH21_RS15125	COG0123	including yeast histone deacetylase and acetoin utilization protein
SPH21_RS15145	COG0254	rRNA binding
SPH21_RS15155	COG0149	triose-phosphate isomerase activity
SPH21_RS15160	COG2264	protein methyltransferase activity
SPH21_RS15190	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPH21_RS15195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPH21_RS15200	COG0791	NLP P60 protein
SPH21_RS15210	COG0305	Participates in initiation and elongation during chromosome replication
SPH21_RS15215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPH21_RS15220	COG2211	Major facilitator Superfamily
SPH21_RS15230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SPH21_RS15245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPH21_RS15255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPH21_RS15265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPH21_RS15270	COG1127	ABC transporter
SPH21_RS15280	COG1295	ribonuclease BN
SPH21_RS15300	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPH21_RS15305	COG0824	Thioesterase
SPH21_RS15310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SPH21_RS15335	COG1733	regulation of RNA biosynthetic process
SPH21_RS15340	COG0477	Major facilitator Superfamily
SPH21_RS15365	COG1185	polyribonucleotide nucleotidyltransferase activity
SPH21_RS15370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPH21_RS15375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPH21_RS15380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPH21_RS15395	COG0557	exoribonuclease II activity
SPH21_RS15405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPH21_RS15410	COG1611	Belongs to the LOG family
SPH21_RS15415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPH21_RS15420	COG0300	oxidoreductase activity
SPH21_RS15425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPH21_RS15430	COG0135	phosphoribosylanthranilate isomerase activity
SPH21_RS15435	COG0133	tryptophan synthase activity
SPH21_RS15440	COG0159	tryptophan synthase activity
SPH21_RS15450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPH21_RS15455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPH21_RS15460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS15465	COG0745	RESPONSE REGULATOR receiver
SPH21_RS15470	COG5002	protein histidine kinase activity
SPH21_RS15475	COG0564	pseudouridine synthase activity
SPH21_RS15480	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPH21_RS15495	COG0823	Involved in the tonB-independent uptake of proteins
SPH21_RS15505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPH21_RS15510	COG1668	transmembrane transport
SPH21_RS15515	COG4152	abc transporter atp-binding protein
SPH21_RS15525	COG0484	heat shock protein binding
SPH21_RS15530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPH21_RS15535	COG2884	Cell division ATP-binding protein ftsE
SPH21_RS15580	COG0012	GTP binding
SPH21_RS15585	COG1940	carbohydrate kinase activity
SPH21_RS15590	COG1629	transport
SPH21_RS15590	COG4206	TonB-dependent receptor
SPH21_RS15605	COG0539	negative regulation of cytoplasmic translation
SPH21_RS15610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPH21_RS15615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPH21_RS15635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SPH21_RS15640	COG0424	maF-like protein
SPH21_RS15650	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SPH21_RS15660	COG0475	glutathione-regulated potassium exporter activity
SPH21_RS15660	COG0589	response to stress
SPH21_RS15665	COG0538	isocitrate dehydrogenase activity
SPH21_RS15675	COG0784	Response regulator, receiver
SPH21_RS15675	COG2205	protein histidine kinase activity
SPH21_RS15680	COG0542	response to heat
SPH21_RS15690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPH21_RS15695	COG0494	nUDIX hydrolase
SPH21_RS15700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPH21_RS15720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPH21_RS15725	COG0069	glutamate synthase activity
SPH21_RS15730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SPH21_RS15740	COG1215	transferase activity, transferring glycosyl groups
SPH21_RS15755	COG1289	transmembrane transporter activity
SPH21_RS15760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPH21_RS15770	COG0673	inositol 2-dehydrogenase activity
SPH21_RS15780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPH21_RS15790	COG0527	aspartate kinase activity
SPH21_RS15795	COG0019	diaminopimelate decarboxylase activity
SPH21_RS15810	COG0482	sulfurtransferase activity
SPH21_RS15820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPH21_RS15825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPH21_RS15830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS15835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS15840	COG0492	ferredoxin-NADP+ reductase activity
SPH21_RS15845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPH21_RS15850	COG0069	glutamate synthase activity
SPH21_RS15850	COG0070	glutamate synthase
SPH21_RS15850	COG0067	glutamate synthase
SPH21_RS15875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPH21_RS15890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPH21_RS15895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPH21_RS15895	COG1648	precorrin-2 dehydrogenase activity
SPH21_RS15900	COG1648	precorrin-2 dehydrogenase activity
SPH21_RS15900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPH21_RS15905	COG0175	sulfate reduction
SPH21_RS15915	COG2895	sulfate adenylyltransferase (ATP) activity
SPH21_RS15930	COG0745	RESPONSE REGULATOR receiver
SPH21_RS15945	COG3118	belongs to the thioredoxin family
SPH21_RS15960	COG1162	GTPase activity
SPH21_RS16005	COG4585	Histidine kinase
SPH21_RS16010	COG0436	Aminotransferase
SPH21_RS16025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SPH21_RS16035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPH21_RS16040	COG1605	Chorismate mutase
SPH21_RS16040	COG0077	Prephenate dehydratase
SPH21_RS16045	COG0004	ammonium transporteR
SPH21_RS16060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPH21_RS16110	COG0590	tRNA wobble adenosine to inosine editing
SPH21_RS16120	COG0438	transferase activity, transferring glycosyl groups
SPH21_RS16125	COG0071	Belongs to the small heat shock protein (HSP20) family
SPH21_RS16185	COG4948	Mandelate Racemase Muconate Lactonizing
SPH21_RS16195	COG0326	Molecular chaperone. Has ATPase activity
SPH21_RS16205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPH21_RS16220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SPH21_RS16240	COG3876	Protein conserved in bacteria
SPH21_RS16250	COG4771	TonB-dependent receptor
SPH21_RS16260	COG1629	transport
SPH21_RS16275	COG1629	transport
SPH21_RS16275	COG4206	TonB-dependent receptor
SPH21_RS16280	COG1349	DNA-binding transcription factor activity
SPH21_RS16305	COG1196	nuclear chromosome segregation
SPH21_RS16315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPH21_RS16320	COG0436	Aminotransferase
SPH21_RS16330	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPH21_RS16335	COG1122	ATPase activity
SPH21_RS16340	COG1136	(ABC) transporter
SPH21_RS16360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPH21_RS16365	COG0492	ferredoxin-NADP+ reductase activity
SPH21_RS16370	COG2076	Multidrug Resistance protein
SPH21_RS16385	COG0602	queuosine metabolic process
SPH21_RS16390	COG0673	inositol 2-dehydrogenase activity
SPH21_RS16405	COG0328	RNA-DNA hybrid ribonuclease activity
SPH21_RS16420	COG1595	DNA-templated transcription, initiation
SPH21_RS16425	COG1301	dicarboxylic acid transport
SPH21_RS16440	COG1228	amidohydrolase
SPH21_RS16445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPH21_RS16450	COG2986	histidine ammonia-lyase
SPH21_RS16460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPH21_RS16465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPH21_RS16470	COG0367	asparagine synthase
SPH21_RS16475	COG1022	Amp-dependent synthetase and ligase
SPH21_RS16490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPH21_RS16500	COG0156	8-amino-7-oxononanoate synthase activity
SPH21_RS16510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPH21_RS16515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPH21_RS16565	COG2996	Protein conserved in bacteria
SPH21_RS16590	COG1696	Membrane protein involved in D-alanine export
SPH21_RS16610	COG2267	carboxylic ester hydrolase activity
SPH21_RS16615	COG0009	L-threonylcarbamoyladenylate synthase
SPH21_RS16620	COG0017	Asparaginyl-tRNA synthetase
SPH21_RS16625	COG0045	succinate-CoA ligase (ADP-forming) activity
SPH21_RS16630	COG1078	dGTPase activity
SPH21_RS16635	COG0649	NAD binding
SPH21_RS16640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPH21_RS16645	COG0259	pyridoxamine-phosphate oxidase activity
SPH21_RS16650	COG1678	Uncharacterized ACR, COG1678
SPH21_RS16670	COG1999	signal sequence binding
SPH21_RS16690	COG2814	Major facilitator Superfamily
SPH21_RS16715	COG2205	protein histidine kinase activity
SPH21_RS16720	COG0745	RESPONSE REGULATOR receiver
SPH21_RS16730	COG0408	coproporphyrinogen oxidase activity
SPH21_RS16750	COG0517	IMP dehydrogenase activity
SPH21_RS16750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SPH21_RS16755	COG0514	ATP-dependent DNA helicase (RecQ)
SPH21_RS16760	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SPH21_RS16765	COG1305	Transglutaminase-like
SPH21_RS16775	COG2308	Evidence 4 Homologs of previously reported genes of
SPH21_RS16810	COG0667	Aldo Keto reductase
SPH21_RS16820	COG0406	alpha-ribazole phosphatase activity
SPH21_RS16825	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPH21_RS16845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPH21_RS16850	COG0460	homoserine dehydrogenase
SPH21_RS16855	COG2081	HI0933 family
SPH21_RS16860	COG0673	inositol 2-dehydrogenase activity
SPH21_RS16875	COG3757	hydrolase, family 25
SPH21_RS16880	COG2890	protein-(glutamine-N5) methyltransferase activity
SPH21_RS16885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPH21_RS16885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPH21_RS16890	COG0697	spore germination
SPH21_RS16895	COG1739	Uncharacterized protein family UPF0029
SPH21_RS16905	COG2378	regulation of single-species biofilm formation
SPH21_RS16910	COG0456	acetyltransferase
SPH21_RS16915	COG2353	YceI-like domain
SPH21_RS16925	COG4774	siderophore transport
SPH21_RS16980	COG3279	Response regulator of the LytR AlgR family
SPH21_RS16990	COG1349	DNA-binding transcription factor activity
SPH21_RS17000	COG1136	(ABC) transporter
SPH21_RS17000	COG0577	efflux transmembrane transporter activity
SPH21_RS17005	COG1136	(ABC) transporter
SPH21_RS17010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS17020	COG3275	phosphorelay sensor kinase activity
SPH21_RS17025	COG3279	Response regulator of the LytR AlgR family
SPH21_RS17050	COG0667	Aldo Keto reductase
SPH21_RS17065	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SPH21_RS17075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPH21_RS17085	COG0587	DNA-directed DNA polymerase activity
SPH21_RS17095	COG1629	transport
SPH21_RS17125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPH21_RS17130	COG3621	Patatin-like phospholipase
SPH21_RS17135	COG2715	membrane protein required for spore maturation
SPH21_RS17145	COG1072	(Pantothenic acid kinase))
SPH21_RS17175	COG0481	GTPase activity
SPH21_RS17180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPH21_RS17190	COG3622	Belongs to the hyi family
SPH21_RS17195	COG1477	protein flavinylation
SPH21_RS17200	COG0673	inositol 2-dehydrogenase activity
SPH21_RS17205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPH21_RS17210	COG3189	MarR family transcriptional regulator
SPH21_RS17220	COG0582	viral genome integration into host DNA
SPH21_RS17310	COG1403	HNH endonuclease
SPH21_RS17335	COG0740	serine-type endopeptidase activity
SPH21_RS17475	COG0180	Tryptophanyl-tRNA synthetase
SPH21_RS17480	COG1428	Deoxynucleoside kinase
SPH21_RS17485	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SPH21_RS17495	COG1136	(ABC) transporter
SPH21_RS17505	COG0513	Belongs to the DEAD box helicase family
SPH21_RS17510	COG0504	CTP synthase activity
SPH21_RS17515	COG0706	membrane insertase activity
SPH21_RS17520	COG4191	Histidine kinase
SPH21_RS17540	COG2217	Heavy metal translocating P-type atpase
SPH21_RS17550	COG3278	Belongs to the heme-copper respiratory oxidase family
SPH21_RS17560	COG2010	Cytochrome c
SPH21_RS17565	COG0348	domain, Protein
SPH21_RS17590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPH21_RS17595	COG0167	dihydroorotate dehydrogenase activity
SPH21_RS17600	COG0488	(ABC) transporter
SPH21_RS17610	COG1607	acyl-coa hydrolase
SPH21_RS17620	COG1047	Peptidyl-prolyl cis-trans
SPH21_RS17625	COG1331	Highly conserved protein containing a thioredoxin domain
SPH21_RS17630	COG4948	Mandelate Racemase Muconate Lactonizing
SPH21_RS17640	COG0006	proline dipeptidase activity
SPH21_RS17645	COG3956	TIGRFAM MazG family protein
SPH21_RS17655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPH21_RS17665	COG0564	pseudouridine synthase activity
SPH21_RS17685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPH21_RS17685	COG3321	synthase
SPH21_RS17685	COG4221	oxidoreductase activity
SPH21_RS17685	COG0604	alcohol dehydrogenase
SPH21_RS17710	COG3385	transposase activity
SPH21_RS17850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPH21_RS17855	COG0730	response to heat
SPH21_RS17860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPH21_RS17860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPH21_RS17900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPH21_RS17910	COG1335	isochorismatase
SPH21_RS17925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPH21_RS17930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS17935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS17945	COG4232	protein-disulfide reductase activity
SPH21_RS17950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS17955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS17965	COG0551	DNA topoisomerase type I activity
SPH21_RS17965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPH21_RS18000	COG0823	Involved in the tonB-independent uptake of proteins
SPH21_RS18000	COG1506	peptidase
SPH21_RS18010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPH21_RS18030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SPH21_RS18035	COG0483	inositol monophosphate 1-phosphatase activity
SPH21_RS18040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPH21_RS18065	COG4771	TonB-dependent receptor
SPH21_RS18080	COG1024	Enoyl-CoA hydratase
SPH21_RS18095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS18120	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPH21_RS18125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPH21_RS18135	COG0673	inositol 2-dehydrogenase activity
SPH21_RS18145	COG2211	Major facilitator Superfamily
SPH21_RS18150	COG0517	IMP dehydrogenase activity
SPH21_RS18150	COG0516	GMP reductase activity
SPH21_RS18155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPH21_RS18190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPH21_RS18195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPH21_RS18225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPH21_RS18270	COG3422	double-strand break repair
SPH21_RS18285	COG0628	permease
SPH21_RS18290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPH21_RS18290	COG0551	DNA topoisomerase type I activity
SPH21_RS18300	COG1012	belongs to the aldehyde dehydrogenase family
SPH21_RS18310	COG0612	Peptidase, M16
SPH21_RS18315	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SPH21_RS18325	COG1253	flavin adenine dinucleotide binding
SPH21_RS18330	COG2169	Transcriptional regulator
SPH21_RS18350	COG3321	synthase
SPH21_RS18350	COG0604	alcohol dehydrogenase
SPH21_RS18355	COG0604	alcohol dehydrogenase
SPH21_RS18355	COG3321	synthase
SPH21_RS18360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPH21_RS18365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SPH21_RS18370	COG2814	Major facilitator Superfamily
SPH21_RS18385	COG3385	transposase activity
SPH21_RS18395	COG3409	Peptidoglycan-binding domain 1 protein
SPH21_RS18395	COG0793	Belongs to the peptidase S41A family
SPH21_RS18425	COG4206	TonB-dependent receptor
SPH21_RS18435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPH21_RS18440	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SPH21_RS18445	COG2207	Transcriptional regulator
SPH21_RS18455	COG2264	protein methyltransferase activity
SPH21_RS18460	COG0531	amino acid
SPH21_RS18490	COG2267	carboxylic ester hydrolase activity
SPH21_RS18495	COG3304	Inner membrane component domain
SPH21_RS18555	COG4221	oxidoreductase activity
SPH21_RS18570	COG3685	Protein conserved in bacteria
SPH21_RS18580	COG1546	Belongs to the CinA family
SPH21_RS18580	COG1058	Belongs to the CinA family
SPH21_RS18590	COG0315	cyclic pyranopterin monophosphate synthase activity
SPH21_RS18590	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPH21_RS18615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPH21_RS18625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SPH21_RS18630	COG1104	cysteine desulfurase activity
SPH21_RS18650	COG4585	Histidine kinase
SPH21_RS18665	COG2146	nitrite reductase [NAD(P)H] activity
SPH21_RS18665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPH21_RS18670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPH21_RS18670	COG1648	precorrin-2 dehydrogenase activity
SPH21_RS18675	COG1648	precorrin-2 dehydrogenase activity
SPH21_RS18675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPH21_RS18680	COG0303	'Molybdopterin
SPH21_RS18685	COG2223	nitrite transmembrane transporter activity
SPH21_RS18690	COG0243	molybdopterin cofactor binding
SPH21_RS18720	COG1132	(ABC) transporter
SPH21_RS18725	COG1132	(ABC) transporter
SPH21_RS18755	COG1131	(ABC) transporter
SPH21_RS18765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SPH21_RS18790	COG1285	pathogenesis
SPH21_RS18805	COG1113	amino acid transport
SPH21_RS18830	COG0300	oxidoreductase activity
SPH21_RS18835	COG0745	RESPONSE REGULATOR receiver
SPH21_RS18860	COG0697	spore germination
SPH21_RS18880	COG3685	Protein conserved in bacteria
SPH21_RS18930	COG0366	Alpha amylase catalytic
SPH21_RS18935	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS18950	COG4249	Peptidase C14 caspase catalytic subunit p20
SPH21_RS18970	COG2197	response regulator
SPH21_RS18975	COG2197	response regulator
SPH21_RS18995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPH21_RS19005	COG2192	nodulation
SPH21_RS19015	COG0859	PFAM glycosyl transferase family 9
SPH21_RS19020	COG0859	PFAM glycosyl transferase family 9
SPH21_RS19025	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPH21_RS19025	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SPH21_RS19030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SPH21_RS19065	COG4566	intracellular signal transduction
SPH21_RS19080	COG1063	alcohol dehydrogenase
SPH21_RS19095	COG0673	inositol 2-dehydrogenase activity
SPH21_RS19100	COG1349	DNA-binding transcription factor activity
SPH21_RS19105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPH21_RS19110	COG2223	nitrite transmembrane transporter activity
SPH21_RS19120	COG0277	FAD linked oxidase domain protein
SPH21_RS19120	COG0247	lactate metabolic process
SPH21_RS19125	COG2186	Transcriptional regulator
SPH21_RS19130	COG2223	nitrite transmembrane transporter activity
SPH21_RS19145	COG0475	glutathione-regulated potassium exporter activity
SPH21_RS19150	COG3279	Response regulator of the LytR AlgR family
SPH21_RS19160	COG0047	phosphoribosylformylglycinamidine synthase activity
SPH21_RS19160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPH21_RS19195	COG0420	3'-5' exonuclease activity
SPH21_RS19200	COG0730	response to heat
SPH21_RS19210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPH21_RS19215	COG1278	Cold shock
SPH21_RS19220	COG0450	alkyl hydroperoxide reductase
SPH21_RS19230	COG0321	lipoyl(octanoyl) transferase activity
SPH21_RS19230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPH21_RS19245	COG1674	ftsk spoiiie
SPH21_RS19260	COG0405	Gamma-glutamyltransferase
SPH21_RS19265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPH21_RS19270	COG0702	epimerase
SPH21_RS19275	COG4771	TonB-dependent receptor
SPH21_RS19290	COG0513	Belongs to the DEAD box helicase family
SPH21_RS19295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPH21_RS19300	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPH21_RS19310	COG0791	NLP P60 protein
SPH21_RS19315	COG1446	asparaginase
SPH21_RS19320	COG3142	Participates in the control of copper homeostasis
SPH21_RS19335	COG0205	6-phosphofructokinase activity
SPH21_RS19350	COG0307	riboflavin synthase, alpha
SPH21_RS19360	COG1609	Transcriptional regulator
SPH21_RS19370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPH21_RS19375	COG4206	TonB-dependent receptor
SPH21_RS19375	COG1629	transport
SPH21_RS19385	COG2366	antibiotic biosynthetic process
SPH21_RS19400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SPH21_RS19410	COG0531	amino acid
SPH21_RS19415	COG3158	transport of potassium into the cell
SPH21_RS19425	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPH21_RS19435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPH21_RS19445	COG3958	Transketolase
SPH21_RS19450	COG1595	DNA-templated transcription, initiation
SPH21_RS19465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPH21_RS19470	COG3118	belongs to the thioredoxin family
SPH21_RS19480	COG0745	RESPONSE REGULATOR receiver
SPH21_RS19480	COG2205	protein histidine kinase activity
SPH21_RS19480	COG3292	Two component regulator propeller
SPH21_RS19485	COG1501	Belongs to the glycosyl hydrolase 31 family
SPH21_RS19490	COG4771	TonB-dependent receptor
SPH21_RS19495	COG0702	epimerase
SPH21_RS19530	COG0039	L-malate dehydrogenase activity
SPH21_RS19540	COG0438	transferase activity, transferring glycosyl groups
SPH21_RS19540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPH21_RS19550	COG0438	transferase activity, transferring glycosyl groups
SPH21_RS19595	COG0667	Aldo Keto reductase
SPH21_RS19600	COG0545	Peptidyl-prolyl cis-trans isomerase
SPH21_RS19605	COG2723	6-phospho-beta-galactosidase activity
SPH21_RS19620	COG1418	mRNA catabolic process
SPH21_RS19645	COG2003	Belongs to the UPF0758 family
SPH21_RS19655	COG0268	Binds directly to 16S ribosomal RNA
SPH21_RS19665	COG4206	TonB-dependent receptor
SPH21_RS19680	COG1070	Carbohydrate kinase
SPH21_RS19685	COG1609	Transcriptional regulator
SPH21_RS19705	COG2239	Acts as a magnesium transporter
SPH21_RS19715	COG0659	secondary active sulfate transmembrane transporter activity
SPH21_RS19720	COG0288	reversible hydration of carbon dioxide
SPH21_RS19725	COG3781	membrane
SPH21_RS19735	COG5002	protein histidine kinase activity
SPH21_RS19740	COG0745	RESPONSE REGULATOR receiver
SPH21_RS19745	COG0051	transcription antitermination factor activity, RNA binding
SPH21_RS19750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPH21_RS19755	COG0049	tRNA binding
SPH21_RS19760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPH21_RS19765	COG0189	ligase activity
SPH21_RS19785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPH21_RS19795	COG0673	inositol 2-dehydrogenase activity
SPH21_RS19810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPH21_RS19815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPH21_RS19825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPH21_RS19830	COG1104	cysteine desulfurase activity
SPH21_RS19835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPH21_RS19845	COG0671	phosphoesterase, PA-phosphatase related
SPH21_RS19865	COG0237	dephospho-CoA kinase activity
SPH21_RS19875	COG1862	Preprotein translocase
SPH21_RS19885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPH21_RS19895	COG1132	(ABC) transporter
SPH21_RS19905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPH21_RS19915	COG2166	iron-sulfur cluster assembly
SPH21_RS19920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPH21_RS19925	COG0719	Fe-S assembly protein
SPH21_RS19930	COG0396	ATPase activity
SPH21_RS19935	COG0719	Fe-S assembly protein
SPH21_RS19940	COG0284	orotidine-5'-phosphate decarboxylase activity
SPH21_RS19950	COG1183	phosphatidylcholine synthase activity
SPH21_RS19955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPH21_RS19960	COG0616	signal peptide processing
SPH21_RS19965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPH21_RS19965	COG1796	DNA polymerase
SPH21_RS19990	COG0668	transmembrane transport
SPH21_RS19995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPH21_RS20015	COG0339	signal peptide processing
SPH21_RS20045	COG3385	transposase activity
SPH21_RS20070	COG3279	Response regulator of the LytR AlgR family
SPH21_RS20100	COG2363	Small membrane protein
SPH21_RS20105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPH21_RS20120	COG0392	lysyltransferase activity
SPH21_RS20120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SPH21_RS20125	COG0745	RESPONSE REGULATOR receiver
SPH21_RS20130	COG2205	protein histidine kinase activity
SPH21_RS20150	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SPH21_RS20160	COG0671	phosphoesterase, PA-phosphatase related
SPH21_RS20175	COG1764	response to oxidative stress
SPH21_RS20245	COG0842	Transport permease protein
SPH21_RS20245	COG1129	ABC transporter
SPH21_RS20250	COG0842	Transport permease protein
SPH21_RS20255	COG1131	(ABC) transporter
SPH21_RS20260	COG1131	(ABC) transporter
SPH21_RS20265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS20285	COG1484	DNA-dependent DNA replication
SPH21_RS20305	COG1278	Cold shock
SPH21_RS20330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPH21_RS20340	COG2755	lipolytic protein G-D-S-L family
SPH21_RS20340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SPH21_RS20360	COG0393	Putative heavy-metal-binding
SPH21_RS20380	COG1515	deoxyribonuclease V activity
SPH21_RS20400	COG1242	4 iron, 4 sulfur cluster binding
SPH21_RS20405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPH21_RS20425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPH21_RS20440	COG0189	ligase activity
SPH21_RS20460	COG4585	Histidine kinase
SPH21_RS20470	COG4953	penicillin-binding protein 1C
SPH21_RS20475	COG2373	Large extracellular alpha-helical protein
SPH21_RS20490	COG1045	serine acetyltransferase
SPH21_RS20495	COG1902	pentaerythritol trinitrate reductase activity
SPH21_RS20500	COG0640	Transcriptional regulator
SPH21_RS20520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPH21_RS20540	COG0726	polysaccharide deacetylase
SPH21_RS20575	COG2079	MmgE PrpD family protein
SPH21_RS20595	COG2814	Major facilitator Superfamily
SPH21_RS20600	COG0457	Tetratricopeptide repeat
SPH21_RS20610	COG0604	alcohol dehydrogenase
SPH21_RS20660	COG1733	regulation of RNA biosynthetic process
SPH21_RS20670	COG1484	DNA-dependent DNA replication
SPH21_RS20675	COG4584	PFAM Integrase catalytic
SPH21_RS20720	COG1595	DNA-templated transcription, initiation
SPH21_RS20750	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS20780	COG1733	regulation of RNA biosynthetic process
SPH21_RS20795	COG1733	regulation of RNA biosynthetic process
SPH21_RS20810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPH21_RS20820	COG4221	oxidoreductase activity
SPH21_RS20825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPH21_RS20840	COG4585	Histidine kinase
SPH21_RS20885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPH21_RS20890	COG3119	arylsulfatase activity
SPH21_RS20915	COG3279	Response regulator of the LytR AlgR family
SPH21_RS20965	COG4206	TonB-dependent receptor
SPH21_RS20965	COG1629	transport
SPH21_RS20995	COG3119	arylsulfatase activity
SPH21_RS21020	COG4771	TonB-dependent receptor
SPH21_RS21025	COG2814	Major facilitator Superfamily
SPH21_RS21030	COG2188	Transcriptional regulator
SPH21_RS21035	COG3537	Alpha-1,2-mannosidase
SPH21_RS21040	COG0702	epimerase
SPH21_RS21045	COG4771	TonB-dependent receptor
SPH21_RS21060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SPH21_RS21065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SPH21_RS21070	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SPH21_RS21080	COG2205	protein histidine kinase activity
SPH21_RS21085	COG5002	protein histidine kinase activity
SPH21_RS21100	COG4771	TonB-dependent receptor
SPH21_RS21120	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPH21_RS21140	COG2204	response regulator
SPH21_RS21150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SPH21_RS21155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPH21_RS21155	COG2169	Transcriptional regulator
SPH21_RS21160	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SPH21_RS21160	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SPH21_RS21165	COG0024	Methionine aminopeptidase
SPH21_RS21170	COG0698	ribose 5-phosphate isomerase
SPH21_RS21175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPH21_RS21180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPH21_RS21185	COG0363	glucosamine-6-phosphate deaminase activity
SPH21_RS21225	COG2814	Major facilitator Superfamily
SPH21_RS21235	COG4585	Histidine kinase
SPH21_RS21240	COG0702	epimerase
SPH21_RS21245	COG4771	TonB-dependent receptor
SPH21_RS21270	COG2239	Acts as a magnesium transporter
SPH21_RS21285	COG1999	signal sequence binding
SPH21_RS21330	COG4771	TonB-dependent receptor
SPH21_RS21355	COG0577	efflux transmembrane transporter activity
SPH21_RS21360	COG3119	arylsulfatase activity
SPH21_RS21365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPH21_RS21375	COG4941	Belongs to the sigma-70 factor family
SPH21_RS21380	COG3119	arylsulfatase activity
SPH21_RS21395	COG2249	NAD(P)H dehydrogenase (quinone) activity
SPH21_RS21430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPH21_RS21450	COG4771	TonB-dependent receptor
SPH21_RS21510	COG0583	DNA-binding transcription factor activity
SPH21_RS21540	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SPH21_RS21555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPH21_RS21580	COG1309	transcriptional regulator
SPH21_RS21585	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS21595	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS21615	COG0519	Catalyzes the synthesis of GMP from XMP
SPH21_RS21635	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS21655	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS21660	COG3275	phosphorelay sensor kinase activity
SPH21_RS21665	COG3279	Response regulator of the LytR AlgR family
SPH21_RS21695	COG0778	Nitroreductase
SPH21_RS21700	COG1733	regulation of RNA biosynthetic process
SPH21_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS21720	COG1136	(ABC) transporter
SPH21_RS21720	COG0577	efflux transmembrane transporter activity
SPH21_RS21725	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS21770	COG4221	oxidoreductase activity
SPH21_RS21805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPH21_RS21810	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS21825	COG5433	transposase activity
SPH21_RS21840	COG4771	TonB-dependent receptor
SPH21_RS21845	COG0702	epimerase
SPH21_RS21855	COG1620	l-lactate permease
SPH21_RS21860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH21_RS21870	COG1484	DNA-dependent DNA replication
SPH21_RS21875	COG4584	PFAM Integrase catalytic
SPH21_RS21930	COG1132	(ABC) transporter
SPH21_RS21935	COG1132	(ABC) transporter
SPH21_RS21935	COG2375	cellular response to nickel ion
SPH21_RS22010	COG3250	beta-galactosidase activity
SPH21_RS22030	COG1733	regulation of RNA biosynthetic process
SPH21_RS22070	COG3940	Belongs to the glycosyl hydrolase 43 family
SPH21_RS22075	COG3119	arylsulfatase activity
SPH21_RS22085	COG1629	transport
SPH21_RS22135	COG3279	Response regulator of the LytR AlgR family
SPH21_RS22145	COG1278	Cold shock
SPH21_RS22150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPH21_RS22190	COG0586	Pfam SNARE associated Golgi protein
SPH21_RS22195	COG3275	phosphorelay sensor kinase activity
SPH21_RS22205	COG3279	Response regulator of the LytR AlgR family
SPH21_RS22215	COG4221	oxidoreductase activity
SPH21_RS22225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SPH21_RS22235	COG0352	thiamine-phosphate diphosphorylase activity
SPH21_RS22235	COG0351	phosphomethylpyrimidine kinase
SPH21_RS22240	COG3250	beta-galactosidase activity
SPH21_RS22325	COG4106	trans-aconitate 2-methyltransferase activity
SPH21_RS22335	COG0708	Exodeoxyribonuclease III
SPH21_RS22375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPH21_RS22380	COG0581	inorganic phosphate transmembrane transporter activity
SPH21_RS22385	COG0573	inorganic phosphate transmembrane transporter activity
SPH21_RS22390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPH21_RS22410	COG1464	Belongs to the NlpA lipoprotein family
SPH21_RS22415	COG2011	ABC-type metal ion transport system permease component
SPH21_RS22430	COG1506	peptidase
SPH21_RS22430	COG4946	Tricorn protease homolog
SPH21_RS22430	COG0823	Involved in the tonB-independent uptake of proteins
SPH21_RS22440	COG1629	transport
SPH21_RS22515	COG3119	arylsulfatase activity
SPH21_RS22530	COG3537	Alpha-1,2-mannosidase
SPH21_RS22555	COG3537	Alpha-1,2-mannosidase
SPH21_RS22560	COG3250	beta-galactosidase activity
SPH21_RS22600	COG2133	pyrroloquinoline quinone binding
SPH21_RS22610	COG2353	YceI-like domain
SPH21_RS22620	COG4948	Mandelate Racemase Muconate Lactonizing
SPH21_RS22625	COG2271	Major facilitator Superfamily
SPH21_RS22630	COG3734	2-keto-3-deoxy-galactonokinase
SPH21_RS22635	COG2271	Major facilitator Superfamily
SPH21_RS22645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPH21_RS22665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPH21_RS22675	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS22740	COG2814	Major facilitator Superfamily
SPH21_RS22755	COG0024	Methionine aminopeptidase
SPH21_RS22760	COG1309	transcriptional regulator
SPH21_RS22800	COG3385	transposase activity
SPH21_RS22825	COG0629	single-stranded DNA binding
SPH21_RS22840	COG1929	Belongs to the glycerate kinase type-1 family
SPH21_RS22860	COG1309	transcriptional regulator
SPH21_RS22865	COG3590	peptidase
SPH21_RS22870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPH21_RS22875	COG5433	transposase activity
SPH21_RS22885	COG3279	Response regulator of the LytR AlgR family
SPH21_RS22915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPH21_RS22920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPH21_RS22920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SPH21_RS22930	COG0626	cystathionine gamma-synthase activity
SPH21_RS22935	COG0442	prolyl-tRNA aminoacylation
SPH21_RS22985	COG0783	Belongs to the Dps family
SPH21_RS22990	COG1030	water channel activity
SPH21_RS23000	COG0791	NLP P60 protein
SPH21_RS23000	COG1388	LysM domain
SPH21_RS23005	COG0572	uridine kinase
SPH21_RS23020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPH21_RS23025	COG1193	negative regulation of DNA recombination
SPH21_RS23035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPH21_RS23050	COG0527	aspartate kinase activity
SPH21_RS23090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPH21_RS23130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPH21_RS23165	COG4771	TonB-dependent receptor
SPH21_RS23170	COG0702	epimerase
SPH21_RS23175	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPH21_RS23185	COG1063	alcohol dehydrogenase
SPH21_RS23210	COG1629	transport
SPH21_RS23210	COG4206	TonB-dependent receptor
SPH21_RS23215	COG0561	phosphatase activity
SPH21_RS23230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPH21_RS23255	COG0745	RESPONSE REGULATOR receiver
SPH21_RS23280	COG0702	epimerase
SPH21_RS23285	COG4771	TonB-dependent receptor
SPH21_RS23300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPH21_RS23325	COG2197	response regulator
SPH21_RS23330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SPH21_RS23335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPH21_RS23340	COG0581	inorganic phosphate transmembrane transporter activity
SPH21_RS23345	COG0573	inorganic phosphate transmembrane transporter activity
SPH21_RS23360	COG5002	protein histidine kinase activity
SPH21_RS23390	COG3275	phosphorelay sensor kinase activity
SPH21_RS23395	COG3279	Response regulator of the LytR AlgR family
SPH21_RS23400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPH21_RS23410	COG1629	transport
SPH21_RS23410	COG4206	TonB-dependent receptor
SPH21_RS23430	COG3059	membrane
SPH21_RS23450	COG2010	Cytochrome c
SPH21_RS23450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPH21_RS23460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS23465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS23470	COG1629	transport
SPH21_RS23475	COG0702	epimerase
SPH21_RS23480	COG3119	arylsulfatase activity
SPH21_RS23495	COG4221	oxidoreductase activity
SPH21_RS23505	COG0110	maltose O-acetyltransferase activity
SPH21_RS23515	COG4221	oxidoreductase activity
SPH21_RS23565	COG0798	PFAM Bile acid sodium symporter
SPH21_RS23570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPH21_RS23590	COG1621	beta-fructofuranosidase activity
SPH21_RS23605	COG1064	alcohol dehydrogenase
SPH21_RS23610	COG1917	Cupin 2, conserved barrel domain protein
SPH21_RS23610	COG4977	sequence-specific DNA binding
SPH21_RS23615	COG1733	regulation of RNA biosynthetic process
SPH21_RS23635	COG2814	Major facilitator Superfamily
SPH21_RS23655	COG1629	transport
SPH21_RS23660	COG1609	Transcriptional regulator
SPH21_RS23665	COG5002	protein histidine kinase activity
SPH21_RS23680	COG4771	TonB-dependent receptor
SPH21_RS23715	COG0456	acetyltransferase
SPH21_RS23745	COG3279	Response regulator of the LytR AlgR family
SPH21_RS23750	COG3177	Filamentation induced by cAMP protein fic
SPH21_RS23765	COG1733	regulation of RNA biosynthetic process
SPH21_RS23770	COG2267	carboxylic ester hydrolase activity
SPH21_RS23775	COG2207	Transcriptional regulator
SPH21_RS23785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPH21_RS23820	COG2205	protein histidine kinase activity
SPH21_RS23820	COG0745	RESPONSE REGULATOR receiver
SPH21_RS23820	COG3292	Two component regulator propeller
SPH21_RS23920	COG0519	Catalyzes the synthesis of GMP from XMP
SPH21_RS23945	COG1902	pentaerythritol trinitrate reductase activity
SPH21_RS23970	COG1629	transport
SPH21_RS23975	COG0702	epimerase
SPH21_RS24005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPH21_RS24010	COG3708	Transcriptional regulator
SPH21_RS24010	COG2207	Transcriptional regulator
SPH21_RS24015	COG4221	oxidoreductase activity
SPH21_RS24030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPH21_RS24070	COG0494	nUDIX hydrolase
SPH21_RS24075	COG3604	Transcriptional regulator
SPH21_RS24090	COG3279	Response regulator of the LytR AlgR family
SPH21_RS24095	COG3604	Transcriptional regulator
SPH21_RS24105	COG0657	acetylesterase activity
SPH21_RS24110	COG3604	Transcriptional regulator
SPH21_RS24120	COG1733	regulation of RNA biosynthetic process
SPH21_RS24140	COG2207	Transcriptional regulator
SPH21_RS24150	COG1538	Outer membrane efflux protein
SPH21_RS24170	COG4977	sequence-specific DNA binding
SPH21_RS24170	COG1917	Cupin 2, conserved barrel domain protein
SPH21_RS24250	COG4771	TonB-dependent receptor
SPH21_RS24255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS24280	COG5290	Psort location Cytoplasmic, score
SPH21_RS24360	COG1484	DNA-dependent DNA replication
SPH21_RS24375	COG0515	serine threonine protein kinase
SPH21_RS24400	COG1484	DNA-dependent DNA replication
SPH21_RS24405	COG4584	PFAM Integrase catalytic
SPH21_RS24510	COG3385	transposase activity
SPH21_RS24530	COG0577	efflux transmembrane transporter activity
SPH21_RS24560	COG1917	Cupin 2, conserved barrel domain protein
SPH21_RS24560	COG2207	Transcriptional regulator
SPH21_RS24565	COG0300	oxidoreductase activity
SPH21_RS24570	COG4221	oxidoreductase activity
SPH21_RS24610	COG0456	acetyltransferase
SPH21_RS24620	COG1137	ATPase activity
SPH21_RS24625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPH21_RS24645	COG1733	regulation of RNA biosynthetic process
SPH21_RS24650	COG2814	Major facilitator Superfamily
SPH21_RS24665	COG0667	Aldo Keto reductase
SPH21_RS24705	COG1473	amidohydrolase
SPH21_RS24720	COG4771	TonB-dependent receptor
SPH21_RS24755	COG0640	Transcriptional regulator
SPH21_RS24800	COG1028	Short-chain dehydrogenase reductase Sdr
SPH21_RS24805	COG1690	Belongs to the RtcB family
SPH21_RS24830	COG1858	cytochrome C peroxidase
SPH21_RS24880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPH21_RS24905	COG3119	arylsulfatase activity
SPH21_RS24915	COG0702	epimerase
SPH21_RS24920	COG4771	TonB-dependent receptor
SPH21_RS24930	COG0745	RESPONSE REGULATOR receiver
SPH21_RS24930	COG2205	protein histidine kinase activity
SPH21_RS24930	COG3292	Two component regulator propeller
SPH21_RS24930	COG0745	RESPONSE REGULATOR receiver
SPH21_RS24930	COG2205	protein histidine kinase activity
SPH21_RS24930	COG3292	Two component regulator propeller
SPH21_RS24945	COG4774	siderophore transport
SPH21_RS24955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPH21_RS25000	COG0753	catalase activity
SPH21_RS25005	COG3685	Protein conserved in bacteria
SPH21_RS25040	COG0702	epimerase
SPH21_RS25045	COG4771	TonB-dependent receptor
SPH21_RS25080	COG0673	inositol 2-dehydrogenase activity
SPH21_RS25085	COG4335	DNA alkylation repair
SPH21_RS25115	COG1846	Transcriptional regulator
SPH21_RS25125	COG2808	Putative FMN-binding domain
SPH21_RS25135	COG4771	TonB-dependent receptor
SPH21_RS25145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPH21_RS25150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPH21_RS25170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SPH21_RS25180	COG0837	glucose binding
SPH21_RS25200	COG1629	transport
SPH21_RS25205	COG0702	epimerase
SPH21_RS25210	COG4771	TonB-dependent receptor
SPH21_RS25215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPH21_RS25220	COG2610	gluconate transmembrane transporter activity
SPH21_RS25235	COG4895	conserved protein (DUF2196)
SPH21_RS25245	COG1366	Belongs to the anti-sigma-factor antagonist family
SPH21_RS25245	COG2202	Pas domain
SPH21_RS25250	COG0745	RESPONSE REGULATOR receiver
SPH21_RS25255	COG0463	Glycosyl transferase, family 2
SPH21_RS25255	COG1216	Glycosyl transferase, family 2
SPH21_RS25260	COG0463	Glycosyl transferase, family 2
SPH21_RS25275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPH21_RS25280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPH21_RS25285	COG0297	glycogen (starch) synthase activity
SPH21_RS25290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPH21_RS25305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPH21_RS25310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPH21_RS25315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPH21_RS25320	COG0131	Imidazoleglycerol-phosphate dehydratase
SPH21_RS25330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPH21_RS25335	COG0107	imidazoleglycerol-phosphate synthase activity
SPH21_RS25340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SPH21_RS25340	COG0140	phosphoribosyl-ATP diphosphatase activity
SPH21_RS25360	COG1393	Belongs to the ArsC family
SPH21_RS25365	COG0193	aminoacyl-tRNA hydrolase activity
SPH21_RS25370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SPH21_RS25375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPH21_RS25410	COG4221	oxidoreductase activity
SPH21_RS25420	COG0629	single-stranded DNA binding
SPH21_RS25435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPH21_RS25455	COG4771	TonB-dependent receptor
SPH21_RS25460	COG0702	epimerase
SPH21_RS25465	COG3119	arylsulfatase activity
SPH21_RS25475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SPH21_RS25485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SPH21_RS25490	COG3237	CsbD-like
SPH21_RS25495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPH21_RS25510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPH21_RS25515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPH21_RS25525	COG0552	protein localization to endoplasmic reticulum
SPH21_RS25530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPH21_RS25535	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SPH21_RS25550	COG1981	membrane
SPH21_RS25555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPH21_RS25565	COG0745	RESPONSE REGULATOR receiver
SPH21_RS25570	COG5002	protein histidine kinase activity
SPH21_RS25575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPH21_RS25580	COG0113	porphobilinogen synthase activity
SPH21_RS25585	COG0181	hydroxymethylbilane synthase activity
SPH21_RS25590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SPH21_RS25605	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPH21_RS25610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPH21_RS25620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SPH21_RS25625	COG0517	IMP dehydrogenase activity
SPH21_RS25625	COG0516	GMP reductase activity
SPH21_RS25630	COG2267	carboxylic ester hydrolase activity
SPH21_RS25635	COG1610	YqeY-like protein
SPH21_RS25640	COG4221	oxidoreductase activity
SPH21_RS25650	COG2226	methyltransferase
SPH21_RS25655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SPH21_RS25695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPH21_RS25700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPH21_RS25710	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPH21_RS25720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPH21_RS25720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPH21_RS25740	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPH21_RS25750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPH21_RS25755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SPH21_RS25760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPH21_RS25765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SPH21_RS25770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPH21_RS25775	COG0356	it plays a direct role in the translocation of protons across the membrane
SPH21_RS25795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPH21_RS25795	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPH21_RS25800	COG0322	excinuclease ABC activity
SPH21_RS25810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPH21_RS25825	COG1012	belongs to the aldehyde dehydrogenase family
SPH21_RS25835	COG2267	carboxylic ester hydrolase activity
SPH21_RS25840	COG1363	Peptidase, m42
SPH21_RS25845	COG2814	Major facilitator Superfamily
SPH21_RS25855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPH21_RS25875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPH21_RS25885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPH21_RS25895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPH21_RS25915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPH21_RS25920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPH21_RS25920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SPH21_RS25925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPH21_RS25930	COG0490	domain, Protein
SPH21_RS25935	COG0475	glutathione-regulated potassium exporter activity
SPH21_RS25940	COG1285	pathogenesis
SPH21_RS25945	COG2151	metal-sulfur cluster biosynthetic enzyme
SPH21_RS25950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPH21_RS25960	COG1187	pseudouridine synthase activity
SPH21_RS26010	COG0784	Response regulator, receiver
SPH21_RS26010	COG2198	Histidine kinase
SPH21_RS26010	COG5002	protein histidine kinase activity
SPH21_RS26020	COG0702	epimerase
SPH21_RS26045	COG2972	Histidine kinase
SPH21_RS26070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS26075	COG2972	Histidine kinase
SPH21_RS26110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPH21_RS26140	COG1570	exodeoxyribonuclease VII activity
SPH21_RS26155	COG1216	Glycosyl transferase, family 2
SPH21_RS26160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPH21_RS26170	COG1215	transferase activity, transferring glycosyl groups
SPH21_RS26195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPH21_RS26215	COG5002	protein histidine kinase activity
SPH21_RS26255	COG1864	DNA RNA non-specific endonuclease
SPH21_RS26255	COG3591	Belongs to the peptidase S1B family
SPH21_RS26265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPH21_RS26305	COG1863	multisubunit Na H antiporter MnhE subunit
SPH21_RS26345	COG2885	chlorophyll binding
SPH21_RS26395	COG0784	Response regulator, receiver
SPH21_RS26395	COG2205	protein histidine kinase activity
SPH21_RS26435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPH21_RS26445	COG2972	Histidine kinase