SPH21_RS17210 604c80f5834b814aa383d7d48ecc0eaf 117 Pfam PF04343 Protein of unknown function, DUF488 5 113 3.4E-32 T 21-04-2016 IPR007438 Protein of unknown function DUF488 SPH21_RS17210 604c80f5834b814aa383d7d48ecc0eaf 117 PANTHER PTHR36849 1 117 1.3E-44 T 21-04-2016 SPH21_RS17210 604c80f5834b814aa383d7d48ecc0eaf 117 PANTHER PTHR36849:SF1 1 117 1.3E-44 T 21-04-2016 SPH21_RS04575 79ec5d66ec388292c050859f03a9527d 460 Pfam PF13347 MFS/sugar transport protein 9 444 2.9E-106 T 21-04-2016 SPH21_RS04575 79ec5d66ec388292c050859f03a9527d 460 SUPERFAMILY SSF103473 9 439 8.63E-42 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS04575 79ec5d66ec388292c050859f03a9527d 460 PANTHER PTHR11328 2 460 9.1E-129 T 21-04-2016 SPH21_RS04575 79ec5d66ec388292c050859f03a9527d 460 Gene3D G3DSA:1.20.1250.20 16 210 4.0E-13 T 21-04-2016 SPH21_RS04575 79ec5d66ec388292c050859f03a9527d 460 Gene3D G3DSA:1.20.1250.20 222 441 1.5E-19 T 21-04-2016 SPH21_RS04575 79ec5d66ec388292c050859f03a9527d 460 TIGRFAM TIGR00792 gph: sugar (Glycoside-Pentoside-Hexuronide) transporter 8 455 3.9E-116 T 21-04-2016 IPR001927 Sodium:galactoside symporter GO:0005215|GO:0006814|GO:0016020 SPH21_RS04575 79ec5d66ec388292c050859f03a9527d 460 PANTHER PTHR11328:SF24 2 460 9.1E-129 T 21-04-2016 SPH21_RS10080 255881847ef39cc25e9c23a94d992942 374 SUPERFAMILY SSF69572 100 319 3.92E-24 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS10080 255881847ef39cc25e9c23a94d992942 374 Gene3D G3DSA:3.40.50.720 108 248 2.6E-18 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10080 255881847ef39cc25e9c23a94d992942 374 Pfam PF00899 ThiF family 110 249 1.6E-17 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 SUPERFAMILY SSF56524 64 304 7.98E-64 T 21-04-2016 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 TIGRFAM TIGR04555 sulfite_DH_soxC: sulfite dehydrogenase 52 394 3.1E-145 T 21-04-2016 IPR030835 Sulfite dehydrogenase SoxC SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 PANTHER PTHR19372:SF2 71 394 1.4E-71 T 21-04-2016 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 Gene3D G3DSA:3.90.420.10 68 272 2.5E-58 T 21-04-2016 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 Pfam PF00174 Oxidoreductase molybdopterin binding domain 91 249 1.1E-45 T 21-04-2016 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 PANTHER PTHR19372 71 394 1.4E-71 T 21-04-2016 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 Pfam PF03404 Mo-co oxidoreductase dimerisation domain 272 364 6.6E-12 T 21-04-2016 IPR005066 Moybdenum cofactor oxidoreductase, dimerisation GO:0016491|GO:0030151|GO:0055114 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 SUPERFAMILY SSF81296 274 388 1.4E-26 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 PRINTS PR00407 Eukaryotic molybdopterin domain signature 216 229 1.6E-19 T 21-04-2016 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 PRINTS PR00407 Eukaryotic molybdopterin domain signature 199 215 1.6E-19 T 21-04-2016 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 PRINTS PR00407 Eukaryotic molybdopterin domain signature 79 95 1.6E-19 T 21-04-2016 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 PRINTS PR00407 Eukaryotic molybdopterin domain signature 309 321 1.6E-19 T 21-04-2016 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 PRINTS PR00407 Eukaryotic molybdopterin domain signature 232 245 1.6E-19 T 21-04-2016 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 SPH21_RS23260 7fb5e21b3b783905a31d4d58fb2e4ca5 400 Gene3D G3DSA:2.60.40.650 274 389 9.7E-25 T 21-04-2016 IPR005066 Moybdenum cofactor oxidoreductase, dimerisation GO:0016491|GO:0030151|GO:0055114 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 PANTHER PTHR24221:SF138 7 592 4.4E-89 T 21-04-2016 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 Pfam PF00664 ABC transporter transmembrane region 29 294 5.5E-16 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 SMART SM00382 374 560 5.1E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 ProSitePatterns PS00211 ABC transporters family signature. 484 498 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 Gene3D G3DSA:1.20.1560.10 13 316 5.0E-32 T 21-04-2016 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 Gene3D G3DSA:3.40.50.300 344 589 9.9E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 SUPERFAMILY SSF52540 347 584 2.41E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 SUPERFAMILY SSF90123 13 307 2.49E-35 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 SUPERFAMILY SSF90123 488 494 2.49E-35 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 PANTHER PTHR24221 7 592 4.4E-89 T 21-04-2016 SPH21_RS04465 a6a20765bb9497eeef8133e265ae6b87 592 Pfam PF00005 ABC transporter 365 514 7.1E-25 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS18275 bd2ab6f719b2ff2c28d78392020b6e45 369 Gene3D G3DSA:1.20.140.10 200 359 4.2E-14 T 21-04-2016 SPH21_RS18275 bd2ab6f719b2ff2c28d78392020b6e45 369 Gene3D G3DSA:2.40.110.10 109 199 1.8E-15 T 21-04-2016 SPH21_RS18275 bd2ab6f719b2ff2c28d78392020b6e45 369 PIRSF PIRSF016578 1 368 1.5E-53 T 21-04-2016 SPH21_RS18275 bd2ab6f719b2ff2c28d78392020b6e45 369 Gene3D G3DSA:1.10.540.10 3 100 1.1E-18 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS18275 bd2ab6f719b2ff2c28d78392020b6e45 369 SUPERFAMILY SSF56645 6 201 1.09E-17 T 21-04-2016 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SPH21_RS18275 bd2ab6f719b2ff2c28d78392020b6e45 369 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 232 360 2.0E-9 T 21-04-2016 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 435 549 2.4E-26 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 SMART SM00388 322 387 1.5E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 SUPERFAMILY SSF47384 313 387 1.2E-17 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 PRINTS PR00344 Bacterial sensor protein C-terminal signature 510 528 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 PRINTS PR00344 Bacterial sensor protein C-terminal signature 477 491 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 PRINTS PR00344 Bacterial sensor protein C-terminal signature 495 505 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 PRINTS PR00344 Bacterial sensor protein C-terminal signature 534 547 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 Gene3D G3DSA:3.30.565.10 402 548 1.3E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 PANTHER PTHR24423 138 153 1.4E-77 T 21-04-2016 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 PANTHER PTHR24423 320 548 1.4E-77 T 21-04-2016 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 Pfam PF00512 His Kinase A (phospho-acceptor) domain 323 386 1.2E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 SMART SM00387 435 550 6.0E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 SUPERFAMILY SSF55874 376 548 6.42E-40 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10240 6e989dc9e5367901110d5ce8df9381d8 553 Gene3D G3DSA:1.10.287.130 318 383 1.1E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 Pfam PF00884 Sulfatase 33 403 4.1E-60 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 Gene3D G3DSA:3.40.720.10 30 253 1.3E-114 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 Gene3D G3DSA:3.40.720.10 291 421 1.3E-114 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 SUPERFAMILY SSF53649 31 265 3.53E-119 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 SUPERFAMILY SSF53649 303 508 3.53E-119 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 ProSitePatterns PS00523 Sulfatases signature 1. 79 91 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 Gene3D G3DSA:3.30.1120.10 433 509 8.9E-20 T 21-04-2016 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 PANTHER PTHR10342:SF237 294 508 1.7E-164 T 21-04-2016 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 PANTHER PTHR10342:SF237 5 230 1.7E-164 T 21-04-2016 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 Pfam PF16347 Domain of unknown function (DUF4976) 405 508 8.0E-40 T 21-04-2016 IPR032506 Domain of unknown function DUF4976 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 PANTHER PTHR10342 294 508 1.7E-164 T 21-04-2016 SPH21_RS21380 03cb788aff659b25287d7496009b66bc 519 PANTHER PTHR10342 5 230 1.7E-164 T 21-04-2016 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 Pfam PF00551 Formyl transferase 83 260 5.7E-44 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PANTHER PTHR10520 1 272 1.8E-107 T 21-04-2016 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 Hamap MF_01927 Formyltetrahydrofolate deformylase [purU]. 1 278 41.242 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 TIGRFAM TIGR00655 PurU: formyltetrahydrofolate deformylase 6 278 2.3E-104 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PANTHER PTHR10520:SF7 1 272 1.8E-107 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 Gene3D G3DSA:3.40.50.170 83 278 3.2E-54 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 38 50 8.5E-51 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 252 277 8.5E-51 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 230 252 8.5E-51 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 84 106 8.5E-51 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 6 32 8.5E-51 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 106 133 8.5E-51 T 21-04-2016 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00074 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 SUPERFAMILY SSF53328 83 279 3.53E-59 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 PIRSF PIRSF036480 1 279 3.0E-102 T 21-04-2016 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 SUPERFAMILY SSF55021 3 67 5.41E-9 T 21-04-2016 SPH21_RS08145 0ac83a923e625bedd89b52ef48f81587 279 Gene3D G3DSA:3.30.70.260 1 65 6.1E-10 T 21-04-2016 SPH21_RS25260 51bb2350ec407a7a4fb4c5eaece7f1be 316 SUPERFAMILY SSF53448 1 264 1.5E-44 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS25260 51bb2350ec407a7a4fb4c5eaece7f1be 316 PANTHER PTHR10859:SF100 2 316 1.9E-154 T 21-04-2016 SPH21_RS25260 51bb2350ec407a7a4fb4c5eaece7f1be 316 PANTHER PTHR10859 2 316 1.9E-154 T 21-04-2016 SPH21_RS25260 51bb2350ec407a7a4fb4c5eaece7f1be 316 Gene3D G3DSA:3.90.550.10 1 174 6.0E-29 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS25260 51bb2350ec407a7a4fb4c5eaece7f1be 316 Pfam PF00535 Glycosyl transferase family 2 4 167 5.6E-28 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS05460 c8f51252285811fc01a244537a9c3bd5 216 Pfam PF00149 Calcineurin-like phosphoesterase 29 131 9.3E-9 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS05460 c8f51252285811fc01a244537a9c3bd5 216 PANTHER PTHR39323:SF1 6 196 5.5E-26 T 21-04-2016 SPH21_RS05460 c8f51252285811fc01a244537a9c3bd5 216 Gene3D G3DSA:3.60.21.10 29 161 3.8E-11 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS05460 c8f51252285811fc01a244537a9c3bd5 216 PIRSF PIRSF000887 7 215 2.9E-37 T 21-04-2016 IPR024173 Phosphoesterase, MJ0037 SPH21_RS05460 c8f51252285811fc01a244537a9c3bd5 216 SUPERFAMILY SSF56300 30 166 2.48E-15 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS05460 c8f51252285811fc01a244537a9c3bd5 216 TIGRFAM TIGR04123 P_estr_lig_assc: metallophosphoesterase, DNA ligase-associated 8 213 1.2E-56 T 21-04-2016 IPR026336 Metallophosphoesterase, DNA ligase-associated SPH21_RS05460 c8f51252285811fc01a244537a9c3bd5 216 PANTHER PTHR39323 6 196 5.5E-26 T 21-04-2016 SPH21_RS04925 91f0f6bd9f5c0cdd283ef0bf880fdf56 478 Gene3D G3DSA:1.25.40.10 219 414 1.4E-23 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04925 91f0f6bd9f5c0cdd283ef0bf880fdf56 478 SUPERFAMILY SSF48452 20 471 1.33E-81 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04925 91f0f6bd9f5c0cdd283ef0bf880fdf56 478 Pfam PF14322 Starch-binding associating with outer membrane 24 236 3.2E-23 T 21-04-2016 SPH21_RS04925 91f0f6bd9f5c0cdd283ef0bf880fdf56 478 Pfam PF07980 SusD family 341 471 3.6E-15 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13730 52ac6297ea0cee110896f2734fa14b4f 118 SUPERFAMILY SSF46785 15 112 4.23E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13730 52ac6297ea0cee110896f2734fa14b4f 118 Gene3D G3DSA:1.10.10.10 6 114 2.7E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13730 52ac6297ea0cee110896f2734fa14b4f 118 Pfam PF01638 HxlR-like helix-turn-helix 27 112 1.2E-22 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS13730 52ac6297ea0cee110896f2734fa14b4f 118 PANTHER PTHR33204 6 115 1.3E-21 T 21-04-2016 SPH21_RS26485 9046828061ed28dd194fd914c0eece40 312 Pfam PF16344 Domain of unknown function (DUF4974) 202 300 3.5E-9 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS26485 9046828061ed28dd194fd914c0eece40 312 Pfam PF04773 FecR protein 93 186 2.5E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS26485 9046828061ed28dd194fd914c0eece40 312 PANTHER PTHR30273 1 308 5.6E-38 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26485 9046828061ed28dd194fd914c0eece40 312 PIRSF PIRSF018266 2 308 1.8E-44 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26485 9046828061ed28dd194fd914c0eece40 312 PANTHER PTHR30273:SF2 1 308 5.6E-38 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Pfam PF07494 Two component regulator propeller 259 281 1.6E-5 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Pfam PF07494 Two component regulator propeller 304 327 7.9E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 PANTHER PTHR24423 958 1227 8.8E-96 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 PANTHER PTHR24423 760 937 8.8E-96 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF63829 477 576 8.83E-9 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Pfam PF07495 Y_Y_Y domain 676 739 1.2E-12 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SMART SM00448 1072 1185 1.7E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF63829 8 180 1.19E-8 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 911 1026 8.4E-13 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Pfam PF12833 Helix-turn-helix domain 1245 1319 8.1E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SMART SM00388 794 860 4.1E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Pfam PF00072 Response regulator receiver domain 1074 1185 2.8E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 PANTHER PTHR24423:SF487 958 1227 8.8E-96 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 PANTHER PTHR24423:SF487 760 937 8.8E-96 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 1272 1314 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Gene3D G3DSA:3.30.565.10 846 1035 2.5E-28 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SMART SM00387 906 1032 1.4E-19 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Gene3D G3DSA:1.10.287.130 787 845 2.6E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF46689 1271 1320 2.64E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF63829 310 445 8.83E-9 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF55874 850 1030 1.83E-26 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SMART SM00342 1235 1318 3.6E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Gene3D G3DSA:3.40.50.2300 1067 1199 1.4E-34 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF47384 786 861 1.14E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Gene3D G3DSA:1.10.10.60 1271 1320 9.4E-18 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF63829 138 338 2.83E-12 T 21-04-2016 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Pfam PF00512 His Kinase A (phospho-acceptor) domain 796 859 1.8E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 SUPERFAMILY SSF52172 1073 1199 1.39E-28 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Gene3D G3DSA:2.120.10.30 180 282 1.4E-7 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS09300 a2b7354af060a33e0ee8577a31b452ee 1323 Gene3D G3DSA:2.120.10.30 303 432 2.1E-4 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 PANTHER PTHR11552:SF139 7 89 3.3E-48 T 21-04-2016 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 PANTHER PTHR11552:SF139 105 558 3.3E-48 T 21-04-2016 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 SUPERFAMILY SSF51905 494 555 3.37E-64 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 SUPERFAMILY SSF51905 2 337 3.37E-64 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 Pfam PF05199 GMC oxidoreductase 423 546 7.5E-22 T 21-04-2016 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 PANTHER PTHR11552 7 89 3.3E-48 T 21-04-2016 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 PANTHER PTHR11552 105 558 3.3E-48 T 21-04-2016 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 Gene3D G3DSA:3.50.50.60 226 334 5.0E-73 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 Gene3D G3DSA:3.50.50.60 433 446 5.0E-73 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 Gene3D G3DSA:3.50.50.60 485 553 5.0E-73 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 Gene3D G3DSA:3.50.50.60 3 156 5.0E-73 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 Pfam PF00732 GMC oxidoreductase 67 311 2.3E-15 T 21-04-2016 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 SPH21_RS18140 57d21a9c74e2be684728458c5c524530 559 SUPERFAMILY SSF54373 348 495 3.02E-51 T 21-04-2016 SPH21_RS05905 2851d99ba31413d04e9ff46fafee7cf1 348 PANTHER PTHR36927 1 347 3.9E-27 T 21-04-2016 SPH21_RS05905 2851d99ba31413d04e9ff46fafee7cf1 348 Pfam PF01757 Acyltransferase family 7 331 2.2E-25 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS08830 67dd6d5d8359f6c40da737193a048175 334 SUPERFAMILY SSF53756 5 330 1.47E-22 T 21-04-2016 SPH21_RS08830 67dd6d5d8359f6c40da737193a048175 334 Pfam PF13692 Glycosyl transferases group 1 178 302 3.4E-9 T 21-04-2016 SPH21_RS07860 d2225444fb3f409746a53ff902f8a541 183 Gene3D G3DSA:3.40.50.700 31 157 1.3E-33 T 21-04-2016 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 SPH21_RS07860 d2225444fb3f409746a53ff902f8a541 183 TIGRFAM TIGR01957 nuoB_fam: NADH-quinone oxidoreductase, B subunit 18 159 3.1E-62 T 21-04-2016 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 SPH21_RS07860 d2225444fb3f409746a53ff902f8a541 183 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 44 152 3.4E-24 T 21-04-2016 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 SPH21_RS07860 d2225444fb3f409746a53ff902f8a541 183 SUPERFAMILY SSF56770 16 164 4.19E-62 T 21-04-2016 SPH21_RS07860 d2225444fb3f409746a53ff902f8a541 183 PANTHER PTHR11995:SF2 17 166 2.6E-75 T 21-04-2016 SPH21_RS07860 d2225444fb3f409746a53ff902f8a541 183 PANTHER PTHR11995 17 166 2.6E-75 T 21-04-2016 SPH21_RS07860 d2225444fb3f409746a53ff902f8a541 183 Hamap MF_01356 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic [ndhK]. 11 158 40.511 T 21-04-2016 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 Gene3D G3DSA:3.40.50.720 2 225 4.4E-67 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 Pfam PF00106 short chain dehydrogenase 8 195 7.5E-57 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PANTHER PTHR24322 12 140 6.4E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PANTHER PTHR24322 156 192 6.4E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 8.8E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 202 222 8.8E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 8.8E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 8.8E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 8.8E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 8.8E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 SUPERFAMILY SSF51735 2 236 6.89E-68 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 7.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 7.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18830 f0359c3fec92fb0fb79414f2aaaa0c71 242 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 7.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22635 f253477f745e38b18d573b83188a637c 406 PANTHER PTHR23505 6 376 2.2E-64 T 21-04-2016 SPH21_RS22635 f253477f745e38b18d573b83188a637c 406 Gene3D G3DSA:1.20.1250.20 211 402 5.2E-20 T 21-04-2016 SPH21_RS22635 f253477f745e38b18d573b83188a637c 406 Pfam PF07690 Major Facilitator Superfamily 16 365 8.6E-56 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS22635 f253477f745e38b18d573b83188a637c 406 Gene3D G3DSA:1.20.1250.20 7 195 3.0E-39 T 21-04-2016 SPH21_RS22635 f253477f745e38b18d573b83188a637c 406 SUPERFAMILY SSF103473 4 402 9.16E-73 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 PANTHER PTHR11735:SF11 1 134 2.0E-42 T 21-04-2016 SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 Gene3D G3DSA:3.30.420.40 130 185 1.1E-5 T 21-04-2016 SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 PANTHER PTHR11735 1 134 2.0E-42 T 21-04-2016 SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 Pfam PF00814 Glycoprotease family 35 216 4.2E-27 T 21-04-2016 IPR000905 Gcp-like domain KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 Gene3D G3DSA:3.30.420.40 1 129 2.6E-38 T 21-04-2016 SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 SUPERFAMILY SSF53067 1 100 3.5E-27 T 21-04-2016 SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 SUPERFAMILY SSF53067 118 220 4.73E-11 T 21-04-2016 SPH21_RS01590 ef1e20c3a89d90d28ab8976fa89f7d43 235 TIGRFAM TIGR03725 T6A_YeaZ: tRNA threonylcarbamoyl adenosine modification protein YeaZ 3 222 5.4E-49 T 21-04-2016 IPR022496 tRNA threonylcarbamoyl adenosine modification protein YeaZ GO:0002949 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 Gene3D G3DSA:3.30.420.140 1 135 5.4E-43 T 21-04-2016 IPR006641 YqgF/RNase H-like domain GO:0006139 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 Pfam PF03652 Holliday junction resolvase 1 133 2.5E-41 T 21-04-2016 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 SMART SM00732 1 99 5.4E-25 T 21-04-2016 IPR006641 YqgF/RNase H-like domain GO:0006139 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 PANTHER PTHR33317:SF1 1 132 5.5E-35 T 21-04-2016 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 SUPERFAMILY SSF53098 1 135 5.92E-37 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 PANTHER PTHR33317 1 132 5.5E-35 T 21-04-2016 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 TIGRFAM TIGR00250 RNAse_H_YqgF: putative transcription antitermination factor YqgF 4 132 7.9E-27 T 21-04-2016 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 SPH21_RS03770 40054cdd2529f780a84024d8ed16d46e 137 Hamap MF_00651 Putative pre-16S rRNA nuclease [yqgF]. 1 136 23.338 T 21-04-2016 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 SPH21_RS25005 91ec09c8e3ec3fb3f8f05da2ce17b9c9 183 SUPERFAMILY SSF47240 21 172 5.65E-45 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS25005 91ec09c8e3ec3fb3f8f05da2ce17b9c9 183 PANTHER PTHR30565:SF2 23 183 2.5E-43 T 21-04-2016 SPH21_RS25005 91ec09c8e3ec3fb3f8f05da2ce17b9c9 183 Gene3D G3DSA:1.20.1260.10 19 181 2.4E-59 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS25005 91ec09c8e3ec3fb3f8f05da2ce17b9c9 183 Pfam PF05974 Domain of unknown function (DUF892) 23 179 1.2E-53 T 21-04-2016 IPR010287 Domain of unknown function DUF892 SPH21_RS25005 91ec09c8e3ec3fb3f8f05da2ce17b9c9 183 PANTHER PTHR30565 23 183 2.5E-43 T 21-04-2016 SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 PANTHER PTHR11851:SF140 20 425 3.7E-40 T 21-04-2016 SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 Gene3D G3DSA:3.30.830.10 245 426 1.4E-26 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 Gene3D G3DSA:3.30.830.10 26 222 1.6E-20 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 Pfam PF00675 Insulinase (Peptidase family M16) 69 152 2.1E-5 T 21-04-2016 IPR011765 Peptidase M16, N-terminal SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 Pfam PF05193 Peptidase M16 inactive domain 182 358 5.2E-20 T 21-04-2016 IPR007863 Peptidase M16, C-terminal SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 PANTHER PTHR11851 20 425 3.7E-40 T 21-04-2016 SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 SUPERFAMILY SSF63411 19 226 3.19E-26 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS18305 b8d243b3bbea99c4588aed0e05fcbc33 429 SUPERFAMILY SSF63411 246 426 9.73E-36 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 SMART SM00997 197 358 2.0E-110 T 21-04-2016 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 SUPERFAMILY SSF52283 8 196 9.07E-120 T 21-04-2016 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 SUPERFAMILY SSF52283 359 438 9.07E-120 T 21-04-2016 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 TIGRFAM TIGR00936 ahcY: adenosylhomocysteinase 11 430 1.0E-193 T 21-04-2016 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 SUPERFAMILY SSF51735 197 358 4.8E-73 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 Pfam PF05221 S-adenosyl-L-homocysteine hydrolase 147 437 9.7E-64 T 21-04-2016 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 Pfam PF05221 S-adenosyl-L-homocysteine hydrolase 11 146 2.9E-70 T 21-04-2016 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 ProSitePatterns PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. 82 96 - T 21-04-2016 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 SMART SM00996 10 437 0.0 T 21-04-2016 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 Pfam PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 197 358 1.3E-79 T 21-04-2016 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 ProSitePatterns PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. 219 235 - T 21-04-2016 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 Gene3D G3DSA:3.40.50.1480 359 438 3.1E-141 T 21-04-2016 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 Gene3D G3DSA:3.40.50.1480 11 198 3.1E-141 T 21-04-2016 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 PIRSF PIRSF001109 1 438 5.8E-196 T 21-04-2016 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 Gene3D G3DSA:3.40.50.720 199 357 1.2E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 PANTHER PTHR23420 10 438 0.0 T 21-04-2016 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS06085 dcb16a2ec6c881ea01578d13ee219858 438 Hamap MF_00563 Adenosylhomocysteinase [ahcY]. 6 430 47.953 T 21-04-2016 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041|UniPathway: UPA00314 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 Gene3D G3DSA:3.30.360.10 245 420 2.4E-12 T 21-04-2016 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 Gene3D G3DSA:3.30.360.10 194 212 2.4E-12 T 21-04-2016 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 PANTHER PTHR22604 9 205 1.9E-114 T 21-04-2016 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 PANTHER PTHR22604 223 451 1.9E-114 T 21-04-2016 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 PANTHER PTHR22604:SF101 9 205 1.9E-114 T 21-04-2016 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 PANTHER PTHR22604:SF101 223 451 1.9E-114 T 21-04-2016 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 51 170 4.7E-18 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 SUPERFAMILY SSF55347 180 407 3.92E-20 T 21-04-2016 SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 SUPERFAMILY SSF51735 40 202 1.79E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18135 8ea6c54a95b2a0159caa9b625a62145a 485 Gene3D G3DSA:3.40.50.720 44 193 1.8E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20145 cd672a1e13768d94f522e21fb152ade7 375 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 45 369 1.9E-58 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS20145 cd672a1e13768d94f522e21fb152ade7 375 PANTHER PTHR30469:SF4 12 327 2.0E-54 T 21-04-2016 SPH21_RS20145 cd672a1e13768d94f522e21fb152ade7 375 PANTHER PTHR30469 12 327 2.0E-54 T 21-04-2016 SPH21_RS20145 cd672a1e13768d94f522e21fb152ade7 375 SUPERFAMILY SSF111369 58 294 9.15E-24 T 21-04-2016 SPH21_RS20145 cd672a1e13768d94f522e21fb152ade7 375 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 56 288 1.3E-25 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS20145 cd672a1e13768d94f522e21fb152ade7 375 Gene3D G3DSA:2.40.50.100 68 102 2.0E-14 T 21-04-2016 SPH21_RS20145 cd672a1e13768d94f522e21fb152ade7 375 Gene3D G3DSA:2.40.50.100 178 203 2.0E-14 T 21-04-2016 SPH21_RS04330 fcae14a0f257e58d23f669845ee572a5 297 Gene3D G3DSA:1.10.10.60 250 296 3.1E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04330 fcae14a0f257e58d23f669845ee572a5 297 SUPERFAMILY SSF46689 250 296 2.46E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04330 fcae14a0f257e58d23f669845ee572a5 297 PANTHER PTHR11019:SF45 53 296 7.3E-15 T 21-04-2016 SPH21_RS04330 fcae14a0f257e58d23f669845ee572a5 297 PANTHER PTHR11019 53 296 7.3E-15 T 21-04-2016 SPH21_RS04330 fcae14a0f257e58d23f669845ee572a5 297 SMART SM00342 212 295 3.4E-11 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04330 fcae14a0f257e58d23f669845ee572a5 297 Pfam PF12833 Helix-turn-helix domain 219 296 5.2E-13 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 SMART SM00490 256 337 8.1E-33 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 PANTHER PTHR24031 2 370 9.1E-182 T 21-04-2016 SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 Pfam PF00271 Helicase conserved C-terminal domain 229 337 8.3E-31 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 SUPERFAMILY SSF52540 73 356 6.44E-75 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 SMART SM00487 20 220 3.5E-61 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 Gene3D G3DSA:3.40.50.300 211 368 1.3E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 PANTHER PTHR24031:SF261 2 370 9.1E-182 T 21-04-2016 SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 Gene3D G3DSA:3.40.50.300 2 210 2.9E-81 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 ProSitePatterns PS00039 DEAD-box subfamily ATP-dependent helicases signature. 151 159 - T 21-04-2016 IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site SPH21_RS03815 cab08424226dfd57c8f85b7668ea6762 419 Pfam PF00270 DEAD/DEAH box helicase 25 194 1.9E-48 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 SUPERFAMILY SSF46785 13 109 1.03E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 Pfam PF12840 Helix-turn-helix domain 19 76 2.0E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 PANTHER PTHR33154:SF6 18 109 6.4E-21 T 21-04-2016 SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 SMART SM00418 19 100 1.5E-11 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 PANTHER PTHR33154 18 109 6.4E-21 T 21-04-2016 SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 21 36 3.4E-7 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 68 83 3.4E-7 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 53 68 3.4E-7 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS22700 709ca19a2c343b26d6b9e14d382c05d1 120 Gene3D G3DSA:1.10.10.10 15 118 8.7E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17865 3771b6d30abbbd2cf3038ccf279d725f 106 Pfam PF00581 Rhodanese-like domain 15 91 2.7E-13 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17865 3771b6d30abbbd2cf3038ccf279d725f 106 Gene3D G3DSA:3.40.250.10 13 92 9.2E-24 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17865 3771b6d30abbbd2cf3038ccf279d725f 106 SUPERFAMILY SSF52821 7 92 5.76E-23 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17865 3771b6d30abbbd2cf3038ccf279d725f 106 SMART SM00450 12 104 1.9E-16 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 Gene3D G3DSA:3.40.50.1000 512 652 5.8E-52 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 Gene3D G3DSA:3.40.50.1000 363 405 5.8E-52 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 Pfam PF00122 E1-E2 ATPase 160 380 6.6E-58 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 Gene3D G3DSA:3.40.1110.10 411 511 2.0E-14 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 391 397 - T 21-04-2016 IPR018303 P-type ATPase, phosphorylation site SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PANTHER PTHR24093 5 693 3.0E-267 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 161 663 6.5E-83 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PANTHER PTHR24093:SF332 5 693 3.0E-267 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 SUPERFAMILY SSF81653 191 288 9.29E-23 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 607 619 1.4E-26 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 509 520 1.4E-26 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 238 252 1.4E-26 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 389 403 1.4E-26 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 584 603 1.4E-26 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 531 541 1.4E-26 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 SUPERFAMILY SSF56784 387 407 5.04E-54 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 SUPERFAMILY SSF56784 447 689 5.04E-54 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 Pfam PF00702 haloacid dehalogenase-like hydrolase 385 598 3.9E-40 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 SUPERFAMILY SSF81665 633 671 1.06E-11 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 SUPERFAMILY SSF81665 158 192 1.06E-11 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 SUPERFAMILY SSF81665 289 383 1.06E-11 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 109 693 2.5E-175 T 21-04-2016 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 Gene3D G3DSA:2.70.150.10 154 289 6.6E-25 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 615 640 2.8E-10 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 556 572 2.8E-10 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 584 600 2.8E-10 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS01380 e1974df9ef4b3d655ae2449a24ee56fe 696 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 127 691 7.4E-172 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 231 250 4.2E-9 T 21-04-2016 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 146 160 4.2E-9 T 21-04-2016 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 298 313 4.2E-9 T 21-04-2016 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 PANTHER PTHR22573 29 576 1.4E-213 T 21-04-2016 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 SUPERFAMILY SSF53738 306 454 2.86E-29 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 SUPERFAMILY SSF53738 209 317 7.85E-22 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 SUPERFAMILY SSF53738 38 237 3.57E-46 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Gene3D G3DSA:3.30.310.50 480 574 1.9E-18 T 21-04-2016 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 51 186 8.2E-40 T 21-04-2016 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Gene3D G3DSA:3.40.120.10 232 310 6.3E-21 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 211 314 3.3E-23 T 21-04-2016 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 510 550 1.8E-7 T 21-04-2016 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 PANTHER PTHR22573:SF54 29 576 1.4E-213 T 21-04-2016 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Gene3D G3DSA:3.40.120.10 23 217 3.4E-61 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Gene3D G3DSA:3.40.120.10 311 454 9.4E-34 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 SUPERFAMILY SSF55957 468 552 3.4E-12 T 21-04-2016 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 326 444 1.8E-20 T 21-04-2016 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS09965 f246b918c93ee740b894a3e3cd470475 579 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 147 156 - T 21-04-2016 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 SMART SM00850 137 228 7.9E-22 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 Pfam PF00072 Response regulator receiver domain 4 110 1.9E-11 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 Gene3D G3DSA:2.40.50.40 129 196 1.6E-20 T 21-04-2016 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 SMART SM00448 1 110 3.0E-8 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 PANTHER PTHR37299 76 202 3.0E-13 T 21-04-2016 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 PANTHER PTHR37299:SF1 76 202 3.0E-13 T 21-04-2016 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 Gene3D G3DSA:3.40.50.2300 1 113 3.2E-15 T 21-04-2016 SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 SUPERFAMILY SSF52172 1 113 4.84E-16 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS24090 8394556ccd4605738b78ebdf0b934347 230 Pfam PF04397 LytTr DNA-binding domain 141 221 5.1E-18 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS17050 bfb1554612ca0a113a7f102c27841467 343 Gene3D G3DSA:3.20.20.100 12 329 1.3E-84 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS17050 bfb1554612ca0a113a7f102c27841467 343 SUPERFAMILY SSF51430 13 329 9.95E-88 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS17050 bfb1554612ca0a113a7f102c27841467 343 Pfam PF00248 Aldo/keto reductase family 28 327 2.1E-66 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS17050 bfb1554612ca0a113a7f102c27841467 343 PANTHER PTHR11732:SF191 13 329 2.3E-174 T 21-04-2016 SPH21_RS17050 bfb1554612ca0a113a7f102c27841467 343 PANTHER PTHR11732 13 329 2.3E-174 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 PANTHER PTHR30269:SF5 252 498 2.0E-52 T 21-04-2016 SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 SUPERFAMILY SSF51735 24 136 9.06E-16 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 Gene3D G3DSA:3.30.160.110 138 172 4.0E-12 T 21-04-2016 SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 Gene3D G3DSA:3.40.50.720 23 136 2.1E-29 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 Pfam PF14824 Sirohaem biosynthesis protein central 144 169 1.0E-9 T 21-04-2016 IPR028281 Siroheme synthase, central domain KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 SUPERFAMILY SSF75615 132 209 4.97E-16 T 21-04-2016 SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 Pfam PF01925 Sulfite exporter TauE/SafE 261 495 9.8E-33 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 PANTHER PTHR30269 252 498 2.0E-52 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 Pfam PF13241 Putative NAD(P)-binding 27 139 4.0E-25 T 21-04-2016 IPR006367 Sirohaem synthase, N-terminal GO:0006779|GO:0019354|GO:0043115|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS15900 eb36d94cbf491c0640570cb049216eb8 507 TIGRFAM TIGR01470 cysG_Nterm: siroheme synthase, N-terminal domain 25 198 4.9E-37 T 21-04-2016 IPR006367 Sirohaem synthase, N-terminal GO:0006779|GO:0019354|GO:0043115|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 SMART SM00465 16 99 6.0E-20 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 Pfam PF01541 GIY-YIG catalytic domain 17 94 2.0E-10 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 SUPERFAMILY SSF46600 197 246 7.59E-5 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 PANTHER PTHR30562 6 597 5.9E-211 T 21-04-2016 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 Gene3D G3DSA:3.40.1440.10 16 96 6.1E-12 T 21-04-2016 IPR027299 GIY-YIG domain SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 Gene3D G3DSA:4.10.860.10 189 244 1.2E-6 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 SUPERFAMILY SSF82771 15 101 2.35E-22 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 Pfam PF08459 UvrC Helix-hairpin-helix N-terminal 383 533 5.5E-47 T 21-04-2016 IPR001162 UvrC family homology region SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 Gene3D G3DSA:1.10.150.20 548 598 5.6E-15 T 21-04-2016 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 Hamap MF_00203 UvrABC system protein C [uvrC]. 3 598 25.827 T 21-04-2016 IPR004791 UvrABC system, subunit C GO:0005737|GO:0006281|GO:0009380|GO:0009381 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 PANTHER PTHR30562:SF1 6 597 5.9E-211 T 21-04-2016 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 TIGRFAM TIGR00194 uvrC: excinuclease ABC subunit C 8 580 6.6E-157 T 21-04-2016 IPR004791 UvrABC system, subunit C GO:0005737|GO:0006281|GO:0009380|GO:0009381 SPH21_RS25800 d8a701404ce66f6426623aba683e59d0 599 SUPERFAMILY SSF47781 492 598 1.08E-18 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 Pfam PF01709 Transcriptional regulator 5 240 2.0E-75 T 21-04-2016 IPR002876 Transcriptional regulator TACO1-like SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 PANTHER PTHR12532 1 240 2.1E-78 T 21-04-2016 IPR002876 Transcriptional regulator TACO1-like SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 SUPERFAMILY SSF75625 1 240 7.85E-74 T 21-04-2016 IPR029072 YebC-like SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 Hamap MF_00693 Probable transcriptional regulatory protein YebC [yebC]. 1 241 27.719 T 21-04-2016 IPR002876 Transcriptional regulator TACO1-like SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 Gene3D G3DSA:3.30.70.980 134 205 1.6E-23 T 21-04-2016 IPR026564 Transcriptional regulator TACO1-like, domain 3 SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 TIGRFAM TIGR01033 TIGR01033: DNA-binding regulatory protein, YebC/PmpR family 2 240 8.0E-77 T 21-04-2016 IPR002876 Transcriptional regulator TACO1-like SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 Gene3D G3DSA:1.10.10.200 1 77 1.9E-25 T 21-04-2016 IPR017856 Integrase, N-terminal zinc-binding domain-like SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 Gene3D G3DSA:3.30.1270.10 79 133 7.9E-34 T 21-04-2016 IPR026563 Transcriptional regulator TACO1-like, domain 2 SPH21_RS05305 d37303308f5ddca6e84eb85d02d108b3 241 Gene3D G3DSA:3.30.1270.10 215 240 7.9E-34 T 21-04-2016 IPR026563 Transcriptional regulator TACO1-like, domain 2 SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 Pfam PF04542 Sigma-70 region 2 13 77 1.1E-12 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 SUPERFAMILY SSF88659 105 173 3.36E-11 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 Pfam PF08281 Sigma-70, region 4 123 158 2.1E-7 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 PANTHER PTHR30173 16 173 3.1E-26 T 21-04-2016 SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 Gene3D G3DSA:1.10.10.10 112 173 7.1E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 SUPERFAMILY SSF88946 13 88 1.73E-14 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 13 173 5.0E-22 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20030 209ec60a517a2b738ee11d89098c48f7 182 Gene3D G3DSA:1.10.1740.10 6 77 8.6E-15 T 21-04-2016 SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 Gene3D G3DSA:2.40.100.10 167 215 2.2E-42 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 Gene3D G3DSA:2.40.100.10 20 133 2.2E-42 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 PANTHER PTHR11071:SF192 37 134 7.1E-27 T 21-04-2016 SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 PANTHER PTHR11071:SF192 168 212 7.1E-27 T 21-04-2016 SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 SUPERFAMILY SSF50891 24 133 1.29E-37 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 SUPERFAMILY SSF50891 167 211 1.29E-37 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 PANTHER PTHR11071 37 134 7.1E-27 T 21-04-2016 IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase GO:0003755|GO:0006457 SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 PANTHER PTHR11071 168 212 7.1E-27 T 21-04-2016 IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase GO:0003755|GO:0006457 SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 ProSitePatterns PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 60 77 - T 21-04-2016 IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site GO:0003755|GO:0006457 SPH21_RS06850 806ec70d672edcb6ad207056754e2678 247 Pfam PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 36 211 1.5E-39 T 21-04-2016 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 TIGRFAM TIGR00536 hemK_fam: methyltransferase, HemK family 24 282 2.2E-56 T 21-04-2016 IPR004556 Modification methylase HemK GO:0006479|GO:0008276 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 Gene3D G3DSA:1.10.8.10 5 87 1.2E-16 T 21-04-2016 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 Pfam PF05175 Methyltransferase small domain 107 201 5.7E-16 T 21-04-2016 IPR007848 Methyltransferase small domain GO:0008168 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 PANTHER PTHR18895:SF64 11 284 2.3E-71 T 21-04-2016 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 TIGRFAM TIGR03534 RF_mod_PrmC: protein-(glutamine-N5) methyltransferase, release factor-specific 29 282 2.5E-77 T 21-04-2016 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 189 195 - T 21-04-2016 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 SUPERFAMILY SSF53335 24 271 5.28E-52 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 PANTHER PTHR18895 11 284 2.3E-71 T 21-04-2016 SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 Gene3D G3DSA:3.40.50.150 89 284 3.5E-58 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS16880 59bc44b60f4f50f8144321e0ec83f0b0 286 Hamap MF_02126 Release factor glutamine methyltransferase [prmC]. 6 286 36.684 T 21-04-2016 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 Pfam PF01965 DJ-1/PfpI family 566 674 6.7E-12 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 Pfam PF00199 Catalase 34 419 9.1E-181 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PANTHER PTHR11465:SF7 13 526 0.0 T 21-04-2016 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PANTHER PTHR11465:SF7 547 599 0.0 T 21-04-2016 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 SMART SM01060 34 422 3.5E-278 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 SUPERFAMILY SSF52317 565 676 3.66E-18 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PRINTS PR00067 Catalase signature 131 148 2.4E-66 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PRINTS PR00067 Catalase signature 351 377 2.4E-66 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PRINTS PR00067 Catalase signature 319 346 2.4E-66 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PRINTS PR00067 Catalase signature 150 168 2.4E-66 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PRINTS PR00067 Catalase signature 47 70 2.4E-66 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PRINTS PR00067 Catalase signature 110 128 2.4E-66 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 Gene3D G3DSA:2.40.180.10 12 388 1.2E-180 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PIRSF PIRSF038927 1 726 0.0 T 21-04-2016 IPR024712 Catalase, mono-functional, haem-containing, clade 2 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 SUPERFAMILY SSF56634 21 527 3.66E-217 T 21-04-2016 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 Pfam PF06628 Catalase-related immune-responsive 450 513 3.0E-20 T 21-04-2016 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 Gene3D G3DSA:3.40.50.880 565 728 9.7E-49 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 ProSitePatterns PS00438 Catalase proximal active site signature. 70 86 - T 21-04-2016 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 ProSitePatterns PS00437 Catalase proximal heme-ligand signature. 364 372 - T 21-04-2016 IPR002226 Catalase haem-binding site GO:0020037 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PANTHER PTHR11465 13 526 0.0 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25000 5e4f11033cac0d2d105e5b3dd9ec0145 728 PANTHER PTHR11465 547 599 0.0 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS25115 0c3792c4906d8a03adcf5920e1e84d71 155 Gene3D G3DSA:1.10.10.10 6 147 2.8E-31 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS25115 0c3792c4906d8a03adcf5920e1e84d71 155 SUPERFAMILY SSF46785 22 149 1.59E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS25115 0c3792c4906d8a03adcf5920e1e84d71 155 PANTHER PTHR33164:SF12 16 155 6.3E-26 T 21-04-2016 SPH21_RS25115 0c3792c4906d8a03adcf5920e1e84d71 155 Pfam PF12802 MarR family 36 93 2.0E-12 T 21-04-2016 SPH21_RS25115 0c3792c4906d8a03adcf5920e1e84d71 155 SMART SM00347 30 131 6.7E-14 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS25115 0c3792c4906d8a03adcf5920e1e84d71 155 PANTHER PTHR33164 16 155 6.3E-26 T 21-04-2016 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 SUPERFAMILY SSF51556 3 253 1.21E-79 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 PANTHER PTHR10060:SF21 3 254 1.0E-100 T 21-04-2016 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 Pfam PF01026 TatD related DNase 4 252 6.9E-68 T 21-04-2016 IPR001130 TatD family GO:0016788 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 TIGRFAM TIGR00010 TIGR00010: hydrolase, TatD family 3 253 1.5E-74 T 21-04-2016 IPR015991 Uncharacterised deoxyribonuclease TatD-type GO:0004536 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 PIRSF PIRSF005902 1 254 5.3E-75 T 21-04-2016 IPR001130 TatD family GO:0016788 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 Gene3D G3DSA:3.20.20.140 1 253 4.7E-82 T 21-04-2016 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 PANTHER PTHR10060 3 254 1.0E-100 T 21-04-2016 IPR001130 TatD family GO:0016788 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 ProSitePatterns PS01091 TatD deoxyribonuclease family signature 3. 189 205 - T 21-04-2016 IPR018228 Deoxyribonuclease, TatD-related, conserved site GO:0016888 SPH21_RS06115 b4249d9c30420d859477a28c688530fc 254 ProSitePatterns PS01090 TatD deoxyribonuclease family signature 2. 125 135 - T 21-04-2016 IPR018228 Deoxyribonuclease, TatD-related, conserved site GO:0016888 SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 SUPERFAMILY SSF51735 10 256 8.98E-70 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PANTHER PTHR24322 152 183 5.3E-42 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PANTHER PTHR24322 15 135 5.3E-42 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 131 139 1.1E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 76 87 1.1E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 1.1E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 Gene3D G3DSA:3.40.50.720 2 256 4.7E-72 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 255 6.0E-47 T 21-04-2016 SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 2.1E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 220 240 2.1E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 2.1E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 2.1E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 2.1E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21635 d9e8f0e0811e28b0ef29a85045490891 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 2.1E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 Hamap MF_00367 GTPase Era [era]. 3 290 34.026 T 21-04-2016 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 PANTHER PTHR11649:SF3 3 292 4.0E-108 T 21-04-2016 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 6 164 1.9E-28 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 SUPERFAMILY SSF54814 177 291 6.54E-41 T 21-04-2016 IPR009019 K homology domain, prokaryotic type GO:0003723 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 Pfam PF07650 KH domain 203 279 1.7E-18 T 21-04-2016 IPR004044 K Homology domain, type 2 GO:0003723 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 TIGRFAM TIGR00436 era: GTP-binding protein Era 6 273 8.0E-83 T 21-04-2016 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 Gene3D G3DSA:3.40.50.300 6 186 6.0E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 PANTHER PTHR11649 3 292 4.0E-108 T 21-04-2016 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 8 28 1.3E-6 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 57 72 1.3E-6 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 SUPERFAMILY SSF52540 8 201 2.13E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 Gene3D G3DSA:3.30.300.20 187 286 7.8E-39 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS01785 02b75a3fbf433be39184610c06c7c9c5 292 Pfam PF01926 50S ribosome-binding GTPase 8 120 3.0E-24 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS22895 c9af232820dc5fd9d2a9fc6c361905db 364 Gene3D G3DSA:2.120.10.20 44 360 2.9E-91 T 21-04-2016 IPR003431 Beta propeller phytase GO:0016158 KEGG: 00562+3.1.3.8|MetaCyc: PWY-4702 SPH21_RS22895 c9af232820dc5fd9d2a9fc6c361905db 364 Pfam PF02333 Phytase 50 344 3.3E-43 T 21-04-2016 IPR003431 Beta propeller phytase GO:0016158 KEGG: 00562+3.1.3.8|MetaCyc: PWY-4702 SPH21_RS22895 c9af232820dc5fd9d2a9fc6c361905db 364 SUPERFAMILY SSF50956 45 354 8.63E-64 T 21-04-2016 SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 ProSitePatterns PS00149 Sulfatases signature 2. 127 138 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 PANTHER PTHR10342:SF207 269 491 4.3E-163 T 21-04-2016 SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 PANTHER PTHR10342:SF207 7 249 4.3E-163 T 21-04-2016 SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 Pfam PF00884 Sulfatase 38 377 3.1E-63 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 SUPERFAMILY SSF53649 35 484 1.74E-116 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 PANTHER PTHR10342 269 491 4.3E-163 T 21-04-2016 SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 PANTHER PTHR10342 7 249 4.3E-163 T 21-04-2016 SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 ProSitePatterns PS00523 Sulfatases signature 1. 82 94 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS25465 6de5ffb17c0773726b9feb0e13afceb6 492 Gene3D G3DSA:3.40.720.10 34 396 6.5E-105 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 Pfam PF00994 Probable molybdopterin binding domain 150 292 1.9E-29 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 SUPERFAMILY SSF55040 1 138 1.44E-40 T 21-04-2016 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 UniPathway: UPA00344 SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 Pfam PF01967 MoaC family 1 135 3.3E-40 T 21-04-2016 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 UniPathway: UPA00344 SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 148 286 1.8E-28 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 Gene3D G3DSA:3.30.70.640 1 138 7.1E-43 T 21-04-2016 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 UniPathway: UPA00344 SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 PIRSF PIRSF036594 1 303 5.0E-76 T 21-04-2016 IPR012247 Bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA GO:0006777 UniPathway: UPA00344 SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 SMART SM00852 150 293 3.2E-23 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 SUPERFAMILY SSF53218 147 296 5.37E-41 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 Gene3D G3DSA:3.40.980.10 146 298 3.1E-46 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18590 0a19adb2e6ea5d9b3ddf32280214dd6f 303 PANTHER PTHR10192 140 292 3.1E-52 T 21-04-2016 SPH21_RS13325 e2900c6a582cbed0986b155bae39c5fb 234 Gene3D G3DSA:3.90.550.10 5 232 1.3E-26 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS13325 e2900c6a582cbed0986b155bae39c5fb 234 SUPERFAMILY SSF53448 5 232 1.53E-30 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS13325 e2900c6a582cbed0986b155bae39c5fb 234 Pfam PF12804 MobA-like NTP transferase domain 4 157 1.3E-13 T 21-04-2016 IPR025877 MobA-like NTP transferase SPH21_RS16940 53bd2e99a7db0d178e065afd70b85d2c 532 Gene3D G3DSA:2.60.40.1120 109 171 7.2E-8 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS16940 53bd2e99a7db0d178e065afd70b85d2c 532 Pfam PF13715 CarboxypepD_reg-like domain 110 169 2.5E-8 T 21-04-2016 SPH21_RS16940 53bd2e99a7db0d178e065afd70b85d2c 532 SUPERFAMILY SSF49464 108 172 3.14E-8 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 Pfam PF01416 tRNA pseudouridine synthase 149 251 7.1E-19 T 21-04-2016 IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 Gene3D G3DSA:3.30.70.660 114 248 1.9E-35 T 21-04-2016 IPR020095 Pseudouridine synthase I, TruA, C-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 Gene3D G3DSA:3.30.70.580 5 112 2.7E-30 T 21-04-2016 IPR020094 Pseudouridine synthase I, TruA, N-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 PIRSF PIRSF001430 5 255 4.4E-67 T 21-04-2016 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 SUPERFAMILY SSF55120 6 251 1.73E-68 T 21-04-2016 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 Hamap MF_00171 tRNA pseudouridine synthase A [truA]. 6 250 29.528 T 21-04-2016 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 TIGRFAM TIGR00071 hisT_truA: tRNA pseudouridine(38-40) synthase 10 245 1.4E-44 T 21-04-2016 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 PANTHER PTHR11142:SF0 7 251 3.0E-62 T 21-04-2016 SPH21_RS11955 9c0f57141bc621ab079271cbf9a5c353 255 PANTHER PTHR11142 7 251 3.0E-62 T 21-04-2016 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS03890 77672caa7f3a07e9d2a0f9e30c10100e 304 SUPERFAMILY SSF75005 55 294 1.45E-36 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS03890 77672caa7f3a07e9d2a0f9e30c10100e 304 Gene3D G3DSA:2.115.10.20 60 255 3.9E-28 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS03890 77672caa7f3a07e9d2a0f9e30c10100e 304 Pfam PF04616 Glycosyl hydrolases family 43 63 260 4.3E-11 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 PANTHER PTHR10196 1 504 2.6E-261 T 21-04-2016 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 362 382 - T 21-04-2016 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 SUPERFAMILY SSF53067 5 255 1.54E-98 T 21-04-2016 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 SUPERFAMILY SSF53067 255 495 2.27E-85 T 21-04-2016 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 262 450 2.3E-62 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 Gene3D G3DSA:3.30.420.40 255 496 2.5E-102 T 21-04-2016 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 ProSitePatterns PS00933 FGGY family of carbohydrate kinases signature 1. 136 148 - T 21-04-2016 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 6 252 7.0E-88 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 PANTHER PTHR10196:SF69 1 504 2.6E-261 T 21-04-2016 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 Hamap MF_00186 Glycerol kinase [glpK]. 4 496 58.806 T 21-04-2016 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 PIRSF PIRSF000538 4 501 2.0E-185 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 5 495 9.8E-232 T 21-04-2016 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS14465 f6530cf823b2541393379c616ac00c85 504 Gene3D G3DSA:3.30.420.40 2 253 7.2E-110 T 21-04-2016 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 SUPERFAMILY SSF56801 12 540 3.79E-136 T 21-04-2016 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Gene3D G3DSA:2.30.38.10 323 407 6.2E-22 T 21-04-2016 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Pfam PF07993 Male sterility protein 643 887 9.0E-51 T 21-04-2016 IPR013120 Male sterility, NAD-binding Reactome: REACT_22258 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Gene3D G3DSA:3.40.50.980 16 172 3.3E-47 T 21-04-2016 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Pfam PF00501 AMP-binding enzyme 26 417 1.6E-89 T 21-04-2016 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 41 441 2.0E-120 T 21-04-2016 IPR010071 Amino acid adenylation domain SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 PANTHER PTHR24095 16 890 6.6E-163 T 21-04-2016 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Gene3D G3DSA:3.40.50.720 640 984 9.3E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 SUPERFAMILY SSF51735 640 936 5.19E-28 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 TIGRFAM TIGR01746 Thioester-redct: thioester reductase domain 640 1005 6.7E-79 T 21-04-2016 IPR010080 Thioester reductase-like domain SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Pfam PF00550 Phosphopantetheine attachment site 529 591 2.9E-9 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 SUPERFAMILY SSF47336 522 592 3.14E-14 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Gene3D G3DSA:1.10.1200.10 534 598 8.0E-17 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Gene3D G3DSA:3.40.50.980 173 317 5.1E-34 T 21-04-2016 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 ProSitePatterns PS00455 Putative AMP-binding domain signature. 163 174 - T 21-04-2016 IPR020845 AMP-binding, conserved site SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Gene3D G3DSA:3.30.300.30 412 533 2.6E-30 T 21-04-2016 SPH21_RS23240 e3559e1b18f6e364b0cad51f9359e84d 1009 Pfam PF13193 AMP-binding enzyme C-terminal domain 425 501 1.5E-7 T 21-04-2016 IPR025110 AMP-binding enzyme C-terminal domain SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 PANTHER PTHR31339 192 445 2.4E-110 T 21-04-2016 SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 PANTHER PTHR31339 21 157 2.4E-110 T 21-04-2016 SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 Gene3D G3DSA:2.160.20.10 35 438 2.9E-109 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 ProSitePatterns PS00502 Polygalacturonase active site. 302 316 - T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 Pfam PF00295 Glycosyl hydrolases family 28 204 438 2.6E-26 T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 Pfam PF12708 Pectate lyase superfamily protein 44 96 3.6E-9 T 21-04-2016 IPR024535 Pectate lyase superfamily protein SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 SUPERFAMILY SSF51126 34 435 3.03E-91 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 PANTHER PTHR31339:SF0 192 445 2.4E-110 T 21-04-2016 SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 PANTHER PTHR31339:SF0 21 157 2.4E-110 T 21-04-2016 SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 SMART SM00710 387 409 1500.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 SMART SM00710 295 316 42.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02325 1dd6663314152df140c985f4c0489103 459 SMART SM00710 261 282 2.6 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 Hamap MF_00175 ATP-dependent Clp protease ATP-binding subunit ClpX [clpX]. 2 411 46.302 T 21-04-2016 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 PANTHER PTHR11262:SF4 6 385 3.1E-194 T 21-04-2016 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 TIGRFAM TIGR00382 clpX: ATP-dependent Clp protease, ATP-binding subunit ClpX 6 386 1.3E-173 T 21-04-2016 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 SMART SM00994 7 46 9.8E-17 T 21-04-2016 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 Pfam PF07724 AAA domain (Cdc48 subfamily) 108 305 8.9E-47 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 PANTHER PTHR11262 6 385 3.1E-194 T 21-04-2016 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 Gene3D G3DSA:1.10.8.60 310 405 8.7E-28 T 21-04-2016 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 SUPERFAMILY SSF57716 8 43 2.85E-8 T 21-04-2016 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 SMART SM01086 311 403 7.6E-24 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 112 125 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 311 386 6.4E-13 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 SUPERFAMILY SSF52540 61 390 8.72E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 SMART SM00382 108 269 1.4E-8 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 Pfam PF06689 ClpX C4-type zinc finger 9 45 8.1E-14 T 21-04-2016 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 Gene3D G3DSA:3.40.50.300 63 250 4.3E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14560 d616c34213145c2afaed4ddef487a144 414 Gene3D G3DSA:3.40.50.300 288 306 4.3E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 22 176 8.4E-42 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 Pfam PF04542 Sigma-70 region 2 26 92 8.1E-13 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 Pfam PF08281 Sigma-70, region 4 126 175 1.1E-15 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 PANTHER PTHR30173:SF20 10 176 3.3E-43 T 21-04-2016 SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 PANTHER PTHR30173 10 176 3.3E-43 T 21-04-2016 SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 Gene3D G3DSA:1.10.10.10 119 179 7.2E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 SUPERFAMILY SSF88659 120 186 1.81E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 176 7.7E-27 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 Gene3D G3DSA:1.10.1740.10 11 114 4.6E-24 T 21-04-2016 SPH21_RS09230 7373ee108071d56814390d37f1552b90 194 SUPERFAMILY SSF88946 10 101 9.89E-24 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 Pfam PF00532 Periplasmic binding proteins and sugar binding domain of LacI family 66 323 7.6E-22 T 21-04-2016 IPR001761 Periplasmic binding protein/LacI sugar binding domain SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 Pfam PF00356 Bacterial regulatory proteins, lacI family 8 53 1.0E-11 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 Gene3D G3DSA:3.40.50.2300 59 181 4.6E-38 T 21-04-2016 SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 Gene3D G3DSA:3.40.50.2300 182 316 6.3E-30 T 21-04-2016 SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 SUPERFAMILY SSF47413 6 64 7.31E-13 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 Gene3D G3DSA:1.10.260.40 7 58 2.2E-17 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 SUPERFAMILY SSF53822 66 321 1.92E-53 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 SMART SM00354 6 76 3.2E-20 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS16355 35f89a47afe99a63f5764b1b9abd6408 345 PANTHER PTHR30146 6 341 1.6E-79 T 21-04-2016 SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 SMART SM00450 29 125 2.7E-16 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 Pfam PF00581 Rhodanese-like domain 39 121 8.8E-12 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 SUPERFAMILY SSF52821 7 128 1.19E-21 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 Gene3D G3DSA:3.40.30.10 127 232 6.3E-21 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 Pfam PF00085 Thioredoxin 137 232 4.8E-19 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 SUPERFAMILY SSF52833 135 232 3.29E-21 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 Gene3D G3DSA:3.40.250.10 18 126 4.2E-22 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01930 49424e9712b67f5bcca8289ecc94f424 234 PANTHER PTHR10438 135 232 4.7E-18 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 55 183 9.9E-51 T 21-04-2016 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 ProSitePatterns PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 120 133 - T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 Gene3D G3DSA:3.40.192.10 66 187 5.2E-62 T 21-04-2016 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 SUPERFAMILY SSF51735 200 445 3.71E-78 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 PANTHER PTHR11606 1 446 1.4E-248 T 21-04-2016 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 SMART SM00839 202 444 1.5E-89 T 21-04-2016 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 SUPERFAMILY SSF53223 6 194 3.52E-73 T 21-04-2016 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 200 444 9.9E-88 T 21-04-2016 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 PANTHER PTHR11606:SF4 1 446 1.4E-248 T 21-04-2016 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 Gene3D G3DSA:1.10.285.10 371 445 6.6E-25 T 21-04-2016 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 Gene3D G3DSA:1.10.285.10 7 65 3.7E-23 T 21-04-2016 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 PIRSF PIRSF000185 20 446 4.0E-121 T 21-04-2016 IPR014362 Glutamate dehydrogenase GO:0016639|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 233 253 6.3E-32 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 112 126 6.3E-32 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 370 381 6.3E-32 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 191 213 6.3E-32 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS17075 3aa4f94547fa50428500eecee3f6b46b 446 Gene3D G3DSA:3.40.50.720 207 370 1.3E-66 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 Gene3D G3DSA:3.50.50.60 2 59 2.4E-14 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 Pfam PF13450 NAD(P)-binding Rossmann-like domain 10 59 2.3E-8 T 21-04-2016 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 PANTHER PTHR10668 7 476 8.4E-152 T 21-04-2016 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 7 29 8.0E-6 T 21-04-2016 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 212 237 8.0E-6 T 21-04-2016 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 Gene3D G3DSA:3.50.50.60 439 470 3.2E-6 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 Gene3D G3DSA:3.50.50.60 206 283 3.2E-6 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 PANTHER PTHR10668:SF74 7 476 8.4E-152 T 21-04-2016 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 SUPERFAMILY SSF51905 433 470 1.02E-28 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01910 1a96b3590b5b0feefcaac28fea8d1ee5 479 SUPERFAMILY SSF51905 1 299 1.02E-28 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 SUPERFAMILY SSF47781 65 133 6.67E-19 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 Pfam PF14520 Helix-hairpin-helix domain 71 129 1.9E-16 T 21-04-2016 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 SMART SM00278 107 126 0.019 T 21-04-2016 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 SMART SM00278 72 91 200.0 T 21-04-2016 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 TIGRFAM TIGR00084 ruvA: Holliday junction DNA helicase RuvA 1 193 3.4E-45 T 21-04-2016 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 Hamap MF_00031 Holliday junction ATP-dependent DNA helicase RuvA [ruvA]. 1 194 27.208 T 21-04-2016 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 Gene3D G3DSA:1.10.150.20 67 138 1.2E-26 T 21-04-2016 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 Gene3D G3DSA:1.10.8.10 139 194 8.7E-15 T 21-04-2016 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 SUPERFAMILY SSF46929 148 194 3.01E-10 T 21-04-2016 IPR011114 DNA helicase, Holliday junction RuvA type, domain III, C-terminal GO:0005524|GO:0006281|GO:0006310|GO:0009378|GO:0009379 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 SUPERFAMILY SSF50249 1 62 1.77E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 Pfam PF01330 RuvA N terminal domain 1 61 1.8E-21 T 21-04-2016 IPR013849 DNA helicase, Holliday junction RuvA type, domain I, bacterial GO:0005524|GO:0006281|GO:0006310|GO:0009378 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 Pfam PF07499 RuvA, C-terminal domain 150 194 5.0E-12 T 21-04-2016 IPR011114 DNA helicase, Holliday junction RuvA type, domain III, C-terminal GO:0005524|GO:0006281|GO:0006310|GO:0009378|GO:0009379 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 PANTHER PTHR33796 2 194 7.2E-63 T 21-04-2016 SPH21_RS10295 213dbbba9590ebe97f09a0e1949cd39c 194 Gene3D G3DSA:2.40.50.140 1 64 5.9E-24 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Pfam PF07715 TonB-dependent Receptor Plug Domain 143 250 7.7E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Gene3D G3DSA:2.60.40.1120 54 138 1.3E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Pfam PF13715 CarboxypepD_reg-like domain 54 135 2.3E-18 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 PANTHER PTHR11532 544 1056 1.0E-267 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 PANTHER PTHR11532 50 435 1.0E-267 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 PANTHER PTHR11532:SF57 544 1056 1.0E-267 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 PANTHER PTHR11532:SF57 50 435 1.0E-267 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Gene3D G3DSA:2.170.130.10 139 251 5.8E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 SUPERFAMILY SSF49464 52 133 3.4E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Gene3D G3DSA:2.40.170.20 465 819 2.6E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Gene3D G3DSA:2.40.170.20 964 1058 2.6E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Gene3D G3DSA:2.40.170.20 252 270 2.6E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Gene3D G3DSA:2.40.170.20 893 918 2.6E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 Gene3D G3DSA:2.40.170.20 358 433 2.6E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 SUPERFAMILY SSF56935 884 928 9.52E-105 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 SUPERFAMILY SSF56935 966 1058 9.52E-105 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 SUPERFAMILY SSF56935 349 437 9.52E-105 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 SUPERFAMILY SSF56935 472 812 9.52E-105 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 SUPERFAMILY SSF56935 131 274 9.52E-105 T 21-04-2016 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 53 1058 1.4E-282 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS25200 b7030238164f077b077f9e0005bc8b08 1058 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 226 256 4.6E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS05315 6cd7cfafa0b1c1a144713e4e46f03a14 378 Gene3D G3DSA:3.20.20.140 19 377 1.5E-129 T 21-04-2016 SPH21_RS05315 6cd7cfafa0b1c1a144713e4e46f03a14 378 SUPERFAMILY SSF51556 298 377 6.46E-102 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS05315 6cd7cfafa0b1c1a144713e4e46f03a14 378 SUPERFAMILY SSF51556 20 260 6.46E-102 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS05315 6cd7cfafa0b1c1a144713e4e46f03a14 378 PANTHER PTHR10443 17 260 2.1E-119 T 21-04-2016 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533 SPH21_RS05315 6cd7cfafa0b1c1a144713e4e46f03a14 378 PANTHER PTHR10443 298 378 2.1E-119 T 21-04-2016 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533 SPH21_RS05315 6cd7cfafa0b1c1a144713e4e46f03a14 378 ProSitePatterns PS00869 Renal dipeptidase active site. 130 152 - T 21-04-2016 IPR000180 Membrane dipeptidase, active site GO:0006508|GO:0008235|GO:0008239|GO:0016805 MetaCyc: PWY-7533 SPH21_RS05315 6cd7cfafa0b1c1a144713e4e46f03a14 378 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 25 375 7.6E-109 T 21-04-2016 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 215 309 5.5E-29 T 21-04-2016 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 333 448 1.6E-34 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 SUPERFAMILY SSF48179 215 314 1.24E-26 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 SMART SM00984 333 448 3.0E-39 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 Gene3D G3DSA:1.20.5.100 218 243 1.8E-13 T 21-04-2016 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 PANTHER PTHR11374:SF3 1 462 5.5E-303 T 21-04-2016 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 Gene3D G3DSA:3.40.50.720 5 217 1.4E-73 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 SUPERFAMILY SSF52413 318 457 5.49E-33 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 5 191 1.0E-58 T 21-04-2016 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 PIRSF PIRSF000124 4 463 5.2E-130 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 SUPERFAMILY SSF51735 5 207 4.76E-40 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 Gene3D G3DSA:3.40.50.720 247 462 7.3E-87 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 PIRSF PIRSF500133 1 463 6.2E-237 T 21-04-2016 IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type GO:0003979 KEGG: 00040+1.1.1.22|KEGG: 00053+1.1.1.22|KEGG: 00500+1.1.1.22|KEGG: 00520+1.1.1.22|MetaCyc: PWY-7346|UniPathway: UPA00038 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 5 444 2.9E-101 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS09680 6b9b0eff1e7070db4a68623fe504d0b4 463 PANTHER PTHR11374 1 462 5.5E-303 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 Gene3D G3DSA:3.40.50.1100 1 41 1.4E-69 T 21-04-2016 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 Gene3D G3DSA:3.40.50.1100 152 321 1.4E-69 T 21-04-2016 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 SMART SM00116 342 389 2.7E-6 T 21-04-2016 IPR000644 CBS domain SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 SMART SM00116 406 452 19.0 T 21-04-2016 IPR000644 CBS domain SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 ProSitePatterns PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 32 50 - T 21-04-2016 IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site GO:0006535 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 Gene3D G3DSA:3.40.50.1100 42 146 4.7E-35 T 21-04-2016 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 SUPERFAMILY SSF53686 2 324 1.17E-93 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 8 302 1.9E-68 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 PANTHER PTHR10314:SF104 4 358 2.9E-137 T 21-04-2016 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 Gene3D G3DSA:3.10.580.10 340 452 1.0E-19 T 21-04-2016 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 SUPERFAMILY SSF54631 341 451 5.18E-19 T 21-04-2016 SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 Pfam PF00571 CBS domain 342 389 7.6E-7 T 21-04-2016 IPR000644 CBS domain SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 Pfam PF00571 CBS domain 399 452 8.9E-4 T 21-04-2016 IPR000644 CBS domain SPH21_RS14570 b91aad1e6c2dd2b477460b8b02c48403 454 PANTHER PTHR10314 4 358 2.9E-137 T 21-04-2016 SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 110 295 2.4E-52 T 21-04-2016 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 5 324 4.6E-31 T 21-04-2016 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 PANTHER PTHR10996 1 324 3.2E-149 T 21-04-2016 SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 SUPERFAMILY SSF51735 102 296 1.81E-51 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 147 174 - T 21-04-2016 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 Gene3D G3DSA:3.40.50.720 1 137 5.2E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 SUPERFAMILY SSF52283 2 136 2.55E-41 T 21-04-2016 SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 PANTHER PTHR10996:SF161 1 324 3.2E-149 T 21-04-2016 SPH21_RS14415 a614d7fd217d44dd8c5e0b83837fed18 327 Gene3D G3DSA:3.40.50.720 138 302 3.3E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 SUPERFAMILY SSF55347 178 207 2.13E-11 T 21-04-2016 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 SUPERFAMILY SSF55347 242 308 2.13E-11 T 21-04-2016 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 PANTHER PTHR22604 247 368 1.3E-200 T 21-04-2016 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 PANTHER PTHR22604 1 220 1.3E-200 T 21-04-2016 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 PANTHER PTHR22604 386 455 1.3E-200 T 21-04-2016 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 47 166 4.6E-18 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 Gene3D G3DSA:3.40.50.720 45 207 3.3E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 Gene3D G3DSA:3.40.50.720 244 286 3.3E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 SUPERFAMILY SSF51735 40 201 2.4E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 PANTHER PTHR22604:SF112 247 368 1.3E-200 T 21-04-2016 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 PANTHER PTHR22604:SF112 1 220 1.3E-200 T 21-04-2016 SPH21_RS01040 63796e7cc5fe599537c1126226974cf3 477 PANTHER PTHR22604:SF112 386 455 1.3E-200 T 21-04-2016 SPH21_RS11565 cda4d6189fbbb6bdbd114332ef1537e4 147 SUPERFAMILY SSF54637 4 146 7.48E-38 T 21-04-2016 IPR029069 HotDog domain SPH21_RS11565 cda4d6189fbbb6bdbd114332ef1537e4 147 PANTHER PTHR13078 7 142 7.2E-28 T 21-04-2016 SPH21_RS11565 cda4d6189fbbb6bdbd114332ef1537e4 147 Gene3D G3DSA:3.10.129.10 5 146 2.5E-39 T 21-04-2016 IPR029069 HotDog domain SPH21_RS11565 cda4d6189fbbb6bdbd114332ef1537e4 147 Pfam PF01575 MaoC like domain 16 123 1.3E-21 T 21-04-2016 IPR002539 MaoC-like domain SPH21_RS07305 8558dd4d34bfb4f70272abc489faacbe 82 Gene3D G3DSA:3.40.1440.10 4 35 3.7E-6 T 21-04-2016 IPR027299 GIY-YIG domain SPH21_RS07305 8558dd4d34bfb4f70272abc489faacbe 82 Pfam PF01541 GIY-YIG catalytic domain 4 69 1.3E-15 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS07305 8558dd4d34bfb4f70272abc489faacbe 82 SUPERFAMILY SSF82771 3 71 4.05E-14 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 Pfam PF13419 Haloacid dehalogenase-like hydrolase 9 205 7.1E-28 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 SUPERFAMILY SSF56784 6 216 7.85E-45 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 110 201 2.5E-12 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 Gene3D G3DSA:3.40.50.1000 98 228 7.3E-36 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 Gene3D G3DSA:1.10.150.240 18 97 3.4E-15 T 21-04-2016 IPR023198 Phosphoglycolate phosphatase, domain 2 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 5 16 7.2E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 168 188 7.2E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 119 132 7.2E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 150 166 7.2E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 PANTHER PTHR12725:SF57 8 211 1.2E-36 T 21-04-2016 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 PANTHER PTHR12725 8 211 1.2E-36 T 21-04-2016 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 TIGRFAM TIGR02254 YjjG/YfnB: noncanonical pyrimidine nucleotidase, YjjG family 5 229 2.2E-59 T 21-04-2016 IPR011951 HAD-superfamily hydrolase, subfamily IA, YjjG/YfnB GO:0016787 SPH21_RS03570 6a14e86fdedf486b2451b84525debd93 232 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 141 205 1.4E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 SMART SM00917 372 503 1.6E-27 T 21-04-2016 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 SUPERFAMILY SSF110921 394 501 1.44E-21 T 21-04-2016 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 TIGRFAM TIGR00973 leuA_bact: 2-isopropylmalate synthase 8 500 3.2E-204 T 21-04-2016 IPR005671 2-isopropylmalate synthase, bacterial-type GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 Hamap MF_01025 2-isopropylmalate synthase [leuA]. 5 503 39.162 T 21-04-2016 IPR005671 2-isopropylmalate synthase, bacterial-type GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 SUPERFAMILY SSF51569 3 294 5.49E-95 T 21-04-2016 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 ProSitePatterns PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 202 215 - T 21-04-2016 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 PANTHER PTHR10277:SF9 1 503 2.7E-231 T 21-04-2016 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 Pfam PF00682 HMGL-like 8 276 8.5E-91 T 21-04-2016 IPR000891 Pyruvate carboxyltransferase GO:0003824 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 PANTHER PTHR10277 1 503 2.7E-231 T 21-04-2016 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 Gene3D G3DSA:3.20.20.70 5 350 4.7E-142 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 15 31 - T 21-04-2016 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11245 adb2f12a924ca6dc924a0a00d7c6f369 503 Pfam PF08502 LeuA allosteric (dimerisation) domain 372 502 5.9E-33 T 21-04-2016 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS25105 b0980dab51dc64a7b017ddf43c127a00 365 Pfam PF01757 Acyltransferase family 20 340 5.8E-28 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS25105 b0980dab51dc64a7b017ddf43c127a00 365 PANTHER PTHR23028 11 361 6.3E-72 T 21-04-2016 SPH21_RS25105 b0980dab51dc64a7b017ddf43c127a00 365 PANTHER PTHR23028:SF54 11 361 6.3E-72 T 21-04-2016 SPH21_RS24510 b02aca59a9ad8f318f09e78ed7a01277 398 PANTHER PTHR33258 7 352 1.2E-47 T 21-04-2016 SPH21_RS24510 b02aca59a9ad8f318f09e78ed7a01277 398 PANTHER PTHR33258:SF1 7 352 1.2E-47 T 21-04-2016 SPH21_RS24510 b02aca59a9ad8f318f09e78ed7a01277 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS24510 b02aca59a9ad8f318f09e78ed7a01277 398 Pfam PF14294 Domain of unknown function (DUF4372) 8 81 3.6E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS24510 b02aca59a9ad8f318f09e78ed7a01277 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS24510 b02aca59a9ad8f318f09e78ed7a01277 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS08300 b02aca59a9ad8f318f09e78ed7a01277 398 PANTHER PTHR33258 7 352 1.2E-47 T 21-04-2016 SPH21_RS08300 b02aca59a9ad8f318f09e78ed7a01277 398 PANTHER PTHR33258:SF1 7 352 1.2E-47 T 21-04-2016 SPH21_RS08300 b02aca59a9ad8f318f09e78ed7a01277 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS08300 b02aca59a9ad8f318f09e78ed7a01277 398 Pfam PF14294 Domain of unknown function (DUF4372) 8 81 3.6E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS08300 b02aca59a9ad8f318f09e78ed7a01277 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS08300 b02aca59a9ad8f318f09e78ed7a01277 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS01670 b02aca59a9ad8f318f09e78ed7a01277 398 PANTHER PTHR33258 7 352 1.2E-47 T 21-04-2016 SPH21_RS01670 b02aca59a9ad8f318f09e78ed7a01277 398 PANTHER PTHR33258:SF1 7 352 1.2E-47 T 21-04-2016 SPH21_RS01670 b02aca59a9ad8f318f09e78ed7a01277 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS01670 b02aca59a9ad8f318f09e78ed7a01277 398 Pfam PF14294 Domain of unknown function (DUF4372) 8 81 3.6E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS01670 b02aca59a9ad8f318f09e78ed7a01277 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS01670 b02aca59a9ad8f318f09e78ed7a01277 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 Gene3D G3DSA:1.20.1560.10 150 461 1.6E-71 T 21-04-2016 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 Pfam PF00005 ABC transporter 494 642 7.0E-30 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 SUPERFAMILY SSF90123 150 462 6.02E-69 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 Pfam PF03412 Peptidase C39 family 6 136 1.4E-34 T 21-04-2016 IPR005074 Peptidase C39, bacteriocin processing GO:0005524|GO:0006508|GO:0008233|GO:0016021 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 ProSitePatterns PS00211 ABC transporters family signature. 614 628 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 SUPERFAMILY SSF52540 466 713 5.03E-82 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 SMART SM00382 502 689 4.6E-19 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 Pfam PF00664 ABC transporter transmembrane region 165 432 2.1E-42 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 Gene3D G3DSA:3.40.50.300 477 709 2.2E-77 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 PANTHER PTHR24221 149 722 1.9E-189 T 21-04-2016 SPH21_RS09365 f565b0e645e3d56ef645963364c87418 722 Gene3D G3DSA:3.90.70.10 9 134 9.3E-27 T 21-04-2016 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Gene3D G3DSA:3.30.565.10 361 515 4.2E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SUPERFAMILY SSF47384 281 361 2.35E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SMART SM00086 109 151 1.8E-5 T 21-04-2016 IPR001610 PAC motif SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Gene3D G3DSA:3.30.450.20 31 148 4.3E-19 T 21-04-2016 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Pfam PF00512 His Kinase A (phospho-acceptor) domain 293 360 1.1E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 PRINTS PR00344 Bacterial sensor protein C-terminal signature 479 497 1.7E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 PRINTS PR00344 Bacterial sensor protein C-terminal signature 462 472 1.7E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 PRINTS PR00344 Bacterial sensor protein C-terminal signature 444 458 1.7E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 PRINTS PR00344 Bacterial sensor protein C-terminal signature 503 516 1.7E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SUPERFAMILY SSF55785 46 154 1.15E-15 T 21-04-2016 IPR000014 PAS domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 PANTHER PTHR24423 32 515 3.5E-110 T 21-04-2016 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 403 518 4.1E-25 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SUPERFAMILY SSF55785 147 281 7.5E-21 T 21-04-2016 IPR000014 PAS domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Gene3D G3DSA:3.30.450.20 149 283 1.5E-20 T 21-04-2016 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Pfam PF08448 PAS fold 178 287 3.8E-13 T 21-04-2016 IPR013656 PAS fold-4 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SMART SM00388 292 360 1.1E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SUPERFAMILY SSF55874 350 515 2.49E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 81 158 3.2E-10 T 21-04-2016 IPR000014 PAS domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 167 291 4.3E-10 T 21-04-2016 IPR000014 PAS domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SMART SM00091 39 103 31.0 T 21-04-2016 IPR000014 PAS domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SMART SM00091 170 238 0.0041 T 21-04-2016 IPR000014 PAS domain SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Gene3D G3DSA:1.10.287.130 284 356 2.3E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 Pfam PF08447 PAS fold 78 144 3.1E-9 T 21-04-2016 IPR013655 PAS fold-3 GO:0005515 SPH21_RS23360 8fca728dd95767ebfb572fc94083a1cc 519 SMART SM00387 403 519 1.8E-36 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 PANTHER PTHR30154 5 157 4.4E-52 T 21-04-2016 SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 PANTHER PTHR30154:SF28 5 157 4.4E-52 T 21-04-2016 SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 SMART SM00344 13 122 4.3E-40 T 21-04-2016 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 SUPERFAMILY SSF46785 11 101 4.66E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 Pfam PF01037 Lrp/AsnC ligand binding domain 81 152 3.8E-20 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 13 29 1.2E-12 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 40 59 1.2E-12 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 29 40 1.2E-12 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 Pfam PF13412 Winged helix-turn-helix DNA-binding 13 60 5.1E-18 T 21-04-2016 SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 Gene3D G3DSA:1.10.10.10 9 64 2.1E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 Gene3D G3DSA:3.30.70.920 66 157 1.9E-24 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS13875 7eb98bafa77f002eee02c58f41480c1d 166 SUPERFAMILY SSF54909 75 157 2.28E-19 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 SUPERFAMILY SSF117281 23 213 2.48E-39 T 21-04-2016 SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 PANTHER PTHR24412:SF244 17 275 1.5E-24 T 21-04-2016 SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 Gene3D G3DSA:2.120.10.80 232 316 7.4E-10 T 21-04-2016 IPR015915 Kelch-type beta propeller GO:0005515 SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 Gene3D G3DSA:2.120.10.80 23 212 4.0E-39 T 21-04-2016 IPR015915 Kelch-type beta propeller GO:0005515 SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 Pfam PF13418 Galactose oxidase, central domain 33 77 3.7E-8 T 21-04-2016 SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 PANTHER PTHR24412 17 275 1.5E-24 T 21-04-2016 SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 SUPERFAMILY SSF117281 233 315 1.22E-10 T 21-04-2016 SPH21_RS17045 2f6175f150f40e030d86cad27d552701 322 Pfam PF13415 Galactose oxidase, central domain 98 134 2.7E-5 T 21-04-2016 SPH21_RS00405 242f71af2fd7639fadeb00ac59606ba1 394 PANTHER PTHR30341 8 394 3.5E-146 T 21-04-2016 SPH21_RS00405 242f71af2fd7639fadeb00ac59606ba1 394 Gene3D G3DSA:1.20.1530.10 9 389 3.7E-145 T 21-04-2016 IPR023171 Na/H antiporter domain SPH21_RS00405 242f71af2fd7639fadeb00ac59606ba1 394 Hamap MF_01844 Na(+)/H(+) antiporter NhaA [nhaA]. 10 389 22.338 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS00405 242f71af2fd7639fadeb00ac59606ba1 394 Pfam PF06965 Na+/H+ antiporter 1 12 383 2.0E-144 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS00405 242f71af2fd7639fadeb00ac59606ba1 394 PANTHER PTHR30341:SF0 8 394 3.5E-146 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS00405 242f71af2fd7639fadeb00ac59606ba1 394 TIGRFAM TIGR00773 NhaA: Na+/H+ antiporter NhaA 13 383 3.3E-127 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS09070 64de4ff77734debe437f7c2aa734957e 636 Gene3D G3DSA:3.90.25.10 476 556 1.7E-7 T 21-04-2016 SPH21_RS09070 64de4ff77734debe437f7c2aa734957e 636 Pfam PF02719 Polysaccharide biosynthesis protein 294 579 1.1E-120 T 21-04-2016 IPR003869 Polysaccharide biosynthesis protein, CapD-like domain SPH21_RS09070 64de4ff77734debe437f7c2aa734957e 636 SUPERFAMILY SSF51735 291 558 3.36E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09070 64de4ff77734debe437f7c2aa734957e 636 Gene3D G3DSA:3.40.50.720 292 475 1.8E-48 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09070 64de4ff77734debe437f7c2aa734957e 636 PANTHER PTHR10366:SF256 293 564 1.3E-116 T 21-04-2016 SPH21_RS09070 64de4ff77734debe437f7c2aa734957e 636 PANTHER PTHR10366 293 564 1.3E-116 T 21-04-2016 SPH21_RS09070 64de4ff77734debe437f7c2aa734957e 636 Gene3D G3DSA:3.40.50.720 143 222 1.9E-5 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 TIGRFAM TIGR00857 pyrC_multi: dihydroorotase, multifunctional complex type 23 419 7.6E-105 T 21-04-2016 IPR004722 Dihydroorotase GO:0004151|GO:0006221|GO:0046872 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 Hamap MF_00220_B Dihydroorotase [pyrC]. 3 423 33.654 T 21-04-2016 IPR004722 Dihydroorotase GO:0004151|GO:0006221|GO:0046872 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 Pfam PF01979 Amidohydrolase family 56 400 1.4E-10 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 Gene3D G3DSA:3.20.20.140 73 386 2.5E-85 T 21-04-2016 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 Gene3D G3DSA:2.30.40.10 3 72 1.2E-14 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 PANTHER PTHR11647 1 413 8.9E-130 T 21-04-2016 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 PANTHER PTHR11647:SF70 1 413 8.9E-130 T 21-04-2016 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 SUPERFAMILY SSF51556 59 364 4.27E-85 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 SUPERFAMILY SSF51338 365 418 1.17E-19 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS25275 ab4b9fa1e101d39ad75da9011e128df9 423 SUPERFAMILY SSF51338 2 58 1.17E-19 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09045 a12a0cfba5b96c059452bd1e5af0a7b3 371 Gene3D G3DSA:3.40.50.2000 1 203 2.0E-73 T 21-04-2016 SPH21_RS09045 a12a0cfba5b96c059452bd1e5af0a7b3 371 Pfam PF02350 UDP-N-acetylglucosamine 2-epimerase 32 358 7.1E-103 T 21-04-2016 IPR003331 UDP-N-acetylglucosamine 2-epimerase domain SPH21_RS09045 a12a0cfba5b96c059452bd1e5af0a7b3 371 TIGRFAM TIGR00236 wecB: UDP-N-acetylglucosamine 2-epimerase 1 360 8.6E-98 T 21-04-2016 IPR029767 UDP-N-acetylglucosamine 2-epimerase WecB-like GO:0008761 KEGG: 00520+5.1.3.14|MetaCyc: PWY-7335 SPH21_RS09045 a12a0cfba5b96c059452bd1e5af0a7b3 371 SUPERFAMILY SSF53756 1 363 7.85E-109 T 21-04-2016 SPH21_RS09045 a12a0cfba5b96c059452bd1e5af0a7b3 371 PANTHER PTHR18964 1 364 1.6E-99 T 21-04-2016 SPH21_RS09045 a12a0cfba5b96c059452bd1e5af0a7b3 371 Gene3D G3DSA:3.40.50.2000 204 359 1.2E-53 T 21-04-2016 SPH21_RS09045 a12a0cfba5b96c059452bd1e5af0a7b3 371 PANTHER PTHR18964:SF70 1 364 1.6E-99 T 21-04-2016 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Gene3D G3DSA:1.10.287.110 1 96 6.1E-38 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Pfam PF00684 DnaJ central domain 151 215 4.0E-13 T 21-04-2016 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 PRINTS PR00625 DnaJ domain signature 62 81 4.4E-31 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 PRINTS PR00625 DnaJ domain signature 42 62 4.4E-31 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 PRINTS PR00625 DnaJ domain signature 7 25 4.4E-31 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 PRINTS PR00625 DnaJ domain signature 25 40 4.4E-31 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 PANTHER PTHR24078:SF190 1 357 9.0E-153 T 21-04-2016 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 SMART SM00271 4 62 7.6E-33 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 SUPERFAMILY SSF49493 267 352 2.09E-22 T 21-04-2016 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Gene3D G3DSA:2.60.260.20 114 144 5.5E-18 T 21-04-2016 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Gene3D G3DSA:2.60.260.20 218 261 5.5E-18 T 21-04-2016 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 SUPERFAMILY SSF49493 221 265 7.06E-18 T 21-04-2016 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 SUPERFAMILY SSF49493 123 156 7.06E-18 T 21-04-2016 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 SUPERFAMILY SSF57938 138 218 6.67E-19 T 21-04-2016 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Gene3D G3DSA:2.60.260.20 264 342 1.3E-20 T 21-04-2016 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Hamap MF_01152 Chaperone protein DnaJ [dnaJ]. 2 379 38.785 T 21-04-2016 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Pfam PF01556 DnaJ C terminal domain 125 341 8.4E-40 T 21-04-2016 IPR002939 Chaperone DnaJ, C-terminal SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 SUPERFAMILY SSF46565 1 101 7.72E-37 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 TIGRFAM TIGR02349 DnaJ_bact: chaperone protein DnaJ 5 357 1.5E-133 T 21-04-2016 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Gene3D G3DSA:2.10.230.10 145 217 1.3E-19 T 21-04-2016 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 Pfam PF00226 DnaJ domain 5 67 6.9E-29 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 PANTHER PTHR24078 1 357 9.0E-153 T 21-04-2016 SPH21_RS15525 b33f8482503173870091e36fc23211a1 381 ProSitePatterns PS00636 Nt-dnaJ domain signature. 47 66 - T 21-04-2016 IPR018253 DnaJ domain, conserved site SPH21_RS00915 b1d88d136515e661e5ada5e162d7bf73 220 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 6 104 4.0E-10 T 21-04-2016 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SPH21_RS00915 b1d88d136515e661e5ada5e162d7bf73 220 Gene3D G3DSA:3.40.50.720 6 212 7.2E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00915 b1d88d136515e661e5ada5e162d7bf73 220 SUPERFAMILY SSF51735 6 211 6.29E-37 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00915 b1d88d136515e661e5ada5e162d7bf73 220 PANTHER PTHR14239 4 201 2.8E-32 T 21-04-2016 SPH21_RS12345 6fe1441fe5d69bc26d14ee26edfe711d 313 PANTHER PTHR11019:SF45 42 313 4.6E-16 T 21-04-2016 SPH21_RS12345 6fe1441fe5d69bc26d14ee26edfe711d 313 SMART SM00342 229 312 2.8E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12345 6fe1441fe5d69bc26d14ee26edfe711d 313 PANTHER PTHR11019 42 313 4.6E-16 T 21-04-2016 SPH21_RS12345 6fe1441fe5d69bc26d14ee26edfe711d 313 Pfam PF12833 Helix-turn-helix domain 235 312 4.8E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12345 6fe1441fe5d69bc26d14ee26edfe711d 313 SUPERFAMILY SSF46689 268 312 1.88E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12345 6fe1441fe5d69bc26d14ee26edfe711d 313 Gene3D G3DSA:1.10.10.60 268 312 4.5E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS11450 d74bbcb24162625c4e96db657c550b80 285 Pfam PF13715 CarboxypepD_reg-like domain 29 90 2.6E-10 T 21-04-2016 SPH21_RS11450 d74bbcb24162625c4e96db657c550b80 285 SUPERFAMILY SSF49464 28 90 2.49E-9 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS11450 d74bbcb24162625c4e96db657c550b80 285 Gene3D G3DSA:2.60.40.1120 29 91 3.3E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 SMART SM00316 635 706 1.1E-25 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 PANTHER PTHR10724:SF1 5 720 0.0 T 21-04-2016 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Pfam PF12836 Helix-hairpin-helix motif 477 541 2.9E-27 T 21-04-2016 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 SMART SM00732 315 410 5.9E-28 T 21-04-2016 IPR006641 YqgF/RNase H-like domain GO:0006139 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 SUPERFAMILY SSF47781 456 543 6.89E-28 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Pfam PF00575 S1 RNA binding domain 634 706 1.4E-22 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 PANTHER PTHR10724 5 720 0.0 T 21-04-2016 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 SUPERFAMILY SSF47781 546 617 6.23E-19 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Gene3D G3DSA:1.10.3500.10 109 311 8.4E-93 T 21-04-2016 IPR023323 Tex-like domain SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Gene3D G3DSA:1.10.3500.10 437 484 8.4E-93 T 21-04-2016 IPR023323 Tex-like domain SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Pfam PF16921 Tex protein YqgF-like domain 316 436 5.5E-47 T 21-04-2016 IPR032639 Tex protein, YqgF-like domain SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Gene3D G3DSA:3.30.420.140 315 436 5.4E-48 T 21-04-2016 IPR006641 YqgF/RNase H-like domain GO:0006139 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Pfam PF09371 Tex-like protein N-terminal domain 8 191 2.3E-67 T 21-04-2016 IPR018974 Tex-like protein, N-terminal SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Gene3D G3DSA:2.40.50.140 629 707 2.5E-28 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 SUPERFAMILY SSF50249 624 712 1.27E-25 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Gene3D G3DSA:1.10.10.650 4 108 2.4E-39 T 21-04-2016 IPR023319 Tex-like protein, HTH domain SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 Gene3D G3DSA:1.10.150.310 485 616 1.9E-48 T 21-04-2016 IPR023097 Tex RuvX-like domain SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 SUPERFAMILY SSF158832 3 310 1.15E-108 T 21-04-2016 SPH21_RS12595 8483e2fe85f682f868b73a59aea6f26b 746 SUPERFAMILY SSF53098 311 455 7.59E-47 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 Pfam PF02913 FAD linked oxidases, C-terminal domain 300 526 9.0E-37 T 21-04-2016 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 Gene3D G3DSA:3.30.465.10 226 277 1.6E-32 T 21-04-2016 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 Gene3D G3DSA:3.30.465.10 102 191 1.6E-32 T 21-04-2016 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 Pfam PF13534 4Fe-4S dicluster domain 565 643 9.7E-10 T 21-04-2016 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 SUPERFAMILY SSF56176 30 277 6.54E-50 T 21-04-2016 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 Pfam PF01565 FAD binding domain 47 180 1.4E-33 T 21-04-2016 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 SUPERFAMILY SSF55103 294 530 1.6E-40 T 21-04-2016 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 Gene3D G3DSA:1.10.1060.10 505 660 1.2E-14 T 21-04-2016 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 PANTHER PTHR11748:SF35 244 575 1.5E-100 T 21-04-2016 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 PANTHER PTHR11748:SF35 5 190 1.5E-100 T 21-04-2016 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 628 639 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 SUPERFAMILY SSF46548 555 648 1.7E-10 T 21-04-2016 IPR009051 Alpha-helical ferredoxin GO:0051536 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 Gene3D G3DSA:3.30.43.10 30 101 4.6E-15 T 21-04-2016 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 PANTHER PTHR11748 244 575 1.5E-100 T 21-04-2016 SPH21_RS19120 78f75c1b5f6495bf4d9f3660ce170c25 976 PANTHER PTHR11748 5 190 1.5E-100 T 21-04-2016 SPH21_RS02345 d37796d01fa80dbb0989c1350caea1ec 501 Gene3D G3DSA:1.25.40.10 353 439 1.2E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02345 d37796d01fa80dbb0989c1350caea1ec 501 Gene3D G3DSA:1.25.40.10 203 309 1.2E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02345 d37796d01fa80dbb0989c1350caea1ec 501 SUPERFAMILY SSF48452 15 501 3.79E-106 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02345 d37796d01fa80dbb0989c1350caea1ec 501 Pfam PF14322 Starch-binding associating with outer membrane 21 221 5.1E-23 T 21-04-2016 SPH21_RS02345 d37796d01fa80dbb0989c1350caea1ec 501 Pfam PF07980 SusD family 348 501 2.5E-22 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 Gene3D G3DSA:2.60.120.280 39 134 1.7E-4 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 Pfam PF12833 Helix-turn-helix domain 199 278 7.8E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 SMART SM00342 195 276 3.1E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 PANTHER PTHR11019 15 280 5.7E-41 T 21-04-2016 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 PANTHER PTHR11019:SF45 15 280 5.7E-41 T 21-04-2016 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 Gene3D G3DSA:1.10.10.60 235 279 2.2E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 Pfam PF02311 AraC-like ligand binding domain 38 133 1.9E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 SUPERFAMILY SSF46689 234 280 1.79E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 260 276 2.8E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 245 260 2.8E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS11180 8f9c261aae29a6137ff54bdab3b5e95a 281 SUPERFAMILY SSF51215 37 108 3.53E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS16485 a95d5178309cbf827a18c2486a943d5a 288 SUPERFAMILY SSF53474 67 277 4.34E-20 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16485 a95d5178309cbf827a18c2486a943d5a 288 PANTHER PTHR10992 69 156 4.3E-12 T 21-04-2016 SPH21_RS16485 a95d5178309cbf827a18c2486a943d5a 288 PANTHER PTHR10992:SF701 69 156 4.3E-12 T 21-04-2016 SPH21_RS16485 a95d5178309cbf827a18c2486a943d5a 288 Gene3D G3DSA:3.40.50.1820 67 179 9.2E-18 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16485 a95d5178309cbf827a18c2486a943d5a 288 Gene3D G3DSA:3.40.50.1820 216 280 9.2E-18 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16485 a95d5178309cbf827a18c2486a943d5a 288 Pfam PF00561 alpha/beta hydrolase fold 80 217 2.3E-10 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS18980 dc6e3533b5e2fa227d1b247208efe288 172 SUPERFAMILY SSF55729 4 146 9.57E-17 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS18980 dc6e3533b5e2fa227d1b247208efe288 172 Gene3D G3DSA:3.40.630.30 5 162 9.6E-15 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS18980 dc6e3533b5e2fa227d1b247208efe288 172 Pfam PF13302 Acetyltransferase (GNAT) domain 9 144 1.5E-12 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Gene3D G3DSA:3.40.50.1000 464 509 6.4E-52 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Gene3D G3DSA:3.40.50.1000 617 757 6.4E-52 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 SUPERFAMILY SSF81665 392 485 5.89E-16 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 SUPERFAMILY SSF81665 209 294 5.89E-16 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00941 Cadmium-transporting ATPase signature 376 390 1.1E-6 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00941 Cadmium-transporting ATPase signature 87 108 1.1E-6 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00941 Cadmium-transporting ATPase signature 357 373 1.1E-6 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00941 Cadmium-transporting ATPase signature 76 85 1.1E-6 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 495 501 - T 21-04-2016 IPR018303 P-type ATPase, phosphorylation site SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 SUPERFAMILY SSF56784 492 511 4.25E-55 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 SUPERFAMILY SSF56784 546 796 4.25E-55 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Pfam PF00122 E1-E2 ATPase 261 484 2.8E-67 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 SUPERFAMILY SSF55008 6 70 1.26E-8 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PANTHER PTHR24093 19 806 1.4E-260 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Pfam PF00403 Heavy-metal-associated domain 76 136 4.0E-12 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 SUPERFAMILY SSF55008 73 141 6.15E-17 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 712 724 1.3E-19 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 689 708 1.3E-19 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 636 646 1.3E-19 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 341 355 1.3E-19 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 493 507 1.3E-19 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Gene3D G3DSA:3.30.70.100 7 70 1.7E-8 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Gene3D G3DSA:3.30.70.100 74 139 1.2E-17 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 221 798 2.5E-187 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Gene3D G3DSA:3.40.1110.10 516 616 3.9E-13 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 262 767 5.6E-92 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 203 799 5.9E-186 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Gene3D G3DSA:2.70.150.10 253 392 3.7E-33 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 PANTHER PTHR24093:SF50 19 806 1.4E-260 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 Pfam PF00702 haloacid dehalogenase-like hydrolase 489 703 7.2E-43 T 21-04-2016 SPH21_RS21050 86f213e0e3c9cc94794fc4f7a7bfd3d9 808 SUPERFAMILY SSF81653 293 391 1.44E-26 T 21-04-2016 SPH21_RS09855 46347d533f71fef8f404341bd1e615c8 759 PANTHER PTHR22762 542 683 6.6E-24 T 21-04-2016 SPH21_RS09855 46347d533f71fef8f404341bd1e615c8 759 SUPERFAMILY SSF51011 584 670 4.46E-12 T 21-04-2016 SPH21_RS09855 46347d533f71fef8f404341bd1e615c8 759 Pfam PF01055 Glycosyl hydrolases family 31 218 676 9.3E-24 T 21-04-2016 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 SPH21_RS09855 46347d533f71fef8f404341bd1e615c8 759 SUPERFAMILY SSF51445 251 579 3.47E-9 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS12955 acfd67cf4779b2a7fcc873856ec0e594 195 PANTHER PTHR24567:SF33 10 195 1.6E-28 T 21-04-2016 SPH21_RS12955 acfd67cf4779b2a7fcc873856ec0e594 195 Gene3D G3DSA:1.10.10.10 147 192 3.4E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12955 acfd67cf4779b2a7fcc873856ec0e594 195 SUPERFAMILY SSF51206 19 143 9.69E-24 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS12955 acfd67cf4779b2a7fcc873856ec0e594 195 PANTHER PTHR24567 10 195 1.6E-28 T 21-04-2016 SPH21_RS12955 acfd67cf4779b2a7fcc873856ec0e594 195 Pfam PF00027 Cyclic nucleotide-binding domain 29 110 8.5E-11 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS12955 acfd67cf4779b2a7fcc873856ec0e594 195 Pfam PF13545 Crp-like helix-turn-helix domain 156 191 1.3E-6 T 21-04-2016 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SPH21_RS12955 acfd67cf4779b2a7fcc873856ec0e594 195 Gene3D G3DSA:2.60.120.10 2 146 1.0E-31 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 SUPERFAMILY SSF49464 50 139 5.49E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Pfam PF13715 CarboxypepD_reg-like domain 50 131 2.4E-18 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 50 1046 5.9E-275 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 223 252 1.1E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Pfam PF07715 TonB-dependent Receptor Plug Domain 140 246 1.6E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Gene3D G3DSA:2.40.170.20 889 1046 5.1E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Gene3D G3DSA:2.40.170.20 338 407 5.1E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Gene3D G3DSA:2.40.170.20 250 270 5.1E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Gene3D G3DSA:2.40.170.20 452 835 5.1E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Gene3D G3DSA:2.60.40.1120 50 139 2.0E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 PANTHER PTHR11532 403 445 1.3E-278 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 PANTHER PTHR11532 535 1044 1.3E-278 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 PANTHER PTHR11532 46 387 1.3E-278 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 SUPERFAMILY SSF56935 450 816 9.46E-85 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 SUPERFAMILY SSF56935 128 270 9.46E-85 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 SUPERFAMILY SSF56935 883 925 9.46E-85 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 SUPERFAMILY SSF56935 331 421 9.46E-85 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 SUPERFAMILY SSF56935 962 1046 9.46E-85 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 PANTHER PTHR11532:SF57 403 445 1.3E-278 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 PANTHER PTHR11532:SF57 535 1044 1.3E-278 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 PANTHER PTHR11532:SF57 46 387 1.3E-278 T 21-04-2016 SPH21_RS09760 cc41cabc595e6743ab8c13049357fc56 1046 Gene3D G3DSA:2.170.130.10 140 249 2.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 TIGRFAM TIGR00885 fucP: L-fucose:H+ symporter permease 21 422 8.0E-107 T 21-04-2016 IPR005275 L-fucose permease FucP GO:0015150|GO:0015756 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 Gene3D G3DSA:1.20.1250.20 25 235 2.3E-22 T 21-04-2016 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 SUPERFAMILY SSF103473 18 421 7.06E-45 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 PANTHER PTHR23514:SF7 10 183 7.6E-120 T 21-04-2016 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 PANTHER PTHR23514:SF7 201 422 7.6E-120 T 21-04-2016 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 Pfam PF07690 Major Facilitator Superfamily 32 379 1.2E-26 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 Gene3D G3DSA:1.20.1250.20 238 418 1.6E-8 T 21-04-2016 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 PANTHER PTHR23514 10 183 7.6E-120 T 21-04-2016 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 PANTHER PTHR23514 201 422 7.6E-120 T 21-04-2016 SPH21_RS11570 df612e6796fa84e61f02036a5928104c 429 TIGRFAM TIGR01272 gluP: glucose/galactose transporter WARNING 105 419 9.7E-64 T 21-04-2016 IPR005964 Bacterial glucose/galactose transporter GO:0005354|GO:0005355|GO:0009276|GO:0015757|GO:0015758|GO:0016021 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 SMART SM00642 195 544 2.0E-4 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 Pfam PF00128 Alpha amylase, catalytic domain 219 315 3.0E-5 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 PANTHER PTHR10357 4 133 3.6E-183 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 PANTHER PTHR10357 162 645 3.6E-183 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 Hamap MF_02124 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase [glgE]. 6 647 43.549 T 21-04-2016 IPR026585 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase GO:0016757 KEGG: 00500+2.4.99.16 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 SUPERFAMILY SSF51445 182 551 4.7E-78 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 Pfam PF11896 Domain of unknown function (DUF3416) 8 189 1.5E-47 T 21-04-2016 IPR021828 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S GO:0004553 KEGG: 00500+2.4.99.16 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 PANTHER PTHR10357:SF137 4 133 3.6E-183 T 21-04-2016 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 PANTHER PTHR10357:SF137 162 645 3.6E-183 T 21-04-2016 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 Gene3D G3DSA:3.20.20.80 162 549 6.5E-61 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 Gene3D G3DSA:3.20.20.80 61 112 6.5E-61 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10735 b00aaf1e0e8a67eff0d996d1f0f83c45 647 Gene3D G3DSA:2.60.40.1180 556 636 8.9E-5 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS18005 cf576fa06583acca0fcf0121bf92c3ac 254 Gene3D G3DSA:3.40.50.150 22 238 2.0E-25 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18005 cf576fa06583acca0fcf0121bf92c3ac 254 SUPERFAMILY SSF53335 11 161 3.65E-27 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18005 cf576fa06583acca0fcf0121bf92c3ac 254 Pfam PF08241 Methyltransferase domain 47 138 1.8E-15 T 21-04-2016 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SPH21_RS18005 cf576fa06583acca0fcf0121bf92c3ac 254 PANTHER PTHR10108:SF730 9 239 5.6E-26 T 21-04-2016 SPH21_RS18005 cf576fa06583acca0fcf0121bf92c3ac 254 PANTHER PTHR10108 9 239 5.6E-26 T 21-04-2016 SPH21_RS15345 a85624523e3a920569f6609c93dec347 283 Pfam PF13650 Aspartyl protease 36 122 3.6E-10 T 21-04-2016 SPH21_RS15345 a85624523e3a920569f6609c93dec347 283 SUPERFAMILY SSF50630 28 109 3.6E-7 T 21-04-2016 IPR021109 Aspartic peptidase domain SPH21_RS02675 5f374d7aae8604969e2d4b87b66461e1 162 Pfam PF01047 MarR family 46 96 3.8E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS02675 5f374d7aae8604969e2d4b87b66461e1 162 SMART SM00347 30 131 7.2E-5 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS02675 5f374d7aae8604969e2d4b87b66461e1 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 73 88 6.5E-5 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS02675 5f374d7aae8604969e2d4b87b66461e1 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 56 72 6.5E-5 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS02675 5f374d7aae8604969e2d4b87b66461e1 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 92 108 6.5E-5 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS02675 5f374d7aae8604969e2d4b87b66461e1 162 SUPERFAMILY SSF46785 13 139 2.81E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02675 5f374d7aae8604969e2d4b87b66461e1 162 Gene3D G3DSA:1.10.10.10 13 128 3.3E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 SUPERFAMILY SSF56935 514 881 2.01E-79 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 SUPERFAMILY SSF56935 947 989 2.01E-79 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 SUPERFAMILY SSF56935 195 337 2.01E-79 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 SUPERFAMILY SSF56935 394 484 2.01E-79 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 SUPERFAMILY SSF56935 1023 1073 2.01E-79 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Gene3D G3DSA:2.170.130.10 202 312 6.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Gene3D G3DSA:2.40.170.20 954 1112 7.8E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Gene3D G3DSA:2.40.170.20 313 335 7.8E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Gene3D G3DSA:2.40.170.20 403 901 7.8E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 290 319 5.3E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 PANTHER PTHR11532 604 1110 2.3E-270 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 PANTHER PTHR11532 114 509 2.3E-270 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 PANTHER PTHR11532:SF57 604 1110 2.3E-270 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 PANTHER PTHR11532:SF57 114 509 2.3E-270 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Pfam PF07715 TonB-dependent Receptor Plug Domain 206 313 2.8E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 118 1112 8.2E-268 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 SUPERFAMILY SSF49464 117 196 3.79E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Gene3D G3DSA:2.60.40.1120 118 201 1.5E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Pfam PF13715 CarboxypepD_reg-like domain 118 198 8.8E-18 T 21-04-2016 SPH21_RS09485 29a043f5866e9211a16b1f28d59d24f0 1112 Pfam PF00593 TonB dependent receptor 706 1110 3.2E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14125 55b0e1a28552e59f2bbdd7a815303fc3 386 Pfam PF08840 BAAT / Acyl-CoA thioester hydrolase C terminal 217 272 2.1E-6 T 21-04-2016 IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal SPH21_RS14125 55b0e1a28552e59f2bbdd7a815303fc3 386 SUPERFAMILY SSF53474 69 377 3.0E-21 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS14125 55b0e1a28552e59f2bbdd7a815303fc3 386 Gene3D G3DSA:3.40.50.1820 77 386 4.4E-24 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22400 61ed1dca32af8c38eb3f1f27b2544ab0 114 Gene3D G3DSA:1.10.260.40 9 87 2.5E-13 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS22400 61ed1dca32af8c38eb3f1f27b2544ab0 114 SUPERFAMILY SSF47413 9 68 1.29E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS22400 61ed1dca32af8c38eb3f1f27b2544ab0 114 Pfam PF01381 Helix-turn-helix 10 61 3.0E-9 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS22400 61ed1dca32af8c38eb3f1f27b2544ab0 114 SMART SM00530 9 64 4.5E-8 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 Gene3D G3DSA:3.40.50.1820 655 912 1.1E-45 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 Pfam PF00326 Prolyl oligopeptidase family 745 911 6.6E-22 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 Gene3D G3DSA:2.120.10.30 32 68 8.7E-9 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 Gene3D G3DSA:2.120.10.30 179 317 8.7E-9 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 Gene3D G3DSA:2.120.10.30 338 536 3.7E-5 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 PANTHER PTHR11731 361 922 1.5E-108 T 21-04-2016 SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 PANTHER PTHR11731 241 302 1.5E-108 T 21-04-2016 SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 PANTHER PTHR11731:SF142 361 922 1.5E-108 T 21-04-2016 SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 PANTHER PTHR11731:SF142 241 302 1.5E-108 T 21-04-2016 SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 SUPERFAMILY SSF53474 655 911 1.54E-45 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 SUPERFAMILY SSF82171 383 530 7.72E-12 T 21-04-2016 SPH21_RS15020 d8c838ea095ed4fbce52862c0c8acb67 938 SUPERFAMILY SSF82171 176 346 7.72E-12 T 21-04-2016 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 SMART SM00830 279 359 4.6E-20 T 21-04-2016 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 Pfam PF00793 DAHP synthetase I family 17 252 4.1E-33 T 21-04-2016 IPR006218 DAHP synthetase I/KDSA GO:0009058 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674|UniPathway: UPA00030|UniPathway: UPA00357 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 Gene3D G3DSA:1.20.59.10 265 357 5.6E-19 T 21-04-2016 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 PANTHER PTHR21057:SF7 17 276 9.2E-79 T 21-04-2016 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 Pfam PF01817 Chorismate mutase type II 279 356 1.6E-16 T 21-04-2016 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 PANTHER PTHR21057 17 276 9.2E-79 T 21-04-2016 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 Gene3D G3DSA:3.20.20.70 15 261 6.4E-60 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 SUPERFAMILY SSF51569 15 262 4.12E-59 T 21-04-2016 SPH21_RS16035 f1fdcd31271af7b865eec5968a619eb9 368 SUPERFAMILY SSF48600 272 359 1.83E-20 T 21-04-2016 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS06335 9237993538260fff9f552b1276b88031 303 PANTHER PTHR10907:SF60 66 248 1.5E-15 T 21-04-2016 SPH21_RS06335 9237993538260fff9f552b1276b88031 303 SUPERFAMILY SSF53474 55 301 1.26E-35 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06335 9237993538260fff9f552b1276b88031 303 Gene3D G3DSA:3.40.50.1820 55 301 1.3E-50 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06335 9237993538260fff9f552b1276b88031 303 Pfam PF00756 Putative esterase 59 258 4.9E-16 T 21-04-2016 IPR000801 Putative esterase SPH21_RS06335 9237993538260fff9f552b1276b88031 303 PANTHER PTHR10907 66 248 1.5E-15 T 21-04-2016 SPH21_RS18815 5598df42ab8152985ea358e27f1d0d6b 164 TIGRFAM TIGR00481 TIGR00481: Raf kinase inhibitor-like protein, YbhB/YbcL family 18 141 1.5E-28 T 21-04-2016 IPR005247 YbhB/YbcL SPH21_RS18815 5598df42ab8152985ea358e27f1d0d6b 164 PANTHER PTHR30289 1 142 2.6E-29 T 21-04-2016 SPH21_RS18815 5598df42ab8152985ea358e27f1d0d6b 164 Pfam PF01161 Phosphatidylethanolamine-binding protein 13 142 6.2E-26 T 21-04-2016 IPR008914 Phosphatidylethanolamine-binding protein SPH21_RS18815 5598df42ab8152985ea358e27f1d0d6b 164 Gene3D G3DSA:3.90.280.10 7 143 5.2E-37 T 21-04-2016 IPR008914 Phosphatidylethanolamine-binding protein SPH21_RS18815 5598df42ab8152985ea358e27f1d0d6b 164 SUPERFAMILY SSF49777 5 143 6.02E-35 T 21-04-2016 IPR008914 Phosphatidylethanolamine-binding protein SPH21_RS18060 0d2738354fe82b0970bc55ed1c10edc4 121 PIRSF PIRSF019455 1 121 3.7E-22 T 21-04-2016 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SPH21_RS18060 0d2738354fe82b0970bc55ed1c10edc4 121 PANTHER PTHR34134 1 120 6.3E-30 T 21-04-2016 SPH21_RS18060 0d2738354fe82b0970bc55ed1c10edc4 121 Gene3D G3DSA:1.10.10.10 1 77 1.7E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS18060 0d2738354fe82b0970bc55ed1c10edc4 121 PANTHER PTHR34134:SF1 1 120 6.3E-30 T 21-04-2016 SPH21_RS18060 0d2738354fe82b0970bc55ed1c10edc4 121 SUPERFAMILY SSF46785 1 118 7.27E-27 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS18060 0d2738354fe82b0970bc55ed1c10edc4 121 Pfam PF03965 Penicillinase repressor 4 117 6.1E-27 T 21-04-2016 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SPH21_RS22210 ecc75def5b55c1d089dbb460d244f3e4 159 Pfam PF05163 DinB family 6 157 2.2E-16 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS22210 ecc75def5b55c1d089dbb460d244f3e4 159 Gene3D G3DSA:1.20.120.450 4 158 9.6E-20 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS22210 ecc75def5b55c1d089dbb460d244f3e4 159 SUPERFAMILY SSF109854 7 156 1.41E-14 T 21-04-2016 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 PANTHER PTHR11786 3 252 7.6E-61 T 21-04-2016 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: REACT_13433 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 PRINTS PR01543 Arylamine N-acetyltransferase signature 101 126 1.3E-16 T 21-04-2016 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: REACT_13433 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 PRINTS PR01543 Arylamine N-acetyltransferase signature 68 90 1.3E-16 T 21-04-2016 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: REACT_13433 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 PRINTS PR01543 Arylamine N-acetyltransferase signature 44 67 1.3E-16 T 21-04-2016 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: REACT_13433 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 PRINTS PR01543 Arylamine N-acetyltransferase signature 20 43 1.3E-16 T 21-04-2016 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: REACT_13433 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 Gene3D G3DSA:3.30.2140.10 2 84 1.3E-53 T 21-04-2016 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 Gene3D G3DSA:3.30.2140.10 182 255 1.3E-53 T 21-04-2016 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 Pfam PF00797 N-acetyltransferase 20 252 1.2E-74 T 21-04-2016 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: REACT_13433 SPH21_RS20150 a8fd5dbc680d86648cd76ab9546ecadd 273 SUPERFAMILY SSF54001 2 253 4.51E-80 T 21-04-2016 SPH21_RS08735 e8b9b1ae78d4841565b1eb9c78bb759a 170 Pfam PF13302 Acetyltransferase (GNAT) domain 9 144 1.4E-12 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS08735 e8b9b1ae78d4841565b1eb9c78bb759a 170 PANTHER PTHR23091:SF187 8 153 2.1E-20 T 21-04-2016 SPH21_RS08735 e8b9b1ae78d4841565b1eb9c78bb759a 170 PANTHER PTHR23091 8 153 2.1E-20 T 21-04-2016 SPH21_RS08735 e8b9b1ae78d4841565b1eb9c78bb759a 170 SUPERFAMILY SSF55729 9 168 4.51E-27 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS08735 e8b9b1ae78d4841565b1eb9c78bb759a 170 Gene3D G3DSA:3.40.630.30 10 168 3.9E-32 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS11755 1b4a0d7bb4d27d3812b2016021003acb 635 SUPERFAMILY SSF54001 266 381 8.44E-7 T 21-04-2016 SPH21_RS11755 1b4a0d7bb4d27d3812b2016021003acb 635 Pfam PF12969 Domain of Unknown Function with PDB structure (DUF3857) 58 214 4.7E-23 T 21-04-2016 IPR024618 Domain of unknown function DUF3857 SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SMART SM00564 294 325 1.4E-4 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SMART SM00564 373 405 1.8E-5 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SMART SM00564 334 365 1.8E-4 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SMART SM00564 461 492 5.9 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SMART SM00564 415 446 0.016 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SMART SM00564 548 580 8.7 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 PANTHER PTHR32303 271 578 2.3E-14 T 21-04-2016 SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 Gene3D G3DSA:2.140.10.10 273 609 1.8E-65 T 21-04-2016 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SUPERFAMILY SSF50998 280 525 1.15E-47 T 21-04-2016 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 PANTHER PTHR32303:SF2 271 578 2.3E-14 T 21-04-2016 SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 Pfam PF01011 PQQ enzyme repeat 420 444 2.7E-5 T 21-04-2016 IPR002372 Pyrrolo-quinoline quinone repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 Gene3D G3DSA:3.60.21.10 19 234 1.3E-27 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SUPERFAMILY SSF56300 21 240 1.9E-40 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 Pfam PF13360 PQQ-like domain 280 403 8.4E-18 T 21-04-2016 IPR002372 Pyrrolo-quinoline quinone repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 Pfam PF13360 PQQ-like domain 461 582 4.4E-13 T 21-04-2016 IPR002372 Pyrrolo-quinoline quinone repeat SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 Pfam PF00149 Calcineurin-like phosphoesterase 21 195 1.5E-15 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS16235 ef7aafc7c0f52389fee47f1c457c4089 613 SUPERFAMILY SSF50998 530 610 2.82E-5 T 21-04-2016 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 Gene3D G3DSA:1.20.1250.20 9 195 4.6E-41 T 21-04-2016 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 Gene3D G3DSA:1.20.1250.20 215 397 1.6E-17 T 21-04-2016 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PANTHER PTHR23504 1 401 1.7E-155 T 21-04-2016 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 Pfam PF07690 Major Facilitator Superfamily 278 392 1.5E-11 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 Pfam PF07690 Major Facilitator Superfamily 12 270 8.8E-41 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 SUPERFAMILY SSF103473 6 398 1.83E-66 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 ProSitePatterns PS00216 Sugar transport proteins signature 1. 67 83 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 137 159 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 341 364 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 165 185 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 107 128 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 80 104 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 18 34 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 253 273 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 306 326 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 281 302 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PRINTS PR01035 Tetracycline resistance protein signature 224 241 2.93E-69 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01780 2ea21a583b1771b51c5094e87ec5aeee 402 PANTHER PTHR23504:SF18 1 401 1.7E-155 T 21-04-2016 SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 SUPERFAMILY SSF102114 2 342 8.89E-89 T 21-04-2016 SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 PANTHER PTHR13932 1 352 7.4E-107 T 21-04-2016 SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 PANTHER PTHR13932:SF5 1 352 7.4E-107 T 21-04-2016 SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 Gene3D G3DSA:3.80.30.20 17 205 2.4E-30 T 21-04-2016 IPR023404 Radical SAM, alpha/beta horseshoe SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 TIGRFAM TIGR00539 hemN_rel: putative oxygen-independent coproporphyrinogen III oxidase 3 319 4.6E-72 T 21-04-2016 IPR004559 Coproporphyrinogen III oxidase, oxygen-independent related GO:0004109|GO:0005737|GO:0006779|GO:0055114 KEGG: 00071+1.3.99.-|KEGG: 00280+1.3.99.-|KEGG: 00281+1.3.99.-|KEGG: 00362+1.3.99.-|KEGG: 00626+1.3.99.-|KEGG: 00930+1.3.99.- SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 Pfam PF06969 HemN C-terminal domain 267 330 3.2E-7 T 21-04-2016 IPR010723 HemN, C-terminal SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 SMART SM00729 1 189 2.1E-28 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS05135 2609d4053f19155b26e099d5d7327075 352 Pfam PF04055 Radical SAM superfamily 18 141 3.0E-14 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 Pfam PF07411 Domain of unknown function (DUF1508) 61 107 4.9E-23 T 21-04-2016 IPR010879 Domain of unknown function DUF1508 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 Pfam PF07411 Domain of unknown function (DUF1508) 9 56 9.4E-23 T 21-04-2016 IPR010879 Domain of unknown function DUF1508 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 Gene3D G3DSA:3.30.160.160 2 48 4.7E-23 T 21-04-2016 IPR010879 Domain of unknown function DUF1508 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 Gene3D G3DSA:3.30.160.160 55 99 1.1E-19 T 21-04-2016 IPR010879 Domain of unknown function DUF1508 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 SUPERFAMILY SSF160113 1 58 5.1E-19 T 21-04-2016 IPR010879 Domain of unknown function DUF1508 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 PANTHER PTHR40606 1 104 9.3E-44 T 21-04-2016 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 SUPERFAMILY SSF160113 59 107 1.44E-17 T 21-04-2016 IPR010879 Domain of unknown function DUF1508 SPH21_RS18270 a4f6aa3d4d68531813b9260682b159a0 108 PANTHER PTHR40606:SF1 1 104 9.3E-44 T 21-04-2016 SPH21_RS17205 23f15c8b05e9a53a826a185f21157d96 312 Gene3D G3DSA:3.90.1580.10 24 302 2.8E-65 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS17205 23f15c8b05e9a53a826a185f21157d96 312 PANTHER PTHR23150 13 306 1.2E-57 T 21-04-2016 SPH21_RS17205 23f15c8b05e9a53a826a185f21157d96 312 PANTHER PTHR23150:SF19 13 306 1.2E-57 T 21-04-2016 SPH21_RS17205 23f15c8b05e9a53a826a185f21157d96 312 Pfam PF03781 Sulfatase-modifying factor enzyme 1 35 264 1.5E-46 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS17205 23f15c8b05e9a53a826a185f21157d96 312 SUPERFAMILY SSF56436 31 291 7.53E-57 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS09840 409f2c4a99b1624d91a7eae6af8b999c 761 SUPERFAMILY SSF81296 153 232 3.43E-5 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS09840 409f2c4a99b1624d91a7eae6af8b999c 761 Gene3D G3DSA:2.60.120.260 27 113 3.2E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS09840 409f2c4a99b1624d91a7eae6af8b999c 761 Gene3D G3DSA:2.60.40.10 150 232 4.4E-5 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS08565 2cf24fe766ec2cacfc6dd8b5b778904f 132 Gene3D G3DSA:3.30.1370.30 1 67 4.6E-26 T 21-04-2016 SPH21_RS08565 2cf24fe766ec2cacfc6dd8b5b778904f 132 PANTHER PTHR11758 1 132 4.1E-48 T 21-04-2016 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08565 2cf24fe766ec2cacfc6dd8b5b778904f 132 SUPERFAMILY SSF56047 1 132 5.23E-45 T 21-04-2016 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08565 2cf24fe766ec2cacfc6dd8b5b778904f 132 ProSitePatterns PS00053 Ribosomal protein S8 signature. 102 119 - T 21-04-2016 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08565 2cf24fe766ec2cacfc6dd8b5b778904f 132 Hamap MF_01302_B 30S ribosomal protein S8 [rpsH]. 1 132 30.755 T 21-04-2016 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08565 2cf24fe766ec2cacfc6dd8b5b778904f 132 Pfam PF00410 Ribosomal protein S8 4 132 2.8E-50 T 21-04-2016 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08565 2cf24fe766ec2cacfc6dd8b5b778904f 132 Gene3D G3DSA:3.30.1490.10 76 132 2.7E-29 T 21-04-2016 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 SUPERFAMILY SSF48150 3 218 1.88E-67 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 Gene3D G3DSA:3.90.79.10 227 333 1.0E-6 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 Gene3D G3DSA:1.10.340.30 17 118 3.4E-40 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 SMART SM00478 35 186 1.1E-41 T 21-04-2016 IPR003265 HhH-GPD domain GO:0006284 Reactome: REACT_216 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 32 160 2.5E-15 T 21-04-2016 IPR003265 HhH-GPD domain GO:0006284 Reactome: REACT_216 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 PANTHER PTHR10359:SF1 1 311 8.0E-82 T 21-04-2016 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 SUPERFAMILY SSF55811 228 341 3.85E-6 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 Pfam PF14815 NUDIX domain 231 341 2.4E-11 T 21-04-2016 IPR029119 MutY, C-terminal SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 TIGRFAM TIGR01084 mutY: A/G-specific adenine glycosylase 3 262 1.4E-96 T 21-04-2016 IPR005760 A/G-specific adenine glycosylase MutY GO:0006284|GO:0019104 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 Pfam PF00633 Helix-hairpin-helix motif 96 124 2.4E-6 T 21-04-2016 IPR000445 Helix-hairpin-helix motif GO:0003677 SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 Gene3D G3DSA:1.10.1670.10 119 219 1.1E-36 T 21-04-2016 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal SPH21_RS05555 8319506c3fd099269eb59e3cba9a33ff 352 PANTHER PTHR10359 1 311 8.0E-82 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PANTHER PTHR32063 1 1032 0.0 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82866 834 1029 1.15E-42 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF56954 1038 1071 2.22E-94 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF56954 1095 1524 2.22E-94 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Gene3D G3DSA:1.10.3850.10 282 500 2.5E-60 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Gene3D G3DSA:1.10.3850.10 817 1030 6.9E-53 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PANTHER PTHR32063:SF9 1 1032 0.0 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Pfam PF00873 AcrB/AcrD/AcrF family 1 1029 0.0 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Gene3D G3DSA:3.30.70.1430 38 140 2.9E-29 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82693 275 332 2.2E-20 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82693 135 182 2.2E-20 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 TIGRFAM TIGR01845 outer_NodT: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family 1050 1522 9.9E-81 T 21-04-2016 IPR010131 RND efflux system, outer membrane lipoprotein, NodT GO:0005215|GO:0006810|GO:0008289|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82693 674 724 3.92E-24 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82693 811 860 3.92E-24 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Gene3D G3DSA:1.20.1600.10 1095 1524 6.9E-143 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82693 570 673 3.14E-24 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Gene3D G3DSA:3.30.2090.10 725 810 1.7E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 447 470 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 557 574 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 8 32 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 36 54 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 472 495 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 365 386 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 626 640 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 338 361 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 PRINTS PR00702 Acriflavin resistance protein family signature 393 417 8.7E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Gene3D G3DSA:3.30.2090.10 182 273 2.3E-22 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 1 1040 0.0 T 21-04-2016 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0005215|GO:0006810|GO:0016021 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82693 38 129 2.33E-24 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82714 183 272 1.31E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82714 725 811 1.57E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Pfam PF02321 Outer membrane efflux protein 1104 1307 8.8E-29 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Pfam PF02321 Outer membrane efflux protein 1337 1520 1.3E-19 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 SUPERFAMILY SSF82866 297 500 1.7E-49 T 21-04-2016 SPH21_RS05520 8b9091bfd3adc0a9f5f05b7f6c54fd1d 1524 Gene3D G3DSA:3.30.70.1430 572 673 2.4E-27 T 21-04-2016 SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 Pfam PF00795 Carbon-nitrogen hydrolase 225 478 6.1E-34 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 Gene3D G3DSA:3.40.630.30 2 187 9.4E-16 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 SUPERFAMILY SSF56317 216 483 3.53E-58 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 PANTHER PTHR23088:SF12 203 504 2.5E-137 T 21-04-2016 SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 PANTHER PTHR23088 203 504 2.5E-137 T 21-04-2016 SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 Pfam PF00583 Acetyltransferase (GNAT) family 52 135 1.3E-4 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 ProSitePatterns PS01227 Uncharacterized protein family UPF0012 signature. 366 386 - T 21-04-2016 IPR001110 Uncharacterised protein family UPF0012, conserved site SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 SUPERFAMILY SSF55729 1 135 2.34E-12 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12215 841e97c114b709f27db2846a0fbfea54 504 Gene3D G3DSA:3.60.110.10 212 500 2.7E-61 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS19615 be94f13590be08414105bbc3d97f1370 175 PANTHER PTHR28026:SF3 8 173 1.7E-37 T 21-04-2016 SPH21_RS19615 be94f13590be08414105bbc3d97f1370 175 PANTHER PTHR28026 8 173 1.7E-37 T 21-04-2016 SPH21_RS19615 be94f13590be08414105bbc3d97f1370 175 Pfam PF06127 Protein of unknown function (DUF962) 21 170 8.0E-23 T 21-04-2016 IPR009305 Protein of unknown function DUF962 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 Hamap MF_00089 Phosphomethylpyrimidine synthase [thiC]. 134 591 56.407 T 21-04-2016 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890|UniPathway: UPA00060 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 Pfam PF01964 Radical SAM ThiC family 136 585 5.0E-202 T 21-04-2016 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890|UniPathway: UPA00060 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 PANTHER PTHR30557 127 157 0.0 T 21-04-2016 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 PANTHER PTHR30557 11 93 0.0 T 21-04-2016 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 PANTHER PTHR30557 188 621 0.0 T 21-04-2016 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 Pfam PF13667 ThiC-associated domain 16 94 4.4E-33 T 21-04-2016 IPR025747 ThiC-associated domain KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890|UniPathway: UPA00060 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 PANTHER PTHR30557:SF1 127 157 0.0 T 21-04-2016 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 PANTHER PTHR30557:SF1 11 93 0.0 T 21-04-2016 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 PANTHER PTHR30557:SF1 188 621 0.0 T 21-04-2016 SPH21_RS06830 ce9a0b0ae48f3e8f471525bd9181b141 622 TIGRFAM TIGR00190 thiC: phosphomethylpyrimidine synthase 134 588 4.7E-219 T 21-04-2016 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890|UniPathway: UPA00060 SPH21_RS00795 491b850faa09dec8296fe929f9500279 515 Pfam PF13007 Transposase C of IS166 homeodomain 48 120 1.7E-13 T 21-04-2016 IPR024463 Transposase TnpC, homeodomain SPH21_RS00795 491b850faa09dec8296fe929f9500279 515 Pfam PF13005 zinc-finger binding domain of transposase IS66 130 160 1.4E-6 T 21-04-2016 IPR024474 Zinc-finger binding domain of transposase IS66 SPH21_RS00795 491b850faa09dec8296fe929f9500279 515 PANTHER PTHR33678:SF1 14 503 7.4E-113 T 21-04-2016 SPH21_RS00795 491b850faa09dec8296fe929f9500279 515 Pfam PF03050 Transposase IS66 family 180 460 1.2E-93 T 21-04-2016 IPR004291 Transposase, IS66 SPH21_RS00795 491b850faa09dec8296fe929f9500279 515 PANTHER PTHR33678 14 503 7.4E-113 T 21-04-2016 SPH21_RS24310 491b850faa09dec8296fe929f9500279 515 Pfam PF13007 Transposase C of IS166 homeodomain 48 120 1.7E-13 T 21-04-2016 IPR024463 Transposase TnpC, homeodomain SPH21_RS24310 491b850faa09dec8296fe929f9500279 515 Pfam PF13005 zinc-finger binding domain of transposase IS66 130 160 1.4E-6 T 21-04-2016 IPR024474 Zinc-finger binding domain of transposase IS66 SPH21_RS24310 491b850faa09dec8296fe929f9500279 515 PANTHER PTHR33678:SF1 14 503 7.4E-113 T 21-04-2016 SPH21_RS24310 491b850faa09dec8296fe929f9500279 515 Pfam PF03050 Transposase IS66 family 180 460 1.2E-93 T 21-04-2016 IPR004291 Transposase, IS66 SPH21_RS24310 491b850faa09dec8296fe929f9500279 515 PANTHER PTHR33678 14 503 7.4E-113 T 21-04-2016 SPH21_RS24975 491b850faa09dec8296fe929f9500279 515 Pfam PF13007 Transposase C of IS166 homeodomain 48 120 1.7E-13 T 21-04-2016 IPR024463 Transposase TnpC, homeodomain SPH21_RS24975 491b850faa09dec8296fe929f9500279 515 Pfam PF13005 zinc-finger binding domain of transposase IS66 130 160 1.4E-6 T 21-04-2016 IPR024474 Zinc-finger binding domain of transposase IS66 SPH21_RS24975 491b850faa09dec8296fe929f9500279 515 PANTHER PTHR33678:SF1 14 503 7.4E-113 T 21-04-2016 SPH21_RS24975 491b850faa09dec8296fe929f9500279 515 Pfam PF03050 Transposase IS66 family 180 460 1.2E-93 T 21-04-2016 IPR004291 Transposase, IS66 SPH21_RS24975 491b850faa09dec8296fe929f9500279 515 PANTHER PTHR33678 14 503 7.4E-113 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 SUPERFAMILY SSF52374 205 282 1.09E-117 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 SUPERFAMILY SSF52374 3 146 1.09E-117 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 SUPERFAMILY SSF52374 470 748 1.09E-117 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 697 726 7.8E-6 T 21-04-2016 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PRINTS PR00985 Leucyl-tRNA synthetase signature 609 619 6.6E-41 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PRINTS PR00985 Leucyl-tRNA synthetase signature 576 598 6.6E-41 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PRINTS PR00985 Leucyl-tRNA synthetase signature 271 290 6.6E-41 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PRINTS PR00985 Leucyl-tRNA synthetase signature 126 143 6.6E-41 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PRINTS PR00985 Leucyl-tRNA synthetase signature 242 255 6.6E-41 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PRINTS PR00985 Leucyl-tRNA synthetase signature 537 555 6.6E-41 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946 696 927 0.0 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946 344 623 0.0 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946 296 321 0.0 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946 1 146 0.0 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946 205 263 0.0 T 21-04-2016 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946:SF7 696 927 0.0 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946:SF7 344 623 0.0 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946:SF7 296 321 0.0 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946:SF7 1 146 0.0 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 PANTHER PTHR11946:SF7 205 263 0.0 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 SUPERFAMILY SSF47323 742 927 4.86E-31 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Pfam PF13603 Leucyl-tRNA synthetase, Domain 2 277 457 8.3E-61 T 21-04-2016 IPR025709 Leucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 42 52 - T 21-04-2016 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 SUPERFAMILY SSF50677 282 469 1.7E-49 T 21-04-2016 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Hamap MF_00049_B Leucine--tRNA ligase [leuS]. 2 927 21.503 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Gene3D G3DSA:3.90.740.10 279 478 1.0E-54 T 21-04-2016 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Pfam PF09334 tRNA synthetases class I (M) 38 144 6.7E-15 T 21-04-2016 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Pfam PF08264 Anticodon-binding domain of tRNA 777 889 2.5E-13 T 21-04-2016 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Gene3D G3DSA:1.10.730.10 729 863 3.4E-35 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 TIGRFAM TIGR00396 leuS_bact: leucine--tRNA ligase 197 927 1.0E-220 T 21-04-2016 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4 SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Gene3D G3DSA:3.40.50.620 479 626 9.1E-150 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Gene3D G3DSA:3.40.50.620 204 278 9.1E-150 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Gene3D G3DSA:3.40.50.620 699 728 9.1E-150 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS02690 27d740c897a0ed5e1e68d82a22c2d905 927 Gene3D G3DSA:3.40.50.620 1 145 9.1E-150 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS23610 33ab9d7399858b118e5e9f4d3963edb0 304 PANTHER PTHR11019 27 303 2.8E-35 T 21-04-2016 SPH21_RS23610 33ab9d7399858b118e5e9f4d3963edb0 304 Gene3D G3DSA:1.10.10.60 255 302 2.0E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23610 33ab9d7399858b118e5e9f4d3963edb0 304 SUPERFAMILY SSF46689 255 303 2.6E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23610 33ab9d7399858b118e5e9f4d3963edb0 304 SUPERFAMILY SSF51215 24 176 1.57E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS23610 33ab9d7399858b118e5e9f4d3963edb0 304 PANTHER PTHR11019:SF50 27 303 2.8E-35 T 21-04-2016 SPH21_RS23610 33ab9d7399858b118e5e9f4d3963edb0 304 Pfam PF12833 Helix-turn-helix domain 223 301 8.0E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23610 33ab9d7399858b118e5e9f4d3963edb0 304 SMART SM00342 217 300 6.7E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 SMART SM00420 7 59 3.6E-13 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 Gene3D G3DSA:3.40.50.1360 78 216 1.9E-12 T 21-04-2016 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 SMART SM01134 74 235 1.3E-56 T 21-04-2016 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 Pfam PF00455 DeoR C terminal sensor domain 76 234 1.2E-46 T 21-04-2016 IPR014036 DeoR C-terminal sensor domain SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 SUPERFAMILY SSF46785 4 73 7.68E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 SUPERFAMILY SSF100950 76 235 3.98E-27 T 21-04-2016 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 PANTHER PTHR30363:SF1 1 254 3.6E-72 T 21-04-2016 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 Pfam PF08220 DeoR-like helix-turn-helix domain 7 60 2.0E-13 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 PANTHER PTHR30363 1 254 3.6E-72 T 21-04-2016 SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 Gene3D G3DSA:1.10.10.10 3 59 3.1E-7 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02115 1f367fa2cfada7dfd4e3a6402dda5c12 255 ProSitePatterns PS00894 DeoR-type HTH domain signature. 7 41 - T 21-04-2016 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 SUPERFAMILY SSF49464 123 216 6.28E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 Pfam PF07715 TonB-dependent Receptor Plug Domain 218 351 9.7E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 Pfam PF13715 CarboxypepD_reg-like domain 125 208 4.3E-14 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 122 1160 3.4E-159 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532:SF51 318 505 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532:SF51 551 602 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532:SF51 650 1158 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532:SF51 107 291 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 327 357 5.9E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532 318 505 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532 551 602 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532 650 1158 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 PANTHER PTHR11532 107 291 1.9E-151 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 Gene3D G3DSA:2.170.130.10 210 354 3.9E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 Gene3D G3DSA:2.40.170.20 458 918 7.6E-28 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 Gene3D G3DSA:2.40.170.20 963 995 7.6E-28 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 Gene3D G3DSA:2.60.40.1120 123 209 2.1E-17 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 SUPERFAMILY SSF56935 451 539 1.42E-67 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 SUPERFAMILY SSF56935 580 918 1.42E-67 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 SUPERFAMILY SSF56935 1067 1160 1.42E-67 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 SUPERFAMILY SSF56935 205 377 1.42E-67 T 21-04-2016 SPH21_RS12385 8608fb7be6a0147f8a6c9eb2161338f6 1160 SUPERFAMILY SSF56935 974 1017 1.42E-67 T 21-04-2016 SPH21_RS15305 8bbb8a3798eaab685c2e2d32e628e0d6 138 SUPERFAMILY SSF54637 7 136 3.89E-31 T 21-04-2016 IPR029069 HotDog domain SPH21_RS15305 8bbb8a3798eaab685c2e2d32e628e0d6 138 Pfam PF13279 Thioesterase-like superfamily 14 135 6.9E-14 T 21-04-2016 SPH21_RS15305 8bbb8a3798eaab685c2e2d32e628e0d6 138 Gene3D G3DSA:3.10.129.10 7 136 2.6E-30 T 21-04-2016 IPR029069 HotDog domain SPH21_RS15305 8bbb8a3798eaab685c2e2d32e628e0d6 138 PANTHER PTHR31793 7 135 3.8E-26 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 Gene3D G3DSA:3.30.70.260 659 728 3.7E-13 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 PANTHER PTHR21262:SF0 7 735 0.0 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 Pfam PF13291 ACT domain 657 732 2.9E-19 T 21-04-2016 IPR002912 ACT domain GO:0008152|GO:0016597 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 TIGRFAM TIGR00691 spoT_relA: RelA/SpoT family protein 41 730 9.0E-200 T 21-04-2016 IPR004811 RelA/SpoT family GO:0015969 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 SUPERFAMILY SSF81301 196 408 1.06E-55 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 SMART SM00954 250 365 3.1E-54 T 21-04-2016 IPR007685 RelA/SpoT GO:0015969 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 SMART SM00471 56 168 2.3E-10 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 Gene3D G3DSA:3.30.460.10 192 344 5.5E-45 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 SUPERFAMILY SSF81271 391 464 8.28E-21 T 21-04-2016 IPR012676 TGS-like KEGG: 00970+6.1.1.3 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 Pfam PF13328 HD domain 41 190 4.0E-44 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 SUPERFAMILY SSF55021 660 732 9.16E-9 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 SUPERFAMILY SSF109604 19 205 6.59E-63 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 Pfam PF02824 TGS domain 404 463 4.7E-20 T 21-04-2016 IPR004095 TGS KEGG: 00970+6.1.1.3 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 PANTHER PTHR21262 7 735 0.0 T 21-04-2016 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 Pfam PF04607 Region found in RelA / SpoT proteins 250 365 7.2E-34 T 21-04-2016 IPR007685 RelA/SpoT GO:0015969 SPH21_RS14910 b232dc322d6a41bb1047fa3ea812cdf7 737 Gene3D G3DSA:3.10.20.30 403 465 6.6E-23 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS10260 41f9e2af971ba1c98f2a827d7f290ef5 315 SUPERFAMILY SSF75005 12 308 4.28E-73 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS10260 41f9e2af971ba1c98f2a827d7f290ef5 315 PANTHER PTHR22925 24 314 3.2E-109 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS10260 41f9e2af971ba1c98f2a827d7f290ef5 315 Pfam PF04616 Glycosyl hydrolases family 43 27 307 1.5E-51 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS10260 41f9e2af971ba1c98f2a827d7f290ef5 315 Gene3D G3DSA:2.115.10.20 17 308 9.3E-80 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS10260 41f9e2af971ba1c98f2a827d7f290ef5 315 PANTHER PTHR22925:SF42 24 314 3.2E-109 T 21-04-2016 SPH21_RS07810 c7a33dfce769529a3e690b6bb3df4154 291 TIGRFAM TIGR00147 TIGR00147: lipid kinase, YegS/Rv2252/BmrU family 4 290 1.6E-50 T 21-04-2016 IPR005218 Diacylglycerol/lipid kinase SPH21_RS07810 c7a33dfce769529a3e690b6bb3df4154 291 Pfam PF00781 Diacylglycerol kinase catalytic domain 7 125 3.5E-28 T 21-04-2016 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SPH21_RS07810 c7a33dfce769529a3e690b6bb3df4154 291 SMART SM00046 5 130 1.0E-7 T 21-04-2016 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SPH21_RS07810 c7a33dfce769529a3e690b6bb3df4154 291 Gene3D G3DSA:3.40.50.10330 31 99 2.5E-7 T 21-04-2016 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS07810 c7a33dfce769529a3e690b6bb3df4154 291 PANTHER PTHR12358 4 291 3.0E-59 T 21-04-2016 SPH21_RS07810 c7a33dfce769529a3e690b6bb3df4154 291 SUPERFAMILY SSF111331 4 291 8.76E-75 T 21-04-2016 IPR016064 NAD kinase/diacylglycerol kinase-like domain SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 SUPERFAMILY SSF46689 28 78 1.88E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 PANTHER PTHR11019 26 134 3.5E-26 T 21-04-2016 SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 81 122 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 Gene3D G3DSA:1.10.10.60 82 127 9.5E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 SMART SM00342 44 126 6.3E-30 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 SUPERFAMILY SSF46689 80 127 3.54E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 Gene3D G3DSA:1.10.10.60 23 81 3.2E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04500 04d5b23318ec9ff51c68aeed36d25a9d 134 Pfam PF12833 Helix-turn-helix domain 50 126 5.9E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 Pfam PF02769 AIR synthase related protein, C-terminal domain 381 534 2.3E-21 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 Pfam PF02769 AIR synthase related protein, C-terminal domain 779 900 1.8E-10 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 Pfam PF13507 CobB/CobQ-like glutamine amidotransferase domain 972 1216 6.3E-80 T 21-04-2016 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SUPERFAMILY SSF56042 379 600 4.78E-39 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SMART SM01211 972 1216 1.2E-105 T 21-04-2016 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SUPERFAMILY SSF55326 564 756 1.15E-51 T 21-04-2016 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SUPERFAMILY SSF52317 971 1216 1.58E-74 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 Gene3D G3DSA:3.40.50.880 973 1212 1.3E-6 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 PANTHER PTHR10099:SF1 18 1219 0.0 T 21-04-2016 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SUPERFAMILY SSF82697 12 105 4.18E-15 T 21-04-2016 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 Gene3D G3DSA:3.30.1330.10 162 367 3.9E-32 T 21-04-2016 IPR016188 PurM-like, N-terminal domain SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 Gene3D G3DSA:3.30.1330.10 592 748 1.1E-12 T 21-04-2016 IPR016188 PurM-like, N-terminal domain SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SUPERFAMILY SSF56042 761 947 1.35E-34 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 PANTHER PTHR10099 18 1219 0.0 T 21-04-2016 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SUPERFAMILY SSF55326 172 371 1.15E-42 T 21-04-2016 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 Hamap MF_00419 Phosphoribosylformylglycinamidine synthase [purL]. 1 1217 18.901 T 21-04-2016 IPR010073 Phosphoribosylformylglycinamidine synthase GO:0004642|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS19160 345f79ca15708d0ea11a53079aee4493 1219 SUPERFAMILY SSF109736 119 171 9.81E-13 T 21-04-2016 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 TIGRFAM TIGR02482 PFKA_ATP: 6-phosphofructokinase 7 306 2.6E-123 T 21-04-2016 IPR012828 ATP-dependent 6-phosphofructokinase, prokaryotic GO:0003872|GO:0005524|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 Pfam PF00365 Phosphofructokinase 6 281 1.5E-104 T 21-04-2016 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 ProSitePatterns PS00433 Phosphofructokinase signature. 249 267 - T 21-04-2016 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 SUPERFAMILY SSF53784 2 315 5.36E-112 T 21-04-2016 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PANTHER PTHR13697:SF4 4 307 4.3E-128 T 21-04-2016 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PIRSF PIRSF000532 3 322 7.1E-114 T 21-04-2016 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PANTHER PTHR13697 4 307 4.3E-128 T 21-04-2016 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 162 178 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 96 112 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 245 267 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 9 28 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 34 47 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 124 141 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 215 227 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 142 160 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 180 197 6.7E-79 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 Gene3D G3DSA:3.40.50.450 2 216 3.9E-73 T 21-04-2016 SPH21_RS05215 3d8d195cb1582dbe78c4c829e6edf108 324 Hamap MF_00339 ATP-dependent 6-phosphofructokinase [pfkA]. 4 324 44.143 T 21-04-2016 IPR012828 ATP-dependent 6-phosphofructokinase, prokaryotic GO:0003872|GO:0005524|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 Pfam PF08760 Domain of unknown function (DUF1793) 661 824 4.7E-59 T 21-04-2016 IPR014870 Domain of unknown function DUF1793 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 SUPERFAMILY SSF49785 118 237 6.8E-9 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 SUPERFAMILY SSF48208 533 719 1.47E-7 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 PANTHER PTHR31987:SF1 244 829 3.9E-233 T 21-04-2016 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 PANTHER PTHR31987:SF1 7 96 3.9E-233 T 21-04-2016 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 Gene3D G3DSA:2.60.120.260 119 231 6.9E-8 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 Pfam PF16334 Domain of unknown function (DUF4964) 16 100 1.4E-32 T 21-04-2016 IPR032515 Domain of unknown function DUF4964 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 Pfam PF16335 Domain of unknown function (DUF4965) 487 655 9.8E-71 T 21-04-2016 IPR032514 Domain of unknown function DUF4965 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 PANTHER PTHR31987 244 829 3.9E-233 T 21-04-2016 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 PANTHER PTHR31987 7 96 3.9E-233 T 21-04-2016 SPH21_RS02975 7f7fa806b811adf54022941159df9372 832 Pfam PF17168 Domain of unknown function (DUF5127) 259 482 6.1E-54 T 21-04-2016 IPR033433 Domain of unknown function DUF5127 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 Pfam PF14905 Outer membrane protein beta-barrel family 381 797 7.6E-107 T 21-04-2016 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 Gene3D G3DSA:2.40.170.20 231 799 1.2E-47 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 Pfam PF13620 Carboxypeptidase regulatory-like domain 30 112 1.0E-16 T 21-04-2016 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 PANTHER PTHR30069 431 679 1.1E-12 T 21-04-2016 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 PANTHER PTHR30069 28 351 1.1E-12 T 21-04-2016 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 PANTHER PTHR30069:SF2 431 679 1.1E-12 T 21-04-2016 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 PANTHER PTHR30069:SF2 28 351 1.1E-12 T 21-04-2016 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 Gene3D G3DSA:2.170.130.10 143 230 8.5E-11 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 Pfam PF07715 TonB-dependent Receptor Plug Domain 149 229 9.0E-7 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 SUPERFAMILY SSF56935 122 799 2.2E-72 T 21-04-2016 SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 Gene3D G3DSA:2.60.40.1120 30 130 4.6E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS07420 7efe9129615ffe4b2b6907bea7846b97 826 SUPERFAMILY SSF49464 29 131 7.06E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 SUPERFAMILY SSF81340 13 446 6.8E-81 T 21-04-2016 IPR014743 Chloride channel, core GO:0005216|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 Gene3D G3DSA:1.10.3080.10 14 454 5.2E-71 T 21-04-2016 IPR014743 Chloride channel, core GO:0005216|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 PANTHER PTHR11689 7 589 9.5E-70 T 21-04-2016 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 PRINTS PR00762 Chloride channel signature 117 136 5.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 PRINTS PR00762 Chloride channel signature 380 396 5.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 PRINTS PR00762 Chloride channel signature 398 417 5.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 PRINTS PR00762 Chloride channel signature 346 366 5.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 PRINTS PR00762 Chloride channel signature 168 187 5.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 Pfam PF00571 CBS domain 538 580 5.1E-4 T 21-04-2016 IPR000644 CBS domain SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 Gene3D G3DSA:3.10.580.10 460 580 1.0E-20 T 21-04-2016 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 Pfam PF00654 Voltage gated chloride channel 74 430 1.9E-72 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 PANTHER PTHR11689:SF14 7 589 9.5E-70 T 21-04-2016 SPH21_RS15040 c26a308ef9f40f1c6a8ee9d46474b412 594 SUPERFAMILY SSF54631 462 582 1.71E-17 T 21-04-2016 SPH21_RS26210 256a3fe15a226132ec4e0e20e5eb8f2a 439 Pfam PF13439 Glycosyltransferase Family 4 48 240 1.4E-18 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS26210 256a3fe15a226132ec4e0e20e5eb8f2a 439 PANTHER PTHR12526 29 426 6.7E-38 T 21-04-2016 SPH21_RS26210 256a3fe15a226132ec4e0e20e5eb8f2a 439 Pfam PF13692 Glycosyl transferases group 1 255 383 6.9E-17 T 21-04-2016 SPH21_RS26210 256a3fe15a226132ec4e0e20e5eb8f2a 439 Gene3D G3DSA:3.40.50.2000 252 394 1.3E-16 T 21-04-2016 SPH21_RS26210 256a3fe15a226132ec4e0e20e5eb8f2a 439 SUPERFAMILY SSF53756 34 426 3.81E-60 T 21-04-2016 SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 1.0E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 1.0E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 Gene3D G3DSA:1.10.357.10 2 186 8.8E-36 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 Pfam PF16925 Bacterial transcriptional repressor C-terminal 80 176 9.5E-10 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 SUPERFAMILY SSF48498 79 192 4.45E-15 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 ProSitePatterns PS01081 TetR-type HTH domain signature. 23 53 - T 21-04-2016 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 PANTHER PTHR30055 4 168 1.1E-25 T 21-04-2016 SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 55 1.6E-13 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS12135 3a907d88d66ded67034ea62ececc1163 196 SUPERFAMILY SSF46689 2 63 1.08E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Pfam PF07715 TonB-dependent Receptor Plug Domain 228 334 1.9E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Gene3D G3DSA:2.40.170.20 1041 1137 1.2E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Gene3D G3DSA:2.40.170.20 425 901 1.2E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Gene3D G3DSA:2.40.170.20 979 1004 1.2E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Gene3D G3DSA:2.40.170.20 339 355 1.2E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 136 1137 8.7E-285 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Pfam PF07660 Secretin and TonB N terminus short domain 70 119 4.5E-8 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Pfam PF13715 CarboxypepD_reg-like domain 137 220 5.4E-15 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 PANTHER PTHR11532 673 1135 8.6E-262 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 PANTHER PTHR11532 131 472 8.6E-262 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 PANTHER PTHR11532 583 643 8.6E-262 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 SUPERFAMILY SSF49464 136 230 1.44E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Gene3D G3DSA:2.60.40.1120 137 228 2.6E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 310 340 2.0E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 PANTHER PTHR11532:SF57 673 1135 8.6E-262 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 PANTHER PTHR11532:SF57 131 472 8.6E-262 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 PANTHER PTHR11532:SF57 583 643 8.6E-262 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 SMART SM00965 70 120 4.6E-10 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 SUPERFAMILY SSF56935 970 1014 6.87E-93 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 SUPERFAMILY SSF56935 216 359 6.87E-93 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 SUPERFAMILY SSF56935 1051 1137 6.87E-93 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 SUPERFAMILY SSF56935 536 892 6.87E-93 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 SUPERFAMILY SSF56935 416 506 6.87E-93 T 21-04-2016 SPH21_RS14670 13b1d84c965fafd3cae3067a6de348be 1138 Gene3D G3DSA:2.170.130.10 229 338 7.1E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 PANTHER PTHR26402 2 223 3.4E-61 T 21-04-2016 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 Pfam PF00072 Response regulator receiver domain 5 113 1.8E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 SMART SM00448 2 113 8.6E-35 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 Gene3D G3DSA:3.40.50.2300 4 124 5.2E-35 T 21-04-2016 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 222 1.5E-17 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 SMART SM00862 148 222 1.5E-16 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 Gene3D G3DSA:1.10.10.10 125 222 1.3E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 SUPERFAMILY SSF46894 125 223 4.54E-20 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 PANTHER PTHR26402:SF292 2 223 3.4E-61 T 21-04-2016 SPH21_RS17030 e25962c282dc7976bc975e5e33d691a2 224 SUPERFAMILY SSF52172 2 128 1.07E-35 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 TIGRFAM TIGR00191 thrB: homoserine kinase 20 317 4.1E-70 T 21-04-2016 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702|UniPathway: UPA00050 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PANTHER PTHR20861:SF1 2 314 1.6E-87 T 21-04-2016 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 Pfam PF08544 GHMP kinases C terminal 234 299 5.1E-11 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 SUPERFAMILY SSF54211 20 180 8.35E-33 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 Hamap MF_00384 Homoserine kinase [thrB]. 20 324 30.042 T 21-04-2016 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702|UniPathway: UPA00050 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 ProSitePatterns PS00627 GHMP kinases putative ATP-binding domain. 106 117 - T 21-04-2016 IPR006203 GHMP kinase, ATP-binding, conserved site GO:0005524 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PIRSF PIRSF000676 17 325 1.4E-81 T 21-04-2016 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702|UniPathway: UPA00050 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 SUPERFAMILY SSF55060 187 302 3.96E-25 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 Pfam PF00288 GHMP kinases N terminal domain 100 166 3.0E-16 T 21-04-2016 IPR006204 GHMP kinase N-terminal domain GO:0005524 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PANTHER PTHR20861 2 314 1.6E-87 T 21-04-2016 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PRINTS PR00958 Homoserine kinase signature 27 42 6.1E-27 T 21-04-2016 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PRINTS PR00958 Homoserine kinase signature 270 285 6.1E-27 T 21-04-2016 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PRINTS PR00958 Homoserine kinase signature 153 166 6.1E-27 T 21-04-2016 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PRINTS PR00958 Homoserine kinase signature 113 128 6.1E-27 T 21-04-2016 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 PRINTS PR00958 Homoserine kinase signature 191 208 6.1E-27 T 21-04-2016 SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 Gene3D G3DSA:3.30.70.890 183 312 4.7E-32 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS07035 715cc7aaf9aa183071c75bd7347c133c 325 Gene3D G3DSA:3.30.230.10 19 179 7.4E-49 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS18015 3b0209613e3daa587b3341984bb40793 186 SUPERFAMILY SSF88946 8 115 7.85E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS18015 3b0209613e3daa587b3341984bb40793 186 PANTHER PTHR30173 1 183 5.7E-18 T 21-04-2016 SPH21_RS18015 3b0209613e3daa587b3341984bb40793 186 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 27 182 2.0E-18 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS18015 3b0209613e3daa587b3341984bb40793 186 Gene3D G3DSA:1.10.1740.10 8 120 3.0E-14 T 21-04-2016 SPH21_RS18015 3b0209613e3daa587b3341984bb40793 186 Gene3D G3DSA:1.10.10.10 122 183 7.8E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS18015 3b0209613e3daa587b3341984bb40793 186 Pfam PF04542 Sigma-70 region 2 30 97 2.3E-4 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS18015 3b0209613e3daa587b3341984bb40793 186 SUPERFAMILY SSF88659 121 182 1.31E-6 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 PANTHER PTHR12143:SF22 418 760 7.3E-192 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 PANTHER PTHR12143:SF22 263 402 7.3E-192 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 PANTHER PTHR12143:SF22 2 246 7.3E-192 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 Pfam PF07971 Glycosyl hydrolase family 92 270 758 2.8E-164 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 SUPERFAMILY SSF48208 291 739 5.27E-29 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 22 760 6.4E-192 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 PANTHER PTHR12143 418 760 7.3E-192 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 PANTHER PTHR12143 263 402 7.3E-192 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 PANTHER PTHR12143 2 246 7.3E-192 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 Gene3D G3DSA:1.20.1610.10 471 623 2.8E-58 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 Gene3D G3DSA:2.70.98.10 23 354 6.4E-101 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 Gene3D G3DSA:1.20.1050.60 378 470 9.4E-29 T 21-04-2016 SPH21_RS10155 b28a56e9d53e74193d41f60b09d0c3e3 761 Gene3D G3DSA:3.30.2080.10 624 760 7.6E-57 T 21-04-2016 SPH21_RS19130 e7242db7a88b13d9782b1047c2641a40 405 SUPERFAMILY SSF103473 13 402 1.96E-61 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS19130 e7242db7a88b13d9782b1047c2641a40 405 PANTHER PTHR23505:SF8 1 404 3.6E-146 T 21-04-2016 SPH21_RS19130 e7242db7a88b13d9782b1047c2641a40 405 Gene3D G3DSA:1.20.1250.20 21 189 7.6E-23 T 21-04-2016 SPH21_RS19130 e7242db7a88b13d9782b1047c2641a40 405 Gene3D G3DSA:1.20.1250.20 224 401 3.7E-25 T 21-04-2016 SPH21_RS19130 e7242db7a88b13d9782b1047c2641a40 405 Pfam PF07690 Major Facilitator Superfamily 25 260 2.2E-27 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS19130 e7242db7a88b13d9782b1047c2641a40 405 PANTHER PTHR23505 1 404 3.6E-146 T 21-04-2016 SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 Pfam PF00675 Insulinase (Peptidase family M16) 34 173 1.2E-23 T 21-04-2016 IPR011765 Peptidase M16, N-terminal SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 PANTHER PTHR11851:SF136 17 436 8.5E-125 T 21-04-2016 SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 Gene3D G3DSA:3.30.830.10 21 240 3.9E-59 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 SUPERFAMILY SSF63411 20 232 2.57E-58 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 PANTHER PTHR11851 17 436 8.5E-125 T 21-04-2016 SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 SUPERFAMILY SSF63411 254 435 6.38E-34 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 Gene3D G3DSA:3.30.830.10 257 430 7.1E-23 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS02565 7be3989de40f9d2ca9a025db672e3747 438 Pfam PF05193 Peptidase M16 inactive domain 189 365 2.8E-26 T 21-04-2016 IPR007863 Peptidase M16, C-terminal SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 SMART SM00387 525 622 1.4E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 Pfam PF07730 Histidine kinase 422 486 4.6E-11 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 527 621 3.3E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 PANTHER PTHR24421:SF23 417 629 2.0E-41 T 21-04-2016 SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 Gene3D G3DSA:3.30.565.10 523 623 6.3E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 Gene3D G3DSA:3.30.565.10 455 483 6.3E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 PANTHER PTHR24421:SF23 62 359 2.0E-41 T 21-04-2016 SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 Pfam PF13675 Type IV pili methyl-accepting chemotaxis transducer N-term 59 124 2.0E-10 T 21-04-2016 IPR029095 NarX-like, N-terminal SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 SUPERFAMILY SSF55874 521 620 3.41E-18 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 SUPERFAMILY SSF55785 284 388 4.0E-8 T 21-04-2016 IPR000014 PAS domain SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 PANTHER PTHR24421 62 359 2.0E-41 T 21-04-2016 SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 PANTHER PTHR24421 417 629 2.0E-41 T 21-04-2016 SPH21_RS18650 c269fb2fdff116eeffc2e85cff7c8032 629 Gene3D G3DSA:3.30.450.20 289 384 2.8E-5 T 21-04-2016 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 Gene3D G3DSA:3.40.50.300 236 516 5.7E-102 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 SMART SM00357 156 222 1.7E-18 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 TIGRFAM TIGR00767 rho: transcription termination factor Rho 2 518 9.0E-197 T 21-04-2016 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 260 464 1.9E-24 T 21-04-2016 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 SMART SM00959 5 47 3.5E-6 T 21-04-2016 IPR011112 Rho termination factor, N-terminal GO:0006353 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 PANTHER PTHR15184 80 518 5.4E-184 T 21-04-2016 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 Gene3D G3DSA:2.40.50.140 1 45 2.9E-49 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 Gene3D G3DSA:2.40.50.140 150 228 2.9E-49 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 Pfam PF07498 Rho termination factor, N-terminal domain 5 44 1.8E-8 T 21-04-2016 IPR011112 Rho termination factor, N-terminal GO:0006353 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 SUPERFAMILY SSF50249 153 228 1.43E-26 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 PANTHER PTHR15184:SF34 80 518 5.4E-184 T 21-04-2016 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 SMART SM00382 271 456 3.1E-7 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 Pfam PF07497 Rho termination factor, RNA-binding domain 156 228 4.8E-32 T 21-04-2016 IPR011113 Rho termination factor, RNA-binding GO:0003723|GO:0006353 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 SUPERFAMILY SSF52540 194 471 3.4E-68 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 Hamap MF_01884 Transcription termination factor Rho [rho]. 153 519 205.493 T 21-04-2016 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 SPH21_RS19945 c4d4be76d1a239b56936019564a156d9 519 SUPERFAMILY SSF68912 1 42 3.14E-7 T 21-04-2016 IPR011112 Rho termination factor, N-terminal GO:0006353 SPH21_RS22270 7069a7b7750e204ed87a25b8d737d085 522 PANTHER PTHR34219:SF3 1 396 7.8E-42 T 21-04-2016 SPH21_RS22270 7069a7b7750e204ed87a25b8d737d085 522 Pfam PF03929 PepSY-associated TM region 11 383 1.6E-51 T 21-04-2016 IPR005625 PepSY-associated TM protein SPH21_RS22270 7069a7b7750e204ed87a25b8d737d085 522 PANTHER PTHR34219 1 396 7.8E-42 T 21-04-2016 SPH21_RS06060 e7f3f3a5f5d591920da2ec810daac240 441 PANTHER PTHR30026:SF4 6 440 7.2E-46 T 21-04-2016 SPH21_RS06060 e7f3f3a5f5d591920da2ec810daac240 441 Pfam PF02321 Outer membrane efflux protein 31 221 3.7E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS06060 e7f3f3a5f5d591920da2ec810daac240 441 Pfam PF02321 Outer membrane efflux protein 249 429 8.8E-29 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS06060 e7f3f3a5f5d591920da2ec810daac240 441 SUPERFAMILY SSF56954 5 431 5.89E-65 T 21-04-2016 SPH21_RS06060 e7f3f3a5f5d591920da2ec810daac240 441 Gene3D G3DSA:1.20.1600.10 29 439 1.6E-60 T 21-04-2016 SPH21_RS06060 e7f3f3a5f5d591920da2ec810daac240 441 PANTHER PTHR30026 6 440 7.2E-46 T 21-04-2016 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Gene3D G3DSA:3.90.740.10 162 344 1.5E-53 T 21-04-2016 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Hamap MF_02004 Valine--tRNA ligase [valS]. 3 881 14.306 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 SUPERFAMILY SSF47323 589 795 3.55E-41 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Pfam PF10458 Valyl tRNA synthetase tRNA binding arm 817 881 3.5E-12 T 21-04-2016 IPR019499 Valyl-tRNA synthetase, tRNA-binding arm GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 SUPERFAMILY SSF52374 350 588 4.77E-124 T 21-04-2016 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 SUPERFAMILY SSF52374 3 192 4.77E-124 T 21-04-2016 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 15 577 1.8E-176 T 21-04-2016 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Gene3D G3DSA:3.40.50.620 355 529 1.7E-98 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Gene3D G3DSA:3.40.50.620 30 161 1.7E-98 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PANTHER PTHR11946 1 795 0.0 T 21-04-2016 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PANTHER PTHR11946 813 874 0.0 T 21-04-2016 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Gene3D G3DSA:1.10.730.10 530 754 1.4E-61 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 TIGRFAM TIGR00422 valS: valine--tRNA ligase 4 864 2.7E-277 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Pfam PF08264 Anticodon-binding domain of tRNA 618 763 1.8E-34 T 21-04-2016 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 SUPERFAMILY SSF46589 817 881 2.35E-13 T 21-04-2016 IPR010978 tRNA-binding arm GO:0000166 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 Gene3D G3DSA:1.10.287.380 815 880 1.2E-5 T 21-04-2016 IPR019499 Valyl-tRNA synthetase, tRNA-binding arm GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 43 54 - T 21-04-2016 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 SUPERFAMILY SSF50677 191 350 1.19E-56 T 21-04-2016 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PANTHER PTHR11946:SF5 1 795 0.0 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PANTHER PTHR11946:SF5 813 874 0.0 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PRINTS PR00986 Valyl-tRNA synthetase signature 355 368 1.5E-29 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PRINTS PR00986 Valyl-tRNA synthetase signature 457 478 1.5E-29 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PRINTS PR00986 Valyl-tRNA synthetase signature 490 508 1.5E-29 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PRINTS PR00986 Valyl-tRNA synthetase signature 240 257 1.5E-29 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS12180 7080f94f492d5548a6af5c7faaaacc80 881 PRINTS PR00986 Valyl-tRNA synthetase signature 36 47 1.5E-29 T 21-04-2016 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9|Reactome: REACT_71 SPH21_RS05020 c454419a98047ca75a8d4ac768b74fba 639 PANTHER PTHR35803:SF2 1 638 6.4E-162 T 21-04-2016 SPH21_RS05020 c454419a98047ca75a8d4ac768b74fba 639 Pfam PF10566 Glycoside hydrolase 97 291 549 4.6E-68 T 21-04-2016 IPR019563 Glycosyl-hydrolase 97, catalytic domain SPH21_RS05020 c454419a98047ca75a8d4ac768b74fba 639 Gene3D G3DSA:3.20.20.70 301 429 1.5E-7 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS05020 c454419a98047ca75a8d4ac768b74fba 639 PANTHER PTHR35803 1 638 6.4E-162 T 21-04-2016 SPH21_RS05020 c454419a98047ca75a8d4ac768b74fba 639 Pfam PF14508 Glycosyl-hydrolase 97 N-terminal 24 286 2.7E-53 T 21-04-2016 IPR029486 Glycosyl-hydrolase 97, N-terminal domain SPH21_RS05020 c454419a98047ca75a8d4ac768b74fba 639 SUPERFAMILY SSF51445 302 491 4.21E-19 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS05020 c454419a98047ca75a8d4ac768b74fba 639 Pfam PF14509 Glycosyl-hydrolase 97 C-terminal, oligomerisation 552 639 3.8E-20 T 21-04-2016 IPR029483 Glycosyl-hydrolase 97, C-terminal oligomerisation domain SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 51 75 9.3E-32 T 21-04-2016 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|UniPathway: UPA00241 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 4 22 9.3E-32 T 21-04-2016 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|UniPathway: UPA00241 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 22 43 9.3E-32 T 21-04-2016 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|UniPathway: UPA00241 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 87 103 9.3E-32 T 21-04-2016 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|UniPathway: UPA00241 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 114 136 9.3E-32 T 21-04-2016 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|UniPathway: UPA00241 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 Pfam PF01467 Cytidylyltransferase-like 7 135 1.2E-13 T 21-04-2016 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 PANTHER PTHR21342 1 155 4.8E-57 T 21-04-2016 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 5 63 1.1E-11 T 21-04-2016 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 Hamap MF_00151 Phosphopantetheine adenylyltransferase [coaD]. 4 155 27.45 T 21-04-2016 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|UniPathway: UPA00241 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 PANTHER PTHR21342:SF1 1 155 4.8E-57 T 21-04-2016 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 Gene3D G3DSA:3.40.50.620 3 155 1.0E-46 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 SUPERFAMILY SSF52374 3 155 1.16E-38 T 21-04-2016 SPH21_RS15700 842f8e23417f61be6ab86305926ae162 155 TIGRFAM TIGR01510 coaD_prev_kdtB: pantetheine-phosphate adenylyltransferase 5 153 4.5E-48 T 21-04-2016 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3|UniPathway: UPA00241 SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 Pfam PF07676 WD40-like Beta Propeller Repeat 173 201 3.2E-4 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 Pfam PF07676 WD40-like Beta Propeller Repeat 226 250 0.09 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 PANTHER PTHR11731 143 696 5.5E-64 T 21-04-2016 SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 Pfam PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region 272 386 2.6E-11 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 SUPERFAMILY SSF82171 39 404 7.32E-37 T 21-04-2016 SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 Pfam PF00326 Prolyl oligopeptidase family 500 696 1.3E-36 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 SUPERFAMILY SSF53474 441 696 1.54E-55 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 Gene3D G3DSA:3.40.50.1820 441 696 1.8E-60 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 Gene3D G3DSA:2.130.10.10 234 405 3.8E-22 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 Gene3D G3DSA:2.130.10.10 53 233 5.9E-25 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS22430 f83b043a9a2e0ce4fa02f3825d4fa262 701 ProSitePatterns PS00708 Prolyl endopeptidase family serine active site. 541 571 - T 21-04-2016 IPR002471 Peptidase S9, serine active site GO:0004252|GO:0006508 SPH21_RS13145 ceb78ff7bace2fb173b7ef1a2f147880 521 SUPERFAMILY SSF49899 324 519 5.94E-42 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS13145 ceb78ff7bace2fb173b7ef1a2f147880 521 Gene3D G3DSA:2.60.120.200 324 520 1.7E-45 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS13145 ceb78ff7bace2fb173b7ef1a2f147880 521 PANTHER PTHR22925:SF34 20 501 1.6E-74 T 21-04-2016 SPH21_RS13145 ceb78ff7bace2fb173b7ef1a2f147880 521 Gene3D G3DSA:2.115.10.20 27 310 2.1E-57 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS13145 ceb78ff7bace2fb173b7ef1a2f147880 521 Pfam PF04616 Glycosyl hydrolases family 43 28 297 3.3E-34 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS13145 ceb78ff7bace2fb173b7ef1a2f147880 521 PANTHER PTHR22925 20 501 1.6E-74 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS13145 ceb78ff7bace2fb173b7ef1a2f147880 521 SUPERFAMILY SSF75005 28 312 4.59E-60 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 63 294 2.9E-58 T 21-04-2016 SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 55 72 3.0E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 204 223 3.0E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 143 3.0E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 227 244 3.0E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 259 279 3.0E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 194 3.0E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 SUPERFAMILY SSF51735 52 296 3.81E-77 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 184 192 1.0E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 143 1.0E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 204 223 1.0E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 Gene3D G3DSA:3.40.50.720 48 295 2.6E-80 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 191 219 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PANTHER PTHR24322:SF105 58 188 3.3E-64 T 21-04-2016 SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PANTHER PTHR24322:SF105 204 238 3.3E-64 T 21-04-2016 SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PANTHER PTHR24322 58 188 3.3E-64 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18935 54762e32b0b07ec35010da0e1334a5e7 298 PANTHER PTHR24322 204 238 3.3E-64 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Gene3D G3DSA:2.60.120.260 22 187 2.4E-29 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 SUPERFAMILY SSF51445 302 629 3.63E-65 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Gene3D G3DSA:3.20.20.80 311 526 1.7E-68 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Gene3D G3DSA:3.20.20.80 559 632 1.7E-68 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Pfam PF00703 Glycosyl hydrolases family 2 200 305 7.0E-12 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 SUPERFAMILY SSF49785 19 197 4.82E-30 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 PANTHER PTHR10066:SF46 577 674 3.1E-97 T 21-04-2016 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 PANTHER PTHR10066:SF46 61 533 3.1E-97 T 21-04-2016 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Gene3D G3DSA:2.60.40.1560 634 726 4.7E-23 T 21-04-2016 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Gene3D G3DSA:2.60.40.320 188 305 5.8E-18 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Pfam PF16355 Domain of unknown function (DUF4982) 653 713 2.7E-14 T 21-04-2016 IPR032311 Domain of unknown function DUF4982 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 SUPERFAMILY SSF49303 201 305 1.7E-12 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 59 194 5.3E-12 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 311 503 1.2E-25 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 PRINTS PR00132 Glycosyl hydrolase family 2 signature 348 366 1.0E-11 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 PRINTS PR00132 Glycosyl hydrolase family 2 signature 413 428 1.0E-11 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 PRINTS PR00132 Glycosyl hydrolase family 2 signature 317 331 1.0E-11 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 PANTHER PTHR10066 577 674 3.1E-97 T 21-04-2016 SPH21_RS14240 aef4606e1b7347ecbaaf0576c98d6fb1 822 PANTHER PTHR10066 61 533 3.1E-97 T 21-04-2016 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 SUPERFAMILY SSF48256 17 383 4.71E-116 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PRINTS PR00143 Citrate synthase signature 259 279 8.4E-34 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PRINTS PR00143 Citrate synthase signature 206 234 8.4E-34 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PRINTS PR00143 Citrate synthase signature 184 199 8.4E-34 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PRINTS PR00143 Citrate synthase signature 316 332 8.4E-34 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PRINTS PR00143 Citrate synthase signature 336 350 8.4E-34 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PRINTS PR00143 Citrate synthase signature 134 147 8.4E-34 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PIRSF PIRSF001369 10 383 9.5E-102 T 21-04-2016 IPR024176 Citrate synthase, bacterial-type UniPathway: UPA00223 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 TIGRFAM TIGR01800 cit_synth_II: 2-methylcitrate synthase/citrate synthase II 16 383 1.7E-145 T 21-04-2016 IPR011278 2-methylcitrate synthase/citrate synthase type I GO:0005737|GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 Gene3D G3DSA:1.10.580.10 22 245 1.2E-67 T 21-04-2016 IPR016142 Citrate synthase-like, large alpha subdomain UniPathway: UPA00223 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 Pfam PF00285 Citrate synthase, C-terminal domain 17 365 3.5E-106 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PANTHER PTHR11739:SF4 17 383 4.3E-137 T 21-04-2016 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 Gene3D G3DSA:1.10.230.10 246 330 3.1E-26 T 21-04-2016 IPR016143 Citrate synthase-like, small alpha subdomain SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 ProSitePatterns PS00480 Citrate synthase signature. 266 278 - T 21-04-2016 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 UniPathway: UPA00223 SPH21_RS20570 00153892f0e680ce8d66ff6e43e2ed29 383 PANTHER PTHR11739 17 383 4.3E-137 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS13550 5f24de226975dd487859af2be54e076f 665 Gene3D G3DSA:3.40.1090.10 18 101 4.1E-13 T 21-04-2016 SPH21_RS13550 5f24de226975dd487859af2be54e076f 665 SUPERFAMILY SSF52151 24 228 4.19E-19 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS13550 5f24de226975dd487859af2be54e076f 665 SUPERFAMILY SSF52151 313 335 4.19E-19 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS13550 5f24de226975dd487859af2be54e076f 665 Pfam PF01734 Patatin-like phospholipase 27 238 1.4E-15 T 21-04-2016 IPR002641 Patatin/Phospholipase A2-related GO:0006629 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 Gene3D G3DSA:1.10.287.130 349 417 5.1E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SUPERFAMILY SSF55785 225 293 7.5E-10 T 21-04-2016 IPR000014 PAS domain SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 476 574 1.1E-18 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 229 319 3.7E-9 T 21-04-2016 IPR000014 PAS domain SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SUPERFAMILY SSF47384 344 423 1.22E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SUPERFAMILY SSF55874 412 575 2.75E-40 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 PANTHER PTHR24423 228 575 1.6E-80 T 21-04-2016 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 PANTHER PTHR24423 59 78 1.6E-80 T 21-04-2016 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 PANTHER PTHR24423 11 18 1.6E-80 T 21-04-2016 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SMART SM00091 230 296 1.5E-8 T 21-04-2016 IPR000014 PAS domain SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 Gene3D G3DSA:3.30.450.20 227 323 6.5E-11 T 21-04-2016 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SUPERFAMILY SSF158472 169 217 2.35E-10 T 21-04-2016 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 Pfam PF00989 PAS fold 231 295 3.3E-10 T 21-04-2016 IPR013767 PAS fold GO:0006355 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 Pfam PF00672 HAMP domain 149 215 6.2E-11 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 Pfam PF00512 His Kinase A (phospho-acceptor) domain 354 422 2.0E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SMART SM00388 354 422 1.7E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SMART SM00387 468 575 1.4E-26 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 PRINTS PR00344 Bacterial sensor protein C-terminal signature 523 533 1.6E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 PRINTS PR00344 Bacterial sensor protein C-terminal signature 505 519 1.6E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 PRINTS PR00344 Bacterial sensor protein C-terminal signature 561 574 1.6E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 PRINTS PR00344 Bacterial sensor protein C-terminal signature 537 555 1.6E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 Gene3D G3DSA:3.30.565.10 425 575 7.5E-40 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS21085 9b26bc03a4a7df17de0395abfbafed56 575 SMART SM00304 167 219 3.2E-12 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 TIGRFAM TIGR00183 prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent 2 420 2.0E-183 T 21-04-2016 IPR004439 Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 305 324 - T 21-04-2016 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: REACT_1046 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 21 416 1.1E-107 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 SMART SM01329 20 416 6.9E-157 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 Gene3D G3DSA:3.40.718.10 3 420 1.8E-154 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 PANTHER PTHR11835:SF52 277 420 2.0E-213 T 21-04-2016 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 PANTHER PTHR11835:SF52 177 244 2.0E-213 T 21-04-2016 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 PANTHER PTHR11835:SF52 1 154 2.0E-213 T 21-04-2016 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 SUPERFAMILY SSF53659 8 420 6.14E-131 T 21-04-2016 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 PANTHER PTHR11835 277 420 2.0E-213 T 21-04-2016 IPR001804 Isocitrate and isopropylmalate dehydrogenases family GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: REACT_1046 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 PANTHER PTHR11835 177 244 2.0E-213 T 21-04-2016 IPR001804 Isocitrate and isopropylmalate dehydrogenases family GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: REACT_1046 SPH21_RS15665 922210125f58780d150b91ac9bba4504 422 PANTHER PTHR11835 1 154 2.0E-213 T 21-04-2016 IPR001804 Isocitrate and isopropylmalate dehydrogenases family GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: REACT_1046 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 ProSitePatterns PS00211 ABC transporters family signature. 169 183 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 SUPERFAMILY SSF52540 48 273 1.17E-75 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 SMART SM00382 57 246 1.3E-19 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 42 393 4.4E-131 T 21-04-2016 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220 368 379 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220 10 20 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220 45 275 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220 294 326 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 SUPERFAMILY SSF54631 278 393 1.39E-16 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220:SF374 368 379 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220:SF374 10 20 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220:SF374 45 275 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 PANTHER PTHR24220:SF374 294 326 1.6E-156 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 Gene3D G3DSA:3.10.580.10 278 392 1.2E-14 T 21-04-2016 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 Pfam PF00005 ABC transporter 49 196 2.4E-33 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS04010 04b36faf4e7170035eab14db2c3d8267 414 Gene3D G3DSA:3.40.50.300 48 271 1.7E-76 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 Pfam PF13361 UvrD-like helicase C-terminal domain 769 869 8.8E-10 T 21-04-2016 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 Gene3D G3DSA:3.40.50.300 468 614 2.4E-36 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 Gene3D G3DSA:3.40.50.300 765 886 2.4E-36 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 SUPERFAMILY SSF52540 847 871 2.18E-71 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 SUPERFAMILY SSF52540 102 188 2.18E-71 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 SUPERFAMILY SSF52540 6 61 2.18E-71 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 SUPERFAMILY SSF52540 333 493 2.18E-71 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 SUPERFAMILY SSF52540 566 814 2.18E-71 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 Gene3D G3DSA:3.40.50.300 346 449 5.7E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 Gene3D G3DSA:3.40.50.300 10 57 5.7E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 Gene3D G3DSA:3.40.50.300 110 171 5.7E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070 316 515 1.6E-65 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070 846 1114 1.6E-65 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070 102 195 1.6E-65 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070 534 551 1.6E-65 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070 568 811 1.6E-65 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070 9 70 1.6E-65 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070:SF24 316 515 1.6E-65 T 21-04-2016 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070:SF24 846 1114 1.6E-65 T 21-04-2016 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070:SF24 102 195 1.6E-65 T 21-04-2016 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070:SF24 534 551 1.6E-65 T 21-04-2016 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070:SF24 568 811 1.6E-65 T 21-04-2016 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 PANTHER PTHR11070:SF24 9 70 1.6E-65 T 21-04-2016 SPH21_RS06455 7f4cff34558e18ce6d841e2a3ea8f36a 1114 Pfam PF00580 UvrD/REP helicase N-terminal domain 10 449 7.8E-42 T 21-04-2016 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SPH21_RS16945 4fc7ef54dd22af1419bc47f8280f321e 338 PIRSF PIRSF018266 1 336 2.5E-52 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS16945 4fc7ef54dd22af1419bc47f8280f321e 338 PANTHER PTHR30273:SF2 3 338 1.9E-53 T 21-04-2016 SPH21_RS16945 4fc7ef54dd22af1419bc47f8280f321e 338 Pfam PF04773 FecR protein 138 223 3.9E-18 T 21-04-2016 IPR006860 FecR protein SPH21_RS16945 4fc7ef54dd22af1419bc47f8280f321e 338 Pfam PF16344 Domain of unknown function (DUF4974) 233 332 2.3E-10 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS16945 4fc7ef54dd22af1419bc47f8280f321e 338 PANTHER PTHR30273 3 338 1.9E-53 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS19310 bc4e4a0d89557d9cb72b9831bfa14ea3 396 PANTHER PTHR21666 144 392 1.5E-23 T 21-04-2016 SPH21_RS19310 bc4e4a0d89557d9cb72b9831bfa14ea3 396 SUPERFAMILY SSF54001 241 384 9.32E-32 T 21-04-2016 SPH21_RS19310 bc4e4a0d89557d9cb72b9831bfa14ea3 396 Pfam PF00877 NlpC/P60 family 257 362 1.0E-20 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS19310 bc4e4a0d89557d9cb72b9831bfa14ea3 396 Gene3D G3DSA:3.90.1720.10 242 385 2.3E-35 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS19310 bc4e4a0d89557d9cb72b9831bfa14ea3 396 PANTHER PTHR21666:SF186 144 392 1.5E-23 T 21-04-2016 SPH21_RS01865 981a52ce3312c381c5e75acd7eb1467f 184 Pfam PF16117 Domain of unknown function (DUF4833) 42 176 6.5E-49 T 21-04-2016 IPR032269 Domain of unknown function DUF4833 SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 Pfam PF04542 Sigma-70 region 2 16 73 8.3E-13 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 Gene3D G3DSA:1.10.10.10 106 166 1.9E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 PANTHER PTHR30173 5 180 1.7E-33 T 21-04-2016 SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 SUPERFAMILY SSF88946 5 79 1.39E-18 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 6 163 3.4E-24 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 Gene3D G3DSA:1.10.1740.10 5 73 1.5E-21 T 21-04-2016 SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 SUPERFAMILY SSF88659 105 164 4.14E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08420 fa903dc5f118b3ce13c95bdd44acf4c9 180 Pfam PF08281 Sigma-70, region 4 109 159 7.9E-11 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13820 36bc49ad877f9baa04c2b37b59b71d80 396 PANTHER PTHR30273:SF2 185 396 6.4E-69 T 21-04-2016 SPH21_RS13820 36bc49ad877f9baa04c2b37b59b71d80 396 PANTHER PTHR30273:SF2 1 121 6.4E-69 T 21-04-2016 SPH21_RS13820 36bc49ad877f9baa04c2b37b59b71d80 396 Pfam PF04773 FecR protein 184 278 1.1E-19 T 21-04-2016 IPR006860 FecR protein SPH21_RS13820 36bc49ad877f9baa04c2b37b59b71d80 396 PANTHER PTHR30273 185 396 6.4E-69 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS13820 36bc49ad877f9baa04c2b37b59b71d80 396 PANTHER PTHR30273 1 121 6.4E-69 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS13820 36bc49ad877f9baa04c2b37b59b71d80 396 Pfam PF16344 Domain of unknown function (DUF4974) 294 393 3.3E-22 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS16600 dea0b3639996dbfff3d69d76f091c4a7 275 Pfam PF03544 Gram-negative bacterial TonB protein C-terminal 197 269 3.8E-14 T 21-04-2016 IPR006260 TonB, C-terminal GO:0006810 SPH21_RS16600 dea0b3639996dbfff3d69d76f091c4a7 275 SUPERFAMILY SSF74653 191 270 1.7E-17 T 21-04-2016 SPH21_RS16600 dea0b3639996dbfff3d69d76f091c4a7 275 PANTHER PTHR33446 95 269 8.0E-21 T 21-04-2016 SPH21_RS16600 dea0b3639996dbfff3d69d76f091c4a7 275 PANTHER PTHR33446:SF2 95 269 8.0E-21 T 21-04-2016 SPH21_RS15205 db0e651618e1ba43c65374d4ec18ebe0 330 Gene3D G3DSA:3.30.420.10 8 172 3.2E-35 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS15205 db0e651618e1ba43c65374d4ec18ebe0 330 SUPERFAMILY SSF53098 6 175 1.09E-48 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS15205 db0e651618e1ba43c65374d4ec18ebe0 330 Pfam PF00929 Exonuclease 11 165 2.3E-18 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS15205 db0e651618e1ba43c65374d4ec18ebe0 330 PANTHER PTHR30231:SF9 1 261 4.0E-101 T 21-04-2016 SPH21_RS15205 db0e651618e1ba43c65374d4ec18ebe0 330 PANTHER PTHR30231 1 261 4.0E-101 T 21-04-2016 SPH21_RS15205 db0e651618e1ba43c65374d4ec18ebe0 330 SMART SM00479 8 174 1.7E-24 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS26325 52a21e20b8f0bd5504d334a27688165c 291 Pfam PF12704 MacB-like periplasmic core domain 20 246 3.6E-14 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS26325 52a21e20b8f0bd5504d334a27688165c 291 PANTHER PTHR30489 1 195 5.6E-12 T 21-04-2016 SPH21_RS26325 52a21e20b8f0bd5504d334a27688165c 291 PANTHER PTHR30489:SF14 1 195 5.6E-12 T 21-04-2016 SPH21_RS24120 e882a75dd5e898f41b5e125ba21ecfb0 121 PANTHER PTHR33204 6 116 7.2E-35 T 21-04-2016 SPH21_RS24120 e882a75dd5e898f41b5e125ba21ecfb0 121 Gene3D G3DSA:1.10.10.10 10 116 5.1E-36 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24120 e882a75dd5e898f41b5e125ba21ecfb0 121 Pfam PF01638 HxlR-like helix-turn-helix 27 116 1.7E-25 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS24120 e882a75dd5e898f41b5e125ba21ecfb0 121 SUPERFAMILY SSF46785 14 115 5.54E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 Gene3D G3DSA:2.60.120.260 206 327 4.4E-16 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 218 339 1.2E-7 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 PANTHER PTHR22901:SF1 349 604 6.0E-140 T 21-04-2016 SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 PANTHER PTHR22901:SF1 1 191 6.0E-140 T 21-04-2016 SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 Pfam PF03629 Carbohydrate esterase, sialic acid-specific acetylesterase 71 497 1.9E-92 T 21-04-2016 IPR005181 Sialate O-acetylesterase domain SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 PANTHER PTHR22901 349 604 6.0E-140 T 21-04-2016 SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 PANTHER PTHR22901 1 191 6.0E-140 T 21-04-2016 SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 SUPERFAMILY SSF52266 71 175 8.06E-71 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 SUPERFAMILY SSF52266 373 557 8.06E-71 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS13175 be394def32fe5a4d226af114da207fdb 610 SUPERFAMILY SSF49785 211 331 1.81E-18 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS26465 b8f298bd946d91970e9df2e9c6873588 312 PANTHER PTHR30273 50 312 2.3E-59 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26465 b8f298bd946d91970e9df2e9c6873588 312 PANTHER PTHR30273:SF2 50 312 2.3E-59 T 21-04-2016 SPH21_RS26465 b8f298bd946d91970e9df2e9c6873588 312 Pfam PF04773 FecR protein 107 194 1.4E-19 T 21-04-2016 IPR006860 FecR protein SPH21_RS26465 b8f298bd946d91970e9df2e9c6873588 312 PIRSF PIRSF018266 3 310 1.5E-60 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26465 b8f298bd946d91970e9df2e9c6873588 312 Pfam PF16344 Domain of unknown function (DUF4974) 208 305 5.0E-16 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 PANTHER PTHR31956:SF6 2 280 1.1E-106 T 21-04-2016 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 PANTHER PTHR31956:SF6 385 474 1.1E-106 T 21-04-2016 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 TIGRFAM TIGR03396 PC_PLC: phospholipase C, phosphocholine-specific 3 822 6.0E-229 T 21-04-2016 IPR017767 Bacterial phospholipase C, phosphocholine-specific GO:0034480 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 Pfam PF04185 Phosphoesterase family 306 538 3.2E-43 T 21-04-2016 IPR007312 Phosphoesterase GO:0016788 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 Pfam PF04185 Phosphoesterase family 46 281 2.0E-44 T 21-04-2016 IPR007312 Phosphoesterase GO:0016788 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 PANTHER PTHR31956 2 280 1.1E-106 T 21-04-2016 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 PANTHER PTHR31956 494 568 1.1E-106 T 21-04-2016 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 Pfam PF05506 Domain of unknown function (DUF756) 635 718 1.3E-12 T 21-04-2016 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 Pfam PF05506 Domain of unknown function (DUF756) 740 810 1.4E-8 T 21-04-2016 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 PANTHER PTHR31956 385 474 1.1E-106 T 21-04-2016 SPH21_RS08750 39abec53bca560ac022153e7617e8de5 823 PANTHER PTHR31956:SF6 494 568 1.1E-106 T 21-04-2016 SPH21_RS02065 31d08a66741efe08f5fe199cb9db59e3 372 PANTHER PTHR11091:SF0 1 372 9.9E-132 T 21-04-2016 SPH21_RS02065 31d08a66741efe08f5fe199cb9db59e3 372 Pfam PF02615 Malate/L-lactate dehydrogenase 16 357 3.4E-122 T 21-04-2016 IPR003767 Malate/L-lactate dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS02065 31d08a66741efe08f5fe199cb9db59e3 372 Gene3D G3DSA:1.10.1530.10 14 83 2.2E-24 T 21-04-2016 SPH21_RS02065 31d08a66741efe08f5fe199cb9db59e3 372 Gene3D G3DSA:3.30.1370.60 84 293 1.8E-77 T 21-04-2016 SPH21_RS02065 31d08a66741efe08f5fe199cb9db59e3 372 SUPERFAMILY SSF89733 13 366 3.4E-108 T 21-04-2016 IPR003767 Malate/L-lactate dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS02065 31d08a66741efe08f5fe199cb9db59e3 372 PANTHER PTHR11091 1 372 9.9E-132 T 21-04-2016 IPR003767 Malate/L-lactate dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS18495 9d30a9963dfabb332e86f8d88cf37330 124 Pfam PF03733 Inner membrane component domain 4 54 2.8E-19 T 21-04-2016 IPR005185 Inner membrane component domain SPH21_RS18495 9d30a9963dfabb332e86f8d88cf37330 124 Pfam PF03733 Inner membrane component domain 69 119 5.7E-16 T 21-04-2016 IPR005185 Inner membrane component domain SPH21_RS18495 9d30a9963dfabb332e86f8d88cf37330 124 PANTHER PTHR31503:SF17 1 123 1.2E-34 T 21-04-2016 SPH21_RS18495 9d30a9963dfabb332e86f8d88cf37330 124 PANTHER PTHR31503 1 123 1.2E-34 T 21-04-2016 SPH21_RS18495 9d30a9963dfabb332e86f8d88cf37330 124 PIRSF PIRSF028777 1 124 4.1E-44 T 21-04-2016 IPR031308 Uncharacterised conserved protein UCP028777 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 Gene3D G3DSA:1.10.1160.10 257 354 7.5E-31 T 21-04-2016 IPR020061 Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0006418 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 SUPERFAMILY SSF52374 6 338 2.58E-99 T 21-04-2016 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PRINTS PR00987 Glutamyl-tRNA synthetase signature 199 209 7.0E-25 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PRINTS PR00987 Glutamyl-tRNA synthetase signature 39 52 7.0E-25 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PRINTS PR00987 Glutamyl-tRNA synthetase signature 10 22 7.0E-25 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PRINTS PR00987 Glutamyl-tRNA synthetase signature 24 35 7.0E-25 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PRINTS PR00987 Glutamyl-tRNA synthetase signature 215 223 7.0E-25 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PANTHER PTHR11451:SF41 1 252 2.8E-95 T 21-04-2016 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PANTHER PTHR11451:SF41 284 368 2.8E-95 T 21-04-2016 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 Gene3D G3DSA:1.10.10.350 404 500 4.4E-22 T 21-04-2016 IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 SUPERFAMILY SSF48163 340 500 6.02E-39 T 21-04-2016 IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding GO:0000049 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 Gene3D G3DSA:3.90.800.10 72 200 9.5E-36 T 21-04-2016 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 13 24 - T 21-04-2016 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 Pfam PF00749 tRNA synthetases class I (E and Q), catalytic domain 6 346 1.4E-89 T 21-04-2016 IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain GO:0005524|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 TIGRFAM TIGR00464 gltX_bact: glutamate--tRNA ligase 6 502 2.4E-139 T 21-04-2016 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 Hamap MF_00022_B Glutamate--tRNA ligase [gltX]. 7 502 30.984 T 21-04-2016 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PANTHER PTHR11451 1 252 2.8E-95 T 21-04-2016 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 PANTHER PTHR11451 284 368 2.8E-95 T 21-04-2016 SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 Gene3D G3DSA:3.40.50.620 201 252 1.2E-44 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS07070 7181daa05d6e9de1301ff85363e1e429 507 Gene3D G3DSA:3.40.50.620 6 71 1.2E-44 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 Hamap MF_00037 UDP-N-acetylenolpyruvoylglucosamine reductase [murB]. 1 339 75.095 T 21-04-2016 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 SUPERFAMILY SSF56176 8 197 6.54E-43 T 21-04-2016 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 Gene3D G3DSA:3.90.78.10 238 339 8.3E-38 T 21-04-2016 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 Pfam PF01565 FAD binding domain 23 152 2.4E-18 T 21-04-2016 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 PANTHER PTHR21071 1 338 8.2E-135 T 21-04-2016 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 Gene3D G3DSA:3.30.465.10 76 237 3.3E-50 T 21-04-2016 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 Gene3D G3DSA:3.30.43.10 7 72 6.9E-21 T 21-04-2016 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 TIGRFAM TIGR00179 murB: UDP-N-acetylenolpyruvoylglucosamine reductase 9 338 2.2E-71 T 21-04-2016 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 SUPERFAMILY SSF56194 210 338 1.7E-43 T 21-04-2016 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 PANTHER PTHR21071:SF6 1 338 8.2E-135 T 21-04-2016 SPH21_RS08415 403e81a72be10950c66849f861a23b16 339 Pfam PF02873 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain 214 337 2.8E-32 T 21-04-2016 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS01305 5b68970b27ebda0f2a8f27c462aea718 447 PANTHER PTHR10681:SF68 1 256 7.7E-16 T 21-04-2016 SPH21_RS01305 5b68970b27ebda0f2a8f27c462aea718 447 Pfam PF08534 Redoxin 34 155 6.0E-11 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS01305 5b68970b27ebda0f2a8f27c462aea718 447 SUPERFAMILY SSF52833 6 156 9.51E-19 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS01305 5b68970b27ebda0f2a8f27c462aea718 447 Gene3D G3DSA:3.40.30.10 1 173 1.5E-25 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS01305 5b68970b27ebda0f2a8f27c462aea718 447 PANTHER PTHR10681 1 256 7.7E-16 T 21-04-2016 SPH21_RS01305 5b68970b27ebda0f2a8f27c462aea718 447 ProSitePatterns PS00194 Thioredoxin family active site. 65 83 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 172 6.9E-5 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 6.9E-5 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 1.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 191 1.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 1.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 1.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 127 143 1.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 153 172 1.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 140 168 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 Gene3D G3DSA:3.40.50.720 1 249 1.8E-77 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 249 4.2E-62 T 21-04-2016 SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 SUPERFAMILY SSF51735 4 249 8.42E-75 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PANTHER PTHR24321 1 250 6.9E-48 T 21-04-2016 SPH21_RS04600 f74fa9cd2b1cf22a6f79061f9f6700fa 255 PANTHER PTHR24321:SF6 1 250 6.9E-48 T 21-04-2016 SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 PANTHER PTHR10625 10 288 1.1E-96 T 21-04-2016 IPR000286 Histone deacetylase superfamily SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 PANTHER PTHR10625:SF131 10 288 1.1E-96 T 21-04-2016 SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 SUPERFAMILY SSF52768 4 281 6.71E-74 T 21-04-2016 SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 PRINTS PR01270 Histone deacetylase superfamily signature 116 139 2.1E-12 T 21-04-2016 IPR000286 Histone deacetylase superfamily SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 PRINTS PR01270 Histone deacetylase superfamily signature 150 165 2.1E-12 T 21-04-2016 IPR000286 Histone deacetylase superfamily SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 PRINTS PR01270 Histone deacetylase superfamily signature 224 234 2.1E-12 T 21-04-2016 IPR000286 Histone deacetylase superfamily SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 Gene3D G3DSA:3.40.800.20 4 289 3.4E-59 T 21-04-2016 IPR023801 Histone deacetylase domain SPH21_RS15125 27a4c38cc9f49e26763f6fcc863ce33a 300 Pfam PF00850 Histone deacetylase domain 38 281 3.0E-47 T 21-04-2016 IPR023801 Histone deacetylase domain SPH21_RS03475 3b3840b6394b4077e9c538e3a6a0bc16 475 Gene3D G3DSA:3.30.1330.90 14 160 1.7E-49 T 21-04-2016 IPR029009 Allosteric substrate binding domain SPH21_RS03475 3b3840b6394b4077e9c538e3a6a0bc16 475 Pfam PF03313 Serine dehydratase alpha chain 187 465 6.4E-93 T 21-04-2016 IPR005130 Serine dehydratase-like, alpha subunit SPH21_RS03475 3b3840b6394b4077e9c538e3a6a0bc16 475 Pfam PF03315 Serine dehydratase beta chain 7 159 1.9E-53 T 21-04-2016 IPR005131 Serine dehydratase beta chain GO:0003941|GO:0006094|GO:0051539 KEGG: 00260+4.3.1.17|KEGG: 00270+4.3.1.17|UniPathway: UPA00138 SPH21_RS03475 3b3840b6394b4077e9c538e3a6a0bc16 475 SUPERFAMILY SSF143548 20 159 3.4E-43 T 21-04-2016 IPR029009 Allosteric substrate binding domain SPH21_RS03475 3b3840b6394b4077e9c538e3a6a0bc16 475 PANTHER PTHR30182 1 468 9.8E-194 T 21-04-2016 SPH21_RS03475 3b3840b6394b4077e9c538e3a6a0bc16 475 PANTHER PTHR30182:SF1 1 468 9.8E-194 T 21-04-2016 SPH21_RS03475 3b3840b6394b4077e9c538e3a6a0bc16 475 TIGRFAM TIGR00720 sda_mono: L-serine ammonia-lyase 6 468 5.3E-177 T 21-04-2016 IPR004644 Iron-sulphur-dependent L-serine dehydratase single chain form GO:0003941|GO:0006094 KEGG: 00260+4.3.1.17|KEGG: 00270+4.3.1.17|UniPathway: UPA00138 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 Pfam PF00501 AMP-binding enzyme 68 511 1.0E-87 T 21-04-2016 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 Pfam PF13193 AMP-binding enzyme C-terminal domain 520 598 9.1E-20 T 21-04-2016 IPR025110 AMP-binding enzyme C-terminal domain SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 ProSitePatterns PS00455 Putative AMP-binding domain signature. 249 260 - T 21-04-2016 IPR020845 AMP-binding, conserved site SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 Gene3D G3DSA:3.30.300.30 507 631 3.0E-24 T 21-04-2016 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus 11 66 2.3E-22 T 21-04-2016 IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 SUPERFAMILY SSF56801 3 630 3.53E-169 T 21-04-2016 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 TIGRFAM TIGR02188 Ac_CoA_lig_AcsA: acetate--CoA ligase 7 632 3.7E-279 T 21-04-2016 IPR011904 Acetate-CoA ligase GO:0003987|GO:0016208|GO:0019427 KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118|Reactome: REACT_13433 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 Gene3D G3DSA:3.40.50.980 255 411 1.3E-28 T 21-04-2016 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 Gene3D G3DSA:2.30.38.10 428 504 2.8E-8 T 21-04-2016 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 Gene3D G3DSA:3.40.50.980 65 254 2.7E-40 T 21-04-2016 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 PANTHER PTHR24095 5 630 0.0 T 21-04-2016 SPH21_RS25495 cdefdeb642c3270aaea92da22cf45724 639 PANTHER PTHR24095:SF178 5 630 0.0 T 21-04-2016 SPH21_RS01130 7c037cef379bebe348533440e99a8662 358 Pfam PF01758 Sodium Bile acid symporter family 60 256 2.5E-66 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS01130 7c037cef379bebe348533440e99a8662 358 PIRSF PIRSF005508 2 357 1.9E-136 T 21-04-2016 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SPH21_RS01130 7c037cef379bebe348533440e99a8662 358 PANTHER PTHR10361:SF31 13 355 8.7E-154 T 21-04-2016 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SPH21_RS01130 7c037cef379bebe348533440e99a8662 358 PANTHER PTHR10361 13 355 8.7E-154 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS01130 7c037cef379bebe348533440e99a8662 358 TIGRFAM TIGR00832 acr3: arsenical-resistance protein 15 344 8.4E-137 T 21-04-2016 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 SUPERFAMILY SSF53383 6 394 2.76E-119 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 Hamap MF_00985 2-amino-3-ketobutyrate coenzyme A ligase [kbl]. 2 393 54.278 T 21-04-2016 IPR011282 2-amino-3-ketobutyrate coenzyme A ligase GO:0006567|GO:0008890 KEGG: 00260+2.3.1.29|UniPathway: UPA00046 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 239 248 - T 21-04-2016 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 PANTHER PTHR13693 1 396 6.4E-267 T 21-04-2016 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 Pfam PF00155 Aminotransferase class I and II 43 384 3.2E-71 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 Gene3D G3DSA:3.40.640.10 60 276 1.3E-87 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 TIGRFAM TIGR01822 2am3keto_CoA: glycine C-acetyltransferase 7 395 2.5E-212 T 21-04-2016 IPR011282 2-amino-3-ketobutyrate coenzyme A ligase GO:0006567|GO:0008890 KEGG: 00260+2.3.1.29|UniPathway: UPA00046 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 PANTHER PTHR13693:SF60 1 396 6.4E-267 T 21-04-2016 SPH21_RS07195 7fb19cdbdc9517498cce966c9b58cd72 396 Gene3D G3DSA:3.90.1150.10 277 391 7.0E-31 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 Pfam PF01832 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase 83 208 1.4E-24 T 21-04-2016 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 SUPERFAMILY SSF54106 252 295 7.72E-11 T 21-04-2016 IPR018392 LysM domain SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 PANTHER PTHR33308:SF3 70 214 9.3E-21 T 21-04-2016 SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 SMART SM00257 253 296 2.3E-13 T 21-04-2016 IPR018392 LysM domain SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 Pfam PF01476 LysM domain 254 296 2.0E-12 T 21-04-2016 IPR018392 LysM domain SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 Gene3D G3DSA:3.10.350.10 252 295 3.6E-15 T 21-04-2016 IPR018392 LysM domain SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 PANTHER PTHR33308 70 214 9.3E-21 T 21-04-2016 SPH21_RS03785 815c27005747d5faa4d92f49c58e1c14 297 SMART SM00047 65 213 1.0E-30 T 21-04-2016 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1075 1088 3.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1034 1044 3.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1051 1069 3.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1016 1030 3.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF07495 Y_Y_Y domain 733 795 5.7E-21 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SUPERFAMILY SSF63829 511 670 2.45E-16 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:2.120.10.30 376 484 1.2E-8 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 973 1089 7.0E-23 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:1.10.287.130 852 912 4.3E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SUPERFAMILY SSF46689 1325 1373 2.91E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SMART SM00342 1288 1371 5.2E-28 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 1322 1367 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF00512 His Kinase A (phospho-acceptor) domain 862 925 1.2E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SUPERFAMILY SSF47384 849 926 3.34E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SMART SM00448 1126 1238 3.0E-34 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:3.30.565.10 913 1090 1.9E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:1.10.10.60 1267 1323 4.8E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:2.120.10.30 513 676 1.1E-15 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:2.120.10.30 53 248 1.5E-10 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:3.40.50.2300 1124 1253 2.3E-38 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423 781 814 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423 80 202 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423 441 460 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423 557 630 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423 837 1280 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF12833 Helix-turn-helix domain 1295 1372 2.4E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SUPERFAMILY SSF55874 915 1086 8.25E-38 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SUPERFAMILY SSF50998 45 491 3.14E-16 T 21-04-2016 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SMART SM00388 861 926 1.0E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF00072 Response regulator receiver domain 1128 1238 4.7E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423:SF486 781 814 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423:SF486 80 202 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423:SF486 441 460 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423:SF486 557 630 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 PANTHER PTHR24423:SF486 837 1280 6.8E-121 T 21-04-2016 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF07494 Two component regulator propeller 512 533 0.0013 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF07494 Two component regulator propeller 555 577 3.2E-5 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF07494 Two component regulator propeller 84 107 1.3E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF07494 Two component regulator propeller 460 482 3.8E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF07494 Two component regulator propeller 317 339 0.011 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Pfam PF07494 Two component regulator propeller 224 246 0.013 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 Gene3D G3DSA:1.10.10.60 1325 1370 4.4E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SUPERFAMILY SSF52172 1126 1255 5.69E-35 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS13165 94fa25719bfe5cdd512b21a8bff4536a 1386 SMART SM00387 972 1091 1.4E-31 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 SUPERFAMILY SSF52540 19 139 1.02E-17 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 Pfam PF13173 AAA domain 21 136 1.1E-25 T 21-04-2016 SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 Gene3D G3DSA:3.40.50.300 169 197 1.1E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 Gene3D G3DSA:3.40.50.300 232 253 1.1E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 PANTHER PTHR33295 1 353 9.5E-87 T 21-04-2016 SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 PANTHER PTHR33295:SF5 1 353 9.5E-87 T 21-04-2016 SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 Gene3D G3DSA:3.40.50.300 13 126 1.3E-8 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04155 d20a222a1556251989e3361c433ed7b5 388 Pfam PF13635 Domain of unknown function (DUF4143) 178 336 1.2E-29 T 21-04-2016 IPR025420 Domain of unknown function DUF4143 SPH21_RS01665 e5f11b2f2e578399db2affc3cc9ee59b 605 PANTHER PTHR11361 328 587 7.5E-56 T 21-04-2016 SPH21_RS01665 e5f11b2f2e578399db2affc3cc9ee59b 605 Pfam PF00488 MutS domain V 430 588 9.1E-29 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS01665 e5f11b2f2e578399db2affc3cc9ee59b 605 SUPERFAMILY SSF48334 130 180 9.02E-5 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS01665 e5f11b2f2e578399db2affc3cc9ee59b 605 SUPERFAMILY SSF52540 394 603 1.33E-28 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01665 e5f11b2f2e578399db2affc3cc9ee59b 605 SMART SM00534 426 597 2.2E-12 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS01665 e5f11b2f2e578399db2affc3cc9ee59b 605 Gene3D G3DSA:3.40.50.300 393 602 3.8E-40 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01665 e5f11b2f2e578399db2affc3cc9ee59b 605 Gene3D G3DSA:1.10.1420.10 125 194 7.1E-5 T 21-04-2016 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PANTHER PTHR10422 1 543 9.5E-199 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 SUPERFAMILY SSF81442 2 532 5.1E-148 T 21-04-2016 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 2 479 3.9E-135 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 Gene3D G3DSA:1.20.210.10 2 559 8.6E-174 T 21-04-2016 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PANTHER PTHR10422:SF6 1 543 9.5E-199 T 21-04-2016 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 252 306 - T 21-04-2016 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 82 106 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 355 373 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 320 341 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 54 77 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 160 178 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 296 311 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 383 402 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 433 454 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS09455 2001b451aa5803130173b1ad5faeecf4 593 PRINTS PR01165 Cytochrome c oxidase subunit I signature 125 137 4.3E-68 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 PANTHER PTHR26402:SF524 2 117 2.4E-36 T 21-04-2016 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 SUPERFAMILY SSF52172 1 128 1.71E-29 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 Gene3D G3DSA:3.40.50.2300 1 127 9.3E-32 T 21-04-2016 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 Pfam PF00072 Response regulator receiver domain 5 109 2.2E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 SMART SM00850 150 247 1.9E-28 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 Pfam PF04397 LytTr DNA-binding domain 151 246 2.3E-21 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 PANTHER PTHR26402 2 117 2.4E-36 T 21-04-2016 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 Gene3D G3DSA:2.40.50.40 142 209 7.4E-20 T 21-04-2016 SPH21_RS11780 22693573f8fba0f89db61a04341a45e3 248 SMART SM00448 2 110 2.1E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 SUPERFAMILY SSF51445 308 593 2.81E-59 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 354 484 5.6E-9 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 66 211 9.5E-15 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 Pfam PF00703 Glycosyl hydrolases family 2 217 311 3.7E-10 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 Gene3D G3DSA:3.20.20.80 324 593 3.3E-49 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 SUPERFAMILY SSF49785 46 216 1.18E-47 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 Gene3D G3DSA:2.60.120.260 45 204 7.7E-54 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 PANTHER PTHR10066 1 614 8.7E-252 T 21-04-2016 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 PANTHER PTHR10066:SF44 1 614 8.7E-252 T 21-04-2016 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 SUPERFAMILY SSF49303 217 312 1.38E-12 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS02965 af911928bdaec21d4a9e66ab4e5e2ddf 615 Gene3D G3DSA:2.60.40.320 205 312 2.3E-23 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 Pfam PF07687 Peptidase dimerisation domain 193 285 4.3E-11 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 PANTHER PTHR11014 3 392 1.3E-153 T 21-04-2016 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 PANTHER PTHR11014:SF63 3 392 1.3E-153 T 21-04-2016 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 Pfam PF01546 Peptidase family M20/M25/M40 75 386 2.1E-31 T 21-04-2016 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 Gene3D G3DSA:3.40.630.10 303 392 1.4E-94 T 21-04-2016 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 Gene3D G3DSA:3.40.630.10 1 183 1.4E-94 T 21-04-2016 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 TIGRFAM TIGR01891 amidohydrolases: amidohydrolase 17 379 1.2E-108 T 21-04-2016 IPR017439 Amidohydrolase GO:0016787 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 PIRSF PIRSF005962 1 394 5.2E-127 T 21-04-2016 IPR017439 Amidohydrolase GO:0016787 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 SUPERFAMILY SSF55031 189 301 8.11E-31 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 SUPERFAMILY SSF53187 303 392 1.41E-79 T 21-04-2016 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 SUPERFAMILY SSF53187 4 202 1.41E-79 T 21-04-2016 SPH21_RS03335 5632a5cbc70d4e6e87d9bc5ee55954fc 394 Gene3D G3DSA:3.30.70.360 186 302 1.8E-41 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 19 177 2.9E-25 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 SUPERFAMILY SSF88659 120 179 7.85E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 Pfam PF08281 Sigma-70, region 4 126 173 8.6E-14 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 20 177 1.2E-43 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 Pfam PF04542 Sigma-70 region 2 24 89 1.7E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 PANTHER PTHR30173 6 191 1.4E-46 T 21-04-2016 SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 Gene3D G3DSA:1.10.10.10 119 179 2.1E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 SUPERFAMILY SSF88946 3 98 3.37E-23 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 PANTHER PTHR30173:SF20 6 191 1.4E-46 T 21-04-2016 SPH21_RS21460 cbbe9034a052c65bd375c302068b430a 196 Gene3D G3DSA:1.10.1740.10 3 98 5.1E-24 T 21-04-2016 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 TIGRFAM TIGR01017 rpsD_bact: ribosomal protein uS4 3 202 1.8E-74 T 21-04-2016 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 Gene3D G3DSA:3.10.290.10 96 194 4.8E-30 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 Hamap MF_01306_B 30S ribosomal protein S4 [rpsD]. 1 202 34.173 T 21-04-2016 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 Pfam PF00163 Ribosomal protein S4/S9 N-terminal domain 3 92 8.3E-26 T 21-04-2016 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 Gene3D G3DSA:1.10.1050.10 1 95 4.0E-37 T 21-04-2016 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 SMART SM01390 3 92 8.4E-42 T 21-04-2016 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 SMART SM00363 93 154 1.7E-14 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 SUPERFAMILY SSF55174 3 202 2.88E-63 T 21-04-2016 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 Pfam PF01479 S4 domain 94 140 6.0E-18 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 ProSitePatterns PS00632 Ribosomal protein S4 signature. 91 115 - T 21-04-2016 IPR018079 Ribosomal protein S4, conserved site GO:0005622|GO:0019843 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 PANTHER PTHR11831 1 202 4.2E-76 T 21-04-2016 IPR022801 Ribosomal protein S4/S9 SPH21_RS08620 7a6ed7dea739f7e9c0479b21ebea6668 202 PANTHER PTHR11831:SF4 1 202 4.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 3 328 9.3E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 Gene3D G3DSA:3.50.50.60 140 334 4.3E-54 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 SUPERFAMILY SSF51905 1 338 4.5E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 347 456 1.1E-37 T 21-04-2016 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PIRSF PIRSF000350 1 463 3.9E-94 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 SUPERFAMILY SSF55424 344 462 6.01E-40 T 21-04-2016 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PANTHER PTHR22912 2 459 8.6E-229 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 175 193 3.3E-37 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 5 24 3.3E-37 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 263 279 3.3E-37 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 293 315 3.3E-37 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 136 154 3.3E-37 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 ProSitePatterns PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 38 48 - T 21-04-2016 IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site GO:0016668|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 Gene3D G3DSA:3.50.50.60 1 139 1.2E-45 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 2 463 1.7E-174 T 21-04-2016 IPR006258 Dihydrolipoamide dehydrogenase GO:0004148|GO:0050660|GO:0055114 KEGG: 00010+1.8.1.4|KEGG: 00020+1.8.1.4|KEGG: 00260+1.8.1.4|KEGG: 00280+1.8.1.4|KEGG: 00620+1.8.1.4|KEGG: 00640+1.8.1.4|MetaCyc: PWY-5046|MetaCyc: PWY-5084 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 430 450 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 175 200 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 264 278 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 139 148 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 37 52 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 4 26 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 308 315 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 343 364 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 408 423 1.2E-76 T 21-04-2016 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 Gene3D G3DSA:3.30.390.30 335 462 3.6E-47 T 21-04-2016 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SPH21_RS08365 26b3069f6d2a2ad2809a3b3e0320d457 467 PANTHER PTHR22912:SF151 2 459 8.6E-229 T 21-04-2016 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 Gene3D G3DSA:3.30.300.10 10 131 3.3E-44 T 21-04-2016 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 PANTHER PTHR11964:SF1 400 410 1.1E-202 T 21-04-2016 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 PANTHER PTHR11964:SF1 3 380 1.1E-202 T 21-04-2016 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 Pfam PF00438 S-adenosylmethionine synthetase, N-terminal domain 3 100 3.6E-40 T 21-04-2016 IPR022628 S-adenosylmethionine synthetase, N-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 TIGRFAM TIGR01034 metK: methionine adenosyltransferase 4 384 1.5E-151 T 21-04-2016 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 Hamap MF_00086 S-adenosylmethionine synthase [metK]. 1 415 49.582 T 21-04-2016 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 SUPERFAMILY SSF55973 112 243 9.42E-38 T 21-04-2016 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 ProSitePatterns PS00377 S-adenosylmethionine synthase signature 2. 270 278 - T 21-04-2016 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 PANTHER PTHR11964 400 410 1.1E-202 T 21-04-2016 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 PANTHER PTHR11964 3 380 1.1E-202 T 21-04-2016 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 ProSitePatterns PS00376 S-adenosylmethionine synthase signature 1. 115 125 - T 21-04-2016 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 Pfam PF02772 S-adenosylmethionine synthetase, central domain 113 242 3.2E-41 T 21-04-2016 IPR022629 S-adenosylmethionine synthetase, central domain GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 Gene3D G3DSA:3.30.300.10 255 415 3.0E-62 T 21-04-2016 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 Pfam PF02773 S-adenosylmethionine synthetase, C-terminal domain 244 379 1.5E-61 T 21-04-2016 IPR022630 S-adenosylmethionine synthetase, C-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 PIRSF PIRSF000497 1 416 3.9E-161 T 21-04-2016 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 Gene3D G3DSA:3.30.300.10 132 244 5.8E-34 T 21-04-2016 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 SUPERFAMILY SSF55973 244 413 8.24E-57 T 21-04-2016 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS07805 f71d303fbc35f75fe140e6e50f9761d5 417 SUPERFAMILY SSF55973 2 108 2.51E-42 T 21-04-2016 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: REACT_13433|UniPathway: UPA00315 SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 Gene3D G3DSA:1.10.10.10 151 225 6.6E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 Pfam PF00027 Cyclic nucleotide-binding domain 35 120 8.9E-15 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 SMART SM00100 15 136 7.5E-9 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 PANTHER PTHR24567 19 226 8.1E-38 T 21-04-2016 SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 Pfam PF13545 Crp-like helix-turn-helix domain 153 225 7.6E-12 T 21-04-2016 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 SUPERFAMILY SSF51206 11 148 4.98E-30 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 Gene3D G3DSA:2.60.120.10 13 148 8.6E-28 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 SUPERFAMILY SSF46785 151 226 1.82E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16095 5e076a627a4234859f83e73618793b3e 228 SMART SM00419 170 218 0.003 T 21-04-2016 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 64 73 1.7E-23 T 21-04-2016 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 28 39 1.7E-23 T 21-04-2016 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 239 260 1.7E-23 T 21-04-2016 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 208 226 1.7E-23 T 21-04-2016 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 SUPERFAMILY SSF47323 360 486 2.62E-29 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 SMART SM00840 370 436 4.0E-12 T 21-04-2016 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 SUPERFAMILY SSF52374 7 336 2.56E-78 T 21-04-2016 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 Gene3D G3DSA:1.20.120.640 332 426 6.3E-19 T 21-04-2016 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 PANTHER PTHR10890 1 484 1.3E-165 T 21-04-2016 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 Gene3D G3DSA:3.40.50.620 22 330 8.3E-87 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 TIGRFAM TIGR00435 cysS: cysteine--tRNA ligase 5 486 2.3E-132 T 21-04-2016 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16|Reactome: REACT_71 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 Pfam PF09190 DALR domain 370 433 2.8E-12 T 21-04-2016 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 Hamap MF_00041 Cysteine--tRNA ligase [cysS]. 5 487 33.909 T 21-04-2016 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16|Reactome: REACT_71 SPH21_RS07260 d2de88fd1a1c5b3821e036596c89e4ec 487 Pfam PF01406 tRNA synthetases class I (C) catalytic domain 18 337 5.5E-93 T 21-04-2016 IPR032678 tRNA synthetases class I, catalytic domain KEGG: 00970+6.1.1.16 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 92 103 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 SUPERFAMILY SSF54862 8 158 1.78E-43 T 21-04-2016 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 Gene3D G3DSA:3.30.70.20 98 130 4.7E-11 T 21-04-2016 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 PANTHER PTHR11938:SF88 5 154 7.2E-32 T 21-04-2016 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 Gene3D G3DSA:3.30.70.20 65 97 1.5E-11 T 21-04-2016 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 PANTHER PTHR11938 5 154 7.2E-32 T 21-04-2016 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 Gene3D G3DSA:3.30.70.20 9 64 4.1E-21 T 21-04-2016 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 Gene3D G3DSA:3.30.70.20 131 160 4.1E-21 T 21-04-2016 SPH21_RS13365 cf8659cdaf3edc997fffd7bec47201a2 189 Pfam PF13247 4Fe-4S dicluster domain 55 147 9.6E-21 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS24710 97497bb3b5b43a90516b4ff82744edf5 847 PANTHER PTHR38478 47 782 1.7E-101 T 21-04-2016 SPH21_RS24710 97497bb3b5b43a90516b4ff82744edf5 847 Gene3D G3DSA:3.40.390.10 297 495 9.3E-10 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS24710 97497bb3b5b43a90516b4ff82744edf5 847 SUPERFAMILY SSF55486 305 510 4.55E-27 T 21-04-2016 SPH21_RS24710 97497bb3b5b43a90516b4ff82744edf5 847 Pfam PF16313 Met-zincin 433 736 4.9E-69 T 21-04-2016 IPR032534 Domian of unknown function DUF4953 SPH21_RS24710 97497bb3b5b43a90516b4ff82744edf5 847 Pfam PF17162 Domain of unknown function (DUF5118) 43 86 1.2E-8 T 21-04-2016 IPR033428 Domain of unknown function DUF5118 SPH21_RS24710 97497bb3b5b43a90516b4ff82744edf5 847 Pfam PF17148 Domain of unknown function (DUF5117) 102 304 3.5E-37 T 21-04-2016 IPR033413 Domain of unknown function DUF5117 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 SUPERFAMILY SSF46689 247 292 3.81E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 PANTHER PTHR11019 43 291 2.8E-39 T 21-04-2016 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 SUPERFAMILY SSF51215 47 143 3.66E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 Gene3D G3DSA:1.10.10.60 247 294 2.0E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 259 274 7.6E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 274 290 7.6E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 Gene3D G3DSA:2.60.120.280 47 136 3.6E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 PANTHER PTHR11019:SF45 43 291 2.8E-39 T 21-04-2016 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 SMART SM00342 207 290 2.0E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09515 f0fdf8350a862812a37ce48376921edb 297 Pfam PF12833 Helix-turn-helix domain 213 291 5.3E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS06030 9282b7ff7df58bb31b183aa524d68341 806 PANTHER PTHR30572:SF4 416 806 2.7E-85 T 21-04-2016 SPH21_RS06030 9282b7ff7df58bb31b183aa524d68341 806 PANTHER PTHR30572:SF4 291 359 2.7E-85 T 21-04-2016 SPH21_RS06030 9282b7ff7df58bb31b183aa524d68341 806 PANTHER PTHR30572 416 806 2.7E-85 T 21-04-2016 SPH21_RS06030 9282b7ff7df58bb31b183aa524d68341 806 PANTHER PTHR30572 291 359 2.7E-85 T 21-04-2016 SPH21_RS06030 9282b7ff7df58bb31b183aa524d68341 806 Pfam PF02687 FtsX-like permease family 294 409 9.8E-17 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06030 9282b7ff7df58bb31b183aa524d68341 806 Pfam PF02687 FtsX-like permease family 686 799 1.8E-12 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06030 9282b7ff7df58bb31b183aa524d68341 806 Pfam PF12704 MacB-like periplasmic core domain 16 242 9.0E-16 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 ProSitePatterns PS00157 Ribulose bisphosphate carboxylase large chain active site. 175 183 - T 21-04-2016 IPR020878 Ribulose bisphosphate carboxylase, large chain, active site GO:0000287|GO:0015977|GO:0016984 KEGG: 00630+4.1.1.39|KEGG: 00710+4.1.1.39|MetaCyc: PWY-5532|MetaCyc: PWY-5723 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 PANTHER PTHR23321:SF19 1 302 5.3E-43 T 21-04-2016 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 Pfam PF00016 Ribulose bisphosphate carboxylase large chain, catalytic domain 133 411 2.6E-80 T 21-04-2016 IPR000685 Ribulose bisphosphate carboxylase, large subunit, C-terminal GO:0000287 KEGG: 00630+4.1.1.39|KEGG: 00710+4.1.1.39|MetaCyc: PWY-5532|MetaCyc: PWY-5723 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 SUPERFAMILY SSF51649 128 412 3.93E-80 T 21-04-2016 IPR000685 Ribulose bisphosphate carboxylase, large subunit, C-terminal GO:0000287 KEGG: 00630+4.1.1.39|KEGG: 00710+4.1.1.39|MetaCyc: PWY-5532|MetaCyc: PWY-5723 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 Gene3D G3DSA:3.20.20.110 128 413 2.2E-72 T 21-04-2016 IPR000685 Ribulose bisphosphate carboxylase, large subunit, C-terminal GO:0000287 KEGG: 00630+4.1.1.39|KEGG: 00710+4.1.1.39|MetaCyc: PWY-5532|MetaCyc: PWY-5723 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 Gene3D G3DSA:3.30.70.150 1 127 2.8E-40 T 21-04-2016 IPR017443 Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal GO:0015977|GO:0016984 KEGG: 00630+4.1.1.39|KEGG: 00710+4.1.1.39|MetaCyc: PWY-5532|MetaCyc: PWY-5723 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 SUPERFAMILY SSF54966 1 127 1.83E-37 T 21-04-2016 IPR017443 Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal GO:0015977|GO:0016984 KEGG: 00630+4.1.1.39|KEGG: 00710+4.1.1.39|MetaCyc: PWY-5532|MetaCyc: PWY-5723 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 Pfam PF02788 Ribulose bisphosphate carboxylase large chain, N-terminal domain 3 123 1.5E-8 T 21-04-2016 IPR017443 Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal GO:0015977|GO:0016984 KEGG: 00630+4.1.1.39|KEGG: 00710+4.1.1.39|MetaCyc: PWY-5532|MetaCyc: PWY-5723 SPH21_RS10640 d2bad320e81568405b16de866cc93d3c 414 PANTHER PTHR23321 1 302 5.3E-43 T 21-04-2016 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 292 502 3.9E-35 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 TIGRFAM TIGR01234 L-ribulokinase: ribulokinase 4 551 6.7E-183 T 21-04-2016 IPR005929 Ribulokinase GO:0005524|GO:0008741|GO:0019569 KEGG: 00040+2.7.1.16|UniPathway: UPA00145 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 Hamap MF_00520 Ribulokinase [araB]. 3 560 44.459 T 21-04-2016 IPR005929 Ribulokinase GO:0005524|GO:0008741|GO:0019569 KEGG: 00040+2.7.1.16|UniPathway: UPA00145 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 PANTHER PTHR10196 1 560 5.3E-209 T 21-04-2016 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 PIRSF PIRSF000538 3 554 1.2E-47 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 SUPERFAMILY SSF53067 5 281 1.81E-28 T 21-04-2016 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 SUPERFAMILY SSF53067 283 545 9.07E-47 T 21-04-2016 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 Gene3D G3DSA:3.30.420.40 285 544 1.5E-50 T 21-04-2016 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 5 281 2.2E-13 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 PANTHER PTHR10196:SF62 1 560 5.3E-209 T 21-04-2016 SPH21_RS05055 b297ee31451ace9f658505c22adb6804 563 Gene3D G3DSA:3.30.420.40 2 281 1.1E-37 T 21-04-2016 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 Pfam PF00023 Ankyrin repeat 93 122 5.3E-4 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 Pfam PF12796 Ankyrin repeats (3 copies) 133 214 8.2E-13 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 PANTHER PTHR24188 28 209 1.2E-39 T 21-04-2016 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 Gene3D G3DSA:1.25.40.20 4 214 1.6E-46 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 SMART SM00248 35 64 0.47 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 SMART SM00248 1 30 2800.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 SMART SM00248 93 122 8.3E-5 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 SMART SM00248 128 157 0.017 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 SMART SM00248 161 190 2.4E-4 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 SUPERFAMILY SSF48403 3 214 4.39E-44 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 PRINTS PR01415 Ankyrin repeat signature 144 158 6.0E-5 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12615 1c863cd1bb8f5d2de48c9160a6ac0b12 215 PRINTS PR01415 Ankyrin repeat signature 94 109 6.0E-5 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 SMART SM00028 138 171 73.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 SMART SM00028 206 239 96.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 SMART SM00028 274 307 3.7E-4 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 Gene3D G3DSA:1.25.40.10 138 368 1.3E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 PANTHER PTHR23083 55 88 3.6E-25 T 21-04-2016 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 PANTHER PTHR23083 151 365 3.6E-25 T 21-04-2016 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 Pfam PF13181 Tetratricopeptide repeat 276 307 2.9E-6 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 Pfam PF13432 Tetratricopeptide repeat 210 271 0.014 T 21-04-2016 SPH21_RS16740 585efe6d672b0a2b0cf4da54b1f8ca46 382 SUPERFAMILY SSF48452 138 309 2.17E-21 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26075 1fe6311e6b18ec9b9ef2e5dd3de8dd23 333 PANTHER PTHR34220:SF1 107 331 1.3E-47 T 21-04-2016 SPH21_RS26075 1fe6311e6b18ec9b9ef2e5dd3de8dd23 333 Pfam PF06580 Histidine kinase 150 226 4.0E-20 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS26075 1fe6311e6b18ec9b9ef2e5dd3de8dd23 333 PANTHER PTHR34220 107 331 1.3E-47 T 21-04-2016 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 Gene3D G3DSA:3.10.20.80 13 86 2.2E-32 T 21-04-2016 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 Hamap MF_00080 Translation initiation factor IF-3 [infC]. 9 179 25.792 T 21-04-2016 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 Pfam PF00707 Translation initiation factor IF-3, C-terminal domain 93 177 8.4E-30 T 21-04-2016 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 Pfam PF05198 Translation initiation factor IF-3, N-terminal domain 17 84 1.9E-28 T 21-04-2016 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 PANTHER PTHR10938 9 182 1.3E-55 T 21-04-2016 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 SUPERFAMILY SSF54364 14 86 1.7E-24 T 21-04-2016 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 ProSitePatterns PS00938 Initiation factor 3 signature. 67 80 - T 21-04-2016 IPR019813 Translation initiation factor 3, conserved site GO:0003743|GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 TIGRFAM TIGR00168 infC: translation initiation factor IF-3 17 178 4.5E-52 T 21-04-2016 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 Gene3D G3DSA:3.30.110.10 89 179 8.4E-31 T 21-04-2016 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 SPH21_RS14755 dc23ecac72a8a8f0b4b60bce692e5a0a 182 SUPERFAMILY SSF55200 92 179 3.14E-27 T 21-04-2016 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 PANTHER PTHR10108 16 244 8.7E-74 T 21-04-2016 SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 TIGRFAM TIGR01934 MenG_MenH_UbiE: ubiquinone/menaquinone biosynthesis methyltransferase 20 244 1.3E-78 T 21-04-2016 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|UniPathway: UPA00079 SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 ProSitePatterns PS01184 ubiE/COQ5 methyltransferase family signature 2. 152 166 - T 21-04-2016 IPR023576 UbiE/COQ5 methyltransferase, conserved site GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|UniPathway: UPA00079 SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 SUPERFAMILY SSF53335 6 233 3.04E-45 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 Gene3D G3DSA:3.40.50.150 18 239 3.6E-49 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 ProSitePatterns PS01183 ubiE/COQ5 methyltransferase family signature 1. 31 46 - T 21-04-2016 IPR023576 UbiE/COQ5 methyltransferase, conserved site GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|UniPathway: UPA00079 SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 Hamap MF_01813 Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE [ubiE]. 11 244 35.167 T 21-04-2016 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|UniPathway: UPA00079 SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 Pfam PF01209 ubiE/COQ5 methyltransferase family 15 244 7.7E-68 T 21-04-2016 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|UniPathway: UPA00079 SPH21_RS25650 aca8aaad54cb31a019b504df257861be 244 PANTHER PTHR10108:SF24 16 244 8.7E-74 T 21-04-2016 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 Gene3D G3DSA:3.65.10.10 220 412 1.4E-47 T 21-04-2016 IPR001986 Enolpyruvate transferase domain GO:0016765 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 PIRSF PIRSF000505 3 415 7.2E-113 T 21-04-2016 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 Gene3D G3DSA:3.65.10.10 25 219 3.3E-49 T 21-04-2016 IPR001986 Enolpyruvate transferase domain GO:0016765 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 PANTHER PTHR21090:SF5 11 412 3.5E-106 T 21-04-2016 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 SUPERFAMILY SSF55205 9 412 1.27E-90 T 21-04-2016 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 PANTHER PTHR21090 11 412 3.5E-106 T 21-04-2016 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 TIGRFAM TIGR01356 aroA: 3-phosphoshikimate 1-carboxyvinyltransferase 17 411 1.5E-89 T 21-04-2016 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 Hamap MF_00210 3-phosphoshikimate 1-carboxyvinyltransferase [aroA]. 13 413 25.24 T 21-04-2016 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 12 407 2.9E-82 T 21-04-2016 IPR001986 Enolpyruvate transferase domain GO:0016765 SPH21_RS16030 eebe82fdf0be0bb26081d773e8a6b484 415 ProSitePatterns PS00885 EPSP synthase signature 2. 323 341 - T 21-04-2016 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 SMART SM00354 4 77 2.6E-21 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 Pfam PF13377 Periplasmic binding protein-like domain 174 335 1.4E-26 T 21-04-2016 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 PANTHER PTHR30146 4 336 1.5E-92 T 21-04-2016 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 SUPERFAMILY SSF53822 67 336 1.1E-63 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 54 4.0E-11 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 SUPERFAMILY SSF47413 3 65 4.1E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 Gene3D G3DSA:3.40.50.2300 175 336 3.5E-44 T 21-04-2016 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 Gene3D G3DSA:3.40.50.2300 64 174 4.6E-44 T 21-04-2016 SPH21_RS03010 bab1624bf03282f8e867c9d56ea59dde 337 Gene3D G3DSA:1.10.260.40 5 63 8.5E-20 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS17170 eeb893b6a7f2223896651294ed36d72b 294 PANTHER PTHR12149 7 293 2.4E-79 T 21-04-2016 SPH21_RS17170 eeb893b6a7f2223896651294ed36d72b 294 PANTHER PTHR12149:SF8 7 293 2.4E-79 T 21-04-2016 SPH21_RS17170 eeb893b6a7f2223896651294ed36d72b 294 PIRSF PIRSF006221 8 294 1.9E-79 T 21-04-2016 IPR016477 Fructosamine/Ketosamine-3-kinase SPH21_RS17170 eeb893b6a7f2223896651294ed36d72b 294 SUPERFAMILY SSF56112 14 290 1.24E-45 T 21-04-2016 IPR011009 Protein kinase-like domain SPH21_RS17170 eeb893b6a7f2223896651294ed36d72b 294 Gene3D G3DSA:3.90.1200.10 110 272 3.2E-14 T 21-04-2016 SPH21_RS17170 eeb893b6a7f2223896651294ed36d72b 294 Pfam PF03881 Fructosamine kinase 10 293 2.3E-82 T 21-04-2016 IPR016477 Fructosamine/Ketosamine-3-kinase SPH21_RS10255 d2b45d9ebe1db4215e4605748043d4c2 351 Gene3D G3DSA:3.60.10.10 113 280 3.5E-7 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS10255 d2b45d9ebe1db4215e4605748043d4c2 351 SUPERFAMILY SSF56219 100 318 1.01E-29 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS10255 d2b45d9ebe1db4215e4605748043d4c2 351 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 107 311 1.7E-24 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS05480 2bec4972857b9b8e6c1d0a54fae9980d 123 SMART SM00448 4 118 2.6E-38 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05480 2bec4972857b9b8e6c1d0a54fae9980d 123 Pfam PF00072 Response regulator receiver domain 6 118 5.0E-30 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05480 2bec4972857b9b8e6c1d0a54fae9980d 123 Gene3D G3DSA:3.40.50.2300 4 122 2.9E-41 T 21-04-2016 SPH21_RS05480 2bec4972857b9b8e6c1d0a54fae9980d 123 PANTHER PTHR24423 5 123 1.8E-42 T 21-04-2016 SPH21_RS05480 2bec4972857b9b8e6c1d0a54fae9980d 123 SUPERFAMILY SSF52172 3 123 5.69E-41 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS21985 60ed0a261faa26f1c32bd4731fb70c1b 216 Pfam PF10067 Predicted membrane protein (DUF2306) 51 195 1.7E-43 T 21-04-2016 IPR018750 Protein of unknown function DUF2306, membrane SPH21_RS12305 ffe2608a8a221433aacf4db089279c55 449 PIRSF PIRSF004548 1 449 4.2E-132 T 21-04-2016 IPR010364 Uncharacterised protein family, inner membrane CreD SPH21_RS12305 ffe2608a8a221433aacf4db089279c55 449 Pfam PF06123 Inner membrane protein CreD 18 445 5.1E-151 T 21-04-2016 IPR010364 Uncharacterised protein family, inner membrane CreD SPH21_RS12305 ffe2608a8a221433aacf4db089279c55 449 PANTHER PTHR30092 2 445 1.8E-121 T 21-04-2016 SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 SUPERFAMILY SSF51269 275 340 7.69E-14 T 21-04-2016 IPR006190 Antifreeze-like/N-acetylneuraminic acid synthase C-terminal SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 Gene3D G3DSA:3.90.1210.10 284 340 2.2E-13 T 21-04-2016 IPR006190 Antifreeze-like/N-acetylneuraminic acid synthase C-terminal SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 PANTHER PTHR23416 2 292 1.2E-105 T 21-04-2016 SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 SMART SM00858 283 341 1.5E-7 T 21-04-2016 IPR013974 SAF domain SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 Gene3D G3DSA:3.20.20.70 2 263 1.2E-110 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 PANTHER PTHR23416:SF62 2 292 1.2E-105 T 21-04-2016 SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 TIGRFAM TIGR03569 NeuB_NnaB: N-acetylneuraminate synthase 5 329 2.3E-146 T 21-04-2016 IPR020007 N-acetylneuraminate synthase KEGG: 00520+2.5.1.101|KEGG: 00900+2.5.1.10|MetaCyc: PWY-5123|MetaCyc: PWY-6749|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7131|MetaCyc: PWY-7721|MetaCyc: PWY-7736 SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 Pfam PF08666 SAF domain 285 325 1.2E-4 T 21-04-2016 IPR013974 SAF domain SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 SUPERFAMILY SSF51569 3 293 9.11E-88 T 21-04-2016 SPH21_RS08980 fc93744c5d21ad27b3a0a76d0b4e63f5 341 Pfam PF03102 NeuB family 25 264 1.7E-102 T 21-04-2016 IPR013132 N-acetylneuraminic acid synthase, N-terminal GO:0016051 SPH21_RS13155 ca3492a73038ac28475761147d20cdeb 588 SUPERFAMILY SSF49899 399 581 2.3E-43 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS13155 ca3492a73038ac28475761147d20cdeb 588 Pfam PF04616 Glycosyl hydrolases family 43 72 362 7.4E-79 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS13155 ca3492a73038ac28475761147d20cdeb 588 Gene3D G3DSA:2.115.10.20 71 377 7.6E-82 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS13155 ca3492a73038ac28475761147d20cdeb 588 SUPERFAMILY SSF75005 70 378 4.0E-80 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS13155 ca3492a73038ac28475761147d20cdeb 588 PANTHER PTHR22925:SF11 73 580 1.5E-114 T 21-04-2016 SPH21_RS13155 ca3492a73038ac28475761147d20cdeb 588 PANTHER PTHR22925 73 580 1.5E-114 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS13155 ca3492a73038ac28475761147d20cdeb 588 Gene3D G3DSA:2.60.120.200 400 582 1.6E-48 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS25630 b36386c37a2733d3902dca91450a7391 253 PRINTS PR00111 Alpha/beta hydrolase fold signature 86 99 2.4E-7 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25630 b36386c37a2733d3902dca91450a7391 253 PRINTS PR00111 Alpha/beta hydrolase fold signature 194 208 2.4E-7 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25630 b36386c37a2733d3902dca91450a7391 253 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 2.4E-7 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25630 b36386c37a2733d3902dca91450a7391 253 Pfam PF00561 alpha/beta hydrolase fold 21 115 5.4E-12 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25630 b36386c37a2733d3902dca91450a7391 253 PANTHER PTHR10992 13 250 5.1E-45 T 21-04-2016 SPH21_RS25630 b36386c37a2733d3902dca91450a7391 253 Gene3D G3DSA:3.40.50.1820 8 250 1.3E-49 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS25630 b36386c37a2733d3902dca91450a7391 253 SUPERFAMILY SSF53474 11 250 1.74E-49 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04000 b81c04217a3e15144ddddd2d09412dec 274 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 18 260 2.5E-59 T 21-04-2016 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SPH21_RS04000 b81c04217a3e15144ddddd2d09412dec 274 SUPERFAMILY SSF53850 16 269 5.87E-67 T 21-04-2016 SPH21_RS04000 b81c04217a3e15144ddddd2d09412dec 274 Gene3D G3DSA:3.40.190.10 16 98 2.5E-14 T 21-04-2016 SPH21_RS04000 b81c04217a3e15144ddddd2d09412dec 274 PANTHER PTHR30177 17 264 1.9E-69 T 21-04-2016 SPH21_RS04000 b81c04217a3e15144ddddd2d09412dec 274 PANTHER PTHR30177:SF0 17 264 1.9E-69 T 21-04-2016 SPH21_RS04000 b81c04217a3e15144ddddd2d09412dec 274 Gene3D G3DSA:3.40.190.100 101 221 3.9E-34 T 21-04-2016 SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 PANTHER PTHR11680 2 422 3.6E-241 T 21-04-2016 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|UniPathway: UPA00193|UniPathway: UPA00288 SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 Gene3D G3DSA:3.40.640.10 29 290 2.1E-93 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 PIRSF PIRSF000412 1 423 1.1E-159 T 21-04-2016 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|UniPathway: UPA00193|UniPathway: UPA00288 SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 Pfam PF00464 Serine hydroxymethyltransferase 2 392 3.5E-167 T 21-04-2016 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|UniPathway: UPA00193|UniPathway: UPA00288 SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 Gene3D G3DSA:3.90.1150.10 291 423 4.3E-54 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 SUPERFAMILY SSF53383 2 422 7.09E-171 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 1 423 50.062 T 21-04-2016 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|UniPathway: UPA00193|UniPathway: UPA00288 SPH21_RS05580 238a767a2d2adc9db13c4b83de7d626f 423 ProSitePatterns PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 214 230 - T 21-04-2016 IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site GO:0004372|GO:0006544|GO:0006563|GO:0030170 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|UniPathway: UPA00193|UniPathway: UPA00288 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 Pfam PF00561 alpha/beta hydrolase fold 55 288 5.3E-25 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PANTHER PTHR10992 36 302 1.7E-55 T 21-04-2016 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PANTHER PTHR10992:SF771 36 302 1.7E-55 T 21-04-2016 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PRINTS PR00412 Epoxide hydrolase signature 277 299 5.3E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PRINTS PR00412 Epoxide hydrolase signature 80 95 5.3E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PRINTS PR00412 Epoxide hydrolase signature 60 78 5.3E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PRINTS PR00111 Alpha/beta hydrolase fold signature 80 95 5.7E-7 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PRINTS PR00111 Alpha/beta hydrolase fold signature 246 260 5.7E-7 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 PRINTS PR00111 Alpha/beta hydrolase fold signature 124 137 5.7E-7 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 SUPERFAMILY SSF53474 35 299 2.13E-55 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS23770 ae56d8a9d416f3bfb7639e49257d413d 302 Gene3D G3DSA:3.40.50.1820 35 301 3.4E-63 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 255 266 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 Gene3D G3DSA:1.10.1060.10 208 264 9.8E-9 T 21-04-2016 SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 PANTHER PTHR30176:SF2 2 439 8.0E-63 T 21-04-2016 SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 Pfam PF11614 IG-like fold at C-terminal of FixG, putative oxidoreductase 338 452 6.7E-13 T 21-04-2016 IPR032879 FixG, C-terminal immunoglobulin-like domain SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 Pfam PF13746 4Fe-4S dicluster domain 204 307 3.7E-35 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 PANTHER PTHR30176 2 439 8.0E-63 T 21-04-2016 SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 SUPERFAMILY SSF54862 174 314 6.78E-22 T 21-04-2016 SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 SUPERFAMILY SSF54862 88 110 6.78E-22 T 21-04-2016 SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 TIGRFAM TIGR02745 ccoG_rdxA_fixG: cytochrome c oxidase accessory protein CcoG 27 450 8.7E-121 T 21-04-2016 IPR014116 Cytochrome c oxidase cbb3 type, accessory protein FixG GO:0016021 SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 Gene3D G3DSA:2.60.40.10 339 452 2.8E-9 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 Gene3D G3DSA:3.30.70.20 265 300 1.7E-4 T 21-04-2016 SPH21_RS17565 4aee211da4cd1f6c70d889b0d53bdbf5 458 Pfam PF12801 4Fe-4S binding domain 79 115 5.9E-13 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS14165 6104c5883d8d72bb2a6a3ad32571a125 500 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III 408 477 3.2E-10 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS14165 6104c5883d8d72bb2a6a3ad32571a125 500 Gene3D G3DSA:1.10.760.10 400 491 2.9E-20 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS14165 6104c5883d8d72bb2a6a3ad32571a125 500 Gene3D G3DSA:2.120.10.30 41 383 4.8E-95 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS14165 6104c5883d8d72bb2a6a3ad32571a125 500 SUPERFAMILY SSF50952 33 363 2.35E-36 T 21-04-2016 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SPH21_RS14165 6104c5883d8d72bb2a6a3ad32571a125 500 PANTHER PTHR19328 43 311 1.7E-57 T 21-04-2016 SPH21_RS14165 6104c5883d8d72bb2a6a3ad32571a125 500 SUPERFAMILY SSF46626 396 478 1.55E-16 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS14165 6104c5883d8d72bb2a6a3ad32571a125 500 Pfam PF07995 Glucose / Sorbosone dehydrogenase 50 363 5.8E-80 T 21-04-2016 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Pfam PF07730 Histidine kinase 823 888 7.9E-9 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Gene3D G3DSA:2.120.10.30 277 343 4.3E-4 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 933 1027 2.5E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 PANTHER PTHR24421:SF20 524 1042 9.1E-22 T 21-04-2016 SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 SUPERFAMILY SSF63829 476 627 5.3E-6 T 21-04-2016 SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Gene3D G3DSA:3.30.565.10 928 1025 4.1E-12 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 SUPERFAMILY SSF63829 277 447 6.15E-8 T 21-04-2016 SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Pfam PF07494 Two component regulator propeller 41 64 4.2E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Pfam PF07494 Two component regulator propeller 321 343 0.0042 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Pfam PF07494 Two component regulator propeller 88 109 0.011 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Pfam PF07495 Y_Y_Y domain 723 783 7.0E-16 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Gene3D G3DSA:2.120.10.30 38 208 9.0E-12 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 SUPERFAMILY SSF63829 36 201 2.42E-13 T 21-04-2016 SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 SUPERFAMILY SSF55874 931 1026 6.42E-19 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 PANTHER PTHR24421 524 1042 9.1E-22 T 21-04-2016 SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 SMART SM00387 930 1029 1.8E-4 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23820 5d29293ca1aca8e3bce20bd131f854e4 1051 Gene3D G3DSA:2.120.10.30 404 627 3.1E-4 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 Gene3D G3DSA:3.20.20.80 160 581 5.0E-119 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 Pfam PF02806 Alpha amylase, C-terminal all-beta domain 642 698 9.0E-5 T 21-04-2016 IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: REACT_474 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 PANTHER PTHR10357:SF74 1 584 0.0 T 21-04-2016 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 PANTHER PTHR10357:SF74 613 704 0.0 T 21-04-2016 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 Gene3D G3DSA:2.60.40.1180 594 704 2.0E-30 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 SUPERFAMILY SSF51011 594 704 3.69E-25 T 21-04-2016 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 Pfam PF00128 Alpha amylase, catalytic domain 196 285 8.3E-10 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 Gene3D G3DSA:2.60.40.10 7 159 3.4E-59 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 TIGRFAM TIGR02100 glgX_debranch: glycogen debranching enzyme GlgX 8 703 0.0 T 21-04-2016 IPR011837 Glycogen debranching enzyme, GlgX type GO:0004133|GO:0004553|GO:0005980 UniPathway: UPA00165 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 14 101 9.3E-22 T 21-04-2016 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 PANTHER PTHR10357 1 584 0.0 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 PANTHER PTHR10357 613 704 0.0 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 SUPERFAMILY SSF51445 507 579 5.2E-131 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 SUPERFAMILY SSF51445 141 478 5.2E-131 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 SMART SM00642 166 573 2.0E-8 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS01540 1ec80d5a566d72d2256157f0534cea75 708 SUPERFAMILY SSF81296 7 155 1.98E-50 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 SUPERFAMILY SSF52540 5 166 1.72E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 PANTHER PTHR11649:SF5 1 432 3.7E-133 T 21-04-2016 IPR016484 GTP-binding protein EngA GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 Pfam PF14714 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal 351 431 1.2E-31 T 21-04-2016 IPR032859 GTPase Der, C-terminal KH-domain-like SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 PIRSF PIRSF006485 1 433 3.6E-164 T 21-04-2016 IPR016484 GTP-binding protein EngA GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 Pfam PF01926 50S ribosome-binding GTPase 5 120 1.1E-27 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 Pfam PF01926 50S ribosome-binding GTPase 176 293 5.5E-26 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 Gene3D G3DSA:3.30.300.20 356 433 8.6E-33 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 Gene3D G3DSA:3.40.50.300 4 168 1.6E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 Gene3D G3DSA:3.40.50.300 169 355 2.1E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 PANTHER PTHR11649 1 432 3.7E-133 T 21-04-2016 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 SUPERFAMILY SSF52540 138 432 7.77E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 73 91 9.4E-9 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 5 25 9.4E-9 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 TIGRFAM TIGR03594 GTPase_EngA: ribosome-associated GTPase EngA 4 431 1.0E-166 T 21-04-2016 IPR016484 GTP-binding protein EngA GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 5 157 2.8E-22 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 175 315 2.6E-26 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS01820 35415b473a599f748110c53a3208b4dc 433 Hamap MF_00195 GTPase Der [der]. 2 433 37.115 T 21-04-2016 IPR016484 GTP-binding protein EngA GO:0005525 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Gene3D G3DSA:2.60.120.360 777 893 1.2E-5 T 21-04-2016 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 SUPERFAMILY SSF49303 204 309 2.42E-14 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PANTHER PTHR10066:SF71 22 525 1.1E-145 T 21-04-2016 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PANTHER PTHR10066:SF71 542 653 1.1E-145 T 21-04-2016 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PANTHER PTHR10066 22 525 1.1E-145 T 21-04-2016 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PANTHER PTHR10066 542 653 1.1E-145 T 21-04-2016 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PRINTS PR00132 Glycosyl hydrolase family 2 signature 421 436 3.6E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PRINTS PR00132 Glycosyl hydrolase family 2 signature 326 340 3.6E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PRINTS PR00132 Glycosyl hydrolase family 2 signature 357 375 3.6E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 PRINTS PR00132 Glycosyl hydrolase family 2 signature 110 125 3.6E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Gene3D G3DSA:2.60.40.320 189 308 7.0E-27 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Pfam PF16355 Domain of unknown function (DUF4982) 626 689 1.1E-15 T 21-04-2016 IPR032311 Domain of unknown function DUF4982 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Pfam PF11721 Di-glucose binding within endoplasmic reticulum 720 897 5.2E-33 T 21-04-2016 IPR021720 Malectin SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 SUPERFAMILY SSF49785 14 194 7.05E-39 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 321 456 3.4E-12 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Pfam PF00703 Glycosyl hydrolases family 2 204 309 6.0E-17 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 62 193 2.2E-13 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Gene3D G3DSA:2.60.40.1560 610 691 3.5E-16 T 21-04-2016 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Gene3D G3DSA:2.60.120.260 15 188 2.7E-39 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 Gene3D G3DSA:3.20.20.80 309 602 3.4E-41 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11355 eb46b545af8361d37a747cd18e6c618b 1178 SUPERFAMILY SSF51445 307 602 8.44E-45 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS06865 f518d26c8e77d83cfe0be33ff1661bc8 201 Pfam PF13568 Outer membrane protein beta-barrel domain 26 180 5.7E-17 T 21-04-2016 IPR025665 Outer membrane protein beta-barrel domain SPH21_RS06865 f518d26c8e77d83cfe0be33ff1661bc8 201 SUPERFAMILY SSF56925 27 200 1.26E-6 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS05825 ee47976e1545457eecfb7df853b69998 498 Gene3D G3DSA:3.40.50.300 36 241 2.1E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05825 ee47976e1545457eecfb7df853b69998 498 PANTHER PTHR30267:SF3 4 468 2.0E-134 T 21-04-2016 SPH21_RS05825 ee47976e1545457eecfb7df853b69998 498 PANTHER PTHR30267 4 468 2.0E-134 T 21-04-2016 SPH21_RS05825 ee47976e1545457eecfb7df853b69998 498 Pfam PF00158 Sigma-54 interaction domain 165 223 3.5E-5 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS05825 ee47976e1545457eecfb7df853b69998 498 SUPERFAMILY SSF52540 37 87 9.87E-17 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05825 ee47976e1545457eecfb7df853b69998 498 SUPERFAMILY SSF52540 132 318 9.87E-17 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05655 8d13f26669a5d6f266e43653591c6d49 552 SUPERFAMILY SSF53649 27 224 2.18E-60 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS05655 8d13f26669a5d6f266e43653591c6d49 552 SUPERFAMILY SSF53649 270 533 2.18E-60 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS05655 8d13f26669a5d6f266e43653591c6d49 552 Gene3D G3DSA:3.40.720.10 6 210 1.3E-68 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS05655 8d13f26669a5d6f266e43653591c6d49 552 Gene3D G3DSA:3.40.720.10 269 390 1.3E-68 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS05655 8d13f26669a5d6f266e43653591c6d49 552 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 34 493 1.0E-59 T 21-04-2016 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SPH21_RS05655 8d13f26669a5d6f266e43653591c6d49 552 PIRSF PIRSF031924 6 552 3.4E-122 T 21-04-2016 IPR026263 Alkaline phosphatase, prokaryotic KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 260 302 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 SUPERFAMILY SSF46689 206 257 9.41E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 Gene3D G3DSA:1.10.10.60 205 259 8.7E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 PANTHER PTHR11019:SF61 157 304 2.8E-37 T 21-04-2016 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 Pfam PF12833 Helix-turn-helix domain 229 304 5.8E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 Gene3D G3DSA:1.10.10.60 260 304 2.6E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 SMART SM00342 223 305 5.3E-28 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 SUPERFAMILY SSF46689 259 304 1.25E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 PANTHER PTHR11019 157 304 2.8E-37 T 21-04-2016 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 275 290 1.59E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS16555 eccd69b1e5d626eb4e587a1d665e5064 305 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 290 305 1.59E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Gene3D G3DSA:2.170.130.10 198 312 7.6E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Gene3D G3DSA:2.60.40.1120 108 197 1.8E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Gene3D G3DSA:2.40.170.20 1079 1162 6.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Gene3D G3DSA:2.40.170.20 404 863 6.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Gene3D G3DSA:2.40.170.20 995 1026 6.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Gene3D G3DSA:2.40.170.20 895 896 6.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Pfam PF13715 CarboxypepD_reg-like domain 108 189 1.1E-11 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532 568 871 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532 894 924 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532 98 450 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532 957 1160 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 SUPERFAMILY SSF56935 514 863 1.42E-70 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 SUPERFAMILY SSF56935 986 1031 1.42E-70 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 SUPERFAMILY SSF56935 186 326 1.42E-70 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 SUPERFAMILY SSF56935 1080 1162 1.42E-70 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 SUPERFAMILY SSF56935 396 484 1.42E-70 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532:SF57 568 871 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532:SF57 894 924 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532:SF57 98 450 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 PANTHER PTHR11532:SF57 957 1160 1.6E-219 T 21-04-2016 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 SUPERFAMILY SSF49464 108 187 2.62E-11 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 278 308 8.1E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 Pfam PF07715 TonB-dependent Receptor Plug Domain 197 302 3.2E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23165 f71d19e447f47a1081ea621919b57698 1162 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 108 1162 3.0E-244 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS15090 d8e9cecc5d364fc3cb1b2153344b5bf5 195 Pfam PF16117 Domain of unknown function (DUF4833) 54 192 1.8E-51 T 21-04-2016 IPR032269 Domain of unknown function DUF4833 SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 PIRSF PIRSF006493 1 251 2.4E-85 T 21-04-2016 IPR009187 Non-homologous end joining protein Ku, prokaryotic type SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 TIGRFAM TIGR02772 Ku_bact: Ku protein 1 250 2.5E-83 T 21-04-2016 IPR009187 Non-homologous end joining protein Ku, prokaryotic type SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 PANTHER PTHR41251:SF1 1 250 1.3E-63 T 21-04-2016 SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 Hamap MF_01875 Non-homologous end joining protein Ku [ku]. 1 251 31.048 T 21-04-2016 IPR009187 Non-homologous end joining protein Ku, prokaryotic type SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 SMART SM00559 52 179 4.6E-21 T 21-04-2016 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: REACT_216|Reactome: REACT_6185 SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 SUPERFAMILY SSF100939 1 247 1.43E-49 T 21-04-2016 IPR016194 SPOC-like, C-terminal domain SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 Gene3D G3DSA:2.40.290.10 9 170 1.2E-14 T 21-04-2016 IPR016194 SPOC-like, C-terminal domain SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 PANTHER PTHR41251 1 250 1.3E-63 T 21-04-2016 SPH21_RS17065 53ca9adc049000b9a0229783b6c8a045 251 Pfam PF02735 Ku70/Ku80 beta-barrel domain 11 188 8.2E-39 T 21-04-2016 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: REACT_216|Reactome: REACT_6185 SPH21_RS19765 045d94945df713554c02f4db0d731687 309 Pfam PF08443 RimK-like ATP-grasp domain 98 285 4.7E-66 T 21-04-2016 IPR013651 ATP-grasp fold, RimK-type SPH21_RS19765 045d94945df713554c02f4db0d731687 309 TIGRFAM TIGR00768 rimK_fam: alpha-L-glutamate ligase, RimK family 2 284 1.1E-78 T 21-04-2016 IPR004666 Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX GO:0006464 SPH21_RS19765 045d94945df713554c02f4db0d731687 309 PANTHER PTHR21621:SF0 2 289 1.3E-112 T 21-04-2016 SPH21_RS19765 045d94945df713554c02f4db0d731687 309 Gene3D G3DSA:3.30.1490.20 102 171 1.2E-7 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS19765 045d94945df713554c02f4db0d731687 309 PANTHER PTHR21621 2 289 1.3E-112 T 21-04-2016 SPH21_RS19765 045d94945df713554c02f4db0d731687 309 Gene3D G3DSA:3.40.50.20 5 101 2.8E-18 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS19765 045d94945df713554c02f4db0d731687 309 SUPERFAMILY SSF56059 98 289 1.43E-47 T 21-04-2016 SPH21_RS19765 045d94945df713554c02f4db0d731687 309 Gene3D G3DSA:3.30.470.20 172 276 1.2E-36 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 3.2E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 131 139 3.2E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 3.2E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 SUPERFAMILY SSF51735 1 242 1.63E-59 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 1.4E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 1.4E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 1.4E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 1.4E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 1.4E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PANTHER PTHR24322 10 135 2.2E-54 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PANTHER PTHR24322 152 184 2.2E-54 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 Pfam PF00106 short chain dehydrogenase 6 192 8.8E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 Gene3D G3DSA:3.40.50.720 5 252 3.8E-63 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PANTHER PTHR24322:SF414 10 135 2.2E-54 T 21-04-2016 SPH21_RS21770 d2437dd4fe768f4e35a949ba1bb16a6f 280 PANTHER PTHR24322:SF414 152 184 2.2E-54 T 21-04-2016 SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 Gene3D G3DSA:3.40.50.720 5 256 9.5E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 PANTHER PTHR24322 163 196 1.7E-24 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 PANTHER PTHR24322 13 147 1.7E-24 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 PANTHER PTHR24322:SF317 163 196 1.7E-24 T 21-04-2016 IPR014358 Enoyl-[acyl-carrier-protein] reductase (NADH) GO:0004318|GO:0006633|GO:0055114 KEGG: 00061+1.3.1.9|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321|UniPathway: UPA00094 SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 PANTHER PTHR24322:SF317 13 147 1.7E-24 T 21-04-2016 IPR014358 Enoyl-[acyl-carrier-protein] reductase (NADH) GO:0004318|GO:0006633|GO:0055114 KEGG: 00061+1.3.1.9|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321|UniPathway: UPA00094 SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 PIRSF PIRSF000094 3 264 4.3E-47 T 21-04-2016 IPR014358 Enoyl-[acyl-carrier-protein] reductase (NADH) GO:0004318|GO:0006633|GO:0055114 KEGG: 00061+1.3.1.9|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321|UniPathway: UPA00094 SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 256 7.7E-57 T 21-04-2016 SPH21_RS01960 dc168a479be55a014e665e9f674d1ed1 272 SUPERFAMILY SSF51735 7 257 4.95E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423 856 1089 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423 39 105 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423 803 840 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423 448 540 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423 1109 1280 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:3.40.50.2300 1124 1249 4.0E-35 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07495 Y_Y_Y domain 744 806 9.5E-12 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SMART SM00342 1288 1371 1.9E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF12833 Helix-turn-helix domain 1294 1372 3.2E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SUPERFAMILY SSF47384 852 923 3.14E-6 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423:SF487 856 1089 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423:SF487 39 105 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423:SF487 803 840 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423:SF487 448 540 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PANTHER PTHR24423:SF487 1109 1280 6.2E-90 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SUPERFAMILY SSF63829 31 292 1.73E-18 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SUPERFAMILY SSF63829 326 348 1.73E-18 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:1.10.10.60 1269 1324 6.6E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF00072 Response regulator receiver domain 1128 1239 5.6E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SUPERFAMILY SSF63829 430 673 8.5E-20 T 21-04-2016 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SMART SM00448 1126 1238 4.1E-32 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SUPERFAMILY SSF52172 1124 1247 5.55E-32 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1070 1083 8.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1046 1064 8.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1028 1038 8.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1010 1024 8.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:1.10.10.60 1325 1375 1.8E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:3.30.565.10 929 1088 1.5E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:2.120.10.30 564 681 1.2E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:2.120.10.30 433 536 7.1E-10 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:2.120.10.30 38 103 2.3E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Gene3D G3DSA:2.120.10.30 135 253 6.6E-12 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07494 Two component regulator propeller 605 627 0.013 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07494 Two component regulator propeller 419 441 0.014 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07494 Two component regulator propeller 173 195 1.7E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07494 Two component regulator propeller 224 243 0.0086 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07494 Two component regulator propeller 35 58 0.0017 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07494 Two component regulator propeller 80 102 0.016 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF07494 Two component regulator propeller 513 535 0.007 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SMART SM00387 973 1086 5.4E-28 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 974 1084 6.1E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SUPERFAMILY SSF55874 930 1084 6.55E-35 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09765 0d809e7ffa3f5e5d043575e59bff6970 1385 SUPERFAMILY SSF46689 1324 1377 3.09E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS15860 5c2b1399054e6424ab11bf1cb3d7b438 181 SUPERFAMILY SSF75217 11 175 2.42E-36 T 21-04-2016 IPR029028 Alpha/beta knot methyltransferases SPH21_RS15860 5c2b1399054e6424ab11bf1cb3d7b438 181 Pfam PF00588 SpoU rRNA Methylase family 25 168 5.3E-29 T 21-04-2016 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 SPH21_RS15860 5c2b1399054e6424ab11bf1cb3d7b438 181 PANTHER PTHR12029:SF60 1 176 1.5E-74 T 21-04-2016 SPH21_RS15860 5c2b1399054e6424ab11bf1cb3d7b438 181 PANTHER PTHR12029 1 176 1.5E-74 T 21-04-2016 SPH21_RS15860 5c2b1399054e6424ab11bf1cb3d7b438 181 Gene3D G3DSA:3.40.1280.10 21 175 2.5E-41 T 21-04-2016 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SPH21_RS21365 70c3eb31d16be9596825b3b9208d0087 207 SUPERFAMILY SSF52218 5 189 8.07E-39 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS21365 70c3eb31d16be9596825b3b9208d0087 207 Pfam PF02525 Flavodoxin-like fold 5 187 1.8E-33 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS21365 70c3eb31d16be9596825b3b9208d0087 207 Gene3D G3DSA:3.40.50.360 5 189 1.2E-44 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS21365 70c3eb31d16be9596825b3b9208d0087 207 PANTHER PTHR10204:SF16 5 184 3.4E-33 T 21-04-2016 SPH21_RS21365 70c3eb31d16be9596825b3b9208d0087 207 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 5 201 24.083 T 21-04-2016 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 SPH21_RS21365 70c3eb31d16be9596825b3b9208d0087 207 PANTHER PTHR10204 5 184 3.4E-33 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 Gene3D G3DSA:2.20.200.10 97 136 1.5E-10 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 Gene3D G3DSA:2.20.200.10 308 342 1.5E-10 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 PANTHER PTHR30203:SF14 8 476 2.1E-112 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 Pfam PF02321 Outer membrane efflux protein 276 457 4.8E-18 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 Pfam PF02321 Outer membrane efflux protein 65 249 1.3E-15 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 SUPERFAMILY SSF56954 2 461 1.27E-80 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 TIGRFAM TIGR01845 outer_NodT: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family 14 459 1.2E-78 T 21-04-2016 IPR010131 RND efflux system, outer membrane lipoprotein, NodT GO:0005215|GO:0006810|GO:0008289|GO:0016020 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 Gene3D G3DSA:1.20.1600.10 137 307 1.7E-82 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 Gene3D G3DSA:1.20.1600.10 345 459 1.7E-82 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 Gene3D G3DSA:1.20.1600.10 50 87 1.7E-82 T 21-04-2016 SPH21_RS12885 e6eead7cd06ffe8d76686418b977c58a 476 PANTHER PTHR30203 8 476 2.1E-112 T 21-04-2016 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 PANTHER PTHR30146 4 335 1.5E-89 T 21-04-2016 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 Gene3D G3DSA:3.40.50.2300 174 335 4.9E-41 T 21-04-2016 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 SUPERFAMILY SSF47413 3 62 1.59E-14 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 Gene3D G3DSA:1.10.260.40 5 61 5.7E-19 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 Pfam PF00532 Periplasmic binding proteins and sugar binding domain of LacI family 64 314 1.9E-25 T 21-04-2016 IPR001761 Periplasmic binding protein/LacI sugar binding domain SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 51 1.5E-11 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 SUPERFAMILY SSF53822 61 324 1.85E-58 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 ProSitePatterns PS00717 Sigma-54 factors family signature 1. 4 23 - T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 Gene3D G3DSA:3.40.50.2300 62 173 2.8E-40 T 21-04-2016 SPH21_RS14315 8e35c4a8aaccad9bf4bab03e2402dc27 341 SMART SM00354 4 74 1.2E-20 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 Pfam PF13899 Thioredoxin-like 398 460 4.3E-12 T 21-04-2016 SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 SUPERFAMILY SSF52833 394 534 8.2E-31 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 SUPERFAMILY SSF52833 337 356 8.2E-31 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 Pfam PF02683 Cytochrome C biogenesis protein transmembrane region 68 261 1.3E-13 T 21-04-2016 IPR003834 Cytochrome C biogenesis protein, transmembrane domain GO:0016020|GO:0017004|GO:0055114 SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 PANTHER PTHR32234 400 460 5.2E-97 T 21-04-2016 SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 PANTHER PTHR32234 59 368 5.2E-97 T 21-04-2016 SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 PANTHER PTHR32234:SF0 400 460 5.2E-97 T 21-04-2016 IPR022910 Thiol:disulphide interchange protein DsbD GO:0047134|GO:0055114 SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 PANTHER PTHR32234:SF0 59 368 5.2E-97 T 21-04-2016 IPR022910 Thiol:disulphide interchange protein DsbD GO:0047134|GO:0055114 SPH21_RS05210 53ab272007506033508885e1c7ad6950 538 Gene3D G3DSA:3.40.30.10 397 536 4.6E-44 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS20815 cc2c52e6f1c3b8686faf5cccf3889dd1 195 Pfam PF00027 Cyclic nucleotide-binding domain 29 113 7.3E-10 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS20815 cc2c52e6f1c3b8686faf5cccf3889dd1 195 SUPERFAMILY SSF51206 5 138 9.69E-21 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS20815 cc2c52e6f1c3b8686faf5cccf3889dd1 195 PANTHER PTHR24567:SF33 10 195 2.9E-25 T 21-04-2016 SPH21_RS20815 cc2c52e6f1c3b8686faf5cccf3889dd1 195 Gene3D G3DSA:2.60.120.10 1 155 1.7E-34 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS20815 cc2c52e6f1c3b8686faf5cccf3889dd1 195 PANTHER PTHR24567 10 195 2.9E-25 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:3.30.565.10 889 1048 7.2E-39 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SMART SM00388 820 886 0.004 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SMART SM00387 932 1045 1.8E-28 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF00072 Response regulator receiver domain 1085 1192 3.7E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF07495 Y_Y_Y domain 702 765 1.1E-14 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF52172 1082 1208 1.99E-30 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SMART SM00342 1244 1326 1.4E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF12833 Helix-turn-helix domain 1250 1326 8.4E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:1.10.287.130 814 881 8.0E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SMART SM00448 1082 1194 3.4E-28 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423 798 1236 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423 525 638 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423 35 140 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423 484 503 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:3.40.50.2300 1080 1204 3.0E-34 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF07494 Two component regulator propeller 387 408 0.014 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF07494 Two component regulator propeller 34 56 2.4E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF07494 Two component regulator propeller 567 589 0.0048 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF07494 Two component regulator propeller 477 498 0.0017 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF07494 Two component regulator propeller 434 456 5.5E-6 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:1.10.10.60 1279 1327 2.9E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 1281 1322 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:2.120.10.30 227 309 1.3E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423:SF486 798 1236 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423:SF486 525 638 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423:SF486 35 140 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PANTHER PTHR24423:SF486 484 503 6.7E-93 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF63829 535 694 7.85E-8 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF47384 811 886 4.71E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:2.120.10.30 415 513 3.6E-11 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:2.120.10.30 310 414 6.3E-7 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Gene3D G3DSA:2.120.10.30 537 692 3.2E-10 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF55874 876 1043 2.49E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF63829 356 558 9.81E-22 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF63829 36 138 6.21E-10 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF63829 173 240 6.21E-10 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF46689 1280 1327 3.63E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 933 1043 4.0E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 SUPERFAMILY SSF63829 222 425 3.01E-16 T 21-04-2016 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1005 1023 1.4E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PRINTS PR00344 Bacterial sensor protein C-terminal signature 990 1000 1.4E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PRINTS PR00344 Bacterial sensor protein C-terminal signature 972 986 1.4E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS24930 de00bcf81a234f9631cbb5a84c6f2ee8 1335 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1029 1042 1.4E-11 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 Pfam PF00704 Glycosyl hydrolases family 18 28 346 1.1E-67 T 21-04-2016 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 PANTHER PTHR11177 1 360 7.3E-77 T 21-04-2016 SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 SUPERFAMILY SSF54556 254 316 8.25E-10 T 21-04-2016 IPR029070 Chitinase insertion domain SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 Gene3D G3DSA:3.10.50.10 256 316 1.1E-10 T 21-04-2016 IPR029070 Chitinase insertion domain SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 SMART SM00636 26 346 3.1E-75 T 21-04-2016 IPR011583 Chitinase II GO:0004568|GO:0006032 SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 SUPERFAMILY SSF51445 23 254 1.44E-69 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 SUPERFAMILY SSF51445 318 350 1.44E-69 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 Gene3D G3DSA:3.20.20.80 6 255 5.1E-75 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS13385 d743f57d2a6ca4873bf78c08a301f97e 362 Gene3D G3DSA:3.20.20.80 323 358 5.1E-75 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:3.40.50.300 167 317 4.2E-115 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:3.40.50.300 103 121 4.2E-115 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:3.40.50.300 550 596 4.2E-115 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:3.40.50.300 3 61 4.2E-115 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF81886 772 900 1.57E-59 T 21-04-2016 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF81886 1075 1087 1.57E-59 T 21-04-2016 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF81886 947 1030 1.57E-59 T 21-04-2016 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 ProSitePatterns PS01312 SecA family signature. 681 696 - T 21-04-2016 IPR020937 SecA conserved site GO:0006605|GO:0006886|GO:0016020 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:1.10.3060.10 941 1020 9.1E-44 T 21-04-2016 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:1.10.3060.10 800 898 9.1E-44 T 21-04-2016 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Pfam PF00271 Helicase conserved C-terminal domain 614 730 6.7E-5 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Pfam PF01043 SecA preprotein cross-linking domain 398 539 6.6E-37 T 21-04-2016 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SMART SM00958 410 539 4.6E-31 T 21-04-2016 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Pfam PF07517 SecA DEAD-like domain 6 583 4.6E-121 T 21-04-2016 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PRINTS PR00906 SecA protein signature 557 574 1.1E-32 T 21-04-2016 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PRINTS PR00906 SecA protein signature 106 130 1.1E-32 T 21-04-2016 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PRINTS PR00906 SecA protein signature 594 607 1.1E-32 T 21-04-2016 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PRINTS PR00906 SecA protein signature 520 542 1.1E-32 T 21-04-2016 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:3.40.50.300 598 771 6.1E-82 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SMART SM00957 5 583 5.2E-235 T 21-04-2016 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SMART SM00490 644 731 0.0063 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:3.90.1440.10 481 548 3.1E-40 T 21-04-2016 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Gene3D G3DSA:3.90.1440.10 403 448 3.1E-40 T 21-04-2016 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Pfam PF07516 SecA Wing and Scaffold domain 770 1018 5.7E-57 T 21-04-2016 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF52540 598 770 2.73E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF52540 146 317 4.03E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 TIGRFAM TIGR00963 secA: preprotein translocase, SecA subunit 73 697 1.3E-194 T 21-04-2016 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Hamap MF_01382 Protein translocase subunit SecA [secA]. 4 1022 19.577 T 21-04-2016 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 Pfam PF02810 SEC-C motif 1079 1096 8.5E-11 T 21-04-2016 IPR004027 SEC-C motif SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PANTHER PTHR30612 1 64 0.0 T 21-04-2016 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PANTHER PTHR30612 168 354 0.0 T 21-04-2016 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PANTHER PTHR30612 466 1100 0.0 T 21-04-2016 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 PANTHER PTHR30612 108 122 0.0 T 21-04-2016 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF52540 4 56 4.03E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF52540 549 596 4.03E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF81767 404 450 3.79E-31 T 21-04-2016 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SPH21_RS03345 4c722bbac7d44d8524d2650c99fb6a82 1100 SUPERFAMILY SSF81767 483 548 3.79E-31 T 21-04-2016 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 Gene3D G3DSA:3.10.580.10 195 317 2.4E-32 T 21-04-2016 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 SMART SM00116 213 256 1.3 T 21-04-2016 IPR000644 CBS domain SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 SMART SM00116 273 320 8.7 T 21-04-2016 IPR000644 CBS domain SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 Pfam PF01380 SIS domain 44 171 1.6E-29 T 21-04-2016 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 Reactome: REACT_17015 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 Pfam PF00571 CBS domain 267 317 1.5E-6 T 21-04-2016 IPR000644 CBS domain SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 Pfam PF00571 CBS domain 212 255 1.0E-5 T 21-04-2016 IPR000644 CBS domain SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 TIGRFAM TIGR00393 kpsF: sugar isomerase, KpsF/GutQ family 45 311 1.2E-97 T 21-04-2016 IPR004800 Phosphosugar isomerase, KdsD/KpsF-type GO:0005975|GO:0016853 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 SUPERFAMILY SSF53697 8 316 1.42E-60 T 21-04-2016 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 PANTHER PTHR38418 5 209 8.7E-41 T 21-04-2016 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 Gene3D G3DSA:3.40.50.10490 15 194 1.3E-45 T 21-04-2016 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 PIRSF PIRSF004692 1 321 7.7E-123 T 21-04-2016 IPR004800 Phosphosugar isomerase, KdsD/KpsF-type GO:0005975|GO:0016853 SPH21_RS16750 6631b8c999219e2acc683a2515c3b3db 321 PANTHER PTHR38418:SF1 5 209 8.7E-41 T 21-04-2016 SPH21_RS07215 b9e0967deb741517c96b93bccb78b8be 564 Pfam PF00474 Sodium:solute symporter family 389 518 1.1E-11 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS07215 b9e0967deb741517c96b93bccb78b8be 564 Pfam PF00474 Sodium:solute symporter family 33 296 3.6E-23 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS07215 b9e0967deb741517c96b93bccb78b8be 564 Gene3D G3DSA:1.20.58.220 317 389 1.3E-4 T 21-04-2016 SPH21_RS07215 b9e0967deb741517c96b93bccb78b8be 564 PANTHER PTHR11819 2 297 2.6E-94 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS07215 b9e0967deb741517c96b93bccb78b8be 564 PANTHER PTHR11819 375 554 2.6E-94 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 PANTHER PTHR21368 1 147 3.2E-41 T 21-04-2016 IPR000244 Ribosomal protein L9 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 Gene3D G3DSA:3.40.5.10 1 49 1.2E-23 T 21-04-2016 IPR020070 Ribosomal protein L9, N-terminal SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 SUPERFAMILY SSF55653 59 147 2.22E-23 T 21-04-2016 IPR020069 Ribosomal protein L9, C-terminal SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 SUPERFAMILY SSF55658 1 56 2.44E-17 T 21-04-2016 IPR009027 Ribosomal protein L9/RNase H1, N-terminal SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 Pfam PF01281 Ribosomal protein L9, N-terminal domain 1 46 1.3E-22 T 21-04-2016 IPR020070 Ribosomal protein L9, N-terminal SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 Hamap MF_00503 50S ribosomal protein L9 [rplI]. 1 147 23.243 T 21-04-2016 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 Gene3D G3DSA:3.10.430.100 61 147 5.9E-27 T 21-04-2016 IPR020069 Ribosomal protein L9, C-terminal SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 TIGRFAM TIGR00158 L9: ribosomal protein bL9 1 146 1.7E-37 T 21-04-2016 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11595 7529fc34f4d695b51b2bd3148ff05018 147 Pfam PF03948 Ribosomal protein L9, C-terminal domain 64 146 1.4E-25 T 21-04-2016 IPR020069 Ribosomal protein L9, C-terminal SPH21_RS22650 c6c56175e1cfef475a919e76e8e3c293 381 SUPERFAMILY SSF50939 44 380 6.17E-90 T 21-04-2016 IPR011040 Sialidases SPH21_RS22650 c6c56175e1cfef475a919e76e8e3c293 381 Pfam PF13088 BNR repeat-like domain 60 353 2.2E-36 T 21-04-2016 IPR011040 Sialidases SPH21_RS22650 c6c56175e1cfef475a919e76e8e3c293 381 PANTHER PTHR10628:SF5 26 377 5.3E-66 T 21-04-2016 SPH21_RS22650 c6c56175e1cfef475a919e76e8e3c293 381 PANTHER PTHR10628 26 377 5.3E-66 T 21-04-2016 IPR026856 Sialidase family GO:0004308 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS22650 c6c56175e1cfef475a919e76e8e3c293 381 Gene3D G3DSA:2.120.10.10 45 380 5.8E-86 T 21-04-2016 IPR011040 Sialidases SPH21_RS05035 8e38c9f9ef01b7e2eae73b9e4972f423 656 SMART SM00813 460 647 3.1E-44 T 21-04-2016 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55|UniPathway: UPA00667 SPH21_RS05035 8e38c9f9ef01b7e2eae73b9e4972f423 656 SUPERFAMILY SSF51445 192 544 1.25E-71 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS05035 8e38c9f9ef01b7e2eae73b9e4972f423 656 Pfam PF06964 Alpha-L-arabinofuranosidase C-terminal domain 460 647 2.4E-44 T 21-04-2016 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55|UniPathway: UPA00667 SPH21_RS05035 8e38c9f9ef01b7e2eae73b9e4972f423 656 Gene3D G3DSA:2.60.120.260 61 208 2.6E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS05035 8e38c9f9ef01b7e2eae73b9e4972f423 656 PANTHER PTHR31776:SF0 6 656 5.2E-211 T 21-04-2016 SPH21_RS05035 8e38c9f9ef01b7e2eae73b9e4972f423 656 PANTHER PTHR31776 6 656 5.2E-211 T 21-04-2016 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 Gene3D G3DSA:1.10.10.60 238 285 1.2E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 Pfam PF12833 Helix-turn-helix domain 207 285 7.0E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 SUPERFAMILY SSF46689 237 285 8.51E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 SUPERFAMILY SSF46689 186 235 7.62E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 PANTHER PTHR11019:SF65 30 290 2.8E-29 T 21-04-2016 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 SUPERFAMILY SSF51182 19 76 4.58E-9 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 SMART SM00342 201 284 9.0E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 PANTHER PTHR11019 30 290 2.8E-29 T 21-04-2016 SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 Gene3D G3DSA:2.60.120.10 18 93 2.9E-13 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS04830 6735b10d51e4669c8e2e9ff1a49a9749 290 Gene3D G3DSA:1.10.10.60 186 237 2.4E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS17485 ecf28d6dca6630b36440c8b348884ce9 244 Hamap MF_00057 3-deoxy-manno-octulosonate cytidylyltransferase [kdsB]. 1 244 36.663 T 21-04-2016 IPR004528 3-deoxy-D-manno-octulosonate cytidylyltransferase GO:0005737|GO:0008690 KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|UniPathway: UPA00030|UniPathway: UPA00358 SPH21_RS17485 ecf28d6dca6630b36440c8b348884ce9 244 PANTHER PTHR21485:SF4 1 243 1.3E-104 T 21-04-2016 IPR004528 3-deoxy-D-manno-octulosonate cytidylyltransferase GO:0005737|GO:0008690 KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|UniPathway: UPA00030|UniPathway: UPA00358 SPH21_RS17485 ecf28d6dca6630b36440c8b348884ce9 244 PANTHER PTHR21485 1 243 1.3E-104 T 21-04-2016 SPH21_RS17485 ecf28d6dca6630b36440c8b348884ce9 244 SUPERFAMILY SSF53448 1 242 2.35E-51 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS17485 ecf28d6dca6630b36440c8b348884ce9 244 TIGRFAM TIGR00466 kdsB: 3-deoxy-D-manno-octulosonate cytidylyltransferase 2 237 2.5E-66 T 21-04-2016 IPR004528 3-deoxy-D-manno-octulosonate cytidylyltransferase GO:0005737|GO:0008690 KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|UniPathway: UPA00030|UniPathway: UPA00358 SPH21_RS17485 ecf28d6dca6630b36440c8b348884ce9 244 Pfam PF02348 Cytidylyltransferase 4 219 9.0E-54 T 21-04-2016 IPR003329 Acylneuraminate cytidylyltransferase KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|UniPathway: UPA00030|UniPathway: UPA00358 SPH21_RS17485 ecf28d6dca6630b36440c8b348884ce9 244 Gene3D G3DSA:3.90.550.10 1 243 2.3E-70 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Pfam PF16355 Domain of unknown function (DUF4982) 628 692 1.8E-21 T 21-04-2016 IPR032311 Domain of unknown function DUF4982 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Gene3D G3DSA:2.60.40.1560 615 708 4.8E-32 T 21-04-2016 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 309 526 2.1E-26 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Gene3D G3DSA:2.60.120.260 14 183 1.8E-45 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Pfam PF00703 Glycosyl hydrolases family 2 203 301 1.2E-11 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Gene3D G3DSA:2.60.40.920 709 760 2.3E-5 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 SUPERFAMILY SSF49373 706 748 8.11E-6 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Gene3D G3DSA:3.20.20.80 308 610 2.1E-78 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 SUPERFAMILY SSF49303 199 301 5.76E-15 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 SUPERFAMILY SSF51445 298 608 1.03E-75 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PANTHER PTHR10066 537 673 1.8E-257 T 21-04-2016 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PANTHER PTHR10066 5 510 1.8E-257 T 21-04-2016 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Gene3D G3DSA:2.60.40.320 184 302 8.1E-22 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PRINTS PR00132 Glycosyl hydrolase family 2 signature 313 327 2.0E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PRINTS PR00132 Glycosyl hydrolase family 2 signature 344 362 2.0E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PRINTS PR00132 Glycosyl hydrolase family 2 signature 125 140 2.0E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PRINTS PR00132 Glycosyl hydrolase family 2 signature 414 429 2.0E-10 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 32 190 4.6E-17 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PANTHER PTHR10066:SF71 537 673 1.8E-257 T 21-04-2016 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 PANTHER PTHR10066:SF71 5 510 1.8E-257 T 21-04-2016 SPH21_RS22560 3139daa5ad8396e8fc691eed910fdaff 811 SUPERFAMILY SSF49785 6 193 3.52E-44 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 Gene3D G3DSA:3.60.21.10 143 352 5.3E-40 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 PANTHER PTHR22953 43 342 1.4E-44 T 21-04-2016 SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 Gene3D G3DSA:2.60.40.380 45 141 7.4E-13 T 21-04-2016 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 SUPERFAMILY SSF49363 48 117 6.28E-11 T 21-04-2016 IPR008963 Purple acid phosphatase-like, N-terminal GO:0003993|GO:0046872 SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 Pfam PF16656 Purple acid Phosphatase, N-terminal domain 47 139 3.4E-10 T 21-04-2016 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 Pfam PF00149 Calcineurin-like phosphoesterase 150 342 2.9E-19 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 SUPERFAMILY SSF56300 149 366 7.99E-42 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS09495 21ab71f8b0b3a93b2347c1b821feb366 401 PANTHER PTHR22953:SF0 43 342 1.4E-44 T 21-04-2016 SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 SUPERFAMILY SSF51338 377 397 2.4E-15 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 SUPERFAMILY SSF51338 33 92 2.4E-15 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 PANTHER PTHR11647:SF71 18 132 9.9E-13 T 21-04-2016 SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 Gene3D G3DSA:2.30.40.10 32 149 1.2E-18 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 SUPERFAMILY SSF51556 125 378 1.09E-11 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 Gene3D G3DSA:2.30.40.10 316 404 5.8E-13 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 Pfam PF01979 Amidohydrolase family 318 390 4.7E-10 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS03825 2a40bf5c9b928f51917dffff4b673537 432 PANTHER PTHR11647 18 132 9.9E-13 T 21-04-2016 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Pfam PF01624 MutS domain I 9 119 2.2E-36 T 21-04-2016 IPR007695 DNA mismatch repair protein MutS-like, N-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 SUPERFAMILY SSF53150 115 268 1.83E-38 T 21-04-2016 IPR007860 DNA mismatch repair protein MutS, connector domain GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Pfam PF05188 MutS domain II 129 254 3.4E-18 T 21-04-2016 IPR007860 DNA mismatch repair protein MutS, connector domain GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Gene3D G3DSA:1.10.1420.10 265 469 1.6E-48 T 21-04-2016 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Pfam PF00488 MutS domain V 614 803 1.3E-82 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Pfam PF05190 MutS family domain IV 429 519 5.6E-26 T 21-04-2016 IPR007861 DNA mismatch repair protein MutS, clamp GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 SUPERFAMILY SSF55271 5 114 1.96E-37 T 21-04-2016 IPR016151 DNA mismatch repair protein MutS, N-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Gene3D G3DSA:3.40.1170.10 4 121 1.6E-44 T 21-04-2016 IPR016151 DNA mismatch repair protein MutS, N-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 PIRSF PIRSF037677 2 853 2.7E-164 T 21-04-2016 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Gene3D G3DSA:3.30.420.110 128 257 2.0E-35 T 21-04-2016 IPR007860 DNA mismatch repair protein MutS, connector domain GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Hamap MF_00096 DNA mismatch repair protein MutS [mutS]. 8 859 24.023 T 21-04-2016 IPR005748 DNA mismatch repair protein MutS, type 1 GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 PANTHER PTHR11361:SF86 2 863 0.0 T 21-04-2016 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Gene3D G3DSA:3.40.50.300 568 804 4.2E-84 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 PANTHER PTHR11361 2 863 0.0 T 21-04-2016 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 SMART SM00534 611 800 9.8E-111 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 SMART SM00533 284 592 5.5E-94 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 Pfam PF05192 MutS domain III 272 560 9.8E-36 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 SUPERFAMILY SSF48334 269 565 4.84E-79 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 SUPERFAMILY SSF52540 568 804 5.48E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 TIGRFAM TIGR01070 mutS1: DNA mismatch repair protein MutS 9 864 2.6E-278 T 21-04-2016 IPR005748 DNA mismatch repair protein MutS, type 1 GO:0005524|GO:0006298|GO:0030983 SPH21_RS15245 fdb79ba9a4d8276693b0e037fe209553 869 ProSitePatterns PS00486 DNA mismatch repair proteins mutS family signature. 692 708 - T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS16300 94e324a40af0116aef07967bae47457d 316 PANTHER PTHR12147 246 300 1.9E-44 T 21-04-2016 SPH21_RS16300 94e324a40af0116aef07967bae47457d 316 PANTHER PTHR12147 33 229 1.9E-44 T 21-04-2016 SPH21_RS16300 94e324a40af0116aef07967bae47457d 316 Pfam PF04389 Peptidase family M28 99 296 3.6E-44 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS16300 94e324a40af0116aef07967bae47457d 316 SUPERFAMILY SSF53187 32 302 5.74E-58 T 21-04-2016 SPH21_RS16300 94e324a40af0116aef07967bae47457d 316 Gene3D G3DSA:3.40.630.10 31 302 1.8E-61 T 21-04-2016 SPH21_RS16110 67715144bb386d2494b9ecaefb8a5a2c 160 Gene3D G3DSA:3.40.140.10 2 138 6.3E-47 T 21-04-2016 SPH21_RS16110 67715144bb386d2494b9ecaefb8a5a2c 160 PANTHER PTHR11079 1 160 4.8E-42 T 21-04-2016 SPH21_RS16110 67715144bb386d2494b9ecaefb8a5a2c 160 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 57 94 - T 21-04-2016 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 SPH21_RS16110 67715144bb386d2494b9ecaefb8a5a2c 160 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 8 105 2.6E-25 T 21-04-2016 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 SPH21_RS16110 67715144bb386d2494b9ecaefb8a5a2c 160 PANTHER PTHR11079:SF25 1 160 4.8E-42 T 21-04-2016 SPH21_RS16110 67715144bb386d2494b9ecaefb8a5a2c 160 SUPERFAMILY SSF53927 3 143 5.14E-45 T 21-04-2016 IPR016193 Cytidine deaminase-like GO:0003824 SPH21_RS16900 17dc21dfeb24ae78a75fc57336e7290e 285 Gene3D G3DSA:3.40.50.1580 23 283 2.5E-64 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS16900 17dc21dfeb24ae78a75fc57336e7290e 285 SUPERFAMILY SSF53167 15 283 8.62E-43 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS16900 17dc21dfeb24ae78a75fc57336e7290e 285 Pfam PF01048 Phosphorylase superfamily 29 261 1.3E-29 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS16900 17dc21dfeb24ae78a75fc57336e7290e 285 PANTHER PTHR21234 10 284 6.3E-46 T 21-04-2016 IPR018017 Nucleoside phosphorylase SPH21_RS16900 17dc21dfeb24ae78a75fc57336e7290e 285 PANTHER PTHR21234:SF8 10 284 6.3E-46 T 21-04-2016 SPH21_RS01070 37ca89785c1e26ad9a1d9e37d8ffb644 291 PANTHER PTHR30503 1 282 1.4E-62 T 21-04-2016 SPH21_RS01070 37ca89785c1e26ad9a1d9e37d8ffb644 291 Pfam PF05661 Protein of unknown function (DUF808) 3 250 9.4E-92 T 21-04-2016 IPR008526 Inner membrane protein YedI SPH21_RS01070 37ca89785c1e26ad9a1d9e37d8ffb644 291 PIRSF PIRSF016660 1 286 2.7E-91 T 21-04-2016 IPR008526 Inner membrane protein YedI SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 Gene3D G3DSA:3.40.50.300 85 342 3.1E-96 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 SUPERFAMILY SSF52540 87 325 2.49E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 PANTHER PTHR23264:SF19 1 356 5.0E-145 T 21-04-2016 SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 ProSitePatterns PS01215 Mrp family signature. 204 220 - T 21-04-2016 IPR000808 Mrp, conserved site GO:0005524 SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 PANTHER PTHR23264 1 356 5.0E-145 T 21-04-2016 IPR019591 Mrp/NBP35 ATP-binding protein SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 SUPERFAMILY SSF117916 1 86 5.89E-18 T 21-04-2016 SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 Pfam PF01883 Domain of unknown function DUF59 4 67 1.0E-14 T 21-04-2016 IPR002744 Domain of unknown function DUF59 SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 Hamap MF_02040 Iron-sulfur cluster carrier protein. 88 343 35.342 T 21-04-2016 IPR019591 Mrp/NBP35 ATP-binding protein SPH21_RS06720 f5320ae5c1a02591aa1ab3fc70453455 362 Pfam PF10609 NUBPL iron-transfer P-loop NTPase 92 342 8.0E-94 T 21-04-2016 IPR019591 Mrp/NBP35 ATP-binding protein SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Hamap MF_01322 DNA-directed RNA polymerase subunit beta' [rpoC]. 11 1415 10.204 T 21-04-2016 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Gene3D G3DSA:2.40.50.100 1155 1209 7.5E-11 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Pfam PF04983 RNA polymerase Rpb1, domain 3 503 657 3.5E-24 T 21-04-2016 IPR007066 RNA polymerase Rpb1, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Pfam PF00623 RNA polymerase Rpb1, domain 2 358 412 1.1E-9 T 21-04-2016 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Pfam PF00623 RNA polymerase Rpb1, domain 2 415 499 8.2E-26 T 21-04-2016 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Pfam PF05000 RNA polymerase Rpb1, domain 4 686 771 1.8E-15 T 21-04-2016 IPR007083 RNA polymerase Rpb1, domain 4 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 SUPERFAMILY SSF64484 1132 1291 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 SUPERFAMILY SSF64484 1333 1405 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 SUPERFAMILY SSF64484 11 952 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Pfam PF04998 RNA polymerase Rpb1, domain 5 774 1290 1.1E-66 T 21-04-2016 IPR007081 RNA polymerase Rpb1, domain 5 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 TIGRFAM TIGR02386 rpoC_TIGR: DNA-directed RNA polymerase, beta' subunit 16 1292 0.0 T 21-04-2016 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Pfam PF04997 RNA polymerase Rpb1, domain 1 11 356 2.0E-79 T 21-04-2016 IPR007080 RNA polymerase Rpb1, domain 1 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376 1 975 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376 1342 1402 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376 1175 1260 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376 999 1156 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376:SF32 1 975 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376:SF32 1342 1402 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376:SF32 1175 1260 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 PANTHER PTHR19376:SF32 999 1156 0.0 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 SMART SM00663 249 528 8.8E-170 T 21-04-2016 IPR006592 RNA polymerase, N-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Gene3D G3DSA:2.40.40.20 363 390 3.9E-37 T 21-04-2016 SPH21_RS11910 d6566512a07abeaeb3596762910d1aa8 1426 Gene3D G3DSA:2.40.40.20 431 502 3.9E-37 T 21-04-2016 SPH21_RS24450 eff119889e09053f77efeb8d4b27fbc4 225 SUPERFAMILY SSF46689 4 64 1.13E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24450 eff119889e09053f77efeb8d4b27fbc4 225 Gene3D G3DSA:1.10.357.10 5 168 3.9E-11 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS24450 eff119889e09053f77efeb8d4b27fbc4 225 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 61 3.5E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 Hamap MF_02128 Thiamine-monophosphate kinase [thiL]. 13 341 28.007 T 21-04-2016 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897|UniPathway: UPA00060 SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 Pfam PF02769 AIR synthase related protein, C-terminal domain 164 276 5.1E-5 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 PANTHER PTHR30270 1 345 5.1E-112 T 21-04-2016 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897|UniPathway: UPA00060 SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 PIRSF PIRSF005303 8 344 7.4E-98 T 21-04-2016 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897|UniPathway: UPA00060 SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 Pfam PF00586 AIR synthase related protein, N-terminal domain 39 150 4.6E-19 T 21-04-2016 IPR016188 PurM-like, N-terminal domain SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 SUPERFAMILY SSF56042 157 322 5.38E-33 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 Gene3D G3DSA:3.90.650.10 158 344 3.1E-46 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 Gene3D G3DSA:3.30.1330.10 10 153 4.7E-38 T 21-04-2016 IPR016188 PurM-like, N-terminal domain SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 PANTHER PTHR30270:SF0 1 345 5.1E-112 T 21-04-2016 SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 SUPERFAMILY SSF55326 12 151 2.62E-31 T 21-04-2016 SPH21_RS06375 c35c0cb98128243ad80ba9c945cfe1b8 345 TIGRFAM TIGR01379 thiL: thiamine-phosphate kinase 14 344 1.3E-90 T 21-04-2016 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897|UniPathway: UPA00060 SPH21_RS22785 43df056179283984a988052093f23cf3 293 SMART SM00342 203 284 3.5E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22785 43df056179283984a988052093f23cf3 293 SUPERFAMILY SSF46689 240 288 4.48E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22785 43df056179283984a988052093f23cf3 293 Gene3D G3DSA:1.10.10.60 239 286 1.3E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22785 43df056179283984a988052093f23cf3 293 PANTHER PTHR11019 133 292 1.3E-37 T 21-04-2016 SPH21_RS22785 43df056179283984a988052093f23cf3 293 PANTHER PTHR11019 15 114 1.3E-37 T 21-04-2016 SPH21_RS22785 43df056179283984a988052093f23cf3 293 Pfam PF12833 Helix-turn-helix domain 208 285 2.5E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22785 43df056179283984a988052093f23cf3 293 PANTHER PTHR11019:SF137 133 292 1.3E-37 T 21-04-2016 SPH21_RS22785 43df056179283984a988052093f23cf3 293 PANTHER PTHR11019:SF137 15 114 1.3E-37 T 21-04-2016 SPH21_RS21060 adf7ca63d5549425c8576b8bf47bee74 562 PANTHER PTHR30607 1 562 9.0E-268 T 21-04-2016 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SPH21_RS21060 adf7ca63d5549425c8576b8bf47bee74 562 Pfam PF03814 Potassium-transporting ATPase A subunit 10 559 1.3E-232 T 21-04-2016 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SPH21_RS21060 adf7ca63d5549425c8576b8bf47bee74 562 Hamap MF_00275 Potassium-transporting ATPase potassium-binding subunit [kdpA]. 1 561 31.177 T 21-04-2016 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SPH21_RS21060 adf7ca63d5549425c8576b8bf47bee74 562 PIRSF PIRSF001294 1 562 1.0E-220 T 21-04-2016 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SPH21_RS21060 adf7ca63d5549425c8576b8bf47bee74 562 TIGRFAM TIGR00680 kdpA: K+-transporting ATPase, A subunit 10 560 2.5E-184 T 21-04-2016 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856 303 690 0.0 T 21-04-2016 IPR015712 DNA-directed RNA polymerase, subunit 2 GO:0003899|GO:0006351|GO:0032549 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856:SF20 7 226 0.0 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856:SF20 1017 1269 0.0 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Pfam PF04560 RNA polymerase Rpb2, domain 7 1195 1268 4.6E-24 T 21-04-2016 IPR007641 RNA polymerase Rpb2, domain 7 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 TIGRFAM TIGR02013 rpoB: DNA-directed RNA polymerase, beta subunit 8 1267 0.0 T 21-04-2016 IPR010243 DNA-directed RNA polymerase, beta subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:3.90.1100.10 18 150 3.3E-137 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:3.90.1100.10 624 677 3.3E-137 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:3.90.1100.10 408 554 3.3E-137 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Pfam PF10385 RNA polymerase beta subunit external 1 domain 554 621 9.7E-22 T 21-04-2016 IPR019462 DNA-directed RNA polymerase, beta subunit, external 1 domain GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Pfam PF04563 RNA polymerase beta subunit 26 462 7.6E-24 T 21-04-2016 IPR007644 RNA polymerase, beta subunit, protrusion GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Hamap MF_01321 DNA-directed RNA polymerase subunit beta [rpoB]. 11 1269 11.971 T 21-04-2016 IPR010243 DNA-directed RNA polymerase, beta subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Pfam PF04565 RNA polymerase Rpb2, domain 3 476 544 4.7E-29 T 21-04-2016 IPR007645 RNA polymerase Rpb2, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856 711 898 0.0 T 21-04-2016 IPR015712 DNA-directed RNA polymerase, subunit 2 GO:0003899|GO:0006351|GO:0032549 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856 7 226 0.0 T 21-04-2016 IPR015712 DNA-directed RNA polymerase, subunit 2 GO:0003899|GO:0006351|GO:0032549 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856 1017 1269 0.0 T 21-04-2016 IPR015712 DNA-directed RNA polymerase, subunit 2 GO:0003899|GO:0006351|GO:0032549 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Pfam PF04561 RNA polymerase Rpb2, domain 2 150 222 4.3E-7 T 21-04-2016 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Pfam PF04561 RNA polymerase Rpb2, domain 2 309 417 1.1E-21 T 21-04-2016 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:2.40.50.100 680 760 4.7E-27 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:2.30.150.10 555 620 9.1E-20 T 21-04-2016 IPR019462 DNA-directed RNA polymerase, beta subunit, external 1 domain GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:2.40.270.10 761 788 2.3E-75 T 21-04-2016 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:2.40.270.10 1043 1171 2.3E-75 T 21-04-2016 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 ProSitePatterns PS01166 RNA polymerases beta chain signature. 1046 1058 - T 21-04-2016 IPR007121 RNA polymerase, beta subunit, conserved site GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856:SF20 303 690 0.0 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 PANTHER PTHR20856:SF20 711 898 0.0 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 SUPERFAMILY SSF64484 11 223 0.0 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 SUPERFAMILY SSF64484 1022 1268 0.0 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 SUPERFAMILY SSF64484 306 907 0.0 T 21-04-2016 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:2.40.50.150 1028 1042 1.0E-54 T 21-04-2016 IPR014724 RNA polymerase Rpb2, OB-fold GO:0003899 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:2.40.50.150 795 905 1.0E-54 T 21-04-2016 IPR014724 RNA polymerase Rpb2, OB-fold GO:0003899 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:3.90.1110.10 309 407 4.0E-60 T 21-04-2016 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Gene3D G3DSA:3.90.1110.10 152 227 4.0E-60 T 21-04-2016 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS11905 8c5e6493275a657f2d14bf11c61dda05 1269 Pfam PF00562 RNA polymerase Rpb2, domain 6 683 1193 4.0E-158 T 21-04-2016 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS04455 6014a01c92a32afa461306265505a25f 290 SUPERFAMILY SSF53474 8 287 3.42E-56 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04455 6014a01c92a32afa461306265505a25f 290 Pfam PF00561 alpha/beta hydrolase fold 28 148 6.1E-14 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS04455 6014a01c92a32afa461306265505a25f 290 PANTHER PTHR10992 1 287 1.9E-90 T 21-04-2016 SPH21_RS04455 6014a01c92a32afa461306265505a25f 290 Gene3D G3DSA:3.40.50.1820 4 287 6.0E-52 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04455 6014a01c92a32afa461306265505a25f 290 PRINTS PR00111 Alpha/beta hydrolase fold signature 53 68 9.6E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS04455 6014a01c92a32afa461306265505a25f 290 PRINTS PR00111 Alpha/beta hydrolase fold signature 114 127 9.6E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS04455 6014a01c92a32afa461306265505a25f 290 PANTHER PTHR10992:SF26 1 287 1.9E-90 T 21-04-2016 SPH21_RS08680 9d78cf17f25043eb07256103173da810 288 PANTHER PTHR22572 2 268 4.8E-159 T 21-04-2016 SPH21_RS08680 9d78cf17f25043eb07256103173da810 288 PANTHER PTHR22572:SF105 2 268 4.8E-159 T 21-04-2016 IPR005907 Glucose-1-phosphate thymidylyltransferase, short form GO:0008879|GO:0045226 KEGG: 00521+2.7.7.24|KEGG: 00523+2.7.7.24|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 SPH21_RS08680 9d78cf17f25043eb07256103173da810 288 TIGRFAM TIGR01207 rmlA: glucose-1-phosphate thymidylyltransferase 2 285 7.5E-143 T 21-04-2016 IPR005907 Glucose-1-phosphate thymidylyltransferase, short form GO:0008879|GO:0045226 KEGG: 00521+2.7.7.24|KEGG: 00523+2.7.7.24|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 SPH21_RS08680 9d78cf17f25043eb07256103173da810 288 SUPERFAMILY SSF53448 1 285 1.53E-90 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08680 9d78cf17f25043eb07256103173da810 288 Pfam PF00483 Nucleotidyl transferase 2 236 6.4E-69 T 21-04-2016 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 Reactome: REACT_17015 SPH21_RS08680 9d78cf17f25043eb07256103173da810 288 Gene3D G3DSA:3.90.550.10 1 262 1.6E-69 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS25635 1aece92d307a8825a7185443808ccd18 151 Pfam PF09424 Yqey-like protein 5 148 1.6E-45 T 21-04-2016 IPR019004 Uncharacterised domain YOR215C, mitochondrial SPH21_RS25635 1aece92d307a8825a7185443808ccd18 151 PANTHER PTHR28055:SF1 1 151 1.2E-45 T 21-04-2016 SPH21_RS25635 1aece92d307a8825a7185443808ccd18 151 Gene3D G3DSA:1.10.10.410 93 149 6.5E-23 T 21-04-2016 IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal SPH21_RS25635 1aece92d307a8825a7185443808ccd18 151 PANTHER PTHR28055 1 151 1.2E-45 T 21-04-2016 SPH21_RS25635 1aece92d307a8825a7185443808ccd18 151 SUPERFAMILY SSF89095 2 149 2.25E-37 T 21-04-2016 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-related GO:0016884 SPH21_RS25635 1aece92d307a8825a7185443808ccd18 151 Gene3D G3DSA:1.10.1510.10 1 92 2.2E-24 T 21-04-2016 SPH21_RS25435 b0068dffdc6b074d1d272530e3c82cad 124 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term 51 124 2.9E-22 T 21-04-2016 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SPH21_RS25435 b0068dffdc6b074d1d272530e3c82cad 124 SUPERFAMILY SSF54534 50 124 1.7E-18 T 21-04-2016 SPH21_RS25435 b0068dffdc6b074d1d272530e3c82cad 124 Gene3D G3DSA:3.10.50.30 47 124 1.5E-24 T 21-04-2016 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SPH21_RS25435 b0068dffdc6b074d1d272530e3c82cad 124 PANTHER PTHR30437 34 124 9.9E-23 T 21-04-2016 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 SMART SM00228 106 181 2.7E-7 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 TIGRFAM TIGR00225 prc: C-terminal processing peptidase 76 363 1.6E-77 T 21-04-2016 IPR004447 C-terminal-processing peptidase S41A GO:0006508|GO:0008236 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 SMART SM00245 183 365 7.7E-43 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 PANTHER PTHR32060:SF9 49 444 6.7E-115 T 21-04-2016 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 Gene3D G3DSA:2.30.42.10 109 191 9.2E-16 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 Pfam PF03572 Peptidase family S41 210 364 1.1E-48 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 SUPERFAMILY SSF52096 55 126 3.15E-62 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 SUPERFAMILY SSF52096 203 363 3.15E-62 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 Pfam PF13180 PDZ domain 110 189 7.1E-9 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 SUPERFAMILY SSF50156 81 207 1.08E-16 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 Gene3D G3DSA:3.90.226.10 192 362 1.3E-63 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 Gene3D G3DSA:3.90.226.10 415 427 1.3E-63 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 Gene3D G3DSA:3.90.226.10 519 538 1.3E-63 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS01855 a878332eae7af7f734df8faa08b19c2c 539 PANTHER PTHR32060 49 444 6.7E-115 T 21-04-2016 SPH21_RS10535 c0fc3fffbcd0b72fbf8289161b5ef842 344 SUPERFAMILY SSF51126 8 278 1.24E-22 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS10535 c0fc3fffbcd0b72fbf8289161b5ef842 344 Gene3D G3DSA:2.160.20.10 11 292 1.6E-21 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS10535 c0fc3fffbcd0b72fbf8289161b5ef842 344 Pfam PF13229 Right handed beta helix region 135 285 4.7E-6 T 21-04-2016 SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 SMART SM00357 3 63 7.9E-19 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 PIRSF PIRSF002599 1 63 3.2E-17 T 21-04-2016 IPR012156 Cold shock, CspA GO:0003676 SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 SUPERFAMILY SSF50249 1 62 3.64E-20 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 21-04-2016 IPR019844 Cold-shock conserved site SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 Pfam PF00313 'Cold-shock' DNA-binding domain 3 62 2.3E-21 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 PRINTS PR00050 Cold shock protein signature 36 54 9.0E-8 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 PRINTS PR00050 Cold shock protein signature 4 19 9.0E-8 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 Gene3D G3DSA:2.40.50.140 1 63 1.2E-24 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS23115 c45133aee4086df469ca5cea4d44ecb6 63 PANTHER PTHR11544 1 63 7.6E-19 T 21-04-2016 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 SUPERFAMILY SSF52518 8 356 1.2E-76 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 ProSitePatterns PS00802 Transketolase signature 2. 432 448 - T 21-04-2016 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Hamap MF_00315 1-deoxy-D-xylulose-5-phosphate synthase [dxs]. 8 633 43.41 T 21-04-2016 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 SUPERFAMILY SSF52922 500 630 1.57E-29 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Gene3D G3DSA:3.40.50.970 24 200 3.1E-75 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Gene3D G3DSA:3.40.50.970 246 341 3.1E-75 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Pfam PF02780 Transketolase, C-terminal domain 503 624 1.4E-25 T 21-04-2016 IPR033248 Transketolase, C-terminal domain SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 TIGRFAM TIGR00204 dxs: 1-deoxy-D-xylulose-5-phosphate synthase 10 625 9.3E-241 T 21-04-2016 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 PANTHER PTHR11624:SF20 22 217 3.4E-283 T 21-04-2016 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 PANTHER PTHR11624:SF20 245 642 3.4E-283 T 21-04-2016 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 ProSitePatterns PS00801 Transketolase signature 1. 34 53 - T 21-04-2016 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Pfam PF02779 Transketolase, pyrimidine binding domain 327 487 9.4E-39 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 SUPERFAMILY SSF52518 316 492 9.64E-59 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 PANTHER PTHR11624 22 217 3.4E-283 T 21-04-2016 IPR033247 Transketolase family SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 PANTHER PTHR11624 245 642 3.4E-283 T 21-04-2016 IPR033247 Transketolase family SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 SMART SM00861 326 491 1.4E-63 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Pfam PF13292 1-deoxy-D-xylulose-5-phosphate synthase 9 286 3.8E-117 T 21-04-2016 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Gene3D G3DSA:3.40.50.920 504 631 2.9E-37 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS05570 f3670cbf76f4683210f8561bdce081b4 642 Gene3D G3DSA:3.40.50.970 342 503 6.5E-39 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 310 340 1.4E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Pfam PF00593 TonB dependent receptor 732 1142 8.5E-16 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Gene3D G3DSA:2.40.170.20 1059 1073 1.6E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Gene3D G3DSA:2.40.170.20 966 1012 1.6E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Gene3D G3DSA:2.40.170.20 449 511 1.6E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Gene3D G3DSA:2.40.170.20 615 898 1.6E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Pfam PF07715 TonB-dependent Receptor Plug Domain 227 334 9.9E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Gene3D G3DSA:2.60.40.1120 135 221 5.2E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 PANTHER PTHR11532:SF57 122 546 4.5E-262 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 PANTHER PTHR11532:SF57 630 1141 4.5E-262 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Gene3D G3DSA:2.170.130.10 222 338 5.8E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 Pfam PF13715 CarboxypepD_reg-like domain 135 219 8.7E-14 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 SUPERFAMILY SSF56935 973 1017 2.15E-84 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 SUPERFAMILY SSF56935 215 358 2.15E-84 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 SUPERFAMILY SSF56935 547 900 2.15E-84 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 SUPERFAMILY SSF56935 422 510 2.15E-84 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 SUPERFAMILY SSF56935 1061 1143 2.15E-84 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 134 1143 1.5E-268 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 PANTHER PTHR11532 122 546 4.5E-262 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 PANTHER PTHR11532 630 1141 4.5E-262 T 21-04-2016 SPH21_RS21450 9b602248e9f679861386c5c9efc88ed6 1143 SUPERFAMILY SSF49464 133 217 2.49E-10 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 Gene3D G3DSA:3.20.20.80 28 358 1.2E-80 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 PANTHER PTHR10030:SF28 10 560 3.8E-162 T 21-04-2016 SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 Pfam PF00754 F5/8 type C domain 515 620 4.4E-14 T 21-04-2016 IPR000421 Coagulation factor 5/8 C-terminal domain SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 Pfam PF01120 Alpha-L-fucosidase 33 358 6.3E-33 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 Gene3D G3DSA:2.60.120.260 510 637 3.8E-22 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 Gene3D G3DSA:2.60.120.260 363 480 2.5E-7 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 SMART SM00812 53 408 2.7E-10 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 SUPERFAMILY SSF51445 29 358 6.13E-79 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 SUPERFAMILY SSF49785 363 480 5.17E-7 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 SUPERFAMILY SSF49785 513 635 6.17E-23 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS03265 1f9f38b9d8a44ee7f4978d672f9a77ed 640 PANTHER PTHR10030 10 560 3.8E-162 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 PANTHER PTHR37299 132 237 3.2E-19 T 21-04-2016 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 Gene3D G3DSA:3.40.50.2300 3 113 1.1E-11 T 21-04-2016 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 PANTHER PTHR37299:SF1 132 237 3.2E-19 T 21-04-2016 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 Pfam PF00072 Response regulator receiver domain 5 111 4.4E-9 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 SMART SM00448 3 111 1.4E-4 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 Pfam PF04397 LytTr DNA-binding domain 144 238 8.7E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 SMART SM00850 143 239 5.9E-26 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 Gene3D G3DSA:2.40.50.40 135 203 2.6E-19 T 21-04-2016 SPH21_RS15975 55169eb5bfdc531e2a31511ab5328b0d 239 SUPERFAMILY SSF52172 3 114 2.28E-15 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 Gene3D G3DSA:3.30.1300.10 176 282 3.4E-27 T 21-04-2016 SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 Pfam PF02569 Pantoate-beta-alanine ligase 3 280 4.7E-93 T 21-04-2016 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1|UniPathway: UPA00028 SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 TIGRFAM TIGR00018 panC: pantoate--beta-alanine ligase 2 282 1.3E-86 T 21-04-2016 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1|UniPathway: UPA00028 SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 PANTHER PTHR21299 2 282 7.3E-109 T 21-04-2016 SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 PANTHER PTHR21299:SF1 2 282 7.3E-109 T 21-04-2016 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1|UniPathway: UPA00028 SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 Gene3D G3DSA:3.40.50.620 2 174 1.1E-66 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 Hamap MF_00158 Pantothenate synthetase [panC]. 2 282 35.126 T 21-04-2016 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1|UniPathway: UPA00028 SPH21_RS08095 dff6a71f7be63b08380fad7807eeb580 283 SUPERFAMILY SSF52374 3 282 5.63E-93 T 21-04-2016 SPH21_RS24360 1b0525e5204c107e367a8416ab19ddfd 245 Gene3D G3DSA:3.40.50.300 64 224 1.5E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24360 1b0525e5204c107e367a8416ab19ddfd 245 SUPERFAMILY SSF52540 67 236 1.61E-19 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24360 1b0525e5204c107e367a8416ab19ddfd 245 PANTHER PTHR30050 9 239 4.8E-55 T 21-04-2016 SPH21_RS24360 1b0525e5204c107e367a8416ab19ddfd 245 Pfam PF01695 IstB-like ATP binding protein 53 230 1.7E-55 T 21-04-2016 IPR002611 IstB-like ATP-binding protein GO:0005524 SPH21_RS24360 1b0525e5204c107e367a8416ab19ddfd 245 PANTHER PTHR30050:SF6 9 239 4.8E-55 T 21-04-2016 SPH21_RS24360 1b0525e5204c107e367a8416ab19ddfd 245 PIRSF PIRSF003073 1 244 6.6E-66 T 21-04-2016 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SPH21_RS20285 1b0525e5204c107e367a8416ab19ddfd 245 Gene3D G3DSA:3.40.50.300 64 224 1.5E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20285 1b0525e5204c107e367a8416ab19ddfd 245 SUPERFAMILY SSF52540 67 236 1.61E-19 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20285 1b0525e5204c107e367a8416ab19ddfd 245 PANTHER PTHR30050 9 239 4.8E-55 T 21-04-2016 SPH21_RS20285 1b0525e5204c107e367a8416ab19ddfd 245 Pfam PF01695 IstB-like ATP binding protein 53 230 1.7E-55 T 21-04-2016 IPR002611 IstB-like ATP-binding protein GO:0005524 SPH21_RS20285 1b0525e5204c107e367a8416ab19ddfd 245 PANTHER PTHR30050:SF6 9 239 4.8E-55 T 21-04-2016 SPH21_RS20285 1b0525e5204c107e367a8416ab19ddfd 245 PIRSF PIRSF003073 1 244 6.6E-66 T 21-04-2016 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SPH21_RS04185 1b0525e5204c107e367a8416ab19ddfd 245 Gene3D G3DSA:3.40.50.300 64 224 1.5E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04185 1b0525e5204c107e367a8416ab19ddfd 245 SUPERFAMILY SSF52540 67 236 1.61E-19 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04185 1b0525e5204c107e367a8416ab19ddfd 245 PANTHER PTHR30050 9 239 4.8E-55 T 21-04-2016 SPH21_RS04185 1b0525e5204c107e367a8416ab19ddfd 245 Pfam PF01695 IstB-like ATP binding protein 53 230 1.7E-55 T 21-04-2016 IPR002611 IstB-like ATP-binding protein GO:0005524 SPH21_RS04185 1b0525e5204c107e367a8416ab19ddfd 245 PANTHER PTHR30050:SF6 9 239 4.8E-55 T 21-04-2016 SPH21_RS04185 1b0525e5204c107e367a8416ab19ddfd 245 PIRSF PIRSF003073 1 244 6.6E-66 T 21-04-2016 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069:SF11 553 825 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069:SF11 19 536 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069:SF11 847 887 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069:SF11 925 1015 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Pfam PF07715 TonB-dependent Receptor Plug Domain 117 241 8.9E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Gene3D G3DSA:2.60.40.1120 24 110 5.7E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Gene3D G3DSA:2.170.130.10 111 245 3.2E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Pfam PF13715 CarboxypepD_reg-like domain 25 108 3.0E-21 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 1015 1.6E-188 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 SUPERFAMILY SSF56935 837 879 6.41E-75 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 SUPERFAMILY SSF56935 300 389 6.41E-75 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 SUPERFAMILY SSF56935 105 265 6.41E-75 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 SUPERFAMILY SSF56935 926 1015 6.41E-75 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 SUPERFAMILY SSF56935 440 784 6.41E-75 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Gene3D G3DSA:2.40.170.20 447 782 1.6E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Gene3D G3DSA:2.40.170.20 837 870 1.6E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Gene3D G3DSA:2.40.170.20 311 379 1.6E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 Gene3D G3DSA:2.40.170.20 413 414 1.6E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069 553 825 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069 19 536 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069 847 887 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 PANTHER PTHR30069 925 1015 1.1E-206 T 21-04-2016 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 217 247 3.7E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS12105 49f962105db4368551a9e85a12a9c2a4 1015 SUPERFAMILY SSF49464 23 106 2.35E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02420 9ace39fd00d05f36b8cf3df086eb27fb 339 PANTHER PTHR30273 1 339 4.0E-62 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS02420 9ace39fd00d05f36b8cf3df086eb27fb 339 PANTHER PTHR30273:SF2 1 339 4.0E-62 T 21-04-2016 SPH21_RS02420 9ace39fd00d05f36b8cf3df086eb27fb 339 Pfam PF16344 Domain of unknown function (DUF4974) 250 336 6.0E-19 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS02420 9ace39fd00d05f36b8cf3df086eb27fb 339 Pfam PF04773 FecR protein 118 209 6.4E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS02420 9ace39fd00d05f36b8cf3df086eb27fb 339 PIRSF PIRSF018266 9 339 2.0E-51 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS10450 edc556760323c45fc6b1661cd58ccc3b 336 PANTHER PTHR12526:SF374 1 334 2.7E-42 T 21-04-2016 SPH21_RS10450 edc556760323c45fc6b1661cd58ccc3b 336 Pfam PF00534 Glycosyl transferases group 1 169 304 1.3E-22 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS10450 edc556760323c45fc6b1661cd58ccc3b 336 Pfam PF13439 Glycosyltransferase Family 4 22 159 7.1E-8 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS10450 edc556760323c45fc6b1661cd58ccc3b 336 Gene3D G3DSA:3.40.50.2000 170 304 4.5E-17 T 21-04-2016 SPH21_RS10450 edc556760323c45fc6b1661cd58ccc3b 336 PANTHER PTHR12526 1 334 2.7E-42 T 21-04-2016 SPH21_RS10450 edc556760323c45fc6b1661cd58ccc3b 336 SUPERFAMILY SSF53756 9 335 3.34E-57 T 21-04-2016 SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 Gene3D G3DSA:3.40.50.1220 212 373 6.0E-60 T 21-04-2016 IPR029035 DHS-like NAD/FAD-binding domain SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 SUPERFAMILY SSF52467 213 372 2.13E-57 T 21-04-2016 IPR029035 DHS-like NAD/FAD-binding domain SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 PANTHER PTHR18968:SF116 4 582 4.9E-271 T 21-04-2016 SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 SUPERFAMILY SSF52518 19 194 4.98E-60 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 Gene3D G3DSA:3.40.50.970 384 580 2.7E-67 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 412 559 5.8E-44 T 21-04-2016 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 216 349 4.2E-44 T 21-04-2016 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 Gene3D G3DSA:3.40.50.970 22 194 4.3E-68 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 SUPERFAMILY SSF52518 389 580 6.79E-64 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 449 468 - T 21-04-2016 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 25 191 2.1E-52 T 21-04-2016 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 TIGRFAM TIGR00118 acolac_lg: acetolactate synthase, large subunit, biosynthetic type 25 580 2.7E-210 T 21-04-2016 IPR012846 Acetolactate synthase, large subunit, biosynthetic GO:0000287|GO:0003984|GO:0009082|GO:0030976|GO:0050660 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11275 73d57401fb770177d0e5a67032735975 583 PANTHER PTHR18968 4 582 4.9E-271 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532:SF51 207 477 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532:SF51 603 1056 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532:SF51 547 574 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532:SF51 26 188 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532 207 477 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532 603 1056 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532 547 574 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 PANTHER PTHR11532 26 188 1.7E-191 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Gene3D G3DSA:2.40.170.20 347 416 4.0E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Gene3D G3DSA:2.40.170.20 482 825 4.0E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Gene3D G3DSA:2.40.170.20 240 278 4.0E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Gene3D G3DSA:2.40.170.20 875 923 4.0E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Gene3D G3DSA:2.40.170.20 956 1058 4.0E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 SUPERFAMILY SSF49464 25 101 2.35E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Pfam PF13715 CarboxypepD_reg-like domain 27 106 8.4E-18 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Gene3D G3DSA:2.60.40.1120 26 107 4.8E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 25 1058 1.4E-184 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Gene3D G3DSA:2.170.130.10 108 239 2.2E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 Pfam PF07715 TonB-dependent Receptor Plug Domain 115 239 8.7E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 216 245 6.8E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 SUPERFAMILY SSF56935 480 812 1.98E-68 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 SUPERFAMILY SSF56935 342 429 1.98E-68 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 SUPERFAMILY SSF56935 103 262 1.98E-68 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 SUPERFAMILY SSF56935 866 909 1.98E-68 T 21-04-2016 SPH21_RS17095 fa07032927230d08dbf3bf26947eb119 1058 SUPERFAMILY SSF56935 968 1058 1.98E-68 T 21-04-2016 SPH21_RS25085 e8a30a715520ae2f7f5c7cebf2bdcf20 254 SUPERFAMILY SSF48371 33 244 1.06E-37 T 21-04-2016 IPR016024 Armadillo-type fold GO:0005488 SPH21_RS25085 e8a30a715520ae2f7f5c7cebf2bdcf20 254 Pfam PF08713 DNA alkylation repair enzyme 129 242 1.1E-5 T 21-04-2016 IPR014825 DNA alkylation repair enzyme SPH21_RS25085 e8a30a715520ae2f7f5c7cebf2bdcf20 254 PANTHER PTHR39167 1 244 1.8E-65 T 21-04-2016 SPH21_RS25085 e8a30a715520ae2f7f5c7cebf2bdcf20 254 Gene3D G3DSA:1.25.40.290 141 244 7.4E-7 T 21-04-2016 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 Pfam PF03412 Peptidase C39 family 8 135 2.6E-28 T 21-04-2016 IPR005074 Peptidase C39, bacteriocin processing GO:0005524|GO:0006508|GO:0008233|GO:0016021 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 PANTHER PTHR24221:SF138 523 762 2.4E-162 T 21-04-2016 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 PANTHER PTHR24221:SF138 154 502 2.4E-162 T 21-04-2016 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 SUPERFAMILY SSF52540 520 760 8.3E-84 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 ProSitePatterns PS00211 ABC transporters family signature. 662 676 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 Gene3D G3DSA:3.40.50.300 523 755 9.1E-77 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 SMART SM00382 550 736 4.3E-18 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 Pfam PF00005 ABC transporter 541 690 6.8E-32 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 SUPERFAMILY SSF90123 168 480 4.05E-57 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 PANTHER PTHR24221 523 762 2.4E-162 T 21-04-2016 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 PANTHER PTHR24221 154 502 2.4E-162 T 21-04-2016 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 Gene3D G3DSA:3.90.70.10 15 136 1.5E-18 T 21-04-2016 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 Gene3D G3DSA:1.20.1560.10 169 478 4.8E-64 T 21-04-2016 SPH21_RS03450 de937ca23932c25e8056260ead13fedb 766 Pfam PF00664 ABC transporter transmembrane region 184 450 2.2E-27 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 SMART SM00850 148 248 1.4E-21 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 SUPERFAMILY SSF52172 1 116 4.27E-22 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 Pfam PF00072 Response regulator receiver domain 3 111 6.0E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 Pfam PF04397 LytTr DNA-binding domain 149 247 8.3E-17 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 SMART SM00448 1 111 3.8E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 Gene3D G3DSA:2.40.50.40 140 206 7.9E-12 T 21-04-2016 SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 Gene3D G3DSA:3.40.50.2300 1 115 6.7E-21 T 21-04-2016 SPH21_RS00645 1d51693ac3d386bf80510ac69dd19c9d 250 PANTHER PTHR26402 1 111 1.3E-19 T 21-04-2016 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 SUPERFAMILY SSF51984 10 102 1.96E-19 T 21-04-2016 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 Gene3D G3DSA:3.40.1190.10 104 312 6.8E-62 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 Pfam PF02875 Mur ligase family, glutamate ligase domain 311 397 3.0E-22 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 SUPERFAMILY SSF53623 102 309 5.63E-57 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 Gene3D G3DSA:3.40.50.720 12 102 3.4E-19 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 Pfam PF08245 Mur ligase middle domain 121 291 2.6E-23 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 PANTHER PTHR23135 4 442 1.1E-141 T 21-04-2016 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 SUPERFAMILY SSF53244 310 449 4.43E-37 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 TIGRFAM TIGR01082 murC: UDP-N-acetylmuramate--L-alanine ligase 12 443 3.2E-113 T 21-04-2016 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 Pfam PF01225 Mur ligase family, catalytic domain 15 115 2.0E-10 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 PANTHER PTHR23135:SF5 4 442 1.1E-141 T 21-04-2016 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 Hamap MF_00046 UDP-N-acetylmuramate--L-alanine ligase [murC]. 9 453 32.827 T 21-04-2016 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS00270 b0a6d721d495f12fe1e8cd89e2def661 454 Gene3D G3DSA:3.90.190.20 313 450 1.0E-40 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 PIRSF PIRSF006402 1 672 1.9E-226 T 21-04-2016 IPR024705 Spermatogenesis-associated protein 20 SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 PANTHER PTHR12145 2 667 2.3E-241 T 21-04-2016 SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 Pfam PF03190 Protein of unknown function, DUF255 3 156 3.8E-67 T 21-04-2016 IPR004879 Domain of unknown function DUF255 SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 Gene3D G3DSA:3.40.30.10 20 140 8.7E-33 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 Gene3D G3DSA:1.50.10.10 170 520 3.0E-20 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 SUPERFAMILY SSF52833 2 127 6.35E-33 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 PANTHER PTHR12145:SF11 2 667 2.3E-241 T 21-04-2016 SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 Pfam PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) 477 513 6.7E-4 T 21-04-2016 SPH21_RS17625 069fcc86a3ae9355b55aa4af9040c58b 672 SUPERFAMILY SSF48208 177 537 2.18E-69 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 Gene3D G3DSA:3.30.565.10 280 429 7.5E-31 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 SUPERFAMILY SSF47384 208 273 2.55E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 PANTHER PTHR24423 209 429 9.4E-37 T 21-04-2016 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 Gene3D G3DSA:1.10.287.130 209 269 5.8E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 Pfam PF00512 His Kinase A (phospho-acceptor) domain 212 273 3.0E-6 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 SMART SM00387 322 430 6.0E-17 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 SUPERFAMILY SSF55874 266 429 4.98E-31 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 328 429 5.5E-17 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 SMART SM00388 211 277 0.0046 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 PRINTS PR00344 Bacterial sensor protein C-terminal signature 415 428 2.3E-7 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 PRINTS PR00344 Bacterial sensor protein C-terminal signature 391 409 2.3E-7 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS23665 ec7643709ecb7610658823d075f2d51d 430 PRINTS PR00344 Bacterial sensor protein C-terminal signature 359 373 2.3E-7 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS20735 345307d762ece0f34cee45dc03c8d708 170 PANTHER PTHR33452 1 155 1.7E-24 T 21-04-2016 SPH21_RS20735 345307d762ece0f34cee45dc03c8d708 170 Pfam PF07681 DoxX 18 100 7.4E-17 T 21-04-2016 IPR032808 DoxX family SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 Gene3D G3DSA:1.10.540.10 11 126 2.7E-43 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 129 223 2.8E-23 T 21-04-2016 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 342 361 - T 21-04-2016 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 SUPERFAMILY SSF47203 234 385 2.09E-58 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 Gene3D G3DSA:1.20.140.10 224 387 1.1E-71 T 21-04-2016 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 PANTHER PTHR10909 3 385 4.5E-174 T 21-04-2016 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 12 124 5.9E-38 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 235 383 4.6E-51 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 SUPERFAMILY SSF56645 8 248 1.02E-88 T 21-04-2016 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 PIRSF PIRSF016578 3 389 2.9E-24 T 21-04-2016 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 Gene3D G3DSA:2.40.110.10 127 223 1.3E-37 T 21-04-2016 SPH21_RS11080 8ec34dcc3e59e4865b27fa818361215c 390 PANTHER PTHR10909:SF305 3 385 4.5E-174 T 21-04-2016 SPH21_RS14685 3ce24fcf235cb9340e27d14f4c1ed175 554 Pfam PF14322 Starch-binding associating with outer membrane 24 222 1.5E-14 T 21-04-2016 SPH21_RS14685 3ce24fcf235cb9340e27d14f4c1ed175 554 Pfam PF07980 SusD family 263 553 5.8E-42 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14685 3ce24fcf235cb9340e27d14f4c1ed175 554 SUPERFAMILY SSF48452 19 553 2.4E-110 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14685 3ce24fcf235cb9340e27d14f4c1ed175 554 Gene3D G3DSA:1.25.40.10 202 310 4.0E-36 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14685 3ce24fcf235cb9340e27d14f4c1ed175 554 Gene3D G3DSA:1.25.40.10 381 489 4.0E-36 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 PANTHER PTHR30173 6 192 7.2E-32 T 21-04-2016 SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 21 174 3.8E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 Pfam PF08281 Sigma-70, region 4 120 171 5.2E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 SUPERFAMILY SSF88946 12 84 1.8E-13 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 Pfam PF04542 Sigma-70 region 2 22 85 1.6E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 SUPERFAMILY SSF88659 121 176 1.27E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 Gene3D G3DSA:1.10.10.10 112 176 2.4E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20955 0cdaf4a64e30b8ff4c08bfb99a947415 192 Gene3D G3DSA:1.10.1740.10 8 86 6.5E-15 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 SUPERFAMILY SSF56935 383 707 6.59E-25 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 SUPERFAMILY SSF56935 759 919 6.59E-25 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 SUPERFAMILY SSF56935 116 252 6.59E-25 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 Pfam PF14905 Outer membrane protein beta-barrel family 458 917 9.8E-49 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 Gene3D G3DSA:2.60.40.1120 25 121 1.9E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 PANTHER PTHR30069 417 672 4.6E-23 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 PANTHER PTHR30069 1 370 4.6E-23 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 PANTHER PTHR30069:SF12 417 672 4.6E-23 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 PANTHER PTHR30069:SF12 1 370 4.6E-23 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 SUPERFAMILY SSF49478 25 94 2.79E-7 T 21-04-2016 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 Gene3D G3DSA:2.40.170.20 369 803 3.8E-7 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 Gene3D G3DSA:2.40.170.20 840 919 3.8E-7 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 Gene3D G3DSA:2.40.170.20 224 251 3.8E-7 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 Gene3D G3DSA:2.40.170.20 286 322 3.8E-7 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS20005 2a85117639bb43afae24fb4db215bc50 926 Pfam PF13620 Carboxypeptidase regulatory-like domain 25 94 8.1E-8 T 21-04-2016 SPH21_RS25220 97994f3fd5b8d4276559ea2b3b0797c1 437 PANTHER PTHR30354 1 437 2.2E-151 T 21-04-2016 SPH21_RS25220 97994f3fd5b8d4276559ea2b3b0797c1 437 TIGRFAM TIGR00791 gntP: transporter, gluconate:H+ symporter (GntP) family 1 437 2.4E-139 T 21-04-2016 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SPH21_RS25220 97994f3fd5b8d4276559ea2b3b0797c1 437 Pfam PF02447 GntP family permease 1 436 5.1E-138 T 21-04-2016 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SPH21_RS25220 97994f3fd5b8d4276559ea2b3b0797c1 437 PIRSF PIRSF002746 1 437 3.7E-134 T 21-04-2016 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SPH21_RS25220 97994f3fd5b8d4276559ea2b3b0797c1 437 PANTHER PTHR30354:SF1 1 437 2.2E-151 T 21-04-2016 SPH21_RS25510 bf49ccc31a5f88c9afd9b036dfe76de6 77 Hamap MF_00373 50S ribosomal protein L28 [rpmB]. 1 71 18.965 T 21-04-2016 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS25510 bf49ccc31a5f88c9afd9b036dfe76de6 77 SUPERFAMILY SSF143800 1 76 6.47E-27 T 21-04-2016 SPH21_RS25510 bf49ccc31a5f88c9afd9b036dfe76de6 77 TIGRFAM TIGR00009 L28: ribosomal protein bL28 1 58 1.1E-25 T 21-04-2016 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS25510 bf49ccc31a5f88c9afd9b036dfe76de6 77 Gene3D G3DSA:2.30.170.40 2 75 9.3E-32 T 21-04-2016 SPH21_RS25510 bf49ccc31a5f88c9afd9b036dfe76de6 77 PANTHER PTHR13528 1 68 8.2E-28 T 21-04-2016 IPR026569 Ribosomal protein L28/L24 GO:0003735 SPH21_RS25510 bf49ccc31a5f88c9afd9b036dfe76de6 77 Pfam PF00830 Ribosomal L28 family 3 61 3.7E-25 T 21-04-2016 IPR026569 Ribosomal protein L28/L24 GO:0003735 SPH21_RS09815 bfaabde790c4dc0a45c28cf85d1ea9ff 398 Pfam PF16401 Domain of unknown function (DUF5009) 11 166 2.9E-13 T 21-04-2016 IPR032176 Domain of unknown function DUF5009 SPH21_RS09815 bfaabde790c4dc0a45c28cf85d1ea9ff 398 PANTHER PTHR31061 7 110 2.9E-13 T 21-04-2016 SPH21_RS09815 bfaabde790c4dc0a45c28cf85d1ea9ff 398 PANTHER PTHR31061:SF2 7 110 2.9E-13 T 21-04-2016 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 SUPERFAMILY SSF49303 237 358 3.17E-22 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Gene3D G3DSA:2.70.98.10 792 1070 3.5E-77 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 SUPERFAMILY SSF49785 29 235 9.07E-62 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 SUPERFAMILY SSF74650 798 1069 1.21E-73 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 69 235 3.2E-45 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 SUPERFAMILY SSF51445 365 517 4.99E-86 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 SUPERFAMILY SSF51445 548 669 4.99E-86 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 ProSitePatterns PS00719 Glycosyl hydrolases family 2 signature 1. 412 437 - T 21-04-2016 IPR023230 Glycoside hydrolase, family 2, conserved site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PANTHER PTHR10066:SF72 544 620 0.0 T 21-04-2016 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PANTHER PTHR10066:SF72 30 514 0.0 T 21-04-2016 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PANTHER PTHR10066:SF72 638 1075 0.0 T 21-04-2016 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Gene3D G3DSA:3.20.20.80 360 668 2.8E-102 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PRINTS PR00132 Glycosyl hydrolase family 2 signature 575 590 1.5E-31 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PRINTS PR00132 Glycosyl hydrolase family 2 signature 371 385 1.5E-31 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PRINTS PR00132 Glycosyl hydrolase family 2 signature 163 178 1.5E-31 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PRINTS PR00132 Glycosyl hydrolase family 2 signature 472 487 1.5E-31 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PRINTS PR00132 Glycosyl hydrolase family 2 signature 402 420 1.5E-31 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 ProSitePatterns PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 472 486 - T 21-04-2016 IPR023232 Glycoside hydrolase, family 2, active site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PANTHER PTHR10066 544 620 0.0 T 21-04-2016 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PANTHER PTHR10066 30 514 0.0 T 21-04-2016 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 PANTHER PTHR10066 638 1075 0.0 T 21-04-2016 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 SUPERFAMILY SSF49303 665 772 5.11E-20 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 SMART SM01038 797 1068 5.1E-97 T 21-04-2016 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Pfam PF02929 Beta galactosidase small chain 801 1067 3.1E-67 T 21-04-2016 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Gene3D G3DSA:2.60.40.320 669 772 2.8E-19 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Gene3D G3DSA:2.60.40.320 225 358 1.6E-32 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Pfam PF16353 Domain of unknown function(DUF4981) 683 771 1.0E-17 T 21-04-2016 IPR032312 Beta-galactosidase, domain 4 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Gene3D G3DSA:2.60.120.260 23 224 2.4E-76 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Pfam PF00703 Glycosyl hydrolases family 2 237 358 1.3E-15 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11535 d64f816915c92d2d417a64c3e6fdc9a0 1086 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 366 672 4.4E-93 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS25030 ed84a38af4b387778af1e60d55519df9 507 Pfam PF04616 Glycosyl hydrolases family 43 31 306 5.6E-69 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS25030 ed84a38af4b387778af1e60d55519df9 507 SUPERFAMILY SSF75005 30 310 4.85E-75 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS25030 ed84a38af4b387778af1e60d55519df9 507 Gene3D G3DSA:2.60.120.200 322 463 1.3E-4 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS25030 ed84a38af4b387778af1e60d55519df9 507 PANTHER PTHR22925 31 308 5.0E-80 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS25030 ed84a38af4b387778af1e60d55519df9 507 PANTHER PTHR22925:SF42 31 308 5.0E-80 T 21-04-2016 SPH21_RS25030 ed84a38af4b387778af1e60d55519df9 507 Gene3D G3DSA:2.115.10.20 30 312 2.5E-79 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02270 63e73bfd09285e028ae7ab220dec6a43 391 PANTHER PTHR30273 1 111 2.5E-52 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS02270 63e73bfd09285e028ae7ab220dec6a43 391 PANTHER PTHR30273 185 391 2.5E-52 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS02270 63e73bfd09285e028ae7ab220dec6a43 391 Pfam PF16344 Domain of unknown function (DUF4974) 291 388 8.8E-19 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS02270 63e73bfd09285e028ae7ab220dec6a43 391 Pfam PF04773 FecR protein 184 279 4.4E-15 T 21-04-2016 IPR006860 FecR protein SPH21_RS02270 63e73bfd09285e028ae7ab220dec6a43 391 PANTHER PTHR30273:SF2 1 111 2.5E-52 T 21-04-2016 SPH21_RS02270 63e73bfd09285e028ae7ab220dec6a43 391 PANTHER PTHR30273:SF2 185 391 2.5E-52 T 21-04-2016 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 SUPERFAMILY SSF56003 31 253 2.89E-37 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 PIRSF PIRSF036389 11 765 9.7E-249 T 21-04-2016 IPR012368 Oxidoreductase molybdopterin-binding subunit, IorB-related SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 334 614 1.3E-33 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 629 712 2.2E-8 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 33 202 1.1E-13 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 PANTHER PTHR11908 70 576 8.6E-194 T 21-04-2016 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 PANTHER PTHR11908 593 762 8.6E-194 T 21-04-2016 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 Gene3D G3DSA:3.90.1170.50 192 306 3.0E-19 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 PANTHER PTHR11908:SF2 70 576 8.6E-194 T 21-04-2016 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 PANTHER PTHR11908:SF2 593 762 8.6E-194 T 21-04-2016 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 SUPERFAMILY SSF56003 332 758 1.16E-112 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 Gene3D G3DSA:3.30.365.10 336 451 3.5E-33 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 Gene3D G3DSA:3.30.365.10 537 761 1.1E-39 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 SMART SM01008 219 309 2.2E-22 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS21205 c65a028662fe66eb95bfc2fb95992b42 766 Gene3D G3DSA:3.30.365.10 41 183 3.5E-34 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 PIRSF PIRSF026306 2 1185 0.0 T 21-04-2016 IPR016834 Uncharacterised conserved protein UCP026306 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 SUPERFAMILY SSF52540 264 342 5.67E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 SUPERFAMILY SSF52540 798 992 5.67E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 SUPERFAMILY SSF52540 668 741 5.67E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 Gene3D G3DSA:3.40.50.300 819 1004 2.4E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 Pfam PF13091 PLD-like domain 1043 1178 1.0E-8 T 21-04-2016 IPR025202 Phospholipase D-like domain SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 Gene3D G3DSA:3.30.870.10 1039 1178 5.5E-13 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 Pfam PF13245 Part of AAA domain 280 348 1.2E-6 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 SUPERFAMILY SSF56024 1039 1177 7.85E-15 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 PANTHER PTHR10887 567 768 1.2E-44 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 PANTHER PTHR10887 261 349 1.2E-44 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 PANTHER PTHR10887 798 992 1.2E-44 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 Gene3D G3DSA:3.40.50.300 704 818 1.1E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 Gene3D G3DSA:3.40.50.300 250 376 1.1E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 PANTHER PTHR10887:SF340 567 768 1.2E-44 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 PANTHER PTHR10887:SF340 261 349 1.2E-44 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 PANTHER PTHR10887:SF340 798 992 1.2E-44 T 21-04-2016 SPH21_RS01280 4c5584f422a226909d843c9ddcf00aa3 1185 Pfam PF13087 AAA domain 801 989 6.9E-27 T 21-04-2016 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 Gene3D G3DSA:3.40.50.2300 1 121 4.3E-33 T 21-04-2016 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 PANTHER PTHR26402:SF578 1 225 7.9E-70 T 21-04-2016 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 222 3.8E-18 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 Pfam PF00072 Response regulator receiver domain 3 112 2.0E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 PANTHER PTHR26402 1 225 7.9E-70 T 21-04-2016 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 SMART SM00862 145 222 1.8E-19 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 SMART SM00448 1 112 2.6E-35 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 SUPERFAMILY SSF52172 1 183 8.64E-35 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20125 41138fa592e8f494757cb7b937e7bd95 227 Gene3D G3DSA:1.10.10.10 124 224 6.0E-26 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 SUPERFAMILY SSF46565 1 110 8.24E-32 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 SMART SM00271 4 62 1.5E-30 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 Pfam PF00226 DnaJ domain 5 67 2.8E-27 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 Gene3D G3DSA:2.60.260.20 211 289 5.9E-20 T 21-04-2016 SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 PANTHER PTHR24078 5 72 3.4E-88 T 21-04-2016 SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 PANTHER PTHR24078 103 306 3.4E-88 T 21-04-2016 SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 SUPERFAMILY SSF49493 137 213 4.32E-15 T 21-04-2016 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 Pfam PF01556 DnaJ C terminal domain 144 288 3.3E-38 T 21-04-2016 IPR002939 Chaperone DnaJ, C-terminal SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 Gene3D G3DSA:2.60.260.20 130 207 1.0E-17 T 21-04-2016 SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 Gene3D G3DSA:1.10.287.110 107 129 4.4E-32 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 Gene3D G3DSA:1.10.287.110 2 72 4.4E-32 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 SUPERFAMILY SSF49493 212 299 4.06E-21 T 21-04-2016 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 ProSitePatterns PS00636 Nt-dnaJ domain signature. 47 66 - T 21-04-2016 IPR018253 DnaJ domain, conserved site SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 PRINTS PR00625 DnaJ domain signature 25 40 1.5E-26 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 PRINTS PR00625 DnaJ domain signature 62 81 1.5E-26 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 PRINTS PR00625 DnaJ domain signature 42 62 1.5E-26 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS03855 b45ffe8039972942570256b50526f5bd 308 PRINTS PR00625 DnaJ domain signature 7 25 1.5E-26 T 21-04-2016 IPR001623 DnaJ domain SPH21_RS13075 c35a0dcdeb5df20e346b792ae422c3f6 300 SUPERFAMILY SSF53474 55 266 7.41E-17 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13075 c35a0dcdeb5df20e346b792ae422c3f6 300 Gene3D G3DSA:3.40.50.1820 55 270 1.1E-16 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS08250 c90c7142971a82e39891bef0e61203f7 250 SMART SM00382 26 215 1.3E-12 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS08250 c90c7142971a82e39891bef0e61203f7 250 Pfam PF00005 ABC transporter 17 165 2.1E-32 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS08250 c90c7142971a82e39891bef0e61203f7 250 Gene3D G3DSA:3.40.50.300 1 230 4.8E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08250 c90c7142971a82e39891bef0e61203f7 250 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS08250 c90c7142971a82e39891bef0e61203f7 250 SUPERFAMILY SSF52540 1 230 6.97E-67 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08250 c90c7142971a82e39891bef0e61203f7 250 PANTHER PTHR24220 3 240 1.1E-105 T 21-04-2016 SPH21_RS08250 c90c7142971a82e39891bef0e61203f7 250 PANTHER PTHR24220:SF567 3 240 1.1E-105 T 21-04-2016 SPH21_RS12175 5e4adaab34431ec5016aa0f441e0f557 425 SUPERFAMILY SSF53474 101 288 4.92E-28 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12175 5e4adaab34431ec5016aa0f441e0f557 425 SUPERFAMILY SSF53474 316 391 4.92E-28 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12175 5e4adaab34431ec5016aa0f441e0f557 425 Gene3D G3DSA:3.40.50.1820 144 391 4.6E-38 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12175 5e4adaab34431ec5016aa0f441e0f557 425 Pfam PF12146 Serine aminopeptidase, S33 187 281 7.8E-10 T 21-04-2016 IPR022742 Serine aminopeptidase, S33 SPH21_RS12175 5e4adaab34431ec5016aa0f441e0f557 425 Pfam PF13026 Protein of unknown function (DUF3887) 28 116 1.2E-16 T 21-04-2016 IPR024981 Domain of unknown function DUF3887 KEGG: 00983+3.1.1.1|MetaCyc: PWY-6303|MetaCyc: PWY-6857 SPH21_RS21620 636b2e6567e05d6e64288e06ce65ba70 161 Gene3D G3DSA:3.10.450.50 6 134 5.0E-20 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS21620 636b2e6567e05d6e64288e06ce65ba70 161 SUPERFAMILY SSF54427 1 147 1.86E-26 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS21620 636b2e6567e05d6e64288e06ce65ba70 161 Pfam PF13577 SnoaL-like domain 5 132 6.9E-20 T 21-04-2016 IPR009959 Polyketide cyclase SnoaL-like domain SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 SUPERFAMILY SSF51735 4 207 8.55E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 4 444 1.3E-103 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 Gene3D G3DSA:3.40.50.720 4 217 1.1E-75 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 PIRSF PIRSF000124 4 463 9.6E-131 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 SUPERFAMILY SSF48179 215 314 4.25E-27 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 215 309 2.2E-30 T 21-04-2016 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 PIRSF PIRSF500133 1 463 1.8E-239 T 21-04-2016 IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type GO:0003979 KEGG: 00040+1.1.1.22|KEGG: 00053+1.1.1.22|KEGG: 00500+1.1.1.22|KEGG: 00520+1.1.1.22|MetaCyc: PWY-7346|UniPathway: UPA00038 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 Gene3D G3DSA:1.20.5.100 218 244 6.2E-14 T 21-04-2016 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 333 448 4.5E-34 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 PANTHER PTHR11374 1 462 0.0 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 SUPERFAMILY SSF52413 318 457 6.15E-33 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 SMART SM00984 333 448 4.7E-38 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 Gene3D G3DSA:3.40.50.720 247 462 1.3E-86 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 PANTHER PTHR11374:SF3 1 462 0.0 T 21-04-2016 SPH21_RS09900 c6072905f7c0158092c1b8f64761b521 463 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 5 189 9.3E-60 T 21-04-2016 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS09200 90276f8cf8d6fd6d34e3ef22534409fe 91 Pfam PF12728 Helix-turn-helix domain 36 86 2.3E-10 T 21-04-2016 SPH21_RS09200 90276f8cf8d6fd6d34e3ef22534409fe 91 SUPERFAMILY SSF46955 36 89 2.75E-7 T 21-04-2016 IPR009061 Putative DNA-binding domain SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 PANTHER PTHR30128 52 177 1.9E-43 T 21-04-2016 SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 SUPERFAMILY SSF103088 62 175 1.2E-34 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 Pfam PF00691 OmpA family 74 169 6.2E-23 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 138 157 1.3E-7 T 21-04-2016 SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 158 177 1.3E-7 T 21-04-2016 SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 120 137 1.3E-7 T 21-04-2016 SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 Gene3D G3DSA:3.30.1330.60 70 175 1.1E-38 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 PRINTS PR01021 OMPA domain signature 75 97 6.6E-11 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 PRINTS PR01021 OMPA domain signature 105 120 6.6E-11 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS19085 b334ab36c4bbb93d0beaa52b722da603 177 PRINTS PR01021 OMPA domain signature 120 136 6.6E-11 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS09990 0116e7efd361a31eb38e9f44f2c0367c 359 SUPERFAMILY SSF53383 2 356 1.46E-92 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS09990 0116e7efd361a31eb38e9f44f2c0367c 359 PIRSF PIRSF000390 1 359 1.8E-97 T 21-04-2016 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SPH21_RS09990 0116e7efd361a31eb38e9f44f2c0367c 359 Gene3D G3DSA:3.90.1150.10 240 356 2.2E-13 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS09990 0116e7efd361a31eb38e9f44f2c0367c 359 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 13 352 2.1E-89 T 21-04-2016 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SPH21_RS09990 0116e7efd361a31eb38e9f44f2c0367c 359 PANTHER PTHR30244 1 359 2.9E-123 T 21-04-2016 SPH21_RS09990 0116e7efd361a31eb38e9f44f2c0367c 359 PANTHER PTHR30244:SF9 1 359 2.9E-123 T 21-04-2016 SPH21_RS09990 0116e7efd361a31eb38e9f44f2c0367c 359 Gene3D G3DSA:3.40.640.10 13 237 9.1E-69 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS08435 e7e6ddb76b38d55211fa2f1830014fc9 304 Pfam PF00294 pfkB family carbohydrate kinase 20 279 1.6E-34 T 21-04-2016 IPR011611 Carbohydrate kinase PfkB SPH21_RS08435 e7e6ddb76b38d55211fa2f1830014fc9 304 Gene3D G3DSA:3.40.1190.20 1 294 1.4E-58 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS08435 e7e6ddb76b38d55211fa2f1830014fc9 304 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 231 244 - T 21-04-2016 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SPH21_RS08435 e7e6ddb76b38d55211fa2f1830014fc9 304 PANTHER PTHR10584 3 304 1.1E-58 T 21-04-2016 SPH21_RS08435 e7e6ddb76b38d55211fa2f1830014fc9 304 PANTHER PTHR10584:SF179 3 304 1.1E-58 T 21-04-2016 SPH21_RS08435 e7e6ddb76b38d55211fa2f1830014fc9 304 SUPERFAMILY SSF53613 1 283 8.57E-58 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS25595 264f1b55fd58f545c49dda85cc777f18 198 Pfam PF03938 Outer membrane protein (OmpH-like) 10 174 6.6E-36 T 21-04-2016 IPR005632 Chaperone protein Skp GO:0051082 SPH21_RS25595 264f1b55fd58f545c49dda85cc777f18 198 SMART SM00935 12 175 8.5E-31 T 21-04-2016 IPR005632 Chaperone protein Skp GO:0051082 SPH21_RS25595 264f1b55fd58f545c49dda85cc777f18 198 Gene3D G3DSA:3.30.910.20 14 61 4.7E-23 T 21-04-2016 SPH21_RS25595 264f1b55fd58f545c49dda85cc777f18 198 Gene3D G3DSA:3.30.910.20 94 174 4.7E-23 T 21-04-2016 SPH21_RS25595 264f1b55fd58f545c49dda85cc777f18 198 PANTHER PTHR35089 2 180 2.7E-22 T 21-04-2016 SPH21_RS25595 264f1b55fd58f545c49dda85cc777f18 198 SUPERFAMILY SSF111384 23 174 1.44E-24 T 21-04-2016 IPR024930 Skp domain SPH21_RS25595 264f1b55fd58f545c49dda85cc777f18 198 PANTHER PTHR35089:SF1 2 180 2.7E-22 T 21-04-2016 SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 ProSitePatterns PS01108 Ribosomal protein L24 signature. 11 28 - T 21-04-2016 IPR005825 Ribosomal protein L24/L26, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 Hamap MF_01326_B 50S ribosomal protein L24 [rplX]. 6 101 21.272 T 21-04-2016 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 SMART SM00739 7 34 1.5E-5 T 21-04-2016 IPR005824 KOW SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 Pfam PF00467 KOW motif 10 41 2.0E-7 T 21-04-2016 IPR005824 KOW SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 Gene3D G3DSA:2.30.30.30 3 95 9.7E-26 T 21-04-2016 IPR014722 Ribosomal protein L2 domain 2 SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 PANTHER PTHR12903 5 107 3.2E-41 T 21-04-2016 SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 Pfam PF17136 Ribosomal proteins 50S L24/mitochondrial 39S L24 44 107 7.6E-28 T 21-04-2016 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 SUPERFAMILY SSF50104 5 105 4.14E-35 T 21-04-2016 IPR008991 Translation protein SH3-like domain SPH21_RS08550 ab298e501b1d2d821f93b010dff3aa20 108 TIGRFAM TIGR01079 rplX_bact: ribosomal protein uL24 5 107 1.4E-34 T 21-04-2016 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 Gene3D G3DSA:1.10.10.10 129 187 2.3E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 30 184 2.7E-22 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 Pfam PF08281 Sigma-70, region 4 130 181 1.2E-9 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 SUPERFAMILY SSF88659 128 186 6.76E-10 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 Gene3D G3DSA:1.10.1740.10 8 108 8.9E-16 T 21-04-2016 SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 SUPERFAMILY SSF88946 7 106 1.77E-15 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 Pfam PF04542 Sigma-70 region 2 31 97 3.6E-11 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06760 a6118aec2692f11f16d8004b8333fd77 190 PANTHER PTHR30173 1 188 3.3E-24 T 21-04-2016 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 ProSitePatterns PS01233 Urocanase signature. 446 461 - T 21-04-2016 IPR023636 Urocanase conserved site GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 PANTHER PTHR12216 17 546 1.4E-290 T 21-04-2016 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 TIGRFAM TIGR01228 hutU: urocanate hydratase 16 551 3.0E-257 T 21-04-2016 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 PIRSF PIRSF001423 1 556 2.4E-261 T 21-04-2016 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 Gene3D G3DSA:3.40.50.10730 146 352 8.3E-80 T 21-04-2016 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 Pfam PF01175 Urocanase 17 548 5.0E-247 T 21-04-2016 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 Gene3D G3DSA:3.40.1770.10 364 554 1.7E-144 T 21-04-2016 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 Gene3D G3DSA:3.40.1770.10 17 145 1.7E-144 T 21-04-2016 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 Hamap MF_00577 Urocanate hydratase [hutU]. 2 556 46.942 T 21-04-2016 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 SUPERFAMILY SSF111326 11 553 2.49E-238 T 21-04-2016 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16445 60397a02db94b79cc803aeaa043e4adc 557 PANTHER PTHR12216:SF3 17 546 1.4E-290 T 21-04-2016 SPH21_RS24050 b7ace38ed872dbcc47b3b765b8add4f8 113 SUPERFAMILY SSF54909 17 111 4.83E-11 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS24050 b7ace38ed872dbcc47b3b765b8add4f8 113 Gene3D G3DSA:3.30.70.1060 1 111 1.2E-15 T 21-04-2016 SPH21_RS24050 b7ace38ed872dbcc47b3b765b8add4f8 113 Pfam PF03795 YCII-related domain 22 109 2.0E-7 T 21-04-2016 IPR005545 YCII-related SPH21_RS05875 aafb3c2891f4c8efd94fb04b5621bd20 427 Pfam PF01103 Surface antigen 184 398 1.8E-7 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS25945 5009afeba1ed49675ded9f7e0a590fa8 106 Pfam PF01883 Domain of unknown function DUF59 12 82 1.6E-16 T 21-04-2016 IPR002744 Domain of unknown function DUF59 SPH21_RS25945 5009afeba1ed49675ded9f7e0a590fa8 106 PANTHER PTHR13696 9 103 1.2E-20 T 21-04-2016 SPH21_RS25945 5009afeba1ed49675ded9f7e0a590fa8 106 SUPERFAMILY SSF117916 10 104 3.24E-29 T 21-04-2016 SPH21_RS25945 5009afeba1ed49675ded9f7e0a590fa8 106 PANTHER PTHR13696:SF62 9 103 1.2E-20 T 21-04-2016 SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 SUPERFAMILY SSF51735 3 229 1.13E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 172 9.6E-12 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 9.6E-12 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 9.6E-12 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 Gene3D G3DSA:3.40.50.720 3 229 4.5E-51 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 Pfam PF00106 short chain dehydrogenase 3 197 6.1E-41 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PANTHER PTHR24322 153 184 1.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PANTHER PTHR24322 5 134 1.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 191 3.2E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 2 19 3.2E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 3.2E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 3.2E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25410 7fbdb54f5d43ecc194340311c9251ce8 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 153 172 3.2E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 SUPERFAMILY SSF51971 143 405 2.47E-63 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PANTHER PTHR11938 36 317 5.2E-146 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PANTHER PTHR11938 333 473 5.2E-146 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 SUPERFAMILY SSF46548 2 154 2.62E-37 T 21-04-2016 IPR009051 Alpha-helical ferredoxin GO:0051536 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 Gene3D G3DSA:3.50.50.60 146 240 1.9E-28 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 TIGRFAM TIGR01317 GOGAT_sm_gam: glutamate synthase, NADH/NADPH, small subunit 3 478 1.7E-201 T 21-04-2016 IPR006005 Glutamate synthase, NADH/NADPH, small subunit 1 GO:0006537|GO:0016639|GO:0055114 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 145 317 3.2E-16 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PRINTS PR00419 Adrenodoxin reductase family signature 210 220 7.8E-23 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PRINTS PR00419 Adrenodoxin reductase family signature 284 298 7.8E-23 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PRINTS PR00419 Adrenodoxin reductase family signature 168 181 7.8E-23 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PRINTS PR00419 Adrenodoxin reductase family signature 145 167 7.8E-23 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 SUPERFAMILY SSF51971 389 482 4.12E-7 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PANTHER PTHR11938:SF75 36 317 5.2E-146 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 PANTHER PTHR11938:SF75 333 473 5.2E-146 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 Gene3D G3DSA:3.50.50.60 241 395 7.9E-38 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 Gene3D G3DSA:1.10.1060.10 3 145 1.6E-41 T 21-04-2016 SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 Pfam PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster 24 130 3.2E-28 T 21-04-2016 IPR028261 Dihydroprymidine dehydrogenase domain II SPH21_RS15855 f047d0ea635716137c8a3e8a6fe32de8 488 Gene3D G3DSA:3.50.50.60 396 475 5.0E-18 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15025 e5f4c19125778e5c978a95e2fdd39b9e 108 SUPERFAMILY SSF89360 1 96 1.1E-26 T 21-04-2016 IPR000361 FeS cluster biogenesis SPH21_RS15025 e5f4c19125778e5c978a95e2fdd39b9e 108 Gene3D G3DSA:2.60.300.12 1 97 1.3E-30 T 21-04-2016 IPR000361 FeS cluster biogenesis SPH21_RS15025 e5f4c19125778e5c978a95e2fdd39b9e 108 Pfam PF01521 Iron-sulphur cluster biosynthesis 2 103 9.7E-19 T 21-04-2016 IPR000361 FeS cluster biogenesis SPH21_RS15025 e5f4c19125778e5c978a95e2fdd39b9e 108 PANTHER PTHR10072 1 108 3.0E-42 T 21-04-2016 SPH21_RS15025 e5f4c19125778e5c978a95e2fdd39b9e 108 TIGRFAM TIGR00049 TIGR00049: iron-sulfur cluster assembly accessory protein 2 108 4.9E-36 T 21-04-2016 IPR016092 FeS cluster insertion protein GO:0005198|GO:0016226|GO:0051536 SPH21_RS15025 e5f4c19125778e5c978a95e2fdd39b9e 108 ProSitePatterns PS01152 Hypothetical hesB/yadR/yfhF family signature. 89 106 - T 21-04-2016 IPR017870 FeS cluster insertion, C-terminal, conserved site SPH21_RS18250 7bb0fa52d8aef448373b5e06cb7c868d 403 PANTHER PTHR30097 48 342 4.7E-31 T 21-04-2016 SPH21_RS18250 7bb0fa52d8aef448373b5e06cb7c868d 403 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 68 344 5.7E-30 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS18250 7bb0fa52d8aef448373b5e06cb7c868d 403 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 72 294 1.5E-26 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS18250 7bb0fa52d8aef448373b5e06cb7c868d 403 Gene3D G3DSA:2.40.50.100 197 233 1.9E-9 T 21-04-2016 SPH21_RS18250 7bb0fa52d8aef448373b5e06cb7c868d 403 Gene3D G3DSA:2.40.50.100 85 120 1.9E-9 T 21-04-2016 SPH21_RS18250 7bb0fa52d8aef448373b5e06cb7c868d 403 PANTHER PTHR30097:SF4 48 342 4.7E-31 T 21-04-2016 SPH21_RS18250 7bb0fa52d8aef448373b5e06cb7c868d 403 SUPERFAMILY SSF111369 85 314 7.72E-11 T 21-04-2016 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 PANTHER PTHR30146 5 338 2.7E-87 T 21-04-2016 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 SUPERFAMILY SSF53822 64 337 7.43E-53 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 Gene3D G3DSA:1.10.260.40 7 60 2.4E-20 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 55 9.3E-9 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 Gene3D G3DSA:3.40.50.2300 179 310 7.7E-31 T 21-04-2016 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 SMART SM00354 5 78 3.9E-15 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 Gene3D G3DSA:3.40.50.2300 61 178 2.3E-45 T 21-04-2016 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 SUPERFAMILY SSF47413 7 63 4.22E-13 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS25195 d487aaa7cb3d5bd9dd3d6fa7e99bcf92 340 Pfam PF13377 Periplasmic binding protein-like domain 176 337 1.6E-25 T 21-04-2016 SPH21_RS15615 89fa2d5fe461fb632e30969eeb7d6723 134 Pfam PF00472 RF-1 domain 11 127 8.8E-18 T 21-04-2016 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SPH21_RS15615 89fa2d5fe461fb632e30969eeb7d6723 134 SUPERFAMILY SSF110916 14 97 1.27E-11 T 21-04-2016 SPH21_RS15615 89fa2d5fe461fb632e30969eeb7d6723 134 PANTHER PTHR11075 11 130 1.3E-19 T 21-04-2016 SPH21_RS15615 89fa2d5fe461fb632e30969eeb7d6723 134 Gene3D G3DSA:3.30.160.200 11 103 2.0E-24 T 21-04-2016 SPH21_RS15615 89fa2d5fe461fb632e30969eeb7d6723 134 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 17 33 - T 21-04-2016 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 3696 3796 7.4E-20 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 TIGRFAM TIGR01451 B_ant_repeat: conserved repeat domain 1754 1798 2.1E-14 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 TIGRFAM TIGR01451 B_ant_repeat: conserved repeat domain 1475 1514 1.1E-10 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 TIGRFAM TIGR01451 B_ant_repeat: conserved repeat domain 1618 1662 1.4E-11 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 TIGRFAM TIGR01451 B_ant_repeat: conserved repeat domain 1897 1938 3.3E-9 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF01345 Domain of unknown function DUF11 1474 1514 1.8E-8 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF01345 Domain of unknown function DUF11 1754 1798 1.4E-12 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF01345 Domain of unknown function DUF11 1616 1656 6.8E-10 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF01345 Domain of unknown function DUF11 1893 1938 2.0E-6 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 3694 3785 1.96E-18 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 PANTHER PTHR34819 1478 2019 5.5E-35 T 21-04-2016 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.670 2280 2344 4.1E-4 T 21-04-2016 IPR000601 PKD domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 4312 4406 5.7E-23 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 4108 4202 1.4E-22 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 4006 4100 1.1E-21 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 4414 4508 1.5E-21 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 4516 4610 9.0E-21 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 4210 4304 1.6E-22 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 3904 3998 1.4E-22 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.920 3802 3896 1.4E-22 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 3999 4099 3.34E-20 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 PANTHER PTHR34819:SF3 1478 2019 5.5E-35 T 21-04-2016 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 3897 3997 4.71E-21 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 3806 3885 2.7E-11 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 3702 3782 1.1E-10 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 4519 4596 7.5E-9 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 4316 4396 1.0E-11 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 4418 4496 2.1E-10 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 3908 3987 2.7E-11 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 4112 4191 2.7E-11 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 4214 4293 2.5E-11 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF02369 Bacterial Ig-like domain (group 1) 4010 4089 1.8E-10 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF48726 3602 3692 4.16E-5 T 21-04-2016 IPR007110 Immunoglobulin-like domain GO:0005515 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 TIGRFAM TIGR04131 Bac_Flav_CTERM: gliding motility-associated C-terminal domain 5106 5187 1.1E-14 T 21-04-2016 IPR026341 Gliding motility-associated, C-terminal domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 4101 4201 4.91E-21 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 4305 4405 3.34E-21 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Pfam PF13585 C-terminal domain of CHU protein family 5105 5185 3.8E-26 T 21-04-2016 SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 4203 4303 8.44E-21 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 3795 3895 4.51E-21 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49299 2231 2345 1.12E-5 T 21-04-2016 IPR000601 PKD domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 4209 4299 3.1E-15 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 4107 4197 6.9E-16 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 3903 3993 6.9E-16 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 4005 4095 3.2E-14 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 3801 3891 6.9E-16 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 3698 3788 3.9E-18 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 4311 4401 2.5E-16 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 4413 4502 4.8E-14 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SMART SM00634 4515 4605 2.1E-13 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 4509 4609 1.94E-18 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 SUPERFAMILY SSF49373 4407 4506 7.65E-20 T 21-04-2016 IPR008964 Invasin/intimin cell-adhesion fragments SPH21_RS10305 e79ae247d1878c95f26c568d87c53b5b 5188 Gene3D G3DSA:2.60.40.10 3596 3691 1.1E-4 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 Pfam PF00265 Thymidine kinase 16 188 1.7E-56 T 21-04-2016 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199 SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 PIRSF PIRSF035805 14 193 4.4E-64 T 21-04-2016 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199 SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 SUPERFAMILY SSF57716 149 191 1.85E-11 T 21-04-2016 SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 SUPERFAMILY SSF52540 16 148 7.79E-42 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 Gene3D G3DSA:3.30.60.20 149 191 9.3E-17 T 21-04-2016 SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 Hamap MF_00124 Thymidine kinase [tdk]. 15 191 32.713 T 21-04-2016 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199 SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 ProSitePatterns PS00603 Thymidine kinase cellular-type signature. 175 188 - T 21-04-2016 IPR020633 Thymidine kinase, conserved site GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199 SPH21_RS11715 5836fc8b8cc20393f9f58ed29bc24237 193 PANTHER PTHR11441 1 191 4.1E-80 T 21-04-2016 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199 SPH21_RS05595 da6e837169fa2bad72de67284d8e61aa 391 Gene3D G3DSA:2.30.40.10 12 67 2.7E-5 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS05595 da6e837169fa2bad72de67284d8e61aa 391 SUPERFAMILY SSF51556 56 357 8.35E-42 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS05595 da6e837169fa2bad72de67284d8e61aa 391 Gene3D G3DSA:3.20.20.140 68 356 1.6E-34 T 21-04-2016 SPH21_RS05595 da6e837169fa2bad72de67284d8e61aa 391 PANTHER PTHR11271 231 367 3.1E-26 T 21-04-2016 SPH21_RS05595 da6e837169fa2bad72de67284d8e61aa 391 PANTHER PTHR11271 16 213 3.1E-26 T 21-04-2016 SPH21_RS05595 da6e837169fa2bad72de67284d8e61aa 391 Pfam PF01979 Amidohydrolase family 53 374 1.1E-30 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 Pfam PF08281 Sigma-70, region 4 123 170 6.0E-11 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 SUPERFAMILY SSF88659 119 180 9.59E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 SUPERFAMILY SSF88946 2 94 9.42E-22 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 PANTHER PTHR30173 1 192 6.3E-38 T 21-04-2016 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 Gene3D G3DSA:1.10.1740.10 3 117 2.3E-23 T 21-04-2016 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 Gene3D G3DSA:1.10.10.10 118 180 4.0E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 Pfam PF04542 Sigma-70 region 2 25 90 1.0E-10 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 21 178 4.0E-28 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04145 7ca7f8fa0576a53bc9837c78260470c7 195 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 21 178 1.7E-37 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 Pfam PF02777 Iron/manganese superoxide dismutases, C-terminal domain 131 233 2.5E-41 T 21-04-2016 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 ProSitePatterns PS00088 Manganese and iron superoxide dismutases signature. 200 207 - T 21-04-2016 IPR019833 Manganese/iron superoxide dismutase, binding site GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 PIRSF PIRSF000349 18 235 5.0E-78 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 PANTHER PTHR11404 14 234 2.3E-83 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 PRINTS PR01703 Manganese superoxide dismutase signature 160 168 7.3E-19 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 PRINTS PR01703 Manganese superoxide dismutase signature 67 80 7.3E-19 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 PRINTS PR01703 Manganese superoxide dismutase signature 108 121 7.3E-19 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 PRINTS PR01703 Manganese superoxide dismutase signature 46 57 7.3E-19 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 PRINTS PR01703 Manganese superoxide dismutase signature 198 210 7.3E-19 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 Gene3D G3DSA:1.10.287.990 60 125 4.0E-20 T 21-04-2016 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 Pfam PF00081 Iron/manganese superoxide dismutases, alpha-hairpin domain 43 124 1.2E-22 T 21-04-2016 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 SUPERFAMILY SSF54719 129 234 3.01E-43 T 21-04-2016 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS21275 6c5d1b86276bbc736e7622b3a8a5238c 235 SUPERFAMILY SSF46609 39 126 5.63E-25 T 21-04-2016 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS02895 ca4c9efae4845fdff432e27dd68484d3 510 Pfam PF14322 Starch-binding associating with outer membrane 68 221 1.0E-25 T 21-04-2016 SPH21_RS02895 ca4c9efae4845fdff432e27dd68484d3 510 Pfam PF07980 SusD family 263 510 2.5E-41 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS02895 ca4c9efae4845fdff432e27dd68484d3 510 Gene3D G3DSA:1.25.40.10 201 314 4.8E-38 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02895 ca4c9efae4845fdff432e27dd68484d3 510 Gene3D G3DSA:1.25.40.10 355 449 4.8E-38 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02895 ca4c9efae4845fdff432e27dd68484d3 510 SUPERFAMILY SSF48452 18 510 1.14E-113 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03540 c40090303891c7d28b58c72f2d314f91 255 PANTHER PTHR23200:SF41 38 235 1.6E-22 T 21-04-2016 SPH21_RS03540 c40090303891c7d28b58c72f2d314f91 255 PANTHER PTHR23200 38 235 1.6E-22 T 21-04-2016 SPH21_RS03540 c40090303891c7d28b58c72f2d314f91 255 SMART SM00849 39 235 5.0E-5 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS03540 c40090303891c7d28b58c72f2d314f91 255 Pfam PF00753 Metallo-beta-lactamase superfamily 43 228 1.2E-14 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS03540 c40090303891c7d28b58c72f2d314f91 255 SUPERFAMILY SSF56281 39 246 2.1E-24 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS03540 c40090303891c7d28b58c72f2d314f91 255 Gene3D G3DSA:3.60.15.10 32 250 3.7E-30 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS25250 c19a1428f5fb0b1e430847f8ac4e7caf 118 Pfam PF00072 Response regulator receiver domain 5 114 8.2E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS25250 c19a1428f5fb0b1e430847f8ac4e7caf 118 Gene3D G3DSA:3.40.50.2300 4 116 2.7E-26 T 21-04-2016 SPH21_RS25250 c19a1428f5fb0b1e430847f8ac4e7caf 118 PANTHER PTHR26402 3 114 5.1E-27 T 21-04-2016 SPH21_RS25250 c19a1428f5fb0b1e430847f8ac4e7caf 118 SUPERFAMILY SSF52172 4 116 8.82E-27 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS25250 c19a1428f5fb0b1e430847f8ac4e7caf 118 SMART SM00448 3 114 4.5E-23 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 Gene3D G3DSA:3.40.50.800 294 413 7.6E-43 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 Pfam PF09180 Prolyl-tRNA synthetase, C-terminal 423 490 7.6E-24 T 21-04-2016 IPR016061 Proline-tRNA ligase, class II, C-terminal GO:0000166|GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 SUPERFAMILY SSF52954 289 415 3.32E-34 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 TIGRFAM TIGR00408 proS_fam_I: proline--tRNA ligase 6 490 2.4E-168 T 21-04-2016 IPR004499 Proline-tRNA ligase, class IIa, archaeal-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 PANTHER PTHR11451 1 464 2.5E-239 T 21-04-2016 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 SUPERFAMILY SSF55681 10 287 5.24E-75 T 21-04-2016 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 PANTHER PTHR11451:SF6 1 464 2.5E-239 T 21-04-2016 IPR004499 Proline-tRNA ligase, class IIa, archaeal-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 Pfam PF03129 Anticodon binding domain 300 396 2.7E-20 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 Gene3D G3DSA:3.30.110.30 417 489 8.5E-33 T 21-04-2016 IPR016061 Proline-tRNA ligase, class II, C-terminal GO:0000166|GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 SUPERFAMILY SSF64586 418 490 2.35E-23 T 21-04-2016 IPR017449 Prolyl-tRNA synthetase, class II GO:0000166|GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 112 281 5.9E-16 T 21-04-2016 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 SMART SM00946 423 490 1.2E-33 T 21-04-2016 IPR016061 Proline-tRNA ligase, class II, C-terminal GO:0000166|GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 Hamap MF_01571 Proline--tRNA ligase [proS]. 5 490 44.753 T 21-04-2016 IPR004499 Proline-tRNA ligase, class IIa, archaeal-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SPH21_RS22935 0e808966fedcd95ca986997e2470c7f7 490 Gene3D G3DSA:3.30.930.10 3 293 1.1E-109 T 21-04-2016 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 Pfam PF00289 Biotin carboxylase, N-terminal domain 1 110 2.5E-45 T 21-04-2016 IPR005481 Biotin carboxylase-like, N-terminal domain SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 TIGRFAM TIGR00514 accC: acetyl-CoA carboxylase, biotin carboxylase subunit 1 443 2.7E-223 T 21-04-2016 IPR004549 Acetyl-CoA carboxylase, biotin carboxylase GO:0016874 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 Gene3D G3DSA:3.30.470.20 203 441 8.8E-103 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 286 293 - T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 153 167 - T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 SUPERFAMILY SSF56059 83 350 1.26E-69 T 21-04-2016 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 Gene3D G3DSA:3.30.1490.20 130 202 3.5E-30 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 115 322 2.1E-78 T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 SMART SM00878 334 440 1.5E-69 T 21-04-2016 IPR005482 Biotin carboxylase, C-terminal SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 SUPERFAMILY SSF51246 331 441 1.62E-45 T 21-04-2016 IPR011054 Rudiment single hybrid motif SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 Pfam PF02785 Biotin carboxylase C-terminal domain 334 440 1.4E-43 T 21-04-2016 IPR005482 Biotin carboxylase, C-terminal SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 Gene3D G3DSA:3.40.50.20 1 129 1.3E-53 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 SUPERFAMILY SSF52440 1 113 6.19E-49 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS00065 cf5c72407356f86af85424272d05d191 446 PANTHER PTHR18866 1 440 1.9E-303 T 21-04-2016 SPH21_RS09520 f82eb376f4c90befcc469f5a0d6abbbe 356 PANTHER PTHR30273 135 355 5.6E-30 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09520 f82eb376f4c90befcc469f5a0d6abbbe 356 PANTHER PTHR30273:SF2 135 355 5.6E-30 T 21-04-2016 SPH21_RS09520 f82eb376f4c90befcc469f5a0d6abbbe 356 Pfam PF04773 FecR protein 140 230 4.3E-14 T 21-04-2016 IPR006860 FecR protein SPH21_RS09520 f82eb376f4c90befcc469f5a0d6abbbe 356 Pfam PF16344 Domain of unknown function (DUF4974) 281 348 1.3E-7 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 Gene3D G3DSA:1.10.10.10 12 70 4.6E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 Gene3D G3DSA:3.40.640.10 132 347 3.0E-54 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 PANTHER PTHR11751 84 463 1.7E-74 T 21-04-2016 SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 SMART SM00345 8 68 8.6E-13 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 Pfam PF00392 Bacterial regulatory proteins, gntR family 13 68 4.4E-12 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 SUPERFAMILY SSF53383 101 461 5.35E-78 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 Gene3D G3DSA:3.90.1150.10 348 460 1.8E-9 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 Pfam PF00155 Aminotransferase class I and II 126 445 3.7E-29 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 SUPERFAMILY SSF46785 12 71 6.17E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23230 46e7c835012d1c2c188b867a0d44786f 464 PANTHER PTHR11751:SF314 84 463 1.7E-74 T 21-04-2016 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 14 438 7.7E-123 T 21-04-2016 IPR005839 Methylthiotransferase GO:0016740|GO:0043412|GO:0051539 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 TIGRFAM TIGR01125 TIGR01125: ribosomal protein S12 methylthiotransferase RimO 14 438 2.0E-145 T 21-04-2016 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 PANTHER PTHR11918 8 440 4.6E-177 T 21-04-2016 IPR023970 Methylthiotransferase/radical SAM-type protein SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 SMART SM00729 146 364 5.8E-47 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 PANTHER PTHR11918:SF57 8 440 4.6E-177 T 21-04-2016 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 Pfam PF04055 Radical SAM superfamily 152 322 6.4E-23 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 Gene3D G3DSA:3.80.30.20 144 377 1.1E-72 T 21-04-2016 IPR023404 Radical SAM, alpha/beta horseshoe SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 SUPERFAMILY SSF102114 110 372 2.62E-57 T 21-04-2016 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 Pfam PF00919 Uncharacterized protein family UPF0004 14 116 3.2E-26 T 21-04-2016 IPR013848 Methylthiotransferase, N-terminal GO:0003824|GO:0009451|GO:0051539 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 Pfam PF01938 TRAM domain 376 440 9.0E-7 T 21-04-2016 IPR002792 TRAM domain SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 Hamap MF_01865 Ribosomal protein S12 methylthiotransferase RimO [rimO]. 13 440 62.293 T 21-04-2016 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 SPH21_RS25530 af317445484f1be18b1fc237d4befeb1 442 Gene3D G3DSA:2.40.50.140 379 440 4.3E-20 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 205 235 9.9E-20 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Pfam PF13715 CarboxypepD_reg-like domain 33 115 2.5E-21 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Gene3D G3DSA:2.60.40.1120 32 118 3.4E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Gene3D G3DSA:2.40.170.20 841 883 1.6E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Gene3D G3DSA:2.40.170.20 923 996 1.6E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Gene3D G3DSA:2.40.170.20 319 789 1.6E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Gene3D G3DSA:2.40.170.20 230 249 1.6E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 32 996 2.4E-266 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Gene3D G3DSA:2.170.130.10 119 229 3.0E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Pfam PF00593 TonB dependent receptor 600 994 6.3E-17 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 SUPERFAMILY SSF49464 30 113 4.32E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 SUPERFAMILY SSF56935 426 764 3.3E-93 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 SUPERFAMILY SSF56935 831 876 3.3E-93 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 SUPERFAMILY SSF56935 111 253 3.3E-93 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 SUPERFAMILY SSF56935 310 398 3.3E-93 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 SUPERFAMILY SSF56935 913 996 3.3E-93 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 PANTHER PTHR11532:SF57 497 994 1.5E-248 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 PANTHER PTHR11532:SF57 6 421 1.5E-248 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 Pfam PF07715 TonB-dependent Receptor Plug Domain 122 229 2.7E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 PANTHER PTHR11532 497 994 1.5E-248 T 21-04-2016 SPH21_RS14350 5f4bb63df0a45d3e20c8d76af25f53bb 996 PANTHER PTHR11532 6 421 1.5E-248 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 PANTHER PTHR32060 56 1069 1.2E-58 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SUPERFAMILY SSF52096 692 770 2.49E-49 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SUPERFAMILY SSF52096 856 1067 2.49E-49 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF00595 PDZ domain (Also known as DHR or GLGF) 769 842 2.5E-8 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Gene3D G3DSA:2.120.10.60 625 684 1.3E-42 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Gene3D G3DSA:2.120.10.60 48 322 5.5E-60 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Gene3D G3DSA:2.120.10.60 340 543 1.3E-42 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SMART SM00228 771 845 2.1E-12 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SUPERFAMILY SSF82171 338 548 2.55E-36 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SUPERFAMILY SSF82171 580 668 2.55E-36 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SUPERFAMILY SSF50156 767 854 4.21E-12 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF07676 WD40-like Beta Propeller Repeat 50 67 0.21 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF07676 WD40-like Beta Propeller Repeat 80 115 5.6E-8 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF07676 WD40-like Beta Propeller Repeat 525 537 0.2 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF07676 WD40-like Beta Propeller Repeat 123 161 0.0042 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF07676 WD40-like Beta Propeller Repeat 374 398 0.0019 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF07676 WD40-like Beta Propeller Repeat 235 268 2.2E-6 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Gene3D G3DSA:2.30.42.10 770 856 3.2E-12 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Gene3D G3DSA:3.30.750.44 691 760 3.8E-20 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region 406 508 1.3E-6 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 PANTHER PTHR32060:SF12 56 1069 1.2E-58 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SUPERFAMILY SSF69304 51 319 3.92E-41 T 21-04-2016 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 PIRSF PIRSF036421 45 1073 1.9E-150 T 21-04-2016 IPR012393 Tricorn protease GO:0008236 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF03572 Peptidase family S41 884 1032 2.7E-18 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Pfam PF14684 Tricorn protease C1 domain 694 761 2.0E-20 T 21-04-2016 IPR028204 Tricorn protease C1 domain SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 SMART SM00245 845 1042 3.3E-7 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS04920 3a987c1bae123f1b79f305061e3e89e4 1074 Gene3D G3DSA:3.90.226.10 863 1069 1.4E-29 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS23930 92786fa25767225397abda771c175bdb 107 Gene3D G3DSA:3.10.450.50 5 104 3.7E-6 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS23930 92786fa25767225397abda771c175bdb 107 SUPERFAMILY SSF54427 5 106 1.38E-8 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS03145 4b25f3972622b4480a791b76221ee21b 614 Pfam PF14322 Starch-binding associating with outer membrane 108 230 1.3E-17 T 21-04-2016 SPH21_RS03145 4b25f3972622b4480a791b76221ee21b 614 SUPERFAMILY SSF48452 561 595 1.61E-86 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03145 4b25f3972622b4480a791b76221ee21b 614 SUPERFAMILY SSF48452 22 529 1.61E-86 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03145 4b25f3972622b4480a791b76221ee21b 614 Pfam PF07980 SusD family 353 595 7.4E-31 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS03145 4b25f3972622b4480a791b76221ee21b 614 Gene3D G3DSA:1.25.40.10 210 316 1.6E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03145 4b25f3972622b4480a791b76221ee21b 614 Gene3D G3DSA:1.25.40.10 416 502 1.6E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07500 6a65821c8a7b7b4e0c70dd3266d2d168 384 Gene3D G3DSA:2.20.110.10 81 221 1.1E-6 T 21-04-2016 SPH21_RS07500 6a65821c8a7b7b4e0c70dd3266d2d168 384 SUPERFAMILY SSF82185 82 157 1.44E-13 T 21-04-2016 SPH21_RS04790 e2e4a663236fb343c9d865b28ecc861b 287 PANTHER PTHR10963 35 285 8.6E-37 T 21-04-2016 SPH21_RS04790 e2e4a663236fb343c9d865b28ecc861b 287 Pfam PF00722 Glycosyl hydrolases family 16 73 282 3.1E-23 T 21-04-2016 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 SPH21_RS04790 e2e4a663236fb343c9d865b28ecc861b 287 SUPERFAMILY SSF49899 32 286 1.09E-59 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS04790 e2e4a663236fb343c9d865b28ecc861b 287 Gene3D G3DSA:2.60.120.200 31 286 2.8E-64 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS01940 4ccc476828f74e3d1cc9aded9da58578 402 PANTHER PTHR30106:SF4 47 401 4.9E-92 T 21-04-2016 SPH21_RS01940 4ccc476828f74e3d1cc9aded9da58578 402 ProDom PD968187 BETA-DEFENSIN ANTIBIOTIC PRECURSOR ANTIMICROBIAL DEFENSIN BETA SIGNAL DEFENSIN BD-32 DEFB-32 154 392 1.0E-9 T 21-04-2016 SPH21_RS01940 4ccc476828f74e3d1cc9aded9da58578 402 PANTHER PTHR30106 47 401 4.9E-92 T 21-04-2016 IPR018383 Uncharacterised protein family UPF0324, prokaryote GO:0016021 SPH21_RS01940 4ccc476828f74e3d1cc9aded9da58578 402 Pfam PF03601 Conserved hypothetical protein 698 70 376 1.4E-53 T 21-04-2016 IPR018383 Uncharacterised protein family UPF0324, prokaryote GO:0016021 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PANTHER PTHR32063:SF9 1 1039 0.0 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82866 836 1031 1.27E-41 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 Pfam PF00873 AcrB/AcrD/AcrF family 1 1031 0.0 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 Gene3D G3DSA:3.30.70.1430 573 676 1.8E-21 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 Gene3D G3DSA:3.30.2090.10 184 272 8.7E-24 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PANTHER PTHR32063 1 1039 0.0 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82714 727 812 1.57E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 Gene3D G3DSA:3.30.2090.10 727 812 1.6E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 Gene3D G3DSA:1.10.3850.10 819 1032 6.3E-53 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 Gene3D G3DSA:1.20.1640.10 294 508 4.1E-57 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82693 143 183 1.92E-20 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82693 274 329 1.92E-20 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82693 38 131 2.88E-26 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 1 1040 0.0 T 21-04-2016 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0005215|GO:0006810|GO:0016021 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82714 185 271 9.42E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82693 571 676 1.18E-21 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82693 813 862 1.15E-24 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 Gene3D G3DSA:3.30.70.1430 38 140 2.3E-32 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82693 678 726 1.15E-24 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 SUPERFAMILY SSF82866 300 498 8.76E-49 T 21-04-2016 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 558 575 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 336 359 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 36 54 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 391 415 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 445 468 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 470 493 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 8 32 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 363 384 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14060 72e4ed1d70e88461fcaa07af4c997b56 1065 PRINTS PR00702 Acriflavin resistance protein family signature 627 641 2.0E-96 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS06605 c7d8e575fafce29376021007b4c44941 408 PANTHER PTHR30489 7 408 1.7E-36 T 21-04-2016 SPH21_RS06605 c7d8e575fafce29376021007b4c44941 408 Pfam PF12704 MacB-like periplasmic core domain 25 246 1.0E-7 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS06605 c7d8e575fafce29376021007b4c44941 408 Pfam PF02687 FtsX-like permease family 277 397 2.7E-12 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PANTHER PTHR30523 88 857 3.9E-160 T 21-04-2016 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 143 156 9.7E-30 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 242 257 9.7E-30 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 691 717 9.7E-30 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 514 534 9.7E-30 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 556 585 9.7E-30 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 184 200 9.7E-30 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 Pfam PF00311 Phosphoenolpyruvate carboxylase 309 853 4.2E-112 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 Pfam PF00311 Phosphoenolpyruvate carboxylase 140 302 1.8E-18 T 21-04-2016 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SPH21_RS15760 8624359924737c098c980382a20feac6 861 PANTHER PTHR30523:SF0 88 857 3.9E-160 T 21-04-2016 SPH21_RS15760 8624359924737c098c980382a20feac6 861 SUPERFAMILY SSF51621 36 856 3.92E-192 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS01105 08a66620fbdad03c600ea75e9fa51adb 400 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 81 362 3.4E-28 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS01105 08a66620fbdad03c600ea75e9fa51adb 400 SUPERFAMILY SSF111369 84 310 1.31E-15 T 21-04-2016 SPH21_RS01105 08a66620fbdad03c600ea75e9fa51adb 400 PANTHER PTHR30097 32 364 4.2E-43 T 21-04-2016 SPH21_RS01105 08a66620fbdad03c600ea75e9fa51adb 400 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 69 287 6.5E-28 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS01105 08a66620fbdad03c600ea75e9fa51adb 400 PANTHER PTHR30097:SF4 32 364 4.2E-43 T 21-04-2016 SPH21_RS01105 08a66620fbdad03c600ea75e9fa51adb 400 Gene3D G3DSA:2.40.50.100 199 232 2.9E-11 T 21-04-2016 SPH21_RS01105 08a66620fbdad03c600ea75e9fa51adb 400 Gene3D G3DSA:2.40.50.100 87 119 2.9E-11 T 21-04-2016 SPH21_RS20155 0d16cd92d71ca48a41c1bff8d78785d2 209 PANTHER PTHR30363:SF9 1 206 2.4E-64 T 21-04-2016 SPH21_RS20155 0d16cd92d71ca48a41c1bff8d78785d2 209 PANTHER PTHR30363 1 206 2.4E-64 T 21-04-2016 SPH21_RS20155 0d16cd92d71ca48a41c1bff8d78785d2 209 Gene3D G3DSA:1.10.10.10 11 105 5.0E-8 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20155 0d16cd92d71ca48a41c1bff8d78785d2 209 SUPERFAMILY SSF46785 12 187 1.41E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14120 178a362bfd8eb616924048e4cf07c5b0 336 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 40 167 2.4E-9 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS14120 178a362bfd8eb616924048e4cf07c5b0 336 SUPERFAMILY SSF51735 40 194 1.63E-19 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14120 178a362bfd8eb616924048e4cf07c5b0 336 PANTHER PTHR22604:SF107 40 336 1.7E-112 T 21-04-2016 SPH21_RS14120 178a362bfd8eb616924048e4cf07c5b0 336 PANTHER PTHR22604 40 336 1.7E-112 T 21-04-2016 SPH21_RS14120 178a362bfd8eb616924048e4cf07c5b0 336 Gene3D G3DSA:3.40.50.720 40 198 2.0E-19 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 SUPERFAMILY SSF56935 514 851 1.19E-86 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 SUPERFAMILY SSF56935 185 338 1.19E-86 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 SUPERFAMILY SSF56935 391 479 1.19E-86 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 SUPERFAMILY SSF56935 998 1086 1.19E-86 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 SUPERFAMILY SSF56935 916 958 1.19E-86 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 290 320 6.0E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Pfam PF13715 CarboxypepD_reg-like domain 108 189 3.9E-17 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Gene3D G3DSA:2.60.40.1120 107 192 7.0E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Pfam PF07715 TonB-dependent Receptor Plug Domain 198 314 5.3E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 107 1086 7.2E-235 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Gene3D G3DSA:2.170.130.10 193 314 9.4E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 PANTHER PTHR11532 646 1084 1.7E-213 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 PANTHER PTHR11532 537 614 1.7E-213 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 PANTHER PTHR11532 104 445 1.7E-213 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 SUPERFAMILY SSF49464 106 187 8.37E-19 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Gene3D G3DSA:2.40.170.20 315 354 1.6E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Gene3D G3DSA:2.40.170.20 989 1086 1.6E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Gene3D G3DSA:2.40.170.20 400 851 1.6E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 Gene3D G3DSA:2.40.170.20 886 948 1.6E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 PANTHER PTHR11532:SF57 646 1084 1.7E-213 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 PANTHER PTHR11532:SF57 537 614 1.7E-213 T 21-04-2016 SPH21_RS04910 d0bf448b62ce2bfd6b3a1275eaec14f0 1086 PANTHER PTHR11532:SF57 104 445 1.7E-213 T 21-04-2016 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 SMART SM00388 148 216 3.6E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 SUPERFAMILY SSF55874 206 370 3.27E-40 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 PANTHER PTHR24423 8 22 5.0E-60 T 21-04-2016 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 PANTHER PTHR24423 146 369 5.0E-60 T 21-04-2016 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 PRINTS PR00344 Bacterial sensor protein C-terminal signature 355 368 1.3E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 PRINTS PR00344 Bacterial sensor protein C-terminal signature 315 325 1.3E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 PRINTS PR00344 Bacterial sensor protein C-terminal signature 331 349 1.3E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 PRINTS PR00344 Bacterial sensor protein C-terminal signature 297 311 1.3E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 Pfam PF00512 His Kinase A (phospho-acceptor) domain 148 216 1.1E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 Gene3D G3DSA:3.30.565.10 217 375 1.4E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 SUPERFAMILY SSF47384 134 218 1.63E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 Gene3D G3DSA:3.40.50.2300 2 86 6.2E-4 T 21-04-2016 SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 SMART SM00387 259 371 7.1E-29 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 259 369 9.4E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26395 270bec4e1e9bca5dcc76f91ffb39e772 396 Gene3D G3DSA:1.10.287.130 140 212 2.0E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 Gene3D G3DSA:3.40.50.1100 39 136 5.0E-32 T 21-04-2016 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 6 277 1.8E-65 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 PANTHER PTHR10314 3 289 7.4E-132 T 21-04-2016 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 ProSitePatterns PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 29 47 - T 21-04-2016 IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site GO:0006535 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 Gene3D G3DSA:3.40.50.1100 2 38 7.4E-78 T 21-04-2016 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 Gene3D G3DSA:3.40.50.1100 142 288 7.4E-78 T 21-04-2016 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 SUPERFAMILY SSF53686 3 284 1.57E-86 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 PANTHER PTHR10314:SF100 3 289 7.4E-132 T 21-04-2016 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 TIGRFAM TIGR01136 cysKM: cysteine synthase 4 288 2.0E-107 T 21-04-2016 IPR005856 Cysteine synthase GO:0004124|GO:0006535 KEGG: 00270+2.5.1.47|KEGG: 00920+2.5.1.47|MetaCyc: PWY-6936|UniPathway: UPA00136 SPH21_RS20485 f2dacd9d481e945eb1e74cbf366d106e 289 TIGRFAM TIGR01138 cysM: cysteine synthase B 3 288 2.2E-123 T 21-04-2016 IPR005858 Cysteine synthase CysM GO:0004124|GO:0006535 KEGG: 00270+2.5.1.47|KEGG: 00920+2.5.1.47|MetaCyc: PWY-6936|UniPathway: UPA00136 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 PRINTS PR00762 Chloride channel signature 333 353 1.4E-11 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 PRINTS PR00762 Chloride channel signature 361 377 1.4E-11 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 PRINTS PR00762 Chloride channel signature 103 122 1.4E-11 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 PRINTS PR00762 Chloride channel signature 154 173 1.4E-11 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 Pfam PF00654 Voltage gated chloride channel 62 410 5.6E-67 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 PANTHER PTHR11689 98 349 2.3E-17 T 21-04-2016 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 SUPERFAMILY SSF81340 8 419 1.7E-80 T 21-04-2016 IPR014743 Chloride channel, core GO:0005216|GO:0055085 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 PANTHER PTHR11689:SF14 98 349 2.3E-17 T 21-04-2016 SPH21_RS00875 40d1e5e5794270bbee3057b0022dab43 427 Gene3D G3DSA:1.10.3080.10 13 418 2.6E-52 T 21-04-2016 IPR014743 Chloride channel, core GO:0005216|GO:0055085 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 SMART SM00342 232 315 6.9E-24 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 PANTHER PTHR11019:SF68 101 323 1.7E-49 T 21-04-2016 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 SUPERFAMILY SSF46689 268 319 1.25E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 SUPERFAMILY SSF46689 216 266 8.96E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 Gene3D G3DSA:1.10.10.60 269 318 1.3E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 PANTHER PTHR11019 101 323 1.7E-49 T 21-04-2016 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 Pfam PF01965 DJ-1/PfpI family 39 177 1.2E-13 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 SUPERFAMILY SSF52317 2 195 3.06E-31 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 Gene3D G3DSA:3.40.50.880 16 221 3.6E-41 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 Gene3D G3DSA:1.10.10.60 222 268 9.8E-19 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24855 d492c689746f5a43561859d4f09090c3 325 Pfam PF12833 Helix-turn-helix domain 238 316 2.9E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 SMART SM00354 5 78 4.1E-17 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 SUPERFAMILY SSF47413 4 67 1.34E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 Pfam PF13377 Periplasmic binding protein-like domain 176 337 2.6E-24 T 21-04-2016 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 Gene3D G3DSA:3.40.50.2300 178 316 5.3E-30 T 21-04-2016 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 Gene3D G3DSA:1.10.260.40 7 60 3.4E-19 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 Gene3D G3DSA:3.40.50.2300 61 177 7.3E-38 T 21-04-2016 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 SUPERFAMILY SSF53822 65 319 3.21E-50 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 55 1.5E-9 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS23660 62ff234c1e8f462a82166e3521f0ec8f 345 PANTHER PTHR30146 5 344 2.5E-87 T 21-04-2016 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 SUPERFAMILY SSF51905 10 337 3.37E-22 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 TIGRFAM TIGR01320 mal_quin_oxido: malate dehydrogenase (acceptor) 13 494 2.6E-230 T 21-04-2016 IPR006231 Malate:quinone-oxidoreductase GO:0006099|GO:0008924 KEGG: 00020+1.1.5.4|KEGG: 00620+1.1.5.4|MetaCyc: PWY-7254|UniPathway: UPA00223 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 Gene3D G3DSA:3.50.50.60 153 334 2.1E-16 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 Gene3D G3DSA:3.50.50.60 12 103 2.1E-16 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 Pfam PF06039 Malate:quinone oxidoreductase (Mqo) 11 496 6.9E-246 T 21-04-2016 IPR006231 Malate:quinone-oxidoreductase GO:0006099|GO:0008924 KEGG: 00020+1.1.5.4|KEGG: 00620+1.1.5.4|MetaCyc: PWY-7254|UniPathway: UPA00223 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 Hamap MF_00212 Probable malate:quinone oxidoreductase [mqo]. 8 496 53.896 T 21-04-2016 IPR006231 Malate:quinone-oxidoreductase GO:0006099|GO:0008924 KEGG: 00020+1.1.5.4|KEGG: 00620+1.1.5.4|MetaCyc: PWY-7254|UniPathway: UPA00223 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 PANTHER PTHR13847:SF214 10 447 7.7E-200 T 21-04-2016 SPH21_RS11085 09567c25dda5b75a65bd3d7185b05b3b 504 PANTHER PTHR13847 10 447 7.7E-200 T 21-04-2016 SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 91 4.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 4.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 4.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 4.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 4.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 4.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 SUPERFAMILY SSF51735 3 248 1.85E-72 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 Gene3D G3DSA:3.40.50.720 2 248 3.2E-73 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 10 248 2.8E-55 T 21-04-2016 SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PANTHER PTHR24322 158 190 2.7E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PANTHER PTHR24322 8 141 2.7E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 1.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 80 91 1.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22675 9882c8867a238cf5c56be329b25d1767 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 145 1.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PANTHER PTHR10617 60 372 1.0E-141 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PANTHER PTHR10617 453 507 1.0E-141 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PIRSF PIRSF038984 2 514 1.2E-187 T 21-04-2016 IPR028348 FAD dependent protein SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PANTHER PTHR10617:SF52 60 372 1.0E-141 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PANTHER PTHR10617:SF52 453 507 1.0E-141 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 239 257 4.6E-6 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 84 103 4.6E-6 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 Gene3D G3DSA:3.50.50.60 84 272 2.6E-33 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 Gene3D G3DSA:3.50.50.60 424 511 2.6E-33 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 Pfam PF03486 HI0933-like protein 84 248 2.2E-8 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 83 105 8.2E-7 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 242 251 8.2E-7 T 21-04-2016 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 SUPERFAMILY SSF51905 462 511 1.48E-35 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS03620 48d787b395fd13f0be134117e9ce4096 515 SUPERFAMILY SSF51905 83 270 1.48E-35 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18675 5d96d2d0a45cdc1ba8acb8d0c7c387f7 240 SUPERFAMILY SSF53790 2 235 9.29E-63 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS18675 5d96d2d0a45cdc1ba8acb8d0c7c387f7 240 PANTHER PTHR21091 5 232 2.2E-57 T 21-04-2016 SPH21_RS18675 5d96d2d0a45cdc1ba8acb8d0c7c387f7 240 Gene3D G3DSA:3.30.950.10 120 236 6.7E-26 T 21-04-2016 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 SPH21_RS18675 5d96d2d0a45cdc1ba8acb8d0c7c387f7 240 PANTHER PTHR21091:SF16 5 232 2.2E-57 T 21-04-2016 SPH21_RS18675 5d96d2d0a45cdc1ba8acb8d0c7c387f7 240 Gene3D G3DSA:3.40.1010.10 4 119 9.1E-39 T 21-04-2016 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 SPH21_RS18675 5d96d2d0a45cdc1ba8acb8d0c7c387f7 240 TIGRFAM TIGR01469 cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase 5 237 7.4E-78 T 21-04-2016 IPR006366 Uroporphyrin-III C-methyltransferase GO:0006779|GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS18675 5d96d2d0a45cdc1ba8acb8d0c7c387f7 240 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 5 214 6.8E-43 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 PRINTS PR01438 Universal stress protein signature 117 129 5.6E-16 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 PRINTS PR01438 Universal stress protein signature 10 28 5.6E-16 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 PRINTS PR01438 Universal stress protein signature 135 157 5.6E-16 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 PANTHER PTHR31964 9 161 2.4E-32 T 21-04-2016 SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 PIRSF PIRSF006276 9 160 4.3E-18 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 Pfam PF00582 Universal stress protein family 11 157 1.4E-35 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 PANTHER PTHR31964:SF26 9 161 2.4E-32 T 21-04-2016 SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 SUPERFAMILY SSF52402 11 159 1.26E-36 T 21-04-2016 SPH21_RS14945 99db537f074794ac07d57aa06b3f18b9 163 Gene3D G3DSA:3.40.50.620 11 159 2.3E-37 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 PRINTS PR00344 Bacterial sensor protein C-terminal signature 384 397 3.2E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 PRINTS PR00344 Bacterial sensor protein C-terminal signature 359 377 3.2E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 PRINTS PR00344 Bacterial sensor protein C-terminal signature 324 338 3.2E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 PRINTS PR00344 Bacterial sensor protein C-terminal signature 342 352 3.2E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 Pfam PF13185 GAF domain 31 160 1.0E-7 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 SUPERFAMILY SSF55874 231 398 6.94E-37 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 287 399 9.3E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 Gene3D G3DSA:3.30.450.40 32 158 3.2E-9 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 SMART SM00388 176 242 4.1E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 Gene3D G3DSA:1.10.287.130 172 237 2.6E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 PANTHER PTHR24423 107 400 1.9E-60 T 21-04-2016 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 PANTHER PTHR24423 5 33 1.9E-60 T 21-04-2016 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 SMART SM00387 287 400 1.7E-29 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 SUPERFAMILY SSF55781 32 165 9.65E-20 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 Gene3D G3DSA:3.30.565.10 243 400 7.2E-38 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 Pfam PF00512 His Kinase A (phospho-acceptor) domain 178 242 1.7E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15470 8dee9298d1449fa4059d7a2262121cb8 401 SUPERFAMILY SSF47384 169 243 1.45E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15505 5afaaf14cfed8c45433fe39a962d6380 203 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 132 198 9.4E-14 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS15505 5afaaf14cfed8c45433fe39a962d6380 203 Gene3D G3DSA:3.40.50.1000 102 198 3.4E-33 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS15505 5afaaf14cfed8c45433fe39a962d6380 203 Gene3D G3DSA:3.40.50.1000 13 34 3.4E-33 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS15505 5afaaf14cfed8c45433fe39a962d6380 203 Pfam PF13419 Haloacid dehalogenase-like hydrolase 23 199 2.0E-24 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS15505 5afaaf14cfed8c45433fe39a962d6380 203 PANTHER PTHR18901 19 198 1.6E-43 T 21-04-2016 SPH21_RS15505 5afaaf14cfed8c45433fe39a962d6380 203 SUPERFAMILY SSF56784 19 199 8.83E-42 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS15505 5afaaf14cfed8c45433fe39a962d6380 203 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 108 175 6.8E-6 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS16830 dfccdbed0441ce0011fdaa3ce9683896 180 PANTHER PTHR13256 7 144 1.4E-12 T 21-04-2016 SPH21_RS16830 dfccdbed0441ce0011fdaa3ce9683896 180 Gene3D G3DSA:3.40.630.30 3 152 1.1E-21 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS16830 dfccdbed0441ce0011fdaa3ce9683896 180 Pfam PF13302 Acetyltransferase (GNAT) domain 9 144 3.0E-15 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS16830 dfccdbed0441ce0011fdaa3ce9683896 180 SUPERFAMILY SSF55729 3 144 5.05E-22 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS01445 c0f0723d439a9af7496048e113dd4e75 551 SUPERFAMILY SSF52540 1 329 9.68E-28 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01445 c0f0723d439a9af7496048e113dd4e75 551 Gene3D G3DSA:3.40.50.300 1 349 1.4E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01445 c0f0723d439a9af7496048e113dd4e75 551 Pfam PF13175 AAA ATPase domain 105 327 1.1E-18 T 21-04-2016 SPH21_RS01445 c0f0723d439a9af7496048e113dd4e75 551 PANTHER PTHR32182 1 49 5.4E-15 T 21-04-2016 SPH21_RS00685 a2f5e34478f0a6a693c1a6829a148d65 665 Pfam PF00593 TonB dependent receptor 432 664 6.6E-24 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00685 a2f5e34478f0a6a693c1a6829a148d65 665 Gene3D G3DSA:2.170.130.10 45 147 1.5E-27 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00685 a2f5e34478f0a6a693c1a6829a148d65 665 SUPERFAMILY SSF56935 46 665 1.01E-93 T 21-04-2016 SPH21_RS00685 a2f5e34478f0a6a693c1a6829a148d65 665 Pfam PF07715 TonB-dependent Receptor Plug Domain 44 144 3.2E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00685 a2f5e34478f0a6a693c1a6829a148d65 665 PANTHER PTHR32552 45 665 3.4E-38 T 21-04-2016 SPH21_RS00685 a2f5e34478f0a6a693c1a6829a148d65 665 Gene3D G3DSA:2.40.170.20 148 665 3.3E-68 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 Pfam PF01202 Shikimate kinase 12 159 1.9E-41 T 21-04-2016 IPR031322 Shikimate kinase/gluconokinase KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 Hamap MF_00109 Shikimate kinase [aroK]. 3 169 23.625 T 21-04-2016 IPR000623 Shikimate kinase/Threonine synthase-like 1 KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 PANTHER PTHR21087:SF0 3 168 9.4E-51 T 21-04-2016 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 SUPERFAMILY SSF52540 3 166 5.65E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 PANTHER PTHR21087 3 168 9.4E-51 T 21-04-2016 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 Gene3D G3DSA:3.40.50.300 3 168 7.6E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 PRINTS PR01100 Shikimate kinase family signature 76 85 2.7E-20 T 21-04-2016 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 PRINTS PR01100 Shikimate kinase family signature 97 114 2.7E-20 T 21-04-2016 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 PRINTS PR01100 Shikimate kinase family signature 58 66 2.7E-20 T 21-04-2016 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 PRINTS PR01100 Shikimate kinase family signature 6 21 2.7E-20 T 21-04-2016 SPH21_RS25875 5237e8f73ec115f6709e578d9956093c 170 PRINTS PR01100 Shikimate kinase family signature 30 43 2.7E-20 T 21-04-2016 SPH21_RS13885 a54be2f6b9a6dc95a55fd2a2b6b77ba7 534 TIGRFAM TIGR00831 a_cpa1: Na+/H+ antiporter 9 532 1.1E-105 T 21-04-2016 IPR004705 Cation/H+ exchanger, CPA1 family, bacteria GO:0006812|GO:0015299|GO:0016021 SPH21_RS13885 a54be2f6b9a6dc95a55fd2a2b6b77ba7 534 PANTHER PTHR10110 7 531 4.3E-88 T 21-04-2016 IPR018422 Cation/H+ exchanger, CPA1 family GO:0006812|GO:0015299|GO:0016021 Reactome: REACT_15518 SPH21_RS13885 a54be2f6b9a6dc95a55fd2a2b6b77ba7 534 PANTHER PTHR10110:SF86 7 531 4.3E-88 T 21-04-2016 SPH21_RS13885 a54be2f6b9a6dc95a55fd2a2b6b77ba7 534 Pfam PF00999 Sodium/hydrogen exchanger family 11 408 2.8E-53 T 21-04-2016 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 SUPERFAMILY SSF46894 142 209 8.84E-19 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 SMART SM00448 2 115 3.1E-23 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 SUPERFAMILY SSF52172 1 128 2.56E-30 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 Pfam PF00072 Response regulator receiver domain 5 116 1.0E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 SMART SM00421 146 203 1.4E-15 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 149 163 1.6E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 179 191 1.6E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 163 179 1.6E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 PANTHER PTHR26402 2 194 5.9E-49 T 21-04-2016 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 Gene3D G3DSA:3.40.50.2300 1 153 4.4E-32 T 21-04-2016 SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 Gene3D G3DSA:1.10.10.10 154 208 4.0E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15965 ef958bc4833ae93c4a2b81a34920f857 209 Pfam PF00196 Bacterial regulatory proteins, luxR family 148 200 2.8E-16 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 2.0E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 2.0E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 223 243 2.0E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 2.0E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 2.0E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 14 31 2.0E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 1.6E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 1.6E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 1.6E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 142 170 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PANTHER PTHR24322 155 187 2.5E-39 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 PANTHER PTHR24322 17 138 2.5E-39 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 Gene3D G3DSA:3.40.50.720 7 259 7.6E-71 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 SUPERFAMILY SSF51735 12 259 2.41E-69 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22025 e71a4329601b726633aa6c0cac5c252e 263 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 22 258 8.6E-46 T 21-04-2016 SPH21_RS19865 5ee3cc4dfce5fee587ba7d2bf6c00af5 204 SUPERFAMILY SSF52540 8 196 3.61E-30 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19865 5ee3cc4dfce5fee587ba7d2bf6c00af5 204 PANTHER PTHR10695 10 198 1.5E-41 T 21-04-2016 SPH21_RS19865 5ee3cc4dfce5fee587ba7d2bf6c00af5 204 Hamap MF_00376 Dephospho-CoA kinase [coaE]. 7 200 23.337 T 21-04-2016 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24|UniPathway: UPA00241 SPH21_RS19865 5ee3cc4dfce5fee587ba7d2bf6c00af5 204 Gene3D G3DSA:3.40.50.300 7 199 1.3E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19865 5ee3cc4dfce5fee587ba7d2bf6c00af5 204 Pfam PF01121 Dephospho-CoA kinase 10 182 6.6E-46 T 21-04-2016 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24|UniPathway: UPA00241 SPH21_RS19865 5ee3cc4dfce5fee587ba7d2bf6c00af5 204 TIGRFAM TIGR00152 TIGR00152: dephospho-CoA kinase 10 183 5.8E-44 T 21-04-2016 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24|UniPathway: UPA00241 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Gene3D G3DSA:2.40.170.20 449 514 1.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Gene3D G3DSA:2.40.170.20 1065 1172 1.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Gene3D G3DSA:2.40.170.20 554 951 1.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Gene3D G3DSA:2.40.170.20 1004 1029 1.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Gene3D G3DSA:2.40.170.20 321 341 1.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 SUPERFAMILY SSF56935 571 920 6.41E-97 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 SUPERFAMILY SSF56935 995 1039 6.41E-97 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 SUPERFAMILY SSF56935 201 344 6.41E-97 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 SUPERFAMILY SSF56935 1077 1172 6.41E-97 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 SUPERFAMILY SSF56935 440 529 6.41E-97 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 PANTHER PTHR11532 643 1170 1.1E-246 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 PANTHER PTHR11532 121 532 1.1E-246 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Pfam PF07715 TonB-dependent Receptor Plug Domain 215 320 6.4E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 PANTHER PTHR11532:SF57 643 1170 1.1E-246 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 PANTHER PTHR11532:SF57 121 532 1.1E-246 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Pfam PF13715 CarboxypepD_reg-like domain 125 207 2.3E-19 T 21-04-2016 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 296 326 1.3E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Gene3D G3DSA:2.60.40.1120 125 209 1.8E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 124 1172 6.1E-261 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 SUPERFAMILY SSF49464 123 205 6.54E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14630 cd391c5a490c71136f3df21f7419888b 1172 Gene3D G3DSA:2.170.130.10 210 320 4.1E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Gene3D G3DSA:2.60.40.1120 36 123 7.7E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Gene3D G3DSA:2.40.170.20 256 276 3.6E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Gene3D G3DSA:2.40.170.20 332 796 3.6E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Gene3D G3DSA:2.40.170.20 952 1031 3.6E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Gene3D G3DSA:2.40.170.20 867 913 3.6E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Pfam PF07715 TonB-dependent Receptor Plug Domain 125 252 1.6E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Gene3D G3DSA:2.170.130.10 125 255 2.3E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532 5 199 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532 577 1029 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532 219 435 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532 517 546 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532:SF57 5 199 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532:SF57 577 1029 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532:SF57 219 435 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 PANTHER PTHR11532:SF57 517 546 6.4E-256 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 35 1031 6.5E-272 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 SUPERFAMILY SSF56935 858 902 3.15E-102 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 SUPERFAMILY SSF56935 323 411 3.15E-102 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 SUPERFAMILY SSF56935 446 787 3.15E-102 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 SUPERFAMILY SSF56935 942 1031 3.15E-102 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 SUPERFAMILY SSF56935 113 276 3.15E-102 T 21-04-2016 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 228 258 6.4E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 SUPERFAMILY SSF49464 34 115 9.29E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS24920 41766ca7e4d4ed650db1c4e14095fb94 1031 Pfam PF13715 CarboxypepD_reg-like domain 36 117 1.3E-15 T 21-04-2016 SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 TIGRFAM TIGR01067 rplN_bact: ribosomal protein uL14 1 122 4.4E-58 T 21-04-2016 IPR005745 Ribosomal protein L14P, bacterial-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 Hamap MF_01367 50S ribosomal protein L14 [rplN]. 1 122 26.698 T 21-04-2016 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 SMART SM01374 1 122 3.9E-88 T 21-04-2016 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 PANTHER PTHR11761 1 122 5.4E-75 T 21-04-2016 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 Pfam PF00238 Ribosomal protein L14p/L23e 1 122 8.7E-56 T 21-04-2016 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 Gene3D G3DSA:2.40.150.20 1 122 1.0E-54 T 21-04-2016 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 ProSitePatterns PS00049 Ribosomal protein L14 signature. 60 86 - T 21-04-2016 IPR019972 Ribosomal protein L14P, conserved site SPH21_RS08545 424cf63d9a7afca8a6469969e2ad785c 122 SUPERFAMILY SSF50193 1 122 7.33E-51 T 21-04-2016 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SPH21_RS18040 7332cba72243b6c45ee9efeaac6c86a6 392 Pfam PF01790 Prolipoprotein diacylglyceryl transferase 114 375 7.3E-39 T 21-04-2016 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 UniPathway: UPA00664 SPH21_RS18040 7332cba72243b6c45ee9efeaac6c86a6 392 PANTHER PTHR30589 113 392 2.1E-35 T 21-04-2016 SPH21_RS18040 7332cba72243b6c45ee9efeaac6c86a6 392 PANTHER PTHR30589:SF0 113 392 2.1E-35 T 21-04-2016 SPH21_RS11585 151959ad68c188518314540fa12f17d2 471 Pfam PF03629 Carbohydrate esterase, sialic acid-specific acetylesterase 103 362 3.5E-85 T 21-04-2016 IPR005181 Sialate O-acetylesterase domain SPH21_RS11585 151959ad68c188518314540fa12f17d2 471 PANTHER PTHR22901 1 471 2.1E-161 T 21-04-2016 SPH21_RS11585 151959ad68c188518314540fa12f17d2 471 PANTHER PTHR22901:SF0 1 471 2.1E-161 T 21-04-2016 SPH21_RS11585 151959ad68c188518314540fa12f17d2 471 SUPERFAMILY SSF52266 102 422 3.66E-72 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS26205 139dfdb0e62a4effbcec4554f47c2d75 695 Pfam PF03629 Carbohydrate esterase, sialic acid-specific acetylesterase 144 230 3.8E-8 T 21-04-2016 IPR005181 Sialate O-acetylesterase domain SPH21_RS26205 139dfdb0e62a4effbcec4554f47c2d75 695 PANTHER PTHR30383:SF6 310 492 3.3E-15 T 21-04-2016 SPH21_RS26205 139dfdb0e62a4effbcec4554f47c2d75 695 Gene3D G3DSA:3.40.50.1110 309 497 7.9E-18 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS26205 139dfdb0e62a4effbcec4554f47c2d75 695 PANTHER PTHR30383 310 492 3.3E-15 T 21-04-2016 SPH21_RS26205 139dfdb0e62a4effbcec4554f47c2d75 695 Gene3D G3DSA:3.40.50.1110 124 268 2.9E-4 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS26205 139dfdb0e62a4effbcec4554f47c2d75 695 SUPERFAMILY SSF52266 24 273 5.64E-32 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS26205 139dfdb0e62a4effbcec4554f47c2d75 695 SUPERFAMILY SSF52266 308 498 4.33E-18 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 Gene3D G3DSA:3.40.50.300 355 586 8.8E-74 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 PANTHER PTHR24222 27 592 6.0E-164 T 21-04-2016 SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 PANTHER PTHR24222:SF24 27 592 6.0E-164 T 21-04-2016 SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 SUPERFAMILY SSF90123 25 348 3.79E-45 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 Pfam PF00664 ABC transporter transmembrane region 40 303 1.6E-22 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 Gene3D G3DSA:1.20.1560.10 27 340 5.8E-36 T 21-04-2016 SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 Pfam PF00005 ABC transporter 373 521 4.7E-30 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 SUPERFAMILY SSF52540 347 592 1.93E-84 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 ProSitePatterns PS00211 ABC transporters family signature. 493 507 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS21935 51fd40ed4d1aa1d0d17f620eb5ebb1ba 594 SMART SM00382 381 567 2.1E-15 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 Gene3D G3DSA:1.10.390.10 419 561 9.4E-13 T 21-04-2016 SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 PANTHER PTHR11533 212 253 1.5E-33 T 21-04-2016 IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase GO:0006508 SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 PANTHER PTHR11533 285 560 1.5E-33 T 21-04-2016 IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase GO:0006508 SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 PANTHER PTHR11533 46 195 1.5E-33 T 21-04-2016 IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase GO:0006508 SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 SUPERFAMILY SSF55486 335 561 1.76E-31 T 21-04-2016 SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 PANTHER PTHR11533:SF163 212 253 1.5E-33 T 21-04-2016 SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 PANTHER PTHR11533:SF163 285 560 1.5E-33 T 21-04-2016 SPH21_RS22465 eab34eed635eee5b1a94651c73dec012 656 PANTHER PTHR11533:SF163 46 195 1.5E-33 T 21-04-2016 SPH21_RS09195 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 19 198 2.0E-38 T 21-04-2016 SPH21_RS09195 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 217 358 2.0E-38 T 21-04-2016 SPH21_RS09195 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF01548 Transposase 23 169 4.2E-7 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS09195 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF02371 Transposase IS116/IS110/IS902 family 240 319 5.2E-24 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS09195 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 19 198 2.0E-38 T 21-04-2016 SPH21_RS09195 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 217 358 2.0E-38 T 21-04-2016 SPH21_RS02390 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 19 198 2.0E-38 T 21-04-2016 SPH21_RS02390 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 217 358 2.0E-38 T 21-04-2016 SPH21_RS02390 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF01548 Transposase 23 169 4.2E-7 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS02390 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF02371 Transposase IS116/IS110/IS902 family 240 319 5.2E-24 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS02390 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 19 198 2.0E-38 T 21-04-2016 SPH21_RS02390 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 217 358 2.0E-38 T 21-04-2016 SPH21_RS16920 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 19 198 2.0E-38 T 21-04-2016 SPH21_RS16920 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 217 358 2.0E-38 T 21-04-2016 SPH21_RS16920 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF01548 Transposase 23 169 4.2E-7 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS16920 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF02371 Transposase IS116/IS110/IS902 family 240 319 5.2E-24 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS16920 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 19 198 2.0E-38 T 21-04-2016 SPH21_RS16920 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 217 358 2.0E-38 T 21-04-2016 SPH21_RS08175 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 19 198 2.0E-38 T 21-04-2016 SPH21_RS08175 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055 217 358 2.0E-38 T 21-04-2016 SPH21_RS08175 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF01548 Transposase 23 169 4.2E-7 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS08175 4b8df093b43d6f1d12ca0e188f7463f6 363 Pfam PF02371 Transposase IS116/IS110/IS902 family 240 319 5.2E-24 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS08175 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 19 198 2.0E-38 T 21-04-2016 SPH21_RS08175 4b8df093b43d6f1d12ca0e188f7463f6 363 PANTHER PTHR33055:SF3 217 358 2.0E-38 T 21-04-2016 SPH21_RS20265 28764f8af3b5b4e76dfa6fb4f2064a48 305 Pfam PF13437 HlyD family secretion protein 180 284 8.3E-12 T 21-04-2016 SPH21_RS20265 28764f8af3b5b4e76dfa6fb4f2064a48 305 PANTHER PTHR32347:SF14 25 295 5.4E-29 T 21-04-2016 SPH21_RS20265 28764f8af3b5b4e76dfa6fb4f2064a48 305 Gene3D G3DSA:2.40.50.100 38 68 6.9E-8 T 21-04-2016 SPH21_RS20265 28764f8af3b5b4e76dfa6fb4f2064a48 305 Gene3D G3DSA:2.40.50.100 175 207 6.9E-8 T 21-04-2016 SPH21_RS20265 28764f8af3b5b4e76dfa6fb4f2064a48 305 SUPERFAMILY SSF111369 30 272 1.96E-8 T 21-04-2016 SPH21_RS20265 28764f8af3b5b4e76dfa6fb4f2064a48 305 PANTHER PTHR32347 25 295 5.4E-29 T 21-04-2016 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 PANTHER PTHR10851:SF0 1 217 2.6E-110 T 21-04-2016 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 Gene3D G3DSA:2.30.110.10 19 217 1.5E-84 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 SUPERFAMILY SSF50475 19 217 4.68E-67 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 ProSitePatterns PS01064 Pyridoxamine 5'-phosphate oxidase signature. 185 198 - T 21-04-2016 IPR019740 Pyridoxamine 5'-phosphate oxidase, conserved site GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 Pfam PF10590 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region 175 217 6.8E-20 T 21-04-2016 IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 36 120 1.5E-24 T 21-04-2016 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 PANTHER PTHR10851 1 217 2.6E-110 T 21-04-2016 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 PIRSF PIRSF000190 2 217 5.6E-82 T 21-04-2016 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 Hamap MF_01629 Pyridoxine/pyridoxamine 5'-phosphate oxidase [pdxH]. 13 217 39.476 T 21-04-2016 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS16645 b18a06c2e638dd8a420b7c152ad03a37 217 TIGRFAM TIGR00558 pdxH: pyridoxamine 5'-phosphate oxidase 3 217 5.2E-90 T 21-04-2016 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS08520 67e8e9fafcf913a0ec5d7de1cab4a012 144 Pfam PF00237 Ribosomal protein L22p/L17e 34 135 1.9E-26 T 21-04-2016 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08520 67e8e9fafcf913a0ec5d7de1cab4a012 144 TIGRFAM TIGR01044 rplV_bact: ribosomal protein uL22 35 135 4.1E-27 T 21-04-2016 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS08520 67e8e9fafcf913a0ec5d7de1cab4a012 144 Gene3D G3DSA:3.90.470.10 29 140 7.8E-35 T 21-04-2016 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08520 67e8e9fafcf913a0ec5d7de1cab4a012 144 SUPERFAMILY SSF54843 20 138 5.49E-34 T 21-04-2016 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08520 67e8e9fafcf913a0ec5d7de1cab4a012 144 PANTHER PTHR13501 30 135 4.9E-32 T 21-04-2016 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS08520 67e8e9fafcf913a0ec5d7de1cab4a012 144 Hamap MF_01331_B 50S ribosomal protein L22 [rplV]. 26 138 23.493 T 21-04-2016 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 PANTHER PTHR11019 28 305 2.2E-35 T 21-04-2016 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 SMART SM00342 219 302 5.1E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 SUPERFAMILY SSF46689 257 305 9.86E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 Pfam PF12833 Helix-turn-helix domain 225 303 1.1E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 Gene3D G3DSA:1.10.10.60 195 252 3.7E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 PANTHER PTHR11019:SF50 28 305 2.2E-35 T 21-04-2016 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 Gene3D G3DSA:1.10.10.60 257 304 4.4E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04470 92c35c46de7478067d998967598ca560 306 Pfam PF02311 AraC-like ligand binding domain 48 159 1.9E-4 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS12750 2463b08b2e110c9d22ff95f75d2391ae 380 PANTHER PTHR34219 2 371 1.0E-61 T 21-04-2016 SPH21_RS12750 2463b08b2e110c9d22ff95f75d2391ae 380 Pfam PF03929 PepSY-associated TM region 12 361 8.1E-49 T 21-04-2016 IPR005625 PepSY-associated TM protein SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 Pfam PF01926 50S ribosome-binding GTPase 165 286 8.4E-22 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 PANTHER PTHR11702 1 332 1.1E-141 T 21-04-2016 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 Gene3D G3DSA:3.40.50.300 164 330 2.2E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 166 186 1.9E-34 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 215 230 1.9E-34 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 232 250 1.9E-34 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 187 205 1.9E-34 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 SUPERFAMILY SSF52540 156 330 3.45E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 Gene3D G3DSA:2.70.210.12 6 160 8.5E-51 T 21-04-2016 IPR006169 GTP1/OBG domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 ProSitePatterns PS00905 GTP1/OBG family signature. 217 230 - T 21-04-2016 IPR006074 GTP1/OBG, conserved site GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 Hamap MF_01454 GTPase Obg [obg]. 6 331 43.725 T 21-04-2016 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 Pfam PF01018 GTP1/OBG 7 162 1.4E-54 T 21-04-2016 IPR006169 GTP1/OBG domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 SUPERFAMILY SSF82051 6 162 4.71E-49 T 21-04-2016 IPR006169 GTP1/OBG domain GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 TIGRFAM TIGR02729 Obg_CgtA: Obg family GTPase CgtA 7 330 2.7E-125 T 21-04-2016 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 PIRSF PIRSF002401 4 332 7.6E-125 T 21-04-2016 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 SPH21_RS00375 1ab89ba9b9428d5cb27cf1d23874e6f9 332 PANTHER PTHR11702:SF3 1 332 1.1E-141 T 21-04-2016 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 Pfam PF13090 Polyphosphate kinase C-terminal domain 334 679 4.5E-144 T 21-04-2016 IPR025200 Polyphosphate kinase C-terminal domain KEGG: 00190+2.7.4.1 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 PIRSF PIRSF015589 1 689 1.9E-237 T 21-04-2016 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 PANTHER PTHR30218:SF0 2 686 4.5E-280 T 21-04-2016 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 Gene3D G3DSA:3.30.870.10 502 688 2.8E-69 T 21-04-2016 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 TIGRFAM TIGR03705 poly_P_kin: polyphosphate kinase 1 11 679 1.8E-234 T 21-04-2016 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 SUPERFAMILY SSF56024 322 492 2.04E-49 T 21-04-2016 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 Gene3D G3DSA:3.30.870.10 323 499 1.3E-62 T 21-04-2016 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 SUPERFAMILY SSF140356 10 112 2.88E-33 T 21-04-2016 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 SUPERFAMILY SSF56024 505 686 7.63E-69 T 21-04-2016 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 Pfam PF02503 Polyphosphate kinase middle domain 128 322 3.0E-43 T 21-04-2016 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 SUPERFAMILY SSF143724 114 317 2.16E-51 T 21-04-2016 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 PANTHER PTHR30218 2 686 4.5E-280 T 21-04-2016 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 Pfam PF13089 Polyphosphate kinase N-terminal domain 12 117 2.2E-35 T 21-04-2016 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 SPH21_RS15780 d4effe451ccb5f24b2f8ea805dbe3cf7 689 Gene3D G3DSA:3.30.1840.10 113 304 7.3E-49 T 21-04-2016 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 SPH21_RS07190 946b6497ea0bbe3be3df2450a279df20 161 SUPERFAMILY SSF109854 21 149 5.31E-15 T 21-04-2016 SPH21_RS07190 946b6497ea0bbe3be3df2450a279df20 161 Gene3D G3DSA:1.20.120.450 26 147 2.4E-12 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS07190 946b6497ea0bbe3be3df2450a279df20 161 Pfam PF12867 DinB superfamily 27 147 5.1E-8 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 ProSitePatterns PS00438 Catalase proximal active site signature. 44 60 - T 21-04-2016 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 Gene3D G3DSA:2.40.180.10 2 357 1.1E-185 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 Pfam PF06628 Catalase-related immune-responsive 419 483 5.7E-21 T 21-04-2016 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PIRSF PIRSF038928 1 489 1.0E-220 T 21-04-2016 IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PRINTS PR00067 Catalase signature 105 122 6.6E-72 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PRINTS PR00067 Catalase signature 289 316 6.6E-72 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PRINTS PR00067 Catalase signature 321 347 6.6E-72 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PRINTS PR00067 Catalase signature 124 142 6.6E-72 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PRINTS PR00067 Catalase signature 84 102 6.6E-72 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PRINTS PR00067 Catalase signature 21 44 6.6E-72 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 Pfam PF00199 Catalase 8 389 4.6E-199 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 SUPERFAMILY SSF56634 3 490 6.15E-213 T 21-04-2016 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 SMART SM01060 8 392 1.0E-287 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07585 4268a51ebca35657dd69642e4b9b93b1 498 PANTHER PTHR11465 7 485 2.9E-299 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 Gene3D G3DSA:3.90.70.10 8 133 7.8E-21 T 21-04-2016 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 SMART SM00382 501 688 3.4E-16 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 TIGRFAM TIGR01193 bacteriocin_ABC: ABC-type bacteriocin transporter 7 710 1.3E-158 T 21-04-2016 IPR005897 Peptidase C39, ABC-type bacteriocin transporter GO:0008234|GO:0016020|GO:0022885|GO:0043213 KEGG: 00900+3.4.22.- SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 Pfam PF00664 ABC transporter transmembrane region 164 431 5.8E-44 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 ProSitePatterns PS00211 ABC transporters family signature. 613 627 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 SUPERFAMILY SSF52540 471 713 1.11E-79 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 Gene3D G3DSA:3.40.50.300 476 703 3.7E-76 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 SUPERFAMILY SSF90123 149 460 2.62E-66 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 Pfam PF00005 ABC transporter 493 641 5.1E-33 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 Pfam PF03412 Peptidase C39 family 3 135 2.3E-32 T 21-04-2016 IPR005074 Peptidase C39, bacteriocin processing GO:0005524|GO:0006508|GO:0008233|GO:0016021 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 Gene3D G3DSA:1.20.1560.10 149 458 2.7E-70 T 21-04-2016 SPH21_RS20335 1548471c4ecd6bb2e7bc61318dfdac37 721 PANTHER PTHR24221 149 716 1.9E-185 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 SUPERFAMILY SSF56954 6 471 3.66E-93 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 Gene3D G3DSA:2.20.200.10 101 146 2.3E-10 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 Gene3D G3DSA:2.20.200.10 319 354 2.3E-10 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 PANTHER PTHR30203 41 471 1.1E-94 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 TIGRFAM TIGR01845 outer_NodT: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family 16 470 2.0E-85 T 21-04-2016 IPR010131 RND efflux system, outer membrane lipoprotein, NodT GO:0005215|GO:0006810|GO:0008289|GO:0016020 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 PANTHER PTHR30203:SF14 41 471 1.1E-94 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 Pfam PF02321 Outer membrane efflux protein 286 468 3.5E-21 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 Pfam PF02321 Outer membrane efflux protein 64 259 7.4E-29 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 Gene3D G3DSA:1.20.1600.10 357 471 3.7E-93 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 Gene3D G3DSA:1.20.1600.10 54 90 3.7E-93 T 21-04-2016 SPH21_RS14055 ed85958909f3e5210e0f4987d90a1e26 471 Gene3D G3DSA:1.20.1600.10 147 318 3.7E-93 T 21-04-2016 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 SUPERFAMILY SSF46689 270 320 6.72E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 PANTHER PTHR11019 74 325 1.4E-51 T 21-04-2016 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 SMART SM00342 234 317 1.7E-26 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 Gene3D G3DSA:3.40.50.880 32 223 3.2E-37 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 PANTHER PTHR11019:SF68 74 325 1.4E-51 T 21-04-2016 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 SUPERFAMILY SSF46689 219 268 5.82E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 Gene3D G3DSA:1.10.10.60 271 320 1.0E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 Pfam PF01965 DJ-1/PfpI family 38 179 2.1E-14 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 Gene3D G3DSA:1.10.10.60 224 270 1.6E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 Pfam PF12833 Helix-turn-helix domain 240 317 3.8E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 SUPERFAMILY SSF52317 41 198 4.89E-32 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 301 317 9.1E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS18330 3efaf41ed2800a00e026e1360b107df0 326 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 286 301 9.1E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 SMART SM00421 147 204 2.3E-13 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 SUPERFAMILY SSF52172 7 133 1.85E-12 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 PANTHER PTHR26402 5 205 2.0E-21 T 21-04-2016 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 SUPERFAMILY SSF46894 146 210 7.82E-15 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 Pfam PF00196 Bacterial regulatory proteins, luxR family 150 204 5.6E-14 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 Gene3D G3DSA:1.10.10.10 126 210 4.8E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 Pfam PF00072 Response regulator receiver domain 9 120 4.5E-9 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 180 192 5.5E-7 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 164 180 5.5E-7 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 150 164 5.5E-7 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20845 3cac73ec234a80e580a9baec4de37729 210 Gene3D G3DSA:3.40.50.2300 10 125 6.0E-12 T 21-04-2016 SPH21_RS02335 9b5c0181c4ae3913dc816925c3b6d02f 360 SUPERFAMILY SSF75005 55 333 8.64E-23 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02335 9b5c0181c4ae3913dc816925c3b6d02f 360 Pfam PF04616 Glycosyl hydrolases family 43 126 210 1.4E-7 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02335 9b5c0181c4ae3913dc816925c3b6d02f 360 Gene3D G3DSA:2.115.10.20 114 220 4.4E-14 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS21220 311b889e797a44a2aaf9fdb9d4cf4e0a 471 PANTHER PTHR22901 1 469 1.6E-140 T 21-04-2016 SPH21_RS21220 311b889e797a44a2aaf9fdb9d4cf4e0a 471 SUPERFAMILY SSF52266 242 417 4.67E-73 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21220 311b889e797a44a2aaf9fdb9d4cf4e0a 471 SUPERFAMILY SSF52266 101 209 4.67E-73 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21220 311b889e797a44a2aaf9fdb9d4cf4e0a 471 Pfam PF03629 Carbohydrate esterase, sialic acid-specific acetylesterase 102 357 1.0E-84 T 21-04-2016 IPR005181 Sialate O-acetylesterase domain SPH21_RS21220 311b889e797a44a2aaf9fdb9d4cf4e0a 471 PANTHER PTHR22901:SF0 1 469 1.6E-140 T 21-04-2016 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SUPERFAMILY SSF50978 4 301 1.55E-59 T 21-04-2016 IPR017986 WD40-repeat-containing domain GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 PRINTS PR00320 G protein beta WD-40 repeat signature 115 129 4.3E-5 T 21-04-2016 IPR020472 G-protein beta WD-40 repeat SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 PRINTS PR00320 G protein beta WD-40 repeat signature 241 255 4.3E-5 T 21-04-2016 IPR020472 G-protein beta WD-40 repeat SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 PRINTS PR00320 G protein beta WD-40 repeat signature 288 302 4.3E-5 T 21-04-2016 IPR020472 G-protein beta WD-40 repeat SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SMART SM00320 131 170 0.89 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SMART SM00320 89 128 5.2E-4 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SMART SM00320 47 86 16.0 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SMART SM00320 215 254 0.002 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SMART SM00320 5 44 0.031 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SMART SM00320 173 212 1.5E-5 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 SMART SM00320 263 301 0.041 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 Gene3D G3DSA:2.130.10.10 8 301 4.6E-58 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 PANTHER PTHR22847 10 301 7.5E-48 T 21-04-2016 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 Pfam PF00400 WD domain, G-beta repeat 96 128 0.016 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 Pfam PF00400 WD domain, G-beta repeat 270 301 0.1 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 Pfam PF00400 WD domain, G-beta repeat 181 210 4.1E-4 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS25345 ef7654941ec445bdd25c3672dc324e29 305 Pfam PF00400 WD domain, G-beta repeat 220 253 6.8E-5 T 21-04-2016 IPR001680 WD40 repeat GO:0005515 SPH21_RS14365 375d5aa2012456c727e22abb15b1ed6c 560 Pfam PF07980 SusD family 253 557 9.7E-36 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14365 375d5aa2012456c727e22abb15b1ed6c 560 SUPERFAMILY SSF48452 15 557 2.49E-89 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14365 375d5aa2012456c727e22abb15b1ed6c 560 Gene3D G3DSA:1.25.40.10 190 298 3.9E-27 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14365 375d5aa2012456c727e22abb15b1ed6c 560 Gene3D G3DSA:1.25.40.10 391 491 3.9E-27 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14365 375d5aa2012456c727e22abb15b1ed6c 560 Pfam PF14322 Starch-binding associating with outer membrane 32 208 1.3E-20 T 21-04-2016 SPH21_RS01680 19978dc947e5b80afcd064b73dfa5ba4 158 Hamap MF_00658 Ribosomal RNA large subunit methyltransferase H [rlmH]. 1 157 26.821 T 21-04-2016 IPR003742 SPOUT methyltransferase, predicted GO:0005737|GO:0006364|GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS01680 19978dc947e5b80afcd064b73dfa5ba4 158 PANTHER PTHR33603 1 157 1.9E-52 T 21-04-2016 SPH21_RS01680 19978dc947e5b80afcd064b73dfa5ba4 158 PANTHER PTHR33603:SF1 1 157 1.9E-52 T 21-04-2016 SPH21_RS01680 19978dc947e5b80afcd064b73dfa5ba4 158 Pfam PF02590 Predicted SPOUT methyltransferase 1 156 4.2E-52 T 21-04-2016 IPR003742 SPOUT methyltransferase, predicted GO:0005737|GO:0006364|GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS01680 19978dc947e5b80afcd064b73dfa5ba4 158 PIRSF PIRSF004505 1 157 1.4E-48 T 21-04-2016 IPR003742 SPOUT methyltransferase, predicted GO:0005737|GO:0006364|GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS01680 19978dc947e5b80afcd064b73dfa5ba4 158 Gene3D G3DSA:3.40.1280.10 1 157 5.8E-54 T 21-04-2016 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SPH21_RS01680 19978dc947e5b80afcd064b73dfa5ba4 158 SUPERFAMILY SSF75217 1 156 3.18E-46 T 21-04-2016 IPR029028 Alpha/beta knot methyltransferases SPH21_RS06825 6c671e2b7a8e3006abed1c5b348ffa96 196 Pfam PF02581 Thiamine monophosphate synthase/TENI 4 165 3.0E-11 T 21-04-2016 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357|UniPathway: UPA00060 SPH21_RS06825 6c671e2b7a8e3006abed1c5b348ffa96 196 SUPERFAMILY SSF51391 6 188 1.12E-16 T 21-04-2016 IPR022998 Thiamin phosphate synthase superfamily KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357|UniPathway: UPA00060 SPH21_RS06825 6c671e2b7a8e3006abed1c5b348ffa96 196 Gene3D G3DSA:3.20.20.70 1 191 8.2E-39 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS06825 6c671e2b7a8e3006abed1c5b348ffa96 196 PANTHER PTHR20857:SF21 1 190 1.3E-17 T 21-04-2016 SPH21_RS06825 6c671e2b7a8e3006abed1c5b348ffa96 196 PANTHER PTHR20857 1 190 1.3E-17 T 21-04-2016 SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SUPERFAMILY SSF50998 589 724 1.83E-137 T 21-04-2016 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SUPERFAMILY SSF50998 415 478 1.83E-137 T 21-04-2016 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SUPERFAMILY SSF50998 34 377 1.83E-137 T 21-04-2016 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SMART SM00564 656 689 0.0019 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SMART SM00564 85 116 0.0094 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SMART SM00564 264 314 3.5 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SMART SM00564 195 234 1.3 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SMART SM00564 609 633 100.0 T 21-04-2016 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Pfam PF13360 PQQ-like domain 616 715 8.4E-8 T 21-04-2016 IPR002372 Pyrrolo-quinoline quinone repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Pfam PF13360 PQQ-like domain 86 231 1.2E-4 T 21-04-2016 IPR002372 Pyrrolo-quinoline quinone repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III 487 558 3.6E-9 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 PANTHER PTHR32303:SF4 34 363 6.4E-70 T 21-04-2016 SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 PANTHER PTHR32303:SF4 590 733 6.4E-70 T 21-04-2016 SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 SUPERFAMILY SSF46626 468 560 1.76E-15 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Gene3D G3DSA:2.140.10.10 32 390 9.1E-152 T 21-04-2016 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Gene3D G3DSA:2.140.10.10 593 733 9.1E-152 T 21-04-2016 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Gene3D G3DSA:2.140.10.10 426 482 9.1E-152 T 21-04-2016 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Gene3D G3DSA:1.10.760.10 483 578 3.7E-16 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 Pfam PF01011 PQQ enzyme repeat 296 322 3.2E-5 T 21-04-2016 IPR002372 Pyrrolo-quinoline quinone repeat SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 PANTHER PTHR32303 34 363 6.4E-70 T 21-04-2016 SPH21_RS13755 d0b1384f6ab166f7789e4a6ab0cc7845 733 PANTHER PTHR32303 590 733 6.4E-70 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Gene3D G3DSA:2.60.40.1120 35 117 1.9E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Pfam PF07715 TonB-dependent Receptor Plug Domain 124 230 2.9E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Gene3D G3DSA:2.170.130.10 118 230 6.5E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Gene3D G3DSA:2.40.170.20 916 1062 5.1E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Gene3D G3DSA:2.40.170.20 369 848 5.1E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Gene3D G3DSA:2.40.170.20 231 271 5.1E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 SUPERFAMILY SSF49464 34 113 6.93E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 SUPERFAMILY SSF56935 484 836 3.3E-85 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 SUPERFAMILY SSF56935 907 951 3.3E-85 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 SUPERFAMILY SSF56935 983 1062 3.3E-85 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 SUPERFAMILY SSF56935 111 254 3.3E-85 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 SUPERFAMILY SSF56935 360 448 3.3E-85 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Pfam PF13715 CarboxypepD_reg-like domain 35 115 1.8E-16 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 206 236 9.5E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 Pfam PF00593 TonB dependent receptor 665 1060 2.5E-16 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 PANTHER PTHR11532 1 321 2.4E-214 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 PANTHER PTHR11532 350 414 2.4E-214 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 PANTHER PTHR11532 512 1060 2.4E-214 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 PANTHER PTHR11532:SF57 1 321 2.4E-214 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 PANTHER PTHR11532:SF57 350 414 2.4E-214 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 PANTHER PTHR11532:SF57 512 1060 2.4E-214 T 21-04-2016 SPH21_RS02465 9d3feea0d0976d305179a8fc8d769cae 1062 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 35 1062 5.2E-241 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 PANTHER PTHR11532:SF57 200 295 2.5E-18 T 21-04-2016 SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 Gene3D G3DSA:3.30.1150.10 340 403 5.0E-4 T 21-04-2016 SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 TIGRFAM TIGR01352 tonB_Cterm: TonB family C-terminal domain 344 404 8.5E-7 T 21-04-2016 IPR006260 TonB, C-terminal GO:0006810 SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 Pfam PF13715 CarboxypepD_reg-like domain 200 281 5.4E-15 T 21-04-2016 SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 PANTHER PTHR11532 200 295 2.5E-18 T 21-04-2016 SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 Gene3D G3DSA:2.60.40.1120 200 288 9.2E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 SUPERFAMILY SSF49464 199 278 3.79E-11 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 Pfam PF03544 Gram-negative bacterial TonB protein C-terminal 343 403 8.1E-7 T 21-04-2016 IPR006260 TonB, C-terminal GO:0006810 SPH21_RS03185 67048428126c094d3a8d423f8e85790e 406 SUPERFAMILY SSF74653 337 403 1.02E-6 T 21-04-2016 SPH21_RS16245 ccc2349bbf2386d380691b4830fe3111 568 Pfam PF07980 SusD family 270 568 3.3E-37 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS16245 ccc2349bbf2386d380691b4830fe3111 568 SUPERFAMILY SSF48452 16 499 1.52E-90 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16245 ccc2349bbf2386d380691b4830fe3111 568 SUPERFAMILY SSF48452 532 568 1.52E-90 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16245 ccc2349bbf2386d380691b4830fe3111 568 Gene3D G3DSA:1.25.40.10 200 304 1.8E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16245 ccc2349bbf2386d380691b4830fe3111 568 Gene3D G3DSA:1.25.40.10 359 472 1.8E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16245 ccc2349bbf2386d380691b4830fe3111 568 Pfam PF14322 Starch-binding associating with outer membrane 101 214 8.6E-9 T 21-04-2016 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 PANTHER PTHR10937:SF0 1 611 0.0 T 21-04-2016 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: REACT_17015 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 Gene3D G3DSA:3.60.20.10 2 231 2.9E-77 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 Gene3D G3DSA:3.40.50.10490 445 611 3.3E-65 T 21-04-2016 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 SUPERFAMILY SSF53697 246 611 7.42E-119 T 21-04-2016 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 Gene3D G3DSA:3.40.50.10490 245 444 7.7E-81 T 21-04-2016 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 Pfam PF13522 Glutamine amidotransferase domain 63 193 3.9E-21 T 21-04-2016 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 PANTHER PTHR10937 1 611 0.0 T 21-04-2016 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 Hamap MF_00164 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] [glmS]. 1 611 39.781 T 21-04-2016 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: REACT_17015 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 Pfam PF01380 SIS domain 464 593 2.6E-28 T 21-04-2016 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 Reactome: REACT_17015 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 Pfam PF01380 SIS domain 292 419 2.9E-32 T 21-04-2016 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 Reactome: REACT_17015 SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 SUPERFAMILY SSF56235 2 232 3.0E-70 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS10175 a069a405c1da34ba7e1e126aba26947a 611 TIGRFAM TIGR01135 glmS: glutamine-fructose-6-phosphate transaminase (isomerizing) 2 611 1.2E-247 T 21-04-2016 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: REACT_17015 SPH21_RS06080 93c96da5d0b34c9c956359d432a5dcd7 125 PANTHER PTHR34134 5 125 7.5E-31 T 21-04-2016 SPH21_RS06080 93c96da5d0b34c9c956359d432a5dcd7 125 PANTHER PTHR34134:SF1 5 125 7.5E-31 T 21-04-2016 SPH21_RS06080 93c96da5d0b34c9c956359d432a5dcd7 125 Gene3D G3DSA:1.10.10.10 1 79 7.7E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06080 93c96da5d0b34c9c956359d432a5dcd7 125 Pfam PF03965 Penicillinase repressor 7 119 3.6E-28 T 21-04-2016 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SPH21_RS06080 93c96da5d0b34c9c956359d432a5dcd7 125 SUPERFAMILY SSF46785 4 122 9.63E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06080 93c96da5d0b34c9c956359d432a5dcd7 125 PIRSF PIRSF019455 1 125 1.5E-24 T 21-04-2016 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 Gene3D G3DSA:3.90.10.10 238 293 4.4E-9 T 21-04-2016 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 SUPERFAMILY SSF48695 232 385 7.37E-33 T 21-04-2016 IPR011031 Multihaem cytochrome SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 Pfam PF00034 Cytochrome c 34 120 2.0E-9 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 Pfam PF14522 Cytochrome c7 and related cytochrome c 336 423 1.3E-8 T 21-04-2016 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 SUPERFAMILY SSF46626 15 123 7.68E-20 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 PANTHER PTHR39425:SF1 198 383 8.4E-40 T 21-04-2016 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 PANTHER PTHR39425 198 383 8.4E-40 T 21-04-2016 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 Gene3D G3DSA:1.10.760.10 22 125 3.3E-19 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS07660 c710eb9784d879a606f176f3f665f8ab 423 Gene3D G3DSA:3.90.10.10 326 422 9.7E-13 T 21-04-2016 SPH21_RS06035 34417ae784c684c871d8864585fb04fc 791 Pfam PF02687 FtsX-like permease family 290 406 1.6E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06035 34417ae784c684c871d8864585fb04fc 791 Pfam PF02687 FtsX-like permease family 672 784 4.6E-13 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06035 34417ae784c684c871d8864585fb04fc 791 Pfam PF12704 MacB-like periplasmic core domain 20 244 3.2E-19 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS06035 34417ae784c684c871d8864585fb04fc 791 PANTHER PTHR30572 403 791 7.8E-66 T 21-04-2016 SPH21_RS06035 34417ae784c684c871d8864585fb04fc 791 PANTHER PTHR30572 283 356 7.8E-66 T 21-04-2016 SPH21_RS06035 34417ae784c684c871d8864585fb04fc 791 PANTHER PTHR30572:SF4 403 791 7.8E-66 T 21-04-2016 SPH21_RS06035 34417ae784c684c871d8864585fb04fc 791 PANTHER PTHR30572:SF4 283 356 7.8E-66 T 21-04-2016 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 TIGRFAM TIGR00070 hisG: ATP phosphoribosyltransferase 4 184 6.7E-58 T 21-04-2016 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17|UniPathway: UPA00031 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 TIGRFAM TIGR03455 HisG_C-term: ATP phosphoribosyltransferase, C-terminal domain 190 282 1.3E-31 T 21-04-2016 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17|UniPathway: UPA00031 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 PANTHER PTHR21403 4 283 3.6E-107 T 21-04-2016 IPR001348 ATP phosphoribosyltransferase HisG GO:0000105|GO:0003879 KEGG: 00340+2.4.2.17|UniPathway: UPA00031 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 Pfam PF01634 ATP phosphoribosyltransferase 51 203 1.5E-49 T 21-04-2016 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17|UniPathway: UPA00031 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 SUPERFAMILY SSF53850 4 208 7.51E-61 T 21-04-2016 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 Gene3D G3DSA:3.40.190.10 2 127 1.8E-43 T 21-04-2016 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 Hamap MF_00079 ATP phosphoribosyltransferase [hisG]. 3 283 33.665 T 21-04-2016 IPR020621 ATP phosphoribosyltransferase HisG, long form GO:0000105|GO:0003879 KEGG: 00340+2.4.2.17|UniPathway: UPA00031 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 PANTHER PTHR21403:SF0 4 283 3.6E-107 T 21-04-2016 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 ProSitePatterns PS01316 ATP phosphoribosyltransferase signature. 144 165 - T 21-04-2016 IPR018198 ATP phosphoribosyltransferase, conserved site GO:0003879 KEGG: 00340+2.4.2.17|UniPathway: UPA00031 SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 SUPERFAMILY SSF54913 211 282 3.78E-21 T 21-04-2016 IPR011322 Nitrogen regulatory PII-like, alpha/beta SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 Gene3D G3DSA:3.30.70.120 212 282 5.5E-28 T 21-04-2016 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal SPH21_RS25305 0acf7aa381fc09ff0b63575fa6de0961 283 Pfam PF08029 HisG, C-terminal domain 208 280 1.5E-26 T 21-04-2016 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17|UniPathway: UPA00031 SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 Gene3D G3DSA:3.30.70.100 174 259 8.7E-24 T 21-04-2016 SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 SUPERFAMILY SSF82861 20 104 3.92E-18 T 21-04-2016 IPR011014 Mechanosensitive ion channel MscS, transmembrane-2 GO:0016020 SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 SUPERFAMILY SSF50182 106 172 1.8E-13 T 21-04-2016 IPR010920 LSM domain SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 PANTHER PTHR30221 2 275 2.5E-75 T 21-04-2016 SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 SUPERFAMILY SSF82689 174 271 9.68E-31 T 21-04-2016 IPR011066 Mechanosensitive ion channel MscS, C-terminal GO:0016020 SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 Gene3D G3DSA:2.30.30.60 121 170 1.6E-11 T 21-04-2016 SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 Pfam PF00924 Mechanosensitive ion channel 63 261 5.1E-48 T 21-04-2016 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SPH21_RS19990 20a4fb3bd9200850be9363c510343b5a 279 PANTHER PTHR30221:SF7 2 275 2.5E-75 T 21-04-2016 SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 88 304 1.2E-31 T 21-04-2016 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 SUPERFAMILY SSF51445 37 338 7.5E-52 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 PANTHER PTHR34142 115 212 1.7E-13 T 21-04-2016 SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 Gene3D G3DSA:3.20.20.80 31 332 3.6E-66 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 Pfam PF03422 Carbohydrate binding module (family 6) 392 502 1.4E-16 T 21-04-2016 IPR005084 Carbohydrate binding module family 6 GO:0030246 SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 PANTHER PTHR34142:SF1 115 212 1.7E-13 T 21-04-2016 SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 Gene3D G3DSA:2.60.120.260 356 502 6.6E-30 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 SUPERFAMILY SSF49785 355 502 7.76E-25 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 ProSitePatterns PS00659 Glycosyl hydrolases family 5 signature. 166 175 - T 21-04-2016 IPR018087 Glycoside hydrolase, family 5, conserved site GO:0004553|GO:0005975 SPH21_RS22225 4d73cdd2a08a6b604331b934edc10f56 506 SMART SM00606 376 504 7.1E-14 T 21-04-2016 IPR006584 Cellulose binding, type IV GO:0030246 SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 PRINTS PR00127 Clp protease catalytic subunit P signature 82 99 5.6E-10 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 PRINTS PR00127 Clp protease catalytic subunit P signature 51 71 5.6E-10 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 PRINTS PR00127 Clp protease catalytic subunit P signature 162 181 5.6E-10 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 Pfam PF00574 Clp protease 42 184 8.6E-28 T 21-04-2016 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 PANTHER PTHR10381:SF22 52 247 5.5E-20 T 21-04-2016 SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 SUPERFAMILY SSF52096 11 185 1.42E-35 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 Gene3D G3DSA:3.90.226.10 7 188 7.1E-35 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS17335 531fe6d0a2203ffdfe5164a8312ab018 373 PANTHER PTHR10381 52 247 5.5E-20 T 21-04-2016 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SPH21_RS26045 eabc5c57d3da773e3be899fac97cae30 367 PANTHER PTHR34220 25 363 5.4E-49 T 21-04-2016 SPH21_RS26045 eabc5c57d3da773e3be899fac97cae30 367 Pfam PF06580 Histidine kinase 176 252 2.0E-24 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS26045 eabc5c57d3da773e3be899fac97cae30 367 PANTHER PTHR34220:SF1 25 363 5.4E-49 T 21-04-2016 SPH21_RS26045 eabc5c57d3da773e3be899fac97cae30 367 SUPERFAMILY SSF55874 238 339 1.67E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 PANTHER PTHR12147:SF16 36 177 6.6E-52 T 21-04-2016 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 PANTHER PTHR12147:SF16 260 519 6.6E-52 T 21-04-2016 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 Pfam PF04389 Peptidase family M28 296 506 1.1E-42 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 SUPERFAMILY SSF53187 280 513 2.23E-64 T 21-04-2016 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 SUPERFAMILY SSF53187 29 78 2.23E-64 T 21-04-2016 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 Gene3D G3DSA:3.40.630.10 22 84 2.9E-68 T 21-04-2016 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 Gene3D G3DSA:3.40.630.10 281 519 2.9E-68 T 21-04-2016 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 PANTHER PTHR12147 36 177 6.6E-52 T 21-04-2016 SPH21_RS00080 15a3d27483711903aea24e45da737b46 526 PANTHER PTHR12147 260 519 6.6E-52 T 21-04-2016 SPH21_RS13320 bef0f2e0884df4d77840606252677514 206 PANTHER PTHR19136:SF81 10 193 1.3E-27 T 21-04-2016 SPH21_RS13320 bef0f2e0884df4d77840606252677514 206 Hamap MF_00316 Molybdenum cofactor guanylyltransferase [mobA]. 9 192 21.517 T 21-04-2016 IPR013482 Molybdenum cofactor guanylyltransferase GO:0003824|GO:0006777 MetaCyc: PWY-5964|MetaCyc: PWY-7639 SPH21_RS13320 bef0f2e0884df4d77840606252677514 206 Pfam PF12804 MobA-like NTP transferase domain 13 147 3.5E-26 T 21-04-2016 IPR025877 MobA-like NTP transferase SPH21_RS13320 bef0f2e0884df4d77840606252677514 206 SUPERFAMILY SSF53448 11 148 1.8E-24 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS13320 bef0f2e0884df4d77840606252677514 206 PANTHER PTHR19136 10 193 1.3E-27 T 21-04-2016 SPH21_RS13320 bef0f2e0884df4d77840606252677514 206 Gene3D G3DSA:3.90.550.10 10 197 1.3E-36 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Pfam PF10410 DnaB-helicase binding domain of primase 381 421 3.1E-5 T 21-04-2016 IPR019475 DNA primase, DnaB-helicase binding domain GO:0016779 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Gene3D G3DSA:3.90.980.10 113 241 1.8E-40 T 21-04-2016 IPR013264 DNA primase, catalytic core, N-terminal SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 SMART SM00400 33 87 1.5E-31 T 21-04-2016 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 SMART SM00493 260 331 2.2E-15 T 21-04-2016 IPR006171 Toprim domain SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 PANTHER PTHR30313 1 643 1.9E-133 T 21-04-2016 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Gene3D G3DSA:3.40.1360.10 242 363 7.3E-43 T 21-04-2016 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 TIGRFAM TIGR01391 dnaG: DNA primase 1 415 1.5E-134 T 21-04-2016 IPR006295 DNA primase, DnaG GO:0003896|GO:0006269 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 SUPERFAMILY SSF56731 113 421 6.8E-94 T 21-04-2016 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Gene3D G3DSA:3.90.580.10 1 98 1.0E-36 T 21-04-2016 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Pfam PF01807 CHC2 zinc finger 3 96 4.6E-34 T 21-04-2016 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Pfam PF08275 DNA primase catalytic core, N-terminal domain 124 252 6.7E-38 T 21-04-2016 IPR013264 DNA primase, catalytic core, N-terminal SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Hamap MF_00974 DNA primase [dnaG]. 1 639 26.862 T 21-04-2016 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 Pfam PF13662 Toprim domain 263 336 6.9E-17 T 21-04-2016 IPR006171 Toprim domain SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 SUPERFAMILY SSF57783 1 98 4.08E-33 T 21-04-2016 SPH21_RS03325 6baeccc4f736439c917f0237fc71c28f 658 PIRSF PIRSF002811 1 645 1.9E-149 T 21-04-2016 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 SPH21_RS05525 987c617f5dc35ff0d9c106d7f74dcebc 380 PANTHER PTHR30158 1 371 1.1E-95 T 21-04-2016 SPH21_RS05525 987c617f5dc35ff0d9c106d7f74dcebc 380 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 59 280 2.6E-17 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS05525 987c617f5dc35ff0d9c106d7f74dcebc 380 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 48 362 1.5E-80 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS05525 987c617f5dc35ff0d9c106d7f74dcebc 380 Gene3D G3DSA:2.40.50.100 60 93 3.9E-16 T 21-04-2016 SPH21_RS05525 987c617f5dc35ff0d9c106d7f74dcebc 380 Gene3D G3DSA:2.40.50.100 168 199 3.9E-16 T 21-04-2016 SPH21_RS05525 987c617f5dc35ff0d9c106d7f74dcebc 380 SUPERFAMILY SSF111369 48 287 5.62E-52 T 21-04-2016 SPH21_RS21895 faa9c818f05a886cdf092b5d64b1ca68 202 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 177 1.0E-6 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21895 faa9c818f05a886cdf092b5d64b1ca68 202 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 69 80 1.0E-6 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21895 faa9c818f05a886cdf092b5d64b1ca68 202 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 1.0E-6 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21895 faa9c818f05a886cdf092b5d64b1ca68 202 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 140 159 1.0E-6 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21895 faa9c818f05a886cdf092b5d64b1ca68 202 Gene3D G3DSA:3.40.50.720 15 173 2.7E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21895 faa9c818f05a886cdf092b5d64b1ca68 202 SUPERFAMILY SSF51735 12 172 3.44E-21 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21895 faa9c818f05a886cdf092b5d64b1ca68 202 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 40 175 5.4E-11 T 21-04-2016 SPH21_RS11785 4e9f1e6fa908234f17cfd523942c4038 346 PANTHER PTHR34220:SF3 152 344 1.2E-52 T 21-04-2016 SPH21_RS11785 4e9f1e6fa908234f17cfd523942c4038 346 Gene3D G3DSA:3.30.565.10 209 339 1.5E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS11785 4e9f1e6fa908234f17cfd523942c4038 346 Pfam PF06580 Histidine kinase 158 237 5.5E-26 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS11785 4e9f1e6fa908234f17cfd523942c4038 346 PANTHER PTHR34220 152 344 1.2E-52 T 21-04-2016 SPH21_RS11785 4e9f1e6fa908234f17cfd523942c4038 346 SUPERFAMILY SSF55874 213 327 1.4E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 Gene3D G3DSA:3.30.930.10 20 343 1.3E-118 T 21-04-2016 SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 Hamap MF_00281 Phenylalanine--tRNA ligase alpha subunit [pheS]. 4 342 42.241 T 21-04-2016 IPR022911 Phenylalanine-tRNA ligase alpha chain 1, bacterial GO:0004826 KEGG: 00970+6.1.1.20 SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 Pfam PF01409 tRNA synthetases class II core domain (F) 93 342 1.3E-97 T 21-04-2016 IPR002319 Phenylalanyl-tRNA synthetase GO:0000049|GO:0004812|GO:0005524|GO:0005737|GO:0043039 KEGG: 00970+6.1.1.20 SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 SUPERFAMILY SSF46589 20 98 2.51E-10 T 21-04-2016 IPR010978 tRNA-binding arm GO:0000166 Reactome: REACT_71 SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 PANTHER PTHR11538 93 342 9.7E-104 T 21-04-2016 SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 SUPERFAMILY SSF55681 93 343 4.75E-78 T 21-04-2016 SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 TIGRFAM TIGR00468 pheS: phenylalanine--tRNA ligase, alpha subunit 40 343 1.9E-93 T 21-04-2016 IPR004529 Phenylalanyl-tRNA synthetase, class IIc, alpha subunit GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 SPH21_RS07200 e16512475d145c9e83140f2c5aedef4c 347 Pfam PF02912 Aminoacyl tRNA synthetase class II, N-terminal domain 21 84 6.2E-12 T 21-04-2016 IPR004188 Phenylalanine-tRNA ligase, class II, N-terminal GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 SPH21_RS05160 dfd29bd00e6bf30aa4059de7602e9be4 346 Gene3D G3DSA:3.90.25.10 186 343 3.9E-53 T 21-04-2016 SPH21_RS05160 dfd29bd00e6bf30aa4059de7602e9be4 346 Gene3D G3DSA:3.40.50.720 1 185 2.5E-70 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05160 dfd29bd00e6bf30aa4059de7602e9be4 346 PANTHER PTHR10366 2 345 1.3E-165 T 21-04-2016 SPH21_RS05160 dfd29bd00e6bf30aa4059de7602e9be4 346 SUPERFAMILY SSF51735 1 344 1.67E-96 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05160 dfd29bd00e6bf30aa4059de7602e9be4 346 Pfam PF16363 GDP-mannose 4,6 dehydratase 4 318 1.3E-99 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05160 dfd29bd00e6bf30aa4059de7602e9be4 346 PANTHER PTHR10366:SF41 2 345 1.3E-165 T 21-04-2016 IPR005888 dTDP-glucose 4,6-dehydratase GO:0008460|GO:0009225 KEGG: 00521+4.2.1.46|KEGG: 00523+4.2.1.46|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 SPH21_RS05160 dfd29bd00e6bf30aa4059de7602e9be4 346 TIGRFAM TIGR01181 dTDP_gluc_dehyt: dTDP-glucose 4,6-dehydratase 3 331 3.3E-142 T 21-04-2016 IPR005888 dTDP-glucose 4,6-dehydratase GO:0008460|GO:0009225 KEGG: 00521+4.2.1.46|KEGG: 00523+4.2.1.46|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 Pfam PF01037 Lrp/AsnC ligand binding domain 71 145 1.9E-23 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 SUPERFAMILY SSF54909 68 153 3.75E-22 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 PANTHER PTHR30154:SF28 1 155 8.3E-56 T 21-04-2016 SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 32 51 4.0E-15 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 5 21 4.0E-15 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 21 32 4.0E-15 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 SMART SM00344 6 114 4.8E-36 T 21-04-2016 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 Gene3D G3DSA:3.30.70.920 58 154 1.0E-29 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 SUPERFAMILY SSF46785 6 64 3.53E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 ProSitePatterns PS00519 AsnC-type HTH domain signature. 23 49 - T 21-04-2016 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 Gene3D G3DSA:1.10.10.10 6 57 4.1E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 PANTHER PTHR30154 1 155 8.3E-56 T 21-04-2016 SPH21_RS19910 2d2b595991b6fdf08e8d0be2c38f3420 156 Pfam PF13412 Winged helix-turn-helix DNA-binding 6 52 1.0E-17 T 21-04-2016 SPH21_RS11580 544e3772eae9e2a0a84e14c12aaa5eb0 679 PANTHER PTHR31151:SF4 349 677 6.8E-239 T 21-04-2016 SPH21_RS11580 544e3772eae9e2a0a84e14c12aaa5eb0 679 PANTHER PTHR31151:SF4 1 331 6.8E-239 T 21-04-2016 SPH21_RS11580 544e3772eae9e2a0a84e14c12aaa5eb0 679 PANTHER PTHR31151 349 677 6.8E-239 T 21-04-2016 SPH21_RS11580 544e3772eae9e2a0a84e14c12aaa5eb0 679 PANTHER PTHR31151 1 331 6.8E-239 T 21-04-2016 SPH21_RS11580 544e3772eae9e2a0a84e14c12aaa5eb0 679 Gene3D G3DSA:1.50.10.10 167 315 8.8E-9 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS11580 544e3772eae9e2a0a84e14c12aaa5eb0 679 SUPERFAMILY SSF48208 52 432 1.17E-28 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS11580 544e3772eae9e2a0a84e14c12aaa5eb0 679 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 46 586 1.4E-171 T 21-04-2016 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 Gene3D G3DSA:3.90.700.10 267 403 2.9E-17 T 21-04-2016 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 Pfam PF00890 FAD binding domain 36 448 1.3E-51 T 21-04-2016 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 PANTHER PTHR11632 1 645 0.0 T 21-04-2016 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 SUPERFAMILY SSF51905 413 460 5.81E-49 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 SUPERFAMILY SSF51905 30 277 5.81E-49 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 Gene3D G3DSA:3.50.50.60 26 266 2.8E-75 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 Gene3D G3DSA:3.50.50.60 405 457 2.8E-75 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 PANTHER PTHR11632:SF53 1 645 0.0 T 21-04-2016 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 SUPERFAMILY SSF46977 501 644 3.53E-38 T 21-04-2016 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 36 55 4.1E-8 T 21-04-2016 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 412 434 4.1E-8 T 21-04-2016 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 TIGRFAM TIGR01811 sdhA_Bsu: succinate dehydrogenase or fumarate reductase, flavoprotein subunit 36 644 8.3E-294 T 21-04-2016 IPR011280 Succinate dehydrogenase/fumarate reductase flavoprotein subunit, low-GC Gram-positive bacteria KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|UniPathway: UPA00223 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 Pfam PF02910 Fumarate reductase flavoprotein C-term 510 644 1.5E-35 T 21-04-2016 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 SUPERFAMILY SSF56425 261 410 1.09E-30 T 21-04-2016 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain SPH21_RS06910 31fa784d499a0108a56147bb787654a5 645 Gene3D G3DSA:1.20.58.100 481 595 8.4E-31 T 21-04-2016 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Gene3D G3DSA:2.60.40.1120 128 218 4.0E-18 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 PANTHER PTHR11532:SF57 689 1169 2.4E-224 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 PANTHER PTHR11532:SF57 124 519 2.4E-224 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 PANTHER PTHR11532:SF57 634 663 2.4E-224 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Gene3D G3DSA:2.170.130.10 219 328 1.3E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 303 333 8.0E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 SUPERFAMILY SSF56935 433 523 5.95E-72 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 SUPERFAMILY SSF56935 1072 1122 5.95E-72 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 SUPERFAMILY SSF56935 211 351 5.95E-72 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 SUPERFAMILY SSF56935 987 1031 5.95E-72 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 SUPERFAMILY SSF56935 553 906 5.95E-72 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 128 1171 3.0E-233 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Pfam PF07715 TonB-dependent Receptor Plug Domain 222 327 1.1E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 SUPERFAMILY SSF49464 128 223 7.45E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 PANTHER PTHR11532 689 1169 2.4E-224 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 PANTHER PTHR11532 124 519 2.4E-224 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 PANTHER PTHR11532 634 663 2.4E-224 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Pfam PF13715 CarboxypepD_reg-like domain 128 214 8.8E-17 T 21-04-2016 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Gene3D G3DSA:2.40.170.20 1072 1167 3.6E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Gene3D G3DSA:2.40.170.20 329 349 3.6E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Gene3D G3DSA:2.40.170.20 996 1031 3.6E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03945 22b7b00c9c532f09d0caf9d62737e6d8 1171 Gene3D G3DSA:2.40.170.20 442 927 3.6E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 Pfam PF06463 Molybdenum Cofactor Synthesis C 182 301 1.8E-32 T 21-04-2016 IPR010505 Molybdenum cofactor synthesis C-terminal GO:0006777|GO:0019008|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 TIGRFAM TIGR02666 moaA: molybdenum cofactor biosynthesis protein A 5 329 1.6E-101 T 21-04-2016 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 SUPERFAMILY SSF102114 6 273 1.44E-67 T 21-04-2016 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 Pfam PF04055 Radical SAM superfamily 19 174 7.1E-31 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 SMART SM00729 14 214 6.7E-7 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 Pfam PF13353 4Fe-4S single cluster domain 21 122 1.6E-9 T 21-04-2016 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 ProSitePatterns PS01305 moaA / nifB / pqqE family signature. 20 31 - T 21-04-2016 IPR000385 MoaA/nifB/pqqE, iron-sulphur binding, conserved site GO:0003824|GO:0046872|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 Gene3D G3DSA:3.20.20.70 5 281 2.3E-72 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS00680 a5290928b7d7379da0133b0473728172 329 PANTHER PTHR22960 5 279 4.1E-112 T 21-04-2016 SPH21_RS26000 0d07f2ef7192086e37178eee2ce4cb3f 492 PANTHER PTHR10681 78 305 3.2E-19 T 21-04-2016 SPH21_RS26000 0d07f2ef7192086e37178eee2ce4cb3f 492 Gene3D G3DSA:3.40.30.10 43 203 4.0E-30 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26000 0d07f2ef7192086e37178eee2ce4cb3f 492 SUPERFAMILY SSF52833 75 239 1.37E-25 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26000 0d07f2ef7192086e37178eee2ce4cb3f 492 PANTHER PTHR10681:SF68 78 305 3.2E-19 T 21-04-2016 SPH21_RS26000 0d07f2ef7192086e37178eee2ce4cb3f 492 Pfam PF00578 AhpC/TSA family 80 175 1.7E-12 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS11525 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF02371 Transposase IS116/IS110/IS902 family 208 291 3.3E-22 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS11525 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055 4 339 1.1E-48 T 21-04-2016 SPH21_RS11525 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055:SF3 4 339 1.1E-48 T 21-04-2016 SPH21_RS11525 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF01548 Transposase 8 164 8.9E-28 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS03170 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF02371 Transposase IS116/IS110/IS902 family 208 291 3.3E-22 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS03170 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055 4 339 1.1E-48 T 21-04-2016 SPH21_RS03170 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055:SF3 4 339 1.1E-48 T 21-04-2016 SPH21_RS03170 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF01548 Transposase 8 164 8.9E-28 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS02035 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF02371 Transposase IS116/IS110/IS902 family 208 291 3.3E-22 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS02035 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055 4 339 1.1E-48 T 21-04-2016 SPH21_RS02035 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055:SF3 4 339 1.1E-48 T 21-04-2016 SPH21_RS02035 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF01548 Transposase 8 164 8.9E-28 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS07245 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF02371 Transposase IS116/IS110/IS902 family 208 291 3.3E-22 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS07245 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055 4 339 1.1E-48 T 21-04-2016 SPH21_RS07245 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055:SF3 4 339 1.1E-48 T 21-04-2016 SPH21_RS07245 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF01548 Transposase 8 164 8.9E-28 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS08170 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF02371 Transposase IS116/IS110/IS902 family 208 291 3.3E-22 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS08170 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055 4 339 1.1E-48 T 21-04-2016 SPH21_RS08170 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055:SF3 4 339 1.1E-48 T 21-04-2016 SPH21_RS08170 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF01548 Transposase 8 164 8.9E-28 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS14405 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF02371 Transposase IS116/IS110/IS902 family 208 291 3.3E-22 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS14405 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055 4 339 1.1E-48 T 21-04-2016 SPH21_RS14405 dc5d5b740e18f592ebb229227c89cd4c 350 PANTHER PTHR33055:SF3 4 339 1.1E-48 T 21-04-2016 SPH21_RS14405 dc5d5b740e18f592ebb229227c89cd4c 350 Pfam PF01548 Transposase 8 164 8.9E-28 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS06020 a17a36344b35e7d2595ae50e8c6f060a 314 PANTHER PTHR11695 15 314 3.6E-72 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS06020 a17a36344b35e7d2595ae50e8c6f060a 314 Pfam PF13602 Zinc-binding dehydrogenase 186 308 1.4E-15 T 21-04-2016 SPH21_RS06020 a17a36344b35e7d2595ae50e8c6f060a 314 SUPERFAMILY SSF50129 1 142 8.95E-30 T 21-04-2016 IPR011032 GroES-like SPH21_RS06020 a17a36344b35e7d2595ae50e8c6f060a 314 SUPERFAMILY SSF51735 115 278 7.4E-28 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06020 a17a36344b35e7d2595ae50e8c6f060a 314 Gene3D G3DSA:3.90.180.10 1 197 6.2E-47 T 21-04-2016 IPR011032 GroES-like SPH21_RS06020 a17a36344b35e7d2595ae50e8c6f060a 314 SMART SM00829 10 310 2.1E-11 T 21-04-2016 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SPH21_RS06020 a17a36344b35e7d2595ae50e8c6f060a 314 PANTHER PTHR11695:SF294 15 314 3.6E-72 T 21-04-2016 SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 136 164 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 SUPERFAMILY SSF51735 2 193 1.59E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 PANTHER PTHR24322 149 182 3.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 PANTHER PTHR24322 8 133 3.5E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 170 187 2.4E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 2.4E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 2.4E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 2.4E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 168 2.4E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 Pfam PF00106 short chain dehydrogenase 4 190 1.3E-35 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21595 8b63643fd25f0eba0c12dec8e2669655 269 Gene3D G3DSA:3.40.50.720 4 242 1.4E-45 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 SUPERFAMILY SSF51905 506 567 5.61E-54 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 SUPERFAMILY SSF51905 104 204 5.61E-54 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 SUPERFAMILY SSF51905 230 347 5.61E-54 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 SUPERFAMILY SSF51905 11 73 5.61E-54 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 Pfam PF05199 GMC oxidoreductase 435 558 9.3E-19 T 21-04-2016 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 Pfam PF00732 GMC oxidoreductase 230 322 1.3E-5 T 21-04-2016 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 PANTHER PTHR11552 100 570 8.6E-44 T 21-04-2016 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 PANTHER PTHR11552 15 76 8.6E-44 T 21-04-2016 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 SUPERFAMILY SSF54373 368 506 5.89E-34 T 21-04-2016 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 Gene3D G3DSA:3.50.50.60 11 164 3.1E-63 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 Gene3D G3DSA:3.50.50.60 445 458 3.1E-63 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 Gene3D G3DSA:3.50.50.60 497 564 3.1E-63 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 Gene3D G3DSA:3.50.50.60 238 346 3.1E-63 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 PANTHER PTHR11552:SF139 100 570 8.6E-44 T 21-04-2016 SPH21_RS15100 89453a4794e24b3c4f354431d58ea539 571 PANTHER PTHR11552:SF139 15 76 8.6E-44 T 21-04-2016 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 Gene3D G3DSA:3.40.50.620 3 207 1.8E-80 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 Gene3D G3DSA:1.10.240.10 208 302 6.1E-19 T 21-04-2016 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 PANTHER PTHR10055:SF10 1 331 1.9E-120 T 21-04-2016 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 Hamap MF_00140_B Tryptophan--tRNA ligase [trpS]. 1 329 35.45 T 21-04-2016 IPR024109 Tryptophan-tRNA ligase, bacterial-type GO:0004830 KEGG: 00970+6.1.1.2 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 PANTHER PTHR10055 1 331 1.9E-120 T 21-04-2016 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2|Reactome: REACT_71 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 SUPERFAMILY SSF52374 3 328 7.79E-77 T 21-04-2016 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 Pfam PF00579 tRNA synthetases class I (W and Y) 3 279 1.3E-65 T 21-04-2016 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 TIGRFAM TIGR00233 trpS: tryptophan--tRNA ligase 2 328 3.6E-92 T 21-04-2016 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2|Reactome: REACT_71 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 140 161 6.1E-25 T 21-04-2016 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2|Reactome: REACT_71 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 14 30 6.1E-25 T 21-04-2016 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2|Reactome: REACT_71 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 64 83 6.1E-25 T 21-04-2016 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2|Reactome: REACT_71 SPH21_RS17475 c838b3296185c69f9325ba861e9a6345 331 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 194 204 6.1E-25 T 21-04-2016 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2|Reactome: REACT_71 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 517 523 - T 21-04-2016 IPR018303 P-type ATPase, phosphorylation site SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PANTHER PTHR24093:SF317 188 799 2.9E-205 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 SUPERFAMILY SSF56784 514 533 5.06E-53 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 SUPERFAMILY SSF56784 574 820 5.06E-53 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PANTHER PTHR24093 188 799 2.9E-205 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 SUPERFAMILY SSF81665 416 509 2.09E-16 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 SUPERFAMILY SSF81665 251 303 2.09E-16 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 SUPERFAMILY SSF81665 769 803 2.09E-16 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 249 822 1.2E-176 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 Gene3D G3DSA:3.40.1110.10 529 645 2.3E-19 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 Gene3D G3DSA:2.70.150.10 251 416 4.4E-26 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 Pfam PF00122 E1-E2 ATPase 270 506 6.2E-61 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 272 799 4.1E-77 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 515 529 8.3E-25 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 719 738 8.3E-25 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 743 755 8.3E-25 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 643 654 8.3E-25 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 349 363 8.3E-25 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 666 676 8.3E-25 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 Pfam PF00702 haloacid dehalogenase-like hydrolase 512 731 4.0E-39 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 SUPERFAMILY SSF81653 302 415 5.1E-22 T 21-04-2016 SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 Gene3D G3DSA:3.40.50.1000 488 528 1.1E-43 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01110 5695f2c013d95109a1552f734218ca3e 828 Gene3D G3DSA:3.40.50.1000 646 785 1.1E-43 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 Gene3D G3DSA:3.30.160.70 108 194 5.6E-27 T 21-04-2016 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 SMART SM00342 26 109 7.7E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 ProSitePatterns PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 246 252 - T 21-04-2016 IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site GO:0003908|GO:0006281 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 Gene3D G3DSA:1.10.10.60 66 107 5.7E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 Pfam PF12833 Helix-turn-helix domain 32 110 2.2E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 SUPERFAMILY SSF46767 195 277 1.16E-26 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 PANTHER PTHR10815 85 280 6.4E-57 T 21-04-2016 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 197 276 2.2E-26 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 196 272 1.3E-27 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 SUPERFAMILY SSF53155 115 194 1.2E-16 T 21-04-2016 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 PANTHER PTHR10815:SF5 85 280 6.4E-57 T 21-04-2016 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 Gene3D G3DSA:1.10.10.60 10 65 1.5E-17 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 Gene3D G3DSA:1.10.10.10 195 279 5.3E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13845 91e0ac15aac30c9e0861296ac53b0f4f 285 SUPERFAMILY SSF46689 9 60 5.82E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20495 64d0048e8743c68df6b447810ef624f3 366 PANTHER PTHR22893 6 355 1.3E-156 T 21-04-2016 SPH21_RS20495 64d0048e8743c68df6b447810ef624f3 366 PANTHER PTHR22893:SF9 6 355 1.3E-156 T 21-04-2016 SPH21_RS20495 64d0048e8743c68df6b447810ef624f3 366 Gene3D G3DSA:3.20.20.70 1 353 4.1E-98 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS20495 64d0048e8743c68df6b447810ef624f3 366 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 5 352 8.1E-66 T 21-04-2016 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SPH21_RS20495 64d0048e8743c68df6b447810ef624f3 366 SUPERFAMILY SSF51395 1 353 4.51E-93 T 21-04-2016 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 Pfam PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 22 422 8.9E-136 T 21-04-2016 IPR023302 Peptidase S9A, N-terminal domain GO:0004252|GO:0070008 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 Pfam PF00326 Prolyl oligopeptidase family 479 694 1.5E-70 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 SUPERFAMILY SSF50993 17 429 2.46E-99 T 21-04-2016 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PANTHER PTHR11757 20 699 0.0 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 ProSitePatterns PS00708 Prolyl endopeptidase family serine active site. 525 555 - T 21-04-2016 IPR002471 Peptidase S9, serine active site GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 490 514 2.2E-60 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 623 645 2.2E-60 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 464 482 2.2E-60 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 518 537 2.2E-60 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 604 619 2.2E-60 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 548 568 2.2E-60 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 PANTHER PTHR11757:SF2 20 699 0.0 T 21-04-2016 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 SUPERFAMILY SSF53474 432 683 1.04E-48 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 Gene3D G3DSA:2.130.10.120 88 426 5.2E-104 T 21-04-2016 IPR023302 Peptidase S9A, N-terminal domain GO:0004252|GO:0070008 SPH21_RS07165 013a4f9b381592a5ef36345540e882b3 699 Gene3D G3DSA:3.40.50.1820 431 689 2.4E-46 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 SMART SM00347 25 125 4.2E-14 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 SUPERFAMILY SSF46785 10 139 1.91E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 Pfam PF01047 MarR family 33 88 7.9E-14 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 Gene3D G3DSA:1.10.10.10 10 139 5.1E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 PANTHER PTHR33164 5 140 3.5E-15 T 21-04-2016 SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 PRINTS PR00598 Bacterial regulatory protein MarR family signature 66 81 2.2E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 PRINTS PR00598 Bacterial regulatory protein MarR family signature 115 135 2.2E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 PRINTS PR00598 Bacterial regulatory protein MarR family signature 85 101 2.2E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS13645 d11433492587153af9dd5c6e2a6000eb 143 PRINTS PR00598 Bacterial regulatory protein MarR family signature 49 65 2.2E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 1.1E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 1.1E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 1.1E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PANTHER PTHR24322 12 139 3.7E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PANTHER PTHR24322 155 183 3.7E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 252 3.4E-50 T 21-04-2016 SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 1.9E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 1.9E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 1.9E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 1.9E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.9E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 1.9E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8 188 0.0055 T 21-04-2016 SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 Gene3D G3DSA:3.40.50.720 1 253 1.8E-69 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03075 d811d841c91635839f34a1a7c1eae18a 263 SUPERFAMILY SSF51735 6 253 3.21E-70 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 PANTHER PTHR10799 495 968 4.3E-171 T 21-04-2016 SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 PANTHER PTHR10799 360 426 4.3E-171 T 21-04-2016 SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 PANTHER PTHR10799 61 122 4.3E-171 T 21-04-2016 SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 SMART SM00487 504 690 1.1E-27 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 SUPERFAMILY SSF52540 723 969 2.36E-67 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 Gene3D G3DSA:3.40.50.300 502 680 1.9E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 SUPERFAMILY SSF52540 470 722 7.6E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 Pfam PF00176 SNF2 family N-terminal domain 523 795 3.4E-64 T 21-04-2016 IPR000330 SNF2-related, N-terminal domain GO:0005524 SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 SMART SM00490 834 915 4.0E-21 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 Pfam PF00271 Helicase conserved C-terminal domain 812 915 3.5E-18 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS05320 9661234c0b6f19732a991f57f5e65c50 970 Gene3D G3DSA:3.40.50.300 801 942 2.6E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 PRINTS PR00598 Bacterial regulatory protein MarR family signature 69 84 1.6E-11 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 PRINTS PR00598 Bacterial regulatory protein MarR family signature 52 68 1.6E-11 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 PRINTS PR00598 Bacterial regulatory protein MarR family signature 88 104 1.6E-11 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 PRINTS PR00598 Bacterial regulatory protein MarR family signature 118 138 1.6E-11 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 SMART SM00347 28 128 6.5E-26 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 PANTHER PTHR33164 6 143 9.0E-29 T 21-04-2016 SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 Pfam PF12802 MarR family 34 92 4.0E-15 T 21-04-2016 SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 Gene3D G3DSA:1.10.10.10 4 143 3.6E-39 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14785 61f710c686a957a87fafb00970cca0f0 145 SUPERFAMILY SSF46785 7 143 1.57E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 PANTHER PTHR11669 8 421 1.2E-157 T 21-04-2016 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 SUPERFAMILY SSF48019 245 365 1.62E-20 T 21-04-2016 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: REACT_152|Reactome: REACT_1538|Reactome: REACT_216|Reactome: REACT_22172|Reactome: REACT_383 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 Gene3D G3DSA:1.10.8.60 168 241 1.6E-29 T 21-04-2016 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 Gene3D G3DSA:3.40.50.300 8 167 2.6E-64 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 42 60 1.52E-6 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 126 144 1.52E-6 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 TIGRFAM TIGR02397 dnaX_nterm: DNA polymerase III, subunit gamma and tau 6 360 1.1E-133 T 21-04-2016 IPR012763 DNA polymerase III, subunit gamma/ tau GO:0003887|GO:0005524|GO:0006260|GO:0009360 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 Gene3D G3DSA:1.20.272.10 245 363 4.3E-13 T 21-04-2016 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 SMART SM00382 38 181 5.7E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 Pfam PF13177 DNA polymerase III, delta subunit 21 180 2.7E-45 T 21-04-2016 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 Pfam PF12169 DNA polymerase III subunits gamma and tau domain III 237 366 6.5E-10 T 21-04-2016 IPR022754 DNA polymerase III, gamma subunit, domain III GO:0003887 SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 SUPERFAMILY SSF52540 34 223 3.58E-59 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11610 8235310210dbc94df87dd3a6a055cc14 595 PANTHER PTHR11669:SF0 8 421 1.2E-157 T 21-04-2016 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 Gene3D G3DSA:2.60.40.1120 29 118 2.9E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 Pfam PF07715 TonB-dependent Receptor Plug Domain 138 232 3.0E-14 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 SUPERFAMILY SSF56935 496 817 1.28E-115 T 21-04-2016 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 SUPERFAMILY SSF56935 100 463 1.28E-115 T 21-04-2016 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 Gene3D G3DSA:2.40.170.20 498 817 1.2E-125 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 Gene3D G3DSA:2.40.170.20 247 466 1.2E-125 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 SUPERFAMILY SSF49464 29 116 7.06E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 Pfam PF00593 TonB dependent receptor 578 815 1.7E-29 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 Gene3D G3DSA:2.170.130.10 119 239 2.2E-31 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 PANTHER PTHR32552:SF10 482 817 5.7E-119 T 21-04-2016 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 PANTHER PTHR32552:SF10 107 453 5.7E-119 T 21-04-2016 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 PANTHER PTHR32552 482 817 5.7E-119 T 21-04-2016 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 PANTHER PTHR32552 107 453 5.7E-119 T 21-04-2016 SPH21_RS13305 10cd1710ea45014ca69dc8446b935ed3 817 Pfam PF13715 CarboxypepD_reg-like domain 30 114 1.7E-18 T 21-04-2016 SPH21_RS07120 95a5542983288ce9eb7940f4103b87f7 128 ProSitePatterns PS00360 Ribosomal protein S9 signature. 67 85 - T 21-04-2016 IPR020574 Ribosomal protein S9, conserved site GO:0003735|GO:0005840|GO:0006412 SPH21_RS07120 95a5542983288ce9eb7940f4103b87f7 128 Gene3D G3DSA:3.30.230.10 4 128 5.9E-46 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS07120 95a5542983288ce9eb7940f4103b87f7 128 PANTHER PTHR21569 6 128 2.8E-56 T 21-04-2016 IPR000754 Ribosomal protein S9 GO:0003735|GO:0005840|GO:0006412 SPH21_RS07120 95a5542983288ce9eb7940f4103b87f7 128 SUPERFAMILY SSF54211 5 128 1.71E-43 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS07120 95a5542983288ce9eb7940f4103b87f7 128 Pfam PF00380 Ribosomal protein S9/S16 8 128 8.9E-45 T 21-04-2016 IPR000754 Ribosomal protein S9 GO:0003735|GO:0005840|GO:0006412 SPH21_RS22655 7592679a0efa12dba211fe6a8889600f 320 PIRSF PIRSF001365 5 311 3.0E-40 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22655 7592679a0efa12dba211fe6a8889600f 320 SUPERFAMILY SSF51569 9 301 3.35E-40 T 21-04-2016 SPH21_RS22655 7592679a0efa12dba211fe6a8889600f 320 PANTHER PTHR12128 1 318 2.5E-20 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22655 7592679a0efa12dba211fe6a8889600f 320 Pfam PF00701 Dihydrodipicolinate synthetase family 14 248 3.4E-14 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22655 7592679a0efa12dba211fe6a8889600f 320 Gene3D G3DSA:3.20.20.70 9 302 5.8E-42 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS22655 7592679a0efa12dba211fe6a8889600f 320 SMART SM01130 8 304 2.5E-18 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 Pfam PF13715 CarboxypepD_reg-like domain 27 106 9.8E-19 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 Gene3D G3DSA:2.60.40.1120 27 108 1.9E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 215 245 9.8E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 Gene3D G3DSA:2.170.130.10 109 242 2.7E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 Gene3D G3DSA:2.40.170.20 462 830 5.4E-28 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 Gene3D G3DSA:2.40.170.20 356 422 5.4E-28 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 Gene3D G3DSA:2.40.170.20 990 1064 5.4E-28 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 PANTHER PTHR11532:SF51 557 1106 1.3E-137 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 PANTHER PTHR11532:SF51 16 189 1.3E-137 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 PANTHER PTHR11532:SF51 206 474 1.3E-137 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 SUPERFAMILY SSF49464 26 104 1.44E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 SUPERFAMILY SSF56935 1014 1108 9.16E-71 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 SUPERFAMILY SSF56935 485 830 9.16E-71 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 SUPERFAMILY SSF56935 102 264 9.16E-71 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 SUPERFAMILY SSF56935 344 432 9.16E-71 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 SUPERFAMILY SSF56935 888 931 9.16E-71 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 1108 1.4E-169 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 239 9.5E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 PANTHER PTHR11532 557 1106 1.3E-137 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 PANTHER PTHR11532 16 189 1.3E-137 T 21-04-2016 SPH21_RS15590 55ad0e96550746eae7a6c385a0989f7f 1108 PANTHER PTHR11532 206 474 1.3E-137 T 21-04-2016 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 SUPERFAMILY SSF46689 227 276 1.7E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 227 269 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 Gene3D G3DSA:1.10.10.60 171 226 5.9E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 SUPERFAMILY SSF46689 174 224 9.56E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 PANTHER PTHR11019 151 281 3.8E-25 T 21-04-2016 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 PANTHER PTHR11019 1 133 3.8E-25 T 21-04-2016 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 Gene3D G3DSA:2.60.120.280 12 134 3.0E-11 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 Pfam PF12833 Helix-turn-helix domain 196 274 1.6E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 SMART SM00342 190 273 1.9E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 Pfam PF02311 AraC-like ligand binding domain 18 80 5.4E-10 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 Gene3D G3DSA:1.10.10.60 227 275 1.0E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22795 355768a939f4330f400ebabf72399d48 284 SUPERFAMILY SSF51215 19 105 3.27E-12 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 PANTHER PTHR30146 8 349 6.1E-50 T 21-04-2016 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 Pfam PF00356 Bacterial regulatory proteins, lacI family 13 56 1.9E-15 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 SUPERFAMILY SSF47413 10 66 6.99E-15 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 Gene3D G3DSA:3.40.50.2300 191 325 3.1E-13 T 21-04-2016 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 PANTHER PTHR30146:SF29 8 349 6.1E-50 T 21-04-2016 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 SMART SM00354 13 79 1.2E-13 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 Gene3D G3DSA:1.10.260.40 12 66 4.0E-20 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 SUPERFAMILY SSF53822 73 347 2.36E-28 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 Gene3D G3DSA:3.40.50.2300 67 190 1.2E-15 T 21-04-2016 SPH21_RS14115 cae37edb14b8a487e81477ffb357ff5e 352 Pfam PF13407 Periplasmic binding protein domain 72 324 4.0E-33 T 21-04-2016 IPR025997 Periplasmic binding protein SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 PANTHER PTHR33692 1 170 5.8E-22 T 21-04-2016 SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 SUPERFAMILY SSF50447 5 93 1.09E-10 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 Gene3D G3DSA:2.40.30.60 4 93 2.5E-9 T 21-04-2016 IPR002676 RimM protein GO:0006364 SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 Hamap MF_00014 Ribosome maturation factor RimM [rimM]. 6 168 17.962 T 21-04-2016 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 SUPERFAMILY SSF50346 99 168 9.16E-14 T 21-04-2016 IPR011033 PRC-barrel-like SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 TIGRFAM TIGR02273 16S_RimM: 16S rRNA processing protein RimM 7 168 1.0E-31 T 21-04-2016 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 Pfam PF01782 RimM N-terminal domain 9 89 6.0E-9 T 21-04-2016 IPR002676 RimM protein GO:0006364 SPH21_RS06525 6809707229946a5443aa96b6cc5f6a57 174 Gene3D G3DSA:2.30.30.240 99 168 4.5E-12 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 SMART SM00926 8 62 7.4E-16 T 21-04-2016 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 708 995 3.2E-47 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Pfam PF04324 BFD-like [2Fe-2S] binding domain 1112 1161 2.7E-10 T 21-04-2016 IPR007419 BFD-like [2Fe-2S]-binding domain SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 SUPERFAMILY SSF50692 556 701 6.56E-42 T 21-04-2016 IPR009010 Aspartate decarboxylase-like domain SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PANTHER PTHR11615:SF119 9 719 4.1E-224 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:3.40.50.740 66 143 1.4E-86 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:3.40.50.740 329 567 1.4E-86 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:3.50.50.60 811 930 4.1E-31 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:3.50.50.60 931 1006 1.4E-10 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:3.40.228.10 144 328 2.7E-61 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Pfam PF00384 Molybdopterin oxidoreductase 66 495 1.0E-77 T 21-04-2016 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 SUPERFAMILY SSF51905 706 891 2.67E-33 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:2.20.25.90 8 63 5.4E-18 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PANTHER PTHR11615 9 719 4.1E-224 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 ProSitePatterns PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 13 31 - T 21-04-2016 IPR027467 Molybdopterin oxidoreductase, molybdopterin cofactor binding site GO:0051539 KEGG: 00910+1.7.99.4 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 9 61 4.7E-15 T 21-04-2016 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Pfam PF01568 Molydopterin dinucleotide binding domain 584 696 6.6E-29 T 21-04-2016 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 SUPERFAMILY SSF53706 9 586 1.57E-186 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 SUPERFAMILY SSF51905 848 1006 2.09E-24 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 933 949 3.6E-19 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 804 822 3.6E-19 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 709 728 3.6E-19 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 958 980 3.6E-19 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 848 866 3.6E-19 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:2.40.40.20 576 701 1.7E-45 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 Gene3D G3DSA:3.50.50.60 706 810 2.9E-21 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 848 873 5.1E-12 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 934 948 5.1E-12 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 973 980 5.1E-12 T 21-04-2016 SPH21_RS18690 122ea454e0891b8650afa0da673ddb04 1169 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 708 730 5.1E-12 T 21-04-2016 SPH21_RS23615 e724cb97e3645869a9c73553924c7cd5 123 Pfam PF01638 HxlR-like helix-turn-helix 29 115 3.7E-23 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS23615 e724cb97e3645869a9c73553924c7cd5 123 PANTHER PTHR33204 8 122 6.5E-23 T 21-04-2016 SPH21_RS23615 e724cb97e3645869a9c73553924c7cd5 123 Gene3D G3DSA:1.10.10.10 16 120 4.1E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23615 e724cb97e3645869a9c73553924c7cd5 123 SUPERFAMILY SSF46785 21 118 1.8E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17975 7836a3323b9a885faba234b32859c621 111 SUPERFAMILY SSF46955 41 92 3.66E-8 T 21-04-2016 IPR009061 Putative DNA-binding domain SPH21_RS17975 7836a3323b9a885faba234b32859c621 111 PANTHER PTHR34585:SF15 2 101 1.1E-31 T 21-04-2016 SPH21_RS17975 7836a3323b9a885faba234b32859c621 111 Pfam PF12728 Helix-turn-helix domain 42 89 3.0E-7 T 21-04-2016 SPH21_RS17975 7836a3323b9a885faba234b32859c621 111 Gene3D G3DSA:1.10.10.10 42 90 2.6E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17975 7836a3323b9a885faba234b32859c621 111 PANTHER PTHR34585 2 101 1.1E-31 T 21-04-2016 SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 159 7.4E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 85 96 7.4E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 181 200 7.4E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 Gene3D G3DSA:3.40.50.720 3 253 5.9E-63 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 Pfam PF00106 short chain dehydrogenase 14 220 5.7E-47 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PANTHER PTHR24322 181 213 5.3E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PANTHER PTHR24322 17 155 5.3E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 168 196 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 14 31 1.0E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 1.0E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 202 219 1.0E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 161 1.0E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 200 1.0E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22005 8cef1f04cb508550e2a0becbb7b0fd26 257 SUPERFAMILY SSF51735 10 224 1.06E-55 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 Gene3D G3DSA:2.60.120.280 51 173 2.6E-4 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 282 298 7.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 267 282 7.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 PANTHER PTHR11019 192 298 8.7E-19 T 21-04-2016 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 Pfam PF12833 Helix-turn-helix domain 222 298 2.0E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 SMART SM00342 215 298 1.2E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 SUPERFAMILY SSF51215 48 172 2.62E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 Gene3D G3DSA:1.10.10.60 254 298 1.5E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 PANTHER PTHR11019:SF80 192 298 8.7E-19 T 21-04-2016 SPH21_RS23490 e4480c179ee4b44ba5e3891219360633 300 SUPERFAMILY SSF46689 255 298 3.18E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19815 44fd70c6fc1d22664dab9209aa3597af 233 Gene3D G3DSA:3.90.550.10 2 228 5.4E-62 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS19815 44fd70c6fc1d22664dab9209aa3597af 233 TIGRFAM TIGR00453 ispD: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 6 227 3.7E-57 T 21-04-2016 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS19815 44fd70c6fc1d22664dab9209aa3597af 233 PANTHER PTHR32125:SF4 1 228 9.3E-58 T 21-04-2016 SPH21_RS19815 44fd70c6fc1d22664dab9209aa3597af 233 Pfam PF01128 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 6 228 5.5E-50 T 21-04-2016 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS19815 44fd70c6fc1d22664dab9209aa3597af 233 SUPERFAMILY SSF53448 4 228 1.58E-51 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS19815 44fd70c6fc1d22664dab9209aa3597af 233 Hamap MF_00108 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [ispD]. 3 230 26.73 T 21-04-2016 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS19815 44fd70c6fc1d22664dab9209aa3597af 233 PANTHER PTHR32125 1 228 9.3E-58 T 21-04-2016 SPH21_RS03045 5329374def58137280543e214cd3f889 587 Gene3D G3DSA:3.20.14.10 339 587 7.1E-126 T 21-04-2016 IPR015888 L-fucose isomerase, C-terminal GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS03045 5329374def58137280543e214cd3f889 587 PANTHER PTHR37840 1 587 7.1E-227 T 21-04-2016 SPH21_RS03045 5329374def58137280543e214cd3f889 587 TIGRFAM TIGR01089 fucI: L-fucose isomerase 3 587 0.0 T 21-04-2016 IPR005763 L-fucose isomerase GO:0005737|GO:0008736|GO:0019317|GO:0030145 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS03045 5329374def58137280543e214cd3f889 587 SUPERFAMILY SSF50443 354 587 6.8E-123 T 21-04-2016 IPR004216 L-fucose/L-arabinose isomerase, C-terminal SPH21_RS03045 5329374def58137280543e214cd3f889 587 SUPERFAMILY SSF53743 2 353 5.75E-142 T 21-04-2016 IPR009015 L-fucose isomerase, N-terminal/central domain GO:0005737|GO:0005996|GO:0016861 SPH21_RS03045 5329374def58137280543e214cd3f889 587 Gene3D G3DSA:3.40.50.1070 1 173 4.0E-92 T 21-04-2016 IPR012888 L-fucose isomerase, N-terminal-1 GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS03045 5329374def58137280543e214cd3f889 587 PANTHER PTHR37840:SF1 1 587 7.1E-227 T 21-04-2016 SPH21_RS03045 5329374def58137280543e214cd3f889 587 Pfam PF07882 L-fucose isomerase, second N-terminal domain 173 352 1.2E-93 T 21-04-2016 IPR012889 L-fucose isomerase, N-terminal-2 GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS03045 5329374def58137280543e214cd3f889 587 Hamap MF_01254 L-fucose isomerase [fucI]. 1 587 68.049 T 21-04-2016 IPR005763 L-fucose isomerase GO:0005737|GO:0008736|GO:0019317|GO:0030145 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS03045 5329374def58137280543e214cd3f889 587 Gene3D G3DSA:3.40.275.10 174 338 8.4E-81 T 21-04-2016 IPR012889 L-fucose isomerase, N-terminal-2 GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS03045 5329374def58137280543e214cd3f889 587 Pfam PF02952 L-fucose isomerase, C-terminal domain 388 551 8.6E-53 T 21-04-2016 IPR015888 L-fucose isomerase, C-terminal GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS03045 5329374def58137280543e214cd3f889 587 Pfam PF07881 L-fucose isomerase, first N-terminal domain 4 172 4.0E-81 T 21-04-2016 IPR012888 L-fucose isomerase, N-terminal-1 GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 PANTHER PTHR19375 7 327 4.7E-151 T 21-04-2016 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 65 88 6.5E-48 T 21-04-2016 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 185 205 6.5E-48 T 21-04-2016 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 130 149 6.5E-48 T 21-04-2016 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 300 326 6.5E-48 T 21-04-2016 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 45 63 6.5E-48 T 21-04-2016 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 SUPERFAMILY SSF53067 148 337 4.35E-48 T 21-04-2016 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 Gene3D G3DSA:3.30.420.40 9 157 1.9E-40 T 21-04-2016 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 TIGRFAM TIGR00904 mreB: cell shape determining protein, MreB/Mrl family 7 332 1.5E-129 T 21-04-2016 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 PANTHER PTHR19375:SF117 7 327 4.7E-151 T 21-04-2016 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 SUPERFAMILY SSF53067 9 146 5.83E-35 T 21-04-2016 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 Gene3D G3DSA:3.90.640.10 185 258 2.6E-29 T 21-04-2016 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 Pfam PF06723 MreB/Mbl protein 9 332 3.1E-130 T 21-04-2016 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 Gene3D G3DSA:3.30.420.40 158 184 3.3E-32 T 21-04-2016 SPH21_RS11745 ae7f62a0e561313a3a376cfaaeef4e88 340 Gene3D G3DSA:3.30.420.40 263 317 3.3E-32 T 21-04-2016 SPH21_RS00020 e5e55f618a34090aaabb43522befaf99 148 Gene3D G3DSA:3.10.129.10 4 136 8.6E-33 T 21-04-2016 IPR029069 HotDog domain SPH21_RS00020 e5e55f618a34090aaabb43522befaf99 148 PANTHER PTHR31793 1 138 9.1E-30 T 21-04-2016 SPH21_RS00020 e5e55f618a34090aaabb43522befaf99 148 PANTHER PTHR31793:SF1 1 138 9.1E-30 T 21-04-2016 SPH21_RS00020 e5e55f618a34090aaabb43522befaf99 148 SUPERFAMILY SSF54637 11 136 2.57E-29 T 21-04-2016 IPR029069 HotDog domain SPH21_RS00020 e5e55f618a34090aaabb43522befaf99 148 Pfam PF13279 Thioesterase-like superfamily 19 131 1.3E-19 T 21-04-2016 SPH21_RS13035 92347d585bb71ceb422622c2f08371b3 196 Gene3D G3DSA:1.10.357.10 6 165 3.4E-20 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS13035 92347d585bb71ceb422622c2f08371b3 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 57 3.3E-9 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS13035 92347d585bb71ceb422622c2f08371b3 196 PANTHER PTHR30328 16 162 2.7E-13 T 21-04-2016 SPH21_RS13035 92347d585bb71ceb422622c2f08371b3 196 SUPERFAMILY SSF46689 3 82 2.05E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS17020 61766e07d4e5e763673b24d99d6fdbf8 350 Gene3D G3DSA:3.30.565.10 222 297 6.7E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS17020 61766e07d4e5e763673b24d99d6fdbf8 350 Pfam PF06580 Histidine kinase 161 235 1.9E-21 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS17020 61766e07d4e5e763673b24d99d6fdbf8 350 SUPERFAMILY SSF55874 224 324 2.55E-7 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS17020 61766e07d4e5e763673b24d99d6fdbf8 350 PANTHER PTHR34220:SF1 1 349 4.0E-55 T 21-04-2016 SPH21_RS17020 61766e07d4e5e763673b24d99d6fdbf8 350 PANTHER PTHR34220 1 349 4.0E-55 T 21-04-2016 SPH21_RS20655 ddf112d82bcb0de5cd2c106e7fff363b 190 SUPERFAMILY SSF51206 16 144 6.15E-21 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS20655 ddf112d82bcb0de5cd2c106e7fff363b 190 Gene3D G3DSA:2.60.120.10 2 155 1.1E-32 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS20655 ddf112d82bcb0de5cd2c106e7fff363b 190 PANTHER PTHR24567:SF33 14 187 4.1E-19 T 21-04-2016 SPH21_RS20655 ddf112d82bcb0de5cd2c106e7fff363b 190 PANTHER PTHR24567 14 187 4.1E-19 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 SUPERFAMILY SSF56935 442 790 2.64E-89 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 SUPERFAMILY SSF56935 856 900 2.64E-89 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 SUPERFAMILY SSF56935 939 997 2.64E-89 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 SUPERFAMILY SSF56935 115 257 2.64E-89 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 SUPERFAMILY SSF56935 314 402 2.64E-89 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 SUPERFAMILY SSF49464 37 119 3.4E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Gene3D G3DSA:2.60.40.1120 39 129 3.8E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Gene3D G3DSA:2.170.130.10 130 236 5.4E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 38 1025 1.2E-271 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 PANTHER PTHR11532 523 1023 4.8E-265 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 PANTHER PTHR11532 3 416 4.8E-265 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 PANTHER PTHR11532:SF57 523 1023 4.8E-265 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 PANTHER PTHR11532:SF57 3 416 4.8E-265 T 21-04-2016 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Gene3D G3DSA:2.40.170.20 323 811 1.1E-47 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Gene3D G3DSA:2.40.170.20 949 1023 1.1E-47 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Gene3D G3DSA:2.40.170.20 865 908 1.1E-47 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Gene3D G3DSA:2.40.170.20 237 253 1.1E-47 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Pfam PF07715 TonB-dependent Receptor Plug Domain 129 233 9.8E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 209 239 7.7E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23470 96b592a6f226f6c3c37d1c214d7d27c2 1025 Pfam PF13715 CarboxypepD_reg-like domain 39 121 1.2E-16 T 21-04-2016 SPH21_RS07815 0c0e75fcbeca56cdc96d912e0ca0bd05 115 Pfam PF01253 Translation initiation factor SUI1 37 109 2.8E-18 T 21-04-2016 IPR001950 Translation initiation factor SUI1 GO:0003743|GO:0006413 SPH21_RS07815 0c0e75fcbeca56cdc96d912e0ca0bd05 115 Gene3D G3DSA:3.30.780.10 36 115 1.5E-30 T 21-04-2016 IPR001950 Translation initiation factor SUI1 GO:0003743|GO:0006413 SPH21_RS07815 0c0e75fcbeca56cdc96d912e0ca0bd05 115 PIRSF PIRSF037511 1 115 5.5E-32 T 21-04-2016 IPR005872 Archaeal/bacterial translation initiation factor SUI1 GO:0003743 SPH21_RS07815 0c0e75fcbeca56cdc96d912e0ca0bd05 115 SUPERFAMILY SSF55159 37 114 6.8E-21 T 21-04-2016 IPR001950 Translation initiation factor SUI1 GO:0003743|GO:0006413 SPH21_RS07815 0c0e75fcbeca56cdc96d912e0ca0bd05 115 PANTHER PTHR12789 23 115 2.4E-16 T 21-04-2016 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 SUPERFAMILY SSF55545 18 155 4.34E-16 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 157 499 1.1E-120 T 21-04-2016 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PRINTS PR00738 Glycosyl hydrolase family 20 signature 116 136 3.8E-43 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PRINTS PR00738 Glycosyl hydrolase family 20 signature 151 168 3.8E-43 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PRINTS PR00738 Glycosyl hydrolase family 20 signature 319 332 3.8E-43 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PRINTS PR00738 Glycosyl hydrolase family 20 signature 257 274 3.8E-43 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PRINTS PR00738 Glycosyl hydrolase family 20 signature 463 479 3.8E-43 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PRINTS PR00738 Glycosyl hydrolase family 20 signature 180 201 3.8E-43 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PRINTS PR00738 Glycosyl hydrolase family 20 signature 481 498 3.8E-43 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 SUPERFAMILY SSF51445 157 512 5.12E-130 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 30 153 2.2E-13 T 21-04-2016 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 Gene3D G3DSA:2.60.120.260 657 754 8.8E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 Gene3D G3DSA:2.60.120.260 556 585 8.8E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 Pfam PF13290 Chitobiase/beta-hexosaminidase C-terminal domain 544 594 2.3E-12 T 21-04-2016 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 SUPERFAMILY SSF49785 658 745 7.73E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 Gene3D G3DSA:3.30.379.10 11 154 1.7E-19 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PANTHER PTHR22600 12 217 6.7E-232 T 21-04-2016 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PANTHER PTHR22600 240 655 6.7E-232 T 21-04-2016 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 Gene3D G3DSA:3.20.20.80 155 555 2.3E-142 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PANTHER PTHR22600:SF21 12 217 6.7E-232 T 21-04-2016 SPH21_RS05325 29d27e4ca507053911d539719f933e53 754 PANTHER PTHR22600:SF21 240 655 6.7E-232 T 21-04-2016 SPH21_RS12770 22148f2bdc608a7903acb713d6afd4a5 527 PANTHER PTHR10110 7 522 2.3E-93 T 21-04-2016 IPR018422 Cation/H+ exchanger, CPA1 family GO:0006812|GO:0015299|GO:0016021 Reactome: REACT_15518 SPH21_RS12770 22148f2bdc608a7903acb713d6afd4a5 527 TIGRFAM TIGR00831 a_cpa1: Na+/H+ antiporter 9 522 6.5E-105 T 21-04-2016 IPR004705 Cation/H+ exchanger, CPA1 family, bacteria GO:0006812|GO:0015299|GO:0016021 SPH21_RS12770 22148f2bdc608a7903acb713d6afd4a5 527 PANTHER PTHR10110:SF120 7 522 2.3E-93 T 21-04-2016 SPH21_RS12770 22148f2bdc608a7903acb713d6afd4a5 527 Pfam PF00999 Sodium/hydrogen exchanger family 11 408 7.2E-60 T 21-04-2016 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SPH21_RS01945 e9b8294832d19689451628cdf1e4ceea 364 Pfam PF03781 Sulfatase-modifying factor enzyme 1 68 359 5.8E-82 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS01945 e9b8294832d19689451628cdf1e4ceea 364 PANTHER PTHR23150 163 364 9.9E-97 T 21-04-2016 SPH21_RS01945 e9b8294832d19689451628cdf1e4ceea 364 PANTHER PTHR23150 64 146 9.9E-97 T 21-04-2016 SPH21_RS01945 e9b8294832d19689451628cdf1e4ceea 364 Gene3D G3DSA:3.90.1580.10 62 361 5.8E-96 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS01945 e9b8294832d19689451628cdf1e4ceea 364 SUPERFAMILY SSF56436 68 361 1.41E-90 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS13200 7478031cfefe974e95ea2f067197c398 171 Pfam PF03479 Domain of unknown function (DUF296) 42 149 2.1E-12 T 21-04-2016 IPR005175 PPC domain SPH21_RS13200 7478031cfefe974e95ea2f067197c398 171 Gene3D G3DSA:3.30.1330.80 34 169 5.7E-26 T 21-04-2016 SPH21_RS13200 7478031cfefe974e95ea2f067197c398 171 SUPERFAMILY SSF117856 34 166 5.75E-23 T 21-04-2016 SPH21_RS13200 7478031cfefe974e95ea2f067197c398 171 PANTHER PTHR34988 12 171 1.7E-20 T 21-04-2016 SPH21_RS09600 ebbc723ea72803e9c83811f35424c315 514 PANTHER PTHR30250:SF7 6 513 7.1E-52 T 21-04-2016 SPH21_RS09600 ebbc723ea72803e9c83811f35424c315 514 Pfam PF01554 MatE 29 174 4.9E-6 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS09600 ebbc723ea72803e9c83811f35424c315 514 PANTHER PTHR30250 6 513 7.1E-52 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 SUPERFAMILY SSF51735 35 205 1.31E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 251 278 0.025 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 45 172 2.5E-20 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 SUPERFAMILY SSF55347 239 325 8.28E-18 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 SUPERFAMILY SSF55347 179 207 8.28E-18 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 PANTHER PTHR22604:SF122 241 449 8.9E-72 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 PANTHER PTHR22604:SF122 3 207 8.9E-72 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 Gene3D G3DSA:3.30.360.10 246 346 1.8E-25 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 Gene3D G3DSA:3.30.360.10 186 212 1.8E-25 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 Gene3D G3DSA:3.30.360.10 386 440 1.8E-25 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 PANTHER PTHR22604 241 449 8.9E-72 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 PANTHER PTHR22604 3 207 8.9E-72 T 21-04-2016 SPH21_RS13630 c578c6bd5d2f5ed782c961ff45818bdb 449 Gene3D G3DSA:3.40.50.720 41 185 2.9E-33 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11540 3224bc96a0d6f299326f5a6b8bf3cecc 383 Gene3D G3DSA:3.40.190.10 138 313 2.4E-9 T 21-04-2016 SPH21_RS11540 3224bc96a0d6f299326f5a6b8bf3cecc 383 Pfam PF13416 Bacterial extracellular solute-binding protein 24 304 1.1E-7 T 21-04-2016 SPH21_RS11540 3224bc96a0d6f299326f5a6b8bf3cecc 383 Gene3D G3DSA:3.40.190.10 2 137 6.6E-19 T 21-04-2016 SPH21_RS11540 3224bc96a0d6f299326f5a6b8bf3cecc 383 SUPERFAMILY SSF53850 5 378 1.69E-33 T 21-04-2016 SPH21_RS20535 7816f809742cbc4d17d95429637e86ea 462 PANTHER PTHR30026:SF4 15 456 1.5E-55 T 21-04-2016 SPH21_RS20535 7816f809742cbc4d17d95429637e86ea 462 Gene3D G3DSA:1.20.1600.10 28 456 3.1E-77 T 21-04-2016 SPH21_RS20535 7816f809742cbc4d17d95429637e86ea 462 Pfam PF02321 Outer membrane efflux protein 37 225 9.7E-26 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS20535 7816f809742cbc4d17d95429637e86ea 462 Pfam PF02321 Outer membrane efflux protein 253 444 3.4E-25 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS20535 7816f809742cbc4d17d95429637e86ea 462 PANTHER PTHR30026 15 456 1.5E-55 T 21-04-2016 SPH21_RS20535 7816f809742cbc4d17d95429637e86ea 462 SUPERFAMILY SSF56954 5 457 2.22E-79 T 21-04-2016 SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 Pfam PF00106 short chain dehydrogenase 4 193 5.2E-55 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PIRSF PIRSF000126 1 266 1.4E-54 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4 187 1.3E-4 T 21-04-2016 SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 SUPERFAMILY SSF51735 1 260 4.78E-68 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 5.8E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 5.8E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 5.8E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 91 5.8E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 5.8E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 80 91 1.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 1.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 1.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PANTHER PTHR24322 152 184 2.9E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PANTHER PTHR24322 8 27 2.9E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 PANTHER PTHR24322 45 136 2.9E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15420 21806ef569ce01c9af6bc1df181663c0 270 Gene3D G3DSA:3.40.50.720 3 263 8.1E-71 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 SUPERFAMILY SSF54211 6 168 5.69E-34 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 PANTHER PTHR32039:SF7 1 507 5.7E-253 T 21-04-2016 IPR004482 Mg chelatase-related protein SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 Pfam PF13541 Subunit ChlI of Mg-chelatase 20 141 3.0E-43 T 21-04-2016 SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature 293 307 7.32E-7 T 21-04-2016 IPR001208 MCM domain GO:0003677|GO:0005524|GO:0006260 SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature 345 357 7.32E-7 T 21-04-2016 IPR001208 MCM domain GO:0003677|GO:0005524|GO:0006260 SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature 212 227 7.32E-7 T 21-04-2016 IPR001208 MCM domain GO:0003677|GO:0005524|GO:0006260 SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 PRINTS PR01657 Mini-chromosome maintenance (MCM) protein family signature 321 334 7.32E-7 T 21-04-2016 IPR001208 MCM domain GO:0003677|GO:0005524|GO:0006260 SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 Gene3D G3DSA:3.30.230.10 7 167 9.1E-31 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 TIGRFAM TIGR00368 TIGR00368: Mg chelatase-like protein 6 503 1.3E-198 T 21-04-2016 IPR004482 Mg chelatase-related protein SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 SUPERFAMILY SSF52540 191 423 1.69E-47 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 SUPERFAMILY SSF52540 466 506 1.69E-47 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 PANTHER PTHR32039 1 507 5.7E-253 T 21-04-2016 SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 Pfam PF01078 Magnesium chelatase, subunit ChlI 193 399 7.7E-99 T 21-04-2016 IPR000523 Magnesium chelatase ChlI domain SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 Gene3D G3DSA:3.40.50.300 192 392 8.1E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 Pfam PF13335 Magnesium chelatase, subunit ChlI C-terminal 407 503 1.3E-34 T 21-04-2016 IPR025158 Mg chelatase-related protein, C-terminal domain SPH21_RS07105 70d9a226b56d36832f7383e63e42617a 512 SMART SM00382 213 396 7.3E-6 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS21260 a75b429a9e49d1b7f117d11c8b7109e8 343 PANTHER PTHR33307 14 343 5.5E-103 T 21-04-2016 SPH21_RS21260 a75b429a9e49d1b7f117d11c8b7109e8 343 PANTHER PTHR33307:SF3 14 343 5.5E-103 T 21-04-2016 SPH21_RS21260 a75b429a9e49d1b7f117d11c8b7109e8 343 Pfam PF13088 BNR repeat-like domain 55 328 6.4E-87 T 21-04-2016 IPR011040 Sialidases SPH21_RS21260 a75b429a9e49d1b7f117d11c8b7109e8 343 SUPERFAMILY SSF50939 35 342 3.92E-55 T 21-04-2016 IPR011040 Sialidases SPH21_RS21260 a75b429a9e49d1b7f117d11c8b7109e8 343 Gene3D G3DSA:2.120.10.10 37 342 2.2E-65 T 21-04-2016 IPR011040 Sialidases SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 SMART SM00893 3 188 3.6E-18 T 21-04-2016 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: REACT_6305 SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 PANTHER PTHR10909 135 315 1.0E-41 T 21-04-2016 SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 PANTHER PTHR10909:SF299 135 315 1.0E-41 T 21-04-2016 SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 Gene3D G3DSA:3.40.50.1220 194 318 2.9E-52 T 21-04-2016 IPR029035 DHS-like NAD/FAD-binding domain SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 Gene3D G3DSA:3.40.50.620 1 188 3.2E-33 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 SUPERFAMILY SSF52402 1 186 9.77E-35 T 21-04-2016 SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 PIRSF PIRSF000089 1 323 3.8E-90 T 21-04-2016 IPR001308 Electron transfer flavoprotein alpha subunit/FixB GO:0009055|GO:0050660 SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 Pfam PF01012 Electron transfer flavoprotein domain 3 164 3.7E-27 T 21-04-2016 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: REACT_6305 SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 Pfam PF00766 Electron transfer flavoprotein FAD-binding domain 199 281 2.2E-32 T 21-04-2016 IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal SPH21_RS15230 8f2fb370d39213a4359d13508241689e 324 SUPERFAMILY SSF52467 196 317 3.51E-45 T 21-04-2016 IPR029035 DHS-like NAD/FAD-binding domain SPH21_RS15560 b3e43363f1d69db24f73c728406b9c35 281 Gene3D G3DSA:1.10.10.60 254 278 1.0E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS15560 b3e43363f1d69db24f73c728406b9c35 281 SMART SM00342 198 280 0.0063 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS15560 b3e43363f1d69db24f73c728406b9c35 281 Gene3D G3DSA:1.10.10.60 206 234 5.0E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS15560 b3e43363f1d69db24f73c728406b9c35 281 Pfam PF12833 Helix-turn-helix domain 208 278 8.1E-12 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS03965 932fd282ab8f3d7ff88ff667b7e648f7 323 PANTHER PTHR30273:SF2 1 321 9.1E-64 T 21-04-2016 SPH21_RS03965 932fd282ab8f3d7ff88ff667b7e648f7 323 PIRSF PIRSF018266 1 323 1.4E-57 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS03965 932fd282ab8f3d7ff88ff667b7e648f7 323 PANTHER PTHR30273 1 321 9.1E-64 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS03965 932fd282ab8f3d7ff88ff667b7e648f7 323 Pfam PF16344 Domain of unknown function (DUF4974) 221 319 1.2E-19 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS03965 932fd282ab8f3d7ff88ff667b7e648f7 323 Pfam PF04773 FecR protein 113 207 3.6E-21 T 21-04-2016 IPR006860 FecR protein SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 1050 9.3E-197 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Gene3D G3DSA:2.40.170.20 243 265 1.1E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Gene3D G3DSA:2.40.170.20 866 911 1.1E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Gene3D G3DSA:2.40.170.20 967 1049 1.1E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Gene3D G3DSA:2.40.170.20 327 786 1.1E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Pfam PF13715 CarboxypepD_reg-like domain 26 107 3.0E-16 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 SUPERFAMILY SSF56935 957 1050 1.8E-90 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 SUPERFAMILY SSF56935 434 779 1.8E-90 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 SUPERFAMILY SSF56935 318 406 1.8E-90 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 SUPERFAMILY SSF56935 858 901 1.8E-90 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 SUPERFAMILY SSF56935 103 265 1.8E-90 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 PANTHER PTHR11532 208 494 2.9E-187 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 PANTHER PTHR11532 571 1048 2.9E-187 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 PANTHER PTHR11532 12 192 2.9E-187 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 SUPERFAMILY SSF49464 25 105 1.27E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 217 247 5.0E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 PANTHER PTHR11532:SF51 208 494 2.9E-187 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 PANTHER PTHR11532:SF51 571 1048 2.9E-187 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 PANTHER PTHR11532:SF51 12 192 2.9E-187 T 21-04-2016 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Gene3D G3DSA:2.170.130.10 109 242 3.7E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 241 1.2E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22440 4415c790d0467fc0dfb9f7a008ab0ca4 1050 Gene3D G3DSA:2.60.40.1120 25 108 2.3E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 Pfam PF00072 Response regulator receiver domain 5 116 2.4E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 1.1E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 1.1E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 1.1E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 PANTHER PTHR26402 3 211 1.7E-54 T 21-04-2016 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 SMART SM00448 3 116 1.3E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 Gene3D G3DSA:1.10.10.10 161 214 2.5E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 210 1.2E-15 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 PANTHER PTHR26402:SF151 3 211 1.7E-54 T 21-04-2016 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 SUPERFAMILY SSF52172 2 132 1.57E-25 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 SUPERFAMILY SSF46894 149 214 1.73E-17 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 Gene3D G3DSA:3.40.50.2300 2 160 9.7E-31 T 21-04-2016 SPH21_RS23815 854e2dbf33aba0a9357987eea86d0aed 216 SMART SM00421 153 210 5.5E-19 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 Gene3D G3DSA:1.10.10.60 216 261 3.2E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 Gene3D G3DSA:3.40.50.880 5 215 5.1E-48 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 Pfam PF12833 Helix-turn-helix domain 231 310 4.7E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 PANTHER PTHR11019 84 316 3.9E-83 T 21-04-2016 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 Pfam PF01965 DJ-1/PfpI family 30 170 3.5E-20 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 SMART SM00342 225 308 1.9E-25 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 Gene3D G3DSA:1.10.10.60 262 311 5.0E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 SUPERFAMILY SSF46689 261 312 2.24E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 262 304 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 SUPERFAMILY SSF46689 209 258 4.48E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 SUPERFAMILY SSF52317 4 189 9.47E-39 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS25055 9dff08fc6715fdf57377dd3ea7912ac3 316 PANTHER PTHR11019:SF58 84 316 3.9E-83 T 21-04-2016 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 Gene3D G3DSA:3.40.50.2300 5 129 2.0E-22 T 21-04-2016 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 SMART SM00850 147 242 1.6E-17 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 PANTHER PTHR26402:SF522 10 122 5.7E-24 T 21-04-2016 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 SUPERFAMILY SSF52172 9 127 4.55E-22 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 Gene3D G3DSA:2.40.50.40 140 208 4.1E-17 T 21-04-2016 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 Pfam PF00072 Response regulator receiver domain 13 119 9.9E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 PANTHER PTHR26402 10 122 5.7E-24 T 21-04-2016 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 SMART SM00448 10 118 7.5E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS16980 233034d114af54df3ef6b766116e5e93 248 Pfam PF04397 LytTr DNA-binding domain 148 241 8.7E-15 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 Pfam PF00005 ABC transporter 18 187 1.3E-27 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 Pfam PF00005 ABC transporter 338 469 4.1E-19 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 Pfam PF16326 ABC transporter C-terminal domain 568 632 2.8E-10 T 21-04-2016 IPR032524 ABC transporter Uup, C-terminal GO:0003677 SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 SMART SM00382 347 514 3.9E-7 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 SMART SM00382 26 231 1.1E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 Pfam PF12848 ABC transporter 227 310 4.2E-28 T 21-04-2016 IPR032781 ABC-transporter extension domain SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 Gene3D G3DSA:3.40.50.300 321 548 8.7E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 Gene3D G3DSA:3.40.50.300 1 274 1.9E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 PANTHER PTHR19211 1 570 7.5E-228 T 21-04-2016 SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 ProSitePatterns PS00211 ABC transporters family signature. 441 455 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 SUPERFAMILY SSF52540 128 265 5.09E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 SUPERFAMILY SSF52540 2 92 5.09E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17600 ca30246e797c304f361737cac14c847c 641 SUPERFAMILY SSF52540 302 530 3.61E-47 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 SUPERFAMILY SSF56935 113 781 1.25E-81 T 21-04-2016 SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 Gene3D G3DSA:2.60.40.1120 27 107 2.9E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 Gene3D G3DSA:2.170.130.10 109 229 1.3E-27 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 Pfam PF00593 TonB dependent receptor 533 780 8.5E-18 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 PANTHER PTHR32552:SF0 98 781 1.3E-71 T 21-04-2016 SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 PANTHER PTHR32552 98 781 1.3E-71 T 21-04-2016 SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 Pfam PF07715 TonB-dependent Receptor Plug Domain 126 229 1.9E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 Gene3D G3DSA:2.40.170.20 230 781 4.2E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 SUPERFAMILY SSF49464 27 125 6.28E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13270 a5ef457831236bff1dda172ee940f484 781 Pfam PF13715 CarboxypepD_reg-like domain 27 116 3.2E-13 T 21-04-2016 SPH21_RS04425 597a86630022eef5e82fe5ec3fa14d81 184 Gene3D G3DSA:3.40.50.300 2 178 1.2E-28 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04425 597a86630022eef5e82fe5ec3fa14d81 184 SUPERFAMILY SSF52540 1 178 3.46E-25 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04425 597a86630022eef5e82fe5ec3fa14d81 184 Pfam PF13238 AAA domain 7 131 4.2E-11 T 21-04-2016 SPH21_RS20720 25c8249000ee168935984688e111e784 199 SUPERFAMILY SSF88946 20 96 1.92E-18 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20720 25c8249000ee168935984688e111e784 199 Gene3D G3DSA:1.10.1740.10 21 105 2.3E-19 T 21-04-2016 SPH21_RS20720 25c8249000ee168935984688e111e784 199 TIGRFAM TIGR02943 Sig70_famx1: RNA polymerase sigma-70 factor, TIGR02943 family 27 199 1.9E-48 T 21-04-2016 IPR014289 RNA polymerase sigma-24-related SPH21_RS20720 25c8249000ee168935984688e111e784 199 Pfam PF04542 Sigma-70 region 2 21 87 2.2E-12 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20720 25c8249000ee168935984688e111e784 199 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 21 194 3.4E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20720 25c8249000ee168935984688e111e784 199 PANTHER PTHR30173 22 197 1.9E-28 T 21-04-2016 SPH21_RS20720 25c8249000ee168935984688e111e784 199 PANTHER PTHR30173:SF24 22 197 1.9E-28 T 21-04-2016 SPH21_RS20720 25c8249000ee168935984688e111e784 199 SUPERFAMILY SSF88659 108 197 3.71E-7 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS20720 25c8249000ee168935984688e111e784 199 Gene3D G3DSA:1.10.10.10 131 196 1.0E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11725 db1075e5f5342484c3db3bcd8b25281d 421 PANTHER PTHR30474 11 207 2.9E-120 T 21-04-2016 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SPH21_RS11725 db1075e5f5342484c3db3bcd8b25281d 421 PANTHER PTHR30474 256 418 2.9E-120 T 21-04-2016 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SPH21_RS11725 db1075e5f5342484c3db3bcd8b25281d 421 TIGRFAM TIGR02210 rodA_shape: rod shape-determining protein RodA 13 417 3.0E-107 T 21-04-2016 IPR011923 Rod shape-determining protein RodA GO:0008360|GO:0016021 SPH21_RS11725 db1075e5f5342484c3db3bcd8b25281d 421 PANTHER PTHR30474:SF1 11 207 2.9E-120 T 21-04-2016 IPR011923 Rod shape-determining protein RodA GO:0008360|GO:0016021 SPH21_RS11725 db1075e5f5342484c3db3bcd8b25281d 421 PANTHER PTHR30474:SF1 256 418 2.9E-120 T 21-04-2016 IPR011923 Rod shape-determining protein RodA GO:0008360|GO:0016021 SPH21_RS11725 db1075e5f5342484c3db3bcd8b25281d 421 Pfam PF01098 Cell cycle protein 194 417 7.6E-56 T 21-04-2016 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SPH21_RS11725 db1075e5f5342484c3db3bcd8b25281d 421 ProSitePatterns PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 375 399 - T 21-04-2016 IPR018365 Cell cycle, FtsW / RodA / SpoVE, conserved site GO:0007049|GO:0016021 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 Pfam PF00326 Prolyl oligopeptidase family 491 703 4.1E-65 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 Gene3D G3DSA:2.130.10.120 101 435 3.5E-99 T 21-04-2016 IPR023302 Peptidase S9A, N-terminal domain GO:0004252|GO:0070008 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 SUPERFAMILY SSF50993 25 439 1.12E-88 T 21-04-2016 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PANTHER PTHR11757 14 709 4.4E-303 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PANTHER PTHR11757:SF3 14 709 4.4E-303 T 21-04-2016 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 Gene3D G3DSA:3.40.50.1820 449 674 4.3E-33 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 SUPERFAMILY SSF53474 443 690 6.12E-42 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 559 579 5.1E-55 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 529 548 5.1E-55 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 635 657 5.1E-55 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 617 632 5.1E-55 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 501 525 5.1E-55 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 475 493 5.1E-55 T 21-04-2016 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SPH21_RS06125 1587786fbfe7afdc301c1a859f8e6f42 709 Pfam PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 28 432 2.2E-100 T 21-04-2016 IPR023302 Peptidase S9A, N-terminal domain GO:0004252|GO:0070008 SPH21_RS16815 9713db64ce395f49db3171c22f8a4761 239 Gene3D G3DSA:3.40.190.10 1 76 9.1E-34 T 21-04-2016 SPH21_RS16815 9713db64ce395f49db3171c22f8a4761 239 Gene3D G3DSA:3.40.190.10 164 238 9.1E-34 T 21-04-2016 SPH21_RS16815 9713db64ce395f49db3171c22f8a4761 239 SUPERFAMILY SSF53850 4 236 7.6E-59 T 21-04-2016 SPH21_RS16815 9713db64ce395f49db3171c22f8a4761 239 Pfam PF02621 Menaquinone biosynthesis 4 237 1.5E-44 T 21-04-2016 IPR003773 Menaquinone biosynthesis enzyme UniPathway: UPA00079 SPH21_RS16815 9713db64ce395f49db3171c22f8a4761 239 Hamap MF_00995 Chorismate dehydratase [mqnA]. 5 239 20.185 T 21-04-2016 IPR030868 Chorismate dehydratase GO:0009234|GO:0016829 KEGG: 00130+4.2.1.151|MetaCyc: PWY-7371|MetaCyc: PWY-7374|UniPathway: UPA00079 SPH21_RS16815 9713db64ce395f49db3171c22f8a4761 239 PANTHER PTHR37690 1 239 7.8E-36 T 21-04-2016 SPH21_RS16815 9713db64ce395f49db3171c22f8a4761 239 Gene3D G3DSA:3.40.190.10 77 163 3.7E-22 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 Gene3D G3DSA:3.30.2090.10 184 272 8.2E-27 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82693 39 134 1.1E-26 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82866 832 1029 5.89E-44 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82693 275 329 1.31E-22 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82693 136 183 1.31E-22 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 3 1039 0.0 T 21-04-2016 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0005215|GO:0006810|GO:0016021 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 Pfam PF00873 AcrB/AcrD/AcrF family 2 1028 0.0 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 471 494 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 337 360 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 555 572 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 625 639 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 392 416 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 9 33 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 37 55 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 446 469 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PRINTS PR00702 Acriflavin resistance protein family signature 364 385 1.7E-93 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82693 568 672 4.19E-24 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 Gene3D G3DSA:3.30.2090.10 722 806 1.7E-20 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PANTHER PTHR32063:SF11 1 1048 0.0 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82866 297 498 6.02E-49 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 Gene3D G3DSA:3.30.70.1430 39 140 1.8E-32 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 Gene3D G3DSA:1.10.3850.10 814 1030 4.4E-56 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82714 723 806 1.44E-19 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82714 185 272 3.53E-22 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 Gene3D G3DSA:1.20.1640.10 292 505 5.1E-58 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 PANTHER PTHR32063 1 1048 0.0 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 Gene3D G3DSA:3.30.70.1430 571 672 6.3E-27 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82693 673 722 1.2E-23 T 21-04-2016 SPH21_RS18100 2768d9ffc10ef35bd9dbd04f2863e2a7 1058 SUPERFAMILY SSF82693 809 858 1.2E-23 T 21-04-2016 SPH21_RS24880 cd9247315f0821cc350e613999e232bc 340 PANTHER PTHR30137:SF3 1 340 3.5E-215 T 21-04-2016 SPH21_RS24880 cd9247315f0821cc350e613999e232bc 340 Pfam PF00296 Luciferase-like monooxygenase 10 250 1.1E-21 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS24880 cd9247315f0821cc350e613999e232bc 340 Gene3D G3DSA:3.20.20.30 3 340 3.9E-54 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS24880 cd9247315f0821cc350e613999e232bc 340 PANTHER PTHR30137 1 340 3.5E-215 T 21-04-2016 SPH21_RS24880 cd9247315f0821cc350e613999e232bc 340 SUPERFAMILY SSF51679 7 333 3.53E-50 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 PANTHER PTHR11019 30 268 5.6E-35 T 21-04-2016 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 SUPERFAMILY SSF46689 160 211 3.4E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 Pfam PF12833 Helix-turn-helix domain 183 261 5.4E-23 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 SUPERFAMILY SSF46689 213 262 5.82E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 SMART SM00342 177 260 6.9E-27 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 SUPERFAMILY SSF51182 29 138 1.33E-7 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 Pfam PF02311 AraC-like ligand binding domain 18 90 2.0E-8 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 244 260 1.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 229 244 1.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 PANTHER PTHR11019:SF53 30 268 5.6E-35 T 21-04-2016 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 Gene3D G3DSA:2.60.120.280 28 81 2.0E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 Gene3D G3DSA:1.10.10.60 159 213 4.1E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08480 2ca634d2f1d59406ef7b6b2ac775704b 271 Gene3D G3DSA:1.10.10.60 214 262 1.3E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 PANTHER PTHR24423 91 333 2.3E-37 T 21-04-2016 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 SMART SM00387 225 333 1.4E-20 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 Gene3D G3DSA:1.10.287.130 114 177 1.9E-5 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 SUPERFAMILY SSF55874 180 333 1.18E-32 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 Pfam PF00571 CBS domain 64 113 6.1E-8 T 21-04-2016 IPR000644 CBS domain SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 PRINTS PR00344 Bacterial sensor protein C-terminal signature 280 290 3.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 PRINTS PR00344 Bacterial sensor protein C-terminal signature 262 276 3.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 PRINTS PR00344 Bacterial sensor protein C-terminal signature 321 333 3.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 PRINTS PR00344 Bacterial sensor protein C-terminal signature 297 315 3.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 226 332 2.2E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 Gene3D G3DSA:3.10.580.10 4 113 1.0E-10 T 21-04-2016 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 SMART SM00116 12 58 26.0 T 21-04-2016 IPR000644 CBS domain SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 SMART SM00116 67 114 0.011 T 21-04-2016 IPR000644 CBS domain SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 Gene3D G3DSA:3.30.565.10 186 333 1.3E-33 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 SUPERFAMILY SSF54631 4 116 2.33E-14 T 21-04-2016 SPH21_RS26420 082bea4143cf3183a1e66a55cb73c89f 333 SUPERFAMILY SSF47384 104 178 2.94E-6 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS16405 e294ac3e9e0139ff1b9587b162e9e526 154 PANTHER PTHR10642 1 134 4.3E-46 T 21-04-2016 SPH21_RS16405 e294ac3e9e0139ff1b9587b162e9e526 154 SUPERFAMILY SSF53098 1 135 9.36E-48 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS16405 e294ac3e9e0139ff1b9587b162e9e526 154 Pfam PF00075 RNase H 3 134 1.2E-35 T 21-04-2016 IPR002156 Ribonuclease H domain GO:0003676|GO:0004523 SPH21_RS16405 e294ac3e9e0139ff1b9587b162e9e526 154 Gene3D G3DSA:3.30.420.10 2 137 1.3E-45 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 Gene3D G3DSA:3.40.50.720 109 288 6.6E-51 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 4 311 1.3E-25 T 21-04-2016 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 PANTHER PTHR10996:SF20 1 307 2.9E-83 T 21-04-2016 SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 SUPERFAMILY SSF51735 97 286 2.21E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 SUPERFAMILY SSF52283 1 133 1.06E-29 T 21-04-2016 SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 Gene3D G3DSA:3.40.50.720 1 108 1.2E-30 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 PANTHER PTHR10996 1 307 2.9E-83 T 21-04-2016 SPH21_RS00030 0be09ef567765efe4763869ed32f296d 316 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 106 285 3.1E-45 T 21-04-2016 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 Hamap MF_00948 Transcription termination/antitermination protein NusG [nusG]. 5 181 21.269 T 21-04-2016 IPR001062 Transcription antitermination protein, NusG GO:0032784 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 Pfam PF02357 Transcription termination factor nusG 7 111 1.8E-18 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 SMART SM00739 127 154 2.8E-4 T 21-04-2016 IPR005824 KOW SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 SMART SM00738 5 114 1.3E-24 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 PANTHER PTHR30265 1 180 1.4E-48 T 21-04-2016 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 TIGRFAM TIGR00922 nusG: transcription termination/antitermination factor NusG 8 180 1.7E-52 T 21-04-2016 IPR001062 Transcription antitermination protein, NusG GO:0032784 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 Pfam PF00467 KOW motif 130 164 6.9E-7 T 21-04-2016 IPR005824 KOW SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 Gene3D G3DSA:3.30.70.940 7 116 1.3E-32 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 PRINTS PR00338 Transcription termination factor NUSG signature 139 154 4.4E-17 T 21-04-2016 IPR001062 Transcription antitermination protein, NusG GO:0032784 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 PRINTS PR00338 Transcription termination factor NUSG signature 157 173 4.4E-17 T 21-04-2016 IPR001062 Transcription antitermination protein, NusG GO:0032784 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 PRINTS PR00338 Transcription termination factor NUSG signature 60 72 4.4E-17 T 21-04-2016 IPR001062 Transcription antitermination protein, NusG GO:0032784 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 Gene3D G3DSA:2.30.30.30 124 180 6.3E-27 T 21-04-2016 IPR014722 Ribosomal protein L2 domain 2 SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 SUPERFAMILY SSF50104 101 180 2.88E-18 T 21-04-2016 IPR008991 Translation protein SH3-like domain SPH21_RS11880 859393fb8671616635a2017febff8c2b 181 SUPERFAMILY SSF82679 6 115 3.14E-28 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS01615 834f432b56aa3d7521c4fa0a5a5c993c 289 SUPERFAMILY SSF56317 1 283 1.57E-90 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS01615 834f432b56aa3d7521c4fa0a5a5c993c 289 Gene3D G3DSA:3.60.110.10 1 283 1.0E-101 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS01615 834f432b56aa3d7521c4fa0a5a5c993c 289 PANTHER PTHR23088 1 284 1.0E-142 T 21-04-2016 SPH21_RS01615 834f432b56aa3d7521c4fa0a5a5c993c 289 Pfam PF00795 Carbon-nitrogen hydrolase 6 260 9.6E-61 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS01615 834f432b56aa3d7521c4fa0a5a5c993c 289 PANTHER PTHR23088:SF11 1 284 1.0E-142 T 21-04-2016 SPH21_RS21925 c30d906bf6550507efaf180e06cac2b1 188 Gene3D G3DSA:2.60.120.10 1 154 1.6E-29 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS21925 c30d906bf6550507efaf180e06cac2b1 188 Pfam PF00027 Cyclic nucleotide-binding domain 29 113 7.9E-7 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS21925 c30d906bf6550507efaf180e06cac2b1 188 SUPERFAMILY SSF51206 5 114 4.98E-17 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS21925 c30d906bf6550507efaf180e06cac2b1 188 PANTHER PTHR24567 10 188 3.2E-21 T 21-04-2016 SPH21_RS21925 c30d906bf6550507efaf180e06cac2b1 188 PANTHER PTHR24567:SF33 10 188 3.2E-21 T 21-04-2016 SPH21_RS15295 ea73b25840fc7baa33107b1c577fdc05 254 SMART SM00740 109 179 0.0012 T 21-04-2016 IPR005543 PASTA domain SPH21_RS15295 ea73b25840fc7baa33107b1c577fdc05 254 SMART SM00740 41 107 4.2E-9 T 21-04-2016 IPR005543 PASTA domain SPH21_RS15295 ea73b25840fc7baa33107b1c577fdc05 254 SMART SM00740 182 254 0.0017 T 21-04-2016 IPR005543 PASTA domain SPH21_RS15295 ea73b25840fc7baa33107b1c577fdc05 254 Pfam PF03793 PASTA domain 45 105 4.7E-13 T 21-04-2016 IPR005543 PASTA domain SPH21_RS15295 ea73b25840fc7baa33107b1c577fdc05 254 Pfam PF03793 PASTA domain 113 178 2.8E-5 T 21-04-2016 IPR005543 PASTA domain SPH21_RS15295 ea73b25840fc7baa33107b1c577fdc05 254 Pfam PF03793 PASTA domain 186 253 1.0E-9 T 21-04-2016 IPR005543 PASTA domain SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 TIGRFAM TIGR03150 fabF: beta-ketoacyl-acyl-carrier-protein synthase II 4 413 3.6E-181 T 21-04-2016 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 UniPathway: UPA00094 SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 SUPERFAMILY SSF53901 215 415 4.87E-67 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4 248 2.6E-55 T 21-04-2016 IPR014030 Beta-ketoacyl synthase, N-terminal SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 Gene3D G3DSA:3.40.47.10 264 416 2.8E-57 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 PANTHER PTHR11712 4 416 7.0E-186 T 21-04-2016 SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 SUPERFAMILY SSF53901 4 253 1.03E-73 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 156 172 - T 21-04-2016 IPR018201 Beta-ketoacyl synthase, active site SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 SMART SM00825 Beta-ketoacyl synthase 6 417 3.2E-15 T 21-04-2016 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 Gene3D G3DSA:3.40.47.10 8 261 6.6E-75 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 256 369 2.7E-33 T 21-04-2016 IPR014031 Beta-ketoacyl synthase, C-terminal SPH21_RS06680 89633062021d0aacf3064b3b8c990fd8 417 PIRSF PIRSF000447 1 417 5.6E-170 T 21-04-2016 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 UniPathway: UPA00094 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 SUPERFAMILY SSF56519 49 234 4.45E-21 T 21-04-2016 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 PANTHER PTHR30627 10 576 1.7E-126 T 21-04-2016 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 PANTHER PTHR30627:SF1 10 576 1.7E-126 T 21-04-2016 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 Pfam PF03793 PASTA domain 640 692 1.1E-8 T 21-04-2016 IPR005543 PASTA domain SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 SUPERFAMILY SSF54184 640 692 4.97E-9 T 21-04-2016 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 SUPERFAMILY SSF56601 190 593 9.52E-80 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 Pfam PF03717 Penicillin-binding Protein dimerisation domain 54 182 5.1E-10 T 21-04-2016 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 SMART SM00740 636 693 0.0018 T 21-04-2016 IPR005543 PASTA domain SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 Gene3D G3DSA:3.90.1310.10 159 243 3.7E-15 T 21-04-2016 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 Pfam PF00905 Penicillin binding protein transpeptidase domain 262 571 2.5E-58 T 21-04-2016 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SPH21_RS00300 939cc3aacf0339f3102ebd131561cf0a 693 Gene3D G3DSA:3.40.710.10 244 576 1.2E-81 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS16180 a16dea12d30086a2144d82d86588f892 422 Pfam PF05684 Protein of unknown function (DUF819) 19 416 6.3E-91 T 21-04-2016 IPR008537 Protein of unknown function DUF819 SPH21_RS16180 a16dea12d30086a2144d82d86588f892 422 PANTHER PTHR34289 1 418 1.6E-80 T 21-04-2016 SPH21_RS16180 a16dea12d30086a2144d82d86588f892 422 PANTHER PTHR34289:SF3 1 418 1.6E-80 T 21-04-2016 SPH21_RS16180 a16dea12d30086a2144d82d86588f892 422 PRINTS PR00173 Glutamate-aspartate symporter signature 225 247 2.7E-5 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16180 a16dea12d30086a2144d82d86588f892 422 PRINTS PR00173 Glutamate-aspartate symporter signature 101 126 2.7E-5 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16180 a16dea12d30086a2144d82d86588f892 422 PRINTS PR00173 Glutamate-aspartate symporter signature 6 26 2.7E-5 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16180 a16dea12d30086a2144d82d86588f892 422 PRINTS PR00173 Glutamate-aspartate symporter signature 361 387 2.7E-5 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 SUPERFAMILY SSF111369 167 279 8.11E-13 T 21-04-2016 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 Pfam PF00529 HlyD membrane-fusion protein of T1SS 22 343 1.9E-10 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 PANTHER PTHR30386:SF0 17 345 7.1E-79 T 21-04-2016 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 SUPERFAMILY SSF111369 53 104 1.14E-5 T 21-04-2016 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 SUPERFAMILY SSF111369 121 180 2.88E-6 T 21-04-2016 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 51 296 8.5E-20 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 Gene3D G3DSA:2.40.50.100 54 84 8.9E-20 T 21-04-2016 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 Gene3D G3DSA:2.40.50.100 215 247 8.9E-20 T 21-04-2016 SPH21_RS04375 b4820d06e109228ef96b5208a38f4128 348 PANTHER PTHR30386 17 345 7.1E-79 T 21-04-2016 SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 TIGRFAM TIGR00195 exoDNase_III: exodeoxyribonuclease III 1 255 1.9E-75 T 21-04-2016 SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 Gene3D G3DSA:3.60.10.10 1 256 2.7E-82 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 PANTHER PTHR22748:SF9 1 256 9.9E-145 T 21-04-2016 SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 ProSitePatterns PS00726 AP endonucleases family 1 signature 1. 27 36 - T 21-04-2016 IPR020847 AP endonuclease 1, binding site GO:0003677|GO:0004519|GO:0005622|GO:0006281 SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 SUPERFAMILY SSF56219 1 256 1.19E-81 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 TIGRFAM TIGR00633 xth: exodeoxyribonuclease III (xth) 1 255 1.1E-71 T 21-04-2016 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 PANTHER PTHR22748 1 256 9.9E-145 T 21-04-2016 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 SPH21_RS22335 5a0a5305c1870d0f3e5a62bcb582c9a7 259 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 4 248 3.5E-22 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Gene3D G3DSA:3.40.1110.10 453 567 2.1E-20 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Gene3D G3DSA:2.70.150.10 198 337 1.9E-31 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 587 597 5.0E-20 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 438 452 5.0E-20 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 640 659 5.0E-20 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 663 675 5.0E-20 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 286 300 5.0E-20 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Gene3D G3DSA:3.30.70.100 16 85 2.7E-21 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Gene3D G3DSA:3.40.50.1000 568 708 5.5E-55 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Gene3D G3DSA:3.40.50.1000 409 452 5.5E-55 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 SUPERFAMILY SSF56784 497 747 1.12E-60 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 SUPERFAMILY SSF56784 437 456 1.12E-60 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Pfam PF00403 Heavy-metal-associated domain 25 83 8.0E-13 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PANTHER PTHR24093 15 753 2.2E-257 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PANTHER PTHR24093:SF50 15 753 2.2E-257 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 149 750 2.7E-184 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 ProSitePatterns PS01047 Heavy-metal-associated domain. 25 54 - T 21-04-2016 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 SUPERFAMILY SSF81665 689 711 2.48E-12 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 SUPERFAMILY SSF81665 202 237 2.48E-12 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 SUPERFAMILY SSF81665 337 431 2.48E-12 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 SUPERFAMILY SSF55008 15 85 3.4E-19 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00943 Copper-transporting ATPase signature 617 634 3.2E-16 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00943 Copper-transporting ATPase signature 206 225 3.2E-16 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00943 Copper-transporting ATPase signature 152 171 3.2E-16 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00943 Copper-transporting ATPase signature 713 727 3.2E-16 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00943 Copper-transporting ATPase signature 421 436 3.2E-16 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00943 Copper-transporting ATPase signature 359 373 3.2E-16 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 PRINTS PR00943 Copper-transporting ATPase signature 674 688 3.2E-16 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 167 749 1.5E-195 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 209 718 5.1E-93 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 440 446 - T 21-04-2016 IPR018303 P-type ATPase, phosphorylation site SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Pfam PF00702 haloacid dehalogenase-like hydrolase 434 654 8.7E-46 T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 ProSitePatterns PS01229 Hypothetical cof family signature 2. 640 662 - T 21-04-2016 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 Pfam PF00122 E1-E2 ATPase 207 429 4.4E-68 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS01370 a80d0f54d9ee4d896c57acc9994c8aa7 753 SUPERFAMILY SSF81653 239 336 8.11E-28 T 21-04-2016 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 SUPERFAMILY SSF52540 60 350 8.17E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 SMART SM00487 16 216 2.0E-34 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Pfam PF00271 Helicase conserved C-terminal domain 223 329 1.0E-17 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Pfam PF00270 DEAD/DEAH box helicase 24 186 2.2E-22 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Pfam PF00570 HRDC domain 535 601 2.7E-18 T 21-04-2016 IPR002121 HRDC domain GO:0003676|GO:0005622 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 SMART SM00956 410 513 6.3E-11 T 21-04-2016 IPR018982 RQC domain GO:0006260|GO:0006281|GO:0043140 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 PANTHER PTHR13710:SF81 1 729 1.8E-240 T 21-04-2016 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Gene3D G3DSA:1.10.150.80 534 608 1.1E-19 T 21-04-2016 IPR002121 HRDC domain GO:0003676|GO:0005622 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 SUPERFAMILY SSF47819 531 613 1.4E-23 T 21-04-2016 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 SMART SM00490 248 329 5.9E-27 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Gene3D G3DSA:1.10.10.10 343 515 2.5E-44 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Pfam PF16124 RecQ zinc-binding 341 402 5.2E-14 T 21-04-2016 IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 TIGRFAM TIGR00614 recQ_fam: ATP-dependent DNA helicase, RecQ family 11 463 3.1E-154 T 21-04-2016 IPR004589 DNA helicase, ATP-dependent, RecQ type GO:0006310|GO:0008026 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Pfam PF09382 RQC domain 407 509 6.3E-18 T 21-04-2016 IPR018982 RQC domain GO:0006260|GO:0006281|GO:0043140 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 SMART SM00341 531 611 3.7E-17 T 21-04-2016 IPR002121 HRDC domain GO:0003676|GO:0005622 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Gene3D G3DSA:3.40.50.300 1 204 3.0E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 TIGRFAM TIGR01389 recQ: ATP-dependent DNA helicase RecQ 9 604 1.1E-203 T 21-04-2016 IPR006293 DNA helicase, ATP-dependent, RecQ type, bacterial GO:0004003|GO:0006310|GO:0009432 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 Gene3D G3DSA:3.40.50.300 205 342 4.8E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 PANTHER PTHR13710 1 729 1.8E-240 T 21-04-2016 SPH21_RS16755 896fb81cfb472f9942897e2b5109e4ee 729 SUPERFAMILY SSF46785 401 516 1.05E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23715 4d5b2ae97f3fcdfb251221d0e893f3ef 192 SUPERFAMILY SSF55729 1 176 5.75E-18 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23715 4d5b2ae97f3fcdfb251221d0e893f3ef 192 PANTHER PTHR21471:SF63 1 191 7.5E-26 T 21-04-2016 SPH21_RS23715 4d5b2ae97f3fcdfb251221d0e893f3ef 192 PANTHER PTHR21471 1 191 7.5E-26 T 21-04-2016 SPH21_RS23715 4d5b2ae97f3fcdfb251221d0e893f3ef 192 Pfam PF13673 Acetyltransferase (GNAT) domain 117 187 2.9E-10 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS23715 4d5b2ae97f3fcdfb251221d0e893f3ef 192 Gene3D G3DSA:3.40.630.30 1 186 4.2E-34 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS05085 305117594eed113da01b48e8465b6003 323 SUPERFAMILY SSF51735 3 148 3.24E-45 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05085 305117594eed113da01b48e8465b6003 323 SMART SM00859 5 125 3.5E-35 T 21-04-2016 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 TIGRFAM TIGR01850 argC: N-acetyl-gamma-glutamyl-phosphate reductase 4 319 3.2E-90 T 21-04-2016 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 ProSitePatterns PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 128 144 - T 21-04-2016 IPR023013 N-acetyl-gamma-glutamyl-phosphate reductase, active site GO:0003942|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 Gene3D G3DSA:3.40.50.720 1 141 9.0E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05085 305117594eed113da01b48e8465b6003 323 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 5 125 1.3E-28 T 21-04-2016 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 142 294 6.6E-5 T 21-04-2016 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 Hamap MF_00150 N-acetyl-gamma-glutamyl-phosphate reductase [argC]. 4 317 32.35 T 21-04-2016 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 PANTHER PTHR32338:SF8 2 323 1.1E-113 T 21-04-2016 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 SUPERFAMILY SSF55347 133 291 1.31E-34 T 21-04-2016 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 PANTHER PTHR32338 2 323 1.1E-113 T 21-04-2016 SPH21_RS05085 305117594eed113da01b48e8465b6003 323 Gene3D G3DSA:3.30.360.10 142 291 1.1E-41 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 PANTHER PTHR11731:SF117 13 62 8.2E-248 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 PANTHER PTHR11731:SF117 81 807 8.2E-248 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 PANTHER PTHR11731 13 62 8.2E-248 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 PANTHER PTHR11731 81 807 8.2E-248 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 Gene3D G3DSA:2.120.10.60 393 421 2.0E-10 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 Gene3D G3DSA:2.120.10.60 114 180 2.0E-10 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 Gene3D G3DSA:2.120.10.60 490 528 2.0E-10 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 Gene3D G3DSA:2.120.10.60 230 274 2.0E-10 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 SUPERFAMILY SSF53474 541 798 1.1E-45 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 Pfam PF00326 Prolyl oligopeptidase family 641 799 1.4E-22 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 SUPERFAMILY SSF82171 102 184 7.46E-13 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 SUPERFAMILY SSF82171 233 424 7.46E-13 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 SUPERFAMILY SSF82171 461 528 7.46E-13 T 21-04-2016 SPH21_RS08675 0a6a531b23e7c426068cb79c81c0707e 808 Gene3D G3DSA:3.40.50.1820 540 799 6.0E-49 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00995 65862a95853cce4b48f18f5901495d6a 542 PANTHER PTHR11559 438 533 1.7E-154 T 21-04-2016 SPH21_RS00995 65862a95853cce4b48f18f5901495d6a 542 PANTHER PTHR11559 3 413 1.7E-154 T 21-04-2016 SPH21_RS00995 65862a95853cce4b48f18f5901495d6a 542 SUPERFAMILY SSF53474 28 518 5.17E-118 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00995 65862a95853cce4b48f18f5901495d6a 542 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 203 218 - T 21-04-2016 IPR019826 Carboxylesterase type B, active site SPH21_RS00995 65862a95853cce4b48f18f5901495d6a 542 Pfam PF00135 Carboxylesterase family 27 526 5.9E-114 T 21-04-2016 IPR002018 Carboxylesterase, type B SPH21_RS00995 65862a95853cce4b48f18f5901495d6a 542 Gene3D G3DSA:3.40.50.1820 25 538 8.1E-144 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00995 65862a95853cce4b48f18f5901495d6a 542 ProSitePatterns PS00941 Carboxylesterases type-B signature 2. 103 113 - T 21-04-2016 IPR019819 Carboxylesterase type B, conserved site SPH21_RS20540 4d52bb134bfa64cde26b7c41d73898c9 202 PANTHER PTHR10587 19 199 5.2E-36 T 21-04-2016 SPH21_RS20540 4d52bb134bfa64cde26b7c41d73898c9 202 Pfam PF01522 Polysaccharide deacetylase 21 122 2.4E-24 T 21-04-2016 IPR002509 NodB homology domain GO:0005975|GO:0016810 SPH21_RS20540 4d52bb134bfa64cde26b7c41d73898c9 202 Gene3D G3DSA:3.20.20.370 16 200 6.9E-52 T 21-04-2016 IPR002509 NodB homology domain GO:0005975|GO:0016810 SPH21_RS20540 4d52bb134bfa64cde26b7c41d73898c9 202 SUPERFAMILY SSF88713 10 200 2.67E-51 T 21-04-2016 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SPH21_RS09245 ad6ba5f3ed7f27f7ec892bab81b6388d 371 PANTHER PTHR30273 166 371 1.3E-74 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09245 ad6ba5f3ed7f27f7ec892bab81b6388d 371 PANTHER PTHR30273 5 108 1.3E-74 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09245 ad6ba5f3ed7f27f7ec892bab81b6388d 371 Pfam PF16344 Domain of unknown function (DUF4974) 269 368 7.8E-26 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS09245 ad6ba5f3ed7f27f7ec892bab81b6388d 371 Pfam PF04773 FecR protein 164 258 5.1E-21 T 21-04-2016 IPR006860 FecR protein SPH21_RS09245 ad6ba5f3ed7f27f7ec892bab81b6388d 371 PANTHER PTHR30273:SF2 166 371 1.3E-74 T 21-04-2016 SPH21_RS09245 ad6ba5f3ed7f27f7ec892bab81b6388d 371 PANTHER PTHR30273:SF2 5 108 1.3E-74 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Gene3D G3DSA:2.40.170.20 367 446 1.5E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Gene3D G3DSA:2.40.170.20 241 260 1.5E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Gene3D G3DSA:2.40.170.20 922 947 1.5E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Gene3D G3DSA:2.40.170.20 484 868 1.5E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Gene3D G3DSA:2.40.170.20 992 1090 1.5E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Pfam PF13715 CarboxypepD_reg-like domain 45 126 2.0E-14 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Pfam PF07715 TonB-dependent Receptor Plug Domain 135 240 8.4E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Gene3D G3DSA:2.170.130.10 130 240 9.1E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 SUPERFAMILY SSF56935 367 436 1.24E-86 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 SUPERFAMILY SSF56935 996 1059 1.24E-86 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 SUPERFAMILY SSF56935 478 707 1.24E-86 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 SUPERFAMILY SSF56935 736 838 1.24E-86 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 SUPERFAMILY SSF56935 914 957 1.24E-86 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 SUPERFAMILY SSF56935 125 272 1.24E-86 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 217 246 9.6E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 PANTHER PTHR11532 561 1088 1.8E-267 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 PANTHER PTHR11532 20 338 1.8E-267 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 PANTHER PTHR11532 354 470 1.8E-267 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 SUPERFAMILY SSF49464 43 125 2.62E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 Gene3D G3DSA:2.60.40.1120 45 129 6.2E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 44 1090 5.2E-272 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 PANTHER PTHR11532:SF57 561 1088 1.8E-267 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 PANTHER PTHR11532:SF57 20 338 1.8E-267 T 21-04-2016 SPH21_RS14680 34d8798a9a9df2d62d8894445badccd0 1090 PANTHER PTHR11532:SF57 354 470 1.8E-267 T 21-04-2016 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 SUPERFAMILY SSF102114 99 304 1.7E-15 T 21-04-2016 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 SMART SM00729 103 318 0.0023 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 PIRSF PIRSF006004 3 351 8.2E-124 T 21-04-2016 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 Gene3D G3DSA:3.20.20.70 108 317 2.8E-16 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 Hamap MF_01849 Dual-specificity RNA methyltransferase RlmN [rlmN]. 4 347 67.886 T 21-04-2016 IPR027492 Dual-specificity RNA methyltransferase RlmN GO:0030488|GO:0070475 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 PANTHER PTHR30544 3 351 7.6E-145 T 21-04-2016 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 Pfam PF13394 4Fe-4S single cluster domain 112 225 1.1E-6 T 21-04-2016 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 TIGRFAM TIGR00048 rRNA_mod_RlmN: 23S rRNA (adenine(2503)-C(2))-methyltransferase 3 349 6.9E-118 T 21-04-2016 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 PANTHER PTHR30544:SF5 3 351 7.6E-145 T 21-04-2016 SPH21_RS05590 dda5ca61c8da9ee1534cb5df5d1cf2a7 351 Pfam PF04055 Radical SAM superfamily 108 278 1.4E-13 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 84 217 7.7E-18 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 PANTHER PTHR10066:SF72 75 881 2.9E-129 T 21-04-2016 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 SUPERFAMILY SSF49785 41 218 2.69E-33 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Gene3D G3DSA:2.70.98.10 773 888 3.0E-8 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 PRINTS PR00132 Glycosyl hydrolase family 2 signature 424 439 1.4E-5 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 PRINTS PR00132 Glycosyl hydrolase family 2 signature 332 346 1.4E-5 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 PANTHER PTHR10066 75 881 2.9E-129 T 21-04-2016 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 SUPERFAMILY SSF49303 220 320 1.53E-14 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 SUPERFAMILY SSF51445 326 573 8.21E-52 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Pfam PF02929 Beta galactosidase small chain 711 876 6.1E-7 T 21-04-2016 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Gene3D G3DSA:3.20.20.80 319 578 1.3E-52 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 327 535 4.2E-27 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Gene3D G3DSA:2.60.120.260 70 208 4.1E-33 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Gene3D G3DSA:2.60.40.320 589 655 0.001 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Gene3D G3DSA:2.60.40.320 209 318 5.8E-23 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 SUPERFAMILY SSF74650 697 883 1.19E-16 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS22240 1a39ac0245d9aa2ae3c58bc943f2462b 960 Pfam PF00703 Glycosyl hydrolases family 2 218 320 1.2E-14 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 Gene3D G3DSA:2.60.40.1120 32 117 7.1E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 SUPERFAMILY SSF56935 311 399 1.6E-85 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 SUPERFAMILY SSF56935 937 1009 1.6E-85 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 SUPERFAMILY SSF56935 853 896 1.6E-85 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 SUPERFAMILY SSF56935 109 251 1.6E-85 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 SUPERFAMILY SSF56935 433 787 1.6E-85 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 PANTHER PTHR11532:SF57 517 1027 5.2E-269 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 PANTHER PTHR11532:SF57 9 403 5.2E-269 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 Pfam PF07715 TonB-dependent Receptor Plug Domain 121 227 3.0E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 32 1029 2.7E-278 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 204 233 2.9E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 Gene3D G3DSA:2.170.130.10 118 230 7.0E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 PANTHER PTHR11532 517 1027 5.2E-269 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 PANTHER PTHR11532 9 403 5.2E-269 T 21-04-2016 SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 SUPERFAMILY SSF49464 31 111 1.31E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14225 4d348d3ea59f3b16c71bf44a0d6c439e 1029 Pfam PF13715 CarboxypepD_reg-like domain 33 113 5.4E-16 T 21-04-2016 SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 141 149 1.6E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 88 99 1.6E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 161 180 1.6E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 148 176 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 SUPERFAMILY SSF51735 7 254 7.88E-74 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PANTHER PTHR24322:SF513 161 193 2.3E-46 T 21-04-2016 SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PANTHER PTHR24322:SF513 16 145 2.3E-46 T 21-04-2016 SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 Gene3D G3DSA:3.40.50.720 4 254 2.3E-78 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 135 151 1.5E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 182 199 1.5E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 1.5E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 161 180 1.5E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 1.5E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 88 99 1.5E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 18 253 2.2E-55 T 21-04-2016 SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PANTHER PTHR24322 161 193 2.3E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03585 23fb4977e77c48a00dab90fbceb7618a 256 PANTHER PTHR24322 16 145 2.3E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08490 10b5cae5f492500acdb79c2823091f8d 220 Pfam PF09335 SNARE associated Golgi protein 49 175 2.9E-22 T 21-04-2016 IPR032816 SNARE associated Golgi protein SPH21_RS08490 10b5cae5f492500acdb79c2823091f8d 220 PANTHER PTHR30353 1 218 6.5E-89 T 21-04-2016 IPR032818 DedA family SPH21_RS08490 10b5cae5f492500acdb79c2823091f8d 220 PANTHER PTHR30353:SF0 1 218 6.5E-89 T 21-04-2016 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 Gene3D G3DSA:3.40.50.720 138 272 5.4E-54 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 Gene3D G3DSA:3.40.192.10 5 137 4.2E-47 T 21-04-2016 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 153 173 6.0E-78 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 247 263 6.0E-78 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 73 100 6.0E-78 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 32 54 6.0E-78 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 206 235 6.0E-78 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 264 282 6.0E-78 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 108 129 6.0E-78 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 PANTHER PTHR10025 2 289 3.6E-151 T 21-04-2016 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 Pfam PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 3 119 3.3E-39 T 21-04-2016 IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 SUPERFAMILY SSF51735 121 288 1.67E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 Pfam PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 122 290 1.0E-64 T 21-04-2016 IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 SUPERFAMILY SSF53223 1 120 2.3E-38 T 21-04-2016 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 ProSitePatterns PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 74 99 - T 21-04-2016 IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site GO:0003824|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS17180 f7eb8a0fca2c0d838b5ebc0cd790acee 294 Hamap MF_01576 Bifunctional protein FolD [folD]. 1 291 36.4 T 21-04-2016 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|UniPathway: UPA00193 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Gene3D G3DSA:2.60.40.1120 21 104 4.7E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 SUPERFAMILY SSF56935 940 1004 6.41E-84 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 SUPERFAMILY SSF56935 98 276 6.41E-84 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 SUPERFAMILY SSF56935 456 794 6.41E-84 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 SUPERFAMILY SSF56935 333 423 6.41E-84 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 SUPERFAMILY SSF56935 854 897 6.41E-84 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 SUPERFAMILY SSF49464 21 113 4.45E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Pfam PF13715 CarboxypepD_reg-like domain 21 102 3.3E-11 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Pfam PF07715 TonB-dependent Receptor Plug Domain 114 252 2.5E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 20 1022 1.9E-206 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Gene3D G3DSA:2.170.130.10 105 253 1.0E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 228 258 2.5E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 PANTHER PTHR11532 528 1020 9.4E-175 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 PANTHER PTHR11532 219 454 9.4E-175 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 PANTHER PTHR11532 3 191 9.4E-175 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Gene3D G3DSA:2.40.170.20 930 1019 6.6E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Gene3D G3DSA:2.40.170.20 342 815 6.6E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Gene3D G3DSA:2.40.170.20 862 887 6.6E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 Gene3D G3DSA:2.40.170.20 254 281 6.6E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 PANTHER PTHR11532:SF57 528 1020 9.4E-175 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 PANTHER PTHR11532:SF57 219 454 9.4E-175 T 21-04-2016 SPH21_RS00745 d751585c331ad4025ff01871f78c0fc4 1022 PANTHER PTHR11532:SF57 3 191 9.4E-175 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Gene3D G3DSA:2.40.170.20 461 823 7.1E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Gene3D G3DSA:2.40.170.20 348 426 7.1E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Gene3D G3DSA:2.40.170.20 954 1037 7.1E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Gene3D G3DSA:2.40.170.20 865 911 7.1E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Gene3D G3DSA:2.40.170.20 253 271 7.1E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 227 257 1.2E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Gene3D G3DSA:2.60.40.1120 35 129 5.9E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 SUPERFAMILY SSF49464 33 124 2.16E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Pfam PF13620 Carboxypeptidase regulatory-like domain 34 114 2.0E-16 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 PANTHER PTHR11532:SF57 14 393 1.7E-231 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 PANTHER PTHR11532:SF57 537 1035 1.7E-231 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 PANTHER PTHR11532:SF57 426 463 1.7E-231 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Pfam PF07715 TonB-dependent Receptor Plug Domain 135 251 4.0E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 PANTHER PTHR11532 14 393 1.7E-231 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 PANTHER PTHR11532 537 1035 1.7E-231 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 PANTHER PTHR11532 426 463 1.7E-231 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 34 1037 3.0E-252 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 Gene3D G3DSA:2.170.130.10 130 252 4.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 SUPERFAMILY SSF56935 944 1037 8.79E-101 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 SUPERFAMILY SSF56935 856 900 8.79E-101 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 SUPERFAMILY SSF56935 466 801 8.79E-101 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 SUPERFAMILY SSF56935 339 427 8.79E-101 T 21-04-2016 SPH21_RS08785 31a08fcdc84e637bb0b096821b0d484f 1037 SUPERFAMILY SSF56935 120 275 8.79E-101 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Pfam PF14450 Cell division protein FtsA 15 194 6.2E-10 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Pfam PF14450 Cell division protein FtsA 212 387 2.2E-22 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 TIGRFAM TIGR01174 ftsA: cell division protein FtsA 13 389 1.7E-111 T 21-04-2016 IPR020823 Cell division protein FtsA GO:0007049 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 SUPERFAMILY SSF53067 204 390 2.14E-40 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Gene3D G3DSA:3.30.1490.110 103 161 1.4E-15 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 PIRSF PIRSF003101 2 433 5.3E-135 T 21-04-2016 IPR020823 Cell division protein FtsA GO:0007049 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 PANTHER PTHR32432:SF4 2 408 7.0E-120 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 SMART SM00842 14 201 5.0E-81 T 21-04-2016 IPR003494 SHS2 domain inserted in FtsA GO:0005515|GO:0007049 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 SUPERFAMILY SSF53067 14 202 3.33E-49 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Gene3D G3DSA:3.30.420.40 162 214 1.4E-24 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Gene3D G3DSA:3.30.420.40 3 87 1.4E-24 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Pfam PF02491 SHS2 domain inserted in FTSA 89 166 3.9E-28 T 21-04-2016 IPR003494 SHS2 domain inserted in FtsA GO:0005515|GO:0007049 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 PANTHER PTHR32432 2 408 7.0E-120 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Hamap MF_02033 Cell division protein FtsA [ftsA]. 10 435 27.899 T 21-04-2016 IPR020823 Cell division protein FtsA GO:0007049 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Gene3D G3DSA:3.90.640.10 240 302 1.4E-15 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Gene3D G3DSA:3.30.420.40 215 239 1.2E-30 T 21-04-2016 SPH21_RS00260 2b73706d162ee4808927ab5ec0363b57 444 Gene3D G3DSA:3.30.420.40 303 357 1.2E-30 T 21-04-2016 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 ProSitePatterns PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 228 241 - T 21-04-2016 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 PANTHER PTHR11432:SF3 199 355 4.2E-125 T 21-04-2016 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 PANTHER PTHR11432:SF3 4 176 4.2E-125 T 21-04-2016 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 Pfam PF00146 NADH dehydrogenase 11 347 1.5E-110 T 21-04-2016 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 ProSitePatterns PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 49 64 - T 21-04-2016 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 PANTHER PTHR11432 4 176 4.2E-125 T 21-04-2016 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 PANTHER PTHR11432 199 355 4.2E-125 T 21-04-2016 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 SPH21_RS10855 dc6ac00c342e7143822c62eed8b808a7 358 Hamap MF_01350 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic [ndhA]. 3 355 23.61 T 21-04-2016 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 SMART SM00932 6 91 4.2E-33 T 21-04-2016 IPR014824 Scaffold protein Nfu/NifU, N-terminal SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 SUPERFAMILY SSF117916 101 181 1.87E-23 T 21-04-2016 SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 Gene3D G3DSA:3.30.1370.70 6 90 3.6E-25 T 21-04-2016 IPR014824 Scaffold protein Nfu/NifU, N-terminal SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 ProDom PD002830 NIFU NIFU NITROGEN-FIXING C-TERMINAL FIXATION NITROGEN NIFU-LIKE DOMAIN CLUSTER HESB/YADR/YFHF:NITROGEN-FIXING 122 181 2.0E-17 T 21-04-2016 IPR001075 NIF system FeS cluster assembly, NifU, C-terminal GO:0005506|GO:0016226|GO:0051536 SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 Pfam PF08712 Scaffold protein Nfu/NifU N terminal 6 90 1.5E-25 T 21-04-2016 IPR014824 Scaffold protein Nfu/NifU, N-terminal SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 PANTHER PTHR11178 8 180 7.2E-50 T 21-04-2016 SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 Pfam PF01106 NifU-like domain 114 180 3.4E-25 T 21-04-2016 IPR001075 NIF system FeS cluster assembly, NifU, C-terminal GO:0005506|GO:0016226|GO:0051536 SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 SUPERFAMILY SSF110836 6 86 1.09E-24 T 21-04-2016 IPR014824 Scaffold protein Nfu/NifU, N-terminal SPH21_RS18030 4dc9eb2bebe55e40e8eb0e6ff2a5106b 184 PIRSF PIRSF036773 1 183 2.9E-55 T 21-04-2016 SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 Pfam PF07715 TonB-dependent Receptor Plug Domain 134 236 1.3E-6 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 Gene3D G3DSA:2.170.130.10 147 233 2.0E-5 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 Pfam PF13715 CarboxypepD_reg-like domain 25 112 1.4E-13 T 21-04-2016 SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 SUPERFAMILY SSF56935 111 772 6.96E-46 T 21-04-2016 SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 SUPERFAMILY SSF49464 24 108 3.02E-11 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 PANTHER PTHR30069 1 569 3.6E-19 T 21-04-2016 SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 Gene3D G3DSA:2.40.170.20 234 761 2.2E-18 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22350 d74dbb0d756c4daf076a8fc5872de42b 787 Gene3D G3DSA:2.60.40.1120 25 104 2.1E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03760 154efa5bb5cbc2f7a042a8ca1fb9c952 357 PANTHER PTHR21600:SF3 27 290 2.6E-48 T 21-04-2016 SPH21_RS03760 154efa5bb5cbc2f7a042a8ca1fb9c952 357 Pfam PF04468 PSP1 C-terminal conserved region 93 177 3.6E-25 T 21-04-2016 IPR007557 PSP1, C-terminal SPH21_RS03760 154efa5bb5cbc2f7a042a8ca1fb9c952 357 PANTHER PTHR21600 27 290 2.6E-48 T 21-04-2016 SPH21_RS23170 fd204d630b2f1bc898313b2051117f39 585 SUPERFAMILY SSF48452 14 322 8.85E-125 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23170 fd204d630b2f1bc898313b2051117f39 585 SUPERFAMILY SSF48452 368 583 8.85E-125 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23170 fd204d630b2f1bc898313b2051117f39 585 Pfam PF07980 SusD family 259 583 7.1E-57 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23170 fd204d630b2f1bc898313b2051117f39 585 Pfam PF14322 Starch-binding associating with outer membrane 21 221 1.1E-20 T 21-04-2016 SPH21_RS23170 fd204d630b2f1bc898313b2051117f39 585 Gene3D G3DSA:1.25.40.10 422 516 2.7E-45 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23170 fd204d630b2f1bc898313b2051117f39 585 Gene3D G3DSA:1.25.40.10 202 302 2.7E-45 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 SUPERFAMILY SSF46689 184 234 7.7E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 SUPERFAMILY SSF51182 15 147 6.67E-10 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 PANTHER PTHR11019 16 292 1.1E-30 T 21-04-2016 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 SMART SM00342 200 284 6.6E-26 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 Gene3D G3DSA:1.10.10.60 237 284 7.2E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 SUPERFAMILY SSF46689 236 287 6.72E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 Pfam PF12833 Helix-turn-helix domain 206 284 1.4E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 Gene3D G3DSA:1.10.10.60 185 236 2.1E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 Gene3D G3DSA:2.60.120.10 15 76 3.4E-9 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 237 280 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 Pfam PF02311 AraC-like ligand binding domain 20 77 1.3E-4 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 268 284 8.0E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS04865 78d60ed188c17db6a62cc083a1107f6d 292 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 253 268 8.0E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 PANTHER PTHR31339:SF0 73 184 6.5E-77 T 21-04-2016 SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 PANTHER PTHR31339:SF0 207 451 6.5E-77 T 21-04-2016 SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 SMART SM00710 312 333 510.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 SMART SM00710 278 310 740.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 SMART SM00710 339 360 1000.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 SMART SM00710 252 277 10.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 Gene3D G3DSA:2.160.20.10 66 459 2.0E-80 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 Pfam PF00295 Glycosyl hydrolases family 28 227 369 1.0E-18 T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 SUPERFAMILY SSF51126 64 452 1.46E-68 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 PANTHER PTHR31339 73 184 6.5E-77 T 21-04-2016 SPH21_RS11435 287bd75b39ac58843dcab2a12bc8515d 528 PANTHER PTHR31339 207 451 6.5E-77 T 21-04-2016 SPH21_RS19415 b2c139fbcbfb6815007efbfe0d9e6d49 648 Pfam PF02705 K+ potassium transporter 16 537 2.3E-172 T 21-04-2016 IPR003855 Potassium transporter GO:0015079|GO:0016020|GO:0071805 SPH21_RS19415 b2c139fbcbfb6815007efbfe0d9e6d49 648 PANTHER PTHR30540:SF7 18 436 2.1E-146 T 21-04-2016 SPH21_RS19415 b2c139fbcbfb6815007efbfe0d9e6d49 648 PANTHER PTHR30540 18 436 2.1E-146 T 21-04-2016 SPH21_RS19415 b2c139fbcbfb6815007efbfe0d9e6d49 648 Hamap MF_01522 Low affinity potassium transport system protein kup [kup]. 7 633 26.041 T 21-04-2016 IPR023051 Potassium uptake protein, low affinity, Kup SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 ProSitePatterns PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 353 364 - T 21-04-2016 IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site GO:0008137|GO:0010181|GO:0051539|GO:0055114 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 SUPERFAMILY SSF140490 336 429 8.63E-37 T 21-04-2016 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 SUPERFAMILY SSF142019 5 238 1.44E-86 T 21-04-2016 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 Pfam PF10531 SLBB domain 244 292 1.6E-7 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 PANTHER PTHR11780:SF10 19 435 6.3E-211 T 21-04-2016 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 SMART SM00928 340 385 1.8E-24 T 21-04-2016 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 PANTHER PTHR11780 19 435 6.3E-211 T 21-04-2016 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 TIGRFAM TIGR01959 nuoF_fam: NADH oxidoreductase (quinone), F subunit 8 426 2.2E-179 T 21-04-2016 IPR011537 NADH ubiquinone oxidoreductase, F subunit GO:0010181|GO:0016651|GO:0051287|GO:0051539|GO:0055114 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 SUPERFAMILY SSF142984 239 335 1.1E-14 T 21-04-2016 SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 Pfam PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 46 215 1.8E-48 T 21-04-2016 IPR011538 NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain SPH21_RS07880 089fc7e7afa6421f209273dc7a3ec577 450 Pfam PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 343 425 8.7E-32 T 21-04-2016 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 TIGRFAM TIGR00613 reco: DNA repair protein RecO 4 151 1.3E-22 T 21-04-2016 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 PANTHER PTHR33991 1 240 1.9E-20 T 21-04-2016 SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 SUPERFAMILY SSF57863 84 224 4.71E-11 T 21-04-2016 SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 Hamap MF_00201 DNA repair protein RecO [recO]. 1 238 16.66 T 21-04-2016 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 SUPERFAMILY SSF50249 2 79 4.11E-10 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 Pfam PF02565 Recombination protein O C terminal 86 225 1.4E-13 T 21-04-2016 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 Pfam PF11967 Recombination protein O N terminal 3 76 2.4E-16 T 21-04-2016 IPR022572 DNA replication/recombination mediator RecO, N-terminal SPH21_RS00195 4b3f4f177c8ea317c4f0abe4c73a28d7 240 Gene3D G3DSA:2.40.50.140 2 83 2.2E-5 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 Hamap MF_00208 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [murE]. 2 482 33.084 T 21-04-2016 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 PANTHER PTHR23135 11 484 1.4E-177 T 21-04-2016 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 SUPERFAMILY SSF53623 101 325 3.53E-68 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 TIGRFAM TIGR01085 murE: UDP-N-acetylmuramyl-tripeptide synthetase 22 481 7.7E-150 T 21-04-2016 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 SUPERFAMILY SSF53244 328 484 6.67E-45 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 Gene3D G3DSA:3.90.190.20 332 475 1.9E-52 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 Pfam PF02875 Mur ligase family, glutamate ligase domain 327 413 5.0E-20 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 Pfam PF08245 Mur ligase middle domain 110 305 2.2E-46 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 Gene3D G3DSA:3.40.1390.10 6 100 3.9E-23 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 SUPERFAMILY SSF63418 3 101 9.81E-22 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 PANTHER PTHR23135:SF4 11 484 1.4E-177 T 21-04-2016 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 Pfam PF01225 Mur ligase family, catalytic domain 23 71 1.3E-9 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00295 64cacbd64c5a609074b69eae02ac310f 487 Gene3D G3DSA:3.40.1190.10 101 329 2.2E-67 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 Gene3D G3DSA:3.40.50.720 2 258 7.0E-64 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 257 3.2E-40 T 21-04-2016 SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PANTHER PTHR24319 1 258 1.1E-57 T 21-04-2016 SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PANTHER PTHR24319:SF23 1 258 1.1E-57 T 21-04-2016 SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 SUPERFAMILY SSF51735 6 258 2.22E-61 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 4.3E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 4.3E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 4.3E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 221 241 4.3E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 4.3E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS13405 2d6330a274af0e1869c385f091dfb9c8 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 4.3E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 PANTHER PTHR22648:SF0 2 411 8.7E-120 T 21-04-2016 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 Gene3D G3DSA:2.40.50.140 132 201 3.5E-19 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 SMART SM00316 136 203 3.0E-5 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 Hamap MF_00945_B Transcription termination/antitermination protein NusA [nusA]. 3 410 27.993 T 21-04-2016 IPR030842 Transcription termination/antitermination protein NusA, bacterial GO:0006353|GO:0031564 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 SUPERFAMILY SSF54814 203 280 2.35E-29 T 21-04-2016 IPR009019 K homology domain, prokaryotic type GO:0003723 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 Gene3D G3DSA:3.30.1480.10 3 127 7.7E-32 T 21-04-2016 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 Gene3D G3DSA:3.30.300.20 202 280 3.9E-35 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 Pfam PF13184 NusA-like KH domain 233 300 3.1E-26 T 21-04-2016 IPR025249 KH domain, NusA-like GO:0003723 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 SUPERFAMILY SSF69705 3 128 1.44E-31 T 21-04-2016 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 Gene3D G3DSA:3.30.300.20 282 349 3.7E-23 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 PANTHER PTHR22648 2 411 8.7E-120 T 21-04-2016 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 SUPERFAMILY SSF54814 284 346 3.6E-12 T 21-04-2016 IPR009019 K homology domain, prokaryotic type GO:0003723 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 TIGRFAM TIGR01953 NusA: transcription termination factor NusA 6 345 3.3E-118 T 21-04-2016 IPR010213 Transcription termination factor NusA GO:0003723 SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 SUPERFAMILY SSF50249 134 202 3.98E-14 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07965 44ce8eea51c18df54d2ed2de36ade033 411 Pfam PF08529 NusA N-terminal domain 6 127 1.8E-28 T 21-04-2016 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 SPH21_RS22145 9debac1837eda43b5d22c7ebfcb7e4ce 146 SUPERFAMILY SSF50249 86 145 1.27E-9 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS22145 9debac1837eda43b5d22c7ebfcb7e4ce 146 Pfam PF00313 'Cold-shock' DNA-binding domain 87 145 2.9E-8 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS22145 9debac1837eda43b5d22c7ebfcb7e4ce 146 SMART SM00357 87 146 0.0014 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS22145 9debac1837eda43b5d22c7ebfcb7e4ce 146 Gene3D G3DSA:2.40.50.140 85 146 6.6E-14 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 SUPERFAMILY SSF53218 1 182 3.66E-38 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 Hamap MF_00226_B Putative competence-damage inducible protein [cinA]. 1 416 140.845 T 21-04-2016 IPR008135 Competence-induced protein CinA SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 Gene3D G3DSA:3.90.950.20 251 412 1.5E-55 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 PANTHER PTHR13939 1 416 1.2E-162 T 21-04-2016 SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 Pfam PF02464 Competence-damaged protein 259 407 1.5E-55 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 PIRSF PIRSF006728 1 415 1.7E-133 T 21-04-2016 IPR008135 Competence-induced protein CinA SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 Pfam PF00994 Probable molybdopterin binding domain 4 169 3.7E-34 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 SMART SM00852 4 171 2.6E-35 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 2 166 1.9E-30 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 Gene3D G3DSA:3.40.980.10 1 86 6.7E-36 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 Gene3D G3DSA:3.40.980.10 130 169 6.7E-36 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 SUPERFAMILY SSF142433 251 411 5.62E-52 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 TIGRFAM TIGR00199 PncC_domain: amidohydrolase, PncC family 265 406 8.2E-50 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 TIGRFAM TIGR00200 cinA_nterm: competence/damage-inducible protein CinA N-terminal domain 1 410 1.4E-104 T 21-04-2016 IPR008135 Competence-induced protein CinA SPH21_RS12580 3ae5ec1e5b0d53ca19daa882bb89a6bb 416 PANTHER PTHR13939:SF0 1 416 1.2E-162 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 212 241 2.5E-13 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 999 4.3E-205 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Gene3D G3DSA:2.170.130.10 108 236 4.5E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 PANTHER PTHR11532 1 433 5.4E-176 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 PANTHER PTHR11532 560 997 5.4E-176 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 PANTHER PTHR11532 505 533 5.4E-176 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Pfam PF07715 TonB-dependent Receptor Plug Domain 115 235 7.0E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Gene3D G3DSA:2.60.40.1120 26 107 3.6E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Pfam PF13715 CarboxypepD_reg-like domain 26 106 9.4E-17 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 SUPERFAMILY SSF49464 25 104 1.7E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Gene3D G3DSA:2.40.170.20 237 256 4.9E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Gene3D G3DSA:2.40.170.20 828 853 4.9E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Gene3D G3DSA:2.40.170.20 431 789 4.9E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Gene3D G3DSA:2.40.170.20 324 398 4.9E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 Gene3D G3DSA:2.40.170.20 899 999 4.9E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 PANTHER PTHR11532:SF51 1 433 5.4E-176 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 PANTHER PTHR11532:SF51 560 997 5.4E-176 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 PANTHER PTHR11532:SF51 505 533 5.4E-176 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 SUPERFAMILY SSF56935 436 771 1.58E-88 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 SUPERFAMILY SSF56935 315 403 1.58E-88 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 SUPERFAMILY SSF56935 103 260 1.58E-88 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 SUPERFAMILY SSF56935 905 999 1.58E-88 T 21-04-2016 SPH21_RS04895 ed738b79a0bab24bea9403296a1230e8 999 SUPERFAMILY SSF56935 820 863 1.58E-88 T 21-04-2016 SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 PANTHER PTHR30627 3 620 5.3E-157 T 21-04-2016 SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 PANTHER PTHR30627:SF2 3 620 5.3E-157 T 21-04-2016 SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 Gene3D G3DSA:3.90.1310.10 118 216 4.2E-26 T 21-04-2016 SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 Gene3D G3DSA:3.40.710.10 236 585 6.2E-92 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 TIGRFAM TIGR03423 pbp2_mrdA: penicillin-binding protein 2 8 584 9.2E-154 T 21-04-2016 IPR017790 Penicillin-binding protein 2 GO:0016020 UniPathway: UPA00219 SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 Pfam PF00905 Penicillin binding protein transpeptidase domain 254 576 8.9E-59 T 21-04-2016 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 SUPERFAMILY SSF56519 43 234 1.7E-41 T 21-04-2016 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 SUPERFAMILY SSF56601 237 585 2.91E-83 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS11730 96b181a9cab1cf05d8ba0bc4a7e963f6 657 Pfam PF03717 Penicillin-binding Protein dimerisation domain 51 214 1.4E-37 T 21-04-2016 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SPH21_RS13600 b1ee5137e64c6d3c97ddcba1146a9897 331 Pfam PF08279 HTH domain 13 63 1.9E-15 T 21-04-2016 IPR013196 Helix-turn-helix, type 11 SPH21_RS13600 b1ee5137e64c6d3c97ddcba1146a9897 331 PANTHER PTHR34580 1 325 3.0E-48 T 21-04-2016 SPH21_RS13600 b1ee5137e64c6d3c97ddcba1146a9897 331 PIRSF PIRSF016838 2 321 3.0E-24 T 21-04-2016 IPR028349 Protein PafC SPH21_RS13600 b1ee5137e64c6d3c97ddcba1146a9897 331 Gene3D G3DSA:1.10.10.10 10 68 3.1E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13600 b1ee5137e64c6d3c97ddcba1146a9897 331 PANTHER PTHR34580:SF3 1 325 3.0E-48 T 21-04-2016 SPH21_RS13600 b1ee5137e64c6d3c97ddcba1146a9897 331 SUPERFAMILY SSF46785 9 66 2.33E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13600 b1ee5137e64c6d3c97ddcba1146a9897 331 Pfam PF13280 WYL domain 145 307 2.3E-25 T 21-04-2016 IPR026881 WYL domain SPH21_RS15130 7b03f7e3ff613dbce54a3f12eb5737b6 271 PANTHER PTHR10907:SF33 21 177 2.8E-37 T 21-04-2016 SPH21_RS15130 7b03f7e3ff613dbce54a3f12eb5737b6 271 PANTHER PTHR10907 21 177 2.8E-37 T 21-04-2016 SPH21_RS15130 7b03f7e3ff613dbce54a3f12eb5737b6 271 Pfam PF00756 Putative esterase 29 259 7.9E-37 T 21-04-2016 IPR000801 Putative esterase SPH21_RS15130 7b03f7e3ff613dbce54a3f12eb5737b6 271 SUPERFAMILY SSF53474 19 266 7.31E-51 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS15130 7b03f7e3ff613dbce54a3f12eb5737b6 271 Gene3D G3DSA:3.40.50.1820 19 265 5.4E-66 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 PANTHER PTHR11851 1 407 5.7E-110 T 21-04-2016 SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 Pfam PF00675 Insulinase (Peptidase family M16) 14 129 3.9E-18 T 21-04-2016 IPR011765 Peptidase M16, N-terminal SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 Gene3D G3DSA:3.30.830.10 236 404 4.3E-19 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 SUPERFAMILY SSF63411 229 407 3.5E-27 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 Pfam PF05193 Peptidase M16 inactive domain 170 344 4.5E-27 T 21-04-2016 IPR007863 Peptidase M16, C-terminal SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 SUPERFAMILY SSF63411 2 207 6.81E-52 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 Gene3D G3DSA:3.30.830.10 3 218 1.9E-53 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS18310 a0e2b870857e46d1896393d46dd8796f 411 PANTHER PTHR11851:SF136 1 407 5.7E-110 T 21-04-2016 SPH21_RS24620 2a2f838b6752f27472f040e544768d2e 225 Gene3D G3DSA:3.40.50.300 4 208 1.0E-33 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24620 2a2f838b6752f27472f040e544768d2e 225 PANTHER PTHR24220:SF497 6 215 1.8E-40 T 21-04-2016 SPH21_RS24620 2a2f838b6752f27472f040e544768d2e 225 Pfam PF00005 ABC transporter 23 153 8.7E-19 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS24620 2a2f838b6752f27472f040e544768d2e 225 SUPERFAMILY SSF52540 5 206 8.27E-34 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24620 2a2f838b6752f27472f040e544768d2e 225 PANTHER PTHR24220 6 215 1.8E-40 T 21-04-2016 SPH21_RS24620 2a2f838b6752f27472f040e544768d2e 225 SMART SM00382 30 194 5.3E-5 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 PANTHER PTHR36999 1 743 0.0 T 21-04-2016 SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 SUPERFAMILY SSF53659 4 741 0.0 T 21-04-2016 SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 PIRSF PIRSF009407 1 742 0.0 T 21-04-2016 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 TIGRFAM TIGR00178 monomer_idh: isocitrate dehydrogenase, NADP-dependent 3 741 0.0 T 21-04-2016 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 Pfam PF03971 Monomeric isocitrate dehydrogenase 6 739 0.0 T 21-04-2016 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 Gene3D G3DSA:3.40.718.10 340 363 6.3E-37 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 Gene3D G3DSA:3.40.718.10 539 646 6.3E-37 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS01805 71174e30892b4b4bed1ebd265748ea7b 744 Gene3D G3DSA:3.40.718.10 147 288 6.3E-37 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS05275 f276100939b691ff38ebfb2b7bc1eb3a 268 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 37 259 7.3E-23 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS05275 f276100939b691ff38ebfb2b7bc1eb3a 268 PANTHER PTHR14859 33 266 1.9E-41 T 21-04-2016 IPR027317 PGAP2-interacting protein SPH21_RS05275 f276100939b691ff38ebfb2b7bc1eb3a 268 Gene3D G3DSA:3.60.10.10 25 266 6.0E-24 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS05275 f276100939b691ff38ebfb2b7bc1eb3a 268 SUPERFAMILY SSF56219 26 267 4.97E-39 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS01505 b304c41602413e6cc7e3fd7890b1bb21 347 Pfam PF02661 Fic/DOC family 108 216 6.4E-18 T 21-04-2016 IPR003812 Fido domain SPH21_RS01505 b304c41602413e6cc7e3fd7890b1bb21 347 SUPERFAMILY SSF140931 86 274 1.31E-35 T 21-04-2016 IPR003812 Fido domain SPH21_RS01505 b304c41602413e6cc7e3fd7890b1bb21 347 Gene3D G3DSA:1.10.10.10 269 336 2.6E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01505 b304c41602413e6cc7e3fd7890b1bb21 347 SUPERFAMILY SSF46785 250 336 3.38E-9 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01505 b304c41602413e6cc7e3fd7890b1bb21 347 Pfam PF01047 MarR family 287 335 1.0E-8 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS01505 b304c41602413e6cc7e3fd7890b1bb21 347 PANTHER PTHR13504 10 334 3.4E-37 T 21-04-2016 SPH21_RS01505 b304c41602413e6cc7e3fd7890b1bb21 347 Gene3D G3DSA:1.10.3290.10 20 268 4.3E-59 T 21-04-2016 IPR003812 Fido domain SPH21_RS04725 efb5c7b83d326addcb7c237a7d37ecc7 162 TIGRFAM TIGR00632 vsr: DNA mismatch endonuclease Vsr 24 136 2.6E-41 T 21-04-2016 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SPH21_RS04725 efb5c7b83d326addcb7c237a7d37ecc7 162 Gene3D G3DSA:3.40.960.10 39 153 3.0E-42 T 21-04-2016 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SPH21_RS04725 efb5c7b83d326addcb7c237a7d37ecc7 162 Pfam PF04480 Protein of unknown function (DUF559) 112 152 1.8E-6 T 21-04-2016 IPR007569 Domain of unknown function DUF559 SPH21_RS04725 efb5c7b83d326addcb7c237a7d37ecc7 162 SUPERFAMILY SSF52980 22 153 6.43E-44 T 21-04-2016 IPR011335 Restriction endonuclease type II-like SPH21_RS04725 efb5c7b83d326addcb7c237a7d37ecc7 162 Pfam PF03852 DNA mismatch endonuclease Vsr 22 93 5.9E-30 T 21-04-2016 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 PANTHER PTHR11908:SF22 475 721 3.2E-146 T 21-04-2016 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 PANTHER PTHR11908:SF22 34 455 3.2E-146 T 21-04-2016 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 SUPERFAMILY SSF56003 34 235 4.88E-38 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 PANTHER PTHR11908 475 721 3.2E-146 T 21-04-2016 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 PANTHER PTHR11908 34 455 3.2E-146 T 21-04-2016 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 PIRSF PIRSF036389 1 723 8.2E-187 T 21-04-2016 IPR012368 Oxidoreductase molybdopterin-binding subunit, IorB-related SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 SUPERFAMILY SSF56003 484 721 1.63E-91 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 SUPERFAMILY SSF56003 316 451 1.63E-91 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 SMART SM01008 203 285 1.1E-9 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 Gene3D G3DSA:3.30.365.10 43 169 1.7E-35 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 Gene3D G3DSA:3.30.365.10 373 548 3.5E-23 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 Gene3D G3DSA:3.90.1170.50 174 268 2.5E-20 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 586 670 6.6E-15 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 317 452 8.5E-9 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 38 169 7.9E-23 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS05845 917f33d66b67c39553ad73f597f07f3a 723 Gene3D G3DSA:3.30.365.10 549 721 9.0E-36 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 ProDom PD157043 RIBOSOMAL S15 RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 30S CHLOROPLAST S15 MITOCHONDRIAL TYPE 11 88 5.0E-22 T 21-04-2016 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 SUPERFAMILY SSF47060 2 89 6.18E-30 T 21-04-2016 IPR009068 S15/NS1, RNA-binding Reactome: REACT_71 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 Hamap MF_01343_B 30S ribosomal protein S15 [rpsO]. 3 89 19.695 T 21-04-2016 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 ProSitePatterns PS00362 Ribosomal protein S15 signature. 39 69 - T 21-04-2016 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 TIGRFAM TIGR00952 S15_bact: ribosomal protein uS15 5 88 6.9E-30 T 21-04-2016 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 Gene3D G3DSA:1.10.287.10 2 89 1.7E-34 T 21-04-2016 IPR009068 S15/NS1, RNA-binding Reactome: REACT_71 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 SMART SM01387 8 88 2.2E-41 T 21-04-2016 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 Pfam PF00312 Ribosomal protein S15 8 88 6.3E-30 T 21-04-2016 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15310 76e85a5d37a84e2d3d3899ebfc83efc3 92 PANTHER PTHR23321 1 91 8.6E-31 T 21-04-2016 SPH21_RS00570 367d0bcb36e2a60143cfe2487ff56b8b 311 Pfam PF01610 Transposase 40 305 2.7E-59 T 21-04-2016 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SPH21_RS00570 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498:SF1 36 307 2.6E-13 T 21-04-2016 SPH21_RS00570 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498 36 307 2.6E-13 T 21-04-2016 SPH21_RS01800 367d0bcb36e2a60143cfe2487ff56b8b 311 Pfam PF01610 Transposase 40 305 2.7E-59 T 21-04-2016 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SPH21_RS01800 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498:SF1 36 307 2.6E-13 T 21-04-2016 SPH21_RS01800 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498 36 307 2.6E-13 T 21-04-2016 SPH21_RS00160 367d0bcb36e2a60143cfe2487ff56b8b 311 Pfam PF01610 Transposase 40 305 2.7E-59 T 21-04-2016 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SPH21_RS00160 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498:SF1 36 307 2.6E-13 T 21-04-2016 SPH21_RS00160 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498 36 307 2.6E-13 T 21-04-2016 SPH21_RS01515 367d0bcb36e2a60143cfe2487ff56b8b 311 Pfam PF01610 Transposase 40 305 2.7E-59 T 21-04-2016 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SPH21_RS01515 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498:SF1 36 307 2.6E-13 T 21-04-2016 SPH21_RS01515 367d0bcb36e2a60143cfe2487ff56b8b 311 PANTHER PTHR33498 36 307 2.6E-13 T 21-04-2016 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 Gene3D G3DSA:1.10.10.10 133 232 1.2E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 Pfam PF00486 Transcriptional regulatory protein, C terminal 157 230 3.3E-20 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 Gene3D G3DSA:3.40.50.2300 2 123 2.1E-39 T 21-04-2016 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 SUPERFAMILY SSF46894 134 231 5.1E-23 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 SMART SM00448 5 116 1.7E-43 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 PANTHER PTHR26402:SF614 5 233 4.6E-78 T 21-04-2016 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 SUPERFAMILY SSF52172 3 130 9.11E-39 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 SMART SM00862 154 230 2.3E-19 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 Pfam PF00072 Response regulator receiver domain 7 116 6.9E-31 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS25565 827fb0084ad2cf54e160274174c27032 236 PANTHER PTHR26402 5 233 4.6E-78 T 21-04-2016 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Gene3D G3DSA:3.30.565.10 515 668 2.2E-44 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Gene3D G3DSA:3.30.450.20 148 267 5.1E-26 T 21-04-2016 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SUPERFAMILY SSF55785 29 138 8.72E-11 T 21-04-2016 IPR000014 PAS domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SMART SM00387 558 668 2.1E-32 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Gene3D G3DSA:3.30.450.40 271 443 2.3E-23 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SUPERFAMILY SSF55781 272 454 2.06E-21 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SUPERFAMILY SSF55874 504 666 3.01E-44 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Gene3D G3DSA:3.30.450.20 21 136 1.2E-10 T 21-04-2016 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 23 144 5.1E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 142 266 1.0E-31 T 21-04-2016 IPR000014 PAS domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SMART SM00091 15 87 97.0 T 21-04-2016 IPR000014 PAS domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SMART SM00091 146 212 5.3E-11 T 21-04-2016 IPR000014 PAS domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 PANTHER PTHR24423 20 277 2.9E-104 T 21-04-2016 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 PANTHER PTHR24423 447 666 2.9E-104 T 21-04-2016 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Pfam PF00512 His Kinase A (phospho-acceptor) domain 450 514 2.4E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 559 667 6.5E-24 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SMART SM00086 96 138 0.0075 T 21-04-2016 IPR001610 PAC motif SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SMART SM00086 218 260 0.02 T 21-04-2016 IPR001610 PAC motif SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SUPERFAMILY SSF47384 440 510 3.92E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Gene3D G3DSA:1.10.287.130 444 510 3.0E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Pfam PF00989 PAS fold 147 257 4.7E-19 T 21-04-2016 IPR013767 PAS fold GO:0006355 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SUPERFAMILY SSF55785 140 258 1.92E-23 T 21-04-2016 IPR000014 PAS domain SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SMART SM00065 289 444 1.0E-9 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Pfam PF13185 GAF domain 288 435 9.1E-14 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 PRINTS PR00344 Bacterial sensor protein C-terminal signature 595 609 5.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 PRINTS PR00344 Bacterial sensor protein C-terminal signature 613 623 5.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 PRINTS PR00344 Bacterial sensor protein C-terminal signature 628 646 5.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 PRINTS PR00344 Bacterial sensor protein C-terminal signature 652 665 5.7E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 SMART SM00388 449 514 1.2E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10775 bdcb00134a417e7bf9ae8f56a1d79105 670 Pfam PF13426 PAS domain 30 137 0.0027 T 21-04-2016 IPR000014 PAS domain SPH21_RS10560 f0c810a6745155b31558df366edb7b8c 137 Gene3D G3DSA:1.10.10.10 23 119 9.7E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10560 f0c810a6745155b31558df366edb7b8c 137 Pfam PF01638 HxlR-like helix-turn-helix 29 115 9.7E-18 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS10560 f0c810a6745155b31558df366edb7b8c 137 SUPERFAMILY SSF46785 24 121 1.68E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10560 f0c810a6745155b31558df366edb7b8c 137 PANTHER PTHR33204:SF8 9 129 1.4E-18 T 21-04-2016 SPH21_RS10560 f0c810a6745155b31558df366edb7b8c 137 PANTHER PTHR33204 9 129 1.4E-18 T 21-04-2016 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 PANTHER PTHR10192 4 395 1.6E-110 T 21-04-2016 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Pfam PF03453 MoeA N-terminal region (domain I and II) 5 165 2.9E-32 T 21-04-2016 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 SUPERFAMILY SSF53218 175 319 6.15E-37 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Gene3D G3DSA:2.40.340.10 327 392 3.0E-8 T 21-04-2016 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Gene3D G3DSA:3.90.105.10 140 159 1.0E-15 T 21-04-2016 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Gene3D G3DSA:3.90.105.10 25 46 1.0E-15 T 21-04-2016 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Pfam PF00994 Probable molybdopterin binding domain 178 315 4.5E-23 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 SMART SM00852 178 316 2.2E-33 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Gene3D G3DSA:3.40.980.10 160 324 3.7E-49 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Pfam PF03454 MoeA C-terminal region (domain IV) 328 394 6.9E-8 T 21-04-2016 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 Gene3D G3DSA:2.170.190.11 47 139 7.2E-23 T 21-04-2016 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 SUPERFAMILY SSF63882 3 172 2.09E-43 T 21-04-2016 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 SUPERFAMILY SSF63867 325 395 7.19E-11 T 21-04-2016 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18610 bd3ec93477ae35903f0e237eaa318df2 399 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 175 310 5.4E-29 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS02405 74162a54408fa8bbbd27979b6db81611 431 PANTHER PTHR40111 120 426 1.0E-48 T 21-04-2016 SPH21_RS02405 74162a54408fa8bbbd27979b6db81611 431 PANTHER PTHR40111:SF1 120 426 1.0E-48 T 21-04-2016 SPH21_RS02405 74162a54408fa8bbbd27979b6db81611 431 Gene3D G3DSA:3.40.50.1820 122 430 1.8E-71 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS02405 74162a54408fa8bbbd27979b6db81611 431 Pfam PF05448 Acetyl xylan esterase (AXE1) 130 426 6.0E-46 T 21-04-2016 IPR008391 Acetyl xylan esterase SPH21_RS02405 74162a54408fa8bbbd27979b6db81611 431 SUPERFAMILY SSF53474 136 430 6.8E-30 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS18120 41e715125c97e015a8d95007c03ef0f8 172 PANTHER PTHR10885 3 157 1.1E-52 T 21-04-2016 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: REACT_22258|UniPathway: UPA00059 SPH21_RS18120 41e715125c97e015a8d95007c03ef0f8 172 PIRSF PIRSF018427 1 172 1.0E-52 T 21-04-2016 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: REACT_22258|UniPathway: UPA00059 SPH21_RS18120 41e715125c97e015a8d95007c03ef0f8 172 SUPERFAMILY SSF55811 4 167 3.79E-46 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS18120 41e715125c97e015a8d95007c03ef0f8 172 Pfam PF00293 NUDIX domain 28 156 9.7E-19 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS18120 41e715125c97e015a8d95007c03ef0f8 172 Gene3D G3DSA:3.90.79.10 3 170 2.6E-54 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS18120 41e715125c97e015a8d95007c03ef0f8 172 TIGRFAM TIGR02150 IPP_isom_1: isopentenyl-diphosphate delta-isomerase 4 158 1.9E-38 T 21-04-2016 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: REACT_22258|UniPathway: UPA00059 SPH21_RS18120 41e715125c97e015a8d95007c03ef0f8 172 Hamap MF_00202 Isopentenyl-diphosphate Delta-isomerase [idi]. 2 172 32.544 T 21-04-2016 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: REACT_22258|UniPathway: UPA00059 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 Gene3D G3DSA:1.10.3730.10 159 261 8.1E-30 T 21-04-2016 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|UniPathway: UPA00098 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 TIGRFAM TIGR00112 proC: pyrroline-5-carboxylate reductase 4 261 9.9E-68 T 21-04-2016 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|UniPathway: UPA00098 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 PANTHER PTHR11645 4 261 4.9E-92 T 21-04-2016 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|UniPathway: UPA00098 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 PIRSF PIRSF000193 1 267 5.6E-66 T 21-04-2016 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|UniPathway: UPA00098 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 Pfam PF14748 Pyrroline-5-carboxylate reductase dimerisation 160 261 1.8E-28 T 21-04-2016 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|UniPathway: UPA00098 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 SUPERFAMILY SSF51735 3 158 8.14E-28 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 Hamap MF_01925 Pyrroline-5-carboxylate reductase [proC]. 2 264 21.482 T 21-04-2016 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|UniPathway: UPA00098 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 PANTHER PTHR11645:SF8 4 261 4.9E-92 T 21-04-2016 SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 3 97 3.8E-13 T 21-04-2016 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 Gene3D G3DSA:3.40.50.720 3 157 5.3E-40 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05110 07e758ff0892e4b4f61e0454d202e9ab 267 SUPERFAMILY SSF48179 159 264 2.55E-26 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS15670 d7b632321de9de04b883235261623670 455 Gene3D G3DSA:1.10.8.60 313 386 1.1E-20 T 21-04-2016 SPH21_RS15670 d7b632321de9de04b883235261623670 455 SUPERFAMILY SSF52540 141 382 1.54E-63 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15670 d7b632321de9de04b883235261623670 455 Pfam PF02954 Bacterial regulatory protein, Fis family 415 452 5.2E-12 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS15670 d7b632321de9de04b883235261623670 455 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 418 435 3.2E-10 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS15670 d7b632321de9de04b883235261623670 455 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 435 455 3.2E-10 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS15670 d7b632321de9de04b883235261623670 455 PANTHER PTHR32071 1 455 6.3E-180 T 21-04-2016 SPH21_RS15670 d7b632321de9de04b883235261623670 455 Pfam PF00072 Response regulator receiver domain 4 111 6.1E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15670 d7b632321de9de04b883235261623670 455 Gene3D G3DSA:3.40.50.2300 1 122 6.4E-32 T 21-04-2016 SPH21_RS15670 d7b632321de9de04b883235261623670 455 SMART SM00448 2 112 2.9E-28 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15670 d7b632321de9de04b883235261623670 455 SUPERFAMILY SSF46689 353 454 5.63E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS15670 d7b632321de9de04b883235261623670 455 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 164 177 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS15670 d7b632321de9de04b883235261623670 455 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 353 362 - T 21-04-2016 IPR025944 Sigma-54 interaction domain, conserved site SPH21_RS15670 d7b632321de9de04b883235261623670 455 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 226 241 - T 21-04-2016 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 SPH21_RS15670 d7b632321de9de04b883235261623670 455 SMART SM00382 160 303 9.0E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS15670 d7b632321de9de04b883235261623670 455 PANTHER PTHR32071:SF18 1 455 6.3E-180 T 21-04-2016 SPH21_RS15670 d7b632321de9de04b883235261623670 455 Pfam PF00158 Sigma-54 interaction domain 142 306 4.5E-64 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS15670 d7b632321de9de04b883235261623670 455 Gene3D G3DSA:1.10.10.60 394 454 5.1E-17 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS15670 d7b632321de9de04b883235261623670 455 Gene3D G3DSA:3.40.50.300 141 312 6.4E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15670 d7b632321de9de04b883235261623670 455 SUPERFAMILY SSF52172 1 183 8.25E-35 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 Pfam PF12833 Helix-turn-helix domain 197 275 5.7E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 Gene3D G3DSA:1.10.10.60 230 277 1.9E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 Gene3D G3DSA:2.60.120.280 29 102 3.8E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 SMART SM00342 191 274 2.2E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 PANTHER PTHR11019 26 276 2.1E-45 T 21-04-2016 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 SUPERFAMILY SSF46689 230 276 3.67E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 PANTHER PTHR11019:SF45 26 276 2.1E-45 T 21-04-2016 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 Pfam PF02311 AraC-like ligand binding domain 29 76 8.9E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20830 d89e00f06915d79e0878b55dbf5928de 279 SUPERFAMILY SSF51215 30 101 3.66E-8 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 SUPERFAMILY SSF56954 9 477 3.66E-89 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 PANTHER PTHR30203:SF3 42 478 2.3E-118 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 Gene3D G3DSA:2.20.200.10 136 152 1.8E-5 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 Gene3D G3DSA:2.20.200.10 325 361 1.8E-5 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 Gene3D G3DSA:1.20.1600.10 153 324 4.6E-96 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 Gene3D G3DSA:1.20.1600.10 363 477 4.6E-96 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 Gene3D G3DSA:1.20.1600.10 53 90 4.6E-96 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 Pfam PF02321 Outer membrane efflux protein 64 265 4.9E-20 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 Pfam PF02321 Outer membrane efflux protein 290 474 1.6E-20 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 PANTHER PTHR30203 42 478 2.3E-118 T 21-04-2016 SPH21_RS07340 12e1c0683866e42947ef0cbd28632971 478 TIGRFAM TIGR01845 outer_NodT: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family 10 476 2.5E-77 T 21-04-2016 IPR010131 RND efflux system, outer membrane lipoprotein, NodT GO:0005215|GO:0006810|GO:0008289|GO:0016020 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 PRINTS PR00421 Thioredoxin family signature 61 72 3.4E-9 T 21-04-2016 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 PRINTS PR00421 Thioredoxin family signature 21 30 3.4E-9 T 21-04-2016 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 PRINTS PR00421 Thioredoxin family signature 13 21 3.4E-9 T 21-04-2016 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 TIGRFAM TIGR01068 thioredoxin: thioredoxin 3 96 5.0E-34 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 PANTHER PTHR10438 2 95 2.0E-35 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 Gene3D G3DSA:3.40.30.10 3 96 2.0E-33 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 PIRSF PIRSF000077 1 97 7.7E-36 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 Pfam PF00085 Thioredoxin 2 95 1.8E-28 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 SUPERFAMILY SSF52833 2 95 6.41E-35 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17880 aaa8614700afac16f93c4024cbe2f71c 97 ProSitePatterns PS00194 Thioredoxin family active site. 14 32 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 PANTHER PTHR11019 35 282 1.3E-37 T 21-04-2016 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 SUPERFAMILY SSF46689 235 281 1.08E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 PANTHER PTHR11019:SF45 35 282 1.3E-37 T 21-04-2016 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 Pfam PF12833 Helix-turn-helix domain 202 280 7.2E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 Gene3D G3DSA:1.10.10.60 235 280 1.5E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 SMART SM00342 196 279 1.1E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 248 263 4.8E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23775 3ccbb6951be957fc951f443845d34f31 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 263 279 4.8E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS19155 dfda212f70a4bbec5b6b767b3d2e2bac 247 PANTHER PTHR34220 37 247 4.3E-15 T 21-04-2016 SPH21_RS19155 dfda212f70a4bbec5b6b767b3d2e2bac 247 Pfam PF06580 Histidine kinase 59 126 1.7E-12 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS17435 36248d1fc52e207cdbf3903c16b719af 189 Gene3D G3DSA:1.10.10.10 128 188 2.0E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17435 36248d1fc52e207cdbf3903c16b719af 189 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 171 7.3E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17435 36248d1fc52e207cdbf3903c16b719af 189 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 129 143 7.3E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17435 36248d1fc52e207cdbf3903c16b719af 189 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 143 159 7.3E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17435 36248d1fc52e207cdbf3903c16b719af 189 Pfam PF00196 Bacterial regulatory proteins, luxR family 129 178 7.2E-13 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17435 36248d1fc52e207cdbf3903c16b719af 189 SUPERFAMILY SSF46894 125 188 1.67E-14 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS17435 36248d1fc52e207cdbf3903c16b719af 189 SMART SM00421 126 183 6.6E-13 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 SUPERFAMILY SSF46785 31 113 1.25E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 Pfam PF01022 Bacterial regulatory protein, arsR family 44 89 2.1E-15 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 SMART SM00418 36 115 2.2E-24 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 71 86 3.4E-14 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 86 101 3.4E-14 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 58 69 3.4E-14 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 38 53 3.4E-14 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 PANTHER PTHR33154 21 126 8.7E-22 T 21-04-2016 SPH21_RS01075 4314de1e5ad5c35524f7968f87f6480d 126 Gene3D G3DSA:1.10.10.10 4 113 1.4E-27 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Pfam PF07715 TonB-dependent Receptor Plug Domain 132 236 2.3E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Gene3D G3DSA:2.170.130.10 126 236 6.0E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 SUPERFAMILY SSF56935 953 1038 2.75E-96 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 SUPERFAMILY SSF56935 872 916 2.75E-96 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 SUPERFAMILY SSF56935 454 802 2.75E-96 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 SUPERFAMILY SSF56935 119 260 2.75E-96 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 SUPERFAMILY SSF56935 310 400 2.75E-96 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 SUPERFAMILY SSF49464 41 121 6.54E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Gene3D G3DSA:2.40.170.20 963 1038 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Gene3D G3DSA:2.40.170.20 881 926 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Gene3D G3DSA:2.40.170.20 319 385 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Gene3D G3DSA:2.40.170.20 237 264 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Gene3D G3DSA:2.40.170.20 430 825 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Pfam PF13715 CarboxypepD_reg-like domain 43 123 3.4E-18 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 212 242 2.2E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 42 1038 5.3E-276 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 PANTHER PTHR11532 539 578 3.4E-264 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 PANTHER PTHR11532 597 1036 3.4E-264 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 PANTHER PTHR11532 34 406 3.4E-264 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 PANTHER PTHR11532:SF57 539 578 3.4E-264 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 PANTHER PTHR11532:SF57 597 1036 3.4E-264 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 PANTHER PTHR11532:SF57 34 406 3.4E-264 T 21-04-2016 SPH21_RS23655 af6ef13804a8ca1eb51bf8115d6e5018 1038 Gene3D G3DSA:2.60.40.1120 42 125 6.3E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS07705 5d1900c6ee3e0e3bc9610da1acb58c7d 289 Hamap MF_00154 Protoheme IX farnesyltransferase [cyoE]. 4 287 15.672 T 21-04-2016 IPR006369 Protohaem IX farnesyltransferase GO:0008495|GO:0016021|GO:0048034 UniPathway: UPA00834 SPH21_RS07705 5d1900c6ee3e0e3bc9610da1acb58c7d 289 PANTHER PTHR11048:SF3 1 285 2.9E-74 T 21-04-2016 SPH21_RS07705 5d1900c6ee3e0e3bc9610da1acb58c7d 289 TIGRFAM TIGR01473 cyoE_ctaB: protoheme IX farnesyltransferase 8 283 5.2E-74 T 21-04-2016 IPR006369 Protohaem IX farnesyltransferase GO:0008495|GO:0016021|GO:0048034 UniPathway: UPA00834 SPH21_RS07705 5d1900c6ee3e0e3bc9610da1acb58c7d 289 PANTHER PTHR11048 1 285 2.9E-74 T 21-04-2016 SPH21_RS07705 5d1900c6ee3e0e3bc9610da1acb58c7d 289 ProSitePatterns PS00943 UbiA prenyltransferase family signature. 61 83 - T 21-04-2016 IPR030470 UbiA prenyltransferase conserved site SPH21_RS07705 5d1900c6ee3e0e3bc9610da1acb58c7d 289 Pfam PF01040 UbiA prenyltransferase family 30 272 8.8E-53 T 21-04-2016 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SPH21_RS05640 b383b81487e5a87589af871e8f6b3d7a 192 Gene3D G3DSA:3.90.1720.10 54 173 2.2E-37 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS05640 b383b81487e5a87589af871e8f6b3d7a 192 SUPERFAMILY SSF54001 50 173 8.83E-35 T 21-04-2016 SPH21_RS05640 b383b81487e5a87589af871e8f6b3d7a 192 Pfam PF00877 NlpC/P60 family 67 169 4.5E-25 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS05640 b383b81487e5a87589af871e8f6b3d7a 192 PANTHER PTHR21666 65 172 2.6E-24 T 21-04-2016 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 SUPERFAMILY SSF50104 126 271 1.14E-58 T 21-04-2016 IPR008991 Translation protein SH3-like domain SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 Gene3D G3DSA:4.10.950.10 196 273 1.5E-32 T 21-04-2016 IPR014726 Ribosomal protein L2, domain 3 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 Gene3D G3DSA:2.40.50.140 1 114 3.1E-51 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 SUPERFAMILY SSF50249 2 122 5.14E-48 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 SMART SM01382 124 251 7.8E-85 T 21-04-2016 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 SMART SM01383 42 118 7.6E-46 T 21-04-2016 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 Pfam PF00181 Ribosomal Proteins L2, RNA binding domain 42 117 4.9E-33 T 21-04-2016 IPR022666 Ribosomal Proteins L2, RNA binding domain GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 Hamap MF_01320_B 50S ribosomal protein L2 [rplB]. 1 273 46.019 T 21-04-2016 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 PANTHER PTHR13691 1 274 1.0E-135 T 21-04-2016 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 TIGRFAM TIGR01171 rplB_bact: ribosomal protein uL2 3 274 4.5E-123 T 21-04-2016 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 ProSitePatterns PS00467 Ribosomal protein L2 signature. 218 229 - T 21-04-2016 IPR022671 Ribosomal protein L2, conserved site GO:0003735|GO:0005840|GO:0006412 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 Gene3D G3DSA:2.30.30.30 119 195 2.5E-33 T 21-04-2016 IPR014722 Ribosomal protein L2 domain 2 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 PIRSF PIRSF002158 6 274 3.8E-98 T 21-04-2016 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08510 83f07c197f3d75b66d76bdd240e0fa84 274 Pfam PF03947 Ribosomal Proteins L2, C-terminal domain 126 249 5.3E-55 T 21-04-2016 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PANTHER PTHR24322 11 138 3.1E-60 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PANTHER PTHR24322 155 187 3.1E-60 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 142 170 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 Gene3D G3DSA:3.40.50.720 1 245 6.7E-82 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 SUPERFAMILY SSF51735 5 245 4.63E-81 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 7.7E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 208 228 7.7E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 7.7E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 7.7E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 7.7E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 7.7E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 165 0.0068 T 21-04-2016 SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 245 3.3E-62 T 21-04-2016 SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 4.1E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 4.1E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11675 ade467579f468c3efcc0f19c17dd4b43 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 4.1E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 TIGRFAM TIGR01484 HAD-SF-IIB: HAD hydrolase, family IIB 493 691 2.9E-19 T 21-04-2016 IPR006379 HAD-superfamily hydrolase, subfamily IIB Reactome: REACT_17015 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 TIGRFAM TIGR00685 T6PP: trehalose-phosphatase 489 723 1.0E-42 T 21-04-2016 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 Gene3D G3DSA:3.40.50.2000 248 444 1.2E-76 T 21-04-2016 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 Gene3D G3DSA:3.40.50.2000 3 247 2.7E-88 T 21-04-2016 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 PANTHER PTHR10788 5 725 4.5E-269 T 21-04-2016 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 PANTHER PTHR10788:SF6 5 725 4.5E-269 T 21-04-2016 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 SUPERFAMILY SSF53756 3 462 4.02E-151 T 21-04-2016 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 SUPERFAMILY SSF56784 492 723 1.86E-39 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 Pfam PF00982 Glycosyltransferase family 20 3 460 7.4E-152 T 21-04-2016 IPR001830 Glycosyl transferase, family 20 GO:0003824|GO:0005992 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 Pfam PF02358 Trehalose-phosphatase 495 710 1.1E-48 T 21-04-2016 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 Gene3D G3DSA:3.40.50.1000 492 567 1.7E-38 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS06515 82fb4f3718358e54678585b6fcd947c4 725 Gene3D G3DSA:3.40.50.1000 647 724 1.7E-38 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 SMART SM00847 393 490 8.6E-10 T 21-04-2016 IPR007502 Helicase-associated domain GO:0004386 SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 Gene3D G3DSA:3.40.50.300 9 167 1.4E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 SUPERFAMILY SSF52540 22 344 9.13E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 Pfam PF00271 Helicase conserved C-terminal domain 211 333 8.0E-13 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 Gene3D G3DSA:3.40.50.300 209 353 3.0E-15 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 Pfam PF00270 DEAD/DEAH box helicase 23 171 7.2E-8 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 Pfam PF08482 ATP-dependent helicase C-terminal 682 815 2.5E-49 T 21-04-2016 IPR013689 ATP-dependent RNA helicase HrpB, C-terminal SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 SMART SM00490 232 333 2.9E-13 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 TIGRFAM TIGR01970 DEAH_box_HrpB: ATP-dependent helicase HrpB 10 825 1.3E-273 T 21-04-2016 IPR010225 RNA helicase, ATP-dependent DEAH box, HrpB-type SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 Pfam PF04408 Helicase associated domain (HA2) 394 469 3.3E-10 T 21-04-2016 IPR007502 Helicase-associated domain GO:0004386 SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 SMART SM00487 4 192 9.5E-19 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 PIRSF PIRSF005496 5 829 7.5E-283 T 21-04-2016 IPR010225 RNA helicase, ATP-dependent DEAH box, HrpB-type SPH21_RS09870 bdfd76f7dbef53e5030427d550cec520 830 PANTHER PTHR18934 9 429 5.5E-131 T 21-04-2016 SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 145 7.9E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 7.9E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 84 95 7.9E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 6.9E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 6.9E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 6.9E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 6.9E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 6.9E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 SUPERFAMILY SSF51735 6 229 2.21E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10710 a91771a48430410708f947dad311bae8 266 Gene3D G3DSA:3.40.50.720 7 247 7.0E-56 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PANTHER PTHR24322 157 188 2.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PANTHER PTHR24322 13 141 2.1E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 Pfam PF00106 short chain dehydrogenase 10 199 1.1E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10710 a91771a48430410708f947dad311bae8 266 PIRSF PIRSF000126 1 264 2.6E-66 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS06595 0328b5d0e376aa59218bd0fc4d232ced 194 TIGRFAM TIGR03512 GldD_lipo: gliding motility-associated lipoprotein GldD 7 193 1.0E-56 T 21-04-2016 IPR019850 Gliding motility-associated lipoprotein, GldD SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 PANTHER PTHR32120:SF2 1 297 1.5E-110 T 21-04-2016 SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 SUPERFAMILY SSF52540 79 300 3.09E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 SUPERFAMILY SSF50249 1 67 2.86E-11 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 Pfam PF16745 RsgA N-terminal domain 2 57 3.6E-18 T 21-04-2016 IPR031944 Ribosome biogenesis GTPase RsgA, N-terminal SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 Gene3D G3DSA:2.40.50.140 1 63 2.1E-18 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 Gene3D G3DSA:1.10.40.50 242 300 5.7E-24 T 21-04-2016 SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 Gene3D G3DSA:3.40.50.300 77 239 3.7E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 TIGRFAM TIGR00157 TIGR00157: ribosome small subunit-dependent GTPase A 43 297 4.8E-67 T 21-04-2016 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 Pfam PF03193 Protein of unknown function, DUF258 64 240 2.1E-51 T 21-04-2016 IPR010914 RsgA type GTPase domain GO:0003924|GO:0005525 SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 Hamap MF_01820 Putative ribosome biogenesis GTPase RsgA [rsgA]. 1 305 35.437 T 21-04-2016 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SPH21_RS07065 905a8b96dc3649655de72ce565b52bc5 305 PANTHER PTHR32120 1 297 1.5E-110 T 21-04-2016 SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 47 63 5.6E-8 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 33 47 5.6E-8 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 Pfam PF00392 Bacterial regulatory proteins, gntR family 10 73 2.2E-19 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 Pfam PF07729 FCD domain 97 211 1.0E-18 T 21-04-2016 IPR011711 GntR, C-terminal SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 SMART SM00345 14 73 1.2E-16 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 PANTHER PTHR11751 12 110 2.8E-25 T 21-04-2016 SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 SUPERFAMILY SSF46785 3 83 1.15E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 Gene3D G3DSA:1.20.120.530 89 214 7.7E-23 T 21-04-2016 IPR008920 Transcription regulator FadR/GntR, C-terminal SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 Gene3D G3DSA:1.10.10.10 6 78 6.5E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 SUPERFAMILY SSF48008 91 218 8.63E-23 T 21-04-2016 IPR008920 Transcription regulator FadR/GntR, C-terminal SPH21_RS19125 f66173551666bf17b6629f0ae6f8460f 221 SMART SM00895 94 218 1.1E-12 T 21-04-2016 IPR011711 GntR, C-terminal SPH21_RS14320 7934846d1ae51edf5a5e22b7090aee4c 244 Gene3D G3DSA:3.40.50.1110 26 243 8.5E-78 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS14320 7934846d1ae51edf5a5e22b7090aee4c 244 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 30 221 1.4E-14 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS14320 7934846d1ae51edf5a5e22b7090aee4c 244 PANTHER PTHR31321 140 227 4.4E-23 T 21-04-2016 SPH21_RS14320 7934846d1ae51edf5a5e22b7090aee4c 244 PANTHER PTHR31321:SF29 140 227 4.4E-23 T 21-04-2016 SPH21_RS14320 7934846d1ae51edf5a5e22b7090aee4c 244 SUPERFAMILY SSF52266 26 241 9.16E-52 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 ProSitePatterns PS00361 Ribosomal protein S10 signature. 28 43 - T 21-04-2016 IPR018268 Ribosomal protein S10, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 SMART SM01403 6 100 6.6E-53 T 21-04-2016 IPR027486 Ribosomal protein S10 domain SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 SUPERFAMILY SSF54999 4 101 2.22E-36 T 21-04-2016 IPR027486 Ribosomal protein S10 domain SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 Pfam PF00338 Ribosomal protein S10p/S20e 6 100 4.2E-35 T 21-04-2016 IPR027486 Ribosomal protein S10 domain SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 Hamap MF_00508 30S ribosomal protein S10 [rpsJ]. 2 101 25.246 T 21-04-2016 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 Gene3D G3DSA:3.30.70.600 3 101 1.9E-42 T 21-04-2016 IPR027486 Ribosomal protein S10 domain SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 PRINTS PR00971 Ribosomal protein S10 family signature 4 17 1.7E-16 T 21-04-2016 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 PRINTS PR00971 Ribosomal protein S10 family signature 60 74 1.7E-16 T 21-04-2016 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 PRINTS PR00971 Ribosomal protein S10 family signature 39 54 1.7E-16 T 21-04-2016 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 PANTHER PTHR11700 1 101 2.1E-46 T 21-04-2016 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 SPH21_RS19745 ee1047e772d722bb8668c6edd3a9ae21 101 TIGRFAM TIGR01049 rpsJ_bact: ribosomal protein uS10 3 101 5.5E-43 T 21-04-2016 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 PANTHER PTHR30069 478 638 1.2E-22 T 21-04-2016 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 Gene3D G3DSA:2.170.130.10 116 218 7.6E-8 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 PANTHER PTHR30069:SF1 24 458 1.2E-22 T 21-04-2016 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 SUPERFAMILY SSF56935 104 459 1.47E-67 T 21-04-2016 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 SUPERFAMILY SSF56935 488 771 1.47E-67 T 21-04-2016 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 Pfam PF07715 TonB-dependent Receptor Plug Domain 140 218 8.6E-10 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 Gene3D G3DSA:2.60.40.1120 24 99 6.5E-18 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 Pfam PF13715 CarboxypepD_reg-like domain 25 106 7.8E-17 T 21-04-2016 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 Gene3D G3DSA:2.40.170.20 245 738 1.1E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 SUPERFAMILY SSF49464 24 111 1.57E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 PANTHER PTHR30069:SF1 478 638 1.2E-22 T 21-04-2016 SPH21_RS20550 defa5f0fefbab56ff23724a8c4e4af7a 771 PANTHER PTHR30069 24 458 1.2E-22 T 21-04-2016 SPH21_RS06015 1e92e263da25ef5ae5b808b2fc4bd621 467 PANTHER PTHR11206 2 467 4.1E-98 T 21-04-2016 SPH21_RS06015 1e92e263da25ef5ae5b808b2fc4bd621 467 PANTHER PTHR11206:SF132 2 467 4.1E-98 T 21-04-2016 SPH21_RS06015 1e92e263da25ef5ae5b808b2fc4bd621 467 TIGRFAM TIGR00797 matE: MATE efflux family protein 40 437 2.8E-81 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS06015 1e92e263da25ef5ae5b808b2fc4bd621 467 PIRSF PIRSF006603 18 467 8.6E-125 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS06015 1e92e263da25ef5ae5b808b2fc4bd621 467 Pfam PF01554 MatE 40 200 2.4E-32 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS06015 1e92e263da25ef5ae5b808b2fc4bd621 467 Pfam PF01554 MatE 269 425 7.0E-31 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 PANTHER PTHR11532:SF57 622 648 9.9E-253 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 PANTHER PTHR11532:SF57 136 549 9.9E-253 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 PANTHER PTHR11532:SF57 676 1123 9.9E-253 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 PANTHER PTHR11532 622 648 9.9E-253 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 PANTHER PTHR11532 136 549 9.9E-253 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 PANTHER PTHR11532 676 1123 9.9E-253 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Gene3D G3DSA:2.60.40.1120 140 223 7.0E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 SUPERFAMILY SSF56935 950 994 9.42E-106 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 SUPERFAMILY SSF56935 214 372 9.42E-106 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 SUPERFAMILY SSF56935 431 519 9.42E-106 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 SUPERFAMILY SSF56935 1033 1125 9.42E-106 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 SUPERFAMILY SSF56935 552 883 9.42E-106 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Pfam PF07715 TonB-dependent Receptor Plug Domain 227 348 5.4E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Pfam PF13715 CarboxypepD_reg-like domain 140 220 2.2E-16 T 21-04-2016 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Gene3D G3DSA:2.40.170.20 923 924 1.1E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Gene3D G3DSA:2.40.170.20 349 381 1.1E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Gene3D G3DSA:2.40.170.20 959 984 1.1E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Gene3D G3DSA:2.40.170.20 440 883 1.1E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Gene3D G3DSA:2.40.170.20 1022 1125 1.1E-61 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Gene3D G3DSA:2.170.130.10 224 348 4.1E-25 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 Pfam PF00593 TonB dependent receptor 723 1123 2.5E-19 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 SUPERFAMILY SSF49464 139 218 6.28E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 139 1125 4.2E-273 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09330 722b55fb62d49a173054743d02e92500 1125 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 324 354 4.2E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS00315 b1062d63e0a76f68eb719304b81e196f 154 PANTHER PTHR34701 4 153 8.7E-39 T 21-04-2016 SPH21_RS00315 b1062d63e0a76f68eb719304b81e196f 154 Hamap MF_01008 Transcriptional regulator MraZ [mraZ]. 1 154 39.794 T 21-04-2016 IPR003444 Transcriptional regulator MraZ GO:0003700|GO:0006355 SPH21_RS00315 b1062d63e0a76f68eb719304b81e196f 154 TIGRFAM TIGR00242 TIGR00242: division/cell wall cluster transcriptional repressor MraZ 4 144 1.2E-35 T 21-04-2016 IPR003444 Transcriptional regulator MraZ GO:0003700|GO:0006355 SPH21_RS00315 b1062d63e0a76f68eb719304b81e196f 154 ProDom PD006745 MRAZ YABB DIVISION CELL 3D-STRUCTURE UNCHARACTERIZED BCR SIMILAR PROTEIN 4 144 2.0E-22 T 21-04-2016 IPR003444 Transcriptional regulator MraZ GO:0003700|GO:0006355 SPH21_RS00315 b1062d63e0a76f68eb719304b81e196f 154 SUPERFAMILY SSF89447 1 142 8.37E-39 T 21-04-2016 SPH21_RS00315 b1062d63e0a76f68eb719304b81e196f 154 Pfam PF02381 MraZ protein, putative antitoxin-like 4 76 1.7E-15 T 21-04-2016 IPR020603 MraZ domain SPH21_RS00315 b1062d63e0a76f68eb719304b81e196f 154 Pfam PF02381 MraZ protein, putative antitoxin-like 78 137 4.0E-12 T 21-04-2016 IPR020603 MraZ domain SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 Gene3D G3DSA:3.40.50.300 4 211 3.1E-68 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 Pfam PF03143 Elongation factor Tu C-terminal domain 299 393 3.2E-33 T 21-04-2016 IPR004160 Translation elongation factor EFTu/EF1A, C-terminal SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 51 66 - T 21-04-2016 IPR031157 Tr-type G domain, conserved site SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 PANTHER PTHR23115:SF112 1 394 4.6E-246 T 21-04-2016 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 Pfam PF03144 Elongation factor Tu domain 2 225 295 2.5E-16 T 21-04-2016 IPR004161 Translation elongation factor EFTu/EF1A, domain 2 GO:0005525 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 SUPERFAMILY SSF50447 207 302 2.75E-30 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 TIGRFAM TIGR00485 EF-Tu: translation elongation factor Tu 1 394 1.0E-222 T 21-04-2016 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 Gene3D G3DSA:2.40.30.10 301 394 1.9E-45 T 21-04-2016 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 Hamap MF_00118_B Elongation factor Tu [tuf]. 1 395 59.446 T 21-04-2016 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 PANTHER PTHR23115 1 394 4.6E-246 T 21-04-2016 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 SUPERFAMILY SSF50465 303 395 6.91E-36 T 21-04-2016 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 Gene3D G3DSA:2.40.30.10 212 299 1.6E-35 T 21-04-2016 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 Pfam PF00009 Elongation factor Tu GTP binding domain 10 201 1.8E-57 T 21-04-2016 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 SUPERFAMILY SSF52540 9 226 4.83E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 PRINTS PR00315 GTP-binding elongation factor signature 14 27 9.0E-25 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 PRINTS PR00315 GTP-binding elongation factor signature 78 88 9.0E-25 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 PRINTS PR00315 GTP-binding elongation factor signature 94 105 9.0E-25 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 PRINTS PR00315 GTP-binding elongation factor signature 131 140 9.0E-25 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 PRINTS PR00315 GTP-binding elongation factor signature 58 66 9.0E-25 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS11865 99527cffd00554865f9d7def3c387210 395 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 14 145 5.7E-14 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS24235 45494f91222cd8f525a4b57372ee1cb8 202 Gene3D G3DSA:2.60.120.10 12 146 3.7E-13 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS24235 45494f91222cd8f525a4b57372ee1cb8 202 Pfam PF00027 Cyclic nucleotide-binding domain 47 124 1.6E-6 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS24235 45494f91222cd8f525a4b57372ee1cb8 202 SUPERFAMILY SSF51206 12 151 5.89E-11 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 Gene3D G3DSA:3.40.50.1360 76 215 3.0E-15 T 21-04-2016 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 SUPERFAMILY SSF46785 5 63 4.88E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 Pfam PF08220 DeoR-like helix-turn-helix domain 6 60 1.3E-16 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 Pfam PF00455 DeoR C terminal sensor domain 75 233 1.3E-48 T 21-04-2016 IPR014036 DeoR C-terminal sensor domain SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 SUPERFAMILY SSF100950 75 235 1.86E-32 T 21-04-2016 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 6.2E-7 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 6.2E-7 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 21-04-2016 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 SMART SM01134 73 234 1.4E-63 T 21-04-2016 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 SMART SM00420 6 58 3.7E-15 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 PANTHER PTHR30363:SF1 1 254 4.7E-79 T 21-04-2016 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 PANTHER PTHR30363 1 254 4.7E-79 T 21-04-2016 SPH21_RS14475 8cf5b150867b1a80ecb1e7928525202b 254 Gene3D G3DSA:1.10.10.10 5 75 1.2E-9 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16370 7cc86d924332177e9b96caa6e96a9681 105 PANTHER PTHR30561:SF0 1 105 5.0E-46 T 21-04-2016 SPH21_RS16370 7cc86d924332177e9b96caa6e96a9681 105 Pfam PF00893 Small Multidrug Resistance protein 1 92 1.4E-26 T 21-04-2016 IPR000390 Small multidrug resistance protein family GO:0016021 SPH21_RS16370 7cc86d924332177e9b96caa6e96a9681 105 SUPERFAMILY SSF103481 4 102 1.83E-18 T 21-04-2016 SPH21_RS16370 7cc86d924332177e9b96caa6e96a9681 105 PANTHER PTHR30561 1 105 5.0E-46 T 21-04-2016 SPH21_RS11390 912d7e563395c52bd8be0f1e36b5a836 464 Gene3D G3DSA:3.20.20.80 33 322 5.9E-15 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11390 912d7e563395c52bd8be0f1e36b5a836 464 Pfam PF13204 Protein of unknown function (DUF4038) 34 368 1.3E-110 T 21-04-2016 IPR025277 Putative glycohydrolase domain DUF4038 SPH21_RS11390 912d7e563395c52bd8be0f1e36b5a836 464 SUPERFAMILY SSF51445 33 289 2.66E-15 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS11390 912d7e563395c52bd8be0f1e36b5a836 464 Pfam PF12904 Putative collagen-binding domain of a collagenase 372 462 2.1E-32 T 21-04-2016 IPR024749 Putative collagen-binding domain SPH21_RS11390 912d7e563395c52bd8be0f1e36b5a836 464 PANTHER PTHR37836 33 449 1.0E-102 T 21-04-2016 SPH21_RS11390 912d7e563395c52bd8be0f1e36b5a836 464 PANTHER PTHR37836:SF2 33 449 1.0E-102 T 21-04-2016 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 Gene3D G3DSA:1.10.10.60 185 241 2.2E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 SMART SM00342 205 288 5.3E-27 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 Pfam PF12833 Helix-turn-helix domain 211 290 2.8E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 SUPERFAMILY SSF51215 29 163 5.89E-21 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 SUPERFAMILY SSF46689 242 291 3.32E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 PANTHER PTHR11019 47 296 1.2E-38 T 21-04-2016 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 SUPERFAMILY SSF46689 190 238 3.45E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 Gene3D G3DSA:2.60.120.280 19 163 2.6E-25 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 PANTHER PTHR11019:SF65 47 296 1.2E-38 T 21-04-2016 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 Gene3D G3DSA:1.10.10.60 242 291 7.4E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 242 284 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS20605 d173f006116f9945e12d52da6ad4e680 296 Pfam PF02311 AraC-like ligand binding domain 51 150 8.0E-11 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Gene3D G3DSA:2.170.130.10 127 236 2.9E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532 487 534 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532 789 986 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532 550 771 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532 1 413 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532:SF57 487 534 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532:SF57 789 986 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532:SF57 550 771 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 PANTHER PTHR11532:SF57 1 413 6.5E-208 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Gene3D G3DSA:2.40.170.20 237 257 6.3E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Gene3D G3DSA:2.40.170.20 840 988 6.3E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Gene3D G3DSA:2.40.170.20 308 773 6.3E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 SUPERFAMILY SSF49464 31 130 4.12E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Pfam PF00593 TonB dependent receptor 595 987 2.5E-22 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Pfam PF13620 Carboxypeptidase regulatory-like domain 31 112 1.5E-14 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 213 243 3.5E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 31 988 2.6E-211 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Pfam PF07715 TonB-dependent Receptor Plug Domain 131 237 7.8E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 Gene3D G3DSA:2.60.40.1120 30 126 4.4E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 SUPERFAMILY SSF56935 120 261 2.31E-98 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 SUPERFAMILY SSF56935 903 988 2.31E-98 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 SUPERFAMILY SSF56935 299 388 2.31E-98 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 SUPERFAMILY SSF56935 831 875 2.31E-98 T 21-04-2016 SPH21_RS00955 d9a297515be067600fb3b63ad7f10c7e 988 SUPERFAMILY SSF56935 416 761 2.31E-98 T 21-04-2016 SPH21_RS16045 4b91a5056a4ee6a9511ee6c6312c41bd 438 TIGRFAM TIGR00836 amt: ammonium transporter 39 432 4.6E-110 T 21-04-2016 IPR001905 Ammonium transporter GO:0008519|GO:0016020|GO:0072488 SPH21_RS16045 4b91a5056a4ee6a9511ee6c6312c41bd 438 PANTHER PTHR11730:SF6 18 432 3.9E-139 T 21-04-2016 SPH21_RS16045 4b91a5056a4ee6a9511ee6c6312c41bd 438 Pfam PF00909 Ammonium Transporter Family 41 432 1.4E-108 T 21-04-2016 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 SPH21_RS16045 4b91a5056a4ee6a9511ee6c6312c41bd 438 SUPERFAMILY SSF111352 37 413 6.41E-105 T 21-04-2016 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 SPH21_RS16045 4b91a5056a4ee6a9511ee6c6312c41bd 438 PANTHER PTHR11730 18 432 3.9E-139 T 21-04-2016 IPR001905 Ammonium transporter GO:0008519|GO:0016020|GO:0072488 SPH21_RS16045 4b91a5056a4ee6a9511ee6c6312c41bd 438 Gene3D G3DSA:1.10.3430.10 37 413 2.1E-109 T 21-04-2016 IPR029020 Ammonium/urea transporter SPH21_RS16045 4b91a5056a4ee6a9511ee6c6312c41bd 438 ProSitePatterns PS01219 Ammonium transporters signature. 198 223 - T 21-04-2016 IPR018047 Ammonium transporter, conserved site GO:0008519|GO:0016020|GO:0072488 SPH21_RS22385 417bc47e030a6ed531f17d2a39d2444f 296 TIGRFAM TIGR02138 phosphate_pstC: phosphate ABC transporter, permease protein PstC 8 291 2.0E-81 T 21-04-2016 IPR011864 Phosphate ABC transporter, permease protein PstC GO:0005315|GO:0006817|GO:0016021 SPH21_RS22385 417bc47e030a6ed531f17d2a39d2444f 296 Gene3D G3DSA:1.10.3720.10 20 292 2.7E-43 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS22385 417bc47e030a6ed531f17d2a39d2444f 296 PANTHER PTHR30425 1 291 1.4E-91 T 21-04-2016 SPH21_RS22385 417bc47e030a6ed531f17d2a39d2444f 296 SUPERFAMILY SSF161098 46 285 1.7E-39 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS22385 417bc47e030a6ed531f17d2a39d2444f 296 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 89 289 1.9E-25 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS07385 19a6c95d37498e2cf65b46d40340a1c4 235 Gene3D G3DSA:3.30.950.10 122 234 2.9E-28 T 21-04-2016 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 SPH21_RS07385 19a6c95d37498e2cf65b46d40340a1c4 235 PANTHER PTHR21091 31 186 2.1E-21 T 21-04-2016 SPH21_RS07385 19a6c95d37498e2cf65b46d40340a1c4 235 SUPERFAMILY SSF53790 3 234 7.72E-67 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS07385 19a6c95d37498e2cf65b46d40340a1c4 235 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 65 210 1.0E-8 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS07385 19a6c95d37498e2cf65b46d40340a1c4 235 PANTHER PTHR21091:SF18 31 186 2.1E-21 T 21-04-2016 SPH21_RS07385 19a6c95d37498e2cf65b46d40340a1c4 235 PIRSF PIRSF005917 1 235 7.4E-50 T 21-04-2016 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS07385 19a6c95d37498e2cf65b46d40340a1c4 235 Gene3D G3DSA:3.40.1010.10 28 120 8.2E-5 T 21-04-2016 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 SPH21_RS04090 9fea29413a6091f8d1d3531721967ec3 325 PANTHER PTHR23200 39 322 3.4E-68 T 21-04-2016 SPH21_RS04090 9fea29413a6091f8d1d3531721967ec3 325 SUPERFAMILY SSF56281 35 315 8.12E-49 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS04090 9fea29413a6091f8d1d3531721967ec3 325 Pfam PF00753 Metallo-beta-lactamase superfamily 88 278 2.5E-21 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS04090 9fea29413a6091f8d1d3531721967ec3 325 PANTHER PTHR23200:SF46 39 322 3.4E-68 T 21-04-2016 SPH21_RS04090 9fea29413a6091f8d1d3531721967ec3 325 SMART SM00849 88 293 1.1E-18 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS04090 9fea29413a6091f8d1d3531721967ec3 325 Gene3D G3DSA:3.60.15.10 35 315 1.1E-58 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS03375 891c5f4651db0e5f9b58922f4cf9d9fb 178 TIGRFAM TIGR02274 dCTP_deam: deoxycytidine triphosphate deaminase 2 165 1.8E-32 T 21-04-2016 IPR011962 Deoxycytidine triphosphate deaminase GO:0006229|GO:0008829 KEGG: 00240+3.5.4.13|MetaCyc: PWY-7187|UniPathway: UPA00610 SPH21_RS03375 891c5f4651db0e5f9b58922f4cf9d9fb 178 PANTHER PTHR11241 1 175 4.5E-46 T 21-04-2016 SPH21_RS03375 891c5f4651db0e5f9b58922f4cf9d9fb 178 PANTHER PTHR11241:SF1 1 175 4.5E-46 T 21-04-2016 SPH21_RS03375 891c5f4651db0e5f9b58922f4cf9d9fb 178 Gene3D G3DSA:2.70.40.10 1 165 2.6E-41 T 21-04-2016 IPR029054 dUTPase-like SPH21_RS03375 891c5f4651db0e5f9b58922f4cf9d9fb 178 SUPERFAMILY SSF51283 1 165 2.75E-40 T 21-04-2016 IPR029054 dUTPase-like SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 SUPERFAMILY SSF51246 332 424 3.53E-23 T 21-04-2016 IPR011054 Rudiment single hybrid motif SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Hamap MF_00138 Phosphoribosylamine--glycine ligase [purD]. 1 424 36.534 T 21-04-2016 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Pfam PF02844 Phosphoribosylglycinamide synthetase, N domain 1 104 9.2E-30 T 21-04-2016 IPR020562 Phosphoribosylglycinamide synthetase, N-terminal GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 PANTHER PTHR10520 1 421 1.2E-198 T 21-04-2016 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 SUPERFAMILY SSF52440 1 105 2.16E-29 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Gene3D G3DSA:3.90.600.10 334 421 9.1E-26 T 21-04-2016 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Gene3D G3DSA:3.30.470.20 195 331 5.3E-51 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 SMART SM01209 105 299 2.9E-115 T 21-04-2016 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 SUPERFAMILY SSF56059 106 320 1.29E-51 T 21-04-2016 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Pfam PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 105 299 3.2E-67 T 21-04-2016 IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 TIGRFAM TIGR00877 purD: phosphoribosylamine--glycine ligase 1 423 2.3E-138 T 21-04-2016 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Gene3D G3DSA:3.40.50.20 2 97 1.8E-29 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 SMART SM01210 333 424 1.2E-37 T 21-04-2016 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Gene3D G3DSA:3.30.1490.20 130 194 1.2E-23 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS07395 0a64dfc9004964f750c1b9ab3ebf8c66 426 Pfam PF02843 Phosphoribosylglycinamide synthetase, C domain 334 421 3.9E-23 T 21-04-2016 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|UniPathway: UPA00074 SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 Gene3D G3DSA:3.40.50.300 4 257 2.9E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 SMART SM00382 362 520 9.4E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 SMART SM00382 27 211 3.9E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 SUPERFAMILY SSF52540 329 517 1.58E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 PANTHER PTHR19211 282 519 3.1E-108 T 21-04-2016 SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 PANTHER PTHR19211 1 248 3.1E-108 T 21-04-2016 SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 Pfam PF00005 ABC transporter 354 485 3.3E-20 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 Pfam PF00005 ABC transporter 19 167 2.4E-21 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 SUPERFAMILY SSF52540 2 79 1.99E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 SUPERFAMILY SSF52540 108 239 1.99E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS04785 52f6f89a565c9eff50a5bcd4b3437262 527 Gene3D G3DSA:3.40.50.300 340 519 1.8E-32 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21335 3b10fc8c913928fae9de7a7ca68dcc8a 394 PANTHER PTHR30273:SF2 1 118 1.6E-66 T 21-04-2016 SPH21_RS21335 3b10fc8c913928fae9de7a7ca68dcc8a 394 PANTHER PTHR30273:SF2 182 390 1.6E-66 T 21-04-2016 SPH21_RS21335 3b10fc8c913928fae9de7a7ca68dcc8a 394 PANTHER PTHR30273 1 118 1.6E-66 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21335 3b10fc8c913928fae9de7a7ca68dcc8a 394 PANTHER PTHR30273 182 390 1.6E-66 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21335 3b10fc8c913928fae9de7a7ca68dcc8a 394 Pfam PF04773 FecR protein 180 274 1.5E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS21335 3b10fc8c913928fae9de7a7ca68dcc8a 394 Pfam PF16344 Domain of unknown function (DUF4974) 288 382 2.0E-18 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS18575 54b410459a3f49df7adb6db65a72ad32 257 Pfam PF06884 Protein of unknown function (DUF1264) 50 215 2.3E-69 T 21-04-2016 IPR010686 Protein of unknown function DUF1264 SPH21_RS18575 54b410459a3f49df7adb6db65a72ad32 257 PANTHER PTHR31360:SF3 12 256 1.0E-104 T 21-04-2016 SPH21_RS18575 54b410459a3f49df7adb6db65a72ad32 257 PANTHER PTHR31360 12 256 1.0E-104 T 21-04-2016 SPH21_RS20305 8e900966179afa794c18b8ca678caf1c 262 SUPERFAMILY SSF50249 1 62 2.08E-7 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS20305 8e900966179afa794c18b8ca678caf1c 262 Gene3D G3DSA:2.40.50.140 1 62 4.4E-10 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS20305 8e900966179afa794c18b8ca678caf1c 262 Pfam PF00313 'Cold-shock' DNA-binding domain 4 61 5.6E-7 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 PANTHER PTHR32282:SF11 420 704 1.4E-155 T 21-04-2016 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 PANTHER PTHR32282:SF11 17 344 1.4E-155 T 21-04-2016 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 Pfam PF00912 Transglycosylase 73 251 6.0E-54 T 21-04-2016 IPR001264 Glycosyl transferase, family 51 UniPathway: UPA00219 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 Gene3D G3DSA:3.40.710.10 419 725 3.6E-106 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 Gene3D G3DSA:3.40.710.10 255 347 3.6E-106 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 Pfam PF00905 Penicillin binding protein transpeptidase domain 429 660 3.0E-25 T 21-04-2016 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 SUPERFAMILY SSF53955 60 276 1.21E-61 T 21-04-2016 IPR023346 Lysozyme-like domain SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 Gene3D G3DSA:1.10.3810.10 73 254 8.5E-63 T 21-04-2016 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 PANTHER PTHR32282 420 704 1.4E-155 T 21-04-2016 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 PANTHER PTHR32282 17 344 1.4E-155 T 21-04-2016 SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 SUPERFAMILY SSF56601 233 255 8.55E-104 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 SUPERFAMILY SSF56601 419 722 8.55E-104 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS25795 01265169ddde74ff73dac603655281c1 746 SUPERFAMILY SSF56601 285 347 8.55E-104 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 SMART SM00342 92 174 3.2E-11 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 Gene3D G3DSA:1.10.10.60 129 179 1.8E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 Pfam PF12833 Helix-turn-helix domain 98 174 4.1E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 PANTHER PTHR11019:SF50 100 182 2.1E-16 T 21-04-2016 SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 128 170 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 Gene3D G3DSA:3.30.70.100 3 62 2.5E-4 T 21-04-2016 SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 PANTHER PTHR11019 100 182 2.1E-16 T 21-04-2016 SPH21_RS23560 424c13336ffe91b58ac6c91a50673638 187 SUPERFAMILY SSF46689 128 175 5.82E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 Pfam PF16320 Ribosomal protein L7/L12 dimerisation domain 5 49 6.1E-13 T 21-04-2016 IPR008932 Ribosomal protein L7/L12, oligomerisation GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 TIGRFAM TIGR00855 L12: ribosomal protein bL12 2 125 1.6E-37 T 21-04-2016 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 Gene3D G3DSA:3.30.1390.10 53 125 2.3E-31 T 21-04-2016 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 Pfam PF00542 Ribosomal protein L7/L12 C-terminal domain 59 125 3.3E-28 T 21-04-2016 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 SUPERFAMILY SSF54736 54 125 8.72E-24 T 21-04-2016 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 ProDom PD001326 RIBOSOMAL L7/L12 50S RIBONUCLEOPROTEIN CHLOROPLAST L12 PLASTID DIRECT SEQUENCING PEPTIDE 60 125 1.0E-11 T 21-04-2016 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 Gene3D G3DSA:1.20.5.710 9 50 1.3E-7 T 21-04-2016 SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 SUPERFAMILY SSF48300 4 61 9.81E-12 T 21-04-2016 IPR008932 Ribosomal protein L7/L12, oligomerisation GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11900 541f2bd2fddc689151195967b7d58b15 125 Hamap MF_00368 50S ribosomal protein L7/L12 [rplL]. 1 125 22.381 T 21-04-2016 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS07295 1392465f0afd7e44efbc851acef61818 104 SUPERFAMILY SSF52833 3 101 4.29E-23 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07295 1392465f0afd7e44efbc851acef61818 104 PANTHER PTHR10438 7 104 5.7E-19 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS07295 1392465f0afd7e44efbc851acef61818 104 Gene3D G3DSA:3.40.30.10 3 102 2.5E-24 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07295 1392465f0afd7e44efbc851acef61818 104 Pfam PF00085 Thioredoxin 4 99 1.5E-20 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS07295 1392465f0afd7e44efbc851acef61818 104 PRINTS PR00421 Thioredoxin family signature 67 78 3.3E-5 T 21-04-2016 SPH21_RS07295 1392465f0afd7e44efbc851acef61818 104 PRINTS PR00421 Thioredoxin family signature 28 37 3.3E-5 T 21-04-2016 SPH21_RS07295 1392465f0afd7e44efbc851acef61818 104 PRINTS PR00421 Thioredoxin family signature 20 28 3.3E-5 T 21-04-2016 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 209 308 8.7E-13 T 21-04-2016 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726|UniPathway: UPA00659 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 Pfam PF00378 Enoyl-CoA hydratase/isomerase 512 639 1.9E-10 T 21-04-2016 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 Gene3D G3DSA:1.10.1040.10 211 308 2.3E-16 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 8 206 1.9E-42 T 21-04-2016 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726|UniPathway: UPA00659 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 PANTHER PTHR23309 6 486 1.9E-118 T 21-04-2016 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 PANTHER PTHR23309:SF2 6 486 1.9E-118 T 21-04-2016 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 SUPERFAMILY SSF51735 5 207 9.42E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 Gene3D G3DSA:3.90.226.10 512 640 5.1E-22 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 SUPERFAMILY SSF48179 207 318 2.64E-20 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 Gene3D G3DSA:3.40.50.720 4 210 5.2E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 Gene3D G3DSA:1.10.1040.10 388 448 3.0E-8 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 SUPERFAMILY SSF52096 498 806 2.19E-34 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS00105 29c9f3c17c123d548d291fadceec9d5c 809 SUPERFAMILY SSF48179 368 472 1.11E-14 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS23330 51046ad12e9a7c1f56d8863bea4ff5e2 239 SUPERFAMILY SSF56300 4 237 3.8E-34 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS23330 51046ad12e9a7c1f56d8863bea4ff5e2 239 Gene3D G3DSA:3.60.21.10 4 234 1.2E-22 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS23330 51046ad12e9a7c1f56d8863bea4ff5e2 239 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 4 193 6.0E-15 T 21-04-2016 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type SPH21_RS14770 2538b2ab08579bc0bc6bcafb9f76545c 286 Pfam PF00682 HMGL-like 8 275 3.7E-25 T 21-04-2016 IPR000891 Pyruvate carboxyltransferase GO:0003824 SPH21_RS14770 2538b2ab08579bc0bc6bcafb9f76545c 286 Gene3D G3DSA:3.20.20.70 2 282 5.3E-48 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS14770 2538b2ab08579bc0bc6bcafb9f76545c 286 PANTHER PTHR10277 1 273 3.3E-88 T 21-04-2016 SPH21_RS14770 2538b2ab08579bc0bc6bcafb9f76545c 286 SUPERFAMILY SSF51569 2 284 1.04E-45 T 21-04-2016 SPH21_RS14770 2538b2ab08579bc0bc6bcafb9f76545c 286 PANTHER PTHR10277:SF1 1 273 3.3E-88 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Gene3D G3DSA:2.40.170.20 1043 1142 4.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Gene3D G3DSA:2.40.170.20 333 352 4.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Gene3D G3DSA:2.40.170.20 430 898 4.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Gene3D G3DSA:2.40.170.20 969 994 4.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 SUPERFAMILY SSF49464 127 208 1.57E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 SMART SM00965 69 120 0.0016 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Gene3D G3DSA:2.170.130.10 214 332 5.4E-25 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 SUPERFAMILY SSF56935 207 356 1.87E-98 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 SUPERFAMILY SSF56935 547 888 1.87E-98 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 SUPERFAMILY SSF56935 960 1004 1.87E-98 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 SUPERFAMILY SSF56935 421 509 1.87E-98 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 SUPERFAMILY SSF56935 1049 1142 1.87E-98 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 PANTHER PTHR11532:SF57 125 475 1.3E-272 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 PANTHER PTHR11532:SF57 583 1140 1.3E-272 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 128 1142 1.9E-281 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 308 338 9.1E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Pfam PF13715 CarboxypepD_reg-like domain 129 210 6.5E-17 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 PANTHER PTHR11532 125 475 1.3E-272 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 PANTHER PTHR11532 583 1140 1.3E-272 T 21-04-2016 SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Gene3D G3DSA:2.60.40.1120 129 213 6.4E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS21840 243ec4f558aa33b75e03541e012db9de 1142 Pfam PF07715 TonB-dependent Receptor Plug Domain 219 332 1.1E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS15225 4b928c2585476758022d1bc1f1d4df2c 201 PANTHER PTHR15160 14 197 5.5E-37 T 21-04-2016 SPH21_RS15225 4b928c2585476758022d1bc1f1d4df2c 201 Pfam PF02577 Bifunctional nuclease 8 135 1.3E-44 T 21-04-2016 IPR003729 Bifunctional nuclease domain GO:0004518 SPH21_RS15225 4b928c2585476758022d1bc1f1d4df2c 201 Gene3D G3DSA:4.10.860.10 170 197 7.5E-4 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS15225 4b928c2585476758022d1bc1f1d4df2c 201 PANTHER PTHR15160:SF1 14 197 5.5E-37 T 21-04-2016 SPH21_RS15225 4b928c2585476758022d1bc1f1d4df2c 201 SUPERFAMILY SSF103256 4 138 5.89E-40 T 21-04-2016 IPR003729 Bifunctional nuclease domain GO:0004518 SPH21_RS15225 4b928c2585476758022d1bc1f1d4df2c 201 Pfam PF02151 UvrB/uvrC motif 171 197 1.0E-5 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS23995 9438e751e99bf9afdb40bc10bd0c646a 461 Pfam PF02321 Outer membrane efflux protein 48 244 2.0E-21 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS23995 9438e751e99bf9afdb40bc10bd0c646a 461 Pfam PF02321 Outer membrane efflux protein 279 454 1.2E-19 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS23995 9438e751e99bf9afdb40bc10bd0c646a 461 SUPERFAMILY SSF56954 17 457 1.44E-59 T 21-04-2016 SPH21_RS23995 9438e751e99bf9afdb40bc10bd0c646a 461 Gene3D G3DSA:1.20.1600.10 41 459 2.0E-48 T 21-04-2016 SPH21_RS23995 9438e751e99bf9afdb40bc10bd0c646a 461 PANTHER PTHR30026 25 461 5.1E-37 T 21-04-2016 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 Gene3D G3DSA:3.20.20.210 404 768 2.8E-130 T 21-04-2016 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 SUPERFAMILY SSF51726 407 767 7.06E-119 T 21-04-2016 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 SUPERFAMILY SSF51726 4 404 1.2E-110 T 21-04-2016 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 TIGRFAM TIGR01371 met_syn_B12ind: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 7 767 0.0 T 21-04-2016 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702|UniPathway: UPA00051 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 Hamap MF_00172 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [metE]. 2 769 36.766 T 21-04-2016 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702|UniPathway: UPA00051 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 PANTHER PTHR30519:SF0 1 767 0.0 T 21-04-2016 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 Pfam PF01717 Cobalamin-independent synthase, Catalytic domain 443 764 1.1E-153 T 21-04-2016 IPR002629 Cobalamin-independent methionine synthase MetE, C-terminal/archaeal GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702|UniPathway: UPA00051 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 PIRSF PIRSF000382 1 772 0.0 T 21-04-2016 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702|UniPathway: UPA00051 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 Gene3D G3DSA:3.20.20.210 4 400 4.3E-146 T 21-04-2016 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 PANTHER PTHR30519 1 767 0.0 T 21-04-2016 SPH21_RS25925 454ed3aa725d4590904496900b0db9b3 773 Pfam PF08267 Cobalamin-independent synthase, N-terminal domain 4 317 5.0E-123 T 21-04-2016 IPR013215 Cobalamin-independent methionine synthase MetE, N-terminal GO:0003871|GO:0008270|GO:0008652 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702|UniPathway: UPA00051 SPH21_RS15035 66bcac696a8ce0a56aba697346c8c494 900 Gene3D G3DSA:2.60.120.260 774 884 4.6E-9 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS15035 66bcac696a8ce0a56aba697346c8c494 900 Gene3D G3DSA:1.50.10.10 319 459 1.2E-6 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS15035 66bcac696a8ce0a56aba697346c8c494 900 SUPERFAMILY SSF48208 269 643 2.62E-41 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS15035 66bcac696a8ce0a56aba697346c8c494 900 Pfam PF05592 Bacterial alpha-L-rhamnosidase 312 485 1.6E-10 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS15035 66bcac696a8ce0a56aba697346c8c494 900 SUPERFAMILY SSF49785 758 880 9.69E-7 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22480 2d3168f4fc0a4e1ae22724a1d1eef566 417 Pfam PF01103 Surface antigen 219 365 7.2E-6 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS07555 3e7496f5f8fb140637d57baa946bcb74 137 Pfam PF01850 PIN domain 6 126 3.7E-10 T 21-04-2016 IPR002716 PIN domain SPH21_RS07555 3e7496f5f8fb140637d57baa946bcb74 137 PANTHER PTHR33653:SF4 1 124 5.8E-18 T 21-04-2016 SPH21_RS07555 3e7496f5f8fb140637d57baa946bcb74 137 SUPERFAMILY SSF88723 3 132 3.36E-18 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS07555 3e7496f5f8fb140637d57baa946bcb74 137 Gene3D G3DSA:3.40.50.1010 3 134 9.2E-15 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS07555 3e7496f5f8fb140637d57baa946bcb74 137 PANTHER PTHR33653 1 124 5.8E-18 T 21-04-2016 SPH21_RS01035 5f9c0370c63e7c8919b1f43651d00910 153 Pfam PF14088 Domain of unknown function (DUF4268) 10 144 1.1E-32 T 21-04-2016 IPR025364 Domain of unknown function DUF4268 SPH21_RS03530 7b1659880da368e7d639fb53cc3cfac6 245 PANTHER PTHR24220:SF497 4 235 4.3E-138 T 21-04-2016 SPH21_RS03530 7b1659880da368e7d639fb53cc3cfac6 245 SUPERFAMILY SSF52540 2 226 3.08E-61 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03530 7b1659880da368e7d639fb53cc3cfac6 245 PANTHER PTHR24220 4 235 4.3E-138 T 21-04-2016 SPH21_RS03530 7b1659880da368e7d639fb53cc3cfac6 245 Pfam PF00005 ABC transporter 19 164 6.4E-33 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS03530 7b1659880da368e7d639fb53cc3cfac6 245 SMART SM00382 27 243 3.9E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS03530 7b1659880da368e7d639fb53cc3cfac6 245 Gene3D G3DSA:3.40.50.300 2 228 2.6E-66 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03530 7b1659880da368e7d639fb53cc3cfac6 245 TIGRFAM TIGR04406 LPS_export_lptB: LPS export ABC transporter ATP-binding protein 3 239 8.9E-113 T 21-04-2016 IPR030921 LPS export ABC transporter, ATP-binding protein LptB GO:0043190|GO:0055085 SPH21_RS21105 c6d40ecf5cd8d7df4383d0cbb17ae87f 531 Gene3D G3DSA:1.25.40.10 203 325 7.0E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21105 c6d40ecf5cd8d7df4383d0cbb17ae87f 531 Gene3D G3DSA:1.25.40.10 364 461 7.0E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21105 c6d40ecf5cd8d7df4383d0cbb17ae87f 531 Pfam PF14322 Starch-binding associating with outer membrane 24 221 5.7E-20 T 21-04-2016 SPH21_RS21105 c6d40ecf5cd8d7df4383d0cbb17ae87f 531 SUPERFAMILY SSF48452 20 531 1.77E-85 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21105 c6d40ecf5cd8d7df4383d0cbb17ae87f 531 Pfam PF07980 SusD family 334 531 3.2E-32 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS12835 15c5b77acf2b78ac4777cdc2e876e8bb 138 Pfam PF03203 MerC mercury resistance protein 10 119 1.3E-27 T 21-04-2016 IPR004891 MerC mercury resistance protein SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 Gene3D G3DSA:2.170.130.10 109 180 4.7E-5 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 Gene3D G3DSA:2.60.40.1120 3 85 1.4E-5 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 SUPERFAMILY SSF49464 2 70 1.31E-7 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 SUPERFAMILY SSF56935 758 770 1.51E-15 T 21-04-2016 SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 SUPERFAMILY SSF56935 385 714 1.51E-15 T 21-04-2016 SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 SUPERFAMILY SSF56935 803 868 1.51E-15 T 21-04-2016 SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 SUPERFAMILY SSF56935 80 217 1.51E-15 T 21-04-2016 SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 SUPERFAMILY SSF56935 293 344 1.51E-15 T 21-04-2016 SPH21_RS20210 3b33a766c6c5f8f42147a80fe39405dd 869 Pfam PF13620 Carboxypeptidase regulatory-like domain 3 68 2.7E-7 T 21-04-2016 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 Pfam PF12833 Helix-turn-helix domain 201 279 9.0E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 232 274 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 Gene3D G3DSA:2.60.120.280 28 103 7.1E-11 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 Gene3D G3DSA:2.60.120.280 153 160 7.1E-11 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 Pfam PF02311 AraC-like ligand binding domain 37 129 1.1E-11 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 PANTHER PTHR11019 6 286 5.0E-43 T 21-04-2016 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 PANTHER PTHR11019:SF45 6 286 5.0E-43 T 21-04-2016 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 SUPERFAMILY SSF51215 37 112 3.01E-11 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 SMART SM00342 195 278 1.1E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 SUPERFAMILY SSF46689 231 281 3.85E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS17155 cfb9d2a8fa320eba160d70e42ded033a 287 Gene3D G3DSA:1.10.10.60 230 280 2.0E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 PANTHER PTHR23514 1 168 4.1E-124 T 21-04-2016 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 PANTHER PTHR23514 186 411 4.1E-124 T 21-04-2016 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 TIGRFAM TIGR01272 gluP: glucose/galactose transporter WARNING 91 409 5.3E-72 T 21-04-2016 IPR005964 Bacterial glucose/galactose transporter GO:0005354|GO:0005355|GO:0009276|GO:0015757|GO:0015758|GO:0016021 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 PANTHER PTHR23514:SF7 1 168 4.1E-124 T 21-04-2016 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 PANTHER PTHR23514:SF7 186 411 4.1E-124 T 21-04-2016 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 SUPERFAMILY SSF103473 7 159 3.14E-41 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS03105 641609d734d0789366c9cb075be82008 418 SUPERFAMILY SSF103473 191 412 3.14E-41 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS03105 641609d734d0789366c9cb075be82008 418 Gene3D G3DSA:1.20.1250.20 221 411 7.9E-9 T 21-04-2016 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 Gene3D G3DSA:1.20.1250.20 11 217 1.7E-21 T 21-04-2016 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 TIGRFAM TIGR00885 fucP: L-fucose:H+ symporter permease 7 411 1.3E-119 T 21-04-2016 IPR005275 L-fucose permease FucP GO:0015150|GO:0015756 SPH21_RS03105 641609d734d0789366c9cb075be82008 418 Pfam PF07690 Major Facilitator Superfamily 15 378 1.0E-29 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS04765 c3790d7410dd5474272de84ef98ea851 327 PANTHER PTHR30273:SF2 8 326 1.3E-46 T 21-04-2016 SPH21_RS04765 c3790d7410dd5474272de84ef98ea851 327 PIRSF PIRSF018266 4 326 3.4E-49 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS04765 c3790d7410dd5474272de84ef98ea851 327 Pfam PF16344 Domain of unknown function (DUF4974) 229 321 3.5E-9 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS04765 c3790d7410dd5474272de84ef98ea851 327 Pfam PF04773 FecR protein 120 214 2.6E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS04765 c3790d7410dd5474272de84ef98ea851 327 PANTHER PTHR30273 8 326 1.3E-46 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS15660 7c102e4956f86f57f206891ad1d2209e 723 Pfam PF00999 Sodium/hydrogen exchanger family 26 391 1.5E-57 T 21-04-2016 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SPH21_RS15660 7c102e4956f86f57f206891ad1d2209e 723 Gene3D G3DSA:3.40.50.620 406 542 1.2E-6 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15660 7c102e4956f86f57f206891ad1d2209e 723 PANTHER PTHR32468:SF9 12 543 4.7E-100 T 21-04-2016 SPH21_RS15660 7c102e4956f86f57f206891ad1d2209e 723 PANTHER PTHR32468 12 543 4.7E-100 T 21-04-2016 SPH21_RS15660 7c102e4956f86f57f206891ad1d2209e 723 SUPERFAMILY SSF52402 417 545 1.26E-6 T 21-04-2016 SPH21_RS24345 38a7cc23c91eda8c6941c8d30fa5713c 122 SUPERFAMILY SSF88697 1 119 1.79E-22 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS24345 38a7cc23c91eda8c6941c8d30fa5713c 122 Pfam PF04266 ASCH domain 5 95 3.3E-5 T 21-04-2016 IPR007374 ASCH domain SPH21_RS24345 38a7cc23c91eda8c6941c8d30fa5713c 122 Gene3D G3DSA:2.30.130.30 3 112 2.9E-14 T 21-04-2016 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Gene3D G3DSA:3.30.565.10 533 658 1.6E-15 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Pfam PF07730 Histidine kinase 466 527 1.1E-8 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Pfam PF13181 Tetratricopeptide repeat 170 195 0.14 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 SUPERFAMILY SSF55874 534 654 4.71E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Gene3D G3DSA:1.25.40.10 234 348 3.7E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 SUPERFAMILY SSF48452 162 372 3.23E-18 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Gene3D G3DSA:1.25.40.10 183 233 6.1E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 PANTHER PTHR24421:SF1 414 659 1.4E-37 T 21-04-2016 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 567 655 3.6E-11 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 SMART SM00028 250 283 3.4 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 SMART SM00028 209 242 210.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 SMART SM00028 168 201 19.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 PANTHER PTHR24421 414 659 1.4E-37 T 21-04-2016 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Gene3D G3DSA:1.25.40.10 44 110 9.2E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 Gene3D G3DSA:1.25.40.10 150 182 9.2E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20460 e1683d78a93f6d737f69c3efcdb1f496 660 SMART SM00387 565 660 2.6E-8 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 PANTHER PTHR11444 4 444 8.9E-189 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 SUPERFAMILY SSF48557 4 444 9.9E-96 T 21-04-2016 IPR008948 L-Aspartase-like GO:0003824 SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 ProSitePatterns PS00163 Fumarate lyases signature. 291 300 - T 21-04-2016 IPR020557 Fumarate lyase, conserved site GO:0003824 SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 PANTHER PTHR11444:SF17 4 444 8.9E-189 T 21-04-2016 SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 Pfam PF08328 Adenylosuccinate lyase C-terminal 328 443 3.9E-48 T 21-04-2016 IPR013539 Adenylosuccinate lyase PurB, C-terminal GO:0004018|GO:0006188 KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00075 SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 Pfam PF00206 Lyase 14 309 2.1E-51 T 21-04-2016 IPR022761 Fumarate lyase, N-terminal SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 TIGRFAM TIGR00928 purB: adenylosuccinate lyase 12 444 5.4E-122 T 21-04-2016 IPR004769 Adenylosuccinate lyase GO:0004018|GO:0009152 KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00075 SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 Gene3D G3DSA:1.10.40.30 387 443 3.2E-26 T 21-04-2016 SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 PRINTS PR00149 Fumarate lyase superfamily signature 248 275 4.1E-14 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 PRINTS PR00149 Fumarate lyase superfamily signature 291 307 4.1E-14 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 PRINTS PR00149 Fumarate lyase superfamily signature 159 177 4.1E-14 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 PRINTS PR00149 Fumarate lyase superfamily signature 113 131 4.1E-14 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 Gene3D G3DSA:1.20.200.10 116 386 1.7E-78 T 21-04-2016 SPH21_RS18025 ffae1550e7bf5639c409a2a83c979777 445 Gene3D G3DSA:1.10.275.10 1 115 5.4E-43 T 21-04-2016 IPR024083 Fumarase/histidase, N-terminal SPH21_RS12050 30b345b531d095839bb2fd033b56e39a 368 PANTHER PTHR22916 37 313 1.8E-13 T 21-04-2016 SPH21_RS12050 30b345b531d095839bb2fd033b56e39a 368 Gene3D G3DSA:3.90.550.10 5 238 1.6E-16 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12050 30b345b531d095839bb2fd033b56e39a 368 Pfam PF00535 Glycosyl transferase family 2 6 113 3.6E-10 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS12050 30b345b531d095839bb2fd033b56e39a 368 SUPERFAMILY SSF53448 2 260 2.81E-26 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PANTHER PTHR11638 160 847 0.0 T 21-04-2016 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PANTHER PTHR11638 1 141 0.0 T 21-04-2016 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Gene3D G3DSA:1.10.8.60 365 448 6.4E-31 T 21-04-2016 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Pfam PF02151 UvrB/uvrC motif 437 469 2.2E-4 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Pfam PF07724 AAA domain (Cdc48 subfamily) 556 729 2.1E-52 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 736 815 2.2E-24 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 668 682 1.0E-42 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 561 579 1.0E-42 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 635 653 1.0E-42 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 606 624 1.0E-42 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 SUPERFAMILY SSF81923 4 141 5.49E-29 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 18 67 1.2E-17 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 96 142 4.6E-11 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PANTHER PTHR11638:SF18 160 847 0.0 T 21-04-2016 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 PANTHER PTHR11638:SF18 1 141 0.0 T 21-04-2016 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Gene3D G3DSA:3.40.50.300 183 361 3.4E-45 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 225 337 6.9E-12 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Gene3D G3DSA:1.10.1780.10 1 142 1.4E-37 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 315 327 - T 21-04-2016 IPR018368 ClpA/B, conserved site 1 GO:0005524 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 SMART SM01086 736 827 1.8E-34 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Gene3D G3DSA:1.10.8.60 746 836 1.2E-30 T 21-04-2016 SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 SMART SM00382 220 364 2.5E-12 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 SMART SM00382 557 729 1.3E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 SUPERFAMILY SSF52540 506 820 1.0E-75 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Gene3D G3DSA:3.40.50.300 719 745 1.0E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 Gene3D G3DSA:3.40.50.300 514 683 1.0E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02010 98297970a88ef428c453b0ddff987e3f 859 SUPERFAMILY SSF52540 181 485 4.31E-76 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 SUPERFAMILY SSF88659 130 190 2.99E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 Gene3D G3DSA:1.10.1740.10 16 120 3.3E-23 T 21-04-2016 SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 Gene3D G3DSA:1.10.10.10 130 191 1.6E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 PANTHER PTHR30173 29 190 6.3E-35 T 21-04-2016 SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 31 189 1.0E-25 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 Pfam PF08281 Sigma-70, region 4 135 187 2.5E-15 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 SUPERFAMILY SSF88946 20 119 5.02E-21 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11930 5cb96d3695754646f7c36812fc863188 200 Pfam PF04542 Sigma-70 region 2 35 108 2.2E-13 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 Pfam PF12833 Helix-turn-helix domain 228 305 4.2E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 SMART SM00342 221 304 1.6E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 Gene3D G3DSA:1.10.10.60 223 256 1.3E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 PANTHER PTHR11019:SF50 72 304 6.4E-39 T 21-04-2016 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 PANTHER PTHR11019 72 304 6.4E-39 T 21-04-2016 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 Gene3D G3DSA:1.10.10.60 260 305 1.0E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 SUPERFAMILY SSF46689 260 306 1.48E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 288 304 2.1E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS00650 4fc6805c36695c3e7459c4b67461f3f5 309 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 273 288 2.1E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 193 364 3.0E-58 T 21-04-2016 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 Gene3D G3DSA:2.60.120.260 373 486 1.6E-12 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 SUPERFAMILY SSF48208 488 886 1.22E-50 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 PANTHER PTHR33307:SF5 28 894 3.6E-287 T 21-04-2016 SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 PIRSF PIRSF010631 28 898 4.3E-282 T 21-04-2016 IPR016007 Alpha-L-rhamnosidase SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 PANTHER PTHR33307 28 894 3.6E-287 T 21-04-2016 SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 Pfam PF05592 Bacterial alpha-L-rhamnosidase 373 882 7.0E-165 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS02280 ff3be3aa97412df9ab3c0e6798d0af71 899 SUPERFAMILY SSF49785 156 265 2.55E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 Gene3D G3DSA:2.60.40.1120 26 95 1.4E-7 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 Pfam PF07715 TonB-dependent Receptor Plug Domain 119 226 6.7E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 PANTHER PTHR30069:SF2 29 555 4.2E-25 T 21-04-2016 SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 PANTHER PTHR30069 29 555 4.2E-25 T 21-04-2016 SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 SUPERFAMILY SSF49464 27 107 3.27E-11 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 Gene3D G3DSA:2.40.170.20 231 720 8.2E-50 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 SUPERFAMILY SSF56935 98 721 1.63E-79 T 21-04-2016 SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 Gene3D G3DSA:2.170.130.10 97 230 3.9E-30 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01090 ff129d2859dd9b2a36023262b77a6385 722 Pfam PF13715 CarboxypepD_reg-like domain 28 109 1.9E-12 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 Gene3D G3DSA:2.60.120.260 389 623 6.8E-81 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 Gene3D G3DSA:3.40.50.1820 9 194 2.1E-81 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 Gene3D G3DSA:3.40.50.1820 275 388 2.1E-81 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 SUPERFAMILY SSF49785 392 622 2.13E-58 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 PANTHER PTHR11731:SF151 30 203 9.7E-26 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 PANTHER PTHR11731:SF151 266 335 9.7E-26 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 PANTHER PTHR11731:SF151 351 380 9.7E-26 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 PANTHER PTHR11731 30 203 9.7E-26 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 PANTHER PTHR11731 266 335 9.7E-26 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 PANTHER PTHR11731 351 380 9.7E-26 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 42 621 1.6E-83 T 21-04-2016 IPR005674 CocE/Serine esterase GO:0016787 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 SUPERFAMILY SSF53474 14 395 2.34E-47 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 SMART SM00939 361 620 1.5E-71 T 21-04-2016 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 Gene3D G3DSA:1.10.3020.10 195 274 3.9E-22 T 21-04-2016 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 380 619 2.1E-35 T 21-04-2016 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SPH21_RS13965 6d6b775c23dd9a0e52234fc93488c7d8 624 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 45 332 1.1E-52 T 21-04-2016 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 Gene3D G3DSA:3.30.2090.10 728 813 5.1E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 SUPERFAMILY SSF82866 306 498 3.01E-48 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 Pfam PF00873 AcrB/AcrD/AcrF family 1 1033 0.0 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 SUPERFAMILY SSF82866 811 1033 1.1E-41 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 Gene3D G3DSA:1.10.3850.10 819 1033 5.8E-53 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 Gene3D G3DSA:1.10.3850.10 282 498 2.2E-55 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 Gene3D G3DSA:3.30.70.1430 574 677 3.0E-20 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 SUPERFAMILY SSF82714 185 271 3.27E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 SUPERFAMILY SSF82714 728 813 8.24E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 Gene3D G3DSA:3.30.70.1430 38 138 1.1E-32 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 SUPERFAMILY SSF82693 572 677 3.66E-20 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PANTHER PTHR32063:SF9 1 1041 0.0 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 Gene3D G3DSA:3.30.2090.10 184 272 1.9E-22 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 559 576 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 445 468 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 470 493 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 391 415 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 36 54 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 628 642 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 336 359 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 363 384 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PRINTS PR00702 Acriflavin resistance protein family signature 8 32 3.6E-94 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 PANTHER PTHR32063 1 1041 0.0 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 SUPERFAMILY SSF82693 38 131 5.75E-26 T 21-04-2016 SPH21_RS24155 e5ac4651e1b6bbb2c5ebb37171bcb80f 1065 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 1 1049 0.0 T 21-04-2016 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0005215|GO:0006810|GO:0016021 SPH21_RS16910 5457f58ed6b1f10e54f7f447865a95e3 145 SUPERFAMILY SSF55729 1 137 4.88E-23 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS16910 5457f58ed6b1f10e54f7f447865a95e3 145 Pfam PF13673 Acetyltransferase (GNAT) domain 54 129 3.3E-14 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS16910 5457f58ed6b1f10e54f7f447865a95e3 145 PANTHER PTHR23091:SF277 2 125 2.3E-27 T 21-04-2016 SPH21_RS16910 5457f58ed6b1f10e54f7f447865a95e3 145 PANTHER PTHR23091 2 125 2.3E-27 T 21-04-2016 SPH21_RS16910 5457f58ed6b1f10e54f7f447865a95e3 145 Gene3D G3DSA:3.40.630.30 2 135 3.8E-21 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 PANTHER PTHR11552 225 568 8.1E-47 T 21-04-2016 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 PANTHER PTHR11552 14 78 8.1E-47 T 21-04-2016 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 PANTHER PTHR11552 99 207 8.1E-47 T 21-04-2016 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 Pfam PF00732 GMC oxidoreductase 190 320 2.5E-10 T 21-04-2016 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 Pfam PF05199 GMC oxidoreductase 432 555 8.0E-19 T 21-04-2016 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 SUPERFAMILY SSF54373 359 503 4.71E-35 T 21-04-2016 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 SUPERFAMILY SSF51905 10 347 2.07E-57 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 SUPERFAMILY SSF51905 503 564 2.07E-57 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 PANTHER PTHR11552:SF139 225 568 8.1E-47 T 21-04-2016 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 PANTHER PTHR11552:SF139 14 78 8.1E-47 T 21-04-2016 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 PANTHER PTHR11552:SF139 99 207 8.1E-47 T 21-04-2016 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 Gene3D G3DSA:3.50.50.60 10 163 1.6E-66 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 Gene3D G3DSA:3.50.50.60 442 455 1.6E-66 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 Gene3D G3DSA:3.50.50.60 494 559 1.6E-66 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08200 aa0d1db16bf677f866de08090825278a 570 Gene3D G3DSA:3.50.50.60 237 345 1.6E-66 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 Pfam PF13450 NAD(P)-binding Rossmann-like domain 10 59 7.9E-10 T 21-04-2016 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 SUPERFAMILY SSF51905 1 299 1.3E-29 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 SUPERFAMILY SSF51905 428 471 1.3E-29 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 7 29 2.2E-6 T 21-04-2016 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 212 237 2.2E-6 T 21-04-2016 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 PANTHER PTHR10668 7 476 1.5E-151 T 21-04-2016 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 Gene3D G3DSA:3.50.50.60 315 338 1.2E-19 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 Gene3D G3DSA:3.50.50.60 405 471 1.2E-19 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 Gene3D G3DSA:3.50.50.60 2 57 1.2E-19 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 Gene3D G3DSA:3.50.50.60 210 256 1.2E-19 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS23290 83721f283ae5f1ac6ccec662b9d0f39d 477 PANTHER PTHR10668:SF74 7 476 1.5E-151 T 21-04-2016 SPH21_RS19610 6e7d9759a255a0928715603901867b1a 330 SUPERFAMILY SSF53756 1 302 2.29E-8 T 21-04-2016 SPH21_RS19610 6e7d9759a255a0928715603901867b1a 330 Pfam PF13528 Glycosyl transferase family 1 1 302 7.6E-38 T 21-04-2016 SPH21_RS19610 6e7d9759a255a0928715603901867b1a 330 Gene3D G3DSA:3.40.50.2000 220 302 6.8E-7 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423 724 763 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423 815 1057 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423 546 565 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423 583 657 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423 36 153 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 SMART SM00388 834 900 9.3E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 SMART SM00387 946 1055 3.6E-24 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Gene3D G3DSA:1.10.287.130 826 896 9.8E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Gene3D G3DSA:2.120.10.30 301 423 4.7E-9 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Gene3D G3DSA:2.120.10.30 550 655 9.3E-4 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Gene3D G3DSA:2.120.10.30 83 181 1.3E-5 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Gene3D G3DSA:2.120.10.30 471 524 4.7E-9 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 SUPERFAMILY SSF47384 824 899 5.69E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 SUPERFAMILY SSF63829 175 426 2.03E-15 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 947 1053 1.7E-13 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Pfam PF07494 Two component regulator propeller 490 512 0.0056 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Pfam PF07494 Two component regulator propeller 355 378 0.0078 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Pfam PF07494 Two component regulator propeller 44 66 0.0016 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Pfam PF07494 Two component regulator propeller 309 330 0.0022 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 SUPERFAMILY SSF55874 890 1053 3.8E-28 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Gene3D G3DSA:3.30.565.10 904 1058 4.1E-31 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423:SF486 724 763 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423:SF486 815 1057 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423:SF486 546 565 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423:SF486 583 657 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PANTHER PTHR24423:SF486 36 153 2.5E-67 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 SUPERFAMILY SSF63829 375 589 7.85E-15 T 21-04-2016 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Pfam PF00512 His Kinase A (phospho-acceptor) domain 835 899 4.1E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Gene3D G3DSA:2.120.10.30 185 262 5.1E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 Pfam PF07495 Y_Y_Y domain 716 779 6.7E-15 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1014 1032 8.1E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 PRINTS PR00344 Bacterial sensor protein C-terminal signature 999 1009 8.1E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS02910 1fe6441ad99414d03a47e9dafca0e3c4 1060 SUPERFAMILY SSF50969 56 249 6.75E-10 T 21-04-2016 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 Pfam PF00072 Response regulator receiver domain 4 116 6.1E-28 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 SUPERFAMILY SSF46894 146 215 1.97E-18 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 Gene3D G3DSA:1.10.10.10 121 215 1.5E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 SUPERFAMILY SSF52172 1 126 7.97E-32 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 Gene3D G3DSA:3.40.50.2300 1 120 6.6E-34 T 21-04-2016 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 PANTHER PTHR26402 2 212 5.6E-62 T 21-04-2016 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 SMART SM00421 152 209 1.5E-14 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 SMART SM00448 2 116 3.6E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 Pfam PF00196 Bacterial regulatory proteins, luxR family 157 209 4.0E-15 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 6.6E-10 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 6.6E-10 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 6.6E-10 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18970 6947d1f067712bf5b0a42bb9f5ceb03e 216 PANTHER PTHR26402:SF151 2 212 5.6E-62 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 Gene3D G3DSA:2.170.130.10 106 215 3.8E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 SUPERFAMILY SSF49464 16 96 7.85E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 15 980 4.4E-221 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 SUPERFAMILY SSF56935 94 237 2.43E-86 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 SUPERFAMILY SSF56935 275 364 2.43E-86 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 SUPERFAMILY SSF56935 891 980 2.43E-86 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 SUPERFAMILY SSF56935 397 745 2.43E-86 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 SUPERFAMILY SSF56935 817 861 2.43E-86 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 Gene3D G3DSA:2.60.40.1120 17 105 1.3E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 PANTHER PTHR11532:SF57 413 753 5.3E-206 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 Pfam PF13715 CarboxypepD_reg-like domain 17 98 3.4E-18 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 PANTHER PTHR11532:SF57 771 978 5.3E-206 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 PANTHER PTHR11532:SF57 12 337 5.3E-206 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 Gene3D G3DSA:2.40.170.20 284 745 8.5E-55 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 Gene3D G3DSA:2.40.170.20 794 980 8.5E-55 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 Gene3D G3DSA:2.40.170.20 216 233 8.5E-55 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 Pfam PF07715 TonB-dependent Receptor Plug Domain 108 212 3.8E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 188 218 1.9E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 PANTHER PTHR11532 12 337 5.3E-206 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 PANTHER PTHR11532 771 978 5.3E-206 T 21-04-2016 SPH21_RS21245 0300497b6f400ef8530c712fd974416f 980 PANTHER PTHR11532 413 753 5.3E-206 T 21-04-2016 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 2 24 6.3E-17 T 21-04-2016 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 291 307 6.3E-17 T 21-04-2016 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 145 160 6.3E-17 T 21-04-2016 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 276 291 6.3E-17 T 21-04-2016 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 PANTHER PTHR13789 1 347 1.1E-91 T 21-04-2016 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 SUPERFAMILY SSF51905 1 166 5.47E-61 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 SUPERFAMILY SSF51905 262 369 5.47E-61 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 PANTHER PTHR13789:SF186 1 347 1.1E-91 T 21-04-2016 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 Pfam PF01494 FAD binding domain 3 336 1.7E-22 T 21-04-2016 IPR002938 FAD-binding domain GO:0071949 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 Gene3D G3DSA:3.50.50.60 268 344 9.6E-37 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13460 a023682cb28fba8a8d1ec5d0b28b4c55 381 Gene3D G3DSA:3.50.50.60 1 171 9.6E-37 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS09945 1ccf6099ce276f44b13a43d84e8a78f7 481 PANTHER PTHR30250:SF0 1 457 1.3E-71 T 21-04-2016 SPH21_RS09945 1ccf6099ce276f44b13a43d84e8a78f7 481 PANTHER PTHR30250 1 457 1.3E-71 T 21-04-2016 SPH21_RS09945 1ccf6099ce276f44b13a43d84e8a78f7 481 Pfam PF14667 Polysaccharide biosynthesis C-terminal domain 329 464 1.5E-7 T 21-04-2016 IPR029303 Polysaccharide biosynthesis protein, C-terminal domain SPH21_RS09945 1ccf6099ce276f44b13a43d84e8a78f7 481 Pfam PF13440 Polysaccharide biosynthesis protein 32 326 4.3E-79 T 21-04-2016 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 Gene3D G3DSA:3.40.50.1470 1 186 9.0E-66 T 21-04-2016 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 Pfam PF01195 Peptidyl-tRNA hydrolase 4 182 1.2E-54 T 21-04-2016 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 ProSitePatterns PS01196 Peptidyl-tRNA hydrolase signature 2. 107 117 - T 21-04-2016 IPR018171 Peptidyl-tRNA hydrolase, conserved site GO:0004045 MetaCyc: PWY-6308 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 ProSitePatterns PS01195 Peptidyl-tRNA hydrolase signature 1. 15 28 - T 21-04-2016 IPR018171 Peptidyl-tRNA hydrolase, conserved site GO:0004045 MetaCyc: PWY-6308 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 PANTHER PTHR17224:SF1 3 186 4.5E-65 T 21-04-2016 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 SUPERFAMILY SSF53178 2 185 1.7E-57 T 21-04-2016 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 TIGRFAM TIGR00447 pth: aminoacyl-tRNA hydrolase 4 185 3.3E-52 T 21-04-2016 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 Hamap MF_00083 Peptidyl-tRNA hydrolase [pth]. 2 178 30.155 T 21-04-2016 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SPH21_RS25365 715a75714969add407c7d46d2bebd2b9 186 PANTHER PTHR17224 3 186 4.5E-65 T 21-04-2016 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SPH21_RS07750 24663c7e4db63c804c59feb2bae79e19 182 TIGRFAM TIGR01221 rmlC: dTDP-4-dehydrorhamnose 3,5-epimerase 2 177 2.6E-67 T 21-04-2016 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 SPH21_RS07750 24663c7e4db63c804c59feb2bae79e19 182 PANTHER PTHR21047 1 178 1.3E-68 T 21-04-2016 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 SPH21_RS07750 24663c7e4db63c804c59feb2bae79e19 182 ProDom PD001462 35-EPIMERASE DTDP-4-DEHYDRORHAMNOSE ISOMERASE RMLC EPIMERASE RELATED DTDP-6-DEOXY-D-GLUCOSE-35-EPIMERASE DTDP-4-KETO-6-DEOXY-D-GLUCOSE DTDP-4-KETO-6-DEOXYGLUCOSE-35-EPIMERASE DTDP-L-RHAMNOSE 1 177 5.0E-50 T 21-04-2016 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 SPH21_RS07750 24663c7e4db63c804c59feb2bae79e19 182 SUPERFAMILY SSF51182 1 180 1.6E-73 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS07750 24663c7e4db63c804c59feb2bae79e19 182 Pfam PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase 5 177 6.0E-70 T 21-04-2016 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 SPH21_RS07750 24663c7e4db63c804c59feb2bae79e19 182 Gene3D G3DSA:2.60.120.10 1 180 3.5E-76 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 SUPERFAMILY SSF53738 4 142 3.3E-32 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 PANTHER PTHR22573:SF48 1 459 9.4E-135 T 21-04-2016 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Gene3D G3DSA:3.40.120.10 5 151 1.8E-33 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Gene3D G3DSA:3.30.310.50 376 458 8.6E-19 T 21-04-2016 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Gene3D G3DSA:3.40.120.10 262 375 7.6E-27 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 SUPERFAMILY SSF53738 168 264 1.06E-24 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 SUPERFAMILY SSF55957 364 459 9.42E-23 T 21-04-2016 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Gene3D G3DSA:3.40.120.10 181 261 4.1E-24 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 168 262 3.6E-24 T 21-04-2016 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 269 372 1.2E-18 T 21-04-2016 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 PANTHER PTHR22573 1 459 9.4E-135 T 21-04-2016 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 98 107 - T 21-04-2016 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 394 455 3.6E-9 T 21-04-2016 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 TIGRFAM TIGR03990 Arch_GlmM: phosphoglucosamine mutase 4 453 5.6E-158 T 21-04-2016 IPR024086 Phosphoglucosamine mutase, archaeal type GO:0008966 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 97 111 2.1E-12 T 21-04-2016 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 180 199 2.1E-12 T 21-04-2016 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 242 257 2.1E-12 T 21-04-2016 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 SUPERFAMILY SSF53738 266 371 2.39E-21 T 21-04-2016 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS19835 27a849de7ef3385eb9493f9980799cfc 460 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 8 138 1.6E-31 T 21-04-2016 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SPH21_RS14140 d11ff67769a9f14e71ca30e34d41fb68 452 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 48 170 1.0E-15 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS14140 d11ff67769a9f14e71ca30e34d41fb68 452 SUPERFAMILY SSF51735 38 206 5.03E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14140 d11ff67769a9f14e71ca30e34d41fb68 452 PANTHER PTHR22604:SF122 2 432 4.8E-134 T 21-04-2016 SPH21_RS14140 d11ff67769a9f14e71ca30e34d41fb68 452 SUPERFAMILY SSF55347 185 359 8.28E-19 T 21-04-2016 SPH21_RS14140 d11ff67769a9f14e71ca30e34d41fb68 452 Gene3D G3DSA:3.40.50.720 43 183 4.4E-36 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14140 d11ff67769a9f14e71ca30e34d41fb68 452 PANTHER PTHR22604 2 432 4.8E-134 T 21-04-2016 SPH21_RS14140 d11ff67769a9f14e71ca30e34d41fb68 452 Gene3D G3DSA:3.30.360.10 184 418 5.4E-25 T 21-04-2016 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 PANTHER PTHR11019 215 348 6.4E-37 T 21-04-2016 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 Gene3D G3DSA:1.10.10.60 303 349 3.4E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 Pfam PF12833 Helix-turn-helix domain 271 348 3.7E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 PANTHER PTHR11019:SF61 215 348 6.4E-37 T 21-04-2016 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 302 344 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 SMART SM00342 265 348 1.2E-28 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 SUPERFAMILY SSF46689 302 349 1.66E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 317 332 5.1E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 332 348 5.1E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 SUPERFAMILY SSF46689 249 299 5.38E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26440 05d7781498c4d0fb281d5052be99b672 350 Gene3D G3DSA:1.10.10.60 248 301 1.3E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 SMART SM00922 135 226 4.0E-16 T 21-04-2016 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 SUPERFAMILY SSF54826 3 118 1.06E-19 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 PANTHER PTHR13794:SF60 2 333 2.0E-94 T 21-04-2016 SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 Gene3D G3DSA:3.20.20.120 122 334 8.7E-49 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 Pfam PF13378 Enolase C-terminal domain-like 139 335 1.3E-28 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 SUPERFAMILY SSF51604 123 333 3.14E-44 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 PANTHER PTHR13794 2 333 2.0E-94 T 21-04-2016 IPR001354 Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase GO:0003824|GO:0008152 SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 14 118 1.2E-7 T 21-04-2016 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SPH21_RS16185 30f7ee0abbbc569a57f4dd05d2f746bb 348 Gene3D G3DSA:3.30.390.10 8 121 3.2E-24 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS08895 837f8d314b55f860b3058f3d7ecac05d 318 Pfam PF00535 Glycosyl transferase family 2 6 135 2.2E-16 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS08895 837f8d314b55f860b3058f3d7ecac05d 318 PANTHER PTHR22916 1 290 2.7E-26 T 21-04-2016 SPH21_RS08895 837f8d314b55f860b3058f3d7ecac05d 318 Gene3D G3DSA:3.90.550.10 3 231 3.4E-33 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08895 837f8d314b55f860b3058f3d7ecac05d 318 SUPERFAMILY SSF53448 3 233 7.41E-33 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS18180 b9fff8f5bae4290906fa784be78b9278 644 Gene3D G3DSA:2.40.170.20 140 644 1.6E-49 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS18180 b9fff8f5bae4290906fa784be78b9278 644 Pfam PF07715 TonB-dependent Receptor Plug Domain 17 111 1.4E-14 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18180 b9fff8f5bae4290906fa784be78b9278 644 Pfam PF00593 TonB dependent receptor 390 643 2.2E-27 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS18180 b9fff8f5bae4290906fa784be78b9278 644 SUPERFAMILY SSF56935 9 644 3.19E-62 T 21-04-2016 SPH21_RS18180 b9fff8f5bae4290906fa784be78b9278 644 Gene3D G3DSA:2.170.130.10 5 111 6.1E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18180 b9fff8f5bae4290906fa784be78b9278 644 PANTHER PTHR32552:SF10 1 644 6.7E-13 T 21-04-2016 SPH21_RS18180 b9fff8f5bae4290906fa784be78b9278 644 PANTHER PTHR32552 1 644 6.7E-13 T 21-04-2016 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 Pfam PF16875 Glycosyl hydrolase family 36 N-terminal domain 49 283 3.2E-53 T 21-04-2016 IPR031704 Glycosyl hydrolase family 36, N-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 ProSitePatterns PS00512 Alpha-galactosidase signature. 356 374 - T 21-04-2016 IPR000111 Glycoside hydrolase family 27/36, conserved site GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PANTHER PTHR22762 327 666 2.6E-64 T 21-04-2016 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 Pfam PF02065 Melibiase 289 628 6.4E-106 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PIRSF PIRSF005536 23 732 2.2E-200 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 Gene3D G3DSA:3.20.20.70 329 612 2.3E-38 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 Pfam PF16874 Glycosyl hydrolase family 36 C-terminal domain 642 727 1.4E-11 T 21-04-2016 IPR031705 Glycosyl hydrolase family 36, C-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 544 560 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 408 430 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 519 535 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 355 370 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 467 482 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 240 255 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 291 311 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PRINTS PR00743 Glycosyl hydrolase family 36 signature 327 341 2.5E-43 T 21-04-2016 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 SUPERFAMILY SSF51445 326 658 5.27E-83 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS20180 3a25ed51f9a859a303ce5732145c017b 734 PANTHER PTHR22762:SF81 327 666 2.6E-64 T 21-04-2016 SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 SUPERFAMILY SSF51735 2 244 3.96E-63 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 Pfam PF00106 short chain dehydrogenase 2 183 9.1E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 Gene3D G3DSA:3.40.50.720 3 246 4.0E-65 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PANTHER PTHR24322 145 176 7.2E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PANTHER PTHR24322 6 129 7.2E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 183 2.6E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 2.6E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 2.6E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 119 135 2.6E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 164 2.6E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 211 231 2.6E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 145 164 7.7E-12 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 7.7E-12 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20750 2a0fb3c0b96a6acc38d4065b9932f4f1 280 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 125 133 7.7E-12 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 ProSitePatterns PS00211 ABC transporters family signature. 489 503 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 Pfam PF00005 ABC transporter 368 516 2.1E-33 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 SUPERFAMILY SSF90123 7 333 3.4E-66 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 Pfam PF00664 ABC transporter transmembrane region 24 306 6.4E-43 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 Gene3D G3DSA:1.20.1560.10 9 335 9.4E-66 T 21-04-2016 SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 SMART SM00382 377 563 5.9E-13 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 PANTHER PTHR24221 66 592 2.1E-191 T 21-04-2016 SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 PANTHER PTHR24221 9 48 2.1E-191 T 21-04-2016 SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 Gene3D G3DSA:3.40.50.300 351 582 9.7E-80 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19895 e387c617b09a33ca1fa0887ab5911950 593 SUPERFAMILY SSF52540 346 588 5.55E-87 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 SUPERFAMILY SSF52540 12 205 6.42E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 Gene3D G3DSA:3.40.50.300 370 426 4.2E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 Gene3D G3DSA:3.40.50.300 161 271 4.2E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 PANTHER PTHR23274 23 454 1.2E-109 T 21-04-2016 IPR003840 DNA helicase GO:0004386|GO:0005524 SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 Gene3D G3DSA:3.40.50.300 15 160 2.8E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 SUPERFAMILY SSF52540 374 442 9.43E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 SUPERFAMILY SSF52540 148 347 9.43E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 Pfam PF05970 PIF1-like helicase 16 223 3.3E-24 T 21-04-2016 IPR010285 DNA helicase Pif1-like GO:0000723|GO:0003678|GO:0006281 SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 Pfam PF14493 Helix-turn-helix domain 647 733 6.2E-18 T 21-04-2016 IPR029491 Helicase Helix-turn-helix domain SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 SMART SM00382 21 328 2.5E-6 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS08115 c4d061b3ef556fc4c168250299240a3b 746 Pfam PF02689 Helicase 371 426 1.6E-5 T 21-04-2016 IPR003840 DNA helicase GO:0004386|GO:0005524 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532:SF57 624 1063 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532:SF57 9 386 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532:SF57 442 494 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532:SF57 553 581 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 Pfam PF07715 TonB-dependent Receptor Plug Domain 117 227 1.1E-12 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 Gene3D G3DSA:2.40.170.20 339 410 3.7E-19 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 Gene3D G3DSA:2.40.170.20 444 834 3.7E-19 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 Gene3D G3DSA:2.170.130.10 106 231 8.4E-12 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 SUPERFAMILY SSF56935 464 834 3.66E-57 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 SUPERFAMILY SSF56935 104 252 3.66E-57 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 SUPERFAMILY SSF56935 899 964 3.66E-57 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 SUPERFAMILY SSF56935 332 420 3.66E-57 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 1065 1.3E-149 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532 624 1063 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532 9 386 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532 442 494 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 PANTHER PTHR11532 553 581 1.4E-114 T 21-04-2016 SPH21_RS09150 17f402b942aaba568c1cdbe25523ab1c 1065 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 203 233 9.4E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS11705 4835025b3a6158ce24ca95fbfc97a21e 454 Pfam PF07980 SusD family 331 454 1.6E-20 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS11705 4835025b3a6158ce24ca95fbfc97a21e 454 SUPERFAMILY SSF48452 18 454 3.29E-106 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11705 4835025b3a6158ce24ca95fbfc97a21e 454 Pfam PF14322 Starch-binding associating with outer membrane 22 224 1.8E-28 T 21-04-2016 SPH21_RS11705 4835025b3a6158ce24ca95fbfc97a21e 454 Gene3D G3DSA:1.25.40.10 204 405 2.0E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19975 65321e8b71f256f424faf456fe378706 343 Gene3D G3DSA:3.40.50.2000 167 340 1.8E-30 T 21-04-2016 SPH21_RS19975 65321e8b71f256f424faf456fe378706 343 Gene3D G3DSA:3.40.50.2000 6 150 2.5E-24 T 21-04-2016 SPH21_RS19975 65321e8b71f256f424faf456fe378706 343 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 72 284 4.3E-22 T 21-04-2016 IPR002201 Glycosyl transferase, family 9 GO:0008152|GO:0016757 SPH21_RS19975 65321e8b71f256f424faf456fe378706 343 PANTHER PTHR30160:SF7 2 341 2.0E-59 T 21-04-2016 SPH21_RS19975 65321e8b71f256f424faf456fe378706 343 SUPERFAMILY SSF53756 4 341 1.1E-62 T 21-04-2016 SPH21_RS19975 65321e8b71f256f424faf456fe378706 343 PANTHER PTHR30160 2 341 2.0E-59 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 SUPERFAMILY SSF49464 25 102 1.31E-11 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Gene3D G3DSA:2.170.130.10 106 237 4.9E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532 204 329 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532 350 463 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532 24 187 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532 558 1075 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Pfam PF13715 CarboxypepD_reg-like domain 25 104 1.4E-15 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532:SF51 204 329 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532:SF51 350 463 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532:SF51 24 187 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 PANTHER PTHR11532:SF51 558 1075 2.4E-184 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 213 242 3.5E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Gene3D G3DSA:2.60.40.1120 25 105 2.3E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Pfam PF07715 TonB-dependent Receptor Plug Domain 114 236 2.9E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Gene3D G3DSA:2.40.170.20 473 850 1.3E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Gene3D G3DSA:2.40.170.20 974 1030 1.3E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Gene3D G3DSA:2.40.170.20 238 258 1.3E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Gene3D G3DSA:2.40.170.20 888 913 1.3E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 Gene3D G3DSA:2.40.170.20 368 432 1.3E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 25 1077 3.2E-190 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 SUPERFAMILY SSF56935 889 910 2.27E-85 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 SUPERFAMILY SSF56935 358 450 2.27E-85 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 SUPERFAMILY SSF56935 482 821 2.27E-85 T 21-04-2016 SPH21_RS02480 8cf9a38bddf3a3bcb2a13d677e04c8b3 1077 SUPERFAMILY SSF56935 90 257 2.27E-85 T 21-04-2016 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 39 60 1.6E-11 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 75 93 1.6E-11 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 107 123 1.6E-11 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 132 149 1.6E-11 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 PIRSF PIRSF001365 2 306 7.3E-53 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 PANTHER PTHR12128 4 310 4.9E-59 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 SUPERFAMILY SSF51569 6 297 4.4E-57 T 21-04-2016 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 SMART SM01130 6 303 1.3E-48 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 Gene3D G3DSA:3.20.20.70 4 298 7.1E-62 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS04820 536019820e07e0ea2fa26f6ece420280 312 Pfam PF00701 Dihydrodipicolinate synthetase family 7 296 6.2E-45 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 345 459 2.4E-6 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 Gene3D G3DSA:2.60.120.260 41 201 8.9E-51 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 SUPERFAMILY SSF49303 215 305 8.35E-13 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 Gene3D G3DSA:3.20.20.80 318 592 7.3E-51 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 SUPERFAMILY SSF51445 302 590 9.78E-59 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 100 207 1.1E-17 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 PANTHER PTHR10066:SF44 34 594 2.0E-203 T 21-04-2016 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 SUPERFAMILY SSF49785 40 211 1.58E-44 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 Pfam PF00703 Glycosyl hydrolases family 2 236 305 1.9E-10 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 PANTHER PTHR10066 34 594 2.0E-203 T 21-04-2016 SPH21_RS22010 9fe6a3e9ad1f7eefe67d24d523765bbd 610 Gene3D G3DSA:2.60.40.320 202 305 3.8E-18 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS16590 e9e23aed7391c9dcb4a53e28c032edc8 552 PANTHER PTHR13285 375 518 9.8E-86 T 21-04-2016 SPH21_RS16590 e9e23aed7391c9dcb4a53e28c032edc8 552 PANTHER PTHR13285 33 327 9.8E-86 T 21-04-2016 SPH21_RS16590 e9e23aed7391c9dcb4a53e28c032edc8 552 Pfam PF03062 MBOAT, membrane-bound O-acyltransferase family 173 344 5.2E-18 T 21-04-2016 IPR004299 Membrane bound O-acyl transferase, MBOAT SPH21_RS16590 e9e23aed7391c9dcb4a53e28c032edc8 552 PANTHER PTHR13285:SF24 375 518 9.8E-86 T 21-04-2016 SPH21_RS16590 e9e23aed7391c9dcb4a53e28c032edc8 552 PANTHER PTHR13285:SF24 33 327 9.8E-86 T 21-04-2016 SPH21_RS16590 e9e23aed7391c9dcb4a53e28c032edc8 552 PIRSF PIRSF016636 365 552 1.1E-26 T 21-04-2016 IPR024194 Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB SPH21_RS16590 e9e23aed7391c9dcb4a53e28c032edc8 552 PIRSF PIRSF500217 27 552 4.7E-130 T 21-04-2016 IPR028362 Alginate O-acetyltransferase AlgI GO:0042121 KEGG: 00061+2.3.1.-|KEGG: 00253+2.3.1.-|KEGG: 00261+2.3.1.-|KEGG: 00310+2.3.1.-|KEGG: 00330+2.3.1.-|KEGG: 00332+2.3.1.-|KEGG: 00340+2.3.1.-|KEGG: 00350+2.3.1.-|KEGG: 00564+2.3.1.-|KEGG: 00565+2.3.1.-|KEGG: 00604+2.3.1.-|KEGG: 00623+2.3.1.-|KEGG: 00626+2.3.1.-|KEGG: 00627+2.3.1.-|KEGG: 00642+2.3.1.-|KEGG: 00650+2.3.1.-|KEGG: 00680+2.3.1.-|KEGG: 00903+2.3.1.-|KEGG: 00904+2.3.1.-|KEGG: 00906+2.3.1.-|KEGG: 00940+2.3.1.-|KEGG: 00942+2.3.1.-|KEGG: 00950+2.3.1.-|KEGG: 00960+2.3.1.-|KEGG: 00965+2.3.1.-|UniPathway: UPA00286 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 SUPERFAMILY SSF53649 391 436 7.12E-104 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 SUPERFAMILY SSF53649 28 353 7.12E-104 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 PANTHER PTHR10342 1 455 7.4E-113 T 21-04-2016 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 Pfam PF00884 Sulfatase 152 296 8.3E-23 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 Pfam PF00884 Sulfatase 29 135 8.5E-30 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 Gene3D G3DSA:3.40.720.10 149 344 6.5E-43 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 Gene3D G3DSA:3.40.720.10 28 134 1.5E-42 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 Gene3D G3DSA:3.30.1120.10 345 355 3.7E-10 T 21-04-2016 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 Gene3D G3DSA:3.30.1120.10 393 441 3.7E-10 T 21-04-2016 SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 ProSitePatterns PS00523 Sulfatases signature 1. 75 87 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS04625 641171ad57ec7a0259e1a14dbb04f61a 485 PANTHER PTHR10342:SF199 1 455 7.4E-113 T 21-04-2016 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 Gene3D G3DSA:1.10.287.130 304 363 4.4E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 422 532 1.7E-24 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 PANTHER PTHR24423 270 533 9.6E-65 T 21-04-2016 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 Pfam PF00512 His Kinase A (phospho-acceptor) domain 311 373 1.6E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 SUPERFAMILY SSF47384 297 375 9.42E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 SMART SM00387 421 533 1.1E-32 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 PRINTS PR00344 Bacterial sensor protein C-terminal signature 476 486 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 PRINTS PR00344 Bacterial sensor protein C-terminal signature 493 511 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 PRINTS PR00344 Bacterial sensor protein C-terminal signature 517 530 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 PRINTS PR00344 Bacterial sensor protein C-terminal signature 458 472 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 SMART SM00388 310 378 1.2E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 SUPERFAMILY SSF55874 367 531 1.44E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26365 b8e97a293a30a21f0647499d810f0dba 533 Gene3D G3DSA:3.30.565.10 364 531 1.1E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS12200 45a4140f82010c269de6004b23e57b9c 219 Gene3D G3DSA:1.10.357.10 6 175 3.6E-18 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS12200 45a4140f82010c269de6004b23e57b9c 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 43 66 1.2E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS12200 45a4140f82010c269de6004b23e57b9c 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 35 1.2E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS12200 45a4140f82010c269de6004b23e57b9c 219 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 66 1.6E-8 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS12200 45a4140f82010c269de6004b23e57b9c 219 SUPERFAMILY SSF46689 13 71 1.07E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22870 97f802866b917584ec8688f031cc9247 359 SUPERFAMILY SSF53686 22 328 1.7E-84 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS22870 97f802866b917584ec8688f031cc9247 359 PANTHER PTHR10314:SF8 26 325 9.0E-94 T 21-04-2016 SPH21_RS22870 97f802866b917584ec8688f031cc9247 359 Gene3D G3DSA:3.40.50.1100 61 162 4.1E-27 T 21-04-2016 SPH21_RS22870 97f802866b917584ec8688f031cc9247 359 PANTHER PTHR10314 26 325 9.0E-94 T 21-04-2016 SPH21_RS22870 97f802866b917584ec8688f031cc9247 359 Gene3D G3DSA:3.40.50.1100 168 328 2.1E-64 T 21-04-2016 SPH21_RS22870 97f802866b917584ec8688f031cc9247 359 Gene3D G3DSA:3.40.50.1100 21 60 2.1E-64 T 21-04-2016 SPH21_RS22870 97f802866b917584ec8688f031cc9247 359 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 27 315 6.7E-64 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Gene3D G3DSA:1.10.150.20 506 584 4.5E-23 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Pfam PF12826 Helix-hairpin-helix motif 513 569 2.6E-24 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Hamap MF_01588 DNA ligase [ligA]. 4 671 47.866 T 21-04-2016 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SUPERFAMILY SSF56091 3 315 1.92E-116 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Pfam PF01653 NAD-dependent DNA ligase adenylation domain 7 318 1.4E-124 T 21-04-2016 IPR013839 NAD-dependent DNA ligase, adenylation GO:0003911 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Pfam PF03120 NAD-dependent DNA ligase OB-fold domain 322 396 5.0E-33 T 21-04-2016 IPR004150 NAD-dependent DNA ligase, OB-fold GO:0003911|GO:0006260|GO:0006281 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Gene3D G3DSA:1.10.287.610 2 69 7.0E-25 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SMART SM00278 482 501 28.0 T 21-04-2016 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SMART SM00278 546 565 14.0 T 21-04-2016 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SMART SM00278 446 465 58.0 T 21-04-2016 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SMART SM00532 5 448 1.7E-247 T 21-04-2016 IPR013840 NAD-dependent DNA ligase, N-terminal GO:0003911 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 TIGRFAM TIGR00575 dnlj: DNA ligase, NAD-dependent 13 666 2.1E-248 T 21-04-2016 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SUPERFAMILY SSF50249 318 400 1.63E-24 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SUPERFAMILY SSF52113 595 672 2.04E-14 T 21-04-2016 IPR001357 BRCT domain SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Gene3D G3DSA:3.30.470.30 119 252 3.3E-44 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SUPERFAMILY SSF47781 404 579 1.71E-54 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Pfam PF03119 NAD-dependent DNA ligase C4 zinc finger domain 407 433 8.1E-10 T 21-04-2016 IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type GO:0003911|GO:0006260|GO:0006281 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 ProSitePatterns PS01056 NAD-dependent DNA ligase signature 2. 331 346 - T 21-04-2016 IPR033136 NAD-dependent DNA ligase, conserved site SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Pfam PF00533 BRCA1 C Terminus (BRCT) domain 596 671 7.8E-13 T 21-04-2016 IPR001357 BRCT domain SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Pfam PF14520 Helix-hairpin-helix domain 446 503 4.8E-4 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 PANTHER PTHR23389 1 534 9.6E-188 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Gene3D G3DSA:1.10.150.20 435 505 8.2E-24 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 SMART SM00292 596 672 2.8E-7 T 21-04-2016 IPR001357 BRCT domain SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Gene3D G3DSA:2.40.50.140 320 390 2.6E-30 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS00240 627469b39bbf396b73735a968befd622 672 ProSitePatterns PS01055 NAD-dependent DNA ligase signature 1. 115 144 - T 21-04-2016 IPR018239 NAD-dependent DNA ligase, active site SPH21_RS00240 627469b39bbf396b73735a968befd622 672 Gene3D G3DSA:3.40.50.10190 596 671 2.3E-18 T 21-04-2016 IPR001357 BRCT domain SPH21_RS00240 627469b39bbf396b73735a968befd622 672 PANTHER PTHR23389:SF9 1 534 9.6E-188 T 21-04-2016 SPH21_RS00240 627469b39bbf396b73735a968befd622 672 PIRSF PIRSF001604 1 672 8.8E-252 T 21-04-2016 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 SPH21_RS01565 0a210b7bd4286f441995e6a6695a491c 218 Hamap MF_00090 Protein-L-isoaspartate O-methyltransferase [pcm]. 10 218 34.371 T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS01565 0a210b7bd4286f441995e6a6695a491c 218 SUPERFAMILY SSF53335 22 214 1.93E-39 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS01565 0a210b7bd4286f441995e6a6695a491c 218 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 15 215 3.2E-53 T 21-04-2016 SPH21_RS01565 0a210b7bd4286f441995e6a6695a491c 218 ProSitePatterns PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 138 153 - T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS01565 0a210b7bd4286f441995e6a6695a491c 218 PANTHER PTHR11579 15 218 8.3E-60 T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS01565 0a210b7bd4286f441995e6a6695a491c 218 TIGRFAM TIGR00080 pimt: protein-L-isoaspartate O-methyltransferase 15 215 9.6E-53 T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS01565 0a210b7bd4286f441995e6a6695a491c 218 Gene3D G3DSA:3.40.50.150 21 215 5.4E-55 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS19025 537e830964086f56680b388425e08546 498 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 351 413 6.3E-13 T 21-04-2016 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SPH21_RS19025 537e830964086f56680b388425e08546 498 TIGRFAM TIGR02199 rfaE_dom_II: bifunctional protein RfaE, domain II 341 486 8.4E-56 T 21-04-2016 IPR011914 RfaE bifunctional protein, domain II GO:0005975|GO:0016773|GO:0016779 KEGG: 00040+2.7.1.16|KEGG: 00540+2.7.7.70+2.7.1.167|UniPathway: UPA00356|UniPathway: UPA00356 SPH21_RS19025 537e830964086f56680b388425e08546 498 SUPERFAMILY SSF53613 15 324 1.87E-40 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS19025 537e830964086f56680b388425e08546 498 PANTHER PTHR10584:SF159 1 352 1.6E-61 T 21-04-2016 SPH21_RS19025 537e830964086f56680b388425e08546 498 PANTHER PTHR10584 1 352 1.6E-61 T 21-04-2016 SPH21_RS19025 537e830964086f56680b388425e08546 498 Gene3D G3DSA:3.40.1190.20 16 320 1.6E-46 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS19025 537e830964086f56680b388425e08546 498 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 55 78 - T 21-04-2016 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SPH21_RS19025 537e830964086f56680b388425e08546 498 Gene3D G3DSA:3.40.50.620 349 474 8.0E-33 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS19025 537e830964086f56680b388425e08546 498 Pfam PF00294 pfkB family carbohydrate kinase 15 315 2.2E-29 T 21-04-2016 IPR011611 Carbohydrate kinase PfkB SPH21_RS19025 537e830964086f56680b388425e08546 498 Pfam PF01467 Cytidylyltransferase-like 354 451 2.0E-13 T 21-04-2016 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SPH21_RS19025 537e830964086f56680b388425e08546 498 SUPERFAMILY SSF52374 349 484 5.04E-24 T 21-04-2016 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SMART SM00388 829 894 1.2E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SUPERFAMILY SSF47384 817 895 1.24E-17 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 941 1055 3.9E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:2.120.10.30 480 538 5.2E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 1288 1330 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SUPERFAMILY SSF55874 883 1054 3.8E-38 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 525 547 8.6E-5 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 391 413 0.013 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 483 500 0.0062 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 344 367 1.8E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 439 458 1.8E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 252 274 0.016 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 21 43 8.2E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07494 Two component regulator propeller 568 589 0.011 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:1.10.10.60 1288 1336 9.1E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SMART SM00342 1251 1334 3.4E-25 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:3.30.565.10 880 1055 4.7E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SMART SM00448 1089 1201 2.0E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 PRINTS PR00344 Bacterial sensor protein C-terminal signature 999 1009 7.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 PRINTS PR00344 Bacterial sensor protein C-terminal signature 981 995 7.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1016 1034 7.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1040 1053 7.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SMART SM00387 940 1056 4.2E-31 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF07495 Y_Y_Y domain 712 774 6.1E-14 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:3.40.50.2300 1086 1216 2.5E-33 T 21-04-2016 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SUPERFAMILY SSF52172 1089 1214 1.99E-31 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:1.10.10.60 1230 1287 1.6E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 PANTHER PTHR24423 803 1243 9.0E-104 T 21-04-2016 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF12833 Helix-turn-helix domain 1257 1335 4.8E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF00072 Response regulator receiver domain 1091 1201 3.6E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Pfam PF00512 His Kinase A (phospho-acceptor) domain 830 893 5.6E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SUPERFAMILY SSF63829 256 371 3.6E-13 T 21-04-2016 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SUPERFAMILY SSF63829 25 186 3.6E-13 T 21-04-2016 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SUPERFAMILY SSF46689 1287 1336 2.82E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:2.120.10.30 375 464 6.8E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:2.120.10.30 266 374 1.3E-7 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:2.120.10.30 539 591 1.0E-7 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:2.120.10.30 18 174 1.2E-5 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 SUPERFAMILY SSF101898 354 592 5.49E-16 T 21-04-2016 SPH21_RS19480 cc669e5380f2ad3390772c65204f5a74 1337 Gene3D G3DSA:1.10.287.130 822 879 2.1E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS22485 653b87a6660a913203ffa2c43000f399 71 PANTHER PTHR36443 1 71 2.9E-15 T 21-04-2016 SPH21_RS22485 653b87a6660a913203ffa2c43000f399 71 PANTHER PTHR36443:SF1 1 71 2.9E-15 T 21-04-2016 SPH21_RS22485 653b87a6660a913203ffa2c43000f399 71 Pfam PF11146 Protein of unknown function (DUF2905) 2 65 9.5E-22 T 21-04-2016 IPR021320 Protein of unknown function DUF2905 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Pfam PF13715 CarboxypepD_reg-like domain 49 130 1.1E-17 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 236 266 8.7E-20 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Gene3D G3DSA:2.40.170.20 955 1036 2.5E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Gene3D G3DSA:2.40.170.20 864 920 2.5E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Gene3D G3DSA:2.40.170.20 262 280 2.5E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Gene3D G3DSA:2.40.170.20 344 796 2.5E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Gene3D G3DSA:2.170.130.10 133 261 9.2E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Gene3D G3DSA:2.60.40.1120 48 132 9.1E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 47 1037 1.8E-269 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532 580 1036 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532 227 389 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532 22 211 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532 461 549 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 Pfam PF07715 TonB-dependent Receptor Plug Domain 140 260 1.8E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532:SF57 580 1036 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532:SF57 227 389 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532:SF57 22 211 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 PANTHER PTHR11532:SF57 461 549 4.4E-245 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 SUPERFAMILY SSF49464 47 128 2.88E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 SUPERFAMILY SSF56935 126 284 1.69E-96 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 SUPERFAMILY SSF56935 451 796 1.69E-96 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 SUPERFAMILY SSF56935 335 423 1.69E-96 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 SUPERFAMILY SSF56935 945 1036 1.69E-96 T 21-04-2016 SPH21_RS01915 21f8486d42a3d2bb5b22978468bb5bbb 1038 SUPERFAMILY SSF56935 868 910 1.69E-96 T 21-04-2016 SPH21_RS01830 8165ffb915edca586b6187b38aacb612 243 Pfam PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 8 227 5.1E-21 T 21-04-2016 IPR006148 Glucosamine/galactosamine-6-phosphate isomerase GO:0005975 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906 SPH21_RS01830 8165ffb915edca586b6187b38aacb612 243 ProSitePatterns PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 117 135 - T 21-04-2016 IPR018321 Glucosamine-6-phosphate isomerase, conserved site GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|UniPathway: UPA00629 SPH21_RS01830 8165ffb915edca586b6187b38aacb612 243 PANTHER PTHR11280 1 242 4.4E-77 T 21-04-2016 IPR004547 Glucosamine-6-phosphate isomerase GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|UniPathway: UPA00629 SPH21_RS01830 8165ffb915edca586b6187b38aacb612 243 PANTHER PTHR11280:SF6 1 242 4.4E-77 T 21-04-2016 SPH21_RS01830 8165ffb915edca586b6187b38aacb612 243 SUPERFAMILY SSF100950 1 242 1.02E-60 T 21-04-2016 SPH21_RS01830 8165ffb915edca586b6187b38aacb612 243 Gene3D G3DSA:3.40.50.1360 1 243 8.1E-65 T 21-04-2016 SPH21_RS15635 29b75bd48dd30f1a37d48684e22da113 172 PANTHER PTHR21485 4 167 1.0E-43 T 21-04-2016 SPH21_RS15635 29b75bd48dd30f1a37d48684e22da113 172 Gene3D G3DSA:3.40.50.1000 3 165 5.1E-39 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS15635 29b75bd48dd30f1a37d48684e22da113 172 Pfam PF08282 haloacid dehalogenase-like hydrolase 84 152 2.5E-9 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS15635 29b75bd48dd30f1a37d48684e22da113 172 SUPERFAMILY SSF56784 5 164 1.58E-37 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS15635 29b75bd48dd30f1a37d48684e22da113 172 PANTHER PTHR21485:SF3 4 167 1.0E-43 T 21-04-2016 SPH21_RS15635 29b75bd48dd30f1a37d48684e22da113 172 PIRSF PIRSF006118 1 170 4.7E-58 T 21-04-2016 IPR010023 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase GO:0019143 KEGG: 00540+3.1.3.45|MetaCyc: PWY-1269|MetaCyc: PWY-7674|UniPathway: UPA00030|UniPathway: UPA00357 SPH21_RS15635 29b75bd48dd30f1a37d48684e22da113 172 TIGRFAM TIGR01670 KdsC-phosphatas: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family 11 160 2.4E-43 T 21-04-2016 IPR010023 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase GO:0019143 KEGG: 00540+3.1.3.45|MetaCyc: PWY-1269|MetaCyc: PWY-7674|UniPathway: UPA00030|UniPathway: UPA00357 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Gene3D G3DSA:2.60.40.1120 132 215 2.7E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Gene3D G3DSA:2.40.170.20 1042 1143 3.3E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Gene3D G3DSA:2.40.170.20 537 908 3.3E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Gene3D G3DSA:2.40.170.20 325 349 3.3E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Gene3D G3DSA:2.40.170.20 421 485 3.3E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Gene3D G3DSA:2.40.170.20 979 1004 3.3E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Pfam PF13715 CarboxypepD_reg-like domain 132 212 1.7E-16 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Pfam PF07715 TonB-dependent Receptor Plug Domain 220 325 1.5E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 SUPERFAMILY SSF49464 130 210 2.75E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 131 1143 4.1E-278 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 SUPERFAMILY SSF56935 208 349 3.11E-96 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 SUPERFAMILY SSF56935 555 899 3.11E-96 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 SUPERFAMILY SSF56935 971 1014 3.11E-96 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 SUPERFAMILY SSF56935 412 500 3.11E-96 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 SUPERFAMILY SSF56935 1052 1143 3.11E-96 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532:SF57 684 1141 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532:SF57 529 561 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532:SF57 127 466 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532:SF57 628 654 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Pfam PF07660 Secretin and TonB N terminus short domain 65 116 1.1E-8 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Gene3D G3DSA:2.170.130.10 216 324 2.6E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 Pfam PF00593 TonB dependent receptor 731 1141 7.7E-22 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532 684 1141 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532 529 561 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532 127 466 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 PANTHER PTHR11532 628 654 1.6E-262 T 21-04-2016 SPH21_RS08220 00f1bf4576412681c5105257a9a4db55 1143 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 301 330 1.1E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS26085 b441578fc66063bd97211e6d1775e214 396 PANTHER PTHR30273 1 122 1.6E-51 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26085 b441578fc66063bd97211e6d1775e214 396 PANTHER PTHR30273 191 396 1.6E-51 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26085 b441578fc66063bd97211e6d1775e214 396 PANTHER PTHR30273:SF2 1 122 1.6E-51 T 21-04-2016 SPH21_RS26085 b441578fc66063bd97211e6d1775e214 396 PANTHER PTHR30273:SF2 191 396 1.6E-51 T 21-04-2016 SPH21_RS26085 b441578fc66063bd97211e6d1775e214 396 Pfam PF16344 Domain of unknown function (DUF4974) 308 392 9.5E-17 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS26085 b441578fc66063bd97211e6d1775e214 396 Pfam PF04773 FecR protein 189 283 2.4E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 SUPERFAMILY SSF52096 6 314 8.24E-98 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 TIGRFAM TIGR00513 accA: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit 3 316 9.0E-140 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PANTHER PTHR22855:SF42 2 317 8.2E-120 T 21-04-2016 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 Gene3D G3DSA:3.90.226.10 54 270 1.9E-51 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PRINTS PR01069 Acetyl-CoA carboxylase carboxyl transferase alpha subunit signature 87 98 3.8E-44 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PRINTS PR01069 Acetyl-CoA carboxylase carboxyl transferase alpha subunit signature 196 205 3.8E-44 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PRINTS PR01069 Acetyl-CoA carboxylase carboxyl transferase alpha subunit signature 152 165 3.8E-44 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PRINTS PR01069 Acetyl-CoA carboxylase carboxyl transferase alpha subunit signature 168 181 3.8E-44 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PRINTS PR01069 Acetyl-CoA carboxylase carboxyl transferase alpha subunit signature 133 149 3.8E-44 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PRINTS PR01069 Acetyl-CoA carboxylase carboxyl transferase alpha subunit signature 112 130 3.8E-44 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 Hamap MF_00823 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [accA]. 4 315 47.916 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 Pfam PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit 5 147 9.3E-65 T 21-04-2016 IPR001095 Acetyl-CoA carboxylase, alpha subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS11015 4152bf461c4f9d542d7253eb165da231 317 PANTHER PTHR22855 2 317 8.2E-120 T 21-04-2016 SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 SMART SM00448 9 126 3.5E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 Pfam PF00072 Response regulator receiver domain 11 125 9.1E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 Gene3D G3DSA:1.20.120.160 168 263 2.7E-15 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 SUPERFAMILY SSF47226 156 255 1.01E-14 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 SUPERFAMILY SSF47226 109 122 1.01E-14 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 Gene3D G3DSA:3.40.50.2300 3 132 7.7E-27 T 21-04-2016 SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 SUPERFAMILY SSF52172 8 129 2.56E-26 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20070 6153932b3b2009f9ccf55ed556f4ee5d 264 PANTHER PTHR24423 9 168 2.1E-29 T 21-04-2016 SPH21_RS22875 0139e66afcc73c6e242c314413e87eab 364 PANTHER PTHR30298 1 364 1.5E-111 T 21-04-2016 SPH21_RS22875 0139e66afcc73c6e242c314413e87eab 364 Pfam PF13808 DDE_Tnp_1-associated 5 92 1.4E-34 T 21-04-2016 IPR032806 H repeat-associated protein, N-terminal SPH21_RS22875 0139e66afcc73c6e242c314413e87eab 364 Pfam PF01609 Transposase DDE domain 101 333 4.2E-27 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS21825 0139e66afcc73c6e242c314413e87eab 364 PANTHER PTHR30298 1 364 1.5E-111 T 21-04-2016 SPH21_RS21825 0139e66afcc73c6e242c314413e87eab 364 Pfam PF13808 DDE_Tnp_1-associated 5 92 1.4E-34 T 21-04-2016 IPR032806 H repeat-associated protein, N-terminal SPH21_RS21825 0139e66afcc73c6e242c314413e87eab 364 Pfam PF01609 Transposase DDE domain 101 333 4.2E-27 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS04665 0139e66afcc73c6e242c314413e87eab 364 PANTHER PTHR30298 1 364 1.5E-111 T 21-04-2016 SPH21_RS04665 0139e66afcc73c6e242c314413e87eab 364 Pfam PF13808 DDE_Tnp_1-associated 5 92 1.4E-34 T 21-04-2016 IPR032806 H repeat-associated protein, N-terminal SPH21_RS04665 0139e66afcc73c6e242c314413e87eab 364 Pfam PF01609 Transposase DDE domain 101 333 4.2E-27 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS22070 383895783d697e704672514ef7b36f05 501 Gene3D G3DSA:2.115.10.20 40 352 2.7E-86 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS22070 383895783d697e704672514ef7b36f05 501 Gene3D G3DSA:2.60.120.260 367 497 1.2E-23 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22070 383895783d697e704672514ef7b36f05 501 SUPERFAMILY SSF49785 367 496 4.96E-23 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22070 383895783d697e704672514ef7b36f05 501 PANTHER PTHR22925:SF12 42 470 4.5E-107 T 21-04-2016 SPH21_RS22070 383895783d697e704672514ef7b36f05 501 SUPERFAMILY SSF75005 12 336 9.03E-62 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS22070 383895783d697e704672514ef7b36f05 501 Pfam PF04616 Glycosyl hydrolases family 43 43 335 6.5E-54 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS22070 383895783d697e704672514ef7b36f05 501 Pfam PF00754 F5/8 type C domain 369 487 1.2E-15 T 21-04-2016 IPR000421 Coagulation factor 5/8 C-terminal domain SPH21_RS22070 383895783d697e704672514ef7b36f05 501 PANTHER PTHR22925 42 470 4.5E-107 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS21640 1cdf2e18b433d1f553ae423510116066 208 Gene3D G3DSA:3.20.80.10 1 204 1.5E-38 T 21-04-2016 IPR011256 Regulatory factor, effector binding domain SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 Gene3D G3DSA:3.50.50.60 362 419 6.1E-52 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 Gene3D G3DSA:3.50.50.60 113 135 6.1E-52 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 Gene3D G3DSA:3.50.50.60 7 63 6.1E-52 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 Gene3D G3DSA:3.50.50.60 193 271 6.1E-52 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 Pfam PF01266 FAD dependent oxidoreductase 9 401 7.3E-57 T 21-04-2016 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 SUPERFAMILY SSF54373 272 362 2.49E-11 T 21-04-2016 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 Gene3D G3DSA:3.30.9.10 140 192 5.8E-7 T 21-04-2016 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 Gene3D G3DSA:3.30.9.10 272 315 5.8E-7 T 21-04-2016 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 PANTHER PTHR13847 9 65 2.4E-55 T 21-04-2016 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 PANTHER PTHR13847 112 419 2.4E-55 T 21-04-2016 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 SUPERFAMILY SSF51905 9 67 2.07E-46 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 SUPERFAMILY SSF51905 362 419 2.07E-46 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04845 5997613884b08e2c75152a7115aada4f 420 SUPERFAMILY SSF51905 120 272 2.07E-46 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS02680 3730b032db6d53faf3e0ce81393e99ab 165 Pfam PF00583 Acetyltransferase (GNAT) family 59 137 7.7E-13 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS02680 3730b032db6d53faf3e0ce81393e99ab 165 SUPERFAMILY SSF55729 1 160 1.8E-28 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS02680 3730b032db6d53faf3e0ce81393e99ab 165 Gene3D G3DSA:3.40.630.30 1 160 6.4E-31 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS02680 3730b032db6d53faf3e0ce81393e99ab 165 PANTHER PTHR13947 1 160 1.5E-24 T 21-04-2016 SPH21_RS02680 3730b032db6d53faf3e0ce81393e99ab 165 PANTHER PTHR13947:SF7 1 160 1.5E-24 T 21-04-2016 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 PANTHER PTHR12128 3 309 1.3E-101 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 PANTHER PTHR12128:SF30 3 309 1.3E-101 T 21-04-2016 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 Pfam PF00701 Dihydrodipicolinate synthetase family 4 291 1.5E-53 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 SMART SM01130 3 295 2.2E-62 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 Gene3D G3DSA:3.20.20.70 1 292 2.5E-74 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 PIRSF PIRSF001365 1 303 2.5E-64 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 PRINTS PR00146 Dihydrodipicolinate synthase signature 37 58 8.9E-10 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 PRINTS PR00146 Dihydrodipicolinate synthase signature 73 91 8.9E-10 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 PRINTS PR00146 Dihydrodipicolinate synthase signature 132 149 8.9E-10 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS22645 66a96055ecf00535f43142507ded8946 311 SUPERFAMILY SSF51569 2 292 3.98E-71 T 21-04-2016 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 PANTHER PTHR30173:SF20 21 184 5.6E-37 T 21-04-2016 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 Gene3D G3DSA:1.10.1740.10 19 120 4.0E-14 T 21-04-2016 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 Pfam PF08281 Sigma-70, region 4 128 177 3.0E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 25 180 6.4E-24 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 PANTHER PTHR30173 21 184 5.6E-37 T 21-04-2016 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 SUPERFAMILY SSF88659 103 189 3.92E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 Gene3D G3DSA:1.10.10.10 121 183 6.9E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 Pfam PF04542 Sigma-70 region 2 28 92 6.0E-8 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 SUPERFAMILY SSF88946 16 110 4.32E-15 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 23 180 4.5E-41 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 ProSitePatterns PS00622 LuxR-type HTH domain signature. 149 176 - T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 149 165 1.8E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS26180 5696b2717e3f2e05ff20fc6069db9ad4 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 177 1.8E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004 5 84 3.0E-69 T 21-04-2016 SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004 102 459 3.0E-69 T 21-04-2016 SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 Gene3D G3DSA:1.10.10.10 12 42 2.6E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 Gene3D G3DSA:3.30.420.10 167 296 5.0E-10 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 Pfam PF00665 Integrase core domain 139 265 6.1E-16 T 21-04-2016 IPR001584 Integrase, catalytic core GO:0015074 SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 SUPERFAMILY SSF53098 167 297 5.31E-11 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004:SF2 5 84 3.0E-69 T 21-04-2016 SPH21_RS24365 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004:SF2 102 459 3.0E-69 T 21-04-2016 SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004 5 84 3.0E-69 T 21-04-2016 SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004 102 459 3.0E-69 T 21-04-2016 SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 Gene3D G3DSA:1.10.10.10 12 42 2.6E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 Gene3D G3DSA:3.30.420.10 167 296 5.0E-10 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 Pfam PF00665 Integrase core domain 139 265 6.1E-16 T 21-04-2016 IPR001584 Integrase, catalytic core GO:0015074 SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 SUPERFAMILY SSF53098 167 297 5.31E-11 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004:SF2 5 84 3.0E-69 T 21-04-2016 SPH21_RS04190 2d64305994bec743bc6a07021425c8d9 517 PANTHER PTHR35004:SF2 102 459 3.0E-69 T 21-04-2016 SPH21_RS11635 386d2eef27726acd65f3842d5703e647 476 SUPERFAMILY SSF51445 80 416 1.05E-80 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS11635 386d2eef27726acd65f3842d5703e647 476 PANTHER PTHR11069 38 476 1.9E-116 T 21-04-2016 IPR001139 Glycoside hydrolase family 30 GO:0004348|GO:0006665 SPH21_RS11635 386d2eef27726acd65f3842d5703e647 476 Gene3D G3DSA:3.20.20.80 58 409 5.9E-126 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11635 386d2eef27726acd65f3842d5703e647 476 Pfam PF17189 Glycosyl hydrolase family 30 beta sandwich domain 415 474 4.4E-11 T 21-04-2016 IPR033452 Glycosyl hydrolase family 30, beta sandwich domain SPH21_RS11635 386d2eef27726acd65f3842d5703e647 476 Gene3D G3DSA:2.60.40.1180 410 461 7.0E-11 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS11635 386d2eef27726acd65f3842d5703e647 476 Pfam PF02055 Glycosyl hydrolase family 30 TIM-barrel domain 80 412 7.1E-48 T 21-04-2016 IPR033453 Glycosyl hydrolase family 30, TIM-barrel domain SPH21_RS05940 87eae6d1a0f88d0c1d9a47355705c464 97 PANTHER PTHR33571 6 95 1.4E-27 T 21-04-2016 SPH21_RS05940 87eae6d1a0f88d0c1d9a47355705c464 97 Gene3D G3DSA:3.30.460.10 3 93 1.0E-26 T 21-04-2016 SPH21_RS05940 87eae6d1a0f88d0c1d9a47355705c464 97 SUPERFAMILY SSF81301 4 89 1.29E-22 T 21-04-2016 SPH21_RS05940 87eae6d1a0f88d0c1d9a47355705c464 97 Pfam PF01909 Nucleotidyltransferase domain 15 89 6.7E-14 T 21-04-2016 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 Gene3D G3DSA:3.40.50.620 1 145 3.8E-18 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 SUPERFAMILY SSF52402 165 274 3.68E-10 T 21-04-2016 SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 PRINTS PR01438 Universal stress protein signature 1 18 1.9E-11 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 PRINTS PR01438 Universal stress protein signature 104 116 1.9E-11 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 PRINTS PR01438 Universal stress protein signature 122 144 1.9E-11 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 Gene3D G3DSA:3.40.50.620 213 275 1.7E-6 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 SUPERFAMILY SSF52402 1 153 2.93E-18 T 21-04-2016 SPH21_RS01810 b37c54f898b93c7358d4b4f1695c997c 278 Pfam PF00582 Universal stress protein family 2 144 8.5E-16 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS11360 6af3564000c516bb6d1b03d549e76ed1 223 Pfam PF12875 Protein of unknown function (DUF3826) 35 215 3.4E-68 T 21-04-2016 IPR024284 Protein of unknown function DUF3826 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 Gene3D G3DSA:3.30.565.10 261 431 2.6E-36 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 PRINTS PR00344 Bacterial sensor protein C-terminal signature 359 373 5.6E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 PRINTS PR00344 Bacterial sensor protein C-terminal signature 416 429 5.6E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 PRINTS PR00344 Bacterial sensor protein C-terminal signature 377 387 5.6E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 PRINTS PR00344 Bacterial sensor protein C-terminal signature 392 410 5.6E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 Pfam PF00512 His Kinase A (phospho-acceptor) domain 209 271 2.9E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 SUPERFAMILY SSF47384 192 274 6.28E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 SUPERFAMILY SSF158472 156 205 3.14E-7 T 21-04-2016 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 SUPERFAMILY SSF55874 264 430 3.01E-33 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 Gene3D G3DSA:1.10.287.130 198 260 2.5E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 PANTHER PTHR24423 148 429 1.5E-56 T 21-04-2016 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 PANTHER PTHR24423 82 92 1.5E-56 T 21-04-2016 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 SMART SM00304 154 207 1.9E-8 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 SMART SM00387 323 432 1.8E-27 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 325 429 2.9E-20 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 Pfam PF00672 HAMP domain 134 203 5.5E-10 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS19735 c537deef2d6199b566e1f7f7826ec613 435 SMART SM00388 208 274 3.5E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 TIGRFAM TIGR03303 OM_YaeT: outer membrane protein assembly complex, YaeT protein 43 847 8.1E-96 T 21-04-2016 IPR023707 Outer membrane protein assembly factor BamA GO:0071709 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 Pfam PF01103 Surface antigen 495 847 1.2E-29 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 Pfam PF07244 Surface antigen variable number repeat 289 369 4.5E-10 T 21-04-2016 IPR010827 Surface antigen variable number GO:0019867 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 Pfam PF07244 Surface antigen variable number repeat 200 286 1.3E-9 T 21-04-2016 IPR010827 Surface antigen variable number GO:0019867 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 Pfam PF07244 Surface antigen variable number repeat 118 194 1.7E-8 T 21-04-2016 IPR010827 Surface antigen variable number GO:0019867 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 Pfam PF07244 Surface antigen variable number repeat 376 450 1.8E-8 T 21-04-2016 IPR010827 Surface antigen variable number GO:0019867 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 PANTHER PTHR12815 494 645 1.1E-109 T 21-04-2016 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 PANTHER PTHR12815 662 851 1.1E-109 T 21-04-2016 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 PANTHER PTHR12815 41 478 1.1E-109 T 21-04-2016 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 PANTHER PTHR12815:SF11 494 645 1.1E-109 T 21-04-2016 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 PANTHER PTHR12815:SF11 662 851 1.1E-109 T 21-04-2016 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 PANTHER PTHR12815:SF11 41 478 1.1E-109 T 21-04-2016 SPH21_RS25605 a6edac5f0f839cccdfc5daccdf49c6e0 855 PIRSF PIRSF006076 2 851 9.7E-164 T 21-04-2016 IPR023707 Outer membrane protein assembly factor BamA GO:0071709 SPH21_RS23195 2a58d194a1c8ba0ca69502d37ae37fa6 217 Pfam PF07081 Protein of unknown function (DUF1349) 27 201 1.9E-61 T 21-04-2016 IPR009784 Protein of unknown function DUF1349 SPH21_RS23195 2a58d194a1c8ba0ca69502d37ae37fa6 217 PANTHER PTHR35332:SF2 19 210 8.5E-63 T 21-04-2016 SPH21_RS23195 2a58d194a1c8ba0ca69502d37ae37fa6 217 PANTHER PTHR35332 19 210 8.5E-63 T 21-04-2016 SPH21_RS23195 2a58d194a1c8ba0ca69502d37ae37fa6 217 Gene3D G3DSA:2.60.120.200 27 200 5.8E-19 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS23195 2a58d194a1c8ba0ca69502d37ae37fa6 217 PIRSF PIRSF022704 15 211 1.1E-71 T 21-04-2016 IPR015987 Uncharacterised conserved protein UCP022704 SPH21_RS23195 2a58d194a1c8ba0ca69502d37ae37fa6 217 SUPERFAMILY SSF49899 26 201 3.68E-24 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS07920 a44c0401dfaacc1154f0bccb07735858 459 Pfam PF00361 Proton-conducting membrane transporter 114 406 5.3E-70 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS07920 a44c0401dfaacc1154f0bccb07735858 459 PANTHER PTHR22773 4 459 6.5E-141 T 21-04-2016 SPH21_RS07920 a44c0401dfaacc1154f0bccb07735858 459 PANTHER PTHR22773:SF41 4 459 6.5E-141 T 21-04-2016 SPH21_RS07920 a44c0401dfaacc1154f0bccb07735858 459 Hamap MF_00445 NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic [ndhB]. 1 456 16.806 T 21-04-2016 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 SPH21_RS07920 a44c0401dfaacc1154f0bccb07735858 459 TIGRFAM TIGR01770 NDH_I_N: proton-translocating NADH-quinone oxidoreductase, chain N 7 454 2.9E-120 T 21-04-2016 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 SPH21_RS23800 3dd153af04ebcaca18b5c6cdb8e2a47a 280 Pfam PF03640 Secreted repeat of unknown function 233 269 4.5E-9 T 21-04-2016 IPR005297 Lipoprotein repeat SPH21_RS23800 3dd153af04ebcaca18b5c6cdb8e2a47a 280 Pfam PF03640 Secreted repeat of unknown function 99 141 1.6E-11 T 21-04-2016 IPR005297 Lipoprotein repeat SPH21_RS23800 3dd153af04ebcaca18b5c6cdb8e2a47a 280 Pfam PF03640 Secreted repeat of unknown function 44 80 6.6E-8 T 21-04-2016 IPR005297 Lipoprotein repeat SPH21_RS23800 3dd153af04ebcaca18b5c6cdb8e2a47a 280 PANTHER PTHR39335 39 261 2.6E-23 T 21-04-2016 SPH21_RS26195 2e9d77127bbfb86abf2363cbc603b424 471 PANTHER PTHR30576:SF0 13 471 2.4E-116 T 21-04-2016 SPH21_RS26195 2e9d77127bbfb86abf2363cbc603b424 471 TIGRFAM TIGR03025 EPS_sugtrans: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase 16 470 3.2E-121 T 21-04-2016 IPR017475 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase SPH21_RS26195 2e9d77127bbfb86abf2363cbc603b424 471 Pfam PF13727 CoA-binding domain 64 170 1.4E-9 T 21-04-2016 SPH21_RS26195 2e9d77127bbfb86abf2363cbc603b424 471 TIGRFAM TIGR03023 WcaJ_sugtrans: undecaprenyl-phosphate glucose phosphotransferase 16 471 1.1E-125 T 21-04-2016 IPR017473 Undecaprenyl-phosphate glucose phosphotransferase, WcaJ MetaCyc: PWY-6655|MetaCyc: PWY-6658 SPH21_RS26195 2e9d77127bbfb86abf2363cbc603b424 471 Pfam PF02397 Bacterial sugar transferase 275 464 3.5E-57 T 21-04-2016 IPR003362 Bacterial sugar transferase SPH21_RS26195 2e9d77127bbfb86abf2363cbc603b424 471 PANTHER PTHR30576 13 471 2.4E-116 T 21-04-2016 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 Gene3D G3DSA:2.60.40.1120 441 502 1.1E-4 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 SUPERFAMILY SSF82171 191 373 4.97E-7 T 21-04-2016 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 PRINTS PR01021 OMPA domain signature 584 600 5.5E-13 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 PRINTS PR01021 OMPA domain signature 539 561 5.5E-13 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 PRINTS PR01021 OMPA domain signature 569 584 5.5E-13 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 SUPERFAMILY SSF48452 27 121 7.17E-12 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 SUPERFAMILY SSF103088 527 644 6.41E-31 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 Gene3D G3DSA:2.120.10.30 221 361 2.5E-5 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 PANTHER PTHR30128 532 647 5.0E-38 T 21-04-2016 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 Gene3D G3DSA:3.30.1330.60 530 645 3.4E-36 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 Pfam PF00691 OmpA family 538 626 3.1E-18 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 Gene3D G3DSA:1.25.40.10 26 121 1.5E-12 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 Pfam PF07676 WD40-like Beta Propeller Repeat 336 361 0.1 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS10315 32b9db26f383b0c554af7261e359eb79 647 Pfam PF07676 WD40-like Beta Propeller Repeat 295 319 0.022 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Pfam PF03144 Elongation factor Tu domain 2 326 393 2.0E-15 T 21-04-2016 IPR004161 Translation elongation factor EFTu/EF1A, domain 2 GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Pfam PF03764 Elongation factor G, domain IV 481 602 3.9E-40 T 21-04-2016 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Pfam PF14492 Elongation Factor G, domain II 406 478 6.8E-32 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Hamap MF_00054_B Elongation factor G [fusA]. 4 696 103.203 T 21-04-2016 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Gene3D G3DSA:3.30.230.10 486 604 1.0E-41 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Gene3D G3DSA:2.40.30.10 308 407 7.2E-38 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 SUPERFAMILY SSF50447 267 406 7.57E-35 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 8 182 1.4E-32 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Gene3D G3DSA:3.40.50.300 3 289 4.6E-95 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Gene3D G3DSA:3.30.70.870 408 482 7.6E-36 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 SUPERFAMILY SSF54980 406 483 2.01E-24 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 49 64 - T 21-04-2016 IPR031157 Tr-type G domain, conserved site SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 SUPERFAMILY SSF54980 608 695 1.68E-31 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PANTHER PTHR23115 1 179 0.0 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PANTHER PTHR23115 305 696 0.0 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PANTHER PTHR23115 257 285 0.0 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PANTHER PTHR23115:SF66 1 179 0.0 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PANTHER PTHR23115:SF66 305 696 0.0 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PANTHER PTHR23115:SF66 257 285 0.0 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Pfam PF00009 Elongation factor Tu GTP binding domain 8 284 7.8E-63 T 21-04-2016 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 SMART SM00889 482 603 3.5E-57 T 21-04-2016 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 SUPERFAMILY SSF52540 4 284 1.85E-96 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 SMART SM00838 605 692 2.0E-51 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 TIGRFAM TIGR00484 EF-G: translation elongation factor G 4 697 0.0 T 21-04-2016 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Gene3D G3DSA:3.30.70.240 605 690 3.9E-34 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 Pfam PF00679 Elongation factor G C-terminus 605 691 3.1E-31 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 SUPERFAMILY SSF54211 481 604 1.64E-37 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PRINTS PR00315 GTP-binding elongation factor signature 132 141 4.6E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PRINTS PR00315 GTP-binding elongation factor signature 10 23 4.6E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PRINTS PR00315 GTP-binding elongation factor signature 80 90 4.6E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PRINTS PR00315 GTP-binding elongation factor signature 56 64 4.6E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS19750 6b3f500e31445437cf720a6b3c3587f5 702 PRINTS PR00315 GTP-binding elongation factor signature 96 107 4.6E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS22910 ec264ce90eecba107b505523822381ec 293 SUPERFAMILY SSF50956 39 192 4.18E-8 T 21-04-2016 SPH21_RS22910 ec264ce90eecba107b505523822381ec 293 Gene3D G3DSA:2.130.10.10 149 273 1.5E-6 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS22910 ec264ce90eecba107b505523822381ec 293 SUPERFAMILY SSF50969 149 273 6.67E-6 T 21-04-2016 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 PANTHER PTHR23514:SF7 17 266 7.3E-114 T 21-04-2016 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 PANTHER PTHR23514:SF7 289 430 7.3E-114 T 21-04-2016 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 TIGRFAM TIGR00885 fucP: L-fucose:H+ symporter permease 18 428 1.5E-100 T 21-04-2016 IPR005275 L-fucose permease FucP GO:0015150|GO:0015756 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 Gene3D G3DSA:1.20.1250.20 23 224 8.2E-23 T 21-04-2016 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 PANTHER PTHR23514 17 266 7.3E-114 T 21-04-2016 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 PANTHER PTHR23514 289 430 7.3E-114 T 21-04-2016 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 Gene3D G3DSA:1.20.1250.20 230 430 7.4E-5 T 21-04-2016 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 Pfam PF07690 Major Facilitator Superfamily 45 391 4.7E-19 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS03040 d0abf70d77a8cdb0ca5de869f629e1db 446 SUPERFAMILY SSF103473 18 431 2.75E-37 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 PANTHER PTHR10887:SF340 840 1200 1.1E-49 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 PANTHER PTHR10887:SF340 291 374 1.1E-49 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 PANTHER PTHR10887:SF340 28 86 1.1E-49 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Pfam PF11784 Protein of unknown function (DUF3320) 1393 1439 3.7E-15 T 21-04-2016 IPR021754 Protein of unknown function DUF3320 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Gene3D G3DSA:3.40.960.10 1293 1342 6.4E-4 T 21-04-2016 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Pfam PF13086 AAA domain 941 981 4.2E-8 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Gene3D G3DSA:3.40.50.300 941 1045 2.3E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Gene3D G3DSA:3.40.50.300 273 401 2.3E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 SUPERFAMILY SSF52540 800 828 3.62E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 SUPERFAMILY SSF52540 913 1223 3.62E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 SUPERFAMILY SSF52540 1008 1043 1.65E-25 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 SUPERFAMILY SSF52540 290 372 1.65E-25 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 SUPERFAMILY SSF52540 929 980 1.65E-25 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Pfam PF13245 Part of AAA domain 308 362 1.9E-8 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Pfam PF13087 AAA domain 1012 1197 2.7E-12 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 PANTHER PTHR10887 840 1200 1.1E-49 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 PANTHER PTHR10887 291 374 1.1E-49 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 PANTHER PTHR10887 28 86 1.1E-49 T 21-04-2016 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 Pfam PF13195 Protein of unknown function (DUF4011) 16 182 4.2E-43 T 21-04-2016 IPR025103 Protein of unknown function DUF4011 SPH21_RS21160 c93a2c3c20ca2f43314bf0e17d4db4f1 1556 SUPERFAMILY SSF52980 1239 1342 1.23E-13 T 21-04-2016 IPR011335 Restriction endonuclease type II-like SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 226 241 1.3E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 241 257 1.3E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 SMART SM00342 173 257 4.4E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 SUPERFAMILY SSF46689 214 260 1.48E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 Gene3D G3DSA:1.10.10.60 212 259 4.8E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 PANTHER PTHR11019 21 261 3.2E-29 T 21-04-2016 SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 PANTHER PTHR11019:SF45 21 261 3.2E-29 T 21-04-2016 SPH21_RS21975 0a297ff66427f0a6fe7664275adff66d 262 Pfam PF12833 Helix-turn-helix domain 179 258 5.0E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS06495 8dbd856ba3a46db6faee5d94a592ae64 137 PIRSF PIRSF006113 1 137 2.1E-18 T 21-04-2016 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein SPH21_RS06495 8dbd856ba3a46db6faee5d94a592ae64 137 Pfam PF01242 6-pyruvoyl tetrahydropterin synthase 3 135 1.3E-31 T 21-04-2016 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein SPH21_RS06495 8dbd856ba3a46db6faee5d94a592ae64 137 PANTHER PTHR12589 1 136 1.3E-46 T 21-04-2016 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein SPH21_RS06495 8dbd856ba3a46db6faee5d94a592ae64 137 Gene3D G3DSA:3.30.479.10 1 136 2.3E-42 T 21-04-2016 SPH21_RS06495 8dbd856ba3a46db6faee5d94a592ae64 137 SUPERFAMILY SSF55620 1 136 4.95E-41 T 21-04-2016 SPH21_RS06495 8dbd856ba3a46db6faee5d94a592ae64 137 PANTHER PTHR12589:SF1 1 136 1.3E-46 T 21-04-2016 SPH21_RS03160 37428d7b75f5997f0ec2faad8e25f108 544 SUPERFAMILY SSF48452 17 544 1.71E-83 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03160 37428d7b75f5997f0ec2faad8e25f108 544 Pfam PF14322 Starch-binding associating with outer membrane 75 217 1.7E-26 T 21-04-2016 SPH21_RS03160 37428d7b75f5997f0ec2faad8e25f108 544 Pfam PF07980 SusD family 258 544 2.9E-25 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS03160 37428d7b75f5997f0ec2faad8e25f108 544 Gene3D G3DSA:1.25.40.10 395 483 1.1E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03160 37428d7b75f5997f0ec2faad8e25f108 544 Gene3D G3DSA:1.25.40.10 197 303 1.1E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02485 d012d0ee82c7b32fb64c1696fd8819e6 493 Pfam PF12771 Starch-binding associating with outer membrane 11 486 1.9E-47 T 21-04-2016 SPH21_RS02485 d012d0ee82c7b32fb64c1696fd8819e6 493 SUPERFAMILY SSF48452 22 488 7.21E-101 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02485 d012d0ee82c7b32fb64c1696fd8819e6 493 PANTHER PTHR35148 3 493 3.4E-42 T 21-04-2016 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PANTHER PTHR11482 5 390 1.8E-126 T 21-04-2016 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 SUPERFAMILY SSF50621 242 388 7.74E-39 T 21-04-2016 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 SUPERFAMILY SSF51419 14 273 5.23E-67 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 ProSitePatterns PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 45 63 - T 21-04-2016 IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 39 273 2.1E-55 T 21-04-2016 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 TIGRFAM TIGR01048 lysA: diaminopimelate decarboxylase 8 387 4.2E-117 T 21-04-2016 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 277 387 3.9E-20 T 21-04-2016 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 45 63 1.3E-20 T 21-04-2016 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 65 77 1.3E-20 T 21-04-2016 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 262 281 1.3E-20 T 21-04-2016 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 178 191 1.3E-20 T 21-04-2016 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 367 380 1.3E-20 T 21-04-2016 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 Hamap MF_02120 Diaminopimelate decarboxylase [lysA]. 3 391 32.865 T 21-04-2016 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 Gene3D G3DSA:2.40.37.10 263 388 1.5E-39 T 21-04-2016 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01181 Diaminopimelate decarboxylase signature 290 308 9.4E-15 T 21-04-2016 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01181 Diaminopimelate decarboxylase signature 152 161 9.4E-15 T 21-04-2016 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PRINTS PR01181 Diaminopimelate decarboxylase signature 63 80 9.4E-15 T 21-04-2016 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 ProSitePatterns PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 216 229 - T 21-04-2016 IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site Reactome: REACT_13 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 PANTHER PTHR11482:SF5 5 390 1.8E-126 T 21-04-2016 SPH21_RS15795 dc2f93a6226a1be57d77eb63ec41fccc 392 Gene3D G3DSA:3.20.20.10 33 262 3.7E-68 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 SUPERFAMILY SSF48173 206 425 1.83E-52 T 21-04-2016 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 PANTHER PTHR11455 2 425 8.9E-126 T 21-04-2016 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 Pfam PF03441 FAD binding domain of DNA photolyase 282 425 2.0E-33 T 21-04-2016 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 PRINTS PR00147 DNA photolyase signature 388 402 5.0E-7 T 21-04-2016 IPR002081 Cryptochrome/DNA photolyase class 1 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 PRINTS PR00147 DNA photolyase signature 329 345 5.0E-7 T 21-04-2016 IPR002081 Cryptochrome/DNA photolyase class 1 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 PRINTS PR00147 DNA photolyase signature 349 367 5.0E-7 T 21-04-2016 IPR002081 Cryptochrome/DNA photolyase class 1 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 Gene3D G3DSA:3.40.50.620 2 150 3.2E-46 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 Gene3D G3DSA:1.10.579.10 290 425 2.2E-39 T 21-04-2016 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 TIGRFAM TIGR02765 crypto_DASH: cryptochrome, DASH family 5 425 2.7E-120 T 21-04-2016 IPR014133 Cryptochrome DASH GO:0003913|GO:0006281 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 Pfam PF00875 DNA photolyase 7 170 3.6E-38 T 21-04-2016 IPR006050 DNA photolyase, N-terminal SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 PANTHER PTHR11455:SF22 2 425 8.9E-126 T 21-04-2016 IPR014133 Cryptochrome DASH GO:0003913|GO:0006281 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 Gene3D G3DSA:1.25.40.80 151 289 4.7E-40 T 21-04-2016 SPH21_RS08330 9165e588360dc5db2f137f8eba08f69d 434 SUPERFAMILY SSF52425 2 184 9.42E-48 T 21-04-2016 IPR006050 DNA photolyase, N-terminal SPH21_RS14635 8ffb8267709636f6c0376f424bb47a89 570 Pfam PF07980 SusD family 271 570 5.1E-39 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14635 8ffb8267709636f6c0376f424bb47a89 570 SUPERFAMILY SSF48452 19 570 1.9E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14635 8ffb8267709636f6c0376f424bb47a89 570 Pfam PF14322 Starch-binding associating with outer membrane 24 233 1.5E-21 T 21-04-2016 SPH21_RS14635 8ffb8267709636f6c0376f424bb47a89 570 Gene3D G3DSA:1.25.40.10 215 319 3.8E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14635 8ffb8267709636f6c0376f424bb47a89 570 Gene3D G3DSA:1.25.40.10 393 505 3.8E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14440 722cb0e56ca28a2fef286d5139f33948 511 SUPERFAMILY SSF48452 6 511 1.39E-132 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14440 722cb0e56ca28a2fef286d5139f33948 511 Pfam PF14322 Starch-binding associating with outer membrane 12 211 9.3E-26 T 21-04-2016 SPH21_RS14440 722cb0e56ca28a2fef286d5139f33948 511 Pfam PF07980 SusD family 287 511 4.2E-49 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14440 722cb0e56ca28a2fef286d5139f33948 511 Gene3D G3DSA:1.25.40.10 193 299 2.3E-45 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14440 722cb0e56ca28a2fef286d5139f33948 511 Gene3D G3DSA:1.25.40.10 351 448 2.3E-45 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14275 e8ce6a44f2455aecc9241bd9ad7eea79 333 Gene3D G3DSA:3.20.20.100 1 324 5.0E-111 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS14275 e8ce6a44f2455aecc9241bd9ad7eea79 333 SUPERFAMILY SSF51430 1 317 1.57E-96 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS14275 e8ce6a44f2455aecc9241bd9ad7eea79 333 PANTHER PTHR11732 1 325 4.7E-137 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS14275 e8ce6a44f2455aecc9241bd9ad7eea79 333 Pfam PF00248 Aldo/keto reductase family 16 314 2.9E-77 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS14275 e8ce6a44f2455aecc9241bd9ad7eea79 333 PANTHER PTHR11732:SF12 1 325 4.7E-137 T 21-04-2016 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 PANTHER PTHR10357 430 543 1.5E-174 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 PANTHER PTHR10357 1 398 1.5E-174 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 Gene3D G3DSA:3.20.20.80 5 106 7.9E-119 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 Gene3D G3DSA:3.20.20.80 178 454 7.9E-119 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 Pfam PF00128 Alpha amylase, catalytic domain 30 367 1.1E-101 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 PANTHER PTHR10357:SF167 430 543 1.5E-174 T 21-04-2016 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 PANTHER PTHR10357:SF167 1 398 1.5E-174 T 21-04-2016 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 SUPERFAMILY SSF51445 6 451 3.7E-144 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 Gene3D G3DSA:3.90.400.10 107 177 6.5E-32 T 21-04-2016 SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 Pfam PF11941 Domain of unknown function (DUF3459) 437 513 8.3E-5 T 21-04-2016 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) SPH21_RS18930 949266b664d2efebdbe4aecd503b7699 545 SMART SM00642 15 393 7.3E-142 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS21550 9f2610cc192c911d219b0f1325dba5c1 141 Pfam PF01047 MarR family 32 88 1.4E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS21550 9f2610cc192c911d219b0f1325dba5c1 141 SMART SM00347 24 124 9.2E-14 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS21550 9f2610cc192c911d219b0f1325dba5c1 141 Gene3D G3DSA:1.10.10.10 10 137 1.8E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21550 9f2610cc192c911d219b0f1325dba5c1 141 ProSitePatterns PS01117 MarR-type HTH domain signature. 63 97 - T 21-04-2016 IPR023187 Transcriptional regulator MarR-type, conserved site SPH21_RS21550 9f2610cc192c911d219b0f1325dba5c1 141 SUPERFAMILY SSF46785 29 137 2.94E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 Gene3D G3DSA:3.90.1150.10 21 88 2.5E-38 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 Gene3D G3DSA:3.90.1150.10 338 442 2.5E-38 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 TIGRFAM TIGR00713 hemL: glutamate-1-semialdehyde-2,1-aminomutase 22 442 1.1E-168 T 21-04-2016 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 Pfam PF00202 Aminotransferase class-III 51 418 3.1E-74 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 PANTHER PTHR11986:SF5 21 447 1.4E-187 T 21-04-2016 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 253 289 - T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 SUPERFAMILY SSF53383 20 443 1.15E-118 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 Gene3D G3DSA:3.40.640.10 89 334 6.5E-72 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 PANTHER PTHR11986 21 447 1.4E-187 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS25575 096600e53969dbb027ce26310b168c8f 447 Hamap MF_00375 Glutamate-1-semialdehyde 2,1-aminomutase [hemL]. 22 445 88.502 T 21-04-2016 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 PANTHER PTHR30173 1 190 2.3E-36 T 21-04-2016 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 49 80 - T 21-04-2016 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 SUPERFAMILY SSF88946 7 95 2.31E-19 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 Gene3D G3DSA:1.10.1740.10 7 119 6.8E-21 T 21-04-2016 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 175 5.4E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 PANTHER PTHR30173:SF20 1 190 2.3E-36 T 21-04-2016 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 SUPERFAMILY SSF88659 119 177 1.28E-10 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 Pfam PF08281 Sigma-70, region 4 122 172 3.3E-11 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 Gene3D G3DSA:1.10.10.10 121 178 2.9E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13815 f4ee445e631db333e2e783a2fc4e41a1 201 Pfam PF04542 Sigma-70 region 2 28 92 7.8E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 7 255 2.8E-60 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 ProSitePatterns PS00933 FGGY family of carbohydrate kinases signature 1. 138 150 - T 21-04-2016 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 Gene3D G3DSA:3.30.420.40 3 255 9.2E-81 T 21-04-2016 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 PANTHER PTHR10196:SF69 7 462 2.6E-168 T 21-04-2016 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 PIRSF PIRSF000538 4 497 2.8E-128 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 PANTHER PTHR10196 7 462 2.6E-168 T 21-04-2016 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 365 385 - T 21-04-2016 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 SUPERFAMILY SSF53067 258 488 1.57E-58 T 21-04-2016 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 264 453 7.2E-42 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 SUPERFAMILY SSF53067 7 258 3.46E-75 T 21-04-2016 SPH21_RS13005 9b3b9e89917620b3ff93a9c71310e6fb 497 Gene3D G3DSA:3.30.420.40 258 496 4.0E-69 T 21-04-2016 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 Pfam PF04055 Radical SAM superfamily 148 319 5.1E-22 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 TIGRFAM TIGR01579 MiaB-like-C: MiaB-like tRNA modifying enzyme 7 418 9.0E-127 T 21-04-2016 IPR006467 MiaB-like tRNA modifying enzyme GO:0016740 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 SMART SM00729 142 361 4.8E-41 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 4 424 7.4E-120 T 21-04-2016 IPR005839 Methylthiotransferase GO:0016740|GO:0043412|GO:0051539 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 Gene3D G3DSA:3.80.30.20 140 371 5.2E-67 T 21-04-2016 IPR023404 Radical SAM, alpha/beta horseshoe SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 PANTHER PTHR11918 1 425 4.1E-113 T 21-04-2016 IPR023970 Methylthiotransferase/radical SAM-type protein SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 146 166 - T 21-04-2016 IPR020612 Methylthiotransferase, conserved site GO:0051539 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 Pfam PF00919 Uncharacterized protein family UPF0004 4 99 4.8E-24 T 21-04-2016 IPR013848 Methylthiotransferase, N-terminal GO:0003824|GO:0009451|GO:0051539 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 SUPERFAMILY SSF102114 134 365 2.88E-50 T 21-04-2016 SPH21_RS15195 68f6dfbdf158d616b96c385abe8f876a 439 PANTHER PTHR11918:SF45 1 425 4.1E-113 T 21-04-2016 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 PANTHER PTHR10381 37 225 1.2E-99 T 21-04-2016 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 Gene3D G3DSA:3.90.226.10 52 226 3.7E-73 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 Pfam PF00574 Clp protease 52 225 4.7E-73 T 21-04-2016 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 38 228 38.512 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 PRINTS PR00127 Clp protease catalytic subunit P signature 94 114 3.5E-45 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 PRINTS PR00127 Clp protease catalytic subunit P signature 54 69 3.5E-45 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 PRINTS PR00127 Clp protease catalytic subunit P signature 125 142 3.5E-45 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 PRINTS PR00127 Clp protease catalytic subunit P signature 146 165 3.5E-45 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 PRINTS PR00127 Clp protease catalytic subunit P signature 203 222 3.5E-45 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 PANTHER PTHR10381:SF22 37 225 1.2E-99 T 21-04-2016 SPH21_RS14555 71efac9ffd49f41c62fcc6adc309bfff 231 SUPERFAMILY SSF52096 48 225 2.8E-63 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS09805 ee861b407e10346221cbcfa0e0f694fd 229 Pfam PF00849 RNA pseudouridylate synthase 14 168 2.4E-31 T 21-04-2016 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS09805 ee861b407e10346221cbcfa0e0f694fd 229 PANTHER PTHR11079 8 226 6.7E-52 T 21-04-2016 SPH21_RS09805 ee861b407e10346221cbcfa0e0f694fd 229 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 57 71 - T 21-04-2016 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS09805 ee861b407e10346221cbcfa0e0f694fd 229 PANTHER PTHR11079:SF83 8 226 6.7E-52 T 21-04-2016 SPH21_RS09805 ee861b407e10346221cbcfa0e0f694fd 229 SUPERFAMILY SSF55120 8 217 3.36E-53 T 21-04-2016 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS00610 b1522279987b33f3dfca82e990ad9f5a 214 PANTHER PTHR15020:SF24 1 209 1.4E-17 T 21-04-2016 SPH21_RS00610 b1522279987b33f3dfca82e990ad9f5a 214 Pfam PF13460 NAD(P)H-binding 7 187 7.2E-40 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00610 b1522279987b33f3dfca82e990ad9f5a 214 Gene3D G3DSA:3.40.50.720 1 205 1.9E-31 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00610 b1522279987b33f3dfca82e990ad9f5a 214 PANTHER PTHR15020 1 209 1.4E-17 T 21-04-2016 SPH21_RS00610 b1522279987b33f3dfca82e990ad9f5a 214 SUPERFAMILY SSF51735 1 204 1.3E-28 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02435 083deb1fd15651d4be57fbca66aec3f0 468 PANTHER PTHR22925 29 320 2.5E-63 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02435 083deb1fd15651d4be57fbca66aec3f0 468 Gene3D G3DSA:2.115.10.20 42 265 2.1E-29 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02435 083deb1fd15651d4be57fbca66aec3f0 468 SUPERFAMILY SSF75005 44 312 6.57E-43 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02435 083deb1fd15651d4be57fbca66aec3f0 468 Pfam PF04616 Glycosyl hydrolases family 43 48 248 4.5E-15 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02435 083deb1fd15651d4be57fbca66aec3f0 468 PANTHER PTHR22925:SF3 29 320 2.5E-63 T 21-04-2016 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 PRINTS PR00064 Ribosomal protein L35 signature 36 54 5.4E-20 T 21-04-2016 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 PRINTS PR00064 Ribosomal protein L35 signature 3 20 5.4E-20 T 21-04-2016 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 PRINTS PR00064 Ribosomal protein L35 signature 21 35 5.4E-20 T 21-04-2016 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 Hamap MF_00514 50S ribosomal protein L35 [rpmI]. 1 64 18.905 T 21-04-2016 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 SUPERFAMILY SSF143034 2 63 2.49E-23 T 21-04-2016 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 Pfam PF01632 Ribosomal protein L35 2 62 1.0E-26 T 21-04-2016 IPR021137 Ribosomal protein L35 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 TIGRFAM TIGR00001 rpmI_bact: ribosomal protein bL35 2 62 1.5E-28 T 21-04-2016 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 ProSitePatterns PS00936 Ribosomal protein L35 signature. 5 31 - T 21-04-2016 IPR018265 Ribosomal protein L35, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS14760 c376287c07eba54340266940e47a5dc2 66 PANTHER PTHR33343 1 62 1.3E-24 T 21-04-2016 SPH21_RS22680 3a92f6f521b33e5657034dae50300549 370 SUPERFAMILY SSF46689 313 364 1.97E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22680 3a92f6f521b33e5657034dae50300549 370 PANTHER PTHR11019 270 370 9.2E-14 T 21-04-2016 SPH21_RS22680 3a92f6f521b33e5657034dae50300549 370 SMART SM00342 277 363 5.3E-12 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22680 3a92f6f521b33e5657034dae50300549 370 Pfam PF12833 Helix-turn-helix domain 284 364 2.2E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22680 3a92f6f521b33e5657034dae50300549 370 Gene3D G3DSA:1.10.10.60 312 365 5.0E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22680 3a92f6f521b33e5657034dae50300549 370 PANTHER PTHR11019:SF65 270 370 9.2E-14 T 21-04-2016 SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 ProSitePatterns PS00054 Ribosomal protein S11 signature. 97 119 - T 21-04-2016 IPR018102 Ribosomal S11, conserved site SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 Pfam PF00411 Ribosomal protein S11 19 128 5.9E-44 T 21-04-2016 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 Hamap MF_01310 30S ribosomal protein S11 [rpsK]. 3 129 31.228 T 21-04-2016 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 PANTHER PTHR11759 3 129 2.6E-55 T 21-04-2016 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 SUPERFAMILY SSF53137 17 129 4.19E-46 T 21-04-2016 SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 PIRSF PIRSF002131 1 129 5.0E-51 T 21-04-2016 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 Gene3D G3DSA:3.30.420.80 9 129 2.4E-51 T 21-04-2016 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08615 744bff0199a9013626ee7597c824958f 129 TIGRFAM TIGR03632 uS11_bact: ribosomal protein uS11 17 126 1.6E-53 T 21-04-2016 IPR019981 Ribosomal protein S11, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16770 ba97ea5722479afb6047de6d6d3207ca 311 Pfam PF04168 A predicted alpha-helical domain with a conserved ER motif. 1 309 1.4E-67 T 21-04-2016 IPR007296 Domain of unknown function DUF403 SPH21_RS16770 ba97ea5722479afb6047de6d6d3207ca 311 PANTHER PTHR34595 1 311 8.2E-54 T 21-04-2016 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 Gene3D G3DSA:1.10.1740.10 14 124 4.6E-21 T 21-04-2016 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 Pfam PF08281 Sigma-70, region 4 138 185 8.2E-10 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 33 189 1.1E-26 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 SUPERFAMILY SSF88659 131 191 2.62E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 PANTHER PTHR30173:SF20 9 191 2.6E-41 T 21-04-2016 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 Gene3D G3DSA:1.10.10.10 132 191 2.6E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 33 189 5.0E-41 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 Pfam PF04542 Sigma-70 region 2 37 102 1.8E-12 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 PANTHER PTHR30173 9 191 2.6E-41 T 21-04-2016 SPH21_RS14085 b0e22c2c248b7d3d3823b1daba5377f5 195 SUPERFAMILY SSF88946 13 112 6.28E-20 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 TIGRFAM TIGR01133 murG: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 1 362 3.5E-93 T 21-04-2016 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 PANTHER PTHR21015 2 368 5.7E-120 T 21-04-2016 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 PANTHER PTHR21015:SF22 2 368 5.7E-120 T 21-04-2016 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 Gene3D G3DSA:3.40.50.2000 3 207 8.4E-63 T 21-04-2016 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 Hamap MF_00033 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [murG]. 8 367 31.793 T 21-04-2016 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 SUPERFAMILY SSF53756 6 368 6.96E-104 T 21-04-2016 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 Pfam PF03033 Glycosyltransferase family 28 N-terminal domain 8 146 2.5E-33 T 21-04-2016 IPR004276 Glycosyltransferase family 28, N-terminal domain GO:0005975|GO:0016758|GO:0030259 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00275 2042d5fe8dbbe49ff445e375d31443ec 371 Pfam PF04101 Glycosyltransferase family 28 C-terminal domain 195 347 1.5E-37 T 21-04-2016 IPR007235 Glycosyl transferase, family 28, C-terminal GO:0016758 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 Gene3D G3DSA:1.10.10.10 121 182 2.0E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 Gene3D G3DSA:1.10.1740.10 8 116 2.7E-20 T 21-04-2016 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 25 180 3.3E-39 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 Pfam PF04542 Sigma-70 region 2 29 92 8.8E-10 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 28 179 1.4E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 Pfam PF08281 Sigma-70, region 4 126 176 2.6E-14 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 SUPERFAMILY SSF88946 8 105 1.54E-19 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 PANTHER PTHR30173:SF20 1 193 1.8E-35 T 21-04-2016 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 SUPERFAMILY SSF88659 123 182 1.35E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09345 be6acbc0f863c97f13011c3b34f0f889 194 PANTHER PTHR30173 1 193 1.8E-35 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 SUPERFAMILY SSF49464 178 256 6.67E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Gene3D G3DSA:2.170.130.10 269 397 1.2E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 371 401 1.1E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532 176 342 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532 665 1159 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532 548 590 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532 362 527 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532:SF57 176 342 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532:SF57 665 1159 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532:SF57 548 590 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 PANTHER PTHR11532:SF57 362 527 3.4E-245 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 178 1161 5.8E-257 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Pfam PF07715 TonB-dependent Receptor Plug Domain 269 395 1.5E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Gene3D G3DSA:2.40.170.20 398 415 4.2E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Gene3D G3DSA:2.40.170.20 1075 1161 4.2E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Gene3D G3DSA:2.40.170.20 482 927 4.2E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Gene3D G3DSA:2.40.170.20 973 1037 4.2E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Gene3D G3DSA:2.60.40.1120 60 130 2.0E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Gene3D G3DSA:2.60.40.1120 179 260 4.7E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 SUPERFAMILY SSF49464 59 131 5.49E-10 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 SUPERFAMILY SSF56935 473 561 4.76E-106 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 SUPERFAMILY SSF56935 983 1027 4.76E-106 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 SUPERFAMILY SSF56935 593 927 4.76E-106 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 SUPERFAMILY SSF56935 1065 1161 4.76E-106 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 SUPERFAMILY SSF56935 257 419 4.76E-106 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Pfam PF13715 CarboxypepD_reg-like domain 61 133 6.8E-9 T 21-04-2016 SPH21_RS11710 315f45ec2b3ab622683d982d277ecf63 1161 Pfam PF13715 CarboxypepD_reg-like domain 179 258 6.9E-16 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 SUPERFAMILY SSF51905 208 334 2.0E-27 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 SUPERFAMILY SSF51905 2 99 2.0E-27 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PANTHER PTHR22912 1 137 2.8E-24 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PANTHER PTHR22912 191 329 2.8E-24 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PANTHER PTHR22912 154 175 2.8E-24 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 2 322 1.3E-46 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 155 180 1.0E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 292 299 1.0E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 238 252 1.0E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 2 24 1.0E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 95 113 2.5E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 155 173 2.5E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 277 299 2.5E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 3 22 2.5E-9 T 21-04-2016 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 Gene3D G3DSA:3.50.50.60 102 329 7.3E-30 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22460 0463db254b9e3bf2a3a3f72f9a23bea7 425 Gene3D G3DSA:3.50.50.60 1 101 2.6E-19 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 PIRSF PIRSF001435 1 212 5.0E-51 T 21-04-2016 IPR005759 Endonuclease III GO:0003906|GO:0006284 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 SMART SM00478 39 187 9.2E-60 T 21-04-2016 IPR003265 HhH-GPD domain GO:0006284 Reactome: REACT_216 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 Gene3D G3DSA:1.10.1670.10 124 210 1.3E-35 T 21-04-2016 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 Pfam PF00633 Helix-hairpin-helix motif 101 128 8.0E-8 T 21-04-2016 IPR000445 Helix-hairpin-helix motif GO:0003677 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 PANTHER PTHR10359 19 213 8.8E-80 T 21-04-2016 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 Gene3D G3DSA:1.10.340.30 23 123 5.1E-37 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 SMART SM00525 188 208 3.1E-5 T 21-04-2016 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: REACT_216 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 35 170 9.5E-24 T 21-04-2016 IPR003265 HhH-GPD domain GO:0006284 Reactome: REACT_216 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 Hamap MF_00942 Endonuclease III [nth]. 1 211 38.839 T 21-04-2016 IPR005759 Endonuclease III GO:0003906|GO:0006284 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 TIGRFAM TIGR01083 nth: endonuclease III 7 196 3.5E-76 T 21-04-2016 IPR005759 Endonuclease III GO:0003906|GO:0006284 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 ProSitePatterns PS01155 Endonuclease III family signature. 103 132 - T 21-04-2016 IPR004036 Endonuclease III-like, conserved site-2 Reactome: REACT_216 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 Pfam PF10576 Iron-sulfur binding domain of endonuclease III 189 205 3.7E-4 T 21-04-2016 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: REACT_216 SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 ProSitePatterns PS00764 Endonuclease III iron-sulfur binding region signature. 189 205 - T 21-04-2016 IPR004035 Endonuclease III, iron-sulphur binding site SPH21_RS02815 652988f6d9a553f183c784c7deea4ab3 221 SUPERFAMILY SSF48150 2 210 2.51E-73 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS14325 2361c8615353791754ab503de294701f 327 Gene3D G3DSA:2.160.20.10 22 325 3.5E-110 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS14325 2361c8615353791754ab503de294701f 327 PANTHER PTHR31321 24 321 3.4E-128 T 21-04-2016 SPH21_RS14325 2361c8615353791754ab503de294701f 327 Pfam PF01095 Pectinesterase 27 319 3.2E-69 T 21-04-2016 IPR000070 Pectinesterase, catalytic GO:0005618|GO:0030599|GO:0042545 KEGG: 00040+3.1.1.11|KEGG: 00500+3.1.1.11|MetaCyc: PWY-1081|MetaCyc: PWY-7246|MetaCyc: PWY-7248|UniPathway: UPA00545 SPH21_RS14325 2361c8615353791754ab503de294701f 327 PANTHER PTHR31321:SF1 24 321 3.4E-128 T 21-04-2016 SPH21_RS14325 2361c8615353791754ab503de294701f 327 SUPERFAMILY SSF51126 22 321 3.14E-80 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS14325 2361c8615353791754ab503de294701f 327 ProSitePatterns PS00503 Pectinesterase signature 2. 184 193 - T 21-04-2016 IPR033131 Pectinesterase, Asp active site KEGG: 00040+3.1.1.11|KEGG: 00500+3.1.1.11|MetaCyc: PWY-1081|MetaCyc: PWY-7246|MetaCyc: PWY-7248|UniPathway: UPA00545 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 Gene3D G3DSA:3.50.50.60 26 266 1.8E-45 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 SUPERFAMILY SSF51905 26 243 1.17E-33 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 ProSitePatterns PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 378 388 - T 21-04-2016 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 SUPERFAMILY SSF54373 253 347 9.22E-6 T 21-04-2016 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 PANTHER PTHR11985 12 517 1.6E-218 T 21-04-2016 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 Pfam PF16901 C-terminal domain of alpha-glycerophosphate oxidase 414 510 1.0E-21 T 21-04-2016 IPR031656 Alpha-glycerophosphate oxidase, C-terminal KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 55 67 1.7E-28 T 21-04-2016 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 341 347 1.7E-28 T 21-04-2016 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 373 385 1.7E-28 T 21-04-2016 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 26 38 1.7E-28 T 21-04-2016 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 39 49 1.7E-28 T 21-04-2016 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 100 112 1.7E-28 T 21-04-2016 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952 SPH21_RS14470 9c950f4efb5bcf87e801217af0b682b9 532 Pfam PF01266 FAD dependent oxidoreductase 27 384 1.3E-47 T 21-04-2016 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 Pfam PF00171 Aldehyde dehydrogenase family 23 473 1.2E-172 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 PANTHER PTHR11699 1 476 1.0E-274 T 21-04-2016 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 SUPERFAMILY SSF53720 8 477 1.17E-170 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 PANTHER PTHR11699:SF49 1 476 1.0E-274 T 21-04-2016 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 Gene3D G3DSA:3.40.309.10 267 449 3.7E-68 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 TIGRFAM TIGR01780 SSADH: succinate-semialdehyde dehydrogenase 27 472 1.3E-205 T 21-04-2016 IPR010102 Succinate semialdehyde dehydrogenase GO:0009013|GO:0009450|GO:0055114 UniPathway: UPA00733 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 252 259 - T 21-04-2016 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 280 291 - T 21-04-2016 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SPH21_RS25825 c93e375bff10937a0748d31266a3d8f4 478 Gene3D G3DSA:3.40.605.10 12 266 4.5E-102 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Pfam PF07715 TonB-dependent Receptor Plug Domain 145 248 2.0E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Gene3D G3DSA:2.170.130.10 145 250 7.3E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Pfam PF00593 TonB dependent receptor 651 1075 3.2E-17 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 224 254 1.7E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 PANTHER PTHR11532 604 1074 1.0E-258 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 PANTHER PTHR11532 540 567 1.0E-258 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 PANTHER PTHR11532 51 462 1.0E-258 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Gene3D G3DSA:2.60.40.1120 53 143 5.5E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Gene3D G3DSA:2.40.170.20 913 938 2.0E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Gene3D G3DSA:2.40.170.20 972 1076 2.0E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Gene3D G3DSA:2.40.170.20 251 268 2.0E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Gene3D G3DSA:2.40.170.20 338 851 2.0E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 PANTHER PTHR11532:SF57 604 1074 1.0E-258 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 PANTHER PTHR11532:SF57 540 567 1.0E-258 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 PANTHER PTHR11532:SF57 51 462 1.0E-258 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 52 1076 7.5E-273 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 SUPERFAMILY SSF49464 52 132 3.4E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 SUPERFAMILY SSF56935 134 276 1.51E-85 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 SUPERFAMILY SSF56935 456 694 1.51E-85 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 SUPERFAMILY SSF56935 985 1076 1.51E-85 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 SUPERFAMILY SSF56935 905 948 1.51E-85 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 SUPERFAMILY SSF56935 722 822 1.51E-85 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 SUPERFAMILY SSF56935 338 429 1.51E-85 T 21-04-2016 SPH21_RS04565 47f833cf0ac87d063b4b721873e59994 1076 Pfam PF13715 CarboxypepD_reg-like domain 54 135 1.6E-18 T 21-04-2016 SPH21_RS20360 3813a287912d9a99e877709a1bd7d534 106 Gene3D G3DSA:3.30.110.70 1 105 9.1E-40 T 21-04-2016 IPR002765 Uncharacterised protein family UPF0145 SPH21_RS20360 3813a287912d9a99e877709a1bd7d534 106 PANTHER PTHR34068 1 106 9.7E-43 T 21-04-2016 SPH21_RS20360 3813a287912d9a99e877709a1bd7d534 106 Pfam PF01906 Putative heavy-metal-binding 1 105 1.4E-40 T 21-04-2016 IPR002765 Uncharacterised protein family UPF0145 SPH21_RS20360 3813a287912d9a99e877709a1bd7d534 106 PANTHER PTHR34068:SF1 1 106 9.7E-43 T 21-04-2016 SPH21_RS20360 3813a287912d9a99e877709a1bd7d534 106 SUPERFAMILY SSF117782 1 106 2.88E-40 T 21-04-2016 IPR002765 Uncharacterised protein family UPF0145 SPH21_RS20360 3813a287912d9a99e877709a1bd7d534 106 Hamap MF_00338 UPF0145 protein YbjQ [ybjQ]. 1 105 25.435 T 21-04-2016 IPR002765 Uncharacterised protein family UPF0145 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 PANTHER PTHR22642 22 545 3.8E-166 T 21-04-2016 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 Gene3D G3DSA:2.30.40.10 490 545 1.6E-5 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 PANTHER PTHR22642:SF2 22 545 3.8E-166 T 21-04-2016 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 SUPERFAMILY SSF51556 218 505 8.26E-28 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 SUPERFAMILY SSF51556 83 140 8.26E-28 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 Gene3D G3DSA:3.20.20.140 95 106 1.2E-20 T 21-04-2016 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 Gene3D G3DSA:3.20.20.140 220 489 1.2E-20 T 21-04-2016 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 SUPERFAMILY SSF51338 23 84 3.38E-16 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 SUPERFAMILY SSF51338 504 545 3.38E-16 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 Gene3D G3DSA:2.30.40.10 21 94 9.4E-11 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS17995 ffdf8d8e835406c9e540d107900a525c 545 Pfam PF07969 Amidohydrolase family 74 545 3.9E-85 T 21-04-2016 IPR013108 Amidohydrolase 3 SPH21_RS21040 07d0c8e0e498a4243afda57f9f5372db 552 Pfam PF14322 Starch-binding associating with outer membrane 34 231 8.6E-21 T 21-04-2016 SPH21_RS21040 07d0c8e0e498a4243afda57f9f5372db 552 SUPERFAMILY SSF48452 26 552 1.67E-110 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21040 07d0c8e0e498a4243afda57f9f5372db 552 Gene3D G3DSA:1.25.40.10 211 326 9.9E-48 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21040 07d0c8e0e498a4243afda57f9f5372db 552 Gene3D G3DSA:1.25.40.10 400 493 9.9E-48 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21040 07d0c8e0e498a4243afda57f9f5372db 552 Pfam PF07980 SusD family 270 552 1.3E-47 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 ProSitePatterns PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 37 47 - T 21-04-2016 IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site GO:0016668|GO:0055114 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 Gene3D G3DSA:3.50.50.60 2 137 1.9E-43 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PANTHER PTHR22912 1 455 2.7E-198 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 339 360 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 4 26 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 426 446 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 261 275 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 137 146 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 36 51 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 173 198 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 303 310 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 404 419 9.4E-67 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 SUPERFAMILY SSF51905 1 368 7.5E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PIRSF PIRSF000350 1 459 9.2E-85 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PANTHER PTHR22912:SF125 1 455 2.7E-198 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 343 451 1.7E-36 T 21-04-2016 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 Gene3D G3DSA:3.50.50.60 138 329 1.0E-55 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 2 461 6.3E-175 T 21-04-2016 IPR006258 Dihydrolipoamide dehydrogenase GO:0004148|GO:0050660|GO:0055114 KEGG: 00010+1.8.1.4|KEGG: 00020+1.8.1.4|KEGG: 00260+1.8.1.4|KEGG: 00280+1.8.1.4|KEGG: 00620+1.8.1.4|KEGG: 00640+1.8.1.4|MetaCyc: PWY-5046|MetaCyc: PWY-5084 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 SUPERFAMILY SSF55424 339 461 7.22E-40 T 21-04-2016 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 5 24 6.1E-39 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 173 191 6.1E-39 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 134 152 6.1E-39 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 288 310 6.1E-39 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 260 276 6.1E-39 T 21-04-2016 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 Gene3D G3DSA:3.30.390.30 330 461 9.9E-48 T 21-04-2016 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SPH21_RS17125 a957de3c665f066f5dab565ed0e37049 462 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 3 323 6.3E-70 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13830 ffe6acc68d90d8fd426c609ff3196e7a 506 SUPERFAMILY SSF48452 22 506 9.49E-115 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13830 ffe6acc68d90d8fd426c609ff3196e7a 506 Pfam PF14322 Starch-binding associating with outer membrane 99 226 6.6E-20 T 21-04-2016 SPH21_RS13830 ffe6acc68d90d8fd426c609ff3196e7a 506 Pfam PF07980 SusD family 269 506 2.1E-37 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13830 ffe6acc68d90d8fd426c609ff3196e7a 506 Gene3D G3DSA:1.25.40.10 209 448 1.3E-34 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 Pfam PF06832 Penicillin-Binding Protein C-terminus Family 697 777 2.4E-10 T 21-04-2016 IPR009647 Penicillin-binding, C-terminal KEGG: 00230+2.4.2.-|KEGG: 00514+2.4.2.-|UniPathway: UPA00219 SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 Gene3D G3DSA:3.40.710.10 229 642 3.4E-71 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 SUPERFAMILY SSF53955 40 260 3.09E-59 T 21-04-2016 IPR023346 Lysozyme-like domain SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 TIGRFAM TIGR02073 PBP_1c: penicillin-binding protein 1C 37 783 1.5E-201 T 21-04-2016 IPR011815 Penicillin-binding protein 1C GO:0008955|GO:0009252 KEGG: 00230+2.4.2.-|KEGG: 00514+2.4.2.-|UniPathway: UPA00219 SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 PANTHER PTHR32282 32 699 3.4E-148 T 21-04-2016 SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 Gene3D G3DSA:1.10.3810.10 68 228 5.4E-48 T 21-04-2016 SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 PANTHER PTHR32282:SF0 32 699 3.4E-148 T 21-04-2016 SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 Pfam PF00912 Transglycosylase 68 227 1.6E-44 T 21-04-2016 IPR001264 Glycosyl transferase, family 51 UniPathway: UPA00219 SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 SUPERFAMILY SSF56601 209 633 1.73E-79 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS20470 cac89dc0c7f3cbc52619951961e93f36 787 Pfam PF00905 Penicillin binding protein transpeptidase domain 305 563 2.2E-11 T 21-04-2016 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SPH21_RS00590 9a9688dacd500ed063360f5632ba9b89 162 PANTHER PTHR33570:SF5 29 156 1.3E-37 T 21-04-2016 SPH21_RS00590 9a9688dacd500ed063360f5632ba9b89 162 SUPERFAMILY SSF51182 35 156 6.23E-28 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS00590 9a9688dacd500ed063360f5632ba9b89 162 Pfam PF07883 Cupin domain 70 132 2.3E-12 T 21-04-2016 IPR013096 Cupin 2, conserved barrel SPH21_RS00590 9a9688dacd500ed063360f5632ba9b89 162 PANTHER PTHR33570 29 156 1.3E-37 T 21-04-2016 SPH21_RS00590 9a9688dacd500ed063360f5632ba9b89 162 Gene3D G3DSA:2.60.120.10 32 156 8.9E-27 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS10185 4e4b8c8bda6431909622f76a20697310 251 Pfam PF02397 Bacterial sugar transferase 64 246 4.1E-57 T 21-04-2016 IPR003362 Bacterial sugar transferase SPH21_RS10185 4e4b8c8bda6431909622f76a20697310 251 PANTHER PTHR30576 34 250 1.7E-84 T 21-04-2016 SPH21_RS10515 8b90e7c33d523f66e77c3e9355c8b40e 164 Pfam PF13238 AAA domain 11 119 2.9E-10 T 21-04-2016 SPH21_RS10515 8b90e7c33d523f66e77c3e9355c8b40e 164 SUPERFAMILY SSF52540 9 160 1.56E-15 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS10515 8b90e7c33d523f66e77c3e9355c8b40e 164 Gene3D G3DSA:3.40.50.300 8 161 8.3E-16 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS10515 8b90e7c33d523f66e77c3e9355c8b40e 164 PRINTS PR01100 Shikimate kinase family signature 89 106 3.1E-5 T 21-04-2016 SPH21_RS10515 8b90e7c33d523f66e77c3e9355c8b40e 164 PRINTS PR01100 Shikimate kinase family signature 11 26 3.1E-5 T 21-04-2016 SPH21_RS11840 13e6a1693cb81ccfc28a872ed520996f 116 TIGRFAM TIGR00741 yfiA: ribosomal subunit interface protein 1 100 3.1E-12 T 21-04-2016 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SPH21_RS11840 13e6a1693cb81ccfc28a872ed520996f 116 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein 3 96 8.2E-15 T 21-04-2016 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SPH21_RS11840 13e6a1693cb81ccfc28a872ed520996f 116 Gene3D G3DSA:3.30.160.100 1 98 2.3E-20 T 21-04-2016 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SPH21_RS11840 13e6a1693cb81ccfc28a872ed520996f 116 SUPERFAMILY SSF69754 1 93 3.14E-19 T 21-04-2016 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 Pfam PF13715 CarboxypepD_reg-like domain 25 110 8.1E-19 T 21-04-2016 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 Pfam PF00593 TonB dependent receptor 476 705 2.9E-11 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 SUPERFAMILY SSF56935 106 706 5.29E-90 T 21-04-2016 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 Gene3D G3DSA:2.170.130.10 108 228 8.5E-34 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 Gene3D G3DSA:2.40.170.20 229 710 6.5E-63 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 Gene3D G3DSA:2.40.170.20 752 777 6.5E-63 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 SUPERFAMILY SSF49464 29 118 4.19E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 Pfam PF07715 TonB-dependent Receptor Plug Domain 120 224 2.5E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 PANTHER PTHR30069:SF2 6 536 3.5E-55 T 21-04-2016 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 PANTHER PTHR30069 6 536 3.5E-55 T 21-04-2016 SPH21_RS13795 57a4456301e13b314ab8d15aa512ba6d 780 Gene3D G3DSA:2.60.40.1120 25 107 1.3E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 470 493 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 363 384 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 632 646 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 36 54 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 391 415 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 8 32 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 563 580 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 336 359 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PRINTS PR00702 Acriflavin resistance protein family signature 445 468 1.1E-87 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82714 185 271 2.62E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 Gene3D G3DSA:3.30.70.1430 38 139 3.9E-30 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82866 841 1036 4.84E-43 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82693 142 184 2.62E-18 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 Gene3D G3DSA:3.30.2090.10 732 816 8.9E-21 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 Gene3D G3DSA:3.30.2090.10 184 271 3.4E-21 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 Gene3D G3DSA:1.20.1640.10 292 507 1.5E-61 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PANTHER PTHR32063 1 1053 0.0 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 Gene3D G3DSA:1.10.3850.10 824 1037 7.4E-56 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82866 297 498 4.19E-51 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82693 38 129 2.09E-25 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82714 732 815 1.44E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82693 818 867 8.2E-24 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82693 682 731 8.2E-24 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82693 576 681 2.04E-17 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 PANTHER PTHR32063:SF9 1 1053 0.0 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 2 1046 0.0 T 21-04-2016 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0005215|GO:0006810|GO:0016021 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 Pfam PF00873 AcrB/AcrD/AcrF family 1 1037 0.0 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 Gene3D G3DSA:3.30.70.1430 581 681 1.1E-17 T 21-04-2016 SPH21_RS02075 388d7f978cc43bd6077aebb054b1f146 1053 SUPERFAMILY SSF82693 274 327 2.62E-18 T 21-04-2016 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 Pfam PF00196 Bacterial regulatory proteins, luxR family 148 201 1.2E-18 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 SUPERFAMILY SSF52172 1 128 1.71E-30 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 PANTHER PTHR26402 2 201 3.2E-53 T 21-04-2016 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 Gene3D G3DSA:3.40.50.2300 1 119 5.2E-32 T 21-04-2016 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 Pfam PF00072 Response regulator receiver domain 4 116 1.2E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 SUPERFAMILY SSF46894 141 206 1.73E-17 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 SMART SM00421 144 201 4.4E-17 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 Gene3D G3DSA:1.10.10.10 120 206 1.6E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 SMART SM00448 2 115 8.1E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 PANTHER PTHR26402:SF458 2 201 3.2E-53 T 21-04-2016 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 147 161 3.1E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 177 189 3.1E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20465 9198f29b32e183fd3b02907a53224c00 207 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 161 177 3.1E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 SUPERFAMILY SSF88659 121 182 1.44E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 Gene3D G3DSA:1.10.10.10 126 182 6.1E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 PANTHER PTHR30173 1 192 9.2E-40 T 21-04-2016 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 25 181 1.1E-22 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 SUPERFAMILY SSF88946 4 102 4.32E-20 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 27 182 4.8E-40 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 Gene3D G3DSA:1.10.1740.10 6 102 7.2E-22 T 21-04-2016 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 PANTHER PTHR30173:SF20 1 192 9.2E-40 T 21-04-2016 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 Pfam PF08281 Sigma-70, region 4 128 174 6.9E-12 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03955 143c517ec30deccb054a906d9d76b01d 198 Pfam PF04542 Sigma-70 region 2 30 93 1.4E-10 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04620 7e61100326fb0696b989d75d94d46748 640 Pfam PF07980 SusD family 298 616 7.0E-32 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04620 7e61100326fb0696b989d75d94d46748 640 SUPERFAMILY SSF48452 582 616 2.96E-86 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04620 7e61100326fb0696b989d75d94d46748 640 SUPERFAMILY SSF48452 21 550 2.96E-86 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04620 7e61100326fb0696b989d75d94d46748 640 Gene3D G3DSA:1.25.40.10 432 523 1.4E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04620 7e61100326fb0696b989d75d94d46748 640 Gene3D G3DSA:1.25.40.10 218 332 1.4E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04620 7e61100326fb0696b989d75d94d46748 640 Pfam PF14322 Starch-binding associating with outer membrane 111 236 4.0E-17 T 21-04-2016 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 Pfam PF13424 Tetratricopeptide repeat 260 331 1.0E-8 T 21-04-2016 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 PANTHER PTHR24421 396 669 3.8E-32 T 21-04-2016 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SUPERFAMILY SSF48452 181 385 9.05E-19 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SMART SM00387 563 656 1.3E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 Gene3D G3DSA:3.30.565.10 502 523 1.6E-11 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 Gene3D G3DSA:3.30.565.10 561 654 1.6E-11 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SUPERFAMILY SSF55874 531 651 3.01E-15 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 564 654 2.0E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SUPERFAMILY SSF48452 53 167 6.64E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 Pfam PF07730 Histidine kinase 465 524 5.3E-9 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 Gene3D G3DSA:1.25.40.10 58 164 4.7E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SMART SM00028 220 253 440.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SMART SM00028 180 213 250.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SMART SM00028 135 168 0.33 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SMART SM00028 299 332 1.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SMART SM00028 260 293 12.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 SMART SM00028 55 88 130.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16005 5c6c0e11fa298a65167291ff040e5224 671 Gene3D G3DSA:1.25.40.10 180 399 1.7E-20 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02310 be58231e43c3f7b12823ddae01295dac 261 Gene3D G3DSA:3.40.50.1110 27 259 4.9E-75 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS02310 be58231e43c3f7b12823ddae01295dac 261 SUPERFAMILY SSF52266 27 248 6.5E-51 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS02310 be58231e43c3f7b12823ddae01295dac 261 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 32 210 6.3E-16 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS15200 112fafcd50efd468a909bba6ed48f823 154 SUPERFAMILY SSF54001 30 150 2.7E-35 T 21-04-2016 SPH21_RS15200 112fafcd50efd468a909bba6ed48f823 154 PANTHER PTHR21666 45 153 6.2E-27 T 21-04-2016 SPH21_RS15200 112fafcd50efd468a909bba6ed48f823 154 Gene3D G3DSA:3.90.1720.10 34 152 1.4E-38 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS15200 112fafcd50efd468a909bba6ed48f823 154 Pfam PF00877 NlpC/P60 family 47 148 7.1E-26 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 Hamap MF_00909 Cell division protein FtsZ [ftsZ]. 8 339 35.163 T 21-04-2016 IPR000158 Cell division protein FtsZ GO:0005525 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 SMART SM00864 12 204 1.2E-100 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 PRINTS PR00423 Cell division protein FtsZ signature 98 118 1.0E-44 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 PRINTS PR00423 Cell division protein FtsZ signature 211 232 1.0E-44 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 PRINTS PR00423 Cell division protein FtsZ signature 126 147 1.0E-44 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 PRINTS PR00423 Cell division protein FtsZ signature 188 210 1.0E-44 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 Gene3D G3DSA:3.30.1330.20 214 321 4.3E-40 T 21-04-2016 IPR018316 Tubulin/FtsZ, 2-layer sandwich domain SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 SMART SM00865 206 325 2.9E-38 T 21-04-2016 IPR018316 Tubulin/FtsZ, 2-layer sandwich domain SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 Gene3D G3DSA:3.40.50.1440 13 213 4.4E-88 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 ProSitePatterns PS01135 FtsZ protein signature 2. 97 118 - T 21-04-2016 IPR020805 Cell division protein FtsZ, conserved site GO:0005525|GO:0005737 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 TIGRFAM TIGR00065 ftsZ: cell division protein FtsZ 5 328 1.6E-116 T 21-04-2016 IPR000158 Cell division protein FtsZ GO:0005525 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 ProSitePatterns PS01134 FtsZ protein signature 1. 43 77 - T 21-04-2016 IPR020805 Cell division protein FtsZ, conserved site GO:0005525|GO:0005737 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 PANTHER PTHR30314:SF3 1 365 3.1E-158 T 21-04-2016 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 Pfam PF12327 FtsZ family, C-terminal domain 221 317 5.2E-23 T 21-04-2016 IPR024757 Cell division protein FtsZ, C-terminal SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 Pfam PF00091 Tubulin/FtsZ family, GTPase domain 13 172 9.1E-38 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 PANTHER PTHR30314 1 365 3.1E-158 T 21-04-2016 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 SUPERFAMILY SSF52490 4 205 2.75E-62 T 21-04-2016 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 SPH21_RS00255 b59a264be1aa1345969440e31694f0bb 565 SUPERFAMILY SSF55307 203 318 1.51E-34 T 21-04-2016 IPR008280 Tubulin/FtsZ, C-terminal SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 Pfam PF00072 Response regulator receiver domain 5 109 1.4E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 Gene3D G3DSA:3.40.50.2300 1 114 1.3E-26 T 21-04-2016 SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 Gene3D G3DSA:2.40.50.40 130 200 7.2E-19 T 21-04-2016 SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 SMART SM00850 139 232 4.4E-21 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 PANTHER PTHR26402 2 113 2.6E-30 T 21-04-2016 SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 Pfam PF04397 LytTr DNA-binding domain 141 231 1.2E-17 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 SMART SM00448 2 110 1.1E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22885 926bec416d6ef4fcb8772121fed071bf 235 SUPERFAMILY SSF52172 1 130 7.83E-29 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 Pfam PF17168 Domain of unknown function (DUF5127) 247 469 2.6E-59 T 21-04-2016 IPR033433 Domain of unknown function DUF5127 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 Pfam PF16334 Domain of unknown function (DUF4964) 23 90 1.4E-25 T 21-04-2016 IPR032515 Domain of unknown function DUF4964 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 PANTHER PTHR31987 232 823 9.5E-233 T 21-04-2016 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 PANTHER PTHR31987 1 87 9.5E-233 T 21-04-2016 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 PANTHER PTHR31987:SF1 232 823 9.5E-233 T 21-04-2016 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 PANTHER PTHR31987:SF1 1 87 9.5E-233 T 21-04-2016 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 Pfam PF08760 Domain of unknown function (DUF1793) 648 812 3.7E-56 T 21-04-2016 IPR014870 Domain of unknown function DUF1793 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 Pfam PF16335 Domain of unknown function (DUF4965) 474 642 7.7E-71 T 21-04-2016 IPR032514 Domain of unknown function DUF4965 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2 SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 SUPERFAMILY SSF49785 109 223 9.5E-9 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 Gene3D G3DSA:2.60.120.260 110 240 3.5E-8 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS04535 96eda2568456d75e9fb51fc718d72135 829 SUPERFAMILY SSF48208 522 701 1.53E-7 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 Gene3D G3DSA:1.20.1250.20 257 481 4.9E-23 T 21-04-2016 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 PANTHER PTHR23501 3 483 7.4E-111 T 21-04-2016 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 Pfam PF07690 Major Facilitator Superfamily 12 404 1.6E-54 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 Gene3D G3DSA:1.20.1250.20 9 186 1.4E-30 T 21-04-2016 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 PRINTS PR01036 Tetracycline resistance protein TetB signature 102 122 8.8E-10 T 21-04-2016 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 PRINTS PR01036 Tetracycline resistance protein TetB signature 297 321 8.8E-10 T 21-04-2016 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 PRINTS PR01036 Tetracycline resistance protein TetB signature 11 35 8.8E-10 T 21-04-2016 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 PRINTS PR01036 Tetracycline resistance protein TetB signature 132 156 8.8E-10 T 21-04-2016 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 8 417 1.8E-104 T 21-04-2016 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 SUPERFAMILY SSF103473 243 456 2.22E-70 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS18370 100448373786b366da4c14a8b8dc28cd 488 SUPERFAMILY SSF103473 5 190 2.22E-70 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 SUPERFAMILY SSF51011 465 542 1.52E-7 T 21-04-2016 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 Gene3D G3DSA:2.60.40.1180 464 542 4.3E-8 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 PANTHER PTHR10357:SF164 439 542 1.0E-138 T 21-04-2016 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 PANTHER PTHR10357:SF164 7 400 1.0E-138 T 21-04-2016 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 Pfam PF00128 Alpha amylase, catalytic domain 32 384 4.2E-71 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 Gene3D G3DSA:3.90.400.10 109 176 3.8E-19 T 21-04-2016 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 SUPERFAMILY SSF51445 8 325 5.52E-106 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 SUPERFAMILY SSF51445 353 458 5.52E-106 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 SMART SM00642 17 409 1.5E-72 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 PANTHER PTHR10357 439 542 1.0E-138 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 PANTHER PTHR10357 7 400 1.0E-138 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 Gene3D G3DSA:3.20.20.80 11 108 1.4E-84 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 Gene3D G3DSA:3.20.20.80 442 456 1.4E-84 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS18925 a3eb756871e7240b4515c996784a59c7 546 Gene3D G3DSA:3.20.20.80 184 409 1.4E-84 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS13085 39d8d9e410a90a9dd810ecb71d5f9d9f 317 Pfam PF03737 Demethylmenaquinone methyltransferase 80 240 3.4E-15 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS13085 39d8d9e410a90a9dd810ecb71d5f9d9f 317 SUPERFAMILY SSF89562 79 248 4.19E-17 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS13085 39d8d9e410a90a9dd810ecb71d5f9d9f 317 Gene3D G3DSA:3.50.30.40 67 250 4.0E-30 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 Gene3D G3DSA:3.30.70.920 73 148 6.9E-22 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 PANTHER PTHR30154:SF2 2 157 6.2E-49 T 21-04-2016 SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 Gene3D G3DSA:1.10.10.10 8 59 5.4E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 SUPERFAMILY SSF46785 9 70 7.86E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 SMART SM00344 10 117 1.5E-34 T 21-04-2016 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 SUPERFAMILY SSF54909 71 152 5.9E-18 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 Pfam PF01037 Lrp/AsnC ligand binding domain 77 148 1.2E-17 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 10 26 1.3E-8 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 37 56 1.3E-8 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 26 37 1.3E-8 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 PANTHER PTHR30154 2 157 6.2E-49 T 21-04-2016 SPH21_RS06440 0546d6d42fb7f9d570c51ec4cccc368d 157 Pfam PF13412 Winged helix-turn-helix DNA-binding 10 57 2.8E-12 T 21-04-2016 SPH21_RS25215 2ea10c42ce291b28073ad67d19d46599 543 SUPERFAMILY SSF48452 23 543 4.17E-103 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25215 2ea10c42ce291b28073ad67d19d46599 543 Gene3D G3DSA:1.25.40.10 397 489 2.5E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25215 2ea10c42ce291b28073ad67d19d46599 543 Gene3D G3DSA:1.25.40.10 217 334 2.5E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25215 2ea10c42ce291b28073ad67d19d46599 543 Pfam PF07980 SusD family 285 543 7.4E-32 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS25215 2ea10c42ce291b28073ad67d19d46599 543 Pfam PF14322 Starch-binding associating with outer membrane 27 233 1.3E-13 T 21-04-2016 SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 458 468 - T 21-04-2016 IPR023828 Peptidase S8, subtilisin, Ser-active site SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 PRINTS PR00723 Subtilisin serine protease family (S8) signature 60 79 2.1E-15 T 21-04-2016 IPR015500 Peptidase S8, subtilisin-related SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 PRINTS PR00723 Subtilisin serine protease family (S8) signature 282 295 2.1E-15 T 21-04-2016 IPR015500 Peptidase S8, subtilisin-related SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 PRINTS PR00723 Subtilisin serine protease family (S8) signature 457 473 2.1E-15 T 21-04-2016 IPR015500 Peptidase S8, subtilisin-related SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 Pfam PF00082 Subtilase family 62 493 9.3E-50 T 21-04-2016 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 Gene3D G3DSA:3.40.50.200 262 534 5.3E-79 T 21-04-2016 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 Gene3D G3DSA:3.40.50.200 27 86 5.3E-79 T 21-04-2016 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 286 296 - T 21-04-2016 IPR022398 Peptidase S8, subtilisin, His-active site SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 PANTHER PTHR10795 63 82 5.9E-45 T 21-04-2016 IPR015500 Peptidase S8, subtilisin-related SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 PANTHER PTHR10795 250 489 5.9E-45 T 21-04-2016 IPR015500 Peptidase S8, subtilisin-related SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 PANTHER PTHR10795:SF419 63 82 5.9E-45 T 21-04-2016 SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 PANTHER PTHR10795:SF419 250 489 5.9E-45 T 21-04-2016 SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 SUPERFAMILY SSF52743 275 535 2.67E-66 T 21-04-2016 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SPH21_RS02820 22344738a10a2169712b6469ed578ea5 539 SUPERFAMILY SSF52743 47 118 2.67E-66 T 21-04-2016 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 211 240 9.1E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 PANTHER PTHR11532:SF57 1 372 2.9E-244 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 PANTHER PTHR11532:SF57 479 1029 2.9E-244 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Pfam PF13715 CarboxypepD_reg-like domain 42 123 1.3E-12 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 SUPERFAMILY SSF49464 40 121 4.84E-10 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Gene3D G3DSA:2.40.170.20 325 797 8.9E-50 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Gene3D G3DSA:2.40.170.20 871 921 8.9E-50 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Gene3D G3DSA:2.40.170.20 955 1031 8.9E-50 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Gene3D G3DSA:2.40.170.20 237 253 8.9E-50 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Gene3D G3DSA:2.170.130.10 132 236 3.5E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Pfam PF07715 TonB-dependent Receptor Plug Domain 131 234 1.1E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 40 1031 5.2E-255 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 SUPERFAMILY SSF56935 945 1031 1.01E-85 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 SUPERFAMILY SSF56935 119 257 1.01E-85 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 SUPERFAMILY SSF56935 439 790 1.01E-85 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 SUPERFAMILY SSF56935 871 906 1.01E-85 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 SUPERFAMILY SSF56935 316 406 1.01E-85 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 Gene3D G3DSA:2.60.40.1120 41 131 1.1E-6 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 PANTHER PTHR11532 1 372 2.9E-244 T 21-04-2016 SPH21_RS14445 2e8907b84259dbcee3c507b93e42a14e 1031 PANTHER PTHR11532 479 1029 2.9E-244 T 21-04-2016 SPH21_RS13000 5ec41c4c32a8acbd8f1eaf0f30ef8b64 322 PANTHER PTHR32196:SF21 8 322 1.1E-126 T 21-04-2016 SPH21_RS13000 5ec41c4c32a8acbd8f1eaf0f30ef8b64 322 Pfam PF02653 Branched-chain amino acid transport system / permease component 39 312 3.1E-49 T 21-04-2016 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SPH21_RS13000 5ec41c4c32a8acbd8f1eaf0f30ef8b64 322 PANTHER PTHR32196 8 322 1.1E-126 T 21-04-2016 SPH21_RS01420 41143a884bf7a1b6a415b30f5e0578da 129 Pfam PF00403 Heavy-metal-associated domain 34 86 1.6E-6 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01420 41143a884bf7a1b6a415b30f5e0578da 129 Gene3D G3DSA:3.30.70.100 22 86 1.4E-11 T 21-04-2016 SPH21_RS01420 41143a884bf7a1b6a415b30f5e0578da 129 SUPERFAMILY SSF55008 26 93 1.15E-10 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 SMART SM00382 474 714 0.012 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 SMART SM00382 23 411 3.0 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 PANTHER PTHR32282 1 748 0.0 T 21-04-2016 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 SUPERFAMILY SSF52540 282 416 1.19E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:1.10.8.280 150 256 2.2E-7 T 21-04-2016 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 SUPERFAMILY SSF52540 4 153 1.19E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Pfam PF00005 ABC transporter 465 668 1.4E-11 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 ProSitePatterns PS00211 ABC transporters family signature. 334 348 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:1.20.1580.10 92 149 3.2E-38 T 21-04-2016 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:1.20.1580.10 515 631 2.9E-33 T 21-04-2016 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:1.20.1580.10 257 324 3.2E-38 T 21-04-2016 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 PANTHER PTHR32282:SF10 1 748 0.0 T 21-04-2016 SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:3.40.50.300 4 51 3.3E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:3.40.50.300 632 748 6.9E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:3.40.50.300 444 514 6.9E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 Gene3D G3DSA:3.40.50.300 325 440 3.3E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21555 8087873f1634d9444a73504857d3d05d 750 SUPERFAMILY SSF52540 459 721 1.01E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 PANTHER PTHR21089:SF3 95 361 6.1E-60 T 21-04-2016 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 Gene3D G3DSA:3.40.50.720 184 341 3.4E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 ProSitePatterns PS00747 Glutamyl-tRNA reductase signature. 103 126 - T 21-04-2016 IPR018214 Glutamyl-tRNA reductase, conserved site GO:0008883|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 Pfam PF01488 Shikimate / quinate 5-dehydrogenase 184 308 1.6E-26 T 21-04-2016 IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 SUPERFAMILY SSF69742 3 162 3.53E-29 T 21-04-2016 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 PANTHER PTHR21089 95 361 6.1E-60 T 21-04-2016 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 Pfam PF05201 Glutamyl-tRNAGlu reductase, N-terminal domain 7 160 5.0E-31 T 21-04-2016 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 TIGRFAM TIGR01035 hemA: glutamyl-tRNA reductase 6 404 4.7E-75 T 21-04-2016 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 SUPERFAMILY SSF51735 167 316 4.15E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 SUPERFAMILY SSF69075 320 402 2.88E-5 T 21-04-2016 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 Pfam PF00745 Glutamyl-tRNAGlu reductase, dimerisation domain 323 407 3.5E-6 T 21-04-2016 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 PIRSF PIRSF000445 2 413 7.1E-90 T 21-04-2016 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS25590 c7fc606fa1552b7bc4a7681dc0a13a0e 414 Hamap MF_00087 Glutamyl-tRNA reductase [hemA]. 3 412 20.225 T 21-04-2016 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188|UniPathway: UPA00251 SPH21_RS00075 05c05fddbbcb1cafe0a28946a9df368b 146 TIGRFAM TIGR01120 rpiB: ribose 5-phosphate isomerase B 6 144 3.3E-46 T 21-04-2016 IPR004785 Ribose 5-phosphate isomerase B GO:0004751|GO:0006098 SPH21_RS00075 05c05fddbbcb1cafe0a28946a9df368b 146 PIRSF PIRSF005384 4 146 8.9E-53 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS00075 05c05fddbbcb1cafe0a28946a9df368b 146 TIGRFAM TIGR00689 rpiB_lacA_lacB: sugar-phosphate isomerase, RpiB/LacA/LacB family 6 144 2.1E-49 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS00075 05c05fddbbcb1cafe0a28946a9df368b 146 Gene3D G3DSA:3.40.1400.10 1 144 4.4E-60 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS00075 05c05fddbbcb1cafe0a28946a9df368b 146 Pfam PF02502 Ribose/Galactose Isomerase 6 143 4.6E-55 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS00075 05c05fddbbcb1cafe0a28946a9df368b 146 SUPERFAMILY SSF89623 4 144 1.1E-52 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS00075 05c05fddbbcb1cafe0a28946a9df368b 146 PANTHER PTHR30345 1 144 9.5E-61 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS01730 deb41a73d4167a4d34747e0913c5d9c2 127 Gene3D G3DSA:3.30.530.20 3 116 1.2E-15 T 21-04-2016 IPR023393 START-like domain SPH21_RS01730 deb41a73d4167a4d34747e0913c5d9c2 127 SUPERFAMILY SSF55961 8 126 7.33E-19 T 21-04-2016 SPH21_RS01730 deb41a73d4167a4d34747e0913c5d9c2 127 PANTHER PTHR13009:SF8 12 124 2.1E-28 T 21-04-2016 SPH21_RS01730 deb41a73d4167a4d34747e0913c5d9c2 127 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 12 120 3.8E-17 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS01730 deb41a73d4167a4d34747e0913c5d9c2 127 PANTHER PTHR13009 12 124 2.1E-28 T 21-04-2016 SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 PANTHER PTHR11361 9 438 3.7E-34 T 21-04-2016 SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 Gene3D G3DSA:1.10.1420.10 21 215 4.0E-10 T 21-04-2016 SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 Gene3D G3DSA:3.40.50.300 244 450 9.8E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 SUPERFAMILY SSF52540 245 454 7.91E-32 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 Pfam PF05192 MutS domain III 25 229 1.4E-7 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 SUPERFAMILY SSF48334 23 178 3.53E-8 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 SMART SM00534 274 459 3.8E-12 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS25150 1005eb1ceb472db3068eb3830c9fb3f5 465 Pfam PF00488 MutS domain V 278 441 9.6E-28 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS17920 7e482c96096532419753577ca0538803 461 SUPERFAMILY SSF56954 3 445 7.85E-46 T 21-04-2016 SPH21_RS17920 7e482c96096532419753577ca0538803 461 Pfam PF02321 Outer membrane efflux protein 34 216 1.0E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS17920 7e482c96096532419753577ca0538803 461 Pfam PF02321 Outer membrane efflux protein 267 444 1.6E-17 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS17920 7e482c96096532419753577ca0538803 461 Gene3D G3DSA:1.20.1600.10 23 442 1.3E-38 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 302 332 5.0E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Pfam PF07660 Secretin and TonB N terminus short domain 69 120 4.3E-7 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Gene3D G3DSA:2.60.40.1120 132 216 2.5E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 SUPERFAMILY SSF56935 407 475 2.71E-99 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 SUPERFAMILY SSF56935 212 354 2.71E-99 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 SUPERFAMILY SSF56935 511 862 2.71E-99 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 SUPERFAMILY SSF56935 1025 1088 2.71E-99 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 SUPERFAMILY SSF56935 946 989 2.71E-99 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 SMART SM00965 69 120 2.2E-5 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Pfam PF07715 TonB-dependent Receptor Plug Domain 222 326 6.2E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 131 1116 3.9E-282 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Gene3D G3DSA:2.40.170.20 954 979 2.7E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Gene3D G3DSA:2.40.170.20 502 872 2.7E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Gene3D G3DSA:2.40.170.20 327 346 2.7E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Gene3D G3DSA:2.40.170.20 1014 1116 2.7E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Gene3D G3DSA:2.40.170.20 406 470 2.7E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Pfam PF13715 CarboxypepD_reg-like domain 132 214 1.9E-17 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 Gene3D G3DSA:2.170.130.10 217 326 2.4E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 PANTHER PTHR11532 125 475 8.8E-275 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 PANTHER PTHR11532 545 1114 8.8E-275 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 PANTHER PTHR11532:SF57 125 475 8.8E-275 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 PANTHER PTHR11532:SF57 545 1114 8.8E-275 T 21-04-2016 SPH21_RS13825 17f138c30aa3229f37c858178bf45b39 1116 SUPERFAMILY SSF49464 130 212 1.28E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS26435 eebe22fd0114e7df1eef27807ecef1b4 524 PANTHER PTHR10681 362 502 2.4E-13 T 21-04-2016 SPH21_RS26435 eebe22fd0114e7df1eef27807ecef1b4 524 PANTHER PTHR10681:SF68 362 502 2.4E-13 T 21-04-2016 SPH21_RS26435 eebe22fd0114e7df1eef27807ecef1b4 524 Pfam PF13905 Thioredoxin-like 406 502 9.1E-16 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26435 eebe22fd0114e7df1eef27807ecef1b4 524 Gene3D G3DSA:3.40.30.10 374 523 1.0E-27 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26435 eebe22fd0114e7df1eef27807ecef1b4 524 SUPERFAMILY SSF52833 386 504 9.74E-20 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 PANTHER PTHR24421 142 156 5.1E-25 T 21-04-2016 SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 PANTHER PTHR24421 442 648 5.1E-25 T 21-04-2016 SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 Gene3D G3DSA:3.30.565.10 551 647 9.7E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 PANTHER PTHR24421:SF1 142 156 5.1E-25 T 21-04-2016 SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 PANTHER PTHR24421:SF1 442 648 5.1E-25 T 21-04-2016 SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 SMART SM00387 553 647 1.4E-10 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 SUPERFAMILY SSF55874 541 645 2.88E-16 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 Pfam PF07730 Histidine kinase 447 505 2.7E-6 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS20840 33c99e47a8d88264ceb02139a4d2ac46 653 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 555 646 1.7E-8 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 Gene3D G3DSA:3.40.50.1820 5 272 2.4E-62 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 216 230 2.3E-11 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 91 104 2.3E-11 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 47 62 2.3E-11 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PRINTS PR00412 Epoxide hydrolase signature 27 45 7.5E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PRINTS PR00412 Epoxide hydrolase signature 47 62 7.5E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PRINTS PR00412 Epoxide hydrolase signature 248 270 7.5E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PRINTS PR00412 Epoxide hydrolase signature 214 230 7.5E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PANTHER PTHR10992 3 273 1.2E-113 T 21-04-2016 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 PANTHER PTHR10992:SF859 3 273 1.2E-113 T 21-04-2016 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 Pfam PF00561 alpha/beta hydrolase fold 21 253 8.1E-22 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS24580 5fa1e330ca66bf8c7053522cd9e93e20 273 SUPERFAMILY SSF53474 2 272 5.31E-60 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS21475 b125ae2a54b23296fa9df79f7cb6ab0d 202 PANTHER PTHR24567 44 199 4.6E-15 T 21-04-2016 SPH21_RS21475 b125ae2a54b23296fa9df79f7cb6ab0d 202 SUPERFAMILY SSF51206 26 140 6.55E-21 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS21475 b125ae2a54b23296fa9df79f7cb6ab0d 202 Pfam PF00027 Cyclic nucleotide-binding domain 39 124 2.1E-8 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS21475 b125ae2a54b23296fa9df79f7cb6ab0d 202 PANTHER PTHR24567:SF33 44 199 4.6E-15 T 21-04-2016 SPH21_RS21475 b125ae2a54b23296fa9df79f7cb6ab0d 202 Gene3D G3DSA:2.60.120.10 12 143 4.4E-32 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS11680 67d6990628910737b55cb3cc3b5d8524 126 PANTHER PTHR33204 6 112 1.7E-38 T 21-04-2016 SPH21_RS11680 67d6990628910737b55cb3cc3b5d8524 126 Gene3D G3DSA:1.10.10.10 6 117 4.9E-41 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11680 67d6990628910737b55cb3cc3b5d8524 126 Pfam PF01638 HxlR-like helix-turn-helix 27 114 2.4E-31 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS11680 67d6990628910737b55cb3cc3b5d8524 126 SUPERFAMILY SSF46785 15 113 1.4E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11680 67d6990628910737b55cb3cc3b5d8524 126 PANTHER PTHR33204:SF8 6 112 1.7E-38 T 21-04-2016 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PIRSF PIRSF000109 1 471 5.4E-188 T 21-04-2016 IPR006113 6-phosphogluconate dehydrogenase, decarboxylating GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 SMART SM01350 179 471 7.7E-164 T 21-04-2016 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PANTHER PTHR11811:SF25 1 471 9.4E-241 T 21-04-2016 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 Gene3D G3DSA:1.20.5.320 439 470 5.9E-20 T 21-04-2016 IPR012284 6-phosphogluconate dehydrogenase, domain 3 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PANTHER PTHR11811 1 471 9.4E-241 T 21-04-2016 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 SUPERFAMILY SSF51735 4 175 8.74E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 120 145 7.9E-76 T 21-04-2016 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 67 96 7.9E-76 T 21-04-2016 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 168 196 7.9E-76 T 21-04-2016 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 250 277 7.9E-76 T 21-04-2016 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 360 382 7.9E-76 T 21-04-2016 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 4 27 7.9E-76 T 21-04-2016 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 SUPERFAMILY SSF48179 178 470 3.4E-108 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 6 164 1.8E-45 T 21-04-2016 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 Gene3D G3DSA:1.10.1040.10 181 437 1.3E-93 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 TIGRFAM TIGR00873 gnd: 6-phosphogluconate dehydrogenase (decarboxylating) 5 470 3.6E-179 T 21-04-2016 IPR006113 6-phosphogluconate dehydrogenase, decarboxylating GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 Pfam PF00393 6-phosphogluconate dehydrogenase, C-terminal domain 179 470 8.7E-116 T 21-04-2016 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|UniPathway: UPA00115 SPH21_RS21175 6b85047657a0114a0fc1250b03a571c4 471 Gene3D G3DSA:3.40.50.720 3 179 1.8E-51 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 Pfam PF13488 Glycine zipper 41 85 4.1E-11 T 21-04-2016 SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 SUPERFAMILY SSF103088 102 215 7.46E-37 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 Gene3D G3DSA:3.30.1330.60 102 216 2.9E-40 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 Pfam PF00691 OmpA family 114 209 3.6E-23 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 PRINTS PR01021 OMPA domain signature 160 176 1.5E-17 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 PRINTS PR01021 OMPA domain signature 145 160 1.5E-17 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 PRINTS PR01021 OMPA domain signature 115 137 1.5E-17 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS07490 196b3ea19fe4080536bbe858cd9035f2 231 PANTHER PTHR30128 93 219 5.5E-43 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 Gene3D G3DSA:3.50.50.60 343 397 2.5E-45 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 Gene3D G3DSA:3.50.50.60 1 192 2.5E-45 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 TIGRFAM TIGR00275 TIGR00275: flavoprotein, HI0933 family 5 396 4.2E-111 T 21-04-2016 IPR004792 Conserved hypothetical protein CHP00275, flavoprotein HI0933-like SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 SUPERFAMILY SSF51905 341 398 3.33E-49 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 SUPERFAMILY SSF51905 1 194 3.33E-49 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 4 26 4.3E-6 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 161 170 4.3E-6 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 PANTHER PTHR10617 334 396 1.3E-97 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 PANTHER PTHR10617 1 298 1.3E-97 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 Gene3D G3DSA:2.40.30.10 195 276 3.7E-26 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 SUPERFAMILY SSF160996 195 343 5.62E-34 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 Pfam PF03486 HI0933-like protein 3 396 2.3E-120 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 PANTHER PTHR10617:SF103 334 396 1.3E-97 T 21-04-2016 SPH21_RS16855 9fe398cacb67394b21d59acf2116dbfd 398 PANTHER PTHR10617:SF103 1 298 1.3E-97 T 21-04-2016 SPH21_RS26425 d59b673a7252c111d8a792dad1b143f4 373 PANTHER PTHR34220:SF1 157 373 1.2E-44 T 21-04-2016 SPH21_RS26425 d59b673a7252c111d8a792dad1b143f4 373 PANTHER PTHR34220 157 373 1.2E-44 T 21-04-2016 SPH21_RS26425 d59b673a7252c111d8a792dad1b143f4 373 Pfam PF06580 Histidine kinase 190 267 3.2E-22 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS10190 5d60615536695e8960b1db62db64a4d7 303 SUPERFAMILY SSF53448 5 222 8.04E-32 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS10190 5d60615536695e8960b1db62db64a4d7 303 PANTHER PTHR22916 1 302 1.9E-67 T 21-04-2016 SPH21_RS10190 5d60615536695e8960b1db62db64a4d7 303 Pfam PF00535 Glycosyl transferase family 2 7 171 1.6E-12 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS10190 5d60615536695e8960b1db62db64a4d7 303 PANTHER PTHR22916:SF22 1 302 1.9E-67 T 21-04-2016 SPH21_RS10190 5d60615536695e8960b1db62db64a4d7 303 Gene3D G3DSA:3.90.550.10 7 222 2.9E-25 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS07635 977f54b33d059f9b75478bdccf387ad0 207 Pfam PF00005 ABC transporter 19 159 4.3E-21 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS07635 977f54b33d059f9b75478bdccf387ad0 207 Gene3D G3DSA:3.40.50.300 3 202 2.0E-34 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07635 977f54b33d059f9b75478bdccf387ad0 207 PANTHER PTHR24220:SF563 4 203 5.0E-33 T 21-04-2016 SPH21_RS07635 977f54b33d059f9b75478bdccf387ad0 207 PANTHER PTHR24220 4 203 5.0E-33 T 21-04-2016 SPH21_RS07635 977f54b33d059f9b75478bdccf387ad0 207 SUPERFAMILY SSF52540 3 203 4.07E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07635 977f54b33d059f9b75478bdccf387ad0 207 SMART SM00382 27 205 2.7E-7 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS12325 e4a701c2d78b16b4fe25fedde6fb440d 176 PANTHER PTHR10204:SF42 1 176 2.9E-52 T 21-04-2016 SPH21_RS12325 e4a701c2d78b16b4fe25fedde6fb440d 176 SUPERFAMILY SSF52218 1 176 2.86E-38 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS12325 e4a701c2d78b16b4fe25fedde6fb440d 176 PANTHER PTHR10204 1 176 2.9E-52 T 21-04-2016 SPH21_RS12325 e4a701c2d78b16b4fe25fedde6fb440d 176 Pfam PF02525 Flavodoxin-like fold 1 170 3.5E-38 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS12325 e4a701c2d78b16b4fe25fedde6fb440d 176 Gene3D G3DSA:3.40.50.360 1 172 7.0E-38 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 ProSitePatterns PS00211 ABC transporters family signature. 130 144 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 Pfam PF13732 Domain of unknown function (DUF4162) 211 297 3.5E-14 T 21-04-2016 IPR025302 Domain of unknown function DUF4162 SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 PANTHER PTHR24220:SF450 3 224 2.8E-93 T 21-04-2016 SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 SUPERFAMILY SSF52540 2 220 3.06E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 Pfam PF00005 ABC transporter 17 157 9.5E-29 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 PANTHER PTHR24220 3 224 2.8E-93 T 21-04-2016 SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 Gene3D G3DSA:3.40.50.300 1 222 5.1E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15515 c4c8d495f069833cec14c0e7cfe6bd49 303 SMART SM00382 26 215 2.2E-12 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 SMART SM00493 1 131 6.7E-15 T 21-04-2016 IPR006171 Toprim domain SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 Gene3D G3DSA:1.10.290.10 278 400 7.9E-31 T 21-04-2016 IPR013826 DNA topoisomerase, type IA, central region, subdomain 3 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 Gene3D G3DSA:1.10.460.10 460 591 2.1E-55 T 21-04-2016 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 Gene3D G3DSA:1.10.460.10 161 216 2.1E-55 T 21-04-2016 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 TIGRFAM TIGR01056 topB: DNA topoisomerase III 1 614 2.5E-155 T 21-04-2016 IPR005738 DNA topoisomerase III GO:0003677|GO:0003916|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 SUPERFAMILY SSF56712 1 591 4.32E-161 T 21-04-2016 IPR023405 DNA topoisomerase, type IA, core domain SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 388 404 3.0E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 309 318 3.0E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 506 520 3.0E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 105 118 3.0E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 192 210 3.0E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PANTHER PTHR11390:SF21 506 592 2.2E-155 T 21-04-2016 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PANTHER PTHR11390:SF21 1 70 2.2E-155 T 21-04-2016 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PANTHER PTHR11390:SF21 86 489 2.2E-155 T 21-04-2016 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 SMART SM00436 131 222 3.3E-32 T 21-04-2016 IPR003601 DNA topoisomerase, type IA, domain 2 GO:0003677|GO:0003916|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PANTHER PTHR11390 506 592 2.2E-155 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PANTHER PTHR11390 1 70 2.2E-155 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 PANTHER PTHR11390 86 489 2.2E-155 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 Pfam PF13342 C-terminal repeat of topoisomerase 629 687 8.2E-19 T 21-04-2016 IPR025589 Topoisomerase C-terminal repeat SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 Pfam PF01131 DNA topoisomerase 158 577 1.1E-117 T 21-04-2016 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 Gene3D G3DSA:3.40.50.140 1 158 3.4E-44 T 21-04-2016 IPR006171 Toprim domain SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 SMART SM00437 267 543 1.9E-65 T 21-04-2016 IPR003602 DNA topoisomerase, type IA, DNA-binding domain GO:0003677|GO:0003916|GO:0006265 SPH21_RS17965 1787a137cb99311c60f4d64095751ac1 694 Pfam PF01751 Toprim domain 3 139 1.7E-14 T 21-04-2016 IPR006171 Toprim domain SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 Pfam PF10996 Beta-Casp domain 252 377 1.6E-23 T 21-04-2016 IPR022712 Beta-Casp domain SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 PANTHER PTHR11203:SF11 1 462 1.9E-109 T 21-04-2016 SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 SMART SM00849 13 247 5.5E-13 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 PANTHER PTHR11203 1 462 1.9E-109 T 21-04-2016 SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 SUPERFAMILY SSF56281 1 461 2.76E-112 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 Pfam PF07521 Zn-dependent metallo-hydrolase RNA specificity domain 392 454 3.4E-8 T 21-04-2016 IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 SMART SM01027 252 377 2.0E-42 T 21-04-2016 IPR022712 Beta-Casp domain SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 Gene3D G3DSA:3.60.15.10 1 92 8.3E-48 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 Gene3D G3DSA:3.60.15.10 128 261 8.3E-48 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12520 bee9a97008419222cf1cfbdc8e24b9ae 462 Pfam PF16661 Metallo-beta-lactamase superfamily domain 18 167 4.3E-12 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Gene3D G3DSA:1.10.1780.10 1 125 1.9E-11 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 206 339 6.2E-14 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Gene3D G3DSA:1.10.8.60 738 812 1.1E-20 T 21-04-2016 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Pfam PF07724 AAA domain (Cdc48 subfamily) 558 720 1.1E-39 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 SMART SM01086 726 815 4.0E-18 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Gene3D G3DSA:1.10.8.60 348 426 1.1E-17 T 21-04-2016 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 SMART SM00382 202 344 4.5E-14 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 SMART SM00382 558 712 1.5E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 636 654 1.2E-32 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 562 580 1.2E-32 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 669 683 1.2E-32 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 607 625 1.2E-32 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 SUPERFAMILY SSF52540 165 428 2.51E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Gene3D G3DSA:3.40.50.300 514 737 4.9E-45 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 SUPERFAMILY SSF52540 507 806 3.02E-64 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 PANTHER PTHR11638 1 806 4.7E-244 T 21-04-2016 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 729 806 1.8E-18 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 PANTHER PTHR11638:SF18 1 806 4.7E-244 T 21-04-2016 SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 Gene3D G3DSA:3.40.50.300 165 344 1.5E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23885 362096a9977471eeae13eb1d6954ea59 828 SUPERFAMILY SSF81923 7 132 8.24E-12 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS11770 7666ed853bdce6b4f251f1cab4c53e4c 197 Hamap MF_01930 Phosphoribosylglycinamide formyltransferase [purN]. 4 189 25.552 T 21-04-2016 IPR004607 Phosphoribosylglycinamide formyltransferase GO:0004644|GO:0006189 KEGG: 00230+2.1.2.2|KEGG: 00670+2.1.2.2|MetaCyc: PWY-6121|MetaCyc: PWY-6613|UniPathway: UPA00074 SPH21_RS11770 7666ed853bdce6b4f251f1cab4c53e4c 197 TIGRFAM TIGR00639 PurN: phosphoribosylglycinamide formyltransferase 3 189 3.2E-48 T 21-04-2016 IPR004607 Phosphoribosylglycinamide formyltransferase GO:0004644|GO:0006189 KEGG: 00230+2.1.2.2|KEGG: 00670+2.1.2.2|MetaCyc: PWY-6121|MetaCyc: PWY-6613|UniPathway: UPA00074 SPH21_RS11770 7666ed853bdce6b4f251f1cab4c53e4c 197 PANTHER PTHR10520 1 194 8.3E-66 T 21-04-2016 SPH21_RS11770 7666ed853bdce6b4f251f1cab4c53e4c 197 Gene3D G3DSA:3.40.50.170 2 189 3.8E-54 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS11770 7666ed853bdce6b4f251f1cab4c53e4c 197 SUPERFAMILY SSF53328 3 188 1.7E-49 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS11770 7666ed853bdce6b4f251f1cab4c53e4c 197 PANTHER PTHR10520:SF9 1 194 8.3E-66 T 21-04-2016 SPH21_RS11770 7666ed853bdce6b4f251f1cab4c53e4c 197 Pfam PF00551 Formyl transferase 3 183 3.4E-44 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 SUPERFAMILY SSF46548 282 394 1.05E-23 T 21-04-2016 IPR009051 Alpha-helical ferredoxin GO:0051536 SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 365 376 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 300 311 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 PANTHER PTHR11921:SF22 101 431 1.7E-49 T 21-04-2016 SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 PANTHER PTHR11921 101 431 1.7E-49 T 21-04-2016 SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 Pfam PF13187 4Fe-4S dicluster domain 300 378 3.9E-11 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 SUPERFAMILY SSF103501 5 250 1.14E-13 T 21-04-2016 IPR023234 NarG-like domain SPH21_RS11650 48156973d40754ba660f09c2186b8c37 431 Gene3D G3DSA:1.10.1060.10 255 396 4.0E-33 T 21-04-2016 SPH21_RS10670 efbc0b65816bb186969b5d55c2a72a34 146 Gene3D G3DSA:3.40.50.2300 29 143 1.2E-29 T 21-04-2016 SPH21_RS10670 efbc0b65816bb186969b5d55c2a72a34 146 SUPERFAMILY SSF52172 29 144 4.98E-29 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10670 efbc0b65816bb186969b5d55c2a72a34 146 Pfam PF00072 Response regulator receiver domain 32 141 4.8E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10670 efbc0b65816bb186969b5d55c2a72a34 146 PANTHER PTHR26402 30 144 2.8E-29 T 21-04-2016 SPH21_RS10670 efbc0b65816bb186969b5d55c2a72a34 146 SMART SM00448 30 141 1.1E-25 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 ProSitePatterns PS00564 Argininosuccinate synthase signature 1. 8 16 - T 21-04-2016 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 TIGRFAM TIGR00032 argG: argininosuccinate synthase 4 392 4.4E-87 T 21-04-2016 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 Pfam PF00764 Arginosuccinate synthase 6 389 1.8E-87 T 21-04-2016 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 PANTHER PTHR11587:SF2 2 394 4.5E-113 T 21-04-2016 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 SUPERFAMILY SSF69864 173 393 5.76E-60 T 21-04-2016 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 Gene3D G3DSA:3.90.1260.10 174 394 1.3E-56 T 21-04-2016 IPR024074 Argininosuccinate synthetase, catalytic/multimerisation domain body GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 Gene3D G3DSA:3.40.50.620 3 173 2.1E-40 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 PANTHER PTHR11587 2 394 4.5E-113 T 21-04-2016 SPH21_RS05080 c2356e50bf8566c5266f6c45d17ae9cb 395 SUPERFAMILY SSF52402 2 187 3.09E-38 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 222 3.4E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 25 1073 7.1E-223 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Gene3D G3DSA:2.40.170.20 341 405 1.7E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Gene3D G3DSA:2.40.170.20 904 929 1.7E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Gene3D G3DSA:2.40.170.20 977 1073 1.7E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Gene3D G3DSA:2.40.170.20 226 241 1.7E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Gene3D G3DSA:2.40.170.20 454 838 1.7E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Gene3D G3DSA:2.60.40.1120 25 115 1.0E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 198 228 4.8E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 SUPERFAMILY SSF49464 25 105 1.7E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 PANTHER PTHR11532 493 1071 4.0E-197 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 PANTHER PTHR11532 328 405 4.0E-197 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 PANTHER PTHR11532 1 301 4.0E-197 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Gene3D G3DSA:2.170.130.10 116 225 2.9E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 SUPERFAMILY SSF56935 894 939 1.06E-92 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 SUPERFAMILY SSF56935 480 831 1.06E-92 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 SUPERFAMILY SSF56935 981 1073 1.06E-92 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 SUPERFAMILY SSF56935 103 245 1.06E-92 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 SUPERFAMILY SSF56935 332 420 1.06E-92 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 PANTHER PTHR11532:SF57 493 1071 4.0E-197 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 PANTHER PTHR11532:SF57 328 405 4.0E-197 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 PANTHER PTHR11532:SF57 1 301 4.0E-197 T 21-04-2016 SPH21_RS05385 13b6690d0ac5f23edd4f50bada07b618 1073 Pfam PF13715 CarboxypepD_reg-like domain 26 107 6.9E-17 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 ProSitePatterns PS00211 ABC transporters family signature. 478 492 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 ProSitePatterns PS00211 ABC transporters family signature. 820 834 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:3.40.50.300 10 60 5.8E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:3.40.50.300 811 930 2.1E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:3.40.50.300 469 585 5.8E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:3.40.50.300 602 660 2.1E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:1.20.1580.10 101 138 2.8E-47 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:1.20.1580.10 261 294 2.8E-47 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:1.20.1580.10 398 468 2.8E-47 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Pfam PF00005 ABC transporter 612 851 1.9E-7 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 PANTHER PTHR32282 9 192 0.0 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 PANTHER PTHR32282 213 928 0.0 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 TIGRFAM TIGR00630 uvra: excinuclease ABC subunit A 13 915 0.0 T 21-04-2016 IPR004602 UvrABC system subunit A GO:0006289|GO:0009380|GO:0009381 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 SUPERFAMILY SSF52540 603 902 6.97E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:3.30.1490.20 214 258 3.1E-11 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:3.30.1490.20 140 162 3.1E-11 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 SUPERFAMILY SSF52540 17 213 9.91E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:1.10.8.280 296 397 1.5E-18 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 Gene3D G3DSA:1.20.1580.10 684 810 1.8E-44 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 PANTHER PTHR32282:SF2 9 192 0.0 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 PANTHER PTHR32282:SF2 213 928 0.0 T 21-04-2016 SPH21_RS02750 faa9b549d7c5dec4419e3806939f87bf 931 SUPERFAMILY SSF52540 421 560 9.91E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 SUPERFAMILY SSF55909 3 60 1.18E-5 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 SUPERFAMILY SSF55909 98 475 1.96E-54 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 Pfam PF02274 Amidinotransferase 147 472 2.8E-45 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737:SF13 354 425 1.4E-45 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737:SF13 448 476 1.4E-45 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737:SF13 163 314 1.4E-45 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737:SF13 5 78 1.4E-45 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PRINTS PR01466 Bacterial arginine deiminase signature 191 206 5.8E-14 T 21-04-2016 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PRINTS PR01466 Bacterial arginine deiminase signature 163 181 5.8E-14 T 21-04-2016 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PRINTS PR01466 Bacterial arginine deiminase signature 3 23 5.8E-14 T 21-04-2016 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737 354 425 1.4E-45 T 21-04-2016 IPR033199 Dimethylarginine dimethylaminohydrolase/arginine deiminase KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737 448 476 1.4E-45 T 21-04-2016 IPR033199 Dimethylarginine dimethylaminohydrolase/arginine deiminase KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737 163 314 1.4E-45 T 21-04-2016 IPR033199 Dimethylarginine dimethylaminohydrolase/arginine deiminase KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 PANTHER PTHR12737 5 78 1.4E-45 T 21-04-2016 IPR033199 Dimethylarginine dimethylaminohydrolase/arginine deiminase KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 Gene3D G3DSA:3.75.10.10 5 69 1.7E-96 T 21-04-2016 SPH21_RS14965 1211dd6807ab565cbaef8e00f36b3d54 476 Gene3D G3DSA:3.75.10.10 163 473 1.7E-96 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00458 Haem peroxidase superfamily signature 92 106 2.4E-15 T 21-04-2016 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00458 Haem peroxidase superfamily signature 152 169 2.4E-15 T 21-04-2016 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00458 Haem peroxidase superfamily signature 339 354 2.4E-15 T 21-04-2016 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00458 Haem peroxidase superfamily signature 170 182 2.4E-15 T 21-04-2016 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 SUPERFAMILY SSF48113 25 450 4.39E-154 T 21-04-2016 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 SUPERFAMILY SSF48113 451 756 2.21E-115 T 21-04-2016 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Gene3D G3DSA:1.10.420.10 272 295 1.6E-46 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Gene3D G3DSA:1.10.420.10 331 428 1.6E-46 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PANTHER PTHR30555:SF0 230 757 0.0 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PANTHER PTHR30555:SF0 1 206 0.0 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Gene3D G3DSA:1.10.520.10 735 756 8.6E-65 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Gene3D G3DSA:1.10.520.10 453 609 8.6E-65 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Gene3D G3DSA:1.10.520.10 49 192 2.8E-74 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Gene3D G3DSA:1.10.520.10 248 271 2.8E-74 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 288 311 1.7E-55 T 21-04-2016 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 28 50 1.7E-55 T 21-04-2016 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 54 67 1.7E-55 T 21-04-2016 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 69 94 1.7E-55 T 21-04-2016 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 501 527 1.7E-55 T 21-04-2016 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 ProSitePatterns PS00435 Peroxidases proximal heme-ligand signature. 280 290 - T 21-04-2016 IPR019793 Peroxidases heam-ligand binding site SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Gene3D G3DSA:1.10.420.10 610 731 2.5E-45 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Pfam PF00141 Peroxidase 71 416 3.9E-50 T 21-04-2016 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Pfam PF00141 Peroxidase 423 730 1.2E-41 T 21-04-2016 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 Hamap MF_01961 Catalase-peroxidase [katG]. 4 757 42.7 T 21-04-2016 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PANTHER PTHR30555 230 757 0.0 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 PANTHER PTHR30555 1 206 0.0 T 21-04-2016 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 TIGRFAM TIGR00198 cat_per_HPI: catalase/peroxidase HPI 25 756 0.0 T 21-04-2016 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SPH21_RS12860 22874c0fa1e68da39623e30c577c9830 757 ProSitePatterns PS00436 Peroxidases active site signature. 92 103 - T 21-04-2016 IPR019794 Peroxidase, active site GO:0004601|GO:0055114 SPH21_RS10600 57a39e4897025878dc4d0454f0c0284a 277 PANTHER PTHR14237:SF30 3 267 2.2E-88 T 21-04-2016 SPH21_RS10600 57a39e4897025878dc4d0454f0c0284a 277 SUPERFAMILY SSF141673 4 131 2.22E-37 T 21-04-2016 SPH21_RS10600 57a39e4897025878dc4d0454f0c0284a 277 PANTHER PTHR14237 3 267 2.2E-88 T 21-04-2016 SPH21_RS10600 57a39e4897025878dc4d0454f0c0284a 277 Pfam PF03473 MOSC domain 143 261 1.3E-27 T 21-04-2016 IPR005302 Molybdenum cofactor sulfurase, C-terminal GO:0003824|GO:0030151|GO:0030170 SPH21_RS10600 57a39e4897025878dc4d0454f0c0284a 277 SUPERFAMILY SSF50800 150 264 7.53E-15 T 21-04-2016 IPR011037 Pyruvate kinase-like, insert domain SPH21_RS10600 57a39e4897025878dc4d0454f0c0284a 277 SUPERFAMILY SSF50800 2 44 7.53E-15 T 21-04-2016 IPR011037 Pyruvate kinase-like, insert domain SPH21_RS10600 57a39e4897025878dc4d0454f0c0284a 277 Pfam PF03476 MOSC N-terminal beta barrel domain 1 115 6.7E-28 T 21-04-2016 IPR005303 MOSC, N-terminal beta barrel SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 ProSitePatterns PS01081 TetR-type HTH domain signature. 22 53 - T 21-04-2016 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 56 6.2E-15 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 Gene3D G3DSA:1.10.357.10 3 177 9.7E-21 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 10 23 1.2E-7 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 31 54 1.2E-7 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 PANTHER PTHR30055:SF27 2 92 5.2E-15 T 21-04-2016 SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 SUPERFAMILY SSF46689 3 65 1.7E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS07210 9181cd2645eac7ea22d1d0c4f13e967e 191 PANTHER PTHR30055 2 92 5.2E-15 T 21-04-2016 SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 Gene3D G3DSA:3.40.50.720 4 255 2.8E-70 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 255 8.7E-52 T 21-04-2016 SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 SUPERFAMILY SSF51735 6 255 4.15E-73 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PANTHER PTHR24321 5 256 6.5E-44 T 21-04-2016 SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PANTHER PTHR24321:SF6 5 256 6.5E-44 T 21-04-2016 SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 74 85 7.6E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 7.6E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 7.6E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 7.6E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 7.6E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 218 238 7.6E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 1.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 74 85 1.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24800 f25dd38509791c7ddd56b3cac31a8f39 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 129 137 1.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07300 1284a9ab709a10c0c725e9f80d4aa28f 212 Gene3D G3DSA:3.40.30.10 3 209 4.8E-60 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07300 1284a9ab709a10c0c725e9f80d4aa28f 212 Pfam PF00578 AhpC/TSA family 4 153 3.0E-26 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS07300 1284a9ab709a10c0c725e9f80d4aa28f 212 PANTHER PTHR10681 1 211 3.8E-62 T 21-04-2016 SPH21_RS07300 1284a9ab709a10c0c725e9f80d4aa28f 212 PIRSF PIRSF000239 1 211 3.1E-57 T 21-04-2016 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15 SPH21_RS07300 1284a9ab709a10c0c725e9f80d4aa28f 212 Pfam PF10417 C-terminal domain of 1-Cys peroxiredoxin 176 210 1.5E-7 T 21-04-2016 IPR019479 Peroxiredoxin, C-terminal GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS07300 1284a9ab709a10c0c725e9f80d4aa28f 212 SUPERFAMILY SSF52833 1 209 1.76E-57 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 PANTHER PTHR34069 1 336 3.0E-81 T 21-04-2016 SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 PANTHER PTHR34069:SF2 1 336 3.0E-81 T 21-04-2016 SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 106 183 7.8E-25 T 21-04-2016 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 Gene3D G3DSA:3.40.47.10 1 160 6.0E-48 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 SUPERFAMILY SSF53901 3 170 1.79E-44 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 246 331 9.1E-22 T 21-04-2016 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 Gene3D G3DSA:3.40.47.10 161 334 3.3E-36 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS10245 5d88f3813a949723a3ac1a1d6df079df 336 SUPERFAMILY SSF53901 157 332 2.04E-30 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS07985 b9d5c5ae6fb1dd8549490005dc79e166 380 Gene3D G3DSA:3.40.50.2000 168 349 4.3E-28 T 21-04-2016 SPH21_RS07985 b9d5c5ae6fb1dd8549490005dc79e166 380 SUPERFAMILY SSF53756 7 373 2.23E-82 T 21-04-2016 SPH21_RS07985 b9d5c5ae6fb1dd8549490005dc79e166 380 Pfam PF13439 Glycosyltransferase Family 4 11 180 3.8E-30 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS07985 b9d5c5ae6fb1dd8549490005dc79e166 380 TIGRFAM TIGR03999 thiol_BshA: N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA 1 372 4.5E-172 T 21-04-2016 IPR023881 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA GO:0016757|GO:0071793 SPH21_RS07985 b9d5c5ae6fb1dd8549490005dc79e166 380 PANTHER PTHR12526 1 374 1.3E-154 T 21-04-2016 SPH21_RS07985 b9d5c5ae6fb1dd8549490005dc79e166 380 PANTHER PTHR12526:SF336 1 374 1.3E-154 T 21-04-2016 SPH21_RS07985 b9d5c5ae6fb1dd8549490005dc79e166 380 Pfam PF00534 Glycosyl transferases group 1 187 348 1.5E-36 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 PANTHER PTHR23416:SF23 93 205 8.9E-26 T 21-04-2016 SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 Gene3D G3DSA:3.40.50.20 4 86 2.4E-11 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 TIGRFAM TIGR03570 NeuD_NnaD: sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family 6 205 8.8E-59 T 21-04-2016 IPR020019 Sialic acid O-acyltransferase NeuD-like SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 147 175 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 156 190 1.4E-9 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 120 155 9.8E-8 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 SUPERFAMILY SSF51161 5 205 1.04E-41 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 Gene3D G3DSA:2.160.10.10 92 205 7.5E-30 T 21-04-2016 SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 165 193 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS08975 ed9e5b87d32129e52818066d6ef11073 207 PANTHER PTHR23416 93 205 8.9E-26 T 21-04-2016 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 SMART SM00354 3 73 3.4E-21 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 Gene3D G3DSA:1.10.260.40 4 55 2.0E-18 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 PANTHER PTHR30146 3 339 8.3E-104 T 21-04-2016 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 50 1.6E-10 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 SUPERFAMILY SSF47413 1 62 1.78E-14 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 Pfam PF00532 Periplasmic binding proteins and sugar binding domain of LacI family 63 310 1.2E-33 T 21-04-2016 IPR001761 Periplasmic binding protein/LacI sugar binding domain SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 Gene3D G3DSA:3.40.50.2300 56 176 1.0E-43 T 21-04-2016 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 Gene3D G3DSA:3.40.50.2300 177 313 4.2E-44 T 21-04-2016 SPH21_RS19685 103856ec96b205fbb175c8fd6392ac07 341 SUPERFAMILY SSF53822 63 339 2.75E-69 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS19720 14d800f77cec93df5c3deefdae3f260e 220 PANTHER PTHR11002 13 219 2.0E-89 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS19720 14d800f77cec93df5c3deefdae3f260e 220 Gene3D G3DSA:3.40.1050.10 12 215 4.9E-75 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS19720 14d800f77cec93df5c3deefdae3f260e 220 Pfam PF00484 Carbonic anhydrase 48 200 4.1E-50 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS19720 14d800f77cec93df5c3deefdae3f260e 220 PANTHER PTHR11002:SF20 13 219 2.0E-89 T 21-04-2016 SPH21_RS19720 14d800f77cec93df5c3deefdae3f260e 220 SUPERFAMILY SSF53056 12 214 2.35E-72 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS19720 14d800f77cec93df5c3deefdae3f260e 220 ProSitePatterns PS00704 Prokaryotic-type carbonic anhydrases signature 1. 53 60 - T 21-04-2016 IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site GO:0004089|GO:0008270|GO:0015976 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS19720 14d800f77cec93df5c3deefdae3f260e 220 SMART SM00947 41 204 3.6E-62 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS05245 46bbde7e3644602102518af39ac436b1 112 PANTHER PTHR11586 1 112 7.0E-35 T 21-04-2016 SPH21_RS05245 46bbde7e3644602102518af39ac436b1 112 TIGRFAM TIGR02222 chap_CsaA: export-related chaperone protein CsaA 6 111 2.1E-49 T 21-04-2016 IPR008231 Probable chaperone CsaA SPH21_RS05245 46bbde7e3644602102518af39ac436b1 112 Gene3D G3DSA:2.40.50.140 2 111 1.7E-35 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05245 46bbde7e3644602102518af39ac436b1 112 SUPERFAMILY SSF50249 3 111 1.62E-31 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05245 46bbde7e3644602102518af39ac436b1 112 Pfam PF01588 Putative tRNA binding domain 14 109 2.8E-14 T 21-04-2016 IPR002547 tRNA-binding domain GO:0000049 Reactome: REACT_71 SPH21_RS11370 3fec1f7f6bc26e82285f12e15f799b28 652 Pfam PF14322 Starch-binding associating with outer membrane 106 236 1.8E-21 T 21-04-2016 SPH21_RS11370 3fec1f7f6bc26e82285f12e15f799b28 652 SUPERFAMILY SSF48452 17 534 5.22E-90 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11370 3fec1f7f6bc26e82285f12e15f799b28 652 SUPERFAMILY SSF48452 606 638 5.22E-90 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11370 3fec1f7f6bc26e82285f12e15f799b28 652 Pfam PF07980 SusD family 297 638 5.4E-47 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS11370 3fec1f7f6bc26e82285f12e15f799b28 652 Gene3D G3DSA:1.25.40.10 216 342 2.5E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11370 3fec1f7f6bc26e82285f12e15f799b28 652 Gene3D G3DSA:1.25.40.10 413 507 2.5E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20340 0db898e68a7d72fbfe9696fb47315b93 391 PANTHER PTHR23028 14 384 3.8E-45 T 21-04-2016 SPH21_RS20340 0db898e68a7d72fbfe9696fb47315b93 391 PANTHER PTHR23028:SF53 14 384 3.8E-45 T 21-04-2016 SPH21_RS20340 0db898e68a7d72fbfe9696fb47315b93 391 Pfam PF01757 Acyltransferase family 16 361 2.7E-22 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS03110 593fe8049797402717dab69be849e299 290 PANTHER PTHR11019:SF65 14 290 1.8E-30 T 21-04-2016 SPH21_RS03110 593fe8049797402717dab69be849e299 290 Pfam PF12833 Helix-turn-helix domain 207 284 1.0E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS03110 593fe8049797402717dab69be849e299 290 SUPERFAMILY SSF46689 236 286 1.63E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03110 593fe8049797402717dab69be849e299 290 SMART SM00342 200 283 5.9E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS03110 593fe8049797402717dab69be849e299 290 Gene3D G3DSA:1.10.10.60 237 285 2.9E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03110 593fe8049797402717dab69be849e299 290 Gene3D G3DSA:2.60.120.10 28 76 5.1E-8 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS03110 593fe8049797402717dab69be849e299 290 Gene3D G3DSA:1.10.10.60 177 236 5.5E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03110 593fe8049797402717dab69be849e299 290 PANTHER PTHR11019 14 290 1.8E-30 T 21-04-2016 SPH21_RS03110 593fe8049797402717dab69be849e299 290 SUPERFAMILY SSF46689 184 234 1.71E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03110 593fe8049797402717dab69be849e299 290 SUPERFAMILY SSF51182 16 76 4.69E-8 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS03110 593fe8049797402717dab69be849e299 290 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 237 279 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS15710 1c24e623ffc27d0763d5aa79da476405 271 Pfam PF12864 Protein of unknown function (DUF3822) 11 238 9.8E-44 T 21-04-2016 IPR024213 Protein of unknown function DUF3822 SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 SUPERFAMILY SSF46785 21 148 1.19E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 Gene3D G3DSA:1.10.10.10 22 148 1.1E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 SMART SM00347 36 137 4.5E-13 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 PRINTS PR00598 Bacterial regulatory protein MarR family signature 127 147 1.1E-10 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 PRINTS PR00598 Bacterial regulatory protein MarR family signature 79 94 1.1E-10 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 PRINTS PR00598 Bacterial regulatory protein MarR family signature 98 114 1.1E-10 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 PANTHER PTHR33164 30 147 8.4E-16 T 21-04-2016 SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 PANTHER PTHR33164:SF4 30 147 8.4E-16 T 21-04-2016 SPH21_RS19855 98e6d2c1bf85aa71cd05cd2d9ccce3c0 149 Pfam PF01047 MarR family 43 103 2.1E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 PANTHER PTHR30173 16 178 3.3E-28 T 21-04-2016 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 SUPERFAMILY SSF88946 9 103 7.06E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 Pfam PF08281 Sigma-70, region 4 123 170 2.2E-7 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 Gene3D G3DSA:1.10.1740.10 9 101 2.9E-14 T 21-04-2016 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 178 6.1E-18 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 Gene3D G3DSA:1.10.10.10 119 178 3.7E-9 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 PANTHER PTHR30173:SF20 16 178 3.3E-28 T 21-04-2016 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 Pfam PF04542 Sigma-70 region 2 27 92 5.3E-6 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12375 0b0f5da50b3c42a4359e996ae1cfa941 204 SUPERFAMILY SSF88659 114 178 1.29E-8 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13215 c3e749ac7e68ae84b3f38a3ee2e38825 204 PANTHER PTHR10204 1 194 9.2E-60 T 21-04-2016 SPH21_RS13215 c3e749ac7e68ae84b3f38a3ee2e38825 204 PANTHER PTHR10204:SF36 1 194 9.2E-60 T 21-04-2016 SPH21_RS13215 c3e749ac7e68ae84b3f38a3ee2e38825 204 SUPERFAMILY SSF52218 1 195 1.58E-36 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS13215 c3e749ac7e68ae84b3f38a3ee2e38825 204 Pfam PF02525 Flavodoxin-like fold 2 190 8.3E-31 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS13215 c3e749ac7e68ae84b3f38a3ee2e38825 204 Gene3D G3DSA:3.40.50.360 1 196 3.1E-39 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 PANTHER PTHR36848:SF1 34 157 5.1E-145 T 21-04-2016 SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 PANTHER PTHR36848:SF1 178 915 5.1E-145 T 21-04-2016 SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 Gene3D G3DSA:2.60.120.260 784 949 8.9E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 PANTHER PTHR36848 34 157 5.1E-145 T 21-04-2016 SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 SUPERFAMILY SSF49785 774 948 2.21E-8 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 PANTHER PTHR36848 178 915 5.1E-145 T 21-04-2016 SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 Pfam PF17132 alpha-L-rhamnosidase 214 734 1.6E-59 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS02475 4b35493c2cb0d663c2ad6551edddf91d 956 Pfam PF17132 alpha-L-rhamnosidase 39 157 1.4E-20 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS12150 8967b6e0fedc737663fdccae674c3f48 209 Pfam PF14360 PAP2 superfamily C-terminal 140 201 2.2E-10 T 21-04-2016 IPR025749 Sphingomyelin synthase-like domain SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 SUPERFAMILY SSF56935 988 1081 1.79E-88 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 SUPERFAMILY SSF56935 369 457 1.79E-88 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 SUPERFAMILY SSF56935 897 941 1.79E-88 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 SUPERFAMILY SSF56935 104 274 1.79E-88 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 SUPERFAMILY SSF56935 504 834 1.79E-88 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 PANTHER PTHR11532 22 190 2.3E-221 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 PANTHER PTHR11532 504 1079 2.3E-221 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 PANTHER PTHR11532 218 444 2.3E-221 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 227 257 4.1E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Gene3D G3DSA:2.60.40.1120 25 108 3.1E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 1081 2.4E-205 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Gene3D G3DSA:2.170.130.10 109 251 6.7E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Pfam PF00593 TonB dependent receptor 677 1080 3.6E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 SUPERFAMILY SSF49464 24 105 1.57E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Pfam PF13715 CarboxypepD_reg-like domain 26 107 1.0E-18 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 PANTHER PTHR11532:SF51 22 190 2.3E-221 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 PANTHER PTHR11532:SF51 504 1079 2.3E-221 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 PANTHER PTHR11532:SF51 218 444 2.3E-221 T 21-04-2016 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Gene3D G3DSA:2.40.170.20 907 942 7.2E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Gene3D G3DSA:2.40.170.20 506 850 7.2E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Gene3D G3DSA:2.40.170.20 252 294 7.2E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Gene3D G3DSA:2.40.170.20 376 449 7.2E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Gene3D G3DSA:2.40.170.20 975 1012 7.2E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05420 61263268a12fa521725e90d242f0242b 1081 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 251 5.9E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS15280 caad5ef12968010710e22b301340fbda 329 PANTHER PTHR30213 6 302 2.7E-44 T 21-04-2016 SPH21_RS15280 caad5ef12968010710e22b301340fbda 329 Pfam PF03631 Virulence factor BrkB 49 302 4.1E-59 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS15280 caad5ef12968010710e22b301340fbda 329 PIRSF PIRSF035875 31 316 6.9E-61 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS15280 caad5ef12968010710e22b301340fbda 329 TIGRFAM TIGR00765 yihY_not_rbn: YihY family inner membrane protein 40 301 3.6E-34 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 PRINTS PR00344 Bacterial sensor protein C-terminal signature 524 538 9.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 PRINTS PR00344 Bacterial sensor protein C-terminal signature 583 596 9.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 PRINTS PR00344 Bacterial sensor protein C-terminal signature 542 552 9.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 PRINTS PR00344 Bacterial sensor protein C-terminal signature 559 577 9.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 487 596 9.6E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 SMART SM00387 487 599 2.1E-30 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 Pfam PF00512 His Kinase A (phospho-acceptor) domain 373 441 1.2E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 SUPERFAMILY SSF55874 432 597 6.94E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 Gene3D G3DSA:1.10.287.130 366 437 1.8E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 Gene3D G3DSA:3.30.565.10 442 597 3.2E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 SMART SM00388 373 441 8.4E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 PANTHER PTHR24423 371 596 2.4E-60 T 21-04-2016 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 PANTHER PTHR24423 61 79 2.4E-60 T 21-04-2016 SPH21_RS06560 6055c66fab68b32a840ab5d8cc2f9b77 600 SUPERFAMILY SSF47384 364 442 5.1E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS22740 be205961bda01d0407a88e9d2e50eeeb 103 TIGRFAM TIGR03954 integ_memb_HG: integral membrane protein 12 96 1.4E-24 T 21-04-2016 IPR023845 Domain of unknown function DUF3817, transmembrane SPH21_RS22740 be205961bda01d0407a88e9d2e50eeeb 103 Pfam PF12823 Domain of unknown function (DUF3817) 10 97 3.5E-21 T 21-04-2016 IPR023845 Domain of unknown function DUF3817, transmembrane SPH21_RS22740 be205961bda01d0407a88e9d2e50eeeb 103 PANTHER PTHR40077 2 103 2.9E-14 T 21-04-2016 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 Pfam PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family 166 391 3.9E-58 T 21-04-2016 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|UniPathway: UPA00253 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 Gene3D G3DSA:3.20.140.10 7 377 1.6E-131 T 21-04-2016 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 PANTHER PTHR11098 9 392 9.6E-145 T 21-04-2016 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|UniPathway: UPA00253 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 SUPERFAMILY SSF51690 121 384 1.96E-76 T 21-04-2016 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: REACT_11193|UniPathway: UPA00253 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 PANTHER PTHR11098:SF12 9 392 9.6E-145 T 21-04-2016 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 Hamap MF_00570 Nicotinate phosphoribosyltransferase [pncB]. 4 394 34.512 T 21-04-2016 IPR006406 Nicotinate phosphoribosyltransferase GO:0004516|GO:0019357 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|UniPathway: UPA00253 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 SUPERFAMILY SSF54675 8 136 1.91E-36 T 21-04-2016 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 PIRSF PIRSF000484 1 380 7.9E-62 T 21-04-2016 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|UniPathway: UPA00253 SPH21_RS15255 58ee68c65b8a8e960f97214cb314a31b 394 TIGRFAM TIGR01514 NAPRTase: nicotinate phosphoribosyltransferase 8 388 5.7E-126 T 21-04-2016 IPR006406 Nicotinate phosphoribosyltransferase GO:0004516|GO:0019357 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|UniPathway: UPA00253 SPH21_RS15265 bd3132c294ae9b1aab0acf21657cd818 254 Pfam PF02405 Permease MlaE 37 246 1.5E-71 T 21-04-2016 IPR030802 ABC transporter permease MalE GO:0006810|GO:0043190 SPH21_RS15265 bd3132c294ae9b1aab0acf21657cd818 254 PANTHER PTHR30188 1 240 4.7E-82 T 21-04-2016 IPR030802 ABC transporter permease MalE GO:0006810|GO:0043190 SPH21_RS15265 bd3132c294ae9b1aab0acf21657cd818 254 TIGRFAM TIGR00056 TIGR00056: ABC transport permease subunit 3 249 2.3E-64 T 21-04-2016 IPR003453 ABC transport permease subunit MlaE, Proteobacteria SPH21_RS07480 e94ba7daea92fc2eb54ff075c153591e 258 SUPERFAMILY SSF49464 31 103 1.96E-5 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS24140 2155c0b4eb661a09d59d8fb4a7049138 317 Pfam PF12833 Helix-turn-helix domain 205 282 6.8E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24140 2155c0b4eb661a09d59d8fb4a7049138 317 SUPERFAMILY SSF46689 238 283 3.58E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24140 2155c0b4eb661a09d59d8fb4a7049138 317 SUPERFAMILY SSF51215 16 161 9.42E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24140 2155c0b4eb661a09d59d8fb4a7049138 317 SMART SM00342 198 282 8.2E-13 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24140 2155c0b4eb661a09d59d8fb4a7049138 317 PANTHER PTHR11019 28 290 1.6E-26 T 21-04-2016 SPH21_RS24140 2155c0b4eb661a09d59d8fb4a7049138 317 PANTHER PTHR11019:SF45 28 290 1.6E-26 T 21-04-2016 SPH21_RS24140 2155c0b4eb661a09d59d8fb4a7049138 317 Gene3D G3DSA:1.10.10.60 237 283 7.3E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS15065 24fbb6a68b1ea34afde2fe470a3fa1ee 372 SUPERFAMILY SSF55729 139 341 7.01E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15065 24fbb6a68b1ea34afde2fe470a3fa1ee 372 SUPERFAMILY SSF55729 1 111 7.01E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15065 24fbb6a68b1ea34afde2fe470a3fa1ee 372 PANTHER PTHR41368 1 372 1.4E-105 T 21-04-2016 SPH21_RS15065 24fbb6a68b1ea34afde2fe470a3fa1ee 372 Gene3D G3DSA:3.40.630.30 209 340 1.5E-8 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 Pfam PF01120 Alpha-L-fucosidase 42 334 1.1E-40 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 Gene3D G3DSA:2.60.120.260 355 478 6.4E-15 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 PANTHER PTHR10030:SF25 2 476 4.4E-63 T 21-04-2016 SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 PANTHER PTHR10030 2 476 4.4E-63 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 Gene3D G3DSA:3.20.20.80 42 337 2.1E-69 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 SMART SM00812 36 357 1.5E-15 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 SUPERFAMILY SSF49785 354 477 4.4E-16 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 SUPERFAMILY SSF51445 46 337 5.9E-71 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS10140 89f745d59020abab09fac9da9a97549c 480 Pfam PF00754 F5/8 type C domain 373 459 4.7E-11 T 21-04-2016 IPR000421 Coagulation factor 5/8 C-terminal domain SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 Pfam PF13614 AAA domain 574 728 3.7E-10 T 21-04-2016 IPR025669 AAA domain SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 TIGRFAM TIGR01007 eps_fam: capsular exopolysaccharide family 551 755 4.6E-37 T 21-04-2016 IPR005702 Exopolysaccharide synthesis protein GO:0045226 SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 Pfam PF02706 Chain length determinant protein 18 244 9.9E-11 T 21-04-2016 IPR003856 Lipopolysaccharide biosynthesis GO:0009103|GO:0016020 SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 PANTHER PTHR32309:SF13 181 766 2.1E-117 T 21-04-2016 SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 PANTHER PTHR32309:SF13 18 118 2.1E-117 T 21-04-2016 SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 Pfam PF13807 G-rich domain on putative tyrosine kinase 427 501 1.1E-12 T 21-04-2016 IPR032807 Tyrosine kinase, G-rich domain SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 SUPERFAMILY SSF52540 569 751 2.83E-31 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 PANTHER PTHR32309 181 766 2.1E-117 T 21-04-2016 SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 PANTHER PTHR32309 18 118 2.1E-117 T 21-04-2016 SPH21_RS10005 7979796798a9e56018b0cced82cb5f10 776 Gene3D G3DSA:3.40.50.300 569 748 3.3E-29 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23975 f7bd33754c35d462fb724ad85b275fcf 603 SUPERFAMILY SSF48452 270 603 4.55E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23975 f7bd33754c35d462fb724ad85b275fcf 603 SUPERFAMILY SSF48452 20 242 4.55E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23975 f7bd33754c35d462fb724ad85b275fcf 603 Pfam PF07980 SusD family 310 603 5.8E-57 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23975 f7bd33754c35d462fb724ad85b275fcf 603 Gene3D G3DSA:1.25.40.10 430 523 7.5E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23975 f7bd33754c35d462fb724ad85b275fcf 603 Gene3D G3DSA:1.25.40.10 216 356 7.5E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23975 f7bd33754c35d462fb724ad85b275fcf 603 Pfam PF14322 Starch-binding associating with outer membrane 23 201 6.2E-10 T 21-04-2016 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 PANTHER PTHR30295:SF6 1 163 4.3E-55 T 21-04-2016 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 PIRSF PIRSF005900 3 163 3.6E-48 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 Gene3D G3DSA:1.20.1260.10 5 163 9.1E-60 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 PANTHER PTHR30295 1 163 4.3E-55 T 21-04-2016 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 SUPERFAMILY SSF47240 9 162 5.17E-43 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 43 59 5.5E-12 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 140 158 5.5E-12 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 67 83 5.5E-12 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 ProSitePatterns PS00818 Dps protein family signature 1. 43 59 - T 21-04-2016 IPR023188 DNA-binding protein Dps, conserved site GO:0016722|GO:0055114 SPH21_RS03845 610da4416f641555edc51098d6ba0f05 163 Pfam PF00210 Ferritin-like domain 23 162 1.3E-31 T 21-04-2016 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 PIRSF PIRSF000349 1 203 1.3E-81 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 PRINTS PR01703 Manganese superoxide dismutase signature 27 40 2.2E-26 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 PRINTS PR01703 Manganese superoxide dismutase signature 121 129 2.2E-26 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 PRINTS PR01703 Manganese superoxide dismutase signature 68 81 2.2E-26 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 PRINTS PR01703 Manganese superoxide dismutase signature 162 174 2.2E-26 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 PRINTS PR01703 Manganese superoxide dismutase signature 6 17 2.2E-26 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 SUPERFAMILY SSF54719 89 202 8.64E-42 T 21-04-2016 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 SUPERFAMILY SSF46609 1 86 6.68E-37 T 21-04-2016 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 PANTHER PTHR11404 1 203 6.1E-106 T 21-04-2016 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 ProSitePatterns PS00088 Manganese and iron superoxide dismutases signature. 164 171 - T 21-04-2016 IPR019833 Manganese/iron superoxide dismutase, binding site GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 Pfam PF02777 Iron/manganese superoxide dismutases, C-terminal domain 92 197 2.4E-39 T 21-04-2016 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 Gene3D G3DSA:1.10.287.990 20 85 7.0E-30 T 21-04-2016 SPH21_RS05235 70940b6418a88a5f01bf08018ccd71ad 203 Pfam PF00081 Iron/manganese superoxide dismutases, alpha-hairpin domain 3 85 3.7E-34 T 21-04-2016 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854 SPH21_RS00880 c60505c58d02d7000068ca8ce494ba47 266 Gene3D G3DSA:3.40.50.1820 16 261 4.1E-66 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00880 c60505c58d02d7000068ca8ce494ba47 266 PANTHER PTHR40841 22 191 1.3E-27 T 21-04-2016 SPH21_RS00880 c60505c58d02d7000068ca8ce494ba47 266 SUPERFAMILY SSF53474 12 261 3.57E-49 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00880 c60505c58d02d7000068ca8ce494ba47 266 Pfam PF00756 Putative esterase 22 191 4.9E-27 T 21-04-2016 IPR000801 Putative esterase SPH21_RS00880 c60505c58d02d7000068ca8ce494ba47 266 PANTHER PTHR40841:SF2 22 191 1.3E-27 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 SUPERFAMILY SSF49464 131 211 7.32E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 PANTHER PTHR11532 555 1094 4.1E-264 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 PANTHER PTHR11532 121 454 4.1E-264 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Pfam PF07715 TonB-dependent Receptor Plug Domain 223 328 4.0E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Pfam PF07660 Secretin and TonB N terminus short domain 64 115 9.8E-10 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 304 334 5.5E-20 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Pfam PF00593 TonB dependent receptor 698 1094 3.8E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Gene3D G3DSA:2.170.130.10 215 329 3.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Gene3D G3DSA:2.60.40.1120 131 214 6.5E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 131 1096 2.0E-278 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Gene3D G3DSA:2.40.170.20 901 975 9.1E-67 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Gene3D G3DSA:2.40.170.20 511 861 9.1E-67 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Gene3D G3DSA:2.40.170.20 1015 1096 9.1E-67 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Gene3D G3DSA:2.40.170.20 330 351 9.1E-67 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Gene3D G3DSA:2.40.170.20 409 473 9.1E-67 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 PANTHER PTHR11532:SF57 555 1094 4.1E-264 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 PANTHER PTHR11532:SF57 121 454 4.1E-264 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 SMART SM00965 63 115 4.1E-6 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 Pfam PF13715 CarboxypepD_reg-like domain 132 213 1.1E-16 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 SUPERFAMILY SSF56935 526 863 2.23E-105 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 SUPERFAMILY SSF56935 1005 1096 2.23E-105 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 SUPERFAMILY SSF56935 923 967 2.23E-105 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 SUPERFAMILY SSF56935 209 352 2.23E-105 T 21-04-2016 SPH21_RS14095 65679bf9c07c6ed88f967d5d8dae6a44 1096 SUPERFAMILY SSF56935 400 488 2.23E-105 T 21-04-2016 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 SMART SM00421 140 188 0.0021 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 Gene3D G3DSA:1.10.1740.10 2 97 8.0E-18 T 21-04-2016 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 SUPERFAMILY SSF88659 113 180 3.05E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 Pfam PF04542 Sigma-70 region 2 27 92 2.9E-7 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 Pfam PF08281 Sigma-70, region 4 128 176 2.6E-10 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 24 180 2.9E-20 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 23 179 1.7E-41 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 SUPERFAMILY SSF88946 1 97 8.24E-19 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 PANTHER PTHR30173:SF20 1 193 1.6E-43 T 21-04-2016 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 PANTHER PTHR30173 1 193 1.6E-43 T 21-04-2016 SPH21_RS14705 b66195526e999a01971e0a13cf549035 194 Gene3D G3DSA:1.10.10.10 120 181 3.6E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Gene3D G3DSA:2.20.28.20 145 176 6.9E-19 T 21-04-2016 IPR029038 Methionyl-tRNA synthetase, Zn-domain KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Pfam PF01588 Putative tRNA binding domain 593 685 2.9E-22 T 21-04-2016 IPR002547 tRNA-binding domain GO:0000049 Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 SUPERFAMILY SSF50249 583 687 2.69E-26 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PRINTS PR01041 Methionyl-tRNA synthetase signature 42 56 2.1E-27 T 21-04-2016 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PRINTS PR01041 Methionyl-tRNA synthetase signature 393 404 2.1E-27 T 21-04-2016 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PRINTS PR01041 Methionyl-tRNA synthetase signature 90 101 2.1E-27 T 21-04-2016 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PRINTS PR01041 Methionyl-tRNA synthetase signature 9 22 2.1E-27 T 21-04-2016 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PRINTS PR01041 Methionyl-tRNA synthetase signature 255 266 2.1E-27 T 21-04-2016 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PRINTS PR01041 Methionyl-tRNA synthetase signature 298 313 2.1E-27 T 21-04-2016 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 TIGRFAM TIGR00398 metG: methionine--tRNA ligase 8 549 1.5E-169 T 21-04-2016 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Pfam PF08264 Anticodon-binding domain of tRNA 427 522 2.1E-11 T 21-04-2016 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 TIGRFAM TIGR00399 metG_C_term: methionine--tRNA ligase, beta subunit 562 687 4.6E-36 T 21-04-2016 IPR004495 Methionyl-tRNA synthetase, beta subunit, C-terminal GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 SUPERFAMILY SSF47323 398 599 1.64E-43 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Gene3D G3DSA:1.10.730.10 389 549 7.0E-47 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 14 25 - T 21-04-2016 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 SUPERFAMILY SSF57770 142 176 7.72E-12 T 21-04-2016 IPR029038 Methionyl-tRNA synthetase, Zn-domain KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Gene3D G3DSA:2.40.50.140 580 687 1.2E-36 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Gene3D G3DSA:3.40.50.620 183 388 2.1E-83 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Gene3D G3DSA:3.40.50.620 5 144 2.1E-83 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Pfam PF09334 tRNA synthetases class I (M) 8 406 6.8E-155 T 21-04-2016 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PANTHER PTHR11946:SF72 1 643 0.0 T 21-04-2016 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 PANTHER PTHR11946 1 643 0.0 T 21-04-2016 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 Hamap MF_00098 Methionine--tRNA ligase [metG]. 5 560 39.768 T 21-04-2016 IPR023458 Methionine-tRNA ligase, type 1 GO:0004825 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 SUPERFAMILY SSF52374 5 141 3.26E-92 T 21-04-2016 SPH21_RS07025 ea43db8f802153da90eef8eff1f84246 688 SUPERFAMILY SSF52374 176 393 3.26E-92 T 21-04-2016 SPH21_RS19215 55a90356f319176754bac88253c260be 65 PIRSF PIRSF002599 1 65 1.0E-18 T 21-04-2016 IPR012156 Cold shock, CspA GO:0003676 SPH21_RS19215 55a90356f319176754bac88253c260be 65 SUPERFAMILY SSF50249 1 65 7.71E-21 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19215 55a90356f319176754bac88253c260be 65 PANTHER PTHR11544 1 65 1.1E-17 T 21-04-2016 SPH21_RS19215 55a90356f319176754bac88253c260be 65 Pfam PF00313 'Cold-shock' DNA-binding domain 3 64 3.5E-23 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS19215 55a90356f319176754bac88253c260be 65 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 33 - T 21-04-2016 IPR019844 Cold-shock conserved site SPH21_RS19215 55a90356f319176754bac88253c260be 65 PRINTS PR00050 Cold shock protein signature 24 33 6.1E-14 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS19215 55a90356f319176754bac88253c260be 65 PRINTS PR00050 Cold shock protein signature 38 56 6.1E-14 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS19215 55a90356f319176754bac88253c260be 65 PRINTS PR00050 Cold shock protein signature 4 19 6.1E-14 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS19215 55a90356f319176754bac88253c260be 65 SMART SM00357 3 65 1.1E-22 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS19215 55a90356f319176754bac88253c260be 65 Gene3D G3DSA:2.40.50.140 1 64 7.7E-26 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PIRSF PIRSF004557 1 430 2.4E-118 T 21-04-2016 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: REACT_15380 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 ProSitePatterns PS00756 Protein secY signature 2. 164 181 - T 21-04-2016 IPR030659 SecY conserved site SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 SUPERFAMILY SSF103491 4 414 1.44E-116 T 21-04-2016 IPR023201 SecY subunit domain SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 392 410 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 357 375 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 302 324 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 145 170 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 111 134 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 21 39 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 263 282 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 70 90 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PRINTS PR00303 Preprotein translocase SecY subunit signature 171 194 6.0E-90 T 21-04-2016 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PANTHER PTHR10906 4 437 5.3E-181 T 21-04-2016 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: REACT_15380 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 Pfam PF00344 SecY translocase 72 406 5.5E-112 T 21-04-2016 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: REACT_15380 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 TIGRFAM TIGR00967 3a0501s007: preprotein translocase, SecY subunit 18 417 8.9E-117 T 21-04-2016 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: REACT_15380 SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 Hamap MF_01465 Protein translocase subunit SecY [secY]. 8 423 28.426 T 21-04-2016 IPR026593 Protein translocase subunit SecY SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 Gene3D G3DSA:1.10.3370.10 6 427 4.3E-146 T 21-04-2016 IPR023201 SecY subunit domain SPH21_RS08595 a87a790bec7c6cb3c238722ee9c73543 443 PANTHER PTHR10906:SF2 4 437 5.3E-181 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 Gene3D G3DSA:3.30.360.10 197 349 4.4E-18 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 Gene3D G3DSA:3.30.360.10 407 461 4.4E-18 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 SUPERFAMILY SSF51735 43 207 4.32E-40 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 PANTHER PTHR22604:SF122 3 210 1.3E-60 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 PANTHER PTHR22604:SF122 349 470 1.3E-60 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 PANTHER PTHR22604:SF122 228 311 1.3E-60 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 Gene3D G3DSA:3.40.50.720 50 196 9.6E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 SUPERFAMILY SSF55347 184 208 8.28E-16 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 SUPERFAMILY SSF55347 242 364 8.28E-16 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 PANTHER PTHR22604 3 210 1.3E-60 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 PANTHER PTHR22604 349 470 1.3E-60 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 PANTHER PTHR22604 228 311 1.3E-60 T 21-04-2016 SPH21_RS02885 4008f56d76120b1cf731705046fbf05f 471 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 56 175 1.2E-15 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS25675 9560cf3948c55e6f5b3ce2ac12c8b996 194 PANTHER PTHR31223:SF0 1 194 2.8E-82 T 21-04-2016 SPH21_RS25675 9560cf3948c55e6f5b3ce2ac12c8b996 194 PANTHER PTHR31223 1 194 2.8E-82 T 21-04-2016 SPH21_RS25675 9560cf3948c55e6f5b3ce2ac12c8b996 194 Pfam PF03641 Possible lysine decarboxylase 46 176 3.2E-43 T 21-04-2016 IPR031100 LOG family SPH21_RS25675 9560cf3948c55e6f5b3ce2ac12c8b996 194 SUPERFAMILY SSF102405 2 179 5.49E-62 T 21-04-2016 SPH21_RS25675 9560cf3948c55e6f5b3ce2ac12c8b996 194 TIGRFAM TIGR00730 TIGR00730: TIGR00730 family protein 2 179 2.1E-60 T 21-04-2016 IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG SPH21_RS25675 9560cf3948c55e6f5b3ce2ac12c8b996 194 Gene3D G3DSA:3.40.50.450 2 176 3.5E-68 T 21-04-2016 SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 PRINTS PR00344 Bacterial sensor protein C-terminal signature 331 345 2.1E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 PRINTS PR00344 Bacterial sensor protein C-terminal signature 386 399 2.1E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 PRINTS PR00344 Bacterial sensor protein C-terminal signature 349 359 2.1E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 PRINTS PR00344 Bacterial sensor protein C-terminal signature 360 378 2.1E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 SMART SM00387 292 402 3.1E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 Gene3D G3DSA:3.30.565.10 259 398 1.5E-26 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 300 399 7.9E-17 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 SUPERFAMILY SSF55874 253 399 5.9E-27 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07075 ba9db6e9030eff0549af5a33d8bdc2a7 409 PANTHER PTHR24423 188 398 4.9E-28 T 21-04-2016 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 SUPERFAMILY SSF53067 283 546 6.76E-50 T 21-04-2016 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 292 503 2.2E-38 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 Gene3D G3DSA:3.30.420.40 1 281 3.1E-41 T 21-04-2016 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 PANTHER PTHR10196 1 545 1.8E-199 T 21-04-2016 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 SUPERFAMILY SSF53067 5 281 4.96E-29 T 21-04-2016 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 TIGRFAM TIGR01234 L-ribulokinase: ribulokinase 5 552 7.7E-181 T 21-04-2016 IPR005929 Ribulokinase GO:0005524|GO:0008741|GO:0019569 KEGG: 00040+2.7.1.16|UniPathway: UPA00145 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 Gene3D G3DSA:3.30.420.40 286 546 1.0E-52 T 21-04-2016 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 5 281 8.1E-15 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 PANTHER PTHR10196:SF62 1 545 1.8E-199 T 21-04-2016 SPH21_RS03035 ba2d198a956f39c22d9ba2cfb98d6e5e 553 PIRSF PIRSF000538 3 551 1.3E-48 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 Gene3D G3DSA:3.40.810.20 229 491 4.3E-72 T 21-04-2016 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 SUPERFAMILY SSF100950 229 496 1.26E-75 T 21-04-2016 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 PANTHER PTHR21432 1 496 1.5E-235 T 21-04-2016 IPR003702 Acetyl-CoA hydrolase/transferase GO:0003824|GO:0006084 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 SUPERFAMILY SSF100950 4 222 1.94E-59 T 21-04-2016 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 Pfam PF02550 Acetyl-CoA hydrolase/transferase N-terminal domain 10 215 3.0E-27 T 21-04-2016 IPR003702 Acetyl-CoA hydrolase/transferase GO:0003824|GO:0006084 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 Gene3D G3DSA:3.40.1080.10 13 221 6.7E-36 T 21-04-2016 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 Pfam PF13336 Acetyl-CoA hydrolase/transferase C-terminal domain 319 463 9.0E-39 T 21-04-2016 IPR026888 Acetyl-CoA hydrolase/transferase C-terminal domain SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 PANTHER PTHR21432:SF10 1 496 1.5E-235 T 21-04-2016 SPH21_RS08475 2293074e3b33504b61300ac6b6448a15 498 TIGRFAM TIGR03458 YgfH_subfam: succinate CoA transferase 18 495 7.9E-209 T 21-04-2016 IPR017821 Succinate CoA transferase GO:0006084|GO:0016740 SPH21_RS16605 90adaa5b5b8e5aa3ed515afec8e6559b 211 PANTHER PTHR41913 47 204 1.5E-26 T 21-04-2016 SPH21_RS16605 90adaa5b5b8e5aa3ed515afec8e6559b 211 PANTHER PTHR41913:SF1 47 204 1.5E-26 T 21-04-2016 SPH21_RS16605 90adaa5b5b8e5aa3ed515afec8e6559b 211 Pfam PF07920 Protein of unknown function (DUF1684) 54 198 5.6E-43 T 21-04-2016 IPR012467 Protein of unknown function DUF1684 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 SUPERFAMILY SSF81271 2 62 4.36E-17 T 21-04-2016 IPR012676 TGS-like KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 169 218 9.9E-16 T 21-04-2016 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 SUPERFAMILY SSF55186 63 240 1.57E-60 T 21-04-2016 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain GO:0000166 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 PANTHER PTHR11451 1 639 8.7E-303 T 21-04-2016 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 PRINTS PR01047 Threonyl-tRNA synthetase signature 332 360 6.7E-53 T 21-04-2016 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 PRINTS PR01047 Threonyl-tRNA synthetase signature 365 388 6.7E-53 T 21-04-2016 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 PRINTS PR01047 Threonyl-tRNA synthetase signature 541 553 6.7E-53 T 21-04-2016 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 PRINTS PR01047 Threonyl-tRNA synthetase signature 514 527 6.7E-53 T 21-04-2016 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 PRINTS PR01047 Threonyl-tRNA synthetase signature 471 499 6.7E-53 T 21-04-2016 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 SUPERFAMILY SSF55681 242 533 2.99E-95 T 21-04-2016 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Gene3D G3DSA:3.30.54.20 132 186 1.3E-20 T 21-04-2016 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Pfam PF03129 Anticodon binding domain 548 637 6.7E-22 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 PANTHER PTHR11451:SF5 1 639 8.7E-303 T 21-04-2016 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Gene3D G3DSA:3.30.930.10 241 536 6.1E-113 T 21-04-2016 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Gene3D G3DSA:3.40.50.800 539 639 1.4E-32 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 326 535 1.4E-42 T 21-04-2016 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Gene3D G3DSA:3.10.20.30 1 64 2.4E-25 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Hamap MF_00184 Threonine--tRNA ligase [thrS]. 66 641 34.41 T 21-04-2016 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 SUPERFAMILY SSF52954 537 639 1.51E-28 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Pfam PF02824 TGS domain 2 61 9.5E-13 T 21-04-2016 IPR004095 TGS KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 TIGRFAM TIGR00418 thrS: threonine--tRNA ligase 72 638 1.5E-220 T 21-04-2016 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 SMART SM00863 169 218 8.1E-24 T 21-04-2016 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Gene3D G3DSA:3.30.980.10 187 223 6.4E-37 T 21-04-2016 SPH21_RS14750 5bdc7931c8a949d66b509e5875ed7c53 641 Gene3D G3DSA:3.30.980.10 66 130 6.4E-37 T 21-04-2016 SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 PANTHER PTHR26402 4 108 9.5E-23 T 21-04-2016 SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 SUPERFAMILY SSF52172 3 119 4.98E-21 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 Gene3D G3DSA:3.40.50.2300 3 115 3.9E-22 T 21-04-2016 SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 SMART SM00448 4 111 3.0E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 Gene3D G3DSA:2.40.50.40 126 195 1.0E-4 T 21-04-2016 SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 Pfam PF00072 Response regulator receiver domain 7 111 1.0E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 SMART SM00850 133 233 1.6E-5 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS19150 0c46b71318b6b16fe10476c07bfd054c 234 PANTHER PTHR26402:SF472 4 108 9.5E-23 T 21-04-2016 SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 Pfam PF04616 Glycosyl hydrolases family 43 345 633 2.1E-64 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 Pfam PF04616 Glycosyl hydrolases family 43 88 280 1.9E-9 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 Gene3D G3DSA:2.115.10.20 87 287 3.6E-26 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 PANTHER PTHR22925:SF42 344 635 1.3E-68 T 21-04-2016 SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 SUPERFAMILY SSF75005 87 321 4.19E-26 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 Gene3D G3DSA:2.115.10.20 345 644 2.7E-71 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 PANTHER PTHR22925 344 635 1.3E-68 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS03900 9a6fad671229498db3901c65b1d6a07e 649 SUPERFAMILY SSF75005 344 635 3.57E-64 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Pfam PF14905 Outer membrane protein beta-barrel family 696 788 2.5E-7 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Gene3D G3DSA:2.60.40.1120 35 117 9.0E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 PANTHER PTHR11532 585 1035 1.1E-173 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 PANTHER PTHR11532 231 525 1.1E-173 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 PANTHER PTHR11532 1 201 1.1E-173 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 240 270 1.6E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Gene3D G3DSA:2.170.130.10 118 263 3.9E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 PANTHER PTHR11532:SF51 585 1035 1.1E-173 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 PANTHER PTHR11532:SF51 231 525 1.1E-173 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 PANTHER PTHR11532:SF51 1 201 1.1E-173 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Pfam PF13715 CarboxypepD_reg-like domain 35 116 5.6E-19 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Pfam PF07715 TonB-dependent Receptor Plug Domain 126 264 5.0E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 SUPERFAMILY SSF49464 33 114 8.11E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 35 1037 2.6E-185 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 SUPERFAMILY SSF56935 329 417 8.79E-78 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 SUPERFAMILY SSF56935 459 790 8.79E-78 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 SUPERFAMILY SSF56935 845 888 8.79E-78 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 SUPERFAMILY SSF56935 113 288 8.79E-78 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 SUPERFAMILY SSF56935 937 983 8.79E-78 T 21-04-2016 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Gene3D G3DSA:2.40.170.20 443 790 9.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Gene3D G3DSA:2.40.170.20 338 402 9.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Gene3D G3DSA:2.40.170.20 926 1037 9.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Gene3D G3DSA:2.40.170.20 830 878 9.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01850 d544731a9324210b78084e94584afdd5 1037 Gene3D G3DSA:2.40.170.20 264 306 9.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 76 187 1.7E-13 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 SUPERFAMILY SSF56784 5 215 1.29E-50 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 PANTHER PTHR18901 1 216 1.4E-57 T 21-04-2016 SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 Pfam PF13419 Haloacid dehalogenase-like hydrolase 9 189 7.0E-37 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 6 17 6.6E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 134 150 6.6E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 152 172 6.6E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 103 116 6.6E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 Gene3D G3DSA:3.40.50.1000 94 215 2.5E-41 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS09695 2d421d87bca07f058abfe29d1801e524 220 Gene3D G3DSA:3.40.50.1000 2 20 2.5E-41 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 SUPERFAMILY SSF47413 4 62 2.16E-14 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 51 1.1E-13 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 SMART SM00354 4 74 9.5E-23 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 Gene3D G3DSA:3.40.50.2300 177 315 2.0E-38 T 21-04-2016 SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 Gene3D G3DSA:1.10.260.40 5 56 6.4E-20 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 Gene3D G3DSA:3.40.50.2300 57 176 1.3E-43 T 21-04-2016 SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 Pfam PF00532 Periplasmic binding proteins and sugar binding domain of LacI family 63 328 1.2E-30 T 21-04-2016 IPR001761 Periplasmic binding protein/LacI sugar binding domain SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 PANTHER PTHR30146 5 336 1.3E-103 T 21-04-2016 SPH21_RS01825 a4039291e2255626c6b66e846059c154 337 SUPERFAMILY SSF53822 65 335 4.12E-71 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 Pfam PF01055 Glycosyl hydrolases family 31 381 837 2.3E-130 T 21-04-2016 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 SMART SM00758 230 371 0.0075 T 21-04-2016 IPR011658 PA14 domain SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 Pfam PF17137 Domain of unknown function (DUF5110) 855 920 3.9E-18 T 21-04-2016 IPR033403 Domain of unknown function DUF5110 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 SUPERFAMILY SSF74650 27 211 5.65E-21 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 SUPERFAMILY SSF51011 753 832 3.6E-21 T 21-04-2016 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 SUPERFAMILY SSF51445 391 749 1.99E-64 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 PANTHER PTHR22762:SF86 362 947 4.2E-254 T 21-04-2016 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 PANTHER PTHR22762:SF86 47 214 4.2E-254 T 21-04-2016 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 SUPERFAMILY SSF56988 235 359 6.28E-7 T 21-04-2016 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 Pfam PF16338 Domain of unknown function (DUF4968) 29 126 3.0E-8 T 21-04-2016 IPR032513 Alpha-glucosidase, domain of unknown function DUF4968 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 Pfam PF07691 PA14 domain 231 359 2.4E-6 T 21-04-2016 IPR011658 PA14 domain SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 PANTHER PTHR22762 362 947 4.2E-254 T 21-04-2016 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 PANTHER PTHR22762 47 214 4.2E-254 T 21-04-2016 SPH21_RS19485 aed9b7a63c28c20784067363914fb094 952 Gene3D G3DSA:3.90.182.10 225 359 4.0E-13 T 21-04-2016 IPR011658 PA14 domain SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 Gene3D G3DSA:3.40.50.2000 9 182 6.5E-11 T 21-04-2016 SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 SUPERFAMILY SSF53756 9 426 8.03E-53 T 21-04-2016 SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 Gene3D G3DSA:3.40.50.2000 262 412 1.0E-14 T 21-04-2016 SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 PANTHER PTHR11926:SF240 5 180 1.1E-34 T 21-04-2016 SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 PANTHER PTHR11926:SF240 213 409 1.1E-34 T 21-04-2016 SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 213 408 7.1E-8 T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 PANTHER PTHR11926 5 180 1.1E-34 T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS23935 4e4589fd566a7a45d3e286f8d1ee5e63 432 PANTHER PTHR11926 213 409 1.1E-34 T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 148 5.9E-27 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 Gene3D G3DSA:3.90.180.10 2 194 8.6E-52 T 21-04-2016 IPR011032 GroES-like SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 PANTHER PTHR11695:SF281 290 391 1.4E-139 T 21-04-2016 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 Pfam PF13823 Alcohol dehydrogenase GroES-associated 3 24 7.2E-8 T 21-04-2016 IPR027399 Alcohol dehydrogenase GroES-associated SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 61 75 - T 21-04-2016 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 Gene3D G3DSA:3.40.50.720 195 334 7.0E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 SUPERFAMILY SSF51735 165 353 1.12E-60 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 PANTHER PTHR11695 128 265 1.4E-139 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 PANTHER PTHR11695 14 108 1.4E-139 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 PANTHER PTHR11695 290 391 1.4E-139 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 Pfam PF00107 Zinc-binding dehydrogenase 198 268 4.3E-13 T 21-04-2016 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 SMART SM00829 10 355 0.0042 T 21-04-2016 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 PANTHER PTHR11695:SF281 128 265 1.4E-139 T 21-04-2016 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 PANTHER PTHR11695:SF281 14 108 1.4E-139 T 21-04-2016 SPH21_RS18900 b1d211e337897312a92fc0d186a4546b 398 SUPERFAMILY SSF50129 3 188 1.52E-54 T 21-04-2016 IPR011032 GroES-like SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 PANTHER PTHR11102 543 773 1.1E-35 T 21-04-2016 SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 PANTHER PTHR11102 5 33 1.1E-35 T 21-04-2016 SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 SUPERFAMILY SSF81901 536 773 3.14E-42 T 21-04-2016 SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF14903 WG containing repeat 308 342 0.14 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF14903 WG containing repeat 272 308 3.1E-7 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF14903 WG containing repeat 235 272 5.7E-7 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Gene3D G3DSA:1.25.40.10 155 177 1.2E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Gene3D G3DSA:1.25.40.10 674 772 2.7E-15 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Gene3D G3DSA:1.25.40.10 539 673 1.2E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 SMART SM00671 703 738 2.7E-4 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 SMART SM00671 565 599 2.9 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 SMART SM00671 600 635 3.4E-8 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 SMART SM00671 636 671 2.9E-5 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF08238 Sel1 repeat 600 634 3.8E-7 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF08238 Sel1 repeat 537 564 17.0 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF08238 Sel1 repeat 705 738 0.035 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF08238 Sel1 repeat 637 670 7.3E-4 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF08238 Sel1 repeat 754 772 0.65 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS12670 46bd4bb8ff31b8d783c7c664daec0fd4 776 Pfam PF08238 Sel1 repeat 567 599 0.16 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 Pfam PF08281 Sigma-70, region 4 124 176 1.1E-11 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 Gene3D G3DSA:1.10.1740.10 7 102 9.8E-16 T 21-04-2016 SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 Gene3D G3DSA:1.10.10.10 117 182 2.6E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 SUPERFAMILY SSF88659 112 182 3.71E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 PANTHER PTHR30173 8 184 1.4E-25 T 21-04-2016 SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 180 3.4E-20 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 Pfam PF04542 Sigma-70 region 2 27 95 4.6E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00465 72f1d3631c5525b15f8d05c3a660db27 189 SUPERFAMILY SSF88946 5 106 2.04E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14300 81a7b2b232f10c107ad1177da32b616b 374 Pfam PF01168 Alanine racemase, N-terminal domain 29 248 1.9E-21 T 21-04-2016 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS14300 81a7b2b232f10c107ad1177da32b616b 374 PANTHER PTHR28004:SF1 3 372 2.7E-69 T 21-04-2016 SPH21_RS14300 81a7b2b232f10c107ad1177da32b616b 374 PANTHER PTHR28004 3 372 2.7E-69 T 21-04-2016 SPH21_RS14300 81a7b2b232f10c107ad1177da32b616b 374 SUPERFAMILY SSF51419 27 256 7.63E-31 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS14300 81a7b2b232f10c107ad1177da32b616b 374 SMART SM01119 265 355 3.1E-20 T 21-04-2016 IPR026956 D-serine dehydratase-like domain SPH21_RS14300 81a7b2b232f10c107ad1177da32b616b 374 Pfam PF14031 Putative serine dehydratase domain 265 353 5.8E-15 T 21-04-2016 IPR026956 D-serine dehydratase-like domain SPH21_RS14300 81a7b2b232f10c107ad1177da32b616b 374 Gene3D G3DSA:3.20.20.10 29 206 4.3E-17 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS04170 3798521c06e9a27117dcb4be270b9815 389 Pfam PF13173 AAA domain 32 153 9.0E-29 T 21-04-2016 SPH21_RS04170 3798521c06e9a27117dcb4be270b9815 389 PANTHER PTHR33295:SF1 26 342 8.4E-66 T 21-04-2016 SPH21_RS04170 3798521c06e9a27117dcb4be270b9815 389 Gene3D G3DSA:3.40.50.300 32 125 6.0E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04170 3798521c06e9a27117dcb4be270b9815 389 PANTHER PTHR33295 26 342 8.4E-66 T 21-04-2016 SPH21_RS04170 3798521c06e9a27117dcb4be270b9815 389 SUPERFAMILY SSF52540 31 159 4.69E-19 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04170 3798521c06e9a27117dcb4be270b9815 389 SMART SM00382 30 157 7.5E-5 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 ProSitePatterns PS00646 Ribosomal protein S13 signature. 88 101 - T 21-04-2016 IPR018269 Ribosomal protein S13, conserved site GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 Gene3D G3DSA:1.10.8.50 1 71 1.2E-28 T 21-04-2016 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 PANTHER PTHR10871 1 123 3.5E-66 T 21-04-2016 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 SUPERFAMILY SSF46946 2 122 7.21E-44 T 21-04-2016 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 PIRSF PIRSF002134 1 125 6.7E-40 T 21-04-2016 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 Pfam PF00416 Ribosomal protein S13/S18 3 109 5.4E-31 T 21-04-2016 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 Hamap MF_01315 30S ribosomal protein S13 [rpsM]. 1 120 27.391 T 21-04-2016 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 TIGRFAM TIGR03631 uS13_bact: ribosomal protein uS13 3 115 9.6E-53 T 21-04-2016 IPR019980 Ribosomal protein S13, bacterial-type GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08610 a3aab289256e22e3fd4247ed628acf35 125 Gene3D G3DSA:4.10.910.10 73 124 7.2E-28 T 21-04-2016 IPR027437 30s ribosomal protein S13, C-terminal SPH21_RS14655 af73aadf8ff789e52c15f4931b0b4655 300 SUPERFAMILY SSF51658 41 289 1.02E-41 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14655 af73aadf8ff789e52c15f4931b0b4655 300 Gene3D G3DSA:3.20.20.150 44 286 2.1E-37 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14655 af73aadf8ff789e52c15f4931b0b4655 300 PANTHER PTHR12110 65 299 3.2E-19 T 21-04-2016 SPH21_RS14655 af73aadf8ff789e52c15f4931b0b4655 300 Pfam PF01261 Xylose isomerase-like TIM barrel 65 223 3.1E-14 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 PANTHER PTHR31339 27 413 5.3E-83 T 21-04-2016 SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 Pfam PF00295 Glycosyl hydrolases family 28 120 415 9.8E-29 T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 PANTHER PTHR31339:SF0 27 413 5.3E-83 T 21-04-2016 SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 SUPERFAMILY SSF51126 49 416 2.26E-72 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 SMART SM00710 250 271 1.1 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 SMART SM00710 286 306 1500.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 SMART SM00710 403 425 2600.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 SMART SM00710 217 249 980.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 SMART SM00710 311 347 2600.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02415 4de43e3d1b3b42bbf170bcc0b7f701d5 443 Gene3D G3DSA:2.160.20.10 48 418 6.2E-85 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS19690 fc4f6f8795168801ba527d1737c4610a 431 PANTHER PTHR30203 36 428 9.6E-46 T 21-04-2016 SPH21_RS19690 fc4f6f8795168801ba527d1737c4610a 431 Pfam PF02321 Outer membrane efflux protein 35 222 6.5E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS19690 fc4f6f8795168801ba527d1737c4610a 431 Pfam PF02321 Outer membrane efflux protein 252 380 2.4E-15 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS19690 fc4f6f8795168801ba527d1737c4610a 431 Gene3D G3DSA:1.20.1600.10 35 428 4.0E-28 T 21-04-2016 SPH21_RS19690 fc4f6f8795168801ba527d1737c4610a 431 SUPERFAMILY SSF56954 4 430 4.45E-47 T 21-04-2016 SPH21_RS19690 fc4f6f8795168801ba527d1737c4610a 431 PANTHER PTHR30203:SF4 36 428 9.6E-46 T 21-04-2016 SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 PANTHER PTHR30055 3 112 2.5E-16 T 21-04-2016 SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 1.5E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 1.5E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 4.7E-11 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 SUPERFAMILY SSF46689 7 81 4.98E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 Pfam PF13305 WHG domain 91 170 1.6E-15 T 21-04-2016 IPR025996 WHG domain SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 Gene3D G3DSA:1.10.357.10 5 179 2.6E-33 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS14070 cebef1b7ccb958ef58db141a2ee56569 199 SUPERFAMILY SSF48498 89 191 4.22E-15 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS12035 031e5521af39b09970ee568d06676820 134 Pfam PF01479 S4 domain 9 52 6.3E-12 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS12035 031e5521af39b09970ee568d06676820 134 Gene3D G3DSA:3.10.290.10 5 90 4.8E-28 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS12035 031e5521af39b09970ee568d06676820 134 SMART SM00363 8 71 2.3E-6 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS12035 031e5521af39b09970ee568d06676820 134 PIRSF PIRSF016821 5 130 3.0E-43 T 21-04-2016 IPR025708 Heat shock protein 15 GO:0003677|GO:0003727|GO:0034605|GO:0043023 SPH21_RS12035 031e5521af39b09970ee568d06676820 134 SUPERFAMILY SSF55174 5 89 9.96E-23 T 21-04-2016 SPH21_RS02105 5dc775de76ca528008a96b073d2a826d 264 Pfam PF13614 AAA domain 2 178 1.8E-68 T 21-04-2016 IPR025669 AAA domain SPH21_RS02105 5dc775de76ca528008a96b073d2a826d 264 PANTHER PTHR13696:SF52 1 261 1.1E-85 T 21-04-2016 SPH21_RS02105 5dc775de76ca528008a96b073d2a826d 264 SUPERFAMILY SSF52540 1 250 4.24E-64 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02105 5dc775de76ca528008a96b073d2a826d 264 Gene3D G3DSA:3.40.50.300 3 259 2.9E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02105 5dc775de76ca528008a96b073d2a826d 264 PANTHER PTHR13696 1 261 1.1E-85 T 21-04-2016 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 Gene3D G3DSA:3.50.50.60 5 176 6.1E-46 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 11 322 4.7E-29 T 21-04-2016 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 PANTHER PTHR23023 5 323 2.9E-71 T 21-04-2016 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 SUPERFAMILY SSF51905 238 328 4.83E-8 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 10 29 1.5E-5 T 21-04-2016 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 168 186 1.5E-5 T 21-04-2016 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 125 133 8.7E-14 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 164 188 8.7E-14 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 9 31 8.7E-14 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 Gene3D G3DSA:3.50.50.60 177 322 2.6E-8 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 SUPERFAMILY SSF51905 165 204 4.83E-8 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01125 fa1a9df9387a4c2e3eea5c48c8909bc8 354 SUPERFAMILY SSF51905 6 207 3.7E-44 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 Pfam PF00158 Sigma-54 interaction domain 232 398 7.0E-73 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 Gene3D G3DSA:1.10.8.60 405 477 2.7E-23 T 21-04-2016 SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 Gene3D G3DSA:3.40.50.300 229 404 2.7E-61 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 SUPERFAMILY SSF46689 445 542 1.84E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 SUPERFAMILY SSF55781 6 191 1.9E-9 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 PANTHER PTHR32071 196 544 6.8E-156 T 21-04-2016 SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 Gene3D G3DSA:1.10.10.60 492 539 5.4E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 SUPERFAMILY SSF52540 231 470 9.25E-73 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 256 269 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 Gene3D G3DSA:3.30.450.40 19 192 1.4E-9 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 445 454 - T 21-04-2016 IPR025944 Sigma-54 interaction domain, conserved site SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 SMART SM00382 252 396 1.4E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS24110 2f055433948d455c199ac1e26b90a313 548 Pfam PF02954 Bacterial regulatory protein, Fis family 496 540 1.1E-5 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS12130 ce1d836e8eb2f9874726e093cf3d8d5b 219 PANTHER PTHR14097 2 217 8.5E-55 T 21-04-2016 SPH21_RS12130 ce1d836e8eb2f9874726e093cf3d8d5b 219 Pfam PF13460 NAD(P)H-binding 8 154 4.2E-12 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12130 ce1d836e8eb2f9874726e093cf3d8d5b 219 PANTHER PTHR14097:SF7 2 217 8.5E-55 T 21-04-2016 SPH21_RS12130 ce1d836e8eb2f9874726e093cf3d8d5b 219 SUPERFAMILY SSF51735 1 210 1.67E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12130 ce1d836e8eb2f9874726e093cf3d8d5b 219 Gene3D G3DSA:3.40.50.720 1 218 2.3E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 Gene3D G3DSA:3.40.720.10 3 292 3.4E-39 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 5 371 3.6E-50 T 21-04-2016 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 SUPERFAMILY SSF53649 3 407 5.01E-63 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 Gene3D G3DSA:3.30.1360.110 293 357 4.0E-12 T 21-04-2016 IPR023116 Phosphonoacetate hydrolase, insert domain GO:0047400 SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 PANTHER PTHR10151:SF67 37 136 2.2E-62 T 21-04-2016 SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 PANTHER PTHR10151:SF67 271 339 2.2E-62 T 21-04-2016 SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 PANTHER PTHR10151:SF67 170 253 2.2E-62 T 21-04-2016 SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 PANTHER PTHR10151 37 136 2.2E-62 T 21-04-2016 IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 PANTHER PTHR10151 271 339 2.2E-62 T 21-04-2016 IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family SPH21_RS02195 8a8214952ddb3f9b368ff6545c8d9eb6 452 PANTHER PTHR10151 170 253 2.2E-62 T 21-04-2016 IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family SPH21_RS24525 12f76dc0d77190cd6e7fa396e4e89300 155 Gene3D G3DSA:1.20.120.450 28 150 6.0E-4 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS24525 12f76dc0d77190cd6e7fa396e4e89300 155 Pfam PF07609 Protein of unknown function (DUF1572) 29 153 2.8E-5 T 21-04-2016 IPR011466 Protein of unknown function DUF1572 SPH21_RS24525 12f76dc0d77190cd6e7fa396e4e89300 155 SUPERFAMILY SSF109854 13 151 5.31E-19 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 Gene3D G3DSA:2.40.50.100 61 91 2.9E-18 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 Gene3D G3DSA:2.40.50.100 236 270 2.9E-18 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 SUPERFAMILY SSF111369 198 308 5.23E-13 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 69 89 2.4E-10 T 21-04-2016 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 282 306 2.4E-10 T 21-04-2016 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 250 271 2.4E-10 T 21-04-2016 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 357 370 2.4E-10 T 21-04-2016 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 PANTHER PTHR30386:SF0 21 370 6.6E-88 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 SUPERFAMILY SSF111369 131 189 3.27E-6 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 SUPERFAMILY SSF111369 59 134 4.45E-12 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 Pfam PF13533 Biotin-lipoyl like 61 106 4.9E-15 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 Pfam PF13437 HlyD family secretion protein 238 320 1.4E-17 T 21-04-2016 SPH21_RS08290 d901b77e6cc33e76e43e4b67dc114bb1 370 PANTHER PTHR30386 21 370 6.6E-88 T 21-04-2016 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Gene3D G3DSA:3.20.20.80 155 522 1.1E-94 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 SMART SM00642 159 514 1.7E-8 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 TIGRFAM TIGR01515 branching_enzym: 1,4-alpha-glucan branching enzyme 17 636 1.7E-259 T 21-04-2016 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 SUPERFAMILY SSF51011 534 638 6.47E-31 T 21-04-2016 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 SUPERFAMILY SSF81296 45 104 2.1E-9 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Gene3D G3DSA:2.60.40.1180 534 637 8.8E-34 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Gene3D G3DSA:2.60.40.10 21 129 3.0E-36 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Pfam PF00128 Alpha amylase, catalytic domain 188 258 2.9E-8 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Pfam PF00128 Alpha amylase, catalytic domain 288 491 1.1E-4 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 PANTHER PTHR10357 16 637 0.0 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Hamap MF_00685 1,4-alpha-glucan branching enzyme GlgB [glgB]. 13 638 42.778 T 21-04-2016 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 32 116 2.4E-23 T 21-04-2016 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 Pfam PF02806 Alpha amylase, C-terminal all-beta domain 539 637 1.9E-19 T 21-04-2016 IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: REACT_474 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 SUPERFAMILY SSF51445 93 527 5.76E-114 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 PIRSF PIRSF000463 3 641 1.2E-272 T 21-04-2016 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS10725 2c82c64ca2d5ea354bdc040f734b3d82 641 PANTHER PTHR10357:SF160 16 637 0.0 T 21-04-2016 SPH21_RS17190 9cfae66c9e19cc82b765c41a3a78ba9b 306 SUPERFAMILY SSF51658 53 292 4.58E-49 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS17190 9cfae66c9e19cc82b765c41a3a78ba9b 306 Pfam PF01261 Xylose isomerase-like TIM barrel 69 251 1.7E-19 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS17190 9cfae66c9e19cc82b765c41a3a78ba9b 306 PIRSF PIRSF006241 39 303 3.9E-68 T 21-04-2016 IPR026040 Hydroxypyruvate isomerase-like KEGG: 00630+5.3.1.22 SPH21_RS17190 9cfae66c9e19cc82b765c41a3a78ba9b 306 Gene3D G3DSA:3.20.20.150 44 300 5.4E-54 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS17190 9cfae66c9e19cc82b765c41a3a78ba9b 306 PANTHER PTHR12110 57 306 4.3E-36 T 21-04-2016 SPH21_RS02460 731228738f236a686de00eed586b873a 626 Gene3D G3DSA:1.25.40.10 424 491 6.4E-41 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02460 731228738f236a686de00eed586b873a 626 Gene3D G3DSA:1.25.40.10 540 558 6.4E-41 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02460 731228738f236a686de00eed586b873a 626 Gene3D G3DSA:1.25.40.10 199 331 6.4E-41 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02460 731228738f236a686de00eed586b873a 626 SUPERFAMILY SSF48452 387 491 2.21E-102 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02460 731228738f236a686de00eed586b873a 626 SUPERFAMILY SSF48452 21 352 2.21E-102 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02460 731228738f236a686de00eed586b873a 626 SUPERFAMILY SSF48452 542 626 2.21E-102 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02460 731228738f236a686de00eed586b873a 626 Pfam PF14322 Starch-binding associating with outer membrane 40 219 8.8E-25 T 21-04-2016 SPH21_RS02460 731228738f236a686de00eed586b873a 626 Pfam PF07980 SusD family 274 626 4.4E-51 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04150 cd594db578542181954e6a65fea05188 793 Pfam PF12704 MacB-like periplasmic core domain 434 631 7.0E-7 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS04150 cd594db578542181954e6a65fea05188 793 Pfam PF12704 MacB-like periplasmic core domain 20 242 1.6E-16 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS04150 cd594db578542181954e6a65fea05188 793 Pfam PF02687 FtsX-like permease family 291 407 6.6E-15 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS04150 cd594db578542181954e6a65fea05188 793 Pfam PF02687 FtsX-like permease family 673 786 9.4E-14 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS04150 cd594db578542181954e6a65fea05188 793 PANTHER PTHR30572:SF4 411 793 3.3E-81 T 21-04-2016 SPH21_RS04150 cd594db578542181954e6a65fea05188 793 PANTHER PTHR30572:SF4 296 357 3.3E-81 T 21-04-2016 SPH21_RS04150 cd594db578542181954e6a65fea05188 793 PANTHER PTHR30572 411 793 3.3E-81 T 21-04-2016 SPH21_RS04150 cd594db578542181954e6a65fea05188 793 PANTHER PTHR30572 296 357 3.3E-81 T 21-04-2016 SPH21_RS10345 12241eaee0342db7504809fe8222973b 172 Pfam PF13648 Lipocalin-like domain 66 152 1.4E-6 T 21-04-2016 IPR024311 Lipocalin-like domain SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 Gene3D G3DSA:2.40.170.20 319 398 5.0E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 Gene3D G3DSA:2.40.170.20 434 787 5.0E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 34 1022 1.3E-204 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 SUPERFAMILY SSF56935 454 787 6.96E-84 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 SUPERFAMILY SSF56935 319 408 6.96E-84 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 SUPERFAMILY SSF56935 933 1022 6.96E-84 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 SUPERFAMILY SSF56935 112 277 6.96E-84 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 SUPERFAMILY SSF56935 844 887 6.96E-84 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 Pfam PF14905 Outer membrane protein beta-barrel family 693 806 3.5E-8 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069:SF11 932 1022 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069:SF11 18 542 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069:SF11 562 832 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069:SF11 855 895 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 Pfam PF07715 TonB-dependent Receptor Plug Domain 127 253 5.6E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 Gene3D G3DSA:2.170.130.10 116 257 4.1E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069 932 1022 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069 18 542 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069 562 832 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 PANTHER PTHR30069 855 895 2.9E-226 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 Pfam PF13715 CarboxypepD_reg-like domain 35 118 3.0E-17 T 21-04-2016 SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 SUPERFAMILY SSF49464 34 116 1.26E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 Gene3D G3DSA:2.60.40.1120 34 107 1.3E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS01895 d14946ec07c2dfb37ff52746900a03f6 1022 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 229 259 1.8E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13315 811bd06f982ee1879f4b3b581a3af844 408 SUPERFAMILY SSF103473 9 403 9.29E-35 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13315 811bd06f982ee1879f4b3b581a3af844 408 PANTHER PTHR23522 7 401 1.7E-114 T 21-04-2016 SPH21_RS13315 811bd06f982ee1879f4b3b581a3af844 408 Gene3D G3DSA:1.20.1250.20 207 405 6.0E-23 T 21-04-2016 SPH21_RS13315 811bd06f982ee1879f4b3b581a3af844 408 Gene3D G3DSA:1.20.1250.20 7 198 3.0E-14 T 21-04-2016 SPH21_RS13315 811bd06f982ee1879f4b3b581a3af844 408 Pfam PF03825 Nucleoside H+ symporter 4 402 1.5E-103 T 21-04-2016 SPH21_RS13315 811bd06f982ee1879f4b3b581a3af844 408 PANTHER PTHR23522:SF1 7 401 1.7E-114 T 21-04-2016 SPH21_RS23595 b9dbe5cd50baab337fd9d370dcc0db58 302 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 22 46 - T 21-04-2016 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SPH21_RS23595 b9dbe5cd50baab337fd9d370dcc0db58 302 Pfam PF00294 pfkB family carbohydrate kinase 3 280 1.9E-47 T 21-04-2016 IPR011611 Carbohydrate kinase PfkB SPH21_RS23595 b9dbe5cd50baab337fd9d370dcc0db58 302 PANTHER PTHR10584 1 288 1.3E-60 T 21-04-2016 SPH21_RS23595 b9dbe5cd50baab337fd9d370dcc0db58 302 PANTHER PTHR10584:SF188 1 288 1.3E-60 T 21-04-2016 SPH21_RS23595 b9dbe5cd50baab337fd9d370dcc0db58 302 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 236 249 - T 21-04-2016 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SPH21_RS23595 b9dbe5cd50baab337fd9d370dcc0db58 302 SUPERFAMILY SSF53613 1 290 1.26E-60 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS23595 b9dbe5cd50baab337fd9d370dcc0db58 302 Gene3D G3DSA:3.40.1190.20 1 292 2.2E-65 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PANTHER PTHR30050 4 107 9.1E-189 T 21-04-2016 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PANTHER PTHR30050 137 476 9.1E-189 T 21-04-2016 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 Gene3D G3DSA:1.10.8.60 306 373 4.1E-28 T 21-04-2016 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 SMART SM00382 172 300 1.1E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 SUPERFAMILY SSF48295 370 474 4.97E-35 T 21-04-2016 IPR010921 Trp repressor/replication initiator GO:0043565 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 SUPERFAMILY SSF52540 138 348 2.15E-40 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 173 193 9.8E-43 T 21-04-2016 IPR020591 Chromosomal replication control, initiator DnaA-like SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 205 219 9.8E-43 T 21-04-2016 IPR020591 Chromosomal replication control, initiator DnaA-like SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 237 251 9.8E-43 T 21-04-2016 IPR020591 Chromosomal replication control, initiator DnaA-like SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 271 298 9.8E-43 T 21-04-2016 IPR020591 Chromosomal replication control, initiator DnaA-like SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 433 452 9.8E-43 T 21-04-2016 IPR020591 Chromosomal replication control, initiator DnaA-like SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 ProSitePatterns PS01008 DnaA protein signature. 433 452 - T 21-04-2016 IPR018312 Chromosomal replication control, initiator DnaA, conserved site GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PANTHER PTHR30050:SF2 4 107 9.1E-189 T 21-04-2016 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 PANTHER PTHR30050:SF2 137 476 9.1E-189 T 21-04-2016 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 TIGRFAM TIGR00362 DnaA: chromosomal replication initiator protein DnaA 9 473 1.2E-160 T 21-04-2016 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 Gene3D G3DSA:3.40.50.300 131 303 4.5E-56 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 Pfam PF08299 Bacterial dnaA protein helix-turn-helix 384 452 3.6E-30 T 21-04-2016 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 Pfam PF00308 Bacterial dnaA protein 139 356 2.4E-85 T 21-04-2016 IPR013317 Chromosomal replication initiator protein DnaA SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 Pfam PF11638 DnaA N-terminal domain 7 67 5.0E-17 T 21-04-2016 IPR024633 DnaA N-terminal domain SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 Gene3D G3DSA:1.10.1750.10 374 474 1.0E-38 T 21-04-2016 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 Hamap MF_00377 Chromosomal replication initiator protein DnaA [dnaA]. 6 474 30.893 T 21-04-2016 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 SPH21_RS00010 1ffefcb6b0563e3bbc755a0bb3dade03 476 SMART SM00760 383 452 4.4E-35 T 21-04-2016 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 SUPERFAMILY SSF54211 628 802 1.82E-54 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS14855 4110475158ad493df83ef4012434e456 818 Hamap MF_01973 Lon protease [lon]. 43 804 68.449 T 21-04-2016 IPR027543 Lon protease, bacterial GO:0004176|GO:0004252|GO:0005524|GO:0006508|GO:0043565 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 384 521 6.1E-22 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 SMART SM00464 42 235 1.8E-51 T 21-04-2016 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 602 804 6.6E-86 T 21-04-2016 IPR008269 Peptidase S16, Lon C-terminal GO:0004176|GO:0004252|GO:0006508 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 SMART SM00382 380 538 3.7E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PANTHER PTHR10046 16 808 0.0 T 21-04-2016 IPR027065 Lon protease GO:0004176|GO:0004252|GO:0005524|GO:0030163 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 SUPERFAMILY SSF88697 42 233 4.97E-45 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS14855 4110475158ad493df83ef4012434e456 818 Gene3D G3DSA:1.10.8.60 534 616 1.7E-27 T 21-04-2016 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain 43 233 1.3E-38 T 21-04-2016 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 SUPERFAMILY SSF52540 342 620 2.37E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PANTHER PTHR10046:SF24 16 808 0.0 T 21-04-2016 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 627 643 6.6E-52 T 21-04-2016 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 705 724 6.6E-52 T 21-04-2016 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 735 754 6.6E-52 T 21-04-2016 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 758 776 6.6E-52 T 21-04-2016 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 388 407 6.6E-52 T 21-04-2016 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 TIGRFAM TIGR00763 lon: endopeptidase La 45 803 7.1E-283 T 21-04-2016 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 Gene3D G3DSA:3.30.230.10 623 802 1.6E-70 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS14855 4110475158ad493df83ef4012434e456 818 ProSitePatterns PS01046 ATP-dependent serine proteases, lon family, serine active site. 708 716 - T 21-04-2016 IPR008268 Peptidase S16, active site GO:0004176|GO:0004252|GO:0006508 SPH21_RS14855 4110475158ad493df83ef4012434e456 818 Gene3D G3DSA:3.40.50.300 340 533 7.8E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14855 4110475158ad493df83ef4012434e456 818 PIRSF PIRSF001174 28 807 3.4E-303 T 21-04-2016 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 SPH21_RS00345 d73c3ed87700d894f0ab9e24eab968bf 275 Gene3D G3DSA:3.40.50.1820 6 273 4.0E-61 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00345 d73c3ed87700d894f0ab9e24eab968bf 275 SUPERFAMILY SSF53474 4 273 2.14E-56 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00345 d73c3ed87700d894f0ab9e24eab968bf 275 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 2.1E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS00345 d73c3ed87700d894f0ab9e24eab968bf 275 PRINTS PR00111 Alpha/beta hydrolase fold signature 56 71 2.1E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS00345 d73c3ed87700d894f0ab9e24eab968bf 275 PRINTS PR00111 Alpha/beta hydrolase fold signature 217 231 2.1E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS00345 d73c3ed87700d894f0ab9e24eab968bf 275 PANTHER PTHR10992 7 273 5.5E-57 T 21-04-2016 SPH21_RS00345 d73c3ed87700d894f0ab9e24eab968bf 275 Pfam PF00561 alpha/beta hydrolase fold 32 260 1.0E-24 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 Gene3D G3DSA:1.10.10.10 13 74 6.0E-9 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 PANTHER PTHR18964:SF123 56 390 9.2E-61 T 21-04-2016 SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 SUPERFAMILY SSF46785 10 72 2.15E-8 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 SUPERFAMILY SSF53067 81 390 1.35E-50 T 21-04-2016 SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 Gene3D G3DSA:3.30.420.40 216 372 4.1E-44 T 21-04-2016 SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 Pfam PF00480 ROK family 120 388 5.8E-47 T 21-04-2016 IPR000600 ROK family SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 Gene3D G3DSA:3.30.420.40 79 215 3.2E-26 T 21-04-2016 SPH21_RS11090 9fa4a75ffbf6d5ee85b93bf0d014660c 393 PANTHER PTHR18964 56 390 9.2E-61 T 21-04-2016 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 SUPERFAMILY SSF55347 292 457 2.02E-48 T 21-04-2016 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 PANTHER PTHR10836:SF35 118 481 8.1E-165 T 21-04-2016 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 249 262 1.6E-12 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 369 386 1.6E-12 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 286 304 1.6E-12 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 313 329 1.6E-12 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 SUPERFAMILY SSF51735 131 308 5.21E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 131 292 5.5E-37 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 Gene3D G3DSA:3.40.50.720 131 300 1.7E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 Gene3D G3DSA:3.30.360.10 301 458 8.5E-53 T 21-04-2016 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 PANTHER PTHR10836 118 481 8.1E-165 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 SMART SM00846 130 292 1.4E-41 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS16200 a266ad10ee3792211f91786113e8d158 482 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 297 456 1.1E-44 T 21-04-2016 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS15390 e9d12532c3a855e3eef14acd643bbd1d 324 PANTHER PTHR12001 11 324 2.2E-97 T 21-04-2016 IPR017446 Polyprenyl synthetase-related SPH21_RS15390 e9d12532c3a855e3eef14acd643bbd1d 324 Gene3D G3DSA:1.10.600.10 13 323 6.1E-92 T 21-04-2016 IPR008949 Isoprenoid synthase domain SPH21_RS15390 e9d12532c3a855e3eef14acd643bbd1d 324 Pfam PF00348 Polyprenyl synthetase 26 273 2.4E-73 T 21-04-2016 IPR000092 Polyprenyl synthetase GO:0008299 SPH21_RS15390 e9d12532c3a855e3eef14acd643bbd1d 324 PANTHER PTHR12001:SF23 11 324 2.2E-97 T 21-04-2016 SPH21_RS15390 e9d12532c3a855e3eef14acd643bbd1d 324 SUPERFAMILY SSF48576 19 321 6.77E-88 T 21-04-2016 IPR008949 Isoprenoid synthase domain SPH21_RS15390 e9d12532c3a855e3eef14acd643bbd1d 324 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 76 90 - T 21-04-2016 IPR000092 Polyprenyl synthetase GO:0008299 SPH21_RS15390 e9d12532c3a855e3eef14acd643bbd1d 324 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 201 213 - T 21-04-2016 IPR000092 Polyprenyl synthetase GO:0008299 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 PANTHER PTHR11271 531 966 3.5E-25 T 21-04-2016 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 Gene3D G3DSA:2.30.40.10 29 153 1.7E-15 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 Gene3D G3DSA:2.30.40.10 558 669 1.4E-24 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 SUPERFAMILY SSF51556 282 389 6.39E-5 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 Pfam PF01979 Amidohydrolase family 349 403 2.8E-7 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 Pfam PF01979 Amidohydrolase family 850 931 1.8E-10 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 SUPERFAMILY SSF51338 388 419 2.4E-11 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 SUPERFAMILY SSF51338 24 89 2.4E-11 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 PANTHER PTHR11271:SF39 531 966 3.5E-25 T 21-04-2016 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 SUPERFAMILY SSF51338 905 941 6.95E-23 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 SUPERFAMILY SSF51338 546 619 6.95E-23 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 Gene3D G3DSA:2.30.40.10 329 408 3.4E-13 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 Gene3D G3DSA:2.30.40.10 847 940 3.1E-22 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS03830 df0d12899c2bb5deae95c5540be229ea 1000 SUPERFAMILY SSF51556 619 906 9.53E-20 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 SUPERFAMILY SSF46785 11 95 1.27E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 68 83 5.8E-8 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 53 68 5.8E-8 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 20 35 5.8E-8 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 Gene3D G3DSA:1.10.10.10 5 98 2.7E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 Pfam PF01022 Bacterial regulatory protein, arsR family 25 70 4.1E-11 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 SMART SM00418 18 100 2.4E-14 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 PANTHER PTHR33154:SF6 11 109 3.4E-16 T 21-04-2016 SPH21_RS01150 d0c96e31bfa1488ff14371bdb0e18a51 109 PANTHER PTHR33154 11 109 3.4E-16 T 21-04-2016 SPH21_RS19550 438aa04b5d07d211f1da61f4ed8d9fb1 372 Pfam PF00534 Glycosyl transferases group 1 161 341 7.8E-21 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS19550 438aa04b5d07d211f1da61f4ed8d9fb1 372 PANTHER PTHR12526 49 192 1.1E-27 T 21-04-2016 SPH21_RS19550 438aa04b5d07d211f1da61f4ed8d9fb1 372 PANTHER PTHR12526 219 371 1.1E-27 T 21-04-2016 SPH21_RS19550 438aa04b5d07d211f1da61f4ed8d9fb1 372 SUPERFAMILY SSF53756 22 197 1.22E-48 T 21-04-2016 SPH21_RS19550 438aa04b5d07d211f1da61f4ed8d9fb1 372 SUPERFAMILY SSF53756 227 369 1.22E-48 T 21-04-2016 SPH21_RS19550 438aa04b5d07d211f1da61f4ed8d9fb1 372 Gene3D G3DSA:3.40.50.2000 120 340 3.9E-20 T 21-04-2016 SPH21_RS19550 438aa04b5d07d211f1da61f4ed8d9fb1 372 Pfam PF13439 Glycosyltransferase Family 4 25 136 3.2E-14 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 SUPERFAMILY SSF49464 12 85 2.9E-10 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 Gene3D G3DSA:2.40.170.20 212 817 4.4E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 Gene3D G3DSA:2.170.130.10 93 211 3.3E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 Pfam PF13715 CarboxypepD_reg-like domain 12 94 9.0E-16 T 21-04-2016 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 PANTHER PTHR32552 90 676 5.3E-111 T 21-04-2016 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 PANTHER PTHR32552 693 817 5.3E-111 T 21-04-2016 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 Pfam PF07715 TonB-dependent Receptor Plug Domain 102 209 3.2E-10 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 PANTHER PTHR32552:SF38 90 676 5.3E-111 T 21-04-2016 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 PANTHER PTHR32552:SF38 693 817 5.3E-111 T 21-04-2016 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 SUPERFAMILY SSF56935 84 817 4.03E-76 T 21-04-2016 SPH21_RS06135 376bc0075795dfb707a04ec21d94ab88 817 Gene3D G3DSA:2.60.40.1120 12 92 1.3E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 Gene3D G3DSA:3.40.50.1820 37 333 4.2E-68 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 SUPERFAMILY SSF53474 49 335 9.23E-61 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PANTHER PTHR10992:SF771 1 282 1.8E-67 T 21-04-2016 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PANTHER PTHR10992:SF771 298 335 1.8E-67 T 21-04-2016 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 Pfam PF00561 alpha/beta hydrolase fold 70 170 3.3E-24 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PANTHER PTHR10992 1 282 1.8E-67 T 21-04-2016 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PANTHER PTHR10992 298 335 1.8E-67 T 21-04-2016 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00412 Epoxide hydrolase signature 141 154 9.3E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00412 Epoxide hydrolase signature 155 168 9.3E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00412 Epoxide hydrolase signature 96 111 9.3E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00412 Epoxide hydrolase signature 310 332 9.3E-7 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00111 Alpha/beta hydrolase fold signature 96 111 1.0E-13 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00111 Alpha/beta hydrolase fold signature 155 168 1.0E-13 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00111 Alpha/beta hydrolase fold signature 263 277 1.0E-13 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS16610 37c4ee27317fb28410c716983be8ff03 335 PRINTS PR00111 Alpha/beta hydrolase fold signature 141 154 1.0E-13 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22990 6378279241b7ca9d6296d3c7d7487bae 460 SUPERFAMILY SSF52096 27 200 5.1E-20 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS22990 6378279241b7ca9d6296d3c7d7487bae 460 Gene3D G3DSA:3.90.226.10 179 210 1.0E-15 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS22990 6378279241b7ca9d6296d3c7d7487bae 460 Gene3D G3DSA:3.90.226.10 46 134 1.0E-15 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS22990 6378279241b7ca9d6296d3c7d7487bae 460 PANTHER PTHR33507:SF1 3 456 3.8E-83 T 21-04-2016 SPH21_RS22990 6378279241b7ca9d6296d3c7d7487bae 460 Pfam PF01957 NfeD-like C-terminal, partner-binding 291 454 1.5E-13 T 21-04-2016 IPR002810 NfeD-like, C-terminal domain SPH21_RS22990 6378279241b7ca9d6296d3c7d7487bae 460 Pfam PF01972 Serine dehydrogenase proteinase 69 142 2.3E-6 T 21-04-2016 IPR002825 Peptidase S49, serine-peptidase prokaryotes GO:0016021 SPH21_RS22990 6378279241b7ca9d6296d3c7d7487bae 460 PANTHER PTHR33507 3 456 3.8E-83 T 21-04-2016 SPH21_RS14950 83884b58ec652bc2e5577679f8ab13b6 261 Pfam PF00877 NlpC/P60 family 148 240 4.6E-20 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS14950 83884b58ec652bc2e5577679f8ab13b6 261 PANTHER PTHR21666 140 244 1.6E-19 T 21-04-2016 SPH21_RS14950 83884b58ec652bc2e5577679f8ab13b6 261 SUPERFAMILY SSF54001 132 260 1.11E-28 T 21-04-2016 SPH21_RS14950 83884b58ec652bc2e5577679f8ab13b6 261 Gene3D G3DSA:3.90.1720.10 139 260 4.0E-30 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 SUPERFAMILY SSF52540 406 469 9.11E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 SUPERFAMILY SSF52540 259 358 9.11E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 SUPERFAMILY SSF52540 151 217 9.11E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 SUPERFAMILY SSF52540 3 168 2.53E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 Gene3D G3DSA:3.40.50.300 4 215 1.9E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 Pfam PF13604 AAA domain 17 215 5.5E-27 T 21-04-2016 SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 Gene3D G3DSA:3.40.50.300 256 291 4.9E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 Gene3D G3DSA:3.40.50.300 406 464 4.9E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 Pfam PF13538 UvrD-like helicase C-terminal domain 415 464 1.6E-18 T 21-04-2016 IPR027785 UvrD-like helicase C-terminal domain SPH21_RS15715 6b7da6c4a6258535fd94c885a129a82e 473 Gene3D G3DSA:3.40.50.300 301 405 3.5E-4 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 Hamap MF_00218 Uroporphyrinogen decarboxylase [hemE]. 3 340 45.415 T 21-04-2016 IPR006361 Uroporphyrinogen decarboxylase HemE GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 Gene3D G3DSA:3.20.20.210 2 340 1.3E-127 T 21-04-2016 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 ProSitePatterns PS00906 Uroporphyrinogen decarboxylase signature 1. 19 28 - T 21-04-2016 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 TIGRFAM TIGR01464 hemE: uroporphyrinogen decarboxylase 6 338 6.8E-125 T 21-04-2016 IPR006361 Uroporphyrinogen decarboxylase HemE GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 PANTHER PTHR21091:SF2 13 341 2.8E-124 T 21-04-2016 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 SUPERFAMILY SSF51726 5 340 1.06E-105 T 21-04-2016 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 ProSitePatterns PS00907 Uroporphyrinogen decarboxylase signature 2. 137 153 - T 21-04-2016 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 Pfam PF01208 Uroporphyrinogen decarboxylase (URO-D) 3 339 4.0E-121 T 21-04-2016 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS25555 7676e5e5578e680c9ffbe976d77b6848 341 PANTHER PTHR21091 13 341 2.8E-124 T 21-04-2016 SPH21_RS11545 12471ae2bf63aa18d863c808c0354a18 381 PANTHER PTHR24023 44 381 2.2E-42 T 21-04-2016 SPH21_RS11545 12471ae2bf63aa18d863c808c0354a18 381 PANTHER PTHR24023:SF593 44 381 2.2E-42 T 21-04-2016 SPH21_RS11545 12471ae2bf63aa18d863c808c0354a18 381 SUPERFAMILY SSF89796 1 378 2.35E-99 T 21-04-2016 IPR023606 CoA-transferase family III domain SPH21_RS11545 12471ae2bf63aa18d863c808c0354a18 381 Gene3D G3DSA:3.30.1540.10 236 303 7.2E-6 T 21-04-2016 SPH21_RS11545 12471ae2bf63aa18d863c808c0354a18 381 Pfam PF02515 CoA-transferase family III 4 371 4.5E-95 T 21-04-2016 IPR003673 CoA-transferase family III GO:0003824 SPH21_RS11545 12471ae2bf63aa18d863c808c0354a18 381 Gene3D G3DSA:3.40.50.10540 304 378 4.0E-92 T 21-04-2016 IPR023606 CoA-transferase family III domain SPH21_RS11545 12471ae2bf63aa18d863c808c0354a18 381 Gene3D G3DSA:3.40.50.10540 2 217 4.0E-92 T 21-04-2016 IPR023606 CoA-transferase family III domain SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 PANTHER PTHR11124 95 241 1.3E-44 T 21-04-2016 IPR000979 Phosphodiesterase MJ0936/Vps29 SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 PANTHER PTHR11124 1 74 1.3E-44 T 21-04-2016 IPR000979 Phosphodiesterase MJ0936/Vps29 SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 PANTHER PTHR11124:SF2 95 241 1.3E-44 T 21-04-2016 SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 PANTHER PTHR11124:SF2 1 74 1.3E-44 T 21-04-2016 SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 PIRSF PIRSF000883 1 244 2.3E-50 T 21-04-2016 IPR011152 Phosphoesterase MJ0912 SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 SUPERFAMILY SSF56300 1 241 4.38E-50 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 1 198 2.9E-28 T 21-04-2016 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type SPH21_RS01115 3d36620e40955b301b4df8a566bd2144 244 Gene3D G3DSA:3.60.21.10 1 243 1.9E-66 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 SUPERFAMILY SSF101904 508 827 1.96E-101 T 21-04-2016 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 SMART SM00434 21 474 2.2E-280 T 21-04-2016 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 PANTHER PTHR10169 15 791 0.0 T 21-04-2016 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 PANTHER PTHR10169:SF48 15 791 0.0 T 21-04-2016 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 42 481 2.1E-161 T 21-04-2016 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 SUPERFAMILY SSF56719 40 497 1.02E-179 T 21-04-2016 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Hamap MF_01897 DNA gyrase subunit A [gyrA]. 13 825 29.459 T 21-04-2016 IPR005743 DNA gyrase, subunit A GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 TIGRFAM TIGR01063 gyrA: DNA gyrase, A subunit 18 821 0.0 T 21-04-2016 IPR005743 DNA gyrase, subunit A GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 726 770 2.7E-12 T 21-04-2016 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 514 557 1.4E-9 T 21-04-2016 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 679 720 5.6E-10 T 21-04-2016 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 625 663 5.9E-5 T 21-04-2016 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 775 821 6.7E-14 T 21-04-2016 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 564 606 2.5E-4 T 21-04-2016 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Gene3D G3DSA:3.30.1360.40 246 342 1.4E-37 T 21-04-2016 IPR024946 Arginine repressor C-terminal-like domain SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Gene3D G3DSA:2.120.10.90 505 821 3.5E-121 T 21-04-2016 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Gene3D G3DSA:3.90.199.10 40 245 8.6E-122 T 21-04-2016 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 SPH21_RS16735 95b100527247c26ccb015ebbbdb34a19 862 Gene3D G3DSA:3.90.199.10 343 408 8.6E-122 T 21-04-2016 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 SPH21_RS24105 1c62a4b4368fc433725241f54b440f08 328 Gene3D G3DSA:3.40.50.1820 5 327 1.6E-87 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24105 1c62a4b4368fc433725241f54b440f08 328 ProSitePatterns PS01173 Lipolytic enzymes "G-D-X-G" family, putative histidine active site. 92 108 - T 21-04-2016 IPR002168 Lipase, GDXG, putative histidine active site GO:0008152|GO:0016787 SPH21_RS24105 1c62a4b4368fc433725241f54b440f08 328 Pfam PF07859 alpha/beta hydrolase fold 93 299 3.3E-67 T 21-04-2016 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SPH21_RS24105 1c62a4b4368fc433725241f54b440f08 328 SUPERFAMILY SSF53474 39 326 3.44E-64 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24105 1c62a4b4368fc433725241f54b440f08 328 PANTHER PTHR23024:SF128 61 328 1.9E-91 T 21-04-2016 SPH21_RS24105 1c62a4b4368fc433725241f54b440f08 328 PANTHER PTHR23024 61 328 1.9E-91 T 21-04-2016 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 SUPERFAMILY SSF52161 6 144 8.37E-59 T 21-04-2016 IPR023564 Ribosomal protein L13 domain GO:0003735|GO:0005840|GO:0006412 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 PANTHER PTHR11545 5 142 1.3E-73 T 21-04-2016 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 Hamap MF_01366 50S ribosomal protein L13 [rplM]. 20 146 28.985 T 21-04-2016 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 PIRSF PIRSF002181 4 147 2.4E-51 T 21-04-2016 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 TIGRFAM TIGR01066 rplM_bact: ribosomal protein uL13 10 145 2.4E-59 T 21-04-2016 IPR005823 Ribosomal protein L13, bacterial-type GO:0003735|GO:0005840|GO:0006412 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 Pfam PF00572 Ribosomal protein L13 19 143 2.1E-56 T 21-04-2016 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 Gene3D G3DSA:3.90.1180.10 9 146 9.7E-63 T 21-04-2016 IPR023564 Ribosomal protein L13 domain GO:0003735|GO:0005840|GO:0006412 SPH21_RS07125 8c1fa55cb89240302bb621e4a38f8b29 147 ProSitePatterns PS00783 Ribosomal protein L13 signature. 110 132 - T 21-04-2016 IPR023563 Ribosomal protein L13, conserved site GO:0003735|GO:0005840|GO:0006412 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 309 338 1.0E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Gene3D G3DSA:2.60.40.1120 135 221 2.8E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 135 1118 7.9E-278 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 SUPERFAMILY SSF49464 135 215 1.57E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 PANTHER PTHR11532:SF57 605 1116 6.8E-266 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 PANTHER PTHR11532:SF57 132 528 6.8E-266 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 PANTHER PTHR11532 605 1116 6.8E-266 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 PANTHER PTHR11532 132 528 6.8E-266 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Pfam PF13715 CarboxypepD_reg-like domain 135 217 2.0E-19 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Pfam PF07715 TonB-dependent Receptor Plug Domain 225 332 3.0E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Gene3D G3DSA:2.170.130.10 222 332 4.8E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Gene3D G3DSA:2.40.170.20 534 895 2.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Gene3D G3DSA:2.40.170.20 1027 1118 2.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Gene3D G3DSA:2.40.170.20 416 488 2.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Gene3D G3DSA:2.40.170.20 333 344 2.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 Gene3D G3DSA:2.40.170.20 955 994 2.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 SUPERFAMILY SSF56935 532 873 3.16E-98 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 SUPERFAMILY SSF56935 945 989 3.16E-98 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 SUPERFAMILY SSF56935 211 356 3.16E-98 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 SUPERFAMILY SSF56935 414 502 3.16E-98 T 21-04-2016 SPH21_RS23680 cb193a4a9529135d2904fc27d69dc1f2 1118 SUPERFAMILY SSF56935 1030 1118 3.16E-98 T 21-04-2016 SPH21_RS04040 1395ee1dc32a2686d188799525e20d16 283 Pfam PF12833 Helix-turn-helix domain 200 278 3.5E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04040 1395ee1dc32a2686d188799525e20d16 283 PANTHER PTHR11019:SF45 48 283 1.6E-30 T 21-04-2016 SPH21_RS04040 1395ee1dc32a2686d188799525e20d16 283 PANTHER PTHR11019 48 283 1.6E-30 T 21-04-2016 SPH21_RS04040 1395ee1dc32a2686d188799525e20d16 283 SMART SM00342 194 277 1.7E-10 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04040 1395ee1dc32a2686d188799525e20d16 283 SUPERFAMILY SSF46689 233 278 1.75E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04040 1395ee1dc32a2686d188799525e20d16 283 Gene3D G3DSA:1.10.10.60 234 280 8.9E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 PIRSF PIRSF001359 10 356 3.6E-89 T 21-04-2016 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 Pfam PF01116 Fructose-bisphosphate aldolase class-II 15 353 4.8E-88 T 21-04-2016 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 ProSitePatterns PS00602 Fructose-bisphosphate aldolase class-II signature 1. 97 108 - T 21-04-2016 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 Gene3D G3DSA:3.20.20.70 8 354 2.3E-122 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 TIGRFAM TIGR01520 FruBisAldo_II_A: fructose-bisphosphate aldolase, class II 7 355 4.3E-170 T 21-04-2016 IPR006411 Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype GO:0004332|GO:0006096 KEGG: 00010+4.1.2.13|KEGG: 00030+4.1.2.13|KEGG: 00051+4.1.2.13|KEGG: 00680+4.1.2.13|KEGG: 00710+4.1.2.13|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 TIGRFAM TIGR00167 cbbA: ketose-bisphosphate aldolase 12 354 1.2E-107 T 21-04-2016 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 SUPERFAMILY SSF51569 7 353 8.79E-128 T 21-04-2016 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 PANTHER PTHR30559:SF0 1 357 4.4E-224 T 21-04-2016 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 ProSitePatterns PS00806 Fructose-bisphosphate aldolase class-II signature 2. 168 179 - T 21-04-2016 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SPH21_RS19820 7e72ef9cb561da4500e64dbc4e67217e 359 PANTHER PTHR30559 1 357 4.4E-224 T 21-04-2016 SPH21_RS08915 7758b7b020e2a3a5fef34f314768a4e4 372 Pfam PF13439 Glycosyltransferase Family 4 50 169 2.2E-13 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS08915 7758b7b020e2a3a5fef34f314768a4e4 372 PANTHER PTHR12526 2 358 2.7E-34 T 21-04-2016 SPH21_RS08915 7758b7b020e2a3a5fef34f314768a4e4 372 Gene3D G3DSA:3.40.50.2000 152 302 1.3E-14 T 21-04-2016 SPH21_RS08915 7758b7b020e2a3a5fef34f314768a4e4 372 PANTHER PTHR12526:SF399 2 358 2.7E-34 T 21-04-2016 SPH21_RS08915 7758b7b020e2a3a5fef34f314768a4e4 372 Pfam PF00534 Glycosyl transferases group 1 177 300 1.8E-18 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS08915 7758b7b020e2a3a5fef34f314768a4e4 372 SUPERFAMILY SSF53756 1 356 8.07E-50 T 21-04-2016 SPH21_RS02215 1cd9187d8d71b9e835a2bc192816daab 328 Gene3D G3DSA:3.20.20.140 25 283 7.0E-36 T 21-04-2016 SPH21_RS02215 1cd9187d8d71b9e835a2bc192816daab 328 SUPERFAMILY SSF51556 26 283 5.41E-53 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS02215 1cd9187d8d71b9e835a2bc192816daab 328 PANTHER PTHR10060:SF18 28 287 1.6E-58 T 21-04-2016 SPH21_RS02215 1cd9187d8d71b9e835a2bc192816daab 328 Pfam PF01026 TatD related DNase 31 283 2.3E-15 T 21-04-2016 IPR001130 TatD family GO:0016788 SPH21_RS02215 1cd9187d8d71b9e835a2bc192816daab 328 PANTHER PTHR10060 28 287 1.6E-58 T 21-04-2016 IPR001130 TatD family GO:0016788 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 305 311 - T 21-04-2016 IPR018303 P-type ATPase, phosphorylation site SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 Gene3D G3DSA:3.40.50.1000 287 315 1.9E-37 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 Gene3D G3DSA:3.40.50.1000 462 577 1.9E-37 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 SUPERFAMILY SSF56784 301 321 3.77E-40 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 SUPERFAMILY SSF56784 421 579 3.77E-40 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 SUPERFAMILY SSF81653 110 205 2.22E-21 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 ProSitePatterns PS01229 Hypothetical cof family signature 2. 529 551 - T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 Hamap MF_00285 Potassium-transporting ATPase ATP-binding subunit [kdpB]. 8 693 40.02 T 21-04-2016 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 TIGRFAM TIGR01497 kdpB: K+-transporting ATPase, B subunit 3 689 0.0 T 21-04-2016 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 Gene3D G3DSA:2.70.150.10 44 206 2.2E-25 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PANTHER PTHR24093 638 693 0.0 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PANTHER PTHR24093 9 600 0.0 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 Pfam PF00122 E1-E2 ATPase 72 294 6.4E-45 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 Gene3D G3DSA:3.40.1110.10 316 461 5.5E-42 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 73 341 2.6E-33 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 376 613 4.5E-43 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 Pfam PF00702 haloacid dehalogenase-like hydrolase 299 543 7.4E-31 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 SUPERFAMILY SSF81660 314 464 4.58E-24 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 476 486 4.1E-24 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 303 317 4.1E-24 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 552 564 4.1E-24 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 152 166 4.1E-24 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 529 548 4.1E-24 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PANTHER PTHR24093:SF49 638 693 0.0 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 PANTHER PTHR24093:SF49 9 600 0.0 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 SUPERFAMILY SSF81665 632 675 7.59E-11 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 SUPERFAMILY SSF81665 206 297 7.59E-11 T 21-04-2016 SPH21_RS21065 591773ba6c7a3dbad6c566d53aab5d79 693 SUPERFAMILY SSF81665 21 104 7.59E-11 T 21-04-2016 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 PANTHER PTHR19370:SF89 10 264 7.7E-36 T 21-04-2016 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 SUPERFAMILY SSF63380 10 110 4.33E-18 T 21-04-2016 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 Pfam PF00970 Oxidoreductase FAD-binding domain 12 106 2.2E-10 T 21-04-2016 IPR008333 Oxidoreductase, FAD-binding domain SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 SUPERFAMILY SSF54292 236 343 1.57E-20 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 Gene3D G3DSA:3.40.50.80 99 238 1.5E-22 T 21-04-2016 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 PRINTS PR00406 Cytochrome B5 reductase signature 57 64 7.7E-6 T 21-04-2016 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 PRINTS PR00406 Cytochrome B5 reductase signature 119 138 7.7E-6 T 21-04-2016 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 PRINTS PR00406 Cytochrome B5 reductase signature 212 220 7.7E-6 T 21-04-2016 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 298 306 - T 21-04-2016 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 Gene3D G3DSA:2.40.30.10 10 98 3.3E-19 T 21-04-2016 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 Pfam PF00175 Oxidoreductase NAD-binding domain 120 225 3.4E-9 T 21-04-2016 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 267 338 1.7E-10 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 SUPERFAMILY SSF52343 101 242 2.88E-19 T 21-04-2016 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 PANTHER PTHR19370 10 264 7.7E-36 T 21-04-2016 SPH21_RS20445 89089326128237f2c86aa7e8f8ce9207 349 Gene3D G3DSA:3.10.20.30 239 342 3.9E-21 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS05175 c71baaf71c36e476221d82df2a252e4a 210 Gene3D G3DSA:1.20.1540.10 10 195 1.0E-31 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS05175 c71baaf71c36e476221d82df2a252e4a 210 Pfam PF01694 Rhomboid family 46 195 1.6E-26 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS05175 c71baaf71c36e476221d82df2a252e4a 210 PANTHER PTHR22936 13 195 7.0E-20 T 21-04-2016 IPR002610 Peptidase S54, rhomboid GO:0004252|GO:0006508|GO:0016021 SPH21_RS05175 c71baaf71c36e476221d82df2a252e4a 210 SUPERFAMILY SSF144091 11 195 7.32E-30 T 21-04-2016 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 PANTHER PTHR26402:SF524 3 235 5.4E-23 T 21-04-2016 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 SMART SM00850 140 232 1.7E-17 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 Gene3D G3DSA:3.40.50.2300 2 120 4.9E-26 T 21-04-2016 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 Pfam PF00072 Response regulator receiver domain 6 111 9.4E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 SUPERFAMILY SSF52172 4 122 1.71E-27 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 SMART SM00448 3 111 5.5E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 Pfam PF04397 LytTr DNA-binding domain 141 206 1.2E-11 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 PANTHER PTHR26402 3 235 5.4E-23 T 21-04-2016 SPH21_RS20915 54698728b7161e7ace9d894d3a849664 235 Gene3D G3DSA:2.40.50.40 133 199 4.1E-19 T 21-04-2016 SPH21_RS05810 dab999736201e3d3ecccad52db1eda0a 435 PIRSF PIRSF006446 1 434 1.4E-133 T 21-04-2016 IPR002585 Cytochrome ubiquinol oxidase subunit 1 GO:0016020 SPH21_RS05810 dab999736201e3d3ecccad52db1eda0a 435 PANTHER PTHR30365 1 427 7.0E-121 T 21-04-2016 SPH21_RS05810 dab999736201e3d3ecccad52db1eda0a 435 Pfam PF01654 Cytochrome bd terminal oxidase subunit I 7 427 1.4E-138 T 21-04-2016 IPR002585 Cytochrome ubiquinol oxidase subunit 1 GO:0016020 SPH21_RS05810 dab999736201e3d3ecccad52db1eda0a 435 PANTHER PTHR30365:SF0 1 427 7.0E-121 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 Pfam PF07715 TonB-dependent Receptor Plug Domain 215 324 1.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 Gene3D G3DSA:2.170.130.10 211 323 6.6E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 Gene3D G3DSA:2.60.40.1120 126 210 4.9E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 PANTHER PTHR11532 83 460 2.2E-284 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 PANTHER PTHR11532 658 1109 2.2E-284 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 PANTHER PTHR11532 547 639 2.2E-284 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 300 330 1.6E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 PANTHER PTHR11532:SF57 83 460 2.2E-284 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 PANTHER PTHR11532:SF57 658 1109 2.2E-284 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 PANTHER PTHR11532:SF57 547 639 2.2E-284 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 Gene3D G3DSA:2.40.170.20 324 344 7.2E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 Gene3D G3DSA:2.40.170.20 957 1111 7.2E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 Gene3D G3DSA:2.40.170.20 415 887 7.2E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 SUPERFAMILY SSF49464 125 205 4.32E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 Pfam PF13715 CarboxypepD_reg-like domain 127 207 2.1E-19 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 SUPERFAMILY SSF56935 948 992 2.86E-103 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 SUPERFAMILY SSF56935 1027 1111 2.86E-103 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 SUPERFAMILY SSF56935 526 876 2.86E-103 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 SUPERFAMILY SSF56935 203 348 2.86E-103 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 SUPERFAMILY SSF56935 406 494 2.86E-103 T 21-04-2016 SPH21_RS09290 2323f377af7c2415f13ce69c9b5ebfec 1111 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 125 1111 1.6E-287 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 Hamap MF_01215 Orotidine 5'-phosphate decarboxylase [pyrF]. 1 269 31.366 T 21-04-2016 IPR011995 Orotidine 5'-phosphate decarboxylase, type 2 GO:0004590|GO:0006221 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 SUPERFAMILY SSF51366 2 262 2.45E-75 T 21-04-2016 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 TIGRFAM TIGR02127 pyrF_sub2: orotidine 5'-phosphate decarboxylase 4 256 3.2E-69 T 21-04-2016 IPR011995 Orotidine 5'-phosphate decarboxylase, type 2 GO:0004590|GO:0006221 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 Gene3D G3DSA:3.20.20.70 4 262 1.6E-63 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 PANTHER PTHR19278 5 227 2.8E-69 T 21-04-2016 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 Pfam PF00215 Orotidine 5'-phosphate decarboxylase / HUMPS family 17 255 6.4E-25 T 21-04-2016 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 PANTHER PTHR19278:SF1 5 227 2.8E-69 T 21-04-2016 SPH21_RS19940 1c40c87bf99a9e8300e465709fb157a1 278 SMART SM00934 16 256 1.3E-40 T 21-04-2016 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS23620 ead1c00bf83e268664d5ac1023e4d25d 232 Pfam PF00881 Nitroreductase family 9 184 1.3E-19 T 21-04-2016 IPR029479 Nitroreductase SPH21_RS23620 ead1c00bf83e268664d5ac1023e4d25d 232 PANTHER PTHR23026 1 215 3.2E-26 T 21-04-2016 SPH21_RS23620 ead1c00bf83e268664d5ac1023e4d25d 232 Gene3D G3DSA:3.40.109.10 1 208 7.6E-51 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS23620 ead1c00bf83e268664d5ac1023e4d25d 232 PANTHER PTHR23026:SF101 1 215 3.2E-26 T 21-04-2016 SPH21_RS23620 ead1c00bf83e268664d5ac1023e4d25d 232 SUPERFAMILY SSF55469 1 206 1.2E-43 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS17660 2447f7bf3b03613ccba5d9477bd60b59 288 Gene3D G3DSA:3.30.470.10 5 120 2.4E-22 T 21-04-2016 SPH21_RS17660 2447f7bf3b03613ccba5d9477bd60b59 288 Gene3D G3DSA:3.20.10.10 145 262 6.8E-36 T 21-04-2016 SPH21_RS17660 2447f7bf3b03613ccba5d9477bd60b59 288 Pfam PF01063 Amino-transferase class IV 32 254 3.7E-49 T 21-04-2016 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: REACT_13 SPH21_RS17660 2447f7bf3b03613ccba5d9477bd60b59 288 PANTHER PTHR11825 9 257 7.5E-42 T 21-04-2016 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: REACT_13 SPH21_RS17660 2447f7bf3b03613ccba5d9477bd60b59 288 SUPERFAMILY SSF56752 4 279 3.14E-56 T 21-04-2016 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: REACT_13 SPH21_RS17660 2447f7bf3b03613ccba5d9477bd60b59 288 PANTHER PTHR11825:SF55 9 257 7.5E-42 T 21-04-2016 SPH21_RS08985 86267b2bd0ea24425078ba0ca33031e0 370 Gene3D G3DSA:3.40.50.2000 205 365 3.0E-12 T 21-04-2016 SPH21_RS08985 86267b2bd0ea24425078ba0ca33031e0 370 Gene3D G3DSA:3.40.50.2000 1 204 6.6E-25 T 21-04-2016 SPH21_RS08985 86267b2bd0ea24425078ba0ca33031e0 370 TIGRFAM TIGR03568 NeuC_NnaA: UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing 2 362 1.0E-108 T 21-04-2016 IPR020004 UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing GO:0004553|GO:0006047 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS08985 86267b2bd0ea24425078ba0ca33031e0 370 SUPERFAMILY SSF53756 1 366 1.18E-61 T 21-04-2016 SPH21_RS08985 86267b2bd0ea24425078ba0ca33031e0 370 Pfam PF02350 UDP-N-acetylglucosamine 2-epimerase 22 363 6.9E-67 T 21-04-2016 IPR003331 UDP-N-acetylglucosamine 2-epimerase domain SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 PANTHER PTHR11731:SF140 291 626 4.4E-78 T 21-04-2016 SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 PANTHER PTHR11731:SF140 43 125 4.4E-78 T 21-04-2016 SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 SUPERFAMILY SSF53474 370 626 3.72E-65 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 SUPERFAMILY SSF82171 40 364 5.76E-15 T 21-04-2016 SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 Gene3D G3DSA:2.120.10.30 35 280 1.6E-18 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 Pfam PF00326 Prolyl oligopeptidase family 414 626 9.1E-43 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 PANTHER PTHR11731 291 626 4.4E-78 T 21-04-2016 SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 PANTHER PTHR11731 43 125 4.4E-78 T 21-04-2016 SPH21_RS07760 3d40f87d63c36d8df9b35e40e3ed5d51 628 Gene3D G3DSA:3.40.50.1820 370 626 7.6E-65 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16670 81133b3945edb6fffbfae44586f0da69 215 Gene3D G3DSA:3.40.30.10 5 210 1.8E-41 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS16670 81133b3945edb6fffbfae44586f0da69 215 Pfam PF02630 SCO1/SenC 51 187 6.0E-17 T 21-04-2016 IPR003782 Copper chaperone SCO1/SenC SPH21_RS16670 81133b3945edb6fffbfae44586f0da69 215 PANTHER PTHR12151 51 187 1.4E-22 T 21-04-2016 IPR003782 Copper chaperone SCO1/SenC SPH21_RS16670 81133b3945edb6fffbfae44586f0da69 215 PANTHER PTHR12151:SF10 51 187 1.4E-22 T 21-04-2016 SPH21_RS16670 81133b3945edb6fffbfae44586f0da69 215 SUPERFAMILY SSF52833 48 208 5.43E-34 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Gene3D G3DSA:3.20.20.70 852 1223 6.5E-183 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Gene3D G3DSA:2.160.20.60 1243 1499 2.2E-99 T 21-04-2016 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Gene3D G3DSA:3.20.20.70 456 805 5.2E-104 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 SUPERFAMILY SSF51395 454 1222 2.93E-267 T 21-04-2016 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 SUPERFAMILY SSF69336 1235 1499 1.07E-92 T 21-04-2016 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 PANTHER PTHR11938:SF1 10 1502 0.0 T 21-04-2016 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 PANTHER PTHR11938 10 1502 0.0 T 21-04-2016 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Pfam PF01493 GXGXG motif 1266 1453 2.5E-82 T 21-04-2016 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Gene3D G3DSA:3.60.20.10 21 455 8.9E-176 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Pfam PF00310 Glutamine amidotransferases class-II 21 444 1.6E-171 T 21-04-2016 IPR017932 Glutamine amidotransferase type 2 domain SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Pfam PF04898 Glutamate synthase central domain 473 757 1.2E-113 T 21-04-2016 IPR006982 Glutamate synthase, central-N GO:0006807|GO:0015930|GO:0055114 UniPathway: UPA00045 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 Pfam PF01645 Conserved region in glutamate synthase 818 1185 9.1E-158 T 21-04-2016 IPR002932 Glutamate synthase domain GO:0006537|GO:0015930|GO:0016638|GO:0055114 SPH21_RS15850 94ed9b2c077a4bbf87efa22400fb3f30 1504 SUPERFAMILY SSF56235 21 447 6.11E-147 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS23235 f17b72cd44cd3ea1e13e5cd628719707 175 Gene3D G3DSA:3.40.630.30 11 150 9.2E-14 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23235 f17b72cd44cd3ea1e13e5cd628719707 175 SUPERFAMILY SSF55729 11 150 6.42E-11 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS08320 eda031947b30ade1991258e0bb345b49 307 Gene3D G3DSA:3.40.50.720 2 255 2.6E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08320 eda031947b30ade1991258e0bb345b49 307 Pfam PF08338 Domain of unknown function (DUF1731) 253 299 2.6E-19 T 21-04-2016 IPR013549 Domain of unknown function DUF1731 SPH21_RS08320 eda031947b30ade1991258e0bb345b49 307 SUPERFAMILY SSF51735 1 302 1.3E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08320 eda031947b30ade1991258e0bb345b49 307 TIGRFAM TIGR01777 yfcH: TIGR01777 family protein 4 296 1.4E-93 T 21-04-2016 IPR010099 Epimerase family protein SDR39U1 SPH21_RS08320 eda031947b30ade1991258e0bb345b49 307 PANTHER PTHR11092:SF0 1 305 1.8E-109 T 21-04-2016 SPH21_RS08320 eda031947b30ade1991258e0bb345b49 307 Pfam PF01370 NAD dependent epimerase/dehydratase family 4 218 6.5E-19 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS08320 eda031947b30ade1991258e0bb345b49 307 PANTHER PTHR11092 1 305 1.8E-109 T 21-04-2016 IPR010099 Epimerase family protein SDR39U1 SPH21_RS20260 e41bf31e90199d428b8825975b7fbc8e 313 SMART SM00382 30 209 5.2E-5 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS20260 e41bf31e90199d428b8825975b7fbc8e 313 Gene3D G3DSA:3.40.50.300 3 224 8.0E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20260 e41bf31e90199d428b8825975b7fbc8e 313 PANTHER PTHR24220:SF0 5 224 1.5E-109 T 21-04-2016 SPH21_RS20260 e41bf31e90199d428b8825975b7fbc8e 313 Pfam PF00005 ABC transporter 22 162 5.3E-25 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS20260 e41bf31e90199d428b8825975b7fbc8e 313 SUPERFAMILY SSF52540 4 224 5.53E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20260 e41bf31e90199d428b8825975b7fbc8e 313 ProSitePatterns PS00211 ABC transporters family signature. 135 149 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS20260 e41bf31e90199d428b8825975b7fbc8e 313 PANTHER PTHR24220 5 224 1.5E-109 T 21-04-2016 SPH21_RS01395 bc5bc93795db4acb30cbefb95fad6627 408 PANTHER PTHR30097 60 182 5.6E-17 T 21-04-2016 SPH21_RS01395 bc5bc93795db4acb30cbefb95fad6627 408 PANTHER PTHR30097 229 402 5.6E-17 T 21-04-2016 SPH21_RS01395 bc5bc93795db4acb30cbefb95fad6627 408 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 76 191 7.2E-30 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS01395 bc5bc93795db4acb30cbefb95fad6627 408 Gene3D G3DSA:2.40.50.100 176 190 2.1E-5 T 21-04-2016 SPH21_RS01395 bc5bc93795db4acb30cbefb95fad6627 408 Gene3D G3DSA:2.40.50.100 90 123 2.1E-5 T 21-04-2016 SPH21_RS01395 bc5bc93795db4acb30cbefb95fad6627 408 PANTHER PTHR30097:SF3 60 182 5.6E-17 T 21-04-2016 SPH21_RS01395 bc5bc93795db4acb30cbefb95fad6627 408 PANTHER PTHR30097:SF3 229 402 5.6E-17 T 21-04-2016 SPH21_RS09715 4c249ff6d77c7e4a2ffd8075ef3d29f0 494 Gene3D G3DSA:1.25.40.10 349 436 2.4E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09715 4c249ff6d77c7e4a2ffd8075ef3d29f0 494 Gene3D G3DSA:1.25.40.10 207 316 2.4E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09715 4c249ff6d77c7e4a2ffd8075ef3d29f0 494 Pfam PF07980 SusD family 272 494 2.3E-36 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09715 4c249ff6d77c7e4a2ffd8075ef3d29f0 494 SUPERFAMILY SSF48452 31 494 6.7E-119 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09715 4c249ff6d77c7e4a2ffd8075ef3d29f0 494 Pfam PF14322 Starch-binding associating with outer membrane 93 225 2.0E-28 T 21-04-2016 SPH21_RS04255 d117267d53148f0415b3965447cdf50c 193 Gene3D G3DSA:3.40.430.10 3 189 5.9E-27 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS04255 d117267d53148f0415b3965447cdf50c 193 PANTHER PTHR38011 2 192 5.6E-45 T 21-04-2016 SPH21_RS04255 d117267d53148f0415b3965447cdf50c 193 SUPERFAMILY SSF53597 2 190 2.75E-32 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS04255 d117267d53148f0415b3965447cdf50c 193 PANTHER PTHR38011:SF2 2 192 5.6E-45 T 21-04-2016 SPH21_RS04255 d117267d53148f0415b3965447cdf50c 193 Pfam PF01872 RibD C-terminal domain 2 184 4.2E-22 T 21-04-2016 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SPH21_RS22365 34fdbfc03de9c5af5b8d4c584c93d411 210 Pfam PF13618 Gluconate 2-dehydrogenase subunit 3 65 190 2.5E-30 T 21-04-2016 IPR027056 Gluconate 2-dehydrogenase subunit 3 KEGG: 00030+1.1.99.3|MetaCyc: PWY-7165 SPH21_RS08920 448350cce28658233d3a7098ec3a0a6b 196 Gene3D G3DSA:2.160.10.10 25 147 7.1E-35 T 21-04-2016 SPH21_RS08920 448350cce28658233d3a7098ec3a0a6b 196 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 95 123 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS08920 448350cce28658233d3a7098ec3a0a6b 196 PANTHER PTHR23416 27 147 1.4E-27 T 21-04-2016 SPH21_RS08920 448350cce28658233d3a7098ec3a0a6b 196 SUPERFAMILY SSF51161 26 149 1.94E-33 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS08920 448350cce28658233d3a7098ec3a0a6b 196 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 87 121 2.5E-7 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 PANTHER PTHR30231 3 164 3.4E-41 T 21-04-2016 SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 Pfam PF00929 Exonuclease 5 157 1.2E-27 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 Pfam PF01541 GIY-YIG catalytic domain 199 239 7.0E-8 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 TIGRFAM TIGR00573 dnaq: exonuclease, DNA polymerase III, epsilon subunit family 5 170 1.1E-23 T 21-04-2016 IPR006054 DNA polymerase III, epsilon subunit GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 SMART SM00479 2 167 6.6E-41 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 SUPERFAMILY SSF53098 2 170 5.32E-51 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 PANTHER PTHR30231:SF8 3 164 3.4E-41 T 21-04-2016 SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 Gene3D G3DSA:3.30.420.10 1 165 3.1E-49 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 SUPERFAMILY SSF82771 197 277 3.01E-16 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 SMART SM00465 197 278 1.6E-8 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS17090 4084f9d8cdb93e2a7c50b49f1a1bb1b6 463 Gene3D G3DSA:3.40.1440.10 198 239 6.8E-7 T 21-04-2016 IPR027299 GIY-YIG domain SPH21_RS05635 baefc943b7f53334c6ab4c31ceae1403 171 Gene3D G3DSA:3.40.50.2020 6 148 9.2E-27 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS05635 baefc943b7f53334c6ab4c31ceae1403 171 PANTHER PTHR11608 2 159 6.4E-25 T 21-04-2016 SPH21_RS05635 baefc943b7f53334c6ab4c31ceae1403 171 SUPERFAMILY SSF53271 8 162 4.04E-24 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS05635 baefc943b7f53334c6ab4c31ceae1403 171 Pfam PF00156 Phosphoribosyl transferase domain 9 153 3.6E-20 T 21-04-2016 IPR000836 Phosphoribosyltransferase domain GO:0009116 SPH21_RS13555 9ab420cf4a525c3116d33a1b48744022 190 Pfam PF10030 Uncharacterized protein conserved in bacteria (DUF2272) 48 177 3.7E-16 T 21-04-2016 IPR019262 Domain of unknown function DUF2272 SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 PANTHER PTHR22778 2 300 3.5E-97 T 21-04-2016 SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 Pfam PF00581 Rhodanese-like domain 117 210 5.1E-14 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 SUPERFAMILY SSF52821 105 238 1.06E-32 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 Pfam PF12368 Rhodanase C-terminal 220 286 4.1E-16 T 21-04-2016 IPR022111 Rhodanase, C-terminal SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 Hamap MF_00469 UPF0176 protein YceA [yceA]. 2 255 36.937 T 21-04-2016 IPR020936 Uncharacterised protein family UPF0176 SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 Gene3D G3DSA:3.40.250.10 104 226 4.4E-33 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 PANTHER PTHR22778:SF21 2 300 3.5E-97 T 21-04-2016 SPH21_RS06975 b08c424424e2c2475ecf084d53c2a6bb 321 SMART SM00450 116 216 1.5E-20 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 Gene3D G3DSA:3.30.360.10 177 407 2.7E-26 T 21-04-2016 SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 5 27 6.8E-4 T 21-04-2016 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 Gene3D G3DSA:3.40.50.720 36 176 6.4E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 SUPERFAMILY SSF55347 171 197 1.0E-21 T 21-04-2016 SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 SUPERFAMILY SSF55347 236 369 1.0E-21 T 21-04-2016 SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 SUPERFAMILY SSF51735 32 194 2.63E-45 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 PANTHER PTHR22604:SF122 1 197 2.7E-119 T 21-04-2016 SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 PANTHER PTHR22604:SF122 213 416 2.7E-119 T 21-04-2016 SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 PANTHER PTHR22604 1 197 2.7E-119 T 21-04-2016 SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 PANTHER PTHR22604 213 416 2.7E-119 T 21-04-2016 SPH21_RS03905 a883b522633c14c61bc9182859fc5ff9 435 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 40 162 1.1E-17 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 Pfam PF13793 N-terminal domain of ribose phosphate pyrophosphokinase 9 123 3.9E-42 T 21-04-2016 IPR029099 Ribose-phosphate pyrophosphokinase, N-terminal domain KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|UniPathway: UPA00087 SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 SMART SM01400 8 123 5.2E-68 T 21-04-2016 SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 PANTHER PTHR10210:SF41 1 317 2.7E-153 T 21-04-2016 SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 Gene3D G3DSA:3.40.50.2020 5 161 6.2E-65 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 SUPERFAMILY SSF53271 72 302 1.33E-55 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 PANTHER PTHR10210 1 317 2.7E-153 T 21-04-2016 SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 Pfam PF14572 Phosphoribosyl synthetase-associated domain 200 312 5.4E-21 T 21-04-2016 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|UniPathway: UPA00087 SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 Gene3D G3DSA:3.40.50.2020 162 286 1.9E-42 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 TIGRFAM TIGR01251 ribP_PPkin: ribose-phosphate diphosphokinase 9 312 1.0E-104 T 21-04-2016 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|UniPathway: UPA00087 SPH21_RS25375 c322f19a37cea279a028b5f76bacef02 318 ProSitePatterns PS00114 Phosphoribosyl pyrophosphate synthase signature. 131 146 - T 21-04-2016 IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site GO:0000287|GO:0004749|GO:0009156|GO:0044249 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|Reactome: REACT_474|UniPathway: UPA00087 SPH21_RS04780 c1922d153bfdb6900983d341ebfd8099 222 Gene3D G3DSA:3.40.50.360 1 218 2.2E-66 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS04780 c1922d153bfdb6900983d341ebfd8099 222 SUPERFAMILY SSF52218 1 216 9.01E-65 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS04780 c1922d153bfdb6900983d341ebfd8099 222 Pfam PF02525 Flavodoxin-like fold 1 206 4.3E-52 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS04780 c1922d153bfdb6900983d341ebfd8099 222 PANTHER PTHR10204:SF46 1 211 6.1E-70 T 21-04-2016 SPH21_RS04780 c1922d153bfdb6900983d341ebfd8099 222 PANTHER PTHR10204 1 211 6.1E-70 T 21-04-2016 SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 PRINTS PR00344 Bacterial sensor protein C-terminal signature 237 250 6.7E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 PRINTS PR00344 Bacterial sensor protein C-terminal signature 179 193 6.7E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 PRINTS PR00344 Bacterial sensor protein C-terminal signature 213 231 6.7E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 148 249 4.9E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 Gene3D G3DSA:3.30.565.10 103 249 4.2E-26 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 SUPERFAMILY SSF55874 100 249 1.14E-25 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 SMART SM00387 141 253 3.8E-11 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10165 a68e43dbc0e5681cf2a6e3c68293aabb 254 PANTHER PTHR24423 8 249 1.3E-22 T 21-04-2016 SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 SUPERFAMILY SSF53474 475 725 2.13E-84 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 Gene3D G3DSA:3.40.50.1820 475 725 1.6E-96 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 SUPERFAMILY SSF82171 20 469 7.32E-67 T 21-04-2016 SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 PANTHER PTHR11731:SF110 64 725 5.7E-243 T 21-04-2016 SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 PANTHER PTHR11731 64 725 5.7E-243 T 21-04-2016 SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 Pfam PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region 100 440 1.9E-107 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 Pfam PF00326 Prolyl oligopeptidase family 530 725 4.5E-59 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS12240 ab2c51fd8d3bd4b63fdd91ff9f9950fd 725 Gene3D G3DSA:2.140.10.30 21 469 1.3E-123 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 ProSitePatterns PS01273 Coenzyme A transferases signature 1. 18 33 - T 21-04-2016 IPR004163 Coenzyme A transferase binding site GO:0008152|GO:0008410 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 SMART SM00882 6 217 3.2E-86 T 21-04-2016 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 PANTHER PTHR13707:SF23 1 231 1.4E-132 T 21-04-2016 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 TIGRFAM TIGR02429 pcaI_scoA_fam: 3-oxoacid CoA-transferase, A subunit 1 216 1.8E-81 T 21-04-2016 IPR012792 3-oxoacid CoA-transferase, subunit A GO:0008410 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 Pfam PF01144 Coenzyme A transferase 7 215 1.0E-74 T 21-04-2016 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 Gene3D G3DSA:3.40.1080.10 3 216 1.7E-98 T 21-04-2016 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 PANTHER PTHR13707 1 231 1.4E-132 T 21-04-2016 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SPH21_RS23020 32fb60e791c20264a7d10850c85ad6e6 231 SUPERFAMILY SSF100950 2 228 1.2E-87 T 21-04-2016 SPH21_RS17575 a45a8c9b2c9145bc7990e0fae6ef214b 228 PANTHER PTHR42208:SF1 1 225 5.5E-19 T 21-04-2016 SPH21_RS17575 a45a8c9b2c9145bc7990e0fae6ef214b 228 PANTHER PTHR42208 1 225 5.5E-19 T 21-04-2016 SPH21_RS17575 a45a8c9b2c9145bc7990e0fae6ef214b 228 Pfam PF13386 Cytochrome C biogenesis protein transmembrane region 4 201 7.9E-46 T 21-04-2016 SPH21_RS02685 27c6b5123aa30a1765199ad8321af4ee 300 PANTHER PTHR31136:SF2 1 297 1.4E-124 T 21-04-2016 SPH21_RS02685 27c6b5123aa30a1765199ad8321af4ee 300 Pfam PF07063 Domain of unknown function (DUF1338) 6 293 1.8E-81 T 21-04-2016 IPR009770 Domain of unknown function DUF1338 SPH21_RS02685 27c6b5123aa30a1765199ad8321af4ee 300 SMART SM01150 7 293 1.0E-107 T 21-04-2016 IPR009770 Domain of unknown function DUF1338 SPH21_RS02685 27c6b5123aa30a1765199ad8321af4ee 300 PANTHER PTHR31136 1 297 1.4E-124 T 21-04-2016 SPH21_RS02630 407521e73c6566824a9376438ef12a70 282 Pfam PF06977 SdiA-regulated 206 266 1.2E-4 T 21-04-2016 IPR009722 SdiA-regulated SPH21_RS02630 407521e73c6566824a9376438ef12a70 282 Gene3D G3DSA:2.120.10.30 166 266 5.0E-7 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02630 407521e73c6566824a9376438ef12a70 282 Gene3D G3DSA:2.120.10.30 45 107 5.0E-7 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02630 407521e73c6566824a9376438ef12a70 282 SUPERFAMILY SSF101898 41 267 1.7E-8 T 21-04-2016 SPH21_RS03625 e5ef677b1d1091dd4cb0babe0e774b73 192 Pfam PF04011 LemA family 11 192 1.2E-69 T 21-04-2016 IPR007156 LemA SPH21_RS03625 e5ef677b1d1091dd4cb0babe0e774b73 192 PANTHER PTHR34478:SF2 1 192 1.8E-76 T 21-04-2016 SPH21_RS03625 e5ef677b1d1091dd4cb0babe0e774b73 192 Gene3D G3DSA:1.20.1440.20 17 192 1.3E-65 T 21-04-2016 IPR023353 LemA-like domain SPH21_RS03625 e5ef677b1d1091dd4cb0babe0e774b73 192 PANTHER PTHR34478 1 192 1.8E-76 T 21-04-2016 SPH21_RS03625 e5ef677b1d1091dd4cb0babe0e774b73 192 SUPERFAMILY SSF140478 25 179 2.09E-53 T 21-04-2016 IPR023353 LemA-like domain SPH21_RS06420 56740135639547875469c21c8ac7f944 311 Pfam PF02517 CAAX protease self-immunity 174 260 2.4E-16 T 21-04-2016 IPR003675 CAAX amino terminal protease GO:0016020 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 TIGRFAM TIGR02034 CysN: sulfate adenylyltransferase, large subunit 4 410 1.9E-170 T 21-04-2016 IPR011779 Sulphate adenylyltransferase, large subunit GO:0006790 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932|UniPathway: UPA00140 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 57 72 - T 21-04-2016 IPR031157 Tr-type G domain, conserved site SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 PANTHER PTHR23115 8 308 8.6E-69 T 21-04-2016 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 Pfam PF00009 Elongation factor Tu GTP binding domain 2 187 8.6E-44 T 21-04-2016 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 SUPERFAMILY SSF50465 311 408 6.71E-26 T 21-04-2016 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 SUPERFAMILY SSF50447 219 307 7.07E-22 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 PRINTS PR00315 GTP-binding elongation factor signature 137 146 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 PRINTS PR00315 GTP-binding elongation factor signature 84 94 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 PRINTS PR00315 GTP-binding elongation factor signature 64 72 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 PRINTS PR00315 GTP-binding elongation factor signature 100 111 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 PRINTS PR00315 GTP-binding elongation factor signature 5 18 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 Gene3D G3DSA:3.40.50.300 2 208 3.0E-66 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 Gene3D G3DSA:2.40.30.10 219 329 3.9E-22 T 21-04-2016 SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 SUPERFAMILY SSF52540 3 209 2.08E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15915 c7616ecf11b5e1d3381daad280b55cf7 417 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 8 187 1.6E-13 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 Pfam PF12833 Helix-turn-helix domain 176 254 2.2E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 Pfam PF02311 AraC-like ligand binding domain 21 82 1.2E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 SMART SM00342 170 253 1.2E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 PANTHER PTHR11019 20 261 4.2E-41 T 21-04-2016 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 237 253 4.5E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 222 237 4.5E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 SUPERFAMILY SSF51215 8 131 1.14E-10 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 PANTHER PTHR11019:SF45 20 261 4.2E-41 T 21-04-2016 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 SUPERFAMILY SSF46689 207 257 2.42E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 Gene3D G3DSA:1.10.10.60 206 256 4.7E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06215 2d040513c1bb9932f0da4c3c36d1cea8 263 Gene3D G3DSA:2.60.120.280 18 88 1.0E-8 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS13890 98587dd4d1588fc2e41e48354c94832e 154 SUPERFAMILY SSF55961 7 136 9.26E-23 T 21-04-2016 SPH21_RS13890 98587dd4d1588fc2e41e48354c94832e 154 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 17 135 2.2E-14 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS13890 98587dd4d1588fc2e41e48354c94832e 154 Gene3D G3DSA:3.30.530.20 2 136 6.6E-21 T 21-04-2016 IPR023393 START-like domain SPH21_RS08995 22a4ae26550a9dfa99610595c9844c13 226 SUPERFAMILY SSF53448 2 223 1.78E-53 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08995 22a4ae26550a9dfa99610595c9844c13 226 Gene3D G3DSA:3.90.550.10 2 223 5.7E-66 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08995 22a4ae26550a9dfa99610595c9844c13 226 Pfam PF02348 Cytidylyltransferase 3 218 2.7E-29 T 21-04-2016 IPR003329 Acylneuraminate cytidylyltransferase KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|UniPathway: UPA00030|UniPathway: UPA00358 SPH21_RS08995 22a4ae26550a9dfa99610595c9844c13 226 PANTHER PTHR21485 1 210 5.2E-53 T 21-04-2016 SPH21_RS23920 d7c238a0c61d6621eb9eb1a75e080901 186 Pfam PF03352 Methyladenine glycosylase 16 123 2.3E-38 T 21-04-2016 IPR005019 Methyladenine glycosylase GO:0006284|GO:0008725 SPH21_RS23920 d7c238a0c61d6621eb9eb1a75e080901 186 PANTHER PTHR30037:SF4 14 184 1.5E-65 T 21-04-2016 SPH21_RS23920 d7c238a0c61d6621eb9eb1a75e080901 186 PANTHER PTHR30037 14 184 1.5E-65 T 21-04-2016 SPH21_RS23920 d7c238a0c61d6621eb9eb1a75e080901 186 SUPERFAMILY SSF48150 15 173 1.57E-47 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS23920 d7c238a0c61d6621eb9eb1a75e080901 186 Gene3D G3DSA:1.10.340.30 15 170 3.8E-46 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 Pfam PF01252 Signal peptidase (SPase) II 40 180 1.3E-26 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 78 86 2.1E-12 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 127 142 2.1E-12 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 163 179 2.1E-12 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 TIGRFAM TIGR00077 lspA: signal peptidase II 27 187 1.8E-26 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 PANTHER PTHR33695 11 196 1.3E-30 T 21-04-2016 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 Hamap MF_00161 Lipoprotein signal peptidase [lspA]. 31 188 13.65 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS11670 b08837ca6c15fbdc3d1c47c6e2dda621 202 PANTHER PTHR33695:SF1 11 196 1.3E-30 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Gene3D G3DSA:2.40.50.250 481 573 2.5E-40 T 21-04-2016 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Gene3D G3DSA:3.30.70.870 302 397 7.2E-35 T 21-04-2016 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Gene3D G3DSA:3.30.70.240 398 477 4.5E-27 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Gene3D G3DSA:2.40.30.10 200 301 6.2E-28 T 21-04-2016 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 PRINTS PR00315 GTP-binding elongation factor signature 6 19 3.8E-15 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 PRINTS PR00315 GTP-binding elongation factor signature 86 97 3.8E-15 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 PRINTS PR00315 GTP-binding elongation factor signature 70 80 3.8E-15 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 PRINTS PR00315 GTP-binding elongation factor signature 50 58 3.8E-15 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 PRINTS PR00315 GTP-binding elongation factor signature 122 131 3.8E-15 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 TIGRFAM TIGR01394 TypA_BipA: GTP-binding protein TypA/BipA 4 594 8.3E-272 T 21-04-2016 IPR006298 GTP-binding protein TypA GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Gene3D G3DSA:3.40.50.300 2 198 1.8E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 3 145 2.9E-24 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 SUPERFAMILY SSF50447 150 297 1.79E-32 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Pfam PF00009 Elongation factor Tu GTP binding domain 3 194 1.3E-55 T 21-04-2016 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 SUPERFAMILY SSF52540 2 199 1.77E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Pfam PF03144 Elongation factor Tu domain 2 217 286 2.2E-10 T 21-04-2016 IPR004161 Translation elongation factor EFTu/EF1A, domain 2 GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 Pfam PF00679 Elongation factor G C-terminus 394 476 3.8E-20 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 PANTHER PTHR23115:SF14 2 589 1.6E-257 T 21-04-2016 IPR006298 GTP-binding protein TypA GO:0005525 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 SUPERFAMILY SSF54980 396 509 7.67E-25 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 SMART SM00838 393 484 0.0033 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 43 58 - T 21-04-2016 IPR031157 Tr-type G domain, conserved site SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 PANTHER PTHR23115 2 589 1.6E-257 T 21-04-2016 SPH21_RS08070 392e0015b917670cbbc902e5b3a32bde 601 SUPERFAMILY SSF54980 300 385 7.19E-15 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 PANTHER PTHR10953 1 159 6.4E-75 T 21-04-2016 SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 PANTHER PTHR10953 185 238 6.4E-75 T 21-04-2016 SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 Pfam PF00899 ThiF family 10 178 1.0E-29 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 Gene3D G3DSA:3.40.50.720 216 236 3.0E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 Gene3D G3DSA:3.40.50.720 4 184 3.0E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 SUPERFAMILY SSF69572 3 237 5.89E-54 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 PANTHER PTHR10953:SF145 1 159 6.4E-75 T 21-04-2016 SPH21_RS18225 91e5f8cbf3305dbfed6552155ef0725c 239 PANTHER PTHR10953:SF145 185 238 6.4E-75 T 21-04-2016 SPH21_RS19930 219734a3ee68f356eb52295a43b5782a 256 Pfam PF00005 ABC transporter 17 172 1.2E-22 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS19930 219734a3ee68f356eb52295a43b5782a 256 TIGRFAM TIGR01978 sufC: FeS assembly ATPase SufC 2 244 3.1E-112 T 21-04-2016 IPR010230 FeS cluster assembly SUF system, ATPase SufC GO:0005524|GO:0006810 SPH21_RS19930 219734a3ee68f356eb52295a43b5782a 256 SUPERFAMILY SSF52540 2 231 1.33E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19930 219734a3ee68f356eb52295a43b5782a 256 SMART SM00382 26 223 3.3E-8 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS19930 219734a3ee68f356eb52295a43b5782a 256 PANTHER PTHR24220:SF85 3 253 4.3E-131 T 21-04-2016 SPH21_RS19930 219734a3ee68f356eb52295a43b5782a 256 PANTHER PTHR24220 3 253 4.3E-131 T 21-04-2016 SPH21_RS19930 219734a3ee68f356eb52295a43b5782a 256 Gene3D G3DSA:3.40.50.300 1 237 6.4E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 SUPERFAMILY SSF51445 35 399 6.38E-77 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 PANTHER PTHR36447 33 696 3.4E-173 T 21-04-2016 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 Gene3D G3DSA:2.60.40.1180 647 696 1.6E-13 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 ProSitePatterns PS00659 Glycosyl hydrolases family 5 signature. 169 178 - T 21-04-2016 IPR018087 Glycoside hydrolase, family 5, conserved site GO:0004553|GO:0005975 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 Pfam PF02449 Beta-galactosidase 41 419 5.0E-101 T 21-04-2016 IPR013529 Glycoside hydrolase, family 42, N-terminal GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 Gene3D G3DSA:3.20.20.80 37 421 5.0E-96 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 Pfam PF08532 Beta-galactosidase trimerisation domain 437 639 2.3E-49 T 21-04-2016 IPR013738 Beta-galactosidase trimerisation GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 PIRSF PIRSF001084 29 696 3.4E-141 T 21-04-2016 IPR003476 Glycoside hydrolase, family 42 GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 Pfam PF08533 Beta-galactosidase C-terminal domain 656 695 1.8E-4 T 21-04-2016 IPR013739 Beta-galactosidase C-terminal GO:0004565|GO:0006012 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 PANTHER PTHR36447:SF1 33 696 3.4E-173 T 21-04-2016 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 SUPERFAMILY SSF51011 644 696 8.63E-10 T 21-04-2016 SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 SUPERFAMILY SSF52317 436 640 1.28E-37 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS13120 1b0727c40389b48631ed3a10e0d60922 696 Gene3D G3DSA:3.40.50.880 437 643 3.0E-47 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS15250 a32428582e33f9330a8716e0ed639b20 231 SUPERFAMILY SSF53335 57 221 3.04E-21 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS15250 a32428582e33f9330a8716e0ed639b20 231 Gene3D G3DSA:3.40.50.150 57 222 1.1E-19 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS15250 a32428582e33f9330a8716e0ed639b20 231 Pfam PF08241 Methyltransferase domain 62 154 6.9E-11 T 21-04-2016 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SPH21_RS13690 bd7b680d7215754e39d9db4b8b2ded3c 247 SUPERFAMILY SSF82153 203 226 1.83E-8 T 21-04-2016 IPR000782 FAS1 domain SPH21_RS13690 bd7b680d7215754e39d9db4b8b2ded3c 247 SUPERFAMILY SSF82153 43 164 1.83E-8 T 21-04-2016 IPR000782 FAS1 domain SPH21_RS13690 bd7b680d7215754e39d9db4b8b2ded3c 247 Gene3D G3DSA:2.30.180.10 43 139 7.5E-7 T 21-04-2016 IPR000782 FAS1 domain SPH21_RS13690 bd7b680d7215754e39d9db4b8b2ded3c 247 Gene3D G3DSA:2.30.180.10 175 225 7.5E-7 T 21-04-2016 IPR000782 FAS1 domain SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PRINTS PR00412 Epoxide hydrolase signature 252 274 4.18E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PRINTS PR00412 Epoxide hydrolase signature 93 106 4.18E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PRINTS PR00412 Epoxide hydrolase signature 107 120 4.18E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PRINTS PR00412 Epoxide hydrolase signature 32 50 4.18E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PRINTS PR00111 Alpha/beta hydrolase fold signature 50 65 1.78E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PRINTS PR00111 Alpha/beta hydrolase fold signature 93 106 1.78E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PRINTS PR00111 Alpha/beta hydrolase fold signature 107 120 1.78E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 Pfam PF00561 alpha/beta hydrolase fold 26 136 1.3E-17 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PANTHER PTHR10992:SF877 1 277 3.9E-44 T 21-04-2016 SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 Gene3D G3DSA:3.40.50.1820 3 275 1.9E-55 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 SUPERFAMILY SSF53474 3 276 4.7E-55 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22790 eb818d936cf4c17d916b621d12d992b7 277 PANTHER PTHR10992 1 277 3.9E-44 T 21-04-2016 SPH21_RS26495 2697ec92654175520a01ad043d06bedc 167 PANTHER PTHR26402 46 159 3.3E-18 T 21-04-2016 SPH21_RS26495 2697ec92654175520a01ad043d06bedc 167 PANTHER PTHR26402:SF596 46 159 3.3E-18 T 21-04-2016 SPH21_RS26495 2697ec92654175520a01ad043d06bedc 167 SUPERFAMILY SSF52172 42 159 2.85E-23 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS26495 2697ec92654175520a01ad043d06bedc 167 Pfam PF00072 Response regulator receiver domain 48 153 1.3E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS26495 2697ec92654175520a01ad043d06bedc 167 Gene3D G3DSA:3.40.50.2300 44 160 2.6E-22 T 21-04-2016 SPH21_RS26495 2697ec92654175520a01ad043d06bedc 167 SMART SM00448 46 156 2.3E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PANTHER PTHR11406 2 396 4.3E-219 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 Gene3D G3DSA:3.40.50.1260 1 178 2.6E-72 T 21-04-2016 IPR015824 Phosphoglycerate kinase, N-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 349 360 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 168 190 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 108 123 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 313 338 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 191 210 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 136 158 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 8 24 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 30 52 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PRINTS PR00477 Phosphoglycerate kinase family signature 372 389 3.2E-90 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 Gene3D G3DSA:3.40.50.1270 180 384 1.3E-84 T 21-04-2016 IPR015901 Phosphoglycerate kinase, C-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 Pfam PF00162 Phosphoglycerate kinase 4 386 1.1E-159 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 PIRSF PIRSF000724 1 396 2.7E-155 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 Hamap MF_00145 Phosphoglycerate kinase [pgk]. 3 396 40.631 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS00325 efe1597bcff0c389942ae9f801cb8e31 396 SUPERFAMILY SSF53748 1 396 3.18E-153 T 21-04-2016 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|UniPathway: UPA00109 SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 ProSitePatterns PS00194 Thioredoxin family active site. 257 275 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 SUPERFAMILY SSF52833 33 221 3.15E-39 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 Pfam PF08534 Redoxin 253 360 4.3E-9 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 Gene3D G3DSA:3.40.30.10 249 373 2.5E-22 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 Gene3D G3DSA:3.40.30.10 36 205 1.3E-29 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 PANTHER PTHR10681 121 296 7.9E-37 T 21-04-2016 SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 PANTHER PTHR10681 32 100 7.9E-37 T 21-04-2016 SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 SUPERFAMILY SSF52833 240 372 5.63E-18 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 PANTHER PTHR10681:SF91 121 296 7.9E-37 T 21-04-2016 SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 PANTHER PTHR10681:SF91 32 100 7.9E-37 T 21-04-2016 SPH21_RS02665 15c882029e99abeaaacc1fb9f6e47746 377 Pfam PF00578 AhpC/TSA family 36 171 1.1E-19 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS03295 007b54166700c3ad3eadd1916d23b774 231 Pfam PF07722 Peptidase C26 18 209 1.1E-44 T 21-04-2016 IPR011697 Peptidase C26 GO:0006541|GO:0016787 SPH21_RS03295 007b54166700c3ad3eadd1916d23b774 231 PANTHER PTHR11922 44 57 2.6E-38 T 21-04-2016 SPH21_RS03295 007b54166700c3ad3eadd1916d23b774 231 PANTHER PTHR11922 75 231 2.6E-38 T 21-04-2016 SPH21_RS03295 007b54166700c3ad3eadd1916d23b774 231 Gene3D G3DSA:3.40.50.880 17 218 9.8E-38 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS03295 007b54166700c3ad3eadd1916d23b774 231 PANTHER PTHR11922:SF18 44 57 2.6E-38 T 21-04-2016 SPH21_RS03295 007b54166700c3ad3eadd1916d23b774 231 PANTHER PTHR11922:SF18 75 231 2.6E-38 T 21-04-2016 SPH21_RS03295 007b54166700c3ad3eadd1916d23b774 231 SUPERFAMILY SSF52317 14 215 7.37E-30 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 SUPERFAMILY SSF51735 1 102 1.85E-26 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 SUPERFAMILY SSF51735 215 243 1.85E-26 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 PIRSF PIRSF000161 1 246 6.0E-64 T 21-04-2016 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 PANTHER PTHR20836 1 245 1.5E-48 T 21-04-2016 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 Gene3D G3DSA:3.30.360.10 114 214 9.2E-28 T 21-04-2016 SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 TIGRFAM TIGR00036 dapB: 4-hydroxy-tetrahydrodipicolinate reductase 30 244 1.5E-44 T 21-04-2016 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 Gene3D G3DSA:3.40.50.720 1 113 8.6E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 Pfam PF05173 Dihydrodipicolinate reductase, C-terminus 106 242 1.1E-35 T 21-04-2016 IPR022663 Dihydrodipicolinate reductase, C-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 Pfam PF01113 Dihydrodipicolinate reductase, N-terminus 1 103 8.0E-15 T 21-04-2016 IPR000846 Dihydrodipicolinate reductase, N-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 SUPERFAMILY SSF55347 105 216 1.85E-22 T 21-04-2016 SPH21_RS02090 e8031b821b1b4ec70bcb3c867e54df21 246 Hamap MF_00102 4-hydroxy-tetrahydrodipicolinate reductase [dapB]. 1 244 24.42 T 21-04-2016 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS07415 7673a67e5de5a666c4c49e79fcfbb4ef 198 Pfam PF14595 Thioredoxin 31 160 2.6E-35 T 21-04-2016 SPH21_RS07415 7673a67e5de5a666c4c49e79fcfbb4ef 198 SUPERFAMILY SSF52833 67 152 5.61E-9 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07415 7673a67e5de5a666c4c49e79fcfbb4ef 198 Gene3D G3DSA:3.40.30.10 2 194 2.8E-42 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 Gene3D G3DSA:3.40.50.300 8 314 1.8E-99 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 PANTHER PTHR10285 1 260 1.8E-130 T 21-04-2016 SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 PANTHER PTHR10285 276 307 1.8E-130 T 21-04-2016 SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 TIGRFAM TIGR00554 panK_bact: pantothenate kinase 9 314 3.6E-129 T 21-04-2016 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961|UniPathway: UPA00241 SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 SUPERFAMILY SSF52540 7 314 6.68E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 Hamap MF_00215 Pantothenate kinase [coaA]. 1 315 151.06 T 21-04-2016 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961|UniPathway: UPA00241 SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 Pfam PF00485 Phosphoribulokinase / Uridine kinase family 88 240 9.8E-13 T 21-04-2016 IPR006083 Phosphoribulokinase/uridine kinase GO:0005524|GO:0008152|GO:0016301 SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 PIRSF PIRSF000545 1 315 2.0E-135 T 21-04-2016 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961|UniPathway: UPA00241 SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 PANTHER PTHR10285:SF7 1 260 1.8E-130 T 21-04-2016 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961|UniPathway: UPA00241 SPH21_RS17145 65ebfe2b8d34ae7696ad781e50d0872a 315 PANTHER PTHR10285:SF7 276 307 1.8E-130 T 21-04-2016 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961|UniPathway: UPA00241 SPH21_RS06635 ba501983cef38a88c52cabb01fa0de49 357 SUPERFAMILY SSF74650 12 353 8.37E-114 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS06635 ba501983cef38a88c52cabb01fa0de49 357 ProSitePatterns PS00545 Aldose 1-epimerase putative active site. 178 187 - T 21-04-2016 IPR018052 Aldose 1-epimerase, conserved site KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317|UniPathway: UPA00242 SPH21_RS06635 ba501983cef38a88c52cabb01fa0de49 357 PIRSF PIRSF005096 8 356 4.5E-134 T 21-04-2016 IPR015443 Aldose 1-epimerase GO:0016853|GO:0019318 KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317|UniPathway: UPA00242 SPH21_RS06635 ba501983cef38a88c52cabb01fa0de49 357 PANTHER PTHR10091:SF0 11 356 6.9E-156 T 21-04-2016 SPH21_RS06635 ba501983cef38a88c52cabb01fa0de49 357 Pfam PF01263 Aldose 1-epimerase 23 352 8.9E-88 T 21-04-2016 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 SPH21_RS06635 ba501983cef38a88c52cabb01fa0de49 357 PANTHER PTHR10091 11 356 6.9E-156 T 21-04-2016 SPH21_RS06635 ba501983cef38a88c52cabb01fa0de49 357 Gene3D G3DSA:2.70.98.10 12 356 3.2E-130 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 Gene3D G3DSA:2.40.170.20 569 910 3.0E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 Gene3D G3DSA:2.40.170.20 451 537 3.0E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 Gene3D G3DSA:2.40.170.20 957 976 3.0E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 SUPERFAMILY SSF56935 1052 1144 2.52E-83 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 SUPERFAMILY SSF56935 443 531 2.52E-83 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 SUPERFAMILY SSF56935 572 910 2.52E-83 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 SUPERFAMILY SSF56935 212 378 2.52E-83 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 SUPERFAMILY SSF56935 957 1007 2.52E-83 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 330 360 5.1E-13 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 132 1144 6.8E-187 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 Pfam PF13715 CarboxypepD_reg-like domain 134 215 7.5E-14 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 Gene3D G3DSA:2.60.40.1120 133 216 1.8E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 SUPERFAMILY SSF49464 132 213 3.27E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 Gene3D G3DSA:2.170.130.10 217 357 2.2E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 Pfam PF07715 TonB-dependent Receptor Plug Domain 225 353 1.1E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 PANTHER PTHR11532 647 1142 1.4E-204 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 PANTHER PTHR11532 100 298 1.4E-204 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 PANTHER PTHR11532 321 569 1.4E-204 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 PANTHER PTHR11532:SF51 647 1142 1.4E-204 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 PANTHER PTHR11532:SF51 100 298 1.4E-204 T 21-04-2016 SPH21_RS13760 de05b7b9c986c221e5b516719b66dbd2 1144 PANTHER PTHR11532:SF51 321 569 1.4E-204 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 155 180 8.1E-10 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 293 300 8.1E-10 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 2 24 8.1E-10 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 SUPERFAMILY SSF51905 2 337 1.36E-32 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 3 22 1.1E-11 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 155 173 1.1E-11 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 278 300 1.1E-11 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 95 113 1.1E-11 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PANTHER PTHR22912 1 35 5.0E-23 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PANTHER PTHR22912 192 333 5.0E-23 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PANTHER PTHR22912 53 137 5.0E-23 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 PANTHER PTHR22912 154 175 5.0E-23 T 21-04-2016 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 2 323 1.3E-48 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 Gene3D G3DSA:3.50.50.60 1 101 7.3E-21 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08445 8f16365856522761fb61bc633d7d1d3e 431 Gene3D G3DSA:3.50.50.60 102 331 4.8E-30 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15930 b9d7b7937d307b118db1de7c4c04f2ed 122 SMART SM00448 3 114 1.4E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15930 b9d7b7937d307b118db1de7c4c04f2ed 122 Pfam PF00072 Response regulator receiver domain 5 112 1.1E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15930 b9d7b7937d307b118db1de7c4c04f2ed 122 PANTHER PTHR26402 3 122 3.4E-23 T 21-04-2016 SPH21_RS15930 b9d7b7937d307b118db1de7c4c04f2ed 122 Gene3D G3DSA:3.40.50.2300 4 121 2.2E-24 T 21-04-2016 SPH21_RS15930 b9d7b7937d307b118db1de7c4c04f2ed 122 SUPERFAMILY SSF52172 4 120 8.4E-25 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 SMART SM00072 2 187 2.1E-47 T 21-04-2016 IPR008145 Guanylate kinase/L-type calcium channel beta subunit SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 Gene3D G3DSA:3.30.63.10 44 86 3.8E-23 T 21-04-2016 SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 PANTHER PTHR23117 3 178 2.1E-74 T 21-04-2016 SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 Hamap MF_00328 Guanylate kinase [gmk]. 1 187 33.615 T 21-04-2016 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221 SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 Pfam PF00625 Guanylate kinase 3 183 1.2E-52 T 21-04-2016 IPR008145 Guanylate kinase/L-type calcium channel beta subunit SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 TIGRFAM TIGR03263 guanyl_kin: guanylate kinase 3 183 1.8E-63 T 21-04-2016 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221 SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 Gene3D G3DSA:3.40.50.300 2 43 4.5E-4 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 ProSitePatterns PS00856 Guanylate kinase-like signature. 38 55 - T 21-04-2016 IPR020590 Guanylate kinase, conserved site KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221 SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 Gene3D G3DSA:3.40.50.300 87 183 1.2E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07470 b30c58a1d7a52bdd4391c6bb26cda544 188 SUPERFAMILY SSF52540 2 184 1.09E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05620 71baabc25ec46d475eb38cb4b20c392c 425 Gene3D G3DSA:2.70.70.10 279 422 6.7E-27 T 21-04-2016 SPH21_RS05620 71baabc25ec46d475eb38cb4b20c392c 425 PANTHER PTHR21666 27 422 3.6E-42 T 21-04-2016 SPH21_RS05620 71baabc25ec46d475eb38cb4b20c392c 425 PANTHER PTHR21666:SF200 27 422 3.6E-42 T 21-04-2016 SPH21_RS05620 71baabc25ec46d475eb38cb4b20c392c 425 SUPERFAMILY SSF51261 216 422 2.51E-25 T 21-04-2016 IPR011055 Duplicated hybrid motif SPH21_RS05620 71baabc25ec46d475eb38cb4b20c392c 425 Pfam PF01551 Peptidase family M23 327 418 4.8E-17 T 21-04-2016 IPR016047 Peptidase M23 SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 PANTHER PTHR34218:SF2 33 827 9.0E-180 T 21-04-2016 SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 Pfam PF01804 Penicillin amidase 63 807 1.1E-203 T 21-04-2016 IPR002692 Penicillin/cephalosporin acylase GO:0016787|GO:0017000 SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 Gene3D G3DSA:3.60.20.10 289 364 1.8E-92 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 Gene3D G3DSA:3.60.20.10 450 679 1.8E-92 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 Gene3D G3DSA:2.30.120.10 365 440 1.1E-15 T 21-04-2016 SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 PANTHER PTHR34218 33 827 9.0E-180 T 21-04-2016 SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 PIRSF PIRSF001227 31 821 8.3E-183 T 21-04-2016 IPR014395 Penicillin acylase GO:0016811 SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 Gene3D G3DSA:1.10.439.10 51 215 1.7E-46 T 21-04-2016 IPR023343 Penicillin amidase type, domain1 GO:0016811 SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 SUPERFAMILY SSF56235 277 809 6.17E-203 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS19385 504033c9dddf458385aab5471ca5a55a 827 SUPERFAMILY SSF56235 58 248 6.17E-203 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 Pfam PF10415 Fumarase C C-terminus 409 462 1.4E-28 T 21-04-2016 IPR018951 Fumarase C, C-terminal GO:0006099|GO:0016829 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 TIGRFAM TIGR00979 fumC_II: fumarate hydratase, class II 3 462 6.9E-240 T 21-04-2016 IPR005677 Fumarate hydratase, class II GO:0004333|GO:0006106|GO:0045239 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 PANTHER PTHR11444 1 462 6.9E-254 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 Pfam PF00206 Lyase 11 343 4.3E-111 T 21-04-2016 IPR022761 Fumarate lyase, N-terminal SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 Hamap MF_00743 Fumarate hydratase class II [fumC]. 3 463 89.658 T 21-04-2016 IPR005677 Fumarate hydratase, class II GO:0004333|GO:0006106|GO:0045239 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 Gene3D G3DSA:1.10.275.10 2 139 1.5E-59 T 21-04-2016 IPR024083 Fumarase/histidase, N-terminal SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 PRINTS PR00149 Fumarate lyase superfamily signature 135 153 3.5E-36 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 PRINTS PR00149 Fumarate lyase superfamily signature 181 199 3.5E-36 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 PRINTS PR00149 Fumarate lyase superfamily signature 318 334 3.5E-36 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 PRINTS PR00149 Fumarate lyase superfamily signature 272 299 3.5E-36 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 PANTHER PTHR11444:SF1 1 462 6.9E-254 T 21-04-2016 SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 ProSitePatterns PS00163 Fumarate lyases signature. 318 327 - T 21-04-2016 IPR020557 Fumarate lyase, conserved site GO:0003824 SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 SUPERFAMILY SSF48557 3 461 2.04E-154 T 21-04-2016 IPR008948 L-Aspartase-like GO:0003824 SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 Gene3D G3DSA:1.10.40.30 418 462 1.5E-32 T 21-04-2016 SPH21_RS07525 95ae018b21b7d5876c057016854c5733 465 Gene3D G3DSA:1.20.200.10 140 417 5.6E-104 T 21-04-2016 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 ProSitePatterns PS00211 ABC transporters family signature. 628 642 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 Pfam PF03412 Peptidase C39 family 16 149 1.7E-27 T 21-04-2016 IPR005074 Peptidase C39, bacteriocin processing GO:0005524|GO:0006508|GO:0008233|GO:0016021 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 Gene3D G3DSA:1.20.1560.10 164 473 2.7E-53 T 21-04-2016 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 Gene3D G3DSA:3.40.50.300 492 688 6.0E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 Pfam PF00005 ABC transporter 509 656 5.9E-27 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 Pfam PF00664 ABC transporter transmembrane region 179 442 1.7E-24 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 PANTHER PTHR24221 155 670 2.7E-106 T 21-04-2016 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 SUPERFAMILY SSF90123 161 471 4.32E-52 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 SMART SM00382 517 703 2.0E-13 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 Gene3D G3DSA:3.90.70.10 20 144 2.9E-9 T 21-04-2016 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 PANTHER PTHR24221:SF138 155 670 2.7E-106 T 21-04-2016 SPH21_RS02935 084597d5473811f74185308ebaf6caa2 703 SUPERFAMILY SSF52540 490 688 8.52E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 PANTHER PTHR32552:SF15 132 772 2.0E-30 T 21-04-2016 SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 Pfam PF00593 TonB dependent receptor 514 770 7.5E-18 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 PANTHER PTHR32552 132 772 2.0E-30 T 21-04-2016 SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 Pfam PF13715 CarboxypepD_reg-like domain 30 113 7.3E-14 T 21-04-2016 SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 SUPERFAMILY SSF56935 113 772 7.69E-77 T 21-04-2016 SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 Gene3D G3DSA:2.60.40.1120 30 102 1.1E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 Pfam PF07715 TonB-dependent Receptor Plug Domain 123 225 3.0E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 Gene3D G3DSA:2.40.170.20 225 771 3.8E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 SUPERFAMILY SSF49464 28 113 9.02E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS12635 7468120f93bd87e8ae8c7168fcb72ea1 772 Gene3D G3DSA:2.170.130.10 115 224 3.6E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 SMART SM00420 6 58 3.0E-10 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 SUPERFAMILY SSF46785 4 59 4.92E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 Pfam PF00455 DeoR C terminal sensor domain 76 230 1.9E-37 T 21-04-2016 IPR014036 DeoR C-terminal sensor domain SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 SUPERFAMILY SSF100950 76 232 2.72E-20 T 21-04-2016 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 SMART SM01134 71 232 2.6E-38 T 21-04-2016 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 2.7E-6 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 2.7E-6 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 21-04-2016 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 PANTHER PTHR30363 1 249 4.0E-53 T 21-04-2016 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 Gene3D G3DSA:1.10.10.10 1 60 3.0E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 Gene3D G3DSA:3.40.50.1360 75 213 7.6E-6 T 21-04-2016 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 PANTHER PTHR30363:SF13 1 249 4.0E-53 T 21-04-2016 SPH21_RS19100 f8cd0b429b34dd5ef8ac65b2f366b3af 249 Pfam PF08220 DeoR-like helix-turn-helix domain 6 60 2.8E-13 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS12605 2c47dd0b45ca5664bd23c4f9fd4e1a35 431 Pfam PF11013 Protein of unknown function (DUF2851) 5 380 3.0E-141 T 21-04-2016 IPR021272 Protein of unknown function DUF2851 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 PANTHER PTHR31490 49 279 1.4E-92 T 21-04-2016 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 PANTHER PTHR31490 300 369 1.4E-92 T 21-04-2016 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 Pfam PF00331 Glycosyl hydrolase family 10 41 369 4.5E-108 T 21-04-2016 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784|UniPathway: UPA00114 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 SUPERFAMILY SSF51445 37 370 1.89E-109 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 SMART SM00633 81 371 3.2E-126 T 21-04-2016 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784|UniPathway: UPA00114 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 Gene3D G3DSA:3.20.20.80 42 370 1.8E-115 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 ProSitePatterns PS00591 Glycosyl hydrolases family 10 (GH10) active site. 268 278 - T 21-04-2016 IPR031158 Glycosyl hydrolases family 10, active site MetaCyc: PWY-6784 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 PRINTS PR00134 Glycosyl hydrolase family 10 signature 206 217 9.0E-18 T 21-04-2016 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784|UniPathway: UPA00114 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 PRINTS PR00134 Glycosyl hydrolase family 10 signature 234 246 9.0E-18 T 21-04-2016 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784|UniPathway: UPA00114 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 PRINTS PR00134 Glycosyl hydrolase family 10 signature 160 171 9.0E-18 T 21-04-2016 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784|UniPathway: UPA00114 SPH21_RS13170 3b900a235e6d772d795df6866a5d4248 372 PRINTS PR00134 Glycosyl hydrolase family 10 signature 112 124 9.0E-18 T 21-04-2016 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784|UniPathway: UPA00114 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 Pfam PF13620 Carboxypeptidase regulatory-like domain 28 109 1.3E-18 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 PANTHER PTHR30069:SF6 1 367 1.8E-23 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 PANTHER PTHR30069:SF6 821 863 1.8E-23 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 PANTHER PTHR30069 1 367 1.8E-23 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 PANTHER PTHR30069 821 863 1.8E-23 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 Gene3D G3DSA:2.60.40.1120 29 125 3.8E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF56935 704 748 6.87E-39 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF56935 867 903 6.87E-39 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF56935 966 1013 6.87E-39 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF56935 1042 1058 6.87E-39 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF56935 351 652 6.87E-39 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF56935 791 836 6.87E-39 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF56935 108 308 6.87E-39 T 21-04-2016 SPH21_RS15360 8ae9bc46b565544600510b024dc2e87a 1058 SUPERFAMILY SSF49464 27 119 1.61E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 Hamap MF_00455 Xylose isomerase [xylA]. 17 442 51.277 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 SUPERFAMILY SSF51658 9 442 1.52E-156 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PANTHER PTHR32176 7 442 3.2E-246 T 21-04-2016 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 Gene3D G3DSA:3.20.20.150 9 442 1.4E-193 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 TIGRFAM TIGR02630 xylose_isom_A: xylose isomerase 10 442 2.4E-204 T 21-04-2016 IPR013452 Xylose isomerase, bacterial-type GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PANTHER PTHR32176:SF0 7 442 3.2E-246 T 21-04-2016 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 235 259 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 186 207 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 98 120 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 213 232 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 277 304 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 339 350 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 139 159 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 306 317 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS19675 5caaa33a81e26b766e10642ca5fc8229 442 PRINTS PR00688 Xylose isomerase signature 162 181 3.9E-78 T 21-04-2016 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SPH21_RS04030 363e313ed6bb11dd15ec57ffcc442b9b 235 PANTHER PTHR10681:SF70 68 172 9.4E-33 T 21-04-2016 SPH21_RS04030 363e313ed6bb11dd15ec57ffcc442b9b 235 PANTHER PTHR10681:SF70 192 232 9.4E-33 T 21-04-2016 SPH21_RS04030 363e313ed6bb11dd15ec57ffcc442b9b 235 Gene3D G3DSA:3.40.30.10 64 229 3.5E-31 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS04030 363e313ed6bb11dd15ec57ffcc442b9b 235 SUPERFAMILY SSF52833 64 228 4.5E-37 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS04030 363e313ed6bb11dd15ec57ffcc442b9b 235 PANTHER PTHR10681 68 172 9.4E-33 T 21-04-2016 SPH21_RS04030 363e313ed6bb11dd15ec57ffcc442b9b 235 PANTHER PTHR10681 192 232 9.4E-33 T 21-04-2016 SPH21_RS04030 363e313ed6bb11dd15ec57ffcc442b9b 235 Pfam PF00578 AhpC/TSA family 68 208 1.9E-28 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS11385 5c757ee60426b4f1985647f792e00215 1045 Gene3D G3DSA:2.160.20.10 200 352 1.2E-12 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS11385 5c757ee60426b4f1985647f792e00215 1045 Gene3D G3DSA:2.160.20.10 82 148 1.2E-12 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS11385 5c757ee60426b4f1985647f792e00215 1045 SUPERFAMILY SSF51126 268 386 1.45E-13 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS11385 5c757ee60426b4f1985647f792e00215 1045 SUPERFAMILY SSF51126 81 162 1.45E-13 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS22540 8414fcd81cd96d977494829d5129ae6c 142 Pfam PF12680 SnoaL-like domain 18 124 5.9E-10 T 21-04-2016 IPR009959 Polyketide cyclase SnoaL-like domain SPH21_RS22540 8414fcd81cd96d977494829d5129ae6c 142 SUPERFAMILY SSF54427 11 139 1.8E-22 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS22540 8414fcd81cd96d977494829d5129ae6c 142 Gene3D G3DSA:3.10.450.50 10 141 4.2E-29 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 Pfam PF00365 Phosphofructokinase 1 262 2.6E-97 T 21-04-2016 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PIRSF PIRSF000532 1 309 7.1E-106 T 21-04-2016 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 Gene3D G3DSA:3.40.50.450 1 199 6.3E-66 T 21-04-2016 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 ProSitePatterns PS00433 Phosphofructokinase signature. 232 250 - T 21-04-2016 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PANTHER PTHR13697:SF4 1 290 4.6E-118 T 21-04-2016 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 SUPERFAMILY SSF53784 1 290 7.72E-103 T 21-04-2016 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 106 123 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 78 94 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 162 179 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 16 29 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 124 142 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 198 210 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 144 160 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 228 250 2.6E-64 T 21-04-2016 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 TIGRFAM TIGR02482 PFKA_ATP: 6-phosphofructokinase 1 287 9.3E-116 T 21-04-2016 IPR012828 ATP-dependent 6-phosphofructokinase, prokaryotic GO:0003872|GO:0005524|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS19335 9619b772d16329a6246d305c2261109f 309 PANTHER PTHR13697 1 290 4.6E-118 T 21-04-2016 SPH21_RS08360 ab50180be9c8b3cb02922af514c205e3 181 Gene3D G3DSA:2.60.40.420 60 179 3.9E-38 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS08360 ab50180be9c8b3cb02922af514c205e3 181 Pfam PF00127 Copper binding proteins, plastocyanin/azurin family 65 179 1.2E-17 T 21-04-2016 IPR000923 Blue (type 1) copper domain GO:0005507|GO:0009055 SPH21_RS08360 ab50180be9c8b3cb02922af514c205e3 181 ProDom PD003655 COPPER ELECTRON AZURIN METAL-BINDING PERIPLASMIC PRECURSOR SIGNAL SEQUENCING DIRECT MEMBRANE 61 178 5.0E-17 T 21-04-2016 SPH21_RS08360 ab50180be9c8b3cb02922af514c205e3 181 PANTHER PTHR38439 34 181 1.3E-22 T 21-04-2016 SPH21_RS08360 ab50180be9c8b3cb02922af514c205e3 181 ProSitePatterns PS00196 Type-1 copper (blue) proteins signature. 158 175 - T 21-04-2016 IPR028871 Blue (type 1) copper protein, binding site SPH21_RS08360 ab50180be9c8b3cb02922af514c205e3 181 SUPERFAMILY SSF49503 60 179 7.37E-33 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS08360 ab50180be9c8b3cb02922af514c205e3 181 PANTHER PTHR38439:SF2 34 181 1.3E-22 T 21-04-2016 SPH21_RS25660 e590a6cde84bff10bb6f7fbedf6f7f69 284 PANTHER PTHR11048:SF7 1 280 2.5E-57 T 21-04-2016 SPH21_RS25660 e590a6cde84bff10bb6f7fbedf6f7f69 284 PANTHER PTHR11048 1 280 2.5E-57 T 21-04-2016 SPH21_RS25660 e590a6cde84bff10bb6f7fbedf6f7f69 284 Pfam PF01040 UbiA prenyltransferase family 17 264 9.2E-52 T 21-04-2016 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SPH21_RS25660 e590a6cde84bff10bb6f7fbedf6f7f69 284 TIGRFAM TIGR01475 ubiA_other: putative 4-hydroxybenzoate polyprenyltransferase 2 282 1.1E-88 T 21-04-2016 IPR006371 4-hydroxybenzoate polyprenyltransferase-related SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 SUPERFAMILY SSF47005 220 257 6.93E-10 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 289 517 1.7E-81 T 21-04-2016 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 PANTHER PTHR23151:SF47 7 519 1.6E-208 T 21-04-2016 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Gene3D G3DSA:3.30.559.10 280 517 8.6E-91 T 21-04-2016 IPR023213 Chloramphenicol acetyltransferase-like domain SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 SUPERFAMILY SSF52777 289 517 8.45E-88 T 21-04-2016 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 136 165 - T 21-04-2016 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 27 56 - T 21-04-2016 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Gene3D G3DSA:4.10.320.10 222 257 5.2E-17 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 SUPERFAMILY SSF51230 111 203 1.2E-23 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Pfam PF02817 e3 binding domain 222 254 8.3E-14 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 SUPERFAMILY SSF51230 1 90 4.84E-24 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 TIGRFAM TIGR01347 sucB: dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex 112 518 1.8E-163 T 21-04-2016 IPR006255 Dihydrolipoamide succinyltransferase GO:0004149|GO:0006099|GO:0045252 KEGG: 00020+2.3.1.61|KEGG: 00310+2.3.1.61|MetaCyc: PWY-5084|UniPathway: UPA00868 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 PANTHER PTHR23151 7 519 1.6E-208 T 21-04-2016 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Gene3D G3DSA:2.40.50.100 1 93 2.5E-26 T 21-04-2016 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Gene3D G3DSA:2.40.50.100 110 203 6.3E-25 T 21-04-2016 SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Pfam PF00364 Biotin-requiring enzyme 4 75 5.3E-18 T 21-04-2016 IPR000089 Biotin/lipoyl attachment SPH21_RS08340 779402d65ea97bd056b4b77449958c28 519 Pfam PF00364 Biotin-requiring enzyme 113 184 2.1E-17 T 21-04-2016 IPR000089 Biotin/lipoyl attachment SPH21_RS23460 7d806d1f1b363934c97ba452c0c7d779 188 Pfam PF08534 Redoxin 56 168 2.7E-17 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS23460 7d806d1f1b363934c97ba452c0c7d779 188 PANTHER PTHR10681 53 167 5.9E-19 T 21-04-2016 SPH21_RS23460 7d806d1f1b363934c97ba452c0c7d779 188 SUPERFAMILY SSF52833 16 184 2.48E-31 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS23460 7d806d1f1b363934c97ba452c0c7d779 188 PANTHER PTHR10681:SF125 53 167 5.9E-19 T 21-04-2016 SPH21_RS23460 7d806d1f1b363934c97ba452c0c7d779 188 Gene3D G3DSA:3.40.30.10 13 185 1.3E-38 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS14500 571ae9c1d57f1c446e6440efa25c7c2d 84 Pfam PF11127 Protein of unknown function (DUF2892) 15 72 1.4E-6 T 21-04-2016 IPR021309 Protein of unknown function DUF2892 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 SUPERFAMILY SSF82714 182 264 6.28E-14 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PANTHER PTHR32063 2 1048 0.0 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 Gene3D G3DSA:1.10.3850.10 817 1041 2.0E-39 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 Gene3D G3DSA:1.10.3850.10 291 503 1.8E-51 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 SUPERFAMILY SSF82866 300 500 9.55E-36 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PANTHER PTHR32063:SF17 2 1048 0.0 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 Gene3D G3DSA:3.30.70.1430 45 140 6.7E-21 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 Gene3D G3DSA:3.30.2090.10 182 264 2.1E-15 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 Gene3D G3DSA:3.30.2090.10 727 808 3.8E-20 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 Pfam PF00873 AcrB/AcrD/AcrF family 8 1036 3.6E-233 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 SUPERFAMILY SSF82866 810 1043 8.37E-36 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PRINTS PR00702 Acriflavin resistance protein family signature 554 571 3.2E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PRINTS PR00702 Acriflavin resistance protein family signature 40 58 3.2E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PRINTS PR00702 Acriflavin resistance protein family signature 474 497 3.2E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PRINTS PR00702 Acriflavin resistance protein family signature 337 360 3.2E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PRINTS PR00702 Acriflavin resistance protein family signature 364 385 3.2E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 PRINTS PR00702 Acriflavin resistance protein family signature 449 472 3.2E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 SUPERFAMILY SSF82693 45 125 2.62E-18 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 TIGRFAM TIGR00914 2A0601: heavy metal efflux pump, CzcA family 1 1047 3.8E-262 T 21-04-2016 IPR004763 Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA GO:0006812|GO:0008324|GO:0016021 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 SUPERFAMILY SSF82693 142 181 1.96E-12 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 SUPERFAMILY SSF82693 274 331 1.96E-12 T 21-04-2016 SPH21_RS16695 144ffeeab39749aebd59e200b6759983 1052 SUPERFAMILY SSF82714 727 808 3.92E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS25360 30b46ac5cfd50685bae53231a94c224a 114 SUPERFAMILY SSF52833 1 113 1.21E-27 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS25360 30b46ac5cfd50685bae53231a94c224a 114 Gene3D G3DSA:3.40.30.10 1 113 2.9E-36 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS25360 30b46ac5cfd50685bae53231a94c224a 114 PANTHER PTHR30041 1 110 3.6E-29 T 21-04-2016 SPH21_RS25360 30b46ac5cfd50685bae53231a94c224a 114 PANTHER PTHR30041:SF3 1 110 3.6E-29 T 21-04-2016 SPH21_RS25360 30b46ac5cfd50685bae53231a94c224a 114 Pfam PF03960 ArsC family 5 111 8.1E-14 T 21-04-2016 IPR006660 Arsenate reductase-like SPH21_RS25360 30b46ac5cfd50685bae53231a94c224a 114 TIGRFAM TIGR01617 arsC_related: transcriptional regulator, Spx/MgsR family 1 112 2.2E-27 T 21-04-2016 IPR006504 Transcriptional regulator Spx/MgsR SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 PANTHER PTHR23531 1 385 3.1E-49 T 21-04-2016 SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 Pfam PF07690 Major Facilitator Superfamily 14 185 8.3E-26 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 Pfam PF07690 Major Facilitator Superfamily 212 377 8.1E-24 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 PRINTS PR01035 Tetracycline resistance protein signature 133 155 3.4E-5 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 PRINTS PR01035 Tetracycline resistance protein signature 19 35 3.4E-5 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 PRINTS PR01035 Tetracycline resistance protein signature 103 124 3.4E-5 T 21-04-2016 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 SUPERFAMILY SSF103473 8 385 4.58E-61 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 Gene3D G3DSA:1.20.1250.20 207 385 3.6E-28 T 21-04-2016 SPH21_RS01010 3dc505556dfee9b4595d45fbe90b02d4 389 Gene3D G3DSA:1.20.1250.20 9 189 2.9E-33 T 21-04-2016 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 SUPERFAMILY SSF51011 609 688 2.95E-16 T 21-04-2016 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 ProSitePatterns PS00129 Glycosyl hydrolases family 31 active site. 423 430 - T 21-04-2016 IPR030458 Glycosyl hydrolases family 31, active site SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 Pfam PF01055 Glycosyl hydrolases family 31 253 693 1.2E-147 T 21-04-2016 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 PANTHER PTHR22762 63 807 1.6E-248 T 21-04-2016 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 PANTHER PTHR22762:SF7 63 807 1.6E-248 T 21-04-2016 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 Gene3D G3DSA:3.20.20.70 396 513 3.3E-7 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 Gene3D G3DSA:3.20.20.70 293 359 3.3E-7 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 Pfam PF16338 Domain of unknown function (DUF4968) 48 140 2.9E-23 T 21-04-2016 IPR032513 Alpha-glucosidase, domain of unknown function DUF4968 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 Pfam PF17137 Domain of unknown function (DUF5110) 710 777 1.9E-6 T 21-04-2016 IPR033403 Domain of unknown function DUF5110 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 Pfam PF13802 Galactose mutarotase-like 167 232 2.9E-22 T 21-04-2016 IPR025887 Glycoside hydrolase family 31, N-terminal domain SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 SUPERFAMILY SSF74650 38 259 1.04E-51 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS25295 b5ebb166ebeba253ac0055fa898ae8b8 815 SUPERFAMILY SSF51445 262 607 1.17E-93 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 SUPERFAMILY SSF49464 45 124 1.7E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Gene3D G3DSA:2.170.130.10 129 254 8.0E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Pfam PF07715 TonB-dependent Receptor Plug Domain 136 254 1.8E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 PANTHER PTHR11532:SF57 558 1078 1.5E-253 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 PANTHER PTHR11532:SF57 8 445 1.5E-253 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 230 260 2.6E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Gene3D G3DSA:2.40.170.20 910 935 7.2E-60 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Gene3D G3DSA:2.40.170.20 255 280 7.2E-60 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Gene3D G3DSA:2.40.170.20 366 857 7.2E-60 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Gene3D G3DSA:2.40.170.20 979 1080 7.2E-60 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Gene3D G3DSA:2.60.40.1120 45 128 3.5E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 45 1080 5.6E-263 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 Pfam PF13715 CarboxypepD_reg-like domain 46 126 2.0E-17 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 PANTHER PTHR11532 558 1078 1.5E-253 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 PANTHER PTHR11532 8 445 1.5E-253 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 SUPERFAMILY SSF56935 122 278 1.32E-102 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 SUPERFAMILY SSF56935 480 828 1.32E-102 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 SUPERFAMILY SSF56935 357 445 1.32E-102 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 SUPERFAMILY SSF56935 984 1080 1.32E-102 T 21-04-2016 SPH21_RS02350 a8f59295bf04f6c5b5815d17fedc64f4 1080 SUPERFAMILY SSF56935 901 945 1.32E-102 T 21-04-2016 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 PANTHER PTHR30173 1 195 7.1E-43 T 21-04-2016 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 Pfam PF08281 Sigma-70, region 4 125 176 1.2E-16 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 Pfam PF04542 Sigma-70 region 2 28 91 2.9E-12 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 179 6.4E-28 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 Gene3D G3DSA:1.10.1740.10 7 97 2.2E-23 T 21-04-2016 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 SUPERFAMILY SSF88659 121 182 2.8E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 SUPERFAMILY SSF88946 7 97 1.77E-23 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 22 178 1.8E-42 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 Gene3D G3DSA:1.10.10.10 124 181 7.4E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21340 9e80c4b945f0466a7b61a7ef688f345e 199 PANTHER PTHR30173:SF20 1 195 7.1E-43 T 21-04-2016 SPH21_RS08965 fcb7dc3889088df2283f4442d7a23833 395 SUPERFAMILY SSF51735 33 305 4.15E-27 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08965 fcb7dc3889088df2283f4442d7a23833 395 PANTHER PTHR10366:SF256 33 253 1.3E-22 T 21-04-2016 SPH21_RS08965 fcb7dc3889088df2283f4442d7a23833 395 Gene3D G3DSA:3.40.50.720 31 241 1.9E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08965 fcb7dc3889088df2283f4442d7a23833 395 Pfam PF02719 Polysaccharide biosynthesis protein 35 327 8.8E-44 T 21-04-2016 IPR003869 Polysaccharide biosynthesis protein, CapD-like domain SPH21_RS08965 fcb7dc3889088df2283f4442d7a23833 395 PANTHER PTHR10366 33 253 1.3E-22 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 TIGRFAM TIGR00914 2A0601: heavy metal efflux pump, CzcA family 2 1015 0.0 T 21-04-2016 IPR004763 Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA GO:0006812|GO:0008324|GO:0016021 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82693 136 171 3.31E-18 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82693 258 315 3.31E-18 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82866 281 487 4.19E-33 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Pfam PF00873 AcrB/AcrD/AcrF family 1 1013 6.6E-289 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82693 25 113 6.02E-21 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PANTHER PTHR32063 1 1059 0.0 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82714 707 792 6.67E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82693 552 649 2.35E-5 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Gene3D G3DSA:3.30.2090.10 172 253 1.1E-13 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Gene3D G3DSA:3.30.2090.10 707 792 2.2E-14 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Pfam PF02321 Outer membrane efflux protein 1057 1231 1.2E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Pfam PF02321 Outer membrane efflux protein 1255 1441 9.5E-19 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Gene3D G3DSA:1.10.3850.10 798 1015 5.9E-57 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Gene3D G3DSA:1.10.3850.10 265 489 2.2E-49 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Gene3D G3DSA:1.20.1600.10 1054 1441 7.1E-62 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82866 790 1017 9.81E-52 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF56954 1023 1441 6.28E-51 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 Gene3D G3DSA:3.30.70.1430 25 125 4.2E-25 T 21-04-2016 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PRINTS PR00702 Acriflavin resistance protein family signature 435 458 6.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PRINTS PR00702 Acriflavin resistance protein family signature 23 41 6.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PRINTS PR00702 Acriflavin resistance protein family signature 536 553 6.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PRINTS PR00702 Acriflavin resistance protein family signature 460 483 6.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PRINTS PR00702 Acriflavin resistance protein family signature 321 344 6.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PRINTS PR00702 Acriflavin resistance protein family signature 348 369 6.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 SUPERFAMILY SSF82714 172 254 5.75E-13 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS18255 370173c7679c12005fb7f0444638aa7f 1442 PANTHER PTHR32063:SF24 1 1059 0.0 T 21-04-2016 SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 PIRSF PIRSF010631 1 926 6.1E-199 T 21-04-2016 IPR016007 Alpha-L-rhamnosidase SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 PANTHER PTHR33307 560 895 7.0E-195 T 21-04-2016 SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 PANTHER PTHR33307 1 535 7.0E-195 T 21-04-2016 SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 Gene3D G3DSA:2.60.120.260 127 240 3.2E-7 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 181 349 6.0E-29 T 21-04-2016 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 Gene3D G3DSA:2.60.40.10 82 126 8.2E-4 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 Pfam PF05592 Bacterial alpha-L-rhamnosidase 364 890 4.9E-112 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 PANTHER PTHR33307:SF5 560 895 7.0E-195 T 21-04-2016 SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 PANTHER PTHR33307:SF5 1 535 7.0E-195 T 21-04-2016 SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 SUPERFAMILY SSF49785 114 243 9.21E-9 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02185 bef021d6b037125d49d69dc8ae8012b8 926 SUPERFAMILY SSF48208 464 892 1.94E-34 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS05725 6ffbf2d92e3339d40111e2758e12cf50 959 SUPERFAMILY SSF56935 807 923 1.53E-12 T 21-04-2016 SPH21_RS05725 6ffbf2d92e3339d40111e2758e12cf50 959 SUPERFAMILY SSF56935 330 440 1.53E-12 T 21-04-2016 SPH21_RS05725 6ffbf2d92e3339d40111e2758e12cf50 959 SUPERFAMILY SSF56935 489 753 1.53E-12 T 21-04-2016 SPH21_RS05725 6ffbf2d92e3339d40111e2758e12cf50 959 SUPERFAMILY SSF56935 118 297 1.53E-12 T 21-04-2016 SPH21_RS05725 6ffbf2d92e3339d40111e2758e12cf50 959 Pfam PF14905 Outer membrane protein beta-barrel family 462 921 5.7E-39 T 21-04-2016 SPH21_RS05725 6ffbf2d92e3339d40111e2758e12cf50 959 SUPERFAMILY SSF49464 35 106 1.14E-7 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 SUPERFAMILY SSF53328 1 192 2.22E-58 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 Gene3D G3DSA:3.10.25.10 209 303 4.1E-30 T 21-04-2016 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 SUPERFAMILY SSF50486 208 306 8.48E-27 T 21-04-2016 IPR011034 Formyl transferase, C-terminal-like GO:0003824 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 TIGRFAM TIGR00460 fmt: methionyl-tRNA formyltransferase 1 306 3.9E-80 T 21-04-2016 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 Pfam PF00551 Formyl transferase 1 178 1.4E-37 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 Gene3D G3DSA:3.40.50.170 1 194 1.1E-64 T 21-04-2016 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 PANTHER PTHR11138 1 308 1.0E-103 T 21-04-2016 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 Hamap MF_00182 Methionyl-tRNA formyltransferase [fmt]. 1 308 33.976 T 21-04-2016 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS17655 adea99d645677d9a2a686f89303334b1 308 Pfam PF02911 Formyl transferase, C-terminal domain 206 305 4.1E-27 T 21-04-2016 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SPH21_RS10455 855d0c937a1b964141a17dad43f49ae4 760 PANTHER PTHR12526 1 414 1.1E-99 T 21-04-2016 SPH21_RS10455 855d0c937a1b964141a17dad43f49ae4 760 Pfam PF00534 Glycosyl transferases group 1 181 354 3.4E-11 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS10455 855d0c937a1b964141a17dad43f49ae4 760 Gene3D G3DSA:3.40.50.2000 154 354 2.7E-8 T 21-04-2016 SPH21_RS10455 855d0c937a1b964141a17dad43f49ae4 760 Pfam PF13439 Glycosyltransferase Family 4 68 169 4.3E-8 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS10455 855d0c937a1b964141a17dad43f49ae4 760 SUPERFAMILY SSF48208 468 739 6.38E-6 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS10455 855d0c937a1b964141a17dad43f49ae4 760 SUPERFAMILY SSF53756 2 372 1.31E-43 T 21-04-2016 SPH21_RS10455 855d0c937a1b964141a17dad43f49ae4 760 PANTHER PTHR12526:SF370 1 414 1.1E-99 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 1005 3.4E-254 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 Gene3D G3DSA:2.40.170.20 833 1005 1.6E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 Gene3D G3DSA:2.40.170.20 306 775 1.6E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 Gene3D G3DSA:2.40.170.20 223 245 1.6E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 Pfam PF13715 CarboxypepD_reg-like domain 28 109 7.5E-20 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 Gene3D G3DSA:2.60.40.1120 27 112 3.4E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 198 228 1.5E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 Gene3D G3DSA:2.170.130.10 113 222 1.2E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 SUPERFAMILY SSF56935 297 766 5.49E-75 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 SUPERFAMILY SSF56935 824 868 5.49E-75 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 SUPERFAMILY SSF56935 900 966 5.49E-75 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 SUPERFAMILY SSF56935 105 246 5.49E-75 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 Pfam PF07715 TonB-dependent Receptor Plug Domain 119 222 2.9E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 PANTHER PTHR11532:SF57 989 1003 6.0E-243 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 PANTHER PTHR11532:SF57 1 408 6.0E-243 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 PANTHER PTHR11532:SF57 484 968 6.0E-243 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 PANTHER PTHR11532 989 1003 6.0E-243 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 PANTHER PTHR11532 1 408 6.0E-243 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 PANTHER PTHR11532 484 968 6.0E-243 T 21-04-2016 SPH21_RS06985 8be80c401df1d7dd664caebc5a050586 1005 SUPERFAMILY SSF49464 26 107 1.03E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04215 29d8a2de1f30a9549c399e5bbab0014d 266 Pfam PF01695 IstB-like ATP binding protein 52 228 1.3E-60 T 21-04-2016 IPR002611 IstB-like ATP-binding protein GO:0005524 SPH21_RS04215 29d8a2de1f30a9549c399e5bbab0014d 266 SMART SM00382 97 230 0.0033 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS04215 29d8a2de1f30a9549c399e5bbab0014d 266 PANTHER PTHR30050 1 246 2.9E-61 T 21-04-2016 SPH21_RS04215 29d8a2de1f30a9549c399e5bbab0014d 266 SUPERFAMILY SSF52540 90 237 7.11E-22 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04215 29d8a2de1f30a9549c399e5bbab0014d 266 PANTHER PTHR30050:SF6 1 246 2.9E-61 T 21-04-2016 SPH21_RS04215 29d8a2de1f30a9549c399e5bbab0014d 266 Gene3D G3DSA:3.40.50.300 65 224 1.2E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04215 29d8a2de1f30a9549c399e5bbab0014d 266 PIRSF PIRSF003073 1 251 3.4E-74 T 21-04-2016 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SPH21_RS21870 29d8a2de1f30a9549c399e5bbab0014d 266 Pfam PF01695 IstB-like ATP binding protein 52 228 1.3E-60 T 21-04-2016 IPR002611 IstB-like ATP-binding protein GO:0005524 SPH21_RS21870 29d8a2de1f30a9549c399e5bbab0014d 266 SMART SM00382 97 230 0.0033 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS21870 29d8a2de1f30a9549c399e5bbab0014d 266 PANTHER PTHR30050 1 246 2.9E-61 T 21-04-2016 SPH21_RS21870 29d8a2de1f30a9549c399e5bbab0014d 266 SUPERFAMILY SSF52540 90 237 7.11E-22 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21870 29d8a2de1f30a9549c399e5bbab0014d 266 PANTHER PTHR30050:SF6 1 246 2.9E-61 T 21-04-2016 SPH21_RS21870 29d8a2de1f30a9549c399e5bbab0014d 266 Gene3D G3DSA:3.40.50.300 65 224 1.2E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21870 29d8a2de1f30a9549c399e5bbab0014d 266 PIRSF PIRSF003073 1 251 3.4E-74 T 21-04-2016 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 396 842 3.5E-13 T 21-04-2016 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 Gene3D G3DSA:3.20.110.10 49 200 1.6E-12 T 21-04-2016 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 PANTHER PTHR11607 49 844 2.1E-31 T 21-04-2016 SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 66 195 6.1E-8 T 21-04-2016 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 Gene3D G3DSA:2.60.40.1180 390 496 2.4E-8 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 SUPERFAMILY SSF74650 385 846 2.2E-40 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 SUPERFAMILY SSF88713 47 201 5.34E-23 T 21-04-2016 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SPH21_RS21320 9fc7542821e8d41ff0eb0d2b841a4364 847 PANTHER PTHR11607:SF15 49 844 2.1E-31 T 21-04-2016 SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 Gene3D G3DSA:3.60.10.10 105 323 6.3E-19 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 116 369 1.3E-22 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 PANTHER PTHR14859 287 378 1.5E-18 T 21-04-2016 IPR027317 PGAP2-interacting protein SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 PANTHER PTHR14859 101 257 1.5E-18 T 21-04-2016 IPR027317 PGAP2-interacting protein SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 SUPERFAMILY SSF56219 102 247 1.44E-37 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 SUPERFAMILY SSF56219 281 378 1.44E-37 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 PANTHER PTHR14859:SF0 287 378 1.5E-18 T 21-04-2016 SPH21_RS07265 1e4e2b8febbb685267f54013a85bed85 378 PANTHER PTHR14859:SF0 101 257 1.5E-18 T 21-04-2016 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 PIRSF PIRSF039102 1 333 1.9E-84 T 21-04-2016 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 Pfam PF07478 D-ala D-ala ligase C-terminus 148 328 2.4E-48 T 21-04-2016 IPR011095 D-alanine--D-alanine ligase, C-terminal GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 ProSitePatterns PS00843 D-alanine--D-alanine ligase signature 1. 83 94 - T 21-04-2016 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 Gene3D G3DSA:3.30.470.20 106 123 1.8E-44 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 Gene3D G3DSA:3.30.470.20 201 331 1.8E-44 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 ProSitePatterns PS00844 D-alanine--D-alanine ligase signature 2. 272 301 - T 21-04-2016 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 Hamap MF_00047 D-alanine--D-alanine ligase [ddl]. 3 331 32.115 T 21-04-2016 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 SUPERFAMILY SSF56059 116 331 7.74E-44 T 21-04-2016 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 Gene3D G3DSA:3.40.50.20 2 104 4.5E-22 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 Pfam PF01820 D-ala D-ala ligase N-terminus 4 106 1.4E-19 T 21-04-2016 IPR011127 D-alanine--D-alanine ligase, N-terminal domain KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 PANTHER PTHR23132 1 333 6.5E-73 T 21-04-2016 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 SUPERFAMILY SSF52440 3 115 2.88E-27 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 Gene3D G3DSA:3.30.1490.20 132 200 3.5E-15 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS15300 31f3c76e8274f9f49cac6bfc125d3fef 333 TIGRFAM TIGR01205 D_ala_D_alaTIGR: D-alanine--D-alanine ligase 4 330 1.4E-84 T 21-04-2016 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 SMART SM00382 390 562 6.0E-13 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 Gene3D G3DSA:3.40.50.300 346 594 3.0E-72 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 Gene3D G3DSA:1.20.1560.10 17 328 1.0E-84 T 21-04-2016 SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 PANTHER PTHR24221 14 356 1.5E-222 T 21-04-2016 SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 PANTHER PTHR24221 380 603 1.5E-222 T 21-04-2016 SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 Pfam PF00664 ABC transporter transmembrane region 33 300 1.1E-50 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 SUPERFAMILY SSF52540 335 601 1.5E-85 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 Pfam PF00005 ABC transporter 381 530 1.7E-30 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 ProSitePatterns PS00211 ABC transporters family signature. 502 516 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS11960 877beee42c99228a7309ffa417705ec4 606 SUPERFAMILY SSF90123 17 329 1.57E-83 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 Pfam PF02767 DNA polymerase III beta subunit, central domain 130 243 3.8E-19 T 21-04-2016 IPR022637 DNA polymerase III, beta chain, central GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 PIRSF PIRSF000804 1 371 1.3E-104 T 21-04-2016 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 Pfam PF00712 DNA polymerase III beta subunit, N-terminal domain 1 120 2.1E-24 T 21-04-2016 IPR022634 DNA polymerase III, beta chain, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 PANTHER PTHR30478 2 372 8.4E-103 T 21-04-2016 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 SUPERFAMILY SSF55979 246 370 1.82E-29 T 21-04-2016 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 Gene3D G3DSA:3.10.150.10 123 248 2.3E-29 T 21-04-2016 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 Gene3D G3DSA:3.10.150.10 1 120 4.6E-27 T 21-04-2016 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 SMART SM00480 17 363 1.1E-85 T 21-04-2016 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 SUPERFAMILY SSF55979 1 117 1.51E-24 T 21-04-2016 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 Gene3D G3DSA:3.10.150.10 249 371 2.3E-31 T 21-04-2016 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 SUPERFAMILY SSF55979 128 244 5.76E-23 T 21-04-2016 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 TIGRFAM TIGR00663 dnan: DNA polymerase III, beta subunit 1 369 1.7E-82 T 21-04-2016 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS08485 aa7b582e7144370be4561f6e686aaf67 374 Pfam PF02768 DNA polymerase III beta subunit, C-terminal domain 246 367 3.1E-21 T 21-04-2016 IPR022635 DNA polymerase III, beta chain, C-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS16125 10955845853d3ef807cc2d3c322040e4 149 PANTHER PTHR11527:SF122 12 148 2.7E-39 T 21-04-2016 SPH21_RS16125 10955845853d3ef807cc2d3c322040e4 149 PANTHER PTHR11527 12 148 2.7E-39 T 21-04-2016 IPR031107 Small heat shock protein HSP20 SPH21_RS16125 10955845853d3ef807cc2d3c322040e4 149 SUPERFAMILY SSF49764 13 143 8.37E-37 T 21-04-2016 IPR008978 HSP20-like chaperone SPH21_RS16125 10955845853d3ef807cc2d3c322040e4 149 Pfam PF00011 Hsp20/alpha crystallin family 46 149 6.3E-26 T 21-04-2016 IPR002068 Alpha crystallin/Hsp20 domain SPH21_RS16125 10955845853d3ef807cc2d3c322040e4 149 Gene3D G3DSA:2.60.40.790 11 146 1.9E-39 T 21-04-2016 IPR008978 HSP20-like chaperone SPH21_RS20225 6333826f429b8501793d716530d990b2 414 TIGRFAM TIGR03150 fabF: beta-ketoacyl-acyl-carrier-protein synthase II 2 411 1.2E-175 T 21-04-2016 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 UniPathway: UPA00094 SPH21_RS20225 6333826f429b8501793d716530d990b2 414 PANTHER PTHR11712 1 412 1.7E-187 T 21-04-2016 SPH21_RS20225 6333826f429b8501793d716530d990b2 414 SMART SM00825 Beta-ketoacyl synthase 4 404 9.9E-15 T 21-04-2016 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SPH21_RS20225 6333826f429b8501793d716530d990b2 414 Gene3D G3DSA:3.40.47.10 262 413 4.8E-56 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS20225 6333826f429b8501793d716530d990b2 414 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 254 368 2.8E-37 T 21-04-2016 IPR014031 Beta-ketoacyl synthase, C-terminal SPH21_RS20225 6333826f429b8501793d716530d990b2 414 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 154 170 - T 21-04-2016 IPR018201 Beta-ketoacyl synthase, active site SPH21_RS20225 6333826f429b8501793d716530d990b2 414 SUPERFAMILY SSF53901 1 251 1.2E-75 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS20225 6333826f429b8501793d716530d990b2 414 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 246 5.0E-56 T 21-04-2016 IPR014030 Beta-ketoacyl synthase, N-terminal SPH21_RS20225 6333826f429b8501793d716530d990b2 414 Gene3D G3DSA:3.40.47.10 2 259 3.7E-75 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS20225 6333826f429b8501793d716530d990b2 414 SUPERFAMILY SSF53901 215 412 5.07E-70 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS20225 6333826f429b8501793d716530d990b2 414 PIRSF PIRSF000447 1 414 4.9E-166 T 21-04-2016 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 UniPathway: UPA00094 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 Gene3D G3DSA:1.10.1740.10 2 89 7.5E-17 T 21-04-2016 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 Pfam PF04542 Sigma-70 region 2 19 84 1.6E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 14 169 1.2E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 Pfam PF08281 Sigma-70, region 4 115 165 9.7E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 Gene3D G3DSA:1.10.10.10 106 169 2.0E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 PANTHER PTHR30173 2 169 1.2E-31 T 21-04-2016 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 SUPERFAMILY SSF88946 2 89 1.96E-15 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 SUPERFAMILY SSF88659 111 171 7.41E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 137 153 4.4E-6 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 153 165 4.4E-6 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS00965 5e65accd87bb1f03ec9223f11c105240 174 PANTHER PTHR30173:SF20 2 169 1.2E-31 T 21-04-2016 SPH21_RS23505 4c10d28a7bfe4af698b3ad143b7e849d 190 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 134 168 4.7E-10 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS23505 4c10d28a7bfe4af698b3ad143b7e849d 190 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 81 111 0.003 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS23505 4c10d28a7bfe4af698b3ad143b7e849d 190 PANTHER PTHR23416:SF58 10 190 5.8E-57 T 21-04-2016 SPH21_RS23505 4c10d28a7bfe4af698b3ad143b7e849d 190 Gene3D G3DSA:2.160.10.10 8 188 1.3E-56 T 21-04-2016 SPH21_RS23505 4c10d28a7bfe4af698b3ad143b7e849d 190 SUPERFAMILY SSF51161 8 188 1.52E-46 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS23505 4c10d28a7bfe4af698b3ad143b7e849d 190 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 143 171 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS23505 4c10d28a7bfe4af698b3ad143b7e849d 190 PANTHER PTHR23416 10 190 5.8E-57 T 21-04-2016 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 Pfam PF01207 Dihydrouridine synthase (Dus) 18 320 1.2E-82 T 21-04-2016 IPR001269 tRNA-dihydrouridine synthase GO:0008033|GO:0017150|GO:0050660|GO:0055114 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 ProSitePatterns PS01136 Uncharacterized protein family UPF0034 signature. 98 116 - T 21-04-2016 IPR018517 tRNA-dihydrouridine synthase, conserved site GO:0008033|GO:0017150|GO:0050660|GO:0055114 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 PIRSF PIRSF006621 5 330 3.8E-97 T 21-04-2016 IPR001269 tRNA-dihydrouridine synthase GO:0008033|GO:0017150|GO:0050660|GO:0055114 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 Gene3D G3DSA:1.10.1200.80 257 325 1.2E-21 T 21-04-2016 IPR024036 tRNA-dihydrouridine synthase, putative, C-terminal GO:0016491|GO:0055114 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 SUPERFAMILY SSF51395 15 322 1.1E-81 T 21-04-2016 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 TIGRFAM TIGR00737 nifR3_yhdG: putative TIM-barrel protein, nifR3 family 15 323 9.8E-99 T 21-04-2016 IPR004652 tRNA-dihydrouridine synthase, TIM-barrel, NifR3 GO:0008033|GO:0016491|GO:0050660|GO:0055114 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 PANTHER PTHR11082:SF25 15 326 2.2E-120 T 21-04-2016 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 Gene3D G3DSA:3.20.20.70 15 250 1.8E-76 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS06415 2d6b0a8866e2762455a135d1ffdbb12a 333 PANTHER PTHR11082 15 326 2.2E-120 T 21-04-2016 IPR001269 tRNA-dihydrouridine synthase GO:0008033|GO:0017150|GO:0050660|GO:0055114 SPH21_RS19805 26857d1266ef0513fa5fe7943a68cd9c 414 Pfam PF02687 FtsX-like permease family 295 407 3.8E-14 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS19805 26857d1266ef0513fa5fe7943a68cd9c 414 Pfam PF12704 MacB-like periplasmic core domain 25 252 3.7E-32 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS19805 26857d1266ef0513fa5fe7943a68cd9c 414 PANTHER PTHR30572 2 414 6.7E-56 T 21-04-2016 SPH21_RS12165 42fb929939c208e9978cf80e78d6d89f 200 SMART SM00935 11 192 3.0E-31 T 21-04-2016 IPR005632 Chaperone protein Skp GO:0051082 SPH21_RS12165 42fb929939c208e9978cf80e78d6d89f 200 Gene3D G3DSA:3.30.910.20 40 83 1.8E-15 T 21-04-2016 SPH21_RS12165 42fb929939c208e9978cf80e78d6d89f 200 Gene3D G3DSA:3.30.910.20 121 192 1.8E-15 T 21-04-2016 SPH21_RS12165 42fb929939c208e9978cf80e78d6d89f 200 PANTHER PTHR35089 40 198 2.0E-17 T 21-04-2016 SPH21_RS12165 42fb929939c208e9978cf80e78d6d89f 200 PANTHER PTHR35089:SF1 40 198 2.0E-17 T 21-04-2016 SPH21_RS12165 42fb929939c208e9978cf80e78d6d89f 200 SUPERFAMILY SSF111384 46 192 4.05E-22 T 21-04-2016 IPR024930 Skp domain SPH21_RS12165 42fb929939c208e9978cf80e78d6d89f 200 Pfam PF03938 Outer membrane protein (OmpH-like) 16 191 1.7E-32 T 21-04-2016 IPR005632 Chaperone protein Skp GO:0051082 SPH21_RS02660 a4c42d034613f367dc7824375ea02ff2 146 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 28 77 2.5E-19 T 21-04-2016 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS02660 a4c42d034613f367dc7824375ea02ff2 146 SUPERFAMILY SSF69118 10 144 2.75E-41 T 21-04-2016 IPR029032 AhpD-like SPH21_RS02660 a4c42d034613f367dc7824375ea02ff2 146 Pfam PF02627 Carboxymuconolactone decarboxylase family 12 94 7.7E-21 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS02660 a4c42d034613f367dc7824375ea02ff2 146 Gene3D G3DSA:1.20.1290.10 9 143 7.1E-48 T 21-04-2016 IPR029032 AhpD-like SPH21_RS19565 29ac3263bcccc6eeb4a3f0c7ebddcb73 378 SUPERFAMILY SSF51126 268 345 1.26E-7 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS19565 29ac3263bcccc6eeb4a3f0c7ebddcb73 378 SUPERFAMILY SSF51126 53 234 1.26E-7 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS19565 29ac3263bcccc6eeb4a3f0c7ebddcb73 378 PANTHER PTHR41339 6 315 3.9E-42 T 21-04-2016 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 PRINTS PR01036 Tetracycline resistance protein TetB signature 325 345 8.1E-5 T 21-04-2016 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 PRINTS PR01036 Tetracycline resistance protein TetB signature 13 37 8.1E-5 T 21-04-2016 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 PRINTS PR01036 Tetracycline resistance protein TetB signature 135 159 8.1E-5 T 21-04-2016 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 PANTHER PTHR23501:SF31 6 474 1.9E-101 T 21-04-2016 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 Pfam PF07690 Major Facilitator Superfamily 16 257 1.6E-32 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 Pfam PF07690 Major Facilitator Superfamily 285 465 5.2E-11 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 Gene3D G3DSA:1.20.1250.20 272 470 3.0E-12 T 21-04-2016 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 PANTHER PTHR23501 6 474 1.9E-101 T 21-04-2016 SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 SUPERFAMILY SSF103473 262 466 2.35E-59 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 SUPERFAMILY SSF103473 6 196 2.35E-59 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS15340 44eaa68c809e6f425c07154af8262765 477 Gene3D G3DSA:1.20.1250.20 11 195 3.0E-28 T 21-04-2016 SPH21_RS25125 9252ccafaad0956df3d06bb6105e5b9c 203 Gene3D G3DSA:2.30.110.10 1 201 1.5E-59 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS25125 9252ccafaad0956df3d06bb6105e5b9c 203 SUPERFAMILY SSF50475 13 186 3.29E-30 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS25125 9252ccafaad0956df3d06bb6105e5b9c 203 PANTHER PTHR35802 2 200 5.8E-46 T 21-04-2016 SPH21_RS25125 9252ccafaad0956df3d06bb6105e5b9c 203 PIRSF PIRSF010372 1 203 1.5E-59 T 21-04-2016 IPR007396 Transcriptional regulator PAI 2-type SPH21_RS25125 9252ccafaad0956df3d06bb6105e5b9c 203 Pfam PF04299 Putative FMN-binding domain 1 160 3.7E-48 T 21-04-2016 IPR007396 Transcriptional regulator PAI 2-type SPH21_RS25125 9252ccafaad0956df3d06bb6105e5b9c 203 PANTHER PTHR35802:SF1 2 200 5.8E-46 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Gene3D G3DSA:2.40.170.20 898 988 8.9E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Gene3D G3DSA:2.40.170.20 835 860 8.9E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Gene3D G3DSA:2.40.170.20 232 249 8.9E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Gene3D G3DSA:2.40.170.20 295 761 8.9E-53 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Gene3D G3DSA:2.60.40.1120 34 123 9.2E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532 779 987 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532 544 762 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532 481 507 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532 16 405 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 205 234 2.1E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Gene3D G3DSA:2.170.130.10 124 231 4.0E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532:SF57 779 987 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532:SF57 544 762 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532:SF57 481 507 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 PANTHER PTHR11532:SF57 16 405 9.7E-219 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 33 989 8.3E-216 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Pfam PF00593 TonB dependent receptor 588 987 4.2E-19 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 SUPERFAMILY SSF49464 33 113 1.7E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 SUPERFAMILY SSF56935 827 870 1.05E-90 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 SUPERFAMILY SSF56935 111 251 1.05E-90 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 SUPERFAMILY SSF56935 899 976 1.05E-90 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 SUPERFAMILY SSF56935 286 375 1.05E-90 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 SUPERFAMILY SSF56935 408 754 1.05E-90 T 21-04-2016 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Pfam PF07715 TonB-dependent Receptor Plug Domain 123 228 5.2E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04955 f4a654a06838d2f557afa7c9b96b8cc3 989 Pfam PF13715 CarboxypepD_reg-like domain 34 115 2.4E-16 T 21-04-2016 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 SUPERFAMILY SSF48452 221 345 2.66E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 Gene3D G3DSA:1.25.40.10 100 253 1.4E-20 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 SUPERFAMILY SSF48452 100 218 4.17E-14 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 Gene3D G3DSA:1.25.40.10 254 295 5.1E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 PANTHER PTHR10098 261 343 5.9E-17 T 21-04-2016 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 PANTHER PTHR10098 101 219 5.9E-17 T 21-04-2016 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 Gene3D G3DSA:1.25.40.10 296 347 1.5E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 Pfam PF13424 Tetratricopeptide repeat 118 182 3.2E-7 T 21-04-2016 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 Pfam PF13424 Tetratricopeptide repeat 282 344 2.0E-7 T 21-04-2016 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 SMART SM00028 118 151 25.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 SMART SM00028 158 195 60.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 SMART SM00028 280 313 25.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 SMART SM00028 239 272 86.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06695 26eaf5fb5320a2fb31a78c1b9ba2ac15 379 SMART SM00028 320 353 290.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05830 eb411f9afa5c0c1ec0bff178cbf79242 365 SMART SM00327 174 357 0.0013 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS05830 eb411f9afa5c0c1ec0bff178cbf79242 365 SUPERFAMILY SSF53300 177 342 1.49E-17 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS05830 eb411f9afa5c0c1ec0bff178cbf79242 365 Gene3D G3DSA:3.40.50.410 178 280 2.9E-5 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS21010 71909e8545001e4f59f830cd95f4b446 589 PANTHER PTHR18964 316 466 5.2E-14 T 21-04-2016 SPH21_RS21010 71909e8545001e4f59f830cd95f4b446 589 PANTHER PTHR18964 63 292 5.2E-14 T 21-04-2016 SPH21_RS21010 71909e8545001e4f59f830cd95f4b446 589 Gene3D G3DSA:2.60.120.10 234 474 7.7E-50 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS21010 71909e8545001e4f59f830cd95f4b446 589 PANTHER PTHR18964:SF114 316 466 5.2E-14 T 21-04-2016 SPH21_RS21010 71909e8545001e4f59f830cd95f4b446 589 PANTHER PTHR18964:SF114 63 292 5.2E-14 T 21-04-2016 SPH21_RS21010 71909e8545001e4f59f830cd95f4b446 589 SUPERFAMILY SSF51182 499 571 1.44E-64 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS21010 71909e8545001e4f59f830cd95f4b446 589 SUPERFAMILY SSF51182 235 472 1.44E-64 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 Gene3D G3DSA:2.60.120.260 357 494 5.0E-18 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 Gene3D G3DSA:2.115.10.20 41 340 9.6E-45 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 Pfam PF00754 F5/8 type C domain 364 478 7.0E-12 T 21-04-2016 IPR000421 Coagulation factor 5/8 C-terminal domain SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 Pfam PF04616 Glycosyl hydrolases family 43 60 328 2.0E-25 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 PANTHER PTHR22925 51 181 4.5E-20 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 PANTHER PTHR22925 197 327 4.5E-20 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 Gene3D G3DSA:2.60.40.10 498 585 3.8E-7 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 SUPERFAMILY SSF49265 499 582 2.62E-7 T 21-04-2016 IPR003961 Fibronectin type III GO:0005515 SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 SUPERFAMILY SSF49785 352 494 2.76E-19 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS07000 9576030b7e4016a3fd3d8e3a5bea5310 586 SUPERFAMILY SSF75005 40 339 4.97E-48 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 Pfam PF01842 ACT domain 6 69 7.9E-9 T 21-04-2016 IPR002912 ACT domain GO:0008152|GO:0016597 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 Gene3D G3DSA:3.30.70.1150 87 164 5.6E-11 T 21-04-2016 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 PANTHER PTHR30239 4 164 4.1E-25 T 21-04-2016 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 Pfam PF10369 Small subunit of acetolactate synthase 87 160 7.6E-15 T 21-04-2016 IPR019455 Acetolactate synthase, small subunit, C-terminal KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 TIGRFAM TIGR00119 acolac_sm: acetolactate synthase, small subunit 6 160 3.5E-26 T 21-04-2016 IPR004789 Acetolactate synthase, small subunit GO:0003984|GO:0009082 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 SUPERFAMILY SSF55021 5 78 4.2E-15 T 21-04-2016 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 SUPERFAMILY SSF55021 80 162 7.32E-13 T 21-04-2016 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 PANTHER PTHR30239:SF0 4 164 4.1E-25 T 21-04-2016 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 ProDom PD002844 SMALL SUBUNIT ACETOLACTATE SYNTHASE SYNTHASE TRANSFERASE ACID BIOSYNTHESIS III LYASE 7 75 7.0E-12 T 21-04-2016 SPH21_RS11265 c8e07b57bac754359cde2c4a3412b442 196 Gene3D G3DSA:3.30.70.260 5 79 4.0E-22 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532 590 807 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532 528 559 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532 824 1064 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532 235 454 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532 8 219 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532:SF57 590 807 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532:SF57 528 559 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532:SF57 824 1064 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532:SF57 235 454 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 PANTHER PTHR11532:SF57 8 219 1.7E-174 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 SUPERFAMILY SSF49464 44 125 2.49E-11 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Gene3D G3DSA:2.40.170.20 896 921 5.6E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Gene3D G3DSA:2.40.170.20 963 1066 5.6E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Gene3D G3DSA:2.40.170.20 359 821 5.6E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Gene3D G3DSA:2.40.170.20 270 290 5.6E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Pfam PF07715 TonB-dependent Receptor Plug Domain 136 268 1.2E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Gene3D G3DSA:2.170.130.10 127 269 1.9E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 244 274 3.1E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Pfam PF13715 CarboxypepD_reg-like domain 45 127 5.9E-12 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 Gene3D G3DSA:2.60.40.1120 45 126 1.2E-7 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 44 1066 5.2E-191 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 SUPERFAMILY SSF56935 123 290 5.95E-70 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 SUPERFAMILY SSF56935 350 799 5.95E-70 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 SUPERFAMILY SSF56935 978 1066 5.95E-70 T 21-04-2016 SPH21_RS13680 ab32c08e6badf0f85834e0f636f122ce 1066 SUPERFAMILY SSF56935 888 931 5.95E-70 T 21-04-2016 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 ProSitePatterns PS00397 Site-specific recombinases active site. 7 15 - T 21-04-2016 IPR006118 Recombinase, conserved site GO:0000150|GO:0006310 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 PANTHER PTHR30461:SF3 1 465 2.7E-40 T 21-04-2016 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 Pfam PF07508 Recombinase 179 265 5.4E-13 T 21-04-2016 IPR011109 DNA-binding recombinase domain GO:0000150|GO:0003677 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 Gene3D G3DSA:3.40.50.1390 4 134 7.9E-24 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 Pfam PF00239 Resolvase, N terminal domain 5 153 2.0E-26 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 PANTHER PTHR30461 1 465 2.7E-40 T 21-04-2016 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 SUPERFAMILY SSF53041 4 153 1.09E-27 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS01430 8e990a4a709ee0200fb74379d1904b53 519 SMART SM00857 4 153 7.7E-35 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 Gene3D G3DSA:3.20.20.80 152 520 1.3E-89 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 Pfam PF02806 Alpha amylase, C-terminal all-beta domain 537 634 8.1E-20 T 21-04-2016 IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: REACT_474 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 Hamap MF_00685 1,4-alpha-glucan branching enzyme GlgB [glgB]. 7 635 42.177 T 21-04-2016 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 TIGRFAM TIGR01515 branching_enzym: 1,4-alpha-glucan branching enzyme 15 633 9.0E-257 T 21-04-2016 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 SUPERFAMILY SSF81296 23 127 5.42E-28 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 Gene3D G3DSA:2.60.40.10 19 127 4.4E-31 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 Pfam PF00128 Alpha amylase, catalytic domain 179 252 1.4E-8 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 PANTHER PTHR10357 1 634 0.0 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 PANTHER PTHR10357:SF160 1 634 0.0 T 21-04-2016 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 30 114 3.5E-19 T 21-04-2016 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 SUPERFAMILY SSF51445 139 530 4.23E-112 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 Gene3D G3DSA:2.60.40.1180 532 634 2.7E-29 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 SMART SM00642 157 519 1.1E-7 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 PIRSF PIRSF000463 2 636 8.5E-267 T 21-04-2016 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS25290 b702bf466989e153a12dee374547b5bd 636 SUPERFAMILY SSF51011 532 634 3.24E-27 T 21-04-2016 SPH21_RS10525 768ea2c660532cbd37ab40d351820d46 150 Gene3D G3DSA:3.40.630.30 3 142 4.5E-21 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS10525 768ea2c660532cbd37ab40d351820d46 150 PANTHER PTHR23091:SF259 1 133 6.2E-12 T 21-04-2016 SPH21_RS10525 768ea2c660532cbd37ab40d351820d46 150 Pfam PF13673 Acetyltransferase (GNAT) domain 37 134 1.6E-11 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS10525 768ea2c660532cbd37ab40d351820d46 150 SUPERFAMILY SSF55729 1 133 1.54E-19 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS10525 768ea2c660532cbd37ab40d351820d46 150 PANTHER PTHR23091 1 133 6.2E-12 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Pfam PF00122 E1-E2 ATPase 296 517 5.7E-69 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00943 Copper-transporting ATPase signature 447 461 6.7E-14 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00943 Copper-transporting ATPase signature 509 524 6.7E-14 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00943 Copper-transporting ATPase signature 703 720 6.7E-14 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00943 Copper-transporting ATPase signature 237 256 6.7E-14 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00943 Copper-transporting ATPase signature 314 332 6.7E-14 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00943 Copper-transporting ATPase signature 799 813 6.7E-14 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00943 Copper-transporting ATPase signature 294 313 6.7E-14 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 296 805 9.2E-90 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 ProSitePatterns PS01047 Heavy-metal-associated domain. 7 35 - T 21-04-2016 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Gene3D G3DSA:3.40.1110.10 541 653 9.1E-20 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 SUPERFAMILY SSF81665 425 520 5.62E-17 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 SUPERFAMILY SSF81665 290 328 5.62E-17 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 SUPERFAMILY SSF81665 775 823 5.62E-17 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 TIGRFAM TIGR01512 ATPase-IB2_Cd: cadmium-translocating P-type ATPase 290 836 1.7E-121 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Gene3D G3DSA:3.30.70.100 1 61 1.1E-12 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 673 683 7.7E-26 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 749 761 7.7E-26 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 726 745 7.7E-26 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 374 388 7.7E-26 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 526 540 7.7E-26 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PANTHER PTHR24093 4 836 8.6E-232 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Gene3D G3DSA:2.70.150.10 266 425 8.3E-30 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Pfam PF00403 Heavy-metal-associated domain 6 61 1.7E-5 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 SUPERFAMILY SSF55008 3 61 6.81E-11 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 253 835 9.5E-191 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Pfam PF00702 haloacid dehalogenase-like hydrolase 522 740 4.1E-39 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 528 534 - T 21-04-2016 IPR018303 P-type ATPase, phosphorylation site SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 235 836 3.2E-178 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Gene3D G3DSA:3.40.50.1000 497 540 3.0E-52 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 Gene3D G3DSA:3.40.50.1000 654 795 3.0E-52 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 SUPERFAMILY SSF81653 327 424 1.57E-26 T 21-04-2016 SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 SUPERFAMILY SSF56784 583 833 8.25E-56 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 SUPERFAMILY SSF56784 524 544 8.25E-56 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS00505 0274485a20500b464ff74043ae4013f2 840 PANTHER PTHR24093:SF50 4 836 8.6E-232 T 21-04-2016 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 PIRSF PIRSF001365 1 303 6.7E-75 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 Pfam PF00701 Dihydrodipicolinate synthetase family 7 290 1.4E-61 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 PANTHER PTHR12128 1 292 4.2E-74 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 PRINTS PR00146 Dihydrodipicolinate synthase signature 133 150 2.9E-12 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 PRINTS PR00146 Dihydrodipicolinate synthase signature 39 60 2.9E-12 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 PRINTS PR00146 Dihydrodipicolinate synthase signature 76 94 2.9E-12 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 Gene3D G3DSA:3.20.20.70 1 296 4.3E-90 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 SMART SM01130 5 294 8.6E-86 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04860 252aa5fdb6c7486e66ae69fb9a0d24e2 309 SUPERFAMILY SSF51569 3 292 8.06E-82 T 21-04-2016 SPH21_RS06305 bae8b49af4b541cdfe5d973115c868dc 268 Pfam PF08021 Siderophore-interacting FAD-binding domain 11 123 6.3E-29 T 21-04-2016 IPR013113 FAD-binding 9, siderophore-interacting SPH21_RS06305 bae8b49af4b541cdfe5d973115c868dc 268 Pfam PF04954 Siderophore-interacting protein 136 252 2.6E-33 T 21-04-2016 IPR007037 Siderophore-interacting protein SPH21_RS06305 bae8b49af4b541cdfe5d973115c868dc 268 PANTHER PTHR30157:SF1 9 262 6.3E-65 T 21-04-2016 SPH21_RS06305 bae8b49af4b541cdfe5d973115c868dc 268 Gene3D G3DSA:3.40.50.80 135 267 1.8E-39 T 21-04-2016 SPH21_RS06305 bae8b49af4b541cdfe5d973115c868dc 268 PANTHER PTHR30157 9 262 6.3E-65 T 21-04-2016 SPH21_RS06305 bae8b49af4b541cdfe5d973115c868dc 268 SUPERFAMILY SSF63380 8 123 5.39E-6 T 21-04-2016 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SPH21_RS06305 bae8b49af4b541cdfe5d973115c868dc 268 Gene3D G3DSA:2.40.30.10 5 124 1.4E-26 T 21-04-2016 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 119 133 4.4E-52 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 264 279 4.4E-52 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 149 168 4.4E-52 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 239 255 4.4E-52 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 187 206 4.4E-52 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 294 313 4.4E-52 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 SUPERFAMILY SSF51569 2 318 6.59E-128 T 21-04-2016 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 Pfam PF00490 Delta-aminolevulinic acid dehydratase 3 317 6.3E-136 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 ProSitePatterns PS00169 Delta-aminolevulinic acid dehydratase active site. 239 251 - T 21-04-2016 IPR030656 Delta-aminolevulinic acid dehydratase, active site KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PIRSF PIRSF001415 1 321 1.8E-134 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 PANTHER PTHR11458 2 318 1.8E-162 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 SMART SM01004 1 320 1.6E-192 T 21-04-2016 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25580 0819b70de1885ce5547f31a360e3eee6 322 Gene3D G3DSA:3.20.20.70 2 318 2.8E-136 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 SMART SM00382 574 718 4.6E-13 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 SUPERFAMILY SSF52540 553 791 9.63E-74 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Pfam PF02954 Bacterial regulatory protein, Fis family 812 856 9.9E-6 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 578 591 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Gene3D G3DSA:3.30.450.40 357 525 9.8E-6 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Gene3D G3DSA:3.30.450.40 186 349 5.5E-5 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Gene3D G3DSA:3.30.450.40 10 177 8.7E-9 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Gene3D G3DSA:1.10.8.60 727 799 3.5E-22 T 21-04-2016 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 767 776 - T 21-04-2016 IPR025944 Sigma-54 interaction domain, conserved site SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Gene3D G3DSA:3.40.50.300 550 726 1.1E-61 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 SUPERFAMILY SSF55781 32 182 2.84E-11 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 PANTHER PTHR32071 521 866 2.9E-155 T 21-04-2016 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 SUPERFAMILY SSF55781 187 351 7.41E-7 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 640 655 - T 21-04-2016 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 SUPERFAMILY SSF46689 765 858 5.82E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Gene3D G3DSA:1.10.10.60 800 859 1.2E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 SUPERFAMILY SSF55781 391 527 5.4E-6 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24075 27c9ee1fd33f3a167f664504ebbe9c94 866 Pfam PF00158 Sigma-54 interaction domain 554 721 6.2E-72 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 SMART SM00245 150 339 2.5E-49 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 SUPERFAMILY SSF52096 171 335 8.62E-62 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 SUPERFAMILY SSF52096 13 96 8.62E-62 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 PANTHER PTHR32060:SF0 16 420 3.5E-85 T 21-04-2016 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 Pfam PF03572 Peptidase family S41 177 333 8.0E-47 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 SUPERFAMILY SSF50156 47 176 8.15E-18 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 Gene3D G3DSA:2.30.42.10 78 159 1.3E-19 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 TIGRFAM TIGR00225 prc: C-terminal processing peptidase 39 333 5.6E-79 T 21-04-2016 IPR004447 C-terminal-processing peptidase S41A GO:0006508|GO:0008236 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 Pfam PF00595 PDZ domain (Also known as DHR or GLGF) 77 145 7.5E-12 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 PANTHER PTHR32060 16 420 3.5E-85 T 21-04-2016 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 SMART SM00228 77 149 2.8E-13 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 Gene3D G3DSA:3.90.226.10 367 379 1.1E-58 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 Gene3D G3DSA:3.90.226.10 160 332 1.1E-58 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06875 6e752a137f4ae80f6ffd67b8d9a4fd85 557 Gene3D G3DSA:3.90.226.10 448 455 1.1E-58 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS25355 531f5c02463962b8e46483249b0e6b71 654 PANTHER PTHR11533 234 258 1.3E-18 T 21-04-2016 IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase GO:0006508 SPH21_RS25355 531f5c02463962b8e46483249b0e6b71 654 PANTHER PTHR11533 292 630 1.3E-18 T 21-04-2016 IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase GO:0006508 SPH21_RS25355 531f5c02463962b8e46483249b0e6b71 654 PANTHER PTHR11533:SF185 234 258 1.3E-18 T 21-04-2016 SPH21_RS25355 531f5c02463962b8e46483249b0e6b71 654 PANTHER PTHR11533:SF185 292 630 1.3E-18 T 21-04-2016 SPH21_RS25355 531f5c02463962b8e46483249b0e6b71 654 Pfam PF01433 Peptidase family M1 336 474 1.8E-6 T 21-04-2016 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SPH21_RS25355 531f5c02463962b8e46483249b0e6b71 654 SUPERFAMILY SSF55486 342 555 1.46E-33 T 21-04-2016 SPH21_RS25355 531f5c02463962b8e46483249b0e6b71 654 Gene3D G3DSA:1.10.390.10 430 555 7.9E-15 T 21-04-2016 SPH21_RS22245 91b3e7d2a381ed80e8489a8f293220d9 133 PANTHER PTHR33993:SF4 1 133 9.0E-32 T 21-04-2016 SPH21_RS22245 91b3e7d2a381ed80e8489a8f293220d9 133 SUPERFAMILY SSF54593 1 132 3.24E-13 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS22245 91b3e7d2a381ed80e8489a8f293220d9 133 PANTHER PTHR33993 1 133 9.0E-32 T 21-04-2016 SPH21_RS22245 91b3e7d2a381ed80e8489a8f293220d9 133 Gene3D G3DSA:3.10.180.10 6 132 2.5E-26 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 SUPERFAMILY SSF56645 24 265 2.88E-73 T 21-04-2016 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 380 399 - T 21-04-2016 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 PANTHER PTHR10909 18 438 4.6E-174 T 21-04-2016 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 Gene3D G3DSA:1.10.540.10 13 143 7.7E-33 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 255 419 8.0E-35 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 Gene3D G3DSA:1.20.140.10 242 424 1.4E-58 T 21-04-2016 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 33 143 3.0E-27 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 148 242 1.8E-24 T 21-04-2016 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 150 162 - T 21-04-2016 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 PANTHER PTHR10909:SF320 18 438 4.6E-174 T 21-04-2016 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 Gene3D G3DSA:2.40.110.10 147 241 2.6E-38 T 21-04-2016 SPH21_RS00095 28219b4645adbd54b27ec2bb67324989 597 SUPERFAMILY SSF47203 253 424 2.42E-42 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS04410 f3862d32e985b261f515e69be7ca7641 155 Pfam PF04120 Low affinity iron permease 8 134 2.5E-54 T 21-04-2016 IPR007251 Low affinity iron permease, Fet4 GO:0055085 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 Pfam PF00884 Sulfatase 50 473 1.7E-75 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342:SF199 22 156 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342:SF199 314 368 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342:SF199 175 288 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342:SF199 417 570 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 SUPERFAMILY SSF53649 49 572 2.36E-137 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 Gene3D G3DSA:3.30.1120.10 505 575 2.1E-22 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 ProSitePatterns PS00149 Sulfatases signature 2. 145 155 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342 22 156 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342 314 368 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342 175 288 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 PANTHER PTHR10342 417 570 7.7E-159 T 21-04-2016 SPH21_RS24925 07ca85cfcc81adb468a28bfb7386303f 577 Gene3D G3DSA:3.40.720.10 47 501 3.0E-119 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS13255 ab8aed85386ef62c53412693a9f28c77 398 Gene3D G3DSA:1.20.1250.20 16 184 2.6E-24 T 21-04-2016 SPH21_RS13255 ab8aed85386ef62c53412693a9f28c77 398 Pfam PF07690 Major Facilitator Superfamily 17 352 1.3E-34 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS13255 ab8aed85386ef62c53412693a9f28c77 398 SUPERFAMILY SSF103473 9 390 1.83E-47 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13255 ab8aed85386ef62c53412693a9f28c77 398 Gene3D G3DSA:1.20.1250.20 206 386 2.4E-7 T 21-04-2016 SPH21_RS13255 ab8aed85386ef62c53412693a9f28c77 398 PANTHER PTHR23502 7 389 1.4E-58 T 21-04-2016 SPH21_RS13255 ab8aed85386ef62c53412693a9f28c77 398 PANTHER PTHR23502:SF63 7 389 1.4E-58 T 21-04-2016 SPH21_RS23790 79aecae4c1385bf100b9a10a1bac0665 276 PANTHER PTHR40041:SF2 12 276 2.4E-25 T 21-04-2016 SPH21_RS23790 79aecae4c1385bf100b9a10a1bac0665 276 PANTHER PTHR40041 12 276 2.4E-25 T 21-04-2016 SPH21_RS23790 79aecae4c1385bf100b9a10a1bac0665 276 Pfam PF02517 CAAX protease self-immunity 171 264 1.5E-22 T 21-04-2016 IPR003675 CAAX amino terminal protease GO:0016020 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 Pfam PF14683 Polysaccharide lyase family 4, domain III 28 196 6.6E-17 T 21-04-2016 IPR029411 Rhamnogalacturonan lyase, domain III SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 SUPERFAMILY SSF49785 27 198 9.35E-7 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 Gene3D G3DSA:2.70.98.10 306 619 2.3E-76 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 Gene3D G3DSA:3.30.2080.10 897 1043 5.2E-52 T 21-04-2016 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 PANTHER PTHR12143 283 669 1.3E-102 T 21-04-2016 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 PANTHER PTHR12143 689 1050 1.3E-102 T 21-04-2016 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 PANTHER PTHR12143:SF22 283 669 1.3E-102 T 21-04-2016 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 PANTHER PTHR12143:SF22 689 1050 1.3E-102 T 21-04-2016 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 SUPERFAMILY SSF48208 568 1032 1.7E-17 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 Pfam PF07971 Glycosyl hydrolase family 92 532 1034 6.0E-133 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 Gene3D G3DSA:1.20.1050.60 646 731 2.9E-20 T 21-04-2016 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 Gene3D G3DSA:1.20.1610.10 744 896 9.1E-42 T 21-04-2016 SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 301 1038 1.3E-123 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS21005 ca81f981378881302816487c69f0e55b 1050 Gene3D G3DSA:2.60.120.260 26 190 1.2E-6 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 PRINTS PR00786 Neprilysin metalloprotease (M13) family signature 582 593 5.3E-23 T 21-04-2016 IPR018497 Peptidase M13, C-terminal domain GO:0004222|GO:0006508 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 PRINTS PR00786 Neprilysin metalloprotease (M13) family signature 490 502 5.3E-23 T 21-04-2016 IPR018497 Peptidase M13, C-terminal domain GO:0004222|GO:0006508 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 PRINTS PR00786 Neprilysin metalloprotease (M13) family signature 511 527 5.3E-23 T 21-04-2016 IPR018497 Peptidase M13, C-terminal domain GO:0004222|GO:0006508 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 PRINTS PR00786 Neprilysin metalloprotease (M13) family signature 472 484 5.3E-23 T 21-04-2016 IPR018497 Peptidase M13, C-terminal domain GO:0004222|GO:0006508 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 Gene3D G3DSA:3.40.390.10 471 684 8.5E-111 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 Gene3D G3DSA:3.40.390.10 312 431 8.5E-111 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 Pfam PF01431 Peptidase family M13 480 680 1.4E-72 T 21-04-2016 IPR018497 Peptidase M13, C-terminal domain GO:0004222|GO:0006508 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 SUPERFAMILY SSF55486 40 684 5.98E-212 T 21-04-2016 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 PANTHER PTHR11733 40 684 1.1E-204 T 21-04-2016 IPR000718 Peptidase M13 GO:0004222|GO:0006508 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 Pfam PF05649 Peptidase family M13 48 428 1.2E-101 T 21-04-2016 IPR008753 Peptidase M13, N-terminal domain GO:0006508 SPH21_RS22865 6ec317390bacccf85a8d1c89bd1e5dee 684 PANTHER PTHR11733:SF65 40 684 1.1E-204 T 21-04-2016 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 SUPERFAMILY SSF51215 29 90 5.1E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 Gene3D G3DSA:1.10.10.60 172 219 2.4E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 Gene3D G3DSA:2.60.120.280 29 132 4.0E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 SUPERFAMILY SSF46689 173 217 5.38E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 Pfam PF12833 Helix-turn-helix domain 193 267 1.9E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 PANTHER PTHR11019 28 274 3.4E-19 T 21-04-2016 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 SUPERFAMILY SSF46689 220 268 2.24E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 Gene3D G3DSA:1.10.10.60 220 268 1.3E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24605 10b13fd8b48a0e1181e39f199ff61e7e 282 SMART SM00342 183 266 4.1E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 Pfam PF01938 TRAM domain 413 476 3.0E-9 T 21-04-2016 IPR002792 TRAM domain SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 SUPERFAMILY SSF102114 169 409 9.42E-55 T 21-04-2016 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 Pfam PF04055 Radical SAM superfamily 179 357 1.8E-30 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 Pfam PF00919 Uncharacterized protein family UPF0004 32 131 1.2E-31 T 21-04-2016 IPR013848 Methylthiotransferase, N-terminal GO:0003824|GO:0009451|GO:0051539 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 Gene3D G3DSA:3.80.30.20 173 413 2.2E-77 T 21-04-2016 IPR023404 Radical SAM, alpha/beta horseshoe SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 PANTHER PTHR11918:SF43 3 476 2.4E-212 T 21-04-2016 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 Hamap MF_01864 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase [miaB]. 31 477 66.847 T 21-04-2016 IPR006463 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB GO:0005737|GO:0006400|GO:0016740|GO:0051539 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 SMART SM00729 175 399 9.0E-48 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 179 199 - T 21-04-2016 IPR020612 Methylthiotransferase, conserved site GO:0051539 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 32 473 2.9E-130 T 21-04-2016 IPR005839 Methylthiotransferase GO:0016740|GO:0043412|GO:0051539 SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 PANTHER PTHR11918 3 476 2.4E-212 T 21-04-2016 IPR023970 Methylthiotransferase/radical SAM-type protein SPH21_RS03685 8e605cd069546059d6f2672d81172f9d 477 TIGRFAM TIGR01574 miaB-methiolase: tRNA-i(6)A37 thiotransferase enzyme MiaB 32 476 9.7E-136 T 21-04-2016 SPH21_RS01650 23cd19ac245229fc3bdba05d326e0378 128 PANTHER PTHR11049 3 127 1.6E-64 T 21-04-2016 SPH21_RS01650 23cd19ac245229fc3bdba05d326e0378 128 PANTHER PTHR11049:SF8 3 127 1.6E-64 T 21-04-2016 SPH21_RS01650 23cd19ac245229fc3bdba05d326e0378 128 SUPERFAMILY SSF54637 8 126 2.78E-34 T 21-04-2016 IPR029069 HotDog domain SPH21_RS01650 23cd19ac245229fc3bdba05d326e0378 128 Pfam PF03061 Thioesterase superfamily 28 98 1.7E-16 T 21-04-2016 IPR006683 Thioesterase domain SPH21_RS01650 23cd19ac245229fc3bdba05d326e0378 128 Gene3D G3DSA:3.10.129.10 5 123 1.6E-40 T 21-04-2016 IPR029069 HotDog domain SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 PANTHER PTHR33238 1 217 3.0E-65 T 21-04-2016 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 PANTHER PTHR33238:SF1 1 217 3.0E-65 T 21-04-2016 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 Pfam PF02742 Iron dependent repressor, metal binding and dimerisation domain 66 134 1.9E-29 T 21-04-2016 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 SMART SM00529 27 126 2.4E-41 T 21-04-2016 IPR022689 Iron dependent repressor GO:0003700|GO:0006355|GO:0046914 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 Pfam PF04023 FeoA domain 147 218 9.4E-9 T 21-04-2016 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 SUPERFAMILY SSF47979 66 139 2.09E-26 T 21-04-2016 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 Pfam PF01325 Iron dependent repressor, N-terminal DNA binding domain 1 61 6.0E-15 T 21-04-2016 IPR022687 DTXR-type HTH domain GO:0003677 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 Gene3D G3DSA:1.10.60.10 76 139 6.8E-30 T 21-04-2016 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 SUPERFAMILY SSF46785 3 65 3.03E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 SUPERFAMILY SSF50037 148 218 6.64E-6 T 21-04-2016 IPR008988 Transcriptional repressor, C-terminal SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 Gene3D G3DSA:1.10.10.10 2 73 4.7E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01555 bfc583601ec78b4a937b9864f6853803 218 SMART SM00899 146 218 1.0E-4 T 21-04-2016 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 SPH21_RS22255 5e810e938055c30abf759d67af454236 528 SMART SM00387 431 525 0.0082 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS22255 5e810e938055c30abf759d67af454236 528 Gene3D G3DSA:3.30.565.10 407 523 4.4E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS22255 5e810e938055c30abf759d67af454236 528 Pfam PF00072 Response regulator receiver domain 43 154 4.7E-25 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22255 5e810e938055c30abf759d67af454236 528 SMART SM00448 41 153 1.3E-35 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22255 5e810e938055c30abf759d67af454236 528 SUPERFAMILY SSF55785 163 279 1.22E-8 T 21-04-2016 IPR000014 PAS domain SPH21_RS22255 5e810e938055c30abf759d67af454236 528 SUPERFAMILY SSF52172 41 170 1.71E-37 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS22255 5e810e938055c30abf759d67af454236 528 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 435 524 8.0E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS22255 5e810e938055c30abf759d67af454236 528 Pfam PF07730 Histidine kinase 327 393 7.8E-9 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS22255 5e810e938055c30abf759d67af454236 528 Gene3D G3DSA:3.40.50.2300 40 166 4.8E-39 T 21-04-2016 SPH21_RS22255 5e810e938055c30abf759d67af454236 528 Gene3D G3DSA:3.30.450.20 167 290 2.8E-13 T 21-04-2016 SPH21_RS22255 5e810e938055c30abf759d67af454236 528 PANTHER PTHR24421 271 522 2.0E-37 T 21-04-2016 SPH21_RS22255 5e810e938055c30abf759d67af454236 528 SUPERFAMILY SSF55874 420 522 6.68E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS22255 5e810e938055c30abf759d67af454236 528 PANTHER PTHR24421:SF18 271 522 2.0E-37 T 21-04-2016 SPH21_RS24400 f2f6cc9bfb1f6c2f76b6472bf1842050 249 Pfam PF01695 IstB-like ATP binding protein 52 228 1.0E-60 T 21-04-2016 IPR002611 IstB-like ATP-binding protein GO:0005524 SPH21_RS24400 f2f6cc9bfb1f6c2f76b6472bf1842050 249 SMART SM00382 97 230 0.0033 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS24400 f2f6cc9bfb1f6c2f76b6472bf1842050 249 PANTHER PTHR30050 1 246 2.9E-61 T 21-04-2016 SPH21_RS24400 f2f6cc9bfb1f6c2f76b6472bf1842050 249 PANTHER PTHR30050:SF6 1 246 2.9E-61 T 21-04-2016 SPH21_RS24400 f2f6cc9bfb1f6c2f76b6472bf1842050 249 SUPERFAMILY SSF52540 92 237 7.31E-22 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24400 f2f6cc9bfb1f6c2f76b6472bf1842050 249 PIRSF PIRSF003073 1 249 8.6E-74 T 21-04-2016 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SPH21_RS24400 f2f6cc9bfb1f6c2f76b6472bf1842050 249 Gene3D G3DSA:3.40.50.300 65 224 1.0E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20670 f2f6cc9bfb1f6c2f76b6472bf1842050 249 Pfam PF01695 IstB-like ATP binding protein 52 228 1.0E-60 T 21-04-2016 IPR002611 IstB-like ATP-binding protein GO:0005524 SPH21_RS20670 f2f6cc9bfb1f6c2f76b6472bf1842050 249 SMART SM00382 97 230 0.0033 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS20670 f2f6cc9bfb1f6c2f76b6472bf1842050 249 PANTHER PTHR30050 1 246 2.9E-61 T 21-04-2016 SPH21_RS20670 f2f6cc9bfb1f6c2f76b6472bf1842050 249 PANTHER PTHR30050:SF6 1 246 2.9E-61 T 21-04-2016 SPH21_RS20670 f2f6cc9bfb1f6c2f76b6472bf1842050 249 SUPERFAMILY SSF52540 92 237 7.31E-22 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20670 f2f6cc9bfb1f6c2f76b6472bf1842050 249 PIRSF PIRSF003073 1 249 8.6E-74 T 21-04-2016 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SPH21_RS20670 f2f6cc9bfb1f6c2f76b6472bf1842050 249 Gene3D G3DSA:3.40.50.300 65 224 1.0E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 Gene3D G3DSA:1.10.1740.10 8 93 6.9E-17 T 21-04-2016 SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 PANTHER PTHR30173:SF20 8 190 3.4E-38 T 21-04-2016 SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 SUPERFAMILY SSF88946 9 90 1.0E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 SUPERFAMILY SSF88659 111 179 3.92E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 21 178 1.1E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 Pfam PF08281 Sigma-70, region 4 123 167 7.9E-12 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 PANTHER PTHR30173 8 190 3.4E-38 T 21-04-2016 SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 Gene3D G3DSA:1.10.10.10 115 180 2.4E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23690 bdfa8776e70093f7af6d2a1dd425f992 196 Pfam PF04542 Sigma-70 region 2 25 89 1.2E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04380 9ab3f75f7ba3e3b091db4aee0c937c06 529 Gene3D G3DSA:1.20.1250.20 21 197 4.1E-10 T 21-04-2016 SPH21_RS04380 9ab3f75f7ba3e3b091db4aee0c937c06 529 Pfam PF07690 Major Facilitator Superfamily 24 408 4.8E-15 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS04380 9ab3f75f7ba3e3b091db4aee0c937c06 529 PANTHER PTHR23501 12 422 1.0E-18 T 21-04-2016 SPH21_RS04380 9ab3f75f7ba3e3b091db4aee0c937c06 529 SUPERFAMILY SSF103473 257 422 2.01E-15 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS04380 9ab3f75f7ba3e3b091db4aee0c937c06 529 SUPERFAMILY SSF103473 11 201 2.01E-15 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS10170 de94b52457386e25bfde3a1214d92085 129 SMART SM00448 4 121 4.1E-14 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10170 de94b52457386e25bfde3a1214d92085 129 PANTHER PTHR26402 4 123 8.4E-21 T 21-04-2016 SPH21_RS10170 de94b52457386e25bfde3a1214d92085 129 Pfam PF00072 Response regulator receiver domain 6 117 3.5E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10170 de94b52457386e25bfde3a1214d92085 129 SUPERFAMILY SSF52172 4 126 1.57E-22 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10170 de94b52457386e25bfde3a1214d92085 129 Gene3D G3DSA:3.40.50.2300 2 127 1.4E-24 T 21-04-2016 SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 SMART SM00813 317 507 2.0E-74 T 21-04-2016 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55|UniPathway: UPA00667 SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 SUPERFAMILY SSF51011 385 513 3.13E-26 T 21-04-2016 SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 PANTHER PTHR31776:SF2 35 273 2.7E-223 T 21-04-2016 SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 PANTHER PTHR31776:SF2 303 513 2.7E-223 T 21-04-2016 SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 SUPERFAMILY SSF51445 36 399 1.09E-96 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 PANTHER PTHR31776 35 273 2.7E-223 T 21-04-2016 SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 PANTHER PTHR31776 303 513 2.7E-223 T 21-04-2016 SPH21_RS05040 efab94258bfcbbaaf4459f933f09605f 514 Pfam PF06964 Alpha-L-arabinofuranosidase C-terminal domain 317 507 1.4E-41 T 21-04-2016 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55|UniPathway: UPA00667 SPH21_RS11120 35385714ce7bd2c17b1f4dece86a61b2 127 SMART SM00448 1 120 1.5E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS11120 35385714ce7bd2c17b1f4dece86a61b2 127 PANTHER PTHR26402 1 123 4.3E-30 T 21-04-2016 SPH21_RS11120 35385714ce7bd2c17b1f4dece86a61b2 127 SUPERFAMILY SSF52172 1 124 7.83E-31 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS11120 35385714ce7bd2c17b1f4dece86a61b2 127 Gene3D G3DSA:3.40.50.2300 1 125 5.4E-32 T 21-04-2016 SPH21_RS11120 35385714ce7bd2c17b1f4dece86a61b2 127 Pfam PF00072 Response regulator receiver domain 3 120 7.3E-23 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 292 304 - T 21-04-2016 IPR018368 ClpA/B, conserved site 1 GO:0005524 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Gene3D G3DSA:3.40.50.300 754 782 3.1E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Gene3D G3DSA:3.40.50.300 548 721 3.1E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Gene3D G3DSA:3.40.50.300 157 340 5.0E-50 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Gene3D G3DSA:1.10.8.60 342 426 1.5E-36 T 21-04-2016 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 PANTHER PTHR11638:SF18 1 864 0.0 T 21-04-2016 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 TIGRFAM TIGR03346 chaperone_ClpB: ATP-dependent chaperone protein ClpB 6 860 0.0 T 21-04-2016 IPR017730 Chaperonin ClpB GO:0005737|GO:0009408|GO:0016485 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 PANTHER PTHR11638 1 864 0.0 T 21-04-2016 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 201 334 1.0E-13 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 771 850 8.9E-26 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 SUPERFAMILY SSF52540 544 861 8.2E-85 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Gene3D G3DSA:1.10.8.60 783 861 1.3E-30 T 21-04-2016 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Gene3D G3DSA:1.10.1780.10 1 145 7.0E-40 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Pfam PF07724 AAA domain (Cdc48 subfamily) 594 765 1.2E-54 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 599 617 1.4E-41 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 706 720 1.4E-41 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 644 662 1.4E-41 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 673 691 1.4E-41 T 21-04-2016 IPR001270 ClpA/B family GO:0005524 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 629 647 - T 21-04-2016 IPR028299 ClpA/B, conserved site 2 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 SUPERFAMILY SSF52540 155 543 1.12E-96 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 SMART SM00382 595 737 8.6E-13 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 SMART SM00382 196 341 1.1E-12 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 SUPERFAMILY SSF81923 4 153 1.96E-38 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 97 143 3.5E-10 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 17 68 3.1E-8 T 21-04-2016 IPR004176 Clp, N-terminal GO:0019538 SPH21_RS15680 216c1692f75a6460c0bc247b78e89b31 865 SMART SM01086 771 860 1.1E-36 T 21-04-2016 IPR019489 Clp ATPase, C-terminal SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Gene3D G3DSA:2.60.40.320 181 287 2.9E-23 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Gene3D G3DSA:2.70.98.10 738 842 5.0E-11 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Gene3D G3DSA:2.60.40.320 557 629 1.3E-6 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Gene3D G3DSA:3.20.20.80 288 546 6.6E-57 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 PANTHER PTHR10066 53 851 6.3E-139 T 21-04-2016 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 SUPERFAMILY SSF51445 286 544 4.7E-52 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Pfam PF00703 Glycosyl hydrolases family 2 218 289 1.0E-10 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 PRINTS PR00132 Glycosyl hydrolase family 2 signature 301 315 2.2E-8 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 PRINTS PR00132 Glycosyl hydrolase family 2 signature 332 350 2.2E-8 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 PANTHER PTHR10066:SF72 53 851 6.3E-139 T 21-04-2016 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 SUPERFAMILY SSF74650 675 848 1.13E-14 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 56 187 3.7E-20 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 291 510 1.5E-29 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 SUPERFAMILY SSF49785 6 190 1.03E-36 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 SUPERFAMILY SSF49303 208 289 1.15E-12 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Gene3D G3DSA:2.60.120.260 15 180 1.1E-37 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 Pfam PF02929 Beta galactosidase small chain 727 844 4.0E-9 T 21-04-2016 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11405 9477f12d0ff51af9535a33a2bcc1bc91 926 SUPERFAMILY SSF49303 558 628 1.2E-5 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS21800 25d414de4adab210bd9adf72371915c3 139 PANTHER PTHR33653:SF2 1 138 2.5E-28 T 21-04-2016 SPH21_RS21800 25d414de4adab210bd9adf72371915c3 139 SUPERFAMILY SSF88723 1 132 5.61E-29 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS21800 25d414de4adab210bd9adf72371915c3 139 Pfam PF01850 PIN domain 3 122 5.9E-12 T 21-04-2016 IPR002716 PIN domain SPH21_RS21800 25d414de4adab210bd9adf72371915c3 139 PANTHER PTHR33653 1 138 2.5E-28 T 21-04-2016 SPH21_RS21800 25d414de4adab210bd9adf72371915c3 139 Gene3D G3DSA:3.40.50.1010 1 132 5.4E-30 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS21800 25d414de4adab210bd9adf72371915c3 139 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC]. 3 129 11.117 T 21-04-2016 IPR022907 VapC family GO:0004540 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 Gene3D G3DSA:1.10.10.60 217 265 8.3E-17 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 Pfam PF12833 Helix-turn-helix domain 185 263 5.7E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 SUPERFAMILY SSF46689 217 264 3.4E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 246 262 1.8E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 231 246 1.8E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 PANTHER PTHR11019:SF45 27 269 1.9E-31 T 21-04-2016 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 SMART SM00342 179 262 7.8E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 Gene3D G3DSA:2.60.120.280 25 112 5.8E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 PANTHER PTHR11019 27 269 1.9E-31 T 21-04-2016 SPH21_RS09800 6f53dbfccc24eb682eb83d23af5a7adc 269 SUPERFAMILY SSF51215 25 81 4.97E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20135 bfcee988c7e1e66abd677117dab37edf 452 SUPERFAMILY SSF56954 3 441 6.8E-51 T 21-04-2016 SPH21_RS20135 bfcee988c7e1e66abd677117dab37edf 452 PANTHER PTHR30026 8 441 2.5E-27 T 21-04-2016 SPH21_RS20135 bfcee988c7e1e66abd677117dab37edf 452 PANTHER PTHR30026:SF4 8 441 2.5E-27 T 21-04-2016 SPH21_RS20135 bfcee988c7e1e66abd677117dab37edf 452 Pfam PF02321 Outer membrane efflux protein 14 220 2.3E-15 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS20135 bfcee988c7e1e66abd677117dab37edf 452 Pfam PF02321 Outer membrane efflux protein 248 433 2.1E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS20135 bfcee988c7e1e66abd677117dab37edf 452 Gene3D G3DSA:1.20.1600.10 9 440 1.8E-44 T 21-04-2016 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 PIRSF PIRSF001456 3 365 1.0E-149 T 21-04-2016 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 SUPERFAMILY SSF103263 4 362 1.27E-142 T 21-04-2016 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 ProSitePatterns PS00788 Chorismate synthase signature 2. 124 140 - T 21-04-2016 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 PANTHER PTHR21085 2 359 2.4E-209 T 21-04-2016 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 TIGRFAM TIGR00033 aroC: chorismate synthase 10 360 6.2E-142 T 21-04-2016 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 Gene3D G3DSA:3.60.150.10 10 361 8.9E-161 T 21-04-2016 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 ProSitePatterns PS00789 Chorismate synthase signature 3. 332 348 - T 21-04-2016 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 Pfam PF01264 Chorismate synthase 10 358 7.7E-148 T 21-04-2016 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 Hamap MF_00300 Chorismate synthase [aroC]. 10 365 37.708 T 21-04-2016 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS16025 871b3d444c0710bd2a5a9c938cb320ca 366 ProSitePatterns PS00787 Chorismate synthase signature 1. 16 31 - T 21-04-2016 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS23085 94f7cf4a242145ed3dd2c2e81bc4079a 191 Gene3D G3DSA:2.60.120.10 2 140 9.0E-36 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS23085 94f7cf4a242145ed3dd2c2e81bc4079a 191 PANTHER PTHR24567:SF33 11 190 1.7E-13 T 21-04-2016 SPH21_RS23085 94f7cf4a242145ed3dd2c2e81bc4079a 191 Pfam PF00027 Cyclic nucleotide-binding domain 30 116 6.1E-11 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS23085 94f7cf4a242145ed3dd2c2e81bc4079a 191 PANTHER PTHR24567 11 190 1.7E-13 T 21-04-2016 SPH21_RS23085 94f7cf4a242145ed3dd2c2e81bc4079a 191 SUPERFAMILY SSF51206 5 143 8.09E-22 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 251 273 4.2E-15 T 21-04-2016 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 105 123 4.2E-15 T 21-04-2016 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 9 28 4.2E-15 T 21-04-2016 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 170 188 4.2E-15 T 21-04-2016 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PANTHER PTHR22912:SF159 6 293 4.3E-74 T 21-04-2016 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 SUPERFAMILY SSF51905 1 299 6.68E-35 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 261 279 1.0E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 128 140 1.0E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 8 30 1.0E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 106 114 1.0E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 143 167 1.0E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 Gene3D G3DSA:3.50.50.60 250 301 7.5E-38 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 Gene3D G3DSA:3.50.50.60 6 130 7.5E-38 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 PANTHER PTHR22912 6 293 4.3E-74 T 21-04-2016 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 7 286 4.3E-30 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22775 3906a93a638ed6f387af7708c7591c83 303 Gene3D G3DSA:3.50.50.60 131 228 4.2E-33 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS05225 4d0e11bfc57cf055f719286ef92e042a 223 TIGRFAM TIGR00401 msrA: peptide-methionine (S)-S-oxide reductase 44 196 5.1E-62 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS05225 4d0e11bfc57cf055f719286ef92e042a 223 SUPERFAMILY SSF55068 41 207 3.14E-75 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS05225 4d0e11bfc57cf055f719286ef92e042a 223 PANTHER PTHR10173:SF6 42 196 2.5E-76 T 21-04-2016 SPH21_RS05225 4d0e11bfc57cf055f719286ef92e042a 223 PANTHER PTHR10173 42 196 2.5E-76 T 21-04-2016 IPR028427 Peptide methionine sulfoxide reductase GO:0006979|GO:0016671|GO:0030091 SPH21_RS05225 4d0e11bfc57cf055f719286ef92e042a 223 Hamap MF_01401 Peptide methionine sulfoxide reductase MsrA [msrA]. 42 201 36.888 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS05225 4d0e11bfc57cf055f719286ef92e042a 223 Pfam PF01625 Peptide methionine sulfoxide reductase 44 197 9.9E-65 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS05225 4d0e11bfc57cf055f719286ef92e042a 223 Gene3D G3DSA:3.30.1060.10 30 196 3.8E-73 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 ProSitePatterns PS00924 Aspartate and glutamate racemases signature 2. 186 196 - T 21-04-2016 IPR033134 Asp/Glu racemase, active site 2 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 ProSitePatterns PS00923 Aspartate and glutamate racemases signature 1. 68 76 - T 21-04-2016 IPR018187 Asp/Glu racemase, active site 1 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 Gene3D G3DSA:3.40.50.1860 3 177 3.2E-51 T 21-04-2016 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 SUPERFAMILY SSF53681 114 266 9.16E-35 T 21-04-2016 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 PANTHER PTHR21198:SF2 1 271 1.4E-87 T 21-04-2016 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 Pfam PF01177 Asp/Glu/Hydantoin racemase 4 221 6.0E-38 T 21-04-2016 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 Hamap MF_00258 Glutamate racemase [murI]. 2 263 31.101 T 21-04-2016 IPR004391 Glutamate racemase GO:0008881|GO:0009252 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 PANTHER PTHR21198 1 271 1.4E-87 T 21-04-2016 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 TIGRFAM TIGR00067 glut_race: glutamate racemase 4 256 7.5E-58 T 21-04-2016 IPR004391 Glutamate racemase GO:0008881|GO:0009252 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15720 e6f8c9d4c4d4402144143dd19cc63603 276 SUPERFAMILY SSF53681 3 106 1.67E-30 T 21-04-2016 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS13685 7a63d432a5044a28a7bc4516439b2343 516 Gene3D G3DSA:1.25.40.10 226 453 2.0E-26 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13685 7a63d432a5044a28a7bc4516439b2343 516 Pfam PF07980 SusD family 362 509 2.3E-25 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13685 7a63d432a5044a28a7bc4516439b2343 516 SUPERFAMILY SSF48452 23 509 3.89E-83 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13685 7a63d432a5044a28a7bc4516439b2343 516 Pfam PF14322 Starch-binding associating with outer membrane 113 208 4.3E-13 T 21-04-2016 SPH21_RS19790 a1b68b9b59bd36814686c43fdefbd578 380 PANTHER PTHR11751 1 379 8.8E-157 T 21-04-2016 SPH21_RS19790 a1b68b9b59bd36814686c43fdefbd578 380 Pfam PF00155 Aminotransferase class I and II 14 372 1.7E-74 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS19790 a1b68b9b59bd36814686c43fdefbd578 380 SUPERFAMILY SSF53383 3 377 1.29E-110 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS19790 a1b68b9b59bd36814686c43fdefbd578 380 PANTHER PTHR11751:SF306 1 379 8.8E-157 T 21-04-2016 SPH21_RS19790 a1b68b9b59bd36814686c43fdefbd578 380 Gene3D G3DSA:3.40.640.10 27 255 3.4E-75 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS19790 a1b68b9b59bd36814686c43fdefbd578 380 Gene3D G3DSA:3.90.1150.10 256 379 2.3E-37 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS19790 a1b68b9b59bd36814686c43fdefbd578 380 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216 229 - T 21-04-2016 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 Reactome: REACT_13 SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 SUPERFAMILY SSF52833 398 555 3.27E-31 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 PANTHER PTHR32234 49 387 4.8E-104 T 21-04-2016 SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 PANTHER PTHR32234 418 479 4.8E-104 T 21-04-2016 SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 PANTHER PTHR32234:SF0 49 387 4.8E-104 T 21-04-2016 IPR022910 Thiol:disulphide interchange protein DsbD GO:0047134|GO:0055114 SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 PANTHER PTHR32234:SF0 418 479 4.8E-104 T 21-04-2016 IPR022910 Thiol:disulphide interchange protein DsbD GO:0047134|GO:0055114 SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 Pfam PF13899 Thioredoxin-like 419 479 5.2E-11 T 21-04-2016 SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 Gene3D G3DSA:3.40.30.10 414 556 6.5E-44 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17945 4804f8ddcfb87f80aa96bfcb15d1bfcf 557 Pfam PF02683 Cytochrome C biogenesis protein transmembrane region 87 283 2.5E-14 T 21-04-2016 IPR003834 Cytochrome C biogenesis protein, transmembrane domain GO:0016020|GO:0017004|GO:0055114 SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 Gene3D G3DSA:3.40.50.300 654 740 1.8E-8 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 Gene3D G3DSA:3.40.50.300 905 1013 1.8E-8 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 Gene3D G3DSA:3.40.50.300 1 157 7.8E-17 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 Pfam PF13558 Putative exonuclease SbcCD, C subunit 903 976 1.4E-11 T 21-04-2016 SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 Pfam PF13476 AAA domain 5 275 2.7E-12 T 21-04-2016 SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 PANTHER PTHR32114 2 1020 2.0E-66 T 21-04-2016 IPR027050 Nuclease SbcCD subunit C GO:0004518|GO:0006281 SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 PANTHER PTHR32114:SF2 2 1020 2.0E-66 T 21-04-2016 SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 Gene3D G3DSA:1.10.287.510 459 551 6.6E-4 T 21-04-2016 SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 SUPERFAMILY SSF52540 911 1003 5.63E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19190 cbc206a4cd2160d9e593c869f999fe4e 1021 SUPERFAMILY SSF52540 9 183 5.63E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13580 55877aa9d06798225c17985727c49ff0 301 SUPERFAMILY SSF52402 180 299 4.02E-10 T 21-04-2016 SPH21_RS13580 55877aa9d06798225c17985727c49ff0 301 Gene3D G3DSA:3.40.50.620 26 165 5.7E-9 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS13580 55877aa9d06798225c17985727c49ff0 301 Pfam PF00582 Universal stress protein family 27 171 1.7E-5 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS13580 55877aa9d06798225c17985727c49ff0 301 Pfam PF00582 Universal stress protein family 248 299 2.0E-4 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS13580 55877aa9d06798225c17985727c49ff0 301 Gene3D G3DSA:3.40.50.620 166 299 1.0E-9 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS13580 55877aa9d06798225c17985727c49ff0 301 SUPERFAMILY SSF52402 26 172 1.26E-8 T 21-04-2016 SPH21_RS24295 0d23be2b1fb2052c4b8894b9573d507c 376 SUPERFAMILY SSF56024 76 134 5.93E-12 T 21-04-2016 SPH21_RS24295 0d23be2b1fb2052c4b8894b9573d507c 376 SMART SM00155 79 106 2.4E-4 T 21-04-2016 IPR001736 Phospholipase D/Transphosphatidylase GO:0003824 SPH21_RS24295 0d23be2b1fb2052c4b8894b9573d507c 376 Pfam PF13091 PLD-like domain 14 132 5.6E-14 T 21-04-2016 IPR025202 Phospholipase D-like domain SPH21_RS24295 0d23be2b1fb2052c4b8894b9573d507c 376 Gene3D G3DSA:3.30.870.10 76 149 1.2E-10 T 21-04-2016 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 PIRSF PIRSF000538 1 493 1.4E-92 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 PANTHER PTHR10196 2 487 4.9E-131 T 21-04-2016 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 SUPERFAMILY SSF53067 254 484 7.51E-34 T 21-04-2016 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 Gene3D G3DSA:3.30.420.40 2 246 3.0E-52 T 21-04-2016 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 3 246 7.6E-50 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 260 448 2.1E-8 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 Gene3D G3DSA:3.30.420.40 253 492 3.1E-26 T 21-04-2016 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 PANTHER PTHR10196:SF67 2 487 4.9E-131 T 21-04-2016 SPH21_RS19680 4eb6e78ec75ae671ab5bf6e09e72132b 493 SUPERFAMILY SSF53067 3 252 5.9E-54 T 21-04-2016 SPH21_RS18415 c8c5813d162c8f49721bebd2061da849 251 Pfam PF14064 HmuY protein 62 217 1.9E-7 T 21-04-2016 IPR025921 HmuY protein SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 SUPERFAMILY SSF53732 8 396 1.06E-209 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 SUPERFAMILY SSF53732 427 638 1.06E-209 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 Gene3D G3DSA:3.30.499.10 433 588 1.2E-57 T 21-04-2016 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 Gene3D G3DSA:3.30.499.10 347 371 1.2E-57 T 21-04-2016 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 TIGRFAM TIGR01341 aconitase_1: aconitate hydratase 1 7 905 0.0 T 21-04-2016 IPR006249 Aconitase/Iron-responsive element-binding protein 2 KEGG: 00020+4.2.1.3|KEGG: 00630+4.2.1.3|KEGG: 00720+4.2.1.3 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 Gene3D G3DSA:3.40.1060.10 228 345 6.2E-32 T 21-04-2016 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 ProSitePatterns PS00450 Aconitase family signature 1. 441 457 - T 21-04-2016 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 Gene3D G3DSA:3.20.19.10 652 904 1.3E-73 T 21-04-2016 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 Gene3D G3DSA:3.30.499.10 10 227 5.2E-80 T 21-04-2016 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 Pfam PF00330 Aconitase family (aconitate hydratase) 58 576 1.3E-167 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670 430 665 0.0 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670 764 907 0.0 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670 18 371 0.0 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670 681 726 0.0 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 181 194 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 445 456 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 128 141 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 350 364 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 271 284 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 195 210 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 507 520 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 257 270 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PRINTS PR00415 Aconitase family signature 152 160 1.6E-38 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670:SF1 430 665 0.0 T 21-04-2016 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670:SF1 764 907 0.0 T 21-04-2016 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670:SF1 18 371 0.0 T 21-04-2016 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 PANTHER PTHR11670:SF1 681 726 0.0 T 21-04-2016 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 Pfam PF00694 Aconitase C-terminal domain 706 831 1.3E-44 T 21-04-2016 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS00230 e51d761c86e1fb1bef4724019dda2a7a 907 SUPERFAMILY SSF52016 646 905 4.32E-83 T 21-04-2016 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SPH21_RS16570 16f9a6ea02867bbf2ee2b163ea33f870 274 Gene3D G3DSA:2.120.10.30 16 272 1.1E-22 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS16570 16f9a6ea02867bbf2ee2b163ea33f870 274 SUPERFAMILY SSF63829 9 272 2.4E-26 T 21-04-2016 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 Gene3D G3DSA:1.10.10.60 239 281 1.9E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 SUPERFAMILY SSF51215 38 168 1.96E-9 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 Gene3D G3DSA:2.60.120.280 36 168 2.0E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 SMART SM00342 199 282 2.8E-9 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 Pfam PF12833 Helix-turn-helix domain 205 282 6.9E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 PANTHER PTHR11019:SF45 38 290 3.0E-21 T 21-04-2016 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 PANTHER PTHR11019 38 290 3.0E-21 T 21-04-2016 SPH21_RS17905 c028d16f76474d71bfc60bf3bb60e07e 292 SUPERFAMILY SSF46689 235 282 1.84E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SUPERFAMILY SSF47384 446 523 4.12E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 PANTHER PTHR24423 321 676 1.5E-103 T 21-04-2016 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 PANTHER PTHR24423 39 160 1.5E-103 T 21-04-2016 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SUPERFAMILY SSF55781 187 336 1.45E-15 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SUPERFAMILY SSF55785 324 449 3.7E-31 T 21-04-2016 IPR000014 PAS domain SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Gene3D G3DSA:3.30.450.40 160 333 2.2E-17 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 566 675 7.8E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SMART SM00086 409 451 9.4E-9 T 21-04-2016 IPR001610 PAC motif SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 PRINTS PR00344 Bacterial sensor protein C-terminal signature 637 655 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 PRINTS PR00344 Bacterial sensor protein C-terminal signature 661 674 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 PRINTS PR00344 Bacterial sensor protein C-terminal signature 620 630 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 PRINTS PR00344 Bacterial sensor protein C-terminal signature 602 616 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Pfam PF08447 PAS fold 360 442 4.4E-19 T 21-04-2016 IPR013655 PAS fold-3 GO:0005515 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Gene3D G3DSA:1.10.287.130 449 507 2.8E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Gene3D G3DSA:3.30.450.20 334 448 2.8E-31 T 21-04-2016 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Pfam PF13185 GAF domain 184 320 2.1E-10 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Pfam PF13188 PAS domain 48 109 3.3E-5 T 21-04-2016 IPR000014 PAS domain SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Gene3D G3DSA:3.30.450.20 41 159 1.3E-8 T 21-04-2016 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 333 456 3.2E-25 T 21-04-2016 IPR000014 PAS domain SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Gene3D G3DSA:3.30.565.10 508 675 1.1E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 Pfam PF00512 His Kinase A (phospho-acceptor) domain 457 522 8.2E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SMART SM00388 457 522 3.4E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SMART SM00387 565 677 2.6E-35 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SMART SM00091 337 403 1.3E-11 T 21-04-2016 IPR000014 PAS domain SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SMART SM00065 184 333 6.9E-4 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS26215 db4952dd3f85d30fea308a2efba6a72d 677 SUPERFAMILY SSF55874 513 675 1.44E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15725 db927444f0fc82ff25945531de83d02b 547 PANTHER PTHR11938:SF50 156 486 2.9E-84 T 21-04-2016 SPH21_RS15725 db927444f0fc82ff25945531de83d02b 547 Pfam PF01645 Conserved region in glutamate synthase 153 471 3.0E-87 T 21-04-2016 IPR002932 Glutamate synthase domain GO:0006537|GO:0015930|GO:0016638|GO:0055114 SPH21_RS15725 db927444f0fc82ff25945531de83d02b 547 SUPERFAMILY SSF51395 8 495 4.29E-134 T 21-04-2016 SPH21_RS15725 db927444f0fc82ff25945531de83d02b 547 Gene3D G3DSA:3.20.20.70 45 492 9.6E-119 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15725 db927444f0fc82ff25945531de83d02b 547 PIRSF PIRSF006429 6 527 9.2E-158 T 21-04-2016 IPR024188 Glutamate synthase large subunit-like protein SPH21_RS15725 db927444f0fc82ff25945531de83d02b 547 PANTHER PTHR11938 156 486 2.9E-84 T 21-04-2016 SPH21_RS15725 db927444f0fc82ff25945531de83d02b 547 PIRSF PIRSF500060 6 526 5.7E-220 T 21-04-2016 IPR027283 Glutamate synthase large subunit-like protein, bacteria SPH21_RS14435 b5c244eaf772e2f694b521c1b3364c79 259 PANTHER PTHR23344 22 256 2.7E-40 T 21-04-2016 IPR004129 Glycerophosphoryl diester phosphodiesterase GO:0008889 SPH21_RS14435 b5c244eaf772e2f694b521c1b3364c79 259 SUPERFAMILY SSF51695 27 256 7.59E-48 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS14435 b5c244eaf772e2f694b521c1b3364c79 259 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 32 250 3.5E-24 T 21-04-2016 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SPH21_RS14435 b5c244eaf772e2f694b521c1b3364c79 259 Gene3D G3DSA:3.20.20.190 25 258 2.0E-48 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS13100 dc0052e75cec5e170807a69c6956946d 284 PANTHER PTHR11820:SF82 61 278 1.2E-64 T 21-04-2016 SPH21_RS13100 dc0052e75cec5e170807a69c6956946d 284 SUPERFAMILY SSF56529 62 279 1.57E-27 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS13100 dc0052e75cec5e170807a69c6956946d 284 Gene3D G3DSA:3.90.850.10 68 279 1.1E-25 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS13100 dc0052e75cec5e170807a69c6956946d 284 PANTHER PTHR11820 61 278 1.2E-64 T 21-04-2016 SPH21_RS13100 dc0052e75cec5e170807a69c6956946d 284 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 146 279 1.3E-13 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 SUPERFAMILY SSF51713 1 371 1.83E-148 T 21-04-2016 IPR002616 tRNA-guanine(15) transglycosylase-like GO:0006400|GO:0008479|GO:0008616 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 TIGRFAM TIGR00449 tgt_general: tRNA-guanine family transglycosylase 3 374 7.4E-143 T 21-04-2016 IPR002616 tRNA-guanine(15) transglycosylase-like GO:0006400|GO:0008479|GO:0008616 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 PANTHER PTHR21148 1 371 5.7E-150 T 21-04-2016 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 Gene3D G3DSA:3.20.20.105 1 372 1.7E-150 T 21-04-2016 IPR002616 tRNA-guanine(15) transglycosylase-like GO:0006400|GO:0008479|GO:0008616 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 Pfam PF01702 Queuine tRNA-ribosyltransferase 130 367 2.3E-81 T 21-04-2016 IPR002616 tRNA-guanine(15) transglycosylase-like GO:0006400|GO:0008479|GO:0008616 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 TIGRFAM TIGR00430 Q_tRNA_tgt: tRNA-guanine transglycosylase 3 374 2.2E-149 T 21-04-2016 IPR004803 Queuine tRNA-ribosyltransferase GO:0008033|GO:0008479|GO:0008616 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 PANTHER PTHR21148:SF26 1 371 5.7E-150 T 21-04-2016 SPH21_RS12500 16c63ef0148ea2e5390e4a5a8eda98b3 376 Hamap MF_00168 Queuine tRNA-ribosyltransferase [tgt]. 1 366 53.069 T 21-04-2016 IPR004803 Queuine tRNA-ribosyltransferase GO:0008033|GO:0008479|GO:0008616 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 SUPERFAMILY SSF53383 103 473 1.17E-77 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 PANTHER PTHR11751:SF314 122 473 1.7E-117 T 21-04-2016 SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 Gene3D G3DSA:1.10.10.10 11 75 2.4E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 SMART SM00345 15 74 1.4E-12 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 Gene3D G3DSA:3.40.640.10 148 366 3.8E-56 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 SUPERFAMILY SSF46785 11 84 3.98E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 Pfam PF00392 Bacterial regulatory proteins, gntR family 13 74 1.5E-13 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 Pfam PF00155 Aminotransferase class I and II 150 462 4.3E-27 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS22665 ea890d0e7527a1aa6a73737ad351b74b 478 PANTHER PTHR11751 122 473 1.7E-117 T 21-04-2016 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 Gene3D G3DSA:1.10.1740.10 4 108 6.2E-18 T 21-04-2016 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 179 7.5E-24 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 PANTHER PTHR30173 2 181 4.4E-25 T 21-04-2016 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 Pfam PF04542 Sigma-70 region 2 27 88 3.0E-8 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 SUPERFAMILY SSF88946 5 107 2.94E-17 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 SUPERFAMILY SSF88659 127 180 6.92E-14 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 Pfam PF04545 Sigma-70, region 4 130 178 2.5E-11 T 21-04-2016 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09500 240107a4b0591e648cc2eb119b6c03be 199 Gene3D G3DSA:1.10.10.10 122 181 5.3E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 SUPERFAMILY SSF49464 44 126 1.83E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 PANTHER PTHR11532:SF57 501 998 9.1E-206 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 PANTHER PTHR11532:SF57 42 361 9.1E-206 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 PANTHER PTHR11532:SF57 383 425 9.1E-206 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 SUPERFAMILY SSF56935 842 1000 1.1E-80 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 SUPERFAMILY SSF56935 124 266 1.1E-80 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 SUPERFAMILY SSF56935 299 388 1.1E-80 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 SUPERFAMILY SSF56935 428 774 1.1E-80 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Gene3D G3DSA:2.170.130.10 127 244 1.6E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Gene3D G3DSA:2.40.170.20 851 1000 6.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Gene3D G3DSA:2.40.170.20 286 387 6.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Gene3D G3DSA:2.40.170.20 423 791 6.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Gene3D G3DSA:2.40.170.20 245 254 6.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Gene3D G3DSA:2.60.40.1120 45 126 7.8E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 44 1000 7.1E-203 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Pfam PF07715 TonB-dependent Receptor Plug Domain 135 242 1.4E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 Pfam PF13715 CarboxypepD_reg-like domain 46 128 7.5E-19 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 218 248 2.5E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 PANTHER PTHR11532 501 998 9.1E-206 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 PANTHER PTHR11532 42 361 9.1E-206 T 21-04-2016 SPH21_RS09390 681f7e1c7711b4934a73fc6593e92670 1000 PANTHER PTHR11532 383 425 9.1E-206 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 Pfam PF00480 ROK family 91 390 2.8E-48 T 21-04-2016 IPR000600 ROK family SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 SUPERFAMILY SSF53067 80 391 6.48E-49 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 PANTHER PTHR18964:SF123 56 274 9.8E-60 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 PANTHER PTHR18964:SF123 303 393 9.8E-60 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 PANTHER PTHR18964 56 274 9.8E-60 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 PANTHER PTHR18964 303 393 9.8E-60 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 Gene3D G3DSA:3.30.420.40 217 373 4.9E-40 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 SUPERFAMILY SSF46785 13 74 7.93E-8 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 Gene3D G3DSA:3.30.420.40 77 216 4.1E-29 T 21-04-2016 SPH21_RS15585 e77b494eeb3e02fa3e8075ee6702542a 395 Gene3D G3DSA:1.10.10.10 9 75 1.4E-6 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10950 122a71a0d06e7be0489c68a84afd3b4f 136 PANTHER PTHR30558 1 134 4.1E-18 T 21-04-2016 SPH21_RS10950 122a71a0d06e7be0489c68a84afd3b4f 136 Pfam PF02472 Biopolymer transport protein ExbD/TolR 8 131 2.7E-23 T 21-04-2016 IPR003400 Biopolymer transport protein ExbD/TolR GO:0005215|GO:0006810|GO:0016020 SPH21_RS10335 a2f2ea3e57cd8a38d751fc2b7f2f8415 351 PANTHER PTHR34220 7 348 3.1E-52 T 21-04-2016 SPH21_RS10335 a2f2ea3e57cd8a38d751fc2b7f2f8415 351 Pfam PF06580 Histidine kinase 158 236 1.0E-23 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS10335 a2f2ea3e57cd8a38d751fc2b7f2f8415 351 Gene3D G3DSA:3.30.565.10 208 348 3.1E-13 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10335 a2f2ea3e57cd8a38d751fc2b7f2f8415 351 SUPERFAMILY SSF55874 220 347 3.7E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23420 1ca740961c8270a74852689615812c02 408 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 25 262 4.9E-23 T 21-04-2016 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SPH21_RS23420 1ca740961c8270a74852689615812c02 408 SUPERFAMILY SSF53649 22 317 9.74E-35 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS23420 1ca740961c8270a74852689615812c02 408 Gene3D G3DSA:3.40.720.10 19 319 7.6E-36 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS23420 1ca740961c8270a74852689615812c02 408 PANTHER PTHR10151 6 253 2.6E-13 T 21-04-2016 IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family SPH21_RS23420 1ca740961c8270a74852689615812c02 408 PANTHER PTHR10151:SF80 6 253 2.6E-13 T 21-04-2016 IPR029896 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 GO:0005886 SPH21_RS11310 6d198f5b1d5be7888f056ddc647a4da9 261 SUPERFAMILY SSF53955 89 255 5.62E-54 T 21-04-2016 IPR023346 Lysozyme-like domain SPH21_RS11310 6d198f5b1d5be7888f056ddc647a4da9 261 PANTHER PTHR30400 44 254 8.4E-81 T 21-04-2016 SPH21_RS11310 6d198f5b1d5be7888f056ddc647a4da9 261 Hamap MF_00766 Monofunctional biosynthetic peptidoglycan transglycosylase [mtgA]. 37 260 39.864 T 21-04-2016 IPR011812 Monofunctional biosynthetic peptidoglycan transglycosylase GO:0009252|GO:0009274|GO:0016021|GO:0016763 UniPathway: UPA00219 SPH21_RS11310 6d198f5b1d5be7888f056ddc647a4da9 261 TIGRFAM TIGR02070 mono_pep_trsgly: monofunctional biosynthetic peptidoglycan transglycosylase 43 259 3.8E-82 T 21-04-2016 IPR011812 Monofunctional biosynthetic peptidoglycan transglycosylase GO:0009252|GO:0009274|GO:0016021|GO:0016763 UniPathway: UPA00219 SPH21_RS11310 6d198f5b1d5be7888f056ddc647a4da9 261 Pfam PF00912 Transglycosylase 91 254 3.7E-46 T 21-04-2016 IPR001264 Glycosyl transferase, family 51 UniPathway: UPA00219 SPH21_RS11310 6d198f5b1d5be7888f056ddc647a4da9 261 Gene3D G3DSA:1.10.3810.10 89 255 3.6E-54 T 21-04-2016 SPH21_RS11310 6d198f5b1d5be7888f056ddc647a4da9 261 PANTHER PTHR30400:SF0 44 254 8.4E-81 T 21-04-2016 SPH21_RS22945 b431092f58d6b663fa50c005da8fb950 510 Pfam PF03349 Outer membrane protein transport protein (OMPP1/FadL/TodX) 34 443 1.1E-7 T 21-04-2016 IPR005017 Outer membrane protein transport protein (OMPP1/FadL/TodX) SPH21_RS22945 b431092f58d6b663fa50c005da8fb950 510 Gene3D G3DSA:2.40.160.60 36 158 1.8E-58 T 21-04-2016 SPH21_RS22945 b431092f58d6b663fa50c005da8fb950 510 Gene3D G3DSA:2.40.160.60 193 510 1.8E-58 T 21-04-2016 SPH21_RS22945 b431092f58d6b663fa50c005da8fb950 510 SUPERFAMILY SSF56935 35 138 2.75E-15 T 21-04-2016 SPH21_RS22945 b431092f58d6b663fa50c005da8fb950 510 SUPERFAMILY SSF56935 193 480 2.75E-15 T 21-04-2016 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 SUPERFAMILY SSF46977 424 521 3.79E-26 T 21-04-2016 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 Gene3D G3DSA:3.90.700.10 240 345 4.5E-37 T 21-04-2016 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 Gene3D G3DSA:3.50.50.60 3 239 3.1E-90 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 Gene3D G3DSA:3.50.50.60 346 405 3.1E-90 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 Pfam PF00890 FAD binding domain 5 389 1.5E-87 T 21-04-2016 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 SUPERFAMILY SSF51905 353 437 1.34E-59 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 SUPERFAMILY SSF51905 2 261 1.34E-59 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 Gene3D G3DSA:1.20.58.100 427 522 2.3E-26 T 21-04-2016 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 7.4E-6 T 21-04-2016 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 352 374 7.4E-6 T 21-04-2016 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 Pfam PF02910 Fumarate reductase flavoprotein C-term 439 519 1.0E-12 T 21-04-2016 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 PIRSF PIRSF000171 1 527 3.7E-34 T 21-04-2016 IPR030664 Succinate dehydrogenase/fumarate reductase, alpha/adenylylsulphate reductase subunit SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 PANTHER PTHR11632:SF27 3 522 1.2E-242 T 21-04-2016 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 PANTHER PTHR11632 3 522 1.2E-242 T 21-04-2016 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 SUPERFAMILY SSF56425 234 349 3.89E-40 T 21-04-2016 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 5 27 1.5E-5 T 21-04-2016 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 367 374 1.5E-5 T 21-04-2016 SPH21_RS06385 9972b23c8d852444d6b427f4a799973a 528 TIGRFAM TIGR00551 nadB: L-aspartate oxidase 4 517 8.6E-167 T 21-04-2016 IPR005288 L-aspartate oxidase GO:0005737|GO:0008734|GO:0009435|GO:0055114 KEGG: 00250+1.4.3.16|KEGG: 00760+1.4.3.16|MetaCyc: PWY-5316|MetaCyc: PWY-7342|UniPathway: UPA00253 SPH21_RS14385 6706557418cf00a7534dda2f9141730b 547 PANTHER PTHR30536:SF5 1 168 1.2E-137 T 21-04-2016 SPH21_RS14385 6706557418cf00a7534dda2f9141730b 547 PANTHER PTHR30536:SF5 194 547 1.2E-137 T 21-04-2016 SPH21_RS14385 6706557418cf00a7534dda2f9141730b 547 Pfam PF04295 D-galactarate dehydratase / Altronate hydrolase, C terminus 109 545 1.1E-154 T 21-04-2016 IPR007392 D-galactarate/Altronate dehydratase, C-terminal GO:0016829 SPH21_RS14385 6706557418cf00a7534dda2f9141730b 547 Pfam PF08666 SAF domain 12 82 4.7E-6 T 21-04-2016 IPR013974 SAF domain SPH21_RS14385 6706557418cf00a7534dda2f9141730b 547 SMART SM00858 12 83 8.9E-7 T 21-04-2016 IPR013974 SAF domain SPH21_RS14385 6706557418cf00a7534dda2f9141730b 547 PANTHER PTHR30536 1 168 1.2E-137 T 21-04-2016 SPH21_RS14385 6706557418cf00a7534dda2f9141730b 547 PANTHER PTHR30536 194 547 1.2E-137 T 21-04-2016 SPH21_RS18300 9c876378e42fa223f96c9639c93afa94 542 SUPERFAMILY SSF53720 22 508 8.9E-98 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS18300 9c876378e42fa223f96c9639c93afa94 542 Pfam PF00171 Aldehyde dehydrogenase family 63 506 1.0E-92 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS18300 9c876378e42fa223f96c9639c93afa94 542 Gene3D G3DSA:3.40.309.10 301 487 2.1E-42 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS18300 9c876378e42fa223f96c9639c93afa94 542 Gene3D G3DSA:3.40.605.10 31 300 1.4E-56 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS18300 9c876378e42fa223f96c9639c93afa94 542 PANTHER PTHR11699 9 542 1.8E-232 T 21-04-2016 SPH21_RS18300 9c876378e42fa223f96c9639c93afa94 542 PANTHER PTHR11699:SF69 9 542 1.8E-232 T 21-04-2016 SPH21_RS18300 9c876378e42fa223f96c9639c93afa94 542 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 314 325 - T 21-04-2016 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 Gene3D G3DSA:2.40.170.20 223 728 1.6E-37 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 SUPERFAMILY SSF56935 117 756 3.59E-65 T 21-04-2016 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 Gene3D G3DSA:2.60.40.1120 25 121 7.6E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 Pfam PF14905 Outer membrane protein beta-barrel family 391 793 2.0E-74 T 21-04-2016 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 Pfam PF07715 TonB-dependent Receptor Plug Domain 134 221 1.2E-7 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 SUPERFAMILY SSF49464 25 123 1.96E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 Pfam PF13715 CarboxypepD_reg-like domain 25 120 4.9E-15 T 21-04-2016 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 PANTHER PTHR32552:SF0 308 796 3.0E-13 T 21-04-2016 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 PANTHER PTHR32552:SF0 115 277 3.0E-13 T 21-04-2016 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 Gene3D G3DSA:2.170.130.10 122 222 1.0E-11 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 PANTHER PTHR32552 308 796 3.0E-13 T 21-04-2016 SPH21_RS13275 5e5d498a2a0aa5423278ad18964b0ad5 815 PANTHER PTHR32552 115 277 3.0E-13 T 21-04-2016 SPH21_RS08635 cd8fbb817fbd0a0c4b70976de5cfeb4c 399 Pfam PF13679 Methyltransferase domain 160 297 2.1E-32 T 21-04-2016 IPR025714 Methyltransferase domain SPH21_RS08635 cd8fbb817fbd0a0c4b70976de5cfeb4c 399 SUPERFAMILY SSF53335 167 294 3.97E-15 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS08635 cd8fbb817fbd0a0c4b70976de5cfeb4c 399 PANTHER PTHR13369 156 367 2.4E-30 T 21-04-2016 SPH21_RS08635 cd8fbb817fbd0a0c4b70976de5cfeb4c 399 Gene3D G3DSA:3.40.50.150 176 302 1.5E-9 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS00705 c24b138ddadfe131a6f33d96ba8f0ecf 146 PANTHER PTHR23404 33 146 1.2E-28 T 21-04-2016 SPH21_RS00705 c24b138ddadfe131a6f33d96ba8f0ecf 146 SUPERFAMILY SSF54690 19 144 4.71E-33 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS00705 c24b138ddadfe131a6f33d96ba8f0ecf 146 Pfam PF02391 MoaE protein 21 126 5.5E-27 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS00705 c24b138ddadfe131a6f33d96ba8f0ecf 146 Gene3D G3DSA:3.90.1170.40 21 145 1.1E-37 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS00705 c24b138ddadfe131a6f33d96ba8f0ecf 146 PANTHER PTHR23404:SF2 33 146 1.2E-28 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS06110 0b6adff3fda0249da6296cce58ed042a 324 PANTHER PTHR10516 178 306 3.3E-33 T 21-04-2016 IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type SPH21_RS06110 0b6adff3fda0249da6296cce58ed042a 324 Gene3D G3DSA:3.10.50.40 23 133 2.3E-6 T 21-04-2016 SPH21_RS06110 0b6adff3fda0249da6296cce58ed042a 324 SUPERFAMILY SSF54534 27 109 3.73E-8 T 21-04-2016 SPH21_RS06110 0b6adff3fda0249da6296cce58ed042a 324 SUPERFAMILY SSF54534 152 303 4.71E-35 T 21-04-2016 SPH21_RS06110 0b6adff3fda0249da6296cce58ed042a 324 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 198 299 1.8E-20 T 21-04-2016 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SPH21_RS06110 0b6adff3fda0249da6296cce58ed042a 324 Gene3D G3DSA:3.10.50.40 157 308 3.1E-40 T 21-04-2016 SPH21_RS08370 2358ff60bf3b73302ac4acec0526df6b 129 Pfam PF03061 Thioesterase superfamily 17 92 1.3E-12 T 21-04-2016 IPR006683 Thioesterase domain SPH21_RS08370 2358ff60bf3b73302ac4acec0526df6b 129 PANTHER PTHR11049:SF13 1 114 1.5E-58 T 21-04-2016 SPH21_RS08370 2358ff60bf3b73302ac4acec0526df6b 129 PANTHER PTHR11049 1 114 1.5E-58 T 21-04-2016 SPH21_RS08370 2358ff60bf3b73302ac4acec0526df6b 129 Gene3D G3DSA:3.10.129.10 3 118 1.7E-24 T 21-04-2016 IPR029069 HotDog domain SPH21_RS08370 2358ff60bf3b73302ac4acec0526df6b 129 SUPERFAMILY SSF54637 4 118 4.86E-25 T 21-04-2016 IPR029069 HotDog domain SPH21_RS24425 e332371d8534125d6bff070cb6b41984 169 ProDom PD034336 YITP MEMBRANE YVAW TRANSMEMBRANE 2 111 0.006 T 21-04-2016 IPR023902 Sporulation delaying protein SdpA SPH21_RS17715 f68343df56fb02ad933648e7e1638359 121 Pfam PF13676 TIR domain 5 101 6.7E-10 T 21-04-2016 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SPH21_RS17715 f68343df56fb02ad933648e7e1638359 121 SUPERFAMILY SSF52200 39 103 3.14E-7 T 21-04-2016 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SPH21_RS17715 f68343df56fb02ad933648e7e1638359 121 Gene3D G3DSA:3.40.50.9200 5 102 1.6E-7 T 21-04-2016 IPR015032 MTH538 TIR-like domain SPH21_RS15520 2af51a093c8308c973b64ead2b756ce2 200 Pfam PF13505 Outer membrane protein beta-barrel domain 7 167 7.2E-12 T 21-04-2016 IPR027385 Outer membrane protein beta-barrel SPH21_RS15520 2af51a093c8308c973b64ead2b756ce2 200 SUPERFAMILY SSF56925 23 200 7.59E-12 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS15520 2af51a093c8308c973b64ead2b756ce2 200 Gene3D G3DSA:2.40.160.20 23 183 6.6E-7 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PRINTS PR00132 Glycosyl hydrolase family 2 signature 410 425 2.0E-11 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PRINTS PR00132 Glycosyl hydrolase family 2 signature 328 346 2.0E-11 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PRINTS PR00132 Glycosyl hydrolase family 2 signature 297 311 2.0E-11 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PRINTS PR00132 Glycosyl hydrolase family 2 signature 104 119 2.0E-11 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Gene3D G3DSA:2.60.40.1560 620 697 1.1E-20 T 21-04-2016 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PANTHER PTHR10066 21 437 1.2E-162 T 21-04-2016 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PANTHER PTHR10066 471 737 1.2E-162 T 21-04-2016 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 292 483 1.0E-24 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 SUPERFAMILY SSF51445 290 434 6.67E-70 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 SUPERFAMILY SSF51445 463 593 6.67E-70 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PANTHER PTHR10066:SF71 21 437 1.2E-162 T 21-04-2016 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 PANTHER PTHR10066:SF71 471 737 1.2E-162 T 21-04-2016 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 SUPERFAMILY SSF49303 183 285 2.62E-18 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Pfam PF16355 Domain of unknown function (DUF4982) 625 685 8.8E-20 T 21-04-2016 IPR032311 Domain of unknown function DUF4982 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 SUPERFAMILY SSF49785 16 170 2.19E-45 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 25 171 1.9E-33 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Gene3D G3DSA:2.60.40.320 163 286 1.2E-31 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Gene3D G3DSA:2.60.120.260 19 162 5.8E-44 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Gene3D G3DSA:3.20.20.80 290 592 1.1E-76 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 Pfam PF00703 Glycosyl hydrolases family 2 184 285 3.3E-19 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS09750 15cd39c5b69abf55e73cc169bae02b5a 797 ProSitePatterns PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 410 424 - T 21-04-2016 IPR023232 Glycoside hydrolase, family 2, active site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 39 1017 3.2E-247 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 SUPERFAMILY SSF49464 39 129 4.58E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Pfam PF13715 CarboxypepD_reg-like domain 40 122 2.6E-16 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 SUPERFAMILY SSF56935 452 785 5.13E-94 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 SUPERFAMILY SSF56935 840 884 5.13E-94 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 SUPERFAMILY SSF56935 120 276 5.13E-94 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 SUPERFAMILY SSF56935 925 1016 5.13E-94 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 SUPERFAMILY SSF56935 334 422 5.13E-94 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 227 257 3.2E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532 576 1015 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532 1 388 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532 456 500 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532 522 554 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532:SF57 576 1015 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532:SF57 1 388 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532:SF57 456 500 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 PANTHER PTHR11532:SF57 522 554 2.4E-229 T 21-04-2016 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Gene3D G3DSA:2.170.130.10 126 252 6.5E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Gene3D G3DSA:2.40.170.20 343 794 9.7E-55 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Gene3D G3DSA:2.40.170.20 849 874 9.7E-55 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Gene3D G3DSA:2.40.170.20 911 1016 9.7E-55 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Gene3D G3DSA:2.40.170.20 253 276 9.7E-55 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Pfam PF07715 TonB-dependent Receptor Plug Domain 131 251 5.3E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23285 07613b58686b284db895b2e8ccb42574 1017 Gene3D G3DSA:2.60.40.1120 40 125 1.7E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 Gene3D G3DSA:2.40.100.10 3 135 1.3E-50 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 PANTHER PTHR11071 4 131 1.1E-45 T 21-04-2016 IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase GO:0003755|GO:0006457 SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 PIRSF PIRSF001467 1 145 4.3E-41 T 21-04-2016 IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase GO:0003755|GO:0006457 SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 83 98 1.4E-19 T 21-04-2016 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 43 55 1.4E-19 T 21-04-2016 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 17 32 1.4E-19 T 21-04-2016 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 113 128 1.4E-19 T 21-04-2016 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 Pfam PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 5 135 3.5E-43 T 21-04-2016 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 SUPERFAMILY SSF50891 3 143 3.36E-50 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS01690 bb1a6e255ee090832f32c29fb85e989b 145 ProSitePatterns PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 38 55 - T 21-04-2016 IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site GO:0003755|GO:0006457 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532 699 985 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532 165 451 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532 615 665 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532 494 559 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532 1002 1228 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532:SF57 699 985 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532:SF57 165 451 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532:SF57 615 665 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532:SF57 494 559 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 PANTHER PTHR11532:SF57 1002 1228 2.4E-176 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 SUPERFAMILY SSF49464 169 248 6.28E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Gene3D G3DSA:2.170.130.10 249 370 2.2E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 SMART SM00965 103 153 4.1E-5 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Pfam PF07715 TonB-dependent Receptor Plug Domain 258 366 8.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 SUPERFAMILY SSF56935 1066 1110 7.78E-83 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 SUPERFAMILY SSF56935 505 593 7.78E-83 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 SUPERFAMILY SSF56935 620 975 7.78E-83 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 SUPERFAMILY SSF56935 244 390 7.78E-83 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 SUPERFAMILY SSF56935 1149 1230 7.78E-83 T 21-04-2016 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 169 1230 2.5E-201 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Gene3D G3DSA:2.40.170.20 1159 1230 1.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Gene3D G3DSA:2.40.170.20 514 990 1.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Gene3D G3DSA:2.40.170.20 1075 1120 1.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Gene3D G3DSA:2.40.170.20 371 394 1.2E-39 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Gene3D G3DSA:2.60.40.1120 170 248 6.7E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 342 372 1.7E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04615 a8e84b90fd1a8d8679b7a4ea354a4d35 1230 Pfam PF13715 CarboxypepD_reg-like domain 170 250 5.0E-18 T 21-04-2016 SPH21_RS20555 4a9b68d384fe453120acd3177af8ec2f 322 Gene3D G3DSA:2.40.128.140 35 320 1.5E-55 T 21-04-2016 SPH21_RS20555 4a9b68d384fe453120acd3177af8ec2f 322 Pfam PF09982 Uncharacterized protein conserved in bacteria (DUF2219) 41 320 3.6E-57 T 21-04-2016 IPR018707 Protein of unknown function DUF2219 SPH21_RS01350 d43ec976d1bd1e3142a349584fe9bf08 187 Pfam PF12833 Helix-turn-helix domain 98 174 4.7E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS01350 d43ec976d1bd1e3142a349584fe9bf08 187 SUPERFAMILY SSF46689 128 174 1.88E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01350 d43ec976d1bd1e3142a349584fe9bf08 187 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 128 170 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS01350 d43ec976d1bd1e3142a349584fe9bf08 187 Gene3D G3DSA:1.10.10.60 130 179 4.3E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01350 d43ec976d1bd1e3142a349584fe9bf08 187 Gene3D G3DSA:3.30.70.100 3 63 3.5E-4 T 21-04-2016 SPH21_RS01350 d43ec976d1bd1e3142a349584fe9bf08 187 PANTHER PTHR11019 100 182 3.1E-18 T 21-04-2016 SPH21_RS01350 d43ec976d1bd1e3142a349584fe9bf08 187 SMART SM00342 91 174 3.9E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 PANTHER PTHR11732 1 295 1.2E-120 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 Gene3D G3DSA:3.20.20.100 3 291 2.0E-75 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 SUPERFAMILY SSF51430 3 290 3.14E-77 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 PANTHER PTHR11732:SF254 1 295 1.2E-120 T 21-04-2016 SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 PRINTS PR00069 Aldo-keto reductase signature 101 119 1.1E-5 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 PRINTS PR00069 Aldo-keto reductase signature 220 244 1.1E-5 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 PRINTS PR00069 Aldo-keto reductase signature 132 149 1.1E-5 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS19595 48678253c707d5ee286b04adb693bcc5 298 Pfam PF00248 Aldo/keto reductase family 13 285 1.2E-61 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 TIGRFAM TIGR02079 THD1: threonine dehydratase 26 429 1.2E-188 T 21-04-2016 IPR011820 L-threonine dehydratase biosynthetic IlvA GO:0004794 KEGG: 00260+4.3.1.19|KEGG: 00290+4.3.1.19|UniPathway: UPA00047 SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 Gene3D G3DSA:3.40.50.1100 112 354 2.4E-84 T 21-04-2016 SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 PANTHER PTHR10314 14 375 3.0E-166 T 21-04-2016 SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 32 323 4.2E-80 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 Pfam PF00585 C-terminal regulatory domain of Threonine dehydratase 336 428 3.7E-24 T 21-04-2016 IPR001721 ACT-like domain KEGG: 00260+4.3.1.19|KEGG: 00290+4.3.1.19|UniPathway: UPA00047 SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 SUPERFAMILY SSF55021 346 427 1.1E-9 T 21-04-2016 SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 59 72 - T 21-04-2016 IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site GO:0006520|GO:0030170 SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 PANTHER PTHR10314:SF30 14 375 3.0E-166 T 21-04-2016 SPH21_RS11220 6ba515ab79e8a950f3ece9291e462495 429 SUPERFAMILY SSF53686 19 372 1.57E-99 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS03385 f39e38d168668244dffac6481a78bacd 802 Gene3D G3DSA:2.60.40.1120 28 120 3.8E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03385 f39e38d168668244dffac6481a78bacd 802 Gene3D G3DSA:2.40.170.20 223 672 9.6E-27 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03385 f39e38d168668244dffac6481a78bacd 802 SUPERFAMILY SSF49464 28 123 1.04E-10 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03385 f39e38d168668244dffac6481a78bacd 802 SUPERFAMILY SSF56935 116 780 1.68E-46 T 21-04-2016 SPH21_RS03385 f39e38d168668244dffac6481a78bacd 802 Pfam PF14905 Outer membrane protein beta-barrel family 378 778 1.3E-83 T 21-04-2016 SPH21_RS03385 f39e38d168668244dffac6481a78bacd 802 Gene3D G3DSA:2.170.130.10 121 222 1.9E-8 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03385 f39e38d168668244dffac6481a78bacd 802 Pfam PF13715 CarboxypepD_reg-like domain 28 119 9.6E-13 T 21-04-2016 SPH21_RS14985 76ec3a5c77f6a24d9c83c8e4869c9241 117 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 6 111 3.5E-22 T 21-04-2016 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SPH21_RS14985 76ec3a5c77f6a24d9c83c8e4869c9241 117 PANTHER PTHR34583:SF2 1 117 3.6E-24 T 21-04-2016 SPH21_RS14985 76ec3a5c77f6a24d9c83c8e4869c9241 117 PANTHER PTHR34583 1 117 3.6E-24 T 21-04-2016 SPH21_RS12775 3369ae5968e9fa6e4c5c57f575e7a0c6 209 PANTHER PTHR30086:SF2 3 209 3.0E-63 T 21-04-2016 SPH21_RS12775 3369ae5968e9fa6e4c5c57f575e7a0c6 209 Pfam PF01810 LysE type translocator 15 205 1.1E-36 T 21-04-2016 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SPH21_RS12775 3369ae5968e9fa6e4c5c57f575e7a0c6 209 PANTHER PTHR30086 3 209 3.0E-63 T 21-04-2016 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SPH21_RS12775 3369ae5968e9fa6e4c5c57f575e7a0c6 209 PIRSF PIRSF006324 1 209 3.8E-55 T 21-04-2016 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 SUPERFAMILY SSF111337 1 349 1.15E-125 T 21-04-2016 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 PANTHER PTHR30307 2 349 2.7E-147 T 21-04-2016 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 Pfam PF02547 Queuosine biosynthesis protein 3 348 1.8E-136 T 21-04-2016 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 Hamap MF_00113 S-adenosylmethionine:tRNA ribosyltransferase-isomerase [queA]. 1 349 42.606 T 21-04-2016 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 PANTHER PTHR30307:SF0 2 349 2.7E-147 T 21-04-2016 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 Gene3D G3DSA:2.40.10.240 64 143 7.5E-21 T 21-04-2016 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 TIGRFAM TIGR00113 queA: S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1 349 5.3E-122 T 21-04-2016 IPR003699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA GO:0008616|GO:0016740|GO:0016853 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 Gene3D G3DSA:3.40.1780.10 186 349 1.6E-97 T 21-04-2016 SPH21_RS19810 5420d6f61e0702eb9dd0112f3cf6710d 349 Gene3D G3DSA:3.40.1780.10 1 62 1.6E-97 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF63829 180 384 3.27E-15 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SMART SM00342 1261 1344 4.3E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:1.10.287.130 823 890 4.0E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 942 1059 1.8E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1044 1057 4.7E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 985 999 4.7E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1020 1038 4.7E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1003 1013 4.7E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF55874 884 1058 3.8E-32 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Pfam PF00072 Response regulator receiver domain 1099 1209 8.4E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF47384 820 897 1.73E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:2.120.10.30 497 560 4.0E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:2.120.10.30 561 617 9.4E-8 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF63829 441 623 7.63E-18 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:3.30.565.10 896 1063 1.8E-33 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:2.120.10.30 362 464 1.8E-5 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:2.120.10.30 220 324 7.7E-8 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SMART SM00448 1097 1209 4.2E-34 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Pfam PF12833 Helix-turn-helix domain 1267 1343 3.6E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SMART SM00388 830 895 1.1E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SMART SM00387 941 1060 4.6E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:3.40.50.2300 1094 1220 1.8E-38 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF46689 1297 1344 2.82E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PANTHER PTHR24423 546 612 9.0E-94 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PANTHER PTHR24423 677 719 9.0E-94 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PANTHER PTHR24423 809 1253 9.0E-94 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF63829 366 388 7.63E-18 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF63829 26 194 7.85E-6 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:1.10.10.60 1239 1297 1.9E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 SUPERFAMILY SSF52172 1095 1221 4.98E-35 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Pfam PF07494 Two component regulator propeller 541 560 0.0056 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Pfam PF07494 Two component regulator propeller 581 603 4.4E-5 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PANTHER PTHR24423:SF486 546 612 9.0E-94 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PANTHER PTHR24423:SF486 677 719 9.0E-94 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 PANTHER PTHR24423:SF486 809 1253 9.0E-94 T 21-04-2016 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Gene3D G3DSA:1.10.10.60 1298 1343 1.4E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13115 81e4e04861ca47a32c0859818ea49931 1349 Pfam PF00512 His Kinase A (phospho-acceptor) domain 831 895 5.8E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 SUPERFAMILY SSF51338 28 86 5.32E-12 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 PANTHER PTHR22642:SF1 25 409 1.7E-93 T 21-04-2016 SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 Gene3D G3DSA:2.30.40.10 26 80 5.3E-6 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 PANTHER PTHR22642 25 409 1.7E-93 T 21-04-2016 SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 SUPERFAMILY SSF51556 71 365 4.74E-63 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 Gene3D G3DSA:3.20.20.140 81 363 5.0E-29 T 21-04-2016 SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 TIGRFAM TIGR01224 hutI: imidazolonepropionase 31 405 2.6E-103 T 21-04-2016 IPR005920 Imidazolonepropionase GO:0005737|GO:0016812|GO:0019556 KEGG: 00340+3.5.2.7|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16440 82f238de76d5ea519b6c565cf0feb25c 409 Pfam PF01979 Amidohydrolase family 68 406 3.1E-13 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 SUPERFAMILY SSF53474 25 307 6.08E-38 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PANTHER PTHR10992 172 307 6.5E-33 T 21-04-2016 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PANTHER PTHR10992 27 146 6.5E-33 T 21-04-2016 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 64 75 3.23E-8 T 21-04-2016 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 105 119 3.23E-8 T 21-04-2016 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 35 43 3.23E-8 T 21-04-2016 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 Pfam PF00561 alpha/beta hydrolase fold 34 292 1.4E-23 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 Gene3D G3DSA:3.40.50.1820 25 306 1.1E-37 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PRINTS PR00111 Alpha/beta hydrolase fold signature 61 76 5.39E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PRINTS PR00111 Alpha/beta hydrolase fold signature 105 118 5.39E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS20745 9b6f6ac467cdfb2775da61ab74aa877f 313 PRINTS PR00111 Alpha/beta hydrolase fold signature 119 132 5.39E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS07515 8e55216564ff29fb8e8a227070ce14d8 395 Gene3D G3DSA:3.40.710.10 46 370 2.2E-80 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS07515 8e55216564ff29fb8e8a227070ce14d8 395 SUPERFAMILY SSF56601 52 365 8.2E-81 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS07515 8e55216564ff29fb8e8a227070ce14d8 395 PANTHER PTHR22935 46 378 2.0E-71 T 21-04-2016 SPH21_RS07515 8e55216564ff29fb8e8a227070ce14d8 395 Pfam PF00144 Beta-lactamase 55 363 2.1E-57 T 21-04-2016 IPR001466 Beta-lactamase-related SPH21_RS16175 f316fc7337c3312419e2c20c073f0cba 293 Gene3D G3DSA:3.40.50.620 7 138 2.4E-5 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS16175 f316fc7337c3312419e2c20c073f0cba 293 Gene3D G3DSA:3.40.50.620 139 285 9.6E-16 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS16175 f316fc7337c3312419e2c20c073f0cba 293 SUPERFAMILY SSF52402 6 140 9.07E-6 T 21-04-2016 SPH21_RS16175 f316fc7337c3312419e2c20c073f0cba 293 SUPERFAMILY SSF52402 147 277 6.07E-16 T 21-04-2016 SPH21_RS16175 f316fc7337c3312419e2c20c073f0cba 293 Pfam PF00582 Universal stress protein family 148 276 2.1E-13 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 SUPERFAMILY SSF49464 124 219 2.88E-21 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 PANTHER PTHR11532:SF57 113 515 9.0E-267 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 PANTHER PTHR11532:SF57 598 1115 9.0E-267 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Pfam PF07715 TonB-dependent Receptor Plug Domain 218 325 1.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Pfam PF13715 CarboxypepD_reg-like domain 125 210 1.4E-19 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Gene3D G3DSA:2.170.130.10 219 328 8.4E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 124 1117 1.8E-270 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Gene3D G3DSA:2.60.40.1120 124 218 2.7E-21 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 302 331 1.2E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 SUPERFAMILY SSF56935 942 986 6.87E-100 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 SUPERFAMILY SSF56935 1022 1117 6.87E-100 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 SUPERFAMILY SSF56935 405 865 6.87E-100 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 SUPERFAMILY SSF56935 207 349 6.87E-100 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Gene3D G3DSA:2.40.170.20 951 976 4.0E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Gene3D G3DSA:2.40.170.20 1011 1117 4.0E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Gene3D G3DSA:2.40.170.20 329 348 4.0E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 Gene3D G3DSA:2.40.170.20 414 887 4.0E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 PANTHER PTHR11532 113 515 9.0E-267 T 21-04-2016 SPH21_RS12360 c8d155181d7fdac811c746232fff6928 1117 PANTHER PTHR11532 598 1115 9.0E-267 T 21-04-2016 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 SUPERFAMILY SSF51011 467 549 2.1E-14 T 21-04-2016 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 SUPERFAMILY SSF56112 849 1050 4.9E-12 T 21-04-2016 IPR011009 Protein kinase-like domain SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Pfam PF00128 Alpha amylase, catalytic domain 35 388 2.2E-78 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 TIGRFAM TIGR02457 TreS_Cterm: putative maltokinase 566 1102 4.0E-133 T 21-04-2016 IPR012811 Trehalose synthase/probable maltokinase, C-terminal domain SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Gene3D G3DSA:3.20.20.80 188 413 9.3E-107 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Gene3D G3DSA:3.20.20.80 446 459 9.3E-107 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Gene3D G3DSA:3.20.20.80 14 111 9.3E-107 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 PANTHER PTHR10357:SF164 443 576 7.9E-256 T 21-04-2016 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 PANTHER PTHR10357:SF164 6 404 7.9E-256 T 21-04-2016 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Gene3D G3DSA:2.60.40.1180 467 548 1.8E-13 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Gene3D G3DSA:3.90.1200.10 860 979 1.1E-5 T 21-04-2016 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Gene3D G3DSA:3.90.400.10 112 180 4.0E-23 T 21-04-2016 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 TIGRFAM TIGR02456 treS_nterm: trehalose synthase 11 547 2.7E-266 T 21-04-2016 IPR012810 Trehalose synthase/alpha-amylase, N-terminal GO:0003824|GO:0005975 KEGG: 00500+5.4.99.16|MetaCyc: PWY-2622 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 Pfam PF16657 Maltogenic Amylase, C-terminal domain 467 542 1.5E-21 T 21-04-2016 IPR032091 Maltogenic Amylase, C-terminal SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 SMART SM00642 20 419 3.0E-100 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 PANTHER PTHR10357 443 576 7.9E-256 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 PANTHER PTHR10357 6 404 7.9E-256 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 SUPERFAMILY SSF51445 10 330 8.39E-129 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS10730 3a50f9a415693126f392be76a43cf6c5 1105 SUPERFAMILY SSF51445 357 464 8.39E-129 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 Gene3D G3DSA:1.10.10.60 211 261 1.1E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 Gene3D G3DSA:2.60.120.10 19 90 1.3E-7 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 Pfam PF12833 Helix-turn-helix domain 181 258 1.1E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 SUPERFAMILY SSF46689 156 207 8.96E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 Pfam PF02311 AraC-like ligand binding domain 24 89 8.9E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 SUPERFAMILY SSF51182 17 88 8.45E-9 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 SUPERFAMILY SSF46689 210 260 9.41E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 Gene3D G3DSA:1.10.10.60 154 210 5.5E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 SMART SM00342 174 257 5.2E-25 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04360 490c6b8428d7c657c82d9487dcb1a982 273 PANTHER PTHR11019 18 265 9.0E-30 T 21-04-2016 SPH21_RS17615 6be9a4f7f8d2249407dc88808fb57d24 134 PANTHER PTHR14087 1 133 2.5E-57 T 21-04-2016 SPH21_RS17615 6be9a4f7f8d2249407dc88808fb57d24 134 Pfam PF01878 EVE domain 2 131 2.8E-48 T 21-04-2016 IPR002740 EVE domain SPH21_RS17615 6be9a4f7f8d2249407dc88808fb57d24 134 Gene3D G3DSA:3.10.590.10 1 132 1.0E-27 T 21-04-2016 IPR002740 EVE domain SPH21_RS17615 6be9a4f7f8d2249407dc88808fb57d24 134 SUPERFAMILY SSF88697 1 133 2.49E-51 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS20380 5754505f9aa4b2658b32f4c58ea2a754 239 Hamap MF_00801 Endonuclease V [nfi]. 12 224 32.435 T 21-04-2016 IPR007581 Endonuclease V GO:0004519|GO:0006281 SPH21_RS20380 5754505f9aa4b2658b32f4c58ea2a754 239 Pfam PF04493 Endonuclease V 22 214 1.7E-68 T 21-04-2016 IPR007581 Endonuclease V GO:0004519|GO:0006281 SPH21_RS20380 5754505f9aa4b2658b32f4c58ea2a754 239 PANTHER PTHR28511:SF1 12 233 5.4E-64 T 21-04-2016 SPH21_RS20380 5754505f9aa4b2658b32f4c58ea2a754 239 PANTHER PTHR28511 12 233 5.4E-64 T 21-04-2016 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 Gene3D G3DSA:3.40.50.1390 11 139 8.8E-25 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 ProSitePatterns PS00397 Site-specific recombinases active site. 12 20 - T 21-04-2016 IPR006118 Recombinase, conserved site GO:0000150|GO:0006310 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 SMART SM00857 9 158 1.0E-37 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 PANTHER PTHR30461 8 396 2.5E-38 T 21-04-2016 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 PANTHER PTHR30461:SF3 8 396 2.5E-38 T 21-04-2016 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 Pfam PF13408 Recombinase zinc beta ribbon domain 285 337 6.3E-7 T 21-04-2016 IPR025827 Recombinase zinc beta ribbon domain SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 SUPERFAMILY SSF53041 9 158 5.75E-30 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 Pfam PF00239 Resolvase, N terminal domain 11 158 3.2E-29 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS22830 5e1110dbb2e116a7406b34696705b7a6 494 Pfam PF07508 Recombinase 210 270 6.4E-11 T 21-04-2016 IPR011109 DNA-binding recombinase domain GO:0000150|GO:0003677 SPH21_RS15060 cf965331f87090f176e33bd186454692 401 Pfam PF00155 Aminotransferase class I and II 44 385 8.2E-57 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS15060 cf965331f87090f176e33bd186454692 401 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 240 249 - T 21-04-2016 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SPH21_RS15060 cf965331f87090f176e33bd186454692 401 SUPERFAMILY SSF53383 13 391 5.05E-111 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS15060 cf965331f87090f176e33bd186454692 401 Gene3D G3DSA:3.90.1150.10 278 387 4.8E-26 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS15060 cf965331f87090f176e33bd186454692 401 Gene3D G3DSA:3.40.640.10 61 277 1.5E-87 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS15060 cf965331f87090f176e33bd186454692 401 PANTHER PTHR13693 3 391 1.2E-151 T 21-04-2016 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 Gene3D G3DSA:3.20.20.60 7 76 5.6E-100 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 Gene3D G3DSA:3.20.20.60 172 328 5.6E-100 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 ProSitePatterns PS00110 Pyruvate kinase active site signature. 217 229 - T 21-04-2016 IPR018209 Pyruvate kinase, active site GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 SUPERFAMILY SSF52935 327 475 2.49E-31 T 21-04-2016 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 SUPERFAMILY SSF51621 2 78 1.08E-93 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 SUPERFAMILY SSF51621 159 340 1.08E-93 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 TIGRFAM TIGR01064 pyruv_kin: pyruvate kinase 6 475 5.4E-165 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 Pfam PF00224 Pyruvate kinase, barrel domain 6 338 1.5E-124 T 21-04-2016 IPR015793 Pyruvate kinase, barrel GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 Gene3D G3DSA:2.40.33.10 77 171 2.9E-30 T 21-04-2016 IPR015806 Pyruvate kinase, beta-barrel insert domain GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 Gene3D G3DSA:3.40.1380.20 329 472 1.9E-37 T 21-04-2016 IPR015794 Pyruvate kinase, alpha/beta GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 SUPERFAMILY SSF50800 74 170 9.77E-27 T 21-04-2016 IPR011037 Pyruvate kinase-like, insert domain SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PANTHER PTHR11817 7 475 6.0E-193 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PRINTS PR01050 Pyruvate kinase family signature 296 314 2.5E-67 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PRINTS PR01050 Pyruvate kinase family signature 271 295 2.5E-67 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PRINTS PR01050 Pyruvate kinase family signature 63 79 2.5E-67 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PRINTS PR01050 Pyruvate kinase family signature 246 270 2.5E-67 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PRINTS PR01050 Pyruvate kinase family signature 189 203 2.5E-67 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PRINTS PR01050 Pyruvate kinase family signature 219 245 2.5E-67 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 PRINTS PR01050 Pyruvate kinase family signature 315 331 2.5E-67 T 21-04-2016 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS06665 0b7c06cb490ebea727d01076d2b46df8 476 Pfam PF02887 Pyruvate kinase, alpha/beta domain 360 472 1.1E-27 T 21-04-2016 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 PANTHER PTHR12143 1 747 0.0 T 21-04-2016 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 Gene3D G3DSA:1.20.1050.60 336 425 7.3E-32 T 21-04-2016 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 Gene3D G3DSA:3.30.2080.10 589 733 2.0E-66 T 21-04-2016 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 PANTHER PTHR12143:SF22 1 747 0.0 T 21-04-2016 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 Gene3D G3DSA:1.20.1610.10 430 588 1.5E-58 T 21-04-2016 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 11 729 5.4E-236 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 SUPERFAMILY SSF48208 249 712 2.61E-30 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 Pfam PF07971 Glycosyl hydrolase family 92 227 724 1.9E-159 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS22530 0a5fab96676f184468cd51003de013c1 752 Gene3D G3DSA:2.70.98.10 12 309 4.7E-103 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS07780 210c92244e60e8f75413e923cd67103b 137 Gene3D G3DSA:3.30.428.10 3 130 2.8E-29 T 21-04-2016 IPR011146 HIT-like domain GO:0003824 SPH21_RS07780 210c92244e60e8f75413e923cd67103b 137 PANTHER PTHR23089 5 98 2.9E-29 T 21-04-2016 IPR001310 Histidine triad (HIT) protein SPH21_RS07780 210c92244e60e8f75413e923cd67103b 137 Pfam PF01230 HIT domain 11 100 5.2E-16 T 21-04-2016 IPR001310 Histidine triad (HIT) protein SPH21_RS07780 210c92244e60e8f75413e923cd67103b 137 SUPERFAMILY SSF54197 3 132 2.17E-34 T 21-04-2016 IPR011146 HIT-like domain GO:0003824 SPH21_RS07780 210c92244e60e8f75413e923cd67103b 137 PRINTS PR00332 Histidine triad family signature 4 20 4.6E-16 T 21-04-2016 IPR001310 Histidine triad (HIT) protein SPH21_RS07780 210c92244e60e8f75413e923cd67103b 137 PRINTS PR00332 Histidine triad family signature 25 43 4.6E-16 T 21-04-2016 IPR001310 Histidine triad (HIT) protein SPH21_RS07780 210c92244e60e8f75413e923cd67103b 137 PRINTS PR00332 Histidine triad family signature 87 97 4.6E-16 T 21-04-2016 IPR001310 Histidine triad (HIT) protein SPH21_RS18220 a36d37513d921307aae96706c849095c 219 SUPERFAMILY SSF51556 19 212 1.78E-38 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS18220 a36d37513d921307aae96706c849095c 219 Pfam PF01026 TatD related DNase 36 178 3.8E-34 T 21-04-2016 IPR001130 TatD family GO:0016788 SPH21_RS18220 a36d37513d921307aae96706c849095c 219 PANTHER PTHR10060 36 212 1.4E-33 T 21-04-2016 IPR001130 TatD family GO:0016788 SPH21_RS18220 a36d37513d921307aae96706c849095c 219 Gene3D G3DSA:3.20.20.140 35 212 1.4E-39 T 21-04-2016 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 PANTHER PTHR30069:SF2 2 445 3.2E-47 T 21-04-2016 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 Gene3D G3DSA:2.60.40.1120 27 107 3.9E-20 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 Gene3D G3DSA:2.170.130.10 108 228 4.6E-25 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 Pfam PF13715 CarboxypepD_reg-like domain 27 113 3.4E-20 T 21-04-2016 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 SUPERFAMILY SSF49464 27 116 7.06E-19 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 Pfam PF00593 TonB dependent receptor 541 787 1.8E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 Pfam PF07715 TonB-dependent Receptor Plug Domain 122 226 2.1E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 SUPERFAMILY SSF56935 110 787 4.27E-71 T 21-04-2016 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 PANTHER PTHR30069 2 445 3.2E-47 T 21-04-2016 SPH21_RS00895 864449448cc0544439c0da1789ddac75 794 Gene3D G3DSA:2.40.170.20 229 787 2.5E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 Pfam PF00072 Response regulator receiver domain 5 110 2.7E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 Pfam PF04397 LytTr DNA-binding domain 138 228 1.8E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 Gene3D G3DSA:2.40.50.40 130 196 1.8E-18 T 21-04-2016 SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 SUPERFAMILY SSF52172 1 118 1.85E-24 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 SMART SM00448 2 110 1.2E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 Gene3D G3DSA:3.40.50.2300 1 116 1.4E-22 T 21-04-2016 SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 SMART SM00850 137 230 5.2E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS22135 8beb28bf256ff11bd80a6bb66b3248b2 232 PANTHER PTHR26402 2 113 2.1E-25 T 21-04-2016 SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 Gene3D G3DSA:2.40.170.20 248 774 4.9E-80 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 PANTHER PTHR32552 120 775 1.4E-56 T 21-04-2016 SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 SUPERFAMILY SSF49464 42 121 4.58E-9 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 SUPERFAMILY SSF56935 113 774 3.4E-111 T 21-04-2016 SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 Gene3D G3DSA:2.60.40.1120 43 118 2.8E-6 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 Pfam PF00593 TonB dependent receptor 516 774 8.8E-34 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 Pfam PF07715 TonB-dependent Receptor Plug Domain 134 245 3.6E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS10410 f9062e5b60f377bcf7c6533b9d96b488 775 Gene3D G3DSA:2.170.130.10 119 247 1.4E-31 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19345 166f4c6795ac9fe0dee19deaab2001e3 284 SUPERFAMILY SSF53067 1 104 3.06E-27 T 21-04-2016 SPH21_RS19345 166f4c6795ac9fe0dee19deaab2001e3 284 PANTHER PTHR12862 1 264 1.3E-24 T 21-04-2016 SPH21_RS19345 166f4c6795ac9fe0dee19deaab2001e3 284 SUPERFAMILY SSF53067 108 279 6.48E-35 T 21-04-2016 SPH21_RS22760 e89322078751904699d256169a5e9521 196 Gene3D G3DSA:1.10.10.60 2 39 5.0E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22760 e89322078751904699d256169a5e9521 196 Pfam PF16925 Bacterial transcriptional repressor C-terminal 80 181 3.9E-9 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS22760 e89322078751904699d256169a5e9521 196 Gene3D G3DSA:1.10.10.60 40 57 5.8E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22760 e89322078751904699d256169a5e9521 196 PANTHER PTHR30055 4 193 1.1E-23 T 21-04-2016 SPH21_RS22760 e89322078751904699d256169a5e9521 196 ProSitePatterns PS01081 TetR-type HTH domain signature. 23 53 - T 21-04-2016 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SPH21_RS22760 e89322078751904699d256169a5e9521 196 SUPERFAMILY SSF46689 2 63 2.67E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22760 e89322078751904699d256169a5e9521 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 3.4E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS22760 e89322078751904699d256169a5e9521 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 3.4E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS22760 e89322078751904699d256169a5e9521 196 SUPERFAMILY SSF48498 79 192 1.38E-15 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS22760 e89322078751904699d256169a5e9521 196 Gene3D G3DSA:1.10.357.10 58 168 8.1E-15 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS22760 e89322078751904699d256169a5e9521 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 55 6.0E-13 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 PANTHER PTHR10516 133 165 1.9E-16 T 21-04-2016 IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 PANTHER PTHR10516 1 86 1.9E-16 T 21-04-2016 IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 PANTHER PTHR10516:SF316 133 165 1.9E-16 T 21-04-2016 SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 PANTHER PTHR10516:SF316 1 86 1.9E-16 T 21-04-2016 SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 SUPERFAMILY SSF54534 3 144 5.3E-27 T 21-04-2016 SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 Gene3D G3DSA:3.10.50.40 130 145 7.1E-13 T 21-04-2016 SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 Gene3D G3DSA:3.10.50.40 2 83 7.1E-13 T 21-04-2016 SPH21_RS17620 502907d3f1e3820353d735d1ff5963d6 165 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 3 141 8.2E-9 T 21-04-2016 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SPH21_RS02030 623854c5aba5453d865d61d44f5209bd 157 Pfam PF04308 Ribonuclease H-like 29 155 2.7E-36 T 21-04-2016 IPR007405 Bacteriophage KVP40, Orf299 SPH21_RS02030 623854c5aba5453d865d61d44f5209bd 157 PANTHER PTHR39961:SF1 31 157 4.9E-16 T 21-04-2016 SPH21_RS02030 623854c5aba5453d865d61d44f5209bd 157 PANTHER PTHR39961 31 157 4.9E-16 T 21-04-2016 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 9 245 1.6E-32 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 SUPERFAMILY SSF53067 253 481 2.59E-23 T 21-04-2016 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 357 440 2.3E-10 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 PANTHER PTHR10196 8 439 1.2E-57 T 21-04-2016 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 SUPERFAMILY SSF53067 9 245 1.38E-34 T 21-04-2016 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 Gene3D G3DSA:3.30.420.40 8 245 3.3E-32 T 21-04-2016 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 Gene3D G3DSA:3.30.420.40 254 479 4.9E-15 T 21-04-2016 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 PANTHER PTHR10196:SF9 8 439 1.2E-57 T 21-04-2016 SPH21_RS02140 702295e532d10178e55288947c97d38e 483 PIRSF PIRSF000538 6 483 6.6E-61 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS07595 0826873bf0ed1357fdf51de84445f373 320 PANTHER PTHR30213 2 313 1.6E-70 T 21-04-2016 SPH21_RS07595 0826873bf0ed1357fdf51de84445f373 320 Pfam PF03631 Virulence factor BrkB 25 293 1.4E-55 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS07595 0826873bf0ed1357fdf51de84445f373 320 PIRSF PIRSF035875 1 314 2.3E-67 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS07595 0826873bf0ed1357fdf51de84445f373 320 TIGRFAM TIGR00765 yihY_not_rbn: YihY family inner membrane protein 22 289 5.8E-25 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS07595 0826873bf0ed1357fdf51de84445f373 320 PANTHER PTHR30213:SF1 2 313 1.6E-70 T 21-04-2016 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 Pfam PF00773 RNB domain 257 584 8.7E-117 T 21-04-2016 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 Gene3D G3DSA:2.40.50.140 629 709 1.1E-17 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 PANTHER PTHR23355:SF9 79 711 3.6E-240 T 21-04-2016 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SUPERFAMILY SSF50249 68 144 8.58E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SMART SM00955 257 585 2.7E-161 T 21-04-2016 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SUPERFAMILY SSF50249 135 234 3.77E-22 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SMART SM00357 82 142 7.8E-4 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SMART SM00357 150 211 0.0035 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 Pfam PF08206 Ribonuclease B OB domain 83 141 4.0E-13 T 21-04-2016 IPR013223 Ribonuclease B, N-terminal OB domain SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 Pfam PF08206 Ribonuclease B OB domain 156 209 9.3E-8 T 21-04-2016 IPR013223 Ribonuclease B, N-terminal OB domain SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SUPERFAMILY SSF50249 629 709 1.78E-19 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 ProSitePatterns PS01175 Ribonuclease II family signature. 552 576 - T 21-04-2016 IPR022966 Ribonuclease II/R, conserved site SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 TIGRFAM TIGR00358 3_prime_RNase: VacB and RNase II family 3'-5' exoribonucleases 72 709 3.1E-168 T 21-04-2016 IPR004476 Ribonuclease II/ribonuclease R GO:0003723|GO:0004540|GO:0016070 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SMART SM00316 627 710 8.4E-10 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 Hamap MF_01895 Ribonuclease R [rnr]. 32 710 54.013 T 21-04-2016 IPR011805 Ribonuclease R GO:0003723|GO:0004518 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 Pfam PF00575 S1 RNA binding domain 626 708 1.0E-10 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 TIGRFAM TIGR02063 RNase_R: ribonuclease R 14 710 1.4E-232 T 21-04-2016 IPR011805 Ribonuclease R GO:0003723|GO:0004518 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 PANTHER PTHR23355 79 711 3.6E-240 T 21-04-2016 SPH21_RS15395 f0b5ce4bce4a7936a269b83feb799ccb 711 SUPERFAMILY SSF50249 218 626 8.0E-143 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS13785 87907fc457aa22bbc252aea1909a441a 142 Gene3D G3DSA:3.10.450.50 26 142 1.1E-28 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS13785 87907fc457aa22bbc252aea1909a441a 142 Pfam PF14534 Domain of unknown function (DUF4440) 27 134 4.6E-13 T 21-04-2016 IPR027843 Domain of unknown function DUF4440 SPH21_RS13785 87907fc457aa22bbc252aea1909a441a 142 SUPERFAMILY SSF54427 26 139 6.14E-19 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 Pfam PF13242 HAD-hyrolase-like 110 182 6.4E-16 T 21-04-2016 SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 TIGRFAM TIGR01662 HAD-SF-IIIA: HAD hydrolase, family IIIA 6 157 5.5E-33 T 21-04-2016 IPR006549 HAD-superfamily hydrolase,subfamily IIIA SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 SUPERFAMILY SSF56784 4 186 1.6E-43 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 Gene3D G3DSA:3.40.50.1000 3 184 1.1E-50 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 PIRSF PIRSF004682 1 191 1.6E-53 T 21-04-2016 IPR004446 D,D-heptose 1,7-bisphosphate phosphatase GO:0005975|GO:0016791 SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 TIGRFAM TIGR01656 Histidinol-ppas: histidinol-phosphate phosphatase domain 6 155 8.8E-38 T 21-04-2016 IPR006543 Histidinol-phosphate phosphatase GO:0016791 SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 PANTHER PTHR23133 1 188 7.8E-39 T 21-04-2016 SPH21_RS19030 9e01012882690dda90592e3140c59ce2 206 PANTHER PTHR23133:SF3 1 188 7.8E-39 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 Gene3D G3DSA:1.25.40.10 911 1099 1.5E-23 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 Gene3D G3DSA:1.25.40.10 750 847 1.5E-23 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 Gene3D G3DSA:1.25.40.10 541 739 1.7E-17 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SUPERFAMILY SSF48452 486 626 3.04E-14 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083:SF414 914 1045 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083:SF414 468 646 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083:SF414 681 835 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083:SF414 185 214 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SUPERFAMILY SSF48452 615 833 8.97E-17 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 Pfam PF13181 Tetratricopeptide repeat 1061 1092 0.16 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 Gene3D G3DSA:1.25.40.10 485 540 7.6E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 Pfam PF17128 Domain of unknown function (DUF5107) 41 344 9.1E-65 T 21-04-2016 IPR033396 Domain of unknown function DUF5107 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SMART SM00028 796 830 130.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SMART SM00028 1060 1093 0.68 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SMART SM00028 953 986 160.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SMART SM00028 762 795 0.016 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SMART SM00028 706 739 19.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SMART SM00028 606 639 140.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083 914 1045 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083 468 646 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083 681 835 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 PANTHER PTHR23083 185 214 9.3E-56 T 21-04-2016 SPH21_RS20600 1076f62935e328684a32f1db71731c6d 1116 SUPERFAMILY SSF48452 914 1094 6.45E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Pfam PF02954 Bacterial regulatory protein, Fis family 436 472 1.4E-4 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 PANTHER PTHR32071 1 477 7.5E-177 T 21-04-2016 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 SUPERFAMILY SSF52540 138 377 5.84E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Gene3D G3DSA:3.40.50.300 136 310 2.2E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 SUPERFAMILY SSF52172 1 183 6.69E-42 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Gene3D G3DSA:1.10.8.60 312 364 8.1E-20 T 21-04-2016 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 SMART SM00382 159 310 8.6E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 SMART SM00448 2 113 1.9E-32 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Pfam PF00158 Sigma-54 interaction domain 139 305 2.3E-67 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 SUPERFAMILY SSF46689 422 474 5.38E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 SUPERFAMILY SSF46689 352 395 5.38E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Gene3D G3DSA:3.40.50.2300 1 122 2.4E-36 T 21-04-2016 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Gene3D G3DSA:1.10.10.60 365 383 8.8E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Gene3D G3DSA:1.10.10.60 420 475 8.8E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16655 82a7431956f66cf81ed7b66fb5f90bc9 478 Pfam PF00072 Response regulator receiver domain 4 112 3.6E-28 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18655 0d4d5d6f03d8b5f4f3cb316369dc50a9 288 Gene3D G3DSA:1.20.1080.10 26 260 3.2E-65 T 21-04-2016 IPR023271 Aquaporin-like SPH21_RS18655 0d4d5d6f03d8b5f4f3cb316369dc50a9 288 PANTHER PTHR30520 1 272 8.8E-61 T 21-04-2016 SPH21_RS18655 0d4d5d6f03d8b5f4f3cb316369dc50a9 288 PANTHER PTHR30520:SF0 1 272 8.8E-61 T 21-04-2016 SPH21_RS18655 0d4d5d6f03d8b5f4f3cb316369dc50a9 288 Pfam PF01226 Formate/nitrite transporter 8 256 5.0E-64 T 21-04-2016 IPR000292 Formate/nitrite transporter GO:0005215|GO:0006810|GO:0016020 SPH21_RS19775 61c9340b5d80d819237d8cec0ecd6323 391 SUPERFAMILY SSF55326 18 165 2.97E-11 T 21-04-2016 SPH21_RS19775 61c9340b5d80d819237d8cec0ecd6323 391 PANTHER PTHR10520 252 371 9.1E-42 T 21-04-2016 SPH21_RS19775 61c9340b5d80d819237d8cec0ecd6323 391 PANTHER PTHR10520 34 234 9.1E-42 T 21-04-2016 SPH21_RS19775 61c9340b5d80d819237d8cec0ecd6323 391 Gene3D G3DSA:3.30.1330.10 33 172 7.6E-14 T 21-04-2016 IPR016188 PurM-like, N-terminal domain SPH21_RS19775 61c9340b5d80d819237d8cec0ecd6323 391 SUPERFAMILY SSF56042 175 380 3.98E-31 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS19775 61c9340b5d80d819237d8cec0ecd6323 391 Gene3D G3DSA:3.90.650.10 175 381 5.3E-42 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS19775 61c9340b5d80d819237d8cec0ecd6323 391 Pfam PF02769 AIR synthase related protein, C-terminal domain 180 381 2.4E-8 T 21-04-2016 IPR010918 AIR synthase-related protein, C-terminal domain SPH21_RS18875 da22282d065c317e02936d747409f37e 602 Pfam PF00128 Alpha amylase, catalytic domain 122 213 1.3E-16 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 PIRSF PIRSF006337 1 591 5.7E-202 T 21-04-2016 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902|UniPathway: UPA00299 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 PANTHER PTHR10357:SF110 3 307 1.3E-95 T 21-04-2016 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 PANTHER PTHR10357:SF110 334 457 1.3E-95 T 21-04-2016 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 PANTHER PTHR10357:SF110 478 568 1.3E-95 T 21-04-2016 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 PANTHER PTHR10357 3 307 1.3E-95 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 PANTHER PTHR10357 334 457 1.3E-95 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 PANTHER PTHR10357 478 568 1.3E-95 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 SMART SM00642 112 455 4.0E-8 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 Gene3D G3DSA:3.20.20.80 107 436 1.6E-77 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 Gene3D G3DSA:3.20.20.80 478 512 1.6E-77 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 SUPERFAMILY SSF51445 87 513 1.77E-93 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS18875 da22282d065c317e02936d747409f37e 602 TIGRFAM TIGR02402 trehalose_TreZ: malto-oligosyltrehalose trehalohydrolase 11 552 4.6E-202 T 21-04-2016 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902|UniPathway: UPA00299 SPH21_RS18875 da22282d065c317e02936d747409f37e 602 Gene3D G3DSA:2.60.40.10 2 90 1.1E-20 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS18875 da22282d065c317e02936d747409f37e 602 SUPERFAMILY SSF81296 2 91 2.4E-12 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS18875 da22282d065c317e02936d747409f37e 602 Pfam PF11941 Domain of unknown function (DUF3459) 498 590 4.8E-8 T 21-04-2016 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) SPH21_RS10805 58eb037f7b34f113fb5810e96236ff1a 2361 Pfam PF14349 Motility related/secretion protein 1091 1619 5.8E-160 T 21-04-2016 IPR025684 Gliding motility protein SprA N-terminal domain SPH21_RS10805 58eb037f7b34f113fb5810e96236ff1a 2361 Pfam PF14349 Motility related/secretion protein 76 358 2.3E-36 T 21-04-2016 IPR025684 Gliding motility protein SprA N-terminal domain SPH21_RS10805 58eb037f7b34f113fb5810e96236ff1a 2361 TIGRFAM TIGR04189 surface_SprA: cell surface protein SprA 67 2360 0.0 T 21-04-2016 IPR026377 Cell surface SprA SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 PANTHER PTHR26402 3 228 1.3E-53 T 21-04-2016 SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 Gene3D G3DSA:1.10.10.10 134 229 6.2E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 SMART SM00862 154 228 1.7E-17 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 PANTHER PTHR26402:SF292 3 228 1.3E-53 T 21-04-2016 SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 SMART SM00448 3 115 2.0E-30 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 Gene3D G3DSA:3.40.50.2300 3 124 1.6E-31 T 21-04-2016 SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 Pfam PF00072 Response regulator receiver domain 6 115 1.0E-23 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 Pfam PF00486 Transcriptional regulatory protein, C terminal 155 228 3.1E-17 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 SUPERFAMILY SSF52172 4 130 8.4E-32 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10120 e4ca52f53cfce2d70a7f78fe895c0719 231 SUPERFAMILY SSF46894 133 229 3.12E-19 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS15640 9d6b966f508d37260be51970eb77f2e3 190 Gene3D G3DSA:3.90.950.10 7 189 6.2E-64 T 21-04-2016 IPR029001 Inosine triphosphate pyrophosphatase-like SPH21_RS15640 9d6b966f508d37260be51970eb77f2e3 190 SUPERFAMILY SSF52972 5 189 1.05E-58 T 21-04-2016 IPR029001 Inosine triphosphate pyrophosphatase-like SPH21_RS15640 9d6b966f508d37260be51970eb77f2e3 190 Pfam PF02545 Maf-like protein 9 189 5.3E-56 T 21-04-2016 IPR003697 Maf-like protein GO:0005737 SPH21_RS15640 9d6b966f508d37260be51970eb77f2e3 190 PIRSF PIRSF006305 1 190 8.8E-57 T 21-04-2016 IPR003697 Maf-like protein GO:0005737 SPH21_RS15640 9d6b966f508d37260be51970eb77f2e3 190 Hamap MF_00528 Septum formation protein Maf [maf]. 8 190 25.463 T 21-04-2016 IPR003697 Maf-like protein GO:0005737 SPH21_RS15640 9d6b966f508d37260be51970eb77f2e3 190 PANTHER PTHR11746 125 179 1.7E-12 T 21-04-2016 SPH21_RS15640 9d6b966f508d37260be51970eb77f2e3 190 TIGRFAM TIGR00172 maf: septum formation protein Maf 7 187 1.7E-46 T 21-04-2016 IPR003697 Maf-like protein GO:0005737 SPH21_RS06045 9ef583d7c1f43fbba1d5d087fece22d4 221 Pfam PF00005 ABC transporter 21 169 8.0E-34 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS06045 9ef583d7c1f43fbba1d5d087fece22d4 221 Gene3D G3DSA:3.40.50.300 1 220 4.5E-63 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06045 9ef583d7c1f43fbba1d5d087fece22d4 221 SMART SM00382 30 218 4.3E-8 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS06045 9ef583d7c1f43fbba1d5d087fece22d4 221 SUPERFAMILY SSF52540 1 220 1.33E-67 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06045 9ef583d7c1f43fbba1d5d087fece22d4 221 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS06045 9ef583d7c1f43fbba1d5d087fece22d4 221 PANTHER PTHR24220 3 221 9.1E-97 T 21-04-2016 SPH21_RS06045 9ef583d7c1f43fbba1d5d087fece22d4 221 PANTHER PTHR24220:SF342 3 221 9.1E-97 T 21-04-2016 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 SUPERFAMILY SSF52540 3 190 1.19E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 Gene3D G3DSA:3.40.50.300 3 188 1.1E-65 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 PANTHER PTHR23359 2 190 1.1E-80 T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 PRINTS PR00094 Adenylate kinase signature 135 150 1.2E-30 T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 PRINTS PR00094 Adenylate kinase signature 82 98 1.2E-30 T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 PRINTS PR00094 Adenylate kinase signature 152 166 1.2E-30 T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 PRINTS PR00094 Adenylate kinase signature 33 47 1.2E-30 T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 PRINTS PR00094 Adenylate kinase signature 5 18 1.2E-30 T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 ProSitePatterns PS00113 Adenylate kinase signature. 82 93 - T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 Pfam PF00406 Adenylate kinase 6 165 5.7E-54 T 21-04-2016 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 Hamap MF_00235 Adenylate kinase [adk]. 2 188 44.606 T 21-04-2016 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS00370 098f069aedc0feb3fc04ffbfeaf604b8 190 TIGRFAM TIGR01351 adk: adenylate kinase 3 129 4.9E-50 T 21-04-2016 IPR006259 Adenylate kinase subfamily GO:0004017|GO:0005524|GO:0016776 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|UniPathway: UPA00588 SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 SUPERFAMILY SSF53335 264 318 2.03E-8 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 SUPERFAMILY SSF53335 79 194 2.03E-8 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 PIRSF PIRSF018005 2 322 1.0E-84 T 21-04-2016 IPR017804 Methyltransferase EgtD-like SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 PANTHER PTHR30468 18 315 2.3E-56 T 21-04-2016 SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 Pfam PF10017 Histidine-specific methyltransferase, SAM-dependent 195 316 2.7E-33 T 21-04-2016 IPR019257 Histidine-specific methyltransferase, SAM-dependent SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 Gene3D G3DSA:3.40.50.150 82 199 1.9E-4 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 Gene3D G3DSA:3.40.50.150 286 307 1.9E-4 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS12720 ce8fed13a6daa78cfa2592cd37630002 323 PANTHER PTHR30468:SF6 18 315 2.3E-56 T 21-04-2016 SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 Gene3D G3DSA:3.40.980.10 160 315 1.3E-44 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 SUPERFAMILY SSF53218 172 314 2.36E-31 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 SUPERFAMILY SSF63882 1 173 1.96E-41 T 21-04-2016 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 PANTHER PTHR10192 1 313 3.3E-90 T 21-04-2016 SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 Pfam PF03453 MoeA N-terminal region (domain I and II) 2 164 1.1E-27 T 21-04-2016 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 Gene3D G3DSA:3.90.105.10 129 159 2.0E-12 T 21-04-2016 SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 Pfam PF00994 Probable molybdopterin binding domain 178 314 2.2E-21 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 SMART SM00852 177 315 9.8E-28 T 21-04-2016 IPR001453 MoaB/Mog domain SPH21_RS18680 faca98331385b6e2a3b8ed9978914597 390 Gene3D G3DSA:2.170.190.11 44 128 1.6E-19 T 21-04-2016 SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 PANTHER PTHR11624:SF2 3 317 3.7E-111 T 21-04-2016 SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 Pfam PF02780 Transketolase, C-terminal domain 186 306 3.6E-32 T 21-04-2016 IPR033248 Transketolase, C-terminal domain SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 SUPERFAMILY SSF52518 3 176 1.34E-55 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 SUPERFAMILY SSF52922 183 315 5.76E-35 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 Pfam PF02779 Transketolase, pyrimidine binding domain 9 171 5.4E-34 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 Gene3D G3DSA:3.40.50.920 187 314 2.0E-39 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 SMART SM00861 10 175 6.8E-48 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 Gene3D G3DSA:3.40.50.970 4 186 1.1E-59 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS19445 a7496772c94db13b868a22ca948e5ecd 317 PANTHER PTHR11624 3 317 3.7E-111 T 21-04-2016 IPR033247 Transketolase family SPH21_RS00930 348ae0c10ebad8b4afc9ec75bb6e6334 472 Pfam PF05090 Vitamin K-dependent gamma-carboxylase 24 448 2.8E-131 T 21-04-2016 IPR007782 Vitamin K-dependent gamma-carboxylase GO:0008488|GO:0017187 KEGG: 00130+4.1.1.90 SPH21_RS00930 348ae0c10ebad8b4afc9ec75bb6e6334 472 PANTHER PTHR12639:SF7 9 448 9.2E-70 T 21-04-2016 SPH21_RS00930 348ae0c10ebad8b4afc9ec75bb6e6334 472 SMART SM00752 13 279 7.3E-36 T 21-04-2016 IPR011020 HTTM SPH21_RS00930 348ae0c10ebad8b4afc9ec75bb6e6334 472 PANTHER PTHR12639 9 448 9.2E-70 T 21-04-2016 IPR007782 Vitamin K-dependent gamma-carboxylase GO:0008488|GO:0017187 KEGG: 00130+4.1.1.90 SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 SMART SM00850 139 230 3.9E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 Gene3D G3DSA:2.40.50.40 131 198 9.8E-20 T 21-04-2016 SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 Pfam PF00072 Response regulator receiver domain 4 109 1.2E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 SUPERFAMILY SSF52172 2 121 5.83E-26 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 Gene3D G3DSA:3.40.50.2300 1 116 1.3E-26 T 21-04-2016 SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 Pfam PF04397 LytTr DNA-binding domain 140 228 3.3E-17 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 SMART SM00448 1 109 2.0E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23745 ddf587499c61aeed4ca52d143b74b5be 238 PANTHER PTHR26402 1 109 3.3E-28 T 21-04-2016 SPH21_RS11695 522a526a60a890a70cd7408f4f16eb9d 157 Pfam PF04170 NlpE N-terminal domain 63 147 2.6E-27 T 21-04-2016 IPR007298 Copper resistance lipoprotein NlpE SPH21_RS21425 e1c84bb137913c2e9cea94269fa03886 172 SUPERFAMILY SSF54909 1 87 4.29E-10 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS21425 e1c84bb137913c2e9cea94269fa03886 172 PANTHER PTHR40057 2 172 2.8E-20 T 21-04-2016 SPH21_RS21425 e1c84bb137913c2e9cea94269fa03886 172 Gene3D G3DSA:3.30.70.900 1 83 1.1E-6 T 21-04-2016 SPH21_RS21425 e1c84bb137913c2e9cea94269fa03886 172 PANTHER PTHR40057:SF1 2 172 2.8E-20 T 21-04-2016 SPH21_RS21425 e1c84bb137913c2e9cea94269fa03886 172 Pfam PF03992 Antibiotic biosynthesis monooxygenase 2 78 2.2E-5 T 21-04-2016 IPR007138 Antibiotic biosynthesis monooxygenase domain SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 224 6.9E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Pfam PF13715 CarboxypepD_reg-like domain 26 107 3.2E-18 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.170.130.10 111 225 4.2E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 200 230 3.7E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 1089 1.2E-256 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 PANTHER PTHR11532 1 304 3.9E-256 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 PANTHER PTHR11532 331 466 3.9E-256 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 PANTHER PTHR11532 540 1087 3.9E-256 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 SUPERFAMILY SSF49464 25 105 2.22E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 PANTHER PTHR11532:SF57 1 304 3.9E-256 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 PANTHER PTHR11532:SF57 331 466 3.9E-256 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 PANTHER PTHR11532:SF57 540 1087 3.9E-256 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 SUPERFAMILY SSF56935 996 1088 1.14E-81 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 SUPERFAMILY SSF56935 913 956 1.14E-81 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 SUPERFAMILY SSF56935 340 815 1.14E-81 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 SUPERFAMILY SSF56935 103 249 1.14E-81 T 21-04-2016 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.60.40.1120 26 110 2.0E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.40.170.20 458 500 2.2E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.40.170.20 989 1088 2.2E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.40.170.20 922 954 2.2E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.40.170.20 532 832 2.2E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.40.170.20 345 416 2.2E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16250 e63cd6ebc978f4c94797ace6b4a6a1b6 1089 Gene3D G3DSA:2.40.170.20 226 248 2.2E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 PANTHER PTHR11938:SF47 45 345 2.0E-90 T 21-04-2016 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 Pfam PF01180 Dihydroorotate dehydrogenase 49 341 5.4E-98 T 21-04-2016 IPR005720 Dihydroorotate dehydrogenase domain GO:0005737|GO:0016627|GO:0055114 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 PANTHER PTHR11938 45 345 2.0E-90 T 21-04-2016 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 TIGRFAM TIGR01036 pyrD_sub2: dihydroorotate dehydrogenase (fumarate) 2 342 1.7E-130 T 21-04-2016 IPR005719 Dihydroorotate dehydrogenase, class 2 GO:0004152|GO:0006207|GO:0016020|GO:0055114 KEGG: 00240+1.3.5.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 Gene3D G3DSA:3.20.20.70 1 340 1.3E-127 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 Hamap MF_00225 Dihydroorotate dehydrogenase (quinone) [pyrD]. 1 339 47.768 T 21-04-2016 IPR005719 Dihydroorotate dehydrogenase, class 2 GO:0004152|GO:0006207|GO:0016020|GO:0055114 KEGG: 00240+1.3.5.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 PIRSF PIRSF000164 9 344 7.1E-107 T 21-04-2016 IPR012135 Dihydroorotate dehydrogenase, class 1/ 2 GO:0004152|GO:0006222|GO:0055114 Reactome: REACT_1698 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 ProSitePatterns PS00912 Dihydroorotate dehydrogenase signature 2. 295 315 - T 21-04-2016 IPR001295 Dihydroorotate dehydrogenase, conserved site GO:0004152|GO:0006207|GO:0055114 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 ProSitePatterns PS00911 Dihydroorotate dehydrogenase signature 1. 84 103 - T 21-04-2016 IPR001295 Dihydroorotate dehydrogenase, conserved site GO:0004152|GO:0006207|GO:0055114 SPH21_RS17595 7ec6d648cfe52290820f5101b9068526 345 SUPERFAMILY SSF51395 1 340 9.77E-102 T 21-04-2016 SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 Gene3D G3DSA:3.40.50.300 1 286 1.0E-132 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 SUPERFAMILY SSF52317 291 529 6.88E-80 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 Gene3D G3DSA:3.40.50.880 290 530 1.9E-100 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 Pfam PF06418 CTP synthase N-terminus 3 267 1.8E-124 T 21-04-2016 IPR017456 CTP synthase, N-terminal GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: REACT_1698|UniPathway: UPA00159 SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 Hamap MF_01227 CTP synthase [pyrG]. 2 533 50.622 T 21-04-2016 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: REACT_1698|UniPathway: UPA00159 SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 SUPERFAMILY SSF52540 1 269 3.32E-121 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 Pfam PF00117 Glutamine amidotransferase class-I 303 527 2.3E-58 T 21-04-2016 IPR017926 Glutamine amidotransferase Reactome: REACT_1698 SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 PANTHER PTHR11550 1 530 0.0 T 21-04-2016 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: REACT_1698|UniPathway: UPA00159 SPH21_RS17510 a7c78dc7e51f16fc6f5da1632d594857 536 TIGRFAM TIGR00337 PyrG: CTP synthase 1 528 4.2E-245 T 21-04-2016 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: REACT_1698|UniPathway: UPA00159 SPH21_RS24005 120e72c37a61ab0a95f0c6f59773adc0 211 Gene3D G3DSA:3.40.50.360 1 208 2.3E-58 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS24005 120e72c37a61ab0a95f0c6f59773adc0 211 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 2 207 26.5 T 21-04-2016 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 SPH21_RS24005 120e72c37a61ab0a95f0c6f59773adc0 211 PANTHER PTHR10204:SF16 1 209 4.4E-48 T 21-04-2016 SPH21_RS24005 120e72c37a61ab0a95f0c6f59773adc0 211 Pfam PF02525 Flavodoxin-like fold 3 203 2.0E-43 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS24005 120e72c37a61ab0a95f0c6f59773adc0 211 PANTHER PTHR10204 1 209 4.4E-48 T 21-04-2016 SPH21_RS24005 120e72c37a61ab0a95f0c6f59773adc0 211 SUPERFAMILY SSF52218 1 207 1.52E-48 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS05500 3bd535e35f3c5d338463842810a15b70 179 Gene3D G3DSA:3.40.50.300 9 171 2.3E-47 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05500 3bd535e35f3c5d338463842810a15b70 179 Pfam PF13521 AAA domain 9 166 1.6E-24 T 21-04-2016 SPH21_RS05500 3bd535e35f3c5d338463842810a15b70 179 PANTHER PTHR37512 9 178 3.6E-36 T 21-04-2016 SPH21_RS05500 3bd535e35f3c5d338463842810a15b70 179 SUPERFAMILY SSF52540 9 164 7.07E-17 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09005 45a0ef5d8948db7d60ee721c81044495 446 SUPERFAMILY SSF53756 194 442 2.76E-5 T 21-04-2016 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 Gene3D G3DSA:3.90.190.20 305 437 4.1E-30 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 SUPERFAMILY SSF53623 90 304 4.71E-46 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 PANTHER PTHR23135 1 437 2.5E-125 T 21-04-2016 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 SUPERFAMILY SSF63418 11 86 1.15E-17 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 PANTHER PTHR23135:SF3 1 437 2.5E-125 T 21-04-2016 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 Pfam PF08245 Mur ligase middle domain 95 285 2.0E-43 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 Gene3D G3DSA:3.40.1390.10 12 61 8.9E-16 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 Gene3D G3DSA:3.40.1190.10 73 303 2.8E-61 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 SUPERFAMILY SSF53244 307 436 1.05E-25 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 TIGRFAM TIGR01143 murF: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 18 437 7.0E-113 T 21-04-2016 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 Hamap MF_02019 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [murF]. 4 437 29.113 T 21-04-2016 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 Pfam PF02875 Mur ligase family, glutamate ligase domain 308 370 4.7E-9 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS06655 dc81a90dafc64de0e4731e5f9a6be907 437 Pfam PF01225 Mur ligase family, catalytic domain 15 92 2.3E-8 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 SMART SM00342 221 305 1.8E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 PANTHER PTHR11019 25 313 2.6E-30 T 21-04-2016 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 Pfam PF12833 Helix-turn-helix domain 229 306 1.1E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 Gene3D G3DSA:1.10.10.60 260 308 3.0E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 PANTHER PTHR11019:SF45 25 313 2.6E-30 T 21-04-2016 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 Gene3D G3DSA:2.60.120.280 48 183 4.2E-12 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 SUPERFAMILY SSF46689 261 308 1.57E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 Gene3D G3DSA:1.10.10.60 226 258 2.2E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 Pfam PF02311 AraC-like ligand binding domain 43 162 2.3E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS04515 fe639aa8770014fa28cb91b3e978d9e6 314 SUPERFAMILY SSF51215 47 183 3.27E-12 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS06390 128dd9ac5f30109851a640bde1333bba 171 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 91 123 5.0E-6 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS06390 128dd9ac5f30109851a640bde1333bba 171 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 13 46 1.8E-6 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS06390 128dd9ac5f30109851a640bde1333bba 171 Gene3D G3DSA:2.160.10.10 4 162 6.0E-46 T 21-04-2016 SPH21_RS06390 128dd9ac5f30109851a640bde1333bba 171 SUPERFAMILY SSF51161 5 166 4.99E-45 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS06390 128dd9ac5f30109851a640bde1333bba 171 PANTHER PTHR13061 1 165 9.9E-68 T 21-04-2016 SPH21_RS19230 ce4a9d5a5c5e58ba2973f96f11cc4779 255 Pfam PF12706 Beta-lactamase superfamily domain 46 224 1.8E-34 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS19230 ce4a9d5a5c5e58ba2973f96f11cc4779 255 SMART SM00849 34 218 2.4E-4 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS19230 ce4a9d5a5c5e58ba2973f96f11cc4779 255 PANTHER PTHR12553:SF7 5 254 3.1E-59 T 21-04-2016 SPH21_RS19230 ce4a9d5a5c5e58ba2973f96f11cc4779 255 Gene3D G3DSA:3.60.15.10 2 253 2.5E-70 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS19230 ce4a9d5a5c5e58ba2973f96f11cc4779 255 SUPERFAMILY SSF56281 3 254 7.26E-43 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS19230 ce4a9d5a5c5e58ba2973f96f11cc4779 255 PANTHER PTHR12553 5 254 3.1E-59 T 21-04-2016 SPH21_RS23060 4168ed6175d5cd8c416de62d729d885b 210 PANTHER PTHR31876:SF1 12 195 2.1E-22 T 21-04-2016 SPH21_RS23060 4168ed6175d5cd8c416de62d729d885b 210 Pfam PF04367 Protein of unknown function (DUF502) 64 164 1.6E-23 T 21-04-2016 IPR007462 Protein of unknown function DUF502 SPH21_RS23060 4168ed6175d5cd8c416de62d729d885b 210 PANTHER PTHR31876 12 195 2.1E-22 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 SUPERFAMILY SSF49464 27 126 1.14E-10 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 Gene3D G3DSA:2.40.170.20 233 307 1.3E-31 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 Gene3D G3DSA:2.40.170.20 1015 1061 1.3E-31 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 Gene3D G3DSA:2.40.170.20 575 942 1.3E-31 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 Gene3D G3DSA:2.40.170.20 346 539 1.3E-31 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 Gene3D G3DSA:2.170.130.10 117 232 7.5E-6 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 Pfam PF13620 Carboxypeptidase regulatory-like domain 26 106 1.5E-15 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 SUPERFAMILY SSF56935 113 310 1.51E-37 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 SUPERFAMILY SSF56935 823 944 1.51E-37 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 SUPERFAMILY SSF56935 734 784 1.51E-37 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 SUPERFAMILY SSF56935 357 610 1.51E-37 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 SUPERFAMILY SSF56935 1007 1070 1.51E-37 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 SUPERFAMILY SSF56935 643 693 1.51E-37 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 PANTHER PTHR30069 1 1062 1.9E-201 T 21-04-2016 SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 Gene3D G3DSA:2.60.40.1120 27 116 1.6E-6 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS17120 d9f86d907b3f45cbacb2a2b17e3156af 1124 PANTHER PTHR30069:SF6 1 1062 1.9E-201 T 21-04-2016 SPH21_RS07410 44ecbc2943b4b58b30e3cc0f304ce8d5 96 Pfam PF02617 ATP-dependent Clp protease adaptor protein ClpS 24 88 2.1E-19 T 21-04-2016 IPR003769 Adaptor protein ClpS, core GO:0030163 SPH21_RS07410 44ecbc2943b4b58b30e3cc0f304ce8d5 96 Gene3D G3DSA:3.30.1390.10 4 96 2.2E-22 T 21-04-2016 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SPH21_RS07410 44ecbc2943b4b58b30e3cc0f304ce8d5 96 PANTHER PTHR33473 26 96 3.7E-13 T 21-04-2016 SPH21_RS07410 44ecbc2943b4b58b30e3cc0f304ce8d5 96 SUPERFAMILY SSF54736 24 95 3.87E-20 T 21-04-2016 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 Pfam PF12002 MgsA AAA+ ATPase C terminal 254 420 9.6E-71 T 21-04-2016 IPR021886 MgsA AAA+ ATPase C-terminal SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 PANTHER PTHR13779:SF7 6 423 7.1E-196 T 21-04-2016 SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 PANTHER PTHR13779 6 423 7.1E-196 T 21-04-2016 SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 Gene3D G3DSA:3.40.50.300 4 145 1.0E-31 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 Gene3D G3DSA:1.20.272.10 235 333 6.1E-45 T 21-04-2016 SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 Gene3D G3DSA:1.10.8.60 146 223 2.0E-8 T 21-04-2016 SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 Gene3D G3DSA:1.10.3710.10 334 423 5.4E-31 T 21-04-2016 SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 SMART SM00382 40 157 2.6E-15 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 44 152 1.2E-16 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 SUPERFAMILY SSF48019 239 423 2.55E-75 T 21-04-2016 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: REACT_152|Reactome: REACT_1538|Reactome: REACT_216|Reactome: REACT_22172|Reactome: REACT_383 SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 SUPERFAMILY SSF52540 5 221 3.19E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06690 0dd8d20afe8935c14911452090741369 426 Pfam PF16193 AAA C-terminal domain 184 253 2.4E-22 T 21-04-2016 IPR032423 AAA ATPase, C-terminal domain SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 SUPERFAMILY SSF53649 22 447 1.01E-121 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 PANTHER PTHR10342:SF199 291 452 7.1E-137 T 21-04-2016 SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 PANTHER PTHR10342:SF199 4 272 7.1E-137 T 21-04-2016 SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 Gene3D G3DSA:3.40.720.10 21 360 1.2E-107 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 ProSitePatterns PS00523 Sulfatases signature 1. 70 82 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 ProSitePatterns PS00149 Sulfatases signature 2. 117 127 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 Pfam PF00884 Sulfatase 24 345 5.5E-70 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 PANTHER PTHR10342 291 452 7.1E-137 T 21-04-2016 SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 PANTHER PTHR10342 4 272 7.1E-137 T 21-04-2016 SPH21_RS22515 9b7dcc91811a3955a91d0073baee174c 452 Gene3D G3DSA:3.30.1120.10 361 450 5.3E-14 T 21-04-2016 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 Pfam PF13437 HlyD family secretion protein 242 342 2.2E-14 T 21-04-2016 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 Gene3D G3DSA:2.40.50.100 68 99 7.6E-16 T 21-04-2016 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 Gene3D G3DSA:2.40.50.100 240 274 7.6E-16 T 21-04-2016 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 77 97 8.8E-12 T 21-04-2016 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 355 370 8.8E-12 T 21-04-2016 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature 287 311 8.8E-12 T 21-04-2016 IPR003997 RTX secretion protein D, Gram-negative bacteria GO:0009306|GO:0016020 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 SUPERFAMILY SSF51230 14 110 8.63E-5 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 Pfam PF13533 Biotin-lipoyl like 68 98 6.8E-10 T 21-04-2016 SPH21_RS09370 a7dfa5588920a32fcd45677c68a241b2 394 PANTHER PTHR30386 28 393 5.0E-33 T 21-04-2016 SPH21_RS17605 fdaf115b7e332a63a776828ff35de004 442 Pfam PF17116 Domain of unknown function (DUF5103) 50 336 2.5E-95 T 21-04-2016 IPR031345 Protein of unknown function DUF5103 SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 Gene3D G3DSA:3.30.360.10 132 346 4.7E-33 T 21-04-2016 SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 135 236 1.8E-10 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 SUPERFAMILY SSF55347 128 284 4.58E-27 T 21-04-2016 SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 PANTHER PTHR22604:SF53 3 351 8.4E-111 T 21-04-2016 SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 3 122 1.5E-26 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 PANTHER PTHR22604 3 351 8.4E-111 T 21-04-2016 SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 Gene3D G3DSA:3.40.50.720 2 131 1.8E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS16860 6d0c7c065e681b84175c7970971d33e6 351 SUPERFAMILY SSF51735 3 157 3.08E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 SMART SM00387 347 458 2.1E-23 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 Gene3D G3DSA:3.30.565.10 290 460 6.9E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 PANTHER PTHR24423 229 456 8.2E-47 T 21-04-2016 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 403 413 1.4E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 418 436 1.4E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 442 455 1.4E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 385 399 1.4E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 Gene3D G3DSA:1.10.287.130 230 289 3.3E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 SMART SM00388 236 304 3.6E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 SUPERFAMILY SSF55874 301 458 9.95E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 Pfam PF00512 His Kinase A (phospho-acceptor) domain 236 301 1.4E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 SUPERFAMILY SSF47384 224 303 2.16E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10125 4bb11516f2a7c76dd17c6c68643baf13 463 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 353 456 5.1E-19 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 ProSitePatterns PS00151 Acylphosphatase signature 2. 32 48 - T 21-04-2016 IPR017968 Acylphosphatase, conserved site KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 ProSitePatterns PS00150 Acylphosphatase signature 1. 8 18 - T 21-04-2016 IPR017968 Acylphosphatase, conserved site KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 Gene3D G3DSA:3.30.70.100 1 87 4.5E-29 T 21-04-2016 SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 PANTHER PTHR10029 4 89 3.5E-25 T 21-04-2016 SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 SUPERFAMILY SSF54975 1 88 5.45E-27 T 21-04-2016 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 PRINTS PR00112 Acylphosphatase signature 3 18 3.2E-5 T 21-04-2016 IPR020456 Acylphosphatase GO:0003998 KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 PRINTS PR00112 Acylphosphatase signature 24 49 3.2E-5 T 21-04-2016 IPR020456 Acylphosphatase GO:0003998 KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SPH21_RS05600 99778d090e22cf75f329cec9e798bb61 90 Pfam PF00708 Acylphosphatase 1 87 3.9E-24 T 21-04-2016 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 Pfam PF02311 AraC-like ligand binding domain 37 141 3.1E-12 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 Gene3D G3DSA:2.60.120.280 36 162 1.4E-11 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 Gene3D G3DSA:1.10.10.60 239 284 3.6E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 SUPERFAMILY SSF51215 36 146 7.59E-13 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 SUPERFAMILY SSF46689 239 284 3.76E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 Pfam PF12833 Helix-turn-helix domain 205 284 4.9E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 251 266 3.2E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 266 282 3.2E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 SMART SM00342 198 282 4.0E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 PANTHER PTHR11019:SF45 38 285 5.1E-39 T 21-04-2016 SPH21_RS22315 277da6526e6830e8d61dda6183ccb7cc 285 PANTHER PTHR11019 38 285 5.1E-39 T 21-04-2016 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 Gene3D G3DSA:3.30.450.20 5 118 1.5E-24 T 21-04-2016 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 342 352 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 381 394 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 357 375 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 PRINTS PR00344 Bacterial sensor protein C-terminal signature 324 338 2.0E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 Pfam PF00512 His Kinase A (phospho-acceptor) domain 174 242 1.4E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 Gene3D G3DSA:1.10.287.130 166 227 1.3E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 Gene3D G3DSA:3.30.565.10 228 393 1.9E-40 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 SMART SM00091 5 72 1.8E-9 T 21-04-2016 IPR000014 PAS domain SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 SMART SM00388 174 242 3.1E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 Pfam PF00989 PAS fold 7 118 7.2E-15 T 21-04-2016 IPR013767 PAS fold GO:0006355 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 SUPERFAMILY SSF55785 16 131 5.23E-28 T 21-04-2016 IPR000014 PAS domain SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 PANTHER PTHR24423 5 137 1.2E-85 T 21-04-2016 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 PANTHER PTHR24423 170 393 1.2E-85 T 21-04-2016 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 SUPERFAMILY SSF47384 165 243 1.18E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 SUPERFAMILY SSF55874 231 394 4.06E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 4 129 6.2E-29 T 21-04-2016 IPR000014 PAS domain SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 SMART SM00387 287 395 9.5E-27 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS17520 54aea2f2898b2024213e82ff735bbf9d 395 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 288 393 9.0E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16060 1e3b6bc41588c7958b5c7be8a14e0383 390 Gene3D G3DSA:1.20.1530.10 9 388 3.1E-145 T 21-04-2016 IPR023171 Na/H antiporter domain SPH21_RS16060 1e3b6bc41588c7958b5c7be8a14e0383 390 Hamap MF_01844 Na(+)/H(+) antiporter NhaA [nhaA]. 10 389 22.22 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS16060 1e3b6bc41588c7958b5c7be8a14e0383 390 Pfam PF06965 Na+/H+ antiporter 1 12 383 1.2E-145 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS16060 1e3b6bc41588c7958b5c7be8a14e0383 390 PANTHER PTHR30341:SF0 7 389 4.5E-150 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS16060 1e3b6bc41588c7958b5c7be8a14e0383 390 PANTHER PTHR30341 7 389 4.5E-150 T 21-04-2016 SPH21_RS16060 1e3b6bc41588c7958b5c7be8a14e0383 390 TIGRFAM TIGR00773 NhaA: Na+/H+ antiporter NhaA 13 383 4.8E-125 T 21-04-2016 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SPH21_RS20175 639469303a4c622199e302a4d511a139 138 PANTHER PTHR33797:SF1 1 138 2.8E-46 T 21-04-2016 SPH21_RS20175 639469303a4c622199e302a4d511a139 138 TIGRFAM TIGR03562 osmo_induc_OsmC: peroxiredoxin, OsmC subfamily 4 135 3.1E-51 T 21-04-2016 IPR019904 Peroxiredoxin OsmC GO:0004601|GO:0006979 KEGG: 00480+1.11.1.15 SPH21_RS20175 639469303a4c622199e302a4d511a139 138 SUPERFAMILY SSF82784 1 137 2.62E-33 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS20175 639469303a4c622199e302a4d511a139 138 Pfam PF02566 OsmC-like protein 43 134 2.3E-18 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS20175 639469303a4c622199e302a4d511a139 138 PANTHER PTHR33797 1 138 2.8E-46 T 21-04-2016 SPH21_RS20175 639469303a4c622199e302a4d511a139 138 Gene3D G3DSA:3.30.300.20 4 137 8.2E-45 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Gene3D G3DSA:3.40.50.10050 812 891 7.6E-26 T 21-04-2016 IPR023115 Translation initiation factor IF- 2, domain 3 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 PANTHER PTHR23115:SF184 865 1008 2.2E-195 T 21-04-2016 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 PANTHER PTHR23115:SF184 493 840 2.2E-195 T 21-04-2016 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 SUPERFAMILY SSF50447 913 1011 4.16E-34 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Pfam PF11987 Translation-initiation factor 2 805 902 7.8E-37 T 21-04-2016 IPR023115 Translation initiation factor IF- 2, domain 3 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Pfam PF04760 Translation initiation factor IF-2, N-terminal region 436 486 8.5E-12 T 21-04-2016 IPR006847 Translation initiation factor IF-2, N-terminal SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Gene3D G3DSA:2.40.30.10 683 777 6.0E-21 T 21-04-2016 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 PANTHER PTHR23115 865 1008 2.2E-195 T 21-04-2016 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 PANTHER PTHR23115 493 840 2.2E-195 T 21-04-2016 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 516 665 1.4E-29 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Hamap MF_00100_B Translation initiation factor IF-2 [infB]. 6 1010 17.002 T 21-04-2016 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Pfam PF00009 Elongation factor Tu GTP binding domain 514 672 4.3E-28 T 21-04-2016 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 SUPERFAMILY SSF50447 685 767 3.09E-22 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 SUPERFAMILY SSF52156 791 918 1.57E-37 T 21-04-2016 IPR023115 Translation initiation factor IF- 2, domain 3 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 TIGRFAM TIGR00487 IF-2: translation initiation factor IF-2 430 1011 6.3E-242 T 21-04-2016 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 SUPERFAMILY SSF52540 506 684 1.18E-47 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Gene3D G3DSA:2.40.30.10 914 1011 1.4E-39 T 21-04-2016 SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 Gene3D G3DSA:3.40.50.300 501 671 9.2E-42 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07960 4a2ae7f8b97f7381074e0807e4510889 1012 ProSitePatterns PS01176 Initiation factor 2 signature. 963 985 - T 21-04-2016 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 SUPERFAMILY SSF46689 357 447 5.02E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 SUPERFAMILY SSF52172 1 187 1.18E-29 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 Pfam PF02954 Bacterial regulatory protein, Fis family 405 445 1.3E-14 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 Gene3D G3DSA:1.10.8.60 316 388 3.2E-23 T 21-04-2016 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 SMART SM00382 163 306 1.5E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 Gene3D G3DSA:3.40.50.2300 2 133 6.8E-30 T 21-04-2016 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 Gene3D G3DSA:3.40.50.300 140 315 1.4E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 229 244 - T 21-04-2016 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 411 428 3.6E-8 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 428 447 3.6E-8 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 Pfam PF00072 Response regulator receiver domain 6 120 3.5E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 Pfam PF00158 Sigma-54 interaction domain 143 309 9.2E-61 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 Gene3D G3DSA:1.10.10.60 389 447 1.4E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 SMART SM00448 4 120 1.3E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 PANTHER PTHR32071 1 447 7.9E-167 T 21-04-2016 SPH21_RS05760 137dcadb030db4560342dadd15fc3750 447 SUPERFAMILY SSF52540 142 384 4.18E-65 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 135 199 2.1E-8 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 111 193 5.0E-10 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 SUPERFAMILY SSF56784 1 232 3.99E-38 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 PANTHER PTHR12725 1 239 1.2E-30 T 21-04-2016 SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 112 125 2.0E-8 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 160 180 2.0E-8 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 142 158 2.0E-8 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 2 13 2.0E-8 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 Gene3D G3DSA:3.40.50.1000 1 228 2.4E-35 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS13345 c6e40ccfbd249f50128f35e6b67309fc 239 Pfam PF13419 Haloacid dehalogenase-like hydrolase 61 199 2.1E-18 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS00040 713626489536c5303904101203fb2584 351 Hamap MF_00536 4-hydroxythreonine-4-phosphate dehydrogenase [pdxA]. 3 327 29.781 T 21-04-2016 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295|UniPathway: UPA00244 SPH21_RS00040 713626489536c5303904101203fb2584 351 PANTHER PTHR30004 1 339 3.3E-135 T 21-04-2016 SPH21_RS00040 713626489536c5303904101203fb2584 351 Gene3D G3DSA:3.40.718.10 2 331 1.4E-118 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS00040 713626489536c5303904101203fb2584 351 Pfam PF04166 Pyridoxal phosphate biosynthetic protein PdxA 35 323 1.2E-104 T 21-04-2016 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295|UniPathway: UPA00244 SPH21_RS00040 713626489536c5303904101203fb2584 351 SUPERFAMILY SSF53659 4 330 1.47E-93 T 21-04-2016 SPH21_RS00040 713626489536c5303904101203fb2584 351 PANTHER PTHR30004:SF6 1 339 3.3E-135 T 21-04-2016 SPH21_RS00040 713626489536c5303904101203fb2584 351 TIGRFAM TIGR00557 pdxA: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 7 326 2.9E-108 T 21-04-2016 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295|UniPathway: UPA00244 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 ProSitePatterns PS00153 ATP synthase gamma subunit signature. 278 291 - T 21-04-2016 IPR023632 ATPase, F1 complex, gamma subunit conserved site SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 Gene3D G3DSA:1.10.287.80 242 287 8.3E-30 T 21-04-2016 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 SUPERFAMILY SSF52943 2 292 9.81E-85 T 21-04-2016 IPR023633 ATPase, F1 complex, gamma subunit domain SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 Pfam PF00231 ATP synthase 3 292 1.9E-94 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 Hamap MF_00815 ATP synthase gamma chain [atpG]. 1 292 34.138 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 Gene3D G3DSA:3.40.1380.10 65 194 1.5E-41 T 21-04-2016 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 Gene3D G3DSA:1.10.287.80 207 241 2.2E-31 T 21-04-2016 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 Gene3D G3DSA:1.10.287.80 19 60 2.2E-31 T 21-04-2016 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 PRINTS PR00126 ATP synthase gamma subunit signature 239 258 7.7E-33 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 PRINTS PR00126 ATP synthase gamma subunit signature 270 291 7.7E-33 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 PRINTS PR00126 ATP synthase gamma subunit signature 73 92 7.7E-33 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 PRINTS PR00126 ATP synthase gamma subunit signature 169 186 7.7E-33 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 TIGRFAM TIGR01146 ATPsyn_F1gamma: ATP synthase F1, gamma subunit 1 292 6.5E-97 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS25750 28c28e243ffcb90eee142ecfe2fda63a 295 PANTHER PTHR11693 1 294 1.5E-112 T 21-04-2016 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS18560 8625d3d39da27c0f0f5bd0c6867122d6 177 SUPERFAMILY SSF53474 3 136 2.84E-17 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS18560 8625d3d39da27c0f0f5bd0c6867122d6 177 Gene3D G3DSA:3.40.50.1820 4 117 5.0E-13 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS18560 8625d3d39da27c0f0f5bd0c6867122d6 177 Pfam PF12697 Alpha/beta hydrolase family 4 150 2.2E-9 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 SUPERFAMILY SSF143800 1 80 1.92E-19 T 21-04-2016 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 Hamap MF_00502 50S ribosomal protein L31 type B [rpmE2]. 1 82 25.028 T 21-04-2016 IPR027493 Ribosomal protein L31 type B GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 ProSitePatterns PS01143 Ribosomal protein L31 signature. 50 71 - T 21-04-2016 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 PANTHER PTHR33280 1 80 4.3E-27 T 21-04-2016 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 PANTHER PTHR33280:SF2 1 80 4.3E-27 T 21-04-2016 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 PRINTS PR01249 Ribosomal protein L31 signature 2 19 4.6E-14 T 21-04-2016 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 PRINTS PR01249 Ribosomal protein L31 signature 46 61 4.6E-14 T 21-04-2016 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 PRINTS PR01249 Ribosomal protein L31 signature 61 79 4.6E-14 T 21-04-2016 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 TIGRFAM TIGR00105 L31: ribosomal protein bL31 1 81 1.2E-17 T 21-04-2016 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS15145 e499f545d308222f98e851e7a269e9cc 82 Pfam PF01197 Ribosomal protein L31 1 80 1.0E-26 T 21-04-2016 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS25905 803a2cd270c9c5271dcdbf6d5c5c3934 110 TIGRFAM TIGR04019 B_thiol_YtxJ: bacillithiol system protein YtxJ 5 104 2.8E-34 T 21-04-2016 IPR022551 Protein of unknown function DUF2847 SPH21_RS25905 803a2cd270c9c5271dcdbf6d5c5c3934 110 Pfam PF11009 Protein of unknown function (DUF2847) 5 104 4.9E-34 T 21-04-2016 IPR022551 Protein of unknown function DUF2847 SPH21_RS25905 803a2cd270c9c5271dcdbf6d5c5c3934 110 SUPERFAMILY SSF52833 2 92 2.9E-5 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 SUPERFAMILY SSF52540 393 601 8.64E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 Pfam PF17191 RecG wedge domain 11 166 3.2E-18 T 21-04-2016 IPR033454 RecG, wedge domain SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 Pfam PF00271 Helicase conserved C-terminal domain 481 592 7.8E-19 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 Gene3D G3DSA:3.40.50.300 266 456 2.1E-56 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 SUPERFAMILY SSF52540 189 454 1.44E-61 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 SMART SM00490 510 592 8.7E-22 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 SUPERFAMILY SSF50249 5 171 2.57E-38 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 SMART SM00487 270 461 1.7E-33 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 TIGRFAM TIGR00643 recG: ATP-dependent DNA helicase RecG 31 666 2.0E-218 T 21-04-2016 IPR004609 ATP-dependent DNA helicase RecG GO:0004003|GO:0006281|GO:0006310 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 Gene3D G3DSA:3.40.50.300 457 640 1.5E-40 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031:SF249 304 605 6.9E-123 T 21-04-2016 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031:SF249 274 287 6.9E-123 T 21-04-2016 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031:SF249 131 252 6.9E-123 T 21-04-2016 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031:SF249 629 688 6.9E-123 T 21-04-2016 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 Gene3D G3DSA:2.40.50.140 49 144 1.3E-20 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 Pfam PF00270 DEAD/DEAH box helicase 275 436 4.9E-20 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031 304 605 6.9E-123 T 21-04-2016 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031 274 287 6.9E-123 T 21-04-2016 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031 131 252 6.9E-123 T 21-04-2016 SPH21_RS05690 bfc68256cb02291a9c2e9adbea4a545a 703 PANTHER PTHR24031 629 688 6.9E-123 T 21-04-2016 SPH21_RS05615 2604b8dcab749c8605ffb6a15b81db0c 268 Pfam PF14125 Domain of unknown function (DUF4292) 59 262 3.2E-42 T 21-04-2016 IPR025634 Protein of unknown function DUF4292 SPH21_RS05615 2604b8dcab749c8605ffb6a15b81db0c 268 Gene3D G3DSA:2.50.20.10 20 238 5.5E-5 T 21-04-2016 SPH21_RS23740 4feb345447b6aff3d6153ae4f0c43f4d 358 Pfam PF06580 Histidine kinase 172 247 7.7E-25 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS23740 4feb345447b6aff3d6153ae4f0c43f4d 358 PANTHER PTHR34220 14 358 3.0E-62 T 21-04-2016 SPH21_RS23740 4feb345447b6aff3d6153ae4f0c43f4d 358 PANTHER PTHR34220:SF1 14 358 3.0E-62 T 21-04-2016 SPH21_RS02720 46db60d937fba1fd3eca5fe7c66e49ad 355 Pfam PF09925 Predicted membrane protein (DUF2157) 19 170 2.6E-7 T 21-04-2016 IPR018677 Domain of unknown function DUF2157 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 SUPERFAMILY SSF63380 1 86 1.36E-20 T 21-04-2016 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 SUPERFAMILY SSF63380 91 193 8.5E-31 T 21-04-2016 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 Gene3D G3DSA:2.40.30.20 5 102 4.1E-26 T 21-04-2016 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 Gene3D G3DSA:2.40.30.20 103 192 3.3E-28 T 21-04-2016 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 Pfam PF00677 Lumazine binding domain 3 84 2.4E-17 T 21-04-2016 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 Pfam PF00677 Lumazine binding domain 98 182 4.0E-22 T 21-04-2016 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 TIGRFAM TIGR00187 ribE: riboflavin synthase, alpha subunit 1 196 7.0E-59 T 21-04-2016 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 PIRSF PIRSF000498 1 200 2.5E-63 T 21-04-2016 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS19350 b9a1bdfba726598c4efd348f492bb7f2 201 PANTHER PTHR21098 1 196 6.3E-81 T 21-04-2016 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 Gene3D G3DSA:3.30.200.20 14 116 1.1E-23 T 21-04-2016 SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 PANTHER PTHR24362:SF160 15 250 1.9E-46 T 21-04-2016 SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 126 138 - T 21-04-2016 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 SMART SM00220 15 252 2.3E-40 T 21-04-2016 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 Pfam PF00069 Protein kinase domain 15 245 4.6E-38 T 21-04-2016 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 PANTHER PTHR24362 15 250 1.9E-46 T 21-04-2016 SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 SUPERFAMILY SSF56112 14 248 8.77E-50 T 21-04-2016 IPR011009 Protein kinase-like domain SPH21_RS24375 7a0df084d8777afc8ce4acb842b20592 593 Gene3D G3DSA:1.10.510.10 117 257 5.8E-28 T 21-04-2016 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 4 59 9.9E-8 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 SUPERFAMILY SSF54292 2 77 3.93E-27 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 38 46 - T 21-04-2016 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 PANTHER PTHR11908 1 133 7.6E-35 T 21-04-2016 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 PANTHER PTHR11908:SF66 1 133 7.6E-35 T 21-04-2016 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 Pfam PF01799 [2Fe-2S] binding domain 72 143 1.5E-27 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 Gene3D G3DSA:3.10.20.30 2 73 1.7E-30 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 SUPERFAMILY SSF47741 72 151 4.84E-31 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS23440 c3e3188815a1556f313edefc2b1f0f5d 156 Gene3D G3DSA:1.10.150.120 74 152 5.9E-31 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS06705 249b4269a473f127cdae305a50c7127b 190 SUPERFAMILY SSF55469 7 189 3.4E-32 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS06705 249b4269a473f127cdae305a50c7127b 190 PANTHER PTHR23026 1 188 3.3E-41 T 21-04-2016 SPH21_RS06705 249b4269a473f127cdae305a50c7127b 190 PANTHER PTHR23026:SF104 1 188 3.3E-41 T 21-04-2016 SPH21_RS06705 249b4269a473f127cdae305a50c7127b 190 Pfam PF00881 Nitroreductase family 11 168 2.6E-25 T 21-04-2016 IPR029479 Nitroreductase SPH21_RS06705 249b4269a473f127cdae305a50c7127b 190 Gene3D G3DSA:3.40.109.10 7 189 2.5E-38 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS13015 031bd9d3a5cce13655291a5a04ec7c46 198 SUPERFAMILY SSF52218 1 185 3.55E-52 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS13015 031bd9d3a5cce13655291a5a04ec7c46 198 Pfam PF02525 Flavodoxin-like fold 1 195 1.1E-45 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS13015 031bd9d3a5cce13655291a5a04ec7c46 198 PANTHER PTHR10204 1 192 2.2E-48 T 21-04-2016 SPH21_RS13015 031bd9d3a5cce13655291a5a04ec7c46 198 Gene3D G3DSA:3.40.50.360 1 193 2.9E-62 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS13015 031bd9d3a5cce13655291a5a04ec7c46 198 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 1 196 27.414 T 21-04-2016 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 SPH21_RS13015 031bd9d3a5cce13655291a5a04ec7c46 198 PANTHER PTHR10204:SF16 1 192 2.2E-48 T 21-04-2016 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 PIRSF PIRSF004762 11 385 5.4E-103 T 21-04-2016 IPR005244 FO synthase, subunit 2-like GO:0016765|GO:0051188|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198|UniPathway: UPA00072 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 SUPERFAMILY SSF102114 31 364 9.55E-41 T 21-04-2016 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 Gene3D G3DSA:3.20.20.70 31 364 5.2E-50 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 PANTHER PTHR22976:SF4 17 398 3.2E-136 T 21-04-2016 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 TIGRFAM TIGR03700 mena_SCO4494: putative menaquinone biosynthesis radical SAM enzyme, SCO4494 family 24 374 1.5E-135 T 21-04-2016 IPR022432 Aminodeoxyfutalosine synthase GO:0009234 KEGG: 00130+2.5.1.120|MetaCyc: PWY-7371|MetaCyc: PWY-7374|UniPathway: UPA00079 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 Pfam PF04055 Radical SAM superfamily 74 244 2.8E-12 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 Hamap MF_00993 Aminodeoxyfutalosine synthase [mqnE]. 20 377 48.422 T 21-04-2016 IPR022432 Aminodeoxyfutalosine synthase GO:0009234 KEGG: 00130+2.5.1.120|MetaCyc: PWY-7371|MetaCyc: PWY-7374|UniPathway: UPA00079 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 67 373 2.6E-100 T 21-04-2016 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198|UniPathway: UPA00072 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 PANTHER PTHR22976 17 398 3.2E-136 T 21-04-2016 SPH21_RS16825 458368caf4e2260184b5ac3d2867b054 398 SMART SM00729 70 288 0.0056 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS01160 c4a80b3bdebdc8219ba0146cc1c7f0b9 343 Pfam PF06067 Domain of unknown function (DUF932) 84 315 4.8E-60 T 21-04-2016 IPR026325 Protein of unknown function DUF932 SPH21_RS01160 c4a80b3bdebdc8219ba0146cc1c7f0b9 343 TIGRFAM TIGR03299 LGT_TIGR03299: phage/plasmid-like protein TIGR03299 16 329 7.3E-59 T 21-04-2016 IPR017686 Phage/plasmid-like protein SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 PANTHER PTHR32479 46 459 2.1E-142 T 21-04-2016 SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 312 323 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 Gene3D G3DSA:3.40.50.10420 188 294 2.5E-42 T 21-04-2016 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 Gene3D G3DSA:3.40.50.10420 63 127 2.5E-42 T 21-04-2016 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 Pfam PF13183 4Fe-4S dicluster domain 311 376 1.5E-10 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 SUPERFAMILY SSF100950 134 294 5.44E-36 T 21-04-2016 SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 SUPERFAMILY SSF100950 63 88 5.44E-36 T 21-04-2016 SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 70 293 4.6E-42 T 21-04-2016 IPR003741 LUD domain SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 TIGRFAM TIGR00273 TIGR00273: iron-sulfur cluster-binding protein 40 427 3.5E-137 T 21-04-2016 IPR004452 4Fe-4S binding protein GO:0019516 SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 Gene3D G3DSA:1.10.1060.10 302 396 9.0E-12 T 21-04-2016 SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 SUPERFAMILY SSF46548 269 393 1.67E-16 T 21-04-2016 IPR009051 Alpha-helical ferredoxin GO:0051536 SPH21_RS00085 20556ab3a522d28f7610e9bbcc07b04e 462 PANTHER PTHR32479:SF10 46 459 2.1E-142 T 21-04-2016 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PANTHER PTHR11444 8 394 4.9E-120 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 ProSitePatterns PS00163 Fumarate lyases signature. 276 285 - T 21-04-2016 IPR020557 Fumarate lyase, conserved site GO:0003824 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00145 Argininosuccinate lyase family signature 276 292 4.7E-35 T 21-04-2016 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00145 Argininosuccinate lyase family signature 193 209 4.7E-35 T 21-04-2016 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00145 Argininosuccinate lyase family signature 142 162 4.7E-35 T 21-04-2016 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00145 Argininosuccinate lyase family signature 101 123 4.7E-35 T 21-04-2016 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00145 Argininosuccinate lyase family signature 311 330 4.7E-35 T 21-04-2016 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 SUPERFAMILY SSF48557 19 394 4.71E-98 T 21-04-2016 IPR008948 L-Aspartase-like GO:0003824 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00149 Fumarate lyase superfamily signature 102 120 5.0E-17 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00149 Fumarate lyase superfamily signature 276 292 5.0E-17 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PRINTS PR00149 Fumarate lyase superfamily signature 147 165 5.0E-17 T 21-04-2016 IPR000362 Fumarate lyase family SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 Hamap MF_00006 Argininosuccinate lyase [argH]. 2 443 29.324 T 21-04-2016 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 TIGRFAM TIGR00838 argH: argininosuccinate lyase 9 405 2.1E-102 T 21-04-2016 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 Gene3D G3DSA:1.20.200.10 107 385 3.6E-68 T 21-04-2016 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 Pfam PF00206 Lyase 24 300 9.4E-46 T 21-04-2016 IPR022761 Fumarate lyase, N-terminal SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 PANTHER PTHR11444:SF3 8 394 4.9E-120 T 21-04-2016 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05120 06993a92f85ddb1bd783b7daaec1ae2d 443 Gene3D G3DSA:1.10.275.10 1 106 6.4E-30 T 21-04-2016 IPR024083 Fumarase/histidase, N-terminal SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 PANTHER PTHR22604 1 210 1.7E-109 T 21-04-2016 SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 PANTHER PTHR22604 227 442 1.7E-109 T 21-04-2016 SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 Gene3D G3DSA:3.40.50.720 33 188 5.3E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 Gene3D G3DSA:3.30.360.10 379 433 1.8E-28 T 21-04-2016 SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 Gene3D G3DSA:3.30.360.10 189 345 1.8E-28 T 21-04-2016 SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 PANTHER PTHR22604:SF122 1 210 1.7E-109 T 21-04-2016 SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 PANTHER PTHR22604:SF122 227 442 1.7E-109 T 21-04-2016 SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 5 27 5.9E-4 T 21-04-2016 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 SUPERFAMILY SSF51735 29 206 1.19E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 38 175 4.0E-19 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS14175 995aa221c39da12643d8b31e20a595b9 459 SUPERFAMILY SSF55347 184 370 1.55E-21 T 21-04-2016 SPH21_RS02170 e7415749e7ac1e6854e8d3547897466a 152 Gene3D G3DSA:3.40.50.1010 1 141 2.2E-11 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS02170 e7415749e7ac1e6854e8d3547897466a 152 Pfam PF01850 PIN domain 4 135 3.5E-10 T 21-04-2016 IPR002716 PIN domain SPH21_RS02170 e7415749e7ac1e6854e8d3547897466a 152 SUPERFAMILY SSF88723 1 139 1.96E-15 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 Pfam PF01966 HD domain 334 424 4.3E-18 T 21-04-2016 IPR006674 HD domain SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 TIGRFAM TIGR03319 RNase_Y: ribonuclease Y 5 517 2.3E-200 T 21-04-2016 IPR017705 Ribonuclease Y GO:0003723|GO:0006402|GO:0016020 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 SUPERFAMILY SSF109604 306 467 5.07E-28 T 21-04-2016 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 Pfam PF00013 KH domain 218 264 1.4E-6 T 21-04-2016 IPR004088 K Homology domain, type 1 GO:0003723 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 TIGRFAM TIGR00277 HDIG: HDIG domain 329 405 1.3E-20 T 21-04-2016 IPR006675 HDIG domain SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 Hamap MF_00335 Ribonuclease Y [rny]. 2 517 23.555 T 21-04-2016 IPR017705 Ribonuclease Y GO:0003723|GO:0006402|GO:0016020 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 PANTHER PTHR12826 204 516 1.7E-125 T 21-04-2016 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 Gene3D G3DSA:1.10.3210.10 313 492 1.0E-42 T 21-04-2016 IPR006674 HD domain SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 Gene3D G3DSA:3.30.1370.10 216 278 3.7E-6 T 21-04-2016 IPR004088 K Homology domain, type 1 GO:0003723 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 SUPERFAMILY SSF54791 204 293 1.38E-15 T 21-04-2016 IPR004088 K Homology domain, type 1 GO:0003723 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 Pfam PF12072 Domain of unknown function (DUF3552) 3 201 3.5E-40 T 21-04-2016 IPR022711 Ribonuclease Y, N-terminal SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 ProDom PD936484 POLYPROTEIN GLYCOPROTEIN M G2 TRANSMEMBRANE NONSTRUCTURAL MEMBRANE CONTAINS: PRECURSOR SIGNAL 24 200 4.0E-5 T 21-04-2016 SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 SMART SM00471 329 435 2.5E-11 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS19620 8fe0c2b9517bcc5bd50608475304c1fb 517 SMART SM00322 205 275 6.6E-5 T 21-04-2016 IPR004087 K Homology domain GO:0003676 SPH21_RS14860 c3e200827e5d33fd711f2a029550d67c 223 Gene3D G3DSA:1.25.40.10 40 208 1.5E-17 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14860 c3e200827e5d33fd711f2a029550d67c 223 PANTHER PTHR23083 32 192 3.3E-12 T 21-04-2016 SPH21_RS14860 c3e200827e5d33fd711f2a029550d67c 223 Pfam PF13174 Tetratricopeptide repeat 75 104 0.005 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS14860 c3e200827e5d33fd711f2a029550d67c 223 SUPERFAMILY SSF48452 38 167 1.71E-15 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 Gene3D G3DSA:1.10.490.10 1 141 5.5E-50 T 21-04-2016 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 PRINTS PR00410 Phenol hydroxylase reductase family signature 184 196 1.8E-9 T 21-04-2016 IPR001221 Phenol hydroxylase reductase GO:0055114 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 PRINTS PR00410 Phenol hydroxylase reductase family signature 361 369 1.8E-9 T 21-04-2016 IPR001221 Phenol hydroxylase reductase GO:0055114 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 PRINTS PR00410 Phenol hydroxylase reductase family signature 269 288 1.8E-9 T 21-04-2016 IPR001221 Phenol hydroxylase reductase GO:0055114 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 Gene3D G3DSA:2.40.30.10 150 260 1.3E-31 T 21-04-2016 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 PANTHER PTHR22924:SF49 8 395 9.4E-115 T 21-04-2016 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 SUPERFAMILY SSF52343 263 397 5.37E-31 T 21-04-2016 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 Pfam PF00175 Oxidoreductase NAD-binding domain 270 372 5.7E-14 T 21-04-2016 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 SUPERFAMILY SSF63380 150 260 1.11E-25 T 21-04-2016 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 Pfam PF00970 Oxidoreductase FAD-binding domain 156 258 7.9E-6 T 21-04-2016 IPR008333 Oxidoreductase, FAD-binding domain SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 Gene3D G3DSA:3.40.50.80 261 396 9.1E-29 T 21-04-2016 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 PANTHER PTHR22924 8 395 9.4E-115 T 21-04-2016 SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 SUPERFAMILY SSF46458 1 142 1.01E-39 T 21-04-2016 IPR009050 Globin-like SPH21_RS12450 52fd954ac2615897e13ca17cf0600abd 401 Pfam PF00042 Globin 5 101 1.0E-11 T 21-04-2016 IPR000971 Globin GO:0019825|GO:0020037 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 SUPERFAMILY SSF55874 124 286 1.1E-35 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 Gene3D G3DSA:1.10.287.130 64 120 5.1E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 PANTHER PTHR24423 67 286 1.3E-58 T 21-04-2016 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 PRINTS PR00344 Bacterial sensor protein C-terminal signature 250 268 1.1E-9 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 PRINTS PR00344 Bacterial sensor protein C-terminal signature 215 229 1.1E-9 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 PRINTS PR00344 Bacterial sensor protein C-terminal signature 233 243 1.1E-9 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 Pfam PF00512 His Kinase A (phospho-acceptor) domain 70 133 4.3E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 Gene3D G3DSA:3.30.565.10 121 286 4.0E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 SMART SM00388 68 134 1.1E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 SUPERFAMILY SSF47384 54 133 2.75E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 178 285 2.5E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25570 60b037e727a62e951128d61133e6d493 287 SMART SM00387 178 287 5.6E-27 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24115 d1820b51f9ae2dd18cb2791d5d73cf57 363 PANTHER PTHR23024 114 363 9.3E-55 T 21-04-2016 SPH21_RS24115 d1820b51f9ae2dd18cb2791d5d73cf57 363 Pfam PF07859 alpha/beta hydrolase fold 130 336 5.1E-50 T 21-04-2016 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SPH21_RS24115 d1820b51f9ae2dd18cb2791d5d73cf57 363 SUPERFAMILY SSF53474 80 363 4.3E-49 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24115 d1820b51f9ae2dd18cb2791d5d73cf57 363 PANTHER PTHR23024:SF24 114 363 9.3E-55 T 21-04-2016 SPH21_RS24115 d1820b51f9ae2dd18cb2791d5d73cf57 363 Gene3D G3DSA:3.40.50.1820 45 363 3.4E-69 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS20905 59a8039167d909ed274c0a4cf83c4b85 355 PANTHER PTHR32487 1 355 2.5E-117 T 21-04-2016 SPH21_RS20905 59a8039167d909ed274c0a4cf83c4b85 355 SUPERFAMILY SSF51735 3 273 1.81E-28 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20905 59a8039167d909ed274c0a4cf83c4b85 355 Gene3D G3DSA:3.40.50.720 2 255 2.3E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20905 59a8039167d909ed274c0a4cf83c4b85 355 PANTHER PTHR32487:SF0 1 355 2.5E-117 T 21-04-2016 SPH21_RS20905 59a8039167d909ed274c0a4cf83c4b85 355 Pfam PF01370 NAD dependent epimerase/dehydratase family 5 234 6.6E-11 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS03175 7d630238d235ae8dcb175d7c1b76fef2 325 PANTHER PTHR22604 5 320 9.6E-59 T 21-04-2016 SPH21_RS03175 7d630238d235ae8dcb175d7c1b76fef2 325 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 5 125 2.7E-24 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS03175 7d630238d235ae8dcb175d7c1b76fef2 325 Gene3D G3DSA:3.30.360.10 140 321 2.0E-24 T 21-04-2016 SPH21_RS03175 7d630238d235ae8dcb175d7c1b76fef2 325 SUPERFAMILY SSF51735 3 153 7.58E-45 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03175 7d630238d235ae8dcb175d7c1b76fef2 325 SUPERFAMILY SSF55347 131 289 3.43E-23 T 21-04-2016 SPH21_RS03175 7d630238d235ae8dcb175d7c1b76fef2 325 Gene3D G3DSA:3.40.50.720 2 139 9.3E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 SUPERFAMILY SSF51338 27 83 1.62E-17 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 SUPERFAMILY SSF51338 407 440 1.62E-17 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 Gene3D G3DSA:2.30.40.10 422 446 6.3E-24 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 Gene3D G3DSA:2.30.40.10 27 84 6.3E-24 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 Gene3D G3DSA:2.30.40.10 390 421 1.5E-8 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 Gene3D G3DSA:3.20.20.140 85 389 6.0E-54 T 21-04-2016 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 PANTHER PTHR11271 31 305 3.8E-24 T 21-04-2016 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 PANTHER PTHR11271 336 444 3.8E-24 T 21-04-2016 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 Pfam PF01979 Amidohydrolase family 79 444 2.3E-26 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 SUPERFAMILY SSF51556 335 408 1.93E-49 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 SUPERFAMILY SSF51556 82 307 1.93E-49 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 PANTHER PTHR11271:SF33 31 305 3.8E-24 T 21-04-2016 SPH21_RS09470 ee04815acd6ee70562b00f31b1179f9f 446 PANTHER PTHR11271:SF33 336 444 3.8E-24 T 21-04-2016 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 Pfam PF00171 Aldehyde dehydrogenase family 61 513 6.3E-102 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 PANTHER PTHR11699 23 544 1.1E-266 T 21-04-2016 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 TIGRFAM TIGR01236 D1pyr5carbox1: 1-pyrroline-5-carboxylate dehydrogenase 13 540 4.9E-245 T 21-04-2016 IPR005931 Delta-1-pyrroline-5-carboxylate dehydrogenase GO:0003842|GO:0006537|GO:0006561 KEGG: 00250+1.2.1.88|KEGG: 00330+1.2.1.88|MetaCyc: PWY-6853|UniPathway: UPA00261 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 SUPERFAMILY SSF53720 8 527 1.96E-122 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 Gene3D G3DSA:3.40.309.10 308 500 1.4E-49 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 Gene3D G3DSA:3.40.605.10 43 307 8.8E-61 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 321 332 - T 21-04-2016 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 293 300 - T 21-04-2016 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SPH21_RS01710 e299e60f3857a7b2a25206eedca1cd80 544 PANTHER PTHR11699:SF18 23 544 1.1E-266 T 21-04-2016 SPH21_RS03025 a8da23b9b9f850e270effb3f1a3288b2 357 PANTHER PTHR13748 4 176 2.8E-18 T 21-04-2016 SPH21_RS03025 a8da23b9b9f850e270effb3f1a3288b2 357 SUPERFAMILY SSF52540 5 204 5.16E-22 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03025 a8da23b9b9f850e270effb3f1a3288b2 357 Gene3D G3DSA:3.40.50.300 3 187 3.9E-27 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03025 a8da23b9b9f850e270effb3f1a3288b2 357 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 5 183 2.0E-27 T 21-04-2016 IPR003495 CobW/HypB/UreG, nucleotide-binding domain SPH21_RS16375 93c9255c368651ad36da98d40f3bd1f8 191 Gene3D G3DSA:2.60.120.10 9 156 8.2E-29 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS16375 93c9255c368651ad36da98d40f3bd1f8 191 SMART SM00100 12 133 0.0036 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS16375 93c9255c368651ad36da98d40f3bd1f8 191 PANTHER PTHR24567 20 191 1.3E-30 T 21-04-2016 SPH21_RS16375 93c9255c368651ad36da98d40f3bd1f8 191 Pfam PF00027 Cyclic nucleotide-binding domain 31 118 1.5E-11 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS16375 93c9255c368651ad36da98d40f3bd1f8 191 SUPERFAMILY SSF51206 21 140 2.49E-21 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS16375 93c9255c368651ad36da98d40f3bd1f8 191 PANTHER PTHR24567:SF33 20 191 1.3E-30 T 21-04-2016 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 SUPERFAMILY SSF51215 25 158 2.62E-8 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 PANTHER PTHR11019 26 98 1.2E-26 T 21-04-2016 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 PANTHER PTHR11019 119 283 1.2E-26 T 21-04-2016 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 Gene3D G3DSA:1.10.10.60 235 280 3.1E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 Gene3D G3DSA:2.60.120.280 28 158 1.8E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 SUPERFAMILY SSF46689 229 278 2.51E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 SMART SM00342 192 275 2.2E-23 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 Gene3D G3DSA:1.10.10.60 171 228 4.1E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 229 271 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 Pfam PF02311 AraC-like ligand binding domain 25 81 2.2E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21890 c9ef2fb7f7b02ca2fc42d5c4b99fdebf 290 Pfam PF12833 Helix-turn-helix domain 198 277 4.3E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 1.8E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 219 239 1.8E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 1.8E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 1.8E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 1.8E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 16 33 1.8E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 23 256 7.4E-48 T 21-04-2016 SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 146 174 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 SUPERFAMILY SSF51735 15 257 5.01E-65 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 7.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 7.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 7.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 Gene3D G3DSA:3.40.50.720 14 257 2.1E-65 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PANTHER PTHR24322 159 191 7.6E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24180 85ca5c8fb3c354cf85d253d3efa1a161 258 PANTHER PTHR24322 19 143 7.6E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS13370 e0329e15dc4303882aa71296c627ea67 172 Pfam PF00355 Rieske [2Fe-2S] domain 70 156 1.6E-15 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS13370 e0329e15dc4303882aa71296c627ea67 172 PRINTS PR00162 Rieske 2Fe-2S subunit signature 128 140 1.9E-5 T 21-04-2016 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SPH21_RS13370 e0329e15dc4303882aa71296c627ea67 172 PRINTS PR00162 Rieske 2Fe-2S subunit signature 141 153 1.9E-5 T 21-04-2016 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SPH21_RS13370 e0329e15dc4303882aa71296c627ea67 172 PRINTS PR00162 Rieske 2Fe-2S subunit signature 107 118 1.9E-5 T 21-04-2016 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SPH21_RS13370 e0329e15dc4303882aa71296c627ea67 172 SUPERFAMILY SSF50022 30 167 9.43E-30 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS13370 e0329e15dc4303882aa71296c627ea67 172 Gene3D G3DSA:2.102.10.10 29 167 3.4E-29 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS18385 86453cc9af6be741a5795a5844377021 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS18385 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258:SF1 7 352 2.4E-48 T 21-04-2016 SPH21_RS18385 86453cc9af6be741a5795a5844377021 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS18385 86453cc9af6be741a5795a5844377021 398 Pfam PF14294 Domain of unknown function (DUF4372) 9 81 3.8E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS18385 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258 7 352 2.4E-48 T 21-04-2016 SPH21_RS18385 86453cc9af6be741a5795a5844377021 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS20045 86453cc9af6be741a5795a5844377021 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS20045 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258:SF1 7 352 2.4E-48 T 21-04-2016 SPH21_RS20045 86453cc9af6be741a5795a5844377021 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS20045 86453cc9af6be741a5795a5844377021 398 Pfam PF14294 Domain of unknown function (DUF4372) 9 81 3.8E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS20045 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258 7 352 2.4E-48 T 21-04-2016 SPH21_RS20045 86453cc9af6be741a5795a5844377021 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS10105 86453cc9af6be741a5795a5844377021 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS10105 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258:SF1 7 352 2.4E-48 T 21-04-2016 SPH21_RS10105 86453cc9af6be741a5795a5844377021 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS10105 86453cc9af6be741a5795a5844377021 398 Pfam PF14294 Domain of unknown function (DUF4372) 9 81 3.8E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS10105 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258 7 352 2.4E-48 T 21-04-2016 SPH21_RS10105 86453cc9af6be741a5795a5844377021 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS02505 86453cc9af6be741a5795a5844377021 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS02505 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258:SF1 7 352 2.4E-48 T 21-04-2016 SPH21_RS02505 86453cc9af6be741a5795a5844377021 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS02505 86453cc9af6be741a5795a5844377021 398 Pfam PF14294 Domain of unknown function (DUF4372) 9 81 3.8E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS02505 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258 7 352 2.4E-48 T 21-04-2016 SPH21_RS02505 86453cc9af6be741a5795a5844377021 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS22800 86453cc9af6be741a5795a5844377021 398 Pfam PF01609 Transposase DDE domain 126 338 2.8E-29 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS22800 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258:SF1 7 352 2.4E-48 T 21-04-2016 SPH21_RS22800 86453cc9af6be741a5795a5844377021 398 Gene3D G3DSA:3.90.350.10 289 314 1.3E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS22800 86453cc9af6be741a5795a5844377021 398 Pfam PF14294 Domain of unknown function (DUF4372) 9 81 3.8E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS22800 86453cc9af6be741a5795a5844377021 398 PANTHER PTHR33258 7 352 2.4E-48 T 21-04-2016 SPH21_RS22800 86453cc9af6be741a5795a5844377021 398 SUPERFAMILY SSF53098 129 353 3.87E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS16765 0d0e372d9a88cb73d50866484aa42c6c 314 Pfam PF01841 Transglutaminase-like superfamily 137 234 6.1E-22 T 21-04-2016 IPR002931 Transglutaminase-like SPH21_RS16765 0d0e372d9a88cb73d50866484aa42c6c 314 PANTHER PTHR33490:SF6 1 277 2.2E-49 T 21-04-2016 SPH21_RS16765 0d0e372d9a88cb73d50866484aa42c6c 314 Pfam PF08379 Bacterial transglutaminase-like N-terminal region 4 81 6.7E-17 T 21-04-2016 IPR013589 Bacterial transglutaminase-like, N-terminal SPH21_RS16765 0d0e372d9a88cb73d50866484aa42c6c 314 PANTHER PTHR33490 1 277 2.2E-49 T 21-04-2016 SPH21_RS16765 0d0e372d9a88cb73d50866484aa42c6c 314 SUPERFAMILY SSF54001 8 263 1.2E-38 T 21-04-2016 SPH21_RS16765 0d0e372d9a88cb73d50866484aa42c6c 314 SMART SM00460 170 236 7.2E-18 T 21-04-2016 IPR002931 Transglutaminase-like SPH21_RS16765 0d0e372d9a88cb73d50866484aa42c6c 314 Gene3D G3DSA:3.90.260.10 174 265 3.1E-15 T 21-04-2016 IPR002931 Transglutaminase-like SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 Pfam PF16326 ABC transporter C-terminal domain 546 610 1.9E-11 T 21-04-2016 IPR032524 ABC transporter Uup, C-terminal GO:0003677 SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 PANTHER PTHR19211 4 564 2.6E-168 T 21-04-2016 SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 Gene3D G3DSA:3.40.50.300 311 545 8.2E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 Gene3D G3DSA:3.40.50.300 5 275 3.7E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 ProSitePatterns PS00211 ABC transporters family signature. 153 167 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 Pfam PF00005 ABC transporter 20 181 1.1E-27 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 Pfam PF00005 ABC transporter 330 464 3.0E-22 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 SUPERFAMILY SSF52540 4 233 3.98E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 Pfam PF12848 ABC transporter 221 300 6.5E-10 T 21-04-2016 IPR032781 ABC-transporter extension domain SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 SMART SM00382 338 508 8.2E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 SMART SM00382 28 225 1.8E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS06405 88e1fa5e01f7e1d6e737076999eb026a 613 SUPERFAMILY SSF52540 305 510 8.89E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 Gene3D G3DSA:3.40.50.1240 5 204 2.7E-47 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 5 196 4.5E-51 T 21-04-2016 IPR013078 Histidine phosphatase superfamily, clade-1 SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 SUPERFAMILY SSF53254 1 203 9.62E-45 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 SMART SM00855 4 159 1.2E-15 T 21-04-2016 IPR013078 Histidine phosphatase superfamily, clade-1 SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 7 16 - T 21-04-2016 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 UniPathway: UPA00109 SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 PANTHER PTHR23029:SF1 6 204 3.9E-42 T 21-04-2016 SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 PIRSF PIRSF000709 1 201 1.4E-13 T 21-04-2016 SPH21_RS16820 2e799573ca60687e78a6260114ac4f07 209 PANTHER PTHR23029 6 204 3.9E-42 T 21-04-2016 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 PANTHER PTHR11236 1 469 4.0E-152 T 21-04-2016 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 PRINTS PR00095 Anthranilate synthase component I signature 319 332 1.3E-16 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 PRINTS PR00095 Anthranilate synthase component I signature 412 426 1.3E-16 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 PRINTS PR00095 Anthranilate synthase component I signature 305 318 1.3E-16 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 PRINTS PR00095 Anthranilate synthase component I signature 397 411 1.3E-16 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 SUPERFAMILY SSF56322 7 464 4.45E-129 T 21-04-2016 IPR005801 ADC synthase GO:0009058 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 Gene3D G3DSA:3.60.120.10 4 468 2.5E-135 T 21-04-2016 IPR005801 ADC synthase GO:0009058 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 PANTHER PTHR11236:SF9 1 469 4.0E-152 T 21-04-2016 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 Pfam PF04715 Anthranilate synthase component I, N terminal region 16 162 4.9E-22 T 21-04-2016 IPR006805 Anthranilate synthase component I, N-terminal GO:0009058|GO:0016833 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS07430 ef2e5940d630f0562a162d95c794041a 469 Pfam PF00425 chorismate binding enzyme 204 455 2.0E-82 T 21-04-2016 IPR015890 Chorismate-utilising enzyme, C-terminal SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 Pfam PF00106 short chain dehydrogenase 3 187 6.1E-47 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 135 163 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 2.7E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 2.7E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 2.7E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 2.7E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 122 138 2.7E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 SUPERFAMILY SSF51735 3 235 5.14E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 2.7E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 2.7E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 128 136 2.7E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PANTHER PTHR24322:SF363 148 179 2.8E-46 T 21-04-2016 SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PANTHER PTHR24322:SF363 7 132 2.8E-46 T 21-04-2016 SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 Gene3D G3DSA:3.40.50.720 2 243 4.2E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PANTHER PTHR24322 148 179 2.8E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24570 60c7a2ecf49a11bce7c4f06702ffc672 274 PANTHER PTHR24322 7 132 2.8E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 SUPERFAMILY SSF46894 129 228 1.02E-27 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 SMART SM00862 153 228 1.1E-21 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 PANTHER PTHR26402:SF578 3 230 3.8E-90 T 21-04-2016 SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 SMART SM00448 3 114 2.1E-40 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 SUPERFAMILY SSF52172 3 127 2.7E-38 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 Pfam PF00486 Transcriptional regulatory protein, C terminal 153 227 1.0E-22 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 Gene3D G3DSA:3.40.50.2300 3 129 1.3E-38 T 21-04-2016 SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 Gene3D G3DSA:1.10.10.10 131 229 7.9E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 Pfam PF00072 Response regulator receiver domain 5 115 2.1E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS19740 ebd14857d4f20ccb9dc52d1d0b3e5f0c 231 PANTHER PTHR26402 3 230 3.8E-90 T 21-04-2016 SPH21_RS03330 0b29c60ad41aea4f2d60f89f1f20d604 442 SUPERFAMILY SSF50182 201 268 7.52E-13 T 21-04-2016 IPR010920 LSM domain SPH21_RS03330 0b29c60ad41aea4f2d60f89f1f20d604 442 PANTHER PTHR30414:SF0 12 432 6.8E-150 T 21-04-2016 IPR030192 Miniconductance mechanosensitive channel YbdG GO:0008381|GO:0016021|GO:0071470 SPH21_RS03330 0b29c60ad41aea4f2d60f89f1f20d604 442 PANTHER PTHR30414 12 432 6.8E-150 T 21-04-2016 SPH21_RS03330 0b29c60ad41aea4f2d60f89f1f20d604 442 Gene3D G3DSA:2.30.30.60 218 268 9.1E-11 T 21-04-2016 SPH21_RS03330 0b29c60ad41aea4f2d60f89f1f20d604 442 Pfam PF00924 Mechanosensitive ion channel 158 413 1.1E-46 T 21-04-2016 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 2.5E-22 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 SUPERFAMILY SSF46785 1 87 1.59E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 Gene3D G3DSA:1.10.10.10 1 86 2.8E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 Pfam PF03466 LysR substrate binding domain 87 283 1.1E-37 T 21-04-2016 IPR005119 LysR, substrate-binding SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 PANTHER PTHR30346 1 282 1.6E-81 T 21-04-2016 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 Gene3D G3DSA:3.40.190.10 187 257 8.7E-18 T 21-04-2016 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 SUPERFAMILY SSF53850 89 282 7.45E-35 T 21-04-2016 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 Gene3D G3DSA:3.40.190.10 89 186 3.7E-19 T 21-04-2016 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.1E-10 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.1E-10 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS14015 b91197b7044aa977fd2f58fde6e77ea1 290 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.1E-10 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS16040 9de33b47d1afb195df571afca9229094 275 SUPERFAMILY SSF55021 177 269 2.43E-18 T 21-04-2016 SPH21_RS16040 9de33b47d1afb195df571afca9229094 275 Gene3D G3DSA:3.40.190.10 2 91 3.5E-25 T 21-04-2016 SPH21_RS16040 9de33b47d1afb195df571afca9229094 275 Gene3D G3DSA:3.40.190.10 92 170 2.2E-25 T 21-04-2016 SPH21_RS16040 9de33b47d1afb195df571afca9229094 275 PANTHER PTHR21022 1 272 3.2E-83 T 21-04-2016 SPH21_RS16040 9de33b47d1afb195df571afca9229094 275 Gene3D G3DSA:3.30.70.260 187 269 9.3E-20 T 21-04-2016 SPH21_RS16040 9de33b47d1afb195df571afca9229094 275 SUPERFAMILY SSF53850 5 187 3.36E-52 T 21-04-2016 SPH21_RS16040 9de33b47d1afb195df571afca9229094 275 Pfam PF00800 Prephenate dehydratase 6 184 5.3E-56 T 21-04-2016 IPR001086 Prephenate dehydratase GO:0004664|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432|UniPathway: UPA00121 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 PRINTS PR00974 Ribosomal protein S18 family signature 49 56 1.2E-17 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 PRINTS PR00974 Ribosomal protein S18 family signature 57 71 1.2E-17 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 PRINTS PR00974 Ribosomal protein S18 family signature 71 81 1.2E-17 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 PRINTS PR00974 Ribosomal protein S18 family signature 39 49 1.2E-17 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 SUPERFAMILY SSF46911 15 84 7.32E-28 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 PANTHER PTHR13479 18 83 1.0E-26 T 21-04-2016 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 Pfam PF01084 Ribosomal protein S18 29 79 7.9E-24 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 TIGRFAM TIGR00165 S18: ribosomal protein bS18 17 84 1.1E-30 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 Hamap MF_00270 30S ribosomal protein S18 [rpsR]. 13 84 20.844 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 ProDom PD002239 RIBOSOMAL S18 RIBONUCLEOPROTEIN 30S RRNA-BINDING RNA-BINDING CHLOROPLAST PLASTID MITOCHONDRIAL ACETYLATION 31 82 2.0E-19 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11600 0e2e58f55242b27da41c263763c33dae 87 Gene3D G3DSA:4.10.640.10 19 85 3.6E-32 T 21-04-2016 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF07676 WD40-like Beta Propeller Repeat 357 392 4.1E-5 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF07676 WD40-like Beta Propeller Repeat 66 99 1.4E-6 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF07676 WD40-like Beta Propeller Repeat 414 441 0.0015 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF07676 WD40-like Beta Propeller Repeat 219 252 0.0054 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF07676 WD40-like Beta Propeller Repeat 35 47 0.066 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF07676 WD40-like Beta Propeller Repeat 331 345 0.11 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 PANTHER PTHR32060 719 1089 1.7E-53 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF03572 Peptidase family S41 910 1066 1.2E-17 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SUPERFAMILY SSF52096 720 796 1.16E-55 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SUPERFAMILY SSF52096 883 1089 1.16E-55 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SUPERFAMILY SSF82171 34 112 1.92E-40 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SUPERFAMILY SSF82171 166 260 1.92E-40 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SUPERFAMILY SSF82171 331 536 1.92E-40 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Gene3D G3DSA:3.30.750.44 719 784 6.6E-28 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Gene3D G3DSA:2.120.10.60 26 305 8.3E-64 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Gene3D G3DSA:3.90.226.10 891 1089 6.4E-34 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Gene3D G3DSA:2.120.10.30 322 392 1.5E-13 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Gene3D G3DSA:2.120.10.30 403 547 3.8E-33 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Gene3D G3DSA:2.120.10.30 619 711 3.8E-33 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SMART SM00245 872 1067 2.8E-4 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 PANTHER PTHR32060:SF12 719 1089 1.7E-53 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Pfam PF14684 Tricorn protease C1 domain 720 786 1.6E-26 T 21-04-2016 IPR028204 Tricorn protease C1 domain SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SUPERFAMILY SSF82171 622 716 2.55E-8 T 21-04-2016 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 SUPERFAMILY SSF50156 802 869 5.38E-9 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 Gene3D G3DSA:2.30.42.10 802 883 7.4E-11 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS18000 340ec46450a7cb514defc8f674330ccf 1090 PIRSF PIRSF036421 20 1090 2.4E-226 T 21-04-2016 IPR012393 Tricorn protease GO:0008236 SPH21_RS05390 f21c677f6c25421f88d32eb4bc326b58 495 SUPERFAMILY SSF48452 27 495 3.67E-87 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05390 f21c677f6c25421f88d32eb4bc326b58 495 Pfam PF14322 Starch-binding associating with outer membrane 32 247 1.4E-29 T 21-04-2016 SPH21_RS05390 f21c677f6c25421f88d32eb4bc326b58 495 Pfam PF07980 SusD family 317 494 1.3E-20 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS05390 f21c677f6c25421f88d32eb4bc326b58 495 Gene3D G3DSA:1.25.40.10 366 447 1.5E-23 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05390 f21c677f6c25421f88d32eb4bc326b58 495 Gene3D G3DSA:1.25.40.10 231 325 1.5E-23 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19585 c0271ccb38edb003b39e2d3e0e97aef2 133 Pfam PF01850 PIN domain 3 122 7.9E-12 T 21-04-2016 IPR002716 PIN domain SPH21_RS19585 c0271ccb38edb003b39e2d3e0e97aef2 133 SUPERFAMILY SSF88723 1 125 5.05E-19 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS19585 c0271ccb38edb003b39e2d3e0e97aef2 133 PANTHER PTHR36173 2 133 1.6E-27 T 21-04-2016 SPH21_RS19585 c0271ccb38edb003b39e2d3e0e97aef2 133 PANTHER PTHR36173:SF2 2 133 1.6E-27 T 21-04-2016 SPH21_RS19585 c0271ccb38edb003b39e2d3e0e97aef2 133 Gene3D G3DSA:3.40.50.1010 1 126 8.6E-8 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS22050 10f990ed7ef85f69643f8ed5e858cd6d 267 SUPERFAMILY SSF56317 1 248 1.57E-39 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS22050 10f990ed7ef85f69643f8ed5e858cd6d 267 Gene3D G3DSA:3.60.110.10 1 248 1.3E-40 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS22050 10f990ed7ef85f69643f8ed5e858cd6d 267 Pfam PF00795 Carbon-nitrogen hydrolase 16 249 1.1E-28 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS22050 10f990ed7ef85f69643f8ed5e858cd6d 267 PANTHER PTHR23088 1 247 5.9E-32 T 21-04-2016 SPH21_RS22050 10f990ed7ef85f69643f8ed5e858cd6d 267 PANTHER PTHR23088:SF5 1 247 5.9E-32 T 21-04-2016 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 SMART SM00028 271 304 0.022 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 SMART SM00028 237 270 410.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 SMART SM00028 138 171 170.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 SMART SM00028 203 236 0.14 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 Pfam PF13429 Tetratricopeptide repeat 201 305 2.5E-6 T 21-04-2016 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 Gene3D G3DSA:1.25.40.10 154 387 3.1E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 Gene3D G3DSA:1.25.40.10 49 89 3.1E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 SUPERFAMILY SSF48452 200 390 2.56E-20 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 SUPERFAMILY SSF48452 144 229 3.1E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 PANTHER PTHR23083 48 121 2.9E-20 T 21-04-2016 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 PANTHER PTHR23083 138 309 2.9E-20 T 21-04-2016 SPH21_RS16745 c6344e0b5e35d772569f5717e844c5cf 395 PANTHER PTHR23083 337 382 2.9E-20 T 21-04-2016 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 Gene3D G3DSA:2.170.130.10 109 236 4.2E-30 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 Pfam PF13715 CarboxypepD_reg-like domain 25 109 3.8E-15 T 21-04-2016 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 Gene3D G3DSA:2.60.40.1120 25 108 3.4E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 PANTHER PTHR32552 99 538 2.7E-101 T 21-04-2016 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 PANTHER PTHR32552 569 850 2.7E-101 T 21-04-2016 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 Pfam PF00593 TonB dependent receptor 576 849 1.1E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 Gene3D G3DSA:2.40.170.20 237 850 4.8E-83 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 SUPERFAMILY SSF49464 23 107 8.76E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 SUPERFAMILY SSF56935 96 850 2.38E-110 T 21-04-2016 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 PANTHER PTHR32552:SF33 99 538 2.7E-101 T 21-04-2016 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 PANTHER PTHR32552:SF33 569 850 2.7E-101 T 21-04-2016 SPH21_RS25135 f000bd0d12756d2c1dc88fe72070d586 855 Pfam PF07715 TonB-dependent Receptor Plug Domain 118 227 3.6E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 SUPERFAMILY SSF56784 460 665 4.34E-51 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 SUPERFAMILY SSF56784 360 379 4.34E-51 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 Pfam PF00122 E1-E2 ATPase 117 352 3.4E-63 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PANTHER PTHR24093:SF317 35 670 6.8E-204 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 SUPERFAMILY SSF81665 262 355 1.57E-18 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 SUPERFAMILY SSF81665 97 149 1.57E-18 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 SUPERFAMILY SSF81665 614 625 1.57E-18 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PANTHER PTHR24093 35 670 6.8E-204 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 252 641 1.2E-65 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 564 580 9.7E-6 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 536 552 9.7E-6 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 Gene3D G3DSA:2.70.150.10 97 262 2.1E-31 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 SUPERFAMILY SSF81653 148 261 6.28E-25 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 Gene3D G3DSA:3.40.1110.10 380 490 5.3E-20 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 195 209 9.1E-25 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 588 600 9.1E-25 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 488 499 9.1E-25 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 511 521 9.1E-25 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 361 375 9.1E-25 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 564 583 9.1E-25 T 21-04-2016 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 Gene3D G3DSA:3.40.1110.10 352 379 5.8E-4 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 95 667 2.3E-174 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 363 369 - T 21-04-2016 IPR018303 P-type ATPase, phosphorylation site SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 Gene3D G3DSA:3.40.50.1000 491 635 1.3E-38 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS18245 497bd9d52a465da143f085bc38ef1282 672 Pfam PF00702 haloacid dehalogenase-like hydrolase 358 574 2.7E-40 T 21-04-2016 SPH21_RS21195 f2f0adaa2501249bbc9f438a3ea408ba 114 Pfam PF04237 YjbR 12 98 6.1E-12 T 21-04-2016 IPR007351 Uncharacterised protein YjbR SPH21_RS21195 f2f0adaa2501249bbc9f438a3ea408ba 114 SUPERFAMILY SSF142906 1 111 1.19E-16 T 21-04-2016 SPH21_RS13735 0b41071f112b2611abbaf7e3a0aaba6a 331 SUPERFAMILY SSF51430 1 325 1.83E-94 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS13735 0b41071f112b2611abbaf7e3a0aaba6a 331 PANTHER PTHR11732 110 322 8.6E-110 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS13735 0b41071f112b2611abbaf7e3a0aaba6a 331 PANTHER PTHR11732 1 93 8.6E-110 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS13735 0b41071f112b2611abbaf7e3a0aaba6a 331 Gene3D G3DSA:3.20.20.100 1 324 4.2E-96 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS13735 0b41071f112b2611abbaf7e3a0aaba6a 331 Pfam PF00248 Aldo/keto reductase family 16 322 9.7E-73 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 TIGRFAM TIGR00706 SppA_dom: signal peptide peptidase SppA, 36K type 319 520 2.7E-61 T 21-04-2016 IPR004635 Peptidase S49, SppA GO:0006508|GO:0008233 SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 SUPERFAMILY SSF52096 198 265 1.6E-27 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 SUPERFAMILY SSF52096 46 167 1.6E-27 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 Gene3D G3DSA:3.90.226.10 450 527 3.1E-64 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 Gene3D G3DSA:3.90.226.10 206 294 6.9E-61 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 Gene3D G3DSA:3.90.226.10 20 163 6.9E-61 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 Gene3D G3DSA:3.90.226.10 304 411 3.1E-64 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 PANTHER PTHR33209 20 542 7.5E-178 T 21-04-2016 SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 SUPERFAMILY SSF52096 304 419 1.16E-42 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 SUPERFAMILY SSF52096 449 509 1.16E-42 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 Pfam PF01343 Peptidase family S49 372 524 9.1E-52 T 21-04-2016 IPR002142 Peptidase S49 GO:0006508|GO:0008233 SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 Pfam PF01343 Peptidase family S49 127 278 2.7E-37 T 21-04-2016 IPR002142 Peptidase S49 GO:0006508|GO:0008233 SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 TIGRFAM TIGR00705 SppA_67K: signal peptide peptidase SppA, 67K type 17 553 6.7E-159 T 21-04-2016 IPR004634 Peptidase S49, protease IV GO:0006465|GO:0008233|GO:0016021 SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 PIRSF PIRSF001217 1 583 1.1E-195 T 21-04-2016 IPR004634 Peptidase S49, protease IV GO:0006465|GO:0008233|GO:0016021 SPH21_RS19960 c12b5681459622aeee5a5789b368f947 588 PANTHER PTHR33209:SF1 20 542 7.5E-178 T 21-04-2016 SPH21_RS22340 6823e16e0516fd776cc3e5a3894c04fc 165 Pfam PF08534 Redoxin 20 161 2.8E-26 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS22340 6823e16e0516fd776cc3e5a3894c04fc 165 Gene3D G3DSA:3.40.30.10 3 165 1.4E-49 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS22340 6823e16e0516fd776cc3e5a3894c04fc 165 PANTHER PTHR10681 4 165 6.9E-50 T 21-04-2016 SPH21_RS22340 6823e16e0516fd776cc3e5a3894c04fc 165 ProSitePatterns PS01265 Tpx family signature. 83 94 - T 21-04-2016 IPR018219 Thiol peroxidase conserved site GO:0016684|GO:0055114 SPH21_RS22340 6823e16e0516fd776cc3e5a3894c04fc 165 Hamap MF_00269 Probable thiol peroxidase [tpx]. 3 165 36.977 T 21-04-2016 IPR002065 Putative thiol peroxidase Tpx GO:0008379|GO:0016209|GO:0055114 SPH21_RS22340 6823e16e0516fd776cc3e5a3894c04fc 165 PANTHER PTHR10681:SF81 4 165 6.9E-50 T 21-04-2016 SPH21_RS22340 6823e16e0516fd776cc3e5a3894c04fc 165 SUPERFAMILY SSF52833 1 162 1.1E-45 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS11550 b74be5a6191e11e9da199beb17b5fd46 386 Pfam PF02515 CoA-transferase family III 4 371 3.0E-96 T 21-04-2016 IPR003673 CoA-transferase family III GO:0003824 SPH21_RS11550 b74be5a6191e11e9da199beb17b5fd46 386 Gene3D G3DSA:3.30.1540.10 231 303 6.5E-7 T 21-04-2016 SPH21_RS11550 b74be5a6191e11e9da199beb17b5fd46 386 SUPERFAMILY SSF89796 1 379 6.41E-100 T 21-04-2016 IPR023606 CoA-transferase family III domain SPH21_RS11550 b74be5a6191e11e9da199beb17b5fd46 386 Gene3D G3DSA:3.40.50.10540 304 379 1.4E-86 T 21-04-2016 IPR023606 CoA-transferase family III domain SPH21_RS11550 b74be5a6191e11e9da199beb17b5fd46 386 Gene3D G3DSA:3.40.50.10540 2 217 1.4E-86 T 21-04-2016 IPR023606 CoA-transferase family III domain SPH21_RS11550 b74be5a6191e11e9da199beb17b5fd46 386 PANTHER PTHR24023 39 381 2.9E-41 T 21-04-2016 SPH21_RS11550 b74be5a6191e11e9da199beb17b5fd46 386 PANTHER PTHR24023:SF593 39 381 2.9E-41 T 21-04-2016 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 SUPERFAMILY SSF52540 233 476 3.03E-74 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 Gene3D G3DSA:1.10.8.60 407 482 1.8E-24 T 21-04-2016 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 SUPERFAMILY SSF46689 447 538 1.22E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 Gene3D G3DSA:3.40.50.300 231 406 5.2E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 320 335 - T 21-04-2016 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 447 456 - T 21-04-2016 IPR025944 Sigma-54 interaction domain, conserved site SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 Gene3D G3DSA:1.10.10.60 495 539 9.7E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 Gene3D G3DSA:3.30.450.40 20 203 3.2E-13 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 Pfam PF00158 Sigma-54 interaction domain 234 400 3.3E-70 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 SMART SM00382 254 398 3.8E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 SUPERFAMILY SSF55781 28 212 2.23E-11 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 Pfam PF02954 Bacterial regulatory protein, Fis family 497 536 3.6E-5 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 258 271 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS24095 76a591a039275d974e3ef3648e7b0669 544 PANTHER PTHR32071 200 541 7.4E-155 T 21-04-2016 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 64 106 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SUPERFAMILY SSF46689 63 111 1.61E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SUPERFAMILY SSF48452 461 559 1.64E-18 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 Pfam PF13181 Tetratricopeptide repeat 387 418 1.2E-5 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 94 110 8.2E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 79 94 8.2E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 PANTHER PTHR11019 12 121 6.5E-25 T 21-04-2016 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 Gene3D G3DSA:1.10.10.60 64 113 2.4E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SMART SM00028 308 344 75.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SMART SM00028 530 563 16.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SMART SM00028 386 419 7.2E-5 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SMART SM00028 461 494 240.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 Gene3D G3DSA:1.10.10.60 7 63 5.3E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 Gene3D G3DSA:1.25.40.10 311 630 1.5E-24 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SUPERFAMILY SSF48452 522 639 4.48E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SUPERFAMILY SSF48452 311 419 1.64E-18 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 Pfam PF13176 Tetratricopeptide repeat 535 562 0.028 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 Pfam PF12833 Helix-turn-helix domain 33 108 4.6E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS05915 471cebd85e14c6fac0391930bd4a79dd 687 SMART SM00342 27 110 3.2E-28 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 Pfam PF00754 F5/8 type C domain 336 443 5.5E-17 T 21-04-2016 IPR000421 Coagulation factor 5/8 C-terminal domain SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 SUPERFAMILY SSF49899 520 687 5.59E-25 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 Gene3D G3DSA:2.60.120.200 523 687 4.5E-22 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 PANTHER PTHR22925 31 308 2.0E-48 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 Pfam PF04616 Glycosyl hydrolases family 43 31 307 2.4E-48 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 SMART SM00560 553 682 1.8E-4 T 21-04-2016 IPR006558 LamG-like jellyroll fold SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 SUPERFAMILY SSF49785 328 459 3.05E-23 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 SUPERFAMILY SSF75005 12 308 6.0E-60 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 546 684 2.2E-20 T 21-04-2016 SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 Gene3D G3DSA:2.60.120.260 330 456 1.3E-19 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS26090 b7aa004c091018ce79308d41246d00b2 1150 Gene3D G3DSA:2.115.10.20 28 317 1.4E-65 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS01840 922549365dc8202bfb1a8e3777c12a2b 662 PANTHER PTHR17630 67 237 1.6E-25 T 21-04-2016 SPH21_RS01840 922549365dc8202bfb1a8e3777c12a2b 662 Pfam PF05448 Acetyl xylan esterase (AXE1) 79 235 1.6E-16 T 21-04-2016 IPR008391 Acetyl xylan esterase SPH21_RS01840 922549365dc8202bfb1a8e3777c12a2b 662 SUPERFAMILY SSF53474 81 342 1.38E-30 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS01840 922549365dc8202bfb1a8e3777c12a2b 662 Gene3D G3DSA:3.40.50.1820 67 248 1.3E-41 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS01840 922549365dc8202bfb1a8e3777c12a2b 662 PANTHER PTHR17630:SF49 67 237 1.6E-25 T 21-04-2016 SPH21_RS11970 c2aa8a67bcfaac49a6a851ad526cf287 169 SUPERFAMILY SSF51316 48 168 8.89E-49 T 21-04-2016 IPR011057 Mss4-like SPH21_RS11970 c2aa8a67bcfaac49a6a851ad526cf287 169 Gene3D G3DSA:2.170.150.20 43 168 6.0E-50 T 21-04-2016 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 SPH21_RS11970 c2aa8a67bcfaac49a6a851ad526cf287 169 PANTHER PTHR10173:SF18 52 169 6.9E-46 T 21-04-2016 SPH21_RS11970 c2aa8a67bcfaac49a6a851ad526cf287 169 Pfam PF01641 SelR domain 52 166 2.6E-43 T 21-04-2016 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 SPH21_RS11970 c2aa8a67bcfaac49a6a851ad526cf287 169 PANTHER PTHR10173 52 169 6.9E-46 T 21-04-2016 IPR028427 Peptide methionine sulfoxide reductase GO:0006979|GO:0016671|GO:0030091 SPH21_RS11970 c2aa8a67bcfaac49a6a851ad526cf287 169 TIGRFAM TIGR00357 TIGR00357: methionine-R-sulfoxide reductase 52 168 1.3E-35 T 21-04-2016 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 Gene3D G3DSA:3.40.50.300 2 246 1.9E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 SMART SM00382 32 232 2.4E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 TIGRFAM TIGR00972 3a0107s01c2: phosphate ABC transporter, ATP-binding protein 9 253 8.6E-112 T 21-04-2016 IPR005670 Phosphate transport system permease protein 1 GO:0005315|GO:0016020|GO:0035435 SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 PANTHER PTHR24220 9 250 3.1E-115 T 21-04-2016 SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 ProSitePatterns PS00211 ABC transporters family signature. 150 164 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 Pfam PF00005 ABC transporter 23 177 6.1E-30 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 SUPERFAMILY SSF52540 8 247 9.11E-59 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23335 aa2bdc68773d72cc1926335786794d17 253 PANTHER PTHR24220:SF585 9 250 3.1E-115 T 21-04-2016 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 Gene3D G3DSA:3.40.720.10 28 448 2.0E-121 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 Pfam PF00884 Sulfatase 31 418 5.0E-70 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 PANTHER PTHR10342:SF199 373 542 4.8E-151 T 21-04-2016 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 PANTHER PTHR10342:SF199 3 253 4.8E-151 T 21-04-2016 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 PANTHER PTHR10342:SF199 280 346 4.8E-151 T 21-04-2016 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 Gene3D G3DSA:3.30.1120.10 453 524 4.5E-19 T 21-04-2016 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 SUPERFAMILY SSF53649 29 519 3.05E-143 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 PANTHER PTHR10342 373 542 4.8E-151 T 21-04-2016 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 PANTHER PTHR10342 3 253 4.8E-151 T 21-04-2016 SPH21_RS04690 413fa724b3fe4a59c29e057704afb819 542 PANTHER PTHR10342 280 346 4.8E-151 T 21-04-2016 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 108 121 2.4E-30 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 144 162 2.4E-30 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 229 246 2.4E-30 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 171 187 2.4E-30 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 265 280 2.4E-30 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 TIGRFAM TIGR01534 GAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I 3 324 1.9E-127 T 21-04-2016 IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I GO:0006006|GO:0016620|GO:0050661|GO:0051287|GO:0055114 KEGG: 00010+1.2.1.12|KEGG: 00710+1.2.1.12|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 SMART SM00846 2 150 3.0E-86 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PANTHER PTHR10836:SF57 1 329 3.9E-185 T 21-04-2016 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 SUPERFAMILY SSF55347 150 313 3.12E-57 T 21-04-2016 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 Gene3D G3DSA:3.40.50.720 1 158 2.7E-75 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 SUPERFAMILY SSF51735 2 166 8.46E-63 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 ProSitePatterns PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 148 155 - T 21-04-2016 IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2 150 6.6E-60 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PIRSF PIRSF000149 1 332 4.7E-117 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 Gene3D G3DSA:3.30.360.10 159 314 1.4E-58 T 21-04-2016 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 155 312 2.6E-52 T 21-04-2016 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS25060 df155b05b9f707bb31ae9d56a2332f44 332 PANTHER PTHR10836 1 329 3.9E-185 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 Gene3D G3DSA:1.10.10.60 224 270 5.2E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 238 253 6.0E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 253 269 6.0E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 Pfam PF12833 Helix-turn-helix domain 192 270 2.6E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 Gene3D G3DSA:2.60.120.280 28 157 3.7E-10 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 SMART SM00342 186 269 6.5E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 PANTHER PTHR11019:SF80 35 269 8.3E-32 T 21-04-2016 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 SUPERFAMILY SSF46689 224 270 2.37E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 PANTHER PTHR11019 35 269 8.3E-32 T 21-04-2016 SPH21_RS13280 a4f194badc66f41c50791d5b2e904860 272 SUPERFAMILY SSF51215 27 157 1.57E-9 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS09565 42bd5943beca7424c0e611f0c03576ec 276 Gene3D G3DSA:3.30.565.10 149 261 2.6E-8 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09565 42bd5943beca7424c0e611f0c03576ec 276 PANTHER PTHR24423 52 276 4.5E-18 T 21-04-2016 SPH21_RS09565 42bd5943beca7424c0e611f0c03576ec 276 PANTHER PTHR24423:SF468 52 276 4.5E-18 T 21-04-2016 SPH21_RS09565 42bd5943beca7424c0e611f0c03576ec 276 SMART SM00387 179 276 0.0074 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09565 42bd5943beca7424c0e611f0c03576ec 276 Pfam PF07568 Histidine kinase 84 159 5.5E-22 T 21-04-2016 IPR011495 Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain SPH21_RS09565 42bd5943beca7424c0e611f0c03576ec 276 SUPERFAMILY SSF55874 144 262 6.02E-10 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02150 39e0433d9344234008fb0e9c2b4ec5b6 199 SMART SM00855 3 158 1.7E-18 T 21-04-2016 IPR013078 Histidine phosphatase superfamily, clade-1 SPH21_RS02150 39e0433d9344234008fb0e9c2b4ec5b6 199 PANTHER PTHR23029 3 198 7.4E-44 T 21-04-2016 SPH21_RS02150 39e0433d9344234008fb0e9c2b4ec5b6 199 PIRSF PIRSF000709 2 180 8.3E-18 T 21-04-2016 SPH21_RS02150 39e0433d9344234008fb0e9c2b4ec5b6 199 Gene3D G3DSA:3.40.50.1240 1 197 3.0E-51 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS02150 39e0433d9344234008fb0e9c2b4ec5b6 199 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 4 190 5.6E-54 T 21-04-2016 IPR013078 Histidine phosphatase superfamily, clade-1 SPH21_RS02150 39e0433d9344234008fb0e9c2b4ec5b6 199 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 6 15 - T 21-04-2016 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 UniPathway: UPA00109 SPH21_RS02150 39e0433d9344234008fb0e9c2b4ec5b6 199 SUPERFAMILY SSF53254 1 195 4.71E-52 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS19320 c4b6950b81518894d32780995aae21fa 239 PANTHER PTHR12598 1 239 1.9E-102 T 21-04-2016 IPR005627 Copper homeostasis protein CutC GO:0005507|GO:0055070 SPH21_RS19320 c4b6950b81518894d32780995aae21fa 239 Gene3D G3DSA:3.20.20.380 1 238 4.5E-92 T 21-04-2016 IPR023648 Copper homeostasis CutC domain GO:0005507|GO:0055070 SPH21_RS19320 c4b6950b81518894d32780995aae21fa 239 SUPERFAMILY SSF110395 1 237 1.44E-70 T 21-04-2016 IPR023648 Copper homeostasis CutC domain GO:0005507|GO:0055070 SPH21_RS19320 c4b6950b81518894d32780995aae21fa 239 Pfam PF03932 CutC family 1 201 5.2E-80 T 21-04-2016 IPR005627 Copper homeostasis protein CutC GO:0005507|GO:0055070 SPH21_RS19320 c4b6950b81518894d32780995aae21fa 239 Hamap MF_00795 Copper homeostasis protein CutC [cutC]. 1 238 37.209 T 21-04-2016 IPR005627 Copper homeostasis protein CutC GO:0005507|GO:0055070 SPH21_RS19320 c4b6950b81518894d32780995aae21fa 239 PANTHER PTHR12598:SF0 1 239 1.9E-102 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 SUPERFAMILY SSF56935 565 938 5.49E-82 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 SUPERFAMILY SSF56935 216 360 5.49E-82 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 SUPERFAMILY SSF56935 443 533 5.49E-82 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 SUPERFAMILY SSF56935 1009 1053 5.49E-82 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 SUPERFAMILY SSF56935 1089 1170 5.49E-82 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 Pfam PF13715 CarboxypepD_reg-like domain 139 219 4.6E-14 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 Pfam PF07715 TonB-dependent Receptor Plug Domain 230 336 7.9E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 138 1173 5.2E-268 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 Gene3D G3DSA:2.40.170.20 450 947 1.7E-24 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 313 342 3.5E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 SUPERFAMILY SSF49464 137 217 5.62E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 Gene3D G3DSA:2.60.40.1120 138 228 3.7E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532 136 382 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532 432 558 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532 658 688 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532 718 1171 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532:SF57 136 382 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532:SF57 432 558 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532:SF57 658 688 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 PANTHER PTHR11532:SF57 718 1171 1.0E-261 T 21-04-2016 SPH21_RS20965 ecb3d8b94a46bae17f2f4bdc0f8406e8 1173 Gene3D G3DSA:2.170.130.10 230 345 3.6E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 SUPERFAMILY SSF82689 704 791 1.44E-7 T 21-04-2016 IPR011066 Mechanosensitive ion channel MscS, C-terminal GO:0016020 SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 PANTHER PTHR30347:SF3 554 791 6.7E-45 T 21-04-2016 SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 Gene3D G3DSA:3.30.70.100 706 790 3.6E-4 T 21-04-2016 SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 PANTHER PTHR30347 554 791 6.7E-45 T 21-04-2016 SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 SUPERFAMILY SSF82861 554 635 6.28E-6 T 21-04-2016 IPR011014 Mechanosensitive ion channel MscS, transmembrane-2 GO:0016020 SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 Pfam PF00924 Mechanosensitive ion channel 595 790 6.0E-40 T 21-04-2016 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 SUPERFAMILY SSF50182 637 702 1.34E-16 T 21-04-2016 IPR010920 LSM domain SPH21_RS14110 f4d189d42b47e831d171ddf87f6ed959 793 Gene3D G3DSA:2.30.30.60 653 701 9.2E-17 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 Pfam PF07715 TonB-dependent Receptor Plug Domain 114 221 1.0E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 23 1042 1.6E-233 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 Gene3D G3DSA:2.170.130.10 105 225 2.7E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 SUPERFAMILY SSF49464 23 103 1.7E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 Pfam PF13715 CarboxypepD_reg-like domain 25 105 7.1E-14 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 Gene3D G3DSA:2.60.40.1120 25 104 1.1E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 SUPERFAMILY SSF56935 948 1008 2.84E-84 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 SUPERFAMILY SSF56935 866 910 2.84E-84 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 SUPERFAMILY SSF56935 101 245 2.84E-84 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 SUPERFAMILY SSF56935 469 806 2.84E-84 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 SUPERFAMILY SSF56935 330 421 2.84E-84 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532 594 1040 6.1E-213 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532 1 298 6.1E-213 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532 326 442 6.1E-213 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532 540 576 6.1E-213 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 Gene3D G3DSA:2.40.170.20 337 806 4.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 197 227 1.4E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532:SF57 594 1040 6.1E-213 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532:SF57 1 298 6.1E-213 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532:SF57 326 442 6.1E-213 T 21-04-2016 SPH21_RS04930 92681c33e770fa1b53096678d35f6f29 1042 PANTHER PTHR11532:SF57 540 576 6.1E-213 T 21-04-2016 SPH21_RS19340 584c6f1fc890f2536c7ec775afc8b2b5 231 SUPERFAMILY SSF46785 153 225 4.9E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19340 584c6f1fc890f2536c7ec775afc8b2b5 231 Gene3D G3DSA:1.10.10.10 146 226 8.3E-34 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19340 584c6f1fc890f2536c7ec775afc8b2b5 231 SUPERFAMILY SSF55811 13 149 3.38E-30 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS19340 584c6f1fc890f2536c7ec775afc8b2b5 231 Pfam PF00293 NUDIX domain 15 139 1.9E-12 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS19340 584c6f1fc890f2536c7ec775afc8b2b5 231 Gene3D G3DSA:3.90.79.10 12 141 1.2E-40 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS19340 584c6f1fc890f2536c7ec775afc8b2b5 231 PANTHER PTHR22769 27 190 8.7E-35 T 21-04-2016 SPH21_RS19340 584c6f1fc890f2536c7ec775afc8b2b5 231 PANTHER PTHR22769:SF42 27 190 8.7E-35 T 21-04-2016 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 SUPERFAMILY SSF52440 555 672 4.32E-46 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 836 843 - T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Gene3D G3DSA:3.30.1490.20 142 198 6.9E-23 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Gene3D G3DSA:3.30.1490.20 684 742 9.4E-26 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Gene3D G3DSA:3.40.50.20 537 660 1.0E-57 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PANTHER PTHR11405:SF5 1 924 0.0 T 21-04-2016 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 SUPERFAMILY SSF56059 671 924 3.89E-90 T 21-04-2016 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 TIGRFAM TIGR01369 CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit 2 932 0.0 T 21-04-2016 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 168 180 3.1E-64 T 21-04-2016 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 19 33 3.1E-64 T 21-04-2016 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 204 223 3.1E-64 T 21-04-2016 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 379 397 3.1E-64 T 21-04-2016 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 297 326 3.1E-64 T 21-04-2016 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 239 256 3.1E-64 T 21-04-2016 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 48 58 3.1E-64 T 21-04-2016 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 SUPERFAMILY SSF52440 1 127 1.06E-42 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Gene3D G3DSA:1.10.1030.10 399 536 2.7E-47 T 21-04-2016 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 SMART SM01096 421 545 6.2E-62 T 21-04-2016 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Pfam PF02787 Carbamoyl-phosphate synthetase large chain, oligomerisation domain 424 545 1.7E-39 T 21-04-2016 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 SUPERFAMILY SSF56059 128 400 2.47E-102 T 21-04-2016 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 SUPERFAMILY SSF48108 395 552 9.81E-49 T 21-04-2016 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Gene3D G3DSA:3.40.50.20 4 107 7.0E-38 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Gene3D G3DSA:3.30.470.20 743 921 1.1E-60 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Gene3D G3DSA:3.30.470.20 199 398 6.2E-74 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 PANTHER PTHR11405 1 924 0.0 T 21-04-2016 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 SMART SM01209 677 839 2.0E-4 T 21-04-2016 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 164 178 - T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 707 721 - T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 129 334 8.9E-67 T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS05515 3df1f63a300f515596cb3e388813c0b6 938 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 671 869 4.4E-33 T 21-04-2016 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 5 327 3.8E-109 T 21-04-2016 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 4 327 67.203 T 21-04-2016 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 Gene3D G3DSA:3.40.47.10 3 163 2.0E-59 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 Gene3D G3DSA:3.40.47.10 164 327 8.2E-49 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 SUPERFAMILY SSF53901 8 327 9.02E-65 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 PANTHER PTHR34069:SF2 2 329 1.9E-131 T 21-04-2016 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 110 188 4.1E-29 T 21-04-2016 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 PANTHER PTHR34069 2 329 1.9E-131 T 21-04-2016 SPH21_RS00055 4c4fb35d11dd0e126ea51301a9a8d220 329 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 240 327 5.3E-32 T 21-04-2016 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS10660 85736f6bfba2590be825e94110ac8765 297 Pfam PF04616 Glycosyl hydrolases family 43 6 282 7.8E-39 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS10660 85736f6bfba2590be825e94110ac8765 297 Gene3D G3DSA:2.115.10.20 4 282 3.7E-63 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS10660 85736f6bfba2590be825e94110ac8765 297 SUPERFAMILY SSF75005 3 282 4.85E-57 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS10660 85736f6bfba2590be825e94110ac8765 297 PANTHER PTHR22925:SF37 6 292 7.0E-66 T 21-04-2016 SPH21_RS10660 85736f6bfba2590be825e94110ac8765 297 PANTHER PTHR22925 6 292 7.0E-66 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS14100 6e974523a074ddddebbc94ff0172ce9d 489 Gene3D G3DSA:1.25.40.10 334 431 1.2E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14100 6e974523a074ddddebbc94ff0172ce9d 489 Gene3D G3DSA:1.25.40.10 197 302 1.2E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14100 6e974523a074ddddebbc94ff0172ce9d 489 SUPERFAMILY SSF48452 18 489 2.78E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14100 6e974523a074ddddebbc94ff0172ce9d 489 Pfam PF14322 Starch-binding associating with outer membrane 96 213 1.8E-28 T 21-04-2016 SPH21_RS14100 6e974523a074ddddebbc94ff0172ce9d 489 Pfam PF07980 SusD family 337 489 4.2E-31 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 Pfam PF01225 Mur ligase family, catalytic domain 3 102 5.1E-9 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 Gene3D G3DSA:3.40.50.720 1 91 1.5E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 Pfam PF02875 Mur ligase family, glutamate ligase domain 306 384 1.2E-7 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 PANTHER PTHR23135 1 437 9.3E-68 T 21-04-2016 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 SUPERFAMILY SSF53244 303 442 2.2E-27 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 PANTHER PTHR23135:SF5 1 437 9.3E-68 T 21-04-2016 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 SUPERFAMILY SSF53623 93 302 1.31E-34 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 Gene3D G3DSA:3.90.190.20 306 441 1.6E-26 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 SUPERFAMILY SSF51984 1 91 2.62E-15 T 21-04-2016 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 Pfam PF08245 Mur ligase middle domain 108 283 2.6E-20 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS15165 05b1508f806c686ad03d5566c302994c 453 Gene3D G3DSA:3.40.1190.10 96 305 1.6E-48 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Gene3D G3DSA:3.40.50.300 543 742 6.6E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Hamap MF_00969 Transcription-repair-coupling factor [mfd]. 42 1077 27.581 T 21-04-2016 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Pfam PF02559 CarD-like/TRCF domain 436 531 5.8E-25 T 21-04-2016 IPR003711 CarD-like/TRCF domain SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SUPERFAMILY SSF52540 738 946 8.8E-45 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SUPERFAMILY SSF52540 485 740 5.48E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Pfam PF03461 TRCF domain 971 1060 3.1E-22 T 21-04-2016 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SMART SM00982 969 1068 1.1E-21 T 21-04-2016 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SUPERFAMILY SSF52540 19 281 3.01E-61 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Gene3D G3DSA:3.40.50.300 757 912 6.3E-34 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SMART SM00487 556 752 4.5E-31 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SMART SM00490 782 866 3.6E-18 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 TIGRFAM TIGR00580 mfd: transcription-repair coupling factor 239 1042 7.3E-282 T 21-04-2016 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Pfam PF00270 DEAD/DEAH box helicase 562 718 7.4E-16 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Gene3D G3DSA:3.30.2060.10 143 221 1.3E-11 T 21-04-2016 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SUPERFAMILY SSF141259 427 504 1.57E-21 T 21-04-2016 IPR003711 CarD-like/TRCF domain SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 PANTHER PTHR14025 341 1110 0.0 T 21-04-2016 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SMART SM01058 435 532 3.6E-39 T 21-04-2016 IPR003711 CarD-like/TRCF domain SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 SUPERFAMILY SSF143517 961 1103 4.58E-28 T 21-04-2016 SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 Pfam PF00271 Helicase conserved C-terminal domain 763 865 1.8E-16 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS06610 cc0586256ef425cd167881096c1d04f9 1112 PANTHER PTHR14025:SF21 341 1110 0.0 T 21-04-2016 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Pfam PF00128 Alpha amylase, catalytic domain 28 110 3.8E-14 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:3.20.20.80 910 1408 5.1E-166 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:1.10.10.470 606 697 1.3E-22 T 21-04-2016 IPR013797 Maltooligosyl trehalose synthase, N-terminal MetaCyc: PWY-2661 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 SMART SM00642 9 526 9.7E-4 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 TIGRFAM TIGR02401 trehalose_TreY: malto-oligosyltrehalose synthase 7 903 1.7E-245 T 21-04-2016 IPR012767 Malto-oligosyltrehalose synthase MetaCyc: PWY-2661 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:3.20.20.80 7 105 1.1E-63 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:3.20.20.80 565 605 1.1E-63 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:3.20.20.80 305 378 1.1E-63 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:3.20.20.80 710 833 1.1E-63 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 TIGRFAM TIGR00217 malQ: 4-alpha-glucanotransferase 909 1398 1.5E-92 T 21-04-2016 IPR003385 Glycoside hydrolase, family 77 GO:0004134|GO:0005975 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:3.30.1590.10 106 178 1.5E-33 T 21-04-2016 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Gene3D G3DSA:3.30.1590.10 251 288 1.5E-33 T 21-04-2016 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 PANTHER PTHR32438:SF5 906 1408 1.3E-140 T 21-04-2016 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 SUPERFAMILY SSF51445 8 140 1.46E-102 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 SUPERFAMILY SSF51445 515 804 1.46E-102 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 SUPERFAMILY SSF51445 247 488 1.46E-102 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 PANTHER PTHR32438 906 1408 1.3E-140 T 21-04-2016 SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 SUPERFAMILY SSF51445 912 1407 4.99E-157 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01530 382a5f3404ff7c8583b29ce149f8ab47 1408 Pfam PF02446 4-alpha-glucanotransferase 919 1386 5.3E-152 T 21-04-2016 IPR003385 Glycoside hydrolase, family 77 GO:0004134|GO:0005975 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SPH21_RS08455 510ed09b0371dc0983eb05cfd4b1728e 308 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 60 169 4.8E-22 T 21-04-2016 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SPH21_RS08455 510ed09b0371dc0983eb05cfd4b1728e 308 PANTHER PTHR23344 55 288 1.9E-33 T 21-04-2016 IPR004129 Glycerophosphoryl diester phosphodiesterase GO:0008889 SPH21_RS08455 510ed09b0371dc0983eb05cfd4b1728e 308 Gene3D G3DSA:3.20.20.190 48 297 3.7E-47 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS08455 510ed09b0371dc0983eb05cfd4b1728e 308 PANTHER PTHR23344:SF20 55 288 1.9E-33 T 21-04-2016 SPH21_RS08455 510ed09b0371dc0983eb05cfd4b1728e 308 SUPERFAMILY SSF51695 55 288 2.09E-46 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS25655 27d1d8f7bf872c17aea9d6a6b6240e1e 200 Hamap MF_00321 Probable GTP-binding protein EngB [engB]. 11 195 25.361 T 21-04-2016 IPR019987 GTP-binding protein, ribosome biogenesis, YsxC GO:0000917|GO:0005525 SPH21_RS25655 27d1d8f7bf872c17aea9d6a6b6240e1e 200 SUPERFAMILY SSF52540 19 193 2.84E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25655 27d1d8f7bf872c17aea9d6a6b6240e1e 200 PANTHER PTHR11649 3 188 2.7E-59 T 21-04-2016 SPH21_RS25655 27d1d8f7bf872c17aea9d6a6b6240e1e 200 Pfam PF01926 50S ribosome-binding GTPase 26 143 3.8E-22 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS25655 27d1d8f7bf872c17aea9d6a6b6240e1e 200 TIGRFAM TIGR03598 GTPase_YsxC: ribosome biogenesis GTP-binding protein YsxC 6 190 2.7E-65 T 21-04-2016 IPR019987 GTP-binding protein, ribosome biogenesis, YsxC GO:0000917|GO:0005525 SPH21_RS25655 27d1d8f7bf872c17aea9d6a6b6240e1e 200 Gene3D G3DSA:3.40.50.300 5 194 1.7E-42 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25655 27d1d8f7bf872c17aea9d6a6b6240e1e 200 PANTHER PTHR11649:SF49 3 188 2.7E-59 T 21-04-2016 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 Gene3D G3DSA:1.25.40.10 258 339 9.4E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 Gene3D G3DSA:1.25.40.10 397 567 2.9E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 Gene3D G3DSA:1.25.40.10 31 248 1.2E-28 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 Pfam PF13181 Tetratricopeptide repeat 527 559 0.043 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SUPERFAMILY SSF48452 400 562 5.55E-8 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SUPERFAMILY SSF81901 30 239 6.02E-23 T 21-04-2016 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 PANTHER PTHR23083 30 359 3.6E-31 T 21-04-2016 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 PANTHER PTHR23083 476 582 3.6E-31 T 21-04-2016 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 PANTHER PTHR23083 406 425 3.6E-31 T 21-04-2016 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SMART SM00028 164 197 51.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SMART SM00028 527 560 0.012 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SMART SM00028 198 231 260.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SMART SM00028 57 90 19.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SMART SM00028 311 344 390.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 SUPERFAMILY SSF48452 257 346 1.18E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07850 b2e679bb320b6c18bf23246f2d96f140 583 Pfam PF14559 Tetratricopeptide repeat 33 90 1.7E-6 T 21-04-2016 SPH21_RS19555 2e099e84ef8a313679938a77573fa38f 338 Gene3D G3DSA:3.60.10.10 74 331 1.2E-9 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS19555 2e099e84ef8a313679938a77573fa38f 338 PANTHER PTHR33354 71 331 2.8E-49 T 21-04-2016 SPH21_RS19555 2e099e84ef8a313679938a77573fa38f 338 PANTHER PTHR33354:SF2 71 331 2.8E-49 T 21-04-2016 SPH21_RS19555 2e099e84ef8a313679938a77573fa38f 338 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 77 301 1.1E-12 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS19555 2e099e84ef8a313679938a77573fa38f 338 SUPERFAMILY SSF56219 71 331 7.33E-46 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 Gene3D G3DSA:3.30.565.10 412 536 1.3E-12 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 PANTHER PTHR24421 334 536 1.2E-12 T 21-04-2016 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 PRINTS PR00344 Bacterial sensor protein C-terminal signature 483 497 8.2E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 PRINTS PR00344 Bacterial sensor protein C-terminal signature 522 535 8.2E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 PRINTS PR00344 Bacterial sensor protein C-terminal signature 498 516 8.2E-6 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 SUPERFAMILY SSF55874 440 536 2.36E-15 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 PANTHER PTHR24421:SF1 334 536 1.2E-12 T 21-04-2016 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 452 536 4.8E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 SUPERFAMILY SSF48452 126 260 3.13E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 SMART SM00028 44 77 92.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 SMART SM00028 86 119 140.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 SMART SM00028 123 156 1.8 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 SUPERFAMILY SSF48452 22 153 4.74E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 Gene3D G3DSA:1.25.40.10 138 293 6.8E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24415 7b06f39e9987fec581411f1cc21889f5 537 Gene3D G3DSA:1.25.40.10 41 137 1.1E-8 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05025 b1442a792bb419a27cd624d5a4ec69bc 382 PANTHER PTHR10091 24 382 1.7E-162 T 21-04-2016 SPH21_RS05025 b1442a792bb419a27cd624d5a4ec69bc 382 SUPERFAMILY SSF74650 41 380 1.26E-121 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS05025 b1442a792bb419a27cd624d5a4ec69bc 382 ProSitePatterns PS00545 Aldose 1-epimerase putative active site. 206 215 - T 21-04-2016 IPR018052 Aldose 1-epimerase, conserved site KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317|UniPathway: UPA00242 SPH21_RS05025 b1442a792bb419a27cd624d5a4ec69bc 382 Pfam PF01263 Aldose 1-epimerase 51 378 4.5E-100 T 21-04-2016 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 SPH21_RS05025 b1442a792bb419a27cd624d5a4ec69bc 382 Gene3D G3DSA:2.70.98.10 41 381 7.6E-138 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS05025 b1442a792bb419a27cd624d5a4ec69bc 382 PIRSF PIRSF005096 32 382 4.1E-135 T 21-04-2016 IPR015443 Aldose 1-epimerase GO:0016853|GO:0019318 KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317|UniPathway: UPA00242 SPH21_RS00910 a049a860dedd548c1b13e65cf973ed0d 193 SMART SM00100 5 130 1.5E-8 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS00910 a049a860dedd548c1b13e65cf973ed0d 193 Gene3D G3DSA:1.10.10.10 142 192 4.2E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00910 a049a860dedd548c1b13e65cf973ed0d 193 Gene3D G3DSA:2.60.120.10 2 141 3.1E-42 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS00910 a049a860dedd548c1b13e65cf973ed0d 193 PANTHER PTHR24567 20 190 1.1E-30 T 21-04-2016 SPH21_RS00910 a049a860dedd548c1b13e65cf973ed0d 193 Pfam PF00027 Cyclic nucleotide-binding domain 30 116 7.3E-15 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS00910 a049a860dedd548c1b13e65cf973ed0d 193 PANTHER PTHR24567:SF33 20 190 1.1E-30 T 21-04-2016 SPH21_RS00910 a049a860dedd548c1b13e65cf973ed0d 193 SUPERFAMILY SSF51206 17 143 1.7E-28 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 PIRSF PIRSF000727 1 814 7.5E-279 T 21-04-2016 IPR011147 Bifunctional aspartokinase/homoserine dehydrogenase I GO:0004072|GO:0004412|GO:0009067|GO:0055114 KEGG: 00260+1.1.1.3+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+1.1.1.3+2.7.2.4|KEGG: 00300+1.1.1.3+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00050|UniPathway: UPA00051|UniPathway: UPA00051 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Pfam PF00696 Amino acid kinase family 2 283 3.4E-42 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 PANTHER PTHR21499:SF3 3 470 9.3E-135 T 21-04-2016 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 SUPERFAMILY SSF51735 463 637 2.36E-31 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 ProSitePatterns PS01042 Homoserine dehydrogenase signature. 661 683 - T 21-04-2016 IPR019811 Homoserine dehydrogenase, conserved site GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 ProSitePatterns PS00324 Aspartokinase signature. 3 11 - T 21-04-2016 IPR018042 Aspartate kinase, conserved site GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Gene3D G3DSA:3.30.360.10 637 793 7.6E-52 T 21-04-2016 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Pfam PF13840 ACT domain 391 456 7.1E-8 T 21-04-2016 IPR027795 GATS-like ACT domain SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Pfam PF00742 Homoserine dehydrogenase 615 811 1.5E-50 T 21-04-2016 IPR001342 Homoserine dehydrogenase, catalytic GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 SUPERFAMILY SSF55347 615 798 9.81E-47 T 21-04-2016 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 TIGRFAM TIGR00657 asp_kinases: aspartate kinase 3 459 1.9E-118 T 21-04-2016 IPR001341 Aspartate kinase domain GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Gene3D G3DSA:3.40.50.720 464 636 1.6E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Pfam PF03447 Homoserine dehydrogenase, NAD binding domain 472 607 3.2E-20 T 21-04-2016 IPR005106 Aspartate/homoserine dehydrogenase, NAD-binding GO:0016491|GO:0050661|GO:0055114 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 PANTHER PTHR21499 3 470 9.3E-135 T 21-04-2016 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 SUPERFAMILY SSF55021 390 461 6.3E-22 T 21-04-2016 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Pfam PF01842 ACT domain 326 379 5.1E-7 T 21-04-2016 IPR002912 ACT domain GO:0008152|GO:0016597 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 SUPERFAMILY SSF53633 1 295 8.87E-72 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 SUPERFAMILY SSF55021 303 380 1.63E-19 T 21-04-2016 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Gene3D G3DSA:3.40.1160.10 109 297 3.7E-55 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS07040 c186644faf270b79d10d2440e55958da 815 Gene3D G3DSA:3.40.1160.10 1 50 3.7E-55 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 SUPERFAMILY SSF49464 52 139 3.27E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Pfam PF00593 TonB dependent receptor 641 1057 1.4E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 51 1058 3.2E-240 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Gene3D G3DSA:2.40.170.20 247 267 4.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Gene3D G3DSA:2.40.170.20 894 919 4.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Gene3D G3DSA:2.40.170.20 355 840 4.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Gene3D G3DSA:2.40.170.20 963 1058 4.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 PANTHER PTHR11532 31 414 6.9E-231 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 PANTHER PTHR11532 476 1056 6.9E-231 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Gene3D G3DSA:2.60.40.1120 52 135 4.0E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 PANTHER PTHR11532:SF57 31 414 6.9E-231 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 PANTHER PTHR11532:SF57 476 1056 6.9E-231 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Pfam PF07715 TonB-dependent Receptor Plug Domain 142 247 1.7E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 SUPERFAMILY SSF56935 464 815 1.51E-84 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 SUPERFAMILY SSF56935 971 1058 1.51E-84 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 SUPERFAMILY SSF56935 129 271 1.51E-84 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 SUPERFAMILY SSF56935 346 435 1.51E-84 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 SUPERFAMILY SSF56935 886 929 1.51E-84 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Pfam PF13715 CarboxypepD_reg-like domain 53 133 9.9E-13 T 21-04-2016 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 223 253 4.8E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS03070 7e5c31e31643ecf48049331c8e1211e6 1058 Gene3D G3DSA:2.170.130.10 136 246 7.9E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Gene3D G3DSA:3.30.470.30 232 347 1.2E-25 T 21-04-2016 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Gene3D G3DSA:1.10.3260.10 4 172 1.1E-5 T 21-04-2016 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 Reactome: REACT_216 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Pfam PF01068 ATP dependent DNA ligase domain 218 402 2.7E-31 T 21-04-2016 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 Reactome: REACT_216 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 TIGRFAM TIGR04120 DNA_lig_bact: DNA ligase, ATP-dependent, PP_1105 family 2 527 1.4E-180 T 21-04-2016 IPR026333 ATP-dependent DNA ligase, PP_1105 family SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Gene3D G3DSA:3.30.1490.70 200 231 6.3E-19 T 21-04-2016 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Gene3D G3DSA:3.30.1490.70 359 402 6.3E-19 T 21-04-2016 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 PANTHER PTHR10459:SF10 2 531 1.3E-74 T 21-04-2016 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Pfam PF04679 ATP dependent DNA ligase C terminal region 423 512 3.6E-12 T 21-04-2016 IPR012309 DNA ligase, ATP-dependent, C-terminal GO:0003910|GO:0006281|GO:0006310 Reactome: REACT_216 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 SUPERFAMILY SSF50249 407 530 1.56E-32 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Pfam PF04675 DNA ligase N terminus 3 159 3.8E-22 T 21-04-2016 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 Reactome: REACT_216 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 PANTHER PTHR10459 2 531 1.3E-74 T 21-04-2016 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 SUPERFAMILY SSF56091 202 402 3.6E-53 T 21-04-2016 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 SUPERFAMILY SSF117018 4 177 2.09E-11 T 21-04-2016 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 Reactome: REACT_216 SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 Gene3D G3DSA:2.40.50.140 407 530 2.3E-37 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05450 91c0988f98813f64562fdb2ce724be69 532 ProSitePatterns PS00697 ATP-dependent DNA ligase AMP-binding site. 227 235 - T 21-04-2016 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 Reactome: REACT_216 SPH21_RS10490 a199e7e612fbf3d6adbf1462ded050bb 60 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 2 40 5.9E-8 T 21-04-2016 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SPH21_RS10490 a199e7e612fbf3d6adbf1462ded050bb 60 SUPERFAMILY SSF51735 1 43 2.13E-8 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10490 a199e7e612fbf3d6adbf1462ded050bb 60 Gene3D G3DSA:3.40.50.720 1 42 1.8E-10 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS13455 8133423f46e8b3b24d896a565b347498 273 TIGRFAM TIGR03707 PPK2_P_aer: polyphosphate kinase 2 36 254 2.9E-98 T 21-04-2016 IPR022486 Polyphosphate kinase 2, PA0141 GO:0006793|GO:0008976 SPH21_RS13455 8133423f46e8b3b24d896a565b347498 273 PANTHER PTHR34383:SF2 22 250 1.1E-100 T 21-04-2016 SPH21_RS13455 8133423f46e8b3b24d896a565b347498 273 PIRSF PIRSF028756 7 272 1.1E-96 T 21-04-2016 IPR016898 Polyphosphate kinase 2 SPH21_RS13455 8133423f46e8b3b24d896a565b347498 273 Pfam PF03976 Polyphosphate kinase 2 (PPK2) 37 255 1.3E-89 T 21-04-2016 IPR022488 Polyphosphate kinase-2-related SPH21_RS13455 8133423f46e8b3b24d896a565b347498 273 Gene3D G3DSA:3.40.50.300 35 261 6.9E-90 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13455 8133423f46e8b3b24d896a565b347498 273 SUPERFAMILY SSF52540 65 250 9.59E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13455 8133423f46e8b3b24d896a565b347498 273 PANTHER PTHR34383 22 250 1.1E-100 T 21-04-2016 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 SUPERFAMILY SSF51445 303 553 3.5E-47 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Gene3D G3DSA:2.60.40.320 188 295 9.2E-23 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 301 521 8.6E-35 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Gene3D G3DSA:2.70.98.10 755 859 1.3E-5 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Gene3D G3DSA:2.60.40.320 557 638 2.7E-5 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 SUPERFAMILY SSF74650 730 891 7.85E-15 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Gene3D G3DSA:3.20.20.80 296 556 1.6E-50 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Pfam PF02929 Beta galactosidase small chain 750 853 1.1E-5 T 21-04-2016 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 PRINTS PR00132 Glycosyl hydrolase family 2 signature 340 358 6.8E-9 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 PRINTS PR00132 Glycosyl hydrolase family 2 signature 309 323 6.8E-9 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 SUPERFAMILY SSF49785 7 197 5.1E-37 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 ProSitePatterns PS00719 Glycosyl hydrolases family 2 signature 1. 350 375 - T 21-04-2016 IPR023230 Glycoside hydrolase, family 2, conserved site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 SUPERFAMILY SSF49303 208 297 2.59E-15 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 PANTHER PTHR10066 54 871 1.6E-134 T 21-04-2016 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Gene3D G3DSA:2.60.120.260 18 187 2.0E-37 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 59 193 9.1E-20 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 SUPERFAMILY SSF49303 552 635 3.88E-5 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 Pfam PF00703 Glycosyl hydrolases family 2 209 297 1.3E-11 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS02380 e240bf570c96c6d9c03af0a991bc39e6 956 PANTHER PTHR10066:SF72 54 871 1.6E-134 T 21-04-2016 SPH21_RS11830 c4379181415a974f43975a6dd39f4dc3 234 SUPERFAMILY SSF47413 9 68 4.07E-6 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS11830 c4379181415a974f43975a6dd39f4dc3 234 Gene3D G3DSA:2.10.109.10 136 213 2.2E-7 T 21-04-2016 IPR028360 Peptidase S24/S26, beta-ribbon domain SPH21_RS11830 c4379181415a974f43975a6dd39f4dc3 234 SMART SM00530 13 68 0.0013 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS11830 c4379181415a974f43975a6dd39f4dc3 234 Gene3D G3DSA:1.10.260.40 10 71 1.9E-4 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS11830 c4379181415a974f43975a6dd39f4dc3 234 SUPERFAMILY SSF51306 132 211 9.42E-8 T 21-04-2016 IPR015927 Peptidase S24/S26A/S26B/S26C SPH21_RS16690 ab8e2e3c1931ce7651b03a5eb8d95ca7 410 Pfam PF07690 Major Facilitator Superfamily 59 348 1.4E-22 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS16690 ab8e2e3c1931ce7651b03a5eb8d95ca7 410 Gene3D G3DSA:1.20.1250.20 17 190 3.6E-20 T 21-04-2016 SPH21_RS16690 ab8e2e3c1931ce7651b03a5eb8d95ca7 410 PANTHER PTHR23508 14 409 1.4E-27 T 21-04-2016 SPH21_RS16690 ab8e2e3c1931ce7651b03a5eb8d95ca7 410 SUPERFAMILY SSF103473 9 406 1.01E-46 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 PIRSF PIRSF000390 16 378 3.5E-87 T 21-04-2016 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 Gene3D G3DSA:3.40.640.10 20 277 5.7E-84 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 Gene3D G3DSA:3.90.1150.10 278 378 4.9E-22 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 31 378 1.3E-81 T 21-04-2016 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 TIGRFAM TIGR04181 NHT_00031: aminotransferase, LLPSF_NHT_00031 family 21 378 3.8E-163 T 21-04-2016 IPR026385 Aminotransferase, LLPSF_NHT_00031 family SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 SUPERFAMILY SSF53383 18 378 6.54E-89 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 PANTHER PTHR30244:SF16 12 379 5.3E-124 T 21-04-2016 SPH21_RS08970 54998d0ba030d721191460c7d4fae34f 380 PANTHER PTHR30244 12 379 5.3E-124 T 21-04-2016 SPH21_RS04310 2baf8a53232189c1839382dd334e3426 322 PANTHER PTHR10655:SF33 50 230 8.4E-40 T 21-04-2016 SPH21_RS04310 2baf8a53232189c1839382dd334e3426 322 PANTHER PTHR10655 50 230 8.4E-40 T 21-04-2016 SPH21_RS04310 2baf8a53232189c1839382dd334e3426 322 Pfam PF10503 Esterase PHB depolymerase 60 193 7.8E-14 T 21-04-2016 IPR010126 Esterase, PHB depolymerase GO:0005576 SPH21_RS04310 2baf8a53232189c1839382dd334e3426 322 SUPERFAMILY SSF53474 263 293 6.78E-31 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04310 2baf8a53232189c1839382dd334e3426 322 SUPERFAMILY SSF53474 49 226 6.78E-31 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04310 2baf8a53232189c1839382dd334e3426 322 Gene3D G3DSA:3.40.50.1820 13 319 8.0E-39 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24760 533ea96b1395b47004707892baf95d60 167 Gene3D G3DSA:3.30.530.20 7 163 6.5E-36 T 21-04-2016 IPR023393 START-like domain SPH21_RS24760 533ea96b1395b47004707892baf95d60 167 PANTHER PTHR36929:SF1 14 162 5.6E-23 T 21-04-2016 SPH21_RS24760 533ea96b1395b47004707892baf95d60 167 SUPERFAMILY SSF55961 13 162 6.37E-34 T 21-04-2016 SPH21_RS24760 533ea96b1395b47004707892baf95d60 167 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 28 162 4.3E-17 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS24760 533ea96b1395b47004707892baf95d60 167 PANTHER PTHR36929 14 162 5.6E-23 T 21-04-2016 SPH21_RS21285 44e6a991d08d8382f18f38398ecb13c7 210 SUPERFAMILY SSF52833 34 193 1.35E-34 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS21285 44e6a991d08d8382f18f38398ecb13c7 210 Pfam PF02630 SCO1/SenC 4 172 2.9E-17 T 21-04-2016 IPR003782 Copper chaperone SCO1/SenC SPH21_RS21285 44e6a991d08d8382f18f38398ecb13c7 210 Gene3D G3DSA:3.40.30.10 11 193 2.8E-38 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS21285 44e6a991d08d8382f18f38398ecb13c7 210 PANTHER PTHR12151 36 188 6.5E-21 T 21-04-2016 IPR003782 Copper chaperone SCO1/SenC SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 Gene3D G3DSA:3.40.50.2000 228 373 1.1E-29 T 21-04-2016 SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 PANTHER PTHR11926:SF16 1 369 3.4E-25 T 21-04-2016 SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 276 373 8.1E-17 T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 Gene3D G3DSA:3.40.50.2000 1 176 4.1E-14 T 21-04-2016 SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 PANTHER PTHR11926 1 369 3.4E-25 T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 SUPERFAMILY SSF53756 1 392 2.12E-64 T 21-04-2016 SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 10 391 3.3E-48 T 21-04-2016 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SPH21_RS18485 4e2da08da5562a2c22e55f8ff47bcbed 399 ProSitePatterns PS00221 MIP family signature. 14 22 - T 21-04-2016 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 SPH21_RS19770 250fb81aa132a81dcf6fb8d39318997b 143 Pfam PF05618 Putative ATP-dependant zinc protease 3 139 2.0E-23 T 21-04-2016 SPH21_RS19770 250fb81aa132a81dcf6fb8d39318997b 143 Gene3D G3DSA:2.40.70.10 2 130 5.8E-34 T 21-04-2016 IPR021109 Aspartic peptidase domain SPH21_RS19770 250fb81aa132a81dcf6fb8d39318997b 143 SUPERFAMILY SSF50630 3 135 1.74E-34 T 21-04-2016 IPR021109 Aspartic peptidase domain SPH21_RS19770 250fb81aa132a81dcf6fb8d39318997b 143 PANTHER PTHR38037 3 133 2.1E-26 T 21-04-2016 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 SUPERFAMILY SSF50156 106 199 3.89E-10 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 SUPERFAMILY SSF50156 223 287 6.18E-12 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 Pfam PF00595 PDZ domain (Also known as DHR or GLGF) 223 269 8.7E-7 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 PANTHER PTHR22939:SF78 205 442 9.7E-52 T 21-04-2016 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 Gene3D G3DSA:2.30.42.10 101 199 3.4E-13 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 Gene3D G3DSA:2.30.42.10 223 288 9.7E-15 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 TIGRFAM TIGR00054 TIGR00054: RIP metalloprotease RseP 12 439 1.1E-79 T 21-04-2016 IPR004387 Peptidase M50, putative membrane-associated zinc metallopeptidase GO:0004222|GO:0006508|GO:0016021 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 Pfam PF02163 Peptidase family M50 10 428 1.3E-64 T 21-04-2016 IPR008915 Peptidase M50 GO:0004222|GO:0006508 SPH21_RS14525 6a4e5daa012544fab774759f4423de65 446 PANTHER PTHR22939 205 442 9.7E-52 T 21-04-2016 SPH21_RS11205 db3e55e4cbb630f73588d99eb57acfc7 68 Pfam PF13275 S4 domain 4 67 2.5E-21 T 21-04-2016 SPH21_RS11205 db3e55e4cbb630f73588d99eb57acfc7 68 PANTHER PTHR32319:SF3 5 68 3.0E-16 T 21-04-2016 SPH21_RS11205 db3e55e4cbb630f73588d99eb57acfc7 68 PANTHER PTHR32319 5 68 3.0E-16 T 21-04-2016 SPH21_RS11205 db3e55e4cbb630f73588d99eb57acfc7 68 SUPERFAMILY SSF55174 2 67 2.62E-16 T 21-04-2016 SPH21_RS11205 db3e55e4cbb630f73588d99eb57acfc7 68 Gene3D G3DSA:3.10.290.10 1 67 1.2E-22 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS04130 0cedbd18fe4e50274c8abaf2f4a8a928 579 Pfam PF14322 Starch-binding associating with outer membrane 23 206 5.6E-12 T 21-04-2016 SPH21_RS04130 0cedbd18fe4e50274c8abaf2f4a8a928 579 Pfam PF07980 SusD family 292 579 5.3E-48 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04130 0cedbd18fe4e50274c8abaf2f4a8a928 579 Gene3D G3DSA:1.25.40.10 187 284 5.7E-40 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04130 0cedbd18fe4e50274c8abaf2f4a8a928 579 Gene3D G3DSA:1.25.40.10 348 466 5.7E-40 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04130 0cedbd18fe4e50274c8abaf2f4a8a928 579 SUPERFAMILY SSF48452 17 493 1.39E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04130 0cedbd18fe4e50274c8abaf2f4a8a928 579 SUPERFAMILY SSF48452 547 579 1.39E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 PANTHER PTHR11019 28 268 6.5E-36 T 21-04-2016 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 Gene3D G3DSA:1.10.10.60 215 261 3.0E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 SMART SM00342 177 260 2.4E-23 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 SUPERFAMILY SSF46689 214 261 1.57E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 Pfam PF12833 Helix-turn-helix domain 185 261 5.4E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 Gene3D G3DSA:1.10.10.60 158 214 9.2E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 SUPERFAMILY SSF51182 16 94 1.73E-9 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 SUPERFAMILY SSF46689 159 210 5.2E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 PANTHER PTHR11019:SF53 28 268 6.5E-36 T 21-04-2016 SPH21_RS08695 4777c0d94464a1f839db47acef383fd7 271 Gene3D G3DSA:2.60.120.10 28 92 1.1E-8 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS21280 8c2c1270ecf092f75e282c50fc18d395 166 Pfam PF00034 Cytochrome c 81 165 2.6E-14 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS21280 8c2c1270ecf092f75e282c50fc18d395 166 SUPERFAMILY SSF46626 18 24 3.51E-17 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS21280 8c2c1270ecf092f75e282c50fc18d395 166 SUPERFAMILY SSF46626 74 164 3.51E-17 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS21280 8c2c1270ecf092f75e282c50fc18d395 166 Gene3D G3DSA:1.10.760.10 82 164 1.5E-16 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 SUPERFAMILY SSF51412 8 104 9.03E-126 T 21-04-2016 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 SUPERFAMILY SSF51412 182 460 9.03E-126 T 21-04-2016 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 SMART SM01240 11 476 0.0 T 21-04-2016 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 Pfam PF00571 CBS domain 153 207 4.7E-9 T 21-04-2016 IPR000644 CBS domain SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 Pfam PF00571 CBS domain 97 144 1.6E-10 T 21-04-2016 IPR000644 CBS domain SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 Gene3D G3DSA:3.20.20.70 9 488 3.9E-202 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 PANTHER PTHR11911 11 285 4.1E-240 T 21-04-2016 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 PANTHER PTHR11911 303 487 4.1E-240 T 21-04-2016 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 Hamap MF_01964 Inosine-5'-monophosphate dehydrogenase [guaB]. 12 489 84.707 T 21-04-2016 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: REACT_1698|UniPathway: UPA00601 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 PIRSF PIRSF000130 3 491 1.3E-206 T 21-04-2016 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: REACT_1698|UniPathway: UPA00601 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 12 476 4.4E-162 T 21-04-2016 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 Reactome: REACT_1698 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 ProSitePatterns PS00487 IMP dehydrogenase / GMP reductase signature. 298 310 - T 21-04-2016 IPR015875 IMP dehydrogenase / GMP reductase, conserved site GO:0016491|GO:0055114 Reactome: REACT_1698 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 SMART SM00116 100 148 1.5E-9 T 21-04-2016 IPR000644 CBS domain SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 SMART SM00116 161 209 6.3E-7 T 21-04-2016 IPR000644 CBS domain SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 SUPERFAMILY SSF54631 97 207 1.31E-30 T 21-04-2016 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 PANTHER PTHR11911:SF6 11 285 4.1E-240 T 21-04-2016 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: REACT_1698|UniPathway: UPA00601 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 PANTHER PTHR11911:SF6 303 487 4.1E-240 T 21-04-2016 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: REACT_1698|UniPathway: UPA00601 SPH21_RS18150 5ee0f39e8e697ad088bbbbe2e6745c6a 491 TIGRFAM TIGR01302 IMP_dehydrog: inosine-5'-monophosphate dehydrogenase 12 458 2.2E-189 T 21-04-2016 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: REACT_1698|UniPathway: UPA00601 SPH21_RS15335 08cf564ff9053d6de5cd33afaa08f88f 128 SUPERFAMILY SSF46785 21 120 1.54E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15335 08cf564ff9053d6de5cd33afaa08f88f 128 Gene3D G3DSA:1.10.10.10 12 121 6.5E-40 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15335 08cf564ff9053d6de5cd33afaa08f88f 128 PANTHER PTHR33204 12 115 2.8E-38 T 21-04-2016 SPH21_RS15335 08cf564ff9053d6de5cd33afaa08f88f 128 Pfam PF01638 HxlR-like helix-turn-helix 33 121 6.2E-29 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 TIGRFAM TIGR00086 smpB: SsrA-binding protein 6 148 1.5E-55 T 21-04-2016 IPR000037 SsrA-binding protein GO:0003723 SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 SUPERFAMILY SSF74982 5 130 2.62E-44 T 21-04-2016 IPR023620 Small protein B SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 ProSitePatterns PS01317 SsrA-binding protein. 24 36 - T 21-04-2016 IPR020081 SsrA-binding protein, conserved site SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 Hamap MF_00023 SsrA-binding protein [smpB]. 1 149 61.012 T 21-04-2016 IPR000037 SsrA-binding protein GO:0003723 SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 Gene3D G3DSA:2.40.280.10 6 125 3.8E-46 T 21-04-2016 IPR023620 Small protein B SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 Pfam PF01668 SmpB protein 7 69 1.6E-25 T 21-04-2016 IPR000037 SsrA-binding protein GO:0003723 SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 PANTHER PTHR30308 1 148 1.1E-63 T 21-04-2016 SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 PANTHER PTHR30308:SF2 1 148 1.1E-63 T 21-04-2016 SPH21_RS01560 f702267870d45547734f711f85bb3a46 149 ProDom PD004488 SSRA-BINDING RNA-BINDING SMPB SMALL B TMRNA-BINDING SSRA 3D-STRUCTURE HOMOLOG BINDING 9 130 5.0E-30 T 21-04-2016 IPR000037 SsrA-binding protein GO:0003723 SPH21_RS05180 d00468aea0578ee1751b8c4f8ea0cc34 362 Gene3D G3DSA:3.20.20.70 77 274 2.6E-10 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS05180 d00468aea0578ee1751b8c4f8ea0cc34 362 SUPERFAMILY SSF102114 77 270 6.15E-13 T 21-04-2016 SPH21_RS05180 d00468aea0578ee1751b8c4f8ea0cc34 362 SMART SM00729 73 298 0.0017 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS05180 d00468aea0578ee1751b8c4f8ea0cc34 362 PANTHER PTHR11228:SF26 20 322 2.0E-71 T 21-04-2016 SPH21_RS05180 d00468aea0578ee1751b8c4f8ea0cc34 362 PANTHER PTHR11228 20 322 2.0E-71 T 21-04-2016 SPH21_RS05180 d00468aea0578ee1751b8c4f8ea0cc34 362 Pfam PF04055 Radical SAM superfamily 77 255 1.4E-13 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS09260 495f11f295bfd83cebc72dc56011837a 137 PANTHER PTHR34610:SF3 8 134 2.2E-20 T 21-04-2016 SPH21_RS09260 495f11f295bfd83cebc72dc56011837a 137 PANTHER PTHR34610 8 134 2.2E-20 T 21-04-2016 SPH21_RS09260 495f11f295bfd83cebc72dc56011837a 137 SMART SM00670 5 118 3.3E-6 T 21-04-2016 IPR002716 PIN domain SPH21_RS09260 495f11f295bfd83cebc72dc56011837a 137 TIGRFAM TIGR00305 TIGR00305: putative toxin-antitoxin system toxin component, PIN family 8 119 3.1E-22 T 21-04-2016 IPR002850 PIN family, putative toxin-antitoxin system toxin component SPH21_RS09260 495f11f295bfd83cebc72dc56011837a 137 SUPERFAMILY SSF88723 6 133 3.92E-11 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS09260 495f11f295bfd83cebc72dc56011837a 137 Pfam PF13470 PIN domain 8 114 4.5E-15 T 21-04-2016 IPR002716 PIN domain SPH21_RS26370 5528ca67b14e05b6da6399d32d0a5c28 131 Gene3D G3DSA:1.20.120.20 42 124 5.9E-4 T 21-04-2016 SPH21_RS11980 0945e83a84c0f63eba92ece64a1d7875 126 Gene3D G3DSA:2.40.40.10 57 119 3.3E-6 T 21-04-2016 IPR009009 RlpA-like protein, double-psi beta-barrel domain SPH21_RS11980 0945e83a84c0f63eba92ece64a1d7875 126 SUPERFAMILY SSF50685 24 118 1.12E-13 T 21-04-2016 IPR009009 RlpA-like protein, double-psi beta-barrel domain SPH21_RS11980 0945e83a84c0f63eba92ece64a1d7875 126 PANTHER PTHR34183:SF2 30 119 4.0E-49 T 21-04-2016 SPH21_RS11980 0945e83a84c0f63eba92ece64a1d7875 126 TIGRFAM TIGR00413 rlpA: rare lipoprotein A 33 120 4.9E-42 T 21-04-2016 IPR012997 Rare lipoprotein A SPH21_RS11980 0945e83a84c0f63eba92ece64a1d7875 126 Pfam PF03330 Lytic transglycolase 30 119 1.7E-27 T 21-04-2016 IPR009009 RlpA-like protein, double-psi beta-barrel domain SPH21_RS11980 0945e83a84c0f63eba92ece64a1d7875 126 PANTHER PTHR34183 30 119 4.0E-49 T 21-04-2016 SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 PIRSF PIRSF003078 2 211 5.4E-53 T 21-04-2016 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 Gene3D G3DSA:3.40.50.150 8 210 3.3E-54 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 Hamap MF_00074 Ribosomal RNA small subunit methyltransferase G [rsmG]. 13 208 23.964 T 21-04-2016 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 TIGRFAM TIGR00138 rsmG_gidB: 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG 29 207 1.6E-36 T 21-04-2016 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 PANTHER PTHR31760:SF0 1 184 2.9E-51 T 21-04-2016 SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 Pfam PF02527 rRNA small subunit methyltransferase G 20 184 1.4E-38 T 21-04-2016 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 PANTHER PTHR31760 1 184 2.9E-51 T 21-04-2016 SPH21_RS12510 b002743fa482535f120e8595d0f36f7b 211 SUPERFAMILY SSF53335 8 184 2.52E-36 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 5.4E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 5.4E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 5.4E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 Pfam PF00106 short chain dehydrogenase 2 190 6.1E-57 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PANTHER PTHR24319:SF32 2 238 1.4E-68 T 21-04-2016 SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 SUPERFAMILY SSF51735 1 228 4.24E-67 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 Gene3D G3DSA:3.40.50.720 2 228 2.0E-69 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PANTHER PTHR24319 2 238 1.4E-68 T 21-04-2016 SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 1.4E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 1.4E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 1.4E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 1.4E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25640 398f11fc04191b772d95f5e0c6c0607d 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 1.4E-26 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS09510 dca4b5d5e3d93a29f3ae70849b87039d 447 Gene3D G3DSA:2.30.40.10 74 118 1.7E-7 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09510 dca4b5d5e3d93a29f3ae70849b87039d 447 SUPERFAMILY SSF51338 76 124 1.38E-6 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS09510 dca4b5d5e3d93a29f3ae70849b87039d 447 PANTHER PTHR32027:SF9 47 446 2.8E-130 T 21-04-2016 SPH21_RS09510 dca4b5d5e3d93a29f3ae70849b87039d 447 SUPERFAMILY SSF51556 110 417 1.08E-57 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS09510 dca4b5d5e3d93a29f3ae70849b87039d 447 Gene3D G3DSA:3.20.20.140 119 398 1.4E-78 T 21-04-2016 SPH21_RS09510 dca4b5d5e3d93a29f3ae70849b87039d 447 PANTHER PTHR32027 47 446 2.8E-130 T 21-04-2016 SPH21_RS09510 dca4b5d5e3d93a29f3ae70849b87039d 447 Pfam PF07969 Amidohydrolase family 256 447 2.0E-9 T 21-04-2016 IPR013108 Amidohydrolase 3 SPH21_RS22435 60a56b1afab4c50f9b01bf6263aca0ea 470 SUPERFAMILY SSF48452 19 468 2.78E-86 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22435 60a56b1afab4c50f9b01bf6263aca0ea 470 PANTHER PTHR35148 1 468 5.0E-22 T 21-04-2016 SPH21_RS22435 60a56b1afab4c50f9b01bf6263aca0ea 470 Pfam PF12771 Starch-binding associating with outer membrane 1 457 6.4E-27 T 21-04-2016 SPH21_RS11740 ec3ec2721196ef584598f5ede0f5a735 278 PANTHER PTHR34138:SF1 3 278 2.4E-31 T 21-04-2016 SPH21_RS11740 ec3ec2721196ef584598f5ede0f5a735 278 PIRSF PIRSF038471 7 272 6.2E-37 T 21-04-2016 IPR007221 Rod shape-determining protein MreC GO:0008360 SPH21_RS11740 ec3ec2721196ef584598f5ede0f5a735 278 PANTHER PTHR34138 3 278 2.4E-31 T 21-04-2016 SPH21_RS11740 ec3ec2721196ef584598f5ede0f5a735 278 Pfam PF04085 rod shape-determining protein MreC 111 259 1.4E-34 T 21-04-2016 IPR007221 Rod shape-determining protein MreC GO:0008360 SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 PANTHER PTHR24320 2 298 9.6E-115 T 21-04-2016 SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 Pfam PF00106 short chain dehydrogenase 13 221 4.9E-31 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 Gene3D G3DSA:3.40.50.720 4 250 8.3E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 PANTHER PTHR24320:SF45 2 298 9.6E-115 T 21-04-2016 SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 1.3E-15 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 1.3E-15 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 198 215 1.3E-15 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 14 31 1.3E-15 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 194 1.3E-15 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24015 1fbaaff32ab0abc88f7e15d857b0224d 303 SUPERFAMILY SSF51735 4 251 2.53E-54 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20010 020a2c069e441b819c8ac6cb6cbf8915 624 Gene3D G3DSA:1.10.390.10 407 538 6.5E-15 T 21-04-2016 SPH21_RS20010 020a2c069e441b819c8ac6cb6cbf8915 624 SUPERFAMILY SSF55486 327 533 4.98E-24 T 21-04-2016 SPH21_RS23760 c80b05479d507f10164afe25cc7e92e2 270 Pfam PF07730 Histidine kinase 58 122 2.8E-8 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS23760 c80b05479d507f10164afe25cc7e92e2 270 Pfam PF13581 Histidine kinase-like ATPase domain 156 230 1.3E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23760 c80b05479d507f10164afe25cc7e92e2 270 PANTHER PTHR24421:SF1 44 260 1.7E-17 T 21-04-2016 SPH21_RS23760 c80b05479d507f10164afe25cc7e92e2 270 Gene3D G3DSA:3.30.565.10 139 260 5.5E-8 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23760 c80b05479d507f10164afe25cc7e92e2 270 SUPERFAMILY SSF55874 138 260 1.03E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23760 c80b05479d507f10164afe25cc7e92e2 270 PANTHER PTHR24421 44 260 1.7E-17 T 21-04-2016 SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 PANTHER PTHR23150:SF24 2 383 3.8E-86 T 21-04-2016 SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 Pfam PF12867 DinB superfamily 9 137 3.4E-8 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 TIGRFAM TIGR03440 egtB_TIGR03440: ergothioneine biosynthesis protein EgtB 4 306 1.3E-113 T 21-04-2016 IPR017806 Ergothioneine biosynthesis protein EgtB GO:0052699 KEGG: 00340+1.14.99.50|MetaCyc: PWY-7255|UniPathway: UPA01014 SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 Gene3D G3DSA:3.90.1580.10 161 306 2.4E-34 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 Gene3D G3DSA:3.90.1580.10 311 383 6.7E-15 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 PANTHER PTHR23150 2 383 3.8E-86 T 21-04-2016 SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 Pfam PF03781 Sulfatase-modifying factor enzyme 1 170 305 2.4E-17 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS12725 5d59094bb00ec335ebd160bacc0ad16b 383 SUPERFAMILY SSF56436 171 382 4.24E-59 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 SUPERFAMILY SSF56935 796 841 1.51E-42 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 SUPERFAMILY SSF56935 970 1017 1.51E-42 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 SUPERFAMILY SSF56935 872 908 1.51E-42 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 SUPERFAMILY SSF56935 707 751 1.51E-42 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 SUPERFAMILY SSF56935 354 646 1.51E-42 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 SUPERFAMILY SSF56935 112 311 1.51E-42 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 Gene3D G3DSA:2.40.170.20 968 1019 6.4E-25 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 Gene3D G3DSA:2.40.170.20 480 637 6.4E-25 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 Gene3D G3DSA:2.40.170.20 688 906 6.4E-25 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 Gene3D G3DSA:2.40.170.20 240 445 6.4E-25 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 PANTHER PTHR30069:SF6 1054 1062 1.4E-13 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 PANTHER PTHR30069:SF6 1 359 1.4E-13 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 PANTHER PTHR30069 1054 1062 1.4E-13 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 PANTHER PTHR30069 1 359 1.4E-13 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 Gene3D G3DSA:2.170.130.10 123 239 8.4E-5 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 Pfam PF13620 Carboxypeptidase regulatory-like domain 34 114 3.2E-19 T 21-04-2016 SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 SUPERFAMILY SSF49464 32 124 7.26E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14455 f0dbeb392133498eb87d76dc740f60d7 1063 Gene3D G3DSA:2.60.40.1120 34 122 6.5E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 Pfam PF01546 Peptidase family M20/M25/M40 65 348 3.2E-21 T 21-04-2016 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 Gene3D G3DSA:3.40.630.10 6 178 3.4E-48 T 21-04-2016 SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 Gene3D G3DSA:3.40.630.10 291 351 3.4E-48 T 21-04-2016 SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 Gene3D G3DSA:3.30.70.360 179 267 8.2E-28 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 Pfam PF07687 Peptidase dimerisation domain 166 266 1.1E-15 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 ProSitePatterns PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 64 73 - T 21-04-2016 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 SUPERFAMILY SSF55031 170 269 5.38E-18 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 PANTHER PTHR11014 9 355 1.8E-62 T 21-04-2016 SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 SUPERFAMILY SSF53187 278 349 4.37E-45 T 21-04-2016 SPH21_RS05115 0b85a47248e15db37ea61b7492d096d0 355 SUPERFAMILY SSF53187 2 169 4.37E-45 T 21-04-2016 SPH21_RS24610 94b4db6f78b7f172f162f785d2b44d3a 147 PANTHER PTHR23091 1 137 5.9E-25 T 21-04-2016 SPH21_RS24610 94b4db6f78b7f172f162f785d2b44d3a 147 PANTHER PTHR23091:SF259 1 137 5.9E-25 T 21-04-2016 SPH21_RS24610 94b4db6f78b7f172f162f785d2b44d3a 147 SUPERFAMILY SSF55729 5 139 1.65E-30 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS24610 94b4db6f78b7f172f162f785d2b44d3a 147 Pfam PF00583 Acetyltransferase (GNAT) family 55 136 3.6E-15 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS24610 94b4db6f78b7f172f162f785d2b44d3a 147 Gene3D G3DSA:3.40.630.30 2 141 2.3E-31 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 SMART SM00387 25 179 6.1E-4 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 SUPERFAMILY SSF110942 531 621 3.92E-7 T 21-04-2016 SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PRINTS PR00775 90kDa heat shock protein signature 24 46 1.3E-34 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PRINTS PR00775 90kDa heat shock protein signature 167 184 1.3E-34 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PRINTS PR00775 90kDa heat shock protein signature 185 203 1.3E-34 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PRINTS PR00775 90kDa heat shock protein signature 90 107 1.3E-34 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PRINTS PR00775 90kDa heat shock protein signature 72 89 1.3E-34 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PRINTS PR00775 90kDa heat shock protein signature 116 138 1.3E-34 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 27 152 3.6E-12 T 21-04-2016 SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 Pfam PF00183 Hsp90 protein 212 621 1.0E-54 T 21-04-2016 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PANTHER PTHR11528:SF44 18 611 4.2E-161 T 21-04-2016 SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 SUPERFAMILY SSF54211 236 487 1.52E-68 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PANTHER PTHR11528 18 611 4.2E-161 T 21-04-2016 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 PIRSF PIRSF002583 1 626 2.5E-157 T 21-04-2016 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 SUPERFAMILY SSF55874 1 209 1.19E-55 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16195 7dce9b4ed7e4356dadb9ea6826e884d0 628 Gene3D G3DSA:3.30.565.10 3 243 3.1E-61 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 SUPERFAMILY SSF55186 549 709 5.76E-45 T 21-04-2016 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain GO:0000166 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 Pfam PF02272 DHHA1 domain 801 867 7.6E-9 T 21-04-2016 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 PANTHER PTHR11777:SF9 1 871 0.0 T 21-04-2016 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 SUPERFAMILY SSF101353 254 466 4.45E-62 T 21-04-2016 IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain GO:0000166|GO:0004813|GO:0005524|GO:0005737|GO:0006419 KEGG: 00970+6.1.1.7|Reactome: REACT_71 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 Pfam PF01411 tRNA synthetases class II (A) 5 534 1.5E-198 T 21-04-2016 IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal GO:0000166|GO:0004813|GO:0005524|GO:0006419 KEGG: 00970+6.1.1.7 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 Gene3D G3DSA:3.30.930.10 1 249 1.0E-114 T 21-04-2016 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 SUPERFAMILY SSF55681 2 253 1.99E-100 T 21-04-2016 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 SMART SM00863 650 694 1.5E-17 T 21-04-2016 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 TIGRFAM TIGR00344 alaS: alanine--tRNA ligase 5 853 8.4E-271 T 21-04-2016 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7|Reactome: REACT_71 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 650 694 9.0E-15 T 21-04-2016 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 PANTHER PTHR11777 1 871 0.0 T 21-04-2016 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 Hamap MF_00036_B Alanine--tRNA ligase [alaS]. 1 871 156.397 T 21-04-2016 IPR023033 Alanine-tRNA ligase, eukaryota/bacteria GO:0004813 KEGG: 00970+6.1.1.7 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 PRINTS PR00980 Alanyl-tRNA synthetase signature 308 321 2.8E-29 T 21-04-2016 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7|Reactome: REACT_71 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 PRINTS PR00980 Alanyl-tRNA synthetase signature 74 85 2.8E-29 T 21-04-2016 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7|Reactome: REACT_71 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 PRINTS PR00980 Alanyl-tRNA synthetase signature 284 300 2.8E-29 T 21-04-2016 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7|Reactome: REACT_71 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 PRINTS PR00980 Alanyl-tRNA synthetase signature 234 247 2.8E-29 T 21-04-2016 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7|Reactome: REACT_71 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 PRINTS PR00980 Alanyl-tRNA synthetase signature 207 218 2.8E-29 T 21-04-2016 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7|Reactome: REACT_71 SPH21_RS15455 665c90bbdfcd565807fcbe8784c1f33a 871 SUPERFAMILY SSF50447 456 537 7.06E-16 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 SMART SM01097 7 137 2.0E-72 T 21-04-2016 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00096 Glutamine amidotransferase superfamily signature 339 352 5.7E-12 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00096 Glutamine amidotransferase superfamily signature 252 263 5.7E-12 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00096 Glutamine amidotransferase superfamily signature 224 233 5.7E-12 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 Pfam PF00117 Glutamine amidotransferase class-I 184 361 7.1E-42 T 21-04-2016 IPR017926 Glutamine amidotransferase Reactome: REACT_1698 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 TIGRFAM TIGR01368 CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit 9 364 8.3E-140 T 21-04-2016 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 Gene3D G3DSA:3.50.30.20 8 152 3.7E-52 T 21-04-2016 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 294 305 1.8E-33 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 252 268 1.8E-33 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 269 286 1.8E-33 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 221 235 1.8E-33 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 182 196 1.8E-33 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 Gene3D G3DSA:3.40.50.880 156 363 2.5E-64 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PANTHER PTHR11405 8 363 4.3E-175 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 SUPERFAMILY SSF52021 8 154 5.75E-50 T 21-04-2016 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 Hamap MF_01209 Carbamoyl-phosphate synthase small chain [carA]. 7 366 42.634 T 21-04-2016 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 Pfam PF00988 Carbamoyl-phosphate synthase small chain, CPSase domain 9 136 1.4E-47 T 21-04-2016 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400|UniPathway: UPA00068|UniPathway: UPA00070 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00097 Anthranilate synthase component II signature 339 352 9.5E-7 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00097 Anthranilate synthase component II signature 252 263 9.5E-7 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 PRINTS PR00097 Anthranilate synthase component II signature 224 233 9.5E-7 T 21-04-2016 SPH21_RS01630 2cd8a8889e118f9da49b5625beda9911 366 SUPERFAMILY SSF52317 155 364 2.66E-55 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 Gene3D G3DSA:3.90.1150.10 297 433 1.8E-53 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 SUPERFAMILY SSF53383 7 431 1.77E-123 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 PIRSF PIRSF001434 1 434 2.0E-126 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 PANTHER PTHR11808:SF12 274 434 4.5E-245 T 21-04-2016 IPR006235 O-acetylhomoserine/O-acetylserine sulfhydrylase GO:0006520|GO:0016765 KEGG: 00270+2.5.1.49|MetaCyc: PWY-5344|MetaCyc: PWY-7174 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 PANTHER PTHR11808:SF12 1 238 4.5E-245 T 21-04-2016 IPR006235 O-acetylhomoserine/O-acetylserine sulfhydrylase GO:0006520|GO:0016765 KEGG: 00270+2.5.1.49|MetaCyc: PWY-5344|MetaCyc: PWY-7174 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 TIGRFAM TIGR01326 OAH_OAS_sulfhy: O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase 7 431 2.7E-205 T 21-04-2016 IPR006235 O-acetylhomoserine/O-acetylserine sulfhydrylase GO:0006520|GO:0016765 KEGG: 00270+2.5.1.49|MetaCyc: PWY-5344|MetaCyc: PWY-7174 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 Gene3D G3DSA:3.40.640.10 7 295 5.8E-118 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 PANTHER PTHR11808 274 434 4.5E-245 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 PANTHER PTHR11808 1 238 4.5E-245 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS16840 eb4196914038716a8b410e2385710c3c 434 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 9 431 4.7E-145 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS16875 f15f76219966d551ede66109e4f11ebc 262 Pfam PF01183 Glycosyl hydrolases family 25 64 239 2.5E-43 T 21-04-2016 IPR002053 Glycoside hydrolase, family 25 GO:0003796|GO:0009253|GO:0016998 SPH21_RS16875 f15f76219966d551ede66109e4f11ebc 262 SUPERFAMILY SSF51445 59 251 1.26E-48 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS16875 f15f76219966d551ede66109e4f11ebc 262 SMART SM00641 61 171 2.0E-8 T 21-04-2016 IPR018077 Glycoside hydrolase, family 25 subgroup SPH21_RS16875 f15f76219966d551ede66109e4f11ebc 262 Gene3D G3DSA:3.20.20.80 59 252 3.5E-57 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS16875 f15f76219966d551ede66109e4f11ebc 262 PANTHER PTHR34135 33 255 3.1E-56 T 21-04-2016 SPH21_RS16875 f15f76219966d551ede66109e4f11ebc 262 PANTHER PTHR34135:SF2 33 255 3.1E-56 T 21-04-2016 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 SMART SM00850 142 233 3.8E-21 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 Pfam PF00072 Response regulator receiver domain 4 109 2.7E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 Gene3D G3DSA:2.40.50.40 133 202 2.6E-20 T 21-04-2016 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 SUPERFAMILY SSF52172 2 125 1.85E-24 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 Pfam PF04397 LytTr DNA-binding domain 143 229 1.9E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 SMART SM00448 1 109 9.1E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 Gene3D G3DSA:3.40.50.2300 1 117 8.4E-25 T 21-04-2016 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 PANTHER PTHR26402 1 120 6.6E-26 T 21-04-2016 SPH21_RS23395 524d0f96e79168096ca0de7c99fa6bf1 242 PANTHER PTHR26402:SF522 1 120 6.6E-26 T 21-04-2016 SPH21_RS12660 330abd1b75861d7c7cc4583f86c28530 356 Pfam PF01370 NAD dependent epimerase/dehydratase family 9 235 4.7E-8 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS12660 330abd1b75861d7c7cc4583f86c28530 356 Gene3D G3DSA:3.40.50.720 8 263 2.0E-21 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12660 330abd1b75861d7c7cc4583f86c28530 356 PANTHER PTHR32487 2 356 3.2E-113 T 21-04-2016 SPH21_RS12660 330abd1b75861d7c7cc4583f86c28530 356 PANTHER PTHR32487:SF0 2 356 3.2E-113 T 21-04-2016 SPH21_RS12660 330abd1b75861d7c7cc4583f86c28530 356 SUPERFAMILY SSF51735 8 266 3.12E-30 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12660 330abd1b75861d7c7cc4583f86c28530 356 SUPERFAMILY SSF51735 317 350 3.12E-30 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 149 270 5.6E-6 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 SUPERFAMILY SSF51735 2 167 3.48E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 5 136 3.1E-18 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 Gene3D G3DSA:3.30.360.10 157 377 5.2E-36 T 21-04-2016 SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 PANTHER PTHR22604 1 383 2.8E-63 T 21-04-2016 SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 PANTHER PTHR22604:SF123 1 383 2.8E-63 T 21-04-2016 SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 SUPERFAMILY SSF55347 143 321 3.11E-35 T 21-04-2016 SPH21_RS08010 8fc005ab35d689898a1ecbc8a3c8b30d 385 Gene3D G3DSA:3.40.50.720 1 156 7.5E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 PANTHER PTHR26402 17 146 1.0E-18 T 21-04-2016 SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 SMART SM00850 155 248 7.4E-18 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 Pfam PF04397 LytTr DNA-binding domain 156 243 9.6E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 Pfam PF00072 Response regulator receiver domain 20 124 7.2E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 Gene3D G3DSA:3.40.50.2300 13 136 2.1E-23 T 21-04-2016 SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 Gene3D G3DSA:2.40.50.40 152 214 1.1E-15 T 21-04-2016 SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 SMART SM00448 17 127 1.1E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05375 e37e684c268fba814ce77121c93f6456 257 SUPERFAMILY SSF52172 14 138 1.12E-21 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 219 307 9.0E-24 T 21-04-2016 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 334 432 5.9E-22 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 SMART SM00984 334 432 6.5E-33 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 14 196 1.3E-31 T 21-04-2016 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 Gene3D G3DSA:3.40.50.720 249 433 4.7E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 14 427 2.8E-115 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 SUPERFAMILY SSF48179 218 309 1.11E-24 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 SUPERFAMILY SSF52413 319 433 7.98E-27 T 21-04-2016 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 PANTHER PTHR11374 10 433 3.6E-212 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 SUPERFAMILY SSF51735 15 208 2.93E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 PIRSF PIRSF500136 3 439 2.0E-146 T 21-04-2016 IPR028359 UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase GO:0000271|GO:0016628|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 PANTHER PTHR11374:SF25 10 433 3.6E-212 T 21-04-2016 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 PIRSF PIRSF000124 13 437 8.7E-52 T 21-04-2016 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 SPH21_RS08960 ab556cb69873efbcd2a85eba940f8d86 439 Gene3D G3DSA:3.40.50.720 10 239 6.0E-53 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22970 dfa71f8b2b9b70c58fb3486d772e6850 185 Pfam PF04264 YceI-like domain 57 176 6.9E-8 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS22970 dfa71f8b2b9b70c58fb3486d772e6850 185 SUPERFAMILY SSF101874 29 177 4.97E-17 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS22970 dfa71f8b2b9b70c58fb3486d772e6850 185 Gene3D G3DSA:2.40.128.110 58 178 1.4E-12 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 Gene3D G3DSA:3.20.70.20 347 512 4.4E-55 T 21-04-2016 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 Gene3D G3DSA:3.20.70.20 574 690 4.4E-55 T 21-04-2016 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 Gene3D G3DSA:3.20.70.20 88 294 4.4E-55 T 21-04-2016 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 ProSitePatterns PS00089 Ribonucleotide reductase large subunit signature. 563 585 - T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 TIGRFAM TIGR04170 RNR_1b_NrdE: ribonucleoside-diphosphate reductase, class 1b, alpha subunit 14 705 4.3E-304 T 21-04-2016 IPR026459 Ribonucleotide reductase, class 1b, subunit NrdE KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 Pfam PF08343 Ribonucleotide reductase N-terminal 15 94 4.2E-22 T 21-04-2016 IPR013554 Ribonucleotide reductase N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 SUPERFAMILY SSF51998 172 694 2.29E-170 T 21-04-2016 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 96 166 1.8E-11 T 21-04-2016 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 Pfam PF02867 Ribonucleotide reductase, barrel domain 173 689 3.3E-135 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 SUPERFAMILY SSF48168 14 168 1.26E-37 T 21-04-2016 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 PANTHER PTHR11573 41 702 1.2E-231 T 21-04-2016 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 PRINTS PR01183 Ribonucleotide reductase large chain signature 425 448 9.7E-31 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 PRINTS PR01183 Ribonucleotide reductase large chain signature 381 392 9.7E-31 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 PRINTS PR01183 Ribonucleotide reductase large chain signature 492 515 9.7E-31 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 PRINTS PR01183 Ribonucleotide reductase large chain signature 464 486 9.7E-31 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 PRINTS PR01183 Ribonucleotide reductase large chain signature 248 267 9.7E-31 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 PRINTS PR01183 Ribonucleotide reductase large chain signature 574 601 9.7E-31 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS14490 9ccf27c1e40972b761ab5f54709622bf 705 TIGRFAM TIGR02506 NrdE_NrdA: ribonucleoside-diphosphate reductase, alpha subunit 100 693 1.0E-159 T 21-04-2016 IPR013346 Ribonucleotide reductase, class I , alpha subunit GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 PANTHER PTHR11019 48 305 4.1E-21 T 21-04-2016 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 Gene3D G3DSA:1.10.10.60 253 299 3.9E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 PANTHER PTHR11019:SF45 48 305 4.1E-21 T 21-04-2016 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 SUPERFAMILY SSF46689 253 299 2.15E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 Pfam PF12833 Helix-turn-helix domain 222 298 3.7E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 SMART SM00342 217 298 2.2E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 282 298 7.4E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS13250 a9f25bb020667827f9d669465453bd27 305 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 267 282 7.4E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS20395 2c150adcba52d69c7114cdfae0f02747 474 Pfam PF07690 Major Facilitator Superfamily 24 343 1.2E-16 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS20395 2c150adcba52d69c7114cdfae0f02747 474 Gene3D G3DSA:1.20.1250.20 18 210 2.5E-19 T 21-04-2016 SPH21_RS20395 2c150adcba52d69c7114cdfae0f02747 474 SUPERFAMILY SSF103473 7 352 6.54E-30 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS20395 2c150adcba52d69c7114cdfae0f02747 474 PANTHER PTHR23514 11 321 1.0E-96 T 21-04-2016 SPH21_RS20395 2c150adcba52d69c7114cdfae0f02747 474 PANTHER PTHR23514 372 456 1.0E-96 T 21-04-2016 SPH21_RS20395 2c150adcba52d69c7114cdfae0f02747 474 PANTHER PTHR23514:SF7 11 321 1.0E-96 T 21-04-2016 SPH21_RS20395 2c150adcba52d69c7114cdfae0f02747 474 PANTHER PTHR23514:SF7 372 456 1.0E-96 T 21-04-2016 SPH21_RS25770 e1917001060119c6693279296e351248 68 PANTHER PTHR10031 5 66 1.7E-18 T 21-04-2016 SPH21_RS25770 e1917001060119c6693279296e351248 68 Hamap MF_01396 ATP synthase subunit c [atpH]. 2 67 13.771 T 21-04-2016 SPH21_RS25770 e1917001060119c6693279296e351248 68 Pfam PF00137 ATP synthase subunit C 6 66 2.5E-15 T 21-04-2016 IPR002379 V-ATPase proteolipid subunit C-like domain GO:0015078|GO:0015991|GO:0033177 SPH21_RS25770 e1917001060119c6693279296e351248 68 SUPERFAMILY SSF81333 6 66 6.28E-18 T 21-04-2016 IPR002379 V-ATPase proteolipid subunit C-like domain GO:0015078|GO:0015991|GO:0033177 SPH21_RS25770 e1917001060119c6693279296e351248 68 ProSitePatterns PS00605 ATP synthase c subunit signature. 33 54 - T 21-04-2016 IPR020537 ATPase, F0 complex, subunit C, DCCD-binding site SPH21_RS25770 e1917001060119c6693279296e351248 68 Gene3D G3DSA:1.20.20.10 6 67 2.2E-23 T 21-04-2016 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 SPH21_RS25770 e1917001060119c6693279296e351248 68 TIGRFAM TIGR01260 ATP_synt_c: ATP synthase F0, C subunit 13 66 1.4E-18 T 21-04-2016 IPR005953 ATPase, F0 complex, subunit C, bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 SPH21_RS25770 e1917001060119c6693279296e351248 68 PRINTS PR00124 ATP synthase C subunit signature 5 24 5.669682E-18 T 21-04-2016 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 SPH21_RS25770 e1917001060119c6693279296e351248 68 PRINTS PR00124 ATP synthase C subunit signature 26 41 5.669682E-18 T 21-04-2016 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 SPH21_RS25770 e1917001060119c6693279296e351248 68 PRINTS PR00124 ATP synthase C subunit signature 43 68 5.669682E-18 T 21-04-2016 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 SUPERFAMILY SSF46689 236 287 2.72E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 Gene3D G3DSA:1.10.10.60 237 286 1.3E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 SMART SM00342 200 283 7.1E-25 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 185 229 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 237 279 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 PANTHER PTHR11019 15 291 7.0E-41 T 21-04-2016 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 SUPERFAMILY SSF46689 182 233 1.25E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 Pfam PF12833 Helix-turn-helix domain 207 284 1.1E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 PANTHER PTHR11019:SF50 15 291 7.0E-41 T 21-04-2016 SPH21_RS04550 1b12a8a803fb2bab91f69ef175a57b12 293 Gene3D G3DSA:1.10.10.60 180 236 1.4E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 PANTHER PTHR11846 5 423 2.3E-179 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 ProSitePatterns PS01266 Adenylosuccinate synthetase GTP-binding site. 10 17 - T 21-04-2016 IPR018220 Adenylosuccinate synthase, GTP-binding site GO:0005525 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 Pfam PF00709 Adenylosuccinate synthetase 5 421 3.2E-153 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 Gene3D G3DSA:3.40.440.10 195 266 2.2E-62 T 21-04-2016 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 Gene3D G3DSA:3.40.440.10 1 93 2.2E-62 T 21-04-2016 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 TIGRFAM TIGR00184 purA: adenylosuccinate synthase 5 421 2.4E-141 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 Gene3D G3DSA:3.90.170.10 267 422 2.2E-54 T 21-04-2016 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 PANTHER PTHR11846:SF0 5 423 2.3E-179 T 21-04-2016 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 Gene3D G3DSA:1.10.300.10 104 194 1.3E-27 T 21-04-2016 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 Hamap MF_00011 Adenylosuccinate synthetase [purA]. 1 423 153.527 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 SUPERFAMILY SSF52540 1 421 4.25E-142 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23300 00d10e1e871dbda01efb03d42a07a485 423 SMART SM00788 3 422 2.8E-213 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS17140 e4367ed9ee0a7a613634eaddeb58b11d 135 PANTHER PTHR39624:SF2 1 135 2.3E-41 T 21-04-2016 SPH21_RS17140 e4367ed9ee0a7a613634eaddeb58b11d 135 Gene3D G3DSA:3.30.300.20 5 133 2.5E-36 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS17140 e4367ed9ee0a7a613634eaddeb58b11d 135 PANTHER PTHR39624 1 135 2.3E-41 T 21-04-2016 SPH21_RS17140 e4367ed9ee0a7a613634eaddeb58b11d 135 SUPERFAMILY SSF82784 11 133 9.03E-33 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS17140 e4367ed9ee0a7a613634eaddeb58b11d 135 Pfam PF02566 OsmC-like protein 36 130 5.9E-18 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS06820 f455503253f27ad52cba491afe2f7ff4 220 PANTHER PTHR20857 1 215 4.3E-52 T 21-04-2016 SPH21_RS06820 f455503253f27ad52cba491afe2f7ff4 220 Hamap MF_00097 Thiamine-phosphate synthase [thiE]. 9 213 22.569 T 21-04-2016 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357|UniPathway: UPA00060 SPH21_RS06820 f455503253f27ad52cba491afe2f7ff4 220 TIGRFAM TIGR00693 thiE: thiamine-phosphate diphosphorylase 14 207 3.7E-50 T 21-04-2016 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357|UniPathway: UPA00060 SPH21_RS06820 f455503253f27ad52cba491afe2f7ff4 220 PANTHER PTHR20857:SF15 1 215 4.3E-52 T 21-04-2016 SPH21_RS06820 f455503253f27ad52cba491afe2f7ff4 220 Gene3D G3DSA:3.20.20.70 10 214 4.1E-59 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS06820 f455503253f27ad52cba491afe2f7ff4 220 Pfam PF02581 Thiamine monophosphate synthase/TENI 14 192 4.0E-52 T 21-04-2016 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357|UniPathway: UPA00060 SPH21_RS06820 f455503253f27ad52cba491afe2f7ff4 220 SUPERFAMILY SSF51391 12 212 1.2E-52 T 21-04-2016 IPR022998 Thiamin phosphate synthase superfamily KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357|UniPathway: UPA00060 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 SUPERFAMILY SSF55831 1 273 6.54E-130 T 21-04-2016 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 PRINTS PR00108 Thymidylate synthase family signature 206 223 4.4E-50 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 PRINTS PR00108 Thymidylate synthase family signature 42 63 4.4E-50 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 PRINTS PR00108 Thymidylate synthase family signature 115 134 4.4E-50 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 PRINTS PR00108 Thymidylate synthase family signature 168 194 4.4E-50 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 PRINTS PR00108 Thymidylate synthase family signature 141 156 4.4E-50 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 TIGRFAM TIGR03284 thym_sym: thymidylate synthase 84 273 3.3E-93 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 TIGRFAM TIGR03284 thym_sym: thymidylate synthase 2 85 8.7E-43 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 PANTHER PTHR11548 1 273 1.8E-191 T 21-04-2016 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 Hamap MF_00008 Thymidylate synthase [thyA]. 1 273 46.096 T 21-04-2016 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 ProSitePatterns PS00091 Thymidylate synthase active site. 126 154 - T 21-04-2016 IPR020940 Thymidylate synthase, active site GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 Pfam PF00303 Thymidylate synthase 2 273 4.6E-126 T 21-04-2016 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS14800 d2e5c5aa20d7278b25f37165992832a6 273 Gene3D G3DSA:3.30.572.10 1 273 8.5E-135 T 21-04-2016 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|UniPathway: UPA00575 SPH21_RS17790 b6cf9986df773898ce173c5d0c15e837 110 Pfam PF13571 Domain of unknown function (DUF4133) 6 95 1.8E-38 T 21-04-2016 IPR025407 Protein of unknown function DUF4133 SPH21_RS08855 5f3bd7b610cdb9eb57876daf4b42855c 197 Gene3D G3DSA:2.160.10.10 41 193 1.8E-38 T 21-04-2016 SPH21_RS08855 5f3bd7b610cdb9eb57876daf4b42855c 197 PANTHER PTHR23416:SF58 69 196 2.8E-29 T 21-04-2016 SPH21_RS08855 5f3bd7b610cdb9eb57876daf4b42855c 197 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 133 168 1.6E-9 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS08855 5f3bd7b610cdb9eb57876daf4b42855c 197 PANTHER PTHR23416 69 196 2.8E-29 T 21-04-2016 SPH21_RS08855 5f3bd7b610cdb9eb57876daf4b42855c 197 SUPERFAMILY SSF51161 69 187 8.04E-33 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 Gene3D G3DSA:1.10.10.10 122 186 1.3E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 Pfam PF08281 Sigma-70, region 4 130 169 3.7E-11 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 Gene3D G3DSA:1.10.1740.10 2 109 1.2E-28 T 21-04-2016 SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 SUPERFAMILY SSF88659 118 185 1.21E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 184 4.2E-28 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 PANTHER PTHR30173 1 185 7.2E-46 T 21-04-2016 SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 Pfam PF04542 Sigma-70 region 2 26 96 2.3E-14 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02755 3741df5a99112d7a69750ffd6ff67c1e 195 SUPERFAMILY SSF88946 4 105 1.24E-25 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 SUPERFAMILY SSF47384 134 209 4.32E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 SMART SM00388 144 209 1.0E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 Gene3D G3DSA:3.40.50.2300 5 125 2.4E-21 T 21-04-2016 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 Gene3D G3DSA:3.30.565.10 215 361 5.2E-33 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 SUPERFAMILY SSF52172 4 130 1.99E-20 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 Pfam PF00512 His Kinase A (phospho-acceptor) domain 145 203 8.7E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 SMART SM00448 5 118 2.5E-12 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 SMART SM00387 252 362 2.8E-16 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 SUPERFAMILY SSF55874 209 360 2.36E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 Gene3D G3DSA:1.10.287.130 137 203 5.6E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 PRINTS PR00344 Bacterial sensor protein C-terminal signature 310 320 8.3E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 PRINTS PR00344 Bacterial sensor protein C-terminal signature 292 306 8.3E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 PRINTS PR00344 Bacterial sensor protein C-terminal signature 323 341 8.3E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 PRINTS PR00344 Bacterial sensor protein C-terminal signature 347 360 8.3E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 Pfam PF00072 Response regulator receiver domain 7 118 9.1E-12 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 PANTHER PTHR24423 135 360 2.7E-48 T 21-04-2016 SPH21_RS10070 bcaa0f424dd75d3a291b3c02d3492ec8 362 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 253 361 5.3E-16 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15555 4f131d093349bdaae67e84688919772d 126 Gene3D G3DSA:3.10.180.10 5 121 2.7E-26 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS15555 4f131d093349bdaae67e84688919772d 126 SUPERFAMILY SSF54593 6 121 4.56E-22 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS15555 4f131d093349bdaae67e84688919772d 126 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 7 116 8.1E-12 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS19270 f88ff5aed927e0dd88a309c275aec9e7 491 Gene3D G3DSA:1.25.40.10 206 436 1.7E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19270 f88ff5aed927e0dd88a309c275aec9e7 491 SUPERFAMILY SSF48452 28 491 2.15E-111 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19270 f88ff5aed927e0dd88a309c275aec9e7 491 Pfam PF07980 SusD family 216 491 5.7E-36 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 28 176 3.1E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 Pfam PF04542 Sigma-70 region 2 33 96 4.0E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 28 177 1.0E-37 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 SUPERFAMILY SSF88659 119 184 2.06E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 SUPERFAMILY SSF88946 13 112 2.98E-20 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 55 86 - T 21-04-2016 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 PANTHER PTHR30173 4 194 1.1E-44 T 21-04-2016 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 Gene3D G3DSA:1.10.1740.10 14 113 4.1E-21 T 21-04-2016 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 Gene3D G3DSA:1.10.10.10 126 184 3.0E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 Pfam PF08281 Sigma-70, region 4 127 174 1.3E-14 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23200 f5fc419dc4518bcfba9173bb2019f6f1 198 PANTHER PTHR30173:SF20 4 194 1.1E-44 T 21-04-2016 SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 PANTHER PTHR10629 77 407 8.7E-57 T 21-04-2016 SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 ProSitePatterns PS00094 C-5 cytosine-specific DNA methylases active site. 148 160 - T 21-04-2016 IPR018117 DNA methylase, C-5 cytosine-specific, active site KEGG: 00270+2.1.1.37 SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 Gene3D G3DSA:3.40.50.150 84 264 1.1E-59 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 SUPERFAMILY SSF53335 80 407 3.23E-87 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 Pfam PF00145 C-5 cytosine-specific DNA methylase 85 403 9.1E-98 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 187 201 1.7E-17 T 21-04-2016 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 86 102 1.7E-17 T 21-04-2016 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 235 248 1.7E-17 T 21-04-2016 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 Gene3D G3DSA:3.90.120.10 265 390 4.0E-25 T 21-04-2016 SPH21_RS04430 0d2f6a465293c1c426fbaeb8b32229cd 409 TIGRFAM TIGR00675 dcm: DNA (cytosine-5-)-methyltransferase 87 402 3.9E-93 T 21-04-2016 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Pfam PF13715 CarboxypepD_reg-like domain 34 113 1.4E-14 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 SUPERFAMILY SSF49464 32 111 9.16E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Gene3D G3DSA:2.170.130.10 123 231 3.6E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 32 1025 9.5E-265 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 204 234 2.3E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 PANTHER PTHR11532 2 370 1.6E-253 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 PANTHER PTHR11532 435 1023 1.6E-253 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 PANTHER PTHR11532:SF57 2 370 1.6E-253 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 PANTHER PTHR11532:SF57 435 1023 1.6E-253 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Gene3D G3DSA:2.40.170.20 325 800 3.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Gene3D G3DSA:2.40.170.20 917 1025 3.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Gene3D G3DSA:2.40.170.20 853 878 3.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Gene3D G3DSA:2.40.170.20 232 257 3.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 SUPERFAMILY SSF56935 844 888 8.79E-98 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 SUPERFAMILY SSF56935 109 252 8.79E-98 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 SUPERFAMILY SSF56935 316 404 8.79E-98 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 SUPERFAMILY SSF56935 435 771 8.79E-98 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 SUPERFAMILY SSF56935 927 1025 8.79E-98 T 21-04-2016 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Gene3D G3DSA:2.60.40.1120 34 122 1.5E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Pfam PF07715 TonB-dependent Receptor Plug Domain 121 228 5.9E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14205 984cfed9e9e4c6a69d3b6fba20d7299b 1025 Pfam PF00593 TonB dependent receptor 608 1024 1.1E-24 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 SUPERFAMILY SSF55545 17 145 1.18E-22 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PANTHER PTHR22600:SF21 1 207 2.6E-228 T 21-04-2016 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PANTHER PTHR22600:SF21 227 573 2.6E-228 T 21-04-2016 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 147 494 1.7E-126 T 21-04-2016 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PANTHER PTHR22600 1 207 2.6E-228 T 21-04-2016 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PANTHER PTHR22600 227 573 2.6E-228 T 21-04-2016 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 106 126 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 313 326 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 170 191 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 291 309 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 476 493 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 141 158 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 244 261 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 PRINTS PR00738 Glycosyl hydrolase family 20 signature 458 474 7.9E-48 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 25 144 1.3E-23 T 21-04-2016 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 Gene3D G3DSA:3.30.379.10 3 144 6.1E-31 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 SUPERFAMILY SSF51445 147 504 1.93E-130 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS03260 db661e1e387699cf4bd2a6a501c21ec0 608 Gene3D G3DSA:3.20.20.80 145 558 2.0E-142 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 SUPERFAMILY SSF50615 3 78 8.11E-25 T 21-04-2016 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 Gene3D G3DSA:2.40.10.170 2 78 1.8E-33 T 21-04-2016 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 368 377 - T 21-04-2016 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 SMART SM00382 145 440 2.9E-6 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 TIGRFAM TIGR01039 atpD: ATP synthase F1, beta subunit 4 495 1.6E-238 T 21-04-2016 IPR005722 ATPase, F1 complex, beta subunit GO:0015986|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 SUPERFAMILY SSF52540 80 204 4.58E-83 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 SUPERFAMILY SSF52540 232 382 4.58E-83 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 7 76 8.2E-24 T 21-04-2016 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 PANTHER PTHR15184:SF8 230 499 0.0 T 21-04-2016 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 PANTHER PTHR15184:SF8 1 203 0.0 T 21-04-2016 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 Hamap MF_01347 ATP synthase subunit beta [atpB]. 2 495 56.208 T 21-04-2016 IPR005722 ATPase, F1 complex, beta subunit GO:0015986|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 133 377 7.3E-59 T 21-04-2016 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 PANTHER PTHR15184 230 499 0.0 T 21-04-2016 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 PANTHER PTHR15184 1 203 0.0 T 21-04-2016 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 Gene3D G3DSA:3.40.50.300 80 379 4.4E-103 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 Gene3D G3DSA:1.10.1140.10 381 498 1.5E-51 T 21-04-2016 IPR024034 ATPase, F1 complex beta subunit/V1 complex, C-terminal KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS11290 940c7fc118a7ed1710d6da955d332e0a 501 SUPERFAMILY SSF47917 380 494 1.07E-50 T 21-04-2016 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS10210 c8153ac3329772f317ff42a321865894 399 SUPERFAMILY SSF53756 1 395 2.48E-70 T 21-04-2016 SPH21_RS10210 c8153ac3329772f317ff42a321865894 399 Pfam PF13439 Glycosyltransferase Family 4 16 205 1.9E-19 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS10210 c8153ac3329772f317ff42a321865894 399 Pfam PF00534 Glycosyl transferases group 1 220 371 1.2E-29 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS10210 c8153ac3329772f317ff42a321865894 399 PANTHER PTHR12526 1 395 5.6E-46 T 21-04-2016 SPH21_RS10210 c8153ac3329772f317ff42a321865894 399 Gene3D G3DSA:3.40.50.2000 221 371 5.0E-30 T 21-04-2016 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 SMART SM00631 43 318 0.0047 T 21-04-2016 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 ProSitePatterns PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 121 143 - T 21-04-2016 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 SUPERFAMILY SSF53187 118 338 1.16E-35 T 21-04-2016 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 SUPERFAMILY SSF53187 44 89 1.16E-35 T 21-04-2016 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 PANTHER PTHR11705:SF77 105 209 2.8E-18 T 21-04-2016 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 PANTHER PTHR11705:SF77 37 81 2.8E-18 T 21-04-2016 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 Pfam PF00246 Zinc carboxypeptidase 54 363 5.0E-33 T 21-04-2016 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 Gene3D G3DSA:3.40.630.10 42 212 3.5E-20 T 21-04-2016 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 PANTHER PTHR11705 105 209 2.8E-18 T 21-04-2016 SPH21_RS13745 4d1ec85357432a649d450d4b41de70cb 904 PANTHER PTHR11705 37 81 2.8E-18 T 21-04-2016 SPH21_RS16540 2eec301da7abded31be4dbb6fbcfc651 250 SUPERFAMILY SSF64167 1 241 1.29E-70 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS16540 2eec301da7abded31be4dbb6fbcfc651 250 PANTHER PTHR30457 1 240 3.9E-73 T 21-04-2016 SPH21_RS16540 2eec301da7abded31be4dbb6fbcfc651 250 Gene3D G3DSA:3.40.1210.10 1 241 1.3E-74 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS16540 2eec301da7abded31be4dbb6fbcfc651 250 TIGRFAM TIGR00087 surE: 5'/3'-nucleotidase SurE 1 230 2.8E-55 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS16540 2eec301da7abded31be4dbb6fbcfc651 250 Pfam PF01975 Survival protein SurE 3 180 3.9E-48 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS16540 2eec301da7abded31be4dbb6fbcfc651 250 Hamap MF_00060 5'/3'-nucleotidase SurE [surE]. 1 247 31.279 T 21-04-2016 IPR030048 Survival protein SurE GO:0008252 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 SUPERFAMILY SSF55129 3 57 1.83E-19 T 21-04-2016 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 Pfam PF00327 Ribosomal protein L30p/L7e 4 54 3.1E-21 T 21-04-2016 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 TIGRFAM TIGR01308 rpmD_bact: ribosomal protein uL30 4 57 4.2E-22 T 21-04-2016 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 Gene3D G3DSA:3.30.1390.20 1 57 2.1E-26 T 21-04-2016 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 PANTHER PTHR15892 1 57 4.5E-19 T 21-04-2016 SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 PANTHER PTHR15892:SF2 1 57 4.5E-19 T 21-04-2016 SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 PIRSF PIRSF002211 1 59 7.1E-24 T 21-04-2016 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS08585 523f930a520f69ac8dab7b806cd77cc6 59 Hamap MF_01371_B 50S ribosomal protein L30 [rpmD]. 1 58 17.634 T 21-04-2016 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS18880 f5986bace07791982b4874c694acd2f3 171 PANTHER PTHR30565:SF2 16 168 6.9E-47 T 21-04-2016 SPH21_RS18880 f5986bace07791982b4874c694acd2f3 171 PANTHER PTHR30565 16 168 6.9E-47 T 21-04-2016 SPH21_RS18880 f5986bace07791982b4874c694acd2f3 171 SUPERFAMILY SSF47240 11 163 1.76E-53 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS18880 f5986bace07791982b4874c694acd2f3 171 Gene3D G3DSA:1.20.1260.10 10 168 2.4E-63 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS18880 f5986bace07791982b4874c694acd2f3 171 Pfam PF05974 Domain of unknown function (DUF892) 16 168 7.1E-56 T 21-04-2016 IPR010287 Domain of unknown function DUF892 SPH21_RS08380 21b09e23d98802f694990e35d5681e77 644 Pfam PF00884 Sulfatase 272 545 1.3E-32 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS08380 21b09e23d98802f694990e35d5681e77 644 Gene3D G3DSA:3.40.720.10 272 550 1.1E-33 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS08380 21b09e23d98802f694990e35d5681e77 644 PIRSF PIRSF005091 15 642 5.5E-82 T 21-04-2016 IPR012160 Lipoteichoic acid synthase-like KEGG: 00440+2.7.8.-|KEGG: 00513+2.7.8.-|KEGG: 00540+2.7.8.-|KEGG: 00564+2.7.8.-|KEGG: 00600+2.7.8.-|KEGG: 00770+2.7.8.-|UniPathway: UPA00556 SPH21_RS08380 21b09e23d98802f694990e35d5681e77 644 PANTHER PTHR10342 233 624 1.8E-47 T 21-04-2016 SPH21_RS08380 21b09e23d98802f694990e35d5681e77 644 Gene3D G3DSA:3.30.1120.10 567 636 8.8E-9 T 21-04-2016 SPH21_RS08380 21b09e23d98802f694990e35d5681e77 644 SUPERFAMILY SSF53649 269 638 5.82E-55 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS08380 21b09e23d98802f694990e35d5681e77 644 PANTHER PTHR10342:SF236 233 624 1.8E-47 T 21-04-2016 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 Pfam PF01872 RibD C-terminal domain 155 312 1.7E-29 T 21-04-2016 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 PANTHER PTHR11079:SF10 5 227 1.6E-54 T 21-04-2016 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 Gene3D G3DSA:3.40.430.10 136 311 4.5E-49 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 51 96 - T 21-04-2016 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 SUPERFAMILY SSF53927 4 152 5.38E-41 T 21-04-2016 IPR016193 Cytidine deaminase-like GO:0003824 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 PANTHER PTHR11079 5 227 1.6E-54 T 21-04-2016 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 2 107 8.0E-17 T 21-04-2016 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 Gene3D G3DSA:3.40.140.10 4 135 2.2E-27 T 21-04-2016 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 SUPERFAMILY SSF53597 155 327 1.8E-38 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 PIRSF PIRSF006769 1 337 3.4E-102 T 21-04-2016 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00040+1.1.1.19|KEGG: 00053+1.1.1.19|KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-5525|UniPathway: UPA00275|UniPathway: UPA00275 SPH21_RS16885 35e0f3253a8f58ec7e02d8ac4ed9bf71 348 TIGRFAM TIGR00326 eubact_ribD: riboflavin biosynthesis protein RibD 8 309 8.0E-83 T 21-04-2016 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00040+1.1.1.19|KEGG: 00053+1.1.1.19|KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-5525|UniPathway: UPA00275|UniPathway: UPA00275 SPH21_RS23120 a6832a54345003c1a5d74e8acfb59112 272 Pfam PF12872 OST-HTH/LOTUS domain 189 248 3.4E-15 T 21-04-2016 IPR025605 OST-HTH/LOTUS domain SPH21_RS23120 a6832a54345003c1a5d74e8acfb59112 272 PANTHER PTHR35811:SF1 3 262 4.7E-55 T 21-04-2016 SPH21_RS23120 a6832a54345003c1a5d74e8acfb59112 272 PANTHER PTHR35811 3 262 4.7E-55 T 21-04-2016 SPH21_RS23120 a6832a54345003c1a5d74e8acfb59112 272 Gene3D G3DSA:3.40.50.1010 5 146 2.4E-30 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS23120 a6832a54345003c1a5d74e8acfb59112 272 Pfam PF01936 NYN domain 12 146 3.8E-30 T 21-04-2016 IPR021139 NYN domain, limkain-b1-type SPH21_RS03085 328676275af26b0b0e71022038a5141f 285 PANTHER PTHR11820:SF71 1 283 2.4E-127 T 21-04-2016 SPH21_RS03085 328676275af26b0b0e71022038a5141f 285 Gene3D G3DSA:3.90.850.10 67 281 5.5E-88 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS03085 328676275af26b0b0e71022038a5141f 285 SUPERFAMILY SSF56529 63 280 1.83E-79 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS03085 328676275af26b0b0e71022038a5141f 285 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 74 279 4.3E-67 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS03085 328676275af26b0b0e71022038a5141f 285 PANTHER PTHR11820 1 283 2.4E-127 T 21-04-2016 SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 SUPERFAMILY SSF52540 349 576 1.52E-63 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 SUPERFAMILY SSF90123 22 331 2.09E-75 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 PANTHER PTHR24221 12 574 5.4E-159 T 21-04-2016 SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 Pfam PF00005 ABC transporter 367 519 2.4E-29 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 Pfam PF00664 ABC transporter transmembrane region 35 305 1.3E-54 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 SMART SM00382 376 565 4.6E-14 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 ProSitePatterns PS00211 ABC transporters family signature. 491 505 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 Gene3D G3DSA:1.20.1560.10 24 331 8.8E-78 T 21-04-2016 SPH21_RS18720 03f61f03607e3faa219879cce72cf13f 586 Gene3D G3DSA:3.40.50.300 350 577 2.0E-63 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06500 2379e7dca6ea07bc24de408fa60ab8c6 204 SUPERFAMILY SSF53167 3 187 2.62E-23 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS06500 2379e7dca6ea07bc24de408fa60ab8c6 204 Gene3D G3DSA:3.40.50.1580 2 202 3.2E-33 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS06500 2379e7dca6ea07bc24de408fa60ab8c6 204 Pfam PF01048 Phosphorylase superfamily 26 188 1.7E-11 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS06500 2379e7dca6ea07bc24de408fa60ab8c6 204 Hamap MF_00991 Futalosine hydrolase [mqnB]. 17 204 23.443 T 21-04-2016 IPR019963 Futalosine hydrolase GO:0009234|GO:0016799 KEGG: 00130+3.2.2.26|MetaCyc: PWY-7374|UniPathway: UPA00079 SPH21_RS06500 2379e7dca6ea07bc24de408fa60ab8c6 204 TIGRFAM TIGR03664 fut_nucase: futalosine hydrolase 5 202 3.0E-48 T 21-04-2016 IPR019963 Futalosine hydrolase GO:0009234|GO:0016799 KEGG: 00130+3.2.2.26|MetaCyc: PWY-7374|UniPathway: UPA00079 SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 TIGRFAM TIGR03804 para_beta_helix: parallel beta-helix repeat 211 254 1.1E-7 T 21-04-2016 IPR022441 Parallel beta-helix repeat-2 SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SUPERFAMILY SSF51126 13 116 8.75E-36 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SUPERFAMILY SSF51126 144 384 8.75E-36 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 Gene3D G3DSA:2.160.20.10 19 444 2.4E-37 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SUPERFAMILY SSF51126 375 562 1.29E-8 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SMART SM00710 155 182 3900.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SMART SM00710 240 262 82.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SMART SM00710 484 505 7200.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SMART SM00710 183 216 3900.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SMART SM00710 460 482 1100.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SMART SM00710 268 290 500.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 SMART SM00710 217 239 0.094 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS10195 2b1688ec843d38c8e0e6b202b6918c22 582 Pfam PF12708 Pectate lyase superfamily protein 48 290 1.7E-13 T 21-04-2016 IPR024535 Pectate lyase superfamily protein SPH21_RS13400 41cba9f6badee1e1026f48c9198cd9b7 510 Gene3D G3DSA:3.30.750.24 407 489 2.1E-9 T 21-04-2016 IPR002645 STAS domain SPH21_RS13400 41cba9f6badee1e1026f48c9198cd9b7 510 PANTHER PTHR11814 9 490 1.2E-142 T 21-04-2016 IPR001902 SLC26A/SulP transporter GO:0008271|GO:0008272|GO:0016020|GO:0055085 Reactome: REACT_15518 SPH21_RS13400 41cba9f6badee1e1026f48c9198cd9b7 510 SUPERFAMILY SSF52091 408 488 2.94E-11 T 21-04-2016 IPR002645 STAS domain SPH21_RS13400 41cba9f6badee1e1026f48c9198cd9b7 510 PANTHER PTHR11814:SF76 9 490 1.2E-142 T 21-04-2016 SPH21_RS13400 41cba9f6badee1e1026f48c9198cd9b7 510 Pfam PF00916 Sulfate permease family 16 363 3.8E-51 T 21-04-2016 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 SPH21_RS13400 41cba9f6badee1e1026f48c9198cd9b7 510 Pfam PF01740 STAS domain 408 489 4.7E-6 T 21-04-2016 IPR002645 STAS domain SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PRINTS PR00132 Glycosyl hydrolase family 2 signature 413 431 1.1E-36 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PRINTS PR00132 Glycosyl hydrolase family 2 signature 483 498 1.1E-36 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PRINTS PR00132 Glycosyl hydrolase family 2 signature 172 187 1.1E-36 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PRINTS PR00132 Glycosyl hydrolase family 2 signature 552 567 1.1E-36 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PRINTS PR00132 Glycosyl hydrolase family 2 signature 382 396 1.1E-36 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Pfam PF00703 Glycosyl hydrolases family 2 248 371 5.3E-17 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 SUPERFAMILY SSF49303 247 371 1.61E-19 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 SUPERFAMILY SSF49303 645 755 1.08E-26 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 SUPERFAMILY SSF49785 25 246 8.14E-64 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 ProSitePatterns PS00719 Glycosyl hydrolases family 2 signature 1. 423 448 - T 21-04-2016 IPR023230 Glycoside hydrolase, family 2, conserved site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Gene3D G3DSA:2.60.120.260 19 234 3.2E-80 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 SUPERFAMILY SSF74650 769 1058 1.41E-76 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Gene3D G3DSA:2.70.98.10 771 1058 8.9E-85 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PANTHER PTHR10066 618 1058 0.0 T 21-04-2016 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PANTHER PTHR10066 3 597 0.0 T 21-04-2016 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 66 245 1.4E-41 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 ProSitePatterns PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 483 497 - T 21-04-2016 IPR023232 Glycoside hydrolase, family 2, active site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 SMART SM01038 781 1057 4.7E-97 T 21-04-2016 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 SUPERFAMILY SSF51445 373 649 3.91E-92 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Pfam PF02929 Beta galactosidase small chain 784 1056 3.6E-71 T 21-04-2016 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 373 652 2.3E-100 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PANTHER PTHR10066:SF72 618 1058 0.0 T 21-04-2016 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 PANTHER PTHR10066:SF72 3 597 0.0 T 21-04-2016 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Gene3D G3DSA:3.20.20.80 372 648 5.8E-106 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Gene3D G3DSA:2.60.40.320 649 757 1.3E-27 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Gene3D G3DSA:2.60.40.320 235 371 4.4E-29 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS08690 07c5eca0a815b402b260d250a3bf51a7 1073 Pfam PF16353 Domain of unknown function(DUF4981) 663 751 5.4E-21 T 21-04-2016 IPR032312 Beta-galactosidase, domain 4 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11000 54e56cc92cebe3e3e4dcfa854e643c88 108 SMART SM00712 11 79 0.0013 T 21-04-2016 IPR006628 Purine-rich element binding protein family SPH21_RS11000 54e56cc92cebe3e3e4dcfa854e643c88 108 Pfam PF11680 Protein of unknown function (DUF3276) 5 95 2.3E-35 T 21-04-2016 IPR021694 Protein of unknown function DUF3276 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 Hamap MF_00580 10 kDa chaperonin [groS]. 4 91 23.187 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 Gene3D G3DSA:2.30.33.40 4 91 1.9E-35 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 PRINTS PR00297 10kDa chaperonin signature 57 69 1.3E-31 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 PRINTS PR00297 10kDa chaperonin signature 78 91 1.3E-31 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 PRINTS PR00297 10kDa chaperonin signature 5 20 1.3E-31 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 PRINTS PR00297 10kDa chaperonin signature 27 48 1.3E-31 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 Pfam PF00166 Chaperonin 10 Kd subunit 5 91 8.5E-34 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 ProSitePatterns PS00681 Chaperonins cpn10 signature. 5 29 - T 21-04-2016 IPR018369 Chaperonin GroES, conserved site GO:0005524|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 SUPERFAMILY SSF50129 3 91 3.07E-33 T 21-04-2016 IPR011032 GroES-like SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 SMART SM00883 4 91 3.8E-52 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 PANTHER PTHR10772 4 91 4.6E-43 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS03710 92bf5c3c2b1ca8acf4f243ac86a8ed16 91 PANTHER PTHR10772:SF0 4 91 4.6E-43 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 Gene3D G3DSA:3.30.300.30 499 622 3.6E-4 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 PANTHER PTHR24096 3 631 2.9E-171 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 ProSitePatterns PS00455 Putative AMP-binding domain signature. 195 206 - T 21-04-2016 IPR020845 AMP-binding, conserved site SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 SUPERFAMILY SSF56801 8 299 1.44E-111 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 SUPERFAMILY SSF56801 350 632 1.44E-111 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 Gene3D G3DSA:3.40.50.980 180 201 1.1E-33 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 Gene3D G3DSA:3.40.50.980 7 147 1.1E-33 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 Gene3D G3DSA:2.30.38.10 410 491 1.2E-21 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 Pfam PF00501 AMP-binding enzyme 28 500 2.0E-100 T 21-04-2016 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 Gene3D G3DSA:3.40.50.980 202 294 2.0E-36 T 21-04-2016 SPH21_RS16475 e1c6ebeeb5ed59ff5a022aedabf2330c 633 Gene3D G3DSA:3.40.50.980 347 409 2.0E-36 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 Pfam PF00732 GMC oxidoreductase 184 312 1.4E-8 T 21-04-2016 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 SUPERFAMILY SSF54373 351 499 1.29E-28 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 SUPERFAMILY SSF51905 95 339 9.46E-56 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 SUPERFAMILY SSF51905 1 60 9.46E-56 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 SUPERFAMILY SSF51905 499 560 9.46E-56 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 Gene3D G3DSA:3.50.50.60 229 337 2.8E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 Gene3D G3DSA:3.50.50.60 2 155 2.8E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 Gene3D G3DSA:3.50.50.60 452 557 2.8E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 PANTHER PTHR11552 104 199 1.1E-43 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 PANTHER PTHR11552 1 88 1.1E-43 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 PANTHER PTHR11552 217 563 1.1E-43 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 PANTHER PTHR11552:SF139 104 199 1.1E-43 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 PANTHER PTHR11552:SF139 1 88 1.1E-43 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 PANTHER PTHR11552:SF139 217 563 1.1E-43 T 21-04-2016 SPH21_RS05015 81af401aee5d37a4131e34db50f0a841 564 Pfam PF05199 GMC oxidoreductase 425 551 1.6E-15 T 21-04-2016 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 SPH21_RS10390 276cf921dcc33256f9d6358881584b62 120 PANTHER PTHR33993 11 120 5.1E-41 T 21-04-2016 SPH21_RS10390 276cf921dcc33256f9d6358881584b62 120 PANTHER PTHR33993:SF1 11 120 5.1E-41 T 21-04-2016 SPH21_RS10390 276cf921dcc33256f9d6358881584b62 120 Gene3D G3DSA:3.10.180.10 15 119 2.4E-21 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS10390 276cf921dcc33256f9d6358881584b62 120 SUPERFAMILY SSF54593 16 119 7.92E-19 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 SUPERFAMILY SSF51735 7 167 9.05E-8 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 Pfam PF02558 Ketopantoate reductase PanE/ApbA 8 133 3.6E-13 T 21-04-2016 IPR013332 Ketopantoate reductase, N-terminal domain GO:0008677|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 SUPERFAMILY SSF48179 180 287 3.74E-18 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 PANTHER PTHR21708 2 285 1.7E-29 T 21-04-2016 SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 Gene3D G3DSA:3.40.50.720 5 187 5.0E-19 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 Gene3D G3DSA:1.10.1040.10 188 306 4.9E-27 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 Pfam PF08546 Ketopantoate reductase PanE/ApbA C terminal 180 286 1.7E-22 T 21-04-2016 IPR013752 Ketopantoate reductase, C-terminal domain GO:0016491|GO:0050661|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS22670 36ced6c35af21ec9b8a516102a681582 320 TIGRFAM TIGR00745 apbA_panE: 2-dehydropantoate 2-reductase 8 287 6.4E-47 T 21-04-2016 IPR003710 Ketopantoate reductase ApbA/PanE GO:0005737|GO:0015940|GO:0016491|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS26080 abc72725fd8ecfa273c4bd5d1f442674 261 Pfam PF10924 Protein of unknown function (DUF2711) 81 194 5.3E-17 T 21-04-2016 IPR024250 Protein of unknown function DUF2711 SPH21_RS26080 abc72725fd8ecfa273c4bd5d1f442674 261 ProDom PD114754 YWBB 84 190 4.0E-9 T 21-04-2016 IPR024250 Protein of unknown function DUF2711 SPH21_RS16845 9c5420272b007a443057e83699471be7 352 PANTHER PTHR32268 11 346 8.8E-112 T 21-04-2016 SPH21_RS16845 9c5420272b007a443057e83699471be7 352 PIRSF PIRSF000443 3 346 2.4E-107 T 21-04-2016 IPR008220 Homoserine acetyltransferase GO:0004414|GO:0005737|GO:0009086 KEGG: 00270+2.3.1.31|MetaCyc: PWY-5344|UniPathway: UPA00051 SPH21_RS16845 9c5420272b007a443057e83699471be7 352 Gene3D G3DSA:3.40.50.1820 20 338 1.1E-38 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16845 9c5420272b007a443057e83699471be7 352 SUPERFAMILY SSF53474 7 338 3.21E-83 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16845 9c5420272b007a443057e83699471be7 352 TIGRFAM TIGR01392 homoserO_Ac_trn: homoserine O-acetyltransferase 10 337 3.2E-105 T 21-04-2016 IPR008220 Homoserine acetyltransferase GO:0004414|GO:0005737|GO:0009086 KEGG: 00270+2.3.1.31|MetaCyc: PWY-5344|UniPathway: UPA00051 SPH21_RS16845 9c5420272b007a443057e83699471be7 352 Pfam PF00561 alpha/beta hydrolase fold 39 322 2.4E-28 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 Gene3D G3DSA:3.40.50.1000 4 157 1.8E-33 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 PANTHER PTHR23133:SF2 187 381 2.7E-134 T 21-04-2016 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19|UniPathway: UPA00031 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 PANTHER PTHR23133:SF2 15 102 2.7E-134 T 21-04-2016 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19|UniPathway: UPA00031 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 Gene3D G3DSA:3.30.230.40 191 278 1.6E-37 T 21-04-2016 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 ProSitePatterns PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 250 263 - T 21-04-2016 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19|UniPathway: UPA00031 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 SUPERFAMILY SSF56784 7 154 2.44E-32 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 TIGRFAM TIGR01662 HAD-SF-IIIA: HAD hydrolase, family IIIA 9 154 7.7E-18 T 21-04-2016 IPR006549 HAD-superfamily hydrolase,subfamily IIIA SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 ProSitePatterns PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 343 355 - T 21-04-2016 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19|UniPathway: UPA00031 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 SUPERFAMILY SSF54211 191 275 1.64E-31 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 Hamap MF_00076 Imidazoleglycerol-phosphate dehydratase [hisB]. 191 381 37.016 T 21-04-2016 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19|UniPathway: UPA00031 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 TIGRFAM TIGR01656 Histidinol-ppas: histidinol-phosphate phosphatase domain 10 153 1.6E-28 T 21-04-2016 IPR006543 Histidinol-phosphate phosphatase GO:0016791 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 Gene3D G3DSA:3.30.230.40 282 381 1.5E-30 T 21-04-2016 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 Pfam PF00475 Imidazoleglycerol-phosphate dehydratase 220 361 2.4E-62 T 21-04-2016 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19|UniPathway: UPA00031 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 TIGRFAM TIGR01261 hisB_Nterm: histidinol-phosphatase 9 156 3.4E-47 T 21-04-2016 IPR005954 Histidinol-phosphatase GO:0000105|GO:0004401|GO:0004424|GO:0005737 KEGG: 00340+4.2.1.19+3.1.3.15|UniPathway: UPA00031|UniPathway: UPA00031 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 SUPERFAMILY SSF54211 277 365 4.17E-30 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 PANTHER PTHR23133 187 381 2.7E-134 T 21-04-2016 SPH21_RS25320 8aa8d15bd14425ab470165bfa910e83f 381 PANTHER PTHR23133 15 102 2.7E-134 T 21-04-2016 SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 Gene3D G3DSA:3.40.50.720 1 232 7.4E-74 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 SUPERFAMILY SSF51735 2 232 1.34E-72 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 1.3E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 1.3E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.3E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 1.3E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 1.3E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PANTHER PTHR24322 12 140 1.1E-62 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PANTHER PTHR24322 156 188 1.1E-62 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 3.6E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 3.6E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 3.6E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 Pfam PF00106 short chain dehydrogenase 8 197 1.1E-58 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8 192 0.0029 T 21-04-2016 SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PANTHER PTHR24322:SF413 12 140 1.1E-62 T 21-04-2016 SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 PANTHER PTHR24322:SF413 156 188 1.1E-62 T 21-04-2016 SPH21_RS23515 bcf1c7d1ba7ce398b3cc1083c0231c55 248 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS22925 7e16fc8c34ff3c83d70d861d10be1609 288 TIGRFAM TIGR02757 TIGR02757: TIGR02757 family protein 20 285 2.7E-60 T 21-04-2016 IPR014127 Conserved hypothetical protein CHP02757 SPH21_RS22925 7e16fc8c34ff3c83d70d861d10be1609 288 Pfam PF09674 Protein of unknown function (DUF2400) 24 285 5.8E-91 T 21-04-2016 IPR014127 Conserved hypothetical protein CHP02757 SPH21_RS01475 68de7329c1201e82047dcc97aca93360 568 Pfam PF10592 AIPR protein 256 508 3.1E-43 T 21-04-2016 IPR018891 Abortive bacteriophage infection, resistance SPH21_RS18360 382c223df23beded4e6b3586d498f2fe 100 SUPERFAMILY SSF47336 13 85 3.93E-7 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS18360 382c223df23beded4e6b3586d498f2fe 100 Gene3D G3DSA:1.10.1200.10 12 72 9.0E-7 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 PANTHER PTHR11601 1 397 1.6E-172 T 21-04-2016 SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 SUPERFAMILY SSF53383 7 380 1.25E-99 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 Gene3D G3DSA:3.90.1150.10 257 377 2.1E-43 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 PANTHER PTHR11601:SF45 1 397 1.6E-172 T 21-04-2016 SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 ProSitePatterns PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 199 218 - T 21-04-2016 IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 PIRSF PIRSF005572 6 387 3.1E-125 T 21-04-2016 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 Gene3D G3DSA:3.40.640.10 21 256 2.3E-84 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS15030 1a5a4b173c8ef091075eb8176349d5a3 398 Pfam PF00266 Aminotransferase class-V 9 371 5.5E-85 T 21-04-2016 IPR000192 Aminotransferase class V domain SPH21_RS22580 423c522114ba0d0e0797730f397d8e04 278 SUPERFAMILY SSF53474 22 252 4.3E-51 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22580 423c522114ba0d0e0797730f397d8e04 278 PANTHER PTHR10992 28 248 2.7E-42 T 21-04-2016 SPH21_RS22580 423c522114ba0d0e0797730f397d8e04 278 Gene3D G3DSA:3.40.50.1820 28 276 2.2E-47 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22580 423c522114ba0d0e0797730f397d8e04 278 Pfam PF00561 alpha/beta hydrolase fold 45 144 3.9E-12 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82693 811 860 2.25E-24 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82693 675 724 2.25E-24 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82714 183 269 8.37E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 Gene3D G3DSA:1.20.1640.10 290 503 7.0E-53 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 Pfam PF00873 AcrB/AcrD/AcrF family 1 1029 3.1E-301 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 Gene3D G3DSA:3.30.70.1430 572 674 4.7E-22 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 Gene3D G3DSA:3.30.2090.10 725 811 3.4E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82714 725 810 5.75E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82693 569 674 5.49E-22 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82866 834 1029 2.35E-39 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 36 54 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 468 491 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 443 466 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 8 32 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 389 413 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 556 573 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 361 382 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 334 357 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PRINTS PR00702 Acriflavin resistance protein family signature 624 638 8.4E-91 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 Gene3D G3DSA:3.30.70.1430 38 133 1.7E-29 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82693 38 130 1.31E-24 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82693 272 325 7.06E-18 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 Gene3D G3DSA:1.10.3850.10 816 1030 2.7E-51 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82693 139 182 7.06E-18 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PANTHER PTHR32063 1 1050 0.0 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 PANTHER PTHR32063:SF9 1 1050 0.0 T 21-04-2016 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 Gene3D G3DSA:3.30.2090.10 182 270 1.1E-22 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 1 1040 0.0 T 21-04-2016 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0005215|GO:0006810|GO:0016021 SPH21_RS12880 aba2c30cb76fcfbba1b7fdfa6dda5ed4 1059 SUPERFAMILY SSF82866 294 496 1.7E-45 T 21-04-2016 SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 252 1.9E-54 T 21-04-2016 SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 88 99 3.5E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 3.5E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 3.5E-8 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 Gene3D G3DSA:3.40.50.720 3 254 3.2E-76 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PANTHER PTHR24322 159 190 1.6E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PANTHER PTHR24322 10 143 1.6E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 SUPERFAMILY SSF51735 4 254 1.52E-74 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 88 99 6.0E-32 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 6.0E-32 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 6.0E-32 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 6.0E-32 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 6.0E-32 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS12340 f49d90f30a3697064caf5f002285e760 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 6.0E-32 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS19505 009388c3db6bf3a26bb9af4a1f1e6385 359 SUPERFAMILY SSF51735 202 219 7.19E-25 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19505 009388c3db6bf3a26bb9af4a1f1e6385 359 SUPERFAMILY SSF51735 25 171 7.19E-25 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19505 009388c3db6bf3a26bb9af4a1f1e6385 359 Gene3D G3DSA:3.40.50.720 22 164 4.1E-25 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19505 009388c3db6bf3a26bb9af4a1f1e6385 359 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 26 143 6.5E-14 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS19505 009388c3db6bf3a26bb9af4a1f1e6385 359 PANTHER PTHR22604 23 359 2.4E-38 T 21-04-2016 SPH21_RS19505 009388c3db6bf3a26bb9af4a1f1e6385 359 Gene3D G3DSA:3.30.360.10 165 359 2.3E-27 T 21-04-2016 SPH21_RS19505 009388c3db6bf3a26bb9af4a1f1e6385 359 SUPERFAMILY SSF55347 155 317 2.62E-18 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PANTHER PTHR32063:SF14 1 1013 0.0 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82714 183 266 2.49E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82866 290 490 5.62E-46 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 438 461 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 10 34 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 542 559 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 385 409 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 38 56 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 357 378 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 463 486 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PRINTS PR00702 Acriflavin resistance protein family signature 330 353 4.6E-63 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82693 40 134 1.46E-24 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 Pfam PF00873 AcrB/AcrD/AcrF family 4 1009 3.2E-288 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 Gene3D G3DSA:3.30.70.1430 561 656 3.6E-11 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 PANTHER PTHR32063 1 1013 0.0 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 Gene3D G3DSA:3.30.2090.10 705 791 1.0E-19 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 Gene3D G3DSA:3.30.2090.10 183 266 1.8E-19 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82714 706 790 2.88E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 Gene3D G3DSA:3.30.70.1430 40 141 1.7E-31 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82866 789 1013 2.09E-47 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 Gene3D G3DSA:1.20.1640.10 286 497 1.4E-52 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82693 138 182 3.66E-19 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82693 268 324 3.66E-19 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 Gene3D G3DSA:1.10.3850.10 798 1012 1.4E-59 T 21-04-2016 SPH21_RS00140 3244c5b3050266366d9b9832483158b1 1038 SUPERFAMILY SSF82693 555 655 3.4E-15 T 21-04-2016 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 Pfam PF00342 Phosphoglucose isomerase 52 541 1.3E-250 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PANTHER PTHR11469:SF11 1 548 0.0 T 21-04-2016 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 Hamap MF_00473 Glucose-6-phosphate isomerase [pgi]. 46 524 42.268 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 Gene3D G3DSA:1.10.1390.10 502 548 3.5E-22 T 21-04-2016 IPR023096 Phosphoglucose isomerase, C-terminal GO:0004347|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 ProSitePatterns PS00765 Phosphoglucose isomerase signature 1. 265 278 - T 21-04-2016 IPR018189 Phosphoglucose isomerase, conserved site GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PANTHER PTHR11469 1 548 0.0 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 Gene3D G3DSA:3.40.50.10490 263 501 1.1E-174 T 21-04-2016 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 Gene3D G3DSA:3.40.50.10490 147 184 1.1E-174 T 21-04-2016 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 Gene3D G3DSA:3.40.50.10490 6 102 1.1E-174 T 21-04-2016 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 ProSitePatterns PS00174 Phosphoglucose isomerase signature 2. 497 514 - T 21-04-2016 IPR018189 Phosphoglucose isomerase, conserved site GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 SUPERFAMILY SSF53697 6 547 1.03E-223 T 21-04-2016 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PRINTS PR00662 Glucose-6-phosphate isomerase signature 261 279 1.4E-56 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PRINTS PR00662 Glucose-6-phosphate isomerase signature 483 497 1.4E-56 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PRINTS PR00662 Glucose-6-phosphate isomerase signature 150 169 1.4E-56 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PRINTS PR00662 Glucose-6-phosphate isomerase signature 497 510 1.4E-56 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PRINTS PR00662 Glucose-6-phosphate isomerase signature 465 483 1.4E-56 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS03360 f905f9c9917a0b217dea03fc802c6317 548 PRINTS PR00662 Glucose-6-phosphate isomerase signature 338 359 1.4E-56 T 21-04-2016 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|UniPathway: UPA00109 SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 SUPERFAMILY SSF51735 112 284 1.74E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 Pfam PF00107 Zinc-binding dehydrogenase 152 271 5.4E-28 T 21-04-2016 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 SMART SM00829 10 320 7.0E-46 T 21-04-2016 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 88 4.1E-10 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 Gene3D G3DSA:3.40.50.720 147 259 3.3E-25 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 Gene3D G3DSA:3.90.180.10 1 146 2.0E-45 T 21-04-2016 IPR011032 GroES-like SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 PANTHER PTHR11695:SF610 15 323 1.4E-135 T 21-04-2016 SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 SUPERFAMILY SSF50129 1 117 6.54E-36 T 21-04-2016 IPR011032 GroES-like SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 SUPERFAMILY SSF50129 292 320 6.54E-36 T 21-04-2016 IPR011032 GroES-like SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 TIGRFAM TIGR02824 quinone_pig3: putative NAD(P)H quinone oxidoreductase, PIG3 family 1 321 1.8E-135 T 21-04-2016 IPR014189 Quinone oxidoreductase PIG3 KEGG: 00231+1.-.-.-|KEGG: 00592+1.-.-.-|KEGG: 00633+1.-.-.-|KEGG: 00780+1.-.-.-|KEGG: 00860+1.-.-.-|KEGG: 00950+1.-.-.-|KEGG: 00981+1.-.-.- SPH21_RS17685 fc427af1399171ff8aa8e5a480f1b829 323 PANTHER PTHR11695 15 323 1.4E-135 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 SUPERFAMILY SSF52540 142 384 6.23E-68 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 SMART SM00448 2 113 1.0E-25 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 166 179 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 409 426 2.5E-5 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 426 445 2.5E-5 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 ProSitePatterns PS00676 Sigma-54 interaction domain ATP-binding region B signature. 228 243 - T 21-04-2016 IPR025943 Sigma-54 interaction domain, ATP-binding site 2 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 Pfam PF02954 Bacterial regulatory protein, Fis family 402 443 5.6E-12 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 Pfam PF00158 Sigma-54 interaction domain 142 308 7.0E-69 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 SUPERFAMILY SSF46689 386 445 2.44E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 Gene3D G3DSA:1.10.8.60 315 388 9.7E-23 T 21-04-2016 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 Gene3D G3DSA:1.10.10.60 389 445 5.1E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 Gene3D G3DSA:3.40.50.300 138 314 3.6E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 Pfam PF00072 Response regulator receiver domain 4 110 4.3E-23 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 PANTHER PTHR32071 4 445 2.2E-185 T 21-04-2016 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 Gene3D G3DSA:3.40.50.2300 2 134 3.1E-30 T 21-04-2016 SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 SMART SM00382 162 305 4.2E-12 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS21140 cb1bbeea6f689252a3f7010bc295b632 445 SUPERFAMILY SSF52172 3 186 1.57E-35 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Pfam PF07715 TonB-dependent Receptor Plug Domain 126 232 1.4E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 208 238 4.9E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 PANTHER PTHR11532 483 547 1.4E-227 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 PANTHER PTHR11532 1 371 1.4E-227 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 PANTHER PTHR11532 570 1021 1.4E-227 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 34 1023 1.4E-257 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 SUPERFAMILY SSF49464 34 116 9.16E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Gene3D G3DSA:2.170.130.10 121 232 3.8E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Pfam PF13715 CarboxypepD_reg-like domain 35 118 4.0E-18 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 PANTHER PTHR11532:SF57 483 547 1.4E-227 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 PANTHER PTHR11532:SF57 1 371 1.4E-227 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 PANTHER PTHR11532:SF57 570 1021 1.4E-227 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Gene3D G3DSA:2.60.40.1120 35 120 9.4E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Pfam PF00593 TonB dependent receptor 617 1021 2.3E-22 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Gene3D G3DSA:2.40.170.20 233 253 8.5E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Gene3D G3DSA:2.40.170.20 918 1023 8.5E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Gene3D G3DSA:2.40.170.20 326 390 8.5E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Gene3D G3DSA:2.40.170.20 423 789 8.5E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 Gene3D G3DSA:2.40.170.20 853 878 8.5E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 SUPERFAMILY SSF56935 844 888 2.97E-102 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 SUPERFAMILY SSF56935 928 1023 2.97E-102 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 SUPERFAMILY SSF56935 114 257 2.97E-102 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 SUPERFAMILY SSF56935 317 405 2.97E-102 T 21-04-2016 SPH21_RS21020 1bdf35a58877f91fd9cf69356dfd5122 1023 SUPERFAMILY SSF56935 443 782 2.97E-102 T 21-04-2016 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 SUPERFAMILY SSF51905 513 573 4.26E-59 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 SUPERFAMILY SSF51905 10 320 4.26E-59 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 Gene3D G3DSA:3.50.50.60 446 459 5.2E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 Gene3D G3DSA:3.50.50.60 504 572 5.2E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 Gene3D G3DSA:3.50.50.60 221 328 5.2E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 Gene3D G3DSA:3.50.50.60 10 151 5.2E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 Pfam PF05199 GMC oxidoreductase 443 564 3.9E-19 T 21-04-2016 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 PANTHER PTHR11552:SF139 14 575 5.0E-69 T 21-04-2016 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 SUPERFAMILY SSF54373 422 514 9.81E-13 T 21-04-2016 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 SUPERFAMILY SSF54373 312 377 9.81E-13 T 21-04-2016 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 PANTHER PTHR11552 14 575 5.0E-69 T 21-04-2016 SPH21_RS22370 56848ce9e6399695408b401a46a3118c 578 Pfam PF00732 GMC oxidoreductase 14 303 1.2E-10 T 21-04-2016 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 SPH21_RS12070 d1390ef81a78e35af922190415323130 301 Pfam PF13712 Glycosyltransferase like family 3 212 1.0E-34 T 21-04-2016 SPH21_RS12070 d1390ef81a78e35af922190415323130 301 Gene3D G3DSA:3.90.550.10 37 210 1.5E-8 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12070 d1390ef81a78e35af922190415323130 301 SUPERFAMILY SSF53448 38 227 1.03E-8 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 Pfam PF00582 Universal stress protein family 1 142 6.9E-16 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 SUPERFAMILY SSF52402 214 275 8.37E-7 T 21-04-2016 SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 Gene3D G3DSA:3.40.50.620 1 143 1.1E-19 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 PRINTS PR01438 Universal stress protein signature 1 19 1.7E-8 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 PRINTS PR01438 Universal stress protein signature 120 142 1.7E-8 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 PRINTS PR01438 Universal stress protein signature 102 114 1.7E-8 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 PANTHER PTHR31964:SF26 1 160 1.4E-17 T 21-04-2016 SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 SUPERFAMILY SSF52402 1 143 2.85E-19 T 21-04-2016 SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 PANTHER PTHR31964 1 160 1.4E-17 T 21-04-2016 SPH21_RS16955 eda3453c2c2751389ec1c26acce24f9f 277 Gene3D G3DSA:3.40.50.620 222 275 3.5E-5 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 Pfam PF13624 SurA N-terminal domain 6 142 2.8E-8 T 21-04-2016 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 SUPERFAMILY SSF109998 27 184 9.03E-24 T 21-04-2016 IPR027304 Trigger factor/SurA domain SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 Pfam PF00639 PPIC-type PPIASE domain 186 270 4.4E-22 T 21-04-2016 IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type GO:0016853 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 PANTHER PTHR10657 7 335 1.2E-47 T 21-04-2016 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 SUPERFAMILY SSF54534 171 274 4.51E-26 T 21-04-2016 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 SUPERFAMILY SSF54534 274 376 1.18E-14 T 21-04-2016 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 Gene3D G3DSA:3.10.50.40 276 417 2.7E-22 T 21-04-2016 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 Gene3D G3DSA:3.10.50.40 171 275 2.5E-29 T 21-04-2016 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 PANTHER PTHR10657:SF11 7 335 1.2E-47 T 21-04-2016 SPH21_RS07250 0d3b57dcef585f1f2d1cc0ab77834af9 464 Pfam PF13616 PPIC-type PPIASE domain 276 341 1.5E-10 T 21-04-2016 SPH21_RS22290 115f1a2982e7330dd03ada8317280f78 417 Pfam PF04542 Sigma-70 region 2 11 78 3.2E-8 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22290 115f1a2982e7330dd03ada8317280f78 417 Gene3D G3DSA:1.10.10.10 133 183 2.4E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22290 115f1a2982e7330dd03ada8317280f78 417 PANTHER PTHR30173:SF15 7 381 3.5E-84 T 21-04-2016 SPH21_RS22290 115f1a2982e7330dd03ada8317280f78 417 PANTHER PTHR30173 7 381 3.5E-84 T 21-04-2016 SPH21_RS22290 115f1a2982e7330dd03ada8317280f78 417 Gene3D G3DSA:1.10.1740.10 9 77 3.9E-9 T 21-04-2016 SPH21_RS22290 115f1a2982e7330dd03ada8317280f78 417 SUPERFAMILY SSF88946 7 79 2.39E-10 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22290 115f1a2982e7330dd03ada8317280f78 417 SUPERFAMILY SSF88659 109 168 7.85E-5 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01490 550cbc1c0080215c45db94362ebdb938 91 Gene3D G3DSA:1.10.10.10 39 82 2.4E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01490 550cbc1c0080215c45db94362ebdb938 91 Pfam PF12728 Helix-turn-helix domain 38 86 6.4E-11 T 21-04-2016 SPH21_RS01490 550cbc1c0080215c45db94362ebdb938 91 PANTHER PTHR34585 3 85 6.3E-15 T 21-04-2016 SPH21_RS01490 550cbc1c0080215c45db94362ebdb938 91 SUPERFAMILY SSF46955 38 84 6.1E-8 T 21-04-2016 IPR009061 Putative DNA-binding domain SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 308 338 1.4E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Gene3D G3DSA:2.60.40.1120 136 220 1.3E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Gene3D G3DSA:2.40.170.20 334 352 3.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Gene3D G3DSA:2.40.170.20 413 875 3.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Gene3D G3DSA:2.40.170.20 998 1101 3.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Gene3D G3DSA:2.40.170.20 935 960 3.5E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 SUPERFAMILY SSF49464 135 229 2.35E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Pfam PF07715 TonB-dependent Receptor Plug Domain 225 332 9.2E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 PANTHER PTHR11532 132 523 1.3E-252 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 PANTHER PTHR11532 599 1099 1.3E-252 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 PANTHER PTHR11532:SF57 132 523 1.3E-252 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 PANTHER PTHR11532:SF57 599 1099 1.3E-252 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 SUPERFAMILY SSF56935 926 970 2.49E-96 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 SUPERFAMILY SSF56935 531 866 2.49E-96 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 SUPERFAMILY SSF56935 1007 1101 2.49E-96 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 SUPERFAMILY SSF56935 211 356 2.49E-96 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 SUPERFAMILY SSF56935 404 492 2.49E-96 T 21-04-2016 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 135 1101 1.0E-271 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Gene3D G3DSA:2.170.130.10 221 333 1.8E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06285 62e727280a13841de8f27dd941926d37 1101 Pfam PF13715 CarboxypepD_reg-like domain 136 217 2.6E-16 T 21-04-2016 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SUPERFAMILY SSF55785 28 136 2.09E-29 T 21-04-2016 IPR000014 PAS domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SMART SM00091 168 234 1.5 T 21-04-2016 IPR000014 PAS domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SMART SM00091 21 90 3.5E-7 T 21-04-2016 IPR000014 PAS domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SUPERFAMILY SSF55874 346 512 1.27E-40 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Pfam PF13426 PAS domain 33 136 3.7E-24 T 21-04-2016 IPR000014 PAS domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SUPERFAMILY SSF47384 277 357 5.89E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 PANTHER PTHR24423 13 512 1.4E-94 T 21-04-2016 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Pfam PF13188 PAS domain 170 211 0.0081 T 21-04-2016 IPR000014 PAS domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Gene3D G3DSA:3.30.450.20 162 280 3.8E-7 T 21-04-2016 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 PRINTS PR00344 Bacterial sensor protein C-terminal signature 470 488 2.1E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 PRINTS PR00344 Bacterial sensor protein C-terminal signature 436 450 2.1E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 PRINTS PR00344 Bacterial sensor protein C-terminal signature 454 464 2.1E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 PRINTS PR00344 Bacterial sensor protein C-terminal signature 494 507 2.1E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SMART SM00387 399 510 5.3E-32 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Gene3D G3DSA:3.30.450.20 32 137 7.8E-38 T 21-04-2016 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Gene3D G3DSA:1.10.287.130 281 352 2.1E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SMART SM00388 288 356 2.3E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 25 145 1.3E-21 T 21-04-2016 IPR000014 PAS domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Gene3D G3DSA:3.30.565.10 357 515 3.4E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 399 509 1.2E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SMART SM00086 96 138 1.7E-11 T 21-04-2016 IPR001610 PAC motif SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 SUPERFAMILY SSF55785 161 244 3.49E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS25245 04aa5b4f4003f0de5d68848ea2fc379a 520 Pfam PF00512 His Kinase A (phospho-acceptor) domain 289 356 2.3E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10870 c13de1e010a5e2023f62a44d1c8e40dc 101 PANTHER PTHR11434 3 100 1.1E-25 T 21-04-2016 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SPH21_RS10870 c13de1e010a5e2023f62a44d1c8e40dc 101 PANTHER PTHR11434:SF0 3 100 1.1E-25 T 21-04-2016 SPH21_RS10870 c13de1e010a5e2023f62a44d1c8e40dc 101 Hamap MF_01456 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic [ndhE]. 2 101 17.537 T 21-04-2016 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SPH21_RS10870 c13de1e010a5e2023f62a44d1c8e40dc 101 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 7 96 2.0E-21 T 21-04-2016 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 PANTHER PTHR11019 26 300 8.3E-30 T 21-04-2016 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 Gene3D G3DSA:1.10.10.60 247 293 2.8E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 Gene3D G3DSA:2.60.120.280 45 176 8.3E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 SUPERFAMILY SSF46689 247 293 1.48E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 Pfam PF12833 Helix-turn-helix domain 215 293 1.4E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 Gene3D G3DSA:1.10.10.60 188 237 1.1E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 SUPERFAMILY SSF51215 43 172 3.14E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 PANTHER PTHR11019:SF80 26 300 8.3E-30 T 21-04-2016 SPH21_RS26135 574b64d226a38b882eb467ba0856106e 301 SMART SM00342 209 292 1.3E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS07505 22a1f2b9fe005a40c91789525a062728 227 Gene3D G3DSA:3.60.15.10 1 227 5.3E-50 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS07505 22a1f2b9fe005a40c91789525a062728 227 Pfam PF13483 Beta-lactamase superfamily domain 4 191 7.6E-21 T 21-04-2016 SPH21_RS07505 22a1f2b9fe005a40c91789525a062728 227 SUPERFAMILY SSF56281 1 219 1.76E-31 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS07505 22a1f2b9fe005a40c91789525a062728 227 SMART SM00849 7 191 4.5E-9 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS07505 22a1f2b9fe005a40c91789525a062728 227 PANTHER PTHR15032 1 227 4.1E-45 T 21-04-2016 SPH21_RS07505 22a1f2b9fe005a40c91789525a062728 227 PANTHER PTHR15032:SF13 1 227 4.1E-45 T 21-04-2016 SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 Pfam PF08281 Sigma-70, region 4 130 182 5.8E-9 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 SUPERFAMILY SSF88946 11 119 2.2E-15 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 Gene3D G3DSA:1.10.10.10 129 188 3.3E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 33 186 1.5E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 PANTHER PTHR30173 5 191 8.9E-26 T 21-04-2016 SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 Gene3D G3DSA:1.10.1740.10 11 124 3.1E-16 T 21-04-2016 SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 SUPERFAMILY SSF88659 107 189 1.05E-11 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03190 744eb5a4cf118f1c941967b421e748ea 193 Pfam PF04542 Sigma-70 region 2 35 101 1.6E-9 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 Gene3D G3DSA:3.40.47.10 3 125 6.2E-61 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 Gene3D G3DSA:3.40.47.10 184 272 6.2E-61 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 Gene3D G3DSA:3.40.47.10 274 389 4.2E-62 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 Gene3D G3DSA:3.40.47.10 142 183 4.2E-62 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 ProSitePatterns PS00737 Thiolases signature 2. 336 352 - T 21-04-2016 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 Pfam PF00108 Thiolase, N-terminal domain 4 259 2.2E-63 T 21-04-2016 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 ProSitePatterns PS00098 Thiolases acyl-enzyme intermediate signature. 86 104 - T 21-04-2016 IPR020615 Thiolase, acyl-enzyme intermediate active site GO:0008152|GO:0016747 Reactome: REACT_22258 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 PIRSF PIRSF000429 1 390 8.1E-122 T 21-04-2016 IPR002155 Thiolase GO:0008152|GO:0016747 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 ProSitePatterns PS00099 Thiolases active site. 371 384 - T 21-04-2016 IPR020610 Thiolase, active site GO:0008152|GO:0016747 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 SUPERFAMILY SSF53901 268 389 1.39E-42 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 SUPERFAMILY SSF53901 2 264 2.47E-69 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 5 388 4.1E-135 T 21-04-2016 IPR002155 Thiolase GO:0008152|GO:0016747 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 PANTHER PTHR18919:SF87 1 390 3.1E-173 T 21-04-2016 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 PANTHER PTHR18919 1 390 3.1E-173 T 21-04-2016 SPH21_RS00100 a4279cf0f9a19e0fb0ce469c454b9edd 390 Pfam PF02803 Thiolase, C-terminal domain 268 388 4.8E-47 T 21-04-2016 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Pfam PF07715 TonB-dependent Receptor Plug Domain 216 343 2.4E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Pfam PF13715 CarboxypepD_reg-like domain 127 207 8.0E-15 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 125 1129 5.2E-202 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532:SF51 535 585 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532:SF51 79 290 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532:SF51 680 1127 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532:SF51 310 506 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532:SF51 625 653 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Pfam PF07660 Secretin and TonB N terminus short domain 67 116 4.3E-8 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Gene3D G3DSA:2.60.40.1120 127 208 2.1E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 319 349 2.8E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 SUPERFAMILY SSF49464 125 205 3.66E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532 535 585 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532 79 290 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532 680 1127 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532 310 506 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 PANTHER PTHR11532 625 653 9.2E-199 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 SMART SM00965 66 117 2.9E-4 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Gene3D G3DSA:2.170.130.10 209 343 7.0E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 SUPERFAMILY SSF56935 558 890 9.89E-87 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 SUPERFAMILY SSF56935 1035 1124 9.89E-87 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 SUPERFAMILY SSF56935 431 519 9.89E-87 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 SUPERFAMILY SSF56935 954 989 9.89E-87 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 SUPERFAMILY SSF56935 204 366 9.89E-87 T 21-04-2016 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Gene3D G3DSA:2.40.170.20 1026 1125 3.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Gene3D G3DSA:2.40.170.20 954 979 3.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Gene3D G3DSA:2.40.170.20 553 919 3.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Gene3D G3DSA:2.40.170.20 344 364 3.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14715 fa3973cc9f34124a8f1c7e3623beeba7 1129 Gene3D G3DSA:2.40.170.20 440 515 3.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 SUPERFAMILY SSF52096 25 277 3.09E-82 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 TIGRFAM TIGR00515 accD: acetyl-CoA carboxylase, carboxyl transferase, beta subunit 2 277 1.7E-111 T 21-04-2016 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 229 240 9.5E-38 T 21-04-2016 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 200 217 9.5E-38 T 21-04-2016 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 129 143 9.5E-38 T 21-04-2016 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 163 181 9.5E-38 T 21-04-2016 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 251 260 9.5E-38 T 21-04-2016 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 PANTHER PTHR22855 1 277 1.1E-136 T 21-04-2016 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 Gene3D G3DSA:3.90.226.10 18 277 4.5E-73 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 Hamap MF_01395 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic [accD]. 1 278 37.264 T 21-04-2016 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 PANTHER PTHR22855:SF17 1 277 1.1E-136 T 21-04-2016 SPH21_RS19825 b24994c2b8fb7a9ab34eefb5702943c5 280 Pfam PF01039 Carboxyl transferase domain 96 239 6.4E-19 T 21-04-2016 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS15510 087979a1801ad65efcd9be7c889ff172 441 SUPERFAMILY SSF53850 52 170 1.74E-15 T 21-04-2016 SPH21_RS15510 087979a1801ad65efcd9be7c889ff172 441 PANTHER PTHR41312 303 441 1.4E-31 T 21-04-2016 SPH21_RS15510 087979a1801ad65efcd9be7c889ff172 441 PANTHER PTHR41312 2 278 1.4E-31 T 21-04-2016 SPH21_RS15510 087979a1801ad65efcd9be7c889ff172 441 Gene3D G3DSA:3.40.190.10 47 145 3.8E-12 T 21-04-2016 SPH21_RS15510 087979a1801ad65efcd9be7c889ff172 441 Pfam PF12698 ABC-2 family transporter protein 19 414 5.1E-57 T 21-04-2016 SPH21_RS25460 28310a5ab44b7ad68342cf5942eb0feb 484 SUPERFAMILY SSF48452 20 484 9.36E-83 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25460 28310a5ab44b7ad68342cf5942eb0feb 484 Pfam PF07980 SusD family 340 484 1.3E-19 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS25460 28310a5ab44b7ad68342cf5942eb0feb 484 Pfam PF14322 Starch-binding associating with outer membrane 71 219 6.4E-16 T 21-04-2016 SPH21_RS25460 28310a5ab44b7ad68342cf5942eb0feb 484 Gene3D G3DSA:1.25.40.10 200 431 6.6E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 Gene3D G3DSA:3.40.720.10 24 403 1.2E-109 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 Pfam PF00884 Sulfatase 26 367 9.3E-72 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 Gene3D G3DSA:3.30.1120.10 404 469 5.6E-16 T 21-04-2016 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 PANTHER PTHR10342 258 460 2.0E-142 T 21-04-2016 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 PANTHER PTHR10342 4 241 2.0E-142 T 21-04-2016 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 PANTHER PTHR10342:SF199 258 460 2.0E-142 T 21-04-2016 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 PANTHER PTHR10342:SF199 4 241 2.0E-142 T 21-04-2016 SPH21_RS23480 05d805117eb860c8377bb10a3247c0f7 471 SUPERFAMILY SSF53649 24 462 5.23E-126 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 SUPERFAMILY SSF56712 1 597 2.35E-159 T 21-04-2016 IPR023405 DNA topoisomerase, type IA, core domain SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 SMART SM00436 131 223 5.3E-28 T 21-04-2016 IPR003601 DNA topoisomerase, type IA, domain 2 GO:0003677|GO:0003916|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 Gene3D G3DSA:1.10.290.10 284 407 3.1E-35 T 21-04-2016 IPR013826 DNA topoisomerase, type IA, central region, subdomain 3 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 SMART SM00437 273 550 9.0E-79 T 21-04-2016 IPR003602 DNA topoisomerase, type IA, DNA-binding domain GO:0003677|GO:0003916|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 Gene3D G3DSA:3.40.50.140 1 158 2.9E-44 T 21-04-2016 IPR006171 Toprim domain SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 Pfam PF01131 DNA topoisomerase 158 578 3.5E-117 T 21-04-2016 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 315 324 6.7E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 105 118 6.7E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 193 211 6.7E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 513 527 6.7E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 394 410 6.7E-23 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 SMART SM00493 1 131 8.7E-17 T 21-04-2016 IPR006171 Toprim domain SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 TIGRFAM TIGR01056 topB: DNA topoisomerase III 1 597 4.0E-161 T 21-04-2016 IPR005738 DNA topoisomerase III GO:0003677|GO:0003916|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PANTHER PTHR11390 1 496 5.4E-153 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PANTHER PTHR11390 513 600 5.4E-153 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 Pfam PF01751 Toprim domain 3 138 1.0E-13 T 21-04-2016 IPR006171 Toprim domain SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 Gene3D G3DSA:1.10.460.10 161 217 1.5E-48 T 21-04-2016 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 Gene3D G3DSA:1.10.460.10 467 598 1.5E-48 T 21-04-2016 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PANTHER PTHR11390:SF21 1 496 5.4E-153 T 21-04-2016 SPH21_RS18290 daf75abd53498e64d4483fdf5fcda97f 613 PANTHER PTHR11390:SF21 513 600 5.4E-153 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PRINTS PR00315 GTP-binding elongation factor signature 73 83 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PRINTS PR00315 GTP-binding elongation factor signature 125 134 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PRINTS PR00315 GTP-binding elongation factor signature 6 19 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PRINTS PR00315 GTP-binding elongation factor signature 89 100 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PRINTS PR00315 GTP-binding elongation factor signature 49 57 3.7E-14 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Gene3D G3DSA:2.40.30.10 192 289 1.9E-21 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Pfam PF00679 Elongation factor G C-terminus 399 484 4.1E-19 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 SUPERFAMILY SSF54980 291 369 5.04E-19 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 SUPERFAMILY SSF54980 398 493 1.63E-22 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Gene3D G3DSA:3.40.50.300 2 191 8.4E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 5 172 2.8E-21 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Hamap MF_00071 Elongation factor 4 [lepA]. 1 595 286.371 T 21-04-2016 IPR006297 Elongation factor 4 GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Pfam PF03144 Elongation factor Tu domain 2 206 274 1.0E-7 T 21-04-2016 IPR004161 Translation elongation factor EFTu/EF1A, domain 2 GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Gene3D G3DSA:3.30.70.240 400 489 1.8E-18 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Gene3D G3DSA:3.30.70.870 290 367 6.4E-26 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 TIGRFAM TIGR01393 lepA: elongation factor 4 2 595 5.6E-299 T 21-04-2016 IPR006297 Elongation factor 4 GO:0005525 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PANTHER PTHR23115:SF175 396 595 1.1E-275 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PANTHER PTHR23115:SF175 2 372 1.1E-275 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Pfam PF06421 GTP-binding protein LepA C-terminus 487 593 1.7E-51 T 21-04-2016 IPR013842 GTP-binding protein LepA, C-terminal SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 Pfam PF00009 Elongation factor Tu GTP binding domain 2 180 2.5E-55 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PANTHER PTHR23115 396 595 1.1E-275 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 PANTHER PTHR23115 2 372 1.1E-275 T 21-04-2016 SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 SUPERFAMILY SSF52540 2 206 3.1E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17175 02abf537d869c5a142d367d5338c4e39 595 SUPERFAMILY SSF50447 181 286 2.25E-21 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 Hamap MF_01024 Histidinol dehydrogenase [hisD]. 5 427 39.098 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 230 251 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 320 345 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 199 224 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 252 271 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 361 379 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 33 57 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 169 195 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PRINTS PR00083 Histidinol dehydrogenase signature 134 160 1.8E-93 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 Gene3D G3DSA:3.40.50.1980 28 240 5.2E-76 T 21-04-2016 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PANTHER PTHR21256 1 432 2.2E-223 T 21-04-2016 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 SUPERFAMILY SSF53720 27 427 2.16E-72 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 ProSitePatterns PS00611 Histidinol dehydrogenase signature. 230 262 - T 21-04-2016 IPR001692 Histidinol dehydrogenase, conserved site GO:0000105|GO:0004399|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 Pfam PF00815 Histidinol dehydrogenase 22 427 7.1E-168 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 TIGRFAM TIGR00069 hisD: histidinol dehydrogenase 33 426 1.0E-159 T 21-04-2016 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PANTHER PTHR21256:SF2 1 432 2.2E-223 T 21-04-2016 SPH21_RS25310 5c01926106c1ad5a9451ace01138c80a 432 PIRSF PIRSF000099 1 430 1.1E-164 T 21-04-2016 IPR022695 Histidinol dehydrogenase, monofunctional GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23|UniPathway: UPA00031 SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 PIRSF PIRSF028757 23 340 2.3E-69 T 21-04-2016 IPR003507 Peptidase family S66 SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 SUPERFAMILY SSF141986 193 332 6.67E-28 T 21-04-2016 IPR027461 LD-carboxypeptidase A, C-terminal domain SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 SUPERFAMILY SSF52317 24 189 3.07E-41 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 Gene3D G3DSA:3.40.50.10740 26 189 5.1E-45 T 21-04-2016 IPR027478 Murein tetrapeptide carboxypeptidase, N-terminal domain SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 Gene3D G3DSA:3.50.30.60 208 332 1.1E-27 T 21-04-2016 IPR027461 LD-carboxypeptidase A, C-terminal domain SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 PANTHER PTHR30237:SF5 23 332 5.6E-118 T 21-04-2016 SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 Pfam PF02016 LD-carboxypeptidase 35 330 7.9E-69 T 21-04-2016 IPR003507 Peptidase family S66 SPH21_RS10740 1df50611b56e609f49083d5337f00f60 344 PANTHER PTHR30237 23 332 5.6E-118 T 21-04-2016 SPH21_RS17135 156e1c407f11d673b9bf76696e8b20c9 410 PANTHER PTHR35793 3 410 2.1E-226 T 21-04-2016 SPH21_RS17135 156e1c407f11d673b9bf76696e8b20c9 410 PANTHER PTHR35793:SF2 3 410 2.1E-226 T 21-04-2016 SPH21_RS17135 156e1c407f11d673b9bf76696e8b20c9 410 Pfam PF07670 Nucleoside recognition 51 166 6.6E-10 T 21-04-2016 IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain Reactome: REACT_15518|Reactome: REACT_1698 SPH21_RS17135 156e1c407f11d673b9bf76696e8b20c9 410 PIRSF PIRSF036542 2 410 1.5E-189 T 21-04-2016 IPR011415 Predicted bifunctional spore maturation protein, fused SpmA/SpmB SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 Gene3D G3DSA:3.40.50.300 439 598 3.2E-8 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 Gene3D G3DSA:3.40.50.300 354 438 1.5E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 Gene3D G3DSA:3.40.50.300 168 285 1.5E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 Pfam PF13086 AAA domain 175 396 9.7E-56 T 21-04-2016 SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 SUPERFAMILY SSF52540 173 618 4.26E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 Pfam PF13087 AAA domain 405 599 1.9E-55 T 21-04-2016 SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 TIGRFAM TIGR00376 TIGR00376: putative DNA helicase 20 620 1.2E-124 T 21-04-2016 IPR004483 Helicase SMUBP-2/Hcs1-like GO:0003677|GO:0005524 SPH21_RS13515 49ab2ca1d38db2420047d6147bf66546 630 PANTHER PTHR10887 2 624 1.5E-158 T 21-04-2016 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 SUPERFAMILY SSF102886 5 298 2.62E-116 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PANTHER PTHR10755 13 299 6.7E-153 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 ProSitePatterns PS01021 Coproporphyrinogen III oxidase signature. 158 182 - T 21-04-2016 IPR018375 Coproporphyrinogen III oxidase, conserved site GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PIRSF PIRSF000166 2 299 1.1E-119 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PRINTS PR00073 Coprogen oxidase signature 154 183 2.3E-80 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PRINTS PR00073 Coprogen oxidase signature 117 139 2.3E-80 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PRINTS PR00073 Coprogen oxidase signature 29 45 2.3E-80 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PRINTS PR00073 Coprogen oxidase signature 86 110 2.3E-80 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PRINTS PR00073 Coprogen oxidase signature 258 284 2.3E-80 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PRINTS PR00073 Coprogen oxidase signature 46 67 2.3E-80 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 PRINTS PR00073 Coprogen oxidase signature 230 257 2.3E-80 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 Gene3D G3DSA:3.40.1500.10 5 298 8.5E-122 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS16730 79f9556bd249d42b8d22f6084f73ae3b 301 Pfam PF01218 Coproporphyrinogen III oxidase 10 298 2.0E-125 T 21-04-2016 IPR001260 Coproporphyrinogen III oxidase, aerobic GO:0004109|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.3|MetaCyc: PWY-5531|MetaCyc: PWY-7159|UniPathway: UPA00251 SPH21_RS06540 f673a2c5a372aeedd645d0598a19c793 216 PANTHER PTHR33594:SF1 5 214 5.8E-85 T 21-04-2016 SPH21_RS06540 f673a2c5a372aeedd645d0598a19c793 216 SUPERFAMILY SSF109604 5 215 2.54E-75 T 21-04-2016 SPH21_RS06540 f673a2c5a372aeedd645d0598a19c793 216 SMART SM00471 21 137 1.1E-8 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS06540 f673a2c5a372aeedd645d0598a19c793 216 Pfam PF01966 HD domain 28 127 3.1E-9 T 21-04-2016 IPR006674 HD domain SPH21_RS06540 f673a2c5a372aeedd645d0598a19c793 216 PANTHER PTHR33594 5 214 5.8E-85 T 21-04-2016 SPH21_RS06540 f673a2c5a372aeedd645d0598a19c793 216 Gene3D G3DSA:1.10.3210.10 5 141 6.6E-52 T 21-04-2016 IPR006674 HD domain SPH21_RS06540 f673a2c5a372aeedd645d0598a19c793 216 Gene3D G3DSA:1.10.3210.10 184 214 6.6E-52 T 21-04-2016 IPR006674 HD domain SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 PANTHER PTHR30031 21 532 2.2E-282 T 21-04-2016 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 Gene3D G3DSA:3.40.449.10 21 212 1.3E-69 T 21-04-2016 IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: REACT_474|UniPathway: UPA00138 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 PANTHER PTHR30031:SF0 21 532 2.2E-282 T 21-04-2016 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 Hamap MF_00453 Phosphoenolpyruvate carboxykinase [ATP] [pckA]. 15 531 51.814 T 21-04-2016 IPR001272 Phosphoenolpyruvate carboxykinase, ATP-utilising GO:0004612|GO:0005524|GO:0006094 KEGG: 00010+4.1.1.49|KEGG: 00020+4.1.1.49|KEGG: 00620+4.1.1.49|KEGG: 00710+4.1.1.49|MetaCyc: PWY-561|MetaCyc: PWY-7117|UniPathway: UPA00138 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 PIRSF PIRSF006294 5 531 2.2E-222 T 21-04-2016 IPR001272 Phosphoenolpyruvate carboxykinase, ATP-utilising GO:0004612|GO:0005524|GO:0006094 KEGG: 00010+4.1.1.49|KEGG: 00020+4.1.1.49|KEGG: 00620+4.1.1.49|KEGG: 00710+4.1.1.49|MetaCyc: PWY-561|MetaCyc: PWY-7117|UniPathway: UPA00138 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 SUPERFAMILY SSF53795 215 531 3.43E-127 T 21-04-2016 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 TIGRFAM TIGR00224 pckA: phosphoenolpyruvate carboxykinase (ATP) 21 531 3.5E-207 T 21-04-2016 IPR001272 Phosphoenolpyruvate carboxykinase, ATP-utilising GO:0004612|GO:0005524|GO:0006094 KEGG: 00010+4.1.1.49|KEGG: 00020+4.1.1.49|KEGG: 00620+4.1.1.49|KEGG: 00710+4.1.1.49|MetaCyc: PWY-561|MetaCyc: PWY-7117|UniPathway: UPA00138 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 SUPERFAMILY SSF68923 9 212 4.36E-71 T 21-04-2016 IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: REACT_474|UniPathway: UPA00138 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 Gene3D G3DSA:3.90.228.20 215 278 8.6E-119 T 21-04-2016 IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: REACT_474|UniPathway: UPA00138 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 Gene3D G3DSA:3.90.228.20 339 530 8.6E-119 T 21-04-2016 IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: REACT_474|UniPathway: UPA00138 SPH21_RS15015 c8417636a04e017f9a814e6274617089 536 Pfam PF01293 Phosphoenolpyruvate carboxykinase 21 483 4.8E-213 T 21-04-2016 IPR001272 Phosphoenolpyruvate carboxykinase, ATP-utilising GO:0004612|GO:0005524|GO:0006094 KEGG: 00010+4.1.1.49|KEGG: 00020+4.1.1.49|KEGG: 00620+4.1.1.49|KEGG: 00710+4.1.1.49|MetaCyc: PWY-561|MetaCyc: PWY-7117|UniPathway: UPA00138 SPH21_RS08770 2af64267e22ef2f439d1874d59036269 496 Pfam PF14322 Starch-binding associating with outer membrane 55 235 8.6E-22 T 21-04-2016 SPH21_RS08770 2af64267e22ef2f439d1874d59036269 496 Pfam PF07980 SusD family 352 496 1.3E-18 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS08770 2af64267e22ef2f439d1874d59036269 496 SUPERFAMILY SSF48452 17 442 1.1E-81 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08770 2af64267e22ef2f439d1874d59036269 496 SUPERFAMILY SSF48452 470 496 1.1E-81 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08770 2af64267e22ef2f439d1874d59036269 496 Gene3D G3DSA:1.25.40.10 215 415 3.5E-25 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS17105 ec5dcbfc7bbe1022830210c57e32a7ce 124 SUPERFAMILY SSF47413 1 64 1.16E-6 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS17105 ec5dcbfc7bbe1022830210c57e32a7ce 124 Gene3D G3DSA:1.10.260.40 3 95 3.5E-7 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 292 307 1.5E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 307 323 1.5E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 Gene3D G3DSA:1.10.10.60 225 277 3.5E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 277 319 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 PANTHER PTHR11019 186 323 7.8E-31 T 21-04-2016 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 Pfam PF12833 Helix-turn-helix domain 246 323 8.5E-25 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 PANTHER PTHR11019:SF61 186 323 7.8E-31 T 21-04-2016 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 SUPERFAMILY SSF46689 276 323 1.08E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 Gene3D G3DSA:1.10.10.60 278 323 2.2E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 SMART SM00342 240 323 4.3E-30 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS18445 6d32bdacecac76f0fc0d15b764484359 323 SUPERFAMILY SSF46689 226 274 1.43E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24695 d2c8b2425375b490849801c1e9b99b1f 141 PANTHER PTHR33990:SF2 3 140 2.6E-61 T 21-04-2016 SPH21_RS24695 d2c8b2425375b490849801c1e9b99b1f 141 SUPERFAMILY SSF54593 4 140 6.57E-43 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS24695 d2c8b2425375b490849801c1e9b99b1f 141 PIRSF PIRSF021700 1 141 5.5E-54 T 21-04-2016 IPR009725 Predicted 3-demethylubiquinone-9 3-methyltransferase SPH21_RS24695 d2c8b2425375b490849801c1e9b99b1f 141 PANTHER PTHR33990 3 140 2.6E-61 T 21-04-2016 SPH21_RS24695 d2c8b2425375b490849801c1e9b99b1f 141 Pfam PF06983 3-demethylubiquinone-9 3-methyltransferase 4 106 9.1E-42 T 21-04-2016 IPR028973 3-demethylubiquinone-9 3-methyltransferase SPH21_RS24695 d2c8b2425375b490849801c1e9b99b1f 141 Gene3D G3DSA:3.10.180.10 2 118 4.6E-42 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS12455 a7c0fab0cfd50645d571a3c840440f46 145 ProSitePatterns PS01332 Rrf2-type HTH domain signature. 51 69 - T 21-04-2016 IPR030489 Transcription regulator Rrf2-type, conserved site SPH21_RS12455 a7c0fab0cfd50645d571a3c840440f46 145 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 4 130 2.7E-24 T 21-04-2016 IPR000944 Transcription regulator Rrf2-type SPH21_RS12455 a7c0fab0cfd50645d571a3c840440f46 145 SUPERFAMILY SSF46785 5 133 4.86E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12455 a7c0fab0cfd50645d571a3c840440f46 145 Gene3D G3DSA:1.10.10.10 5 136 3.8E-25 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12455 a7c0fab0cfd50645d571a3c840440f46 145 Pfam PF02082 Transcriptional regulator 4 84 8.4E-17 T 21-04-2016 IPR000944 Transcription regulator Rrf2-type SPH21_RS12455 a7c0fab0cfd50645d571a3c840440f46 145 PANTHER PTHR33221 3 129 2.4E-25 T 21-04-2016 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 SUPERFAMILY SSF47757 3 74 1.57E-6 T 21-04-2016 IPR022641 Chemotaxis receptor methyltransferase CheR, N-terminal SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 Pfam PF03705 CheR methyltransferase, all-alpha domain 11 61 3.5E-6 T 21-04-2016 IPR022641 Chemotaxis receptor methyltransferase CheR, N-terminal SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 SUPERFAMILY SSF53335 75 254 3.76E-40 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 PANTHER PTHR24422:SF8 7 277 5.1E-92 T 21-04-2016 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 Gene3D G3DSA:3.40.50.150 74 271 3.7E-56 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 PANTHER PTHR24422 7 277 5.1E-92 T 21-04-2016 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 SMART SM00138 9 272 5.5E-25 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 PRINTS PR00996 Glutamate methyltransferase family signature 136 152 5.4E-28 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 PRINTS PR00996 Glutamate methyltransferase family signature 68 80 5.4E-28 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 PRINTS PR00996 Glutamate methyltransferase family signature 229 252 5.4E-28 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 PRINTS PR00996 Glutamate methyltransferase family signature 210 224 5.4E-28 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 PRINTS PR00996 Glutamate methyltransferase family signature 104 124 5.4E-28 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS05485 a50bc361c977eca03af9ae086c88c939 278 Pfam PF01739 CheR methyltransferase, SAM binding domain 75 265 1.0E-37 T 21-04-2016 IPR022642 MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal SPH21_RS16500 23f433d3b380ff7044a5466795a45b7c 366 PANTHER PTHR13693 23 365 3.4E-123 T 21-04-2016 SPH21_RS16500 23f433d3b380ff7044a5466795a45b7c 366 Gene3D G3DSA:3.90.1150.10 252 361 3.3E-12 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS16500 23f433d3b380ff7044a5466795a45b7c 366 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216 225 - T 21-04-2016 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SPH21_RS16500 23f433d3b380ff7044a5466795a45b7c 366 Gene3D G3DSA:3.40.640.10 54 251 8.2E-76 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS16500 23f433d3b380ff7044a5466795a45b7c 366 PANTHER PTHR13693:SF53 23 365 3.4E-123 T 21-04-2016 SPH21_RS16500 23f433d3b380ff7044a5466795a45b7c 366 SUPERFAMILY SSF53383 11 364 5.05E-76 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS16500 23f433d3b380ff7044a5466795a45b7c 366 Pfam PF00155 Aminotransferase class I and II 23 355 1.5E-38 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS07930 0c1bf1bf1bab765c33fa829fdd623b17 180 PANTHER PTHR10286:SF19 1 177 4.4E-98 T 21-04-2016 SPH21_RS07930 0c1bf1bf1bab765c33fa829fdd623b17 180 PANTHER PTHR10286 1 177 4.4E-98 T 21-04-2016 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1|Reactome: REACT_21259|Reactome: REACT_71 SPH21_RS07930 0c1bf1bf1bab765c33fa829fdd623b17 180 SUPERFAMILY SSF50324 4 178 4.45E-70 T 21-04-2016 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1|Reactome: REACT_21259|Reactome: REACT_71 SPH21_RS07930 0c1bf1bf1bab765c33fa829fdd623b17 180 Hamap MF_00209 Inorganic pyrophosphatase [ppa]. 18 174 31.696 T 21-04-2016 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1|Reactome: REACT_21259|Reactome: REACT_71 SPH21_RS07930 0c1bf1bf1bab765c33fa829fdd623b17 180 Pfam PF00719 Inorganic pyrophosphatase 22 173 3.1E-57 T 21-04-2016 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1|Reactome: REACT_21259|Reactome: REACT_71 SPH21_RS07930 0c1bf1bf1bab765c33fa829fdd623b17 180 Gene3D G3DSA:3.90.80.10 3 177 5.3E-64 T 21-04-2016 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1|Reactome: REACT_21259|Reactome: REACT_71 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Pfam PF08447 PAS fold 1020 1106 8.9E-18 T 21-04-2016 IPR013655 PAS fold-3 GO:0005515 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 995 1119 4.0E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Gene3D G3DSA:3.30.450.20 987 1126 3.8E-26 T 21-04-2016 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Pfam PF01739 CheR methyltransferase, SAM binding domain 276 468 1.1E-50 T 21-04-2016 IPR022642 MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PRINTS PR00996 Glutamate methyltransferase family signature 345 361 6.6E-25 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PRINTS PR00996 Glutamate methyltransferase family signature 411 425 6.6E-25 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PRINTS PR00996 Glutamate methyltransferase family signature 269 281 6.6E-25 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PRINTS PR00996 Glutamate methyltransferase family signature 430 453 6.6E-25 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PRINTS PR00996 Glutamate methyltransferase family signature 309 329 6.6E-25 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PRINTS PR00996 Glutamate methyltransferase family signature 232 245 6.6E-25 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Gene3D G3DSA:1.10.155.10 207 273 1.1E-12 T 21-04-2016 IPR022641 Chemotaxis receptor methyltransferase CheR, N-terminal SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Pfam PF13596 PAS domain 725 829 2.8E-24 T 21-04-2016 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SUPERFAMILY SSF47384 1116 1197 1.96E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SMART SM00387 1238 1349 2.3E-35 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SUPERFAMILY SSF52738 10 195 1.44E-49 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1239 1347 8.4E-23 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SMART SM00086 1072 1114 0.74 T 21-04-2016 IPR001610 PAC motif SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SMART SM00086 792 832 9.2 T 21-04-2016 IPR001610 PAC motif SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PANTHER PTHR24422:SF6 104 841 9.7E-175 T 21-04-2016 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Gene3D G3DSA:3.40.50.180 7 195 1.3E-57 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 PANTHER PTHR24422 104 841 9.7E-175 T 21-04-2016 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Pfam PF01339 CheB methylesterase 15 189 7.3E-52 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SMART SM00388 1127 1196 3.0E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Pfam PF00512 His Kinase A (phospho-acceptor) domain 1128 1196 1.5E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SUPERFAMILY SSF47757 207 278 4.84E-11 T 21-04-2016 IPR022641 Chemotaxis receptor methyltransferase CheR, N-terminal SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Pfam PF03705 CheR methyltransferase, all-alpha domain 214 262 2.7E-11 T 21-04-2016 IPR022641 Chemotaxis receptor methyltransferase CheR, N-terminal SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SUPERFAMILY SSF55785 1004 1117 4.01E-18 T 21-04-2016 IPR000014 PAS domain SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Gene3D G3DSA:3.40.50.150 275 470 2.6E-59 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SUPERFAMILY SSF53335 276 470 7.69E-46 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SMART SM00138 210 471 1.2E-68 T 21-04-2016 IPR000780 MCP methyltransferase, CheR-type GO:0008757 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SUPERFAMILY SSF55874 1185 1347 1.83E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 SUPERFAMILY SSF55785 709 824 1.03E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Gene3D G3DSA:3.30.565.10 1183 1349 3.5E-44 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Gene3D G3DSA:3.30.450.20 717 830 5.0E-6 T 21-04-2016 SPH21_RS10615 9a00ce18f424e0b6cc72d284262ef36f 1350 Gene3D G3DSA:1.10.287.130 1127 1182 2.1E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS00185 652bc9a7c84bd16937ef14bb381737a9 299 Gene3D G3DSA:3.20.20.410 33 279 1.2E-64 T 21-04-2016 IPR002763 Protein of unknown function DUF72 SPH21_RS00185 652bc9a7c84bd16937ef14bb381737a9 299 PANTHER PTHR30348 29 257 3.6E-47 T 21-04-2016 SPH21_RS00185 652bc9a7c84bd16937ef14bb381737a9 299 PANTHER PTHR30348:SF3 29 257 3.6E-47 T 21-04-2016 SPH21_RS00185 652bc9a7c84bd16937ef14bb381737a9 299 SUPERFAMILY SSF117396 37 276 1.31E-62 T 21-04-2016 IPR002763 Protein of unknown function DUF72 SPH21_RS00185 652bc9a7c84bd16937ef14bb381737a9 299 Pfam PF01904 Protein of unknown function DUF72 54 272 1.7E-50 T 21-04-2016 IPR002763 Protein of unknown function DUF72 SPH21_RS14775 2990e6efc987cf215d492b71a2db4fad 106 Gene3D G3DSA:3.10.20.30 1 101 2.1E-27 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS14775 2990e6efc987cf215d492b71a2db4fad 106 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 14 90 2.7E-12 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS14775 2990e6efc987cf215d492b71a2db4fad 106 PRINTS PR00355 Adrenodoxin signature 59 73 1.1E-7 T 21-04-2016 IPR001055 Adrenodoxin GO:0009055|GO:0051537 SPH21_RS14775 2990e6efc987cf215d492b71a2db4fad 106 PRINTS PR00355 Adrenodoxin signature 41 51 1.1E-7 T 21-04-2016 IPR001055 Adrenodoxin GO:0009055|GO:0051537 SPH21_RS14775 2990e6efc987cf215d492b71a2db4fad 106 PRINTS PR00355 Adrenodoxin signature 82 90 1.1E-7 T 21-04-2016 IPR001055 Adrenodoxin GO:0009055|GO:0051537 SPH21_RS14775 2990e6efc987cf215d492b71a2db4fad 106 SUPERFAMILY SSF54292 5 100 5.29E-24 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS14775 2990e6efc987cf215d492b71a2db4fad 106 PANTHER PTHR23426 1 101 2.0E-19 T 21-04-2016 SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 5 130 3.6E-24 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 SUPERFAMILY SSF51735 3 165 1.1E-49 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 Gene3D G3DSA:3.40.50.720 1 152 2.6E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 Gene3D G3DSA:3.30.360.10 153 282 5.1E-42 T 21-04-2016 SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 Gene3D G3DSA:3.30.360.10 330 379 5.1E-42 T 21-04-2016 SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 PANTHER PTHR22604 1 385 3.0E-99 T 21-04-2016 SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 PANTHER PTHR22604:SF123 1 385 3.0E-99 T 21-04-2016 SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 SUPERFAMILY SSF55347 138 302 6.21E-32 T 21-04-2016 SPH21_RS02235 0d8ed9f679286a9cd8a25f53f6d265a3 387 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 144 250 8.7E-7 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS17935 2116161c589e5e4089051cab4de490b0 195 Gene3D G3DSA:3.40.30.10 13 188 2.0E-43 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17935 2116161c589e5e4089051cab4de490b0 195 SUPERFAMILY SSF52833 47 189 8.73E-34 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17935 2116161c589e5e4089051cab4de490b0 195 PANTHER PTHR10681 31 166 7.1E-19 T 21-04-2016 SPH21_RS17935 2116161c589e5e4089051cab4de490b0 195 Pfam PF00578 AhpC/TSA family 48 160 1.8E-19 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS17935 2116161c589e5e4089051cab4de490b0 195 PANTHER PTHR10681:SF68 31 166 7.1E-19 T 21-04-2016 SPH21_RS01595 5b0a60bbf9af840013ceb81df76f26fd 134 ProSitePatterns PS00648 Bacterial ribonuclease P protein component signature. 58 72 - T 21-04-2016 IPR020539 Ribonuclease P, conserved site GO:0004526 SPH21_RS01595 5b0a60bbf9af840013ceb81df76f26fd 134 Pfam PF00825 Ribonuclease P 6 84 3.9E-13 T 21-04-2016 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 SPH21_RS01595 5b0a60bbf9af840013ceb81df76f26fd 134 Hamap MF_00227 Ribonuclease P protein component [rnpA]. 6 124 11.201 T 21-04-2016 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 SPH21_RS01595 5b0a60bbf9af840013ceb81df76f26fd 134 Gene3D G3DSA:3.30.230.10 2 123 3.9E-21 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS01595 5b0a60bbf9af840013ceb81df76f26fd 134 ProDom PD003629 P RIBONUCLEASE COMPONENT HYDROLASE RNASE C5 RNASEP RNA-BINDING PROCESSING ENDONUCLEASE 48 85 0.001 T 21-04-2016 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 SPH21_RS01595 5b0a60bbf9af840013ceb81df76f26fd 134 SUPERFAMILY SSF54211 4 122 3.54E-13 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS10960 ab199d00b696870ae5b40419ba69acf5 345 Gene3D G3DSA:3.30.70.1070 268 335 4.1E-4 T 21-04-2016 IPR007730 Sporulation-related domain GO:0042834 SPH21_RS10960 ab199d00b696870ae5b40419ba69acf5 345 SUPERFAMILY SSF110997 271 343 2.62E-5 T 21-04-2016 IPR007730 Sporulation-related domain GO:0042834 SPH21_RS15835 943090df7777e35790e049081057e094 194 Pfam PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 25 131 9.1E-33 T 21-04-2016 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 SPH21_RS15835 943090df7777e35790e049081057e094 194 PANTHER PTHR11058 1 135 2.5E-39 T 21-04-2016 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 SPH21_RS15835 943090df7777e35790e049081057e094 194 Hamap MF_01394 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic [ndhC]. 6 132 17.976 T 21-04-2016 IPR023043 NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid GO:0016651|GO:0055114 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 SUPERFAMILY SSF51735 6 198 3.54E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 Pfam PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 197 494 9.6E-124 T 21-04-2016 IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 Pfam PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 13 195 2.1E-59 T 21-04-2016 IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 ProSitePatterns PS00069 Glucose-6-phosphate dehydrogenase active site. 185 191 - T 21-04-2016 IPR019796 Glucose-6-phosphate dehydrogenase, active site GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 Gene3D G3DSA:3.40.50.720 7 194 5.5E-66 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PANTHER PTHR23429 5 503 1.3E-231 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 SUPERFAMILY SSF55347 190 495 5.89E-118 T 21-04-2016 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 TIGRFAM TIGR00871 zwf: glucose-6-phosphate dehydrogenase 9 495 5.3E-193 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PIRSF PIRSF000110 1 498 9.4E-189 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 227 244 5.4E-49 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 151 164 5.4E-49 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 245 261 5.4E-49 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 336 362 5.4E-49 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 175 203 5.4E-49 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 Hamap MF_00966 Glucose-6-phosphate 1-dehydrogenase [zwf]. 9 496 83.82 T 21-04-2016 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268|UniPathway: UPA00115 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 PANTHER PTHR23429:SF0 5 503 1.3E-231 T 21-04-2016 SPH21_RS21180 b0ba9d5fe97358066e7592b65b0e89f3 504 Gene3D G3DSA:3.30.360.10 195 495 1.6E-127 T 21-04-2016 SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 SUPERFAMILY SSF52540 18 161 1.26E-15 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 Hamap MF_00185 tRNA dimethylallyltransferase [miaA]. 18 306 27.053 T 21-04-2016 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781 SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 Pfam PF01715 IPP transferase 51 291 7.2E-74 T 21-04-2016 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781 SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 PANTHER PTHR11088 5 307 1.4E-84 T 21-04-2016 SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 TIGRFAM TIGR00174 miaA: tRNA dimethylallyltransferase 19 300 3.9E-84 T 21-04-2016 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781 SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 Gene3D G3DSA:3.40.50.300 16 185 9.8E-45 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 Gene3D G3DSA:1.10.287.890 212 290 1.7E-28 T 21-04-2016 SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 SUPERFAMILY SSF52540 17 76 2.09E-8 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 SUPERFAMILY SSF52540 203 280 2.09E-8 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11990 adb806d0812a22bf4c48ffd514331e3f 313 PANTHER PTHR11088:SF25 5 307 1.4E-84 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Pfam PF13715 CarboxypepD_reg-like domain 26 107 1.3E-18 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 SUPERFAMILY SSF49464 25 105 1.96E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Gene3D G3DSA:2.40.170.20 908 1075 7.7E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Gene3D G3DSA:2.40.170.20 335 414 7.7E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Gene3D G3DSA:2.40.170.20 456 818 7.7E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Gene3D G3DSA:2.40.170.20 239 259 7.7E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 239 9.7E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Gene3D G3DSA:2.60.40.1120 25 110 1.5E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Gene3D G3DSA:2.170.130.10 111 238 1.8E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 25 1075 4.4E-238 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532:SF57 486 882 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532:SF57 898 1073 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532:SF57 206 380 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532:SF57 1 189 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 215 245 6.3E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532 486 882 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532 898 1073 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532 206 380 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 PANTHER PTHR11532 1 189 1.0E-221 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 SUPERFAMILY SSF56935 982 1075 1.42E-91 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 SUPERFAMILY SSF56935 104 263 1.42E-91 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 SUPERFAMILY SSF56935 461 808 1.42E-91 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 SUPERFAMILY SSF56935 899 943 1.42E-91 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 SUPERFAMILY SSF56935 326 414 1.42E-91 T 21-04-2016 SPH21_RS05395 77b75155b2f194b2ba8c493aa7a7ae47 1075 Pfam PF00593 TonB dependent receptor 658 1073 1.7E-19 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 PANTHER PTHR11908 1 135 1.2E-32 T 21-04-2016 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 PANTHER PTHR11908:SF66 1 135 1.2E-32 T 21-04-2016 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 SUPERFAMILY SSF47741 74 150 2.88E-31 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 Pfam PF01799 [2Fe-2S] binding domain 74 146 1.1E-27 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 SUPERFAMILY SSF54292 3 79 3.54E-25 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 40 48 - T 21-04-2016 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 Gene3D G3DSA:1.10.150.120 76 150 1.3E-30 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 Gene3D G3DSA:3.10.20.30 3 75 1.8E-28 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS00670 af0123950b8faa89ab139b7e39269544 151 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 7 60 2.8E-8 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 PANTHER PTHR11766 1 428 1.0E-185 T 21-04-2016 IPR024088 Tyrosine-tRNA ligase, bacterial-type GO:0004831 KEGG: 00970+6.1.1.1 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 SUPERFAMILY SSF55174 334 428 2.88E-16 T 21-04-2016 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 37 47 - T 21-04-2016 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 Hamap MF_02006 Tyrosine--tRNA ligase [tyrS]. 1 429 42.513 T 21-04-2016 IPR024107 Tyrosine-tRNA ligase, bacterial-type, type 1 GO:0004831 KEGG: 00970+6.1.1.1 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 41 63 7.7E-27 T 21-04-2016 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1|Reactome: REACT_71 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 218 230 7.7E-27 T 21-04-2016 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1|Reactome: REACT_71 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 185 207 7.7E-27 T 21-04-2016 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1|Reactome: REACT_71 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 164 179 7.7E-27 T 21-04-2016 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1|Reactome: REACT_71 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 Gene3D G3DSA:1.10.240.10 235 318 1.4E-33 T 21-04-2016 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 Gene3D G3DSA:3.40.50.620 2 234 7.7E-97 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 Pfam PF00579 tRNA synthetases class I (W and Y) 31 321 3.9E-73 T 21-04-2016 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 Gene3D G3DSA:3.10.290.10 319 429 2.3E-25 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 SUPERFAMILY SSF52374 1 325 3.06E-92 T 21-04-2016 SPH21_RS19400 770df790903694cc2b2b9c701f8a302b 430 TIGRFAM TIGR00234 tyrS: tyrosine--tRNA ligase 2 427 5.3E-117 T 21-04-2016 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1|Reactome: REACT_71 SPH21_RS05005 aa1797224252c1afd4d427fc313bfb4f 469 PIRSF PIRSF006060 1 469 1.9E-79 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS05005 aa1797224252c1afd4d427fc313bfb4f 469 PANTHER PTHR11785 2 462 3.5E-100 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS05005 aa1797224252c1afd4d427fc313bfb4f 469 Pfam PF13520 Amino acid permease 12 455 1.7E-62 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 Pfam PF02096 60Kd inner membrane protein 370 563 2.2E-49 T 21-04-2016 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 Hamap MF_01810 Membrane protein insertase YidC [yidC]. 3 566 13.911 T 21-04-2016 IPR019998 Membrane insertase YidC GO:0016021|GO:0051205 SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 TIGRFAM TIGR03593 yidC_nterm: membrane protein insertase, YidC/Oxa1 family, N-terminal domain 2 364 2.5E-26 T 21-04-2016 IPR028053 Membrane insertase YidC, N-terminal SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 PANTHER PTHR12428:SF14 348 604 6.5E-57 T 21-04-2016 SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 PANTHER PTHR12428 348 604 6.5E-57 T 21-04-2016 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 TIGRFAM TIGR03592 yidC_oxa1_cterm: membrane protein insertase, YidC/Oxa1 family 369 563 1.4E-51 T 21-04-2016 IPR028055 Membrane insertase YidC/Oxa1, C-terminal SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 Pfam PF14849 YidC periplasmic domain 87 355 9.4E-23 T 21-04-2016 IPR028053 Membrane insertase YidC, N-terminal SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 PRINTS PR00701 60kDa inner membrane protein signature 262 277 1.6E-10 T 21-04-2016 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 PRINTS PR00701 60kDa inner membrane protein signature 92 113 1.6E-10 T 21-04-2016 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 SPH21_RS17515 31de03569617546ad57a72fae28f426b 609 PRINTS PR00701 60kDa inner membrane protein signature 432 455 1.6E-10 T 21-04-2016 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 Gene3D G3DSA:1.20.1050.60 369 459 5.5E-27 T 21-04-2016 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 PANTHER PTHR12143 409 751 2.4E-155 T 21-04-2016 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 PANTHER PTHR12143 1 393 2.4E-155 T 21-04-2016 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 Gene3D G3DSA:1.20.1610.10 468 609 5.5E-52 T 21-04-2016 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 PANTHER PTHR12143:SF22 409 751 2.4E-155 T 21-04-2016 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 PANTHER PTHR12143:SF22 1 393 2.4E-155 T 21-04-2016 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 Pfam PF07971 Glycosyl hydrolase family 92 264 744 1.9E-165 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 12 748 1.5E-164 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 Gene3D G3DSA:2.70.98.10 26 343 3.1E-78 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 SUPERFAMILY SSF48208 278 730 5.1E-18 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02490 407677eade1030427eeaadd169b8b78e 764 Gene3D G3DSA:3.30.2080.10 610 756 3.9E-59 T 21-04-2016 SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 PANTHER PTHR34698:SF2 11 252 1.8E-82 T 21-04-2016 SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 SMART SM00796 16 227 7.1E-77 T 21-04-2016 IPR003833 Carboxyltransferase domain, subdomain C and D SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 SUPERFAMILY SSF160467 18 118 7.98E-13 T 21-04-2016 SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 TIGRFAM TIGR00370 TIGR00370: sensor histidine kinase inhibitor, KipI family 21 235 2.0E-60 T 21-04-2016 IPR010016 KipI family SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 SUPERFAMILY SSF50891 114 243 2.92E-42 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 Gene3D G3DSA:3.30.1360.40 18 102 1.2E-16 T 21-04-2016 IPR024946 Arginine repressor C-terminal-like domain SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 Gene3D G3DSA:2.40.100.10 113 249 5.1E-48 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 Pfam PF02682 Allophanate hydrolase subunit 1 17 227 1.3E-67 T 21-04-2016 IPR003833 Carboxyltransferase domain, subdomain C and D SPH21_RS13450 63d45d2bdc0b5b1230cdc9f707ff1307 252 PANTHER PTHR34698 11 252 1.8E-82 T 21-04-2016 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 SUPERFAMILY SSF53098 2 207 1.67E-61 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 SUPERFAMILY SSF53098 357 630 1.67E-61 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 Pfam PF14579 Helix-hairpin-helix motif 1097 1185 3.7E-26 T 21-04-2016 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 260 1280 0.0 T 21-04-2016 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 Pfam PF00929 Exonuclease 3 182 1.3E-9 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 PANTHER PTHR32294:SF0 1318 1493 0.0 T 21-04-2016 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 PANTHER PTHR32294:SF0 256 1282 0.0 T 21-04-2016 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 Gene3D G3DSA:3.20.20.140 261 540 9.0E-35 T 21-04-2016 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 SMART SM00479 1 192 7.1E-14 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 587 1023 1.7E-160 T 21-04-2016 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 SMART SM00481 261 349 1.3E-13 T 21-04-2016 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 Gene3D G3DSA:3.30.420.10 1 189 1.4E-34 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 Pfam PF02811 PHP domain 262 451 2.0E-42 T 21-04-2016 IPR004013 PHP domain GO:0003824 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 Gene3D G3DSA:1.10.150.280 1125 1172 5.5E-5 T 21-04-2016 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 PANTHER PTHR32294 1318 1493 0.0 T 21-04-2016 SPH21_RS19475 1c4661a0420d47587504d81eea3501b7 1493 PANTHER PTHR32294 256 1282 0.0 T 21-04-2016 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 PANTHER PTHR10909:SF10 1 380 3.6E-177 T 21-04-2016 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 336 355 - T 21-04-2016 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 SUPERFAMILY SSF47203 229 380 2.9E-62 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 124 136 - T 21-04-2016 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 122 217 2.0E-27 T 21-04-2016 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 SUPERFAMILY SSF56645 1 242 1.44E-81 T 21-04-2016 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 PIRSF PIRSF016578 6 381 1.7E-21 T 21-04-2016 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 Gene3D G3DSA:1.10.540.10 1 118 8.2E-41 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 Gene3D G3DSA:1.20.140.10 217 380 1.8E-75 T 21-04-2016 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 Gene3D G3DSA:2.40.110.10 121 216 9.7E-39 T 21-04-2016 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 PANTHER PTHR10909 1 380 3.6E-177 T 21-04-2016 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 117 2.0E-35 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS08130 473edf897ed35646340b9f70e84cdb5e 382 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 231 378 6.5E-55 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SUPERFAMILY SSF81901 256 466 4.6E-27 T 21-04-2016 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Gene3D G3DSA:1.25.40.10 251 468 2.5E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Gene3D G3DSA:1.25.40.10 471 691 4.7E-51 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Gene3D G3DSA:1.25.40.10 692 820 6.8E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Gene3D G3DSA:1.25.40.10 93 165 2.2E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SUPERFAMILY SSF81901 471 672 1.9E-36 T 21-04-2016 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 674 706 6.0 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 598 636 3.3E-5 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 562 597 0.0034 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 343 378 0.0035 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 707 742 1.6E-8 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 489 525 1.5 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 637 672 5.6 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 454 488 1.5E-4 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 418 453 3.6E-4 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 743 778 1.4E-7 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 779 814 2.9E-9 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 136 169 29.0 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 380 417 0.0077 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SMART SM00671 526 561 2.2E-7 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 677 705 5.9E-5 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 745 776 4.8E-6 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 567 597 57.0 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 308 341 38.0 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 530 561 3.0E-7 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 380 417 9.4E-4 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 422 451 4.7 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 458 487 0.0028 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 143 163 7.0 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 638 671 4.8 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 489 523 5.4E-4 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 779 814 4.0E-9 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 709 742 6.2E-8 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 351 376 0.026 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 Pfam PF08238 Sel1 repeat 598 636 1.8E-6 T 21-04-2016 IPR006597 Sel1-like repeat SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SUPERFAMILY SSF81901 93 236 4.32E-5 T 21-04-2016 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 PANTHER PTHR11102 3 38 1.5E-66 T 21-04-2016 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 PANTHER PTHR11102 432 815 1.5E-66 T 21-04-2016 SPH21_RS13980 b0f22d711aac8471842c8ec62671b03c 826 SUPERFAMILY SSF81901 692 821 5.84E-33 T 21-04-2016 SPH21_RS26250 75741bec9d44132c60f025266817743e 234 Pfam PF16344 Domain of unknown function (DUF4974) 133 232 1.3E-11 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS26250 75741bec9d44132c60f025266817743e 234 PANTHER PTHR30273:SF2 1 234 7.8E-47 T 21-04-2016 SPH21_RS26250 75741bec9d44132c60f025266817743e 234 PANTHER PTHR30273 1 234 7.8E-47 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26250 75741bec9d44132c60f025266817743e 234 Pfam PF04773 FecR protein 28 120 3.0E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS11420 b6c0131013197fa3bd76a53ba8f16047 377 PANTHER PTHR33307:SF3 28 350 6.7E-114 T 21-04-2016 SPH21_RS11420 b6c0131013197fa3bd76a53ba8f16047 377 PANTHER PTHR33307 28 350 6.7E-114 T 21-04-2016 SPH21_RS11420 b6c0131013197fa3bd76a53ba8f16047 377 Gene3D G3DSA:2.120.10.10 33 349 1.0E-72 T 21-04-2016 IPR011040 Sialidases SPH21_RS11420 b6c0131013197fa3bd76a53ba8f16047 377 SUPERFAMILY SSF50939 34 348 3.92E-57 T 21-04-2016 IPR011040 Sialidases SPH21_RS11420 b6c0131013197fa3bd76a53ba8f16047 377 Pfam PF13088 BNR repeat-like domain 56 328 4.7E-97 T 21-04-2016 IPR011040 Sialidases SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 SUPERFAMILY SSF51126 9 119 9.92E-35 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 SUPERFAMILY SSF51126 349 587 9.92E-35 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 Gene3D G3DSA:2.160.20.10 11 159 7.0E-26 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 Gene3D G3DSA:2.160.20.10 397 601 7.0E-26 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 Pfam PF13229 Right handed beta helix region 377 547 1.8E-6 T 21-04-2016 SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 PANTHER PTHR36453 376 609 5.9E-120 T 21-04-2016 SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 PANTHER PTHR36453 21 358 5.9E-120 T 21-04-2016 SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 SMART SM00710 383 405 7300.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 SMART SM00710 407 429 38.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 SMART SM00710 450 475 520.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 SMART SM00710 478 499 1300.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 PANTHER PTHR36453:SF1 376 609 5.9E-120 T 21-04-2016 SPH21_RS11485 6d5b9fe9da7d54ef90c3d82ce6998fb7 633 PANTHER PTHR36453:SF1 21 358 5.9E-120 T 21-04-2016 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 SUPERFAMILY SSF56024 273 473 7.63E-49 T 21-04-2016 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 Pfam PF13396 Phospholipase_D-nuclease N-terminal 17 57 6.6E-6 T 21-04-2016 IPR027379 Cardiolipin synthase N-terminal SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 Gene3D G3DSA:3.30.870.10 116 317 3.4E-52 T 21-04-2016 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 Gene3D G3DSA:3.30.870.10 322 484 1.1E-38 T 21-04-2016 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 TIGRFAM TIGR04265 bac_cardiolipin: cardiolipin synthase 9 486 1.2E-142 T 21-04-2016 IPR022924 Cardiolipin synthase GO:0008808|GO:0016780|GO:0032049 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 SUPERFAMILY SSF56024 115 316 1.57E-52 T 21-04-2016 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 Pfam PF13091 PLD-like domain 326 453 8.4E-29 T 21-04-2016 IPR025202 Phospholipase D-like domain SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 Pfam PF13091 PLD-like domain 136 261 4.6E-16 T 21-04-2016 IPR025202 Phospholipase D-like domain SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 PANTHER PTHR21248:SF5 16 486 4.2E-114 T 21-04-2016 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 SMART SM00155 219 246 6.4E-6 T 21-04-2016 IPR001736 Phospholipase D/Transphosphatidylase GO:0003824 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 SMART SM00155 399 426 2.6E-6 T 21-04-2016 IPR001736 Phospholipase D/Transphosphatidylase GO:0003824 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 PANTHER PTHR21248 16 486 4.2E-114 T 21-04-2016 SPH21_RS19995 b552d73b114978b7b4b50799b064a4d7 486 Hamap MF_01916 Cardiolipin synthase. 11 486 38.278 T 21-04-2016 IPR030874 Cardiolipin synthase, Firmicutes-type GO:0008808|GO:0032049 SPH21_RS26185 c65a5fd58e5aa9da90ba169e2ce05527 335 PIRSF PIRSF018266 2 335 4.2E-62 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26185 c65a5fd58e5aa9da90ba169e2ce05527 335 PANTHER PTHR30273:SF2 1 335 2.3E-73 T 21-04-2016 SPH21_RS26185 c65a5fd58e5aa9da90ba169e2ce05527 335 Pfam PF16344 Domain of unknown function (DUF4974) 236 331 3.0E-19 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS26185 c65a5fd58e5aa9da90ba169e2ce05527 335 PANTHER PTHR30273 1 335 2.3E-73 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26185 c65a5fd58e5aa9da90ba169e2ce05527 335 Pfam PF04773 FecR protein 112 205 5.9E-20 T 21-04-2016 IPR006860 FecR protein SPH21_RS24305 ca5a8d02f041f69ddea044170a6dbafa 99 Pfam PF05717 IS66 Orf2 like protein 1 83 2.0E-27 T 21-04-2016 IPR008878 Transposase IS66, Orf2 SPH21_RS24305 ca5a8d02f041f69ddea044170a6dbafa 99 PANTHER PTHR36455 1 81 1.3E-20 T 21-04-2016 SPH21_RS24305 ca5a8d02f041f69ddea044170a6dbafa 99 PANTHER PTHR36455:SF1 1 81 1.3E-20 T 21-04-2016 SPH21_RS24970 ca5a8d02f041f69ddea044170a6dbafa 99 Pfam PF05717 IS66 Orf2 like protein 1 83 2.0E-27 T 21-04-2016 IPR008878 Transposase IS66, Orf2 SPH21_RS24970 ca5a8d02f041f69ddea044170a6dbafa 99 PANTHER PTHR36455 1 81 1.3E-20 T 21-04-2016 SPH21_RS24970 ca5a8d02f041f69ddea044170a6dbafa 99 PANTHER PTHR36455:SF1 1 81 1.3E-20 T 21-04-2016 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 PANTHER PTHR33751:SF1 85 276 1.9E-43 T 21-04-2016 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 Gene3D G3DSA:1.10.760.10 121 142 5.1E-32 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 Gene3D G3DSA:1.10.760.10 179 275 5.1E-32 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 Pfam PF14715 N-terminal domain of cytochrome oxidase-cbb3, FixP 99 142 3.0E-18 T 21-04-2016 IPR032858 Cbb3-type cytochrome c oxidase subunit CcoP, N-terminal UniPathway: UPA00705 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 SUPERFAMILY SSF46626 165 269 3.25E-27 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 SUPERFAMILY SSF46626 116 138 3.25E-27 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III 185 258 3.8E-15 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17560 eaa5ae65c874634e4ed25105102fa5d4 284 PANTHER PTHR33751 85 276 1.9E-43 T 21-04-2016 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 PANTHER PTHR30173:SF15 3 335 9.0E-77 T 21-04-2016 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 Gene3D G3DSA:1.25.40.10 292 388 9.5E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 Gene3D G3DSA:1.10.1740.10 13 59 4.0E-8 T 21-04-2016 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 PANTHER PTHR30173 3 335 9.0E-77 T 21-04-2016 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 14 150 5.6E-13 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 Gene3D G3DSA:1.10.10.10 107 150 2.3E-7 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 Pfam PF04542 Sigma-70 region 2 11 59 1.9E-7 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 SUPERFAMILY SSF88946 12 61 2.24E-9 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21375 65f4bf4d5793965cdd733ef7bde5de2d 395 SUPERFAMILY SSF88659 92 150 2.18E-6 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09775 508bf97277677d051f4efc988bb8973a 355 Gene3D G3DSA:3.20.20.80 201 332 4.8E-10 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS09775 508bf97277677d051f4efc988bb8973a 355 SUPERFAMILY SSF51445 54 337 1.42E-24 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS09775 508bf97277677d051f4efc988bb8973a 355 Pfam PF11790 Glycosyl hydrolase catalytic core 214 313 4.4E-11 T 21-04-2016 IPR024655 Uncharacterised protein family, glycosyl hydrolase catalytic domain SPH21_RS21645 3362377bd1e9ae74d1e8495e4347815a 192 SUPERFAMILY SSF48498 78 190 5.56E-11 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS21645 3362377bd1e9ae74d1e8495e4347815a 192 Gene3D G3DSA:1.10.10.60 1 57 3.1E-17 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21645 3362377bd1e9ae74d1e8495e4347815a 192 Gene3D G3DSA:1.10.357.10 58 187 3.5E-13 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS21645 3362377bd1e9ae74d1e8495e4347815a 192 SUPERFAMILY SSF46689 2 72 3.08E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21645 3362377bd1e9ae74d1e8495e4347815a 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 56 4.0E-8 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS21645 3362377bd1e9ae74d1e8495e4347815a 192 PANTHER PTHR30055:SF44 1 188 9.4E-37 T 21-04-2016 SPH21_RS21645 3362377bd1e9ae74d1e8495e4347815a 192 PANTHER PTHR30055 1 188 9.4E-37 T 21-04-2016 SPH21_RS07045 e3619c402b40d8e457fd9372b34d0c74 187 Pfam PF01765 Ribosome recycling factor 24 185 6.9E-64 T 21-04-2016 IPR023584 Ribosome recycling factor domain SPH21_RS07045 e3619c402b40d8e457fd9372b34d0c74 187 TIGRFAM TIGR00496 frr: ribosome recycling factor 14 187 1.5E-68 T 21-04-2016 IPR002661 Ribosome recycling factor GO:0006412 SPH21_RS07045 e3619c402b40d8e457fd9372b34d0c74 187 PANTHER PTHR20982 3 187 1.1E-80 T 21-04-2016 IPR002661 Ribosome recycling factor GO:0006412 SPH21_RS07045 e3619c402b40d8e457fd9372b34d0c74 187 Gene3D G3DSA:1.10.132.20 69 187 4.2E-42 T 21-04-2016 IPR023584 Ribosome recycling factor domain SPH21_RS07045 e3619c402b40d8e457fd9372b34d0c74 187 SUPERFAMILY SSF55194 6 186 4.32E-69 T 21-04-2016 IPR023584 Ribosome recycling factor domain SPH21_RS07045 e3619c402b40d8e457fd9372b34d0c74 187 Hamap MF_00040 Ribosome-recycling factor [frr]. 6 187 26.843 T 21-04-2016 IPR002661 Ribosome recycling factor GO:0006412 SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 Gene3D G3DSA:2.60.120.560 380 516 3.0E-7 T 21-04-2016 IPR013189 Glycosyl hydrolase family 32, C-terminal SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 Pfam PF00251 Glycosyl hydrolases family 32 N-terminal domain 121 406 1.0E-75 T 21-04-2016 IPR013148 Glycosyl hydrolase family 32, N-terminal SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 Gene3D G3DSA:2.115.10.20 126 333 4.1E-12 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 SMART SM00640 121 507 6.1E-94 T 21-04-2016 IPR001362 Glycoside hydrolase, family 32 GO:0004553|GO:0005975 SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 PANTHER PTHR30175 108 546 2.7E-114 T 21-04-2016 SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 SUPERFAMILY SSF75005 111 407 2.04E-93 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 PANTHER PTHR30175:SF0 108 546 2.7E-114 T 21-04-2016 SPH21_RS23590 d1b994003a250dbd1ec7195fe83fa403 547 SUPERFAMILY SSF49899 406 546 9.5E-12 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 SUPERFAMILY SSF82693 44 128 1.41E-20 T 21-04-2016 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 PANTHER PTHR32063:SF19 2 423 6.0E-216 T 21-04-2016 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 Gene3D G3DSA:1.10.3850.10 279 421 5.7E-40 T 21-04-2016 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 PANTHER PTHR32063 2 423 6.0E-216 T 21-04-2016 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 SUPERFAMILY SSF82693 138 182 1.54E-17 T 21-04-2016 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 SUPERFAMILY SSF82693 268 324 1.54E-17 T 21-04-2016 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 Pfam PF00873 AcrB/AcrD/AcrF family 6 430 3.8E-109 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 PRINTS PR00702 Acriflavin resistance protein family signature 40 58 6.5E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 PRINTS PR00702 Acriflavin resistance protein family signature 358 379 6.5E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 PRINTS PR00702 Acriflavin resistance protein family signature 331 354 6.5E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 PRINTS PR00702 Acriflavin resistance protein family signature 386 410 6.5E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 PRINTS PR00702 Acriflavin resistance protein family signature 12 36 6.5E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 Gene3D G3DSA:3.30.2090.10 182 265 2.6E-19 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 Gene3D G3DSA:3.30.70.1430 45 142 3.1E-24 T 21-04-2016 SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 SUPERFAMILY SSF82714 183 265 3.66E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01410 5b8a21c0e192a5021b4b62f86c574d77 432 SUPERFAMILY SSF82866 291 421 2.22E-26 T 21-04-2016 SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 SUPERFAMILY SSF48334 131 302 1.18E-11 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 Gene3D G3DSA:1.10.1420.10 132 185 4.2E-11 T 21-04-2016 SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 Gene3D G3DSA:3.40.50.300 384 596 2.5E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 SMART SM00534 421 598 3.6E-11 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 SUPERFAMILY SSF52540 384 596 6.48E-33 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 PANTHER PTHR11361 131 582 2.6E-57 T 21-04-2016 SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 SMART SM00533 129 408 0.0029 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 Pfam PF05192 MutS domain III 131 227 1.3E-10 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS21805 5f5560f42f25eea5cfbad95a9f2bbdc6 598 Pfam PF00488 MutS domain V 425 595 3.0E-27 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS09055 5b6dd3c0fe78bb28de559587bfeb3162 299 PANTHER PTHR10366:SF329 273 287 1.9E-40 T 21-04-2016 SPH21_RS09055 5b6dd3c0fe78bb28de559587bfeb3162 299 PANTHER PTHR10366:SF329 3 240 1.9E-40 T 21-04-2016 SPH21_RS09055 5b6dd3c0fe78bb28de559587bfeb3162 299 PANTHER PTHR10366 273 287 1.9E-40 T 21-04-2016 SPH21_RS09055 5b6dd3c0fe78bb28de559587bfeb3162 299 PANTHER PTHR10366 3 240 1.9E-40 T 21-04-2016 SPH21_RS09055 5b6dd3c0fe78bb28de559587bfeb3162 299 Gene3D G3DSA:3.40.50.720 3 295 2.7E-37 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09055 5b6dd3c0fe78bb28de559587bfeb3162 299 SUPERFAMILY SSF51735 3 298 6.5E-46 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09055 5b6dd3c0fe78bb28de559587bfeb3162 299 Pfam PF01370 NAD dependent epimerase/dehydratase family 4 208 1.1E-18 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS16775 9aa6e2e2574dde206c9efe63579e0d02 481 PANTHER PTHR34595 7 481 1.2E-267 T 21-04-2016 SPH21_RS16775 9aa6e2e2574dde206c9efe63579e0d02 481 Pfam PF14403 Circularly permuted ATP-grasp type 2 82 458 4.3E-160 T 21-04-2016 IPR025841 Circularly permuted ATP-grasp type 2 SPH21_RS16775 9aa6e2e2574dde206c9efe63579e0d02 481 SUPERFAMILY SSF56059 327 472 1.44E-57 T 21-04-2016 SPH21_RS16775 9aa6e2e2574dde206c9efe63579e0d02 481 SUPERFAMILY SSF56059 25 220 1.44E-57 T 21-04-2016 SPH21_RS16775 9aa6e2e2574dde206c9efe63579e0d02 481 PANTHER PTHR34595:SF3 7 481 1.2E-267 T 21-04-2016 SPH21_RS16775 9aa6e2e2574dde206c9efe63579e0d02 481 PIRSF PIRSF005522 3 481 4.3E-217 T 21-04-2016 IPR016450 Uncharacterised conserved protein UCP005522 SPH21_RS00190 cfd635d75b57e6821d62d01080e028a8 319 PANTHER PTHR12147 103 299 4.2E-40 T 21-04-2016 SPH21_RS00190 cfd635d75b57e6821d62d01080e028a8 319 SUPERFAMILY SSF53187 35 305 1.5E-58 T 21-04-2016 SPH21_RS00190 cfd635d75b57e6821d62d01080e028a8 319 Gene3D G3DSA:3.40.630.10 27 314 1.0E-59 T 21-04-2016 SPH21_RS00190 cfd635d75b57e6821d62d01080e028a8 319 Pfam PF04389 Peptidase family M28 103 302 3.1E-46 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 SUPERFAMILY SSF53790 6 250 8.37E-65 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 Gene3D G3DSA:3.40.1010.10 11 125 1.5E-38 T 21-04-2016 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 Gene3D G3DSA:3.30.950.10 126 249 1.7E-32 T 21-04-2016 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 PANTHER PTHR21091 1 241 8.8E-62 T 21-04-2016 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 ProSitePatterns PS00840 Uroporphyrin-III C-methyltransferase signature 2. 90 123 - T 21-04-2016 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1. 15 29 - T 21-04-2016 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 11 217 1.1E-40 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 TIGRFAM TIGR01469 cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase 11 244 4.9E-81 T 21-04-2016 IPR006366 Uroporphyrin-III C-methyltransferase GO:0006779|GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS15895 8e9d8368354b9491c3b8457cba449415 260 PANTHER PTHR21091:SF16 1 241 8.8E-62 T 21-04-2016 SPH21_RS07655 eb0862d8d777451ad95a67c540190626 326 SUPERFAMILY SSF52467 9 325 1.08E-81 T 21-04-2016 IPR029035 DHS-like NAD/FAD-binding domain SPH21_RS07655 eb0862d8d777451ad95a67c540190626 326 Gene3D G3DSA:3.40.910.10 8 325 7.9E-75 T 21-04-2016 IPR002773 Deoxyhypusine synthase GO:0008612 UniPathway: UPA00354 SPH21_RS07655 eb0862d8d777451ad95a67c540190626 326 PANTHER PTHR11703 38 321 3.2E-47 T 21-04-2016 IPR002773 Deoxyhypusine synthase GO:0008612 UniPathway: UPA00354 SPH21_RS07655 eb0862d8d777451ad95a67c540190626 326 Pfam PF01916 Deoxyhypusine synthase 18 321 9.2E-38 T 21-04-2016 IPR002773 Deoxyhypusine synthase GO:0008612 UniPathway: UPA00354 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 SUPERFAMILY SSF56925 39 265 1.91E-5 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 PRINTS PR01021 OMPA domain signature 363 385 3.3E-12 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 PRINTS PR01021 OMPA domain signature 392 407 3.3E-12 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 PRINTS PR01021 OMPA domain signature 407 423 3.3E-12 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 SUPERFAMILY SSF103088 357 460 7.72E-28 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 Gene3D G3DSA:4.10.1080.10 313 342 5.2E-6 T 21-04-2016 IPR028974 TSP type-3 repeat GO:0005509 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 Pfam PF13505 Outer membrane protein beta-barrel domain 16 248 1.2E-7 T 21-04-2016 IPR027385 Outer membrane protein beta-barrel SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 SUPERFAMILY SSF103647 311 344 5.1E-8 T 21-04-2016 IPR028974 TSP type-3 repeat GO:0005509 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 Gene3D G3DSA:3.30.1330.60 360 461 5.8E-29 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 Gene3D G3DSA:2.40.160.20 77 247 2.3E-5 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 Pfam PF00691 OmpA family 363 456 7.8E-21 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS05680 81a132d03342e429e0b8138ab7c545f2 462 PANTHER PTHR30128 358 456 4.4E-32 T 21-04-2016 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 56 379 2.2E-47 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 ProSitePatterns PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 83 97 - T 21-04-2016 IPR006653 Tryptophan synthase, beta chain, conserved site GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 PANTHER PTHR10314 10 390 1.2E-212 T 21-04-2016 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 Hamap MF_00133 Tryptophan synthase beta chain [trpB]. 5 392 50.447 T 21-04-2016 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 SUPERFAMILY SSF53686 8 392 4.58E-138 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 PANTHER PTHR10314:SF3 10 390 1.2E-212 T 21-04-2016 IPR006654 Tryptophan synthase, beta chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 PIRSF PIRSF001413 1 394 1.1E-163 T 21-04-2016 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 Gene3D G3DSA:3.40.50.1100 101 175 1.2E-20 T 21-04-2016 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 TIGRFAM TIGR00263 trpB: tryptophan synthase, beta subunit 10 390 1.1E-177 T 21-04-2016 IPR006654 Tryptophan synthase, beta chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15435 61ef512ff9805387d3df784c8cafcb2e 394 Gene3D G3DSA:3.40.50.1100 176 393 2.6E-86 T 21-04-2016 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Gene3D G3DSA:3.10.196.10 962 1230 8.3E-109 T 21-04-2016 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|UniPathway: UPA00051 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 TIGRFAM TIGR02082 metH: methionine synthase 7 1198 0.0 T 21-04-2016 IPR011822 Cobalamin-dependent methionine synthase GO:0008270|GO:0008705|GO:0008898|GO:0009086|GO:0031419 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|UniPathway: UPA00051 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 PANTHER PTHR21091:SF112 1 399 5.6E-165 T 21-04-2016 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 PIRSF PIRSF000381 1 1201 0.0 T 21-04-2016 IPR011822 Cobalamin-dependent methionine synthase GO:0008270|GO:0008705|GO:0008898|GO:0009086|GO:0031419 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|UniPathway: UPA00051 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 PANTHER PTHR21091 1 399 5.6E-165 T 21-04-2016 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 SUPERFAMILY SSF52242 746 898 1.07E-44 T 21-04-2016 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Pfam PF00809 Pterin binding enzyme 361 599 1.4E-59 T 21-04-2016 IPR000489 Pterin-binding domain GO:0042558 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Gene3D G3DSA:3.20.20.330 1 364 1.1E-124 T 21-04-2016 IPR003726 Homocysteine-binding domain SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 SUPERFAMILY SSF82282 2 400 1.7E-115 T 21-04-2016 IPR003726 Homocysteine-binding domain SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Pfam PF02310 B12 binding domain 752 842 3.7E-19 T 21-04-2016 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 SUPERFAMILY SSF51717 357 631 3.14E-87 T 21-04-2016 IPR011005 Dihydropteroate synthase-like GO:0044237 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain 943 1214 2.4E-125 T 21-04-2016 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|UniPathway: UPA00051 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Gene3D G3DSA:3.20.20.20 365 637 3.0E-113 T 21-04-2016 IPR000489 Pterin-binding domain GO:0042558 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 SUPERFAMILY SSF47644 651 737 4.05E-28 T 21-04-2016 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 SUPERFAMILY SSF56507 905 1230 1.44E-131 T 21-04-2016 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|UniPathway: UPA00051 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Pfam PF02607 B12 binding domain 657 730 3.5E-25 T 21-04-2016 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Gene3D G3DSA:1.10.1240.10 648 735 3.1E-37 T 21-04-2016 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 SMART SM01018 655 738 1.2E-43 T 21-04-2016 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Gene3D G3DSA:3.40.50.280 748 898 2.1E-61 T 21-04-2016 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 SPH21_RS01870 26f8ff1fedb2b4eba1de409608ae8f67 1230 Pfam PF02574 Homocysteine S-methyltransferase 12 324 3.1E-91 T 21-04-2016 IPR003726 Homocysteine-binding domain SPH21_RS08050 ab2778b665c01a7a189741bef82a4f60 309 Pfam PF00535 Glycosyl transferase family 2 11 132 2.9E-5 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS08050 ab2778b665c01a7a189741bef82a4f60 309 SUPERFAMILY SSF53448 7 228 1.1E-18 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08050 ab2778b665c01a7a189741bef82a4f60 309 Gene3D G3DSA:3.90.550.10 5 173 1.8E-10 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS18200 e61510a128c6a24e30030ed6fafa945f 281 SUPERFAMILY SSF52402 1 156 4.35E-17 T 21-04-2016 SPH21_RS18200 e61510a128c6a24e30030ed6fafa945f 281 Pfam PF00582 Universal stress protein family 2 148 3.1E-13 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS18200 e61510a128c6a24e30030ed6fafa945f 281 SUPERFAMILY SSF52402 156 279 1.76E-5 T 21-04-2016 SPH21_RS18200 e61510a128c6a24e30030ed6fafa945f 281 Gene3D G3DSA:3.40.50.620 2 148 2.0E-17 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 SUPERFAMILY SSF55190 6 94 1.62E-8 T 21-04-2016 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 SUPERFAMILY SSF47323 467 589 1.37E-29 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PANTHER PTHR11956 223 589 1.2E-158 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PANTHER PTHR11956 1 205 1.2E-158 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 SMART SM01016 2 85 3.7E-4 T 21-04-2016 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 SUPERFAMILY SSF52374 107 465 7.42E-77 T 21-04-2016 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 SMART SM00836 473 589 3.1E-39 T 21-04-2016 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 Gene3D G3DSA:3.30.1360.70 8 101 6.3E-11 T 21-04-2016 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 Gene3D G3DSA:3.40.50.620 107 466 8.7E-91 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 Gene3D G3DSA:1.10.730.10 468 589 1.6E-33 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PANTHER PTHR11956:SF6 223 589 1.2E-158 T 21-04-2016 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PANTHER PTHR11956:SF6 1 205 1.2E-158 T 21-04-2016 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 Pfam PF03485 Arginyl tRNA synthetase N terminal domain 7 85 1.3E-4 T 21-04-2016 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 Hamap MF_00123 Arginine--tRNA ligase [argS]. 2 589 23.355 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 120 131 - T 21-04-2016 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 TIGRFAM TIGR00456 argS: arginine--tRNA ligase 20 589 5.0E-130 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 Pfam PF00750 tRNA synthetases class I (R) 108 448 3.9E-44 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 Pfam PF05746 DALR anticodon binding domain 473 589 1.8E-32 T 21-04-2016 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PRINTS PR01038 Arginyl-tRNA synthetase signature 151 164 2.0E-17 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PRINTS PR01038 Arginyl-tRNA synthetase signature 112 127 2.0E-17 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PRINTS PR01038 Arginyl-tRNA synthetase signature 316 337 2.0E-17 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS14970 c8209449605e8092117a7686a86411b0 589 PRINTS PR01038 Arginyl-tRNA synthetase signature 127 143 2.0E-17 T 21-04-2016 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19|Reactome: REACT_71 SPH21_RS16520 e88676b56f6f7586a8a39cfc41943b77 187 SMART SM00342 100 174 1.8E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS16520 e88676b56f6f7586a8a39cfc41943b77 187 PANTHER PTHR11019:SF50 66 182 3.0E-21 T 21-04-2016 SPH21_RS16520 e88676b56f6f7586a8a39cfc41943b77 187 PANTHER PTHR11019 66 182 3.0E-21 T 21-04-2016 SPH21_RS16520 e88676b56f6f7586a8a39cfc41943b77 187 Pfam PF12833 Helix-turn-helix domain 99 174 2.4E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS16520 e88676b56f6f7586a8a39cfc41943b77 187 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 128 170 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS16520 e88676b56f6f7586a8a39cfc41943b77 187 SUPERFAMILY SSF46689 128 175 1.25E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16520 e88676b56f6f7586a8a39cfc41943b77 187 Gene3D G3DSA:1.10.10.60 127 175 3.6E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14280 9ec0ef0dc126f126d194e48bafe19d89 305 Gene3D G3DSA:2.60.120.280 46 177 9.7E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS14280 9ec0ef0dc126f126d194e48bafe19d89 305 Pfam PF12833 Helix-turn-helix domain 222 300 1.3E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS14280 9ec0ef0dc126f126d194e48bafe19d89 305 PANTHER PTHR11019:SF80 217 302 4.1E-21 T 21-04-2016 SPH21_RS14280 9ec0ef0dc126f126d194e48bafe19d89 305 PANTHER PTHR11019 217 302 4.1E-21 T 21-04-2016 SPH21_RS14280 9ec0ef0dc126f126d194e48bafe19d89 305 Gene3D G3DSA:1.10.10.60 254 302 3.7E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14280 9ec0ef0dc126f126d194e48bafe19d89 305 SMART SM00342 215 299 1.1E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS14280 9ec0ef0dc126f126d194e48bafe19d89 305 SUPERFAMILY SSF46689 255 303 7.62E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Gene3D G3DSA:2.170.130.10 128 239 2.3E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 SUPERFAMILY SSF49464 44 123 2.88E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Pfam PF13715 CarboxypepD_reg-like domain 46 125 2.1E-19 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 ProSitePatterns PS00018 EF-hand calcium-binding domain. 888 900 - T 21-04-2016 IPR018247 EF-Hand 1, calcium-binding site SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Pfam PF07715 TonB-dependent Receptor Plug Domain 134 239 5.4E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Gene3D G3DSA:2.40.170.20 981 1069 5.3E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Gene3D G3DSA:2.40.170.20 240 267 5.3E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Gene3D G3DSA:2.40.170.20 907 932 5.3E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Gene3D G3DSA:2.40.170.20 358 827 5.3E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 215 245 3.1E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 44 1069 2.1E-273 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 PANTHER PTHR11532 880 1067 3.8E-255 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 PANTHER PTHR11532 26 456 3.8E-255 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 PANTHER PTHR11532 551 864 3.8E-255 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 PANTHER PTHR11532:SF57 880 1067 3.8E-255 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 PANTHER PTHR11532:SF57 26 456 3.8E-255 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 PANTHER PTHR11532:SF57 551 864 3.8E-255 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 Gene3D G3DSA:2.60.40.1120 45 127 1.4E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 SUPERFAMILY SSF56935 898 942 4.49E-95 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 SUPERFAMILY SSF56935 475 820 4.49E-95 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 SUPERFAMILY SSF56935 349 437 4.49E-95 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 SUPERFAMILY SSF56935 982 1069 4.49E-95 T 21-04-2016 SPH21_RS02365 7a39c5a59087113b6448f0c6f52bc881 1069 SUPERFAMILY SSF56935 121 263 4.49E-95 T 21-04-2016 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 Gene3D G3DSA:1.50.10.10 550 710 3.6E-5 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 394 963 3.5E-109 T 21-04-2016 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 PANTHER PTHR31151 534 965 3.9E-123 T 21-04-2016 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 PANTHER PTHR31151 357 491 3.9E-123 T 21-04-2016 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 89 248 9.9E-18 T 21-04-2016 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 Gene3D G3DSA:2.60.120.200 41 254 3.3E-18 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 Pfam PF07532 Bacterial Ig-like domain (group 4) 293 350 1.8E-4 T 21-04-2016 IPR011081 Bacterial Ig-related KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 PANTHER PTHR31151:SF0 534 965 3.9E-123 T 21-04-2016 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 PANTHER PTHR31151:SF0 357 491 3.9E-123 T 21-04-2016 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 SUPERFAMILY SSF49899 31 254 2.29E-23 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 SUPERFAMILY SSF48208 555 791 1.43E-11 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS04525 e4aba295b541927cef1b724026df1a4b 1022 SUPERFAMILY SSF48208 447 481 1.43E-11 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 ProSitePatterns PS00691 DNA photolyases class 1 signature 2. 326 345 - T 21-04-2016 IPR018394 Cryptochrome/DNA photolyase class 1, conserved site, C-terminal SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 PRINTS PR00147 DNA photolyase signature 365 379 8.2E-28 T 21-04-2016 IPR002081 Cryptochrome/DNA photolyase class 1 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 PRINTS PR00147 DNA photolyase signature 306 322 8.2E-28 T 21-04-2016 IPR002081 Cryptochrome/DNA photolyase class 1 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 PRINTS PR00147 DNA photolyase signature 326 344 8.2E-28 T 21-04-2016 IPR002081 Cryptochrome/DNA photolyase class 1 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 PRINTS PR00147 DNA photolyase signature 145 161 8.2E-28 T 21-04-2016 IPR002081 Cryptochrome/DNA photolyase class 1 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 PANTHER PTHR11455 9 434 6.9E-162 T 21-04-2016 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 SUPERFAMILY SSF52425 4 185 3.14E-51 T 21-04-2016 IPR006050 DNA photolyase, N-terminal SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 Pfam PF03441 FAD binding domain of DNA photolyase 257 432 6.9E-73 T 21-04-2016 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 Pfam PF00875 DNA photolyase 9 165 8.9E-44 T 21-04-2016 IPR006050 DNA photolyase, N-terminal SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 Gene3D G3DSA:3.40.50.620 4 148 7.8E-47 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 SUPERFAMILY SSF48173 212 434 5.1E-89 T 21-04-2016 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 ProSitePatterns PS00394 DNA photolyases class 1 signature 1. 306 318 - T 21-04-2016 IPR018394 Cryptochrome/DNA photolyase class 1, conserved site, C-terminal SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 PANTHER PTHR11455:SF18 9 434 6.9E-162 T 21-04-2016 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 Gene3D G3DSA:1.10.579.10 266 434 9.1E-67 T 21-04-2016 SPH21_RS08315 7f4a2b029a5f1451eee7220c9b55ca3e 437 Gene3D G3DSA:1.25.40.80 149 265 4.5E-28 T 21-04-2016 SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 Gene3D G3DSA:3.40.640.10 37 284 4.7E-87 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 Pfam PF00266 Aminotransferase class-V 26 395 5.6E-150 T 21-04-2016 IPR000192 Aminotransferase class V domain SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 PANTHER PTHR11601 7 406 1.1E-192 T 21-04-2016 SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 Gene3D G3DSA:3.90.1150.10 285 401 1.5E-26 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 PIRSF PIRSF005572 23 406 9.1E-52 T 21-04-2016 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 ProSitePatterns PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218 237 - T 21-04-2016 IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 SUPERFAMILY SSF53383 4 402 2.42E-130 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 PANTHER PTHR11601:SF17 7 406 1.1E-192 T 21-04-2016 SPH21_RS19920 78aa607f53a2e837389506e5a859002b 407 TIGRFAM TIGR01979 sufS: cysteine desulfurase, SufS family 8 405 8.4E-182 T 21-04-2016 IPR010970 Cysteine desulfurase, SufS GO:0006534|GO:0030170|GO:0031071 KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 SPH21_RS24960 85a3f8e4d58ada77b0ebfdd16f67c731 97 Gene3D G3DSA:3.40.430.10 3 91 5.6E-5 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS24960 85a3f8e4d58ada77b0ebfdd16f67c731 97 SUPERFAMILY SSF53597 1 91 8.51E-7 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 Gene3D G3DSA:2.60.120.10 135 266 1.1E-24 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 SMART SM00448 2 115 5.5E-39 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 SMART SM00419 290 338 2.5E-7 T 21-04-2016 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 Pfam PF00072 Response regulator receiver domain 4 116 9.0E-28 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 Pfam PF13545 Crp-like helix-turn-helix domain 273 343 1.0E-12 T 21-04-2016 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 SUPERFAMILY SSF51206 142 268 3.93E-28 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 PANTHER PTHR26402 2 126 2.4E-40 T 21-04-2016 SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 Gene3D G3DSA:3.40.50.2300 2 127 2.0E-38 T 21-04-2016 SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 Gene3D G3DSA:1.10.10.10 269 345 4.9E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 SMART SM00100 130 255 8.5E-7 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 Pfam PF00027 Cyclic nucleotide-binding domain 153 239 9.5E-16 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 SUPERFAMILY SSF46785 270 344 8.71E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17525 662bfcd2639ab31f1d0fa1bc9edb91b3 347 SUPERFAMILY SSF52172 1 133 1.71E-38 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS05150 d31fa73d277936dc20839432671270dc 327 PANTHER PTHR10366:SF399 5 309 6.6E-123 T 21-04-2016 SPH21_RS05150 d31fa73d277936dc20839432671270dc 327 Pfam PF16363 GDP-mannose 4,6 dehydratase 7 304 1.4E-49 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05150 d31fa73d277936dc20839432671270dc 327 PANTHER PTHR10366 5 309 6.6E-123 T 21-04-2016 SPH21_RS05150 d31fa73d277936dc20839432671270dc 327 Gene3D G3DSA:3.40.50.720 2 173 9.3E-51 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05150 d31fa73d277936dc20839432671270dc 327 Gene3D G3DSA:3.90.25.10 174 313 5.0E-52 T 21-04-2016 SPH21_RS05150 d31fa73d277936dc20839432671270dc 327 SUPERFAMILY SSF51735 1 324 2.48E-86 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20795 468fe0123ffe04fae2fab26953e22fe7 115 SUPERFAMILY SSF46785 16 109 2.61E-25 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20795 468fe0123ffe04fae2fab26953e22fe7 115 Gene3D G3DSA:1.10.10.10 11 110 1.2E-32 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20795 468fe0123ffe04fae2fab26953e22fe7 115 PANTHER PTHR33204 1 109 1.4E-30 T 21-04-2016 SPH21_RS20795 468fe0123ffe04fae2fab26953e22fe7 115 Pfam PF01638 HxlR-like helix-turn-helix 23 109 7.4E-28 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS19535 01fdf05520c6b9ee877b8e345537ac10 142 ProSitePatterns PS00141 Eukaryotic and viral aspartyl proteases active site. 31 42 - T 21-04-2016 IPR001969 Aspartic peptidase, active site GO:0004190|GO:0006508 SPH21_RS19535 01fdf05520c6b9ee877b8e345537ac10 142 Pfam PF13650 Aspartyl protease 20 118 5.3E-11 T 21-04-2016 SPH21_RS19535 01fdf05520c6b9ee877b8e345537ac10 142 SUPERFAMILY SSF50630 17 130 2.94E-8 T 21-04-2016 IPR021109 Aspartic peptidase domain SPH21_RS21500 3bf9e5ed0b0646b3c9d9a5dfec26baba 238 Gene3D G3DSA:3.40.50.80 116 236 9.3E-5 T 21-04-2016 SPH21_RS21500 3bf9e5ed0b0646b3c9d9a5dfec26baba 238 Pfam PF00970 Oxidoreductase FAD-binding domain 23 109 5.8E-5 T 21-04-2016 IPR008333 Oxidoreductase, FAD-binding domain SPH21_RS21500 3bf9e5ed0b0646b3c9d9a5dfec26baba 238 SUPERFAMILY SSF63380 19 115 4.12E-10 T 21-04-2016 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SPH21_RS21500 3bf9e5ed0b0646b3c9d9a5dfec26baba 238 Gene3D G3DSA:2.40.30.10 21 109 1.5E-8 T 21-04-2016 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 PANTHER PTHR23083 308 545 6.0E-56 T 21-04-2016 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 PANTHER PTHR23083 28 235 6.0E-56 T 21-04-2016 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 Pfam PF13432 Tetratricopeptide repeat 491 542 0.0012 T 21-04-2016 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 Pfam PF13432 Tetratricopeptide repeat 37 99 2.5E-4 T 21-04-2016 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 Gene3D G3DSA:1.25.40.10 304 546 3.5E-38 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 Pfam PF14559 Tetratricopeptide repeat 179 243 5.9E-8 T 21-04-2016 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SUPERFAMILY SSF48452 32 262 6.2E-22 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 Gene3D G3DSA:1.25.40.10 32 264 4.3E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SUPERFAMILY SSF48452 303 405 1.06E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 66 99 28.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 342 375 370.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 32 65 84.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 519 552 450.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 134 167 140.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 415 448 0.0076 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 484 517 120.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 376 409 30.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 308 341 3.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SMART SM00028 202 235 0.18 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 Pfam PF13181 Tetratricopeptide repeat 308 338 0.0024 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 Pfam PF13181 Tetratricopeptide repeat 416 448 0.018 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS26095 7a427bf3d93ef750d65231a6791d3c9d 570 SUPERFAMILY SSF48452 373 546 1.21E-24 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 Gene3D G3DSA:2.60.40.1120 25 115 4.0E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 Pfam PF00593 TonB dependent receptor 548 795 4.1E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 SUPERFAMILY SSF56935 101 796 1.83E-101 T 21-04-2016 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 ProSitePatterns PS01156 TonB-dependent receptor proteins signature 2. 779 796 - T 21-04-2016 IPR010917 TonB-dependent receptor, conserved site SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 PANTHER PTHR32552:SF10 103 796 6.3E-96 T 21-04-2016 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 SUPERFAMILY SSF49464 23 108 2.35E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 PANTHER PTHR32552 103 796 6.3E-96 T 21-04-2016 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 Pfam PF07715 TonB-dependent Receptor Plug Domain 133 231 9.1E-6 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 Pfam PF13715 CarboxypepD_reg-like domain 25 110 1.8E-16 T 21-04-2016 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 Gene3D G3DSA:2.40.170.20 246 796 9.6E-112 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 Gene3D G3DSA:2.170.130.10 116 239 1.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05820 dd6089d546003ed4983bda8ead78a1e4 796 TIGRFAM TIGR01783 TonB-siderophor: TonB-dependent siderophore receptor 134 796 5.5E-82 T 21-04-2016 IPR010105 TonB-dependent siderophore receptor GO:0004872|GO:0005506|GO:0015891 SPH21_RS08710 ab7d79ce148f85b3eb45c345602d63f8 530 Pfam PF07690 Major Facilitator Superfamily 23 415 2.2E-11 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS08710 ab7d79ce148f85b3eb45c345602d63f8 530 SUPERFAMILY SSF103473 490 515 3.4E-22 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS08710 ab7d79ce148f85b3eb45c345602d63f8 530 SUPERFAMILY SSF103473 13 207 3.4E-22 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS08710 ab7d79ce148f85b3eb45c345602d63f8 530 SUPERFAMILY SSF103473 256 426 3.4E-22 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS08710 ab7d79ce148f85b3eb45c345602d63f8 530 Gene3D G3DSA:1.20.1250.20 13 193 3.7E-9 T 21-04-2016 SPH21_RS08710 ab7d79ce148f85b3eb45c345602d63f8 530 PANTHER PTHR23501 10 511 1.1E-18 T 21-04-2016 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PIRSF PIRSF000114 3 327 4.8E-69 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 Gene3D G3DSA:1.10.1040.10 185 324 1.5E-35 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 238 255 1.7E-21 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 57 84 1.7E-21 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 174 198 1.7E-21 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 134 154 1.7E-21 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 6 23 1.7E-21 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 199 223 1.7E-21 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 SUPERFAMILY SSF51735 4 179 2.17E-24 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 SUPERFAMILY SSF48179 181 324 2.21E-32 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 Gene3D G3DSA:3.40.50.720 5 184 1.7E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 Pfam PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 5 159 2.8E-24 T 21-04-2016 IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal GO:0016616|GO:0046168|GO:0051287|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PANTHER PTHR11728 6 323 8.7E-66 T 21-04-2016 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 Pfam PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 181 316 2.1E-37 T 21-04-2016 IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal GO:0004367|GO:0005975|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS12900 4704d11efaec3fc2d36c6bc4bd0b0143 328 PANTHER PTHR11728:SF1 6 323 8.7E-66 T 21-04-2016 SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 Pfam PF12836 Helix-hairpin-helix motif 323 365 5.8E-7 T 21-04-2016 SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 Gene3D G3DSA:3.20.20.70 43 243 4.2E-11 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 PANTHER PTHR21180 132 376 1.2E-122 T 21-04-2016 SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 PANTHER PTHR21180:SF9 132 376 1.2E-122 T 21-04-2016 IPR023874 DNA modification/repair radical SAM protein, putative SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 TIGRFAM TIGR03916 rSAM_link_UDG: putative DNA modification/repair radical SAM protein 4 416 1.7E-200 T 21-04-2016 IPR023874 DNA modification/repair radical SAM protein, putative SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 SUPERFAMILY SSF102114 42 259 1.57E-15 T 21-04-2016 SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 Gene3D G3DSA:1.10.150.320 324 365 1.2E-4 T 21-04-2016 SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 SUPERFAMILY SSF47781 304 379 6.23E-13 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS20170 8f0c5053fe710476f0bddf39fc51c66f 416 SMART SM00729 54 281 0.0086 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS08535 93e0ee452de97800b97a12451377c285 76 ProSitePatterns PS00579 Ribosomal protein L29 signature. 39 53 - T 21-04-2016 IPR018254 Ribosomal protein L29, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08535 93e0ee452de97800b97a12451377c285 76 Pfam PF00831 Ribosomal L29 protein 4 58 2.9E-16 T 21-04-2016 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08535 93e0ee452de97800b97a12451377c285 76 SUPERFAMILY SSF46561 1 59 9.42E-15 T 21-04-2016 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08535 93e0ee452de97800b97a12451377c285 76 Gene3D G3DSA:1.10.287.310 1 59 3.2E-15 T 21-04-2016 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08535 93e0ee452de97800b97a12451377c285 76 Hamap MF_00374 50S ribosomal protein L29 [rpmC]. 1 60 14.284 T 21-04-2016 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08535 93e0ee452de97800b97a12451377c285 76 TIGRFAM TIGR00012 L29: ribosomal protein uL29 5 58 8.7E-13 T 21-04-2016 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 PANTHER PTHR11785:SF405 192 444 4.2E-136 T 21-04-2016 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 PANTHER PTHR11785:SF405 507 559 4.2E-136 T 21-04-2016 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 PANTHER PTHR11785:SF405 26 140 4.2E-136 T 21-04-2016 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 PANTHER PTHR11785 192 444 4.2E-136 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 PANTHER PTHR11785 507 559 4.2E-136 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 PANTHER PTHR11785 26 140 4.2E-136 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 PIRSF PIRSF006060 11 563 1.8E-72 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 Pfam PF13906 C-terminus of AA_permease 514 556 9.7E-13 T 21-04-2016 IPR029485 Cationic amino acid transporter, C-terminal SPH21_RS19410 0f29dbd0e2c46f2dc3f49622cf413731 564 Pfam PF13520 Amino acid permease 31 467 4.5E-53 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 SUPERFAMILY SSF53155 185 266 3.34E-12 T 21-04-2016 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 SMART SM00342 98 176 4.0E-11 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 Pfam PF12833 Helix-turn-helix domain 104 174 6.4E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 PANTHER PTHR10815 153 342 9.1E-60 T 21-04-2016 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 Gene3D G3DSA:1.10.10.60 131 176 8.3E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 263 342 5.0E-31 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 PANTHER PTHR10815:SF5 153 342 9.1E-60 T 21-04-2016 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 ProSitePatterns PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 313 319 - T 21-04-2016 IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site GO:0003908|GO:0006281 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 SUPERFAMILY SSF57884 2 75 1.7E-31 T 21-04-2016 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 SUPERFAMILY SSF46689 131 179 3.05E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 Gene3D G3DSA:1.10.10.10 262 343 7.6E-31 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 Gene3D G3DSA:3.30.160.70 177 258 1.5E-4 T 21-04-2016 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 SUPERFAMILY SSF46767 262 343 2.88E-28 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 Gene3D G3DSA:3.40.10.10 3 75 1.2E-31 T 21-04-2016 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 Pfam PF02805 Metal binding domain of Ada 8 70 2.3E-29 T 21-04-2016 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 265 343 8.5E-29 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS21155 13c82dd432497230c7c904b3bf600872 348 PIRSF PIRSF000409 1 348 1.9E-134 T 21-04-2016 IPR016221 Bifunctional regulatory protein Ada SPH21_RS10475 9b23ae8dfb20b928fb3351011548105a 59 SUPERFAMILY SSF50249 1 58 5.63E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS10475 9b23ae8dfb20b928fb3351011548105a 59 Gene3D G3DSA:2.40.50.140 2 59 2.2E-18 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS10475 9b23ae8dfb20b928fb3351011548105a 59 PIRSF PIRSF002599 1 59 7.6E-12 T 21-04-2016 IPR012156 Cold shock, CspA GO:0003676 SPH21_RS10475 9b23ae8dfb20b928fb3351011548105a 59 Pfam PF00313 'Cold-shock' DNA-binding domain 1 58 6.8E-15 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS10475 9b23ae8dfb20b928fb3351011548105a 59 SMART SM00357 1 59 5.7E-9 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 Gene3D G3DSA:3.60.15.10 114 240 6.8E-5 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 Pfam PF00753 Metallo-beta-lactamase superfamily 79 126 1.1E-4 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 SUPERFAMILY SSF56281 282 330 1.44E-16 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 SUPERFAMILY SSF56281 79 241 1.44E-16 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 PANTHER PTHR30619 265 327 7.1E-20 T 21-04-2016 SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 PANTHER PTHR30619 182 243 7.1E-20 T 21-04-2016 SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 PANTHER PTHR30619 85 154 7.1E-20 T 21-04-2016 SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 PANTHER PTHR30619 1 55 7.1E-20 T 21-04-2016 SPH21_RS21750 3dd84a93c989f1c121cb13868794c568 444 Gene3D G3DSA:3.60.15.10 69 113 6.0E-8 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Pfam PF00012 Hsp70 protein 4 599 4.3E-261 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1. 7 14 - T 21-04-2016 IPR018181 Heat shock protein 70, conserved site SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Hamap MF_00332 Chaperone protein DnaK [dnaK]. 1 632 37.515 T 21-04-2016 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:3.90.640.10 224 310 2.6E-29 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:1.20.1270.10 527 598 8.0E-21 T 21-04-2016 IPR029048 Heat shock protein 70kD, C-terminal domain SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 ProSitePatterns PS01036 Heat shock hsp70 proteins family signature 3. 332 346 - T 21-04-2016 IPR018181 Heat shock protein 70, conserved site SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:3.30.420.40 190 223 1.1E-35 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:3.30.420.40 314 356 1.1E-35 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 SUPERFAMILY SSF100920 379 535 8.63E-61 T 21-04-2016 IPR029047 Heat shock protein 70kD, peptide-binding domain SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:2.60.34.10 385 526 2.7E-70 T 21-04-2016 IPR029047 Heat shock protein 70kD, peptide-binding domain SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 SUPERFAMILY SSF100934 502 607 2.16E-12 T 21-04-2016 IPR029048 Heat shock protein 70kD, C-terminal domain SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PANTHER PTHR19375:SF173 2 638 0.0 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 136 156 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 196 206 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 54 62 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 383 402 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 329 345 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 3 16 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 31 43 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 464 480 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PRINTS PR00301 70kDa heat shock protein signature 360 380 2.4E-78 T 21-04-2016 IPR013126 Heat shock protein 70 family SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:3.30.30.30 53 103 5.0E-21 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 SUPERFAMILY SSF53067 1 181 4.66E-64 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:3.30.420.40 117 189 1.4E-61 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 Gene3D G3DSA:3.30.420.40 4 52 1.4E-61 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 TIGRFAM TIGR02350 prok_dnaK: chaperone protein DnaK 3 598 1.4E-300 T 21-04-2016 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 PANTHER PTHR19375 2 638 0.0 T 21-04-2016 SPH21_RS08640 f4088cecff13963be6859eacd1b4f97f 638 SUPERFAMILY SSF53067 185 377 7.13E-66 T 21-04-2016 SPH21_RS05710 6463fc5cf0f6411adade745a25cc7222 200 PANTHER PTHR30506 2 198 6.0E-59 T 21-04-2016 SPH21_RS05710 6463fc5cf0f6411adade745a25cc7222 200 PANTHER PTHR30506:SF3 2 198 6.0E-59 T 21-04-2016 SPH21_RS05710 6463fc5cf0f6411adade745a25cc7222 200 Pfam PF03458 UPF0126 domain 7 79 5.9E-20 T 21-04-2016 IPR005115 Uncharacterised domain UPF0126 SPH21_RS05710 6463fc5cf0f6411adade745a25cc7222 200 Pfam PF03458 UPF0126 domain 91 163 1.4E-18 T 21-04-2016 IPR005115 Uncharacterised domain UPF0126 SPH21_RS03665 09394c1f5b047db1dff31fd51354d982 375 Pfam PF14289 Domain of unknown function (DUF4369) 16 119 2.2E-20 T 21-04-2016 IPR025380 Domain of unknown function DUF4369 SPH21_RS03665 09394c1f5b047db1dff31fd51354d982 375 Gene3D G3DSA:3.40.30.10 233 372 8.0E-54 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS03665 09394c1f5b047db1dff31fd51354d982 375 PANTHER PTHR13871 246 362 2.3E-28 T 21-04-2016 SPH21_RS03665 09394c1f5b047db1dff31fd51354d982 375 SUPERFAMILY SSF52833 236 373 5.28E-35 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS03665 09394c1f5b047db1dff31fd51354d982 375 ProSitePatterns PS00194 Thioredoxin family active site. 265 283 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS03665 09394c1f5b047db1dff31fd51354d982 375 Pfam PF00578 AhpC/TSA family 237 357 4.1E-27 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS07715 4a50627db227d1b2456fa970ce2fb413 229 PANTHER PTHR11403 30 229 1.9E-38 T 21-04-2016 IPR024791 Cytochrome c oxidase subunit III GO:0015002|GO:0016020|GO:0019646 SPH21_RS07715 4a50627db227d1b2456fa970ce2fb413 229 SUPERFAMILY SSF81452 16 228 1.2E-43 T 21-04-2016 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 SPH21_RS07715 4a50627db227d1b2456fa970ce2fb413 229 Pfam PF00510 Cytochrome c oxidase subunit III 13 228 1.1E-10 T 21-04-2016 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 SPH21_RS07715 4a50627db227d1b2456fa970ce2fb413 229 Gene3D G3DSA:1.20.120.80 24 229 5.8E-54 T 21-04-2016 IPR013833 Cytochrome c oxidase, subunit III, 4-helical bundle GO:0004129|GO:0016020|GO:0022904 SPH21_RS13740 d873abbe5acd5aab45cad201157ec345 299 Gene3D G3DSA:3.40.800.10 2 289 2.6E-42 T 21-04-2016 IPR023696 Ureohydrolase domain SPH21_RS13740 d873abbe5acd5aab45cad201157ec345 299 PANTHER PTHR11358 65 280 2.3E-20 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS13740 d873abbe5acd5aab45cad201157ec345 299 PRINTS PR00116 Arginase signature 221 250 1.8E-5 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS13740 d873abbe5acd5aab45cad201157ec345 299 PRINTS PR00116 Arginase signature 95 110 1.8E-5 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS13740 d873abbe5acd5aab45cad201157ec345 299 SUPERFAMILY SSF52768 3 290 7.74E-45 T 21-04-2016 SPH21_RS13740 d873abbe5acd5aab45cad201157ec345 299 Pfam PF00491 Arginase family 79 287 4.7E-23 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS14330 1833cff15975da30f683d6c817b709ca 826 SUPERFAMILY SSF48208 281 765 1.12E-91 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS14330 1833cff15975da30f683d6c817b709ca 826 PANTHER PTHR31084 1 804 0.0 T 21-04-2016 SPH21_RS14330 1833cff15975da30f683d6c817b709ca 826 PIRSF PIRSF007663 17 794 8.0E-288 T 21-04-2016 IPR016518 Alpha-L-fucosidase GO:0004560 KEGG: 00511+3.2.1.51 SPH21_RS14330 1833cff15975da30f683d6c817b709ca 826 PANTHER PTHR31084:SF4 1 804 0.0 T 21-04-2016 SPH21_RS14330 1833cff15975da30f683d6c817b709ca 826 Gene3D G3DSA:2.70.98.50 34 410 2.3E-142 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS14330 1833cff15975da30f683d6c817b709ca 826 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 35 275 2.9E-71 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS23280 28003fae5f8a11c6d48759aa3e199df7 448 Gene3D G3DSA:1.25.40.10 201 399 1.1E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23280 28003fae5f8a11c6d48759aa3e199df7 448 Pfam PF07980 SusD family 283 448 8.5E-28 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23280 28003fae5f8a11c6d48759aa3e199df7 448 SUPERFAMILY SSF48452 22 448 5.69E-106 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23280 28003fae5f8a11c6d48759aa3e199df7 448 Pfam PF14322 Starch-binding associating with outer membrane 25 222 8.1E-32 T 21-04-2016 SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 172 1.0E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 1.0E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 1.0E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 258 2.4E-49 T 21-04-2016 SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 SUPERFAMILY SSF51735 10 257 4.91E-70 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 140 168 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 2.5E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 153 172 2.5E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 221 241 2.5E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 2.5E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 191 2.5E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 2.5E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PANTHER PTHR24322 153 184 2.3E-42 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 PANTHER PTHR24322 15 136 2.3E-42 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21630 eac07230259c69eda8f3b009cd9b7607 261 Gene3D G3DSA:3.40.50.720 6 257 8.2E-71 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 Gene3D G3DSA:1.10.10.10 515 609 1.2E-7 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 Gene3D G3DSA:1.25.40.10 302 371 2.8E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 Gene3D G3DSA:1.25.40.10 60 206 2.8E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 Pfam PF00196 Bacterial regulatory proteins, luxR family 555 600 4.3E-6 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 SUPERFAMILY SSF46894 548 613 8.84E-9 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 SMART SM00421 552 609 0.005 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 ProSitePatterns PS00622 LuxR-type HTH domain signature. 569 596 - T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS12905 3a9af46f900b9c4aa7e5a16481b175a0 616 SUPERFAMILY SSF48452 60 201 1.77E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04855 f08e5d3c097bc39856ce0056749d72bf 495 PANTHER PTHR11699 1 486 1.1E-103 T 21-04-2016 SPH21_RS04855 f08e5d3c097bc39856ce0056749d72bf 495 PANTHER PTHR11699:SF10 1 486 1.1E-103 T 21-04-2016 SPH21_RS04855 f08e5d3c097bc39856ce0056749d72bf 495 Gene3D G3DSA:3.40.309.10 233 421 1.9E-43 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS04855 f08e5d3c097bc39856ce0056749d72bf 495 SUPERFAMILY SSF53720 4 484 9.56E-82 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS04855 f08e5d3c097bc39856ce0056749d72bf 495 Gene3D G3DSA:3.40.605.10 3 232 2.3E-34 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS04855 f08e5d3c097bc39856ce0056749d72bf 495 Pfam PF00171 Aldehyde dehydrogenase family 5 423 1.2E-33 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS08590 4039e2b2d239558dfbfbc1eb990b56c5 148 Pfam PF00828 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A 27 146 5.5E-36 T 21-04-2016 IPR021131 Ribosomal protein L18e/L15P SPH21_RS08590 4039e2b2d239558dfbfbc1eb990b56c5 148 TIGRFAM TIGR01071 rplO_bact: ribosomal protein uL15 2 145 3.6E-48 T 21-04-2016 IPR005749 Ribosomal protein L15, bacterial-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS08590 4039e2b2d239558dfbfbc1eb990b56c5 148 Gene3D G3DSA:3.100.10.10 32 147 3.0E-33 T 21-04-2016 SPH21_RS08590 4039e2b2d239558dfbfbc1eb990b56c5 148 ProSitePatterns PS00475 Ribosomal protein L15 signature. 112 142 - T 21-04-2016 IPR001196 Ribosomal protein L15, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08590 4039e2b2d239558dfbfbc1eb990b56c5 148 Hamap MF_01341 50S ribosomal protein L15 [rplO]. 3 148 21.116 T 21-04-2016 IPR030878 Ribosomal protein L15 GO:0003735|GO:0006412|GO:0015934 SPH21_RS08590 4039e2b2d239558dfbfbc1eb990b56c5 148 SUPERFAMILY SSF52080 5 146 2.22E-45 T 21-04-2016 IPR021131 Ribosomal protein L18e/L15P SPH21_RS08590 4039e2b2d239558dfbfbc1eb990b56c5 148 PANTHER PTHR12934 1 145 3.9E-59 T 21-04-2016 IPR005749 Ribosomal protein L15, bacterial-type GO:0003735|GO:0006412|GO:0015934 SPH21_RS03315 4cedb013b43a9652e1da7d59af4fa99b 363 Gene3D G3DSA:2.130.10.10 167 351 7.9E-11 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS03315 4cedb013b43a9652e1da7d59af4fa99b 363 SUPERFAMILY SSF50969 135 356 2.2E-19 T 21-04-2016 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like SPH21_RS03315 4cedb013b43a9652e1da7d59af4fa99b 363 Pfam PF05096 Glutamine cyclotransferase 118 360 2.7E-96 T 21-04-2016 IPR007788 Glutamine cyclotransferase SPH21_RS03315 4cedb013b43a9652e1da7d59af4fa99b 363 PANTHER PTHR31270 122 361 6.0E-91 T 21-04-2016 SPH21_RS03315 4cedb013b43a9652e1da7d59af4fa99b 363 PANTHER PTHR31270:SF0 122 361 6.0E-91 T 21-04-2016 SPH21_RS07375 d405131b429cda90bdf05526efdc3e47 184 Pfam PF03352 Methyladenine glycosylase 7 183 1.2E-77 T 21-04-2016 IPR005019 Methyladenine glycosylase GO:0006284|GO:0008725 SPH21_RS07375 d405131b429cda90bdf05526efdc3e47 184 PANTHER PTHR30037:SF4 1 183 3.0E-101 T 21-04-2016 SPH21_RS07375 d405131b429cda90bdf05526efdc3e47 184 Gene3D G3DSA:1.10.340.30 3 183 4.1E-80 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS07375 d405131b429cda90bdf05526efdc3e47 184 SUPERFAMILY SSF48150 3 183 6.98E-74 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS07375 d405131b429cda90bdf05526efdc3e47 184 PANTHER PTHR30037 1 183 3.0E-101 T 21-04-2016 SPH21_RS20120 46b4050aea486bc09e654452fa11f3e7 860 SUPERFAMILY SSF55729 659 838 8.48E-8 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS20120 46b4050aea486bc09e654452fa11f3e7 860 PANTHER PTHR34697:SF2 255 478 2.6E-98 T 21-04-2016 SPH21_RS20120 46b4050aea486bc09e654452fa11f3e7 860 PANTHER PTHR34697:SF2 496 860 2.6E-98 T 21-04-2016 SPH21_RS20120 46b4050aea486bc09e654452fa11f3e7 860 PANTHER PTHR34697 255 478 2.6E-98 T 21-04-2016 SPH21_RS20120 46b4050aea486bc09e654452fa11f3e7 860 PANTHER PTHR34697 496 860 2.6E-98 T 21-04-2016 SPH21_RS20120 46b4050aea486bc09e654452fa11f3e7 860 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 18 311 3.2E-24 T 21-04-2016 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SPH21_RS20120 46b4050aea486bc09e654452fa11f3e7 860 Pfam PF09924 Uncharacterised conserved protein (DUF2156) 548 841 5.1E-62 T 21-04-2016 IPR024320 Phosphatidylglycerol lysyltransferase, C-terminal SPH21_RS01600 4a326ad284cba6900384254652d08390 52 ProSitePatterns PS00784 Ribosomal protein L34 signature. 2 21 - T 21-04-2016 IPR020939 Ribosomal protein L34, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS01600 4a326ad284cba6900384254652d08390 52 Hamap MF_00391 50S ribosomal protein L34 [rpmH]. 1 44 15.966 T 21-04-2016 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS01600 4a326ad284cba6900384254652d08390 52 TIGRFAM TIGR01030 rpmH_bact: ribosomal protein bL34 1 44 9.6E-23 T 21-04-2016 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS01600 4a326ad284cba6900384254652d08390 52 Pfam PF00468 Ribosomal protein L34 1 44 3.6E-23 T 21-04-2016 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS01600 4a326ad284cba6900384254652d08390 52 PANTHER PTHR14503 1 46 2.6E-23 T 21-04-2016 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS01600 4a326ad284cba6900384254652d08390 52 ProDom PD003101 RIBOSOMAL L34 RIBONUCLEOPROTEIN 50S CHLOROPLAST PLASTID L34 MITOCHONDRIAL PEPTIDE SEQUENCING 1 42 5.0E-15 T 21-04-2016 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 ProSitePatterns PS00039 DEAD-box subfamily ATP-dependent helicases signature. 153 161 - T 21-04-2016 IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 SMART SM00490 257 338 5.7E-31 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 Gene3D G3DSA:3.40.50.300 219 373 2.2E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 PANTHER PTHR24031 3 407 1.2E-166 T 21-04-2016 SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 Pfam PF00271 Helicase conserved C-terminal domain 230 337 1.6E-29 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 Gene3D G3DSA:3.40.50.300 2 218 5.0E-77 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 SUPERFAMILY SSF52540 72 359 8.18E-74 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 SMART SM00487 20 221 4.7E-62 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS17505 a8b72f81bdb70bbd761bd0c0f9ae70cb 420 Pfam PF00270 DEAD/DEAH box helicase 25 193 8.7E-49 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS04370 8405c052fec286896306cbb970d05d13 444 Gene3D G3DSA:1.20.1600.10 31 442 1.9E-55 T 21-04-2016 SPH21_RS04370 8405c052fec286896306cbb970d05d13 444 Pfam PF02321 Outer membrane efflux protein 34 229 1.6E-22 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS04370 8405c052fec286896306cbb970d05d13 444 Pfam PF02321 Outer membrane efflux protein 258 442 5.5E-27 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS04370 8405c052fec286896306cbb970d05d13 444 SUPERFAMILY SSF56954 3 444 1.03E-63 T 21-04-2016 SPH21_RS04370 8405c052fec286896306cbb970d05d13 444 PANTHER PTHR30026 29 444 4.6E-42 T 21-04-2016 SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 SUPERFAMILY SSF55021 255 344 3.66E-19 T 21-04-2016 SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 Pfam PF00005 ABC transporter 21 169 4.4E-34 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 SMART SM00382 30 226 9.4E-16 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 Gene3D G3DSA:3.30.70.260 238 344 1.7E-24 T 21-04-2016 SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 Pfam PF09383 NIL domain 269 340 1.9E-17 T 21-04-2016 IPR018449 NIL domain SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 PANTHER PTHR24220:SF455 3 330 1.7E-158 T 21-04-2016 IPR026253 Methionine import ATP-binding protein MetN GO:0005524|GO:0015821|GO:0042626 SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 SUPERFAMILY SSF52540 1 240 6.46E-82 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 Gene3D G3DSA:3.40.50.300 1 237 3.6E-83 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 PANTHER PTHR24220 3 330 1.7E-158 T 21-04-2016 SPH21_RS22420 216eefece08583381c986f08d7f7b563 344 SMART SM00930 266 341 6.9E-19 T 21-04-2016 IPR018449 NIL domain SPH21_RS01970 ffeea892dfb125d1c9c9a25d8490659a 130 PANTHER PTHR10245 9 114 3.2E-19 T 21-04-2016 SPH21_RS01970 ffeea892dfb125d1c9c9a25d8490659a 130 Gene3D G3DSA:1.10.260.40 10 71 2.3E-14 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS01970 ffeea892dfb125d1c9c9a25d8490659a 130 Pfam PF01381 Helix-turn-helix 15 65 4.5E-10 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01970 ffeea892dfb125d1c9c9a25d8490659a 130 SUPERFAMILY SSF47413 4 69 1.3E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS01970 ffeea892dfb125d1c9c9a25d8490659a 130 SMART SM00530 13 67 5.0E-9 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01970 ffeea892dfb125d1c9c9a25d8490659a 130 PANTHER PTHR10245:SF58 9 114 3.2E-19 T 21-04-2016 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PANTHER PTHR11902 1 426 1.5E-276 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 Hamap MF_00318 Enolase [eno]. 2 415 44.663 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 SMART SM01192 139 429 3.2E-218 T 21-04-2016 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 Pfam PF00113 Enolase, C-terminal TIM barrel domain 141 427 1.1E-131 T 21-04-2016 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 ProSitePatterns PS00164 Enolase signature. 338 351 - T 21-04-2016 IPR020809 Enolase, conserved site KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 Pfam PF03952 Enolase, N-terminal domain 4 134 3.1E-63 T 21-04-2016 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PIRSF PIRSF001400 1 428 5.8E-193 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 SUPERFAMILY SSF51604 139 427 2.55E-129 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 Gene3D G3DSA:3.30.390.10 4 125 7.7E-60 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 SMART SM01193 4 134 1.4E-100 T 21-04-2016 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 TIGRFAM TIGR01060 eno: phosphopyruvate hydratase 4 425 8.8E-209 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 Gene3D G3DSA:3.20.20.120 129 426 2.1E-136 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PRINTS PR00148 Enolase signature 338 352 3.3E-49 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PRINTS PR00148 Enolase signature 107 123 3.3E-49 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PRINTS PR00148 Enolase signature 37 51 3.3E-49 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PRINTS PR00148 Enolase signature 367 384 3.3E-49 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PRINTS PR00148 Enolase signature 315 326 3.3E-49 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 PRINTS PR00148 Enolase signature 161 174 3.3E-49 T 21-04-2016 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS01635 1d65cddc702e2733326854c2f753fc8d 430 SUPERFAMILY SSF54826 3 138 1.77E-60 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS07510 657ba6a7e9ea51a45da7d47866124f3f 101 PIRSF PIRSF004555 1 101 4.0E-24 T 21-04-2016 IPR004401 Nucleoid-associated protein YbaB/EbfC family SPH21_RS07510 657ba6a7e9ea51a45da7d47866124f3f 101 PANTHER PTHR33449 1 101 1.8E-17 T 21-04-2016 SPH21_RS07510 657ba6a7e9ea51a45da7d47866124f3f 101 SUPERFAMILY SSF82607 3 91 1.57E-19 T 21-04-2016 IPR004401 Nucleoid-associated protein YbaB/EbfC family SPH21_RS07510 657ba6a7e9ea51a45da7d47866124f3f 101 Hamap MF_00274 Nucleoid-associated protein YbaB [ybaB]. 1 88 13.979 T 21-04-2016 IPR004401 Nucleoid-associated protein YbaB/EbfC family SPH21_RS07510 657ba6a7e9ea51a45da7d47866124f3f 101 Pfam PF02575 YbaB/EbfC DNA-binding family 5 91 2.5E-21 T 21-04-2016 IPR004401 Nucleoid-associated protein YbaB/EbfC family SPH21_RS07510 657ba6a7e9ea51a45da7d47866124f3f 101 Gene3D G3DSA:3.30.1310.10 1 98 2.3E-22 T 21-04-2016 IPR004401 Nucleoid-associated protein YbaB/EbfC family SPH21_RS26050 adce4b4d0981cabf27c5fc68a5cd9d3a 234 Pfam PF13559 Domain of unknown function (DUF4129) 161 220 3.0E-9 T 21-04-2016 IPR025403 Domain of unknown function DUF4129 SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PANTHER PTHR24322 11 140 3.7E-64 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PANTHER PTHR24322 156 188 3.7E-64 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 Gene3D G3DSA:3.40.50.720 2 246 1.1E-94 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 5.36E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 5.36E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 5.36E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 5.36E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 5.36E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 5.36E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 192 9.3E-5 T 21-04-2016 SPH21_RS01645 d681d8515fc559771506a474b2208652 247 TIGRFAM TIGR01830 3oxo_ACP_reduc: 3-oxoacyl-[acyl-carrier-protein] reductase 9 246 2.6E-104 T 21-04-2016 IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase GO:0004316|GO:0006633|GO:0051287|GO:0055114 KEGG: 00040+1.1.1.10|KEGG: 00061+1.1.1.100|KEGG: 00780+1.1.1.100|MetaCyc: PWY-5367|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321|UniPathway: UPA00094 SPH21_RS01645 d681d8515fc559771506a474b2208652 247 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 246 3.5E-75 T 21-04-2016 SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 4.13E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 4.13E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 4.13E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01645 d681d8515fc559771506a474b2208652 247 SUPERFAMILY SSF51735 5 246 8.25E-92 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PANTHER PTHR24322:SF328 11 140 3.7E-64 T 21-04-2016 SPH21_RS01645 d681d8515fc559771506a474b2208652 247 PANTHER PTHR24322:SF328 156 188 3.7E-64 T 21-04-2016 SPH21_RS01645 d681d8515fc559771506a474b2208652 247 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 Gene3D G3DSA:3.40.50.1820 13 277 2.2E-61 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 Pfam PF00561 alpha/beta hydrolase fold 27 264 5.4E-28 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PANTHER PTHR10992 19 278 3.7E-86 T 21-04-2016 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 SUPERFAMILY SSF53474 13 277 3.75E-60 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PRINTS PR00111 Alpha/beta hydrolase fold signature 96 109 7.6E-11 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PRINTS PR00111 Alpha/beta hydrolase fold signature 52 67 7.6E-11 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PRINTS PR00111 Alpha/beta hydrolase fold signature 221 235 7.6E-11 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PRINTS PR00412 Epoxide hydrolase signature 52 67 9.5E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PRINTS PR00412 Epoxide hydrolase signature 219 235 9.5E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PRINTS PR00412 Epoxide hydrolase signature 32 50 9.5E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS25835 faccd42b7845bb89fb3fb4ec2fbdca64 280 PANTHER PTHR10992:SF859 19 278 3.7E-86 T 21-04-2016 SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 SMART SM00345 27 86 8.1E-10 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 SUPERFAMILY SSF53383 133 491 2.56E-72 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 Gene3D G3DSA:1.10.10.10 15 87 1.8E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 PANTHER PTHR11751:SF294 112 493 1.3E-68 T 21-04-2016 SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 SUPERFAMILY SSF46785 16 89 1.03E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 Pfam PF00392 Bacterial regulatory proteins, gntR family 24 86 1.2E-10 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 PANTHER PTHR11751 112 493 1.3E-68 T 21-04-2016 SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 Gene3D G3DSA:3.40.640.10 164 385 2.5E-60 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS16490 61e9cb20162dfb9f9c27814e66e535a9 495 Pfam PF00155 Aminotransferase class I and II 168 485 7.7E-21 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 PANTHER PTHR11532:SF57 615 1086 5.6E-222 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 PANTHER PTHR11532:SF57 44 397 5.6E-222 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 PANTHER PTHR11532:SF57 498 581 5.6E-222 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 SUPERFAMILY SSF56935 916 961 2.79E-71 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 SUPERFAMILY SSF56935 126 267 2.79E-71 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 SUPERFAMILY SSF56935 455 834 2.79E-71 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 SUPERFAMILY SSF56935 318 406 2.79E-71 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 SUPERFAMILY SSF56935 1005 1088 2.79E-71 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 Gene3D G3DSA:2.60.40.1120 52 136 3.4E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 Gene3D G3DSA:2.170.130.10 137 246 3.0E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 Gene3D G3DSA:2.40.170.20 914 966 9.1E-16 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 Gene3D G3DSA:2.40.170.20 1013 1055 9.1E-16 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 Gene3D G3DSA:2.40.170.20 326 834 9.1E-16 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 Pfam PF13715 CarboxypepD_reg-like domain 53 132 3.7E-14 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 SUPERFAMILY SSF49464 50 130 1.57E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 Pfam PF07715 TonB-dependent Receptor Plug Domain 140 243 6.7E-14 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 220 249 2.1E-14 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 52 1088 5.5E-232 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 PANTHER PTHR11532 615 1086 5.6E-222 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 PANTHER PTHR11532 44 397 5.6E-222 T 21-04-2016 SPH21_RS22085 b9db103037872f7123a189dd7a8a1278 1088 PANTHER PTHR11532 498 581 5.6E-222 T 21-04-2016 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 Gene3D G3DSA:3.40.50.720 2 119 1.3E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 SUPERFAMILY SSF51735 1 122 7.17E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 SUPERFAMILY SSF52210 123 285 8.77E-51 T 21-04-2016 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 SMART SM00881 4 100 3.6E-37 T 21-04-2016 IPR003781 CoA-binding GO:0048037 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 TIGRFAM TIGR01019 sucCoAalpha: succinate-CoA ligase, alpha subunit 4 286 3.9E-127 T 21-04-2016 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 Gene3D G3DSA:3.40.50.261 120 286 2.0E-66 T 21-04-2016 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 Pfam PF02629 CoA binding domain 6 99 8.3E-31 T 21-04-2016 IPR003781 CoA-binding GO:0048037 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 PRINTS PR01798 Succinyl-CoA synthase signature 240 257 2.5E-29 T 21-04-2016 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 PRINTS PR01798 Succinyl-CoA synthase signature 177 195 2.5E-29 T 21-04-2016 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 PRINTS PR01798 Succinyl-CoA synthase signature 82 99 2.5E-29 T 21-04-2016 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 PRINTS PR01798 Succinyl-CoA synthase signature 208 221 2.5E-29 T 21-04-2016 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 ProSitePatterns PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 152 181 - T 21-04-2016 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 Pfam PF00549 CoA-ligase 151 265 4.8E-15 T 21-04-2016 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 ProSitePatterns PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 236 249 - T 21-04-2016 IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 PIRSF PIRSF001553 1 291 3.5E-125 T 21-04-2016 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SPH21_RS11965 e31fe47c9c165c06b81cae60af543ec9 293 PANTHER PTHR11117 1 291 1.2E-170 T 21-04-2016 SPH21_RS01020 3e3317c9b631026f75a614a28894f2b6 140 PIRSF PIRSF004681 1 140 3.9E-45 T 21-04-2016 IPR001602 Uncharacterised protein family UPF0047 SPH21_RS01020 3e3317c9b631026f75a614a28894f2b6 140 SUPERFAMILY SSF111038 1 140 4.97E-47 T 21-04-2016 IPR001602 Uncharacterised protein family UPF0047 SPH21_RS01020 3e3317c9b631026f75a614a28894f2b6 140 Pfam PF01894 Uncharacterised protein family UPF0047 20 136 6.9E-39 T 21-04-2016 IPR001602 Uncharacterised protein family UPF0047 SPH21_RS01020 3e3317c9b631026f75a614a28894f2b6 140 PANTHER PTHR30615 1 140 1.1E-73 T 21-04-2016 SPH21_RS01020 3e3317c9b631026f75a614a28894f2b6 140 TIGRFAM TIGR00149 TIGR00149_YjbQ: secondary thiamine-phosphate synthase enzyme 11 140 1.1E-41 T 21-04-2016 IPR001602 Uncharacterised protein family UPF0047 SPH21_RS01020 3e3317c9b631026f75a614a28894f2b6 140 Gene3D G3DSA:2.60.120.460 1 140 1.6E-54 T 21-04-2016 IPR001602 Uncharacterised protein family UPF0047 SPH21_RS01020 3e3317c9b631026f75a614a28894f2b6 140 ProSitePatterns PS01314 Uncharacterized protein family UPF0047 signature. 101 119 - T 21-04-2016 IPR001602 Uncharacterised protein family UPF0047 SPH21_RS16215 5638bb587e45ed01f2f631c0f40b2bf3 488 PANTHER PTHR11819:SF94 3 430 7.0E-71 T 21-04-2016 IPR031155 Urea active transporter GO:0015204|GO:0016021|GO:0071918 SPH21_RS16215 5638bb587e45ed01f2f631c0f40b2bf3 488 Pfam PF00474 Sodium:solute symporter family 34 431 9.8E-19 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS16215 5638bb587e45ed01f2f631c0f40b2bf3 488 PANTHER PTHR11819 3 430 7.0E-71 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 PIRSF PIRSF000477 1 270 9.1E-92 T 21-04-2016 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|UniPathway: UPA00606 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 Gene3D G3DSA:3.40.50.1580 2 269 1.1E-95 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 TIGRFAM TIGR01697 PNPH-PUNA-XAPA: inosine/guanosine/xanthosine phosphorylase family 22 268 2.3E-91 T 21-04-2016 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|UniPathway: UPA00606 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 ProSitePatterns PS01240 Purine and other phosphorylases family 2 signature. 75 116 - T 21-04-2016 IPR018099 Purine phosphorylase, family 2, conserved site GO:0016763 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 TIGRFAM TIGR01700 PNPH: purine nucleoside phosphorylase I, inosine and guanosine-specific 23 268 1.1E-94 T 21-04-2016 IPR011270 Purine nucleoside phosphorylase I, inosine/guanosine-specific GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|UniPathway: UPA00606 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 PANTHER PTHR11904:SF9 1 269 8.3E-111 T 21-04-2016 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|UniPathway: UPA00606 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 SUPERFAMILY SSF53167 2 268 4.84E-85 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 Pfam PF01048 Phosphorylase superfamily 23 269 8.3E-48 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS01700 4e13f204c90a2f4842ff23d038a93764 272 PANTHER PTHR11904 1 269 8.3E-111 T 21-04-2016 IPR001369 PNP/MTAP phosphorylase SPH21_RS13025 b67c0f198c553417842fb1d074867d18 409 PANTHER PTHR23501 12 407 2.3E-119 T 21-04-2016 SPH21_RS13025 b67c0f198c553417842fb1d074867d18 409 PANTHER PTHR23501:SF19 12 407 2.3E-119 T 21-04-2016 SPH21_RS13025 b67c0f198c553417842fb1d074867d18 409 Pfam PF07690 Major Facilitator Superfamily 20 327 2.1E-40 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS13025 b67c0f198c553417842fb1d074867d18 409 SUPERFAMILY SSF103473 13 406 1.24E-66 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13025 b67c0f198c553417842fb1d074867d18 409 Gene3D G3DSA:1.20.1250.20 220 402 1.2E-20 T 21-04-2016 SPH21_RS13025 b67c0f198c553417842fb1d074867d18 409 Gene3D G3DSA:1.20.1250.20 11 194 3.3E-29 T 21-04-2016 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 PRINTS PR00113 Alkaline phosphatase signature 371 391 2.5E-9 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 PRINTS PR00113 Alkaline phosphatase signature 287 307 2.5E-9 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 PRINTS PR00113 Alkaline phosphatase signature 474 503 2.5E-9 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 Gene3D G3DSA:3.20.20.190 105 261 1.2E-10 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 Gene3D G3DSA:3.40.720.10 262 607 3.9E-73 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 PANTHER PTHR11596 215 607 8.1E-52 T 21-04-2016 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 SUPERFAMILY SSF51695 31 256 1.41E-14 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 Pfam PF13653 Glycerophosphoryl diester phosphodiesterase family 221 250 1.5E-7 T 21-04-2016 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 SUPERFAMILY SSF53649 259 606 3.53E-78 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 PANTHER PTHR11596:SF5 215 607 8.1E-52 T 21-04-2016 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 SMART SM00098 288 609 8.9E-11 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 Pfam PF00245 Alkaline phosphatase 472 551 6.1E-19 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS04750 91a15002d7bbc1e3e2727f15788a7453 609 Pfam PF00245 Alkaline phosphatase 288 407 9.4E-17 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 SUPERFAMILY SSF102705 1 363 7.72E-123 T 21-04-2016 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 Gene3D G3DSA:3.40.1390.30 2 113 7.6E-45 T 21-04-2016 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 Pfam PF01784 NIF3 (NGG1p interacting factor 3) 6 348 4.8E-74 T 21-04-2016 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 TIGRFAM TIGR00486 YbgI_SA1388: dinuclear metal center protein, YbgI/SA1388 family 4 346 1.2E-53 T 21-04-2016 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 PANTHER PTHR13799 155 364 7.2E-106 T 21-04-2016 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 PANTHER PTHR13799 1 133 7.2E-106 T 21-04-2016 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 Gene3D G3DSA:3.40.1390.30 114 129 4.3E-33 T 21-04-2016 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 Gene3D G3DSA:3.40.1390.30 236 326 4.3E-33 T 21-04-2016 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 Gene3D G3DSA:3.30.70.830 130 235 1.7E-39 T 21-04-2016 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 PIRSF PIRSF037489 1 364 1.6E-134 T 21-04-2016 IPR017221 GTP cyclohydrolase 1 type 2//Nif3, bacteria SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 PANTHER PTHR13799:SF13 155 364 7.2E-106 T 21-04-2016 SPH21_RS06775 c94699bf24aaa9625b0169ee9cfa360c 365 PANTHER PTHR13799:SF13 1 133 7.2E-106 T 21-04-2016 SPH21_RS05740 e578ca006105d820012082820d97c372 359 SUPERFAMILY SSF101790 270 359 5.89E-28 T 21-04-2016 IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain SPH21_RS05740 e578ca006105d820012082820d97c372 359 Gene3D G3DSA:3.30.70.1400 52 139 3.4E-27 T 21-04-2016 SPH21_RS05740 e578ca006105d820012082820d97c372 359 PANTHER PTHR13847:SF5 2 357 2.3E-67 T 21-04-2016 IPR006223 Glycine cleavage system T protein GO:0004047|GO:0006546 KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SPH21_RS05740 e578ca006105d820012082820d97c372 359 Hamap MF_00259 Aminomethyltransferase [gcvT]. 1 359 43.899 T 21-04-2016 IPR022903 Glycine cleavage system T protein, bacteria GO:0004047|GO:0006546 KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SPH21_RS05740 e578ca006105d820012082820d97c372 359 PIRSF PIRSF006487 1 359 5.9E-103 T 21-04-2016 IPR028896 Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SPH21_RS05740 e578ca006105d820012082820d97c372 359 TIGRFAM TIGR00528 gcvT: glycine cleavage system T protein 2 359 4.7E-125 T 21-04-2016 IPR006223 Glycine cleavage system T protein GO:0004047|GO:0006546 KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SPH21_RS05740 e578ca006105d820012082820d97c372 359 PANTHER PTHR13847 2 357 2.3E-67 T 21-04-2016 SPH21_RS05740 e578ca006105d820012082820d97c372 359 Gene3D G3DSA:2.40.30.110 277 353 3.8E-29 T 21-04-2016 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SPH21_RS05740 e578ca006105d820012082820d97c372 359 SUPERFAMILY SSF103025 1 278 4.08E-99 T 21-04-2016 SPH21_RS05740 e578ca006105d820012082820d97c372 359 Gene3D G3DSA:3.30.1360.120 140 234 2.1E-54 T 21-04-2016 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SPH21_RS05740 e578ca006105d820012082820d97c372 359 Gene3D G3DSA:3.30.1360.120 2 51 2.1E-54 T 21-04-2016 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SPH21_RS05740 e578ca006105d820012082820d97c372 359 Pfam PF08669 Glycine cleavage T-protein C-terminal barrel domain 262 354 6.2E-28 T 21-04-2016 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SPH21_RS05740 e578ca006105d820012082820d97c372 359 Pfam PF01571 Aminomethyltransferase folate-binding domain 6 257 1.0E-96 T 21-04-2016 IPR006222 Glycine cleavage T-protein-like, N-terminal SPH21_RS03390 cf7c8c3eb35576f13e8ca6123371ee74 399 Pfam PF01609 Transposase DDE domain 130 339 1.6E-24 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS03390 cf7c8c3eb35576f13e8ca6123371ee74 399 SUPERFAMILY SSF53098 129 355 3.03E-29 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS03390 cf7c8c3eb35576f13e8ca6123371ee74 399 Gene3D G3DSA:3.90.350.10 290 315 3.8E-4 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS03390 cf7c8c3eb35576f13e8ca6123371ee74 399 PANTHER PTHR33258:SF1 7 398 8.4E-42 T 21-04-2016 SPH21_RS03390 cf7c8c3eb35576f13e8ca6123371ee74 399 PANTHER PTHR33258 7 398 8.4E-42 T 21-04-2016 SPH21_RS03390 cf7c8c3eb35576f13e8ca6123371ee74 399 Pfam PF14294 Domain of unknown function (DUF4372) 8 81 1.0E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS04705 3b1a218cdd49d6de32f968a40f30a2e2 158 SUPERFAMILY SSF55961 11 154 1.13E-29 T 21-04-2016 SPH21_RS04705 3b1a218cdd49d6de32f968a40f30a2e2 158 Gene3D G3DSA:3.30.530.20 4 155 5.7E-23 T 21-04-2016 IPR023393 START-like domain SPH21_RS04705 3b1a218cdd49d6de32f968a40f30a2e2 158 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 24 151 3.4E-11 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS09830 61e1cc439546c97f9c6d7bfd38df0f09 499 Gene3D G3DSA:1.25.40.10 215 321 7.3E-39 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09830 61e1cc439546c97f9c6d7bfd38df0f09 499 Gene3D G3DSA:1.25.40.10 354 440 7.3E-39 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09830 61e1cc439546c97f9c6d7bfd38df0f09 499 Pfam PF14322 Starch-binding associating with outer membrane 107 231 1.4E-25 T 21-04-2016 SPH21_RS09830 61e1cc439546c97f9c6d7bfd38df0f09 499 Pfam PF07980 SusD family 359 498 3.1E-35 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09830 61e1cc439546c97f9c6d7bfd38df0f09 499 SUPERFAMILY SSF48452 23 498 2.66E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26120 8be8d3e456d8b1e42df728ba4cc7faa7 134 SUPERFAMILY SSF54427 6 128 6.83E-20 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS26120 8be8d3e456d8b1e42df728ba4cc7faa7 134 Pfam PF07366 SnoaL-like polyketide cyclase 10 128 1.5E-19 T 21-04-2016 IPR009959 Polyketide cyclase SnoaL-like domain SPH21_RS26120 8be8d3e456d8b1e42df728ba4cc7faa7 134 Gene3D G3DSA:3.10.450.50 8 128 1.3E-18 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS08845 a3381c4fa69044f81f9ebaae2121b074 388 SUPERFAMILY SSF53756 59 383 5.71E-12 T 21-04-2016 SPH21_RS10905 864b5580698d86ab6dc43f2d450fbfed 149 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 6 120 7.4E-25 T 21-04-2016 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 SPH21_RS10905 864b5580698d86ab6dc43f2d450fbfed 149 PIRSF PIRSF006019 1 144 1.5E-41 T 21-04-2016 IPR016473 Deoxycytidylate deaminase GO:0004132|GO:0006220|GO:0008270 KEGG: 00240+3.5.4.12|MetaCyc: PWY-7210 SPH21_RS10905 864b5580698d86ab6dc43f2d450fbfed 149 PANTHER PTHR11086:SF4 1 124 4.8E-36 T 21-04-2016 SPH21_RS10905 864b5580698d86ab6dc43f2d450fbfed 149 SUPERFAMILY SSF53927 7 146 4.3E-37 T 21-04-2016 IPR016193 Cytidine deaminase-like GO:0003824 SPH21_RS10905 864b5580698d86ab6dc43f2d450fbfed 149 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 75 110 - T 21-04-2016 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 SPH21_RS10905 864b5580698d86ab6dc43f2d450fbfed 149 Gene3D G3DSA:3.40.140.10 6 143 4.9E-37 T 21-04-2016 SPH21_RS10905 864b5580698d86ab6dc43f2d450fbfed 149 PANTHER PTHR11086 1 124 4.8E-36 T 21-04-2016 IPR015517 Deoxycytidylate deaminase-related SPH21_RS22585 7296defeb1a6d3332c2ed1418eb0957a 124 SMART SM00883 11 116 3.8E-5 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS22585 7296defeb1a6d3332c2ed1418eb0957a 124 Gene3D G3DSA:2.30.33.40 10 116 7.6E-19 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS22585 7296defeb1a6d3332c2ed1418eb0957a 124 Pfam PF00166 Chaperonin 10 Kd subunit 12 116 2.6E-11 T 21-04-2016 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SPH21_RS22585 7296defeb1a6d3332c2ed1418eb0957a 124 SUPERFAMILY SSF50129 10 117 1.53E-15 T 21-04-2016 IPR011032 GroES-like SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 PANTHER PTHR32108 3 330 6.6E-109 T 21-04-2016 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 Pfam PF01000 RNA polymerase Rpb3/RpoA insert domain 62 156 3.4E-19 T 21-04-2016 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 Hamap MF_00059 DNA-directed RNA polymerase subunit alpha [rpoA]. 3 321 33.788 T 21-04-2016 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 Pfam PF03118 Bacterial RNA polymerase, alpha chain C terminal domain 251 312 5.9E-22 T 21-04-2016 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 Pfam PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain 27 225 4.6E-24 T 21-04-2016 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 Gene3D G3DSA:1.10.150.20 251 328 3.3E-27 T 21-04-2016 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 ProDom PD001179 RNA POLYMERASE ALPHA DNA-DIRECTED SUBUNIT CHAIN NUCLEOTIDYLTRANSFERASE TRANSFERASE TRANSCRIPTION TRANSCRIPTASE 263 322 1.0E-15 T 21-04-2016 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 Gene3D G3DSA:2.170.120.12 65 174 1.0E-38 T 21-04-2016 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 SUPERFAMILY SSF55257 7 51 5.18E-29 T 21-04-2016 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 SUPERFAMILY SSF55257 176 230 5.18E-29 T 21-04-2016 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 SMART SM00662 21 231 1.3E-69 T 21-04-2016 IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 SUPERFAMILY SSF56553 51 175 1.7E-36 T 21-04-2016 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: REACT_1788 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 SUPERFAMILY SSF47789 255 327 3.79E-21 T 21-04-2016 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 TIGRFAM TIGR02027 rpoA: DNA-directed RNA polymerase, alpha subunit 22 321 8.7E-112 T 21-04-2016 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 Gene3D G3DSA:3.30.1360.10 8 64 2.4E-10 T 21-04-2016 SPH21_RS08625 ceb642af7748c7cdb9572f323d0a7dfc 330 PANTHER PTHR32108:SF0 3 330 6.6E-109 T 21-04-2016 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 SMART SM00347 28 129 1.1E-10 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 ProSitePatterns PS01117 MarR-type HTH domain signature. 68 102 - T 21-04-2016 IPR023187 Transcriptional regulator MarR-type, conserved site SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 Pfam PF12802 MarR family 40 92 4.4E-8 T 21-04-2016 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 PRINTS PR00598 Bacterial regulatory protein MarR family signature 70 85 4.3E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 PRINTS PR00598 Bacterial regulatory protein MarR family signature 53 69 4.3E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 PRINTS PR00598 Bacterial regulatory protein MarR family signature 119 139 4.3E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 PRINTS PR00598 Bacterial regulatory protein MarR family signature 89 105 4.3E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 PANTHER PTHR33164 15 146 4.9E-14 T 21-04-2016 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 PANTHER PTHR33164:SF16 15 146 4.9E-14 T 21-04-2016 SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 Gene3D G3DSA:1.10.10.10 6 145 9.3E-26 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS26315 df86d79c4144c48f3bc39541f306430b 149 SUPERFAMILY SSF46785 9 146 2.56E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 Pfam PF01029 NusB family 193 296 1.3E-22 T 21-04-2016 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 PANTHER PTHR11078 46 314 1.4E-24 T 21-04-2016 IPR011605 NusB antitermination factor GO:0006353 SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 Gene3D G3DSA:1.10.940.10 177 296 1.2E-34 T 21-04-2016 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 Gene3D G3DSA:1.10.940.10 131 174 1.1E-5 T 21-04-2016 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 Gene3D G3DSA:1.10.940.10 1 33 1.1E-5 T 21-04-2016 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 TIGRFAM TIGR01951 nusB: transcription antitermination factor NusB 184 297 5.3E-27 T 21-04-2016 IPR011605 NusB antitermination factor GO:0006353 SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 SUPERFAMILY SSF48013 177 304 1.31E-24 T 21-04-2016 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SPH21_RS19885 98d728a2c2eec7d6219b6e1f2cd7e9df 315 Hamap MF_00073 N utilization substance protein B homolog [nusB]. 2 301 16.912 T 21-04-2016 IPR011605 NusB antitermination factor GO:0006353 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Gene3D G3DSA:3.40.190.10 3 103 2.8E-39 T 21-04-2016 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Gene3D G3DSA:3.40.190.10 104 202 5.2E-31 T 21-04-2016 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Pfam PF01379 Porphobilinogen deaminase, dipyromethane cofactor binding domain 5 215 1.9E-72 T 21-04-2016 IPR022417 Porphobilinogen deaminase, N-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Gene3D G3DSA:3.40.50.10090 445 523 2.1E-6 T 21-04-2016 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 SUPERFAMILY SSF69618 304 524 2.22E-23 T 21-04-2016 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Pfam PF02602 Uroporphyrinogen-III synthase HemD 328 508 4.4E-21 T 21-04-2016 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Hamap MF_00260 Porphobilinogen deaminase [hemC]. 4 294 31.716 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 PRINTS PR00151 Porphobilinogen deaminase signature 125 142 4.7E-36 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 PRINTS PR00151 Porphobilinogen deaminase signature 42 62 4.7E-36 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 PRINTS PR00151 Porphobilinogen deaminase signature 73 92 4.7E-36 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 PRINTS PR00151 Porphobilinogen deaminase signature 144 161 4.7E-36 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 PRINTS PR00151 Porphobilinogen deaminase signature 233 250 4.7E-36 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 SUPERFAMILY SSF53850 3 221 6.4E-68 T 21-04-2016 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 SUPERFAMILY SSF54782 228 294 7.06E-7 T 21-04-2016 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Gene3D G3DSA:3.40.50.10090 349 444 3.7E-10 T 21-04-2016 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 PANTHER PTHR11557:SF0 3 252 3.1E-93 T 21-04-2016 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 PANTHER PTHR11557 3 252 3.1E-93 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 Gene3D G3DSA:3.30.160.40 229 257 5.4E-4 T 21-04-2016 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25585 9352eb835c0472fa4225f59d7e664442 546 TIGRFAM TIGR00212 hemC: hydroxymethylbilane synthase 5 258 6.2E-90 T 21-04-2016 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS16150 5431f65c9a8c4ee75bec1832ffabd960 500 Gene3D G3DSA:1.10.150.20 189 224 9.2E-4 T 21-04-2016 SPH21_RS16150 5431f65c9a8c4ee75bec1832ffabd960 500 PANTHER PTHR35369 39 500 4.6E-87 T 21-04-2016 SPH21_RS16150 5431f65c9a8c4ee75bec1832ffabd960 500 Pfam PF00817 impB/mucB/samB family 20 150 6.5E-14 T 21-04-2016 IPR001126 UmuC domain GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS16150 5431f65c9a8c4ee75bec1832ffabd960 500 SUPERFAMILY SSF56672 4 231 6.94E-43 T 21-04-2016 SPH21_RS16150 5431f65c9a8c4ee75bec1832ffabd960 500 PANTHER PTHR35369:SF2 39 500 4.6E-87 T 21-04-2016 SPH21_RS25090 9ae0e330bc14ed4ae4dbbebc1f84a84c 142 Gene3D G3DSA:3.90.1170.40 16 140 4.3E-37 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS25090 9ae0e330bc14ed4ae4dbbebc1f84a84c 142 SUPERFAMILY SSF54690 17 139 1.11E-32 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS25090 9ae0e330bc14ed4ae4dbbebc1f84a84c 142 PANTHER PTHR23404 27 142 1.3E-26 T 21-04-2016 SPH21_RS25090 9ae0e330bc14ed4ae4dbbebc1f84a84c 142 Pfam PF02391 MoaE protein 17 120 1.4E-27 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS25090 9ae0e330bc14ed4ae4dbbebc1f84a84c 142 PANTHER PTHR23404:SF2 27 142 1.3E-26 T 21-04-2016 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 SUPERFAMILY SSF56935 443 784 5.49E-88 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 SUPERFAMILY SSF56935 862 906 5.49E-88 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 SUPERFAMILY SSF56935 112 258 5.49E-88 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 SUPERFAMILY SSF56935 947 1025 5.49E-88 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 SUPERFAMILY SSF56935 328 416 5.49E-88 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Pfam PF07715 TonB-dependent Receptor Plug Domain 125 232 2.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 PANTHER PTHR11532 574 1023 6.9E-234 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 PANTHER PTHR11532 19 382 6.9E-234 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 PANTHER PTHR11532 476 542 6.9E-234 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 208 238 6.4E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 PANTHER PTHR11532:SF57 574 1023 6.9E-234 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 PANTHER PTHR11532:SF57 19 382 6.9E-234 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 PANTHER PTHR11532:SF57 476 542 6.9E-234 T 21-04-2016 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Gene3D G3DSA:2.60.40.1120 39 118 4.6E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Gene3D G3DSA:2.170.130.10 119 232 1.7E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 SUPERFAMILY SSF49464 36 116 1.18E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Gene3D G3DSA:2.40.170.20 337 803 1.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Gene3D G3DSA:2.40.170.20 942 1025 1.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Gene3D G3DSA:2.40.170.20 233 252 1.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Gene3D G3DSA:2.40.170.20 871 896 1.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 37 1025 1.2E-247 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS21100 6e26340e9a2a2befc4711ecb1a76c96f 1025 Pfam PF13715 CarboxypepD_reg-like domain 39 118 5.8E-15 T 21-04-2016 SPH21_RS00660 5b6132a7a9ebbefa09f01a31491da095 150 SUPERFAMILY SSF54427 25 140 6.36E-24 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS00660 5b6132a7a9ebbefa09f01a31491da095 150 Gene3D G3DSA:3.10.450.50 24 141 9.2E-33 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS00660 5b6132a7a9ebbefa09f01a31491da095 150 Pfam PF14534 Domain of unknown function (DUF4440) 29 134 1.3E-12 T 21-04-2016 IPR027843 Domain of unknown function DUF4440 SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 SUPERFAMILY SSF51126 29 455 2.29E-96 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 SMART SM00710 274 295 910.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 SMART SM00710 335 356 140.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 SMART SM00710 224 244 9400.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 SMART SM00710 308 329 7.3 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 SMART SM00710 247 273 16.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 Pfam PF12708 Pectate lyase superfamily protein 37 159 4.2E-7 T 21-04-2016 IPR024535 Pectate lyase superfamily protein SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 PANTHER PTHR31339 203 450 1.3E-121 T 21-04-2016 SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 PANTHER PTHR31339 24 150 1.3E-121 T 21-04-2016 SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 Gene3D G3DSA:2.160.20.10 202 466 1.3E-114 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 Gene3D G3DSA:2.160.20.10 30 160 1.3E-114 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 Pfam PF00295 Glycosyl hydrolases family 28 215 393 3.1E-29 T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 PANTHER PTHR31339:SF0 203 450 1.3E-121 T 21-04-2016 SPH21_RS14370 7f6418a571641412e31eae26c9ac21d7 543 PANTHER PTHR31339:SF0 24 150 1.3E-121 T 21-04-2016 SPH21_RS02960 edbc403853ebdea7f135b1d8da2b3604 380 Gene3D G3DSA:2.70.98.10 38 379 2.7E-131 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS02960 edbc403853ebdea7f135b1d8da2b3604 380 PANTHER PTHR10091 22 379 1.3E-153 T 21-04-2016 SPH21_RS02960 edbc403853ebdea7f135b1d8da2b3604 380 SUPERFAMILY SSF74650 38 377 2.7E-115 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS02960 edbc403853ebdea7f135b1d8da2b3604 380 Pfam PF01263 Aldose 1-epimerase 48 374 4.3E-91 T 21-04-2016 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 SPH21_RS02960 edbc403853ebdea7f135b1d8da2b3604 380 PIRSF PIRSF005096 29 379 3.4E-131 T 21-04-2016 IPR015443 Aldose 1-epimerase GO:0016853|GO:0019318 KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317|UniPathway: UPA00242 SPH21_RS02960 edbc403853ebdea7f135b1d8da2b3604 380 PANTHER PTHR10091:SF0 22 379 1.3E-153 T 21-04-2016 SPH21_RS07095 e00cba8a49bd5b0e09cc0f9d2b88aa25 310 SUPERFAMILY SSF48452 226 285 4.07E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07095 e00cba8a49bd5b0e09cc0f9d2b88aa25 310 Gene3D G3DSA:1.25.40.10 224 284 3.5E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07095 e00cba8a49bd5b0e09cc0f9d2b88aa25 310 Pfam PF11138 Protein of unknown function (DUF2911) 61 205 3.4E-59 T 21-04-2016 IPR021314 Protein of unknown function DUF2911 SPH21_RS13915 6ee1898228e5af82d190c1f000537dcf 379 PANTHER PTHR22953:SF0 200 273 3.1E-12 T 21-04-2016 SPH21_RS13915 6ee1898228e5af82d190c1f000537dcf 379 PANTHER PTHR22953:SF0 43 179 3.1E-12 T 21-04-2016 SPH21_RS13915 6ee1898228e5af82d190c1f000537dcf 379 PANTHER PTHR22953 200 273 3.1E-12 T 21-04-2016 SPH21_RS13915 6ee1898228e5af82d190c1f000537dcf 379 PANTHER PTHR22953 43 179 3.1E-12 T 21-04-2016 SPH21_RS13915 6ee1898228e5af82d190c1f000537dcf 379 Pfam PF00149 Calcineurin-like phosphoesterase 51 270 1.7E-13 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS13915 6ee1898228e5af82d190c1f000537dcf 379 SUPERFAMILY SSF56300 51 338 4.21E-37 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS13915 6ee1898228e5af82d190c1f000537dcf 379 Gene3D G3DSA:3.60.21.10 48 362 1.1E-45 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS20050 52f4fb16e1a3c4d894bbe65d713f43d7 161 Pfam PF08592 Domain of unknown function (DUF1772) 18 155 1.8E-16 T 21-04-2016 IPR013901 Protein of unknown function DUF1772 SPH21_RS22000 c811c91fd01b4d9d05c49afbffe8689b 304 SUPERFAMILY SSF46689 256 302 8.51E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22000 c811c91fd01b4d9d05c49afbffe8689b 304 PANTHER PTHR11019:SF50 67 304 9.7E-32 T 21-04-2016 SPH21_RS22000 c811c91fd01b4d9d05c49afbffe8689b 304 PANTHER PTHR11019 67 304 9.7E-32 T 21-04-2016 SPH21_RS22000 c811c91fd01b4d9d05c49afbffe8689b 304 SMART SM00342 218 301 1.3E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22000 c811c91fd01b4d9d05c49afbffe8689b 304 Gene3D G3DSA:1.10.10.60 256 302 3.2E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22000 c811c91fd01b4d9d05c49afbffe8689b 304 Pfam PF12833 Helix-turn-helix domain 224 302 1.6E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 79 188 8.8E-10 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 SUPERFAMILY SSF56784 9 193 2.15E-29 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 PANTHER PTHR12725 1 188 9.8E-18 T 21-04-2016 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 Gene3D G3DSA:1.10.150.240 23 83 2.0E-30 T 21-04-2016 IPR023198 Phosphoglycolate phosphatase, domain 2 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 Pfam PF13419 Haloacid dehalogenase-like hydrolase 77 186 1.3E-14 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 PANTHER PTHR12725:SF63 1 188 9.8E-18 T 21-04-2016 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 8 19 2.0E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 102 115 2.0E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 134 150 2.0E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 152 172 2.0E-7 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS10790 2a9e75e5d5c9d23e40656b3c5a9577f5 206 Gene3D G3DSA:3.40.50.1000 84 203 4.1E-26 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 SUPERFAMILY SSF47413 3 61 2.09E-14 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 Pfam PF13377 Periplasmic binding protein-like domain 174 334 4.4E-29 T 21-04-2016 SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 Gene3D G3DSA:1.10.260.40 5 55 1.1E-18 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 50 6.3E-10 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 SUPERFAMILY SSF53822 62 335 1.97E-58 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 SMART SM00354 3 73 4.2E-18 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 PANTHER PTHR30146 3 335 6.7E-93 T 21-04-2016 SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 Gene3D G3DSA:3.40.50.2300 177 311 9.7E-36 T 21-04-2016 SPH21_RS19360 3119a1fd372a1f43a303358d6790a373 345 Gene3D G3DSA:3.40.50.2300 56 176 4.5E-41 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 Gene3D G3DSA:1.25.40.10 855 1001 1.1E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214 549 675 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214 297 343 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214 754 1009 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214 2 228 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214 411 533 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214:SF2 549 675 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214:SF2 297 343 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214:SF2 754 1009 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214:SF2 2 228 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 PANTHER PTHR16214:SF2 411 533 1.1E-193 T 21-04-2016 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 Pfam PF11028 Protein of unknown function (DUF2723) 34 212 6.9E-70 T 21-04-2016 IPR021280 Protein of unknown function DUF2723 SPH21_RS25385 b890c8cb0ea1ae39ca21b363ccac3929 1011 SUPERFAMILY SSF48452 874 958 5.46E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 Gene3D G3DSA:1.10.1740.10 5 98 2.3E-17 T 21-04-2016 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 164 176 2.7E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 148 164 2.7E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 Pfam PF08281 Sigma-70, region 4 131 174 1.5E-11 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 23 180 3.7E-42 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 Gene3D G3DSA:1.10.10.10 121 182 2.4E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 Pfam PF04542 Sigma-70 region 2 29 90 1.4E-6 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 180 1.7E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 PANTHER PTHR30173 1 188 3.3E-45 T 21-04-2016 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 SUPERFAMILY SSF88659 111 182 2.18E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 PANTHER PTHR30173:SF20 1 188 3.3E-45 T 21-04-2016 SPH21_RS02275 6e4050815e873f9346915f48aac9429c 188 SUPERFAMILY SSF88946 3 104 3.4E-18 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02990 e9127a9940ac51971f9c1d712cf3ce3d 614 Gene3D G3DSA:1.25.40.10 436 523 6.2E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02990 e9127a9940ac51971f9c1d712cf3ce3d 614 Gene3D G3DSA:1.25.40.10 192 331 6.2E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02990 e9127a9940ac51971f9c1d712cf3ce3d 614 SUPERFAMILY SSF48452 582 612 2.15E-93 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02990 e9127a9940ac51971f9c1d712cf3ce3d 614 SUPERFAMILY SSF48452 18 546 2.15E-93 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02990 e9127a9940ac51971f9c1d712cf3ce3d 614 Pfam PF14322 Starch-binding associating with outer membrane 77 213 1.6E-13 T 21-04-2016 SPH21_RS02990 e9127a9940ac51971f9c1d712cf3ce3d 614 Pfam PF07980 SusD family 289 612 1.5E-35 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 Pfam PF12704 MacB-like periplasmic core domain 20 239 4.3E-16 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 Pfam PF12704 MacB-like periplasmic core domain 425 638 1.3E-8 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 PANTHER PTHR30572:SF4 408 793 2.3E-52 T 21-04-2016 SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 PANTHER PTHR30572:SF4 280 347 2.3E-52 T 21-04-2016 SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 PANTHER PTHR30572 408 793 2.3E-52 T 21-04-2016 SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 PANTHER PTHR30572 280 347 2.3E-52 T 21-04-2016 SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 Pfam PF02687 FtsX-like permease family 674 780 1.5E-9 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05945 6b00abe7120b872f2ea31a9cb3c0d323 793 Pfam PF02687 FtsX-like permease family 281 396 6.3E-14 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 ProSitePatterns PS01305 moaA / nifB / pqqE family signature. 17 28 - T 21-04-2016 IPR000385 MoaA/nifB/pqqE, iron-sulphur binding, conserved site GO:0003824|GO:0046872|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 TIGRFAM TIGR02666 moaA: molybdenum cofactor biosynthesis protein A 2 326 5.7E-101 T 21-04-2016 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 Pfam PF06463 Molybdenum Cofactor Synthesis C 180 298 3.3E-32 T 21-04-2016 IPR010505 Molybdenum cofactor synthesis C-terminal GO:0006777|GO:0019008|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|UniPathway: UPA00344 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 Gene3D G3DSA:3.20.20.70 3 276 1.8E-70 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 PANTHER PTHR22960 1 276 5.6E-115 T 21-04-2016 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 SMART SM00729 11 211 1.4E-8 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 Pfam PF13394 4Fe-4S single cluster domain 18 98 1.1E-5 T 21-04-2016 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 Pfam PF04055 Radical SAM superfamily 16 173 1.5E-29 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS18615 e3727921801a4665ed7246ca4e63637d 326 SUPERFAMILY SSF102114 3 270 1.7E-67 T 21-04-2016 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 183 195 8.2E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 153 167 8.2E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 167 183 8.2E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 PANTHER PTHR26402:SF151 8 211 1.1E-56 T 21-04-2016 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 Gene3D G3DSA:1.10.10.10 158 212 2.6E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 Gene3D G3DSA:3.40.50.2300 6 157 3.9E-35 T 21-04-2016 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 SUPERFAMILY SSF52172 7 137 6.12E-31 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 PANTHER PTHR26402 8 211 1.1E-56 T 21-04-2016 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 SMART SM00421 150 207 1.2E-19 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 SUPERFAMILY SSF46894 147 212 4.08E-17 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 SMART SM00448 8 121 2.4E-26 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 Pfam PF00072 Response regulator receiver domain 11 122 6.1E-25 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17670 c5838c1477b679ae36c4dd59bc02df1c 213 Pfam PF00196 Bacterial regulatory proteins, luxR family 152 205 9.4E-19 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS02210 d8efefa1e5aaff4caa8cef56dd8a7547 294 PANTHER PTHR11048:SF27 1 179 1.0E-21 T 21-04-2016 SPH21_RS02210 d8efefa1e5aaff4caa8cef56dd8a7547 294 Pfam PF01040 UbiA prenyltransferase family 23 231 1.1E-22 T 21-04-2016 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SPH21_RS02210 d8efefa1e5aaff4caa8cef56dd8a7547 294 PANTHER PTHR11048 1 179 1.0E-21 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PRINTS PR00344 Bacterial sensor protein C-terminal signature 416 434 1.0E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PRINTS PR00344 Bacterial sensor protein C-terminal signature 441 454 1.0E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PRINTS PR00344 Bacterial sensor protein C-terminal signature 403 413 1.0E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PRINTS PR00344 Bacterial sensor protein C-terminal signature 385 399 1.0E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 SUPERFAMILY SSF55874 289 454 2.23E-30 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 SUPERFAMILY SSF47384 197 289 1.14E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 SMART SM00387 334 457 2.2E-17 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 Gene3D G3DSA:3.30.565.10 290 454 6.0E-33 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 Pfam PF00512 His Kinase A (phospho-acceptor) domain 202 288 5.6E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 SMART SM00388 202 288 1.8E-4 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 337 456 1.3E-15 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423:SF360 40 48 5.5E-51 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423:SF360 186 230 5.5E-51 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423:SF360 385 457 5.5E-51 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423:SF360 252 364 5.5E-51 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 Gene3D G3DSA:1.10.287.130 197 284 1.5E-6 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423 40 48 5.5E-51 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423 186 230 5.5E-51 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423 385 457 5.5E-51 T 21-04-2016 SPH21_RS11115 a2c9b2ad7a7373691a704b198ab13c91 457 PANTHER PTHR24423 252 364 5.5E-51 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PANTHER PTHR32063:SF24 2 1085 0.0 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF56954 1039 1451 7.98E-45 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 TIGRFAM TIGR00914 2A0601: heavy metal efflux pump, CzcA family 1 1038 0.0 T 21-04-2016 IPR004763 Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA GO:0006812|GO:0008324|GO:0016021 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Gene3D G3DSA:1.20.1600.10 1060 1451 1.5E-66 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Gene3D G3DSA:3.30.2090.10 187 270 1.6E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Gene3D G3DSA:3.30.2090.10 726 810 6.3E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Pfam PF02321 Outer membrane efflux protein 1277 1451 5.6E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Pfam PF02321 Outer membrane efflux protein 1069 1242 2.7E-9 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Gene3D G3DSA:1.10.3850.10 284 506 9.9E-49 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Gene3D G3DSA:1.10.3850.10 817 1035 2.4E-55 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF82866 810 1035 2.62E-52 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Gene3D G3DSA:3.30.70.1430 42 140 8.2E-22 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF82693 150 186 3.14E-16 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF82693 272 329 3.14E-16 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PANTHER PTHR32063 2 1085 0.0 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF82693 42 117 2.88E-19 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF82866 295 503 2.09E-33 T 21-04-2016 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PRINTS PR00702 Acriflavin resistance protein family signature 12 36 6.0E-21 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PRINTS PR00702 Acriflavin resistance protein family signature 477 500 6.0E-21 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PRINTS PR00702 Acriflavin resistance protein family signature 452 475 6.0E-21 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PRINTS PR00702 Acriflavin resistance protein family signature 553 570 6.0E-21 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PRINTS PR00702 Acriflavin resistance protein family signature 40 58 6.0E-21 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 PRINTS PR00702 Acriflavin resistance protein family signature 335 358 6.0E-21 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 Pfam PF00873 AcrB/AcrD/AcrF family 5 1033 8.5E-274 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF82714 726 809 3.4E-15 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS04395 ecb251ed2bfe42dfa9a6f46090ded4b1 1454 SUPERFAMILY SSF82714 187 269 2.35E-15 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS04890 ec21d3d136459e4224e6352cdf99af5c 464 Pfam PF12771 Starch-binding associating with outer membrane 1 446 9.0E-38 T 21-04-2016 SPH21_RS04890 ec21d3d136459e4224e6352cdf99af5c 464 SUPERFAMILY SSF48452 19 462 1.26E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04890 ec21d3d136459e4224e6352cdf99af5c 464 PANTHER PTHR35148 1 464 1.8E-40 T 21-04-2016 SPH21_RS00975 6559351cc4a5d46582521068d21c15b6 294 Pfam PF05153 Myo-inositol oxygenase 52 293 1.7E-113 T 21-04-2016 IPR007828 Inositol oxygenase GO:0005506|GO:0005737|GO:0019310|GO:0050113|GO:0055114 KEGG: 00053+1.13.99.1|KEGG: 00562+1.13.99.1|MetaCyc: PWY-4841|UniPathway: UPA00111 SPH21_RS00975 6559351cc4a5d46582521068d21c15b6 294 SUPERFAMILY SSF109604 45 292 9.42E-108 T 21-04-2016 SPH21_RS00975 6559351cc4a5d46582521068d21c15b6 294 PANTHER PTHR12588 21 294 7.0E-153 T 21-04-2016 IPR007828 Inositol oxygenase GO:0005506|GO:0005737|GO:0019310|GO:0050113|GO:0055114 KEGG: 00053+1.13.99.1|KEGG: 00562+1.13.99.1|MetaCyc: PWY-4841|UniPathway: UPA00111 SPH21_RS00975 6559351cc4a5d46582521068d21c15b6 294 PANTHER PTHR12588:SF0 21 294 7.0E-153 T 21-04-2016 SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 Gene3D G3DSA:1.10.10.10 17 146 2.3E-31 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 Pfam PF01047 MarR family 38 95 1.4E-14 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 SMART SM00347 31 131 2.5E-21 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 PANTHER PTHR33164 20 147 4.0E-21 T 21-04-2016 SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 SUPERFAMILY SSF46785 17 146 1.64E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 PRINTS PR00598 Bacterial regulatory protein MarR family signature 72 87 6.8E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 PRINTS PR00598 Bacterial regulatory protein MarR family signature 55 71 6.8E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 PRINTS PR00598 Bacterial regulatory protein MarR family signature 91 107 6.8E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS16410 f472a05be84efa569fbd30f08a30ce4a 147 PRINTS PR00598 Bacterial regulatory protein MarR family signature 121 141 6.8E-9 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 Gene3D G3DSA:3.40.50.720 2 139 2.2E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 PANTHER PTHR21499:SF2 7 309 2.3E-87 T 21-04-2016 SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 Pfam PF00742 Homoserine dehydrogenase 128 306 1.5E-50 T 21-04-2016 IPR001342 Homoserine dehydrogenase, catalytic GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 Gene3D G3DSA:3.30.360.10 140 291 1.5E-38 T 21-04-2016 SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 Pfam PF03447 Homoserine dehydrogenase, NAD binding domain 11 120 3.8E-13 T 21-04-2016 IPR005106 Aspartate/homoserine dehydrogenase, NAD-binding GO:0016491|GO:0050661|GO:0055114 SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 PANTHER PTHR21499 7 309 2.3E-87 T 21-04-2016 SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 SUPERFAMILY SSF51735 1 149 5.48E-26 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 SUPERFAMILY SSF55347 128 294 1.83E-38 T 21-04-2016 SPH21_RS16850 bfdb5e0125f5d7eb89c98f8be68f9eff 393 ProSitePatterns PS01042 Homoserine dehydrogenase signature. 174 196 - T 21-04-2016 IPR019811 Homoserine dehydrogenase, conserved site GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 Gene3D G3DSA:3.40.50.720 191 476 2.5E-90 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 SMART SM00839 192 474 8.4E-76 T 21-04-2016 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 SUPERFAMILY SSF53223 11 192 4.8E-58 T 21-04-2016 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 Gene3D G3DSA:3.40.192.10 43 188 2.6E-54 T 21-04-2016 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 181 203 9.7E-31 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 97 111 9.7E-31 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 360 371 9.7E-31 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 231 251 9.7E-31 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 PIRSF PIRSF000185 8 477 7.5E-140 T 21-04-2016 IPR014362 Glutamate dehydrogenase GO:0016639|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 PANTHER PTHR11606:SF13 1 475 6.4E-218 T 21-04-2016 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 ProSitePatterns PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 105 118 - T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 PANTHER PTHR11606 1 475 6.4E-218 T 21-04-2016 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 41 168 4.1E-56 T 21-04-2016 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 SUPERFAMILY SSF51735 195 476 4.37E-68 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14850 dfaadc122772828052589f8f6125aa34 477 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 191 424 1.5E-53 T 21-04-2016 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 SPH21_RS24715 80a1faa0fac0d04e979c93bbf7f7510c 482 SUPERFAMILY SSF48452 25 482 1.14E-79 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24715 80a1faa0fac0d04e979c93bbf7f7510c 482 Gene3D G3DSA:1.25.40.10 227 434 7.8E-24 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24715 80a1faa0fac0d04e979c93bbf7f7510c 482 Pfam PF07980 SusD family 362 482 1.1E-23 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS24715 80a1faa0fac0d04e979c93bbf7f7510c 482 Pfam PF14322 Starch-binding associating with outer membrane 32 244 3.8E-26 T 21-04-2016 SPH21_RS21290 b6450ed528d13f8e65d69a1213137ddd 272 Pfam PF13115 YtkA-like 177 250 1.1E-8 T 21-04-2016 IPR032693 YtkA-like domain SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 Gene3D G3DSA:2.102.10.10 416 500 6.4E-31 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 SUPERFAMILY SSF50022 380 500 4.58E-26 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 SUPERFAMILY SSF51905 330 386 1.94E-27 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 SUPERFAMILY SSF51905 26 228 1.94E-27 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 PRINTS PR00162 Rieske 2Fe-2S subunit signature 449 460 6.2E-8 T 21-04-2016 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 PRINTS PR00162 Rieske 2Fe-2S subunit signature 470 482 6.2E-8 T 21-04-2016 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 PRINTS PR00162 Rieske 2Fe-2S subunit signature 482 494 6.2E-8 T 21-04-2016 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 PANTHER PTHR13847 17 449 7.0E-40 T 21-04-2016 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 PANTHER PTHR13847:SF196 17 449 7.0E-40 T 21-04-2016 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 Pfam PF00355 Rieske [2Fe-2S] domain 416 495 4.0E-15 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 Pfam PF01266 FAD dependent oxidoreductase 27 366 2.6E-34 T 21-04-2016 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 Gene3D G3DSA:3.50.50.60 20 117 6.5E-37 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 Gene3D G3DSA:3.50.50.60 330 385 6.5E-37 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12810 c9217c6ce2c46b6649e2325f01e46ba3 504 Gene3D G3DSA:3.50.50.60 163 240 6.5E-37 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 Gene3D G3DSA:3.40.50.1100 106 198 2.3E-12 T 21-04-2016 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 Gene3D G3DSA:3.40.50.1100 199 410 2.5E-69 T 21-04-2016 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 Gene3D G3DSA:3.90.1380.10 1 85 1.3E-20 T 21-04-2016 IPR029144 Threonine synthase, N-terminal SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 97 111 - T 21-04-2016 IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site GO:0006520|GO:0030170 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 PANTHER PTHR10314 53 435 2.2E-121 T 21-04-2016 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 PANTHER PTHR10314 25 36 2.2E-121 T 21-04-2016 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 Pfam PF14821 Threonine synthase N terminus 4 79 7.7E-17 T 21-04-2016 IPR029144 Threonine synthase, N-terminal SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 TIGRFAM TIGR00260 thrC: threonine synthase 69 394 2.3E-85 T 21-04-2016 IPR004450 Threonine synthase-like SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 SUPERFAMILY SSF53686 1 435 2.45E-130 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 PANTHER PTHR10314:SF1 53 435 2.2E-121 T 21-04-2016 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 PANTHER PTHR10314:SF1 25 36 2.2E-121 T 21-04-2016 SPH21_RS07030 8331a7dd0b4614b036f8f9aa22028168 437 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 97 384 3.7E-23 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 64 2.9E-11 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 5.0E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 5.0E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 Gene3D G3DSA:1.10.357.10 1 176 2.3E-31 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 SUPERFAMILY SSF48498 88 177 1.31E-11 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 PANTHER PTHR30055:SF23 1 174 3.8E-23 T 21-04-2016 SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 SUPERFAMILY SSF46689 6 88 1.13E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 PANTHER PTHR30055 1 174 3.8E-23 T 21-04-2016 SPH21_RS24165 fd39384af960f8e5155e3722482fb441 199 Pfam PF13305 WHG domain 92 173 9.8E-14 T 21-04-2016 IPR025996 WHG domain SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 Gene3D G3DSA:3.40.50.970 17 189 2.9E-45 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 Gene3D G3DSA:3.40.50.920 190 320 4.4E-33 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 PANTHER PTHR11624 17 323 7.1E-83 T 21-04-2016 IPR033247 Transketolase family SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 Pfam PF02779 Transketolase, pyrimidine binding domain 18 174 1.0E-28 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 SUPERFAMILY SSF52922 187 321 1.3E-28 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 Pfam PF02780 Transketolase, C-terminal domain 190 309 4.4E-26 T 21-04-2016 IPR033248 Transketolase, C-terminal domain SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 SUPERFAMILY SSF52518 16 179 8.57E-43 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 PANTHER PTHR11624:SF2 17 323 7.1E-83 T 21-04-2016 SPH21_RS12980 9ea80d8289732b7bef8783ebcfef4aa0 324 SMART SM00861 13 178 1.9E-35 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS22075 b7df8be360f575891ed9d8b44f20d766 458 PANTHER PTHR10342 1 446 3.6E-126 T 21-04-2016 SPH21_RS22075 b7df8be360f575891ed9d8b44f20d766 458 ProSitePatterns PS00523 Sulfatases signature 1. 72 84 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS22075 b7df8be360f575891ed9d8b44f20d766 458 Pfam PF00884 Sulfatase 26 340 1.9E-57 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS22075 b7df8be360f575891ed9d8b44f20d766 458 PANTHER PTHR10342:SF199 1 446 3.6E-126 T 21-04-2016 SPH21_RS22075 b7df8be360f575891ed9d8b44f20d766 458 SUPERFAMILY SSF53649 24 446 9.03E-110 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS22075 b7df8be360f575891ed9d8b44f20d766 458 Gene3D G3DSA:3.30.1120.10 365 454 1.7E-17 T 21-04-2016 SPH21_RS22075 b7df8be360f575891ed9d8b44f20d766 458 Gene3D G3DSA:3.40.720.10 23 363 6.2E-93 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS08460 9ace057829306bf249867ed3747db328 235 Gene3D G3DSA:3.40.50.300 2 215 3.5E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08460 9ace057829306bf249867ed3747db328 235 SMART SM00382 27 206 2.0E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS08460 9ace057829306bf249867ed3747db328 235 SUPERFAMILY SSF52540 3 215 1.78E-56 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08460 9ace057829306bf249867ed3747db328 235 PANTHER PTHR24220:SF523 4 216 3.9E-85 T 21-04-2016 SPH21_RS08460 9ace057829306bf249867ed3747db328 235 Pfam PF00005 ABC transporter 19 160 1.4E-31 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS08460 9ace057829306bf249867ed3747db328 235 PANTHER PTHR24220 4 216 3.9E-85 T 21-04-2016 SPH21_RS07650 f9a94d59ff2b42e37d0b457ef5f5c320 264 Gene3D G3DSA:1.10.575.10 24 263 2.7E-62 T 21-04-2016 IPR008947 Phospholipase C/P1 nuclease domain GO:0016788 SPH21_RS07650 f9a94d59ff2b42e37d0b457ef5f5c320 264 Pfam PF02265 S1/P1 Nuclease 24 263 6.3E-60 T 21-04-2016 IPR003154 S1/P1 nuclease GO:0003676|GO:0004519|GO:0006308 SPH21_RS07650 f9a94d59ff2b42e37d0b457ef5f5c320 264 PANTHER PTHR33146 1 263 2.9E-40 T 21-04-2016 SPH21_RS07650 f9a94d59ff2b42e37d0b457ef5f5c320 264 SUPERFAMILY SSF48537 24 262 1.27E-54 T 21-04-2016 IPR008947 Phospholipase C/P1 nuclease domain GO:0016788 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 Pfam PF12838 4Fe-4S dicluster domain 9 91 4.1E-8 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 Gene3D G3DSA:3.30.70.20 5 28 5.4E-16 T 21-04-2016 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 Gene3D G3DSA:3.30.70.20 63 107 5.4E-16 T 21-04-2016 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 SUPERFAMILY SSF54862 5 29 1.48E-14 T 21-04-2016 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 SUPERFAMILY SSF54862 64 102 1.48E-14 T 21-04-2016 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 PANTHER PTHR24960 64 110 1.9E-17 T 21-04-2016 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 PANTHER PTHR24960 1 44 1.9E-17 T 21-04-2016 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 9 20 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 PANTHER PTHR24960:SF38 64 110 1.9E-17 T 21-04-2016 SPH21_RS14940 e52b9ad2073f86d96e054a7b89351a54 117 PANTHER PTHR24960:SF38 1 44 1.9E-17 T 21-04-2016 SPH21_RS09295 32ddbffa4e1d464c93e81ca8bd64a816 526 Gene3D G3DSA:1.25.40.10 196 295 1.0E-44 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09295 32ddbffa4e1d464c93e81ca8bd64a816 526 Gene3D G3DSA:1.25.40.10 357 450 1.0E-44 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09295 32ddbffa4e1d464c93e81ca8bd64a816 526 Pfam PF14322 Starch-binding associating with outer membrane 25 216 4.5E-20 T 21-04-2016 SPH21_RS09295 32ddbffa4e1d464c93e81ca8bd64a816 526 SUPERFAMILY SSF48452 20 526 5.69E-130 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09295 32ddbffa4e1d464c93e81ca8bd64a816 526 Pfam PF07980 SusD family 268 526 4.3E-52 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS15655 7058dd21eb0bced1541742caba4502b6 111 Pfam PF13411 MerR HTH family regulatory protein 13 82 5.6E-22 T 21-04-2016 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SPH21_RS15655 7058dd21eb0bced1541742caba4502b6 111 PANTHER PTHR30204 5 111 1.4E-21 T 21-04-2016 SPH21_RS15655 7058dd21eb0bced1541742caba4502b6 111 SMART SM00422 13 83 2.7E-8 T 21-04-2016 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SPH21_RS15655 7058dd21eb0bced1541742caba4502b6 111 PANTHER PTHR30204:SF15 5 111 1.4E-21 T 21-04-2016 SPH21_RS15655 7058dd21eb0bced1541742caba4502b6 111 Gene3D G3DSA:1.10.1660.10 13 110 5.7E-19 T 21-04-2016 SPH21_RS15655 7058dd21eb0bced1541742caba4502b6 111 SUPERFAMILY SSF46955 13 109 4.26E-18 T 21-04-2016 IPR009061 Putative DNA-binding domain SPH21_RS05250 2b34e4e81e001e55bf30799175bb0f40 415 Pfam PF02687 FtsX-like permease family 295 408 3.0E-21 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05250 2b34e4e81e001e55bf30799175bb0f40 415 PANTHER PTHR30572 5 415 1.0E-72 T 21-04-2016 SPH21_RS05250 2b34e4e81e001e55bf30799175bb0f40 415 Pfam PF12704 MacB-like periplasmic core domain 25 239 1.3E-27 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 PANTHER PTHR11532:SF57 383 434 6.3E-225 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 PANTHER PTHR11532:SF57 506 1031 6.3E-225 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 PANTHER PTHR11532:SF57 1 366 6.3E-225 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 25 1033 5.7E-240 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 PANTHER PTHR11532 383 434 6.3E-225 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 PANTHER PTHR11532 506 1031 6.3E-225 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 PANTHER PTHR11532 1 366 6.3E-225 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 Pfam PF07715 TonB-dependent Receptor Plug Domain 117 221 3.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 Pfam PF13715 CarboxypepD_reg-like domain 26 108 4.6E-18 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 Gene3D G3DSA:2.170.130.10 111 224 5.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 SUPERFAMILY SSF56935 104 244 6.96E-86 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 SUPERFAMILY SSF56935 947 1033 6.96E-86 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 SUPERFAMILY SSF56935 841 885 6.96E-86 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 SUPERFAMILY SSF56935 312 400 6.96E-86 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 SUPERFAMILY SSF56935 437 775 6.96E-86 T 21-04-2016 SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 Gene3D G3DSA:2.60.40.1120 26 110 7.1E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 SUPERFAMILY SSF49464 25 106 1.7E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14360 7a1f5c4294e674226ef44a51836f5deb 1033 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 197 227 2.5E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13560 5381724baa73aeae8398c6a45a23fc99 677 SUPERFAMILY SSF55874 22 168 4.32E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13560 5381724baa73aeae8398c6a45a23fc99 677 Gene3D G3DSA:3.30.565.10 20 212 1.1E-17 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13560 5381724baa73aeae8398c6a45a23fc99 677 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 22 145 2.3E-17 T 21-04-2016 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 SUPERFAMILY SSF52335 7 197 3.21E-59 T 21-04-2016 IPR011607 Methylglyoxal synthase-like domain SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 Gene3D G3DSA:3.40.140.20 356 498 5.4E-47 T 21-04-2016 IPR024051 AICAR transformylase domain KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 PANTHER PTHR11692:SF2 5 508 2.9E-244 T 21-04-2016 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 SMART SM00798 138 440 1.6E-146 T 21-04-2016 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 PIRSF PIRSF000414 1 508 1.2E-189 T 21-04-2016 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 Hamap MF_00139 Bifunctional purine biosynthesis protein PurH [purH]. 7 508 38.369 T 21-04-2016 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 PANTHER PTHR11692 5 508 2.9E-244 T 21-04-2016 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 Gene3D G3DSA:3.40.140.20 235 348 3.8E-40 T 21-04-2016 IPR024051 AICAR transformylase domain KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 SMART SM00851 19 133 1.0E-42 T 21-04-2016 IPR011607 Methylglyoxal synthase-like domain SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 SUPERFAMILY SSF53927 210 508 1.3E-110 T 21-04-2016 IPR016193 Cytidine deaminase-like GO:0003824 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 Pfam PF02142 MGS-like domain 22 132 1.3E-20 T 21-04-2016 IPR011607 Methylglyoxal synthase-like domain SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 TIGRFAM TIGR00355 purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 8 508 1.0E-162 T 21-04-2016 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 Gene3D G3DSA:3.40.50.1380 6 191 1.0E-68 T 21-04-2016 IPR011607 Methylglyoxal synthase-like domain SPH21_RS11760 a265c9065326886fb50d855191d1e2a8 508 Pfam PF01808 AICARFT/IMPCHase bienzyme 138 439 1.7E-101 T 21-04-2016 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074|UniPathway: UPA00074 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 Hamap MF_00001 Aspartate carbamoyltransferase [pyrB]. 10 310 39.536 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 11 154 3.6E-37 T 21-04-2016 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PANTHER PTHR11405:SF16 5 311 1.9E-133 T 21-04-2016 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 ProSitePatterns PS00097 Aspartate and ornithine carbamoyltransferases signature. 57 64 - T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PANTHER PTHR11405 5 311 1.9E-133 T 21-04-2016 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 Gene3D G3DSA:3.40.50.1370 149 295 1.2E-44 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 SUPERFAMILY SSF53671 8 310 7.59E-95 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 TIGRFAM TIGR00670 asp_carb_tr: aspartate carbamoyltransferase 11 307 6.2E-97 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 261 270 3.8E-21 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 273 296 3.8E-21 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 57 76 3.8E-21 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 141 152 3.8E-21 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00101 Aspartate carbamoyltransferase signature 224 233 1.2E-30 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00101 Aspartate carbamoyltransferase signature 289 303 1.2E-30 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00101 Aspartate carbamoyltransferase signature 47 69 1.2E-30 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00101 Aspartate carbamoyltransferase signature 140 157 1.2E-30 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00101 Aspartate carbamoyltransferase signature 85 94 1.2E-30 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 PRINTS PR00101 Aspartate carbamoyltransferase signature 265 270 1.2E-30 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 161 307 3.0E-23 T 21-04-2016 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 SPH21_RS10975 17497401f0c5eeaebf4ec886d0f1e7ad 312 Gene3D G3DSA:3.40.50.1370 7 148 1.6E-48 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 SUPERFAMILY SSF141734 4 109 1.44E-44 T 21-04-2016 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 Hamap MF_01019 Histidine biosynthesis bifunctional protein HisIE [hisI]. 2 194 33.336 T 21-04-2016 IPR023019 Histidine biosynthesis bifunctional protein HisIE GO:0000105|GO:0004635|GO:0004636 KEGG: 00340+3.6.1.31+3.5.4.19|UniPathway: UPA00031|UniPathway: UPA00031 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 Pfam PF01502 Phosphoribosyl-AMP cyclohydrolase 25 98 4.8E-32 T 21-04-2016 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19|UniPathway: UPA00031 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 ProDom PD002610 PHOSPHORIBOSYL-AMP BIOSYNTHESIS CYCLOHYDROLASE HYDROLASE HISTIDINE AMINO-ACID PRA-CH PHOSPHORIBOSYL-ATP BIFUNCTIONAL INCLUDES: 48 97 1.0E-18 T 21-04-2016 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19|UniPathway: UPA00031 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 PANTHER PTHR21256 2 195 1.7E-94 T 21-04-2016 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 SUPERFAMILY SSF101386 105 193 2.18E-21 T 21-04-2016 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 TIGRFAM TIGR03188 histidine_hisI: phosphoribosyl-ATP diphosphatase 108 189 7.0E-27 T 21-04-2016 IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase GO:0000105|GO:0004636 KEGG: 00340+3.6.1.31|UniPathway: UPA00031 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 Hamap MF_01020 Phosphoribosyl-ATP pyrophosphatase [hisE]. 103 189 17.442 T 21-04-2016 IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase GO:0000105|GO:0004636 KEGG: 00340+3.6.1.31|UniPathway: UPA00031 SPH21_RS25340 51061ac4dcb6b544ae0e7c18264687d5 195 Pfam PF01503 Phosphoribosyl-ATP pyrophosphohydrolase 108 193 6.7E-12 T 21-04-2016 IPR021130 Phosphoribosyl-ATP pyrophosphohydrolase-like KEGG: 00340+3.6.1.31|UniPathway: UPA00031 SPH21_RS07670 fdf1ae91194f70180a9dbd4649487a43 492 PANTHER PTHR34856 30 481 1.3E-219 T 21-04-2016 SPH21_RS07670 fdf1ae91194f70180a9dbd4649487a43 492 Pfam PF03916 Polysulphide reductase, NrfD 72 395 2.4E-19 T 21-04-2016 IPR005614 NrfD family SPH21_RS07670 fdf1ae91194f70180a9dbd4649487a43 492 PANTHER PTHR34856:SF1 30 481 1.3E-219 T 21-04-2016 SPH21_RS13470 fdb0aa9a584815c553ea57da09e1eff0 127 PRINTS PR00502 NUDIX hydrolase family signature 34 48 4.5E-5 T 21-04-2016 IPR020476 NUDIX hydrolase SPH21_RS13470 fdb0aa9a584815c553ea57da09e1eff0 127 PRINTS PR00502 NUDIX hydrolase family signature 48 63 4.5E-5 T 21-04-2016 IPR020476 NUDIX hydrolase SPH21_RS13470 fdb0aa9a584815c553ea57da09e1eff0 127 PANTHER PTHR22769 1 127 8.5E-26 T 21-04-2016 SPH21_RS13470 fdb0aa9a584815c553ea57da09e1eff0 127 Pfam PF00293 NUDIX domain 2 125 1.8E-11 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS13470 fdb0aa9a584815c553ea57da09e1eff0 127 SUPERFAMILY SSF55811 1 127 3.38E-27 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS13470 fdb0aa9a584815c553ea57da09e1eff0 127 PANTHER PTHR22769:SF35 1 127 8.5E-26 T 21-04-2016 SPH21_RS13470 fdb0aa9a584815c553ea57da09e1eff0 127 Gene3D G3DSA:3.90.79.10 3 124 1.3E-24 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 Gene3D G3DSA:3.50.50.60 113 341 4.2E-26 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 107 125 2.0E-11 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 167 185 2.0E-11 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 289 311 2.0E-11 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 16 35 2.0E-11 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PANTHER PTHR10632 1 120 3.5E-19 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 Gene3D G3DSA:3.50.50.60 11 112 6.0E-22 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 SUPERFAMILY SSF51905 14 189 3.24E-31 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 15 37 1.8E-10 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 167 192 1.8E-10 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 304 311 1.8E-10 T 21-04-2016 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 SUPERFAMILY SSF51905 168 341 4.51E-20 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24185 7e30fe7db38d117e628a03e10d58a3b1 439 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 15 334 8.5E-48 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS11495 dcf5f34a50c6a85317d3f70985038ecf 475 Gene3D G3DSA:1.25.40.10 329 420 1.8E-24 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11495 dcf5f34a50c6a85317d3f70985038ecf 475 Gene3D G3DSA:1.25.40.10 207 293 1.8E-24 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11495 dcf5f34a50c6a85317d3f70985038ecf 475 Pfam PF07980 SusD family 340 472 1.4E-24 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS11495 dcf5f34a50c6a85317d3f70985038ecf 475 SUPERFAMILY SSF48452 19 472 7.59E-99 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11495 dcf5f34a50c6a85317d3f70985038ecf 475 Pfam PF14322 Starch-binding associating with outer membrane 24 224 5.8E-23 T 21-04-2016 SPH21_RS08375 60e6213e1c726ba164c2ab64b2576619 623 PANTHER PTHR10342:SF236 242 555 5.0E-48 T 21-04-2016 SPH21_RS08375 60e6213e1c726ba164c2ab64b2576619 623 PIRSF PIRSF005091 1 591 8.4E-80 T 21-04-2016 IPR012160 Lipoteichoic acid synthase-like KEGG: 00440+2.7.8.-|KEGG: 00513+2.7.8.-|KEGG: 00540+2.7.8.-|KEGG: 00564+2.7.8.-|KEGG: 00600+2.7.8.-|KEGG: 00770+2.7.8.-|UniPathway: UPA00556 SPH21_RS08375 60e6213e1c726ba164c2ab64b2576619 623 Gene3D G3DSA:3.40.720.10 269 555 1.1E-30 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS08375 60e6213e1c726ba164c2ab64b2576619 623 SUPERFAMILY SSF53649 267 584 5.23E-47 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS08375 60e6213e1c726ba164c2ab64b2576619 623 Pfam PF00884 Sulfatase 269 543 1.9E-29 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS08375 60e6213e1c726ba164c2ab64b2576619 623 PANTHER PTHR10342 242 555 5.0E-48 T 21-04-2016 SPH21_RS06325 89c08ec450a180de5108f9ca0a1d31d4 266 PANTHER PTHR13355 38 131 2.0E-16 T 21-04-2016 SPH21_RS06325 89c08ec450a180de5108f9ca0a1d31d4 266 Gene3D G3DSA:3.40.630.30 2 120 3.1E-18 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS06325 89c08ec450a180de5108f9ca0a1d31d4 266 Pfam PF00583 Acetyltransferase (GNAT) family 47 115 1.2E-10 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS06325 89c08ec450a180de5108f9ca0a1d31d4 266 SUPERFAMILY SSF55729 1 206 1.49E-23 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SUPERFAMILY SSF55874 412 497 1.57E-11 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Pfam PF13181 Tetratricopeptide repeat 87 113 0.024 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SUPERFAMILY SSF48452 125 253 2.77E-15 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Pfam PF13424 Tetratricopeptide repeat 12 74 1.9E-7 T 21-04-2016 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Gene3D G3DSA:3.30.565.10 399 548 1.0E-11 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Pfam PF13374 Tetratricopeptide repeat 123 154 0.0026 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 451 506 4.4E-5 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Gene3D G3DSA:1.25.40.10 60 140 2.5E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Gene3D G3DSA:1.25.40.10 141 258 7.9E-15 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Gene3D G3DSA:1.25.40.10 16 59 4.2E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SMART SM00028 86 119 1.1 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SMART SM00028 202 235 45.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SMART SM00028 123 156 0.25 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SMART SM00028 163 196 15.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SMART SM00028 46 79 40.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 PANTHER PTHR34220 310 518 1.1E-36 T 21-04-2016 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 Pfam PF06580 Histidine kinase 352 424 2.9E-16 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS03250 c2d68606fc3aa527d4596f8c0d2bd4e1 550 SUPERFAMILY SSF48452 16 152 3.22E-11 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 Hamap MF_00144 tRNA-specific 2-thiouridylase MnmA [mnmA]. 5 362 38.722 T 21-04-2016 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 PANTHER PTHR11933 1 360 8.4E-147 T 21-04-2016 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 PANTHER PTHR11933:SF10 1 360 8.4E-147 T 21-04-2016 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 Pfam PF03054 tRNA methyl transferase 6 360 1.9E-106 T 21-04-2016 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 Gene3D G3DSA:3.40.50.620 2 216 2.2E-80 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 Gene3D G3DSA:2.40.30.10 284 361 1.5E-16 T 21-04-2016 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 TIGRFAM TIGR00420 trmU: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 6 360 2.6E-93 T 21-04-2016 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 Gene3D G3DSA:2.30.30.280 229 282 1.0E-14 T 21-04-2016 IPR023382 Adenine nucleotide alpha hydrolase-like domains GO:0016783 SPH21_RS15810 aa64cfe806f9153b4ae9a640958adbf7 362 SUPERFAMILY SSF52402 2 254 2.87E-53 T 21-04-2016 SPH21_RS25420 d85b013d90797249650ea772b3cc76bc 116 TIGRFAM TIGR00621 ssb: single-stranded DNA-binding protein 6 111 2.1E-30 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS25420 d85b013d90797249650ea772b3cc76bc 116 Hamap MF_00984 Single-stranded DNA-binding protein. 5 112 24.927 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS25420 d85b013d90797249650ea772b3cc76bc 116 Pfam PF00436 Single-strand binding protein family 6 107 8.3E-30 T 21-04-2016 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 SPH21_RS25420 d85b013d90797249650ea772b3cc76bc 116 SUPERFAMILY SSF50249 6 113 1.66E-33 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS25420 d85b013d90797249650ea772b3cc76bc 116 PANTHER PTHR10302 6 109 2.0E-29 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS25420 d85b013d90797249650ea772b3cc76bc 116 Gene3D G3DSA:2.40.50.140 3 110 7.5E-35 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS25420 d85b013d90797249650ea772b3cc76bc 116 PIRSF PIRSF002070 1 116 3.6E-30 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Pfam PF13432 Tetratricopeptide repeat 579 633 2.8E-4 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SUPERFAMILY SSF48452 312 534 3.42E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Gene3D G3DSA:1.25.40.10 577 693 1.2E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SUPERFAMILY SSF81901 272 377 1.36E-8 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SUPERFAMILY SSF81901 127 225 1.36E-8 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SUPERFAMILY SSF48452 577 747 4.91E-14 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Gene3D G3DSA:1.25.40.10 369 539 3.6E-17 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Gene3D G3DSA:1.25.40.10 275 368 2.8E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SMART SM00028 646 678 81.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SMART SM00028 390 423 54.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SMART SM00028 795 828 31.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SMART SM00028 350 383 340.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SMART SM00028 499 532 4.2 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SMART SM00028 757 790 97.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Gene3D G3DSA:1.25.40.10 83 274 1.3E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Gene3D G3DSA:1.25.40.10 767 829 6.0E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Gene3D G3DSA:1.25.40.10 694 766 1.4E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 PANTHER PTHR23083 2 14 3.8E-23 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 PANTHER PTHR23083 791 843 3.8E-23 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 PANTHER PTHR23083 583 750 3.8E-23 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 PANTHER PTHR23083 304 542 3.8E-23 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 PANTHER PTHR23083 90 187 3.8E-23 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Pfam PF13174 Tetratricopeptide repeat 394 419 0.033 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Pfam PF13174 Tetratricopeptide repeat 800 825 0.12 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Pfam PF13174 Tetratricopeptide repeat 758 786 0.12 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 Pfam PF13525 Outer membrane lipoprotein 446 544 2.1E-9 T 21-04-2016 SPH21_RS24700 9db2e27c0b007bd56532f5892592c947 845 SUPERFAMILY SSF48452 718 832 8.67E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 PRINTS PR00061 Ribosomal protein L19 signature 88 113 7.9E-35 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 PRINTS PR00061 Ribosomal protein L19 signature 4 33 7.9E-35 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 PRINTS PR00061 Ribosomal protein L19 signature 34 63 7.9E-35 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 PANTHER PTHR15680 2 114 1.4E-46 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 Pfam PF01245 Ribosomal protein L19 4 112 1.9E-47 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 PIRSF PIRSF002191 1 115 6.6E-49 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 SUPERFAMILY SSF50104 2 113 6.62E-43 T 21-04-2016 IPR008991 Translation protein SH3-like domain SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 Hamap MF_00402 50S ribosomal protein L19 [rplS]. 1 114 28.488 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 TIGRFAM TIGR01024 rplS_bact: ribosomal protein bL19 1 113 8.3E-47 T 21-04-2016 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06535 38d4a1f8c21bb51ba82aef6f6b783ddd 115 ProSitePatterns PS01015 Ribosomal protein L19 signature. 86 101 - T 21-04-2016 IPR018257 Ribosomal protein L19, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 Gene3D G3DSA:2.60.120.10 60 192 2.3E-24 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 PANTHER PTHR10245:SF49 7 185 5.6E-26 T 21-04-2016 SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 PANTHER PTHR10245 7 185 5.6E-26 T 21-04-2016 SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 Pfam PF07883 Cupin domain 131 186 4.1E-10 T 21-04-2016 IPR013096 Cupin 2, conserved barrel SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 Pfam PF01381 Helix-turn-helix 13 65 8.7E-13 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 SUPERFAMILY SSF47413 3 72 1.85E-17 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 SUPERFAMILY SSF51182 60 187 2.65E-19 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 SMART SM00530 12 67 1.2E-12 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01060 0f9d442c62e43ed1da2505fe913ff8c3 193 Gene3D G3DSA:1.10.260.40 2 59 5.6E-19 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 SUPERFAMILY SSF53300 223 417 4.32E-35 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 Pfam PF12034 Domain of unknown function (DUF3520) 427 611 1.5E-70 T 21-04-2016 IPR021908 Protein of unknown function DUF3520 SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 SUPERFAMILY SSF49464 23 99 2.49E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 Gene3D G3DSA:3.40.50.410 248 419 9.8E-26 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 Pfam PF13715 CarboxypepD_reg-like domain 25 104 9.2E-13 T 21-04-2016 SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 Pfam PF00092 von Willebrand factor type A domain 251 415 1.6E-21 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 Gene3D G3DSA:2.60.40.1120 24 97 9.3E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 PANTHER PTHR10166:SF15 248 523 8.9E-104 T 21-04-2016 SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 PANTHER PTHR10166 248 523 8.9E-104 T 21-04-2016 SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 Pfam PF12450 von Willebrand factor 143 234 4.5E-40 T 21-04-2016 IPR022156 Uncharacterised protein YfbK, N-terminal SPH21_RS03195 5fe13643dccc0c9b164fdba82e65c99e 622 SMART SM00327 249 424 6.4E-29 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 SMART SM00322 59 124 3.8E-10 T 21-04-2016 IPR004087 K Homology domain GO:0003676 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 PANTHER PTHR11760 2 212 2.2E-126 T 21-04-2016 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 Gene3D G3DSA:3.30.300.20 18 106 1.8E-31 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 SUPERFAMILY SSF54814 2 105 3.14E-35 T 21-04-2016 IPR009019 K homology domain, prokaryotic type GO:0003723 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 ProSitePatterns PS00548 Ribosomal protein S3 signature. 162 196 - T 21-04-2016 IPR018280 Ribosomal protein S3, conserved site SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 Pfam PF07650 KH domain 37 110 3.2E-20 T 21-04-2016 IPR004044 K Homology domain, type 2 GO:0003723 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 Pfam PF00189 Ribosomal protein S3, C-terminal domain 119 201 1.6E-40 T 21-04-2016 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 SUPERFAMILY SSF54821 106 205 1.7E-39 T 21-04-2016 IPR001351 Ribosomal protein S3, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 Gene3D G3DSA:3.30.1140.32 108 206 2.3E-45 T 21-04-2016 IPR001351 Ribosomal protein S3, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 TIGRFAM TIGR01009 rpsC_bact: ribosomal protein uS3 1 209 1.1E-90 T 21-04-2016 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 PANTHER PTHR11760:SF19 2 212 2.2E-126 T 21-04-2016 SPH21_RS08525 0ae35d71a2d15db82fff181bf2f3dbb2 267 Hamap MF_01309_B 30S ribosomal protein S3 [rpsC]. 1 205 36.972 T 21-04-2016 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 Pfam PF10417 C-terminal domain of 1-Cys peroxiredoxin 156 194 3.7E-10 T 21-04-2016 IPR019479 Peroxiredoxin, C-terminal GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 Gene3D G3DSA:3.40.30.10 4 157 3.0E-62 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 Gene3D G3DSA:3.30.1020.10 158 210 4.9E-28 T 21-04-2016 SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 PANTHER PTHR10681 3 206 8.4E-93 T 21-04-2016 SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 Pfam PF00578 AhpC/TSA family 6 134 2.1E-32 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 PIRSF PIRSF000239 1 208 1.8E-80 T 21-04-2016 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15 SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 SUPERFAMILY SSF52833 3 208 2.88E-70 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS19220 1d3f00a12c957dad5c34d1e8841c8d1b 211 PANTHER PTHR10681:SF99 3 206 8.4E-93 T 21-04-2016 SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 PANTHER PTHR10804:SF17 374 461 1.6E-104 T 21-04-2016 SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 PANTHER PTHR10804:SF17 7 356 1.6E-104 T 21-04-2016 SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 Pfam PF05195 Aminopeptidase P, N-terminal domain 7 122 5.0E-25 T 21-04-2016 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 PANTHER PTHR10804 374 461 1.6E-104 T 21-04-2016 SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 PANTHER PTHR10804 7 356 1.6E-104 T 21-04-2016 SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 SMART SM01011 2 134 8.5E-30 T 21-04-2016 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 Pfam PF00557 Metallopeptidase family M24 175 439 5.5E-44 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 SUPERFAMILY SSF53092 2 167 1.94E-32 T 21-04-2016 IPR028980 Creatinase/Aminopeptidase P, N-terminal SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 Gene3D G3DSA:3.40.350.10 2 170 1.9E-32 T 21-04-2016 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 Gene3D G3DSA:3.90.230.10 171 459 4.6E-58 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS04870 e3948ccd19ded1181f1786eec48eb364 463 SUPERFAMILY SSF55920 168 458 4.97E-53 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS16700 257a3f0ada8745bac4beff0a81d34835 98 SUPERFAMILY SSF54913 2 97 1.56E-19 T 21-04-2016 IPR011322 Nitrogen regulatory PII-like, alpha/beta SPH21_RS16700 257a3f0ada8745bac4beff0a81d34835 98 Pfam PF02641 Uncharacterized ACR, COG1993 5 97 1.8E-21 T 21-04-2016 IPR003793 Domain of unknown function DUF190 SPH21_RS16700 257a3f0ada8745bac4beff0a81d34835 98 Gene3D G3DSA:3.30.70.120 5 96 6.9E-20 T 21-04-2016 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal SPH21_RS12065 355c049a5b81789bfde5f933337e7284 739 SUPERFAMILY SSF53756 378 736 3.92E-27 T 21-04-2016 SPH21_RS12065 355c049a5b81789bfde5f933337e7284 739 PANTHER PTHR22916:SF26 56 363 1.0E-41 T 21-04-2016 SPH21_RS12065 355c049a5b81789bfde5f933337e7284 739 Gene3D G3DSA:3.90.550.10 109 356 4.4E-53 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12065 355c049a5b81789bfde5f933337e7284 739 SUPERFAMILY SSF53448 106 350 2.69E-46 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12065 355c049a5b81789bfde5f933337e7284 739 Pfam PF13692 Glycosyl transferases group 1 569 704 3.9E-21 T 21-04-2016 SPH21_RS12065 355c049a5b81789bfde5f933337e7284 739 Pfam PF00535 Glycosyl transferase family 2 112 229 1.6E-23 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS12065 355c049a5b81789bfde5f933337e7284 739 PANTHER PTHR22916 56 363 1.0E-41 T 21-04-2016 SPH21_RS10385 d069f0583cf84fb5f5c5958c671cf89c 192 SUPERFAMILY SSF55811 9 190 4.2E-42 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS10385 d069f0583cf84fb5f5c5958c671cf89c 192 TIGRFAM TIGR00052 TIGR00052: nudix-type nucleoside diphosphatase, YffH/AdpP family 7 188 4.4E-49 T 21-04-2016 IPR004385 Nucleoside diphosphate pyrophosphatase GO:0016818|GO:0046872 SPH21_RS10385 d069f0583cf84fb5f5c5958c671cf89c 192 Gene3D G3DSA:3.90.79.10 4 189 9.1E-53 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS10385 d069f0583cf84fb5f5c5958c671cf89c 192 Pfam PF00293 NUDIX domain 45 152 1.1E-10 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS10385 d069f0583cf84fb5f5c5958c671cf89c 192 PANTHER PTHR11839 12 188 9.2E-43 T 21-04-2016 SPH21_RS02540 8d7b1bacb802e070a6e12f1040754559 424 PANTHER PTHR30268 10 417 1.0E-93 T 21-04-2016 SPH21_RS02540 8d7b1bacb802e070a6e12f1040754559 424 ProDom PD042532 ISOMERASE L-RHAMNOSE METAL-BINDING METABOLISM RHAMNOSE MANGANESE ENZYME KINASE 3D-STRUCTURE RHAA/RHAB 100 379 0.006 T 21-04-2016 SPH21_RS02540 8d7b1bacb802e070a6e12f1040754559 424 Gene3D G3DSA:3.20.20.150 43 404 7.8E-76 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS02540 8d7b1bacb802e070a6e12f1040754559 424 SUPERFAMILY SSF51658 43 403 7.9E-80 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Gene3D G3DSA:2.60.40.1120 42 132 5.5E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Pfam PF00593 TonB dependent receptor 604 1028 7.5E-19 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 PANTHER PTHR11532 395 428 3.7E-265 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 PANTHER PTHR11532 18 379 3.7E-265 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 PANTHER PTHR11532 504 1028 3.7E-265 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Pfam PF07715 TonB-dependent Receptor Plug Domain 132 236 1.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 SUPERFAMILY SSF56935 854 898 5.04E-91 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 SUPERFAMILY SSF56935 307 394 5.04E-91 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 SUPERFAMILY SSF56935 431 774 5.04E-91 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 SUPERFAMILY SSF56935 936 1030 5.04E-91 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 SUPERFAMILY SSF56935 119 260 5.04E-91 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 PANTHER PTHR11532:SF57 395 428 3.7E-265 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 PANTHER PTHR11532:SF57 18 379 3.7E-265 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 PANTHER PTHR11532:SF57 504 1028 3.7E-265 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Gene3D G3DSA:2.170.130.10 133 239 2.7E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Pfam PF13715 CarboxypepD_reg-like domain 42 123 5.1E-16 T 21-04-2016 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 41 1030 2.4E-268 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 212 242 6.2E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Gene3D G3DSA:2.40.170.20 316 391 2.2E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Gene3D G3DSA:2.40.170.20 426 783 2.2E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Gene3D G3DSA:2.40.170.20 240 260 2.2E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 Gene3D G3DSA:2.40.170.20 863 1030 2.2E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25045 50f481d324dc06be89266bfc133b27c9 1030 SUPERFAMILY SSF49464 40 121 2.49E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 Pfam PF16188 C-terminal region of peptidase_M24 532 590 7.3E-21 T 21-04-2016 IPR032416 Peptidase M24, C-terminal domain SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 PANTHER PTHR10804 5 181 6.0E-161 T 21-04-2016 SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 PANTHER PTHR10804 282 590 6.0E-161 T 21-04-2016 SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 Pfam PF01321 Creatinase/Prolidase N-terminal domain 7 133 4.9E-17 T 21-04-2016 IPR000587 Creatinase, N-terminal GO:0016787 SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 Gene3D G3DSA:3.90.230.10 303 557 9.7E-53 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 Pfam PF00557 Metallopeptidase family M24 311 521 2.3E-42 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 Pfam PF16189 Creatinase/Prolidase N-terminal domain 149 307 4.1E-44 T 21-04-2016 SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 Gene3D G3DSA:3.40.350.10 170 283 1.8E-9 T 21-04-2016 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 Gene3D G3DSA:3.40.350.10 3 131 4.4E-22 T 21-04-2016 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 PANTHER PTHR10804:SF87 5 181 6.0E-161 T 21-04-2016 SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 PANTHER PTHR10804:SF87 282 590 6.0E-161 T 21-04-2016 SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 SUPERFAMILY SSF55920 304 556 2.75E-48 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS17640 3edfddd2d7b24e4729db7092719d82ed 592 SUPERFAMILY SSF53092 10 130 1.27E-11 T 21-04-2016 IPR028980 Creatinase/Aminopeptidase P, N-terminal SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 PRINTS PR01033 Phytochrome signature 423 442 1.283297E-14 T 21-04-2016 IPR001294 Phytochrome GO:0006355|GO:0009584 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 PRINTS PR01033 Phytochrome signature 240 261 1.283297E-14 T 21-04-2016 IPR001294 Phytochrome GO:0006355|GO:0009584 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 PRINTS PR01033 Phytochrome signature 338 358 1.283297E-14 T 21-04-2016 IPR001294 Phytochrome GO:0006355|GO:0009584 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 PRINTS PR01033 Phytochrome signature 457 475 1.283297E-14 T 21-04-2016 IPR001294 Phytochrome GO:0006355|GO:0009584 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 PRINTS PR01033 Phytochrome signature 153 172 1.283297E-14 T 21-04-2016 IPR001294 Phytochrome GO:0006355|GO:0009584 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 PANTHER PTHR24423:SF518 153 313 6.8E-37 T 21-04-2016 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 SUPERFAMILY SSF55785 2 113 3.07E-21 T 21-04-2016 IPR000014 PAS domain SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 Pfam PF08446 PAS fold 13 112 1.1E-10 T 21-04-2016 IPR013654 PAS fold-2 GO:0006355 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 SUPERFAMILY SSF55781 120 304 1.05E-50 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 SMART SM00065 138 312 7.7E-5 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 Pfam PF00360 Phytochrome region 319 497 1.6E-47 T 21-04-2016 IPR013515 Phytochrome, central region GO:0006355|GO:0009584|GO:0018298 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 Pfam PF01590 GAF domain 138 301 2.7E-13 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 PANTHER PTHR24423 153 313 6.8E-37 T 21-04-2016 SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 SUPERFAMILY SSF55781 319 499 2.55E-47 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS10620 90ddea5247dc7f6387dd766f858f9fb2 500 Gene3D G3DSA:3.30.450.40 121 299 1.9E-10 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 PANTHER PTHR30027 1 233 7.3E-48 T 21-04-2016 SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 TIGRFAM TIGR00046 TIGR00046: RNA methyltransferase, RsmE family 2 232 7.0E-42 T 21-04-2016 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 PIRSF PIRSF015601 1 236 4.9E-53 T 21-04-2016 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 Gene3D G3DSA:3.40.1280.10 2 234 2.3E-65 T 21-04-2016 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 Pfam PF04452 RNA methyltransferase 17 229 2.7E-56 T 21-04-2016 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 SUPERFAMILY SSF75217 75 232 4.55E-41 T 21-04-2016 IPR029028 Alpha/beta knot methyltransferases SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 PANTHER PTHR30027:SF3 1 233 7.3E-48 T 21-04-2016 SPH21_RS07940 3a04c18364afb5dbf0b3775dabd49291 236 SUPERFAMILY SSF88697 2 68 3.81E-12 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 Pfam PF00814 Glycoprotease family 23 307 4.8E-100 T 21-04-2016 IPR000905 Gcp-like domain KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 SUPERFAMILY SSF53067 4 121 1.94E-28 T 21-04-2016 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 SUPERFAMILY SSF53067 100 310 2.73E-41 T 21-04-2016 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 Hamap MF_01445 tRNA N6-adenosine threonylcarbamoyltransferase [tsaD]. 2 332 62.006 T 21-04-2016 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 96 115 2.0E-46 T 21-04-2016 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 5 18 2.0E-46 T 21-04-2016 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 75 95 2.0E-46 T 21-04-2016 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 264 273 2.0E-46 T 21-04-2016 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 130 142 2.0E-46 T 21-04-2016 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 153 174 2.0E-46 T 21-04-2016 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 Gene3D G3DSA:3.30.420.40 3 158 1.2E-43 T 21-04-2016 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 TIGRFAM TIGR03723 T6A_TsaD_YgjD: tRNA threonylcarbamoyl adenosine modification protein TsaD 4 314 7.0E-125 T 21-04-2016 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PANTHER PTHR11735:SF6 3 330 2.6E-140 T 21-04-2016 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 PANTHER PTHR11735 3 330 2.6E-140 T 21-04-2016 SPH21_RS02800 2b1737e74aa7cc2cafc81721859f7b66 334 TIGRFAM TIGR00329 gcp_kae1: metallohydrolase, glycoprotease/Kae1 family 5 307 6.1E-106 T 21-04-2016 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00473 Galactokinase signature 26 44 4.6E-21 T 21-04-2016 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00473 Galactokinase signature 109 127 4.6E-21 T 21-04-2016 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00473 Galactokinase signature 88 99 4.6E-21 T 21-04-2016 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00473 Galactokinase signature 266 280 4.6E-21 T 21-04-2016 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 ProSitePatterns PS00106 Galactokinase signature. 26 37 - T 21-04-2016 IPR019741 Galactokinase, conserved site KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 Gene3D G3DSA:3.30.230.10 5 205 1.7E-69 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 Gene3D G3DSA:3.30.70.890 206 381 7.9E-50 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 TIGRFAM TIGR00131 gal_kin: galactokinase 6 381 2.9E-104 T 21-04-2016 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 ProSitePatterns PS00627 GHMP kinases putative ATP-binding domain. 118 129 - T 21-04-2016 IPR006203 GHMP kinase, ATP-binding, conserved site GO:0005524 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PANTHER PTHR10457 5 388 8.4E-124 T 21-04-2016 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00959 Mevalonate kinase family signature 330 347 4.3E-44 T 21-04-2016 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00959 Mevalonate kinase family signature 24 48 4.3E-44 T 21-04-2016 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00959 Mevalonate kinase family signature 116 138 4.3E-44 T 21-04-2016 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PRINTS PR00959 Mevalonate kinase family signature 159 178 4.3E-44 T 21-04-2016 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PIRSF PIRSF000530 1 386 5.2E-118 T 21-04-2016 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 Pfam PF10509 Galactokinase galactose-binding signature 10 56 5.1E-22 T 21-04-2016 IPR019539 Galactokinase galactose-binding domain KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 Pfam PF00288 GHMP kinases N terminal domain 111 179 1.6E-16 T 21-04-2016 IPR006204 GHMP kinase N-terminal domain GO:0005524 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 SUPERFAMILY SSF55060 203 383 8.22E-44 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 Pfam PF08544 GHMP kinases C terminal 283 363 1.4E-9 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 PANTHER PTHR10457:SF6 5 388 8.4E-124 T 21-04-2016 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 Hamap MF_00246 Galactokinase [galK]. 24 383 39.547 T 21-04-2016 IPR022963 Galactokinase, bacterial GO:0004335|GO:0006012 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527|UniPathway: UPA00214 SPH21_RS06640 46be178746d4663b8e8e10ebaf428f95 394 SUPERFAMILY SSF54211 5 199 1.59E-58 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS18280 4aea5e9b33c5ea5bd0a538e911320aac 202 PANTHER PTHR36122:SF1 1 199 2.2E-24 T 21-04-2016 SPH21_RS18280 4aea5e9b33c5ea5bd0a538e911320aac 202 PANTHER PTHR36122 1 199 2.2E-24 T 21-04-2016 SPH21_RS18280 4aea5e9b33c5ea5bd0a538e911320aac 202 Pfam PF04973 Nicotinamide mononucleotide transporter 17 194 2.2E-46 T 21-04-2016 IPR006419 Nicotinamide mononucleotide transporter PnuC GO:0016020|GO:0034257|GO:0034258 SPH21_RS18280 4aea5e9b33c5ea5bd0a538e911320aac 202 TIGRFAM TIGR01528 NMN_trans_PnuC: nicotinamide mononucleotide transporter PnuC 17 195 1.1E-27 T 21-04-2016 IPR006419 Nicotinamide mononucleotide transporter PnuC GO:0016020|GO:0034257|GO:0034258 SPH21_RS21850 ddf145f9f915c24c8f1956d0ce8e880d 489 SUPERFAMILY SSF50939 133 156 1.86E-11 T 21-04-2016 IPR011040 Sialidases SPH21_RS21850 ddf145f9f915c24c8f1956d0ce8e880d 489 SUPERFAMILY SSF50939 209 432 1.86E-11 T 21-04-2016 IPR011040 Sialidases SPH21_RS21850 ddf145f9f915c24c8f1956d0ce8e880d 489 Gene3D G3DSA:2.120.10.10 372 426 1.1E-6 T 21-04-2016 IPR011040 Sialidases SPH21_RS21850 ddf145f9f915c24c8f1956d0ce8e880d 489 Gene3D G3DSA:2.120.10.10 216 299 1.1E-6 T 21-04-2016 IPR011040 Sialidases SPH21_RS21850 ddf145f9f915c24c8f1956d0ce8e880d 489 Gene3D G3DSA:2.120.10.10 129 165 1.1E-6 T 21-04-2016 IPR011040 Sialidases SPH21_RS21850 ddf145f9f915c24c8f1956d0ce8e880d 489 Pfam PF15892 BNR repeat-containing family member 122 363 9.5E-18 T 21-04-2016 SPH21_RS02260 084095c5eed13600728a98a4edea0a18 492 Gene3D G3DSA:1.25.40.10 203 426 1.7E-36 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02260 084095c5eed13600728a98a4edea0a18 492 Pfam PF14322 Starch-binding associating with outer membrane 22 223 1.7E-24 T 21-04-2016 SPH21_RS02260 084095c5eed13600728a98a4edea0a18 492 SUPERFAMILY SSF48452 17 492 1.33E-117 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02260 084095c5eed13600728a98a4edea0a18 492 Pfam PF07980 SusD family 348 492 6.0E-29 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04880 de4bee90e9d0d36933855d334accb9e2 556 SUPERFAMILY SSF55486 254 487 2.32E-38 T 21-04-2016 SPH21_RS04880 de4bee90e9d0d36933855d334accb9e2 556 PANTHER PTHR11533:SF163 47 495 2.7E-42 T 21-04-2016 SPH21_RS04880 de4bee90e9d0d36933855d334accb9e2 556 Gene3D G3DSA:1.10.390.10 354 489 3.9E-15 T 21-04-2016 SPH21_RS04880 de4bee90e9d0d36933855d334accb9e2 556 PANTHER PTHR11533 47 495 2.7E-42 T 21-04-2016 IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase GO:0006508 SPH21_RS04880 de4bee90e9d0d36933855d334accb9e2 556 SUPERFAMILY SSF63737 48 239 1.16E-18 T 21-04-2016 SPH21_RS04880 de4bee90e9d0d36933855d334accb9e2 556 Pfam PF01433 Peptidase family M1 54 383 3.7E-25 T 21-04-2016 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SPH21_RS25265 a27b04f08b7a83cfaa38b82b4e2411f8 194 Gene3D G3DSA:1.20.1250.20 6 103 4.1E-8 T 21-04-2016 SPH21_RS25265 a27b04f08b7a83cfaa38b82b4e2411f8 194 Gene3D G3DSA:1.20.1250.20 155 182 4.1E-8 T 21-04-2016 SPH21_RS25265 a27b04f08b7a83cfaa38b82b4e2411f8 194 SUPERFAMILY SSF103473 6 94 7.85E-9 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS25265 a27b04f08b7a83cfaa38b82b4e2411f8 194 SUPERFAMILY SSF103473 154 181 7.85E-9 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS25265 a27b04f08b7a83cfaa38b82b4e2411f8 194 Pfam PF13858 Protein of unknown function (DUF4199) 13 180 4.5E-26 T 21-04-2016 IPR025250 Protein of unknown function DUF4199 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 PIRSF PIRSF036389 9 736 2.0E-217 T 21-04-2016 IPR012368 Oxidoreductase molybdopterin-binding subunit, IorB-related SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 Gene3D G3DSA:3.30.365.10 65 191 4.3E-31 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 620 686 3.5E-15 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 60 208 1.7E-14 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 335 570 1.8E-34 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 SMART SM01008 225 311 4.8E-15 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 Gene3D G3DSA:3.90.1170.50 194 309 9.8E-16 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 Gene3D G3DSA:3.30.365.10 339 455 8.6E-29 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 SUPERFAMILY SSF56003 21 259 1.81E-37 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 PANTHER PTHR11908:SF2 47 736 3.3E-145 T 21-04-2016 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 Gene3D G3DSA:3.30.365.10 543 735 2.8E-43 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 PANTHER PTHR11908 47 736 3.3E-145 T 21-04-2016 SPH21_RS23450 8fac2fbe46574e93c7e27da43344f125 736 SUPERFAMILY SSF56003 335 733 8.37E-105 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 PANTHER PTHR30173 1 188 7.4E-42 T 21-04-2016 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 Pfam PF08281 Sigma-70, region 4 120 170 2.1E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 17 176 2.0E-19 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 SUPERFAMILY SSF88946 1 98 8.63E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 Gene3D G3DSA:1.10.10.10 118 178 3.9E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 PANTHER PTHR30173:SF20 1 188 7.4E-42 T 21-04-2016 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 16 176 4.9E-38 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 Pfam PF04542 Sigma-70 region 2 22 87 5.3E-5 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 Gene3D G3DSA:1.10.1740.10 1 93 4.7E-15 T 21-04-2016 SPH21_RS24730 1f18da58c898e7f5a6f0653912ae46b3 189 SUPERFAMILY SSF88659 105 179 1.05E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04025 e0e64584ad9ab92ed541a29c40133689 179 PANTHER PTHR35446 5 171 5.8E-25 T 21-04-2016 SPH21_RS04025 e0e64584ad9ab92ed541a29c40133689 179 Gene3D G3DSA:1.20.1290.10 4 87 4.6E-31 T 21-04-2016 IPR029032 AhpD-like SPH21_RS04025 e0e64584ad9ab92ed541a29c40133689 179 Gene3D G3DSA:1.20.1290.10 137 175 4.6E-31 T 21-04-2016 IPR029032 AhpD-like SPH21_RS04025 e0e64584ad9ab92ed541a29c40133689 179 Pfam PF02627 Carboxymuconolactone decarboxylase family 44 96 1.1E-8 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS04025 e0e64584ad9ab92ed541a29c40133689 179 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 57 95 1.0E-10 T 21-04-2016 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS04025 e0e64584ad9ab92ed541a29c40133689 179 PANTHER PTHR35446:SF1 5 171 5.8E-25 T 21-04-2016 SPH21_RS04025 e0e64584ad9ab92ed541a29c40133689 179 SUPERFAMILY SSF69118 5 175 1.44E-40 T 21-04-2016 IPR029032 AhpD-like SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 PANTHER PTHR24221 1 54 7.0E-207 T 21-04-2016 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 PANTHER PTHR24221 85 606 7.0E-207 T 21-04-2016 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 SUPERFAMILY SSF90123 81 350 4.45E-59 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 SUPERFAMILY SSF90123 6 49 4.45E-59 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 Gene3D G3DSA:1.20.1560.10 6 49 2.5E-64 T 21-04-2016 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 Gene3D G3DSA:1.20.1560.10 81 350 2.5E-64 T 21-04-2016 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 Gene3D G3DSA:3.40.50.300 368 596 4.6E-82 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 Pfam PF00005 ABC transporter 383 532 6.7E-32 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 SMART SM00382 392 584 2.3E-13 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 Pfam PF00664 ABC transporter transmembrane region 89 321 1.0E-33 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 ProSitePatterns PS00211 ABC transporters family signature. 504 518 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS07955 87a94d1a31d4ab58e581c6f9d628ef3f 607 SUPERFAMILY SSF52540 357 603 6.57E-93 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 PANTHER PTHR10160 27 396 2.2E-90 T 21-04-2016 SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 SMART SM01003 32 165 1.7E-38 T 21-04-2016 IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 Gene3D G3DSA:3.40.50.1770 30 197 8.4E-46 T 21-04-2016 SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 Pfam PF05222 Alanine dehydrogenase/PNT, N-terminal domain 32 164 5.1E-33 T 21-04-2016 IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 SUPERFAMILY SSF52283 333 389 5.36E-43 T 21-04-2016 SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 SUPERFAMILY SSF52283 30 165 5.36E-43 T 21-04-2016 SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 Gene3D G3DSA:3.40.50.720 198 331 1.4E-26 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 SUPERFAMILY SSF51735 166 331 3.55E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 SMART SM01002 177 325 7.2E-62 T 21-04-2016 IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain SPH21_RS07600 2db1b0bc377ceb3066ba4c6ae4e4c08b 403 Pfam PF01262 Alanine dehydrogenase/PNT, C-terminal domain 170 382 1.0E-61 T 21-04-2016 IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:1.20.120.160 1112 1199 1.2E-14 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:3.40.50.2300 963 1088 8.3E-36 T 21-04-2016 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00091 456 521 2.9 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00091 325 394 0.28 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00091 198 265 310.0 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00091 575 642 8.8E-8 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 575 696 5.5E-22 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 325 451 1.4E-8 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00388 709 774 3.0E-25 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SUPERFAMILY SSF55785 566 687 1.38E-21 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 822 936 7.0E-25 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00387 821 938 2.9E-32 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Pfam PF08447 PAS fold 348 438 1.4E-12 T 21-04-2016 IPR013655 PAS fold-3 GO:0005515 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:1.10.287.130 714 770 3.1E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Pfam PF13426 PAS domain 588 688 1.3E-9 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Pfam PF13426 PAS domain 466 559 0.67 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SUPERFAMILY SSF55785 442 548 1.66E-8 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SUPERFAMILY SSF52172 963 1084 2.13E-31 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 PRINTS PR00344 Bacterial sensor protein C-terminal signature 881 891 1.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 PRINTS PR00344 Bacterial sensor protein C-terminal signature 922 935 1.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 PRINTS PR00344 Bacterial sensor protein C-terminal signature 863 877 1.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 PRINTS PR00344 Bacterial sensor protein C-terminal signature 898 916 1.1E-12 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Pfam PF00512 His Kinase A (phospho-acceptor) domain 709 774 5.0E-21 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:3.30.450.20 576 713 3.0E-24 T 21-04-2016 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Pfam PF01627 Hpt domain 1114 1188 1.9E-7 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:3.30.450.20 452 559 3.2E-10 T 21-04-2016 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SUPERFAMILY SSF55874 763 934 2.1E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SUPERFAMILY SSF47226 1061 1195 3.14E-11 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 PANTHER PTHR24423 573 1122 1.5E-175 T 21-04-2016 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 PANTHER PTHR24423 298 459 1.5E-175 T 21-04-2016 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:3.30.565.10 775 938 4.6E-43 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SUPERFAMILY SSF47384 694 775 1.86E-23 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00086 648 689 0.0024 T 21-04-2016 IPR001610 PAC motif SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00086 401 444 8.0 T 21-04-2016 IPR001610 PAC motif SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SUPERFAMILY SSF55785 331 446 4.54E-16 T 21-04-2016 IPR000014 PAS domain SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:3.30.450.20 309 451 9.1E-25 T 21-04-2016 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Gene3D G3DSA:3.30.450.20 192 308 1.9E-4 T 21-04-2016 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 Pfam PF00072 Response regulator receiver domain 965 1078 8.2E-23 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS26010 a50fec649f9aaceddf8a8ad79e5aad61 1203 SMART SM00448 963 1078 1.1E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS04240 49c7d9a59d2b694c2835205356bf7bfc 421 SUPERFAMILY SSF75011 204 302 6.67E-5 T 21-04-2016 SPH21_RS04240 49c7d9a59d2b694c2835205356bf7bfc 421 SUPERFAMILY SSF75011 73 167 6.67E-5 T 21-04-2016 SPH21_RS04240 49c7d9a59d2b694c2835205356bf7bfc 421 Pfam PF17170 6-bladed beta-propeller 54 350 7.7E-20 T 21-04-2016 SPH21_RS04240 49c7d9a59d2b694c2835205356bf7bfc 421 Gene3D G3DSA:2.120.10.30 209 288 5.9E-9 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS04240 49c7d9a59d2b694c2835205356bf7bfc 421 Gene3D G3DSA:2.120.10.30 67 167 5.9E-9 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS00625 795879c1f758675de7418feee5e533af 327 SUPERFAMILY SSF51430 1 313 3.14E-103 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS00625 795879c1f758675de7418feee5e533af 327 PANTHER PTHR11732:SF269 1 317 3.5E-183 T 21-04-2016 SPH21_RS00625 795879c1f758675de7418feee5e533af 327 Pfam PF00248 Aldo/keto reductase family 16 306 1.0E-76 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS00625 795879c1f758675de7418feee5e533af 327 PANTHER PTHR11732 1 317 3.5E-183 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS00625 795879c1f758675de7418feee5e533af 327 Gene3D G3DSA:3.20.20.100 1 319 1.4E-113 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 TIGRFAM TIGR02632 RhaD_aldol-ADH: rhamnulose-1-phosphate aldolase/alcohol dehydrogenase 32 708 1.5E-284 T 21-04-2016 IPR013454 Bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase KEGG: 00231+1.-.-.-|KEGG: 00592+1.-.-.-|KEGG: 00633+1.-.-.-|KEGG: 00780+1.-.-.-|KEGG: 00860+1.-.-.-|KEGG: 00950+1.-.-.-|KEGG: 00981+1.-.-.- SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 598 617 8.1E-5 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 578 586 8.1E-5 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 524 535 8.1E-5 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PANTHER PTHR24322:SF513 451 582 3.8E-38 T 21-04-2016 SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PANTHER PTHR24322:SF513 598 629 3.8E-38 T 21-04-2016 SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 453 702 4.6E-42 T 21-04-2016 SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 SUPERFAMILY SSF51735 435 705 1.59E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 SMART SM01007 32 234 5.6E-35 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PANTHER PTHR24322 451 582 3.8E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PANTHER PTHR24322 598 629 3.8E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 Gene3D G3DSA:3.40.50.720 424 704 6.3E-61 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 33 233 1.2E-22 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 Gene3D G3DSA:3.40.225.10 33 235 5.0E-36 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 SUPERFAMILY SSF53639 33 235 3.73E-31 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 619 636 2.1E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 524 535 2.1E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 572 588 2.1E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 448 465 2.1E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02545 888c41ebe4afdeaaa78a71b0d3d615e1 708 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 598 617 2.1E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS14625 06db83755882a42c8eae96e1c717fd6e 340 PANTHER PTHR30273:SF2 1 339 5.4E-30 T 21-04-2016 SPH21_RS14625 06db83755882a42c8eae96e1c717fd6e 340 Pfam PF16344 Domain of unknown function (DUF4974) 237 337 2.7E-8 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS14625 06db83755882a42c8eae96e1c717fd6e 340 PANTHER PTHR30273 1 339 5.4E-30 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS14625 06db83755882a42c8eae96e1c717fd6e 340 Pfam PF04773 FecR protein 127 215 1.5E-11 T 21-04-2016 IPR006860 FecR protein SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 Pfam PF02075 Crossover junction endodeoxyribonuclease RuvC 11 159 3.1E-47 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 91 107 4.4E-28 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 115 134 4.4E-28 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 147 159 4.4E-28 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 12 25 4.4E-28 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 69 85 4.4E-28 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 Hamap MF_00034 Crossover junction endodeoxyribonuclease RuvC [ruvC]. 9 162 39.17 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 Gene3D G3DSA:3.30.420.10 10 163 7.6E-55 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 TIGRFAM TIGR00228 ruvC: crossover junction endodeoxyribonuclease RuvC 11 161 3.7E-47 T 21-04-2016 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 SUPERFAMILY SSF53098 10 163 8.35E-42 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 PANTHER PTHR30194 3 179 3.6E-58 T 21-04-2016 SPH21_RS07785 df21992c60efc08149f49a4b36a71a60 188 ProSitePatterns PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 121 156 - T 21-04-2016 IPR020563 Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site GO:0008821 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 Gene3D G3DSA:1.20.1250.20 241 431 9.3E-21 T 21-04-2016 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 Gene3D G3DSA:1.20.1250.20 9 198 4.3E-32 T 21-04-2016 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 Pfam PF00083 Sugar (and other) transporter 9 436 1.7E-113 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 ProSitePatterns PS00216 Sugar transport proteins signature 1. 62 79 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 ProSitePatterns PS00216 Sugar transport proteins signature 1. 294 311 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 SUPERFAMILY SSF103473 3 433 6.28E-80 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 5 432 7.6E-107 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 PRINTS PR00171 Sugar transporter signature 250 260 1.1E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 PRINTS PR00171 Sugar transporter signature 16 26 1.1E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 PRINTS PR00171 Sugar transporter signature 337 358 1.1E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 PRINTS PR00171 Sugar transporter signature 360 372 1.1E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 PRINTS PR00171 Sugar transporter signature 99 118 1.1E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 ProSitePatterns PS00217 Sugar transport proteins signature 2. 104 129 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS21025 3f8e1e200cbcb52c156d4a720f2f1972 451 PANTHER PTHR23500 4 439 2.5E-153 T 21-04-2016 SPH21_RS12440 c2a5254e43f801fe4b806280394c82ef 60 SUPERFAMILY SSF46626 11 59 5.43E-5 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS12440 c2a5254e43f801fe4b806280394c82ef 60 Gene3D G3DSA:1.10.760.10 10 60 2.6E-8 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS14245 73dce7f994ea999aa311e9daabcade7a 855 PIRSF PIRSF007663 11 824 1.0E-288 T 21-04-2016 IPR016518 Alpha-L-fucosidase GO:0004560 KEGG: 00511+3.2.1.51 SPH21_RS14245 73dce7f994ea999aa311e9daabcade7a 855 PANTHER PTHR31084 17 829 0.0 T 21-04-2016 SPH21_RS14245 73dce7f994ea999aa311e9daabcade7a 855 Gene3D G3DSA:2.70.98.50 31 421 2.2E-144 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS14245 73dce7f994ea999aa311e9daabcade7a 855 SUPERFAMILY SSF48208 291 788 4.2E-92 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS14245 73dce7f994ea999aa311e9daabcade7a 855 PANTHER PTHR31084:SF0 17 829 0.0 T 21-04-2016 SPH21_RS14245 73dce7f994ea999aa311e9daabcade7a 855 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 32 279 4.1E-69 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS01705 642bbcf32926a7ebb133c781ddb7b937 380 PANTHER PTHR30160:SF13 37 362 6.9E-66 T 21-04-2016 SPH21_RS01705 642bbcf32926a7ebb133c781ddb7b937 380 Hamap MF_00409 Tetraacyldisaccharide 4'-kinase [lpxK]. 22 376 26.521 T 21-04-2016 IPR003758 Tetraacyldisaccharide 4'-kinase GO:0005524|GO:0009029|GO:0009245 KEGG: 00030+2.7.1.13|KEGG: 00540+2.7.1.130|UniPathway: UPA00359 SPH21_RS01705 642bbcf32926a7ebb133c781ddb7b937 380 Pfam PF02606 Tetraacyldisaccharide-1-P 4'-kinase 39 361 4.4E-78 T 21-04-2016 IPR003758 Tetraacyldisaccharide 4'-kinase GO:0005524|GO:0009029|GO:0009245 KEGG: 00030+2.7.1.13|KEGG: 00540+2.7.1.130|UniPathway: UPA00359 SPH21_RS01705 642bbcf32926a7ebb133c781ddb7b937 380 PANTHER PTHR30160 37 362 6.9E-66 T 21-04-2016 SPH21_RS01705 642bbcf32926a7ebb133c781ddb7b937 380 TIGRFAM TIGR00682 lpxK: tetraacyldisaccharide 4'-kinase 45 336 2.9E-47 T 21-04-2016 IPR003758 Tetraacyldisaccharide 4'-kinase GO:0005524|GO:0009029|GO:0009245 KEGG: 00030+2.7.1.13|KEGG: 00540+2.7.1.130|UniPathway: UPA00359 SPH21_RS01705 642bbcf32926a7ebb133c781ddb7b937 380 SUPERFAMILY SSF52540 73 175 6.05E-7 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01705 642bbcf32926a7ebb133c781ddb7b937 380 SUPERFAMILY SSF52540 204 223 6.05E-7 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 ProSitePatterns PS01223 Gamma-glutamyl phosphate reductase signature. 321 343 - T 21-04-2016 IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|UniPathway: UPA00098 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 PIRSF PIRSF000151 1 415 3.9E-154 T 21-04-2016 IPR012134 Glutamate-5-semialdehyde dehydrogenase GO:0004350|GO:0006561|GO:0050661|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|UniPathway: UPA00098 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 TIGRFAM TIGR00407 proA: glutamate-5-semialdehyde dehydrogenase 10 404 4.9E-130 T 21-04-2016 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|UniPathway: UPA00098 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 SUPERFAMILY SSF53720 5 414 1.83E-97 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 Gene3D G3DSA:3.40.309.10 220 372 5.4E-29 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 Hamap MF_00412 Gamma-glutamyl phosphate reductase [proA]. 2 414 35.98 T 21-04-2016 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|UniPathway: UPA00098 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 Gene3D G3DSA:3.40.605.10 5 217 1.7E-87 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 Gene3D G3DSA:3.40.605.10 373 414 1.7E-87 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 PANTHER PTHR11063:SF8 8 415 3.9E-151 T 21-04-2016 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 PANTHER PTHR11063 8 415 3.9E-151 T 21-04-2016 SPH21_RS18190 39642ab7f3cf4597f8a6227883ce6bc9 415 Pfam PF00171 Aldehyde dehydrogenase family 8 264 1.1E-6 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 76 270 9.5E-28 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 Pfam PF00529 HlyD membrane-fusion protein of T1SS 16 273 3.7E-6 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 Gene3D G3DSA:2.40.50.100 34 103 8.6E-5 T 21-04-2016 SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 PANTHER PTHR30469:SF15 1 362 6.7E-68 T 21-04-2016 SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 Gene3D G3DSA:2.40.50.100 164 197 8.6E-18 T 21-04-2016 SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 45 351 7.7E-72 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 PANTHER PTHR30469 1 362 6.7E-68 T 21-04-2016 SPH21_RS08395 a279304ec6cca83f8500d51fef815421 363 SUPERFAMILY SSF111369 60 274 1.83E-26 T 21-04-2016 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 PANTHER PTHR30158:SF5 14 372 1.1E-109 T 21-04-2016 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 SUPERFAMILY SSF111369 48 294 1.02E-46 T 21-04-2016 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 Gene3D G3DSA:1.20.1600.10 99 173 2.7E-6 T 21-04-2016 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 Gene3D G3DSA:2.40.50.100 174 200 1.8E-19 T 21-04-2016 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 Gene3D G3DSA:2.40.50.100 60 93 1.8E-19 T 21-04-2016 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 37 371 6.6E-70 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 Pfam PF13533 Biotin-lipoyl like 60 108 8.5E-12 T 21-04-2016 SPH21_RS12875 f1423ccefd6082580e1dce1655521730 381 PANTHER PTHR30158 14 372 1.1E-109 T 21-04-2016 SPH21_RS16220 e2eb8f03fd3e76641a596403402becb4 269 SUPERFAMILY SSF53697 7 245 1.6E-69 T 21-04-2016 SPH21_RS16220 e2eb8f03fd3e76641a596403402becb4 269 Gene3D G3DSA:3.40.50.10490 4 245 1.2E-82 T 21-04-2016 SPH21_RS16220 e2eb8f03fd3e76641a596403402becb4 269 Hamap MF_00068 N-acetylmuramic acid 6-phosphate etherase [murQ]. 1 267 33.844 T 21-04-2016 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126|UniPathway: UPA00342 SPH21_RS16220 e2eb8f03fd3e76641a596403402becb4 269 Pfam PF13580 SIS domain 35 157 1.2E-6 T 21-04-2016 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 Reactome: REACT_17015 SPH21_RS16220 e2eb8f03fd3e76641a596403402becb4 269 TIGRFAM TIGR00274 TIGR00274: N-acetylmuramic acid 6-phosphate etherase 6 260 1.4E-98 T 21-04-2016 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126|UniPathway: UPA00342 SPH21_RS16220 e2eb8f03fd3e76641a596403402becb4 269 ProSitePatterns PS01272 Glucokinase regulatory protein family signature. 181 198 - T 21-04-2016 IPR005486 Glucokinase regulatory protein, conserved site KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126|UniPathway: UPA00342 SPH21_RS16220 e2eb8f03fd3e76641a596403402becb4 269 PANTHER PTHR10088 4 263 8.2E-115 T 21-04-2016 SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 Gene3D G3DSA:2.40.50.40 130 199 7.9E-20 T 21-04-2016 SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 Pfam PF00072 Response regulator receiver domain 6 112 5.4E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 SMART SM00850 140 232 1.0E-21 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 Gene3D G3DSA:3.40.50.2300 1 125 1.7E-23 T 21-04-2016 SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 PANTHER PTHR26402 2 117 1.1E-19 T 21-04-2016 SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 SMART SM00448 2 112 9.5E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 SUPERFAMILY SSF52172 1 125 8.68E-23 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS04745 aa803f3abf35d07187397f150511c8dd 242 Pfam PF04397 LytTr DNA-binding domain 141 230 4.3E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 SUPERFAMILY SSF55347 139 269 3.43E-16 T 21-04-2016 SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 SUPERFAMILY SSF51735 3 152 6.0E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 4 123 1.4E-26 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 Gene3D G3DSA:3.30.360.10 301 355 1.9E-25 T 21-04-2016 SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 Gene3D G3DSA:3.30.360.10 141 255 1.9E-25 T 21-04-2016 SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 PANTHER PTHR22604 1 356 2.1E-61 T 21-04-2016 SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 PANTHER PTHR22604:SF122 1 356 2.1E-61 T 21-04-2016 SPH21_RS10100 2661e01963f03484075676f55104f1a4 356 Gene3D G3DSA:3.40.50.720 1 140 9.8E-36 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18625 6232c932f59de5e366f7289091706ee1 393 PANTHER PTHR30388:SF4 177 383 8.9E-85 T 21-04-2016 SPH21_RS18625 6232c932f59de5e366f7289091706ee1 393 PANTHER PTHR30388:SF4 5 129 8.9E-85 T 21-04-2016 SPH21_RS18625 6232c932f59de5e366f7289091706ee1 393 PANTHER PTHR30388 177 383 8.9E-85 T 21-04-2016 SPH21_RS18625 6232c932f59de5e366f7289091706ee1 393 PANTHER PTHR30388 5 129 8.9E-85 T 21-04-2016 SPH21_RS18625 6232c932f59de5e366f7289091706ee1 393 Pfam PF02625 XdhC and CoxI family 15 81 1.2E-22 T 21-04-2016 IPR003777 XdhC- CoxI SPH21_RS18625 6232c932f59de5e366f7289091706ee1 393 Pfam PF13478 XdhC Rossmann domain 213 357 1.7E-36 T 21-04-2016 IPR027051 XdhC Rossmann domain SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Gene3D G3DSA:3.40.50.1010 2 186 3.6E-61 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SUPERFAMILY SSF53098 338 515 2.56E-43 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Gene3D G3DSA:1.10.150.20 712 818 1.1E-32 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PANTHER PTHR10133:SF27 321 927 0.0 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PANTHER PTHR10133:SF27 2 282 0.0 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 TIGRFAM TIGR00593 pola: DNA polymerase I 3 928 1.3E-293 T 21-04-2016 IPR018320 DNA polymerase 1 GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SMART SM00475 1 262 6.8E-110 T 21-04-2016 IPR002421 5'-3' exonuclease, N-terminal GO:0003677 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Pfam PF01612 3'-5' exonuclease 335 515 1.1E-32 T 21-04-2016 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Pfam PF00476 DNA polymerase family A 549 925 3.5E-153 T 21-04-2016 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Gene3D G3DSA:1.10.150.20 187 246 7.0E-27 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SMART SM00482 685 892 7.9E-109 T 21-04-2016 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SUPERFAMILY SSF47807 174 284 3.74E-30 T 21-04-2016 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Gene3D G3DSA:1.20.1060.10 542 661 2.4E-36 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SMART SM00279 174 209 3.9E-12 T 21-04-2016 IPR008918 Helix-hairpin-helix motif, class 2 GO:0003677|GO:0003824 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 845 861 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 730 743 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 791 802 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 813 824 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 654 676 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 677 692 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 700 723 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 754 779 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PRINTS PR00868 DNA-polymerase family A (pol I) signature 875 888 1.4E-76 T 21-04-2016 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Gene3D G3DSA:3.30.70.370 819 928 4.3E-64 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Gene3D G3DSA:3.30.70.370 662 711 4.3E-64 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SUPERFAMILY SSF56672 522 928 3.78E-150 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold 175 266 1.1E-28 T 21-04-2016 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SUPERFAMILY SSF88723 2 150 1.11E-47 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 ProSitePatterns PS00447 DNA polymerase family A signature. 754 773 - T 21-04-2016 IPR019760 DNA-directed DNA polymerase, family A, conserved site GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Gene3D G3DSA:3.30.420.10 332 540 3.4E-66 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 SMART SM00474 335 516 3.1E-29 T 21-04-2016 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PANTHER PTHR10133 321 927 0.0 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 PANTHER PTHR10133 2 282 0.0 T 21-04-2016 SPH21_RS07495 9948f17a2525d377d172195f680f2480 928 Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain 2 169 2.4E-49 T 21-04-2016 IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal GO:0003677 SPH21_RS21920 1ccd088d42c14c2f5096588b0a03cba5 248 Pfam PF06414 Zeta toxin 105 195 2.3E-5 T 21-04-2016 IPR010488 Zeta toxin domain GO:0005524|GO:0016301 SPH21_RS21920 1ccd088d42c14c2f5096588b0a03cba5 248 PANTHER PTHR39206 87 243 1.0E-22 T 21-04-2016 SPH21_RS21920 1ccd088d42c14c2f5096588b0a03cba5 248 PANTHER PTHR39206:SF1 87 243 1.0E-22 T 21-04-2016 SPH21_RS21920 1ccd088d42c14c2f5096588b0a03cba5 248 Gene3D G3DSA:3.40.50.300 139 214 8.5E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21920 1ccd088d42c14c2f5096588b0a03cba5 248 Gene3D G3DSA:3.40.50.300 5 107 8.5E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21920 1ccd088d42c14c2f5096588b0a03cba5 248 SUPERFAMILY SSF52540 108 195 2.21E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21920 1ccd088d42c14c2f5096588b0a03cba5 248 SUPERFAMILY SSF52540 7 41 2.21E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03600 65150c62261851caef343c69758dffa8 450 Pfam PF01120 Alpha-L-fucosidase 28 353 1.5E-87 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 PANTHER PTHR10030 33 52 5.4E-70 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 PANTHER PTHR10030 73 398 5.4E-70 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 PRINTS PR00741 Glycosyl hydrolase family 29 signature 206 222 9.3E-21 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 PRINTS PR00741 Glycosyl hydrolase family 29 signature 306 327 9.3E-21 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 PRINTS PR00741 Glycosyl hydrolase family 29 signature 339 361 9.3E-21 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 PRINTS PR00741 Glycosyl hydrolase family 29 signature 115 131 9.3E-21 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 PIRSF PIRSF001092 16 447 2.3E-109 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 SMART SM00812 23 401 7.5E-97 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03600 65150c62261851caef343c69758dffa8 450 SUPERFAMILY SSF51445 23 356 3.42E-96 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS03600 65150c62261851caef343c69758dffa8 450 Gene3D G3DSA:3.20.20.80 21 356 1.4E-101 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS07465 52c778d8e57dea2b5bed8d8bb60eef2d 191 SUPERFAMILY SSF52374 1 191 3.26E-54 T 21-04-2016 SPH21_RS07465 52c778d8e57dea2b5bed8d8bb60eef2d 191 Pfam PF01467 Cytidylyltransferase-like 6 164 2.8E-25 T 21-04-2016 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SPH21_RS07465 52c778d8e57dea2b5bed8d8bb60eef2d 191 Hamap MF_00244 Probable nicotinate-nucleotide adenylyltransferase [nadD]. 2 191 28.091 T 21-04-2016 IPR005248 Probable nicotinate-nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: REACT_11193|UniPathway: UPA00253 SPH21_RS07465 52c778d8e57dea2b5bed8d8bb60eef2d 191 TIGRFAM TIGR00482 TIGR00482: nicotinate (nicotinamide) nucleotide adenylyltransferase 6 190 7.2E-53 T 21-04-2016 IPR005248 Probable nicotinate-nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: REACT_11193|UniPathway: UPA00253 SPH21_RS07465 52c778d8e57dea2b5bed8d8bb60eef2d 191 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 4 66 1.2E-7 T 21-04-2016 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SPH21_RS07465 52c778d8e57dea2b5bed8d8bb60eef2d 191 Gene3D G3DSA:3.40.50.620 1 190 6.2E-61 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS07465 52c778d8e57dea2b5bed8d8bb60eef2d 191 PANTHER PTHR12039 3 191 4.1E-51 T 21-04-2016 IPR005248 Probable nicotinate-nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: REACT_11193|UniPathway: UPA00253 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 SUPERFAMILY SSF54211 4 125 5.08E-39 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS07625 102a220ec746a90c411930105aed201f 470 Gene3D G3DSA:3.30.1700.10 129 303 5.3E-51 T 21-04-2016 IPR011334 UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108|KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00359 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 Pfam PF03331 UDP-3-O-acyl N-acetylglycosamine deacetylase 5 299 4.3E-95 T 21-04-2016 IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108|KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00359 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 PANTHER PTHR30272 252 464 1.3E-91 T 21-04-2016 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 TIGRFAM TIGR00325 lpxC: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 3 225 4.0E-63 T 21-04-2016 IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108|KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00359 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 PANTHER PTHR30272:SF1 252 464 1.3E-91 T 21-04-2016 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 Hamap MF_00388 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [lpxC]. 3 304 36.493 T 21-04-2016 IPR004463 UDP-3-O-acyl N-acetylglucosamine deacetylase GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108|KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00359 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 Gene3D G3DSA:3.30.230.20 4 126 5.6E-45 T 21-04-2016 IPR015870 UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal GO:0008759|GO:0009245 KEGG: 00540+3.5.1.108|KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497|UniPathway: UPA00359 SPH21_RS07625 102a220ec746a90c411930105aed201f 470 Gene3D G3DSA:3.10.129.10 317 461 1.6E-48 T 21-04-2016 IPR029069 HotDog domain SPH21_RS07625 102a220ec746a90c411930105aed201f 470 SUPERFAMILY SSF54211 143 300 1.29E-39 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS07625 102a220ec746a90c411930105aed201f 470 SUPERFAMILY SSF54637 325 461 1.64E-37 T 21-04-2016 IPR029069 HotDog domain SPH21_RS07625 102a220ec746a90c411930105aed201f 470 Pfam PF07977 FabA-like domain 331 455 9.4E-26 T 21-04-2016 IPR013114 Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 Hamap MF_01820 Putative ribosome biogenesis GTPase RsgA [rsgA]. 26 324 29.992 T 21-04-2016 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 PANTHER PTHR32120 2 350 3.3E-132 T 21-04-2016 SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 TIGRFAM TIGR00157 TIGR00157: ribosome small subunit-dependent GTPase A 67 316 4.4E-46 T 21-04-2016 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 Gene3D G3DSA:3.40.50.300 103 260 4.3E-34 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 Gene3D G3DSA:2.40.50.140 27 88 6.1E-6 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 SUPERFAMILY SSF50249 27 90 5.4E-8 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 Pfam PF03193 Protein of unknown function, DUF258 86 260 2.2E-42 T 21-04-2016 IPR010914 RsgA type GTPase domain GO:0003924|GO:0005525 SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 PANTHER PTHR32120:SF8 2 350 3.3E-132 T 21-04-2016 SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 Gene3D G3DSA:1.10.40.50 271 320 1.3E-16 T 21-04-2016 SPH21_RS15960 d20af3bef0a1bba1fb45fad267c33b11 350 SUPERFAMILY SSF52540 104 320 2.39E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18595 5be2a4a2349071bf18907d34d0fab083 365 PANTHER PTHR10953 2 333 5.9E-83 T 21-04-2016 SPH21_RS18595 5be2a4a2349071bf18907d34d0fab083 365 Pfam PF00581 Rhodanese-like domain 276 360 3.3E-5 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS18595 5be2a4a2349071bf18907d34d0fab083 365 Pfam PF00899 ThiF family 9 232 1.5E-58 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS18595 5be2a4a2349071bf18907d34d0fab083 365 Gene3D G3DSA:3.40.50.720 3 236 1.1E-69 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18595 5be2a4a2349071bf18907d34d0fab083 365 PANTHER PTHR10953:SF153 2 333 5.9E-83 T 21-04-2016 SPH21_RS18595 5be2a4a2349071bf18907d34d0fab083 365 Gene3D G3DSA:3.40.250.10 269 360 6.2E-12 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS18595 5be2a4a2349071bf18907d34d0fab083 365 SUPERFAMILY SSF69572 6 336 3.53E-81 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 Gene3D G3DSA:3.40.250.10 266 349 8.7E-6 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 Pfam PF00753 Metallo-beta-lactamase superfamily 15 190 5.5E-9 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 SUPERFAMILY SSF52821 242 346 2.36E-9 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 SUPERFAMILY SSF52821 360 463 9.82E-30 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 Gene3D G3DSA:3.60.15.10 5 251 2.1E-58 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 SMART SM00450 365 460 7.2E-26 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 PANTHER PTHR11935:SF9 1 303 1.5E-93 T 21-04-2016 SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 Pfam PF00581 Rhodanese-like domain 367 456 4.3E-17 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 SUPERFAMILY SSF56281 13 251 1.82E-50 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 PANTHER PTHR11935 1 303 1.5E-93 T 21-04-2016 SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 SMART SM00849 12 191 3.3E-25 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17860 0fe11efe466b1bcb5de9735617c61cb0 469 Gene3D G3DSA:3.40.250.10 361 467 1.5E-29 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS13495 f8d760d5583164e2ab6102d0ba72b7a7 1107 Pfam PF01578 Cytochrome C assembly protein 847 1053 1.3E-41 T 21-04-2016 IPR002541 Cytochrome c assembly protein GO:0017004|GO:0020037 SPH21_RS13495 f8d760d5583164e2ab6102d0ba72b7a7 1107 TIGRFAM TIGR03144 cytochr_II_ccsB: cytochrome c-type biogenesis protein CcsB 824 1056 2.0E-56 T 21-04-2016 IPR017562 Cytochrome c-type biogenesis protein CcsA GO:0017004 SPH21_RS13495 f8d760d5583164e2ab6102d0ba72b7a7 1107 PANTHER PTHR30071:SF5 765 1090 2.0E-66 T 21-04-2016 SPH21_RS13495 f8d760d5583164e2ab6102d0ba72b7a7 1107 PANTHER PTHR30071 765 1090 2.0E-66 T 21-04-2016 SPH21_RS13495 f8d760d5583164e2ab6102d0ba72b7a7 1107 Pfam PF05140 ResB-like family 75 119 6.9E-7 T 21-04-2016 IPR007816 ResB-like domain SPH21_RS13495 f8d760d5583164e2ab6102d0ba72b7a7 1107 Pfam PF05140 ResB-like family 347 533 3.9E-11 T 21-04-2016 IPR007816 ResB-like domain SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 PANTHER PTHR23406:SF23 372 442 8.7E-174 T 21-04-2016 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 PANTHER PTHR23406:SF23 31 355 8.7E-174 T 21-04-2016 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 SMART SM01274 19 152 1.3E-82 T 21-04-2016 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 Gene3D G3DSA:3.40.50.10750 566 724 3.7E-53 T 21-04-2016 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 SUPERFAMILY SSF53659 429 751 4.52E-90 T 21-04-2016 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 Pfam PF01515 Phosphate acetyl/butaryl transferase 429 748 1.5E-95 T 21-04-2016 IPR002505 Phosphate acetyl/butaryl transferase GO:0008152|GO:0016746 KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637|UniPathway: UPA00340 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 Pfam PF00390 Malic enzyme, N-terminal domain 21 152 4.0E-28 T 21-04-2016 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 SUPERFAMILY SSF53223 10 162 4.46E-54 T 21-04-2016 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 PANTHER PTHR23406 372 442 8.7E-174 T 21-04-2016 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 PANTHER PTHR23406 31 355 8.7E-174 T 21-04-2016 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 PIRSF PIRSF036684 1 756 0.0 T 21-04-2016 IPR012188 Malic enzyme, phosphate acetyl/butaryl transferase GO:0004473|GO:0005829|GO:0006108|GO:0016616|GO:0030145|GO:0046872|GO:0055114 KEGG: 00620+1.1.1.40|KEGG: 00710+1.1.1.40|MetaCyc: PWY-241|MetaCyc: PWY-7117 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 SMART SM00919 164 400 6.1E-136 T 21-04-2016 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 Gene3D G3DSA:3.40.50.720 162 448 1.6E-85 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 Pfam PF03949 Malic enzyme, NAD binding domain 166 369 1.6E-22 T 21-04-2016 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 SUPERFAMILY SSF51735 164 442 1.27E-84 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10290 8b7eb6f6ecd01a76c9c5dd6ca5942762 765 Gene3D G3DSA:3.40.50.10380 6 161 4.0E-51 T 21-04-2016 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 SUPERFAMILY SSF54106 422 467 4.05E-10 T 21-04-2016 IPR018392 LysM domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 Pfam PF01464 Transglycosylase SLT domain 123 220 1.3E-24 T 21-04-2016 IPR008258 Transglycosylase SLT domain 1 SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 SUPERFAMILY SSF54106 359 402 1.18E-10 T 21-04-2016 IPR018392 LysM domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 SUPERFAMILY SSF53955 91 250 1.88E-35 T 21-04-2016 IPR023346 Lysozyme-like domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 Gene3D G3DSA:3.10.350.10 421 467 2.1E-17 T 21-04-2016 IPR018392 LysM domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 Gene3D G3DSA:3.10.350.10 357 403 2.4E-17 T 21-04-2016 IPR018392 LysM domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 PANTHER PTHR21666 82 467 5.7E-61 T 21-04-2016 SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 Pfam PF01476 LysM domain 425 467 2.9E-12 T 21-04-2016 IPR018392 LysM domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 Pfam PF01476 LysM domain 361 403 1.5E-11 T 21-04-2016 IPR018392 LysM domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 PANTHER PTHR21666:SF206 82 467 5.7E-61 T 21-04-2016 SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 Gene3D G3DSA:1.10.530.10 107 254 1.1E-40 T 21-04-2016 SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 SMART SM00257 360 403 1.2E-13 T 21-04-2016 IPR018392 LysM domain SPH21_RS05630 83816626f78b8ac97008920b043eab55 470 SMART SM00257 424 468 6.3E-13 T 21-04-2016 IPR018392 LysM domain SPH21_RS05985 6b50ecb0ccb06019b9fc41969608074d 72 SUPERFAMILY SSF47413 3 58 1.09E-6 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS05985 6b50ecb0ccb06019b9fc41969608074d 72 Gene3D G3DSA:1.10.260.40 4 60 1.0E-5 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS05985 6b50ecb0ccb06019b9fc41969608074d 72 Pfam PF13443 Cro/C1-type HTH DNA-binding domain 5 61 3.3E-7 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 Pfam PF13623 SurA N-terminal domain 4 150 7.3E-39 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 Gene3D G3DSA:3.10.50.40 574 678 4.9E-7 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 Gene3D G3DSA:3.10.50.40 256 345 2.2E-4 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 Gene3D G3DSA:3.10.50.40 346 448 6.1E-28 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 Gene3D G3DSA:3.10.50.40 460 572 3.5E-8 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 SUPERFAMILY SSF54534 346 444 3.46E-22 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 Pfam PF13616 PPIC-type PPIASE domain 334 445 1.9E-26 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 PANTHER PTHR10657 3 181 4.9E-23 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 PANTHER PTHR10657 328 601 4.9E-23 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 SUPERFAMILY SSF54534 574 657 5.61E-6 T 21-04-2016 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 Pfam PF13145 PPIC-type PPIASE domain 480 562 1.2E-8 T 21-04-2016 IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type GO:0016853 SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 SUPERFAMILY SSF109998 47 186 9.02E-13 T 21-04-2016 IPR027304 Trigger factor/SurA domain SPH21_RS06940 0383bd185b0e4da223ff6142842f2b16 701 SUPERFAMILY SSF109998 221 269 9.02E-13 T 21-04-2016 IPR027304 Trigger factor/SurA domain SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 SMART SM00448 7 115 1.3E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 Gene3D G3DSA:3.40.50.2300 4 122 1.1E-25 T 21-04-2016 SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 PANTHER PTHR26402 7 115 6.6E-26 T 21-04-2016 SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 SMART SM00850 146 237 2.2E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 Gene3D G3DSA:2.40.50.40 139 205 2.2E-20 T 21-04-2016 SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 SUPERFAMILY SSF52172 5 122 1.85E-26 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 Pfam PF00072 Response regulator receiver domain 11 115 6.3E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20075 c348fa99d2d710d9e2afb087ae221fe0 243 Pfam PF04397 LytTr DNA-binding domain 147 236 7.1E-19 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 ProSitePatterns PS01296 RsmI AdoMet-dependent methyltransferase protein family signature. 79 90 - T 21-04-2016 IPR018063 SAM-dependent methyltransferase RsmI, conserved site GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 Gene3D G3DSA:3.30.950.10 110 220 6.1E-39 T 21-04-2016 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 1 200 1.1E-26 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 PANTHER PTHR21091 1 219 9.0E-87 T 21-04-2016 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 PANTHER PTHR21091:SF18 1 219 9.0E-87 T 21-04-2016 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 TIGRFAM TIGR00096 TIGR00096: 16S rRNA (cytidine(1402)-2'-O)-methyltransferase 1 219 1.4E-73 T 21-04-2016 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 SUPERFAMILY SSF53790 1 217 1.44E-79 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 Gene3D G3DSA:3.40.1010.10 1 109 3.2E-18 T 21-04-2016 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 PIRSF PIRSF005917 1 221 2.8E-91 T 21-04-2016 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS25700 3f766693b0ebbb41a9fa570bb97f79eb 221 Hamap MF_01877 Ribosomal RNA small subunit methyltransferase I [rsmI]. 1 219 37.151 T 21-04-2016 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 Gene3D G3DSA:3.20.20.120 163 399 8.7E-83 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 PANTHER PTHR13794:SF4 214 421 1.0E-104 T 21-04-2016 SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 PANTHER PTHR13794:SF4 63 197 1.0E-104 T 21-04-2016 SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 SUPERFAMILY SSF51604 142 420 6.03E-77 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 Gene3D G3DSA:3.30.390.10 42 162 1.5E-35 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 63 154 7.4E-12 T 21-04-2016 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 SUPERFAMILY SSF54826 55 154 3.05E-23 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 Pfam PF13378 Enolase C-terminal domain-like 183 412 9.1E-57 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 PANTHER PTHR13794 214 421 1.0E-104 T 21-04-2016 IPR001354 Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase GO:0003824|GO:0008152 SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 PANTHER PTHR13794 63 197 1.0E-104 T 21-04-2016 IPR001354 Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase GO:0003824|GO:0008152 SPH21_RS13090 811e8a68282b8e0f4ccb8b984c3e08a4 426 SMART SM00922 177 290 4.9E-23 T 21-04-2016 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SPH21_RS23895 426468bfc7d3dabcd4e76cd89fec9f7f 318 Pfam PF00801 PKD domain 63 109 2.0E-6 T 21-04-2016 IPR000601 PKD domain SPH21_RS23895 426468bfc7d3dabcd4e76cd89fec9f7f 318 SUPERFAMILY SSF49299 50 112 1.22E-11 T 21-04-2016 IPR000601 PKD domain SPH21_RS23895 426468bfc7d3dabcd4e76cd89fec9f7f 318 Gene3D G3DSA:2.60.40.670 133 187 1.4E-4 T 21-04-2016 IPR000601 PKD domain SPH21_RS23895 426468bfc7d3dabcd4e76cd89fec9f7f 318 Gene3D G3DSA:2.60.40.670 49 111 3.6E-14 T 21-04-2016 IPR000601 PKD domain SPH21_RS23895 426468bfc7d3dabcd4e76cd89fec9f7f 318 SMART SM00089 47 121 4.1E-5 T 21-04-2016 IPR022409 PKD/Chitinase domain SPH21_RS22605 bfbca7ef9969acd221386b449284d4fb 245 Pfam PF01940 Integral membrane protein DUF92 24 237 2.5E-42 T 21-04-2016 IPR002794 Protein of unknown function DUF92, TMEM19 GO:0016021 SPH21_RS22605 bfbca7ef9969acd221386b449284d4fb 245 PANTHER PTHR13353 18 244 8.1E-32 T 21-04-2016 IPR002794 Protein of unknown function DUF92, TMEM19 GO:0016021 SPH21_RS25050 2e29073334f7ac4e2a72e4acc091d3fb 122 Pfam PF01061 ABC-2 type transporter 6 84 1.5E-13 T 21-04-2016 IPR013525 ABC-2 type transporter GO:0016020 SPH21_RS25050 2e29073334f7ac4e2a72e4acc091d3fb 122 PANTHER PTHR30294 2 121 5.1E-32 T 21-04-2016 SPH21_RS25050 2e29073334f7ac4e2a72e4acc091d3fb 122 PANTHER PTHR30294:SF24 2 121 5.1E-32 T 21-04-2016 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 SMART SM00028 167 200 1.8 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 SMART SM00028 83 116 18.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 SMART SM00028 293 326 390.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 SUPERFAMILY SSF48452 150 379 1.76E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 PANTHER PTHR24421 402 663 5.6E-39 T 21-04-2016 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 PRINTS PR00344 Bacterial sensor protein C-terminal signature 652 665 9.0E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 PRINTS PR00344 Bacterial sensor protein C-terminal signature 611 625 9.0E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 PRINTS PR00344 Bacterial sensor protein C-terminal signature 628 646 9.0E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 Gene3D G3DSA:3.30.565.10 522 667 2.8E-18 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 SUPERFAMILY SSF55874 547 664 7.6E-24 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 579 664 1.2E-11 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 PANTHER PTHR24421:SF10 402 663 5.6E-39 T 21-04-2016 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 Gene3D G3DSA:1.25.40.10 157 389 1.5E-11 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 Pfam PF07730 Histidine kinase 473 537 1.1E-8 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 SMART SM00387 575 668 4.0E-13 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03550 8b261bb6e6c1a0c5a9ba8e57d31a4703 675 Gene3D G3DSA:1.25.40.10 66 156 2.1E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10770 d181c5233dbe5b2d0caae0b5343427a2 281 SUPERFAMILY SSF47240 1 269 4.96E-82 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS10770 d181c5233dbe5b2d0caae0b5343427a2 281 Gene3D G3DSA:3.30.1530.10 207 263 5.0E-8 T 21-04-2016 IPR027407 Manganese catalase, domain 2 SPH21_RS10770 d181c5233dbe5b2d0caae0b5343427a2 281 PANTHER PTHR30565 2 225 7.2E-102 T 21-04-2016 SPH21_RS10770 d181c5233dbe5b2d0caae0b5343427a2 281 PANTHER PTHR30565:SF2 2 225 7.2E-102 T 21-04-2016 SPH21_RS10770 d181c5233dbe5b2d0caae0b5343427a2 281 Gene3D G3DSA:1.20.1260.10 1 196 1.6E-74 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS10770 d181c5233dbe5b2d0caae0b5343427a2 281 Pfam PF05067 Manganese containing catalase 1 260 1.1E-78 T 21-04-2016 IPR007760 Manganese catalase SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 Gene3D G3DSA:3.40.50.300 592 732 2.8E-29 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 Gene3D G3DSA:3.40.50.300 503 527 2.8E-29 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 Pfam PF00270 DEAD/DEAH box helicase 296 458 1.2E-12 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 SMART SM00490 595 688 1.7E-5 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 PANTHER PTHR30580 8 128 6.8E-230 T 21-04-2016 SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 PANTHER PTHR30580 145 829 6.8E-230 T 21-04-2016 SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 SUPERFAMILY SSF52540 290 473 1.93E-36 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 Hamap MF_00983 Probable primosomal protein N' [priA]. 20 829 23.44 T 21-04-2016 IPR005259 Primosomal protein N' GO:0003677|GO:0004003|GO:0006260|GO:0032508 SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 TIGRFAM TIGR00595 priA: primosomal protein N' 315 829 8.7E-179 T 21-04-2016 IPR005259 Primosomal protein N' GO:0003677|GO:0004003|GO:0006260|GO:0032508 SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 SMART SM00487 289 487 1.3E-20 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 Pfam PF00271 Helicase conserved C-terminal domain 605 687 1.7E-7 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 Gene3D G3DSA:3.40.50.300 286 477 1.2E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01575 c9347b7be416522cf2c7b64b5d5ec3aa 829 SUPERFAMILY SSF52540 559 733 4.09E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 PANTHER PTHR33546 258 898 9.1E-28 T 21-04-2016 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 Pfam PF00034 Cytochrome c 750 883 1.3E-8 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 PANTHER PTHR33546:SF1 258 898 9.1E-28 T 21-04-2016 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 Gene3D G3DSA:1.10.760.10 740 824 1.7E-14 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 Gene3D G3DSA:1.10.760.10 859 883 1.7E-14 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 TIGRFAM TIGR02603 CxxCH_TIGR02603: putative heme-binding domain 748 883 1.2E-28 T 21-04-2016 IPR013427 Haem-binding domain, putative SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 Gene3D G3DSA:2.120.10.30 39 417 3.1E-35 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 SUPERFAMILY SSF46626 859 883 1.17E-14 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 SUPERFAMILY SSF46626 746 803 1.17E-14 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 SUPERFAMILY SSF50952 33 202 1.27E-17 T 21-04-2016 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SPH21_RS02255 5236b90f9423c3dc426d63ddc4ebb02f 898 SUPERFAMILY SSF50952 229 403 1.27E-17 T 21-04-2016 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SPH21_RS01720 706029046090eb36d99ce33438293d31 138 PANTHER PTHR23091:SF269 13 138 7.1E-27 T 21-04-2016 SPH21_RS01720 706029046090eb36d99ce33438293d31 138 SUPERFAMILY SSF55729 17 136 7.43E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS01720 706029046090eb36d99ce33438293d31 138 PANTHER PTHR23091 13 138 7.1E-27 T 21-04-2016 SPH21_RS01720 706029046090eb36d99ce33438293d31 138 Gene3D G3DSA:3.40.630.30 14 133 3.8E-22 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS01720 706029046090eb36d99ce33438293d31 138 Pfam PF13673 Acetyltransferase (GNAT) domain 37 135 7.3E-17 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS20115 10bcf1b1df8026d0e4798c8d82106085 217 SUPERFAMILY SSF56784 2 214 4.46E-39 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS20115 10bcf1b1df8026d0e4798c8d82106085 217 Gene3D G3DSA:3.40.50.1000 4 19 1.1E-28 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS20115 10bcf1b1df8026d0e4798c8d82106085 217 Gene3D G3DSA:3.40.50.1000 83 214 1.1E-28 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS20115 10bcf1b1df8026d0e4798c8d82106085 217 PANTHER PTHR18901 1 212 1.4E-30 T 21-04-2016 SPH21_RS20115 10bcf1b1df8026d0e4798c8d82106085 217 Pfam PF13419 Haloacid dehalogenase-like hydrolase 8 181 1.5E-31 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 SUPERFAMILY SSF51621 9 289 8.07E-93 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 PANTHER PTHR21631:SF4 1 289 1.0E-138 T 21-04-2016 SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 Gene3D G3DSA:3.20.20.60 8 287 3.2E-93 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 Hamap MF_01939 2-methylisocitrate lyase [prpB]. 4 292 46.734 T 21-04-2016 IPR012695 2-methylisocitrate lyase GO:0019629|GO:0046421 KEGG: 00640+4.1.3.30|MetaCyc: PWY-5747|UniPathway: UPA00946 SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 ProSitePatterns PS00161 Isocitrate lyase signature. 121 126 - T 21-04-2016 IPR018523 Isocitrate lyase/phosphorylmutase, conserved site GO:0003824|GO:0008152 SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 TIGRFAM TIGR02317 prpB: methylisocitrate lyase 7 291 3.3E-120 T 21-04-2016 IPR012695 2-methylisocitrate lyase GO:0019629|GO:0046421 KEGG: 00640+4.1.3.30|MetaCyc: PWY-5747|UniPathway: UPA00946 SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 Pfam PF13714 Phosphoenolpyruvate phosphomutase 11 254 9.9E-51 T 21-04-2016 SPH21_RS20565 36665bc46bfcf505be71b1c616b190c5 293 PANTHER PTHR21631 1 289 1.0E-138 T 21-04-2016 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 Pfam PF01063 Amino-transferase class IV 101 340 9.3E-32 T 21-04-2016 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: REACT_13 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 PANTHER PTHR11825 43 382 5.1E-115 T 21-04-2016 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: REACT_13 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 SUPERFAMILY SSF56752 39 380 1.12E-98 T 21-04-2016 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: REACT_13 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 PANTHER PTHR11825:SF2 43 382 5.1E-115 T 21-04-2016 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 Gene3D G3DSA:3.20.10.10 202 364 4.7E-49 T 21-04-2016 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 TIGRFAM TIGR01123 ilvE_II: branched-chain amino acid aminotransferase 75 381 1.1E-102 T 21-04-2016 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|Reactome: REACT_13 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 Gene3D G3DSA:3.30.470.10 35 201 3.8E-67 T 21-04-2016 SPH21_RS03670 71f4789ef3b67b64d906f767c578941d 384 PIRSF PIRSF006468 31 384 1.1E-112 T 21-04-2016 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|Reactome: REACT_13 SPH21_RS02045 84afde3e3ed1361a9e354e253a1f3891 353 PANTHER PTHR24220 26 292 7.6E-70 T 21-04-2016 SPH21_RS02045 84afde3e3ed1361a9e354e253a1f3891 353 SMART SM00382 52 238 2.9E-15 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02045 84afde3e3ed1361a9e354e253a1f3891 353 Pfam PF00005 ABC transporter 43 189 8.5E-32 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS02045 84afde3e3ed1361a9e354e253a1f3891 353 ProSitePatterns PS00211 ABC transporters family signature. 161 175 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS02045 84afde3e3ed1361a9e354e253a1f3891 353 SUPERFAMILY SSF52540 25 267 5.33E-59 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02045 84afde3e3ed1361a9e354e253a1f3891 353 Gene3D G3DSA:3.40.50.300 24 271 3.8E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 SUPERFAMILY SSF52317 1 198 1.15E-33 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 Gene3D G3DSA:1.10.10.60 224 270 1.4E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 SUPERFAMILY SSF46689 217 268 3.94E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 Pfam PF01965 DJ-1/PfpI family 43 179 1.0E-12 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 PANTHER PTHR11019:SF68 39 325 9.8E-50 T 21-04-2016 SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 Gene3D G3DSA:1.10.10.60 271 321 4.5E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 Pfam PF12833 Helix-turn-helix domain 240 318 2.2E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 Gene3D G3DSA:3.40.50.880 21 223 2.6E-35 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 SUPERFAMILY SSF46689 271 320 3.94E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 PANTHER PTHR11019 39 325 9.8E-50 T 21-04-2016 SPH21_RS01050 67fd4908a0640bfb327145ce618db332 328 SMART SM00342 234 317 4.1E-24 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 SMART SM00646 98 282 3.1E-18 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 Gene3D G3DSA:3.40.630.40 36 159 8.6E-57 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 Gene3D G3DSA:3.40.630.40 211 285 8.6E-57 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 PANTHER PTHR30404:SF0 147 290 5.9E-52 T 21-04-2016 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 PANTHER PTHR30404:SF0 34 118 5.9E-52 T 21-04-2016 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 SUPERFAMILY SSF53187 210 287 9.1E-44 T 21-04-2016 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 SUPERFAMILY SSF53187 36 118 9.1E-44 T 21-04-2016 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 Pfam PF01520 N-acetylmuramoyl-L-alanine amidase 38 282 3.9E-47 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 PANTHER PTHR30404 147 290 5.9E-52 T 21-04-2016 SPH21_RS12570 b4431964a6fd4e1800b126117006172e 290 PANTHER PTHR30404 34 118 5.9E-52 T 21-04-2016 SPH21_RS16350 fa1e4f49125f993fdf3688f9beee6a82 179 Gene3D G3DSA:3.40.50.1000 12 146 2.2E-6 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS16350 fa1e4f49125f993fdf3688f9beee6a82 179 SUPERFAMILY SSF56784 10 146 8.95E-10 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 PANTHER PTHR23416 72 171 6.2E-36 T 21-04-2016 SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 PANTHER PTHR23416 9 52 6.2E-36 T 21-04-2016 SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 Gene3D G3DSA:2.160.10.10 8 168 6.0E-45 T 21-04-2016 SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 PANTHER PTHR23416:SF64 9 52 6.2E-36 T 21-04-2016 SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 PANTHER PTHR23416:SF64 72 171 6.2E-36 T 21-04-2016 SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 81 115 3.3E-11 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 89 117 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS09615 9224a4bb5c33cc3674896249eb130312 180 SUPERFAMILY SSF51161 9 162 2.62E-37 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS17200 26721705886fc8185c264513d8fb9f3c 440 Gene3D G3DSA:3.40.50.720 38 187 4.3E-31 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS17200 26721705886fc8185c264513d8fb9f3c 440 PANTHER PTHR22604:SF92 7 406 2.0E-102 T 21-04-2016 SPH21_RS17200 26721705886fc8185c264513d8fb9f3c 440 SUPERFAMILY SSF51735 25 206 7.9E-31 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS17200 26721705886fc8185c264513d8fb9f3c 440 SUPERFAMILY SSF55347 183 357 5.56E-23 T 21-04-2016 SPH21_RS17200 26721705886fc8185c264513d8fb9f3c 440 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 41 167 9.9E-11 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS17200 26721705886fc8185c264513d8fb9f3c 440 PANTHER PTHR22604 7 406 2.0E-102 T 21-04-2016 SPH21_RS17200 26721705886fc8185c264513d8fb9f3c 440 Gene3D G3DSA:3.30.360.10 188 397 1.5E-36 T 21-04-2016 SPH21_RS14170 af5c6901e6d24f2f81054f121350545e 257 PANTHER PTHR30383 25 256 2.3E-22 T 21-04-2016 SPH21_RS14170 af5c6901e6d24f2f81054f121350545e 257 Gene3D G3DSA:3.40.50.1110 51 255 1.9E-35 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS14170 af5c6901e6d24f2f81054f121350545e 257 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 55 244 1.2E-22 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS14170 af5c6901e6d24f2f81054f121350545e 257 SUPERFAMILY SSF52266 50 255 9.31E-37 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS25190 a972a9d17ddcb4c05040bde13ace0bb5 186 Gene3D G3DSA:3.40.50.1950 4 185 1.3E-70 T 21-04-2016 IPR003382 Flavoprotein GO:0003824 SPH21_RS25190 a972a9d17ddcb4c05040bde13ace0bb5 186 SUPERFAMILY SSF52507 4 184 4.45E-57 T 21-04-2016 IPR003382 Flavoprotein GO:0003824 SPH21_RS25190 a972a9d17ddcb4c05040bde13ace0bb5 186 TIGRFAM TIGR00421 ubiX_pad: polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases 5 184 7.2E-68 T 21-04-2016 IPR004507 Flavin prenyltransferase UbiX/Pad1 SPH21_RS25190 a972a9d17ddcb4c05040bde13ace0bb5 186 Hamap MF_01984 Flavin prenyltransferase UbiX [ubiX]. 4 186 35.424 T 21-04-2016 IPR004507 Flavin prenyltransferase UbiX/Pad1 SPH21_RS25190 a972a9d17ddcb4c05040bde13ace0bb5 186 Pfam PF02441 Flavoprotein 5 128 2.4E-24 T 21-04-2016 IPR003382 Flavoprotein GO:0003824 SPH21_RS25190 a972a9d17ddcb4c05040bde13ace0bb5 186 PANTHER PTHR30108:SF10 4 183 3.3E-82 T 21-04-2016 SPH21_RS25190 a972a9d17ddcb4c05040bde13ace0bb5 186 PANTHER PTHR30108 4 183 3.3E-82 T 21-04-2016 SPH21_RS13775 b0ff402f98c4e8d295ed916675f3b6ad 365 PANTHER PTHR30273 274 365 1.5E-68 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS13775 b0ff402f98c4e8d295ed916675f3b6ad 365 PANTHER PTHR30273 3 256 1.5E-68 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS13775 b0ff402f98c4e8d295ed916675f3b6ad 365 Pfam PF16344 Domain of unknown function (DUF4974) 275 363 7.0E-21 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS13775 b0ff402f98c4e8d295ed916675f3b6ad 365 Pfam PF04773 FecR protein 139 231 8.3E-20 T 21-04-2016 IPR006860 FecR protein SPH21_RS13775 b0ff402f98c4e8d295ed916675f3b6ad 365 PANTHER PTHR30273:SF2 274 365 1.5E-68 T 21-04-2016 SPH21_RS13775 b0ff402f98c4e8d295ed916675f3b6ad 365 PANTHER PTHR30273:SF2 3 256 1.5E-68 T 21-04-2016 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF02796 Helix-turn-helix domain of resolvase 6 44 2.0E-6 T 21-04-2016 IPR006120 Resolvase, HTH domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 75 461 2.1E-85 T 21-04-2016 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 6 55 2.1E-85 T 21-04-2016 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 SUPERFAMILY SSF53098 168 303 2.43E-6 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF00665 Integrase core domain 139 267 1.0E-14 T 21-04-2016 IPR001584 Integrase, catalytic core GO:0015074 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:3.30.420.10 144 302 1.3E-10 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:1.10.10.60 9 43 2.4E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 75 461 2.1E-85 T 21-04-2016 SPH21_RS20675 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 6 55 2.1E-85 T 21-04-2016 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF02796 Helix-turn-helix domain of resolvase 6 44 2.0E-6 T 21-04-2016 IPR006120 Resolvase, HTH domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 75 461 2.1E-85 T 21-04-2016 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 6 55 2.1E-85 T 21-04-2016 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 SUPERFAMILY SSF53098 168 303 2.43E-6 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF00665 Integrase core domain 139 267 1.0E-14 T 21-04-2016 IPR001584 Integrase, catalytic core GO:0015074 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:3.30.420.10 144 302 1.3E-10 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:1.10.10.60 9 43 2.4E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 75 461 2.1E-85 T 21-04-2016 SPH21_RS04210 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 6 55 2.1E-85 T 21-04-2016 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF02796 Helix-turn-helix domain of resolvase 6 44 2.0E-6 T 21-04-2016 IPR006120 Resolvase, HTH domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 75 461 2.1E-85 T 21-04-2016 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 6 55 2.1E-85 T 21-04-2016 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 SUPERFAMILY SSF53098 168 303 2.43E-6 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF00665 Integrase core domain 139 267 1.0E-14 T 21-04-2016 IPR001584 Integrase, catalytic core GO:0015074 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:3.30.420.10 144 302 1.3E-10 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:1.10.10.60 9 43 2.4E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 75 461 2.1E-85 T 21-04-2016 SPH21_RS24405 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 6 55 2.1E-85 T 21-04-2016 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF02796 Helix-turn-helix domain of resolvase 6 44 2.0E-6 T 21-04-2016 IPR006120 Resolvase, HTH domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 75 461 2.1E-85 T 21-04-2016 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004:SF2 6 55 2.1E-85 T 21-04-2016 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 SUPERFAMILY SSF53098 168 303 2.43E-6 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 Pfam PF00665 Integrase core domain 139 267 1.0E-14 T 21-04-2016 IPR001584 Integrase, catalytic core GO:0015074 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:3.30.420.10 144 302 1.3E-10 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 Gene3D G3DSA:1.10.10.60 9 43 2.4E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 75 461 2.1E-85 T 21-04-2016 SPH21_RS21875 995f769cf61dfa4db8b32cf7c54a3ecd 516 PANTHER PTHR35004 6 55 2.1E-85 T 21-04-2016 SPH21_RS20355 ae7ed2d7d837a4eddc9a594d6ae45fab 188 Gene3D G3DSA:3.40.50.300 13 177 1.1E-22 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20355 ae7ed2d7d837a4eddc9a594d6ae45fab 188 SUPERFAMILY SSF52540 8 185 4.96E-15 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20355 ae7ed2d7d837a4eddc9a594d6ae45fab 188 Pfam PF13521 AAA domain 12 175 1.2E-38 T 21-04-2016 SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 Gene3D G3DSA:3.40.50.300 942 1092 3.6E-19 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 SMART SM00490 982 1065 1.3E-18 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 Gene3D G3DSA:3.40.50.300 654 825 3.7E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 Pfam PF00271 Helicase conserved C-terminal domain 954 1065 7.2E-18 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 Pfam PF08455 Bacterial SNF2 helicase associated 336 629 5.1E-7 T 21-04-2016 IPR013663 Helicase, SWF/SNF/SWI type, bacterial SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 SMART SM00487 657 843 2.1E-29 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 Pfam PF00176 SNF2 family N-terminal domain 680 941 1.9E-54 T 21-04-2016 IPR000330 SNF2-related, N-terminal domain GO:0005524 SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 PANTHER PTHR10799 648 1121 1.5E-170 T 21-04-2016 SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 PANTHER PTHR10799 369 375 1.5E-170 T 21-04-2016 SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 SUPERFAMILY SSF52540 631 870 1.23E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02580 2170b29b479f062877fe2cfe7fd4352e 1121 SUPERFAMILY SSF52540 871 1120 4.37E-64 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07950 3a636a19880837d9572239d04f07fc9d 386 PANTHER PTHR11751 16 386 2.4E-115 T 21-04-2016 SPH21_RS07950 3a636a19880837d9572239d04f07fc9d 386 SUPERFAMILY SSF53383 5 384 1.2E-96 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS07950 3a636a19880837d9572239d04f07fc9d 386 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 235 248 - T 21-04-2016 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 Reactome: REACT_13 SPH21_RS07950 3a636a19880837d9572239d04f07fc9d 386 Gene3D G3DSA:3.40.640.10 48 256 4.5E-55 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS07950 3a636a19880837d9572239d04f07fc9d 386 Pfam PF00155 Aminotransferase class I and II 33 382 8.8E-55 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS07950 3a636a19880837d9572239d04f07fc9d 386 PANTHER PTHR11751:SF305 16 386 2.4E-115 T 21-04-2016 SPH21_RS07950 3a636a19880837d9572239d04f07fc9d 386 Gene3D G3DSA:3.90.1150.10 257 384 1.4E-34 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS12695 b3bb729d19e4c36af6970943fd64f916 149 Pfam PF11396 Putative beta-lactamase-inhibitor-like, PepSY-like 56 144 5.7E-10 T 21-04-2016 IPR021533 Putative beta-lactamase-inhibitor-like, PepSY-like SPH21_RS12695 b3bb729d19e4c36af6970943fd64f916 149 SUPERFAMILY SSF160574 23 145 5.1E-23 T 21-04-2016 SPH21_RS04175 2a0a2cbf42a8c41bc19092f62023f795 581 Pfam PF04738 Lantibiotic dehydratase, C terminus 263 575 9.4E-44 T 21-04-2016 IPR006827 Lantibiotic dehydratase, C-terminal SPH21_RS04175 2a0a2cbf42a8c41bc19092f62023f795 581 Pfam PF04738 Lantibiotic dehydratase, C terminus 34 213 1.5E-18 T 21-04-2016 IPR006827 Lantibiotic dehydratase, C-terminal SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 Gene3D G3DSA:2.170.120.20 96 186 2.2E-23 T 21-04-2016 IPR020057 Ribosomal protein L25, beta domain SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 Pfam PF14693 Ribosomal protein TL5, C-terminal domain 99 179 1.5E-21 T 21-04-2016 IPR020057 Ribosomal protein L25, beta domain SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 Pfam PF01386 Ribosomal L25p family 7 90 3.3E-24 T 21-04-2016 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 Gene3D G3DSA:2.40.240.10 4 92 3.1E-27 T 21-04-2016 IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain Reactome: REACT_71 SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 Hamap MF_01334 50S ribosomal protein L25 [rplY]. 4 180 24.317 T 21-04-2016 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 SUPERFAMILY SSF50715 10 179 7.5E-49 T 21-04-2016 IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain GO:0006412 Reactome: REACT_71 SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 PANTHER PTHR33284 10 192 7.6E-43 T 21-04-2016 SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 ProDom PD012503 RIBOSOMAL L25 50S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN STRESS GENERAL CTC RRNA 17 93 4.0E-17 T 21-04-2016 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 SPH21_RS25370 5c18b1d6f4c3063d41c7cbcded53a27a 195 TIGRFAM TIGR00731 bL25_bact_ctc: ribosomal protein bL25, Ctc-form 8 177 8.7E-42 T 21-04-2016 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 7 385 5.5E-135 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 PANTHER PTHR11808:SF36 1 389 3.5E-163 T 21-04-2016 SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 SUPERFAMILY SSF53383 20 386 9.28E-115 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 PIRSF PIRSF001434 1 389 2.6E-129 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 ProSitePatterns PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 196 210 - T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 Gene3D G3DSA:3.40.640.10 11 252 5.7E-87 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 Gene3D G3DSA:3.90.1150.10 253 386 1.6E-50 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS02735 b12b2976e5330e54e5887fc3608a5432 389 PANTHER PTHR11808 1 389 3.5E-163 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 Pfam PF00593 TonB dependent receptor 482 787 2.5E-24 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 SUPERFAMILY SSF49452 31 106 9.81E-10 T 21-04-2016 IPR013784 Carbohydrate-binding-like fold GO:0030246 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 Gene3D G3DSA:2.60.40.1120 34 116 2.7E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 PANTHER PTHR30069:SF2 360 515 2.2E-38 T 21-04-2016 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 PANTHER PTHR30069:SF2 1 344 2.2E-38 T 21-04-2016 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 PANTHER PTHR30069 360 515 2.2E-38 T 21-04-2016 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 PANTHER PTHR30069 1 344 2.2E-38 T 21-04-2016 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 Pfam PF13715 CarboxypepD_reg-like domain 35 118 3.3E-11 T 21-04-2016 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 Gene3D G3DSA:2.170.130.10 117 239 1.1E-30 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 SUPERFAMILY SSF56935 115 651 3.21E-97 T 21-04-2016 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 SUPERFAMILY SSF56935 681 788 3.21E-97 T 21-04-2016 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 Pfam PF07715 TonB-dependent Receptor Plug Domain 133 238 3.8E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18425 1ca3c0795a5af41aaeee03362efcbee3 792 Gene3D G3DSA:2.40.170.20 240 788 2.7E-69 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 52 1137 3.7E-223 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Gene3D G3DSA:2.40.170.20 461 855 1.7E-6 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Gene3D G3DSA:2.40.170.20 342 413 1.7E-6 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Gene3D G3DSA:2.40.170.20 1060 1107 1.7E-6 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Gene3D G3DSA:2.40.170.20 967 1016 1.7E-6 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 SUPERFAMILY SSF49464 51 132 2.49E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Gene3D G3DSA:2.60.40.1120 53 136 1.1E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 237 266 6.1E-14 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 PANTHER PTHR11532 576 907 1.6E-200 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 PANTHER PTHR11532 925 1136 1.6E-200 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 PANTHER PTHR11532 42 474 1.6E-200 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 PANTHER PTHR11532:SF57 576 907 1.6E-200 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 PANTHER PTHR11532:SF57 925 1136 1.6E-200 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 PANTHER PTHR11532:SF57 42 474 1.6E-200 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 SUPERFAMILY SSF56935 557 722 3.8E-57 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 SUPERFAMILY SSF56935 132 288 3.8E-57 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 SUPERFAMILY SSF56935 471 523 3.8E-57 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 SUPERFAMILY SSF56935 1058 1136 3.8E-57 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 SUPERFAMILY SSF56935 751 921 3.8E-57 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 SUPERFAMILY SSF56935 344 413 3.8E-57 T 21-04-2016 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Pfam PF07715 TonB-dependent Receptor Plug Domain 142 260 6.3E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Gene3D G3DSA:2.170.130.10 137 263 5.9E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11365 4bc5865fa17aae582b4efb751c85cf65 1138 Pfam PF13715 CarboxypepD_reg-like domain 53 134 1.0E-18 T 21-04-2016 SPH21_RS21115 09da539450d066f4d276d69b99467f5c 342 SUPERFAMILY SSF46785 18 106 3.18E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21115 09da539450d066f4d276d69b99467f5c 342 PANTHER PTHR38445 44 294 1.3E-20 T 21-04-2016 SPH21_RS21115 09da539450d066f4d276d69b99467f5c 342 SUPERFAMILY SSF53822 114 340 2.64E-11 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS21115 09da539450d066f4d276d69b99467f5c 342 PANTHER PTHR38445:SF1 44 294 1.3E-20 T 21-04-2016 SPH21_RS21115 09da539450d066f4d276d69b99467f5c 342 SMART SM00345 27 86 7.3E-4 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS21115 09da539450d066f4d276d69b99467f5c 342 Gene3D G3DSA:1.10.10.10 17 86 4.2E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21115 09da539450d066f4d276d69b99467f5c 342 Pfam PF00392 Bacterial regulatory proteins, gntR family 27 86 3.6E-7 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS22105 89cd62555c543dd651ccd27aff5ccdfd 230 PANTHER PTHR19372 50 230 7.2E-61 T 21-04-2016 SPH21_RS22105 89cd62555c543dd651ccd27aff5ccdfd 230 Gene3D G3DSA:3.90.420.10 52 228 4.6E-50 T 21-04-2016 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 SPH21_RS22105 89cd62555c543dd651ccd27aff5ccdfd 230 SUPERFAMILY SSF56524 41 229 1.24E-58 T 21-04-2016 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 SPH21_RS22105 89cd62555c543dd651ccd27aff5ccdfd 230 Pfam PF00174 Oxidoreductase molybdopterin binding domain 69 212 1.1E-33 T 21-04-2016 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 9.6E-8 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 9.6E-8 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 9.6E-8 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 PANTHER PTHR30419:SF4 1 302 3.7E-84 T 21-04-2016 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 Gene3D G3DSA:3.40.190.10 90 175 4.3E-20 T 21-04-2016 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 Gene3D G3DSA:1.10.10.10 1 80 7.8E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 PANTHER PTHR30419 1 302 3.7E-84 T 21-04-2016 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 Pfam PF03466 LysR substrate binding domain 87 293 1.1E-36 T 21-04-2016 IPR005119 LysR, substrate-binding SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 62 1.5E-17 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 Gene3D G3DSA:3.40.190.10 176 270 2.0E-19 T 21-04-2016 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 SUPERFAMILY SSF53850 88 299 5.53E-35 T 21-04-2016 SPH21_RS07590 e402774216dcb50d2c1f911e01650dc8 312 SUPERFAMILY SSF46785 1 111 4.43E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 Pfam PF04253 Transferrin receptor-like dimerisation domain 619 727 1.5E-20 T 21-04-2016 IPR007365 Transferrin receptor-like, dimerisation domain SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 Gene3D G3DSA:1.20.930.40 619 729 8.9E-12 T 21-04-2016 IPR007365 Transferrin receptor-like, dimerisation domain SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 SUPERFAMILY SSF47672 556 584 1.48E-26 T 21-04-2016 IPR007365 Transferrin receptor-like, dimerisation domain SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 SUPERFAMILY SSF47672 614 729 1.48E-26 T 21-04-2016 IPR007365 Transferrin receptor-like, dimerisation domain SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 PANTHER PTHR10404 623 733 3.9E-205 T 21-04-2016 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 PANTHER PTHR10404 31 594 3.9E-205 T 21-04-2016 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 Pfam PF02225 PA domain 139 228 1.6E-8 T 21-04-2016 IPR003137 PA domain SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 Pfam PF04389 Peptidase family M28 320 523 5.4E-20 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 SUPERFAMILY SSF53187 39 82 1.03E-65 T 21-04-2016 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 SUPERFAMILY SSF53187 304 554 1.03E-65 T 21-04-2016 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 Gene3D G3DSA:3.50.30.30 113 301 1.7E-53 T 21-04-2016 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 Gene3D G3DSA:3.40.630.10 28 88 7.7E-83 T 21-04-2016 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 Gene3D G3DSA:3.40.630.10 305 559 7.7E-83 T 21-04-2016 SPH21_RS13245 c4ddbce44406cb5f5edd2914214486a1 733 SUPERFAMILY SSF52025 88 322 2.49E-68 T 21-04-2016 SPH21_RS10545 0c42953261048d59603b5b888a5638b3 61 PIRSF PIRSF039008 1 61 4.6E-21 T 21-04-2016 IPR026042 Stress response protein YjbJ SPH21_RS10545 0c42953261048d59603b5b888a5638b3 61 Pfam PF05532 CsbD-like 5 54 6.2E-20 T 21-04-2016 IPR008462 CsbD-like SPH21_RS10545 0c42953261048d59603b5b888a5638b3 61 Gene3D G3DSA:1.10.1470.10 1 59 3.6E-22 T 21-04-2016 IPR008462 CsbD-like SPH21_RS10545 0c42953261048d59603b5b888a5638b3 61 SUPERFAMILY SSF69047 1 59 2.35E-19 T 21-04-2016 IPR008462 CsbD-like SPH21_RS00490 87459a29e01d761b177c1d3d93ae4a0e 91 SUPERFAMILY SSF46955 38 84 1.41E-5 T 21-04-2016 IPR009061 Putative DNA-binding domain SPH21_RS00490 87459a29e01d761b177c1d3d93ae4a0e 91 PANTHER PTHR34585 1 85 5.5E-15 T 21-04-2016 SPH21_RS00490 87459a29e01d761b177c1d3d93ae4a0e 91 Pfam PF12728 Helix-turn-helix domain 38 86 8.8E-9 T 21-04-2016 SPH21_RS16080 5cd9486a484a2d6be4434d1f662226f0 786 Pfam PF12740 Chlorophyllase enzyme 266 429 1.7E-7 T 21-04-2016 IPR017395 Chlorophyllase GO:0015996|GO:0047746 KEGG: 00860+3.1.1.14|MetaCyc: PWY-5098|MetaCyc: PWY-6927|MetaCyc: PWY-7164|UniPathway: UPA00674 SPH21_RS16080 5cd9486a484a2d6be4434d1f662226f0 786 Gene3D G3DSA:3.40.50.1820 245 535 7.4E-26 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS16080 5cd9486a484a2d6be4434d1f662226f0 786 SUPERFAMILY SSF53474 261 488 1.55E-17 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 SUPERFAMILY SSF46785 18 90 6.39E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 PANTHER PTHR11751 25 89 2.8E-16 T 21-04-2016 SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 PANTHER PTHR11751 105 128 2.8E-16 T 21-04-2016 SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 SMART SM00345 27 86 1.2E-14 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 Gene3D G3DSA:1.20.120.530 109 228 2.4E-10 T 21-04-2016 IPR008920 Transcription regulator FadR/GntR, C-terminal SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 Pfam PF00392 Bacterial regulatory proteins, gntR family 24 84 5.9E-17 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 Gene3D G3DSA:1.10.10.10 22 90 8.1E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 Pfam PF07729 FCD domain 111 227 3.5E-8 T 21-04-2016 IPR011711 GntR, C-terminal SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 SUPERFAMILY SSF48008 109 233 1.05E-11 T 21-04-2016 IPR008920 Transcription regulator FadR/GntR, C-terminal SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 46 60 2.2E-8 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS13635 23a45fa702758bf8d17ac3ddc76e94dc 239 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 60 76 2.2E-8 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 PANTHER PTHR11136:SF0 22 434 1.3E-113 T 21-04-2016 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 Gene3D G3DSA:3.40.1190.10 3 298 1.4E-86 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 PANTHER PTHR11136 22 434 1.3E-113 T 21-04-2016 IPR001645 Folylpolyglutamate synthetase GO:0004326|GO:0005524|GO:0009396 KEGG: 00790+6.3.2.17|MetaCyc: PWY-2161|UniPathway: UPA00850 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 Gene3D G3DSA:3.90.190.20 305 433 7.5E-28 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 SUPERFAMILY SSF53244 303 432 5.49E-20 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 SUPERFAMILY SSF53623 1 298 2.4E-83 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 PIRSF PIRSF001563 10 434 6.0E-112 T 21-04-2016 IPR001645 Folylpolyglutamate synthetase GO:0004326|GO:0005524|GO:0009396 KEGG: 00790+6.3.2.17|MetaCyc: PWY-2161|UniPathway: UPA00850 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 ProSitePatterns PS01012 Folylpolyglutamate synthase signature 2. 141 156 - T 21-04-2016 IPR018109 Folylpolyglutamate synthetase, conserved site GO:0004326|GO:0005524|GO:0009396 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 Pfam PF08245 Mur ligase middle domain 51 269 3.9E-13 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS10940 467c2f0457976ba786371cbab80408ee 434 TIGRFAM TIGR01499 folC: bifunctional protein FolC 29 430 1.3E-107 T 21-04-2016 IPR001645 Folylpolyglutamate synthetase GO:0004326|GO:0005524|GO:0009396 KEGG: 00790+6.3.2.17|MetaCyc: PWY-2161|UniPathway: UPA00850 SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 SUPERFAMILY SSF69304 304 580 1.7E-39 T 21-04-2016 SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 Pfam PF04450 Peptidase of plants and bacteria 135 269 9.2E-6 T 21-04-2016 IPR007541 Uncharacterised protein family, basic secretory protein SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 Gene3D G3DSA:2.130.10.10 300 593 9.0E-46 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 Pfam PF07676 WD40-like Beta Propeller Repeat 404 428 0.0016 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 Pfam PF07676 WD40-like Beta Propeller Repeat 297 321 4.1E-4 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 Pfam PF07676 WD40-like Beta Propeller Repeat 437 465 1.9E-4 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 Pfam PF07676 WD40-like Beta Propeller Repeat 499 528 0.0013 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS15495 f418fb556fdccc64012d9f8536259e0b 1043 PANTHER PTHR36842 351 772 2.8E-14 T 21-04-2016 SPH21_RS22415 69cad681fc2c9570f972a94f311e05fe 218 SUPERFAMILY SSF161098 9 201 4.71E-47 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS22415 69cad681fc2c9570f972a94f311e05fe 218 PANTHER PTHR30450 1 218 1.3E-115 T 21-04-2016 SPH21_RS22415 69cad681fc2c9570f972a94f311e05fe 218 PANTHER PTHR30450:SF1 1 218 1.3E-115 T 21-04-2016 SPH21_RS22415 69cad681fc2c9570f972a94f311e05fe 218 Gene3D G3DSA:1.10.3720.10 9 216 2.3E-43 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS22415 69cad681fc2c9570f972a94f311e05fe 218 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 39 216 7.5E-22 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 Gene3D G3DSA:1.10.340.30 124 243 1.1E-27 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 PANTHER PTHR10242:SF3 6 48 4.8E-56 T 21-04-2016 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 PANTHER PTHR10242:SF3 69 296 4.8E-56 T 21-04-2016 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 PANTHER PTHR10242 6 48 4.8E-56 T 21-04-2016 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 PANTHER PTHR10242 69 296 4.8E-56 T 21-04-2016 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 SUPERFAMILY SSF48150 112 296 1.33E-35 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 SMART SM00478 132 297 1.4E-15 T 21-04-2016 IPR003265 HhH-GPD domain GO:0006284 Reactome: REACT_216 SPH21_RS25170 a2c3941ee8c6121858fd7831c6d6de94 309 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 128 270 2.8E-12 T 21-04-2016 IPR003265 HhH-GPD domain GO:0006284 Reactome: REACT_216 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 Pfam PF01676 Metalloenzyme superfamily 2 493 9.0E-75 T 21-04-2016 IPR006124 Metalloenzyme GO:0003824|GO:0046872 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 SUPERFAMILY SSF64158 75 299 1.7E-76 T 21-04-2016 IPR011258 BPG-independent PGAM, N-terminal GO:0004619|GO:0005737|GO:0006007|GO:0030145 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 Pfam PF06415 BPG-independent PGAM N-terminus (iPGM_N) 80 295 6.2E-79 T 21-04-2016 IPR011258 BPG-independent PGAM, N-terminal GO:0004619|GO:0005737|GO:0006007|GO:0030145 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 Hamap MF_01038 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [gpmI]. 2 506 46.429 T 21-04-2016 IPR005995 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent GO:0004619|GO:0006007 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 PIRSF PIRSF001492 1 506 5.4E-199 T 21-04-2016 IPR005995 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent GO:0004619|GO:0006007 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 Gene3D G3DSA:3.40.1450.10 76 307 1.1E-87 T 21-04-2016 IPR011258 BPG-independent PGAM, N-terminal GO:0004619|GO:0005737|GO:0006007|GO:0030145 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 PANTHER PTHR31637:SF0 2 505 8.0E-249 T 21-04-2016 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 Gene3D G3DSA:3.40.720.10 1 75 9.7E-85 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 Gene3D G3DSA:3.40.720.10 311 505 9.7E-85 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 PANTHER PTHR31637 2 505 8.0E-249 T 21-04-2016 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 SUPERFAMILY SSF53649 307 505 2.22E-69 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 SUPERFAMILY SSF53649 1 75 2.22E-69 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS14870 ea2a024a4b1ac8427eb5bf51d46cf182 506 TIGRFAM TIGR01307 pgm_bpd_ind: phosphoglycerate mutase (2,3-diphosphoglycerate-independent) 2 504 1.9E-196 T 21-04-2016 IPR005995 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent GO:0004619|GO:0006007 KEGG: 00010+5.4.2.12|KEGG: 00260+5.4.2.12|KEGG: 00680+5.4.2.12|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|UniPathway: UPA00109 SPH21_RS00620 39b58b1ed0fd2cf9853a5585f77ce535 370 Pfam PF12697 Alpha/beta hydrolase family 94 262 6.2E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS00620 39b58b1ed0fd2cf9853a5585f77ce535 370 Gene3D G3DSA:3.40.50.1820 33 369 8.6E-106 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00620 39b58b1ed0fd2cf9853a5585f77ce535 370 PANTHER PTHR11177:SF162 114 357 1.9E-64 T 21-04-2016 SPH21_RS00620 39b58b1ed0fd2cf9853a5585f77ce535 370 SUPERFAMILY SSF53474 73 365 2.39E-26 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00620 39b58b1ed0fd2cf9853a5585f77ce535 370 PANTHER PTHR11177 114 357 1.9E-64 T 21-04-2016 SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PANTHER PTHR24322 159 190 3.0E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PANTHER PTHR24322 13 143 3.0E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 9 195 0.0031 T 21-04-2016 SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 146 174 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 8.2E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 8.2E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 8.2E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 8.2E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 8.2E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PIRSF PIRSF000126 1 268 4.4E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 Pfam PF00106 short chain dehydrogenase 9 198 2.4E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 Gene3D G3DSA:3.40.50.720 3 231 7.9E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 SUPERFAMILY SSF51735 3 239 2.49E-48 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PANTHER PTHR24322:SF631 159 190 3.0E-33 T 21-04-2016 SPH21_RS11920 e0e82ada55d320dbd9e6146327473739 269 PANTHER PTHR24322:SF631 13 143 3.0E-33 T 21-04-2016 SPH21_RS12225 e4ea88775bc99c236019c49ff0119290 243 Pfam PF00535 Glycosyl transferase family 2 6 171 4.4E-25 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS12225 e4ea88775bc99c236019c49ff0119290 243 PANTHER PTHR10859 6 240 3.9E-62 T 21-04-2016 SPH21_RS12225 e4ea88775bc99c236019c49ff0119290 243 Gene3D G3DSA:3.90.550.10 6 232 2.4E-20 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12225 e4ea88775bc99c236019c49ff0119290 243 SUPERFAMILY SSF53448 6 231 7.31E-41 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS05585 2a63091ac418ddddec5c4b0f23bd05c3 228 PANTHER PTHR11907:SF9 1 225 1.8E-34 T 21-04-2016 SPH21_RS05585 2a63091ac418ddddec5c4b0f23bd05c3 228 PANTHER PTHR11907 1 225 1.8E-34 T 21-04-2016 SPH21_RS05585 2a63091ac418ddddec5c4b0f23bd05c3 228 Pfam PF00156 Phosphoribosyl transferase domain 163 225 3.8E-6 T 21-04-2016 IPR000836 Phosphoribosyltransferase domain GO:0009116 SPH21_RS05585 2a63091ac418ddddec5c4b0f23bd05c3 228 SUPERFAMILY SSF53271 71 226 1.7E-24 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS05585 2a63091ac418ddddec5c4b0f23bd05c3 228 Gene3D G3DSA:3.40.50.2020 30 226 2.0E-29 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 157 180 7.1E-5 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 124 155 3.1E-9 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 224 259 3.6E-6 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Gene3D G3DSA:2.160.10.10 209 310 2.4E-20 T 21-04-2016 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 SUPERFAMILY SSF51161 31 317 1.03E-75 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Hamap MF_00523 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase [lpxD]. 4 328 34.597 T 21-04-2016 IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD GO:0009245|GO:0016410 UniPathway: UPA00973 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Gene3D G3DSA:2.160.10.10 108 208 9.3E-28 T 21-04-2016 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 TIGRFAM TIGR01853 lipid_A_lpxD: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD 7 331 3.8E-109 T 21-04-2016 IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD GO:0009245|GO:0016410 UniPathway: UPA00973 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 PANTHER PTHR22572 100 297 2.1E-60 T 21-04-2016 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 261 289 0.23 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS07620 1260ac67e0166937c296184598d65628 345 PANTHER PTHR22572:SF117 100 297 2.1E-60 T 21-04-2016 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 131 159 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 101 129 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS07620 1260ac67e0166937c296184598d65628 345 Pfam PF04613 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD 21 89 2.8E-19 T 21-04-2016 IPR020573 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, non-repeat region GO:0009245|GO:0016747 UniPathway: UPA00973 SPH21_RS15745 95566f22d3dda85d03b057ef132a620d 289 Pfam PF03279 Bacterial lipid A biosynthesis acyltransferase 7 284 4.3E-45 T 21-04-2016 IPR004960 Bacterial lipid A biosynthesis acyltransferase GO:0016021|GO:0016740 SPH21_RS15745 95566f22d3dda85d03b057ef132a620d 289 PANTHER PTHR30606 7 287 1.5E-52 T 21-04-2016 SPH21_RS15745 95566f22d3dda85d03b057ef132a620d 289 PIRSF PIRSF026649 1 289 1.3E-64 T 21-04-2016 IPR004960 Bacterial lipid A biosynthesis acyltransferase GO:0016021|GO:0016740 SPH21_RS03980 da31d4b98d5c7aff08bf43875652ef43 593 SUPERFAMILY SSF69318 322 552 3.4E-16 T 21-04-2016 SPH21_RS03980 da31d4b98d5c7aff08bf43875652ef43 593 Gene3D G3DSA:3.60.21.10 32 262 1.1E-16 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS03980 da31d4b98d5c7aff08bf43875652ef43 593 PANTHER PTHR39431:SF2 413 555 3.1E-17 T 21-04-2016 SPH21_RS03980 da31d4b98d5c7aff08bf43875652ef43 593 PANTHER PTHR39431 413 555 3.1E-17 T 21-04-2016 SPH21_RS03980 da31d4b98d5c7aff08bf43875652ef43 593 Pfam PF00149 Calcineurin-like phosphoesterase 35 259 1.5E-9 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS03980 da31d4b98d5c7aff08bf43875652ef43 593 SUPERFAMILY SSF56300 33 263 1.64E-22 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS03800 cd3be62430361a3af6a3162702222cc5 287 SMART SM00644 74 205 4.7E-27 T 21-04-2016 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SPH21_RS03800 cd3be62430361a3af6a3162702222cc5 287 PANTHER PTHR30417 66 262 7.5E-43 T 21-04-2016 SPH21_RS03800 cd3be62430361a3af6a3162702222cc5 287 Gene3D G3DSA:3.40.80.10 67 224 2.9E-50 T 21-04-2016 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SPH21_RS03800 cd3be62430361a3af6a3162702222cc5 287 SUPERFAMILY SSF55846 72 221 2.75E-46 T 21-04-2016 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SPH21_RS03800 cd3be62430361a3af6a3162702222cc5 287 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 81 205 4.9E-23 T 21-04-2016 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SPH21_RS16650 04e89183eea1326ed6cb3588f6b77b93 188 Gene3D G3DSA:3.40.1740.10 128 175 1.7E-27 T 21-04-2016 SPH21_RS16650 04e89183eea1326ed6cb3588f6b77b93 188 Gene3D G3DSA:3.40.1740.10 4 46 1.7E-27 T 21-04-2016 SPH21_RS16650 04e89183eea1326ed6cb3588f6b77b93 188 PANTHER PTHR30327 1 188 1.6E-41 T 21-04-2016 SPH21_RS16650 04e89183eea1326ed6cb3588f6b77b93 188 SUPERFAMILY SSF143456 7 184 1.15E-47 T 21-04-2016 SPH21_RS16650 04e89183eea1326ed6cb3588f6b77b93 188 Pfam PF02622 Uncharacterized ACR, COG1678 17 172 3.2E-41 T 21-04-2016 IPR003774 Protein of unknown function UPF0301 SPH21_RS16650 04e89183eea1326ed6cb3588f6b77b93 188 PANTHER PTHR30327:SF1 1 188 1.6E-41 T 21-04-2016 SPH21_RS16650 04e89183eea1326ed6cb3588f6b77b93 188 Gene3D G3DSA:3.30.70.1300 59 127 6.2E-6 T 21-04-2016 SPH21_RS18820 4e7398f306d34546b9eeeba0a1b0f7e0 363 PANTHER PTHR30160:SF1 1 360 8.0E-45 T 21-04-2016 SPH21_RS18820 4e7398f306d34546b9eeeba0a1b0f7e0 363 PANTHER PTHR30160 1 360 8.0E-45 T 21-04-2016 SPH21_RS18820 4e7398f306d34546b9eeeba0a1b0f7e0 363 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 89 317 6.2E-29 T 21-04-2016 IPR002201 Glycosyl transferase, family 9 GO:0008152|GO:0016757 SPH21_RS18820 4e7398f306d34546b9eeeba0a1b0f7e0 363 Gene3D G3DSA:3.40.50.2000 180 361 2.2E-38 T 21-04-2016 SPH21_RS18820 4e7398f306d34546b9eeeba0a1b0f7e0 363 SUPERFAMILY SSF53756 10 361 8.32E-67 T 21-04-2016 SPH21_RS18820 4e7398f306d34546b9eeeba0a1b0f7e0 363 Gene3D G3DSA:3.40.50.2000 10 159 7.2E-20 T 21-04-2016 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 TIGRFAM TIGR02817 adh_fam_1: zinc-binding alcohol dehydrogenase family protein 2 334 1.1E-134 T 21-04-2016 IPR014182 Alcohol dehydrogenase, zinc-binding type 1 GO:0008270 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 PANTHER PTHR11695:SF558 18 336 2.9E-115 T 21-04-2016 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 150 171 - T 21-04-2016 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 PANTHER PTHR11695 18 336 2.9E-115 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 Gene3D G3DSA:3.90.180.10 21 157 1.0E-36 T 21-04-2016 IPR011032 GroES-like SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 SMART SM00829 14 334 5.9E-11 T 21-04-2016 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 SUPERFAMILY SSF50129 13 154 5.17E-31 T 21-04-2016 IPR011032 GroES-like SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 SUPERFAMILY SSF51735 119 288 2.39E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 32 92 2.2E-7 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 Pfam PF13602 Zinc-binding dehydrogenase 194 334 5.7E-22 T 21-04-2016 SPH21_RS20610 ab9868af2fad5918350fd87dea2824d7 336 Gene3D G3DSA:3.40.50.720 158 263 1.2E-20 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05735 438709462aac21bf3787b689b1bb9bbb 200 Pfam PF01351 Ribonuclease HII 13 188 1.2E-37 T 21-04-2016 IPR024567 Ribonuclease HII/HIII domain SPH21_RS05735 438709462aac21bf3787b689b1bb9bbb 200 Gene3D G3DSA:3.30.420.10 13 151 1.1E-44 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS05735 438709462aac21bf3787b689b1bb9bbb 200 Hamap MF_00052_B Ribonuclease HII [rnhB]. 11 191 33.222 T 21-04-2016 IPR022898 Ribonuclease HII GO:0004523 SPH21_RS05735 438709462aac21bf3787b689b1bb9bbb 200 PANTHER PTHR10954 1 189 5.9E-64 T 21-04-2016 IPR001352 Ribonuclease HII/HIII GO:0003723|GO:0004523 SPH21_RS05735 438709462aac21bf3787b689b1bb9bbb 200 SUPERFAMILY SSF53098 5 195 3.03E-63 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS23040 0becbe3eccd7113627d9877dd280b9c6 150 PANTHER PTHR10545 6 150 2.8E-48 T 21-04-2016 SPH21_RS23040 0becbe3eccd7113627d9877dd280b9c6 150 SUPERFAMILY SSF55729 5 145 2.45E-36 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23040 0becbe3eccd7113627d9877dd280b9c6 150 Gene3D G3DSA:3.40.630.30 4 149 2.4E-49 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23040 0becbe3eccd7113627d9877dd280b9c6 150 Pfam PF00583 Acetyltransferase (GNAT) family 57 135 8.7E-14 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS23765 495a67813d2b741e310c47741ae2f681 120 PANTHER PTHR33204 1 120 2.4E-32 T 21-04-2016 SPH21_RS23765 495a67813d2b741e310c47741ae2f681 120 Pfam PF01638 HxlR-like helix-turn-helix 21 108 8.1E-28 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS23765 495a67813d2b741e310c47741ae2f681 120 SUPERFAMILY SSF46785 6 110 1.56E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23765 495a67813d2b741e310c47741ae2f681 120 Gene3D G3DSA:1.10.10.10 2 110 1.9E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 PANTHER PTHR11772:SF11 2 538 5.1E-280 T 21-04-2016 SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 PANTHER PTHR11772 2 538 5.1E-280 T 21-04-2016 SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 Gene3D G3DSA:3.60.20.10 1 192 1.9E-67 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 TIGRFAM TIGR01536 asn_synth_AEB: asparagine synthase (glutamine-hydrolyzing) 2 372 9.8E-117 T 21-04-2016 IPR006426 Asparagine synthase, glutamine-hydrolyzing GO:0004066|GO:0006529 KEGG: 00250+6.3.5.4|UniPathway: UPA00134 SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 Pfam PF13537 Glutamine amidotransferase domain 48 165 7.6E-41 T 21-04-2016 IPR017932 Glutamine amidotransferase type 2 domain SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 SUPERFAMILY SSF56235 1 193 1.29E-57 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 SUPERFAMILY SSF52402 206 481 5.24E-78 T 21-04-2016 SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 Pfam PF00733 Asparagine synthase 367 511 4.8E-40 T 21-04-2016 IPR001962 Asparagine synthase GO:0004066|GO:0006529 SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 Pfam PF00733 Asparagine synthase 212 366 2.5E-57 T 21-04-2016 IPR001962 Asparagine synthase GO:0004066|GO:0006529 SPH21_RS16470 90327a3cfb511a13da2e76e4ae7404c3 561 Gene3D G3DSA:3.40.50.620 193 511 3.4E-117 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS22330 6bab0d9e2d8b6851f6b25ca185658681 142 Pfam PF00571 CBS domain 72 126 8.4E-15 T 21-04-2016 IPR000644 CBS domain SPH21_RS22330 6bab0d9e2d8b6851f6b25ca185658681 142 Pfam PF00571 CBS domain 13 60 3.5E-10 T 21-04-2016 IPR000644 CBS domain SPH21_RS22330 6bab0d9e2d8b6851f6b25ca185658681 142 Gene3D G3DSA:3.10.580.10 12 127 1.3E-35 T 21-04-2016 SPH21_RS22330 6bab0d9e2d8b6851f6b25ca185658681 142 SMART SM00116 79 126 2.6E-7 T 21-04-2016 IPR000644 CBS domain SPH21_RS22330 6bab0d9e2d8b6851f6b25ca185658681 142 SMART SM00116 14 61 4.7E-9 T 21-04-2016 IPR000644 CBS domain SPH21_RS22330 6bab0d9e2d8b6851f6b25ca185658681 142 PANTHER PTHR11911 13 140 1.9E-38 T 21-04-2016 SPH21_RS22330 6bab0d9e2d8b6851f6b25ca185658681 142 SUPERFAMILY SSF54631 10 140 1.77E-36 T 21-04-2016 SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 Gene3D G3DSA:1.10.1740.10 7 117 1.9E-14 T 21-04-2016 SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 180 1.2E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 PANTHER PTHR30173 2 181 2.1E-22 T 21-04-2016 SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 Pfam PF08281 Sigma-70, region 4 124 176 1.3E-9 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 Gene3D G3DSA:1.10.10.10 118 182 5.4E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 SUPERFAMILY SSF88946 5 101 1.69E-14 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 Pfam PF04542 Sigma-70 region 2 27 95 4.5E-8 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS00730 d3f8ad4380596172d3f16d16f5532f01 189 SUPERFAMILY SSF88659 109 182 1.1E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 SUPERFAMILY SSF46894 140 207 4.42E-12 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 SUPERFAMILY SSF52172 2 123 2.56E-15 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 Pfam PF00072 Response regulator receiver domain 6 112 1.5E-6 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 PANTHER PTHR26402 3 203 6.8E-23 T 21-04-2016 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 PANTHER PTHR26402:SF151 3 203 6.8E-23 T 21-04-2016 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 Pfam PF00196 Bacterial regulatory proteins, luxR family 149 201 4.7E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 SMART SM00421 147 204 1.6E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 Gene3D G3DSA:3.40.50.2300 2 117 1.5E-12 T 21-04-2016 SPH21_RS18975 5e7469182ff31672d9d5aaf19d69734e 212 Gene3D G3DSA:1.10.10.10 118 210 3.9E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22610 b332007ed5f100b0e0c6ad713e7b6a45 223 SMART SM00867 40 221 5.4E-20 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS22610 b332007ed5f100b0e0c6ad713e7b6a45 223 PANTHER PTHR34406:SF1 33 222 4.9E-12 T 21-04-2016 SPH21_RS22610 b332007ed5f100b0e0c6ad713e7b6a45 223 Gene3D G3DSA:2.40.128.110 40 223 1.4E-38 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS22610 b332007ed5f100b0e0c6ad713e7b6a45 223 PANTHER PTHR34406 33 222 4.9E-12 T 21-04-2016 SPH21_RS22610 b332007ed5f100b0e0c6ad713e7b6a45 223 Pfam PF04264 YceI-like domain 41 220 5.5E-31 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS22610 b332007ed5f100b0e0c6ad713e7b6a45 223 SUPERFAMILY SSF101874 40 223 5.62E-32 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Pfam PF13715 CarboxypepD_reg-like domain 149 229 2.0E-15 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Pfam PF07715 TonB-dependent Receptor Plug Domain 237 344 7.2E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Gene3D G3DSA:2.40.170.20 431 510 2.0E-34 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Gene3D G3DSA:2.40.170.20 346 379 2.0E-34 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Gene3D G3DSA:2.40.170.20 963 996 2.0E-34 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Gene3D G3DSA:2.40.170.20 542 902 2.0E-34 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Gene3D G3DSA:2.40.170.20 1029 1114 2.0E-34 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Gene3D G3DSA:2.170.130.10 232 345 5.0E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 147 1114 1.7E-249 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 PANTHER PTHR11532 614 641 3.8E-231 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 PANTHER PTHR11532 134 537 3.8E-231 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 PANTHER PTHR11532 678 1112 3.8E-231 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 320 350 2.4E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 PANTHER PTHR11532:SF57 614 641 3.8E-231 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 PANTHER PTHR11532:SF57 134 537 3.8E-231 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 PANTHER PTHR11532:SF57 678 1112 3.8E-231 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 SUPERFAMILY SSF56935 226 368 3.11E-86 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 SUPERFAMILY SSF56935 540 890 3.11E-86 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 SUPERFAMILY SSF56935 953 998 3.11E-86 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 SUPERFAMILY SSF56935 1030 1114 3.11E-86 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 SUPERFAMILY SSF56935 424 512 3.11E-86 T 21-04-2016 SPH21_RS02425 64eb694966355aa0a759533257237127 1114 SUPERFAMILY SSF49464 147 227 1.7E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02425 64eb694966355aa0a759533257237127 1114 Gene3D G3DSA:2.60.40.1120 149 231 2.2E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS20390 07ec31515f4499e996f508bcbaa2400b 150 SUPERFAMILY SSF54593 26 146 9.53E-23 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS20390 07ec31515f4499e996f508bcbaa2400b 150 PANTHER PTHR10374 15 146 5.0E-14 T 21-04-2016 SPH21_RS20390 07ec31515f4499e996f508bcbaa2400b 150 Gene3D G3DSA:3.10.180.10 28 146 2.7E-24 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS20390 07ec31515f4499e996f508bcbaa2400b 150 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 28 146 2.0E-10 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 Gene3D G3DSA:3.40.50.1970 4 167 9.7E-56 T 21-04-2016 SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 PANTHER PTHR21090 30 351 3.6E-118 T 21-04-2016 SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 TIGRFAM TIGR01357 aroB: 3-dehydroquinate synthase 18 345 3.6E-102 T 21-04-2016 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164|UniPathway: UPA00053 SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 PIRSF PIRSF001455 2 352 1.4E-101 T 21-04-2016 IPR030963 3-dehydroquinate synthase family GO:0009073|GO:0016838 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164|UniPathway: UPA00053 SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 SUPERFAMILY SSF56796 12 347 4.06E-87 T 21-04-2016 SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 Gene3D G3DSA:1.20.1090.10 168 348 5.7E-47 T 21-04-2016 SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 1 349 33.077 T 21-04-2016 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164|UniPathway: UPA00053 SPH21_RS11210 795dcae5043260cabd7ed11d84fe1a35 355 Pfam PF01761 3-dehydroquinate synthase 62 316 5.6E-86 T 21-04-2016 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164|UniPathway: UPA00053 SPH21_RS11285 1940af6842c57092cd70ec6025f1322f 84 TIGRFAM TIGR01216 ATP_synt_epsi: ATP synthase F1, epsilon subunit 1 81 3.2E-24 T 21-04-2016 IPR001469 ATPase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS11285 1940af6842c57092cd70ec6025f1322f 84 Gene3D G3DSA:2.60.15.10 1 83 7.3E-27 T 21-04-2016 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS11285 1940af6842c57092cd70ec6025f1322f 84 Pfam PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 1 78 7.9E-26 T 21-04-2016 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS11285 1940af6842c57092cd70ec6025f1322f 84 ProDom PD000944 ATP SYNTHASE ION EPSILON SUBUNIT HYDROLASE CF1 SYNTHESIS CHAIN HYDROGEN 6 47 3.0E-7 T 21-04-2016 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS11285 1940af6842c57092cd70ec6025f1322f 84 SUPERFAMILY SSF51344 1 80 9.29E-21 T 21-04-2016 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS11285 1940af6842c57092cd70ec6025f1322f 84 PANTHER PTHR13822 1 83 7.2E-19 T 21-04-2016 IPR001469 ATPase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS21790 3995e21f7bc20d123e06050d2c2db471 403 SUPERFAMILY SSF52540 40 205 1.48E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21790 3995e21f7bc20d123e06050d2c2db471 403 Pfam PF13635 Domain of unknown function (DUF4143) 203 346 1.2E-11 T 21-04-2016 IPR025420 Domain of unknown function DUF4143 SPH21_RS21790 3995e21f7bc20d123e06050d2c2db471 403 Gene3D G3DSA:3.40.50.300 40 148 3.6E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21790 3995e21f7bc20d123e06050d2c2db471 403 Pfam PF13173 AAA domain 40 159 4.8E-33 T 21-04-2016 SPH21_RS21790 3995e21f7bc20d123e06050d2c2db471 403 PANTHER PTHR33295 26 399 5.2E-109 T 21-04-2016 SPH21_RS21790 3995e21f7bc20d123e06050d2c2db471 403 PANTHER PTHR33295:SF6 26 399 5.2E-109 T 21-04-2016 SPH21_RS19875 95e584f130e6b518d565b1b9425f4192 115 Pfam PF02699 Preprotein translocase subunit 17 92 2.5E-28 T 21-04-2016 IPR003849 Preprotein translocase YajC SPH21_RS19875 95e584f130e6b518d565b1b9425f4192 115 PRINTS PR01853 Bacterial YajC preprotein translocase signature 15 35 4.4E-13 T 21-04-2016 IPR003849 Preprotein translocase YajC SPH21_RS19875 95e584f130e6b518d565b1b9425f4192 115 PRINTS PR01853 Bacterial YajC preprotein translocase signature 53 71 4.4E-13 T 21-04-2016 IPR003849 Preprotein translocase YajC SPH21_RS19875 95e584f130e6b518d565b1b9425f4192 115 TIGRFAM TIGR00739 yajC: preprotein translocase, YajC subunit 15 92 6.1E-27 T 21-04-2016 IPR003849 Preprotein translocase YajC SPH21_RS19875 95e584f130e6b518d565b1b9425f4192 115 PANTHER PTHR33909 13 91 8.0E-25 T 21-04-2016 SPH21_RS19875 95e584f130e6b518d565b1b9425f4192 115 SMART SM01323 13 95 2.0E-37 T 21-04-2016 IPR003849 Preprotein translocase YajC SPH21_RS19875 95e584f130e6b518d565b1b9425f4192 115 PANTHER PTHR33909:SF1 13 91 8.0E-25 T 21-04-2016 SPH21_RS03630 16baee9348c06518b1164d7581079391 145 Pfam PF04536 Acid phosphatase of thylakoid lumen protein 2 116 4.8E-19 T 21-04-2016 IPR007621 TPM domain SPH21_RS03630 16baee9348c06518b1164d7581079391 145 PANTHER PTHR30373 3 136 4.0E-19 T 21-04-2016 SPH21_RS03630 16baee9348c06518b1164d7581079391 145 PANTHER PTHR30373:SF3 3 136 4.0E-19 T 21-04-2016 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 SUPERFAMILY SSF88659 111 179 1.53E-11 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 PANTHER PTHR30173 1 194 4.9E-39 T 21-04-2016 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 Gene3D G3DSA:1.10.1740.10 5 89 3.7E-13 T 21-04-2016 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 Pfam PF08281 Sigma-70, region 4 124 174 1.4E-12 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 Pfam PF04542 Sigma-70 region 2 42 88 6.4E-5 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 177 3.0E-16 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 SUPERFAMILY SSF88946 6 89 1.1E-12 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 Gene3D G3DSA:1.10.10.10 118 181 6.6E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14620 628979df9b212974dc3afaffd201ada9 195 PANTHER PTHR30173:SF20 1 194 4.9E-39 T 21-04-2016 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 Pfam PF00672 HAMP domain 159 227 8.8E-11 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 SMART SM00388 232 298 4.5E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 SMART SM00304 178 231 7.1E-8 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 SUPERFAMILY SSF55874 288 454 1.7E-33 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 SUPERFAMILY SSF47384 215 296 2.94E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 Gene3D G3DSA:3.30.565.10 301 453 2.4E-34 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 PRINTS PR00344 Bacterial sensor protein C-terminal signature 416 434 8.4E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 PRINTS PR00344 Bacterial sensor protein C-terminal signature 440 453 8.4E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 PRINTS PR00344 Bacterial sensor protein C-terminal signature 383 397 8.4E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 PRINTS PR00344 Bacterial sensor protein C-terminal signature 401 411 8.4E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 SMART SM00387 347 455 6.1E-24 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 Gene3D G3DSA:1.10.287.130 222 294 1.9E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 PANTHER PTHR24423 172 453 2.0E-59 T 21-04-2016 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 PANTHER PTHR24423 3 9 2.0E-59 T 21-04-2016 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 Pfam PF00512 His Kinase A (phospho-acceptor) domain 233 295 9.2E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 SUPERFAMILY SSF158472 181 229 6.41E-8 T 21-04-2016 SPH21_RS16715 7d9deae392fdfdb5a3b76c879a4d6704 455 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 352 453 8.4E-19 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05770 c3dd86275472cd3dd369d4b89a970410 115 Gene3D G3DSA:1.20.1440.60 1 115 1.6E-36 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS05770 c3dd86275472cd3dd369d4b89a970410 115 PANTHER PTHR38471 1 108 2.7E-33 T 21-04-2016 SPH21_RS05770 c3dd86275472cd3dd369d4b89a970410 115 TIGRFAM TIGR02436 TIGR02436: four helix bundle protein 10 115 3.0E-38 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS05770 c3dd86275472cd3dd369d4b89a970410 115 Pfam PF05635 23S rRNA-intervening sequence protein 6 109 6.8E-38 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS05770 c3dd86275472cd3dd369d4b89a970410 115 PANTHER PTHR38471:SF2 1 108 2.7E-33 T 21-04-2016 SPH21_RS05770 c3dd86275472cd3dd369d4b89a970410 115 SUPERFAMILY SSF158446 3 114 2.35E-36 T 21-04-2016 SPH21_RS13040 5e83a50e192e21e6349593b43e3441ea 558 Pfam PF14322 Starch-binding associating with outer membrane 22 215 3.6E-27 T 21-04-2016 SPH21_RS13040 5e83a50e192e21e6349593b43e3441ea 558 Gene3D G3DSA:1.25.40.10 312 326 1.2E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13040 5e83a50e192e21e6349593b43e3441ea 558 Gene3D G3DSA:1.25.40.10 397 496 1.2E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13040 5e83a50e192e21e6349593b43e3441ea 558 Gene3D G3DSA:1.25.40.10 194 279 1.2E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13040 5e83a50e192e21e6349593b43e3441ea 558 Pfam PF07980 SusD family 264 557 6.5E-45 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13040 5e83a50e192e21e6349593b43e3441ea 558 SUPERFAMILY SSF48452 16 557 1.39E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 PIRSF PIRSF005901 1 186 2.6E-65 T 21-04-2016 IPR020599 Translation elongation factor P/YeiP UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 Gene3D G3DSA:2.40.50.140 128 185 3.7E-30 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 Hamap MF_00141 Elongation factor P [efp]. 1 185 43.776 T 21-04-2016 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 Pfam PF08207 Elongation factor P (EF-P) KOW-like domain 3 60 1.8E-18 T 21-04-2016 IPR013185 Translation elongation factor, KOW-like UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 Pfam PF01132 Elongation factor P (EF-P) OB domain 69 121 3.7E-19 T 21-04-2016 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 PANTHER PTHR30053 1 186 8.3E-77 T 21-04-2016 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 TIGRFAM TIGR00038 efp: translation elongation factor P 3 185 3.6E-69 T 21-04-2016 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 Gene3D G3DSA:2.40.50.140 64 127 4.0E-21 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 SMART SM01185 67 121 3.2E-21 T 21-04-2016 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 Gene3D G3DSA:2.30.30.30 3 63 4.8E-19 T 21-04-2016 IPR014722 Ribosomal protein L2 domain 2 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 SUPERFAMILY SSF50249 65 129 3.47E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 Pfam PF09285 Elongation factor P, C-terminal 129 184 1.8E-28 T 21-04-2016 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 ProSitePatterns PS01275 Elongation factor P signature. 150 169 - T 21-04-2016 IPR013852 Translation elongation factor P/YeiP, conserved site UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 SUPERFAMILY SSF50249 128 185 3.26E-19 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 SMART SM00841 129 184 1.8E-33 T 21-04-2016 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 UniPathway: UPA00345 SPH21_RS07640 deadbb53a64f503f50489898606b51a3 186 SUPERFAMILY SSF50104 1 63 1.2E-15 T 21-04-2016 IPR008991 Translation protein SH3-like domain SPH21_RS06345 1472d1b687818d2c19ee6746a402f1f1 265 SUPERFAMILY SSF46689 216 254 2.42E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06345 1472d1b687818d2c19ee6746a402f1f1 265 PANTHER PTHR11019 165 260 2.8E-19 T 21-04-2016 SPH21_RS06345 1472d1b687818d2c19ee6746a402f1f1 265 Gene3D G3DSA:1.10.10.60 168 201 2.4E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06345 1472d1b687818d2c19ee6746a402f1f1 265 Gene3D G3DSA:1.10.10.60 216 253 2.4E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06345 1472d1b687818d2c19ee6746a402f1f1 265 Pfam PF12833 Helix-turn-helix domain 177 253 2.3E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS06345 1472d1b687818d2c19ee6746a402f1f1 265 PANTHER PTHR11019:SF126 165 260 2.8E-19 T 21-04-2016 SPH21_RS06345 1472d1b687818d2c19ee6746a402f1f1 265 SMART SM00342 167 252 1.0E-13 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS18905 47d8965a0442cf5663acfaffca225b10 184 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport 80 154 1.1E-9 T 21-04-2016 IPR005031 Coenzyme Q-binding protein COQ10, START domain SPH21_RS18905 47d8965a0442cf5663acfaffca225b10 184 PANTHER PTHR33824:SF2 71 173 1.1E-23 T 21-04-2016 SPH21_RS18905 47d8965a0442cf5663acfaffca225b10 184 Pfam PF11127 Protein of unknown function (DUF2892) 11 66 1.2E-7 T 21-04-2016 IPR021309 Protein of unknown function DUF2892 SPH21_RS18905 47d8965a0442cf5663acfaffca225b10 184 SUPERFAMILY SSF55961 76 177 1.27E-16 T 21-04-2016 SPH21_RS18905 47d8965a0442cf5663acfaffca225b10 184 PANTHER PTHR33824 71 173 1.1E-23 T 21-04-2016 SPH21_RS26160 e9fc656f042ce3712e538feda020e1c1 470 TIGRFAM TIGR03023 WcaJ_sugtrans: undecaprenyl-phosphate glucose phosphotransferase 17 470 1.3E-124 T 21-04-2016 IPR017473 Undecaprenyl-phosphate glucose phosphotransferase, WcaJ MetaCyc: PWY-6655|MetaCyc: PWY-6658 SPH21_RS26160 e9fc656f042ce3712e538feda020e1c1 470 Pfam PF13727 CoA-binding domain 62 235 7.3E-6 T 21-04-2016 SPH21_RS26160 e9fc656f042ce3712e538feda020e1c1 470 Pfam PF02397 Bacterial sugar transferase 274 463 1.8E-57 T 21-04-2016 IPR003362 Bacterial sugar transferase SPH21_RS26160 e9fc656f042ce3712e538feda020e1c1 470 TIGRFAM TIGR03025 EPS_sugtrans: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase 16 470 1.9E-117 T 21-04-2016 IPR017475 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase SPH21_RS26160 e9fc656f042ce3712e538feda020e1c1 470 PANTHER PTHR30576 17 470 7.3E-117 T 21-04-2016 SPH21_RS26160 e9fc656f042ce3712e538feda020e1c1 470 PANTHER PTHR30576:SF0 17 470 7.3E-117 T 21-04-2016 SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 Pfam PF13354 Beta-lactamase enzyme family 562 779 8.6E-48 T 21-04-2016 SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 PANTHER PTHR22935:SF68 39 462 8.5E-99 T 21-04-2016 SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 SUPERFAMILY SSF56601 539 804 3.99E-43 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 PANTHER PTHR22935 39 462 8.5E-99 T 21-04-2016 SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 Pfam PF11954 Domain of unknown function (DUF3471) 431 511 4.6E-13 T 21-04-2016 IPR021860 Peptidase S12, Pab87-related, C-terminal SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 Gene3D G3DSA:3.40.710.10 539 804 2.8E-56 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 Gene3D G3DSA:3.40.710.10 51 394 6.3E-82 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 SUPERFAMILY SSF56601 38 392 9.7E-81 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS22425 9d0c8f291eb19dd594e2f5da19ba3ad4 812 Pfam PF00144 Beta-lactamase 42 378 2.6E-61 T 21-04-2016 IPR001466 Beta-lactamase-related SPH21_RS14305 2187e5297ae1b1cfc3d2924f9b272ab5 156 PANTHER PTHR11803 11 156 9.0E-36 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS14305 2187e5297ae1b1cfc3d2924f9b272ab5 156 Gene3D G3DSA:3.30.1330.40 7 155 1.0E-53 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS14305 2187e5297ae1b1cfc3d2924f9b272ab5 156 SUPERFAMILY SSF55298 5 155 2.2E-47 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS14305 2187e5297ae1b1cfc3d2924f9b272ab5 156 Pfam PF14588 YjgF/chorismate_mutase-like, putative endoribonuclease 11 152 1.2E-24 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS14305 2187e5297ae1b1cfc3d2924f9b272ab5 156 PANTHER PTHR11803:SF2 11 156 9.0E-36 T 21-04-2016 SPH21_RS02320 6f0ed84f3e3cce4ec3a79a2f69c0d64a 1122 SUPERFAMILY SSF48208 262 707 1.36E-36 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02320 6f0ed84f3e3cce4ec3a79a2f69c0d64a 1122 Pfam PF04685 Glycosyl-hydrolase family 116, catalytic region 405 527 2.2E-7 T 21-04-2016 IPR006775 Glycosyl-hydrolase family 116, catalytic region GO:0004553 KEGG: 00511+3.2.1.45|KEGG: 00600+3.2.1.45 SPH21_RS02320 6f0ed84f3e3cce4ec3a79a2f69c0d64a 1122 Pfam PF14614 Domain of unknown function (DUF4450) 75 268 8.5E-51 T 21-04-2016 IPR028028 Protein of unknown function DUF4450 SPH21_RS02320 6f0ed84f3e3cce4ec3a79a2f69c0d64a 1122 Gene3D G3DSA:1.50.10.10 415 526 3.4E-5 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 PANTHER PTHR30126 1 284 3.2E-76 T 21-04-2016 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 Gene3D G3DSA:1.10.10.10 1 81 9.5E-27 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.3E-6 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.3E-6 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.3E-6 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 SUPERFAMILY SSF53850 88 290 1.12E-33 T 21-04-2016 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 SUPERFAMILY SSF46785 1 110 1.47E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 Gene3D G3DSA:3.40.190.10 82 190 6.6E-21 T 21-04-2016 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 PANTHER PTHR30126:SF31 1 284 3.2E-76 T 21-04-2016 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 Gene3D G3DSA:3.40.190.10 191 257 2.8E-10 T 21-04-2016 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 6.7E-20 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS21510 4982cb50fee246c3314b621ca8608565 298 Pfam PF03466 LysR substrate binding domain 88 287 6.8E-37 T 21-04-2016 IPR005119 LysR, substrate-binding SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 206 236 1.9E-14 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 Gene3D G3DSA:2.40.170.20 897 946 6.8E-22 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 Gene3D G3DSA:2.40.170.20 343 439 6.8E-22 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 Gene3D G3DSA:2.40.170.20 479 844 6.8E-22 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 SUPERFAMILY SSF56935 908 952 5.13E-65 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 SUPERFAMILY SSF56935 103 253 5.13E-65 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 SUPERFAMILY SSF56935 994 1043 5.13E-65 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 SUPERFAMILY SSF56935 335 423 5.13E-65 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 SUPERFAMILY SSF56935 472 844 5.13E-65 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 Gene3D G3DSA:2.170.130.10 158 240 1.4E-10 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 Pfam PF07715 TonB-dependent Receptor Plug Domain 117 230 2.7E-12 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 SUPERFAMILY SSF49464 23 105 2.22E-9 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 Pfam PF13715 CarboxypepD_reg-like domain 25 107 3.3E-10 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 PANTHER PTHR11532 561 1073 2.2E-118 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 PANTHER PTHR11532 1 389 2.2E-118 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 PANTHER PTHR11532 472 523 2.2E-118 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 PANTHER PTHR11532:SF57 561 1073 2.2E-118 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 PANTHER PTHR11532:SF57 1 389 2.2E-118 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 PANTHER PTHR11532:SF57 472 523 2.2E-118 T 21-04-2016 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 23 1075 2.1E-149 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS24250 4d5be987ff004ca3a19c920f8024749c 1075 Gene3D G3DSA:2.60.40.1120 24 110 1.4E-6 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11430 6e4304340eb62ce1f1b584d8a6f67349 298 Gene3D G3DSA:3.20.20.150 37 294 9.6E-25 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS11430 6e4304340eb62ce1f1b584d8a6f67349 298 SUPERFAMILY SSF51658 35 274 9.95E-27 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS11430 6e4304340eb62ce1f1b584d8a6f67349 298 Pfam PF01261 Xylose isomerase-like TIM barrel 54 259 2.6E-16 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 Gene3D G3DSA:1.10.166.10 2 67 1.5E-23 T 21-04-2016 IPR023180 Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1 KEGG: 00300+2.3.1.117|UniPathway: UPA00034 SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 Gene3D G3DSA:2.160.10.10 86 250 1.1E-50 T 21-04-2016 SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 PANTHER PTHR19136 6 266 1.8E-74 T 21-04-2016 SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 SUPERFAMILY SSF51161 8 249 6.42E-60 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 166 201 3.7E-13 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 PANTHER PTHR19136:SF52 6 266 1.8E-74 T 21-04-2016 IPR005664 Tetrahydrodipicolinate N-succinyltransferase, transferase hexapeptide repeat family GO:0008666|GO:0009089 KEGG: 00300+2.3.1.117|UniPathway: UPA00034 SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 Pfam PF14805 Tetrahydrodipicolinate N-succinyltransferase N-terminal 4 66 1.9E-20 T 21-04-2016 IPR023180 Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1 KEGG: 00300+2.3.1.117|UniPathway: UPA00034 SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 124 157 0.001 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS12015 b44fcaabc0bd07a5b7b006dbb5d5125f 272 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 125 153 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 613 722 4.8E-20 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 Pfam PF07696 7TMR-DISM extracellular 2 49 179 1.5E-21 T 21-04-2016 IPR011622 7TM-DISM receptor, extracellular domain, type 2 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 Gene3D G3DSA:3.30.565.10 576 721 1.3E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 SUPERFAMILY SSF55874 558 726 1.15E-39 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423 532 733 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423 463 495 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423 89 112 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423 430 446 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 SMART SM00387 610 724 2.0E-28 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423:SF497 532 733 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423:SF497 463 495 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423:SF497 89 112 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PANTHER PTHR24423:SF497 430 446 2.8E-66 T 21-04-2016 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PRINTS PR00344 Bacterial sensor protein C-terminal signature 708 721 8.6E-18 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PRINTS PR00344 Bacterial sensor protein C-terminal signature 653 667 8.6E-18 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PRINTS PR00344 Bacterial sensor protein C-terminal signature 684 702 8.6E-18 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 PRINTS PR00344 Bacterial sensor protein C-terminal signature 671 681 8.6E-18 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 Pfam PF07695 7TM diverse intracellular signalling 192 394 3.7E-47 T 21-04-2016 IPR011623 7TM-DISM receptor, extracellular domain, type 1 SPH21_RS10090 5ed00b51cb51dd2d9ca3dbc25b84e1c5 744 Pfam PF00512 His Kinase A (phospho-acceptor) domain 467 569 6.6E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 PANTHER PTHR23500:SF22 7 434 8.1E-162 T 21-04-2016 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 Gene3D G3DSA:1.20.1250.20 237 434 1.8E-23 T 21-04-2016 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 Gene3D G3DSA:1.20.1250.20 9 198 7.9E-28 T 21-04-2016 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 PRINTS PR00171 Sugar transporter signature 15 25 1.1E-21 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 PRINTS PR00171 Sugar transporter signature 358 370 1.1E-21 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 PRINTS PR00171 Sugar transporter signature 249 259 1.1E-21 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 PRINTS PR00171 Sugar transporter signature 335 356 1.1E-21 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 PRINTS PR00171 Sugar transporter signature 98 117 1.1E-21 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 ProSitePatterns PS00217 Sugar transport proteins signature 2. 103 128 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 ProSitePatterns PS00216 Sugar transport proteins signature 1. 293 310 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 Pfam PF00083 Sugar (and other) transporter 8 435 6.1E-111 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 5 432 8.7E-109 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 SUPERFAMILY SSF103473 4 434 3.27E-71 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS21225 475360a06abd2bd8edd1e160b262cdf4 438 PANTHER PTHR23500 7 434 8.1E-162 T 21-04-2016 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 Pfam PF00817 impB/mucB/samB family 9 156 1.9E-49 T 21-04-2016 IPR001126 UmuC domain GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 PANTHER PTHR11076 4 351 5.0E-136 T 21-04-2016 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 SUPERFAMILY SSF56672 4 236 1.78E-88 T 21-04-2016 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 Gene3D G3DSA:1.10.150.20 168 237 4.6E-22 T 21-04-2016 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 Pfam PF11799 impB/mucB/samB family C-terminal domain 238 344 8.8E-13 T 21-04-2016 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 Hamap MF_01113 DNA polymerase IV [dinB]. 3 353 38.273 T 21-04-2016 IPR022880 DNA polymerase IV GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 Gene3D G3DSA:3.30.1490.100 243 348 1.4E-25 T 21-04-2016 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 Pfam PF11798 IMS family HHH motif 168 199 2.5E-7 T 21-04-2016 IPR024728 DNA polymerase type-Y, HhH motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 SUPERFAMILY SSF100879 243 352 3.92E-23 T 21-04-2016 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS15925 d302062f77b913be8ff15ff427ba0f3a 354 Gene3D G3DSA:3.30.70.270 68 165 1.4E-33 T 21-04-2016 SPH21_RS14230 e3f6831dc9c7d9507ca790d8c7a39b6b 522 Gene3D G3DSA:1.25.40.10 364 459 2.1E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14230 e3f6831dc9c7d9507ca790d8c7a39b6b 522 Gene3D G3DSA:1.25.40.10 212 309 2.1E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14230 e3f6831dc9c7d9507ca790d8c7a39b6b 522 Pfam PF07980 SusD family 299 521 9.1E-46 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14230 e3f6831dc9c7d9507ca790d8c7a39b6b 522 Pfam PF14322 Starch-binding associating with outer membrane 85 231 9.5E-16 T 21-04-2016 SPH21_RS14230 e3f6831dc9c7d9507ca790d8c7a39b6b 522 SUPERFAMILY SSF48452 22 521 7.08E-117 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12300 bb5c80aebc5c3b59bb4eda0b0219243a 79 PANTHER PTHR37318 1 76 9.1E-23 T 21-04-2016 SPH21_RS12300 bb5c80aebc5c3b59bb4eda0b0219243a 79 Gene3D G3DSA:1.10.10.10 1 77 2.7E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12300 bb5c80aebc5c3b59bb4eda0b0219243a 79 Pfam PF13601 Winged helix DNA-binding domain 1 75 1.0E-26 T 21-04-2016 IPR027395 Winged helix DNA-binding domain SPH21_RS12300 bb5c80aebc5c3b59bb4eda0b0219243a 79 SUPERFAMILY SSF46785 4 76 2.78E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 SMART SM00248 221 252 710.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 SMART SM00248 262 291 400.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 SMART SM00248 331 370 1100.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 SMART SM00248 188 217 2.4E-7 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 SMART SM00248 115 145 73.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 SMART SM00248 149 184 820.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 SUPERFAMILY SSF48403 105 387 2.62E-36 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 Pfam PF12796 Ankyrin repeats (3 copies) 121 219 6.8E-13 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 PANTHER PTHR24198 109 397 2.8E-31 T 21-04-2016 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 PANTHER PTHR24198 33 66 2.8E-31 T 21-04-2016 SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 Gene3D G3DSA:1.25.40.20 106 397 3.2E-39 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12110 c03f8312c4b0b0c0d526308df0b2ac1c 399 Gene3D G3DSA:1.25.40.20 4 63 3.2E-39 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS14025 1978973bbb8f89d2c79159c5478535cb 106 SUPERFAMILY SSF51182 4 105 1.15E-20 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS14025 1978973bbb8f89d2c79159c5478535cb 106 Pfam PF07883 Cupin domain 32 94 1.1E-10 T 21-04-2016 IPR013096 Cupin 2, conserved barrel SPH21_RS14025 1978973bbb8f89d2c79159c5478535cb 106 PANTHER PTHR40112 1 106 8.8E-22 T 21-04-2016 SPH21_RS14025 1978973bbb8f89d2c79159c5478535cb 106 PIRSF PIRSF029883 1 106 4.6E-36 T 21-04-2016 IPR025499 Pectin degradation protein KdgF UniPathway: UPA00545 SPH21_RS14025 1978973bbb8f89d2c79159c5478535cb 106 PANTHER PTHR40112:SF1 1 106 8.8E-22 T 21-04-2016 SPH21_RS14025 1978973bbb8f89d2c79159c5478535cb 106 Gene3D G3DSA:2.60.120.10 5 106 1.7E-28 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS00990 84f1f605e3132c60e0c5eb7375800468 185 PANTHER PTHR30543 1 145 2.6E-15 T 21-04-2016 SPH21_RS00990 84f1f605e3132c60e0c5eb7375800468 185 Gene3D G3DSA:3.40.50.360 1 161 2.8E-32 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS00990 84f1f605e3132c60e0c5eb7375800468 185 SUPERFAMILY SSF52218 1 158 3.11E-25 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS00990 84f1f605e3132c60e0c5eb7375800468 185 PANTHER PTHR30543:SF1 1 145 2.6E-15 T 21-04-2016 SPH21_RS00990 84f1f605e3132c60e0c5eb7375800468 185 Pfam PF03358 NADPH-dependent FMN reductase 1 143 6.4E-18 T 21-04-2016 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SPH21_RS08505 9e2ce914276b3f8b356e1318a01b2410 96 SUPERFAMILY SSF54189 1 94 2.73E-30 T 21-04-2016 IPR012678 Ribosomal protein L23/L15e core domain GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08505 9e2ce914276b3f8b356e1318a01b2410 96 Pfam PF00276 Ribosomal protein L23 2 92 1.0E-32 T 21-04-2016 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08505 9e2ce914276b3f8b356e1318a01b2410 96 Gene3D G3DSA:3.30.70.330 1 95 1.6E-34 T 21-04-2016 IPR012677 Nucleotide-binding alpha-beta plait domain GO:0000166 SPH21_RS08505 9e2ce914276b3f8b356e1318a01b2410 96 Hamap MF_01369_B 50S ribosomal protein L23 [rplW]. 1 95 22.737 T 21-04-2016 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08505 9e2ce914276b3f8b356e1318a01b2410 96 PANTHER PTHR11620 1 58 1.7E-27 T 21-04-2016 SPH21_RS08505 9e2ce914276b3f8b356e1318a01b2410 96 PANTHER PTHR11620 76 96 1.7E-27 T 21-04-2016 SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 PANTHER PTHR11135 9 314 9.2E-103 T 21-04-2016 SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 Gene3D G3DSA:3.80.30.20 30 240 3.0E-24 T 21-04-2016 IPR023404 Radical SAM, alpha/beta horseshoe SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 SMART SM00729 29 259 1.2E-26 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 Pfam PF04055 Radical SAM superfamily 49 213 2.9E-9 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 SUPERFAMILY SSF102114 23 275 7.65E-36 T 21-04-2016 SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 Pfam PF16199 Radical_SAM C-terminal domain 220 303 3.5E-19 T 21-04-2016 IPR032432 Radical SAM, C-terminal extension SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 PANTHER PTHR11135:SF1 9 314 9.2E-103 T 21-04-2016 IPR005911 Protein YhcC-like GO:0051536 SPH21_RS20400 c53cabd2024ec17b2b1edf5d3e6bee4b 323 TIGRFAM TIGR01212 TIGR01212: radical SAM protein, TIGR01212 family 12 313 1.8E-87 T 21-04-2016 IPR005911 Protein YhcC-like GO:0051536 SPH21_RS20910 cceddc2f2e78b7baf6262b9c730a0321 247 Pfam PF12120 Rifampin ADP-ribosyl transferase 125 223 2.4E-50 T 21-04-2016 IPR021975 DNA/RNA tunnel of bacterial DNA dependent RNA polymerase SPH21_RS20910 cceddc2f2e78b7baf6262b9c730a0321 247 SUPERFAMILY SSF48452 15 115 8.22E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20910 cceddc2f2e78b7baf6262b9c730a0321 247 Gene3D G3DSA:1.25.40.10 14 111 3.3E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 ProSitePatterns PS00798 Aldo/keto reductase family signature 1. 39 56 - T 21-04-2016 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 Pfam PF00248 Aldo/keto reductase family 18 257 1.2E-43 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 Gene3D G3DSA:3.20.20.100 3 266 9.6E-96 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 PANTHER PTHR11732:SF236 1 283 1.5E-137 T 21-04-2016 SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 PANTHER PTHR11732 1 283 1.5E-137 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 SUPERFAMILY SSF51430 4 264 2.23E-85 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 PRINTS PR00069 Aldo-keto reductase signature 120 137 4.7E-43 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 PRINTS PR00069 Aldo-keto reductase signature 154 183 4.7E-43 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 PRINTS PR00069 Aldo-keto reductase signature 91 109 4.7E-43 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 PRINTS PR00069 Aldo-keto reductase signature 35 59 4.7E-43 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS00630 0788a7bf46f0cf3766b360bb5724808d 283 PRINTS PR00069 Aldo-keto reductase signature 193 217 4.7E-43 T 21-04-2016 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PIRSF PIRSF500210 1 334 2.4E-127 T 21-04-2016 IPR028343 Fructose-1,6-bisphosphatase KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 Pfam PF00316 Fructose-1-6-bisphosphatase, N-terminal domain 6 195 4.4E-74 T 21-04-2016 IPR033391 Fructose-1-6-bisphosphatase class I, N-terminal KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PIRSF PIRSF000904 1 335 9.0E-126 T 21-04-2016 IPR000146 Fructose-1,6-bisphosphatase class 1 GO:0005975|GO:0042132|GO:0042578 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|Reactome: REACT_474|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PRINTS PR00115 Fructose-1,6-bisphosphatase signature 181 204 8.3E-73 T 21-04-2016 IPR028343 Fructose-1,6-bisphosphatase KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PRINTS PR00115 Fructose-1,6-bisphosphatase signature 30 57 8.3E-73 T 21-04-2016 IPR028343 Fructose-1,6-bisphosphatase KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PRINTS PR00115 Fructose-1,6-bisphosphatase signature 207 234 8.3E-73 T 21-04-2016 IPR028343 Fructose-1,6-bisphosphatase KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PRINTS PR00115 Fructose-1,6-bisphosphatase signature 306 331 8.3E-73 T 21-04-2016 IPR028343 Fructose-1,6-bisphosphatase KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PRINTS PR00115 Fructose-1,6-bisphosphatase signature 67 93 8.3E-73 T 21-04-2016 IPR028343 Fructose-1,6-bisphosphatase KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PRINTS PR00115 Fructose-1,6-bisphosphatase signature 150 173 8.3E-73 T 21-04-2016 IPR028343 Fructose-1,6-bisphosphatase KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 ProSitePatterns PS00124 Fructose-1-6-bisphosphatase active site. 272 284 - T 21-04-2016 IPR020548 Fructose-1,6-bisphosphatase, active site GO:0005975|GO:0042578 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|Reactome: REACT_474 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 Hamap MF_01855 Fructose-1,6-bisphosphatase class 1 [fbp]. 5 332 42.319 T 21-04-2016 IPR000146 Fructose-1,6-bisphosphatase class 1 GO:0005975|GO:0042132|GO:0042578 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|Reactome: REACT_474|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 Gene3D G3DSA:3.40.190.80 198 331 2.4E-58 T 21-04-2016 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 PANTHER PTHR11556 2 330 1.2E-183 T 21-04-2016 IPR000146 Fructose-1,6-bisphosphatase class 1 GO:0005975|GO:0042132|GO:0042578 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484|Reactome: REACT_474|UniPathway: UPA00138 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 SUPERFAMILY SSF56655 3 330 9.69E-115 T 21-04-2016 SPH21_RS15650 9a2ac76154c52e9a8f1a81078888fddd 347 Gene3D G3DSA:3.30.540.10 5 197 6.1E-78 T 21-04-2016 SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 Gene3D G3DSA:3.60.15.10 3 238 7.6E-57 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 PANTHER PTHR11935:SF9 1 275 1.2E-68 T 21-04-2016 SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 Gene3D G3DSA:3.40.250.10 360 426 8.6E-14 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 SMART SM00849 12 184 2.2E-27 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 SMART SM00450 351 443 0.0069 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 Pfam PF00581 Rhodanese-like domain 364 434 9.4E-5 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 SUPERFAMILY SSF56281 1 241 6.86E-49 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 Pfam PF00753 Metallo-beta-lactamase superfamily 10 184 8.4E-13 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 SUPERFAMILY SSF52821 225 335 1.83E-9 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 Gene3D G3DSA:3.40.250.10 264 304 7.0E-12 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 SUPERFAMILY SSF52821 349 432 9.04E-13 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS22915 a57d41c910fd739990dbadf03bdf094d 445 PANTHER PTHR11935 1 275 1.2E-68 T 21-04-2016 SPH21_RS22180 a50edc50012fcb6f3176218387fc80a8 362 PANTHER PTHR11019:SF61 217 348 1.8E-17 T 21-04-2016 SPH21_RS22180 a50edc50012fcb6f3176218387fc80a8 362 SUPERFAMILY SSF46689 305 351 3.27E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22180 a50edc50012fcb6f3176218387fc80a8 362 SMART SM00342 269 352 3.4E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22180 a50edc50012fcb6f3176218387fc80a8 362 PANTHER PTHR11019 217 348 1.8E-17 T 21-04-2016 SPH21_RS22180 a50edc50012fcb6f3176218387fc80a8 362 Gene3D G3DSA:1.10.10.60 253 305 1.0E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22180 a50edc50012fcb6f3176218387fc80a8 362 Pfam PF12833 Helix-turn-helix domain 275 349 1.0E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22180 a50edc50012fcb6f3176218387fc80a8 362 Gene3D G3DSA:1.10.10.60 306 350 1.7E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13475 ed62074f3e3d2383d19b7b52617b636e 386 Pfam PF10633 NPCBM-associated, NEW3 domain of alpha-galactosidase 266 341 5.0E-15 T 21-04-2016 IPR018905 Alpha-galactosidase, NEW3 domain SPH21_RS13475 ed62074f3e3d2383d19b7b52617b636e 386 PANTHER PTHR39198:SF1 1 386 3.7E-57 T 21-04-2016 SPH21_RS13475 ed62074f3e3d2383d19b7b52617b636e 386 Gene3D G3DSA:2.60.40.10 257 355 2.5E-15 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS13475 ed62074f3e3d2383d19b7b52617b636e 386 PANTHER PTHR39198 1 386 3.7E-57 T 21-04-2016 SPH21_RS05255 e4a8221afbfda30c69fda90dc56f7368 421 Pfam PF00149 Calcineurin-like phosphoesterase 174 354 3.6E-14 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS05255 e4a8221afbfda30c69fda90dc56f7368 421 PANTHER PTHR31302:SF6 115 418 4.4E-58 T 21-04-2016 SPH21_RS05255 e4a8221afbfda30c69fda90dc56f7368 421 SUPERFAMILY SSF56300 170 416 1.27E-31 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS05255 e4a8221afbfda30c69fda90dc56f7368 421 Gene3D G3DSA:3.60.21.10 173 369 2.7E-23 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS05255 e4a8221afbfda30c69fda90dc56f7368 421 PANTHER PTHR31302 115 418 4.4E-58 T 21-04-2016 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 SUPERFAMILY SSF69065 17 160 1.1E-38 T 21-04-2016 IPR000999 Ribonuclease III domain GO:0003723|GO:0004525|GO:0006396 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 SMART SM00358 175 241 7.8E-14 T 21-04-2016 IPR014720 Double-stranded RNA-binding domain SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 Pfam PF00035 Double-stranded RNA binding motif 176 240 1.8E-12 T 21-04-2016 IPR014720 Double-stranded RNA-binding domain SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 Pfam PF14622 Ribonuclease-III-like 34 161 3.5E-27 T 21-04-2016 IPR000999 Ribonuclease III domain GO:0003723|GO:0004525|GO:0006396 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 Gene3D G3DSA:3.30.160.20 173 241 2.4E-14 T 21-04-2016 IPR014720 Double-stranded RNA-binding domain SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 SMART SM00535 33 168 1.5E-33 T 21-04-2016 IPR000999 Ribonuclease III domain GO:0003723|GO:0004525|GO:0006396 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 PANTHER PTHR11207 18 243 3.4E-46 T 21-04-2016 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 SUPERFAMILY SSF54768 128 242 2.2E-18 T 21-04-2016 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 Gene3D G3DSA:1.10.1520.10 18 159 4.6E-37 T 21-04-2016 IPR000999 Ribonuclease III domain GO:0003723|GO:0004525|GO:0006396 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 TIGRFAM TIGR02191 RNaseIII: ribonuclease III 25 240 1.0E-55 T 21-04-2016 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 ProSitePatterns PS00517 Ribonuclease III family signature. 57 65 - T 21-04-2016 IPR000999 Ribonuclease III domain GO:0003723|GO:0004525|GO:0006396 SPH21_RS06685 6c673c74a1db28009d8728f53a8ac2a2 243 Hamap MF_00104 Ribonuclease 3 [rnc]. 21 237 24.59 T 21-04-2016 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 Pfam PF00072 Response regulator receiver domain 3 113 2.9E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 SMART SM00448 1 112 7.4E-40 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 Gene3D G3DSA:3.40.50.2300 1 124 2.3E-40 T 21-04-2016 SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 PANTHER PTHR26402:SF578 1 226 5.0E-89 T 21-04-2016 SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 SUPERFAMILY SSF52172 1 169 3.56E-42 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 SMART SM00862 148 223 2.4E-21 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 Gene3D G3DSA:1.10.10.10 126 225 1.4E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 Pfam PF00486 Transcriptional regulatory protein, C terminal 150 223 7.6E-23 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS16720 c6bf783be870b9dad87d05d5a5d10963 226 PANTHER PTHR26402 1 226 5.0E-89 T 21-04-2016 SPH21_RS09060 c9765885796bb1a6257e2f2b2ca24f07 242 PANTHER PTHR30336 7 241 2.8E-35 T 21-04-2016 SPH21_RS09060 c9765885796bb1a6257e2f2b2ca24f07 242 Pfam PF02698 DUF218 domain 72 232 6.6E-22 T 21-04-2016 IPR003848 Domain of unknown function DUF218 SPH21_RS09060 c9765885796bb1a6257e2f2b2ca24f07 242 Gene3D G3DSA:3.40.50.620 68 194 2.3E-9 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS09060 c9765885796bb1a6257e2f2b2ca24f07 242 PANTHER PTHR30336:SF1 7 241 2.8E-35 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 970 1091 4.0E-19 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF12833 Helix-turn-helix domain 1303 1381 5.6E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SUPERFAMILY SSF46689 1333 1384 3.23E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF00072 Response regulator receiver domain 1138 1245 2.0E-23 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:1.10.287.130 847 907 1.6E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:3.30.565.10 908 1091 6.8E-39 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SMART SM00387 968 1092 6.7E-31 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SUPERFAMILY SSF55874 910 1090 1.83E-36 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SUPERFAMILY SSF47384 846 922 1.1E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423:SF487 422 481 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423:SF487 251 270 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423:SF487 9 107 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423:SF487 799 1289 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SMART SM00342 1297 1381 5.8E-23 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:2.120.10.30 36 119 8.6E-5 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:2.120.10.30 335 448 3.5E-10 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:2.120.10.30 152 200 8.6E-5 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:2.120.10.30 470 541 3.7E-6 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:2.120.10.30 569 674 1.2E-4 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1047 1065 3.5E-8 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1030 1040 3.5E-8 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1012 1026 3.5E-8 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:1.10.10.60 1334 1381 8.6E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:2.120.10.30 238 304 2.3E-7 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07494 Two component regulator propeller 420 443 9.4E-6 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07494 Two component regulator propeller 37 59 0.0041 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07494 Two component regulator propeller 516 538 3.0E-6 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07494 Two component regulator propeller 468 491 1.5E-5 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07494 Two component regulator propeller 82 105 4.2E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07494 Two component regulator propeller 280 303 1.8E-5 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07494 Two component regulator propeller 325 347 7.8E-4 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SUPERFAMILY SSF63829 239 445 3.49E-13 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SMART SM00388 856 921 1.2E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SUPERFAMILY SSF63829 38 205 7.19E-10 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:1.10.10.60 1280 1333 8.4E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423 422 481 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423 251 270 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423 9 107 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 PANTHER PTHR24423 799 1289 8.1E-116 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF07495 Y_Y_Y domain 740 801 1.2E-15 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Gene3D G3DSA:3.40.50.2300 1132 1262 2.2E-36 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 Pfam PF00512 His Kinase A (phospho-acceptor) domain 857 921 3.7E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SUPERFAMILY SSF52172 1138 1268 2.56E-33 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SUPERFAMILY SSF63829 425 657 2.42E-13 T 21-04-2016 SPH21_RS14270 c3f70becf74ed13494d1aa1beb1c6336 1394 SMART SM00448 1136 1248 1.5E-32 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 PANTHER PTHR20852:SF35 1 452 4.7E-210 T 21-04-2016 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 Gene3D G3DSA:3.30.590.10 115 439 5.4E-98 T 21-04-2016 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 Reactome: REACT_13 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 Gene3D G3DSA:3.10.20.70 3 110 1.5E-5 T 21-04-2016 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 Pfam PF00120 Glutamine synthetase, catalytic domain 113 448 2.7E-99 T 21-04-2016 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 SUPERFAMILY SSF55931 113 450 4.61E-103 T 21-04-2016 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 PANTHER PTHR20852 1 452 4.7E-210 T 21-04-2016 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 SMART SM01230 112 368 1.2E-96 T 21-04-2016 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS03305 9e4918ecde21cfe5c795b6e603e81a65 452 SUPERFAMILY SSF54368 2 109 5.23E-9 T 21-04-2016 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 SUPERFAMILY SSF49464 53 134 5.76E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Gene3D G3DSA:2.170.130.10 140 252 2.6E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532 824 1023 1.4E-215 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532 585 807 1.4E-215 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532 50 442 1.4E-215 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532 521 548 1.4E-215 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 53 1025 2.8E-222 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Pfam PF13715 CarboxypepD_reg-like domain 55 136 1.2E-18 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Pfam PF07715 TonB-dependent Receptor Plug Domain 145 251 3.6E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 SUPERFAMILY SSF56935 868 1025 2.61E-85 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 SUPERFAMILY SSF56935 132 275 2.61E-85 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 SUPERFAMILY SSF56935 314 403 2.61E-85 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 SUPERFAMILY SSF56935 445 799 2.61E-85 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 227 257 9.0E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Gene3D G3DSA:2.60.40.1120 55 139 1.7E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Gene3D G3DSA:2.40.170.20 877 1025 1.8E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Gene3D G3DSA:2.40.170.20 440 823 1.8E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Gene3D G3DSA:2.40.170.20 253 271 1.8E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 Gene3D G3DSA:2.40.170.20 323 401 1.8E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532:SF57 824 1023 1.4E-215 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532:SF57 585 807 1.4E-215 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532:SF57 50 442 1.4E-215 T 21-04-2016 SPH21_RS25210 cba8b4e2e5dff5f7e01d8df7c3eca8ff 1025 PANTHER PTHR11532:SF57 521 548 1.4E-215 T 21-04-2016 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 25 145 4.2E-24 T 21-04-2016 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PANTHER PTHR22600:SF21 1 209 5.8E-161 T 21-04-2016 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PANTHER PTHR22600:SF21 226 525 5.8E-161 T 21-04-2016 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 149 497 2.8E-96 T 21-04-2016 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PANTHER PTHR22600 1 209 5.8E-161 T 21-04-2016 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PANTHER PTHR22600 226 525 5.8E-161 T 21-04-2016 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 Gene3D G3DSA:3.30.379.10 24 146 2.0E-29 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 SUPERFAMILY SSF55545 12 148 4.58E-26 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 479 496 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 172 193 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 243 260 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 313 326 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 109 129 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 143 160 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 291 309 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PRINTS PR00738 Glycosyl hydrolase family 20 signature 461 477 8.9E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 Gene3D G3DSA:3.20.20.80 147 526 3.1E-116 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 PIRSF PIRSF001093 24 528 3.0E-78 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03255 71a215947c628adaa56cd8a66e13aeee 528 SUPERFAMILY SSF51445 149 508 9.06E-110 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 PANTHER PTHR11851 27 121 2.1E-145 T 21-04-2016 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 PANTHER PTHR11851 166 948 2.1E-145 T 21-04-2016 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Pfam PF00675 Insulinase (Peptidase family M16) 156 218 1.3E-5 T 21-04-2016 IPR011765 Peptidase M16, N-terminal SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Pfam PF00675 Insulinase (Peptidase family M16) 60 131 4.1E-8 T 21-04-2016 IPR011765 Peptidase M16, N-terminal SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Pfam PF05193 Peptidase M16 inactive domain 755 869 4.3E-7 T 21-04-2016 IPR007863 Peptidase M16, C-terminal SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Pfam PF05193 Peptidase M16 inactive domain 263 427 3.5E-13 T 21-04-2016 IPR007863 Peptidase M16, C-terminal SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Gene3D G3DSA:3.30.830.10 763 948 1.1E-19 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Gene3D G3DSA:3.30.830.10 332 495 9.7E-18 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 SUPERFAMILY SSF63411 333 509 5.67E-22 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 ProSitePatterns PS00143 Insulinase family, zinc-binding region signature. 78 101 - T 21-04-2016 IPR001431 Peptidase M16, zinc-binding site GO:0004222|GO:0006508 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 SUPERFAMILY SSF63411 554 737 5.17E-17 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 PANTHER PTHR11851:SF136 27 121 2.1E-145 T 21-04-2016 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 PANTHER PTHR11851:SF136 166 948 2.1E-145 T 21-04-2016 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 SUPERFAMILY SSF63411 173 298 1.83E-39 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 SUPERFAMILY SSF63411 45 128 1.83E-39 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 SUPERFAMILY SSF63411 764 951 6.11E-26 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Gene3D G3DSA:3.30.830.10 155 312 9.5E-42 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Gene3D G3DSA:3.30.830.10 555 727 1.9E-15 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS07485 b81d022d63cb9f0834519dc40aa2fda5 975 Gene3D G3DSA:3.30.830.10 42 106 9.5E-42 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 Pfam PF05592 Bacterial alpha-L-rhamnosidase 362 878 7.4E-153 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 Gene3D G3DSA:2.60.120.260 161 245 2.0E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 Gene3D G3DSA:2.60.120.260 354 447 1.3E-11 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 SUPERFAMILY SSF48208 475 884 1.19E-41 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 PANTHER PTHR33307:SF5 1 925 6.8E-259 T 21-04-2016 SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 Gene3D G3DSA:2.60.40.10 45 130 1.6E-4 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 PIRSF PIRSF010631 1 925 9.2E-283 T 21-04-2016 IPR016007 Alpha-L-rhamnosidase SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 SUPERFAMILY SSF49785 167 248 9.57E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 PANTHER PTHR33307 1 925 6.8E-259 T 21-04-2016 SPH21_RS11465 8ad221bb2c775bdaa3a122046b12e40e 926 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 184 355 2.3E-57 T 21-04-2016 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SPH21_RS11895 2150309b03582ee6ed13f8dd4a21cca5 172 Hamap MF_00362 50S ribosomal protein L10 [rplJ]. 1 161 18.534 T 21-04-2016 IPR022973 Ribosomal protein L10 SPH21_RS11895 2150309b03582ee6ed13f8dd4a21cca5 172 PANTHER PTHR11560 1 171 5.7E-29 T 21-04-2016 SPH21_RS11895 2150309b03582ee6ed13f8dd4a21cca5 172 Pfam PF00466 Ribosomal protein L10 1 98 6.2E-20 T 21-04-2016 IPR001790 Ribosomal protein L10P GO:0005622|GO:0042254 SPH21_RS11895 2150309b03582ee6ed13f8dd4a21cca5 172 SUPERFAMILY SSF160369 1 170 1.44E-39 T 21-04-2016 SPH21_RS11895 2150309b03582ee6ed13f8dd4a21cca5 172 ProDom PD968187 BETA-DEFENSIN ANTIBIOTIC PRECURSOR ANTIMICROBIAL DEFENSIN BETA SIGNAL DEFENSIN BD-32 DEFB-32 75 144 0.009 T 21-04-2016 SPH21_RS11200 5f4b2a4be8c7e5fb23315bbf8883476f 401 SUPERFAMILY SSF51730 81 399 7.85E-86 T 21-04-2016 IPR029041 FAD-linked oxidoreductase-like SPH21_RS11200 5f4b2a4be8c7e5fb23315bbf8883476f 401 Pfam PF01619 Proline dehydrogenase 87 386 1.8E-86 T 21-04-2016 IPR002872 Proline dehydrogenase domain KEGG: 00330+1.5.5.2|MetaCyc: PWY-5737|MetaCyc: PWY-6922|UniPathway: UPA00261 SPH21_RS11200 5f4b2a4be8c7e5fb23315bbf8883476f 401 PANTHER PTHR13914 1 399 7.2E-134 T 21-04-2016 IPR015659 Proline oxidase family GO:0004657|GO:0006562 KEGG: 00330+1.5.5.2|MetaCyc: PWY-5737|MetaCyc: PWY-6922|UniPathway: UPA00261 SPH21_RS11200 5f4b2a4be8c7e5fb23315bbf8883476f 401 PANTHER PTHR13914:SF0 1 399 7.2E-134 T 21-04-2016 SPH21_RS11200 5f4b2a4be8c7e5fb23315bbf8883476f 401 Gene3D G3DSA:3.20.20.220 80 400 4.0E-97 T 21-04-2016 IPR029041 FAD-linked oxidoreductase-like SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PANTHER PTHR32472 1 460 1.8E-195 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 SUPERFAMILY SSF54211 258 272 8.72E-35 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 SUPERFAMILY SSF54211 306 461 8.72E-35 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 Gene3D G3DSA:3.40.50.300 68 280 2.6E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PANTHER PTHR32472:SF10 1 460 1.8E-195 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 TIGRFAM TIGR00416 sms: DNA repair protein RadA 1 455 9.1E-180 T 21-04-2016 IPR004504 DNA repair protein RadA GO:0003684|GO:0005524|GO:0006281 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 Pfam PF13481 AAA domain 73 225 8.6E-15 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 Pfam PF13541 Subunit ChlI of Mg-chelatase 347 433 7.6E-11 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 SMART SM00382 94 247 3.9E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 SUPERFAMILY SSF52540 72 296 2.13E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PRINTS PR01874 DNA repair protein radA signature 10 34 2.8E-90 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PRINTS PR01874 DNA repair protein radA signature 251 277 2.8E-90 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PRINTS PR01874 DNA repair protein radA signature 177 201 2.8E-90 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PRINTS PR01874 DNA repair protein radA signature 86 114 2.8E-90 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PRINTS PR01874 DNA repair protein radA signature 325 348 2.8E-90 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PRINTS PR01874 DNA repair protein radA signature 216 244 2.8E-90 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 PRINTS PR01874 DNA repair protein radA signature 126 143 2.8E-90 T 21-04-2016 SPH21_RS05535 a337a5e6f151ff9a1a80e392639f8ac4 461 Gene3D G3DSA:3.30.230.10 289 461 4.7E-32 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532 562 1080 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532 18 190 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532 449 492 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532 209 414 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Pfam PF13715 CarboxypepD_reg-like domain 26 108 7.4E-21 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 1082 5.0E-189 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Gene3D G3DSA:2.40.170.20 243 273 8.0E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Gene3D G3DSA:2.40.170.20 895 920 8.0E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Gene3D G3DSA:2.40.170.20 490 838 8.0E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Gene3D G3DSA:2.40.170.20 979 1082 8.0E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Gene3D G3DSA:2.40.170.20 369 444 8.0E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 SUPERFAMILY SSF49464 24 106 6.67E-19 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532:SF51 562 1080 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532:SF51 18 190 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532:SF51 449 492 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 PANTHER PTHR11532:SF51 209 414 9.7E-187 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Gene3D G3DSA:2.170.130.10 112 242 9.5E-25 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 SUPERFAMILY SSF56935 990 1082 2.88E-67 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 SUPERFAMILY SSF56935 896 931 2.88E-67 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 SUPERFAMILY SSF56935 106 270 2.88E-67 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 SUPERFAMILY SSF56935 370 438 2.88E-67 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 SUPERFAMILY SSF56935 484 826 2.88E-67 T 21-04-2016 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Gene3D G3DSA:2.60.40.1120 25 111 5.2E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 218 248 2.3E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS05435 9d767948c8ef1815226e8bdbd0960cdf 1082 Pfam PF07715 TonB-dependent Receptor Plug Domain 118 242 2.5E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01755 058f92b9bbb15897c124e99114286d07 354 SUPERFAMILY SSF50182 189 254 9.81E-14 T 21-04-2016 IPR010920 LSM domain SPH21_RS01755 058f92b9bbb15897c124e99114286d07 354 Gene3D G3DSA:2.30.30.60 204 253 3.5E-7 T 21-04-2016 SPH21_RS01755 058f92b9bbb15897c124e99114286d07 354 Pfam PF00924 Mechanosensitive ion channel 148 336 7.1E-28 T 21-04-2016 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SPH21_RS01755 058f92b9bbb15897c124e99114286d07 354 PANTHER PTHR30566:SF10 56 343 2.2E-74 T 21-04-2016 SPH21_RS01755 058f92b9bbb15897c124e99114286d07 354 PANTHER PTHR30566 56 343 2.2E-74 T 21-04-2016 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.40.47.10 928 1088 1.0E-42 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF47336 1663 1731 1.5E-7 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.20.20.70 90 201 1.4E-9 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF52151 1382 1480 1.91E-52 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF52151 1188 1317 1.91E-52 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF55048 1318 1380 3.92E-7 T 21-04-2016 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Pfam PF03060 Nitronate monooxygenase 83 207 1.4E-8 T 21-04-2016 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Pfam PF03060 Nitronate monooxygenase 290 551 3.3E-8 T 21-04-2016 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.20.20.70 291 617 7.6E-14 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF53901 649 767 1.14E-75 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF53901 810 1035 1.14E-75 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF51412 291 552 1.69E-13 T 21-04-2016 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 923 1039 7.1E-32 T 21-04-2016 IPR014031 Beta-ketoacyl synthase, C-terminal SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF51735 2080 2122 1.07E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF51735 2165 2325 1.07E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.40.47.10 651 927 4.5E-78 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 PANTHER PTHR11712:SF234 290 1518 0.0 T 21-04-2016 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.30.70.250 1318 1380 3.9E-7 T 21-04-2016 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:1.10.1200.10 1766 1851 1.8E-14 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:1.10.1200.10 1667 1736 1.7E-9 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF47336 1766 1855 2.24E-10 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SMART SM00825 Beta-ketoacyl synthase 651 1090 4.2E-112 T 21-04-2016 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 827 843 - T 21-04-2016 IPR018201 Beta-ketoacyl synthase, active site SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Pfam PF00550 Phosphopantetheine attachment site 1775 1825 2.3E-4 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 650 914 1.5E-77 T 21-04-2016 IPR014030 Beta-ketoacyl synthase, N-terminal SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Pfam PF08659 KR domain 2082 2301 1.2E-40 T 21-04-2016 IPR013968 Polyketide synthase, ketoreductase domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1192 1488 3.6E-29 T 21-04-2016 IPR020801 Polyketide synthase, acyl transferase domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Pfam PF00698 Acyl transferase domain 1191 1471 8.1E-27 T 21-04-2016 IPR014043 Acyl transferase SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.40.50.720 2081 2115 1.1E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.40.50.720 2160 2323 1.1E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 PANTHER PTHR11712 290 1518 0.0 T 21-04-2016 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2082 2303 1.3E-29 T 21-04-2016 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.40.366.10 1381 1485 2.4E-53 T 21-04-2016 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 Gene3D G3DSA:3.40.366.10 1184 1311 2.4E-53 T 21-04-2016 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SPH21_RS18350 2d6c6637e2dd3bc3f3e4d8dc4db4ed4c 2347 SUPERFAMILY SSF51412 18 205 2.75E-11 T 21-04-2016 SPH21_RS20620 aa1faae40fef14bc8b412f3a214b647d 801 SUPERFAMILY SSF48208 291 785 9.3E-85 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS20620 aa1faae40fef14bc8b412f3a214b647d 801 PANTHER PTHR31084 20 799 3.9E-304 T 21-04-2016 SPH21_RS20620 aa1faae40fef14bc8b412f3a214b647d 801 Gene3D G3DSA:2.70.98.50 29 418 1.0E-139 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS20620 aa1faae40fef14bc8b412f3a214b647d 801 PANTHER PTHR31084:SF0 20 799 3.9E-304 T 21-04-2016 SPH21_RS20620 aa1faae40fef14bc8b412f3a214b647d 801 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 30 277 7.3E-72 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS20620 aa1faae40fef14bc8b412f3a214b647d 801 PIRSF PIRSF007663 12 801 3.3E-275 T 21-04-2016 IPR016518 Alpha-L-fucosidase GO:0004560 KEGG: 00511+3.2.1.51 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 SMART SM00354 1 70 5.5E-19 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 Gene3D G3DSA:3.40.50.2300 53 172 1.3E-43 T 21-04-2016 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 SUPERFAMILY SSF53822 59 336 4.71E-65 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 Pfam PF00356 Bacterial regulatory proteins, lacI family 2 47 2.2E-11 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 Pfam PF13377 Periplasmic binding protein-like domain 169 336 1.8E-31 T 21-04-2016 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 PANTHER PTHR30146 1 338 1.5E-96 T 21-04-2016 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 Gene3D G3DSA:3.40.50.2300 173 316 1.2E-38 T 21-04-2016 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 Gene3D G3DSA:1.10.260.40 1 52 6.0E-20 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS02855 027dc470eb87cf02726e8a14b60730a2 340 SUPERFAMILY SSF47413 1 58 2.25E-14 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 PRINTS PR00298 60kDa chaperonin signature 350 375 9.8E-74 T 21-04-2016 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 PRINTS PR00298 60kDa chaperonin signature 26 52 9.8E-74 T 21-04-2016 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 PRINTS PR00298 60kDa chaperonin signature 398 419 9.8E-74 T 21-04-2016 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 PRINTS PR00298 60kDa chaperonin signature 268 291 9.8E-74 T 21-04-2016 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 PRINTS PR00298 60kDa chaperonin signature 82 109 9.8E-74 T 21-04-2016 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 TIGRFAM TIGR02348 GroEL: chaperonin GroL 2 527 1.2E-261 T 21-04-2016 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 Gene3D G3DSA:1.10.560.10 3 196 1.7E-45 T 21-04-2016 IPR027413 GroEL-like equatorial domain SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 Gene3D G3DSA:1.10.560.10 368 518 1.5E-44 T 21-04-2016 IPR027413 GroEL-like equatorial domain SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 SUPERFAMILY SSF48592 6 133 5.65E-75 T 21-04-2016 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 SUPERFAMILY SSF48592 406 520 5.65E-75 T 21-04-2016 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 ProSitePatterns PS00296 Chaperonins cpn60 signature. 405 416 - T 21-04-2016 IPR018370 Chaperonin Cpn60, conserved site GO:0005524|GO:0005737|GO:0006457 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 Gene3D G3DSA:3.50.7.10 197 367 5.6E-96 T 21-04-2016 IPR027409 GroEL-like apical domain SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 SUPERFAMILY SSF54849 140 206 3.89E-22 T 21-04-2016 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 Hamap MF_00600 60 kDa chaperonin [groL]. 1 544 41.878 T 21-04-2016 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 Pfam PF00118 TCP-1/cpn60 chaperonin family 22 524 3.4E-100 T 21-04-2016 IPR002423 Chaperonin Cpn60/TCP-1 family GO:0005524 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 PANTHER PTHR11353 1 545 1.6E-243 T 21-04-2016 SPH21_RS03715 71c803d3a77a4df3a30428a7733e7f0b 545 SUPERFAMILY SSF52029 184 376 3.89E-86 T 21-04-2016 IPR027409 GroEL-like apical domain SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 SUPERFAMILY SSF81336 223 380 1.1E-32 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 TIGRFAM TIGR01131 ATP_synt_6_or_A: ATP synthase F0, A subunit 164 381 1.1E-39 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 PANTHER PTHR11410:SF0 160 390 2.9E-55 T 21-04-2016 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 PANTHER PTHR11410 160 390 2.9E-55 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 PRINTS PR00123 ATP synthase A subunit signature 232 248 1.5E-20 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 PRINTS PR00123 ATP synthase A subunit signature 312 334 1.5E-20 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 PRINTS PR00123 ATP synthase A subunit signature 292 307 1.5E-20 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 PRINTS PR00123 ATP synthase A subunit signature 367 382 1.5E-20 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 Gene3D G3DSA:1.20.120.220 224 387 2.7E-38 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 Pfam PF00119 ATP synthase A chain 172 380 6.2E-50 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS25775 42a2eefba73e06aa6d0ae45821527d94 390 Hamap MF_01393 ATP synthase subunit a [atpB]. 144 387 13.587 T 21-04-2016 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 SPH21_RS15695 8537af31bfa0e5e850b3eb5a63a4b491 204 Gene3D G3DSA:3.90.79.10 73 200 4.6E-22 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS15695 8537af31bfa0e5e850b3eb5a63a4b491 204 ProSitePatterns PS00893 Nudix box signature. 102 123 - T 21-04-2016 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SPH21_RS15695 8537af31bfa0e5e850b3eb5a63a4b491 204 Pfam PF00293 NUDIX domain 76 183 6.5E-16 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS15695 8537af31bfa0e5e850b3eb5a63a4b491 204 PRINTS PR00502 NUDIX hydrolase family signature 111 126 4.0E-6 T 21-04-2016 IPR020476 NUDIX hydrolase SPH21_RS15695 8537af31bfa0e5e850b3eb5a63a4b491 204 PRINTS PR00502 NUDIX hydrolase family signature 97 111 4.0E-6 T 21-04-2016 IPR020476 NUDIX hydrolase SPH21_RS15695 8537af31bfa0e5e850b3eb5a63a4b491 204 SUPERFAMILY SSF55811 73 199 7.85E-23 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Pfam PF00593 TonB dependent receptor 657 940 2.0E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Pfam PF13715 CarboxypepD_reg-like domain 25 112 1.5E-17 T 21-04-2016 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Pfam PF07715 TonB-dependent Receptor Plug Domain 129 231 8.1E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Gene3D G3DSA:2.40.170.20 467 547 6.4E-72 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Gene3D G3DSA:2.40.170.20 595 924 6.4E-72 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Gene3D G3DSA:2.40.170.20 234 435 6.4E-72 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Gene3D G3DSA:2.60.40.1120 25 101 2.7E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 TIGRFAM TIGR01782 TonB-Xanth-Caul: TonB-dependent receptor 107 941 1.1E-155 T 21-04-2016 IPR010104 Bacterial TonB-dependent receptor SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 Gene3D G3DSA:2.170.130.10 132 233 2.0E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 SUPERFAMILY SSF56935 485 524 9.52E-96 T 21-04-2016 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 SUPERFAMILY SSF56935 568 927 9.52E-96 T 21-04-2016 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 SUPERFAMILY SSF56935 108 455 9.52E-96 T 21-04-2016 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 SUPERFAMILY SSF49452 19 100 4.51E-15 T 21-04-2016 IPR013784 Carbohydrate-binding-like fold GO:0030246 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 PANTHER PTHR30069:SF11 7 866 6.2E-45 T 21-04-2016 SPH21_RS22905 0ac1e0d6a74d484389a9c42dedefb198 942 PANTHER PTHR30069 7 866 6.2E-45 T 21-04-2016 SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 Gene3D G3DSA:1.10.10.10 22 130 2.2E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 Pfam PF00583 Acetyltransferase (GNAT) family 219 296 1.5E-11 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 Pfam PF12802 MarR family 37 95 8.6E-10 T 21-04-2016 SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 SUPERFAMILY SSF55729 164 308 1.34E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 PANTHER PTHR23091 136 298 2.3E-21 T 21-04-2016 SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 PANTHER PTHR23091:SF265 136 298 2.3E-21 T 21-04-2016 SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 SMART SM00347 31 131 0.0072 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 Gene3D G3DSA:3.40.630.30 3 21 2.2E-26 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 Gene3D G3DSA:3.40.630.30 174 305 2.2E-26 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12865 727c8e51f384ad243d2874133d362211 317 SUPERFAMILY SSF46785 10 145 2.14E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22965 5f6dc4799b156e5502f9910b60fb169d 125 SUPERFAMILY SSF46626 54 118 1.05E-8 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS22965 5f6dc4799b156e5502f9910b60fb169d 125 Gene3D G3DSA:1.10.760.10 13 118 5.5E-6 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 PANTHER PTHR24423 153 404 2.1E-32 T 21-04-2016 SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 331 408 2.8E-8 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 SUPERFAMILY SSF47384 196 280 2.55E-13 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 SMART SM00387 323 426 7.7E-12 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 Gene3D G3DSA:1.10.287.130 209 275 3.4E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 Gene3D G3DSA:3.30.565.10 285 408 1.0E-18 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 Pfam PF00512 His Kinase A (phospho-acceptor) domain 214 278 2.7E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 SMART SM00388 213 279 6.0E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS12690 c43da0f8fc5ce8388f7f90718d8caa57 426 SUPERFAMILY SSF55874 283 410 1.26E-19 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 PRINTS PR00741 Glycosyl hydrolase family 29 signature 113 129 5.6E-7 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 PRINTS PR00741 Glycosyl hydrolase family 29 signature 356 378 5.6E-7 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 PANTHER PTHR10030 210 376 5.6E-69 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 PANTHER PTHR10030 7 190 5.6E-69 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 PIRSF PIRSF001092 7 470 1.1E-120 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 SUPERFAMILY SSF51445 34 184 7.16E-99 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 SUPERFAMILY SSF51445 213 373 7.16E-99 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 Gene3D G3DSA:2.60.40.1180 393 461 1.1E-6 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 Pfam PF01120 Alpha-L-fucosidase 34 370 3.7E-92 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 SMART SM00812 25 417 2.8E-119 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14235 70899c4b545e628a9d8b8812d9b44909 484 Gene3D G3DSA:3.20.20.80 34 373 1.5E-101 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS06280 c9342d7d33635de02f293656834c840c 477 Gene3D G3DSA:1.25.40.10 193 287 4.4E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06280 c9342d7d33635de02f293656834c840c 477 Gene3D G3DSA:1.25.40.10 326 420 4.4E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06280 c9342d7d33635de02f293656834c840c 477 SUPERFAMILY SSF48452 15 477 9.86E-100 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06280 c9342d7d33635de02f293656834c840c 477 Pfam PF07980 SusD family 318 477 3.4E-26 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS06280 c9342d7d33635de02f293656834c840c 477 Pfam PF14322 Starch-binding associating with outer membrane 35 212 1.3E-25 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82693 40 134 9.68E-25 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PANTHER PTHR32063 1 1026 0.0 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:1.10.3850.10 807 1020 9.7E-62 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:3.30.2090.10 180 266 5.0E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82693 134 180 1.88E-14 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82693 267 324 1.88E-14 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82714 715 801 1.57E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Pfam PF00873 AcrB/AcrD/AcrF family 3 1019 2.9E-261 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82714 181 264 3.79E-15 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:3.30.70.1430 564 660 1.9E-11 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PRINTS PR00702 Acriflavin resistance protein family signature 330 353 1.8E-45 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PRINTS PR00702 Acriflavin resistance protein family signature 438 461 1.8E-45 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PRINTS PR00702 Acriflavin resistance protein family signature 385 409 1.8E-45 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PRINTS PR00702 Acriflavin resistance protein family signature 38 56 1.8E-45 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PRINTS PR00702 Acriflavin resistance protein family signature 357 378 1.8E-45 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PRINTS PR00702 Acriflavin resistance protein family signature 463 486 1.8E-45 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 PRINTS PR00702 Acriflavin resistance protein family signature 10 34 1.8E-45 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82866 290 491 4.05E-43 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:1.20.1640.10 298 496 3.4E-51 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82693 562 651 3.66E-11 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:3.30.70.1430 41 140 7.5E-27 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 SUPERFAMILY SSF82866 799 1021 8.63E-49 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:3.30.2090.10 714 802 7.1E-20 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:3.30.70.1320 141 177 7.4E-11 T 21-04-2016 SPH21_RS08390 da493ee037a290462632814c0d92819e 1056 Gene3D G3DSA:3.30.70.1320 269 297 7.4E-11 T 21-04-2016 SPH21_RS14215 c40d8ab6ccbf4f831ac885d8abeac9b8 854 Gene3D G3DSA:1.50.10.10 328 418 7.5E-18 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS14215 c40d8ab6ccbf4f831ac885d8abeac9b8 854 Gene3D G3DSA:1.50.10.10 476 595 7.5E-18 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS14215 c40d8ab6ccbf4f831ac885d8abeac9b8 854 Gene3D G3DSA:2.70.98.50 95 327 9.7E-7 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS14215 c40d8ab6ccbf4f831ac885d8abeac9b8 854 Gene3D G3DSA:2.70.98.50 48 93 3.6E-6 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS14215 c40d8ab6ccbf4f831ac885d8abeac9b8 854 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 48 91 2.1E-6 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS14215 c40d8ab6ccbf4f831ac885d8abeac9b8 854 SUPERFAMILY SSF48208 259 423 1.28E-28 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS14215 c40d8ab6ccbf4f831ac885d8abeac9b8 854 SUPERFAMILY SSF48208 483 800 1.28E-28 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Pfam PF00593 TonB dependent receptor 610 1029 6.2E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Pfam PF07715 TonB-dependent Receptor Plug Domain 124 225 1.1E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Pfam PF13715 CarboxypepD_reg-like domain 31 112 1.3E-18 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 30 1031 3.3E-280 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Gene3D G3DSA:2.40.170.20 308 376 4.9E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Gene3D G3DSA:2.40.170.20 225 246 4.9E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Gene3D G3DSA:2.40.170.20 409 796 4.9E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Gene3D G3DSA:2.40.170.20 872 916 4.9E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Gene3D G3DSA:2.40.170.20 951 1031 4.9E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 PANTHER PTHR11532:SF57 1 423 9.2E-270 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 PANTHER PTHR11532:SF57 500 1029 9.2E-270 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Gene3D G3DSA:2.60.40.1120 31 114 1.1E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 PANTHER PTHR11532 1 423 9.2E-270 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 PANTHER PTHR11532 500 1029 9.2E-270 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 SUPERFAMILY SSF56935 108 250 1.14E-88 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 SUPERFAMILY SSF56935 941 1031 1.14E-88 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 SUPERFAMILY SSF56935 863 907 1.14E-88 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 SUPERFAMILY SSF56935 299 391 1.14E-88 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 SUPERFAMILY SSF56935 427 780 1.14E-88 T 21-04-2016 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 201 231 2.0E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 Gene3D G3DSA:2.170.130.10 115 224 1.3E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19490 2a46e6387f6584d4a64c1388480b67a0 1031 SUPERFAMILY SSF49464 30 110 4.71E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS18175 a89d82efe8d3dd24671415bd1fe6376c 373 Gene3D G3DSA:2.130.10.10 92 268 7.1E-23 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS18175 a89d82efe8d3dd24671415bd1fe6376c 373 Gene3D G3DSA:2.130.10.10 320 370 7.1E-23 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS18175 a89d82efe8d3dd24671415bd1fe6376c 373 SUPERFAMILY SSF51004 93 371 2.2E-19 T 21-04-2016 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 17 719 1.4E-149 T 21-04-2016 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 Gene3D G3DSA:3.40.50.620 6 193 1.2E-132 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 Gene3D G3DSA:3.40.50.620 456 726 1.2E-132 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 Gene3D G3DSA:1.10.730.10 727 916 8.0E-48 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 Hamap MF_02003 Isoleucine--tRNA ligase [ileS]. 3 1124 13.178 T 21-04-2016 IPR023586 Isoleucine-tRNA ligase, type 2 GO:0004822 KEGG: 00970+6.1.1.5 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 Gene3D G3DSA:3.90.740.10 237 455 1.1E-45 T 21-04-2016 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 597 610 4.4E-13 T 21-04-2016 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5|Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 40 51 4.4E-13 T 21-04-2016 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5|Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 450 465 4.4E-13 T 21-04-2016 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5|Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946:SF87 1 257 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946:SF87 297 412 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946:SF87 432 542 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946:SF87 578 1029 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 TIGRFAM TIGR00392 ileS: isoleucine--tRNA ligase 4 930 3.0E-292 T 21-04-2016 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5|Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946 1 257 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946 297 412 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946 432 542 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 PANTHER PTHR11946 578 1029 0.0 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 Pfam PF08264 Anticodon-binding domain of tRNA 774 926 2.4E-29 T 21-04-2016 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 SUPERFAMILY SSF47323 1054 1124 8.5E-5 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 SUPERFAMILY SSF52374 452 736 8.68E-120 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 SUPERFAMILY SSF52374 6 197 8.68E-120 T 21-04-2016 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 SUPERFAMILY SSF47323 742 986 1.21E-54 T 21-04-2016 IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS00210 ce08835f836021cf4fa5d49bd4edfaff 1137 SUPERFAMILY SSF50677 229 409 5.76E-30 T 21-04-2016 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 Reactome: REACT_71 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 Gene3D G3DSA:1.10.3210.10 1 118 6.3E-63 T 21-04-2016 IPR006674 HD domain SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 Gene3D G3DSA:1.10.3210.10 155 254 6.3E-63 T 21-04-2016 IPR006674 HD domain SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 Gene3D G3DSA:1.10.3410.10 255 359 2.9E-34 T 21-04-2016 IPR023293 Deoxyguanosinetriphosphate triphosphohydrolase, central domain SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 Pfam PF01966 HD domain 63 152 9.0E-6 T 21-04-2016 IPR006674 HD domain SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 SUPERFAMILY SSF109604 234 439 1.88E-62 T 21-04-2016 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 SUPERFAMILY SSF109604 17 193 1.88E-62 T 21-04-2016 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 Gene3D G3DSA:1.10.3550.10 119 152 3.6E-36 T 21-04-2016 IPR027432 Deoxyguanosinetriphosphate triphosphohydrolase, C-terminal domain SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 Gene3D G3DSA:1.10.3550.10 360 444 3.6E-36 T 21-04-2016 IPR027432 Deoxyguanosinetriphosphate triphosphohydrolase, C-terminal domain SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 PANTHER PTHR11373:SF29 1 138 1.5E-69 T 21-04-2016 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 PANTHER PTHR11373:SF29 154 191 1.5E-69 T 21-04-2016 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 Pfam PF13286 Phosphohydrolase-associated domain 340 438 1.4E-9 T 21-04-2016 IPR026875 Phosphohydrolase-associated domain SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 PANTHER PTHR11373 1 138 1.5E-69 T 21-04-2016 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 PANTHER PTHR11373 154 191 1.5E-69 T 21-04-2016 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 TIGRFAM TIGR01353 dGTP_triPase: putative dGTPase 26 440 6.5E-105 T 21-04-2016 IPR006261 Deoxyguanosinetriphosphate triphosphohydrolase GO:0000287|GO:0008832|GO:0046039 SPH21_RS06150 cda6dd917fd1d79d4779c88bd1995b26 448 SMART SM00471 59 265 1.0E-6 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS01625 e8d42b3170c1e743e55dde7f41ee69d5 143 Gene3D G3DSA:3.30.70.900 31 141 1.2E-38 T 21-04-2016 SPH21_RS01625 e8d42b3170c1e743e55dde7f41ee69d5 143 SUPERFAMILY SSF54909 43 141 2.35E-23 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS01625 e8d42b3170c1e743e55dde7f41ee69d5 143 SMART SM00886 44 142 5.0E-19 T 21-04-2016 IPR013097 Stress responsive alpha-beta barrel SPH21_RS01625 e8d42b3170c1e743e55dde7f41ee69d5 143 Pfam PF07876 Stress responsive A/B Barrel Domain 44 140 8.1E-19 T 21-04-2016 IPR013097 Stress responsive alpha-beta barrel SPH21_RS01625 e8d42b3170c1e743e55dde7f41ee69d5 143 PANTHER PTHR33178 43 139 8.2E-12 T 21-04-2016 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 Hamap MF_00016 Holliday junction ATP-dependent DNA helicase RuvB [ruvB]. 1 340 161.396 T 21-04-2016 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 SUPERFAMILY SSF52540 23 254 1.22E-50 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 TIGRFAM TIGR00635 ruvB: Holliday junction DNA helicase RuvB 27 329 2.5E-138 T 21-04-2016 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 Gene3D G3DSA:1.10.8.60 188 258 1.2E-31 T 21-04-2016 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 ProDom PD005323 DNA HELICASE HOLLIDAY JUNCTION RUVB NUCLEOTIDE-BINDING ATP-BINDING SOS RECOMBINATION RESPONSE 254 331 4.0E-30 T 21-04-2016 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 SMART SM00382 54 185 8.3E-14 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 PANTHER PTHR13779 13 329 2.9E-169 T 21-04-2016 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 Gene3D G3DSA:1.10.10.10 260 329 1.3E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 Gene3D G3DSA:3.40.50.300 23 180 6.9E-32 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 Pfam PF05496 Holliday junction DNA helicase ruvB N-terminus 12 238 7.2E-111 T 21-04-2016 IPR008824 Holliday junction DNA helicase ruvB, N-terminal GO:0006281|GO:0006310|GO:0009378 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 Pfam PF05491 Holliday junction DNA helicase ruvB C-terminus 256 329 5.9E-34 T 21-04-2016 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 PANTHER PTHR13779:SF25 13 329 2.9E-169 T 21-04-2016 SPH21_RS12220 28aa2145732cb7f1d825ca0c86145375 340 SUPERFAMILY SSF46785 260 330 3.06E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20665 fba6e442f987951abaa4e3d3478e9585 67 Pfam PF02525 Flavodoxin-like fold 2 62 1.6E-8 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS20665 fba6e442f987951abaa4e3d3478e9585 67 Gene3D G3DSA:3.40.50.360 1 65 9.4E-12 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS20665 fba6e442f987951abaa4e3d3478e9585 67 SUPERFAMILY SSF52218 1 65 4.83E-10 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS09975 8a908f8ab74d812791be6493a052b8ba 169 SMART SM00738 4 101 0.0046 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS09975 8a908f8ab74d812791be6493a052b8ba 169 PANTHER PTHR30265:SF3 1 169 8.9E-26 T 21-04-2016 SPH21_RS09975 8a908f8ab74d812791be6493a052b8ba 169 Pfam PF02357 Transcription termination factor nusG 5 97 1.3E-16 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS09975 8a908f8ab74d812791be6493a052b8ba 169 PANTHER PTHR30265 1 169 8.9E-26 T 21-04-2016 SPH21_RS09975 8a908f8ab74d812791be6493a052b8ba 169 Gene3D G3DSA:3.30.70.940 5 102 8.9E-11 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS09975 8a908f8ab74d812791be6493a052b8ba 169 SUPERFAMILY SSF82679 4 103 4.71E-21 T 21-04-2016 IPR006645 NusG, N-terminal GO:0006355 SPH21_RS03115 c06a7dd463d700073c0a6978ac34e24e 283 Gene3D G3DSA:3.20.20.150 41 278 4.5E-38 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS03115 c06a7dd463d700073c0a6978ac34e24e 283 Pfam PF01261 Xylose isomerase-like TIM barrel 76 235 4.2E-10 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS03115 c06a7dd463d700073c0a6978ac34e24e 283 SUPERFAMILY SSF51658 42 280 7.07E-39 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS22840 b3d02e0cf24ab00f883715f6b0f18b1f 382 Pfam PF02595 Glycerate kinase family 3 372 6.6E-118 T 21-04-2016 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SPH21_RS22840 b3d02e0cf24ab00f883715f6b0f18b1f 382 SUPERFAMILY SSF110738 1 373 3.14E-102 T 21-04-2016 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SPH21_RS22840 b3d02e0cf24ab00f883715f6b0f18b1f 382 PIRSF PIRSF006078 1 380 1.0E-110 T 21-04-2016 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SPH21_RS22840 b3d02e0cf24ab00f883715f6b0f18b1f 382 PANTHER PTHR21599 1 374 4.1E-102 T 21-04-2016 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SPH21_RS22840 b3d02e0cf24ab00f883715f6b0f18b1f 382 PANTHER PTHR21599:SF0 1 374 4.1E-102 T 21-04-2016 SPH21_RS22840 b3d02e0cf24ab00f883715f6b0f18b1f 382 Gene3D G3DSA:3.90.1510.10 43 275 8.1E-76 T 21-04-2016 IPR018193 Glycerate kinase, flavodoxin-like domain GO:0008887|GO:0031388 SPH21_RS22840 b3d02e0cf24ab00f883715f6b0f18b1f 382 TIGRFAM TIGR00045 TIGR00045: glycerate kinase 2 374 1.1E-109 T 21-04-2016 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 SUPERFAMILY SSF46689 237 285 3.9E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 Pfam PF12833 Helix-turn-helix domain 204 282 8.3E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 PANTHER PTHR11019:SF45 31 289 5.7E-39 T 21-04-2016 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 SMART SM00342 197 281 2.3E-12 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 Gene3D G3DSA:2.60.120.280 36 141 1.0E-4 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 SUPERFAMILY SSF51215 35 142 4.71E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 PANTHER PTHR11019 31 289 5.7E-39 T 21-04-2016 SPH21_RS24000 704d8e63b2a9d371a63de2d931e41865 290 Gene3D G3DSA:1.10.10.60 236 288 4.5E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 PANTHER PTHR11712:SF234 1 133 2.1E-164 T 21-04-2016 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 PANTHER PTHR11712:SF234 162 849 2.1E-164 T 21-04-2016 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 410 7.3E-38 T 21-04-2016 IPR014031 Beta-ketoacyl synthase, C-terminal SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Pfam PF00698 Acyl transferase domain 581 797 7.4E-16 T 21-04-2016 IPR014043 Acyl transferase SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SUPERFAMILY SSF56214 1333 1404 3.14E-13 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SMART SM00825 Beta-ketoacyl synthase 6 461 1.4E-87 T 21-04-2016 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 551 833 2.1E-8 T 21-04-2016 IPR020801 Polyketide synthase, acyl transferase domain SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Gene3D G3DSA:3.40.47.10 2 298 8.7E-70 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Gene3D G3DSA:3.90.470.20 1342 1400 1.3E-8 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Gene3D G3DSA:3.40.366.10 580 650 1.7E-21 T 21-04-2016 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Gene3D G3DSA:3.40.366.10 715 826 1.7E-21 T 21-04-2016 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 1333 1401 4.5E-9 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SUPERFAMILY SSF53901 3 122 1.22E-73 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SUPERFAMILY SSF53901 182 406 1.22E-73 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SUPERFAMILY SSF53901 437 456 1.22E-73 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4 286 2.9E-59 T 21-04-2016 IPR014030 Beta-ketoacyl synthase, N-terminal SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Pfam PF14765 Polyketide synthase dehydratase 955 1197 3.4E-8 T 21-04-2016 IPR020807 Polyketide synthase, dehydratase domain SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 PANTHER PTHR11712 1 133 2.1E-164 T 21-04-2016 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 PANTHER PTHR11712 162 849 2.1E-164 T 21-04-2016 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Gene3D G3DSA:3.40.47.10 299 460 4.0E-50 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Gene3D G3DSA:3.90.470.20 1259 1341 7.7E-5 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 414 477 9.5E-10 T 21-04-2016 IPR032821 Ketoacyl-synthetase, C-terminal extension SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SUPERFAMILY SSF52151 717 820 2.28E-24 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 SUPERFAMILY SSF52151 547 655 2.28E-24 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS18355 6e264fa76e185b83a86a4ad76d337116 1427 Gene3D G3DSA:3.30.70.250 659 705 8.2E-6 T 21-04-2016 SPH21_RS22250 7d0a2c5f7a408e1df261a6c1e0ed1ae8 140 PANTHER PTHR33990:SF1 1 140 6.0E-43 T 21-04-2016 SPH21_RS22250 7d0a2c5f7a408e1df261a6c1e0ed1ae8 140 SUPERFAMILY SSF54593 1 135 2.37E-35 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS22250 7d0a2c5f7a408e1df261a6c1e0ed1ae8 140 Gene3D G3DSA:3.10.180.10 7 138 3.1E-42 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS22250 7d0a2c5f7a408e1df261a6c1e0ed1ae8 140 PANTHER PTHR33990 1 140 6.0E-43 T 21-04-2016 SPH21_RS22250 7d0a2c5f7a408e1df261a6c1e0ed1ae8 140 Pfam PF06983 3-demethylubiquinone-9 3-methyltransferase 2 133 1.9E-11 T 21-04-2016 IPR028973 3-demethylubiquinone-9 3-methyltransferase SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 Pfam PF02951 Prokaryotic glutathione synthetase, N-terminal domain 1 128 1.7E-16 T 21-04-2016 IPR004215 Prokaryotic glutathione synthetase, N-terminal GO:0004363|GO:0006750 KEGG: 00270+6.3.2.3|KEGG: 00480+6.3.2.3|UniPathway: UPA00142 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 Gene3D G3DSA:3.30.470.20 203 313 5.0E-34 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 PANTHER PTHR21621:SF4 79 333 1.3E-49 T 21-04-2016 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 PANTHER PTHR21621:SF4 1 62 1.3E-49 T 21-04-2016 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 Hamap MF_00162 Glutathione synthetase [gshB]. 1 331 83.865 T 21-04-2016 IPR006284 Glutathione synthetase, prokaryotic GO:0004363|GO:0005829|GO:0006750 KEGG: 00270+6.3.2.3|KEGG: 00480+6.3.2.3|UniPathway: UPA00142 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 SUPERFAMILY SSF56059 133 327 1.6E-38 T 21-04-2016 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 Gene3D G3DSA:3.40.50.20 1 137 1.0E-19 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 Gene3D G3DSA:3.30.1490.20 147 202 4.8E-18 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 PANTHER PTHR21621 79 333 1.3E-49 T 21-04-2016 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 PANTHER PTHR21621 1 62 1.3E-49 T 21-04-2016 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 Pfam PF02955 Prokaryotic glutathione synthetase, ATP-grasp domain 133 307 3.8E-51 T 21-04-2016 IPR004218 Prokaryotic glutathione synthetase, ATP-binding GO:0004363|GO:0005524|GO:0006750 KEGG: 00270+6.3.2.3|KEGG: 00480+6.3.2.3|UniPathway: UPA00142 SPH21_RS20440 75d8babf9708019efbe1bc03fa26dd63 333 SUPERFAMILY SSF52440 1 129 4.89E-16 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 SUPERFAMILY SSF46689 259 307 6.72E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 Gene3D G3DSA:1.10.10.60 259 307 3.2E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 PANTHER PTHR11019:SF50 25 307 1.3E-30 T 21-04-2016 SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 288 304 9.4E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 273 288 9.4E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 Pfam PF12833 Helix-turn-helix domain 227 305 2.5E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 PANTHER PTHR11019 25 307 1.3E-30 T 21-04-2016 SPH21_RS23630 e563bbc16cd8ca3720b84eac0556a02a 308 SMART SM00342 221 304 2.5E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS05625 ab235c41b95ba305acf77b24bb8b99e7 62 Pfam PF02416 mttA/Hcf106 family 10 61 3.3E-15 T 21-04-2016 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 SPH21_RS05625 ab235c41b95ba305acf77b24bb8b99e7 62 PANTHER PTHR33162 1 62 6.6E-12 T 21-04-2016 SPH21_RS05625 ab235c41b95ba305acf77b24bb8b99e7 62 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA]. 7 60 17.2 T 21-04-2016 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 SPH21_RS05625 ab235c41b95ba305acf77b24bb8b99e7 62 TIGRFAM TIGR01411 tatAE: twin arginine-targeting protein translocase, TatA/E family 9 53 1.2E-15 T 21-04-2016 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 SPH21_RS07320 40d51f5ef6a1aab92d856d425af8d954 270 Pfam PF12833 Helix-turn-helix domain 197 268 2.5E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS07320 40d51f5ef6a1aab92d856d425af8d954 270 SUPERFAMILY SSF46689 223 268 9.41E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS07320 40d51f5ef6a1aab92d856d425af8d954 270 SMART SM00342 187 270 6.1E-12 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS07320 40d51f5ef6a1aab92d856d425af8d954 270 PANTHER PTHR11019 30 267 4.5E-18 T 21-04-2016 SPH21_RS07320 40d51f5ef6a1aab92d856d425af8d954 270 Gene3D G3DSA:1.10.10.60 224 268 2.8E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS07320 40d51f5ef6a1aab92d856d425af8d954 270 PANTHER PTHR11019:SF50 30 267 4.5E-18 T 21-04-2016 SPH21_RS07320 40d51f5ef6a1aab92d856d425af8d954 270 Gene3D G3DSA:1.10.10.60 178 223 3.2E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 SUPERFAMILY SSF55347 164 194 4.25E-13 T 21-04-2016 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 SUPERFAMILY SSF55347 225 274 4.25E-13 T 21-04-2016 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 40 156 2.7E-15 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 PANTHER PTHR22604 1 191 1.1E-126 T 21-04-2016 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 PANTHER PTHR22604 209 443 1.1E-126 T 21-04-2016 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 SUPERFAMILY SSF51735 27 188 3.49E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 PANTHER PTHR22604:SF101 1 191 1.1E-126 T 21-04-2016 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 PANTHER PTHR22604:SF101 209 443 1.1E-126 T 21-04-2016 SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 Gene3D G3DSA:3.40.50.720 227 273 2.5E-49 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08210 b8f6abaeabdf7aade176f622136d85e0 500 Gene3D G3DSA:3.40.50.720 38 194 2.5E-49 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 8.1E-12 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 Gene3D G3DSA:1.10.357.10 4 200 2.4E-32 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 SUPERFAMILY SSF48498 81 167 1.04E-5 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 SUPERFAMILY SSF46689 4 78 5.99E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 PANTHER PTHR30055 8 162 2.8E-22 T 21-04-2016 SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 ProSitePatterns PS01081 TetR-type HTH domain signature. 23 53 - T 21-04-2016 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 2.2E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS08410 2d8eebfa496f720ee4b65b163582d529 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 2.2E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PANTHER PTHR11706 24 461 1.6E-203 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 Hamap MF_00221 Divalent metal cation transporter MntH [mntH]. 10 428 37.057 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PRINTS PR00447 Natural resistance-associated macrophage protein signature 106 132 2.7E-57 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PRINTS PR00447 Natural resistance-associated macrophage protein signature 159 180 2.7E-57 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PRINTS PR00447 Natural resistance-associated macrophage protein signature 312 331 2.7E-57 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PRINTS PR00447 Natural resistance-associated macrophage protein signature 372 391 2.7E-57 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PRINTS PR00447 Natural resistance-associated macrophage protein signature 134 153 2.7E-57 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PRINTS PR00447 Natural resistance-associated macrophage protein signature 208 231 2.7E-57 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 PRINTS PR00447 Natural resistance-associated macrophage protein signature 340 357 2.7E-57 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 Pfam PF01566 Natural resistance-associated macrophage protein 47 402 2.6E-135 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 TIGRFAM TIGR01197 nramp: metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family 26 396 5.9E-117 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 Gene3D G3DSA:3.40.50.620 484 619 1.2E-22 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 Pfam PF00582 Universal stress protein family 488 619 3.5E-16 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS11685 8d75df1b6a4dda8d6e005af298c32be8 621 SUPERFAMILY SSF52402 488 620 3.52E-22 T 21-04-2016 SPH21_RS19050 b9f4479c0abf644432b3fff4525b85d2 159 Gene3D G3DSA:1.20.1260.10 18 141 2.4E-12 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS19050 b9f4479c0abf644432b3fff4525b85d2 159 PANTHER PTHR38593:SF1 17 158 3.6E-14 T 21-04-2016 SPH21_RS19050 b9f4479c0abf644432b3fff4525b85d2 159 Pfam PF13628 Domain of unknown function (DUF4142) 19 154 1.1E-34 T 21-04-2016 IPR025419 Domain of unknown function DUF4142 SPH21_RS19050 b9f4479c0abf644432b3fff4525b85d2 159 PANTHER PTHR38593 17 158 3.6E-14 T 21-04-2016 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 PANTHER PTHR21109 1 46 2.3E-12 T 21-04-2016 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 ProDom PD005521 RIBOSOMAL S21 RIBONUCLEOPROTEIN 30S S21P A SSU SUBUNIT SEQUENCING DIRECT 26 52 0.004 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 Pfam PF01165 Ribosomal protein S21 4 56 7.8E-20 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 ProSitePatterns PS01181 Ribosomal protein S21 signature. 13 25 - T 21-04-2016 IPR018278 Ribosomal protein S21, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 Hamap MF_00358 30S ribosomal protein S21 [rpsU]. 1 57 19.422 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 TIGRFAM TIGR00030 S21p: ribosomal protein bS21 3 56 4.2E-19 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 PRINTS PR00976 Ribosomal protein S21 family signature 37 47 3.2E-9 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 PRINTS PR00976 Ribosomal protein S21 family signature 25 35 3.2E-9 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 PRINTS PR00976 Ribosomal protein S21 family signature 13 22 3.2E-9 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11820 8e02a9c61b7f2fc4fc999e47c53e09d0 63 PRINTS PR00976 Ribosomal protein S21 family signature 5 13 3.2E-9 T 21-04-2016 IPR001911 Ribosomal protein S21 GO:0003735|GO:0005840|GO:0006412 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 987 4.8E-209 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Gene3D G3DSA:2.60.40.1120 26 92 7.9E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 218 248 2.4E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 SUPERFAMILY SSF56935 827 872 2.79E-84 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 SUPERFAMILY SSF56935 105 266 2.79E-84 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 SUPERFAMILY SSF56935 323 774 2.79E-84 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 SUPERFAMILY SSF56935 904 962 2.79E-84 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Gene3D G3DSA:2.170.130.10 106 242 1.9E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Gene3D G3DSA:2.40.170.20 904 985 5.2E-36 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Gene3D G3DSA:2.40.170.20 837 862 5.2E-36 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Gene3D G3DSA:2.40.170.20 332 803 5.2E-36 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Gene3D G3DSA:2.40.170.20 243 265 5.2E-36 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Pfam PF13715 CarboxypepD_reg-like domain 26 108 4.3E-13 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 PANTHER PTHR11532 457 986 1.4E-184 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 PANTHER PTHR11532 22 191 1.4E-184 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 PANTHER PTHR11532 209 396 1.4E-184 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 Pfam PF07715 TonB-dependent Receptor Plug Domain 118 242 1.1E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 PANTHER PTHR11532:SF57 457 986 1.4E-184 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 PANTHER PTHR11532:SF57 22 191 1.4E-184 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 PANTHER PTHR11532:SF57 209 396 1.4E-184 T 21-04-2016 SPH21_RS01295 8292c44edb06e5a0495378b3ac36056d 988 SUPERFAMILY SSF49464 26 90 1.01E-9 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS22850 05ecd6bf57ba9a30adf2f28cc1421732 347 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 35 345 1.7E-49 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS22850 05ecd6bf57ba9a30adf2f28cc1421732 347 SUPERFAMILY SSF111369 65 267 4.18E-18 T 21-04-2016 SPH21_RS22850 05ecd6bf57ba9a30adf2f28cc1421732 347 Gene3D G3DSA:2.40.50.100 154 185 2.4E-14 T 21-04-2016 SPH21_RS22850 05ecd6bf57ba9a30adf2f28cc1421732 347 Gene3D G3DSA:2.40.50.100 67 93 2.4E-14 T 21-04-2016 SPH21_RS22850 05ecd6bf57ba9a30adf2f28cc1421732 347 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 47 224 4.3E-14 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS22850 05ecd6bf57ba9a30adf2f28cc1421732 347 PANTHER PTHR30469:SF15 7 345 3.4E-45 T 21-04-2016 SPH21_RS22850 05ecd6bf57ba9a30adf2f28cc1421732 347 PANTHER PTHR30469 7 345 3.4E-45 T 21-04-2016 SPH21_RS12030 fff0891859180fea354cb102b71fe6ab 195 Pfam PF01569 PAP2 superfamily 64 183 1.4E-23 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS12030 fff0891859180fea354cb102b71fe6ab 195 SUPERFAMILY SSF48317 8 185 1.57E-33 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS12030 fff0891859180fea354cb102b71fe6ab 195 Gene3D G3DSA:1.20.144.10 7 184 5.7E-33 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS12030 fff0891859180fea354cb102b71fe6ab 195 SMART SM00014 59 180 4.6E-21 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS12030 fff0891859180fea354cb102b71fe6ab 195 PANTHER PTHR14969 1 188 3.7E-34 T 21-04-2016 SPH21_RS00925 b0f5314a7d1cca770ee5aa1d5057c53e 420 Pfam PF10022 Uncharacterized protein conserved in bacteria (DUF2264) 42 401 5.1E-112 T 21-04-2016 IPR016624 Uncharacterised conserved protein UCP014753 SPH21_RS00925 b0f5314a7d1cca770ee5aa1d5057c53e 420 PANTHER PTHR35339 30 415 2.3E-157 T 21-04-2016 SPH21_RS00925 b0f5314a7d1cca770ee5aa1d5057c53e 420 PIRSF PIRSF014753 21 411 7.4E-107 T 21-04-2016 IPR016624 Uncharacterised conserved protein UCP014753 SPH21_RS00925 b0f5314a7d1cca770ee5aa1d5057c53e 420 SUPERFAMILY SSF48230 145 307 5.95E-6 T 21-04-2016 IPR008929 Chondroitin AC/alginate lyase SPH21_RS00925 b0f5314a7d1cca770ee5aa1d5057c53e 420 PANTHER PTHR35339:SF3 30 415 2.3E-157 T 21-04-2016 SPH21_RS13180 d20449923a989b4b0c5839d18f4de133 365 Gene3D G3DSA:2.115.10.20 37 351 2.4E-74 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS13180 d20449923a989b4b0c5839d18f4de133 365 PANTHER PTHR22925:SF30 218 356 3.7E-95 T 21-04-2016 SPH21_RS13180 d20449923a989b4b0c5839d18f4de133 365 PANTHER PTHR22925:SF30 39 195 3.7E-95 T 21-04-2016 SPH21_RS13180 d20449923a989b4b0c5839d18f4de133 365 SUPERFAMILY SSF75005 40 357 9.29E-61 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS13180 d20449923a989b4b0c5839d18f4de133 365 PANTHER PTHR22925 218 356 3.7E-95 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS13180 d20449923a989b4b0c5839d18f4de133 365 PANTHER PTHR22925 39 195 3.7E-95 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS13180 d20449923a989b4b0c5839d18f4de133 365 Pfam PF04616 Glycosyl hydrolases family 43 105 350 1.1E-26 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS06165 5c9c07cb3ba0c4fda8708d00e45f43f1 366 PANTHER PTHR19353:SF14 16 359 2.2E-52 T 21-04-2016 SPH21_RS06165 5c9c07cb3ba0c4fda8708d00e45f43f1 366 Pfam PF00487 Fatty acid desaturase 68 338 3.0E-32 T 21-04-2016 IPR005804 Fatty acid desaturase domain GO:0006629 SPH21_RS06165 5c9c07cb3ba0c4fda8708d00e45f43f1 366 PANTHER PTHR19353 16 359 2.2E-52 T 21-04-2016 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 SUPERFAMILY SSF75005 28 363 2.09E-77 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 PANTHER PTHR22925 251 361 7.1E-63 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 PANTHER PTHR22925 25 186 7.1E-63 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 PANTHER PTHR22925 207 227 7.1E-63 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 Pfam PF04616 Glycosyl hydrolases family 43 29 361 2.3E-57 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 PANTHER PTHR22925:SF42 251 361 7.1E-63 T 21-04-2016 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 PANTHER PTHR22925:SF42 25 186 7.1E-63 T 21-04-2016 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 PANTHER PTHR22925:SF42 207 227 7.1E-63 T 21-04-2016 SPH21_RS22055 0f3353e4cdfc0206336086bba9a5b8fe 377 Gene3D G3DSA:2.115.10.20 24 372 3.2E-95 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS03775 ef7dd83bc25155c8e0fda0cd02f42336 211 PANTHER PTHR10509 5 211 8.9E-58 T 21-04-2016 SPH21_RS03775 ef7dd83bc25155c8e0fda0cd02f42336 211 PANTHER PTHR10509:SF14 5 211 8.9E-58 T 21-04-2016 SPH21_RS03775 ef7dd83bc25155c8e0fda0cd02f42336 211 Gene3D G3DSA:3.40.50.150 5 210 3.4E-65 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS03775 ef7dd83bc25155c8e0fda0cd02f42336 211 SUPERFAMILY SSF53335 8 210 5.31E-40 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS03775 ef7dd83bc25155c8e0fda0cd02f42336 211 Pfam PF01596 O-methyltransferase 14 210 2.5E-50 T 21-04-2016 IPR002935 O-methyltransferase, family 3 GO:0008171 SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 1.8E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 1.8E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 1.8E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.8E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 1.8E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 1.8E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 2.8E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 2.8E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 2.8E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PANTHER PTHR24322 11 140 2.3E-49 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 PANTHER PTHR24322 156 188 2.3E-49 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 Gene3D G3DSA:3.40.50.720 4 247 2.1E-83 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 SUPERFAMILY SSF51735 6 248 8.92E-79 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 247 5.5E-67 T 21-04-2016 SPH21_RS21810 d8bb071e642e4308342480e1cc495327 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 SMART SM00812 41 499 3.5E-144 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 Pfam PF01120 Alpha-L-fucosidase 32 431 3.3E-96 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 PIRSF PIRSF001092 13 548 1.3E-59 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 SUPERFAMILY SSF51445 263 433 3.68E-80 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 SUPERFAMILY SSF51445 42 211 3.68E-80 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 Pfam PF16757 Alpha-L-fucosidase C-terminal domain 470 550 5.8E-11 T 21-04-2016 IPR031919 Alpha-L-fucosidase, C-terminal KEGG: 00511+3.2.1.51 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 Gene3D G3DSA:3.20.20.80 266 433 4.8E-95 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 Gene3D G3DSA:3.20.20.80 38 214 4.8E-95 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 PANTHER PTHR10030 6 209 1.1E-54 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 PANTHER PTHR10030 261 498 1.1E-54 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23670 7d4168eaf4c42f9a3001cd01a394c6ba 550 Gene3D G3DSA:2.60.40.1180 465 549 5.0E-14 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 ProSitePatterns PS00221 MIP family signature. 62 70 - T 21-04-2016 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 TIGRFAM TIGR00861 MIP: MIP family channel proteins 6 240 1.7E-53 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PANTHER PTHR19139 1 243 9.5E-83 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PRINTS PR00783 Major intrinsic protein family signature 44 68 7.56E-48 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PRINTS PR00783 Major intrinsic protein family signature 136 154 7.56E-48 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PRINTS PR00783 Major intrinsic protein family signature 81 100 7.56E-48 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PRINTS PR00783 Major intrinsic protein family signature 2 21 7.56E-48 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PRINTS PR00783 Major intrinsic protein family signature 176 198 7.56E-48 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PRINTS PR00783 Major intrinsic protein family signature 223 243 7.56E-48 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 PANTHER PTHR19139:SF147 1 243 9.5E-83 T 21-04-2016 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 Pfam PF00230 Major intrinsic protein 4 240 2.4E-44 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 SUPERFAMILY SSF81338 2 242 5.76E-67 T 21-04-2016 IPR023271 Aquaporin-like SPH21_RS14460 124b6e08db62b91e0b0915e7d3882dfb 244 Gene3D G3DSA:1.20.1080.10 2 242 2.8E-81 T 21-04-2016 IPR023271 Aquaporin-like SPH21_RS07370 6f41a39d562db4096a67411a9dc89c6b 189 Pfam PF07609 Protein of unknown function (DUF1572) 8 166 5.7E-74 T 21-04-2016 IPR011466 Protein of unknown function DUF1572 SPH21_RS07370 6f41a39d562db4096a67411a9dc89c6b 189 Gene3D G3DSA:1.20.120.450 10 151 1.2E-15 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS07370 6f41a39d562db4096a67411a9dc89c6b 189 SUPERFAMILY SSF109854 9 155 5.8E-20 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 Gene3D G3DSA:3.40.50.620 243 251 1.6E-49 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 Gene3D G3DSA:3.40.50.620 8 210 1.6E-49 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 TIGRFAM TIGR02039 CysD: sulfate adenylyltransferase, small subunit 9 301 1.3E-127 T 21-04-2016 IPR011784 Sulphate adenylyltransferase, small subunit GO:0004781|GO:0019419 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932|UniPathway: UPA00140 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 PANTHER PTHR23293 244 301 4.0E-76 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 PANTHER PTHR23293 178 211 4.0E-76 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 PANTHER PTHR23293 1 158 4.0E-76 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 PANTHER PTHR23293:SF6 244 301 4.0E-76 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 PANTHER PTHR23293:SF6 178 211 4.0E-76 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 PANTHER PTHR23293:SF6 1 158 4.0E-76 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 PIRSF PIRSF002936 1 301 2.4E-136 T 21-04-2016 IPR011784 Sulphate adenylyltransferase, small subunit GO:0004781|GO:0019419 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932|UniPathway: UPA00140 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 SUPERFAMILY SSF52402 6 210 5.29E-65 T 21-04-2016 SPH21_RS15910 b43ccbe3dd7e2e3e43cd13295154d963 301 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family 30 256 1.4E-45 T 21-04-2016 IPR002500 Phosphoadenosine phosphosulphate reductase GO:0003824|GO:0008152 SPH21_RS02455 d81aee8c87ccf9a9e629f0a9bba0c15d 459 PANTHER PTHR33886 56 458 8.3E-102 T 21-04-2016 SPH21_RS02455 d81aee8c87ccf9a9e629f0a9bba0c15d 459 Gene3D G3DSA:1.50.10.10 80 445 3.3E-98 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS02455 d81aee8c87ccf9a9e629f0a9bba0c15d 459 PANTHER PTHR33886:SF2 56 458 8.3E-102 T 21-04-2016 SPH21_RS02455 d81aee8c87ccf9a9e629f0a9bba0c15d 459 Pfam PF07470 Glycosyl Hydrolase Family 88 81 443 5.7E-91 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS02455 d81aee8c87ccf9a9e629f0a9bba0c15d 459 SUPERFAMILY SSF48208 95 444 6.63E-54 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS04590 23e4dae9d0d5fa295e85d99b18790856 149 Gene3D G3DSA:3.30.530.20 2 145 2.0E-39 T 21-04-2016 IPR023393 START-like domain SPH21_RS04590 23e4dae9d0d5fa295e85d99b18790856 149 PANTHER PTHR36929 1 149 3.7E-25 T 21-04-2016 SPH21_RS04590 23e4dae9d0d5fa295e85d99b18790856 149 SUPERFAMILY SSF55961 2 144 2.75E-40 T 21-04-2016 SPH21_RS04590 23e4dae9d0d5fa295e85d99b18790856 149 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 13 142 6.6E-26 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS04590 23e4dae9d0d5fa295e85d99b18790856 149 PANTHER PTHR36929:SF1 1 149 3.7E-25 T 21-04-2016 SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 SMART SM00418 4 82 1.9E-20 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 SUPERFAMILY SSF46785 4 95 1.03E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 PANTHER PTHR33154 1 94 1.9E-20 T 21-04-2016 SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 53 68 3.7E-11 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 38 53 3.7E-11 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 6 21 3.7E-11 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 PANTHER PTHR33154:SF6 1 94 1.9E-20 T 21-04-2016 SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 Gene3D G3DSA:1.10.10.10 4 103 2.4E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24755 9a4ce172f984ce04df9e4dfb654954d8 104 Pfam PF12840 Helix-turn-helix domain 4 62 4.8E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 PANTHER PTHR12143 14 767 0.0 T 21-04-2016 SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 Pfam PF07971 Glycosyl hydrolase family 92 251 748 4.8E-168 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 Gene3D G3DSA:3.30.2080.10 613 760 2.8E-67 T 21-04-2016 SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 Gene3D G3DSA:1.20.1050.60 360 448 9.7E-32 T 21-04-2016 SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 PANTHER PTHR12143:SF22 14 767 0.0 T 21-04-2016 SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 Gene3D G3DSA:2.70.98.10 35 333 1.0E-103 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 SUPERFAMILY SSF48208 277 735 2.81E-35 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 25 753 4.9E-249 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS10145 06ce1b81dff97a00a34b7996f9957e4c 770 Gene3D G3DSA:1.20.1610.10 453 612 2.3E-66 T 21-04-2016 SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 Pfam PF00085 Thioredoxin 122 218 2.0E-26 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 SUPERFAMILY SSF52833 98 219 4.73E-32 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 SUPERFAMILY SSF52821 9 117 5.11E-30 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 SMART SM00450 12 109 3.0E-26 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 Pfam PF00581 Rhodanese-like domain 11 105 1.8E-19 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 Gene3D G3DSA:3.40.250.10 3 117 4.9E-33 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 PANTHER PTHR10438 123 218 4.9E-31 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS01905 3d1f100d845379f978dcabb39dbe4ab2 220 Gene3D G3DSA:3.40.30.10 123 219 1.2E-30 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS16075 ef9647420dbe69313dfbbe4eed1fd0d0 249 PANTHER PTHR22936 15 33 1.1E-31 T 21-04-2016 IPR002610 Peptidase S54, rhomboid GO:0004252|GO:0006508|GO:0016021 SPH21_RS16075 ef9647420dbe69313dfbbe4eed1fd0d0 249 PANTHER PTHR22936 66 246 1.1E-31 T 21-04-2016 IPR002610 Peptidase S54, rhomboid GO:0004252|GO:0006508|GO:0016021 SPH21_RS16075 ef9647420dbe69313dfbbe4eed1fd0d0 249 Pfam PF01694 Rhomboid family 89 242 7.6E-31 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS16075 ef9647420dbe69313dfbbe4eed1fd0d0 249 Gene3D G3DSA:1.20.1540.10 72 239 2.4E-37 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS16075 ef9647420dbe69313dfbbe4eed1fd0d0 249 Gene3D G3DSA:1.20.1540.10 15 38 2.4E-37 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS16075 ef9647420dbe69313dfbbe4eed1fd0d0 249 SUPERFAMILY SSF144091 84 247 4.45E-36 T 21-04-2016 SPH21_RS16075 ef9647420dbe69313dfbbe4eed1fd0d0 249 SUPERFAMILY SSF144091 12 48 4.45E-36 T 21-04-2016 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 Gene3D G3DSA:3.90.79.10 2 140 2.0E-23 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 Pfam PF00293 NUDIX domain 3 143 5.7E-13 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 ProSitePatterns PS00893 Nudix box signature. 42 63 - T 21-04-2016 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 PANTHER PTHR21340 1 101 1.5E-27 T 21-04-2016 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 PANTHER PTHR21340 118 155 1.5E-27 T 21-04-2016 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 SUPERFAMILY SSF55811 2 150 7.85E-20 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 PANTHER PTHR21340:SF1 1 101 1.5E-27 T 21-04-2016 SPH21_RS18340 8b41f6cb344e1a3fcdc59430849a9f61 156 PANTHER PTHR21340:SF1 118 155 1.5E-27 T 21-04-2016 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 Pfam PF01965 DJ-1/PfpI family 63 168 5.0E-8 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 SMART SM00342 237 320 3.6E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 SUPERFAMILY SSF46689 220 271 1.97E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 Pfam PF12833 Helix-turn-helix domain 243 321 3.4E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 Gene3D G3DSA:1.10.10.60 274 326 1.5E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 PANTHER PTHR11019:SF68 42 328 6.8E-47 T 21-04-2016 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 SUPERFAMILY SSF52317 7 200 8.46E-27 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 Gene3D G3DSA:3.40.50.880 21 226 1.7E-37 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 Gene3D G3DSA:1.10.10.60 227 273 1.0E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 SUPERFAMILY SSF46689 274 323 3.36E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12805 2604bb5de7053806dabc25c998ff551d 333 PANTHER PTHR11019 42 328 6.8E-47 T 21-04-2016 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 Pfam PF02403 Seryl-tRNA synthetase N-terminal domain 1 111 1.5E-22 T 21-04-2016 IPR015866 Serine-tRNA synthetase, type1, N-terminal KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 PANTHER PTHR11778 1 422 1.5E-164 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 TIGRFAM TIGR00414 serS: serine--tRNA ligase 1 416 6.4E-135 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 PRINTS PR00981 Seryl-tRNA synthetase signature 353 369 3.9E-21 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 PRINTS PR00981 Seryl-tRNA synthetase signature 278 291 3.9E-21 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 PRINTS PR00981 Seryl-tRNA synthetase signature 318 331 3.9E-21 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 PRINTS PR00981 Seryl-tRNA synthetase signature 266 278 3.9E-21 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 PRINTS PR00981 Seryl-tRNA synthetase signature 335 351 3.9E-21 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 Gene3D G3DSA:1.10.287.40 2 108 2.5E-22 T 21-04-2016 IPR015866 Serine-tRNA synthetase, type1, N-terminal KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|UniPathway: UPA00906 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 Gene3D G3DSA:3.30.930.10 109 419 1.6E-118 T 21-04-2016 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 225 401 8.6E-33 T 21-04-2016 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 SUPERFAMILY SSF46589 1 116 2.93E-22 T 21-04-2016 IPR010978 tRNA-binding arm GO:0000166 Reactome: REACT_71 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 SUPERFAMILY SSF55681 120 421 1.86E-91 T 21-04-2016 SPH21_RS25695 defbb1000c3679b49247aba17d9e3822 423 PIRSF PIRSF001529 1 422 6.3E-145 T 21-04-2016 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281|Reactome: REACT_71|UniPathway: UPA00906 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 SMART SM00812 18 376 1.9E-121 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 PANTHER PTHR10030 32 373 2.3E-70 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 SUPERFAMILY SSF51445 27 335 1.38E-91 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 PRINTS PR00741 Glycosyl hydrolase family 29 signature 285 306 6.5E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 PRINTS PR00741 Glycosyl hydrolase family 29 signature 145 164 6.5E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 PRINTS PR00741 Glycosyl hydrolase family 29 signature 318 340 6.5E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 PRINTS PR00741 Glycosyl hydrolase family 29 signature 98 114 6.5E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 Pfam PF01120 Alpha-L-fucosidase 22 332 1.0E-89 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 Gene3D G3DSA:2.60.40.1180 354 422 2.8E-6 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS16800 bff8b5e319b7350d072addc90b032b45 609 Gene3D G3DSA:3.20.20.80 21 335 2.9E-95 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 TIGRFAM TIGR00674 dapA: 4-hydroxy-tetrahydrodipicolinate synthase 9 288 4.3E-99 T 21-04-2016 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 Pfam PF00701 Dihydrodipicolinate synthetase family 6 288 4.0E-89 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 PRINTS PR00146 Dihydrodipicolinate synthase signature 37 58 2.5E-27 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 PRINTS PR00146 Dihydrodipicolinate synthase signature 73 91 2.5E-27 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 PRINTS PR00146 Dihydrodipicolinate synthase signature 130 147 2.5E-27 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 PRINTS PR00146 Dihydrodipicolinate synthase signature 105 121 2.5E-27 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 PANTHER PTHR12128 4 291 5.1E-116 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 PIRSF PIRSF001365 1 300 1.6E-89 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 Hamap MF_00418 4-hydroxy-tetrahydrodipicolinate synthase [dapA]. 3 290 57.272 T 21-04-2016 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 ProSitePatterns PS00666 Dihydrodipicolinate synthase signature 2. 135 166 - T 21-04-2016 IPR020625 Schiff base-forming aldolase, active site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 Gene3D G3DSA:3.20.20.70 1 291 5.8E-108 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 PANTHER PTHR12128:SF34 4 291 5.1E-116 T 21-04-2016 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 SMART SM01130 3 292 6.9E-119 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS00245 a3623ad690854bbb6e1519979f260248 301 SUPERFAMILY SSF51569 3 288 2.93E-96 T 21-04-2016 SPH21_RS06170 63fa597db3d075b1f0f739256f5cad2a 278 PANTHER PTHR11019 187 278 2.9E-16 T 21-04-2016 SPH21_RS06170 63fa597db3d075b1f0f739256f5cad2a 278 Pfam PF12833 Helix-turn-helix domain 195 273 1.5E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS06170 63fa597db3d075b1f0f739256f5cad2a 278 SUPERFAMILY SSF46689 225 274 1.57E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06170 63fa597db3d075b1f0f739256f5cad2a 278 PANTHER PTHR11019:SF126 187 278 2.9E-16 T 21-04-2016 SPH21_RS06170 63fa597db3d075b1f0f739256f5cad2a 278 Gene3D G3DSA:1.10.10.60 173 225 6.0E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06170 63fa597db3d075b1f0f739256f5cad2a 278 Gene3D G3DSA:1.10.10.60 226 275 1.3E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06170 63fa597db3d075b1f0f739256f5cad2a 278 SMART SM00342 188 271 1.5E-11 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 SMART SM00533 11 315 7.4E-6 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 PANTHER PTHR11361:SF14 15 607 7.3E-175 T 21-04-2016 IPR005747 Endonuclease MutS2 GO:0004519|GO:0016887|GO:0030983|GO:0045910 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 SUPERFAMILY SSF52540 293 521 7.14E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 SUPERFAMILY SSF160443 713 788 1.7E-9 T 21-04-2016 IPR002625 Smr domain SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 PIRSF PIRSF005814 3 789 6.6E-199 T 21-04-2016 IPR005747 Endonuclease MutS2 GO:0004519|GO:0016887|GO:0030983|GO:0045910 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 Pfam PF00488 MutS domain V 338 518 1.4E-34 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 PANTHER PTHR11361 15 607 7.3E-175 T 21-04-2016 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 Gene3D G3DSA:3.40.50.300 293 520 2.0E-59 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 SMART SM00463 711 789 2.6E-14 T 21-04-2016 IPR002625 Smr domain SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 SMART SM00534 334 519 2.1E-57 T 21-04-2016 IPR000432 DNA mismatch repair protein MutS, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 SUPERFAMILY SSF48334 24 288 5.62E-18 T 21-04-2016 IPR007696 DNA mismatch repair protein MutS, core GO:0005524|GO:0006298|GO:0030983 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 TIGRFAM TIGR01069 mutS2: MutS2 family protein 7 788 1.7E-176 T 21-04-2016 IPR005747 Endonuclease MutS2 GO:0004519|GO:0016887|GO:0030983|GO:0045910 SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 Pfam PF01713 Smr domain 714 788 2.4E-20 T 21-04-2016 IPR002625 Smr domain SPH21_RS23025 efebda579b341dbac1daf506391b9913 789 Hamap MF_00092 Endonuclease MutS2 [mutS2]. 4 788 18.195 T 21-04-2016 IPR005747 Endonuclease MutS2 GO:0004519|GO:0016887|GO:0030983|GO:0045910 SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 Pfam PF00676 Dehydrogenase E1 component 50 360 7.7E-26 T 21-04-2016 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 Pfam PF02780 Transketolase, C-terminal domain 663 768 4.9E-19 T 21-04-2016 IPR033248 Transketolase, C-terminal domain SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 Gene3D G3DSA:3.40.50.920 662 793 2.0E-25 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 SMART SM00861 471 645 9.0E-26 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 Gene3D G3DSA:3.40.50.970 471 661 4.8E-42 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 SUPERFAMILY SSF52922 655 793 1.15E-22 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 PANTHER PTHR11624:SF21 186 355 2.4E-61 T 21-04-2016 SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 PANTHER PTHR11624:SF21 454 731 2.4E-61 T 21-04-2016 SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 SUPERFAMILY SSF52518 471 659 1.0E-41 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 SUPERFAMILY SSF52518 24 370 1.21E-48 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 PANTHER PTHR11624 186 355 2.4E-61 T 21-04-2016 IPR033247 Transketolase family SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 PANTHER PTHR11624 454 731 2.4E-61 T 21-04-2016 IPR033247 Transketolase family SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 Pfam PF02779 Transketolase, pyrimidine binding domain 471 643 2.1E-20 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS16020 72ced56b03e894fd2d9bfdeba270efad 805 Gene3D G3DSA:3.40.50.970 22 388 3.3E-86 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 SUPERFAMILY SSF81464 161 255 7.52E-14 T 21-04-2016 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain GO:0016021|GO:0022900 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 Pfam PF02790 Cytochrome C oxidase subunit II, transmembrane domain 172 249 1.1E-8 T 21-04-2016 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain GO:0016021|GO:0022900 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 Pfam PF00116 Cytochrome C oxidase subunit II, periplasmic domain 317 402 4.2E-8 T 21-04-2016 IPR002429 Cytochrome c oxidase subunit II C-terminal GO:0004129|GO:0005507|GO:0016020 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 Gene3D G3DSA:2.60.40.420 259 433 1.9E-33 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 PANTHER PTHR22888:SF2 169 417 8.1E-46 T 21-04-2016 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 Gene3D G3DSA:1.10.287.90 167 257 6.1E-14 T 21-04-2016 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain GO:0016021|GO:0022900 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 SUPERFAMILY SSF49503 264 417 1.75E-31 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 PRINTS PR01166 Cytochrome c oxidase subunit II signature 313 334 8.9E-6 T 21-04-2016 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 PRINTS PR01166 Cytochrome c oxidase subunit II signature 337 357 8.9E-6 T 21-04-2016 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 PRINTS PR01166 Cytochrome c oxidase subunit II signature 225 237 8.9E-6 T 21-04-2016 SPH21_RS07690 33b0708ed5824ef0ad85d7f5075d87e3 451 PANTHER PTHR22888 169 417 8.1E-46 T 21-04-2016 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 223 8.8E-25 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 Gene3D G3DSA:3.40.50.2300 2 121 6.5E-38 T 21-04-2016 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 SUPERFAMILY SSF46894 130 224 2.44E-25 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 SMART SM00862 148 223 2.5E-25 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 PANTHER PTHR26402:SF578 2 225 1.4E-86 T 21-04-2016 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 Pfam PF00072 Response regulator receiver domain 4 114 1.5E-25 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 SUPERFAMILY SSF52172 1 125 2.28E-37 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 Gene3D G3DSA:1.10.10.10 129 225 1.2E-27 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 SMART SM00448 2 113 2.8E-38 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS08105 ddaa661d892b99e7400ef16d7e84757a 228 PANTHER PTHR26402 2 225 1.4E-86 T 21-04-2016 SPH21_RS06010 8470be8c67afd611ffcfb75118d1ff5c 309 PANTHER PTHR30489:SF14 1 180 1.8E-16 T 21-04-2016 SPH21_RS06010 8470be8c67afd611ffcfb75118d1ff5c 309 Pfam PF12704 MacB-like periplasmic core domain 20 255 1.8E-23 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS06010 8470be8c67afd611ffcfb75118d1ff5c 309 PANTHER PTHR30489 1 180 1.8E-16 T 21-04-2016 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 181 1.3E-8 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 165 1.3E-8 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 193 1.3E-8 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 PANTHER PTHR26402:SF458 1 197 1.7E-42 T 21-04-2016 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 Pfam PF00196 Bacterial regulatory proteins, luxR family 150 199 4.1E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 SUPERFAMILY SSF46894 144 201 9.18E-14 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 Pfam PF00072 Response regulator receiver domain 3 114 1.5E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 Gene3D G3DSA:3.40.50.2300 1 118 2.1E-25 T 21-04-2016 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 Gene3D G3DSA:1.10.10.10 119 198 1.2E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 SMART SM00448 1 114 1.6E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 SMART SM00421 148 205 5.5E-10 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 SUPERFAMILY SSF52172 1 131 1.17E-26 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10320 e84ab18663a2e40689593aa7132161a8 212 PANTHER PTHR26402 1 197 1.7E-42 T 21-04-2016 SPH21_RS20975 fa326f3717b03e728bb2f17da777d447 297 SUPERFAMILY SSF103481 39 149 2.35E-7 T 21-04-2016 SPH21_RS20975 fa326f3717b03e728bb2f17da777d447 297 Pfam PF00892 EamA-like transporter family 154 283 3.8E-13 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS20975 fa326f3717b03e728bb2f17da777d447 297 Pfam PF00892 EamA-like transporter family 3 146 1.8E-13 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS20975 fa326f3717b03e728bb2f17da777d447 297 PANTHER PTHR22911 4 297 3.2E-34 T 21-04-2016 SPH21_RS20975 fa326f3717b03e728bb2f17da777d447 297 SUPERFAMILY SSF103481 187 284 1.7E-10 T 21-04-2016 SPH21_RS20975 fa326f3717b03e728bb2f17da777d447 297 PANTHER PTHR22911:SF41 4 297 3.2E-34 T 21-04-2016 SPH21_RS05185 a36290e30bf79fadde765e2d3d537608 214 Gene3D G3DSA:3.40.50.10420 45 209 3.8E-37 T 21-04-2016 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SPH21_RS05185 a36290e30bf79fadde765e2d3d537608 214 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 47 208 1.8E-23 T 21-04-2016 IPR003741 LUD domain SPH21_RS05185 a36290e30bf79fadde765e2d3d537608 214 PANTHER PTHR32479 64 213 5.6E-19 T 21-04-2016 SPH21_RS05185 a36290e30bf79fadde765e2d3d537608 214 PANTHER PTHR32479:SF11 64 213 5.6E-19 T 21-04-2016 SPH21_RS05185 a36290e30bf79fadde765e2d3d537608 214 SUPERFAMILY SSF100950 45 209 1.46E-34 T 21-04-2016 SPH21_RS23640 4a93a7c813319090d4fb1ce4a9c76096 287 Pfam PF00480 ROK family 7 154 8.1E-9 T 21-04-2016 IPR000600 ROK family SPH21_RS23640 4a93a7c813319090d4fb1ce4a9c76096 287 Pfam PF00480 ROK family 173 286 9.6E-11 T 21-04-2016 IPR000600 ROK family SPH21_RS23640 4a93a7c813319090d4fb1ce4a9c76096 287 SUPERFAMILY SSF53067 4 285 1.7E-30 T 21-04-2016 SPH21_RS23640 4a93a7c813319090d4fb1ce4a9c76096 287 Gene3D G3DSA:3.30.420.40 3 157 1.2E-17 T 21-04-2016 SPH21_RS23640 4a93a7c813319090d4fb1ce4a9c76096 287 Gene3D G3DSA:3.30.420.40 171 261 2.7E-12 T 21-04-2016 SPH21_RS05805 5cfc204343991aa714acaf77ed1c599b 298 Gene3D G3DSA:3.40.50.1240 155 285 4.2E-13 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS05805 5cfc204343991aa714acaf77ed1c599b 298 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 190 243 6.0E-7 T 21-04-2016 IPR013078 Histidine phosphatase superfamily, clade-1 SPH21_RS05805 5cfc204343991aa714acaf77ed1c599b 298 SUPERFAMILY SSF53254 187 244 1.7E-11 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 Gene3D G3DSA:3.60.10.10 1 255 4.5E-94 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 TIGRFAM TIGR00195 exoDNase_III: exodeoxyribonuclease III 1 253 5.6E-85 T 21-04-2016 SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 5 246 1.0E-28 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 SUPERFAMILY SSF56219 1 254 9.68E-81 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 ProSitePatterns PS00726 AP endonucleases family 1 signature 1. 28 37 - T 21-04-2016 IPR020847 AP endonuclease 1, binding site GO:0003677|GO:0004519|GO:0005622|GO:0006281 SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 TIGRFAM TIGR00633 xth: exodeoxyribonuclease III (xth) 1 254 1.1E-90 T 21-04-2016 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 ProSitePatterns PS00727 AP endonucleases family 1 signature 2. 189 204 - T 21-04-2016 IPR020848 AP endonuclease 1, conserved site GO:0003677|GO:0004519|GO:0005622|GO:0006281 SPH21_RS06845 5d879330b12aba216bd3ed345534231d 255 PANTHER PTHR22748 1 254 1.1E-111 T 21-04-2016 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Pfam PF00575 S1 RNA binding domain 254 326 1.0E-19 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Pfam PF00575 S1 RNA binding domain 516 581 3.0E-6 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Pfam PF00575 S1 RNA binding domain 169 237 3.2E-9 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Pfam PF00575 S1 RNA binding domain 87 153 1.6E-7 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Pfam PF00575 S1 RNA binding domain 341 413 1.2E-16 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Pfam PF00575 S1 RNA binding domain 429 500 1.6E-17 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SUPERFAMILY SSF50249 255 335 4.48E-24 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SUPERFAMILY SSF50249 496 598 2.61E-13 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SUPERFAMILY SSF50249 341 430 3.28E-22 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SUPERFAMILY SSF50249 155 241 4.03E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 90 108 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 356 375 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 221 241 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 108 122 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 278 299 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 150 169 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 396 414 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 174 190 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PRINTS PR00681 Ribosomal protein S1 signature 192 209 3.5E-65 T 21-04-2016 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SUPERFAMILY SSF50249 408 524 5.97E-29 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Gene3D G3DSA:2.40.50.140 428 508 3.1E-27 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PANTHER PTHR10724:SF6 87 576 1.3E-207 T 21-04-2016 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Gene3D G3DSA:2.40.50.140 168 237 1.1E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Gene3D G3DSA:2.40.50.140 509 581 3.2E-11 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Gene3D G3DSA:2.40.50.140 241 329 1.1E-27 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SUPERFAMILY SSF50249 74 178 1.86E-22 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SMART SM00316 341 413 1.7E-23 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SMART SM00316 88 153 9.7E-14 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SMART SM00316 256 326 6.4E-26 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SMART SM00316 169 237 2.1E-8 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SMART SM00316 428 500 1.9E-23 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 SMART SM00316 515 582 1.8E-6 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Gene3D G3DSA:2.40.50.140 343 427 6.2E-26 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 Gene3D G3DSA:2.40.50.140 90 167 3.4E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15605 1d8c23bf2f7a934627fde44c4bb883c6 646 PANTHER PTHR10724 87 576 1.3E-207 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 Gene3D G3DSA:3.30.2090.10 705 795 3.3E-9 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82693 553 649 3.66E-6 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 Gene3D G3DSA:3.30.70.1430 554 649 5.4E-5 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82714 706 790 5.1E-9 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 Gene3D G3DSA:3.30.2090.10 183 261 3.1E-15 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 Gene3D G3DSA:1.10.3850.10 798 1009 4.2E-55 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 Gene3D G3DSA:3.30.70.1430 41 139 3.1E-17 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 PRINTS PR00702 Acriflavin resistance protein family signature 459 482 3.7E-31 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 PRINTS PR00702 Acriflavin resistance protein family signature 38 56 3.7E-31 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 PRINTS PR00702 Acriflavin resistance protein family signature 434 457 3.7E-31 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 PRINTS PR00702 Acriflavin resistance protein family signature 353 374 3.7E-31 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 PRINTS PR00702 Acriflavin resistance protein family signature 10 34 3.7E-31 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 PRINTS PR00702 Acriflavin resistance protein family signature 381 405 3.7E-31 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82693 41 134 1.05E-17 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82866 792 1012 6.8E-45 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 PANTHER PTHR32063 1 1009 5.9E-280 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 Gene3D G3DSA:1.20.1640.10 286 493 2.6E-47 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 Pfam PF00873 AcrB/AcrD/AcrF family 4 1008 9.1E-201 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82714 183 261 3.92E-14 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82693 137 180 8.89E-11 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82693 266 321 8.89E-11 T 21-04-2016 SPH21_RS22845 ed167e5db3529ea0270ba57bc798353c 1014 SUPERFAMILY SSF82866 290 486 3.4E-39 T 21-04-2016 SPH21_RS02915 c8c47597e1b5ede1b1539a55ea73f032 66 Pfam PF08845 Toxin SymE, type I toxin-antitoxin system 25 62 2.7E-13 T 21-04-2016 IPR014944 Toxin SymE-like GO:0003723|GO:0005737|GO:0016070|GO:0016788 SPH21_RS02915 c8c47597e1b5ede1b1539a55ea73f032 66 Gene3D G3DSA:2.10.260.10 37 62 5.1E-7 T 21-04-2016 SPH21_RS06960 454bbceb9a5ccd8908f516d377defd0f 282 Gene3D G3DSA:3.60.21.10 8 146 1.1E-27 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS06960 454bbceb9a5ccd8908f516d377defd0f 282 Gene3D G3DSA:3.60.21.10 188 243 1.1E-27 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS06960 454bbceb9a5ccd8908f516d377defd0f 282 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 7 227 6.2E-13 T 21-04-2016 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type SPH21_RS06960 454bbceb9a5ccd8908f516d377defd0f 282 SUPERFAMILY SSF56300 8 136 2.34E-27 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS06960 454bbceb9a5ccd8908f516d377defd0f 282 SUPERFAMILY SSF56300 169 231 2.34E-27 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS06960 454bbceb9a5ccd8908f516d377defd0f 282 PANTHER PTHR34990:SF2 11 281 3.9E-72 T 21-04-2016 SPH21_RS06960 454bbceb9a5ccd8908f516d377defd0f 282 PANTHER PTHR34990 11 281 3.9E-72 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 SUPERFAMILY SSF49464 26 118 3.92E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 Gene3D G3DSA:2.170.130.10 113 226 2.3E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 PANTHER PTHR11532 1 385 2.8E-236 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 PANTHER PTHR11532 468 1068 2.8E-236 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 Gene3D G3DSA:2.60.40.1120 27 112 1.4E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 SUPERFAMILY SSF56935 882 926 4.03E-80 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 SUPERFAMILY SSF56935 329 419 4.03E-80 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 SUPERFAMILY SSF56935 972 1022 4.03E-80 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 SUPERFAMILY SSF56935 451 800 4.03E-80 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 SUPERFAMILY SSF56935 103 246 4.03E-80 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 1070 3.5E-244 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 Pfam PF07715 TonB-dependent Receptor Plug Domain 117 222 3.2E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 PANTHER PTHR11532:SF57 1 385 2.8E-236 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 PANTHER PTHR11532:SF57 468 1068 2.8E-236 T 21-04-2016 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 198 228 8.6E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02120 d30f27a88f77cde347a143c348905e86 1070 Pfam PF13715 CarboxypepD_reg-like domain 28 109 4.7E-13 T 21-04-2016 SPH21_RS01935 40bb93a6c0fd00c2189473ce00b668ba 318 PANTHER PTHR21624:SF2 89 239 3.8E-12 T 21-04-2016 SPH21_RS01935 40bb93a6c0fd00c2189473ce00b668ba 318 PANTHER PTHR21624 89 239 3.8E-12 T 21-04-2016 SPH21_RS01935 40bb93a6c0fd00c2189473ce00b668ba 318 Pfam PF04116 Fatty acid hydroxylase superfamily 89 239 2.5E-24 T 21-04-2016 IPR006694 Fatty acid hydroxylase GO:0005506|GO:0006633|GO:0016491|GO:0055114 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Pfam PF13715 CarboxypepD_reg-like domain 42 124 1.9E-16 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Gene3D G3DSA:2.40.170.20 359 827 2.7E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Gene3D G3DSA:2.40.170.20 891 917 2.7E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Gene3D G3DSA:2.40.170.20 243 279 2.7E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Gene3D G3DSA:2.40.170.20 950 1043 2.7E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 40 1044 3.8E-213 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Pfam PF07715 TonB-dependent Receptor Plug Domain 132 238 3.2E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 PANTHER PTHR11532:SF57 1 439 7.9E-192 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 PANTHER PTHR11532:SF57 537 1042 7.9E-192 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 PANTHER PTHR11532 1 439 7.9E-192 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 PANTHER PTHR11532 537 1042 7.9E-192 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 SUPERFAMILY SSF56935 882 927 1.6E-72 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 SUPERFAMILY SSF56935 120 262 1.6E-72 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 SUPERFAMILY SSF56935 350 495 1.6E-72 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 SUPERFAMILY SSF56935 960 1043 1.6E-72 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 SUPERFAMILY SSF56935 527 813 1.6E-72 T 21-04-2016 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 214 244 1.8E-13 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 SUPERFAMILY SSF49464 40 122 1.09E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Gene3D G3DSA:2.170.130.10 114 242 1.0E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03150 2e454f1bb9872412c947a950ec583409 1044 Gene3D G3DSA:2.60.40.1120 41 105 2.5E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 PANTHER PTHR31339 167 425 5.3E-138 T 21-04-2016 SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 PANTHER PTHR31339 21 137 5.3E-138 T 21-04-2016 SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 Gene3D G3DSA:2.160.20.10 22 412 7.0E-124 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 ProSitePatterns PS00502 Polygalacturonase active site. 278 292 - T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 Pfam PF12708 Pectate lyase superfamily protein 23 78 7.0E-13 T 21-04-2016 IPR024535 Pectate lyase superfamily protein SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 PANTHER PTHR31339:SF0 167 425 5.3E-138 T 21-04-2016 SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 PANTHER PTHR31339:SF0 21 137 5.3E-138 T 21-04-2016 SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 Pfam PF00295 Glycosyl hydrolases family 28 179 404 4.2E-45 T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 SUPERFAMILY SSF51126 3 400 6.29E-111 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 SMART SM00710 298 319 3.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 SMART SM00710 413 435 3700.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 SMART SM00710 237 258 2.7 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 SMART SM00710 271 292 45.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 SMART SM00710 327 349 6900.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS11345 136307e3f382ccf5e33f133029736401 517 SMART SM00710 211 236 74.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 PANTHER PTHR10285 2 186 6.6E-43 T 21-04-2016 SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 PRINTS PR00988 Uridine kinase signature 5 22 3.2E-13 T 21-04-2016 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193|UniPathway: UPA00574|UniPathway: UPA00579 SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 PRINTS PR00988 Uridine kinase signature 172 185 3.2E-13 T 21-04-2016 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193|UniPathway: UPA00574|UniPathway: UPA00579 SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 PRINTS PR00988 Uridine kinase signature 136 146 3.2E-13 T 21-04-2016 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193|UniPathway: UPA00574|UniPathway: UPA00579 SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 PRINTS PR00988 Uridine kinase signature 35 46 3.2E-13 T 21-04-2016 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193|UniPathway: UPA00574|UniPathway: UPA00579 SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 Gene3D G3DSA:3.40.50.300 4 203 9.2E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 Pfam PF00485 Phosphoribulokinase / Uridine kinase family 7 187 3.0E-32 T 21-04-2016 IPR006083 Phosphoribulokinase/uridine kinase GO:0005524|GO:0008152|GO:0016301 SPH21_RS23005 ee4413488449f2378c81c41d9feb8e93 210 SUPERFAMILY SSF52540 3 195 3.16E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 ProSitePatterns PS00321 recA signature. 214 222 - T 21-04-2016 IPR020584 DNA recombination/repair protein RecA, conserved site GO:0003677|GO:0005524|GO:0006259|GO:0008094 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 Gene3D G3DSA:3.30.250.10 269 327 7.4E-26 T 21-04-2016 IPR023400 DNA recombination and repair protein RecA, C-terminal SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 SUPERFAMILY SSF52540 8 268 5.6E-67 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 Hamap MF_00268 Protein RecA [recA]. 6 330 51.454 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PANTHER PTHR22942 6 336 1.6E-197 T 21-04-2016 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 SMART SM00382 58 229 2.4E-12 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 SUPERFAMILY SSF54752 269 326 3.14E-20 T 21-04-2016 IPR023400 DNA recombination and repair protein RecA, C-terminal SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 Gene3D G3DSA:3.40.50.300 29 268 2.4E-82 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 TIGRFAM TIGR02012 tigrfam_recA: protein RecA 5 325 5.9E-173 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PANTHER PTHR22942:SF1 6 336 1.6E-197 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 Pfam PF00154 recA bacterial DNA recombination protein 8 269 2.1E-141 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PRINTS PR00142 RecA protein signature 94 123 3.4E-82 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PRINTS PR00142 RecA protein signature 244 273 3.4E-82 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PRINTS PR00142 RecA protein signature 166 195 3.4E-82 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PRINTS PR00142 RecA protein signature 211 239 3.4E-82 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PRINTS PR00142 RecA protein signature 128 157 3.4E-82 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS02810 ec422e650640ecbe8704c7a1a2b3e1c4 338 PRINTS PR00142 RecA protein signature 298 315 3.4E-82 T 21-04-2016 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SPH21_RS17820 1dd9aab2d5a076ed3b8f0e8295a74142 134 Pfam PF11888 Protein of unknown function (DUF3408) 14 129 9.2E-31 T 21-04-2016 IPR021823 Protein of unknown function DUF3408 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 43 62 3.7E-11 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 282 291 3.7E-11 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 294 317 3.7E-11 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PANTHER PTHR11405:SF1 11 331 2.3E-56 T 21-04-2016 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PRINTS PR00101 Aspartate carbamoyltransferase signature 146 163 3.3E-6 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PRINTS PR00101 Aspartate carbamoyltransferase signature 33 55 3.3E-6 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PRINTS PR00101 Aspartate carbamoyltransferase signature 286 291 3.3E-6 T 21-04-2016 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 PANTHER PTHR11405 11 331 2.3E-56 T 21-04-2016 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 SUPERFAMILY SSF53671 2 331 2.23E-52 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 Gene3D G3DSA:3.40.50.1370 1 158 1.5E-42 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 3 160 2.4E-23 T 21-04-2016 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 Gene3D G3DSA:3.40.50.1370 159 316 8.8E-36 T 21-04-2016 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SPH21_RS05100 603a56b4db5c0f89acac5b669e75a2c1 332 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 214 325 6.0E-18 T 21-04-2016 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 SPH21_RS03180 6791c331afc21310257ac90f4fc2dc91 904 SUPERFAMILY SSF56935 681 809 7.33E-12 T 21-04-2016 SPH21_RS03180 6791c331afc21310257ac90f4fc2dc91 904 Gene3D G3DSA:2.60.40.1120 561 659 5.0E-8 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03180 6791c331afc21310257ac90f4fc2dc91 904 SUPERFAMILY SSF49464 561 607 1.65E-6 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03180 6791c331afc21310257ac90f4fc2dc91 904 Gene3D G3DSA:2.170.130.10 678 804 2.2E-5 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03180 6791c331afc21310257ac90f4fc2dc91 904 Pfam PF07715 TonB-dependent Receptor Plug Domain 743 795 3.8E-5 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03180 6791c331afc21310257ac90f4fc2dc91 904 Pfam PF13620 Carboxypeptidase regulatory-like domain 561 618 8.2E-8 T 21-04-2016 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 Gene3D G3DSA:3.20.20.70 4 296 5.0E-59 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 PANTHER PTHR32332 2 83 1.9E-96 T 21-04-2016 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 PANTHER PTHR32332 114 355 1.9E-96 T 21-04-2016 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 Pfam PF03060 Nitronate monooxygenase 5 352 5.2E-71 T 21-04-2016 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 PANTHER PTHR32332:SF12 2 83 1.9E-96 T 21-04-2016 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 PANTHER PTHR32332:SF12 114 355 1.9E-96 T 21-04-2016 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 SUPERFAMILY SSF51412 4 76 1.13E-56 T 21-04-2016 SPH21_RS20650 a412741cd6cd6a6e6c7f3d16345cee46 358 SUPERFAMILY SSF51412 107 349 1.13E-56 T 21-04-2016 SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 SUPERFAMILY SSF55920 3 247 4.19E-62 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 Gene3D G3DSA:3.90.230.10 5 249 3.1E-67 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 Hamap MF_01974 Methionine aminopeptidase [map]. 1 249 31.74 T 21-04-2016 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 PANTHER PTHR10804:SF41 1 250 1.7E-76 T 21-04-2016 SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 PANTHER PTHR10804 1 250 1.7E-76 T 21-04-2016 SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 1 248 2.3E-77 T 21-04-2016 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 159 171 6.2E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 66 79 6.2E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 191 203 6.2E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 89 105 6.2E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS22755 840832b58eaa6c284d0d4eb17a544237 254 Pfam PF00557 Metallopeptidase family M24 12 240 6.6E-40 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 PANTHER PTHR11532:SF57 418 446 9.3E-278 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 PANTHER PTHR11532:SF57 24 361 9.3E-278 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 29 1035 9.7E-287 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 Pfam PF07715 TonB-dependent Receptor Plug Domain 118 225 5.3E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 SUPERFAMILY SSF49464 28 108 2.35E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 SUPERFAMILY SSF56935 106 249 9.61E-87 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 SUPERFAMILY SSF56935 307 395 9.61E-87 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 SUPERFAMILY SSF56935 428 799 9.61E-87 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 SUPERFAMILY SSF56935 950 1035 9.61E-87 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 SUPERFAMILY SSF56935 868 911 9.61E-87 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 201 231 2.2E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 PANTHER PTHR11532:SF57 509 1033 9.3E-278 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 PANTHER PTHR11532 418 446 9.3E-278 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 PANTHER PTHR11532 24 361 9.3E-278 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 PANTHER PTHR11532 509 1033 9.3E-278 T 21-04-2016 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 Gene3D G3DSA:2.60.40.1120 29 113 5.4E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 Gene3D G3DSA:2.170.130.10 114 228 7.6E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09525 f41a6441f4eb5362f88acb9d2fd79399 1035 Pfam PF13715 CarboxypepD_reg-like domain 29 110 7.8E-14 T 21-04-2016 SPH21_RS05865 e0898d945000d4e329de5dfebdd21530 361 PANTHER PTHR11601:SF31 7 361 8.7E-35 T 21-04-2016 SPH21_RS05865 e0898d945000d4e329de5dfebdd21530 361 Gene3D G3DSA:3.40.640.10 38 259 1.5E-28 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS05865 e0898d945000d4e329de5dfebdd21530 361 Pfam PF00266 Aminotransferase class-V 19 347 1.9E-18 T 21-04-2016 IPR000192 Aminotransferase class V domain SPH21_RS05865 e0898d945000d4e329de5dfebdd21530 361 Gene3D G3DSA:3.90.1150.10 260 359 2.8E-9 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS05865 e0898d945000d4e329de5dfebdd21530 361 SUPERFAMILY SSF53383 16 360 8.06E-45 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS05865 e0898d945000d4e329de5dfebdd21530 361 PANTHER PTHR11601 7 361 8.7E-35 T 21-04-2016 SPH21_RS26105 129f94bbf76750244c274adbf37bb65c 448 Pfam PF14903 WG containing repeat 402 433 6.1E-11 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS26105 129f94bbf76750244c274adbf37bb65c 448 Pfam PF14903 WG containing repeat 300 333 0.042 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS26105 129f94bbf76750244c274adbf37bb65c 448 Pfam PF14903 WG containing repeat 368 401 3.4E-4 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS26105 129f94bbf76750244c274adbf37bb65c 448 Pfam PF14903 WG containing repeat 334 368 1.7E-4 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS26105 129f94bbf76750244c274adbf37bb65c 448 SUPERFAMILY SSF69360 304 422 2.75E-5 T 21-04-2016 SPH21_RS26105 129f94bbf76750244c274adbf37bb65c 448 PANTHER PTHR37841 142 446 1.5E-15 T 21-04-2016 SPH21_RS16360 a73cf7346e38933222e9721e8ac8c32c 542 Pfam PF01039 Carboxyl transferase domain 37 531 8.0E-146 T 21-04-2016 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|UniPathway: UPA00655 SPH21_RS16360 a73cf7346e38933222e9721e8ac8c32c 542 Gene3D G3DSA:3.90.226.10 18 259 5.5E-66 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS16360 a73cf7346e38933222e9721e8ac8c32c 542 Gene3D G3DSA:3.90.226.10 274 532 1.0E-84 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS16360 a73cf7346e38933222e9721e8ac8c32c 542 SUPERFAMILY SSF52096 17 258 3.64E-60 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS16360 a73cf7346e38933222e9721e8ac8c32c 542 PANTHER PTHR22855 4 542 8.6E-262 T 21-04-2016 SPH21_RS16360 a73cf7346e38933222e9721e8ac8c32c 542 PANTHER PTHR22855:SF13 4 542 8.6E-262 T 21-04-2016 SPH21_RS16360 a73cf7346e38933222e9721e8ac8c32c 542 SUPERFAMILY SSF52096 272 532 1.81E-78 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 Gene3D G3DSA:2.40.50.140 6 83 7.0E-37 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 SUPERFAMILY SSF50249 6 83 1.5E-33 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 ProDom PD001295 RIBOSOMAL S17 30S RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 40S S11 S17P S11 7 77 1.0E-25 T 21-04-2016 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 ProSitePatterns PS00056 Ribosomal protein S17 signature. 57 69 - T 21-04-2016 IPR019979 Ribosomal protein S17, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 PANTHER PTHR10744 6 83 1.1E-41 T 21-04-2016 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 TIGRFAM TIGR03635 uS17_bact: ribosomal protein uS17 6 77 8.6E-38 T 21-04-2016 IPR019984 Ribosomal protein S17, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 Pfam PF00366 Ribosomal protein S17 11 78 2.7E-33 T 21-04-2016 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 PRINTS PR00973 Ribosomal protein S17 family signature 57 67 5.2E-14 T 21-04-2016 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 PRINTS PR00973 Ribosomal protein S17 family signature 67 74 5.2E-14 T 21-04-2016 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 PRINTS PR00973 Ribosomal protein S17 family signature 25 48 5.2E-14 T 21-04-2016 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08540 e6b08dec9bcf700465c87050222d47a0 84 Hamap MF_01345_B 30S ribosomal protein S17 [rpsQ]. 4 82 26.835 T 21-04-2016 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 SUPERFAMILY SSF55103 226 464 3.11E-60 T 21-04-2016 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 SUPERFAMILY SSF56176 8 220 4.67E-68 T 21-04-2016 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 Gene3D G3DSA:3.30.43.10 4 98 2.6E-28 T 21-04-2016 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 Pfam PF02913 FAD linked oxidases, C-terminal domain 220 463 4.4E-61 T 21-04-2016 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 Pfam PF01565 FAD binding domain 44 183 8.3E-41 T 21-04-2016 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 Gene3D G3DSA:3.30.465.10 99 220 7.4E-37 T 21-04-2016 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 PANTHER PTHR11748 3 464 1.1E-140 T 21-04-2016 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 Gene3D G3DSA:1.10.45.10 424 463 5.4E-13 T 21-04-2016 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 SPH21_RS08655 7d4081da378b692e743154de0c0d2fb9 464 PANTHER PTHR11748:SF35 3 464 1.1E-140 T 21-04-2016 SPH21_RS17950 1856607d6f7e8796ef6e30aee1125c4b 192 Pfam PF08534 Redoxin 52 182 2.5E-18 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS17950 1856607d6f7e8796ef6e30aee1125c4b 192 SUPERFAMILY SSF52833 55 189 3.57E-35 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17950 1856607d6f7e8796ef6e30aee1125c4b 192 PANTHER PTHR10681 56 172 1.2E-20 T 21-04-2016 SPH21_RS17950 1856607d6f7e8796ef6e30aee1125c4b 192 PANTHER PTHR10681:SF125 56 172 1.2E-20 T 21-04-2016 SPH21_RS17950 1856607d6f7e8796ef6e30aee1125c4b 192 Gene3D G3DSA:3.40.30.10 11 190 3.4E-44 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 PANTHER PTHR21327 1 400 5.6E-233 T 21-04-2016 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 PIRSF PIRSF001259 4 404 7.1E-183 T 21-04-2016 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 TIGRFAM TIGR00505 ribA: GTP cyclohydrolase II 214 400 1.8E-75 T 21-04-2016 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|UniPathway: UPA00275 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 Pfam PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase 9 201 3.5E-84 T 21-04-2016 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 Hamap MF_01283 Riboflavin biosynthesis protein RibBA [ribBA]. 4 398 54.118 T 21-04-2016 IPR016299 Riboflavin biosynthesis protein RibBA GO:0009231 KEGG: 00740+3.5.4.25+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168|MetaCyc: PWY-7539|UniPathway: UPA00275|UniPathway: UPA00275 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 SUPERFAMILY SSF142695 208 378 1.31E-72 T 21-04-2016 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|UniPathway: UPA00275 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 PANTHER PTHR21327:SF6 1 400 5.6E-233 T 21-04-2016 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 Hamap MF_00180 3,4-dihydroxy-2-butanone 4-phosphate synthase [ribB]. 3 206 37.539 T 21-04-2016 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 TIGRFAM TIGR00506 ribB: 3,4-dihydroxy-2-butanone-4-phosphate synthase 5 202 1.5E-76 T 21-04-2016 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 Hamap MF_00179 GTP cyclohydrolase-2 [ribA]. 207 402 39.984 T 21-04-2016 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|UniPathway: UPA00275 SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 Gene3D G3DSA:3.90.870.10 3 212 1.2E-97 T 21-04-2016 IPR017945 DHBP synthase RibB-like alpha/beta domain SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 SUPERFAMILY SSF55821 6 208 5.26E-85 T 21-04-2016 IPR017945 DHBP synthase RibB-like alpha/beta domain SPH21_RS02790 0cf5c1f25e3bfddd88069cfc7ec173e8 404 Pfam PF00925 GTP cyclohydrolase II 212 375 1.0E-73 T 21-04-2016 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539|UniPathway: UPA00275 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 SMART SM00342 214 297 1.9E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 PANTHER PTHR11019 68 301 7.0E-20 T 21-04-2016 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 SUPERFAMILY SSF46689 252 298 2.2E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 SUPERFAMILY SSF51215 48 170 3.4E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 Gene3D G3DSA:1.10.10.60 252 298 8.9E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 PANTHER PTHR11019:SF80 68 301 7.0E-20 T 21-04-2016 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 Pfam PF12833 Helix-turn-helix domain 221 298 1.1E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 281 297 4.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS21765 d28878cd3b52911e5d3839fd0f3fa2c1 302 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 266 281 4.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Gene3D G3DSA:2.40.170.20 909 1008 3.4E-65 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Gene3D G3DSA:2.40.170.20 424 791 3.4E-65 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Gene3D G3DSA:2.40.170.20 236 260 3.4E-65 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Gene3D G3DSA:2.40.170.20 848 873 3.4E-65 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Gene3D G3DSA:2.40.170.20 307 388 3.4E-65 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 SUPERFAMILY SSF56935 839 883 8.42E-111 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 SUPERFAMILY SSF56935 430 773 8.42E-111 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 SUPERFAMILY SSF56935 106 256 8.42E-111 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 SUPERFAMILY SSF56935 298 386 8.42E-111 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 SUPERFAMILY SSF56935 918 1008 8.42E-111 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 1008 1.7E-264 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 PANTHER PTHR11532:SF57 1 352 4.9E-264 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 PANTHER PTHR11532:SF57 469 534 4.9E-264 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 PANTHER PTHR11532:SF57 563 1006 4.9E-264 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Gene3D G3DSA:2.60.40.1120 25 116 6.3E-18 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 PANTHER PTHR11532 1 352 4.9E-264 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 PANTHER PTHR11532 469 534 4.9E-264 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 PANTHER PTHR11532 563 1006 4.9E-264 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Pfam PF00593 TonB dependent receptor 607 1007 1.5E-27 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Pfam PF07715 TonB-dependent Receptor Plug Domain 117 232 2.5E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Pfam PF13715 CarboxypepD_reg-like domain 26 109 6.0E-20 T 21-04-2016 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 SUPERFAMILY SSF49464 25 118 2.62E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 208 238 5.6E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09825 11cfef1ec0b7237e7558e9d1139ea1cb 1008 Gene3D G3DSA:2.170.130.10 117 235 1.6E-25 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 PRINTS PR00171 Sugar transporter signature 365 386 3.3E-18 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 PRINTS PR00171 Sugar transporter signature 276 286 3.3E-18 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 PRINTS PR00171 Sugar transporter signature 21 31 3.3E-18 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 PRINTS PR00171 Sugar transporter signature 104 123 3.3E-18 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 PRINTS PR00171 Sugar transporter signature 388 400 3.3E-18 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 ProSitePatterns PS00216 Sugar transport proteins signature 1. 320 336 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 ProSitePatterns PS00216 Sugar transport proteins signature 1. 67 84 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 Pfam PF00083 Sugar (and other) transporter 14 464 5.6E-107 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 Gene3D G3DSA:1.20.1250.20 16 214 3.5E-25 T 21-04-2016 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 Gene3D G3DSA:1.20.1250.20 266 459 3.2E-21 T 21-04-2016 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 2 460 4.9E-102 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 ProSitePatterns PS00217 Sugar transport proteins signature 2. 109 134 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 SUPERFAMILY SSF103473 15 461 3.01E-70 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 PANTHER PTHR23500 184 464 7.6E-151 T 21-04-2016 SPH21_RS00550 0691eafb66080e915b8db95c5cc62a3a 466 PANTHER PTHR23500 13 166 7.6E-151 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 416 508 3.8E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 789 901 5.2E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 31 67 8.6E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 99 194 8.6E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 PANTHER PTHR23083 638 695 1.4E-19 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 PANTHER PTHR23083 736 857 1.4E-19 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 PANTHER PTHR23083 896 986 1.4E-19 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 PANTHER PTHR23083 158 412 1.4E-19 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 553 589 2.98E-11 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 256 359 2.98E-11 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 642 697 2.98E-11 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 812 986 1.96E-8 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SMART SM00028 255 288 49.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SMART SM00028 113 143 160.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SMART SM00028 553 586 32.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SMART SM00028 150 183 77.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SMART SM00028 920 953 52.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SMART SM00028 662 695 4.6 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SMART SM00028 958 991 190.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 739 834 2.78E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 123 176 7.0E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 308 415 1.2E-12 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 902 987 3.0E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 296 424 3.98E-12 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Pfam PF13432 Tetratricopeptide repeat 94 139 4.6E-4 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Pfam PF13432 Tetratricopeptide repeat 742 795 2.8E-4 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Pfam PF13432 Tetratricopeptide repeat 296 356 0.0065 T 21-04-2016 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 736 788 1.1E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 27 122 2.4E-8 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 203 307 2.4E-8 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Gene3D G3DSA:1.25.40.10 529 702 1.1E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 SUPERFAMILY SSF48452 475 602 3.48E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Pfam PF13174 Tetratricopeptide repeat 963 988 0.075 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS10970 e39fdab0d37ae98f1d44872705e76c8b 1004 Pfam PF13525 Outer membrane lipoprotein 608 707 6.1E-8 T 21-04-2016 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PANTHER PTHR10836:SF50 1 334 5.3E-178 T 21-04-2016 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 268 283 4.5E-34 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 108 121 4.5E-34 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 172 188 4.5E-34 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 145 163 4.5E-34 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 228 245 4.5E-34 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PIRSF PIRSF000149 1 333 5.2E-122 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 1 151 4.4E-57 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 Gene3D G3DSA:3.40.50.720 1 158 7.7E-67 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 156 311 3.3E-57 T 21-04-2016 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 SUPERFAMILY SSF55347 151 312 1.01E-63 T 21-04-2016 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 SMART SM00846 1 151 3.3E-81 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 SUPERFAMILY SSF51735 2 167 5.2E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 TIGRFAM TIGR01534 GAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I 2 323 2.5E-125 T 21-04-2016 IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I GO:0006006|GO:0016620|GO:0050661|GO:0051287|GO:0055114 KEGG: 00010+1.2.1.12|KEGG: 00710+1.2.1.12|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 PANTHER PTHR10836 1 334 5.3E-178 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS00335 159d69b2c77c9f66e7f7b544cf27366e 334 Gene3D G3DSA:3.30.360.10 159 313 4.4E-64 T 21-04-2016 SPH21_RS18695 f5ac938642171cc4bfc24f9a51006414 479 Gene3D G3DSA:3.90.480.10 2 48 8.8E-4 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS18695 f5ac938642171cc4bfc24f9a51006414 479 SUPERFAMILY SSF57802 429 478 3.53E-11 T 21-04-2016 SPH21_RS18695 f5ac938642171cc4bfc24f9a51006414 479 Gene3D G3DSA:2.20.28.10 428 478 3.0E-14 T 21-04-2016 IPR004039 Rubredoxin-type fold SPH21_RS18695 f5ac938642171cc4bfc24f9a51006414 479 Pfam PF00301 Rubredoxin 431 475 2.7E-12 T 21-04-2016 IPR024935 Rubredoxin domain GO:0005506 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 Gene3D G3DSA:3.40.190.120 237 315 6.4E-22 T 21-04-2016 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 Gene3D G3DSA:1.10.3720.10 11 203 1.3E-31 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 SUPERFAMILY SSF161098 19 204 2.07E-38 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 PANTHER PTHR30177 2 377 8.2E-132 T 21-04-2016 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 SUPERFAMILY SSF53850 236 377 1.95E-31 T 21-04-2016 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 41 209 3.2E-23 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 PANTHER PTHR30177:SF4 2 377 8.2E-132 T 21-04-2016 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 Gene3D G3DSA:3.40.190.10 383 507 5.2E-39 T 21-04-2016 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 Gene3D G3DSA:3.40.190.10 321 376 1.4E-14 T 21-04-2016 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 387 519 9.2E-24 T 21-04-2016 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 240 373 8.3E-29 T 21-04-2016 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SPH21_RS12730 368b29634d2763ee50591f14ac5b4fa2 523 SUPERFAMILY SSF53850 386 519 8.68E-25 T 21-04-2016 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 SUPERFAMILY SSF51735 2 148 5.68E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 Gene3D G3DSA:1.10.1740.10 301 383 1.9E-27 T 21-04-2016 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 Pfam PF08436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal 144 227 5.6E-39 T 21-04-2016 IPR013644 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal GO:0005515 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 PIRSF PIRSF006205 1 387 2.9E-153 T 21-04-2016 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 Pfam PF13288 DXP reductoisomerase C-terminal domain 259 375 4.9E-38 T 21-04-2016 IPR026877 DXP reductoisomerase C-terminal domain KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 Pfam PF02670 1-deoxy-D-xylulose 5-phosphate reductoisomerase 4 130 6.1E-40 T 21-04-2016 IPR013512 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal GO:0055114|GO:0070402 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 Gene3D G3DSA:3.40.50.720 1 148 5.4E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 TIGRFAM TIGR00243 Dxr: 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1 381 8.3E-140 T 21-04-2016 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 SUPERFAMILY SSF69055 290 382 6.93E-28 T 21-04-2016 IPR026877 DXP reductoisomerase C-terminal domain KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 Hamap MF_00183 1-deoxy-D-xylulose 5-phosphate reductoisomerase [dxr]. 4 380 45.455 T 21-04-2016 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 PANTHER PTHR30525 1 391 2.8E-201 T 21-04-2016 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14520 8681bc6a4c7397e0f490f7d55daa4d9f 392 SUPERFAMILY SSF55347 124 262 4.25E-59 T 21-04-2016 SPH21_RS25845 e85edd7a1fc9bb76d0dd64416d4be21b 374 Gene3D G3DSA:1.20.1250.20 2 173 3.3E-21 T 21-04-2016 SPH21_RS25845 e85edd7a1fc9bb76d0dd64416d4be21b 374 PANTHER PTHR23501:SF79 1 369 2.1E-103 T 21-04-2016 SPH21_RS25845 e85edd7a1fc9bb76d0dd64416d4be21b 374 PANTHER PTHR23501 1 369 2.1E-103 T 21-04-2016 SPH21_RS25845 e85edd7a1fc9bb76d0dd64416d4be21b 374 Gene3D G3DSA:1.20.1250.20 198 368 5.4E-11 T 21-04-2016 SPH21_RS25845 e85edd7a1fc9bb76d0dd64416d4be21b 374 SUPERFAMILY SSF103473 2 369 7.59E-44 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS25845 e85edd7a1fc9bb76d0dd64416d4be21b 374 Pfam PF07690 Major Facilitator Superfamily 6 254 7.7E-25 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS25450 ec6c8d5cd092c3d686c1a3f434c041bd 695 Pfam PF07715 TonB-dependent Receptor Plug Domain 51 155 1.7E-14 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25450 ec6c8d5cd092c3d686c1a3f434c041bd 695 PANTHER PTHR32552 7 695 6.8E-31 T 21-04-2016 SPH21_RS25450 ec6c8d5cd092c3d686c1a3f434c041bd 695 SUPERFAMILY SSF56935 32 694 8.42E-88 T 21-04-2016 SPH21_RS25450 ec6c8d5cd092c3d686c1a3f434c041bd 695 Gene3D G3DSA:2.40.170.20 157 694 2.7E-66 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25450 ec6c8d5cd092c3d686c1a3f434c041bd 695 Gene3D G3DSA:2.170.130.10 38 156 7.7E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25450 ec6c8d5cd092c3d686c1a3f434c041bd 695 Pfam PF00593 TonB dependent receptor 438 694 1.9E-28 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 PANTHER PTHR21180 137 304 7.5E-16 T 21-04-2016 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 Gene3D G3DSA:1.10.150.310 183 249 1.6E-12 T 21-04-2016 IPR023097 Tex RuvX-like domain SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 SUPERFAMILY SSF47781 69 141 8.0E-8 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 PANTHER PTHR21180:SF32 137 304 7.5E-16 T 21-04-2016 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 SUPERFAMILY SSF47781 169 236 1.67E-15 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 Pfam PF12836 Helix-hairpin-helix motif 242 301 6.0E-16 T 21-04-2016 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 Pfam PF12836 Helix-hairpin-helix motif 175 233 4.0E-14 T 21-04-2016 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 SUPERFAMILY SSF47781 237 304 1.33E-15 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 Gene3D G3DSA:1.10.150.320 250 301 1.7E-10 T 21-04-2016 SPH21_RS11065 0c1af54aa7afa6e5d68e047de076e7de 305 Gene3D G3DSA:1.10.150.320 110 144 9.3E-4 T 21-04-2016 SPH21_RS18850 836f8d9beca418ed4bf90670016a8449 331 Gene3D G3DSA:3.30.470.20 125 327 1.0E-4 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS18850 836f8d9beca418ed4bf90670016a8449 331 SUPERFAMILY SSF56059 136 325 6.33E-19 T 21-04-2016 SPH21_RS09050 e8be0e8e1b4d4b080b1ea5b2f9563f88 388 SUPERFAMILY SSF53756 75 365 8.9E-29 T 21-04-2016 SPH21_RS09050 e8be0e8e1b4d4b080b1ea5b2f9563f88 388 Pfam PF00534 Glycosyl transferases group 1 211 356 4.4E-10 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS09050 e8be0e8e1b4d4b080b1ea5b2f9563f88 388 Gene3D G3DSA:3.40.50.2000 213 293 2.6E-4 T 21-04-2016 SPH21_RS19955 83e7fdb52423b7c9ec51f2a65b8e7173 161 TIGRFAM TIGR01498 folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 4 132 3.7E-39 T 21-04-2016 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS19955 83e7fdb52423b7c9ec51f2a65b8e7173 161 PANTHER PTHR20941 1 151 8.7E-56 T 21-04-2016 SPH21_RS19955 83e7fdb52423b7c9ec51f2a65b8e7173 161 Pfam PF01288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) 5 132 1.6E-34 T 21-04-2016 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS19955 83e7fdb52423b7c9ec51f2a65b8e7173 161 SUPERFAMILY SSF55083 1 153 1.22E-46 T 21-04-2016 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS19955 83e7fdb52423b7c9ec51f2a65b8e7173 161 Gene3D G3DSA:3.30.70.560 2 153 2.8E-48 T 21-04-2016 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS21400 89fbcecf60d7a6b1354296500b2a0191 190 Gene3D G3DSA:1.10.357.10 8 170 1.1E-19 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS21400 89fbcecf60d7a6b1354296500b2a0191 190 SUPERFAMILY SSF46689 3 71 2.44E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21400 89fbcecf60d7a6b1354296500b2a0191 190 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 1.1E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 Gene3D G3DSA:1.10.287.130 324 378 1.6E-6 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 PANTHER PTHR24423 323 545 1.2E-54 T 21-04-2016 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 PANTHER PTHR24423 144 160 1.2E-54 T 21-04-2016 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 Pfam PF00512 His Kinase A (phospho-acceptor) domain 328 391 6.3E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 SUPERFAMILY SSF55874 381 545 6.16E-37 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 SUPERFAMILY SSF47384 321 392 4.51E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 SMART SM00387 435 547 2.8E-25 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 SMART SM00388 325 392 3.8E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 PRINTS PR00344 Bacterial sensor protein C-terminal signature 531 544 5.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 PRINTS PR00344 Bacterial sensor protein C-terminal signature 473 487 5.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 PRINTS PR00344 Bacterial sensor protein C-terminal signature 507 525 5.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 PRINTS PR00344 Bacterial sensor protein C-terminal signature 491 501 5.5E-13 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 Gene3D G3DSA:3.30.565.10 379 545 2.0E-39 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07765 dd2ed7c0d433074ade34d0e5260d7ce4 547 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 436 545 1.5E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 PIRSF PIRSF001092 1 458 1.3E-125 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 Pfam PF01120 Alpha-L-fucosidase 32 357 6.4E-96 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 SUPERFAMILY SSF51445 38 361 8.0E-103 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 PRINTS PR00741 Glycosyl hydrolase family 29 signature 344 366 3.42E-17 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 PRINTS PR00741 Glycosyl hydrolase family 29 signature 108 124 3.42E-17 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 PRINTS PR00741 Glycosyl hydrolase family 29 signature 311 332 3.42E-17 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 PANTHER PTHR10030 43 362 9.6E-73 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 SMART SM00812 27 404 1.9E-117 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS03000 b63cb25abb2a23c62a3b475c4dfe49a1 464 Gene3D G3DSA:3.20.20.80 33 361 1.9E-103 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.30.1950.10 169 237 8.6E-14 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Pfam PF10531 SLBB domain 503 553 2.1E-12 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Pfam PF10531 SLBB domain 412 448 8.4E-6 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Pfam PF10531 SLBB domain 247 295 5.7E-9 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Pfam PF10531 SLBB domain 599 645 3.7E-5 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Pfam PF10531 SLBB domain 330 374 6.2E-11 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Pfam PF06251 Capsule biosynthesis GfcC 726 808 3.4E-5 T 21-04-2016 IPR010425 Domain of unknown function DUF1017 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Pfam PF02563 Polysaccharide biosynthesis/export protein 161 237 5.7E-17 T 21-04-2016 IPR003715 Polysaccharide export protein GO:0015159|GO:0015774|GO:0016020 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 PANTHER PTHR33619 557 784 1.2E-100 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 PANTHER PTHR33619 133 535 1.2E-100 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.10.560.10 406 492 3.4E-16 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.10.560.10 328 387 6.4E-12 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.10.560.10 698 729 4.8E-16 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.10.560.10 730 807 6.1E-7 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.10.560.10 238 324 3.2E-17 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.10.560.10 597 645 4.8E-16 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 Gene3D G3DSA:3.10.560.10 499 589 8.9E-15 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 PANTHER PTHR33619:SF1 557 784 1.2E-100 T 21-04-2016 SPH21_RS08875 1e6da3a3ff73c1ee3c7a1b39d87ce163 840 PANTHER PTHR33619:SF1 133 535 1.2E-100 T 21-04-2016 SPH21_RS24915 e1daaf518edd5be8a9a843057f50fb82 492 Pfam PF14322 Starch-binding associating with outer membrane 25 220 1.3E-21 T 21-04-2016 SPH21_RS24915 e1daaf518edd5be8a9a843057f50fb82 492 Pfam PF07980 SusD family 348 491 5.3E-35 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS24915 e1daaf518edd5be8a9a843057f50fb82 492 SUPERFAMILY SSF48452 19 491 3.67E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24915 e1daaf518edd5be8a9a843057f50fb82 492 Gene3D G3DSA:1.25.40.10 201 435 8.0E-36 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14735 ad7a07a29d7d31a54ca1b2fa896b2e5f 308 Pfam PF03737 Demethylmenaquinone methyltransferase 75 231 4.8E-15 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS14735 ad7a07a29d7d31a54ca1b2fa896b2e5f 308 SUPERFAMILY SSF89562 75 240 1.27E-21 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS14735 ad7a07a29d7d31a54ca1b2fa896b2e5f 308 Gene3D G3DSA:3.50.30.40 76 241 3.2E-29 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS08560 a31e040f580e8be24879e2ac9ef8a416 89 PANTHER PTHR19836 1 89 1.3E-47 T 21-04-2016 IPR001209 Ribosomal protein S14 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08560 a31e040f580e8be24879e2ac9ef8a416 89 SUPERFAMILY SSF57716 2 89 9.27E-32 T 21-04-2016 SPH21_RS08560 a31e040f580e8be24879e2ac9ef8a416 89 Pfam PF00253 Ribosomal protein S14p/S29e 36 88 1.5E-27 T 21-04-2016 IPR001209 Ribosomal protein S14 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08560 a31e040f580e8be24879e2ac9ef8a416 89 PANTHER PTHR19836:SF20 1 89 1.3E-47 T 21-04-2016 SPH21_RS08560 a31e040f580e8be24879e2ac9ef8a416 89 Hamap MF_00537 30S ribosomal protein S14 [rpsN]. 1 89 24.602 T 21-04-2016 IPR023036 Ribosomal protein S14, bacterial/plastid SPH21_RS08560 a31e040f580e8be24879e2ac9ef8a416 89 Gene3D G3DSA:4.10.830.10 35 89 1.1E-29 T 21-04-2016 SPH21_RS08560 a31e040f580e8be24879e2ac9ef8a416 89 ProSitePatterns PS00527 Ribosomal protein S14 signature. 51 73 - T 21-04-2016 IPR018271 Ribosomal protein S14, conserved site GO:0003735|GO:0005840|GO:0006412 SPH21_RS12655 db492485f61d9a69775cde384f1ea75d 267 Pfam PF02311 AraC-like ligand binding domain 14 68 1.9E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS12655 db492485f61d9a69775cde384f1ea75d 267 Gene3D G3DSA:2.60.120.280 12 88 3.2E-9 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS12655 db492485f61d9a69775cde384f1ea75d 267 Gene3D G3DSA:1.10.10.60 167 225 3.9E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12655 db492485f61d9a69775cde384f1ea75d 267 SUPERFAMILY SSF51215 11 80 1.31E-8 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 Gene3D G3DSA:3.20.20.80 332 629 2.7E-37 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 30 206 9.4E-9 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 SUPERFAMILY SSF51445 325 638 3.2E-50 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 PANTHER PTHR10066 28 82 2.2E-41 T 21-04-2016 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 PANTHER PTHR10066 206 497 2.2E-41 T 21-04-2016 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 PANTHER PTHR10066 115 190 2.2E-41 T 21-04-2016 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 Pfam PF00703 Glycosyl hydrolases family 2 225 328 2.4E-8 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 Gene3D G3DSA:2.60.120.260 6 212 7.7E-27 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 Gene3D G3DSA:2.60.40.320 213 329 5.6E-7 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 330 483 3.5E-6 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 SUPERFAMILY SSF49303 226 328 2.42E-5 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 SUPERFAMILY SSF49785 22 74 3.12E-24 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS25035 fef8c4720979a04b2e1e91f2375662d2 947 SUPERFAMILY SSF49785 114 219 3.12E-24 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 SUPERFAMILY SSF52540 243 479 2.6E-42 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 PANTHER PTHR24220:SF557 7 383 3.6E-78 T 21-04-2016 SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 PANTHER PTHR24220 7 383 3.6E-78 T 21-04-2016 SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 SUPERFAMILY SSF52540 117 236 6.25E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 Gene3D G3DSA:3.40.50.300 4 236 1.3E-33 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 SMART SM00382 284 476 0.0029 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 SMART SM00382 30 226 8.3E-7 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 Pfam PF00005 ABC transporter 21 175 3.2E-18 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 Pfam PF00005 ABC transporter 275 427 1.1E-21 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 Gene3D G3DSA:3.40.50.300 261 483 8.2E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS11250 a92d509dd129936e30b58e634b35f8a4 487 SUPERFAMILY SSF52540 3 89 6.25E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04435 1063e5f1e3267199255e810aefcaec4d 304 Pfam PF02678 Pirin 17 124 6.5E-32 T 21-04-2016 IPR003829 Pirin, N-terminal domain SPH21_RS04435 1063e5f1e3267199255e810aefcaec4d 304 SUPERFAMILY SSF51182 16 286 7.13E-70 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS04435 1063e5f1e3267199255e810aefcaec4d 304 PANTHER PTHR13903 1 290 1.4E-95 T 21-04-2016 IPR012093 Pirin SPH21_RS04435 1063e5f1e3267199255e810aefcaec4d 304 Gene3D G3DSA:2.60.120.10 16 246 1.3E-61 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS04435 1063e5f1e3267199255e810aefcaec4d 304 PANTHER PTHR13903:SF4 1 290 1.4E-95 T 21-04-2016 SPH21_RS04435 1063e5f1e3267199255e810aefcaec4d 304 PIRSF PIRSF006232 1 283 4.2E-79 T 21-04-2016 IPR012093 Pirin SPH21_RS04435 1063e5f1e3267199255e810aefcaec4d 304 Pfam PF05726 Pirin C-terminal cupin domain 177 274 2.0E-20 T 21-04-2016 IPR008778 Pirin, C-terminal domain SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Gene3D G3DSA:2.40.240.10 461 547 4.2E-29 T 21-04-2016 IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Gene3D G3DSA:2.40.240.10 345 460 3.1E-43 T 21-04-2016 IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PANTHER PTHR11451:SF29 8 245 1.8E-219 T 21-04-2016 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PANTHER PTHR11451:SF29 264 552 1.8E-219 T 21-04-2016 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Gene3D G3DSA:3.40.50.620 27 95 5.0E-41 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Gene3D G3DSA:3.40.50.620 210 259 5.0E-41 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PANTHER PTHR11451 8 245 1.8E-219 T 21-04-2016 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PANTHER PTHR11451 264 552 1.8E-219 T 21-04-2016 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PRINTS PR00987 Glutamyl-tRNA synthetase signature 59 72 3.2E-8 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PRINTS PR00987 Glutamyl-tRNA synthetase signature 208 218 3.2E-8 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PRINTS PR00987 Glutamyl-tRNA synthetase signature 44 55 3.2E-8 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 PRINTS PR00987 Glutamyl-tRNA synthetase signature 30 42 3.2E-8 T 21-04-2016 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 33 44 - T 21-04-2016 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 SUPERFAMILY SSF50715 337 547 2.46E-64 T 21-04-2016 IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain GO:0006412 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Pfam PF00749 tRNA synthetases class I (E and Q), catalytic domain 27 334 6.0E-108 T 21-04-2016 IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain GO:0005524|GO:0016876|GO:0043039 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Pfam PF03950 tRNA synthetases class I (E and Q), anti-codon binding domain 337 529 1.1E-51 T 21-04-2016 IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0006418 Reactome: REACT_71 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 SUPERFAMILY SSF52374 27 343 1.13E-96 T 21-04-2016 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Gene3D G3DSA:3.90.800.10 99 207 1.3E-44 T 21-04-2016 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Hamap MF_00126 Glutamine--tRNA ligase [glnS]. 2 549 49.781 T 21-04-2016 IPR022861 Glutamine-tRNA ligase, bacterial GO:0004819 KEGG: 00970+6.1.1.18 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 TIGRFAM TIGR00440 glnS: glutamine--tRNA ligase 27 551 9.0E-233 T 21-04-2016 IPR004514 Glutamine-tRNA synthetase GO:0000166|GO:0004819|GO:0005524|GO:0005737|GO:0006425 KEGG: 00970+6.1.1.18 SPH21_RS03805 628b8853fd49b0be6b3278e66f76cb96 557 Gene3D G3DSA:1.10.1160.10 260 336 2.1E-38 T 21-04-2016 IPR020061 Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0006418 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: REACT_71 SPH21_RS16460 ac40855885e1e94ff6bb7dcf477cf882 103 Hamap MF_01363 50S ribosomal protein L21 [rplU]. 1 103 25.028 T 21-04-2016 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16460 ac40855885e1e94ff6bb7dcf477cf882 103 ProSitePatterns PS01169 Ribosomal protein L21 signature. 72 94 - T 21-04-2016 IPR018258 Ribosomal protein L21, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16460 ac40855885e1e94ff6bb7dcf477cf882 103 Pfam PF00829 Ribosomal prokaryotic L21 protein 1 101 1.3E-39 T 21-04-2016 IPR028909 Ribosomal protein L21-like GO:0005840 SPH21_RS16460 ac40855885e1e94ff6bb7dcf477cf882 103 SUPERFAMILY SSF141091 1 102 4.97E-36 T 21-04-2016 IPR028909 Ribosomal protein L21-like GO:0005840 SPH21_RS16460 ac40855885e1e94ff6bb7dcf477cf882 103 PANTHER PTHR21349 1 101 2.4E-36 T 21-04-2016 SPH21_RS16460 ac40855885e1e94ff6bb7dcf477cf882 103 TIGRFAM TIGR00061 L21: ribosomal protein bL21 2 101 1.7E-33 T 21-04-2016 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 SUPERFAMILY SSF49464 70 149 4.05E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 Gene3D G3DSA:2.60.40.1120 71 148 6.8E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 PANTHER PTHR11532:SF57 66 396 3.2E-243 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 PANTHER PTHR11532:SF57 550 1075 3.2E-243 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 PANTHER PTHR11532:SF57 431 459 3.2E-243 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 Pfam PF13715 CarboxypepD_reg-like domain 71 151 6.4E-15 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 Pfam PF07715 TonB-dependent Receptor Plug Domain 160 261 1.9E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 SUPERFAMILY SSF56935 467 823 3.66E-80 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 SUPERFAMILY SSF56935 993 1077 3.66E-80 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 SUPERFAMILY SSF56935 341 430 3.66E-80 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 SUPERFAMILY SSF56935 900 948 3.66E-80 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 SUPERFAMILY SSF56935 147 286 3.66E-80 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 Gene3D G3DSA:2.40.170.20 345 825 6.3E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 Gene3D G3DSA:2.40.170.20 897 959 6.3E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 Gene3D G3DSA:2.40.170.20 1002 1077 6.3E-20 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 70 1077 6.1E-248 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 PANTHER PTHR11532 66 396 3.2E-243 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 PANTHER PTHR11532 550 1075 3.2E-243 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 PANTHER PTHR11532 431 459 3.2E-243 T 21-04-2016 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 238 267 4.2E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02995 42dd7813966b6b2857b8c8e9d65ebb8e 1077 Gene3D G3DSA:2.170.130.10 149 270 1.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09740 68f327fd7ca86a676c9c4512896416a9 521 PANTHER PTHR35148:SF10 1 305 1.9E-85 T 21-04-2016 SPH21_RS09740 68f327fd7ca86a676c9c4512896416a9 521 PANTHER PTHR35148:SF10 328 521 1.9E-85 T 21-04-2016 SPH21_RS09740 68f327fd7ca86a676c9c4512896416a9 521 PANTHER PTHR35148 1 305 1.9E-85 T 21-04-2016 SPH21_RS09740 68f327fd7ca86a676c9c4512896416a9 521 PANTHER PTHR35148 328 521 1.9E-85 T 21-04-2016 SPH21_RS09740 68f327fd7ca86a676c9c4512896416a9 521 Pfam PF12771 Starch-binding associating with outer membrane 5 518 3.1E-59 T 21-04-2016 SPH21_RS09740 68f327fd7ca86a676c9c4512896416a9 521 SUPERFAMILY SSF48452 20 520 1.52E-125 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10095 8f145a659e1589b9d56eff026176af04 154 PANTHER PTHR26402 6 122 1.2E-28 T 21-04-2016 SPH21_RS10095 8f145a659e1589b9d56eff026176af04 154 Gene3D G3DSA:3.40.50.2300 6 136 5.4E-33 T 21-04-2016 SPH21_RS10095 8f145a659e1589b9d56eff026176af04 154 SMART SM00448 6 117 8.7E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10095 8f145a659e1589b9d56eff026176af04 154 Pfam PF00072 Response regulator receiver domain 8 117 2.2E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10095 8f145a659e1589b9d56eff026176af04 154 SUPERFAMILY SSF52172 4 151 5.83E-34 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 SUPERFAMILY SSF55021 377 437 3.05E-11 T 21-04-2016 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 Pfam PF00696 Amino acid kinase family 2 276 4.3E-37 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 SUPERFAMILY SSF53633 1 290 8.38E-66 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 Gene3D G3DSA:3.40.1160.10 1 50 5.2E-58 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 Gene3D G3DSA:3.40.1160.10 107 290 5.2E-58 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 PANTHER PTHR21499:SF3 3 438 6.2E-118 T 21-04-2016 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 TIGRFAM TIGR00657 asp_kinases: aspartate kinase 3 438 3.0E-88 T 21-04-2016 IPR001341 Aspartate kinase domain GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 SUPERFAMILY SSF55021 296 383 2.06E-17 T 21-04-2016 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 PIRSF PIRSF000726 1 438 1.6E-92 T 21-04-2016 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 ProSitePatterns PS00324 Aspartokinase signature. 3 11 - T 21-04-2016 IPR018042 Aspartate kinase, conserved site GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS15790 49237fd49ca272d74425c9d3c09d4a60 438 PANTHER PTHR21499 3 438 6.2E-118 T 21-04-2016 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 PANTHER PTHR10949 5 285 3.8E-150 T 21-04-2016 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 Pfam PF16881 N-terminal domain of lipoyl synthase of Radical_SAM family 14 50 1.3E-6 T 21-04-2016 IPR031691 Lipoyl synthase, N-terminal KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 TIGRFAM TIGR00510 lipA: lipoyl synthase 10 288 1.0E-108 T 21-04-2016 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 SUPERFAMILY SSF102114 26 286 4.45E-60 T 21-04-2016 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 Hamap MF_00206 Lipoyl synthase [lipA]. 1 293 133.698 T 21-04-2016 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 SMART SM00729 61 267 1.9E-7 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 Gene3D G3DSA:3.20.20.70 29 287 6.9E-66 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 Pfam PF04055 Radical SAM superfamily 67 225 3.6E-15 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS25915 019eb7b59f778830b52a2f518329b2f1 293 PIRSF PIRSF005963 6 293 7.7E-128 T 21-04-2016 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 Gene3D G3DSA:1.10.10.60 208 263 1.4E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 PANTHER PTHR11019 149 314 1.6E-24 T 21-04-2016 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 SUPERFAMILY SSF46689 263 312 2.64E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 PANTHER PTHR11019:SF61 149 314 1.6E-24 T 21-04-2016 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 Gene3D G3DSA:1.10.10.60 264 309 9.2E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 279 294 2.0E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 294 310 2.0E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 264 306 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 SMART SM00342 227 310 3.0E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS01435 7bc4d70a7a4193b9d5487a1184136632 314 Pfam PF12833 Helix-turn-helix domain 234 309 1.1E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 PANTHER PTHR11958:SF61 9 404 2.1E-124 T 21-04-2016 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 PANTHER PTHR11958 9 404 2.1E-124 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 PRINTS PR00173 Glutamate-aspartate symporter signature 294 320 1.8E-8 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 PRINTS PR00173 Glutamate-aspartate symporter signature 192 211 1.8E-8 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 PRINTS PR00173 Glutamate-aspartate symporter signature 145 167 1.8E-8 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 PRINTS PR00173 Glutamate-aspartate symporter signature 12 32 1.8E-8 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 PRINTS PR00173 Glutamate-aspartate symporter signature 357 377 1.8E-8 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 Gene3D G3DSA:1.10.3860.10 9 406 1.1E-72 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 Pfam PF00375 Sodium:dicarboxylate symporter family 16 403 1.0E-92 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12600 75a38e79d967b0ff7e336fd98e574de5 406 SUPERFAMILY SSF118215 16 403 1.11E-77 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS09720 dad4d4caef127f08fbe5dc6eb2386fa6 425 Pfam PF04230 Polysaccharide pyruvyl transferase 44 347 3.0E-12 T 21-04-2016 IPR007345 Polysaccharide pyruvyl transferase SPH21_RS19015 b8eb625d709bf04c55a05b112cb188e5 321 PANTHER PTHR30160:SF1 1 307 1.5E-33 T 21-04-2016 SPH21_RS19015 b8eb625d709bf04c55a05b112cb188e5 321 PANTHER PTHR30160 1 307 1.5E-33 T 21-04-2016 SPH21_RS19015 b8eb625d709bf04c55a05b112cb188e5 321 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 76 308 3.2E-30 T 21-04-2016 IPR002201 Glycosyl transferase, family 9 GO:0008152|GO:0016757 SPH21_RS19015 b8eb625d709bf04c55a05b112cb188e5 321 Gene3D G3DSA:3.40.50.2000 166 301 1.2E-33 T 21-04-2016 SPH21_RS19015 b8eb625d709bf04c55a05b112cb188e5 321 Gene3D G3DSA:3.40.50.2000 4 153 9.7E-22 T 21-04-2016 SPH21_RS19015 b8eb625d709bf04c55a05b112cb188e5 321 SUPERFAMILY SSF53756 2 313 1.46E-65 T 21-04-2016 SPH21_RS12675 05257c79d53c56e9d742c51e1d8c49ce 317 Pfam PF00149 Calcineurin-like phosphoesterase 43 262 1.4E-11 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS12675 05257c79d53c56e9d742c51e1d8c49ce 317 SUPERFAMILY SSF56300 41 311 5.78E-43 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS12675 05257c79d53c56e9d742c51e1d8c49ce 317 Gene3D G3DSA:3.60.21.10 41 304 9.1E-39 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 SUPERFAMILY SSF56935 102 816 2.24E-110 T 21-04-2016 SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 SUPERFAMILY SSF49464 31 121 2.16E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 TIGRFAM TIGR01783 TonB-siderophor: TonB-dependent siderophore receptor 145 816 2.5E-85 T 21-04-2016 IPR010105 TonB-dependent siderophore receptor GO:0004872|GO:0005506|GO:0015891 SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 Gene3D G3DSA:2.170.130.10 115 252 4.7E-28 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 Gene3D G3DSA:2.40.170.20 256 816 5.4E-112 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 PANTHER PTHR32552:SF10 106 816 3.1E-96 T 21-04-2016 SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 ProSitePatterns PS01156 TonB-dependent receptor proteins signature 2. 799 816 - T 21-04-2016 IPR010917 TonB-dependent receptor, conserved site SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 PANTHER PTHR32552 106 816 3.1E-96 T 21-04-2016 SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 Pfam PF13715 CarboxypepD_reg-like domain 31 117 2.5E-18 T 21-04-2016 SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 Gene3D G3DSA:2.60.40.1120 31 114 1.1E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS16925 2571265ac90f846fdef4a1fa8c518d6b 816 Pfam PF07715 TonB-dependent Receptor Plug Domain 142 234 3.0E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 Gene3D G3DSA:1.10.760.10 49 192 8.5E-37 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 Gene3D G3DSA:1.10.760.10 193 345 2.3E-38 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 SUPERFAMILY SSF46626 37 190 5.03E-38 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 Pfam PF03150 Di-haem cytochrome c peroxidase 56 203 9.1E-41 T 21-04-2016 IPR004852 Di-haem cytochrome c peroxidase GO:0016491|GO:0055114 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 PIRSF PIRSF000294 11 346 1.1E-68 T 21-04-2016 IPR026259 Di-c-type haem protein, MauG/cytochrome c peroxidase GO:0016491|GO:0020037|GO:0055114 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 PANTHER PTHR30600 49 344 9.5E-62 T 21-04-2016 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 SUPERFAMILY SSF46626 180 334 3.02E-25 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS24830 db6924fb577b2a732286826901d73ee4 355 PANTHER PTHR30600:SF7 49 344 9.5E-62 T 21-04-2016 SPH21_RS10250 aaf22360f2805c77273521b63e93b56a 300 PANTHER PTHR21535 12 300 9.6E-39 T 21-04-2016 SPH21_RS10250 aaf22360f2805c77273521b63e93b56a 300 Pfam PF01544 CorA-like Mg2+ transporter protein 12 296 7.8E-62 T 21-04-2016 IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB GO:0016020|GO:0030001|GO:0046873|GO:0055085 SPH21_RS10250 aaf22360f2805c77273521b63e93b56a 300 Gene3D G3DSA:3.30.460.20 4 109 9.5E-20 T 21-04-2016 SPH21_RS10250 aaf22360f2805c77273521b63e93b56a 300 SUPERFAMILY SSF143865 5 233 5.62E-34 T 21-04-2016 SPH21_RS10250 aaf22360f2805c77273521b63e93b56a 300 SUPERFAMILY SSF144083 235 298 4.58E-22 T 21-04-2016 SPH21_RS10250 aaf22360f2805c77273521b63e93b56a 300 Gene3D G3DSA:1.20.58.340 224 300 4.2E-31 T 21-04-2016 SPH21_RS05050 861ec97ddbc950e0603ce6709e934dc7 230 Gene3D G3DSA:3.90.79.10 5 137 1.4E-40 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS05050 861ec97ddbc950e0603ce6709e934dc7 230 PANTHER PTHR22769:SF33 1 203 1.0E-36 T 21-04-2016 SPH21_RS05050 861ec97ddbc950e0603ce6709e934dc7 230 Gene3D G3DSA:1.10.10.10 142 220 2.0E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS05050 861ec97ddbc950e0603ce6709e934dc7 230 PANTHER PTHR22769 1 203 1.0E-36 T 21-04-2016 SPH21_RS05050 861ec97ddbc950e0603ce6709e934dc7 230 Pfam PF00293 NUDIX domain 12 126 5.2E-14 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS05050 861ec97ddbc950e0603ce6709e934dc7 230 SUPERFAMILY SSF46785 149 217 4.08E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS05050 861ec97ddbc950e0603ce6709e934dc7 230 SUPERFAMILY SSF55811 5 144 3.38E-31 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS21355 132709abb7a3e5646ad0a997318c8e63 784 Pfam PF12704 MacB-like periplasmic core domain 20 234 5.3E-16 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS21355 132709abb7a3e5646ad0a997318c8e63 784 Pfam PF02687 FtsX-like permease family 287 399 2.7E-14 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS21355 132709abb7a3e5646ad0a997318c8e63 784 Pfam PF02687 FtsX-like permease family 664 773 3.4E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS21355 132709abb7a3e5646ad0a997318c8e63 784 PANTHER PTHR30572:SF4 395 784 2.1E-70 T 21-04-2016 SPH21_RS21355 132709abb7a3e5646ad0a997318c8e63 784 PANTHER PTHR30572:SF4 283 353 2.1E-70 T 21-04-2016 SPH21_RS21355 132709abb7a3e5646ad0a997318c8e63 784 PANTHER PTHR30572 395 784 2.1E-70 T 21-04-2016 SPH21_RS21355 132709abb7a3e5646ad0a997318c8e63 784 PANTHER PTHR30572 283 353 2.1E-70 T 21-04-2016 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PRINTS PR01410 Cytochrome c-type biogenesis protein signature 238 264 1.3E-26 T 21-04-2016 IPR003567 Cytochrome c-type biogenesis protein GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PRINTS PR01410 Cytochrome c-type biogenesis protein signature 91 117 1.3E-26 T 21-04-2016 IPR003567 Cytochrome c-type biogenesis protein GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PRINTS PR01410 Cytochrome c-type biogenesis protein signature 272 292 1.3E-26 T 21-04-2016 IPR003567 Cytochrome c-type biogenesis protein GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PRINTS PR01410 Cytochrome c-type biogenesis protein signature 302 322 1.3E-26 T 21-04-2016 IPR003567 Cytochrome c-type biogenesis protein GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PRINTS PR01410 Cytochrome c-type biogenesis protein signature 188 210 1.3E-26 T 21-04-2016 IPR003567 Cytochrome c-type biogenesis protein GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 SUPERFAMILY SSF103473 181 540 1.83E-7 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 SUPERFAMILY SSF103473 783 813 1.83E-7 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PANTHER PTHR30009 9 449 8.8E-72 T 21-04-2016 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PANTHER PTHR30009 490 554 8.8E-72 T 21-04-2016 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 Pfam PF01578 Cytochrome C assembly protein 104 323 2.5E-22 T 21-04-2016 IPR002541 Cytochrome c assembly protein GO:0017004|GO:0020037 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PANTHER PTHR30009:SF0 9 449 8.8E-72 T 21-04-2016 IPR003567 Cytochrome c-type biogenesis protein GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 PANTHER PTHR30009:SF0 490 554 8.8E-72 T 21-04-2016 IPR003567 Cytochrome c-type biogenesis protein GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS15625 035320b03b4c525e91bf17663b63cf2a 816 Pfam PF16327 Cytochrome c-type biogenesis protein CcmF C-terminal 360 552 2.0E-11 T 21-04-2016 IPR032523 Cytochrome c-type biogenesis protein CcmF, C-terminal SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 Pfam PF04552 Sigma-54, DNA binding domain 330 488 6.7E-56 T 21-04-2016 IPR007634 RNA polymerase sigma factor 54, DNA-binding SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 PIRSF PIRSF000774 1 490 1.3E-137 T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 PRINTS PR00045 Sigma-54 factor signature 406 417 1.1E-23 T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 PRINTS PR00045 Sigma-54 factor signature 190 207 1.1E-23 T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 PRINTS PR00045 Sigma-54 factor signature 464 482 1.1E-23 T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 PRINTS PR00045 Sigma-54 factor signature 390 402 1.1E-23 T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 PANTHER PTHR32248 1 490 1.8E-142 T 21-04-2016 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 ProSitePatterns PS00718 Sigma-54 factors family signature 2. 469 476 - T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 PANTHER PTHR32248:SF4 1 490 1.8E-142 T 21-04-2016 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 TIGRFAM TIGR02395 rpoN_sigma: RNA polymerase sigma-54 factor 10 488 3.7E-128 T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 Pfam PF00309 Sigma-54 factor, Activator interacting domain (AID) 3 47 4.0E-13 T 21-04-2016 IPR000394 RNA polymerase sigma factor 54 GO:0003677|GO:0003700|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SPH21_RS01610 893ac383733a16ce7010082c8b822f12 490 Pfam PF04963 Sigma-54 factor, core binding domain 118 308 1.2E-52 T 21-04-2016 IPR007046 RNA polymerase sigma factor 54, core-binding GO:0003677|GO:0006352 SPH21_RS15270 9a53bcfef79acc4a14a1eea1191d8e8e 257 ProSitePatterns PS00211 ABC transporters family signature. 152 166 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS15270 9a53bcfef79acc4a14a1eea1191d8e8e 257 Gene3D G3DSA:3.40.50.300 11 244 1.4E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15270 9a53bcfef79acc4a14a1eea1191d8e8e 257 SMART SM00382 39 229 7.8E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS15270 9a53bcfef79acc4a14a1eea1191d8e8e 257 SUPERFAMILY SSF52540 14 244 1.73E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15270 9a53bcfef79acc4a14a1eea1191d8e8e 257 Pfam PF00005 ABC transporter 30 180 6.8E-32 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS15270 9a53bcfef79acc4a14a1eea1191d8e8e 257 PANTHER PTHR24220:SF567 16 250 3.7E-93 T 21-04-2016 SPH21_RS15270 9a53bcfef79acc4a14a1eea1191d8e8e 257 PANTHER PTHR24220 16 250 3.7E-93 T 21-04-2016 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 SUPERFAMILY SSF88659 127 200 2.96E-14 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PANTHER PTHR30603:SF0 21 285 2.5E-97 T 21-04-2016 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 Gene3D G3DSA:1.10.10.10 216 285 1.3E-26 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PIRSF PIRSF000770 10 284 1.6E-39 T 21-04-2016 IPR016263 RNA polymerase sporulation-specific sigma factor GO:0003677|GO:0006351|GO:0016987|GO:0030435 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 SUPERFAMILY SSF88659 189 285 2.62E-23 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 SUPERFAMILY SSF88946 14 123 1.06E-41 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 50 274 4.0E-35 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 Gene3D G3DSA:1.10.10.10 127 173 9.8E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PRINTS PR00046 Major sigma-70 factor signature 225 237 2.7E-24 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PRINTS PR00046 Major sigma-70 factor signature 261 272 2.7E-24 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PRINTS PR00046 Major sigma-70 factor signature 102 110 2.7E-24 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PRINTS PR00046 Major sigma-70 factor signature 78 91 2.7E-24 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PRINTS PR00046 Major sigma-70 factor signature 246 261 2.7E-24 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 Pfam PF04542 Sigma-70 region 2 56 123 8.4E-18 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 Pfam PF04545 Sigma-70, region 4 222 274 2.9E-19 T 21-04-2016 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 Pfam PF00140 Sigma-70 factor, region 1.2 17 49 1.6E-13 T 21-04-2016 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 Pfam PF04539 Sigma-70 region 3 135 202 1.4E-15 T 21-04-2016 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 Gene3D G3DSA:1.10.601.10 13 123 5.4E-49 T 21-04-2016 SPH21_RS16205 d67bd209a09b59b026cdd70390e651a6 286 PANTHER PTHR30603 21 285 2.5E-97 T 21-04-2016 SPH21_RS06370 cc7af89e45cdda59898a50097d5fa8e0 447 Pfam PF02646 RmuC family 135 432 2.2E-103 T 21-04-2016 IPR003798 DNA recombination RmuC SPH21_RS06370 cc7af89e45cdda59898a50097d5fa8e0 447 PANTHER PTHR30563 54 447 1.3E-97 T 21-04-2016 SPH21_RS09030 b95a8db87eafbeb5eab1dcb32cd37580 420 Gene3D G3DSA:3.40.50.2000 236 371 1.0E-12 T 21-04-2016 SPH21_RS09030 b95a8db87eafbeb5eab1dcb32cd37580 420 Pfam PF00534 Glycosyl transferases group 1 236 380 1.4E-19 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS09030 b95a8db87eafbeb5eab1dcb32cd37580 420 PANTHER PTHR12526:SF322 178 419 9.6E-23 T 21-04-2016 SPH21_RS09030 b95a8db87eafbeb5eab1dcb32cd37580 420 PANTHER PTHR12526 178 419 9.6E-23 T 21-04-2016 SPH21_RS09030 b95a8db87eafbeb5eab1dcb32cd37580 420 SUPERFAMILY SSF53756 21 407 4.32E-37 T 21-04-2016 SPH21_RS04085 f0ed2f41626a5debd71036acbed91c9b 114 Gene3D G3DSA:1.10.10.10 3 107 1.8E-34 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04085 f0ed2f41626a5debd71036acbed91c9b 114 PANTHER PTHR33204:SF2 1 109 4.9E-36 T 21-04-2016 SPH21_RS04085 f0ed2f41626a5debd71036acbed91c9b 114 PANTHER PTHR33204 1 109 4.9E-36 T 21-04-2016 SPH21_RS04085 f0ed2f41626a5debd71036acbed91c9b 114 Pfam PF01638 HxlR-like helix-turn-helix 20 108 6.6E-29 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS04085 f0ed2f41626a5debd71036acbed91c9b 114 SUPERFAMILY SSF46785 8 107 2.67E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 Pfam PF14716 Helix-hairpin-helix domain 3 70 1.7E-12 T 21-04-2016 IPR010996 DNA polymerase beta-like, N-terminal domain SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 PANTHER PTHR36928 323 555 9.9E-42 T 21-04-2016 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 SUPERFAMILY SSF47781 90 146 3.78E-5 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 SUPERFAMILY SSF47802 1 81 1.44E-11 T 21-04-2016 IPR010996 DNA polymerase beta-like, N-terminal domain SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 SUPERFAMILY SSF81301 157 297 9.16E-12 T 21-04-2016 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 SMART SM00483 1 297 2.0E-4 T 21-04-2016 IPR002054 DNA-directed DNA polymerase X GO:0003677|GO:0003887 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 PIRSF PIRSF005047 1 556 2.1E-155 T 21-04-2016 IPR022311 Uncharacterised conserved protein UCP005047, YshC KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 Gene3D G3DSA:1.10.150.110 1 82 9.6E-14 T 21-04-2016 IPR027421 DNA polymerase family X lyase domain SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 Gene3D G3DSA:3.30.210.10 257 297 4.3E-4 T 21-04-2016 IPR029398 DNA polymerase beta, thumb domain SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 Gene3D G3DSA:3.20.20.140 319 551 1.4E-39 T 21-04-2016 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 SUPERFAMILY SSF89550 322 551 6.28E-46 T 21-04-2016 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 Pfam PF14520 Helix-hairpin-helix domain 91 145 7.5E-6 T 21-04-2016 SPH21_RS19965 b410d208caa0da5a6057fcdc1bae76d7 560 SMART SM00481 321 401 1.1E-5 T 21-04-2016 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SPH21_RS00145 115f1afa9e9a645a44fd48f32e3879f1 435 PANTHER PTHR30026 23 435 4.5E-43 T 21-04-2016 SPH21_RS00145 115f1afa9e9a645a44fd48f32e3879f1 435 Gene3D G3DSA:1.20.1600.10 22 431 5.0E-64 T 21-04-2016 SPH21_RS00145 115f1afa9e9a645a44fd48f32e3879f1 435 Pfam PF02321 Outer membrane efflux protein 243 430 3.8E-31 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS00145 115f1afa9e9a645a44fd48f32e3879f1 435 Pfam PF02321 Outer membrane efflux protein 26 202 1.5E-25 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS00145 115f1afa9e9a645a44fd48f32e3879f1 435 SUPERFAMILY SSF56954 1 432 4.58E-74 T 21-04-2016 SPH21_RS00145 115f1afa9e9a645a44fd48f32e3879f1 435 PANTHER PTHR30026:SF7 23 435 4.5E-43 T 21-04-2016 SPH21_RS17755 a67d0c93bd35fd7c3668a0e147443170 441 TIGRFAM TIGR03779 Bac_Flav_CT_M: Bacteroides conjugative transposon TraM protein 33 440 1.1E-122 T 21-04-2016 IPR022187 Conjugative transposon, TraM SPH21_RS17755 a67d0c93bd35fd7c3668a0e147443170 441 Pfam PF12508 Protein of unknown function (DUF3714) 242 433 4.0E-70 T 21-04-2016 IPR022187 Conjugative transposon, TraM SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 PANTHER PTHR24220 8 222 3.4E-86 T 21-04-2016 SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 SMART SM00382 31 225 1.5E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 Gene3D G3DSA:3.40.50.300 5 218 7.5E-61 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 SUPERFAMILY SSF52540 7 222 1.09E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 ProSitePatterns PS00211 ABC transporters family signature. 143 157 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 35 48 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 Pfam PF00005 ABC transporter 22 170 4.5E-31 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS15535 ab73f3068048b4ede0f2601bf903f8ae 227 PANTHER PTHR24220:SF470 8 222 3.4E-86 T 21-04-2016 SPH21_RS02710 da3aad5887e268bb059bd4843239494d 249 PANTHER PTHR13767 9 221 4.6E-94 T 21-04-2016 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS02710 da3aad5887e268bb059bd4843239494d 249 SUPERFAMILY SSF55120 19 231 1.1E-69 T 21-04-2016 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS02710 da3aad5887e268bb059bd4843239494d 249 Pfam PF01509 TruB family pseudouridylate synthase (N terminal domain) 48 189 1.5E-49 T 21-04-2016 IPR002501 Pseudouridine synthase II, N-terminal GO:0006396 SPH21_RS02710 da3aad5887e268bb059bd4843239494d 249 TIGRFAM TIGR00431 TruB: tRNA pseudouridine(55) synthase 20 226 6.4E-61 T 21-04-2016 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS02710 da3aad5887e268bb059bd4843239494d 249 Hamap MF_01080 tRNA pseudouridine synthase B [truB]. 17 241 15.388 T 21-04-2016 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS02710 da3aad5887e268bb059bd4843239494d 249 PANTHER PTHR13767:SF9 9 221 4.6E-94 T 21-04-2016 SPH21_RS02710 da3aad5887e268bb059bd4843239494d 249 Pfam PF16198 tRNA pseudouridylate synthase B C-terminal domain 190 234 2.4E-10 T 21-04-2016 IPR032819 tRNA pseudouridylate synthase B, C-terminal SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 TIGRFAM TIGR00695 uxuA: mannonate dehydratase 5 381 2.3E-145 T 21-04-2016 IPR004628 Mannonate dehydratase GO:0006064|GO:0008927 KEGG: 00040+4.2.1.8|MetaCyc: PWY-7242|UniPathway: UPA00246 SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 Pfam PF03786 D-mannonate dehydratase (UxuA) 5 380 2.0E-126 T 21-04-2016 IPR004628 Mannonate dehydratase GO:0006064|GO:0008927 KEGG: 00040+4.2.1.8|MetaCyc: PWY-7242|UniPathway: UPA00246 SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 PIRSF PIRSF016049 3 383 8.0E-148 T 21-04-2016 IPR004628 Mannonate dehydratase GO:0006064|GO:0008927 KEGG: 00040+4.2.1.8|MetaCyc: PWY-7242|UniPathway: UPA00246 SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 SUPERFAMILY SSF51658 5 378 3.73E-71 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 PANTHER PTHR30387 5 384 2.3E-132 T 21-04-2016 SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 PANTHER PTHR30387:SF2 5 384 2.3E-132 T 21-04-2016 SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 Gene3D G3DSA:3.20.20.150 5 380 2.2E-135 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS02865 e3998c90e084af2be251074d5f565c5e 385 Hamap MF_00106 Mannonate dehydratase [uxuA]. 1 385 170.165 T 21-04-2016 IPR004628 Mannonate dehydratase GO:0006064|GO:0008927 KEGG: 00040+4.2.1.8|MetaCyc: PWY-7242|UniPathway: UPA00246 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 Gene3D G3DSA:3.30.470.30 280 384 5.2E-20 T 21-04-2016 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 ProSitePatterns PS00333 ATP-dependent DNA ligase signature 2. 411 435 - T 21-04-2016 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 Reactome: REACT_216 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 Pfam PF13298 DNA polymerase Ligase (LigD) 34 148 8.9E-42 T 21-04-2016 IPR014144 DNA ligase D, 3'-phosphoesterase domain SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 PANTHER PTHR10459:SF61 249 724 6.7E-53 T 21-04-2016 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 Gene3D G3DSA:3.30.1490.70 392 435 7.3E-20 T 21-04-2016 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 Gene3D G3DSA:3.30.1490.70 250 279 7.3E-20 T 21-04-2016 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 TIGRFAM TIGR02776 NHEJ_ligase_prk: DNA ligase D 270 885 6.8E-170 T 21-04-2016 IPR014143 DNA ligase D SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 Pfam PF01068 ATP dependent DNA ligase domain 267 435 1.1E-29 T 21-04-2016 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 Reactome: REACT_216 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 TIGRFAM TIGR02778 ligD_pol: DNA ligase D, polymerase domain 616 860 1.2E-73 T 21-04-2016 IPR014145 DNA ligase D, polymerase domain SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 TIGRFAM TIGR02779 NHEJ_ligase_lig: DNA ligase D, ligase domain 259 563 7.1E-87 T 21-04-2016 IPR014146 DNA ligase D, ligase domain SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 SUPERFAMILY SSF56091 253 435 2.01E-41 T 21-04-2016 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 Pfam PF04679 ATP dependent DNA ligase C terminal region 454 557 3.3E-24 T 21-04-2016 IPR012309 DNA ligase, ATP-dependent, C-terminal GO:0003910|GO:0006281|GO:0006310 Reactome: REACT_216 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 PANTHER PTHR10459 249 724 6.7E-53 T 21-04-2016 SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 SUPERFAMILY SSF50249 438 564 1.46E-24 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 TIGRFAM TIGR02777 LigD_PE_dom: DNA ligase D, 3'-phosphoesterase domain 3 166 9.7E-67 T 21-04-2016 IPR014144 DNA ligase D, 3'-phosphoesterase domain SPH21_RS12785 d31dad0a92c7eb73dc65a2961aa873d9 905 Gene3D G3DSA:2.40.50.140 438 565 2.4E-40 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS04390 3450c481e1110776b93f7da075060a4e 383 PANTHER PTHR30097 40 355 6.2E-52 T 21-04-2016 SPH21_RS04390 3450c481e1110776b93f7da075060a4e 383 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 65 298 6.3E-31 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS04390 3450c481e1110776b93f7da075060a4e 383 PANTHER PTHR30097:SF4 40 355 6.2E-52 T 21-04-2016 SPH21_RS04390 3450c481e1110776b93f7da075060a4e 383 Gene3D G3DSA:2.40.50.100 194 226 7.3E-10 T 21-04-2016 SPH21_RS04390 3450c481e1110776b93f7da075060a4e 383 Gene3D G3DSA:2.40.50.100 83 114 7.3E-10 T 21-04-2016 SPH21_RS04390 3450c481e1110776b93f7da075060a4e 383 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 70 369 8.8E-43 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS04390 3450c481e1110776b93f7da075060a4e 383 SUPERFAMILY SSF111369 79 303 1.31E-14 T 21-04-2016 SPH21_RS15485 36949141ef59b8557b88ff85c7527587 256 SUPERFAMILY SSF51306 104 211 1.57E-7 T 21-04-2016 IPR015927 Peptidase S24/S26A/S26B/S26C SPH21_RS15485 36949141ef59b8557b88ff85c7527587 256 SUPERFAMILY SSF47413 2 66 2.44E-13 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS15485 36949141ef59b8557b88ff85c7527587 256 Gene3D G3DSA:2.10.109.10 99 217 2.8E-6 T 21-04-2016 IPR028360 Peptidase S24/S26, beta-ribbon domain SPH21_RS15485 36949141ef59b8557b88ff85c7527587 256 SMART SM00530 7 62 1.6E-12 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS15485 36949141ef59b8557b88ff85c7527587 256 Pfam PF01381 Helix-turn-helix 8 62 4.3E-11 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS15485 36949141ef59b8557b88ff85c7527587 256 Gene3D G3DSA:1.10.260.40 4 98 1.3E-15 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 SUPERFAMILY SSF52172 3 128 8.68E-20 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 Pfam PF00072 Response regulator receiver domain 6 113 4.9E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 Gene3D G3DSA:2.40.50.40 136 203 4.2E-16 T 21-04-2016 SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 SMART SM00850 142 235 1.0E-22 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 Gene3D G3DSA:3.40.50.2300 3 126 2.4E-20 T 21-04-2016 SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 SMART SM00448 3 113 6.9E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 PANTHER PTHR26402 3 116 7.3E-17 T 21-04-2016 SPH21_RS04200 5553563584e1daec66394fcd5eb540fa 238 Pfam PF04397 LytTr DNA-binding domain 143 233 2.0E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS18840 3024c50a1c49ee673434a033352efdf0 62 PANTHER PTHR33990 16 59 6.2E-13 T 21-04-2016 SPH21_RS18840 3024c50a1c49ee673434a033352efdf0 62 Gene3D G3DSA:3.10.180.10 11 58 2.0E-13 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS18840 3024c50a1c49ee673434a033352efdf0 62 Pfam PF06983 3-demethylubiquinone-9 3-methyltransferase 10 46 9.3E-13 T 21-04-2016 IPR028973 3-demethylubiquinone-9 3-methyltransferase SPH21_RS18840 3024c50a1c49ee673434a033352efdf0 62 PANTHER PTHR33990:SF2 16 59 6.2E-13 T 21-04-2016 SPH21_RS18840 3024c50a1c49ee673434a033352efdf0 62 SUPERFAMILY SSF54593 13 58 3.38E-11 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS17325 8b1a89cc3833badf835ee22e8cd25087 150 Gene3D G3DSA:1.20.1170.10 12 96 2.0E-4 T 21-04-2016 SPH21_RS17325 8b1a89cc3833badf835ee22e8cd25087 150 SUPERFAMILY SSF58100 13 85 5.75E-5 T 21-04-2016 SPH21_RS03340 6ee7ef36a564d69fb499729df6c58f5f 158 Pfam PF05036 Sporulation related domain 80 148 3.0E-13 T 21-04-2016 IPR007730 Sporulation-related domain GO:0042834 SPH21_RS03340 6ee7ef36a564d69fb499729df6c58f5f 158 Gene3D G3DSA:3.30.70.1070 77 149 2.3E-8 T 21-04-2016 IPR007730 Sporulation-related domain GO:0042834 SPH21_RS03340 6ee7ef36a564d69fb499729df6c58f5f 158 SUPERFAMILY SSF110997 80 143 7.06E-10 T 21-04-2016 IPR007730 Sporulation-related domain GO:0042834 SPH21_RS24655 24ca3bda3f0c9b484f2ad7071a37c37c 320 Pfam PF12833 Helix-turn-helix domain 227 305 4.0E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24655 24ca3bda3f0c9b484f2ad7071a37c37c 320 SMART SM00342 221 304 1.5E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24655 24ca3bda3f0c9b484f2ad7071a37c37c 320 Gene3D G3DSA:1.10.10.60 220 254 5.5E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24655 24ca3bda3f0c9b484f2ad7071a37c37c 320 Gene3D G3DSA:1.10.10.60 260 306 2.5E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24655 24ca3bda3f0c9b484f2ad7071a37c37c 320 PANTHER PTHR11019:SF80 29 312 5.1E-28 T 21-04-2016 SPH21_RS24655 24ca3bda3f0c9b484f2ad7071a37c37c 320 PANTHER PTHR11019 29 312 5.1E-28 T 21-04-2016 SPH21_RS24655 24ca3bda3f0c9b484f2ad7071a37c37c 320 SUPERFAMILY SSF46689 260 310 6.72E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04355 78c41ac795ba12902b4df1e2d9ef48dd 200 ProDom PD092006 MEMBRANE YWOB TRANSMEMBRANE 16 105 4.0E-9 T 21-04-2016 IPR020218 Uncharacterised protein family, YwoB, transmembrane SPH21_RS04355 78c41ac795ba12902b4df1e2d9ef48dd 200 Pfam PF07681 DoxX 12 102 2.1E-6 T 21-04-2016 IPR032808 DoxX family SPH21_RS17910 378d972b87378cea5983ff4831207743 182 Gene3D G3DSA:3.40.50.850 1 180 5.8E-51 T 21-04-2016 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SPH21_RS17910 378d972b87378cea5983ff4831207743 182 SUPERFAMILY SSF52499 2 181 2.49E-53 T 21-04-2016 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SPH21_RS17910 378d972b87378cea5983ff4831207743 182 PANTHER PTHR11080:SF35 5 181 1.1E-57 T 21-04-2016 SPH21_RS17910 378d972b87378cea5983ff4831207743 182 Pfam PF00857 Isochorismatase family 5 178 2.6E-38 T 21-04-2016 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SPH21_RS17910 378d972b87378cea5983ff4831207743 182 PANTHER PTHR11080 5 181 1.1E-57 T 21-04-2016 SPH21_RS17955 eed84bfa4c7a3c62e5acf8b0e84f4b25 207 ProSitePatterns PS00194 Thioredoxin family active site. 96 114 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS17955 eed84bfa4c7a3c62e5acf8b0e84f4b25 207 PANTHER PTHR10681:SF68 67 188 7.4E-14 T 21-04-2016 SPH21_RS17955 eed84bfa4c7a3c62e5acf8b0e84f4b25 207 Pfam PF08534 Redoxin 72 188 1.9E-15 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS17955 eed84bfa4c7a3c62e5acf8b0e84f4b25 207 SUPERFAMILY SSF52833 51 204 4.55E-31 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS17955 eed84bfa4c7a3c62e5acf8b0e84f4b25 207 PANTHER PTHR10681 67 188 7.4E-14 T 21-04-2016 SPH21_RS17955 eed84bfa4c7a3c62e5acf8b0e84f4b25 207 Gene3D G3DSA:3.40.30.10 57 205 5.3E-37 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 Pfam PF03462 PCRF domain 10 202 1.3E-70 T 21-04-2016 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 SUPERFAMILY SSF75620 9 351 1.19E-127 T 21-04-2016 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 PANTHER PTHR11075:SF9 1 354 4.4E-160 T 21-04-2016 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 PANTHER PTHR11075 1 354 4.4E-160 T 21-04-2016 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 Hamap MF_00093 Peptide chain release factor 1 [prfA]. 1 355 38.009 T 21-04-2016 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 Gene3D G3DSA:3.30.160.20 209 285 2.8E-32 T 21-04-2016 IPR014720 Double-stranded RNA-binding domain SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 Pfam PF00472 RF-1 domain 210 319 1.7E-39 T 21-04-2016 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 SMART SM00937 63 177 2.8E-57 T 21-04-2016 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 226 242 - T 21-04-2016 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 TIGRFAM TIGR00019 prfA: peptide chain release factor 1 1 352 1.2E-145 T 21-04-2016 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 SPH21_RS07145 dbf345ce42443d1e021d1252c58a9388 357 Gene3D G3DSA:1.20.58.410 4 92 2.9E-17 T 21-04-2016 SPH21_RS10025 8d4f9ccbe7198e4a8c0b78d5be0936aa 183 PANTHER PTHR23416 24 165 1.3E-34 T 21-04-2016 SPH21_RS10025 8d4f9ccbe7198e4a8c0b78d5be0936aa 183 Gene3D G3DSA:2.160.10.10 65 166 2.5E-18 T 21-04-2016 SPH21_RS10025 8d4f9ccbe7198e4a8c0b78d5be0936aa 183 Gene3D G3DSA:1.10.3130.10 27 64 3.4E-7 T 21-04-2016 SPH21_RS10025 8d4f9ccbe7198e4a8c0b78d5be0936aa 183 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 124 156 7.6E-8 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS10025 8d4f9ccbe7198e4a8c0b78d5be0936aa 183 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 86 109 2.3E-4 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS10025 8d4f9ccbe7198e4a8c0b78d5be0936aa 183 PANTHER PTHR23416:SF55 24 165 1.3E-34 T 21-04-2016 SPH21_RS10025 8d4f9ccbe7198e4a8c0b78d5be0936aa 183 SUPERFAMILY SSF51161 31 165 9.84E-28 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 SMART SM00448 3 118 3.2E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 SMART SM00421 142 199 2.5E-10 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 SUPERFAMILY SSF52172 2 128 2.13E-25 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 ProSitePatterns PS00622 LuxR-type HTH domain signature. 159 186 - T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 PANTHER PTHR26402 3 200 3.8E-38 T 21-04-2016 SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 SUPERFAMILY SSF46894 139 205 6.12E-16 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 Gene3D G3DSA:3.40.50.2300 2 147 2.0E-27 T 21-04-2016 SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 Pfam PF00196 Bacterial regulatory proteins, luxR family 145 197 1.3E-11 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 Gene3D G3DSA:1.10.10.10 148 205 6.9E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09905 6a50d8d600f8d023f1b487b79b028698 208 Pfam PF00072 Response regulator receiver domain 6 117 1.7E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS04595 9df7b4478394ce79815f5b0c60df5eba 196 Pfam PF00027 Cyclic nucleotide-binding domain 30 116 2.4E-11 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS04595 9df7b4478394ce79815f5b0c60df5eba 196 PANTHER PTHR24567 32 189 1.1E-21 T 21-04-2016 SPH21_RS04595 9df7b4478394ce79815f5b0c60df5eba 196 PANTHER PTHR24567:SF33 32 189 1.1E-21 T 21-04-2016 SPH21_RS04595 9df7b4478394ce79815f5b0c60df5eba 196 Gene3D G3DSA:2.60.120.10 3 156 4.1E-34 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS04595 9df7b4478394ce79815f5b0c60df5eba 196 SUPERFAMILY SSF51206 16 140 9.43E-23 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS13150 c64ba6538cca81391563a4ec81afa0eb 840 PANTHER PTHR37842 57 660 1.3E-254 T 21-04-2016 SPH21_RS13150 c64ba6538cca81391563a4ec81afa0eb 840 PANTHER PTHR37842:SF2 57 660 1.3E-254 T 21-04-2016 SPH21_RS13150 c64ba6538cca81391563a4ec81afa0eb 840 Pfam PF15979 Glycosyl hydrolase family 115 194 525 1.1E-154 T 21-04-2016 IPR031924 Glycosyl hydrolase family 115 SPH21_RS13150 c64ba6538cca81391563a4ec81afa0eb 840 SUPERFAMILY SSF55545 58 177 1.41E-6 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS13150 c64ba6538cca81391563a4ec81afa0eb 840 Gene3D G3DSA:3.30.379.10 58 176 1.1E-18 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS05560 0a349f34ff5f3079d255b37731160bc3 147 TIGRFAM TIGR00621 ssb: single-stranded DNA-binding protein 2 129 2.8E-44 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS05560 0a349f34ff5f3079d255b37731160bc3 147 PIRSF PIRSF002070 1 146 2.6E-39 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS05560 0a349f34ff5f3079d255b37731160bc3 147 Gene3D G3DSA:2.40.50.140 1 147 9.7E-50 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05560 0a349f34ff5f3079d255b37731160bc3 147 PANTHER PTHR10302 1 143 3.0E-43 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS05560 0a349f34ff5f3079d255b37731160bc3 147 Hamap MF_00984 Single-stranded DNA-binding protein. 4 110 33.286 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS05560 0a349f34ff5f3079d255b37731160bc3 147 Pfam PF00436 Single-strand binding protein family 4 106 2.4E-37 T 21-04-2016 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 SPH21_RS05560 0a349f34ff5f3079d255b37731160bc3 147 SUPERFAMILY SSF50249 3 147 4.11E-50 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 Gene3D G3DSA:3.40.50.300 4 231 9.3E-76 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain 258 377 3.0E-26 T 21-04-2016 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 7 212 6.1E-57 T 21-04-2016 IPR003495 CobW/HypB/UreG, nucleotide-binding domain SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 Gene3D G3DSA:3.30.1220.10 244 377 4.9E-17 T 21-04-2016 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 SMART SM00833 258 377 1.1E-43 T 21-04-2016 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 SUPERFAMILY SSF52540 3 302 5.58E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 PANTHER PTHR13748 4 332 1.0E-178 T 21-04-2016 SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 PANTHER PTHR13748 351 392 1.0E-178 T 21-04-2016 SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 PANTHER PTHR13748:SF4 4 332 1.0E-178 T 21-04-2016 SPH21_RS12825 8e4b973948930ebd540483fb4ceef4f8 399 PANTHER PTHR13748:SF4 351 392 1.0E-178 T 21-04-2016 SPH21_RS25625 4c189b35c2326616eb605ca01296b775 221 PANTHER PTHR11911 10 121 1.5E-13 T 21-04-2016 SPH21_RS25625 4c189b35c2326616eb605ca01296b775 221 SMART SM00116 71 119 0.017 T 21-04-2016 IPR000644 CBS domain SPH21_RS25625 4c189b35c2326616eb605ca01296b775 221 SMART SM00116 10 57 0.026 T 21-04-2016 IPR000644 CBS domain SPH21_RS25625 4c189b35c2326616eb605ca01296b775 221 Gene3D G3DSA:3.10.580.10 1 120 1.5E-22 T 21-04-2016 SPH21_RS25625 4c189b35c2326616eb605ca01296b775 221 SUPERFAMILY SSF54631 1 125 1.05E-22 T 21-04-2016 SPH21_RS25625 4c189b35c2326616eb605ca01296b775 221 Pfam PF00571 CBS domain 71 119 1.5E-5 T 21-04-2016 IPR000644 CBS domain SPH21_RS25625 4c189b35c2326616eb605ca01296b775 221 Pfam PF00571 CBS domain 5 56 1.4E-7 T 21-04-2016 IPR000644 CBS domain SPH21_RS07225 dda757a4c70b8204cd385398d834b640 830 Pfam PF02585 GlcNAc-PI de-N-acetylase 49 183 2.0E-14 T 21-04-2016 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related SPH21_RS07225 dda757a4c70b8204cd385398d834b640 830 SUPERFAMILY SSF52317 626 824 8.93E-13 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS07225 dda757a4c70b8204cd385398d834b640 830 Gene3D G3DSA:3.40.50.10320 47 290 1.3E-32 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS07225 dda757a4c70b8204cd385398d834b640 830 SUPERFAMILY SSF102588 47 217 5.75E-32 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS00400 1bf6fde3a85c8707067a5bf569c22ef1 189 SUPERFAMILY SSF56925 23 186 4.19E-7 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS00400 1bf6fde3a85c8707067a5bf569c22ef1 189 Gene3D G3DSA:2.40.160.20 11 162 5.4E-5 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS00400 1bf6fde3a85c8707067a5bf569c22ef1 189 Pfam PF13568 Outer membrane protein beta-barrel domain 23 170 1.3E-20 T 21-04-2016 IPR025665 Outer membrane protein beta-barrel domain SPH21_RS21880 bc6feeb4bb6f225fc34c918ba815ce49 113 SUPERFAMILY SSF81301 5 106 7.63E-8 T 21-04-2016 SPH21_RS21880 bc6feeb4bb6f225fc34c918ba815ce49 113 Gene3D G3DSA:3.30.460.10 2 104 2.7E-7 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Gene3D G3DSA:2.40.170.20 385 846 1.4E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Gene3D G3DSA:2.40.170.20 899 924 1.4E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Gene3D G3DSA:2.40.170.20 271 294 1.4E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Gene3D G3DSA:2.40.170.20 982 1077 1.4E-43 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Pfam PF13715 CarboxypepD_reg-like domain 45 125 1.4E-10 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 44 1077 2.0E-172 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Pfam PF07715 TonB-dependent Receptor Plug Domain 134 270 3.9E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 SUPERFAMILY SSF49464 43 122 4.58E-8 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Gene3D G3DSA:2.170.130.10 127 270 4.2E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 Gene3D G3DSA:2.60.40.1120 45 126 2.0E-6 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532:SF51 629 1075 1.1E-172 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532:SF51 4 209 1.1E-172 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532:SF51 237 502 1.1E-172 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532:SF51 574 607 1.1E-172 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 SUPERFAMILY SSF56935 984 1077 4.97E-78 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 SUPERFAMILY SSF56935 122 294 4.97E-78 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 SUPERFAMILY SSF56935 505 831 4.97E-78 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 SUPERFAMILY SSF56935 891 934 4.97E-78 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 SUPERFAMILY SSF56935 376 464 4.97E-78 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 246 276 6.4E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532 629 1075 1.1E-172 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532 4 209 1.1E-172 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532 237 502 1.1E-172 T 21-04-2016 SPH21_RS09545 7f9f2adbe704e21f9178246b1f8f18eb 1077 PANTHER PTHR11532 574 607 1.1E-172 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 PANTHER PTHR30069 286 909 5.6E-22 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 PANTHER PTHR30069 1 251 5.6E-22 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 PANTHER PTHR30069:SF12 286 909 5.6E-22 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 PANTHER PTHR30069:SF12 1 251 5.6E-22 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 Gene3D G3DSA:2.40.170.20 763 882 1.0E-13 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 Gene3D G3DSA:2.40.170.20 722 723 1.0E-13 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 Gene3D G3DSA:2.40.170.20 295 689 1.0E-13 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 SUPERFAMILY SSF56935 733 754 6.87E-24 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 SUPERFAMILY SSF56935 364 687 6.87E-24 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 SUPERFAMILY SSF56935 799 907 6.87E-24 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 SUPERFAMILY SSF56935 128 248 6.87E-24 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 Pfam PF14905 Outer membrane protein beta-barrel family 440 906 3.2E-38 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 Pfam PF13715 CarboxypepD_reg-like domain 28 116 9.6E-11 T 21-04-2016 SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 SUPERFAMILY SSF49464 25 115 1.22E-10 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03215 f5a407722316cc0f0774dda6b1e6986b 924 Gene3D G3DSA:2.60.40.1120 27 105 3.8E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 Pfam PF13177 DNA polymerase III, delta subunit 8 206 1.2E-41 T 21-04-2016 SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 PANTHER PTHR11669 1 89 1.9E-50 T 21-04-2016 SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 PANTHER PTHR11669 130 247 1.9E-50 T 21-04-2016 SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 SUPERFAMILY SSF52540 123 244 2.57E-36 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 SUPERFAMILY SSF52540 3 84 2.57E-36 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 Gene3D G3DSA:3.40.50.300 122 204 1.9E-45 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 Gene3D G3DSA:3.40.50.300 3 83 1.9E-45 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 PANTHER PTHR11669:SF8 1 89 1.9E-50 T 21-04-2016 SPH21_RS03765 263753a42bd29a519e331be185a49c3d 371 PANTHER PTHR11669:SF8 130 247 1.9E-50 T 21-04-2016 SPH21_RS12100 a4049ba1df893b5aec706f62c89f186c 542 Pfam PF12741 Susd and RagB outer membrane lipoprotein 18 537 5.0E-144 T 21-04-2016 IPR024302 SusD-like SPH21_RS12100 a4049ba1df893b5aec706f62c89f186c 542 PANTHER PTHR35148 6 542 3.1E-95 T 21-04-2016 SPH21_RS12100 a4049ba1df893b5aec706f62c89f186c 542 PANTHER PTHR35148:SF6 6 542 3.1E-95 T 21-04-2016 SPH21_RS12100 a4049ba1df893b5aec706f62c89f186c 542 SUPERFAMILY SSF48452 26 537 2.02E-123 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11055 1ab39f11360d200db0b65a1a6b0e57ac 738 Hamap MF_01129 Putative K(+)-stimulated pyrophosphate-energized sodium pump [hppA]. 6 703 24.323 T 21-04-2016 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 SPH21_RS11055 1ab39f11360d200db0b65a1a6b0e57ac 738 PIRSF PIRSF001265 1 712 3.8E-269 T 21-04-2016 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 SPH21_RS11055 1ab39f11360d200db0b65a1a6b0e57ac 738 TIGRFAM TIGR01104 V_PPase: V-type H(+)-translocating pyrophosphatase 10 704 4.3E-268 T 21-04-2016 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 SPH21_RS11055 1ab39f11360d200db0b65a1a6b0e57ac 738 Pfam PF03030 Inorganic H+ pyrophosphatase 18 698 6.3E-268 T 21-04-2016 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 SPH21_RS11055 1ab39f11360d200db0b65a1a6b0e57ac 738 PANTHER PTHR31998:SF0 1 713 0.0 T 21-04-2016 SPH21_RS11055 1ab39f11360d200db0b65a1a6b0e57ac 738 PANTHER PTHR31998 1 713 0.0 T 21-04-2016 SPH21_RS15845 c7f34f153272bcb5535db05c9bfcac41 219 ProSitePatterns PS01054 Transaldolase signature 1. 24 32 - T 21-04-2016 IPR018225 Transaldolase, active site GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS15845 c7f34f153272bcb5535db05c9bfcac41 219 Pfam PF00923 Transaldolase 3 206 1.6E-56 T 21-04-2016 IPR001585 Transaldolase/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS15845 c7f34f153272bcb5535db05c9bfcac41 219 SUPERFAMILY SSF51569 1 216 8.69E-72 T 21-04-2016 SPH21_RS15845 c7f34f153272bcb5535db05c9bfcac41 219 TIGRFAM TIGR00875 fsa_talC_mipB: fructose-6-phosphate aldolase 1 215 7.3E-86 T 21-04-2016 IPR004731 Transaldolase type 3B/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS15845 c7f34f153272bcb5535db05c9bfcac41 219 PANTHER PTHR10683 1 216 2.7E-73 T 21-04-2016 IPR001585 Transaldolase/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS15845 c7f34f153272bcb5535db05c9bfcac41 219 Gene3D G3DSA:3.20.20.70 1 216 2.4E-67 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15845 c7f34f153272bcb5535db05c9bfcac41 219 Hamap MF_00494 Probable transaldolase [tal]. 1 218 44.383 T 21-04-2016 IPR022999 Transaldolase type 3B, putative GO:0004801 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS04415 487a2309046d7382d01e99b492201d2a 158 SUPERFAMILY SSF46785 49 147 5.61E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04415 487a2309046d7382d01e99b492201d2a 158 Pfam PF01638 HxlR-like helix-turn-helix 61 147 4.7E-19 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS04415 487a2309046d7382d01e99b492201d2a 158 Gene3D G3DSA:1.10.10.10 37 147 7.1E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04415 487a2309046d7382d01e99b492201d2a 158 PANTHER PTHR33204 39 146 8.5E-19 T 21-04-2016 SPH21_RS15170 b8abdb405f70d9e5d4425be3cc4a2aee 112 Gene3D G3DSA:1.10.260.40 4 95 2.2E-19 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS15170 b8abdb405f70d9e5d4425be3cc4a2aee 112 SMART SM00530 7 62 5.5E-14 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS15170 b8abdb405f70d9e5d4425be3cc4a2aee 112 Pfam PF12844 Helix-turn-helix domain 5 67 8.4E-12 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS15170 b8abdb405f70d9e5d4425be3cc4a2aee 112 PANTHER PTHR10245 2 111 1.2E-12 T 21-04-2016 SPH21_RS15170 b8abdb405f70d9e5d4425be3cc4a2aee 112 SUPERFAMILY SSF47413 2 68 5.9E-17 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 PANTHER PTHR22604:SF125 29 362 8.4E-103 T 21-04-2016 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 33 156 1.4E-30 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 SUPERFAMILY SSF51735 22 184 1.08E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 Gene3D G3DSA:3.40.50.720 30 172 5.8E-46 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 PANTHER PTHR22604 29 362 8.4E-103 T 21-04-2016 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 PRINTS PR01775 Bacterial glucose-fructose oxidoreductase signature 31 44 2.3E-17 T 21-04-2016 IPR008354 Glucose-fructose oxidoreductase, bacterial MetaCyc: PWY-5530|UniPathway: UPA00815 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 PRINTS PR01775 Bacterial glucose-fructose oxidoreductase signature 328 344 2.3E-17 T 21-04-2016 IPR008354 Glucose-fructose oxidoreductase, bacterial MetaCyc: PWY-5530|UniPathway: UPA00815 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 PRINTS PR01775 Bacterial glucose-fructose oxidoreductase signature 146 160 2.3E-17 T 21-04-2016 IPR008354 Glucose-fructose oxidoreductase, bacterial MetaCyc: PWY-5530|UniPathway: UPA00815 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 PRINTS PR01775 Bacterial glucose-fructose oxidoreductase signature 84 100 2.3E-17 T 21-04-2016 IPR008354 Glucose-fructose oxidoreductase, bacterial MetaCyc: PWY-5530|UniPathway: UPA00815 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 PRINTS PR01775 Bacterial glucose-fructose oxidoreductase signature 279 294 2.3E-17 T 21-04-2016 IPR008354 Glucose-fructose oxidoreductase, bacterial MetaCyc: PWY-5530|UniPathway: UPA00815 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 Gene3D G3DSA:3.30.360.10 173 362 2.2E-41 T 21-04-2016 SPH21_RS19095 26603a63172767ea1c2c18965839c8d6 363 SUPERFAMILY SSF55347 162 322 3.11E-26 T 21-04-2016 SPH21_RS01400 0f789971a4b061457831d48ba39cc8f3 416 Pfam PF02321 Outer membrane efflux protein 28 211 1.5E-14 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS01400 0f789971a4b061457831d48ba39cc8f3 416 SUPERFAMILY SSF56954 7 412 3.4E-38 T 21-04-2016 SPH21_RS01400 0f789971a4b061457831d48ba39cc8f3 416 Gene3D G3DSA:1.20.1600.10 26 414 1.4E-25 T 21-04-2016 SPH21_RS16595 3abe862ec4994ce819c4429f058a068d 437 SUPERFAMILY SSF52266 86 119 1.16E-20 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16595 3abe862ec4994ce819c4429f058a068d 437 SUPERFAMILY SSF52266 262 417 1.16E-20 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16595 3abe862ec4994ce819c4429f058a068d 437 Gene3D G3DSA:3.40.50.1110 254 417 1.8E-23 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16595 3abe862ec4994ce819c4429f058a068d 437 Gene3D G3DSA:3.40.50.1110 84 111 1.8E-23 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16595 3abe862ec4994ce819c4429f058a068d 437 Pfam PF00657 GDSL-like Lipase/Acylhydrolase 86 406 1.4E-15 T 21-04-2016 IPR001087 GDSL lipase/esterase GO:0016788 SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 SUPERFAMILY SSF52540 459 760 1.37E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 PANTHER PTHR22683:SF41 247 862 1.2E-180 T 21-04-2016 SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 Pfam PF09397 Ftsk gamma domain 795 855 2.5E-27 T 21-04-2016 IPR018541 FtsK gamma domain SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 Pfam PF13491 4TM region of DNA translocase FtsK/SpoIIIE 53 229 1.1E-14 T 21-04-2016 IPR025199 DNA translocase FtsK, 4TM region SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 Pfam PF01580 FtsK/SpoIIIE family 488 691 1.3E-48 T 21-04-2016 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 PANTHER PTHR22683 247 862 1.2E-180 T 21-04-2016 SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 SUPERFAMILY SSF46785 794 857 2.04E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 Gene3D G3DSA:3.40.50.300 461 755 1.5E-73 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19245 6c83ed653d220d2dd4fb31911d8fc29e 872 SMART SM00843 793 858 5.1E-35 T 21-04-2016 IPR018541 FtsK gamma domain SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 PANTHER PTHR12815 259 544 8.7E-56 T 21-04-2016 SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 PANTHER PTHR12815 67 224 8.7E-56 T 21-04-2016 SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 Gene3D G3DSA:2.40.160.50 485 748 2.4E-8 T 21-04-2016 SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 PANTHER PTHR12815:SF13 565 734 8.7E-56 T 21-04-2016 SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 Pfam PF01103 Surface antigen 369 747 7.6E-19 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 PANTHER PTHR12815:SF13 259 544 8.7E-56 T 21-04-2016 SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 PANTHER PTHR12815:SF13 67 224 8.7E-56 T 21-04-2016 SPH21_RS15880 3b936f3987b40c6e8c26e8cea04856a0 784 PANTHER PTHR12815 565 734 8.7E-56 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 150 165 1.6E-15 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 6 28 1.6E-15 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 297 313 1.6E-15 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 282 297 1.6E-15 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 331 347 1.6E-15 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 Gene3D G3DSA:3.50.50.60 4 176 5.9E-28 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 Gene3D G3DSA:3.50.50.60 270 348 5.9E-28 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 PANTHER PTHR13789 5 364 7.2E-76 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 PANTHER PTHR13789:SF251 5 364 7.2E-76 T 21-04-2016 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 Pfam PF01494 FAD binding domain 6 339 7.6E-17 T 21-04-2016 IPR002938 FAD-binding domain GO:0071949 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 SUPERFAMILY SSF51905 5 171 1.46E-42 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS20825 810152df2d92bcc9ecc374d9704dbbd6 369 SUPERFAMILY SSF51905 269 358 1.46E-42 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 PRINTS PR00133 Glycosyl hydrolase family 3 signature 284 302 1.8E-6 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 PRINTS PR00133 Glycosyl hydrolase family 3 signature 102 118 1.8E-6 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 PRINTS PR00133 Glycosyl hydrolase family 3 signature 206 222 1.8E-6 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 PRINTS PR00133 Glycosyl hydrolase family 3 signature 128 147 1.8E-6 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 Gene3D G3DSA:3.20.20.300 51 381 1.1E-90 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 SUPERFAMILY SSF51445 33 398 1.68E-87 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 47 362 5.2E-80 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 PANTHER PTHR30480:SF5 30 558 6.6E-113 T 21-04-2016 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 284 301 - T 21-04-2016 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 SPH21_RS03880 cc263bae9771ec3609a4fb0549fda167 568 PANTHER PTHR30480 30 558 6.6E-113 T 21-04-2016 SPH21_RS25615 9dd8e0686d213df3f2cfd037579cafa3 271 Pfam PF13505 Outer membrane protein beta-barrel domain 7 197 2.2E-9 T 21-04-2016 IPR027385 Outer membrane protein beta-barrel SPH21_RS25615 9dd8e0686d213df3f2cfd037579cafa3 271 SUPERFAMILY SSF56925 28 200 9.16E-7 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 SUPERFAMILY SSF82714 183 264 5.36E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 Gene3D G3DSA:1.10.3850.10 279 420 5.7E-39 T 21-04-2016 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 PRINTS PR00702 Acriflavin resistance protein family signature 331 354 7.0E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 PRINTS PR00702 Acriflavin resistance protein family signature 12 36 7.0E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 PRINTS PR00702 Acriflavin resistance protein family signature 40 58 7.0E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 PRINTS PR00702 Acriflavin resistance protein family signature 358 379 7.0E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 PRINTS PR00702 Acriflavin resistance protein family signature 386 410 7.0E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 Pfam PF00873 AcrB/AcrD/AcrF family 5 423 2.8E-108 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 Gene3D G3DSA:3.30.2090.10 182 265 9.0E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 SUPERFAMILY SSF82866 292 417 3.66E-25 T 21-04-2016 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 SUPERFAMILY SSF82693 138 182 3.92E-18 T 21-04-2016 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 SUPERFAMILY SSF82693 268 324 3.92E-18 T 21-04-2016 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 SUPERFAMILY SSF82693 44 127 5.23E-21 T 21-04-2016 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 Gene3D G3DSA:3.30.70.1430 45 142 2.0E-24 T 21-04-2016 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 PANTHER PTHR32063:SF19 2 418 3.6E-210 T 21-04-2016 SPH21_RS13955 4a9d6e5dab053c5ca3180563e25c04fc 426 PANTHER PTHR32063 2 418 3.6E-210 T 21-04-2016 SPH21_RS01275 a2f1b69a642598b027d6e547f2d14f35 393 Pfam PF03279 Bacterial lipid A biosynthesis acyltransferase 112 295 5.1E-5 T 21-04-2016 IPR004960 Bacterial lipid A biosynthesis acyltransferase GO:0016021|GO:0016740 SPH21_RS08065 2b27fe6dec22fa10b9799b8412108a66 234 SUPERFAMILY SSF53335 4 186 2.12E-10 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS08065 2b27fe6dec22fa10b9799b8412108a66 234 Pfam PF13578 Methyltransferase domain 76 121 8.6E-10 T 21-04-2016 SPH21_RS00555 0be91c812f297934d1ee9cf6b7b7de05 348 SUPERFAMILY SSF51445 47 228 9.84E-8 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS00555 0be91c812f297934d1ee9cf6b7b7de05 348 Pfam PF14488 Domain of unknown function (DUF4434) 37 204 2.1E-53 T 21-04-2016 IPR027849 Protein of unknown function DUF4434 SPH21_RS00555 0be91c812f297934d1ee9cf6b7b7de05 348 Pfam PF17134 Domain of unknown function (DUF5109) 224 337 1.1E-55 T 21-04-2016 IPR033402 Domain of unknown function DUF5109 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 ProSitePatterns PS00622 LuxR-type HTH domain signature. 161 188 - T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 SUPERFAMILY SSF52172 3 124 1.99E-25 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 Pfam PF00196 Bacterial regulatory proteins, luxR family 147 200 2.1E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 Gene3D G3DSA:3.40.50.2300 4 148 4.7E-28 T 21-04-2016 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 PANTHER PTHR26402:SF458 3 209 7.8E-41 T 21-04-2016 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 SUPERFAMILY SSF46894 132 207 1.09E-14 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 Pfam PF00072 Response regulator receiver domain 6 118 8.1E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 SMART SM00421 144 201 2.1E-8 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 SMART SM00448 3 118 1.8E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 Gene3D G3DSA:1.10.10.10 149 207 3.1E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10055 c2146e3d2cb378c69325b0b2a73639f2 209 PANTHER PTHR26402 3 209 7.8E-41 T 21-04-2016 SPH21_RS19655 5cb263ebdf0f0ef2e0e36bdb33307bc1 84 Gene3D G3DSA:1.20.58.110 1 83 1.1E-22 T 21-04-2016 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19655 5cb263ebdf0f0ef2e0e36bdb33307bc1 84 Hamap MF_00500 30S ribosomal protein S20 [rpsT]. 1 82 14.987 T 21-04-2016 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19655 5cb263ebdf0f0ef2e0e36bdb33307bc1 84 ProDom PD004231 RIBOSOMAL S20 30S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN S20P SUBUNIT CHLOROPLAST DIRECT 16 83 2.0E-14 T 21-04-2016 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19655 5cb263ebdf0f0ef2e0e36bdb33307bc1 84 TIGRFAM TIGR00029 S20: ribosomal protein bS20 1 83 4.6E-17 T 21-04-2016 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19655 5cb263ebdf0f0ef2e0e36bdb33307bc1 84 Pfam PF01649 Ribosomal protein S20 2 81 3.6E-24 T 21-04-2016 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19655 5cb263ebdf0f0ef2e0e36bdb33307bc1 84 SUPERFAMILY SSF46992 5 83 2.09E-21 T 21-04-2016 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19655 5cb263ebdf0f0ef2e0e36bdb33307bc1 84 PANTHER PTHR33398 1 84 5.8E-20 T 21-04-2016 SPH21_RS07980 17156a1cde8aa3827b5037fa80f6c62a 364 PANTHER PTHR30344 7 362 1.0E-132 T 21-04-2016 SPH21_RS07980 17156a1cde8aa3827b5037fa80f6c62a 364 Pfam PF10282 Lactonase, 7-bladed beta-propeller 17 362 3.6E-125 T 21-04-2016 IPR019405 Lactonase, 7-bladed beta propeller KEGG: 00030+3.1.1.31|UniPathway: UPA00115 SPH21_RS07980 17156a1cde8aa3827b5037fa80f6c62a 364 PANTHER PTHR30344:SF1 7 362 1.0E-132 T 21-04-2016 SPH21_RS07980 17156a1cde8aa3827b5037fa80f6c62a 364 SUPERFAMILY SSF51004 27 362 1.44E-50 T 21-04-2016 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain SPH21_RS07980 17156a1cde8aa3827b5037fa80f6c62a 364 Gene3D G3DSA:2.130.10.10 16 362 1.1E-113 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS16335 adff608f6f16d2bc5543146bb3846bd6 251 SUPERFAMILY SSF52540 2 235 6.57E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16335 adff608f6f16d2bc5543146bb3846bd6 251 ProSitePatterns PS00211 ABC transporters family signature. 149 163 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS16335 adff608f6f16d2bc5543146bb3846bd6 251 PANTHER PTHR24220:SF534 3 235 2.2E-81 T 21-04-2016 SPH21_RS16335 adff608f6f16d2bc5543146bb3846bd6 251 SMART SM00382 31 235 3.5E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS16335 adff608f6f16d2bc5543146bb3846bd6 251 Pfam PF00005 ABC transporter 22 177 1.6E-25 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS16335 adff608f6f16d2bc5543146bb3846bd6 251 PANTHER PTHR24220 3 235 2.2E-81 T 21-04-2016 SPH21_RS16335 adff608f6f16d2bc5543146bb3846bd6 251 Gene3D G3DSA:3.40.50.300 1 235 2.7E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS23645 73b3713dd253b09254048134138f7548 385 Pfam PF04041 beta-1,4-mannooligosaccharide phosphorylase 69 373 6.2E-39 T 21-04-2016 IPR007184 Mannoside phosphorylase SPH21_RS23645 73b3713dd253b09254048134138f7548 385 PANTHER PTHR34106:SF2 25 374 7.2E-104 T 21-04-2016 SPH21_RS23645 73b3713dd253b09254048134138f7548 385 SUPERFAMILY SSF75005 49 374 1.92E-66 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS23645 73b3713dd253b09254048134138f7548 385 PIRSF PIRSF016202 14 382 7.3E-100 T 21-04-2016 IPR007184 Mannoside phosphorylase SPH21_RS23645 73b3713dd253b09254048134138f7548 385 Gene3D G3DSA:2.115.10.20 25 374 6.7E-99 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS23645 73b3713dd253b09254048134138f7548 385 PANTHER PTHR34106 25 374 7.2E-104 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 SUPERFAMILY SSF81296 747 819 2.24E-11 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 710 727 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 333 354 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 304 321 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 264 284 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 411 428 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 477 495 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 504 517 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PRINTS PR00738 Glycosyl hydrolase family 20 signature 692 708 1.5E-42 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 183 306 5.8E-16 T 21-04-2016 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Gene3D G3DSA:2.60.40.290 24 142 4.2E-21 T 21-04-2016 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600 394 435 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600 678 804 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600 245 370 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600 453 658 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Pfam PF03174 Chitobiase/beta-hexosaminidase C-terminal domain 760 838 3.7E-22 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 SMART SM01081 29 191 2.0E-4 T 21-04-2016 IPR004866 Chitobiase/beta-hexosaminidases, N-terminal domain KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|UniPathway: UPA00349 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600:SF12 394 435 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600:SF12 678 804 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600:SF12 245 370 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 PANTHER PTHR22600:SF12 453 658 5.8E-135 T 21-04-2016 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Gene3D G3DSA:3.20.20.80 308 790 6.0E-129 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Pfam PF03173 Putative carbohydrate binding domain 42 120 3.4E-7 T 21-04-2016 IPR004866 Chitobiase/beta-hexosaminidases, N-terminal domain KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|UniPathway: UPA00349 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 SUPERFAMILY SSF55545 182 309 1.79E-20 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 SUPERFAMILY SSF49384 24 156 9.42E-11 T 21-04-2016 IPR008965 Carbohydrate-binding domain GO:0030246 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 SUPERFAMILY SSF51445 310 730 4.63E-115 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Gene3D G3DSA:3.30.379.10 173 306 1.4E-22 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 310 727 5.9E-93 T 21-04-2016 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS18775 a4aaa0c0f3f8841d266f2726a951c731 841 Gene3D G3DSA:2.60.40.320 791 840 1.5E-15 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 TIGRFAM TIGR00517 acyl_carrier: acyl carrier protein 1 76 6.5E-33 T 21-04-2016 IPR003231 Acyl carrier protein (ACP) GO:0006633 UniPathway: UPA00094 SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 Hamap MF_01217 Acyl carrier protein [acpP]. 3 77 21.572 T 21-04-2016 IPR003231 Acyl carrier protein (ACP) GO:0006633 UniPathway: UPA00094 SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 PANTHER PTHR20863 3 77 2.6E-27 T 21-04-2016 SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 ProDom PD000887 CARRIER ACYL PHOSPHOPANTETHEINE ACP ACID FATTY BIOSYNTHESIS LIPID SYNTHESIS CHLOROPLAST 41 76 4.0E-9 T 21-04-2016 IPR003231 Acyl carrier protein (ACP) GO:0006633 UniPathway: UPA00094 SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 ProSitePatterns PS00012 Phosphopantetheine attachment site. 32 47 - T 21-04-2016 IPR006162 Phosphopantetheine attachment site SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 Gene3D G3DSA:1.10.1200.10 3 77 1.5E-32 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 Pfam PF00550 Phosphopantetheine attachment site 7 73 7.9E-18 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS06675 34008617f3fd133a840e11873bf96343 78 SUPERFAMILY SSF47336 2 76 1.83E-23 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS00945 8f0a4ef9777947af270cf87f11a1ee91 429 Gene3D G3DSA:2.120.10.30 32 427 1.0E-43 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS00945 8f0a4ef9777947af270cf87f11a1ee91 429 PANTHER PTHR19328 268 429 9.8E-46 T 21-04-2016 SPH21_RS00945 8f0a4ef9777947af270cf87f11a1ee91 429 PANTHER PTHR19328 45 249 9.8E-46 T 21-04-2016 SPH21_RS00945 8f0a4ef9777947af270cf87f11a1ee91 429 PANTHER PTHR19328:SF33 268 429 9.8E-46 T 21-04-2016 SPH21_RS00945 8f0a4ef9777947af270cf87f11a1ee91 429 PANTHER PTHR19328:SF33 45 249 9.8E-46 T 21-04-2016 SPH21_RS00945 8f0a4ef9777947af270cf87f11a1ee91 429 SUPERFAMILY SSF50952 43 427 1.96E-23 T 21-04-2016 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SPH21_RS00945 8f0a4ef9777947af270cf87f11a1ee91 429 Pfam PF07995 Glucose / Sorbosone dehydrogenase 125 348 7.1E-8 T 21-04-2016 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3 182 8.0E-65 T 21-04-2016 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726|UniPathway: UPA00659 SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 Gene3D G3DSA:1.10.1040.10 187 282 1.7E-34 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 PIRSF PIRSF000105 1 296 2.5E-94 T 21-04-2016 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 PANTHER PTHR23309 1 283 1.5E-142 T 21-04-2016 SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 Gene3D G3DSA:3.40.50.720 1 186 1.4E-63 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 SUPERFAMILY SSF51735 1 184 5.83E-60 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 ProSitePatterns PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 182 207 - T 21-04-2016 IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726|UniPathway: UPA00659 SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 185 281 2.7E-33 T 21-04-2016 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726|UniPathway: UPA00659 SPH21_RS15480 09cc74edd020af7f33add86d8967287b 300 SUPERFAMILY SSF48179 184 287 2.64E-32 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS15115 36f41ac666025f05b6d8997d447c6a45 157 SUPERFAMILY SSF55781 11 154 1.63E-41 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS15115 36f41ac666025f05b6d8997d447c6a45 157 Gene3D G3DSA:3.30.450.40 11 155 6.7E-49 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS15115 36f41ac666025f05b6d8997d447c6a45 157 PANTHER PTHR21021 1 152 1.8E-51 T 21-04-2016 SPH21_RS15115 36f41ac666025f05b6d8997d447c6a45 157 Pfam PF13185 GAF domain 37 153 1.1E-10 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 PIRSF PIRSF018168 4 373 4.0E-80 T 21-04-2016 IPR016714 Mannan endo-1,4-beta-mannosidase GO:0006080|GO:0016985 KEGG: 00051+3.2.1.78|MetaCyc: PWY-7456 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 SUPERFAMILY SSF51445 25 359 2.45E-60 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 PANTHER PTHR40079:SF3 180 264 3.2E-12 T 21-04-2016 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 Gene3D G3DSA:3.20.20.80 25 370 5.6E-100 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 PRINTS PR00739 Glycosyl hydrolase family 26 signature 247 259 7.0E-13 T 21-04-2016 IPR000805 Glycoside hydrolase family 26 GO:0006080|GO:0016985 KEGG: 00051+3.2.1.78|MetaCyc: PWY-7456 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 PRINTS PR00739 Glycosyl hydrolase family 26 signature 113 127 7.0E-13 T 21-04-2016 IPR000805 Glycoside hydrolase family 26 GO:0006080|GO:0016985 KEGG: 00051+3.2.1.78|MetaCyc: PWY-7456 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 PRINTS PR00739 Glycosyl hydrolase family 26 signature 181 198 7.0E-13 T 21-04-2016 IPR000805 Glycoside hydrolase family 26 GO:0006080|GO:0016985 KEGG: 00051+3.2.1.78|MetaCyc: PWY-7456 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 Pfam PF02156 Glycosyl hydrolase family 26 28 293 1.7E-41 T 21-04-2016 IPR022790 Glycosyl hydrolase family 26 domain GO:0004553 SPH21_RS04585 01c5d0f1b3470c36229274ef1b9cdbab 378 PANTHER PTHR40079 180 264 3.2E-12 T 21-04-2016 IPR000805 Glycoside hydrolase family 26 GO:0006080|GO:0016985 KEGG: 00051+3.2.1.78|MetaCyc: PWY-7456 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 TIGRFAM TIGR00612 ispG_gcpE: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 24 307 1.6E-100 T 21-04-2016 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3|UniPathway: UPA00056 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 Hamap MF_00159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) [ispG]. 20 665 41.054 T 21-04-2016 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3|UniPathway: UPA00056 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 PIRSF PIRSF037336 4 670 3.5E-231 T 21-04-2016 IPR017178 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical GO:0005506|GO:0008299|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3|UniPathway: UPA00056 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 Pfam PF04551 GcpE protein 25 306 2.3E-109 T 21-04-2016 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3|UniPathway: UPA00056 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 Pfam PF04551 GcpE protein 527 661 7.9E-43 T 21-04-2016 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3|UniPathway: UPA00056 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 SUPERFAMILY SSF56014 573 661 3.27E-13 T 21-04-2016 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 SUPERFAMILY SSF51717 31 249 8.63E-6 T 21-04-2016 IPR011005 Dihydropteroate synthase-like GO:0044237 SPH21_RS10845 3b43c15aa1ddfc312798bfc98afc9588 670 PANTHER PTHR30454 12 668 3.1E-215 T 21-04-2016 SPH21_RS02955 1302db16ca2df7ef292496daef65ecaa 342 Gene3D G3DSA:2.115.10.20 18 340 8.3E-77 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02955 1302db16ca2df7ef292496daef65ecaa 342 Pfam PF04616 Glycosyl hydrolases family 43 24 324 7.6E-57 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02955 1302db16ca2df7ef292496daef65ecaa 342 PANTHER PTHR22925 24 327 1.5E-52 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02955 1302db16ca2df7ef292496daef65ecaa 342 SUPERFAMILY SSF75005 10 325 2.86E-69 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 PANTHER PTHR30173 1 182 1.1E-42 T 21-04-2016 SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 Pfam PF04542 Sigma-70 region 2 30 93 3.2E-12 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 SUPERFAMILY SSF88946 11 111 2.35E-22 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 SUPERFAMILY SSF88659 116 182 1.98E-14 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 Gene3D G3DSA:1.10.10.10 122 182 9.0E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 Gene3D G3DSA:1.10.1740.10 10 117 5.3E-25 T 21-04-2016 SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 PANTHER PTHR30173:SF20 1 182 1.1E-42 T 21-04-2016 SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 25 181 2.3E-28 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 25 182 1.3E-37 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS11150 2965688d792783ea0061b5197b9c933b 200 Pfam PF08281 Sigma-70, region 4 126 174 9.0E-15 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04490 bbac95b04eb06eaaefe4cafb875d153b 125 SUPERFAMILY SSF48600 27 114 6.41E-22 T 21-04-2016 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS04490 bbac95b04eb06eaaefe4cafb875d153b 125 SMART SM00830 35 115 1.1E-22 T 21-04-2016 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS04490 bbac95b04eb06eaaefe4cafb875d153b 125 Pfam PF01817 Chorismate mutase type II 35 113 5.9E-20 T 21-04-2016 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS04490 bbac95b04eb06eaaefe4cafb875d153b 125 Gene3D G3DSA:1.20.59.10 28 118 2.3E-20 T 21-04-2016 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626|UniPathway: UPA00120 SPH21_RS24645 b31dcab8d3af3d709d0df3b58a01b3ea 115 Gene3D G3DSA:1.10.10.10 5 113 1.2E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24645 b31dcab8d3af3d709d0df3b58a01b3ea 115 PANTHER PTHR33204 1 112 3.9E-25 T 21-04-2016 SPH21_RS24645 b31dcab8d3af3d709d0df3b58a01b3ea 115 Pfam PF01638 HxlR-like helix-turn-helix 22 110 1.2E-24 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS24645 b31dcab8d3af3d709d0df3b58a01b3ea 115 SUPERFAMILY SSF46785 17 108 9.39E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 SMART SM00342 211 294 1.2E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 Gene3D G3DSA:1.10.10.60 250 295 1.1E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 Pfam PF12833 Helix-turn-helix domain 217 295 4.0E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 SUPERFAMILY SSF46689 250 295 4.26E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 278 294 6.3E-7 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 263 278 6.3E-7 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 PANTHER PTHR11019:SF50 45 295 5.5E-31 T 21-04-2016 SPH21_RS24560 f5215d7f3cad750c267962629c71f8f3 298 PANTHER PTHR11019 45 295 5.5E-31 T 21-04-2016 SPH21_RS04450 7f0b32f9b46dca7db38be7bb4e0adb75 183 Pfam PF01872 RibD C-terminal domain 2 167 2.2E-16 T 21-04-2016 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SPH21_RS04450 7f0b32f9b46dca7db38be7bb4e0adb75 183 Gene3D G3DSA:3.40.430.10 4 181 1.9E-18 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS04450 7f0b32f9b46dca7db38be7bb4e0adb75 183 PANTHER PTHR38011:SF2 2 180 1.3E-23 T 21-04-2016 SPH21_RS04450 7f0b32f9b46dca7db38be7bb4e0adb75 183 PANTHER PTHR38011 2 180 1.3E-23 T 21-04-2016 SPH21_RS04450 7f0b32f9b46dca7db38be7bb4e0adb75 183 SUPERFAMILY SSF53597 1 182 6.03E-22 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS03985 438bbdb6b822794ee90ad9208a8da3d8 172 Gene3D G3DSA:3.40.630.30 1 172 1.2E-51 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS03985 438bbdb6b822794ee90ad9208a8da3d8 172 SUPERFAMILY SSF55729 1 160 1.74E-21 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS03985 438bbdb6b822794ee90ad9208a8da3d8 172 Pfam PF00583 Acetyltransferase (GNAT) family 86 150 3.6E-8 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 ProSitePatterns PS00488 Phenylalanine and histidine ammonia-lyases signature. 140 156 - T 21-04-2016 IPR022313 Phenylalanine/histidine ammonia-lyases, active site GO:0016841 SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 PANTHER PTHR10362 10 495 3.3E-216 T 21-04-2016 SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 Gene3D G3DSA:1.20.200.10 199 502 2.6E-114 T 21-04-2016 SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 SUPERFAMILY SSF48557 10 503 1.96E-181 T 21-04-2016 IPR008948 L-Aspartase-like GO:0003824 SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 Pfam PF00221 Aromatic amino acid lyase 12 468 1.2E-179 T 21-04-2016 IPR001106 Aromatic amino acid lyase SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 PANTHER PTHR10362:SF7 10 495 3.3E-216 T 21-04-2016 SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 TIGRFAM TIGR01225 hutH: histidine ammonia-lyase 10 501 2.4E-180 T 21-04-2016 IPR005921 Histidine ammonia-lyase GO:0004397|GO:0005737|GO:0006548 KEGG: 00340+4.3.1.3|MetaCyc: PWY-5028|MetaCyc: PWY-5030|UniPathway: UPA00379 SPH21_RS16450 9e39322c0dfea2c784ab67e3e4779a5f 522 Gene3D G3DSA:1.10.275.10 6 198 5.7E-64 T 21-04-2016 IPR024083 Fumarase/histidase, N-terminal SPH21_RS13125 63e992a5ec5d475e8032719b747eba45 520 SUPERFAMILY SSF75005 16 315 3.57E-96 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS13125 63e992a5ec5d475e8032719b747eba45 520 SUPERFAMILY SSF49899 322 516 1.7E-47 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS13125 63e992a5ec5d475e8032719b747eba45 520 PANTHER PTHR22925:SF11 16 514 7.4E-149 T 21-04-2016 SPH21_RS13125 63e992a5ec5d475e8032719b747eba45 520 Gene3D G3DSA:2.60.120.200 321 516 1.2E-52 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS13125 63e992a5ec5d475e8032719b747eba45 520 Pfam PF04616 Glycosyl hydrolases family 43 16 294 5.8E-88 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS13125 63e992a5ec5d475e8032719b747eba45 520 Gene3D G3DSA:2.115.10.20 16 304 1.0E-94 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS13125 63e992a5ec5d475e8032719b747eba45 520 PANTHER PTHR22925 16 514 7.4E-149 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 Gene3D G3DSA:3.40.50.300 582 767 6.6E-27 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 591 758 2.9E-8 T 21-04-2016 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 Pfam PF13807 G-rich domain on putative tyrosine kinase 442 518 4.6E-10 T 21-04-2016 IPR032807 Tyrosine kinase, G-rich domain SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 PANTHER PTHR32309 182 782 6.7E-121 T 21-04-2016 SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 PANTHER PTHR32309 16 126 6.7E-121 T 21-04-2016 SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 SUPERFAMILY SSF52540 584 767 1.63E-28 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 TIGRFAM TIGR01007 eps_fam: capsular exopolysaccharide family 565 770 4.3E-42 T 21-04-2016 IPR005702 Exopolysaccharide synthesis protein GO:0045226 SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 PANTHER PTHR32309:SF13 182 782 6.7E-121 T 21-04-2016 SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 PANTHER PTHR32309:SF13 16 126 6.7E-121 T 21-04-2016 SPH21_RS09675 59e0ba373de59388fd41346761085e09 788 Pfam PF02706 Chain length determinant protein 21 254 4.0E-11 T 21-04-2016 IPR003856 Lipopolysaccharide biosynthesis GO:0009103|GO:0016020 SPH21_RS13070 637912af91eb4a9b68f2e04b4ea961d6 595 Gene3D G3DSA:1.10.10.10 535 594 1.4E-6 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13070 637912af91eb4a9b68f2e04b4ea961d6 595 SUPERFAMILY SSF46894 535 592 4.76E-8 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 311 341 5.6E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 Pfam PF13715 CarboxypepD_reg-like domain 140 221 4.0E-15 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 Gene3D G3DSA:2.40.170.20 964 1128 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 Gene3D G3DSA:2.40.170.20 336 355 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 Gene3D G3DSA:2.40.170.20 421 886 1.7E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 SUPERFAMILY SSF49464 140 232 4.58E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 Pfam PF07715 TonB-dependent Receptor Plug Domain 231 335 4.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 PANTHER PTHR11532 140 466 8.1E-283 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 PANTHER PTHR11532 552 640 8.1E-283 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 PANTHER PTHR11532 669 1126 8.1E-283 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 PANTHER PTHR11532:SF57 140 466 8.1E-283 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 PANTHER PTHR11532:SF57 552 640 8.1E-283 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 PANTHER PTHR11532:SF57 669 1126 8.1E-283 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 Gene3D G3DSA:2.60.40.1120 140 222 2.9E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 140 1128 5.4E-292 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 SUPERFAMILY SSF56935 539 879 2.05E-95 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 SUPERFAMILY SSF56935 1035 1128 2.05E-95 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 SUPERFAMILY SSF56935 955 999 2.05E-95 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 SUPERFAMILY SSF56935 217 359 2.05E-95 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 SUPERFAMILY SSF56935 412 500 2.05E-95 T 21-04-2016 SPH21_RS09710 f24d8d7272922ecce0ead91338bf5dda 1128 Gene3D G3DSA:2.170.130.10 223 335 2.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19440 12bed7eaeee358322073389de078faa2 281 SUPERFAMILY SSF52518 4 275 5.89E-86 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS19440 12bed7eaeee358322073389de078faa2 281 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 11 270 4.4E-51 T 21-04-2016 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS19440 12bed7eaeee358322073389de078faa2 281 PANTHER PTHR11624 4 275 1.9E-93 T 21-04-2016 IPR033247 Transketolase family SPH21_RS19440 12bed7eaeee358322073389de078faa2 281 Gene3D G3DSA:3.40.50.970 2 276 1.9E-98 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS23425 e625bc386d1711ff28a06a244838a767 173 PANTHER PTHR23091:SF257 3 172 1.2E-38 T 21-04-2016 SPH21_RS23425 e625bc386d1711ff28a06a244838a767 173 SUPERFAMILY SSF55729 1 167 8.58E-31 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23425 e625bc386d1711ff28a06a244838a767 173 Gene3D G3DSA:3.40.630.30 6 172 2.5E-36 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23425 e625bc386d1711ff28a06a244838a767 173 Pfam PF00583 Acetyltransferase (GNAT) family 65 148 9.5E-15 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS23425 e625bc386d1711ff28a06a244838a767 173 PANTHER PTHR23091 3 172 1.2E-38 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 Gene3D G3DSA:3.30.1120.10 426 503 7.3E-15 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 Gene3D G3DSA:3.40.720.10 225 422 1.5E-99 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 Gene3D G3DSA:3.40.720.10 26 185 1.5E-99 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 SUPERFAMILY SSF53649 25 502 2.47E-117 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 ProSitePatterns PS00523 Sulfatases signature 1. 74 86 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 Pfam PF16385 Domain of unknown function 403 498 4.3E-35 T 21-04-2016 IPR032158 Domain of unknown function DUF4994 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 PANTHER PTHR10342:SF22 234 330 8.2E-136 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 PANTHER PTHR10342:SF22 1 203 8.2E-136 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 PANTHER PTHR10342:SF22 347 503 8.2E-136 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 Pfam PF00884 Sulfatase 28 400 1.4E-62 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 PANTHER PTHR10342 234 330 8.2E-136 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 PANTHER PTHR10342 1 203 8.2E-136 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 PANTHER PTHR10342 347 503 8.2E-136 T 21-04-2016 SPH21_RS20995 0a2d553be4fdfd2959313df19fe05f2f 504 ProSitePatterns PS00149 Sulfatases signature 2. 121 131 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS09065 7a4d721f942502cde730a1db5ed56471 318 PANTHER PTHR22926 1 309 4.9E-49 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS09065 7a4d721f942502cde730a1db5ed56471 318 PANTHER PTHR22926:SF3 1 309 4.9E-49 T 21-04-2016 SPH21_RS09065 7a4d721f942502cde730a1db5ed56471 318 Pfam PF00953 Glycosyl transferase family 4 65 203 4.4E-20 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 TIGRFAM TIGR00781 ccoO: cytochrome c oxidase, cbb3-type, subunit II 487 700 2.0E-76 T 21-04-2016 IPR003468 Cytochrome c oxidase, monohaem subunit/FixO SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 PANTHER PTHR10422:SF21 536 641 2.3E-296 T 21-04-2016 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 PANTHER PTHR10422:SF21 1 466 2.3E-296 T 21-04-2016 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 TIGRFAM TIGR00780 ccoN: cytochrome c oxidase, cbb3-type, subunit I 7 471 2.8E-195 T 21-04-2016 IPR004677 Cytochrome c oxidase cbb3-type, subunit I GO:0004129|GO:0045278|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 Pfam PF02433 Cytochrome C oxidase, mono-heme subunit/FixO 485 698 8.8E-99 T 21-04-2016 IPR003468 Cytochrome c oxidase, monohaem subunit/FixO SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 SUPERFAMILY SSF81442 8 486 5.23E-114 T 21-04-2016 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 Gene3D G3DSA:1.10.760.10 497 695 4.0E-28 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 11 441 1.4E-113 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 202 257 - T 21-04-2016 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 SUPERFAMILY SSF46626 496 636 1.93E-25 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 SUPERFAMILY SSF46626 669 694 1.93E-25 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 Gene3D G3DSA:1.20.210.10 8 485 5.1E-71 T 21-04-2016 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 PANTHER PTHR10422 536 641 2.3E-296 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS17550 33756829c25ea099f4ebc7738850e82d 703 PANTHER PTHR10422 1 466 2.3E-296 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS04755 24d9fe8d7464d5a7f0f97186d602114d 512 Gene3D G3DSA:1.25.40.10 200 283 9.8E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04755 24d9fe8d7464d5a7f0f97186d602114d 512 Gene3D G3DSA:1.25.40.10 332 386 9.8E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04755 24d9fe8d7464d5a7f0f97186d602114d 512 PANTHER PTHR35148 1 509 1.7E-53 T 21-04-2016 SPH21_RS04755 24d9fe8d7464d5a7f0f97186d602114d 512 Pfam PF12771 Starch-binding associating with outer membrane 1 511 2.2E-60 T 21-04-2016 SPH21_RS04755 24d9fe8d7464d5a7f0f97186d602114d 512 SUPERFAMILY SSF48452 19 511 1.39E-103 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 Pfam PF00297 Ribosomal protein L3 94 180 3.1E-13 T 21-04-2016 IPR000597 Ribosomal protein L3 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 TIGRFAM TIGR03625 L3_bact: 50S ribosomal protein uL3 3 203 4.7E-82 T 21-04-2016 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 Gene3D G3DSA:4.10.960.10 76 157 8.3E-29 T 21-04-2016 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 Gene3D G3DSA:2.40.30.10 158 194 4.0E-7 T 21-04-2016 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 Gene3D G3DSA:2.40.30.10 3 32 4.0E-7 T 21-04-2016 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 SUPERFAMILY SSF50447 1 204 9.71E-72 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS08495 4e084c97976595e28947664c1317329e 205 PANTHER PTHR11229 1 203 7.2E-99 T 21-04-2016 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 Hamap MF_01325_B 50S ribosomal protein L3 [rplC]. 1 205 35.535 T 21-04-2016 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08495 4e084c97976595e28947664c1317329e 205 ProSitePatterns PS00474 Ribosomal protein L3 signature. 100 123 - T 21-04-2016 IPR019926 Ribosomal protein L3, conserved site SPH21_RS26280 48139b72062298dbbf9ef5e82f93e189 159 SUPERFAMILY SSF52833 33 88 3.92E-11 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26280 48139b72062298dbbf9ef5e82f93e189 159 SUPERFAMILY SSF52833 115 157 3.92E-11 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26280 48139b72062298dbbf9ef5e82f93e189 159 Gene3D G3DSA:3.40.30.10 39 153 9.7E-12 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 SUPERFAMILY SSF51445 338 646 7.45E-47 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 37 212 2.6E-19 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 PANTHER PTHR10066 123 492 1.2E-51 T 21-04-2016 SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 PANTHER PTHR10066 17 90 1.2E-51 T 21-04-2016 SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 Gene3D G3DSA:2.60.40.320 223 341 2.7E-6 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 Gene3D G3DSA:2.60.120.260 27 222 5.2E-35 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 Pfam PF00703 Glycosyl hydrolases family 2 232 341 7.8E-9 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 Gene3D G3DSA:3.20.20.80 344 645 8.3E-33 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 343 492 3.9E-8 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 SUPERFAMILY SSF49785 33 82 9.07E-32 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02355 9aea3613e38a746e593f37397f9fd48d 974 SUPERFAMILY SSF49785 122 228 9.07E-32 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 Gene3D G3DSA:1.10.1740.10 2 95 2.7E-16 T 21-04-2016 SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 Pfam PF08281 Sigma-70, region 4 102 152 1.3E-10 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 SUPERFAMILY SSF88659 97 159 6.32E-11 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 PANTHER PTHR30173:SF8 2 157 3.5E-44 T 21-04-2016 SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 6 156 2.5E-25 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 Gene3D G3DSA:1.10.10.10 100 158 1.1E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 PANTHER PTHR30173 2 157 3.5E-44 T 21-04-2016 SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 Pfam PF04542 Sigma-70 region 2 9 75 8.3E-11 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS10505 ec1fcec2abd646ab4105797b32505660 163 SUPERFAMILY SSF88946 3 91 2.55E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 PANTHER PTHR10799 712 1171 1.6E-172 T 21-04-2016 SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 SUPERFAMILY SSF52540 923 1171 1.13E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 Gene3D G3DSA:3.40.50.300 710 880 4.1E-18 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 Gene3D G3DSA:3.40.50.300 1001 1148 1.6E-20 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 SMART SM00487 708 891 1.2E-26 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 Pfam PF00176 SNF2 family N-terminal domain 727 993 3.6E-55 T 21-04-2016 IPR000330 SNF2-related, N-terminal domain GO:0005524 SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 SUPERFAMILY SSF52540 691 922 1.9E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 SMART SM00490 1033 1116 2.7E-21 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS26110 2a64d99eda68d93d46f52961b8835528 1171 Pfam PF00271 Helicase conserved C-terminal domain 1005 1116 4.3E-18 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS08730 4660c528348e8e8682f770ff9445566f 305 Pfam PF13174 Tetratricopeptide repeat 228 249 0.16 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS08730 4660c528348e8e8682f770ff9445566f 305 Pfam PF13525 Outer membrane lipoprotein 38 223 5.6E-22 T 21-04-2016 SPH21_RS08730 4660c528348e8e8682f770ff9445566f 305 SUPERFAMILY SSF48452 33 109 5.58E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08730 4660c528348e8e8682f770ff9445566f 305 Gene3D G3DSA:1.25.40.10 24 111 5.2E-8 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08730 4660c528348e8e8682f770ff9445566f 305 PANTHER PTHR37423 1 215 8.1E-14 T 21-04-2016 SPH21_RS08730 4660c528348e8e8682f770ff9445566f 305 TIGRFAM TIGR03302 OM_YfiO: outer membrane assembly lipoprotein YfiO 10 218 2.0E-35 T 21-04-2016 IPR017689 Outer membrane protein assembly factor BamD SPH21_RS23255 d4e6eeb8470fa857a828a4044c2bed44 120 Pfam PF00072 Response regulator receiver domain 5 114 6.2E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23255 d4e6eeb8470fa857a828a4044c2bed44 120 Gene3D G3DSA:3.40.50.2300 3 119 1.0E-24 T 21-04-2016 SPH21_RS23255 d4e6eeb8470fa857a828a4044c2bed44 120 PANTHER PTHR26402:SF511 3 114 7.0E-19 T 21-04-2016 SPH21_RS23255 d4e6eeb8470fa857a828a4044c2bed44 120 SUPERFAMILY SSF52172 3 119 1.85E-23 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23255 d4e6eeb8470fa857a828a4044c2bed44 120 PANTHER PTHR26402 3 114 7.0E-19 T 21-04-2016 SPH21_RS23255 d4e6eeb8470fa857a828a4044c2bed44 120 SMART SM00448 3 114 2.3E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Gene3D G3DSA:2.40.50.140 629 702 4.7E-25 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Hamap MF_01595 Polyribonucleotide nucleotidyltransferase [pnp]. 4 702 29.18 T 21-04-2016 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SUPERFAMILY SSF55666 454 554 1.45E-25 T 21-04-2016 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: REACT_21257 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Pfam PF03725 3' exoribonuclease family, domain 2 150 213 1.8E-13 T 21-04-2016 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: REACT_21257 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Pfam PF03725 3' exoribonuclease family, domain 2 463 534 1.1E-4 T 21-04-2016 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: REACT_21257 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Pfam PF01138 3' exoribonuclease family, domain 1 15 146 3.1E-23 T 21-04-2016 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: REACT_21257 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Pfam PF01138 3' exoribonuclease family, domain 1 328 459 5.2E-22 T 21-04-2016 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: REACT_21257 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Gene3D G3DSA:1.10.10.400 228 319 1.9E-20 T 21-04-2016 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SUPERFAMILY SSF55666 140 230 3.23E-25 T 21-04-2016 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: REACT_21257 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 PIRSF PIRSF005499 4 717 3.5E-282 T 21-04-2016 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Gene3D G3DSA:3.30.1370.10 557 628 5.9E-22 T 21-04-2016 IPR004088 K Homology domain, type 1 GO:0003723 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 PANTHER PTHR11252 10 715 0.0 T 21-04-2016 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SMART SM00322 558 626 2.9E-9 T 21-04-2016 IPR004087 K Homology domain GO:0003676 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SUPERFAMILY SSF54211 14 146 1.57E-44 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SUPERFAMILY SSF54211 298 494 1.42E-46 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SUPERFAMILY SSF54791 558 638 1.39E-14 T 21-04-2016 IPR004088 K Homology domain, type 1 GO:0003723 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Gene3D G3DSA:3.30.230.70 4 226 7.6E-78 T 21-04-2016 IPR027408 PNPase/RNase PH domain SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Gene3D G3DSA:3.30.230.70 320 548 1.7E-77 T 21-04-2016 IPR027408 PNPase/RNase PH domain SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Pfam PF03726 Polyribonucleotide nucleotidyltransferase, RNA binding domain 244 324 1.0E-9 T 21-04-2016 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Pfam PF00575 S1 RNA binding domain 627 699 3.3E-20 T 21-04-2016 IPR003029 S1 domain GO:0003676 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 Pfam PF00013 KH domain 563 622 5.2E-10 T 21-04-2016 IPR004088 K Homology domain, type 1 GO:0003723 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SUPERFAMILY SSF50249 617 703 2.11E-22 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 TIGRFAM TIGR03591 polynuc_phos: polyribonucleotide nucleotidyltransferase 14 700 1.2E-287 T 21-04-2016 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SUPERFAMILY SSF46915 232 330 1.31E-18 T 21-04-2016 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SPH21_RS15365 38e8d3dba872f22409e65b2f69831429 717 SMART SM00316 629 699 4.8E-25 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 Pfam PF01028 Eukaryotic DNA topoisomerase I, catalytic core 91 291 1.3E-32 T 21-04-2016 IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type GO:0003677|GO:0003918|GO:0006265 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 Gene3D G3DSA:1.20.120.380 238 330 9.7E-25 T 21-04-2016 IPR027362 DNA topoisomerase I catalytic fragment, domain 2 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 PRINTS PR00416 Eukaryotic DNA topoisomerase I signature 151 165 2.5E-8 T 21-04-2016 IPR001631 DNA topoisomerase I GO:0003677|GO:0003917|GO:0006265 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 PRINTS PR00416 Eukaryotic DNA topoisomerase I signature 128 147 2.5E-8 T 21-04-2016 IPR001631 DNA topoisomerase I GO:0003677|GO:0003917|GO:0006265 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 PRINTS PR00416 Eukaryotic DNA topoisomerase I signature 237 251 2.5E-8 T 21-04-2016 IPR001631 DNA topoisomerase I GO:0003677|GO:0003917|GO:0006265 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 PRINTS PR00416 Eukaryotic DNA topoisomerase I signature 172 188 2.5E-8 T 21-04-2016 IPR001631 DNA topoisomerase I GO:0003677|GO:0003917|GO:0006265 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 SUPERFAMILY SSF56349 84 322 1.38E-62 T 21-04-2016 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 Gene3D G3DSA:3.90.15.10 94 223 4.0E-36 T 21-04-2016 IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type GO:0003677|GO:0003917|GO:0006265 SPH21_RS18345 95ef5677b5f32361b4b9fcf45af98efe 352 SUPERFAMILY SSF55869 22 88 3.01E-21 T 21-04-2016 SPH21_RS21600 fd0dbd92c11c53e87d819d297a12be51 135 SUPERFAMILY SSF143744 2 131 2.35E-34 T 21-04-2016 SPH21_RS21600 fd0dbd92c11c53e87d819d297a12be51 135 Pfam PF03928 Haem-degrading 4 128 2.1E-29 T 21-04-2016 IPR005624 Haem-degrading SPH21_RS21600 fd0dbd92c11c53e87d819d297a12be51 135 PANTHER PTHR34309 1 129 7.4E-29 T 21-04-2016 SPH21_RS21600 fd0dbd92c11c53e87d819d297a12be51 135 PANTHER PTHR34309:SF1 1 129 7.4E-29 T 21-04-2016 SPH21_RS19315 f8b96607d4383a22d447ec1a3412874e 339 PANTHER PTHR10188 38 333 4.3E-170 T 21-04-2016 IPR000246 Peptidase T2, asparaginase 2 GO:0016787 SPH21_RS19315 f8b96607d4383a22d447ec1a3412874e 339 SUPERFAMILY SSF56235 37 331 4.42E-89 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS19315 f8b96607d4383a22d447ec1a3412874e 339 Pfam PF01112 Asparaginase 50 329 6.0E-83 T 21-04-2016 IPR000246 Peptidase T2, asparaginase 2 GO:0016787 SPH21_RS19315 f8b96607d4383a22d447ec1a3412874e 339 PANTHER PTHR10188:SF23 38 333 4.3E-170 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 SUPERFAMILY SSF56935 411 499 1.33E-68 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 SUPERFAMILY SSF56935 921 964 1.33E-68 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 SUPERFAMILY SSF56935 1007 1081 1.33E-68 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 SUPERFAMILY SSF56935 217 358 1.33E-68 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 SUPERFAMILY SSF56935 536 846 1.33E-68 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Gene3D G3DSA:2.60.40.1120 141 224 2.0E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 140 1085 7.9E-223 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 SUPERFAMILY SSF49464 139 219 6.8E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 311 340 1.2E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Pfam PF00593 TonB dependent receptor 689 1083 1.2E-16 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Pfam PF13715 CarboxypepD_reg-like domain 141 221 3.9E-19 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 SMART SM00965 68 119 1.6E-8 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 PANTHER PTHR11532:SF57 614 1085 3.4E-215 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 PANTHER PTHR11532:SF57 140 500 3.4E-215 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Pfam PF07715 TonB-dependent Receptor Plug Domain 229 334 6.7E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Pfam PF07660 Secretin and TonB N terminus short domain 68 116 1.1E-8 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Gene3D G3DSA:2.40.170.20 543 846 9.5E-18 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Gene3D G3DSA:2.40.170.20 921 962 9.5E-18 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Gene3D G3DSA:2.40.170.20 420 507 9.5E-18 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 PANTHER PTHR11532 614 1085 3.4E-215 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 PANTHER PTHR11532 140 500 3.4E-215 T 21-04-2016 SPH21_RS09250 205e30056716d230a42a088bea54392b 1088 Gene3D G3DSA:2.170.130.10 225 337 5.2E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS16575 32e5c1009392044c301b1f9d9d609abc 91 SUPERFAMILY SSF52833 1 87 7.6E-22 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS16575 32e5c1009392044c301b1f9d9d609abc 91 PANTHER PTHR36417:SF2 2 91 6.5E-31 T 21-04-2016 SPH21_RS16575 32e5c1009392044c301b1f9d9d609abc 91 TIGRFAM TIGR02174 CXXU_selWTH: selT/selW/selH selenoprotein domain 6 78 9.8E-17 T 21-04-2016 IPR011893 Selenoprotein, Rdx type SPH21_RS16575 32e5c1009392044c301b1f9d9d609abc 91 Pfam PF10262 Rdx family 4 78 9.4E-26 T 21-04-2016 IPR011893 Selenoprotein, Rdx type SPH21_RS16575 32e5c1009392044c301b1f9d9d609abc 91 PANTHER PTHR36417 2 91 6.5E-31 T 21-04-2016 SPH21_RS16575 32e5c1009392044c301b1f9d9d609abc 91 Gene3D G3DSA:3.40.30.10 2 91 2.2E-36 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS20295 1e0ac5a8fb60a1bc0c6ba289a903d30f 106 Pfam PF13376 Bacteriocin-protection, YdeI or OmpD-Associated 39 96 3.3E-17 T 21-04-2016 SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 Gene3D G3DSA:1.10.150.240 16 72 4.4E-8 T 21-04-2016 IPR023198 Phosphoglycolate phosphatase, domain 2 SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 SUPERFAMILY SSF56784 1 208 3.62E-52 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 42 186 2.1E-13 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 Gene3D G3DSA:3.40.50.1000 73 209 2.8E-40 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 130 146 1.7E-6 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 3 14 1.7E-6 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 99 112 1.7E-6 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 PANTHER PTHR18901 4 211 9.3E-59 T 21-04-2016 SPH21_RS25680 583573f548657bc7ff4d3a1d6822c626 218 Pfam PF13419 Haloacid dehalogenase-like hydrolase 6 186 5.5E-35 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS03705 98d514f57777b7c1c50d484d762d7449 121 TIGRFAM TIGR00810 secG: preprotein translocase, SecG subunit 2 71 8.7E-19 T 21-04-2016 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SPH21_RS03705 98d514f57777b7c1c50d484d762d7449 121 PRINTS PR01651 Protein-export SecG membrane protein signature 3 23 5.6E-5 T 21-04-2016 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SPH21_RS03705 98d514f57777b7c1c50d484d762d7449 121 PRINTS PR01651 Protein-export SecG membrane protein signature 23 37 5.6E-5 T 21-04-2016 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SPH21_RS03705 98d514f57777b7c1c50d484d762d7449 121 Pfam PF03840 Preprotein translocase SecG subunit 4 70 1.0E-17 T 21-04-2016 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 SUPERFAMILY SSF53383 96 470 5.91E-85 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 Gene3D G3DSA:1.10.10.10 2 72 3.9E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 Gene3D G3DSA:3.40.640.10 145 351 1.1E-60 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 SMART SM00345 10 69 4.7E-17 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 Pfam PF00392 Bacterial regulatory proteins, gntR family 9 69 1.0E-13 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 PANTHER PTHR11751 92 469 3.0E-126 T 21-04-2016 SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 SUPERFAMILY SSF46785 4 73 4.99E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 PANTHER PTHR11751:SF314 92 469 3.0E-126 T 21-04-2016 SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 Pfam PF00155 Aminotransferase class I and II 136 449 3.1E-30 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS07350 f56e2e0b4fbc0ccc30d400a1408a9a22 472 Gene3D G3DSA:3.90.1150.10 352 465 1.6E-5 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS20560 b3e69b6a11cba14357d9924688364781 237 Pfam PF06439 Domain of Unknown Function (DUF1080) 34 235 4.8E-50 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS13765 b8e2a7693d82a8edcbe127e18a55144b 517 Pfam PF12771 Starch-binding associating with outer membrane 1 513 4.2E-54 T 21-04-2016 SPH21_RS13765 b8e2a7693d82a8edcbe127e18a55144b 517 SUPERFAMILY SSF48452 20 516 3.29E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13765 b8e2a7693d82a8edcbe127e18a55144b 517 PANTHER PTHR35148 316 517 1.1E-65 T 21-04-2016 SPH21_RS13765 b8e2a7693d82a8edcbe127e18a55144b 517 PANTHER PTHR35148 1 297 1.1E-65 T 21-04-2016 SPH21_RS16760 2c43eb16846130d93b7b7d485b6245c3 271 PANTHER PTHR21057:SF2 17 271 9.8E-142 T 21-04-2016 IPR006269 3-deoxy-8-phosphooctulonate synthase GO:0005737|GO:0008152|GO:0008676 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674|UniPathway: UPA00030|UniPathway: UPA00357 SPH21_RS16760 2c43eb16846130d93b7b7d485b6245c3 271 TIGRFAM TIGR01362 KDO8P_synth: 3-deoxy-8-phosphooctulonate synthase 16 270 2.4E-117 T 21-04-2016 IPR006269 3-deoxy-8-phosphooctulonate synthase GO:0005737|GO:0008152|GO:0008676 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674|UniPathway: UPA00030|UniPathway: UPA00357 SPH21_RS16760 2c43eb16846130d93b7b7d485b6245c3 271 Gene3D G3DSA:3.20.20.70 15 271 1.1E-106 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS16760 2c43eb16846130d93b7b7d485b6245c3 271 SUPERFAMILY SSF51569 4 270 4.03E-100 T 21-04-2016 SPH21_RS16760 2c43eb16846130d93b7b7d485b6245c3 271 PANTHER PTHR21057 17 271 9.8E-142 T 21-04-2016 SPH21_RS16760 2c43eb16846130d93b7b7d485b6245c3 271 Pfam PF00793 DAHP synthetase I family 9 268 6.6E-63 T 21-04-2016 IPR006218 DAHP synthetase I/KDSA GO:0009058 KEGG: 00540+2.5.1.55|MetaCyc: PWY-1269|MetaCyc: PWY-7674|UniPathway: UPA00030|UniPathway: UPA00357 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 SUPERFAMILY SSF52374 17 175 1.1E-31 T 21-04-2016 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 Gene3D G3DSA:3.40.50.620 13 181 2.2E-53 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 Pfam PF06574 FAD synthetase 14 166 2.7E-46 T 21-04-2016 IPR015864 FAD synthetase GO:0003919|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00276|UniPathway: UPA00277 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 PIRSF PIRSF004491 1 323 6.3E-99 T 21-04-2016 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00276|UniPathway: UPA00277 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 PANTHER PTHR22749 1 322 2.5E-104 T 21-04-2016 IPR023468 Riboflavin kinase KEGG: 00740+2.7.1.26|MetaCyc: PWY-5523|MetaCyc: PWY-6168|UniPathway: UPA00276 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 Pfam PF01687 Riboflavin kinase 184 322 1.2E-32 T 21-04-2016 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 TIGRFAM TIGR00083 ribF: riboflavin biosynthesis protein RibF 18 322 1.2E-72 T 21-04-2016 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00276|UniPathway: UPA00277 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 PANTHER PTHR22749:SF0 1 322 2.5E-104 T 21-04-2016 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 Gene3D G3DSA:2.40.30.30 182 323 2.5E-37 T 21-04-2016 IPR023465 Riboflavin kinase domain GO:0008531|GO:0009231 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 SMART SM00904 183 323 1.9E-51 T 21-04-2016 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 SPH21_RS02715 61010ba47fff226fc1035347c58dbca2 323 SUPERFAMILY SSF82114 175 323 3.27E-37 T 21-04-2016 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 Hamap MF_01966 NAD(P)H-hydrate epimerase [nnrE]. 6 212 20.69 T 21-04-2016 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 Gene3D G3DSA:3.40.50.10260 2 235 1.1E-53 T 21-04-2016 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 PANTHER PTHR12592:SF0 4 499 2.0E-107 T 21-04-2016 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 Gene3D G3DSA:3.40.1190.20 236 494 2.7E-75 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 Pfam PF01256 Carbohydrate kinase 250 489 7.0E-57 T 21-04-2016 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 ProSitePatterns PS01050 YjeF C-terminal domain signature 2. 433 443 - T 21-04-2016 IPR017953 Carbohydrate kinase, predicted, conserved site SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 Hamap MF_01965 ADP-dependent (S)-NAD(P)H-hydrate dehydratase [nnrD]. 227 497 21.08 T 21-04-2016 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 PANTHER PTHR12592 4 499 2.0E-107 T 21-04-2016 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 TIGRFAM TIGR00196 yjeF_cterm: YjeF family C-terminal domain 227 493 4.5E-65 T 21-04-2016 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 SUPERFAMILY SSF53613 226 493 3.93E-60 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 Pfam PF03853 YjeF-related protein N-terminus 27 189 7.1E-37 T 21-04-2016 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 SUPERFAMILY SSF64153 4 249 5.89E-49 T 21-04-2016 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 TIGRFAM TIGR00197 yjeF_nterm: YjeF family N-terminal domain 23 212 5.7E-36 T 21-04-2016 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SPH21_RS25920 60eccb4c0360e6731a2f4faba8488618 499 PIRSF PIRSF017184 2 498 2.7E-117 T 21-04-2016 IPR030677 Bifunctional NAD(P)H-hydrate repair enzyme Nnr GO:0052855 MetaCyc: PWY-6938 SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 168 4.6E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 107 118 4.6E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 37 54 4.6E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 229 4.6E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 Gene3D G3DSA:3.40.50.720 32 274 8.4E-48 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 PANTHER PTHR24320 16 325 1.2E-91 T 21-04-2016 SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 Pfam PF00106 short chain dehydrogenase 36 232 3.7E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24600 fdd29e9f54491bcaf91cffbfc7643703 331 SUPERFAMILY SSF51735 33 290 8.18E-48 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01360 3739872eab810e4f85378e8520421a0a 70 Pfam PF00403 Heavy-metal-associated domain 8 66 8.3E-5 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01360 3739872eab810e4f85378e8520421a0a 70 SUPERFAMILY SSF55008 4 68 7.85E-10 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01360 3739872eab810e4f85378e8520421a0a 70 Gene3D G3DSA:3.30.70.100 5 68 2.3E-12 T 21-04-2016 SPH21_RS16240 0f30d9d82d8f9052b42a569169c0ce29 415 PANTHER PTHR30480 35 412 1.4E-77 T 21-04-2016 SPH21_RS16240 0f30d9d82d8f9052b42a569169c0ce29 415 Pfam PF07075 Protein of unknown function (DUF1343) 64 411 4.7E-113 T 21-04-2016 IPR008302 Uncharacterised conserved protein UCP016719 SPH21_RS16240 0f30d9d82d8f9052b42a569169c0ce29 415 PANTHER PTHR30480:SF3 35 412 1.4E-77 T 21-04-2016 SPH21_RS16240 0f30d9d82d8f9052b42a569169c0ce29 415 PIRSF PIRSF016719 12 412 1.1E-94 T 21-04-2016 IPR008302 Uncharacterised conserved protein UCP016719 SPH21_RS02240 4ee29912762cd1e2ef5862c979a96182 348 PANTHER PTHR12110:SF14 243 289 1.0E-23 T 21-04-2016 SPH21_RS02240 4ee29912762cd1e2ef5862c979a96182 348 PANTHER PTHR12110:SF14 11 220 1.0E-23 T 21-04-2016 SPH21_RS02240 4ee29912762cd1e2ef5862c979a96182 348 SUPERFAMILY SSF51658 12 278 3.73E-20 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS02240 4ee29912762cd1e2ef5862c979a96182 348 PANTHER PTHR12110 243 289 1.0E-23 T 21-04-2016 SPH21_RS02240 4ee29912762cd1e2ef5862c979a96182 348 PANTHER PTHR12110 11 220 1.0E-23 T 21-04-2016 SPH21_RS02240 4ee29912762cd1e2ef5862c979a96182 348 Pfam PF01261 Xylose isomerase-like TIM barrel 47 268 2.5E-8 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS02240 4ee29912762cd1e2ef5862c979a96182 348 Gene3D G3DSA:3.20.20.150 44 262 1.3E-13 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 SUPERFAMILY SSF48208 270 747 6.63E-20 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 Gene3D G3DSA:1.20.1050.60 362 450 3.3E-15 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 Gene3D G3DSA:3.30.2080.10 625 768 3.1E-40 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 Gene3D G3DSA:2.70.98.10 17 329 4.3E-85 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 PANTHER PTHR12143 1 385 1.2E-107 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 PANTHER PTHR12143 402 449 1.2E-107 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 PANTHER PTHR12143 466 768 1.2E-107 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 Pfam PF07971 Glycosyl hydrolase family 92 247 765 4.0E-125 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 15 768 2.1E-121 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 PANTHER PTHR12143:SF22 1 385 1.2E-107 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 PANTHER PTHR12143:SF22 402 449 1.2E-107 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 PANTHER PTHR12143:SF22 466 768 1.2E-107 T 21-04-2016 SPH21_RS21035 f0091a2e9195af09db453e56c6c52d93 768 Gene3D G3DSA:1.20.1610.10 476 624 4.9E-48 T 21-04-2016 SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 Pfam PF08281 Sigma-70, region 4 124 175 1.0E-7 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 SUPERFAMILY SSF88659 111 181 6.54E-10 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 PANTHER PTHR30173 2 185 1.1E-26 T 21-04-2016 SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 SUPERFAMILY SSF88946 9 109 3.49E-18 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 Gene3D G3DSA:1.10.10.10 121 179 7.2E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 179 3.6E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 Pfam PF04542 Sigma-70 region 2 27 94 8.4E-7 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04770 58f4d59cf1f845dfb34f6640bb32ac28 199 Gene3D G3DSA:1.10.1740.10 9 109 1.4E-19 T 21-04-2016 SPH21_RS14575 7432a35ff43c05e64ec5136a6d95bccc 440 Gene3D G3DSA:3.65.10.10 228 434 1.7E-43 T 21-04-2016 IPR001986 Enolpyruvate transferase domain GO:0016765 SPH21_RS14575 7432a35ff43c05e64ec5136a6d95bccc 440 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 8 422 1.3E-59 T 21-04-2016 IPR001986 Enolpyruvate transferase domain GO:0016765 SPH21_RS14575 7432a35ff43c05e64ec5136a6d95bccc 440 TIGRFAM TIGR01072 murA: UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 433 3.9E-132 T 21-04-2016 IPR005750 UDP-N-acetylglucosamine 1-carboxyvinyltransferase GO:0008760|GO:0019277 KEGG: 00520+2.5.1.7|KEGG: 00550+2.5.1.7|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS14575 7432a35ff43c05e64ec5136a6d95bccc 440 Hamap MF_00111 UDP-N-acetylglucosamine 1-carboxyvinyltransferase [murA]. 1 434 33.976 T 21-04-2016 IPR005750 UDP-N-acetylglucosamine 1-carboxyvinyltransferase GO:0008760|GO:0019277 KEGG: 00520+2.5.1.7|KEGG: 00550+2.5.1.7|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS14575 7432a35ff43c05e64ec5136a6d95bccc 440 PANTHER PTHR21090 1 436 5.3E-132 T 21-04-2016 SPH21_RS14575 7432a35ff43c05e64ec5136a6d95bccc 440 SUPERFAMILY SSF55205 1 435 1.21E-102 T 21-04-2016 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 SPH21_RS14575 7432a35ff43c05e64ec5136a6d95bccc 440 Gene3D G3DSA:3.65.10.10 21 227 4.1E-53 T 21-04-2016 IPR001986 Enolpyruvate transferase domain GO:0016765 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 SUPERFAMILY SSF49464 25 104 1.31E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 25 981 5.7E-215 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Gene3D G3DSA:2.170.130.10 110 220 2.6E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Gene3D G3DSA:2.40.170.20 806 831 2.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Gene3D G3DSA:2.40.170.20 221 251 2.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Gene3D G3DSA:2.40.170.20 871 981 2.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Gene3D G3DSA:2.40.170.20 296 760 2.5E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 SUPERFAMILY SSF56935 102 245 1.03E-83 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 SUPERFAMILY SSF56935 287 375 1.03E-83 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 SUPERFAMILY SSF56935 797 841 1.03E-83 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 SUPERFAMILY SSF56935 883 981 1.03E-83 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 SUPERFAMILY SSF56935 406 736 1.03E-83 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Gene3D G3DSA:2.60.40.1120 26 109 7.8E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 196 226 2.7E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Pfam PF13715 CarboxypepD_reg-like domain 27 106 7.7E-12 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 PANTHER PTHR11532 1 403 1.4E-203 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 PANTHER PTHR11532 477 979 1.4E-203 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 PANTHER PTHR11532:SF57 1 403 1.4E-203 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 PANTHER PTHR11532:SF57 477 979 1.4E-203 T 21-04-2016 SPH21_RS03155 e66dc15c9e82a3d12e6cf5be3ee8c465 981 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 220 2.7E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS10285 eb4b67ceace3f1f2bdde0d7b3199cf9e 905 Gene3D G3DSA:2.60.40.920 169 226 2.2E-4 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS04560 9502c525226db521fdabfe1738a9bc21 563 Pfam PF07980 SusD family 304 553 2.5E-25 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04560 9502c525226db521fdabfe1738a9bc21 563 Pfam PF14322 Starch-binding associating with outer membrane 20 218 8.7E-32 T 21-04-2016 SPH21_RS04560 9502c525226db521fdabfe1738a9bc21 563 SUPERFAMILY SSF48452 15 553 3.92E-92 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04560 9502c525226db521fdabfe1738a9bc21 563 Gene3D G3DSA:1.25.40.10 197 351 1.1E-24 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04560 9502c525226db521fdabfe1738a9bc21 563 Gene3D G3DSA:1.25.40.10 386 479 1.1E-24 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 Pfam PF13085 2Fe-2S iron-sulfur cluster binding domain 4 120 4.6E-22 T 21-04-2016 IPR025192 Succinate dehydogenase/fumarate reductase N-terminal GO:0009055|GO:0051536 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279 SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 Gene3D G3DSA:3.10.20.30 1 111 1.2E-26 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 PANTHER PTHR11921:SF13 3 244 2.5E-118 T 21-04-2016 SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 SUPERFAMILY SSF46548 119 247 2.09E-21 T 21-04-2016 IPR009051 Alpha-helical ferredoxin GO:0051536 SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 Gene3D G3DSA:1.10.1060.10 112 246 5.5E-19 T 21-04-2016 SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 PANTHER PTHR11921 3 244 2.5E-118 T 21-04-2016 SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 Pfam PF13183 4Fe-4S dicluster domain 157 228 2.1E-10 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 58 66 - T 21-04-2016 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SPH21_RS06905 558aa9d2f37f112143ffeccb7c5c079f 253 SUPERFAMILY SSF54292 2 116 1.09E-21 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS23390 c18865ddeb2743c645a3af31389d517e 360 SUPERFAMILY SSF55874 244 356 1.05E-8 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23390 c18865ddeb2743c645a3af31389d517e 360 PANTHER PTHR34220 7 360 6.6E-60 T 21-04-2016 SPH21_RS23390 c18865ddeb2743c645a3af31389d517e 360 Pfam PF14501 GHKL domain 269 358 1.9E-7 T 21-04-2016 IPR032834 Sensor histidine kinase NatK, C-terminal domain SPH21_RS23390 c18865ddeb2743c645a3af31389d517e 360 PANTHER PTHR34220:SF1 7 360 6.6E-60 T 21-04-2016 SPH21_RS23390 c18865ddeb2743c645a3af31389d517e 360 Gene3D G3DSA:3.30.565.10 218 356 9.7E-5 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS23390 c18865ddeb2743c645a3af31389d517e 360 Pfam PF06580 Histidine kinase 169 245 3.3E-23 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS20270 9da22e489dd7e58fac8e5004cf10e776 422 SUPERFAMILY SSF56954 3 419 1.83E-35 T 21-04-2016 SPH21_RS20270 9da22e489dd7e58fac8e5004cf10e776 422 Gene3D G3DSA:1.20.1600.10 24 419 2.7E-22 T 21-04-2016 SPH21_RS20270 9da22e489dd7e58fac8e5004cf10e776 422 Pfam PF02321 Outer membrane efflux protein 27 208 2.0E-10 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS20270 9da22e489dd7e58fac8e5004cf10e776 422 Pfam PF02321 Outer membrane efflux protein 276 419 5.2E-5 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS20270 9da22e489dd7e58fac8e5004cf10e776 422 PANTHER PTHR30026:SF4 1 419 5.9E-25 T 21-04-2016 SPH21_RS20270 9da22e489dd7e58fac8e5004cf10e776 422 PANTHER PTHR30026 1 419 5.9E-25 T 21-04-2016 SPH21_RS02205 ab15204fa2da490610f0ed81d893f1e0 396 Gene3D G3DSA:3.40.50.1970 11 189 7.9E-43 T 21-04-2016 SPH21_RS02205 ab15204fa2da490610f0ed81d893f1e0 396 Gene3D G3DSA:1.20.1090.10 190 376 3.2E-43 T 21-04-2016 SPH21_RS02205 ab15204fa2da490610f0ed81d893f1e0 396 Pfam PF01761 3-dehydroquinate synthase 83 331 2.9E-74 T 21-04-2016 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164|UniPathway: UPA00053 SPH21_RS02205 ab15204fa2da490610f0ed81d893f1e0 396 PANTHER PTHR21090 81 387 8.1E-78 T 21-04-2016 SPH21_RS02205 ab15204fa2da490610f0ed81d893f1e0 396 SUPERFAMILY SSF56796 9 376 5.63E-79 T 21-04-2016 SPH21_RS09415 483edba422a717bd750b5ec87dc80375 548 PANTHER PTHR35148 3 310 6.6E-37 T 21-04-2016 SPH21_RS09415 483edba422a717bd750b5ec87dc80375 548 PANTHER PTHR35148 351 547 6.6E-37 T 21-04-2016 SPH21_RS09415 483edba422a717bd750b5ec87dc80375 548 Pfam PF12771 Starch-binding associating with outer membrane 375 520 1.1E-20 T 21-04-2016 SPH21_RS09415 483edba422a717bd750b5ec87dc80375 548 Pfam PF12771 Starch-binding associating with outer membrane 12 305 3.9E-36 T 21-04-2016 SPH21_RS09415 483edba422a717bd750b5ec87dc80375 548 SUPERFAMILY SSF48452 22 310 1.19E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09415 483edba422a717bd750b5ec87dc80375 548 SUPERFAMILY SSF48452 347 521 1.19E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21465 c6528852a7afaee960d6d46959b721d2 330 Gene3D G3DSA:3.90.226.10 116 325 7.3E-35 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS21465 c6528852a7afaee960d6d46959b721d2 330 PANTHER PTHR11261 30 320 8.7E-27 T 21-04-2016 SPH21_RS21465 c6528852a7afaee960d6d46959b721d2 330 Pfam PF11918 N-terminal domain of Peptidase_S41 in eukaryotic IRBP 30 109 9.7E-8 T 21-04-2016 SPH21_RS21465 c6528852a7afaee960d6d46959b721d2 330 SUPERFAMILY SSF52096 29 323 1.36E-38 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS21465 c6528852a7afaee960d6d46959b721d2 330 SMART SM00245 79 311 1.6E-15 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS21465 c6528852a7afaee960d6d46959b721d2 330 Pfam PF03572 Peptidase family S41 140 308 3.9E-27 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS21465 c6528852a7afaee960d6d46959b721d2 330 Gene3D G3DSA:3.30.750.44 31 102 3.5E-6 T 21-04-2016 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 Pfam PF14520 Helix-hairpin-helix domain 8 56 4.8E-7 T 21-04-2016 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 SMART SM00278 7 26 8.5 T 21-04-2016 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 SMART SM00278 39 58 3.8 T 21-04-2016 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 Gene3D G3DSA:3.40.50.450 111 284 3.6E-11 T 21-04-2016 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 TIGRFAM TIGR00732 dprA: DNA protecting protein DprA 70 283 1.3E-69 T 21-04-2016 IPR003488 DNA recombination-mediator protein A GO:0009294 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 SUPERFAMILY SSF102405 80 284 1.5E-31 T 21-04-2016 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 PANTHER PTHR32039:SF8 64 362 3.1E-95 T 21-04-2016 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 Gene3D G3DSA:1.10.150.20 7 56 3.0E-11 T 21-04-2016 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 PANTHER PTHR32039 64 362 3.1E-95 T 21-04-2016 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 Pfam PF02481 DNA recombination-mediator protein A 72 277 1.6E-76 T 21-04-2016 IPR003488 DNA recombination-mediator protein A GO:0009294 SPH21_RS12515 636a6627f32421da426f50c761402d6f 364 SUPERFAMILY SSF47781 2 56 2.97E-11 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 PANTHER PTHR23105:SF5 21 229 1.2E-73 T 21-04-2016 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 PIRSF PIRSF002155 1 227 3.0E-70 T 21-04-2016 IPR002143 Ribosomal protein L1 GO:0003723|GO:0003735|GO:0006412|GO:0015934 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 Hamap MF_01318_B 50S ribosomal protein L1 [rplA]. 2 229 40.478 T 21-04-2016 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 SUPERFAMILY SSF56808 6 225 2.88E-77 T 21-04-2016 IPR023674 Ribosomal protein L1-like SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 TIGRFAM TIGR01169 rplA_bact: ribosomal protein uL1 4 228 4.8E-96 T 21-04-2016 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 Pfam PF00687 Ribosomal protein L1p/L10e family 31 220 5.2E-51 T 21-04-2016 IPR028364 Ribosomal protein L1/ribosomal biogenesis protein SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 PANTHER PTHR23105 21 229 1.2E-73 T 21-04-2016 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 Gene3D G3DSA:3.30.190.20 161 226 3.1E-44 T 21-04-2016 IPR016094 Ribosomal protein L1, 2-layer alpha/beta-sandwich GO:0003723 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 Gene3D G3DSA:3.30.190.20 18 68 3.1E-44 T 21-04-2016 IPR016094 Ribosomal protein L1, 2-layer alpha/beta-sandwich GO:0003723 SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 Gene3D G3DSA:3.40.50.790 69 159 1.0E-38 T 21-04-2016 IPR016095 Ribosomal protein L1, 3-layer alpha/beta-sandwich SPH21_RS11890 79e18f88b4e9f0ab4f603edb1b838ff5 232 ProSitePatterns PS01199 Ribosomal protein L1 signature. 121 139 - T 21-04-2016 IPR023673 Ribosomal protein L1, conserved site SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Pfam PF13715 CarboxypepD_reg-like domain 50 134 8.7E-19 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 PANTHER PTHR11532:SF57 524 1030 1.4E-245 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 PANTHER PTHR11532:SF57 46 448 1.4E-245 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Pfam PF07715 TonB-dependent Receptor Plug Domain 142 249 5.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 SUPERFAMILY SSF56935 453 794 5.13E-88 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 SUPERFAMILY SSF56935 130 273 5.13E-88 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 SUPERFAMILY SSF56935 938 969 5.13E-88 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 SUPERFAMILY SSF56935 335 423 5.13E-88 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 SUPERFAMILY SSF56935 859 903 5.13E-88 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Gene3D G3DSA:2.170.130.10 138 250 5.3E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 SUPERFAMILY SSF49464 50 146 7.72E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 225 255 5.6E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Gene3D G3DSA:2.60.40.1120 50 137 1.2E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Gene3D G3DSA:2.40.170.20 251 269 1.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Gene3D G3DSA:2.40.170.20 928 1032 1.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Gene3D G3DSA:2.40.170.20 868 893 1.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Gene3D G3DSA:2.40.170.20 344 812 1.2E-46 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 49 1032 9.9E-263 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 Pfam PF00593 TonB dependent receptor 628 1031 7.1E-18 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 PANTHER PTHR11532 524 1030 1.4E-245 T 21-04-2016 SPH21_RS13045 a34def28aa7df07109c8b85e9fb55cd0 1032 PANTHER PTHR11532 46 448 1.4E-245 T 21-04-2016 SPH21_RS16630 fa813f5a013b32b95ebedfab241baafd 282 Gene3D G3DSA:1.10.3210.10 3 222 9.3E-35 T 21-04-2016 IPR006674 HD domain SPH21_RS16630 fa813f5a013b32b95ebedfab241baafd 282 PANTHER PTHR11373 1 255 5.3E-62 T 21-04-2016 SPH21_RS16630 fa813f5a013b32b95ebedfab241baafd 282 SMART SM00471 45 158 1.0E-8 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS16630 fa813f5a013b32b95ebedfab241baafd 282 SUPERFAMILY SSF109604 4 277 1.19E-39 T 21-04-2016 SPH21_RS16630 fa813f5a013b32b95ebedfab241baafd 282 PANTHER PTHR11373:SF26 1 255 5.3E-62 T 21-04-2016 SPH21_RS16630 fa813f5a013b32b95ebedfab241baafd 282 Pfam PF01966 HD domain 49 126 3.1E-8 T 21-04-2016 IPR006674 HD domain SPH21_RS08000 bed9a9248488cf2e6c4912f647ef3850 716 SUPERFAMILY SSF50494 639 709 1.72E-28 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS08000 bed9a9248488cf2e6c4912f647ef3850 716 SUPERFAMILY SSF50494 178 288 1.72E-28 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS08000 bed9a9248488cf2e6c4912f647ef3850 716 SUPERFAMILY SSF50494 58 100 1.72E-28 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS08000 bed9a9248488cf2e6c4912f647ef3850 716 Gene3D G3DSA:2.40.10.10 611 695 1.2E-15 T 21-04-2016 SPH21_RS08000 bed9a9248488cf2e6c4912f647ef3850 716 PANTHER PTHR38469 3 716 3.3E-200 T 21-04-2016 SPH21_RS08000 bed9a9248488cf2e6c4912f647ef3850 716 Pfam PF10459 Peptidase S46 21 713 2.3E-243 T 21-04-2016 IPR019500 Peptidase S46 GO:0008239|GO:0070009 SPH21_RS08000 bed9a9248488cf2e6c4912f647ef3850 716 PANTHER PTHR38469:SF1 3 716 3.3E-200 T 21-04-2016 SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 Gene3D G3DSA:3.40.50.720 180 321 7.1E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 SUPERFAMILY SSF50129 1 183 7.7E-56 T 21-04-2016 IPR011032 GroES-like SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 59 73 - T 21-04-2016 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 SUPERFAMILY SSF51735 154 342 8.65E-53 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 PANTHER PTHR11695 12 256 4.7E-138 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 PANTHER PTHR11695 278 379 4.7E-138 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 PANTHER PTHR11695:SF281 12 256 4.7E-138 T 21-04-2016 SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 PANTHER PTHR11695:SF281 278 379 4.7E-138 T 21-04-2016 SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 Gene3D G3DSA:3.90.180.10 1 179 2.9E-52 T 21-04-2016 IPR011032 GroES-like SPH21_RS23185 f96ed91f136ef7d5d9ac9b24f33d5f01 384 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 142 1.3E-28 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 Gene3D G3DSA:1.10.10.60 294 340 6.0E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 PANTHER PTHR11019 240 347 7.6E-27 T 21-04-2016 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 Gene3D G3DSA:1.10.10.60 241 293 1.7E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 Pfam PF12833 Helix-turn-helix domain 263 341 2.4E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 SUPERFAMILY SSF46689 242 290 2.6E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 PANTHER PTHR11019:SF61 240 347 7.6E-27 T 21-04-2016 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 SUPERFAMILY SSF46689 293 342 3.18E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 294 335 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS00900 c9f0544a671171c0d3505b81f98b2f3a 361 SMART SM00342 257 339 3.0E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 SMART SM00986 50 211 1.6E-35 T 21-04-2016 IPR005122 Uracil-DNA glycosylase-like SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 Pfam PF03167 Uracil DNA glycosylase superfamily 56 210 1.3E-22 T 21-04-2016 IPR005122 Uracil-DNA glycosylase-like SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 TIGRFAM TIGR00628 ung: uracil-DNA glycosylase 7 216 1.2E-85 T 21-04-2016 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 PANTHER PTHR11264 1 223 1.8E-137 T 21-04-2016 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 Hamap MF_00148 Uracil-DNA glycosylase [ung]. 6 222 40.719 T 21-04-2016 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 ProSitePatterns PS00130 Uracil-DNA glycosylase signature. 58 67 - T 21-04-2016 IPR018085 Uracil-DNA glycosylase, active site GO:0006281|GO:0016799 SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 Gene3D G3DSA:3.40.470.10 5 222 1.5E-101 T 21-04-2016 IPR005122 Uracil-DNA glycosylase-like SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 SUPERFAMILY SSF52141 3 222 6.76E-95 T 21-04-2016 IPR005122 Uracil-DNA glycosylase-like SPH21_RS19905 cf9b05611a8408c3e652fec69a116a98 223 SMART SM00987 50 211 1.6E-35 T 21-04-2016 SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 SMART SM00347 24 126 2.7E-14 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 Gene3D G3DSA:1.10.10.10 3 135 6.1E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 SUPERFAMILY SSF46785 4 137 6.64E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 ProSitePatterns PS01117 MarR-type HTH domain signature. 62 96 - T 21-04-2016 IPR023187 Transcriptional regulator MarR-type, conserved site SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 PANTHER PTHR33164 7 145 3.4E-21 T 21-04-2016 SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 Pfam PF01047 MarR family 45 88 1.9E-10 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 PRINTS PR00598 Bacterial regulatory protein MarR family signature 47 63 1.7E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 PRINTS PR00598 Bacterial regulatory protein MarR family signature 64 79 1.7E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS00110 0f39a85d539b58fce40c1ad06fd5923f 145 PRINTS PR00598 Bacterial regulatory protein MarR family signature 83 99 1.7E-7 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 PRINTS PR00060 Ribosomal protein L16 signature 42 53 5.6E-38 T 21-04-2016 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 PRINTS PR00060 Ribosomal protein L16 signature 58 87 5.6E-38 T 21-04-2016 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 PRINTS PR00060 Ribosomal protein L16 signature 24 36 5.6E-38 T 21-04-2016 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 PRINTS PR00060 Ribosomal protein L16 signature 88 117 5.6E-38 T 21-04-2016 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 Gene3D G3DSA:3.90.1170.10 23 136 5.1E-56 T 21-04-2016 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 TIGRFAM TIGR01164 rplP_bact: ribosomal protein uL16 2 127 1.6E-60 T 21-04-2016 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 Hamap MF_01342 50S ribosomal protein L16 [rplP]. 1 134 40.94 T 21-04-2016 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 SUPERFAMILY SSF54686 1 136 1.96E-59 T 21-04-2016 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 Pfam PF00252 Ribosomal protein L16p/L10e 4 132 1.6E-51 T 21-04-2016 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 ProSitePatterns PS00586 Ribosomal protein L16 signature 1. 59 70 - T 21-04-2016 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 ProSitePatterns PS00701 Ribosomal protein L16 signature 2. 82 93 - T 21-04-2016 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08530 8b9c237267ac7431ac770b7d21d99654 140 PANTHER PTHR12220 1 139 3.4E-75 T 21-04-2016 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 SPH21_RS15935 668fae5c78f726c982ded546d7f15ff8 306 PIRSF PIRSF000812 9 296 2.1E-90 T 21-04-2016 IPR007530 Aminoglycoside 6-adenylyltransferase SPH21_RS15935 668fae5c78f726c982ded546d7f15ff8 306 Gene3D G3DSA:3.30.460.10 17 163 2.3E-51 T 21-04-2016 SPH21_RS15935 668fae5c78f726c982ded546d7f15ff8 306 SUPERFAMILY SSF81631 148 291 2.28E-47 T 21-04-2016 SPH21_RS15935 668fae5c78f726c982ded546d7f15ff8 306 Pfam PF04439 Streptomycin adenylyltransferase 10 290 2.2E-109 T 21-04-2016 IPR007530 Aminoglycoside 6-adenylyltransferase SPH21_RS15935 668fae5c78f726c982ded546d7f15ff8 306 SUPERFAMILY SSF81301 10 141 3.92E-39 T 21-04-2016 SPH21_RS15935 668fae5c78f726c982ded546d7f15ff8 306 Gene3D G3DSA:1.20.120.330 164 302 2.4E-45 T 21-04-2016 SPH21_RS13420 ec95f19a6970b89d2f83cb35c0f6502b 138 Pfam PF09413 Putative prokaryotic signal transducing protein 8 69 7.9E-12 T 21-04-2016 IPR018551 Domain of unknown function DUF2007 SPH21_RS13420 ec95f19a6970b89d2f83cb35c0f6502b 138 SUPERFAMILY SSF54913 7 71 2.45E-7 T 21-04-2016 IPR011322 Nitrogen regulatory PII-like, alpha/beta SPH21_RS13420 ec95f19a6970b89d2f83cb35c0f6502b 138 Gene3D G3DSA:3.30.70.790 11 70 3.8E-4 T 21-04-2016 IPR007864 Urease accessory protein UreE, C-terminal domain GO:0006461|GO:0016151|GO:0019627 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 ProSitePatterns PS00079 Multicopper oxidases signature 1. 149 169 - T 21-04-2016 IPR033138 Multicopper oxidases, conserved site SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 SUPERFAMILY SSF49503 257 380 5.42E-22 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 Gene3D G3DSA:2.60.40.420 511 652 6.3E-44 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 Gene3D G3DSA:2.60.40.420 45 172 3.3E-29 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 Pfam PF07732 Multicopper oxidase 61 175 6.3E-35 T 21-04-2016 IPR011707 Multicopper oxidase, type 3 GO:0005507 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 SUPERFAMILY SSF49503 533 645 1.31E-33 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 SUPERFAMILY SSF49503 39 177 8.25E-34 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 PANTHER PTHR11709 255 367 5.5E-76 T 21-04-2016 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 PANTHER PTHR11709 534 646 5.5E-76 T 21-04-2016 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 PANTHER PTHR11709 1 27 5.5E-76 T 21-04-2016 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 PANTHER PTHR11709 53 207 5.5E-76 T 21-04-2016 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 SUPERFAMILY SSF49503 179 213 5.42E-22 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 Pfam PF07731 Multicopper oxidase 533 646 3.5E-30 T 21-04-2016 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 Gene3D G3DSA:2.60.40.420 180 381 2.9E-27 T 21-04-2016 IPR008972 Cupredoxin SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 Pfam PF00394 Multicopper oxidase 183 347 6.0E-15 T 21-04-2016 IPR001117 Multicopper oxidase, type 1 GO:0016491|GO:0055114 SPH21_RS01375 749e9021ba7ae5239bc506f51c41f3d2 836 ProSitePatterns PS00080 Multicopper oxidases signature 2. 631 642 - T 21-04-2016 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 SPH21_RS07725 d5c4b50d45fa63bf1ebc3edb95356873 236 Pfam PF02630 SCO1/SenC 53 202 9.0E-9 T 21-04-2016 IPR003782 Copper chaperone SCO1/SenC SPH21_RS07725 d5c4b50d45fa63bf1ebc3edb95356873 236 SUPERFAMILY SSF52833 69 226 1.12E-17 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07725 d5c4b50d45fa63bf1ebc3edb95356873 236 Gene3D G3DSA:3.40.30.10 19 27 2.2E-23 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07725 d5c4b50d45fa63bf1ebc3edb95356873 236 Gene3D G3DSA:3.40.30.10 63 227 2.2E-23 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Pfam PF07730 Histidine kinase 583 649 9.4E-11 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 SMART SM00387 686 778 2.6E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 SUPERFAMILY SSF55785 25 138 5.33E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Gene3D G3DSA:3.30.565.10 653 779 5.9E-13 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 688 777 1.1E-8 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 SUPERFAMILY SSF55785 283 400 1.49E-9 T 21-04-2016 IPR000014 PAS domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 422 552 5.9E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Pfam PF13188 PAS domain 34 98 0.0021 T 21-04-2016 IPR000014 PAS domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 PANTHER PTHR24421:SF23 274 775 2.3E-39 T 21-04-2016 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 SMART SM00086 504 547 9.4E-6 T 21-04-2016 IPR001610 PAC motif SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 PANTHER PTHR24421 274 775 2.3E-39 T 21-04-2016 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 SUPERFAMILY SSF55785 410 545 2.62E-15 T 21-04-2016 IPR000014 PAS domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 SUPERFAMILY SSF55874 667 775 2.1E-18 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Gene3D G3DSA:3.30.450.20 409 555 1.2E-25 T 21-04-2016 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Pfam PF08447 PAS fold 449 540 9.6E-10 T 21-04-2016 IPR013655 PAS fold-3 GO:0005515 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 PRINTS PR00344 Bacterial sensor protein C-terminal signature 738 756 1.2E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 PRINTS PR00344 Bacterial sensor protein C-terminal signature 722 736 1.2E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 PRINTS PR00344 Bacterial sensor protein C-terminal signature 762 775 1.2E-5 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 SUPERFAMILY SSF55785 206 296 2.09E-5 T 21-04-2016 IPR000014 PAS domain SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Gene3D G3DSA:3.30.450.20 29 148 1.8E-10 T 21-04-2016 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Gene3D G3DSA:3.30.450.20 168 287 1.3E-8 T 21-04-2016 SPH21_RS18535 2af5073f5b065226224343175f4d907a 781 Gene3D G3DSA:3.30.450.20 288 408 9.7E-12 T 21-04-2016 SPH21_RS18825 3182372f14ff6479c7553c4b24181e7f 332 PANTHER PTHR12526 204 329 1.8E-18 T 21-04-2016 SPH21_RS18825 3182372f14ff6479c7553c4b24181e7f 332 SUPERFAMILY SSF53756 204 316 2.2E-20 T 21-04-2016 SPH21_RS18825 3182372f14ff6479c7553c4b24181e7f 332 Pfam PF00534 Glycosyl transferases group 1 204 295 1.1E-8 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS18825 3182372f14ff6479c7553c4b24181e7f 332 Gene3D G3DSA:3.40.50.2000 203 295 7.1E-6 T 21-04-2016 SPH21_RS18825 3182372f14ff6479c7553c4b24181e7f 332 PANTHER PTHR12526:SF374 204 329 1.8E-18 T 21-04-2016 SPH21_RS06365 85d037907b5ee4edb9f6100581d48e5a 230 Pfam PF04298 Putative neutral zinc metallopeptidase 5 224 4.3E-89 T 21-04-2016 IPR007395 Putative neutral zinc metallopeptidase SPH21_RS06365 85d037907b5ee4edb9f6100581d48e5a 230 PANTHER PTHR36434 1 230 1.9E-85 T 21-04-2016 SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 SMART SM00471 479 636 4.7E-10 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 Pfam PF07698 7TM receptor with intracellular HD hydrolase 273 458 8.2E-28 T 21-04-2016 IPR011621 Metal-dependent phosphohydrolase, 7TM intracellular domain SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 SUPERFAMILY SSF109604 478 680 5.32E-17 T 21-04-2016 SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 PANTHER PTHR36442 166 687 1.1E-135 T 21-04-2016 SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 TIGRFAM TIGR00277 HDIG: HDIG domain 481 578 2.8E-25 T 21-04-2016 IPR006675 HDIG domain SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 Pfam PF07697 7TM-HD extracellular 53 256 2.9E-14 T 21-04-2016 IPR011624 Metal-dependent phosphohydrolase, 7TM extracellular domain SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 Gene3D G3DSA:1.10.3210.10 465 654 1.5E-24 T 21-04-2016 IPR006674 HD domain SPH21_RS12265 bea55a1979798a65290c614d9b81cfef 696 Pfam PF01966 HD domain 483 626 4.4E-15 T 21-04-2016 IPR006674 HD domain SPH21_RS09110 381f0379eaeebc90ce5003f9599cf012 312 ProSitePatterns PS01173 Lipolytic enzymes "G-D-X-G" family, putative histidine active site. 77 93 - T 21-04-2016 IPR002168 Lipase, GDXG, putative histidine active site GO:0008152|GO:0016787 SPH21_RS09110 381f0379eaeebc90ce5003f9599cf012 312 SUPERFAMILY SSF53474 47 311 1.64E-67 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS09110 381f0379eaeebc90ce5003f9599cf012 312 Pfam PF07859 alpha/beta hydrolase fold 78 284 4.6E-67 T 21-04-2016 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SPH21_RS09110 381f0379eaeebc90ce5003f9599cf012 312 PANTHER PTHR23024 29 312 6.5E-90 T 21-04-2016 SPH21_RS09110 381f0379eaeebc90ce5003f9599cf012 312 PANTHER PTHR23024:SF128 29 312 6.5E-90 T 21-04-2016 SPH21_RS09110 381f0379eaeebc90ce5003f9599cf012 312 Gene3D G3DSA:3.40.50.1820 1 311 8.4E-89 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 PRINTS PR00775 90kDa heat shock protein signature 6 26 6.7E-6 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 PRINTS PR00775 90kDa heat shock protein signature 156 173 6.7E-6 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 PRINTS PR00775 90kDa heat shock protein signature 27 49 6.7E-6 T 21-04-2016 IPR020575 Heat shock protein Hsp90, N-terminal SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 PANTHER PTHR11528:SF26 10 595 3.5E-51 T 21-04-2016 SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 27 140 3.1E-11 T 21-04-2016 SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 Gene3D G3DSA:3.30.565.10 7 211 3.4E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 PIRSF PIRSF002583 1 591 2.1E-88 T 21-04-2016 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 Pfam PF00183 Hsp90 protein 260 588 1.8E-14 T 21-04-2016 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 SUPERFAMILY SSF55874 6 195 2.44E-36 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 PANTHER PTHR11528 10 595 3.5E-51 T 21-04-2016 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SPH21_RS13975 b81b0214b999b0aa64c206b13289e93c 595 SUPERFAMILY SSF54211 213 430 3.57E-34 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS23035 32af717ff5257ceb02940af4af3f381a 221 PANTHER PTHR10146 19 221 2.9E-87 T 21-04-2016 IPR011078 Uncharacterised protein family UPF0001 SPH21_RS23035 32af717ff5257ceb02940af4af3f381a 221 ProSitePatterns PS01211 Uncharacterized protein family UPF0001 signature. 65 79 - T 21-04-2016 IPR011078 Uncharacterised protein family UPF0001 SPH21_RS23035 32af717ff5257ceb02940af4af3f381a 221 TIGRFAM TIGR00044 TIGR00044: pyridoxal phosphate enzyme, YggS family 12 221 1.3E-62 T 21-04-2016 IPR011078 Uncharacterised protein family UPF0001 SPH21_RS23035 32af717ff5257ceb02940af4af3f381a 221 SUPERFAMILY SSF51419 2 219 3.14E-72 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS23035 32af717ff5257ceb02940af4af3f381a 221 PIRSF PIRSF004848 1 221 7.6E-75 T 21-04-2016 IPR011078 Uncharacterised protein family UPF0001 SPH21_RS23035 32af717ff5257ceb02940af4af3f381a 221 Pfam PF01168 Alanine racemase, N-terminal domain 3 220 1.1E-20 T 21-04-2016 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23035 32af717ff5257ceb02940af4af3f381a 221 Gene3D G3DSA:3.20.20.10 3 221 1.1E-78 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS26330 705a65978a03d70e52b5881bdf3f7525 155 PANTHER PTHR37302 33 154 1.8E-12 T 21-04-2016 SPH21_RS26330 705a65978a03d70e52b5881bdf3f7525 155 Gene3D G3DSA:1.20.120.450 34 152 4.7E-20 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS26330 705a65978a03d70e52b5881bdf3f7525 155 SUPERFAMILY SSF109854 35 145 5.86E-17 T 21-04-2016 SPH21_RS26330 705a65978a03d70e52b5881bdf3f7525 155 PANTHER PTHR37302:SF1 33 154 1.8E-12 T 21-04-2016 SPH21_RS26330 705a65978a03d70e52b5881bdf3f7525 155 Pfam PF05163 DinB family 36 153 6.9E-14 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS18755 245e791bbd0e5da2079d799813f6961a 283 PANTHER PTHR24220 3 216 2.8E-73 T 21-04-2016 SPH21_RS18755 245e791bbd0e5da2079d799813f6961a 283 SMART SM00382 26 197 2.5E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS18755 245e791bbd0e5da2079d799813f6961a 283 Gene3D G3DSA:3.40.50.300 5 219 1.3E-58 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18755 245e791bbd0e5da2079d799813f6961a 283 Pfam PF00005 ABC transporter 17 150 1.2E-26 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS18755 245e791bbd0e5da2079d799813f6961a 283 PANTHER PTHR24220:SF523 3 216 2.8E-73 T 21-04-2016 SPH21_RS18755 245e791bbd0e5da2079d799813f6961a 283 ProSitePatterns PS00211 ABC transporters family signature. 123 137 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS18755 245e791bbd0e5da2079d799813f6961a 283 SUPERFAMILY SSF52540 3 214 1.25E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 PANTHER PTHR18968:SF12 1 571 3.6E-265 T 21-04-2016 SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 191 318 2.3E-29 T 21-04-2016 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 SUPERFAMILY SSF52467 181 350 1.5E-40 T 21-04-2016 IPR029035 DHS-like NAD/FAD-binding domain SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 4 168 2.0E-35 T 21-04-2016 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 Gene3D G3DSA:3.40.50.970 354 560 2.4E-58 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 Gene3D G3DSA:3.40.50.970 2 167 3.1E-45 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 Gene3D G3DSA:3.40.50.1220 184 341 2.8E-38 T 21-04-2016 IPR029035 DHS-like NAD/FAD-binding domain SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 PANTHER PTHR18968 1 571 3.6E-265 T 21-04-2016 SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 SUPERFAMILY SSF52518 4 167 5.44E-40 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 SUPERFAMILY SSF52518 356 564 1.68E-58 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 380 525 1.2E-38 T 21-04-2016 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SPH21_RS10850 4dc2d49e4e514b84f073e6458372a53f 578 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 417 436 - T 21-04-2016 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SPH21_RS14135 75e6c92ff4519cee9f7f988e40644951 516 SUPERFAMILY SSF48452 29 514 8.23E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14135 75e6c92ff4519cee9f7f988e40644951 516 Pfam PF14322 Starch-binding associating with outer membrane 34 231 8.1E-21 T 21-04-2016 SPH21_RS14135 75e6c92ff4519cee9f7f988e40644951 516 Pfam PF07980 SusD family 274 514 8.6E-38 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14135 75e6c92ff4519cee9f7f988e40644951 516 Gene3D G3DSA:1.25.40.10 365 449 5.9E-45 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14135 75e6c92ff4519cee9f7f988e40644951 516 Gene3D G3DSA:1.25.40.10 214 322 5.9E-45 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Gene3D G3DSA:3.30.565.10 740 906 1.4E-44 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SUPERFAMILY SSF55874 729 899 1.44E-45 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SUPERFAMILY SSF55781 405 574 2.35E-11 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SUPERFAMILY SSF52172 962 1073 9.68E-20 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Pfam PF13185 GAF domain 441 574 4.0E-11 T 21-04-2016 IPR003018 GAF domain GO:0005515 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SMART SM00448 960 1070 2.4E-13 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SMART SM00448 1082 1196 2.4E-4 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SMART SM00448 1228 1343 1.2E-37 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Pfam PF00512 His Kinase A (phospho-acceptor) domain 673 740 4.1E-17 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Gene3D G3DSA:3.30.450.40 440 575 1.5E-10 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SMART SM00387 787 901 7.3E-38 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Gene3D G3DSA:3.40.50.2300 962 1073 2.0E-21 T 21-04-2016 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Pfam PF00072 Response regulator receiver domain 963 1068 3.7E-14 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Pfam PF00072 Response regulator receiver domain 1230 1343 7.4E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Pfam PF00072 Response regulator receiver domain 1084 1186 5.9E-11 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 788 900 2.3E-27 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SUPERFAMILY SSF52172 1226 1347 6.69E-38 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SUPERFAMILY SSF47384 659 742 9.22E-20 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Gene3D G3DSA:1.10.287.130 664 736 1.5E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SMART SM00388 672 740 2.2E-20 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PANTHER PTHR24423 514 553 9.4E-138 T 21-04-2016 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PANTHER PTHR24423 32 39 9.4E-138 T 21-04-2016 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PANTHER PTHR24423 623 639 9.4E-138 T 21-04-2016 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PANTHER PTHR24423 1205 1349 9.4E-138 T 21-04-2016 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PANTHER PTHR24423 668 904 9.4E-138 T 21-04-2016 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 SUPERFAMILY SSF52172 1077 1200 6.26E-16 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Gene3D G3DSA:3.40.50.2300 1081 1196 2.6E-16 T 21-04-2016 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 844 854 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 826 840 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 885 898 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 PRINTS PR00344 Bacterial sensor protein C-terminal signature 861 879 7.9E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05475 744ff04abae9508cfd81e9bb2f0dabcf 1349 Gene3D G3DSA:3.40.50.2300 1226 1347 1.0E-40 T 21-04-2016 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 Gene3D G3DSA:1.10.260.30 326 427 5.9E-38 T 21-04-2016 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 Gene3D G3DSA:1.20.120.140 2 88 1.4E-29 T 21-04-2016 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 TIGRFAM TIGR00959 ffh: signal recognition particle protein 2 425 2.0E-184 T 21-04-2016 IPR004780 Signal recognition particle protein Ffh GO:0003924|GO:0005525|GO:0006614|GO:0048500 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 Gene3D G3DSA:3.40.50.300 97 296 1.7E-78 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 Pfam PF02978 Signal peptide binding domain 326 423 2.6E-33 T 21-04-2016 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 PANTHER PTHR11564:SF7 1 439 2.3E-248 T 21-04-2016 IPR004780 Signal recognition particle protein Ffh GO:0003924|GO:0005525|GO:0006614|GO:0048500 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 Pfam PF00448 SRP54-type protein, GTPase domain 99 295 3.9E-77 T 21-04-2016 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 SMART SM00962 99 295 8.5E-118 T 21-04-2016 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 Pfam PF02881 SRP54-type protein, helical bundle domain 5 82 4.7E-19 T 21-04-2016 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 Hamap MF_00306 Signal recognition particle 54 kDa protein [srp54]. 5 436 33.472 T 21-04-2016 IPR022941 Signal recognition particle, SRP54 subunit GO:0003924|GO:0005525|GO:0006614|GO:0048500 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 SMART SM00963 1 86 8.3E-29 T 21-04-2016 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 PANTHER PTHR11564 1 439 2.3E-248 T 21-04-2016 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 SUPERFAMILY SSF52540 42 353 1.91E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 SMART SM00382 98 300 9.6E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 SUPERFAMILY SSF47446 326 426 4.58E-36 T 21-04-2016 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 SPH21_RS07100 70377521eaebc8f32c8d8df3a25091e3 446 ProSitePatterns PS00300 SRP54-type proteins GTP-binding domain signature. 268 281 - T 21-04-2016 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 SUPERFAMILY SSF51735 28 193 2.73E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 PANTHER PTHR22604 1 405 1.5E-90 T 21-04-2016 SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 Gene3D G3DSA:3.40.50.720 32 178 1.4E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 Gene3D G3DSA:3.30.360.10 309 397 1.5E-7 T 21-04-2016 SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 Gene3D G3DSA:3.30.360.10 179 272 3.7E-9 T 21-04-2016 SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 PANTHER PTHR22604:SF122 1 405 1.5E-90 T 21-04-2016 SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 38 164 6.1E-19 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 SUPERFAMILY SSF55347 173 199 9.37E-14 T 21-04-2016 SPH21_RS25080 a47b34a05de5360332b2b02e57bae337 425 SUPERFAMILY SSF55347 235 375 9.37E-14 T 21-04-2016 SPH21_RS12945 589a31dd85f1cd4f88b7c870abd615c0 99 PANTHER PTHR31435 12 98 2.3E-14 T 21-04-2016 SPH21_RS12945 589a31dd85f1cd4f88b7c870abd615c0 99 Pfam PF14542 GCN5-related N-acetyl-transferase 17 92 1.1E-23 T 21-04-2016 IPR031165 Yjdj-type Gcn5-related N-acetyltransferase SPH21_RS12945 589a31dd85f1cd4f88b7c870abd615c0 99 Gene3D G3DSA:3.40.630.30 10 95 6.2E-28 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12945 589a31dd85f1cd4f88b7c870abd615c0 99 SUPERFAMILY SSF55729 11 89 2.03E-21 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS19465 a412b72e0cf732fdf3db9d5a70e87395 396 SUPERFAMILY SSF53383 11 392 7.8E-116 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS19465 a412b72e0cf732fdf3db9d5a70e87395 396 Gene3D G3DSA:3.90.1150.10 289 394 2.2E-28 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS19465 a412b72e0cf732fdf3db9d5a70e87395 396 Pfam PF00202 Aminotransferase class-III 17 389 1.3E-105 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS19465 a412b72e0cf732fdf3db9d5a70e87395 396 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216 253 - T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS19465 a412b72e0cf732fdf3db9d5a70e87395 396 Gene3D G3DSA:3.40.640.10 56 288 4.4E-83 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS19465 a412b72e0cf732fdf3db9d5a70e87395 396 PANTHER PTHR11986 24 394 1.9E-137 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS16325 ed51d4645e44e355b0e8bdf7116828f6 324 Gene3D G3DSA:3.40.50.2300 170 295 2.7E-31 T 21-04-2016 SPH21_RS16325 ed51d4645e44e355b0e8bdf7116828f6 324 PANTHER PTHR35271 1 321 2.7E-27 T 21-04-2016 SPH21_RS16325 ed51d4645e44e355b0e8bdf7116828f6 324 Gene3D G3DSA:3.40.50.2300 28 169 3.0E-25 T 21-04-2016 SPH21_RS16325 ed51d4645e44e355b0e8bdf7116828f6 324 SUPERFAMILY SSF53822 167 290 8.48E-10 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS16325 ed51d4645e44e355b0e8bdf7116828f6 324 Pfam PF04392 ABC transporter substrate binding protein 31 321 5.6E-48 T 21-04-2016 IPR007487 ABC transporter, substrate-binding protein SPH21_RS15000 5cf2b956cf89c99e68708d8aacd8b4f4 89 Pfam PF04066 Multiple resistance and pH regulation protein F (MrpF / PhaF) 33 84 9.2E-14 T 21-04-2016 IPR007208 Na(+)/H(+) antiporter subunit F-like GO:0015075|GO:0016021|GO:0034220 SPH21_RS15000 5cf2b956cf89c99e68708d8aacd8b4f4 89 PANTHER PTHR34702 1 88 1.2E-16 T 21-04-2016 SPH21_RS15000 5cf2b956cf89c99e68708d8aacd8b4f4 89 PANTHER PTHR34702:SF1 1 88 1.2E-16 T 21-04-2016 SPH21_RS05895 5949559d85542a6347217a8d6ea15096 800 PANTHER PTHR30572:SF4 403 800 5.1E-52 T 21-04-2016 SPH21_RS05895 5949559d85542a6347217a8d6ea15096 800 PANTHER PTHR30572:SF4 9 357 5.1E-52 T 21-04-2016 SPH21_RS05895 5949559d85542a6347217a8d6ea15096 800 Pfam PF02687 FtsX-like permease family 291 397 7.0E-18 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05895 5949559d85542a6347217a8d6ea15096 800 Pfam PF02687 FtsX-like permease family 681 793 6.4E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05895 5949559d85542a6347217a8d6ea15096 800 PANTHER PTHR30572 403 800 5.1E-52 T 21-04-2016 SPH21_RS05895 5949559d85542a6347217a8d6ea15096 800 PANTHER PTHR30572 9 357 5.1E-52 T 21-04-2016 SPH21_RS05895 5949559d85542a6347217a8d6ea15096 800 Pfam PF12704 MacB-like periplasmic core domain 20 247 3.4E-19 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS02290 76208d2b895d9335ae3e1eb98a119f24 435 PANTHER PTHR22604:SF92 7 408 3.0E-93 T 21-04-2016 SPH21_RS02290 76208d2b895d9335ae3e1eb98a119f24 435 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 46 172 5.4E-15 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS02290 76208d2b895d9335ae3e1eb98a119f24 435 Gene3D G3DSA:3.30.360.10 198 399 5.2E-31 T 21-04-2016 SPH21_RS02290 76208d2b895d9335ae3e1eb98a119f24 435 Gene3D G3DSA:3.40.50.720 43 197 1.3E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02290 76208d2b895d9335ae3e1eb98a119f24 435 SUPERFAMILY SSF55347 191 368 5.89E-24 T 21-04-2016 SPH21_RS02290 76208d2b895d9335ae3e1eb98a119f24 435 SUPERFAMILY SSF51735 39 208 8.02E-33 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02290 76208d2b895d9335ae3e1eb98a119f24 435 PANTHER PTHR22604 7 408 3.0E-93 T 21-04-2016 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 Pfam PF02689 Helicase 358 427 2.1E-4 T 21-04-2016 IPR003840 DNA helicase GO:0004386|GO:0005524 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 SUPERFAMILY SSF52540 133 428 8.18E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 SMART SM00341 620 700 4.2E-5 T 21-04-2016 IPR002121 HRDC domain GO:0003676|GO:0005622 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 Pfam PF00570 HRDC domain 626 690 4.3E-12 T 21-04-2016 IPR002121 HRDC domain GO:0003676|GO:0005622 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 Gene3D G3DSA:3.40.50.300 11 130 6.9E-8 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 SUPERFAMILY SSF47819 623 694 4.8E-13 T 21-04-2016 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 SUPERFAMILY SSF52540 2 209 2.92E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 Pfam PF05970 PIF1-like helicase 15 212 2.4E-27 T 21-04-2016 IPR010285 DNA helicase Pif1-like GO:0000723|GO:0003678|GO:0006281 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 PANTHER PTHR23274 8 515 1.2E-103 T 21-04-2016 IPR003840 DNA helicase GO:0004386|GO:0005524 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 Gene3D G3DSA:1.10.150.80 632 697 4.8E-7 T 21-04-2016 IPR002121 HRDC domain GO:0003676|GO:0005622 SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 Gene3D G3DSA:3.40.50.300 135 256 1.4E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25145 a8a596878d210ca232192692aab17b38 701 Gene3D G3DSA:3.40.50.300 353 414 1.4E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01345 c58300eab33d82c05a253f9e85e5b480 205 Pfam PF03713 Domain of unknown function (DUF305) 59 198 1.6E-29 T 21-04-2016 IPR005183 Domain of unknown function DUF305 SPH21_RS01345 c58300eab33d82c05a253f9e85e5b480 205 PANTHER PTHR36933 37 199 2.6E-16 T 21-04-2016 SPH21_RS01345 c58300eab33d82c05a253f9e85e5b480 205 PANTHER PTHR36933:SF1 37 199 2.6E-16 T 21-04-2016 SPH21_RS01345 c58300eab33d82c05a253f9e85e5b480 205 Gene3D G3DSA:1.20.1260.10 118 199 4.3E-19 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS01345 c58300eab33d82c05a253f9e85e5b480 205 Gene3D G3DSA:1.20.1260.10 28 111 1.3E-17 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS24265 98f5271435f19cd39c5425bd92c02ca2 191 SUPERFAMILY SSF47413 19 82 3.97E-6 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS24265 98f5271435f19cd39c5425bd92c02ca2 191 Gene3D G3DSA:1.10.260.40 11 77 8.6E-7 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS19425 0bceb685dee979ee1b0e145ab640c01f 203 SUPERFAMILY SSF56529 2 202 3.53E-63 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS19425 0bceb685dee979ee1b0e145ab640c01f 203 PANTHER PTHR11820 2 194 4.0E-75 T 21-04-2016 SPH21_RS19425 0bceb685dee979ee1b0e145ab640c01f 203 Gene3D G3DSA:3.90.850.10 2 202 4.8E-69 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS19425 0bceb685dee979ee1b0e145ab640c01f 203 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 2 192 9.4E-42 T 21-04-2016 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 71 287 1.1E-39 T 21-04-2016 IPR003741 LUD domain SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 Pfam PF13183 4Fe-4S dicluster domain 304 369 1.2E-12 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 SUPERFAMILY SSF46548 296 391 9.94E-18 T 21-04-2016 IPR009051 Alpha-helical ferredoxin GO:0051536 SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 Gene3D G3DSA:3.40.50.10420 188 287 6.2E-34 T 21-04-2016 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 Gene3D G3DSA:3.40.50.10420 63 126 6.2E-34 T 21-04-2016 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 Gene3D G3DSA:1.10.1060.10 293 392 4.5E-15 T 21-04-2016 SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 306 317 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 PANTHER PTHR32479:SF10 24 457 7.6E-188 T 21-04-2016 SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 PANTHER PTHR32479 24 457 7.6E-188 T 21-04-2016 SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 SUPERFAMILY SSF100950 63 87 8.37E-29 T 21-04-2016 SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 SUPERFAMILY SSF100950 133 288 8.37E-29 T 21-04-2016 SPH21_RS03275 f27aadcee4bb808b3eebe3e17be3151e 457 Pfam PF11870 Domain of unknown function (DUF3390) 389 456 7.4E-9 T 21-04-2016 IPR024569 4Fe-4S binding protein, C-terminal SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 Gene3D G3DSA:2.40.50.40 142 207 9.1E-13 T 21-04-2016 SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 SMART SM00850 149 243 1.2E-15 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 Pfam PF00072 Response regulator receiver domain 3 111 1.4E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 PANTHER PTHR26402:SF522 1 115 7.2E-30 T 21-04-2016 SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 SUPERFAMILY SSF52172 1 123 1.41E-28 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 Gene3D G3DSA:3.40.50.2300 1 118 2.2E-28 T 21-04-2016 SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 PANTHER PTHR26402 1 115 7.2E-30 T 21-04-2016 SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 SMART SM00448 1 110 7.4E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03430 b1cfbdf9518c970509a5a613b5c1f799 246 Pfam PF04397 LytTr DNA-binding domain 150 242 4.5E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 Gene3D G3DSA:3.40.50.300 1 236 1.1E-76 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 Pfam PF00005 ABC transporter 18 162 1.4E-34 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 PANTHER PTHR24220:SF434 3 241 5.7E-124 T 21-04-2016 SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 PANTHER PTHR24220:SF434 258 293 5.7E-124 T 21-04-2016 SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 PANTHER PTHR24220 3 241 5.7E-124 T 21-04-2016 SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 PANTHER PTHR24220 258 293 5.7E-124 T 21-04-2016 SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 SMART SM00382 26 212 4.0E-15 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 SUPERFAMILY SSF52540 1 238 1.33E-73 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12735 52ff5b4d2eac68d847a9a3c22ede4f19 319 ProSitePatterns PS00211 ABC transporters family signature. 135 149 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Pfam PF01751 Toprim domain 430 540 1.6E-18 T 21-04-2016 IPR006171 Toprim domain SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Gene3D G3DSA:3.30.230.10 231 403 4.9E-72 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Pfam PF00204 DNA gyrase B 232 401 3.0E-61 T 21-04-2016 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 SUPERFAMILY SSF55874 11 218 1.81E-72 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 ProSitePatterns PS00177 DNA topoisomerase II signature. 433 441 - T 21-04-2016 IPR018522 DNA topoisomerase, type IIA, conserved site GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PANTHER PTHR10169 4 647 1.5E-292 T 21-04-2016 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 TIGRFAM TIGR01059 gyrB: DNA gyrase, B subunit 11 651 2.2E-292 T 21-04-2016 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Gene3D G3DSA:3.40.50.670 415 634 7.0E-93 T 21-04-2016 IPR013759 DNA topoisomerase, type IIA, central domain GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 39 178 6.8E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 SUPERFAMILY SSF56719 405 645 2.41E-87 T 21-04-2016 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 585 601 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 118 132 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 520 537 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 431 445 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 502 518 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 279 292 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 40 55 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 75 88 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR00418 DNA topoisomerase II family signature 540 552 4.4E-68 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Hamap MF_01898 DNA gyrase subunit B [gyrB]. 8 652 88.106 T 21-04-2016 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 186 201 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 371 385 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 481 490 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 11 21 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 606 618 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 385 405 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 201 214 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 323 339 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 622 638 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 PRINTS PR01159 DNA gyrase subunit B signature 231 253 1.5E-65 T 21-04-2016 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 SMART SM00433 40 646 0.0 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Pfam PF00986 DNA gyrase B subunit, carboxyl terminus 581 642 1.7E-30 T 21-04-2016 IPR002288 DNA gyrase B subunit, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 SMART SM00387 36 180 1.8E-25 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 SUPERFAMILY SSF54211 232 402 4.74E-61 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS12170 7e53d05030073f2dfd2f63bafe805424 652 Gene3D G3DSA:3.30.565.10 11 220 1.9E-90 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20960 9eb2a43b70285de48fb6765054b62357 397 Pfam PF16344 Domain of unknown function (DUF4974) 296 394 1.7E-18 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS20960 9eb2a43b70285de48fb6765054b62357 397 Pfam PF04773 FecR protein 190 284 2.4E-20 T 21-04-2016 IPR006860 FecR protein SPH21_RS20960 9eb2a43b70285de48fb6765054b62357 397 PANTHER PTHR30273:SF2 1 133 9.6E-69 T 21-04-2016 SPH21_RS20960 9eb2a43b70285de48fb6765054b62357 397 PANTHER PTHR30273:SF2 192 397 9.6E-69 T 21-04-2016 SPH21_RS20960 9eb2a43b70285de48fb6765054b62357 397 PANTHER PTHR30273 1 133 9.6E-69 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS20960 9eb2a43b70285de48fb6765054b62357 397 PANTHER PTHR30273 192 397 9.6E-69 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 50 359 1.3E-105 T 21-04-2016 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198|UniPathway: UPA00072 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 TIGRFAM TIGR03699 menaquin_MqnC: dehypoxanthine futalosine cyclase 16 359 6.5E-130 T 21-04-2016 IPR022431 Cyclic dehypoxanthine futalosine synthase GO:0009234 KEGG: 00130+1.21.98.1|MetaCyc: PWY-7371|MetaCyc: PWY-7374|UniPathway: UPA00079 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 SUPERFAMILY SSF102114 16 317 4.71E-46 T 21-04-2016 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 PANTHER PTHR22976 3 373 1.5E-138 T 21-04-2016 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 SMART SM00729 54 282 0.0077 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 Pfam PF04055 Radical SAM superfamily 58 228 1.3E-12 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 Gene3D G3DSA:3.20.20.70 16 352 1.4E-60 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 PANTHER PTHR22976:SF29 3 373 1.5E-138 T 21-04-2016 SPH21_RS15190 730c1a3fbf8f78b75889ed4bb475bc1f 374 PIRSF PIRSF004762 1 372 8.4E-91 T 21-04-2016 IPR005244 FO synthase, subunit 2-like GO:0016765|GO:0051188|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198|UniPathway: UPA00072 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 Gene3D G3DSA:1.10.10.10 135 228 6.8E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 SMART SM00862 154 228 3.9E-14 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 Gene3D G3DSA:3.40.50.2300 2 124 1.2E-38 T 21-04-2016 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 SUPERFAMILY SSF46894 137 229 2.75E-18 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 SMART SM00448 2 114 6.8E-38 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 Pfam PF00486 Transcriptional regulatory protein, C terminal 154 228 2.5E-16 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 Pfam PF00072 Response regulator receiver domain 4 114 5.5E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 PANTHER PTHR26402 2 228 4.0E-74 T 21-04-2016 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 PANTHER PTHR26402:SF606 2 228 4.0E-74 T 21-04-2016 SPH21_RS06565 2f1e91aa093d8b27afd0638fafa3a831 231 SUPERFAMILY SSF52172 1 126 3.13E-37 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS18090 79e537ddc0b7009bf893a410080b4fec 443 PANTHER PTHR30026:SF4 23 440 3.9E-44 T 21-04-2016 SPH21_RS18090 79e537ddc0b7009bf893a410080b4fec 443 PANTHER PTHR30026 23 440 3.9E-44 T 21-04-2016 SPH21_RS18090 79e537ddc0b7009bf893a410080b4fec 443 Pfam PF02321 Outer membrane efflux protein 36 219 8.9E-25 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS18090 79e537ddc0b7009bf893a410080b4fec 443 Pfam PF02321 Outer membrane efflux protein 261 438 4.2E-21 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS18090 79e537ddc0b7009bf893a410080b4fec 443 SUPERFAMILY SSF56954 2 439 8.5E-74 T 21-04-2016 SPH21_RS18090 79e537ddc0b7009bf893a410080b4fec 443 Gene3D G3DSA:1.20.1600.10 31 439 4.3E-67 T 21-04-2016 SPH21_RS05540 7b9122adf6dc41145be566aa0e01f007 517 Pfam PF10150 Ribonuclease E/G family 144 414 4.3E-98 T 21-04-2016 IPR019307 RNA-binding protein AU-1/Ribonuclease E/G GO:0003723 SPH21_RS05540 7b9122adf6dc41145be566aa0e01f007 517 PANTHER PTHR30001 3 515 1.0E-157 T 21-04-2016 SPH21_RS05540 7b9122adf6dc41145be566aa0e01f007 517 SUPERFAMILY SSF50249 40 148 1.61E-13 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05540 7b9122adf6dc41145be566aa0e01f007 517 TIGRFAM TIGR00757 RNaseEG: ribonuclease, Rne/Rng family 15 443 4.4E-134 T 21-04-2016 IPR004659 Ribonuclease E/G GO:0003723|GO:0004540|GO:0006396 SPH21_RS05540 7b9122adf6dc41145be566aa0e01f007 517 Gene3D G3DSA:2.40.50.140 32 148 3.1E-23 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS10265 177dc4a652188bcefba9f8b4bf276859 287 SUPERFAMILY SSF51735 1 282 1.23E-93 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10265 177dc4a652188bcefba9f8b4bf276859 287 Gene3D G3DSA:3.40.50.720 1 192 3.7E-29 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10265 177dc4a652188bcefba9f8b4bf276859 287 PANTHER PTHR10491:SF4 1 287 9.3E-95 T 21-04-2016 SPH21_RS10265 177dc4a652188bcefba9f8b4bf276859 287 PANTHER PTHR10491 1 287 9.3E-95 T 21-04-2016 IPR005913 dTDP-4-dehydrorhamnose reductase family SPH21_RS10265 177dc4a652188bcefba9f8b4bf276859 287 TIGRFAM TIGR01214 rmlD: dTDP-4-dehydrorhamnose reductase 3 281 4.2E-97 T 21-04-2016 IPR005913 dTDP-4-dehydrorhamnose reductase family SPH21_RS10265 177dc4a652188bcefba9f8b4bf276859 287 Pfam PF04321 RmlD substrate binding domain 3 282 8.9E-103 T 21-04-2016 IPR029903 RmlD-like substrate binding domain SPH21_RS10265 177dc4a652188bcefba9f8b4bf276859 287 Gene3D G3DSA:3.90.25.10 214 265 1.1E-31 T 21-04-2016 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 SUPERFAMILY SSF143968 318 461 3.4E-23 T 21-04-2016 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 Gene3D G3DSA:3.40.1670.10 519 578 3.9E-6 T 21-04-2016 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 Gene3D G3DSA:3.40.1670.10 335 458 1.6E-16 T 21-04-2016 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 Pfam PF01977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 11 436 1.4E-111 T 21-04-2016 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978|UniPathway: UPA00232 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 SUPERFAMILY SSF143968 525 604 1.12E-7 T 21-04-2016 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 SUPERFAMILY SSF50475 3 317 1.1E-88 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 PANTHER PTHR30108 1 501 1.8E-200 T 21-04-2016 SPH21_RS10915 25b1a896e53d2a258200ccf095a01baf 612 PANTHER PTHR30108:SF7 1 501 1.8E-200 T 21-04-2016 SPH21_RS13445 fc5e35c19d0b66774bd451e4f13a7e70 329 SUPERFAMILY SSF50891 193 306 1.21E-8 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS13445 fc5e35c19d0b66774bd451e4f13a7e70 329 PANTHER PTHR18866:SF74 163 329 3.6E-24 T 21-04-2016 SPH21_RS13445 fc5e35c19d0b66774bd451e4f13a7e70 329 TIGRFAM TIGR00724 urea_amlyse_rel: biotin-dependent carboxylase uncharacterized domain 3 325 4.3E-78 T 21-04-2016 IPR003778 Carboxyltransferase domain, subdomain A and B SPH21_RS13445 fc5e35c19d0b66774bd451e4f13a7e70 329 PANTHER PTHR18866 163 329 3.6E-24 T 21-04-2016 SPH21_RS13445 fc5e35c19d0b66774bd451e4f13a7e70 329 Gene3D G3DSA:2.40.100.10 243 311 7.5E-7 T 21-04-2016 IPR029000 Cyclophilin-like domain SPH21_RS13445 fc5e35c19d0b66774bd451e4f13a7e70 329 SMART SM00797 24 317 3.7E-88 T 21-04-2016 IPR003778 Carboxyltransferase domain, subdomain A and B SPH21_RS13445 fc5e35c19d0b66774bd451e4f13a7e70 329 Pfam PF02626 Allophanate hydrolase subunit 2 26 300 1.5E-76 T 21-04-2016 IPR003778 Carboxyltransferase domain, subdomain A and B SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 SMART SM00829 8 329 2.5E-13 T 21-04-2016 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 Pfam PF00107 Zinc-binding dehydrogenase 169 293 3.0E-25 T 21-04-2016 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 SUPERFAMILY SSF50129 1 162 2.13E-40 T 21-04-2016 IPR011032 GroES-like SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 124 1.1E-14 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 SUPERFAMILY SSF51735 133 305 2.22E-40 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 Gene3D G3DSA:3.40.50.720 164 278 8.3E-23 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 Gene3D G3DSA:3.90.180.10 1 163 5.2E-40 T 21-04-2016 IPR011032 GroES-like SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 PANTHER PTHR11695:SF509 13 332 8.4E-104 T 21-04-2016 SPH21_RS05230 f8355932f9e3216ac5c97c8cdf5842a1 332 PANTHER PTHR11695 13 332 8.4E-104 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS11985 b24aba225989bf75b0c1fed794fe45b0 334 Pfam PF13505 Outer membrane protein beta-barrel domain 12 246 6.7E-12 T 21-04-2016 IPR027385 Outer membrane protein beta-barrel SPH21_RS11985 b24aba225989bf75b0c1fed794fe45b0 334 SUPERFAMILY SSF56925 211 246 4.71E-12 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS11985 b24aba225989bf75b0c1fed794fe45b0 334 SUPERFAMILY SSF56925 77 176 4.71E-12 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS11985 b24aba225989bf75b0c1fed794fe45b0 334 Gene3D G3DSA:2.40.160.20 27 178 3.0E-12 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS11985 b24aba225989bf75b0c1fed794fe45b0 334 Gene3D G3DSA:2.40.160.20 210 245 3.0E-12 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS00615 08b2f5e4c2674a60c9f95b1ee8f91fb0 216 SUPERFAMILY SSF52218 45 172 3.15E-22 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS00615 08b2f5e4c2674a60c9f95b1ee8f91fb0 216 PANTHER PTHR39201:SF1 22 216 1.8E-42 T 21-04-2016 SPH21_RS00615 08b2f5e4c2674a60c9f95b1ee8f91fb0 216 PANTHER PTHR39201 22 216 1.8E-42 T 21-04-2016 SPH21_RS00615 08b2f5e4c2674a60c9f95b1ee8f91fb0 216 Pfam PF12682 Flavodoxin 46 189 1.4E-19 T 21-04-2016 IPR008254 Flavodoxin/nitric oxide synthase GO:0010181 SPH21_RS00615 08b2f5e4c2674a60c9f95b1ee8f91fb0 216 Gene3D G3DSA:3.40.50.360 45 212 6.3E-24 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 SUPERFAMILY SSF53335 177 387 4.66E-33 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 PANTHER PTHR22807:SF33 191 354 1.4E-35 T 21-04-2016 SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 Pfam PF01189 16S rRNA methyltransferase RsmB/F 210 356 3.7E-24 T 21-04-2016 IPR001678 SAM-dependent methyltransferase RsmB/NOP2-type GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 370 387 5.2E-16 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 217 227 5.2E-16 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 188 202 5.2E-16 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 285 297 5.2E-16 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 335 351 5.2E-16 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 Gene3D G3DSA:3.40.50.150 199 387 1.3E-28 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS11035 bfaa2a3561fb17b1f7482a6f6754880a 390 PANTHER PTHR22807 191 354 1.4E-35 T 21-04-2016 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 SMART SM00870 3 325 1.2E-99 T 21-04-2016 IPR006034 Asparaginase/glutaminase GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 PIRSF PIRSF001220 1 336 3.5E-83 T 21-04-2016 IPR006034 Asparaginase/glutaminase GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 PANTHER PTHR11707:SF28 1 337 7.4E-122 T 21-04-2016 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 PIRSF PIRSF500176 1 334 1.7E-90 T 21-04-2016 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 TIGRFAM TIGR00519 asnASE_I: L-asparaginase, type I 1 337 4.3E-89 T 21-04-2016 IPR006033 L-asparaginase, type I GO:0004067|GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 SUPERFAMILY SSF53774 1 337 9.03E-99 T 21-04-2016 IPR006034 Asparaginase/glutaminase GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 Pfam PF00710 Asparaginase, N-terminal 3 193 5.8E-60 T 21-04-2016 IPR027474 L-asparaginase, N-terminal SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 PANTHER PTHR11707 1 337 7.4E-122 T 21-04-2016 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 Gene3D G3DSA:3.40.50.40 212 337 1.8E-41 T 21-04-2016 IPR027473 L-asparaginase, C-terminal domain SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 ProSitePatterns PS00144 Asparaginase / glutaminase active site signature 1. 6 14 - T 21-04-2016 IPR020827 Asparaginase/glutaminase, active site 1 GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 PRINTS PR00139 Asparaginase/glutaminase family signature 80 98 7.0E-12 T 21-04-2016 IPR006034 Asparaginase/glutaminase GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 PRINTS PR00139 Asparaginase/glutaminase family signature 262 280 7.0E-12 T 21-04-2016 IPR006034 Asparaginase/glutaminase GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 PRINTS PR00139 Asparaginase/glutaminase family signature 4 15 7.0E-12 T 21-04-2016 IPR006034 Asparaginase/glutaminase GO:0006520 SPH21_RS06120 358654e24e0ab67f0ae574e5abf9d2fc 338 Gene3D G3DSA:3.40.50.1170 1 209 8.7E-69 T 21-04-2016 IPR027474 L-asparaginase, N-terminal SPH21_RS11510 2d7b745edfae8471733f47794a0e33a2 358 Gene3D G3DSA:3.40.50.720 1 133 1.9E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11510 2d7b745edfae8471733f47794a0e33a2 358 SUPERFAMILY SSF55347 136 286 4.14E-13 T 21-04-2016 SPH21_RS11510 2d7b745edfae8471733f47794a0e33a2 358 SUPERFAMILY SSF51735 2 151 2.11E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11510 2d7b745edfae8471733f47794a0e33a2 358 PANTHER PTHR22604 1 354 5.3E-51 T 21-04-2016 SPH21_RS11510 2d7b745edfae8471733f47794a0e33a2 358 Gene3D G3DSA:3.30.360.10 134 259 4.1E-19 T 21-04-2016 SPH21_RS11510 2d7b745edfae8471733f47794a0e33a2 358 Gene3D G3DSA:3.30.360.10 291 345 4.1E-19 T 21-04-2016 SPH21_RS11510 2d7b745edfae8471733f47794a0e33a2 358 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 3 119 8.1E-19 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 343 364 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 408 423 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 430 450 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 264 278 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 5 27 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 175 200 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 307 314 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 139 148 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 37 52 3.1E-47 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 Gene3D G3DSA:3.50.50.60 145 334 3.5E-51 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 4 321 2.9E-57 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 SUPERFAMILY SSF55424 346 459 3.95E-33 T 21-04-2016 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 347 453 8.5E-28 T 21-04-2016 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 Gene3D G3DSA:3.50.50.60 3 144 5.4E-33 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 SUPERFAMILY SSF51905 3 321 1.11E-51 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 175 193 8.5E-22 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 263 279 8.5E-22 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 8.5E-22 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 292 314 8.5E-22 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PANTHER PTHR22912 1 459 2.1E-168 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PANTHER PTHR22912:SF145 1 459 2.1E-168 T 21-04-2016 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 Gene3D G3DSA:3.30.390.30 335 460 6.5E-37 T 21-04-2016 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SPH21_RS12740 862d56329ecf929b661f6496a5effbb6 461 PIRSF PIRSF000350 1 459 8.8E-107 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 67 1078 3.6E-254 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 SUPERFAMILY SSF49464 67 146 6.8E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 237 267 1.5E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 SUPERFAMILY SSF56935 144 284 5.95E-81 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 SUPERFAMILY SSF56935 479 824 5.95E-81 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 SUPERFAMILY SSF56935 901 945 5.95E-81 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 SUPERFAMILY SSF56935 990 1077 5.95E-81 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 SUPERFAMILY SSF56935 362 452 5.95E-81 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Pfam PF07715 TonB-dependent Receptor Plug Domain 156 261 2.4E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Gene3D G3DSA:2.40.170.20 1008 1078 7.9E-40 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Gene3D G3DSA:2.40.170.20 910 974 7.9E-40 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Gene3D G3DSA:2.40.170.20 479 831 7.9E-40 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Gene3D G3DSA:2.40.170.20 366 444 7.9E-40 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Pfam PF13715 CarboxypepD_reg-like domain 68 148 1.1E-12 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 PANTHER PTHR11532 484 523 8.0E-242 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 PANTHER PTHR11532 557 1076 8.0E-242 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 PANTHER PTHR11532 41 418 8.0E-242 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 PANTHER PTHR11532:SF57 484 523 8.0E-242 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 PANTHER PTHR11532:SF57 557 1076 8.0E-242 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 PANTHER PTHR11532:SF57 41 418 8.0E-242 T 21-04-2016 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Gene3D G3DSA:2.170.130.10 152 264 5.3E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00540 579a94be155c63ac993af4d2132d3b2d 1078 Gene3D G3DSA:2.60.40.1120 68 151 4.9E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12095 a40f722fc09fd4ebb7a6fdf4ef532dd2 302 PANTHER PTHR30329:SF4 99 290 1.0E-34 T 21-04-2016 SPH21_RS12095 a40f722fc09fd4ebb7a6fdf4ef532dd2 302 Gene3D G3DSA:3.30.1330.60 143 269 9.4E-33 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS12095 a40f722fc09fd4ebb7a6fdf4ef532dd2 302 SUPERFAMILY SSF103088 144 269 6.93E-31 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS12095 a40f722fc09fd4ebb7a6fdf4ef532dd2 302 Pfam PF00691 OmpA family 164 263 5.9E-21 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS12095 a40f722fc09fd4ebb7a6fdf4ef532dd2 302 PANTHER PTHR30329 99 290 1.0E-34 T 21-04-2016 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 31 186 9.5E-26 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 PANTHER PTHR30173 30 184 6.4E-41 T 21-04-2016 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 Pfam PF04542 Sigma-70 region 2 45 101 6.8E-8 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 SUPERFAMILY SSF88946 24 115 3.81E-13 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 30 185 3.1E-42 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 PANTHER PTHR30173:SF20 30 184 6.4E-41 T 21-04-2016 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 Gene3D G3DSA:1.10.10.10 128 188 1.1E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 Pfam PF08281 Sigma-70, region 4 132 184 7.4E-14 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 SUPERFAMILY SSF88659 118 191 5.23E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02400 f0a750207e2a9ce62557e540f4115a2a 218 Gene3D G3DSA:1.10.1740.10 28 127 3.1E-14 T 21-04-2016 SPH21_RS24995 379358fbfa27022abced408b4065091c 161 Gene3D G3DSA:1.25.40.20 85 155 2.3E-22 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS24995 379358fbfa27022abced408b4065091c 161 PANTHER PTHR24188 2 158 1.5E-41 T 21-04-2016 SPH21_RS24995 379358fbfa27022abced408b4065091c 161 SUPERFAMILY SSF48403 6 155 1.57E-42 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS24995 379358fbfa27022abced408b4065091c 161 PRINTS PR01415 Ankyrin repeat signature 37 52 2.2E-5 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS24995 379358fbfa27022abced408b4065091c 161 PRINTS PR01415 Ankyrin repeat signature 85 99 2.2E-5 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS24995 379358fbfa27022abced408b4065091c 161 Pfam PF12796 Ankyrin repeats (3 copies) 8 99 2.0E-13 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS24995 379358fbfa27022abced408b4065091c 161 Pfam PF13637 Ankyrin repeats (many copies) 110 152 1.8E-6 T 21-04-2016 SPH21_RS24995 379358fbfa27022abced408b4065091c 161 Gene3D G3DSA:1.25.40.20 7 84 7.7E-25 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS24995 379358fbfa27022abced408b4065091c 161 SMART SM00248 69 98 0.001 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS24995 379358fbfa27022abced408b4065091c 161 SMART SM00248 36 65 6.5E-5 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS24995 379358fbfa27022abced408b4065091c 161 SMART SM00248 102 131 0.0026 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS15740 5731afd626c1065c8078311784327d0c 340 Gene3D G3DSA:3.90.550.10 4 249 1.4E-52 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS15740 5731afd626c1065c8078311784327d0c 340 SUPERFAMILY SSF53448 2 274 5.98E-62 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS15740 5731afd626c1065c8078311784327d0c 340 PANTHER PTHR22916 161 274 1.8E-48 T 21-04-2016 SPH21_RS15740 5731afd626c1065c8078311784327d0c 340 PANTHER PTHR22916 3 140 1.8E-48 T 21-04-2016 SPH21_RS15740 5731afd626c1065c8078311784327d0c 340 Pfam PF00535 Glycosyl transferase family 2 7 144 5.6E-24 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS15740 5731afd626c1065c8078311784327d0c 340 PANTHER PTHR22916:SF26 161 274 1.8E-48 T 21-04-2016 SPH21_RS15740 5731afd626c1065c8078311784327d0c 340 PANTHER PTHR22916:SF26 3 140 1.8E-48 T 21-04-2016 SPH21_RS16255 573ce75c09cbc2968a02c1028ba901d3 544 Pfam PF12771 Starch-binding associating with outer membrane 1 541 1.9E-16 T 21-04-2016 SPH21_RS16255 573ce75c09cbc2968a02c1028ba901d3 544 PANTHER PTHR35148 1 308 1.4E-12 T 21-04-2016 SPH21_RS16255 573ce75c09cbc2968a02c1028ba901d3 544 PANTHER PTHR35148 337 542 1.4E-12 T 21-04-2016 SPH21_RS16255 573ce75c09cbc2968a02c1028ba901d3 544 SUPERFAMILY SSF48452 17 311 2.47E-83 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16255 573ce75c09cbc2968a02c1028ba901d3 544 SUPERFAMILY SSF48452 348 542 2.47E-83 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 SUPERFAMILY SSF51445 64 329 2.86E-23 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 PANTHER PTHR30032 231 421 3.0E-82 T 21-04-2016 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 PANTHER PTHR30032 30 209 3.0E-82 T 21-04-2016 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 Gene3D G3DSA:2.60.40.10 413 512 1.7E-10 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 Pfam PF02638 Glycosyl hydrolase-like 10 36 345 5.7E-76 T 21-04-2016 IPR003790 Glycosyl hydrolase-like 10 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 Gene3D G3DSA:3.20.20.80 121 190 5.5E-4 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 Gene3D G3DSA:3.20.20.80 191 309 0.001 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 SUPERFAMILY SSF49265 412 510 9.44E-11 T 21-04-2016 IPR003961 Fibronectin type III GO:0005515 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 PANTHER PTHR30032:SF2 231 421 3.0E-82 T 21-04-2016 SPH21_RS06470 5a1fe87dab4574c085d3362ec4f05a22 516 PANTHER PTHR30032:SF2 30 209 3.0E-82 T 21-04-2016 SPH21_RS13465 677b7b2ae955df9fda2c4bb00093127d 243 Pfam PF08241 Methyltransferase domain 47 141 2.7E-22 T 21-04-2016 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SPH21_RS13465 677b7b2ae955df9fda2c4bb00093127d 243 Gene3D G3DSA:3.40.50.150 3 226 1.2E-38 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS13465 677b7b2ae955df9fda2c4bb00093127d 243 PANTHER PTHR10108:SF877 192 217 2.1E-53 T 21-04-2016 SPH21_RS13465 677b7b2ae955df9fda2c4bb00093127d 243 PANTHER PTHR10108:SF877 1 172 2.1E-53 T 21-04-2016 SPH21_RS13465 677b7b2ae955df9fda2c4bb00093127d 243 SUPERFAMILY SSF53335 5 234 1.53E-45 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS13465 677b7b2ae955df9fda2c4bb00093127d 243 PANTHER PTHR10108 192 217 2.1E-53 T 21-04-2016 SPH21_RS13465 677b7b2ae955df9fda2c4bb00093127d 243 PANTHER PTHR10108 1 172 2.1E-53 T 21-04-2016 SPH21_RS12495 1a3924b41b03525beb42b06dd1c96f33 358 Pfam PF03739 Predicted permease YjgP/YjgQ family 6 355 8.2E-58 T 21-04-2016 IPR005495 Permease LptG/LptF-related GO:0016021 SPH21_RS12495 1a3924b41b03525beb42b06dd1c96f33 358 PANTHER PTHR33529 1 358 2.8E-64 T 21-04-2016 SPH21_RS12495 1a3924b41b03525beb42b06dd1c96f33 358 PANTHER PTHR33529:SF1 1 358 2.8E-64 T 21-04-2016 SPH21_RS26220 a4aa5e33c6d2518cb9bf7fd210866a83 348 SUPERFAMILY SSF101898 107 317 3.14E-12 T 21-04-2016 SPH21_RS26220 a4aa5e33c6d2518cb9bf7fd210866a83 348 Gene3D G3DSA:2.120.10.30 106 267 8.1E-8 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 Hamap MF_00197 Diaminopimelate epimerase [dapF]. 1 260 27.335 T 21-04-2016 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 Gene3D G3DSA:3.10.310.10 1 132 4.1E-39 T 21-04-2016 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 SUPERFAMILY SSF54506 1 116 8.37E-32 T 21-04-2016 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 SUPERFAMILY SSF54506 124 257 2.59E-25 T 21-04-2016 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 Gene3D G3DSA:3.10.310.10 133 235 1.4E-23 T 21-04-2016 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 Pfam PF01678 Diaminopimelate epimerase 130 239 4.3E-12 T 21-04-2016 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 Pfam PF01678 Diaminopimelate epimerase 3 117 7.9E-25 T 21-04-2016 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 PANTHER PTHR31689 1 263 4.6E-49 T 21-04-2016 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 PANTHER PTHR31689:SF0 1 263 4.6E-49 T 21-04-2016 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 ProSitePatterns PS01326 Diaminopimelate epimerase signature. 63 77 - T 21-04-2016 IPR018510 Diaminopimelate epimerase, active site GO:0005737|GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS05440 40eb32cb4c9170a73274d453ae31fe3a 263 TIGRFAM TIGR00652 DapF: diaminopimelate epimerase 2 257 7.3E-59 T 21-04-2016 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097|UniPathway: UPA00034 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 Pfam PF03466 LysR substrate binding domain 119 280 1.1E-7 T 21-04-2016 IPR005119 LysR, substrate-binding SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 SUPERFAMILY SSF53850 118 282 9.64E-11 T 21-04-2016 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 Gene3D G3DSA:3.40.190.10 119 170 7.9E-4 T 21-04-2016 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 PANTHER PTHR30126:SF11 1 280 3.5E-41 T 21-04-2016 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 3.6E-6 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 3.6E-6 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 3.6E-6 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 SUPERFAMILY SSF46785 1 81 1.28E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 Gene3D G3DSA:1.10.10.10 1 85 4.8E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 63 1.3E-17 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS20220 22c93001ff7defbb160907b676b7c55e 298 PANTHER PTHR30126 1 280 3.5E-41 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 SUPERFAMILY SSF81665 310 404 9.15E-16 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 SUPERFAMILY SSF81665 159 213 9.15E-16 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 SUPERFAMILY SSF81665 642 680 9.15E-16 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 182 680 2.1E-82 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 SUPERFAMILY SSF55008 3 70 4.97E-12 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 TIGRFAM TIGR01512 ATPase-IB2_Cd: cadmium-translocating P-type ATPase 176 695 2.2E-118 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 ProSitePatterns PS01047 Heavy-metal-associated domain. 12 40 - T 21-04-2016 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 Gene3D G3DSA:2.70.150.10 145 309 4.8E-30 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 Pfam PF00122 E1-E2 ATPase 181 401 2.0E-64 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PANTHER PTHR24093:SF50 1 697 7.3E-188 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 Gene3D G3DSA:3.40.50.1000 514 661 2.5E-48 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 Gene3D G3DSA:3.40.50.1000 381 426 2.5E-48 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 Gene3D G3DSA:3.40.1110.10 432 502 3.1E-4 T 21-04-2016 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 SUPERFAMILY SSF56784 410 428 5.77E-47 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 SUPERFAMILY SSF56784 465 692 5.77E-47 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 146 695 1.7E-166 T 21-04-2016 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PANTHER PTHR24093 1 697 7.3E-188 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 593 612 2.6E-18 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 410 424 2.6E-18 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 259 273 2.6E-18 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 616 628 2.6E-18 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 Pfam PF00702 haloacid dehalogenase-like hydrolase 407 607 1.3E-30 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 Gene3D G3DSA:3.30.70.100 5 71 1.6E-13 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 129 696 4.8E-160 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00943 Copper-transporting ATPase signature 49 69 4.4E-8 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00943 Copper-transporting ATPase signature 571 588 4.4E-8 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00943 Copper-transporting ATPase signature 627 641 4.4E-8 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00943 Copper-transporting ATPase signature 332 346 4.4E-8 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 PRINTS PR00943 Copper-transporting ATPase signature 199 217 4.4E-8 T 21-04-2016 SPH21_RS17160 197f40313453abe8f8dca3741b19479c 700 SUPERFAMILY SSF81653 215 309 1.83E-25 T 21-04-2016 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 Pfam PF13720 Udp N-acetylglucosamine O-acyltransferase; Domain 2 173 254 1.4E-24 T 21-04-2016 IPR029098 Udp N-acetylglucosamine O-acyltransferase, C-terminal KEGG: 00010+2.3.1.12|KEGG: 00020+2.3.1.12|KEGG: 00540+2.3.1.129|KEGG: 00620+2.3.1.12|UniPathway: UPA00359 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 TIGRFAM TIGR01852 lipid_A_lpxA: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase 2 254 2.8E-98 T 21-04-2016 IPR010137 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase GO:0008610|GO:0008780 KEGG: 00010+2.3.1.12|KEGG: 00020+2.3.1.12|KEGG: 00540+2.3.1.129|KEGG: 00620+2.3.1.12|UniPathway: UPA00359 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 29 64 7.6E-9 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 102 136 8.6E-8 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 1 28 8.5E-5 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 PIRSF PIRSF000456 1 261 3.3E-100 T 21-04-2016 IPR010137 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase GO:0008610|GO:0008780 KEGG: 00010+2.3.1.12|KEGG: 00020+2.3.1.12|KEGG: 00540+2.3.1.129|KEGG: 00620+2.3.1.12|UniPathway: UPA00359 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 SUPERFAMILY SSF51161 1 254 5.89E-78 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 Gene3D G3DSA:1.20.1180.10 190 255 2.9E-20 T 21-04-2016 IPR029098 Udp N-acetylglucosamine O-acyltransferase, C-terminal KEGG: 00010+2.3.1.12|KEGG: 00020+2.3.1.12|KEGG: 00540+2.3.1.129|KEGG: 00620+2.3.1.12|UniPathway: UPA00359 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 PANTHER PTHR23416:SF8 1 247 4.7E-112 T 21-04-2016 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 PANTHER PTHR23416 1 247 4.7E-112 T 21-04-2016 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 146 174 - T 21-04-2016 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: REACT_17015 SPH21_RS07630 87b02a85418b44b44b8927236e6a3195 264 Gene3D G3DSA:2.160.10.10 1 184 1.1E-54 T 21-04-2016 SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 Gene3D G3DSA:1.10.8.300 213 320 2.2E-34 T 21-04-2016 SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 Pfam PF07726 ATPase family associated with various cellular activities (AAA) 49 179 1.3E-64 T 21-04-2016 IPR011703 ATPase, AAA-3 GO:0005524|GO:0016887 SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 PIRSF PIRSF002849 1 325 1.7E-131 T 21-04-2016 IPR016366 ATPase chaperone, AAA-type, MoxR, predicted SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 SUPERFAMILY SSF52540 19 296 1.59E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 SMART SM00382 46 187 0.003 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 Gene3D G3DSA:3.40.50.300 30 195 4.1E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 PANTHER PTHR11603 11 325 8.1E-132 T 21-04-2016 SPH21_RS03515 179f001a289b8f31c6d3341b6ad93f89 325 PANTHER PTHR11603:SF149 11 325 8.1E-132 T 21-04-2016 SPH21_RS23955 304973811722439c86278def08cf6539 139 Gene3D G3DSA:3.10.129.10 7 132 1.9E-15 T 21-04-2016 IPR029069 HotDog domain SPH21_RS23955 304973811722439c86278def08cf6539 139 Pfam PF13279 Thioesterase-like superfamily 14 129 5.0E-6 T 21-04-2016 SPH21_RS23955 304973811722439c86278def08cf6539 139 SUPERFAMILY SSF54637 3 133 1.05E-18 T 21-04-2016 IPR029069 HotDog domain SPH21_RS23955 304973811722439c86278def08cf6539 139 PANTHER PTHR31793 11 133 6.5E-12 T 21-04-2016 SPH21_RS10925 938e08638b602eab9247cd022d401124 175 SUPERFAMILY SSF47240 11 168 7.03E-50 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS10925 938e08638b602eab9247cd022d401124 175 Gene3D G3DSA:1.20.1260.10 7 170 1.4E-51 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS10925 938e08638b602eab9247cd022d401124 175 PANTHER PTHR11431:SF4 13 173 4.8E-36 T 21-04-2016 SPH21_RS10925 938e08638b602eab9247cd022d401124 175 Pfam PF00210 Ferritin-like domain 18 148 1.1E-34 T 21-04-2016 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 SPH21_RS10925 938e08638b602eab9247cd022d401124 175 PANTHER PTHR11431 13 173 4.8E-36 T 21-04-2016 IPR001519 Ferritin GO:0006826|GO:0006879|GO:0008199 SPH21_RS12800 6ab135e5866e9679cedcaa994f9e00c0 310 Gene3D G3DSA:3.30.530.20 3 154 2.0E-15 T 21-04-2016 IPR023393 START-like domain SPH21_RS12800 6ab135e5866e9679cedcaa994f9e00c0 310 Gene3D G3DSA:3.30.530.20 165 306 2.4E-28 T 21-04-2016 IPR023393 START-like domain SPH21_RS12800 6ab135e5866e9679cedcaa994f9e00c0 310 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 180 297 8.1E-12 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS12800 6ab135e5866e9679cedcaa994f9e00c0 310 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 16 138 1.7E-7 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS12800 6ab135e5866e9679cedcaa994f9e00c0 310 SUPERFAMILY SSF55961 169 300 7.21E-23 T 21-04-2016 SPH21_RS12800 6ab135e5866e9679cedcaa994f9e00c0 310 SUPERFAMILY SSF55961 4 139 6.38E-16 T 21-04-2016 SPH21_RS05670 e372c1a949c818082a333c70f918e4b3 104 Pfam PF00581 Rhodanese-like domain 5 94 7.6E-14 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS05670 e372c1a949c818082a333c70f918e4b3 104 Gene3D G3DSA:3.40.250.10 1 98 1.7E-27 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS05670 e372c1a949c818082a333c70f918e4b3 104 SMART SM00450 5 99 3.4E-20 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS05670 e372c1a949c818082a333c70f918e4b3 104 SUPERFAMILY SSF52821 2 99 4.98E-29 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS05670 e372c1a949c818082a333c70f918e4b3 104 PANTHER PTHR12231 1 95 5.8E-16 T 21-04-2016 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 PANTHER PTHR11113:SF3 8 399 2.9E-163 T 21-04-2016 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 Gene3D G3DSA:2.30.40.10 342 396 5.3E-12 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 TIGRFAM TIGR00221 nagA: N-acetylglucosamine-6-phosphate deacetylase 7 389 5.3E-90 T 21-04-2016 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 PANTHER PTHR11113 8 399 2.9E-163 T 21-04-2016 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 Gene3D G3DSA:2.30.40.10 7 62 3.1E-13 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 SUPERFAMILY SSF51338 363 396 4.77E-20 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 SUPERFAMILY SSF51338 7 57 4.77E-20 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 SUPERFAMILY SSF51556 58 363 1.08E-81 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 Pfam PF01979 Amidohydrolase family 55 391 3.6E-28 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 PIRSF PIRSF038994 4 396 2.4E-120 T 21-04-2016 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395 SPH21_RS14150 95fafe3349e83334e13dd3bb07b8fedd 401 Gene3D G3DSA:3.20.20.140 63 341 6.7E-85 T 21-04-2016 SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 SUPERFAMILY SSF55874 286 439 3.93E-35 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 338 438 2.5E-17 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 Gene3D G3DSA:3.30.450.20 108 147 1.1E-4 T 21-04-2016 SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 Gene3D G3DSA:3.30.565.10 296 439 9.6E-37 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 PANTHER PTHR24423 108 439 7.0E-60 T 21-04-2016 SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 PANTHER PTHR24423:SF450 108 439 7.0E-60 T 21-04-2016 SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 SMART SM00387 335 439 2.0E-20 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 PRINTS PR00344 Bacterial sensor protein C-terminal signature 427 439 3.2E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 PRINTS PR00344 Bacterial sensor protein C-terminal signature 392 402 3.2E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 PRINTS PR00344 Bacterial sensor protein C-terminal signature 374 388 3.2E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05755 92353d30072b2bb7db73b25ce81002a0 439 PRINTS PR00344 Bacterial sensor protein C-terminal signature 403 421 3.2E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 Gene3D G3DSA:3.40.50.300 428 495 9.3E-7 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 Pfam PF02463 RecF/RecN/SMC N terminal domain 1 508 4.2E-20 T 21-04-2016 IPR003395 RecF/RecN/SMC, N-terminal SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 TIGRFAM TIGR00634 recN: DNA repair protein RecN 1 549 6.7E-145 T 21-04-2016 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 PANTHER PTHR11059 2 549 6.4E-136 T 21-04-2016 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 Gene3D G3DSA:3.40.50.300 1 202 1.1E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 SUPERFAMILY SSF52540 287 499 7.31E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 SUPERFAMILY SSF52540 2 50 7.31E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 SUPERFAMILY SSF52540 1 216 6.76E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01950 414c9e190d1e8e84ee2c317a5db7827e 551 PIRSF PIRSF003128 1 551 9.9E-163 T 21-04-2016 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 SPH21_RS04505 24941d6b6c98080726846224187adade 129 PANTHER PTHR36437:SF1 1 125 1.5E-44 T 21-04-2016 SPH21_RS04505 24941d6b6c98080726846224187adade 129 Gene3D G3DSA:3.10.180.10 2 127 6.2E-21 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS04505 24941d6b6c98080726846224187adade 129 PANTHER PTHR36437 1 125 1.5E-44 T 21-04-2016 SPH21_RS04505 24941d6b6c98080726846224187adade 129 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 7 125 3.3E-12 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS04505 24941d6b6c98080726846224187adade 129 SUPERFAMILY SSF54593 3 128 6.46E-23 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS25600 6de2f4a9263493ba74e85dc15d4f9a7a 178 SMART SM00935 10 170 2.1E-48 T 21-04-2016 IPR005632 Chaperone protein Skp GO:0051082 SPH21_RS25600 6de2f4a9263493ba74e85dc15d4f9a7a 178 Pfam PF03938 Outer membrane protein (OmpH-like) 8 169 2.6E-36 T 21-04-2016 IPR005632 Chaperone protein Skp GO:0051082 SPH21_RS25600 6de2f4a9263493ba74e85dc15d4f9a7a 178 Gene3D G3DSA:3.30.910.20 11 58 2.1E-24 T 21-04-2016 SPH21_RS25600 6de2f4a9263493ba74e85dc15d4f9a7a 178 Gene3D G3DSA:3.30.910.20 99 169 2.1E-24 T 21-04-2016 SPH21_RS25600 6de2f4a9263493ba74e85dc15d4f9a7a 178 PANTHER PTHR35089 4 176 9.3E-40 T 21-04-2016 SPH21_RS25600 6de2f4a9263493ba74e85dc15d4f9a7a 178 SUPERFAMILY SSF111384 21 169 3.4E-28 T 21-04-2016 IPR024930 Skp domain SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 Gene3D G3DSA:1.10.10.10 117 177 4.2E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 PANTHER PTHR30173 18 180 3.0E-39 T 21-04-2016 SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 SUPERFAMILY SSF88946 16 100 1.18E-25 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 Pfam PF04542 Sigma-70 region 2 23 89 3.7E-18 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 18 175 8.5E-31 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 Pfam PF08281 Sigma-70, region 4 121 173 5.9E-16 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 Gene3D G3DSA:1.10.1740.10 6 101 1.7E-31 T 21-04-2016 SPH21_RS19450 6671702a9acaff2bc68a81f499c0173f 181 SUPERFAMILY SSF88659 123 178 2.43E-14 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Gene3D G3DSA:2.60.40.320 170 292 3.7E-28 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 SUPERFAMILY SSF49785 5 179 8.63E-48 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Gene3D G3DSA:2.60.40.1560 614 697 1.7E-24 T 21-04-2016 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Gene3D G3DSA:2.60.120.260 25 169 4.0E-47 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Pfam PF00703 Glycosyl hydrolases family 2 193 291 7.2E-15 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Pfam PF16355 Domain of unknown function (DUF4982) 625 684 1.3E-21 T 21-04-2016 IPR032311 Domain of unknown function DUF4982 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 SUPERFAMILY SSF49303 187 291 7.19E-15 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 28 178 1.5E-31 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 SUPERFAMILY SSF51445 289 608 9.94E-76 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 ProSitePatterns PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 404 418 - T 21-04-2016 IPR023232 Glycoside hydrolase, family 2, active site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 300 452 7.7E-30 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Gene3D G3DSA:3.20.20.80 544 612 2.0E-82 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Gene3D G3DSA:3.20.20.80 296 512 2.0E-82 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 Gene3D G3DSA:2.60.40.920 698 791 1.9E-4 T 21-04-2016 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PRINTS PR00132 Glycosyl hydrolase family 2 signature 303 317 1.8E-12 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PRINTS PR00132 Glycosyl hydrolase family 2 signature 334 352 1.8E-12 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PRINTS PR00132 Glycosyl hydrolase family 2 signature 109 124 1.8E-12 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PRINTS PR00132 Glycosyl hydrolase family 2 signature 404 419 1.8E-12 T 21-04-2016 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PANTHER PTHR10066 540 739 5.4E-210 T 21-04-2016 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PANTHER PTHR10066 26 501 5.4E-210 T 21-04-2016 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PANTHER PTHR10066:SF71 540 739 5.4E-210 T 21-04-2016 SPH21_RS11475 11fe9d9abbc2bf8bed013fc2739fd4b3 803 PANTHER PTHR10066:SF71 26 501 5.4E-210 T 21-04-2016 SPH21_RS03225 a0fcebcb76a5955d94111d031b04fa29 380 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 107 309 1.8E-21 T 21-04-2016 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 SPH21_RS03225 a0fcebcb76a5955d94111d031b04fa29 380 SUPERFAMILY SSF53383 24 368 1.33E-68 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS03225 a0fcebcb76a5955d94111d031b04fa29 380 Gene3D G3DSA:3.40.640.10 63 279 7.5E-41 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS03225 a0fcebcb76a5955d94111d031b04fa29 380 PANTHER PTHR11999:SF110 11 369 5.5E-106 T 21-04-2016 SPH21_RS03225 a0fcebcb76a5955d94111d031b04fa29 380 PANTHER PTHR11999 11 369 5.5E-106 T 21-04-2016 SPH21_RS03225 a0fcebcb76a5955d94111d031b04fa29 380 ProSitePatterns PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. 224 245 - T 21-04-2016 IPR021115 Pyridoxal-phosphate binding site GO:0016831 SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 SUPERFAMILY SSF88946 16 100 3.3E-13 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 Pfam PF08281 Sigma-70, region 4 120 169 2.7E-9 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 21 174 3.1E-17 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 SUPERFAMILY SSF88659 106 177 7.63E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 Pfam PF04542 Sigma-70 region 2 23 86 3.0E-6 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 Gene3D G3DSA:1.10.10.10 113 176 3.7E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 PANTHER PTHR30173 22 193 5.3E-25 T 21-04-2016 SPH21_RS12350 3fa2520886a56d96eb84e032b2b33bfd 194 Gene3D G3DSA:1.10.1740.10 15 88 1.2E-13 T 21-04-2016 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 SUPERFAMILY SSF52172 3 127 1.71E-35 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 SMART SM00448 4 115 2.7E-34 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 Pfam PF00486 Transcriptional regulatory protein, C terminal 154 226 1.1E-16 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 SMART SM00862 152 226 2.4E-13 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 Gene3D G3DSA:1.10.10.10 131 226 4.2E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 Gene3D G3DSA:3.40.50.2300 3 129 1.0E-35 T 21-04-2016 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 PANTHER PTHR26402:SF606 4 227 3.8E-67 T 21-04-2016 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 SUPERFAMILY SSF46894 132 228 9.35E-20 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 Pfam PF00072 Response regulator receiver domain 6 116 1.2E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS20195 abfc3d04db726ae0801abc2839df0c35 230 PANTHER PTHR26402 4 227 3.8E-67 T 21-04-2016 SPH21_RS10330 b44cbf859a97816e9427f952bb80d7a8 200 PANTHER PTHR24422 100 200 7.7E-16 T 21-04-2016 SPH21_RS10330 b44cbf859a97816e9427f952bb80d7a8 200 PANTHER PTHR24422:SF6 100 200 7.7E-16 T 21-04-2016 SPH21_RS10330 b44cbf859a97816e9427f952bb80d7a8 200 SUPERFAMILY SSF52738 8 192 5.89E-41 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS10330 b44cbf859a97816e9427f952bb80d7a8 200 Pfam PF01339 CheB methylesterase 11 185 3.1E-40 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS10330 b44cbf859a97816e9427f952bb80d7a8 200 Gene3D G3DSA:3.40.50.180 6 192 7.2E-46 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS10270 9dd7066b96a28588cb4a866c34038983 176 PANTHER PTHR11839:SF9 1 160 1.0E-36 T 21-04-2016 SPH21_RS10270 9dd7066b96a28588cb4a866c34038983 176 ProSitePatterns PS00893 Nudix box signature. 75 96 - T 21-04-2016 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SPH21_RS10270 9dd7066b96a28588cb4a866c34038983 176 SUPERFAMILY SSF55811 2 174 1.62E-41 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS10270 9dd7066b96a28588cb4a866c34038983 176 PANTHER PTHR11839 1 160 1.0E-36 T 21-04-2016 SPH21_RS10270 9dd7066b96a28588cb4a866c34038983 176 Gene3D G3DSA:3.90.79.10 2 173 4.1E-48 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS10270 9dd7066b96a28588cb4a866c34038983 176 Pfam PF00293 NUDIX domain 44 154 1.2E-15 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 SUPERFAMILY SSF103473 9 438 1.57E-66 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 ProSitePatterns PS00216 Sugar transport proteins signature 1. 297 314 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 PANTHER PTHR23500:SF22 9 438 2.0E-159 T 21-04-2016 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 2 436 1.7E-105 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 ProSitePatterns PS00217 Sugar transport proteins signature 2. 109 134 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 PRINTS PR00171 Sugar transporter signature 362 374 9.9E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 PRINTS PR00171 Sugar transporter signature 253 263 9.9E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 PRINTS PR00171 Sugar transporter signature 339 360 9.9E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 PRINTS PR00171 Sugar transporter signature 104 123 9.9E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 PRINTS PR00171 Sugar transporter signature 21 31 9.9E-22 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 Pfam PF00083 Sugar (and other) transporter 14 439 1.8E-106 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 PANTHER PTHR23500 9 438 2.0E-159 T 21-04-2016 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 Gene3D G3DSA:1.20.1250.20 241 435 5.4E-21 T 21-04-2016 SPH21_RS23635 2da0eb6f6fafb22e05f28a088f032d80 440 Gene3D G3DSA:1.20.1250.20 16 194 1.5E-20 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 Gene3D G3DSA:2.60.40.1120 46 128 5.6E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 Pfam PF13715 CarboxypepD_reg-like domain 46 126 1.0E-18 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 PANTHER PTHR11532:SF51 226 424 1.6E-179 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 PANTHER PTHR11532:SF51 42 210 1.6E-179 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 PANTHER PTHR11532:SF51 491 1064 1.6E-179 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 Pfam PF07715 TonB-dependent Receptor Plug Domain 136 259 1.8E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 PANTHER PTHR11532 226 424 1.6E-179 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 PANTHER PTHR11532 42 210 1.6E-179 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 PANTHER PTHR11532 491 1064 1.6E-179 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 45 1066 3.3E-184 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 Gene3D G3DSA:2.40.170.20 357 453 2.4E-37 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 Gene3D G3DSA:2.40.170.20 485 864 2.4E-37 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 SUPERFAMILY SSF49464 46 124 4.97E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 235 265 2.1E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 SUPERFAMILY SSF56935 122 282 1.5E-80 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 SUPERFAMILY SSF56935 874 924 1.5E-80 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 SUPERFAMILY SSF56935 347 437 1.5E-80 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 SUPERFAMILY SSF56935 478 823 1.5E-80 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 SUPERFAMILY SSF56935 972 1063 1.5E-80 T 21-04-2016 SPH21_RS13105 14a41c7d1030b3154bf4dfe433c1d800 1066 Gene3D G3DSA:2.170.130.10 129 262 3.2E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24770 f811b8a77fe64e49ed3aabd3c7122930 150 Gene3D G3DSA:3.10.180.10 2 148 5.9E-52 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS24770 f811b8a77fe64e49ed3aabd3c7122930 150 SUPERFAMILY SSF54593 5 145 2.06E-33 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS24770 f811b8a77fe64e49ed3aabd3c7122930 150 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 9 141 1.0E-8 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS05700 a4773e7a96e5453ac54b85bfe4cc5e32 124 TIGRFAM TIGR00082 rbfA: ribosome-binding factor A 4 118 3.4E-19 T 21-04-2016 IPR000238 Ribosome-binding factor A GO:0006364 SPH21_RS05700 a4773e7a96e5453ac54b85bfe4cc5e32 124 PANTHER PTHR33515 5 124 2.2E-27 T 21-04-2016 SPH21_RS05700 a4773e7a96e5453ac54b85bfe4cc5e32 124 Gene3D G3DSA:3.30.300.20 5 119 9.5E-27 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS05700 a4773e7a96e5453ac54b85bfe4cc5e32 124 Hamap MF_00003 Ribosome-binding factor A [rbfA]. 4 120 17.11 T 21-04-2016 IPR000238 Ribosome-binding factor A GO:0006364 SPH21_RS05700 a4773e7a96e5453ac54b85bfe4cc5e32 124 ProDom PD007327 FACTOR A RIBOSOME-BINDING PROCESSING RRNA 3D-STRUCTURE RIBOSOMAL-BINDING PRECURSOR A RBFA 15 100 6.0E-6 T 21-04-2016 IPR000238 Ribosome-binding factor A GO:0006364 SPH21_RS05700 a4773e7a96e5453ac54b85bfe4cc5e32 124 SUPERFAMILY SSF89919 4 116 1.13E-26 T 21-04-2016 IPR023799 Ribosome-binding factor A domain SPH21_RS05700 a4773e7a96e5453ac54b85bfe4cc5e32 124 Pfam PF02033 Ribosome-binding factor A 8 113 1.4E-24 T 21-04-2016 IPR000238 Ribosome-binding factor A GO:0006364 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 Gene3D G3DSA:3.40.430.10 3 164 2.5E-65 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 SUPERFAMILY SSF53597 4 163 1.82E-58 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 Pfam PF00186 Dihydrofolate reductase 4 161 6.6E-65 T 21-04-2016 IPR001796 Dihydrofolate reductase domain GO:0004146|GO:0006545|GO:0009165|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|UniPathway: UPA00077 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 PANTHER PTHR22778:SF16 1 162 3.7E-49 T 21-04-2016 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 PIRSF PIRSF000194 1 165 6.2E-60 T 21-04-2016 IPR012259 Dihydrofolate reductase GO:0004146|GO:0006545|GO:0009165|GO:0050661|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|UniPathway: UPA00077 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 PANTHER PTHR22778 1 162 3.7E-49 T 21-04-2016 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 PRINTS PR00070 Dihydrofolate reductase signature 14 24 1.24E-15 T 21-04-2016 IPR012259 Dihydrofolate reductase GO:0004146|GO:0006545|GO:0009165|GO:0050661|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|UniPathway: UPA00077 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 PRINTS PR00070 Dihydrofolate reductase signature 41 52 1.24E-15 T 21-04-2016 IPR012259 Dihydrofolate reductase GO:0004146|GO:0006545|GO:0009165|GO:0050661|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|UniPathway: UPA00077 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 PRINTS PR00070 Dihydrofolate reductase signature 93 107 1.24E-15 T 21-04-2016 IPR012259 Dihydrofolate reductase GO:0004146|GO:0006545|GO:0009165|GO:0050661|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|UniPathway: UPA00077 SPH21_RS14795 3998d2a98a984ea6fa9ca13a2030c2cb 165 PRINTS PR00070 Dihydrofolate reductase signature 28 36 1.24E-15 T 21-04-2016 IPR012259 Dihydrofolate reductase GO:0004146|GO:0006545|GO:0009165|GO:0050661|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|UniPathway: UPA00077 SPH21_RS03120 c363fea2f3f5ed02e238562c838644c6 460 Pfam PF16490 Putative oxidoreductase C terminal domain 180 458 1.2E-137 T 21-04-2016 IPR032459 Putative oxidoreductase, C-terminal SPH21_RS03120 c363fea2f3f5ed02e238562c838644c6 460 PANTHER PTHR22604:SF14 101 250 4.1E-24 T 21-04-2016 SPH21_RS03120 c363fea2f3f5ed02e238562c838644c6 460 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 75 161 1.5E-6 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS03120 c363fea2f3f5ed02e238562c838644c6 460 SUPERFAMILY SSF51735 98 183 9.67E-9 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03120 c363fea2f3f5ed02e238562c838644c6 460 PANTHER PTHR22604 101 250 4.1E-24 T 21-04-2016 SPH21_RS03120 c363fea2f3f5ed02e238562c838644c6 460 Gene3D G3DSA:3.40.50.720 93 250 2.8E-12 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 Pfam PF00753 Metallo-beta-lactamase superfamily 34 102 8.3E-9 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 TIGRFAM TIGR02651 RNase_Z: ribonuclease Z 4 303 5.6E-89 T 21-04-2016 IPR013471 Ribonuclease Z/BN GO:0016891|GO:0042779 SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 Gene3D G3DSA:3.60.15.10 196 303 1.5E-67 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 Gene3D G3DSA:3.60.15.10 4 158 1.5E-67 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 Hamap MF_01818 Ribonuclease BN [rbn]. 3 303 31.107 T 21-04-2016 IPR013471 Ribonuclease Z/BN GO:0016891|GO:0042779 SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 SUPERFAMILY SSF56281 4 303 1.22E-66 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 PANTHER PTHR12553 182 303 3.3E-66 T 21-04-2016 SPH21_RS12555 8fc65344ac1eca5b8f18e24868b3184c 303 PANTHER PTHR12553 1 153 3.3E-66 T 21-04-2016 SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 Gene3D G3DSA:3.30.70.920 58 153 4.8E-27 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 Gene3D G3DSA:1.10.10.10 5 55 6.0E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 PANTHER PTHR30154:SF28 1 154 5.3E-52 T 21-04-2016 SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 SUPERFAMILY SSF54909 67 152 2.01E-18 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 21 32 2.7E-12 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 5 21 2.7E-12 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 32 51 2.7E-12 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 Pfam PF13412 Winged helix-turn-helix DNA-binding 6 52 1.5E-14 T 21-04-2016 SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 SMART SM00344 5 114 4.5E-31 T 21-04-2016 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 ProSitePatterns PS00519 AsnC-type HTH domain signature. 23 49 - T 21-04-2016 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 Pfam PF01037 Lrp/AsnC ligand binding domain 72 145 7.2E-19 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 SUPERFAMILY SSF46785 5 95 7.0E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS03230 2eb7a5d6ed7f96d1b72c3fed0b50f62f 156 PANTHER PTHR30154 1 154 5.3E-52 T 21-04-2016 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 Pfam PF13715 CarboxypepD_reg-like domain 37 122 2.1E-16 T 21-04-2016 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 Gene3D G3DSA:2.170.130.10 121 233 6.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 Gene3D G3DSA:2.40.170.20 234 767 4.8E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 PANTHER PTHR32552:SF15 58 771 1.2E-35 T 21-04-2016 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 Gene3D G3DSA:2.60.40.1120 36 120 1.7E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 Pfam PF00593 TonB dependent receptor 512 767 1.3E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 Pfam PF07715 TonB-dependent Receptor Plug Domain 133 234 1.4E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 SUPERFAMILY SSF49464 35 120 1.57E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 PANTHER PTHR32552 58 771 1.2E-35 T 21-04-2016 SPH21_RS12620 0a98d92ee60f44492ec38f00ace3bea1 777 SUPERFAMILY SSF56935 116 769 1.5E-75 T 21-04-2016 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 Pfam PF13715 CarboxypepD_reg-like domain 28 113 2.4E-16 T 21-04-2016 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 SUPERFAMILY SSF49452 21 102 1.82E-16 T 21-04-2016 IPR013784 Carbohydrate-binding-like fold GO:0030246 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 Gene3D G3DSA:2.40.170.20 253 820 9.5E-106 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 PANTHER PTHR32552:SF10 132 820 7.6E-83 T 21-04-2016 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 SUPERFAMILY SSF56935 108 820 1.01E-102 T 21-04-2016 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 Pfam PF07715 TonB-dependent Receptor Plug Domain 138 231 1.1E-10 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 ProSitePatterns PS01156 TonB-dependent receptor proteins signature 2. 803 820 - T 21-04-2016 IPR010917 TonB-dependent receptor, conserved site SPH21_RS24945 491c41311d603408d4bee406502167e1 820 PANTHER PTHR32552 132 820 7.6E-83 T 21-04-2016 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 Gene3D G3DSA:2.60.40.1120 28 119 1.8E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS24945 491c41311d603408d4bee406502167e1 820 TIGRFAM TIGR01783 TonB-siderophor: TonB-dependent siderophore receptor 141 820 4.6E-67 T 21-04-2016 IPR010105 TonB-dependent siderophore receptor GO:0004872|GO:0005506|GO:0015891 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 Pfam PF00593 TonB dependent receptor 580 818 3.8E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24945 491c41311d603408d4bee406502167e1 820 Gene3D G3DSA:2.170.130.10 123 245 1.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS07615 faa2bf674bccbe484db19628a0023bf5 408 Gene3D G3DSA:1.10.3210.10 3 246 1.5E-79 T 21-04-2016 IPR006674 HD domain SPH21_RS07615 faa2bf674bccbe484db19628a0023bf5 408 PANTHER PTHR11373:SF4 1 338 3.1E-75 T 21-04-2016 SPH21_RS07615 faa2bf674bccbe484db19628a0023bf5 408 Pfam PF01966 HD domain 54 125 2.9E-7 T 21-04-2016 IPR006674 HD domain SPH21_RS07615 faa2bf674bccbe484db19628a0023bf5 408 SMART SM00471 50 175 1.9E-8 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS07615 faa2bf674bccbe484db19628a0023bf5 408 PANTHER PTHR11373 1 338 3.1E-75 T 21-04-2016 SPH21_RS07615 faa2bf674bccbe484db19628a0023bf5 408 SUPERFAMILY SSF109604 2 406 3.51E-101 T 21-04-2016 SPH21_RS21080 911c2d5d30218a6109955702b73968ea 374 PANTHER PTHR24423 1 195 5.8E-63 T 21-04-2016 SPH21_RS21080 911c2d5d30218a6109955702b73968ea 374 PANTHER PTHR24423 358 373 5.8E-63 T 21-04-2016 SPH21_RS21080 911c2d5d30218a6109955702b73968ea 374 Gene3D G3DSA:3.40.50.300 18 226 3.8E-91 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21080 911c2d5d30218a6109955702b73968ea 374 PANTHER PTHR24423:SF510 1 195 5.8E-63 T 21-04-2016 SPH21_RS21080 911c2d5d30218a6109955702b73968ea 374 PANTHER PTHR24423:SF510 358 373 5.8E-63 T 21-04-2016 SPH21_RS21080 911c2d5d30218a6109955702b73968ea 374 Pfam PF02702 Osmosensitive K+ channel His kinase sensor domain 20 228 1.8E-88 T 21-04-2016 IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal GO:0000155|GO:0000160|GO:0004673|GO:0016020 SPH21_RS21350 5b76b1334526e927e9bfc92b92c919ac 120 SUPERFAMILY SSF52091 1 118 4.71E-23 T 21-04-2016 IPR002645 STAS domain SPH21_RS21350 5b76b1334526e927e9bfc92b92c919ac 120 Pfam PF11964 SpoIIAA-like 13 118 2.5E-13 T 21-04-2016 IPR021866 SpoIIAA-like SPH21_RS21350 5b76b1334526e927e9bfc92b92c919ac 120 Gene3D G3DSA:3.40.50.10600 1 119 8.4E-22 T 21-04-2016 IPR021866 SpoIIAA-like SPH21_RS23090 61855e1536d5597bdc89f6b82c77ff74 146 Gene3D G3DSA:1.20.1290.10 2 144 2.3E-48 T 21-04-2016 IPR029032 AhpD-like SPH21_RS23090 61855e1536d5597bdc89f6b82c77ff74 146 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 29 77 1.6E-18 T 21-04-2016 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS23090 61855e1536d5597bdc89f6b82c77ff74 146 Pfam PF02627 Carboxymuconolactone decarboxylase family 13 93 1.1E-16 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS23090 61855e1536d5597bdc89f6b82c77ff74 146 SUPERFAMILY SSF69118 5 144 3.72E-41 T 21-04-2016 IPR029032 AhpD-like SPH21_RS14740 93f0a40952459731e2c0b66e3aa3774d 373 Pfam PF01758 Sodium Bile acid symporter family 91 268 2.8E-35 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS14740 93f0a40952459731e2c0b66e3aa3774d 373 PANTHER PTHR10361 12 356 7.8E-71 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS25040 fa2595936d4239494f6f26856f6752e6 510 Pfam PF07980 SusD family 270 510 6.8E-37 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS25040 fa2595936d4239494f6f26856f6752e6 510 SUPERFAMILY SSF48452 27 510 4.11E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25040 fa2595936d4239494f6f26856f6752e6 510 Gene3D G3DSA:1.25.40.10 212 323 2.8E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25040 fa2595936d4239494f6f26856f6752e6 510 Gene3D G3DSA:1.25.40.10 364 453 2.8E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25040 fa2595936d4239494f6f26856f6752e6 510 Pfam PF14322 Starch-binding associating with outer membrane 103 230 1.5E-20 T 21-04-2016 SPH21_RS05705 8c29a28206179af2fc8ea13264a485f0 213 TIGRFAM TIGR00667 aat: leucyl/phenylalanyl-tRNA--protein transferase 36 212 1.1E-58 T 21-04-2016 IPR004616 Leucyl/phenylalanyl-tRNA-protein transferase GO:0008914|GO:0030163 SPH21_RS05705 8c29a28206179af2fc8ea13264a485f0 213 Hamap MF_00688 Leucyl/phenylalanyl-tRNA--protein transferase [aat]. 1 213 75.382 T 21-04-2016 IPR004616 Leucyl/phenylalanyl-tRNA-protein transferase GO:0008914|GO:0030163 SPH21_RS05705 8c29a28206179af2fc8ea13264a485f0 213 PANTHER PTHR30098 1 212 4.5E-61 T 21-04-2016 SPH21_RS05705 8c29a28206179af2fc8ea13264a485f0 213 Pfam PF03588 Leucyl/phenylalanyl-tRNA protein transferase 33 203 1.0E-66 T 21-04-2016 IPR004616 Leucyl/phenylalanyl-tRNA-protein transferase GO:0008914|GO:0030163 SPH21_RS05705 8c29a28206179af2fc8ea13264a485f0 213 SUPERFAMILY SSF55729 2 212 3.18E-78 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 Gene3D G3DSA:1.10.287.1080 136 230 1.3E-12 T 21-04-2016 SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 Gene3D G3DSA:1.10.287.1080 27 82 1.1E-8 T 21-04-2016 SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 TIGRFAM TIGR00444 mazG: MazG family protein 29 265 9.5E-84 T 21-04-2016 IPR011551 NTP pyrophosphohydrolase MazG SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 SUPERFAMILY SSF101386 15 113 2.62E-21 T 21-04-2016 SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 PANTHER PTHR30522:SF0 14 267 1.6E-105 T 21-04-2016 IPR011551 NTP pyrophosphohydrolase MazG SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 SUPERFAMILY SSF101386 140 245 1.53E-23 T 21-04-2016 SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 36 108 9.6E-24 T 21-04-2016 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 175 237 1.8E-5 T 21-04-2016 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core SPH21_RS17645 ad9c2906388bcccdcec828f88e972f70 267 PANTHER PTHR30522 14 267 1.6E-105 T 21-04-2016 SPH21_RS02155 4fda81e13c3ca0b7600e8107757d6b5c 296 SUPERFAMILY SSF51695 46 288 2.38E-43 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS02155 4fda81e13c3ca0b7600e8107757d6b5c 296 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 53 201 5.4E-20 T 21-04-2016 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SPH21_RS02155 4fda81e13c3ca0b7600e8107757d6b5c 296 PANTHER PTHR23344 43 168 2.4E-30 T 21-04-2016 IPR004129 Glycerophosphoryl diester phosphodiesterase GO:0008889 SPH21_RS02155 4fda81e13c3ca0b7600e8107757d6b5c 296 Gene3D G3DSA:3.20.20.190 37 291 1.1E-45 T 21-04-2016 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SPH21_RS23535 226b3358d4a3ae47def48e3f18198131 333 SUPERFAMILY SSF51430 15 321 4.19E-53 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS23535 226b3358d4a3ae47def48e3f18198131 333 PANTHER PTHR11732:SF241 109 333 2.6E-84 T 21-04-2016 SPH21_RS23535 226b3358d4a3ae47def48e3f18198131 333 PANTHER PTHR11732:SF241 15 92 2.6E-84 T 21-04-2016 SPH21_RS23535 226b3358d4a3ae47def48e3f18198131 333 PANTHER PTHR11732 109 333 2.6E-84 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS23535 226b3358d4a3ae47def48e3f18198131 333 PANTHER PTHR11732 15 92 2.6E-84 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS23535 226b3358d4a3ae47def48e3f18198131 333 Gene3D G3DSA:3.20.20.100 15 321 8.6E-47 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS23535 226b3358d4a3ae47def48e3f18198131 333 Pfam PF00248 Aldo/keto reductase family 15 320 4.5E-44 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS07400 74b15beba2997abe2e7d42ebbaa99905 253 PANTHER PTHR11941 1 247 6.4E-65 T 21-04-2016 SPH21_RS07400 74b15beba2997abe2e7d42ebbaa99905 253 Gene3D G3DSA:3.90.226.10 1 223 2.7E-45 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS07400 74b15beba2997abe2e7d42ebbaa99905 253 Pfam PF00378 Enoyl-CoA hydratase/isomerase 8 216 1.5E-44 T 21-04-2016 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SPH21_RS07400 74b15beba2997abe2e7d42ebbaa99905 253 PANTHER PTHR11941:SF45 1 247 6.4E-65 T 21-04-2016 SPH21_RS07400 74b15beba2997abe2e7d42ebbaa99905 253 SUPERFAMILY SSF52096 1 228 5.32E-52 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS00850 a095bdc6b876d09494025d01fd1f7da7 97 Pfam PF03118 Bacterial RNA polymerase, alpha chain C terminal domain 47 90 1.2E-5 T 21-04-2016 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS00850 a095bdc6b876d09494025d01fd1f7da7 97 SUPERFAMILY SSF47789 45 96 3.79E-10 T 21-04-2016 SPH21_RS00850 a095bdc6b876d09494025d01fd1f7da7 97 Gene3D G3DSA:1.10.150.20 47 96 2.7E-10 T 21-04-2016 SPH21_RS00850 a095bdc6b876d09494025d01fd1f7da7 97 ProDom PD001179 RNA POLYMERASE ALPHA DNA-DIRECTED SUBUNIT CHAIN NUCLEOTIDYLTRANSFERASE TRANSFERASE TRANSCRIPTION TRANSCRIPTASE 51 96 0.007 T 21-04-2016 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 SUPERFAMILY SSF75005 28 186 8.28E-11 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 Gene3D G3DSA:2.60.120.260 279 433 2.6E-6 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 PANTHER PTHR31776 242 866 2.7E-207 T 21-04-2016 SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 PANTHER PTHR31776:SF0 242 866 2.7E-207 T 21-04-2016 SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 SUPERFAMILY SSF49785 279 434 1.85E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 SUPERFAMILY SSF51445 423 764 2.87E-60 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 Pfam PF06964 Alpha-L-arabinofuranosidase C-terminal domain 682 843 4.8E-30 T 21-04-2016 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55|UniPathway: UPA00667 SPH21_RS21210 6bb73da290038ec844604e299e081f59 868 SMART SM00813 682 858 1.2E-33 T 21-04-2016 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55|UniPathway: UPA00667 SPH21_RS07905 e0fcda5a73d1136873edfe5b74848d8e 109 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 16 104 1.9E-24 T 21-04-2016 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SPH21_RS07905 e0fcda5a73d1136873edfe5b74848d8e 109 Hamap MF_01456 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic [ndhE]. 11 109 21.129 T 21-04-2016 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SPH21_RS07905 e0fcda5a73d1136873edfe5b74848d8e 109 PANTHER PTHR11434 12 109 3.8E-39 T 21-04-2016 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SPH21_RS10680 98327f28c8517b96e0897a5c43079b7b 235 Gene3D G3DSA:3.30.240.20 102 171 6.7E-13 T 21-04-2016 IPR023090 Uncharacterised domain UPF0702, alpha/beta domain SPH21_RS10680 98327f28c8517b96e0897a5c43079b7b 235 Pfam PF04239 Protein of unknown function (DUF421) 111 171 5.5E-9 T 21-04-2016 IPR007353 Protein of unknown function DUF421 SPH21_RS10680 98327f28c8517b96e0897a5c43079b7b 235 PANTHER PTHR34582 9 197 9.5E-28 T 21-04-2016 SPH21_RS05950 b89d21491d954522869743fa413abe8b 825 Pfam PF02687 FtsX-like permease family 316 431 6.2E-13 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05950 b89d21491d954522869743fa413abe8b 825 Pfam PF02687 FtsX-like permease family 707 818 1.7E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05950 b89d21491d954522869743fa413abe8b 825 PANTHER PTHR30572 427 825 1.4E-61 T 21-04-2016 SPH21_RS05950 b89d21491d954522869743fa413abe8b 825 PANTHER PTHR30572 313 380 1.4E-61 T 21-04-2016 SPH21_RS05950 b89d21491d954522869743fa413abe8b 825 PANTHER PTHR30572:SF4 427 825 1.4E-61 T 21-04-2016 SPH21_RS05950 b89d21491d954522869743fa413abe8b 825 PANTHER PTHR30572:SF4 313 380 1.4E-61 T 21-04-2016 SPH21_RS05950 b89d21491d954522869743fa413abe8b 825 Pfam PF12704 MacB-like periplasmic core domain 38 256 1.8E-17 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 Gene3D G3DSA:1.10.10.10 25 84 3.4E-8 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 PANTHER PTHR18964 67 401 6.6E-69 T 21-04-2016 SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 Gene3D G3DSA:3.30.420.40 228 382 7.4E-47 T 21-04-2016 SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 ProSitePatterns PS01125 ROK family signature. 222 249 - T 21-04-2016 IPR000600 ROK family SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 PANTHER PTHR18964:SF123 67 401 6.6E-69 T 21-04-2016 SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 Pfam PF00480 ROK family 92 399 9.0E-55 T 21-04-2016 IPR000600 ROK family SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 Gene3D G3DSA:3.30.420.40 87 227 7.5E-28 T 21-04-2016 SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 Pfam PF13412 Winged helix-turn-helix DNA-binding 20 65 4.4E-5 T 21-04-2016 SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 SUPERFAMILY SSF46785 26 80 6.45E-7 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 SUPERFAMILY SSF53067 88 210 8.94E-17 T 21-04-2016 SPH21_RS00560 9eb799c3de5d375bc9c63c7b0479e7d1 403 SUPERFAMILY SSF53067 215 401 3.66E-50 T 21-04-2016 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 SUPERFAMILY SSF51735 3 186 5.24E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PANTHER PTHR11728:SF1 1 332 8.9E-87 T 21-04-2016 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 Hamap MF_00394 Glycerol-3-phosphate dehydrogenase [NAD(P)+] [gpsA]. 5 328 25.965 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 Pfam PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 186 323 5.8E-48 T 21-04-2016 IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal GO:0004367|GO:0005975|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PIRSF PIRSF000114 1 333 3.2E-94 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PANTHER PTHR11728 1 332 8.9E-87 T 21-04-2016 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 62 89 2.01E-27 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 9 26 2.01E-27 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 179 203 2.01E-27 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 204 228 2.01E-27 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 244 261 2.01E-27 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 139 159 2.01E-27 T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 Gene3D G3DSA:3.40.50.720 1 189 1.5E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 SUPERFAMILY SSF48179 185 330 1.33E-43 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 ProSitePatterns PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 194 215 - T 21-04-2016 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 Pfam PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 6 165 2.0E-30 T 21-04-2016 IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal GO:0016616|GO:0046168|GO:0051287|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00940 SPH21_RS19265 86ee3fe7b8d7bc52276c08b4e853c6f8 334 Gene3D G3DSA:1.10.1040.10 190 330 3.4E-46 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 PANTHER PTHR11649 15 461 2.4E-139 T 21-04-2016 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 227 352 1.7E-21 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Gene3D G3DSA:3.30.1360.120 4 129 7.5E-43 T 21-04-2016 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Pfam PF10396 GTP-binding protein TrmE N-terminus 13 129 1.8E-36 T 21-04-2016 IPR018948 GTP-binding protein TrmE, N-terminal SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 SUPERFAMILY SSF116878 386 461 1.7E-48 T 21-04-2016 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 SUPERFAMILY SSF116878 131 230 1.7E-48 T 21-04-2016 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Pfam PF01926 50S ribosome-binding GTPase 229 343 3.2E-25 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Gene3D G3DSA:3.40.50.300 296 392 1.0E-11 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 SUPERFAMILY SSF52540 207 378 1.33E-40 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 SUPERFAMILY SSF52540 82 173 1.33E-40 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Hamap MF_00379 tRNA modification GTPase MnmE [mnmE]. 12 461 32.977 T 21-04-2016 IPR004520 tRNA modification GTPase MnmE GO:0003924|GO:0005525|GO:0005622|GO:0006400 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 TIGRFAM TIGR00450 mnmE_trmE_thdF: tRNA modification GTPase TrmE 18 461 7.7E-124 T 21-04-2016 IPR004520 tRNA modification GTPase MnmE GO:0003924|GO:0005525|GO:0005622|GO:0006400 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Gene3D G3DSA:1.20.120.430 258 281 3.4E-56 T 21-04-2016 IPR027368 tRNA modification GTPase MnmE domain 2 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Gene3D G3DSA:1.20.120.430 131 192 3.4E-56 T 21-04-2016 IPR027368 tRNA modification GTPase MnmE domain 2 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Gene3D G3DSA:1.20.120.430 393 461 3.4E-56 T 21-04-2016 IPR027368 tRNA modification GTPase MnmE domain 2 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Gene3D G3DSA:3.40.50.300 224 257 5.1E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 PANTHER PTHR11649:SF56 15 461 2.4E-139 T 21-04-2016 SPH21_RS20520 9f0b9590af4fdd8fe1a890900dcf0e60 461 Pfam PF12631 MnmE helical domain 133 458 2.3E-54 T 21-04-2016 IPR025867 MnmE, helical domain SPH21_RS08075 4b366d7dd50ea7bb0ff7ca7f3ec1777d 159 PANTHER PTHR32125 1 159 7.3E-43 T 21-04-2016 SPH21_RS08075 4b366d7dd50ea7bb0ff7ca7f3ec1777d 159 Hamap MF_00107 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [ispF]. 3 158 32.605 T 21-04-2016 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS08075 4b366d7dd50ea7bb0ff7ca7f3ec1777d 159 TIGRFAM TIGR00151 ispF: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4 158 1.3E-58 T 21-04-2016 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS08075 4b366d7dd50ea7bb0ff7ca7f3ec1777d 159 Pfam PF02542 YgbB family 4 157 6.1E-60 T 21-04-2016 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS08075 4b366d7dd50ea7bb0ff7ca7f3ec1777d 159 ProSitePatterns PS01350 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. 37 52 - T 21-04-2016 IPR020555 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site GO:0008685 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS08075 4b366d7dd50ea7bb0ff7ca7f3ec1777d 159 SUPERFAMILY SSF69765 1 158 6.41E-62 T 21-04-2016 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS08075 4b366d7dd50ea7bb0ff7ca7f3ec1777d 159 Gene3D G3DSA:3.30.1330.50 1 158 1.8E-64 T 21-04-2016 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS22855 46f8204e84128dfb9f9ad50f01d1202f 454 SUPERFAMILY SSF56954 2 83 2.49E-58 T 21-04-2016 SPH21_RS22855 46f8204e84128dfb9f9ad50f01d1202f 454 SUPERFAMILY SSF56954 108 448 2.49E-58 T 21-04-2016 SPH21_RS22855 46f8204e84128dfb9f9ad50f01d1202f 454 PANTHER PTHR30026:SF4 1 447 1.9E-34 T 21-04-2016 SPH21_RS22855 46f8204e84128dfb9f9ad50f01d1202f 454 Pfam PF02321 Outer membrane efflux protein 273 445 1.5E-20 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS22855 46f8204e84128dfb9f9ad50f01d1202f 454 Pfam PF02321 Outer membrane efflux protein 26 242 1.7E-18 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS22855 46f8204e84128dfb9f9ad50f01d1202f 454 PANTHER PTHR30026 1 447 1.9E-34 T 21-04-2016 SPH21_RS22855 46f8204e84128dfb9f9ad50f01d1202f 454 Gene3D G3DSA:1.20.1600.10 15 446 8.3E-53 T 21-04-2016 SPH21_RS17870 657d9f686c17f5e48155017903f3063f 204 SUPERFAMILY SSF53335 4 183 2.39E-24 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17870 657d9f686c17f5e48155017903f3063f 204 Gene3D G3DSA:3.40.50.150 2 203 7.9E-24 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17870 657d9f686c17f5e48155017903f3063f 204 PANTHER PTHR10108:SF838 6 174 4.7E-31 T 21-04-2016 SPH21_RS17870 657d9f686c17f5e48155017903f3063f 204 Pfam PF08241 Methyltransferase domain 43 133 1.9E-10 T 21-04-2016 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SPH21_RS17870 657d9f686c17f5e48155017903f3063f 204 PANTHER PTHR10108 6 174 4.7E-31 T 21-04-2016 SPH21_RS14355 05b0e54b9c4096910be8ff8c6f7c8d87 554 Pfam PF14322 Starch-binding associating with outer membrane 27 220 8.4E-21 T 21-04-2016 SPH21_RS14355 05b0e54b9c4096910be8ff8c6f7c8d87 554 Gene3D G3DSA:1.25.40.10 199 275 5.5E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14355 05b0e54b9c4096910be8ff8c6f7c8d87 554 Gene3D G3DSA:1.25.40.10 314 328 5.5E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14355 05b0e54b9c4096910be8ff8c6f7c8d87 554 Gene3D G3DSA:1.25.40.10 402 494 5.5E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14355 05b0e54b9c4096910be8ff8c6f7c8d87 554 SUPERFAMILY SSF48452 22 553 1.04E-111 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14355 05b0e54b9c4096910be8ff8c6f7c8d87 554 Pfam PF07980 SusD family 260 553 7.6E-50 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 PANTHER PTHR13734:SF5 8 458 4.2E-107 T 21-04-2016 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 SUPERFAMILY SSF81301 14 146 4.5E-34 T 21-04-2016 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 SUPERFAMILY SSF81891 149 457 2.35E-62 T 21-04-2016 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 TIGRFAM TIGR00277 HDIG: HDIG domain 258 316 3.5E-8 T 21-04-2016 IPR006675 HDIG domain SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 Pfam PF01743 Poly A polymerase head domain 24 151 1.8E-25 T 21-04-2016 IPR002646 Poly A polymerase, head domain GO:0003723|GO:0006396|GO:0016779 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 SMART SM00471 250 374 0.0014 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 PANTHER PTHR13734 8 458 4.2E-107 T 21-04-2016 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 Pfam PF01966 HD domain 255 352 1.1E-14 T 21-04-2016 IPR006674 HD domain SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 Gene3D G3DSA:1.10.3090.10 396 426 1.4E-58 T 21-04-2016 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 Gene3D G3DSA:1.10.3090.10 149 327 1.4E-58 T 21-04-2016 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 Gene3D G3DSA:3.30.460.10 15 146 6.7E-38 T 21-04-2016 SPH21_RS12000 7ff91f8c07a245856e3fa887978d7fba 469 Pfam PF12627 Probable RNA and SrmB- binding site of polymerase A 179 238 6.8E-19 T 21-04-2016 IPR032828 tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain SPH21_RS02595 1c2bd57d8580b820ea61b1b6df2c3b0b 185 SUPERFAMILY SSF54637 4 155 1.32E-41 T 21-04-2016 IPR029069 HotDog domain SPH21_RS02595 1c2bd57d8580b820ea61b1b6df2c3b0b 185 PANTHER PTHR11049 6 162 8.9E-53 T 21-04-2016 SPH21_RS02595 1c2bd57d8580b820ea61b1b6df2c3b0b 185 Gene3D G3DSA:3.10.129.10 5 157 3.1E-49 T 21-04-2016 IPR029069 HotDog domain SPH21_RS02595 1c2bd57d8580b820ea61b1b6df2c3b0b 185 Pfam PF03061 Thioesterase superfamily 27 98 1.9E-16 T 21-04-2016 IPR006683 Thioesterase domain SPH21_RS24980 dfc3d8a61598acd2aad0630af65a6e54 100 PANTHER PTHR38011 5 99 5.2E-20 T 21-04-2016 SPH21_RS24980 dfc3d8a61598acd2aad0630af65a6e54 100 Gene3D G3DSA:3.40.430.10 4 95 4.5E-15 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS24980 dfc3d8a61598acd2aad0630af65a6e54 100 PANTHER PTHR38011:SF2 5 99 5.2E-20 T 21-04-2016 SPH21_RS24980 dfc3d8a61598acd2aad0630af65a6e54 100 Pfam PF01872 RibD C-terminal domain 17 88 3.6E-16 T 21-04-2016 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SPH21_RS24980 dfc3d8a61598acd2aad0630af65a6e54 100 SUPERFAMILY SSF53597 3 94 3.14E-14 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS16115 de47229a9e13e53e7b84fb979305f478 711 Pfam PF06202 Amylo-alpha-1,6-glucosidase 267 635 4.0E-15 T 21-04-2016 IPR032790 Glycogen debranching enzyme, C-terminal KEGG: 00500+2.4.1.25+3.2.1.33|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SPH21_RS16115 de47229a9e13e53e7b84fb979305f478 711 PANTHER PTHR10569:SF1 335 654 3.4E-144 T 21-04-2016 SPH21_RS16115 de47229a9e13e53e7b84fb979305f478 711 PANTHER PTHR10569:SF1 240 315 3.4E-144 T 21-04-2016 SPH21_RS16115 de47229a9e13e53e7b84fb979305f478 711 PANTHER PTHR10569 335 654 3.4E-144 T 21-04-2016 IPR010401 Glycogen debranching enzyme GO:0004134|GO:0004135|GO:0005980 KEGG: 00500+3.2.1.33+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SPH21_RS16115 de47229a9e13e53e7b84fb979305f478 711 PANTHER PTHR10569 240 315 3.4E-144 T 21-04-2016 IPR010401 Glycogen debranching enzyme GO:0004134|GO:0004135|GO:0005980 KEGG: 00500+3.2.1.33+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SPH21_RS16115 de47229a9e13e53e7b84fb979305f478 711 Pfam PF14742 N-terminal domain of (some) glycogen debranching enzymes 11 205 1.3E-47 T 21-04-2016 IPR032856 Putative glycogen debranching enzyme, N-terminal SPH21_RS16115 de47229a9e13e53e7b84fb979305f478 711 SUPERFAMILY SSF48208 229 652 5.67E-84 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 109 122 3.4E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 64 79 3.4E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 123 136 3.4E-6 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 Gene3D G3DSA:3.40.50.1820 15 250 5.9E-32 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 PANTHER PTHR10992 24 278 1.5E-24 T 21-04-2016 SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 SUPERFAMILY SSF53474 16 249 1.95E-31 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 Pfam PF12697 Alpha/beta hydrolase family 41 236 3.3E-12 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS01365 0df729f3ed1cf2141eef076784577c01 288 PANTHER PTHR10992:SF880 24 278 1.5E-24 T 21-04-2016 SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 PANTHER PTHR12121 295 310 1.5E-81 T 21-04-2016 SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 PANTHER PTHR12121 29 273 1.5E-81 T 21-04-2016 SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 Gene3D G3DSA:3.60.10.10 29 307 1.7E-29 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 30 300 2.9E-16 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 SUPERFAMILY SSF56219 294 305 9.42E-42 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 SUPERFAMILY SSF56219 25 267 9.42E-42 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 PANTHER PTHR12121:SF36 295 310 1.5E-81 T 21-04-2016 SPH21_RS22525 19f9f677f38a85a496eae0d08c721d98 310 PANTHER PTHR12121:SF36 29 273 1.5E-81 T 21-04-2016 SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 SUPERFAMILY SSF52172 1 129 2.85E-31 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 Gene3D G3DSA:3.40.50.2300 2 125 1.1E-27 T 21-04-2016 SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 Gene3D G3DSA:2.40.50.40 128 197 3.1E-15 T 21-04-2016 SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 Pfam PF00072 Response regulator receiver domain 6 116 2.9E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 SMART SM00850 136 229 3.5E-21 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 SMART SM00448 4 115 6.0E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 Pfam PF04397 LytTr DNA-binding domain 139 227 8.7E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS09560 7810fc11d93d99f92606aa88aab90586 231 PANTHER PTHR26402 4 136 9.6E-24 T 21-04-2016 SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 Pfam PF00072 Response regulator receiver domain 4 110 7.2E-13 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 PANTHER PTHR26402 1 110 6.5E-18 T 21-04-2016 SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 Gene3D G3DSA:2.40.50.40 138 207 5.1E-14 T 21-04-2016 SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 SMART SM00850 147 247 6.4E-23 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 Gene3D G3DSA:3.40.50.2300 2 112 2.6E-18 T 21-04-2016 SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 Pfam PF04397 LytTr DNA-binding domain 148 246 8.4E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 SUPERFAMILY SSF52172 4 118 4.41E-21 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS21665 40411a4cf77b86082c4072b7380bb2a7 251 SMART SM00448 1 110 1.2E-10 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 SUPERFAMILY SSF56935 866 1024 3.22E-93 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 SUPERFAMILY SSF56935 109 277 3.22E-93 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 SUPERFAMILY SSF56935 443 791 3.22E-93 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 SUPERFAMILY SSF56935 322 410 3.22E-93 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 1025 1.6E-180 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 Pfam PF07715 TonB-dependent Receptor Plug Domain 123 253 1.1E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 Gene3D G3DSA:2.40.170.20 254 277 1.0E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 Gene3D G3DSA:2.40.170.20 875 1024 1.0E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 Gene3D G3DSA:2.40.170.20 331 821 1.0E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 SUPERFAMILY SSF49464 25 111 7.32E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 Gene3D G3DSA:2.60.40.1120 26 106 8.0E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 Pfam PF13715 CarboxypepD_reg-like domain 26 113 1.6E-18 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 Gene3D G3DSA:2.170.130.10 110 253 5.9E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532 1 196 5.7E-139 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532 220 376 5.7E-139 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532 407 461 5.7E-139 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532 526 1023 5.7E-139 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532:SF57 1 196 5.7E-139 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532:SF57 220 376 5.7E-139 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532:SF57 407 461 5.7E-139 T 21-04-2016 SPH21_RS16275 13ba02855fc763ad3438da6b50e36f6d 1025 PANTHER PTHR11532:SF57 526 1023 5.7E-139 T 21-04-2016 SPH21_RS05380 9fb0f731dc318489dc30fc1f62afe343 484 SUPERFAMILY SSF48452 19 482 1.61E-72 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05380 9fb0f731dc318489dc30fc1f62afe343 484 Pfam PF14322 Starch-binding associating with outer membrane 78 233 7.5E-25 T 21-04-2016 SPH21_RS05380 9fb0f731dc318489dc30fc1f62afe343 484 Pfam PF07980 SusD family 339 480 1.5E-15 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS05380 9fb0f731dc318489dc30fc1f62afe343 484 Gene3D G3DSA:1.25.40.10 215 422 5.0E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 Gene3D G3DSA:2.60.40.1120 30 128 2.2E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 Pfam PF07715 TonB-dependent Receptor Plug Domain 129 238 2.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 Gene3D G3DSA:2.40.170.20 883 1044 3.5E-49 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 Gene3D G3DSA:2.40.170.20 322 795 3.5E-49 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 Gene3D G3DSA:2.40.170.20 241 260 3.5E-49 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 SUPERFAMILY SSF56935 952 1044 5.86E-92 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 SUPERFAMILY SSF56935 313 404 5.86E-92 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 SUPERFAMILY SSF56935 441 789 5.86E-92 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 SUPERFAMILY SSF56935 117 262 5.86E-92 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 SUPERFAMILY SSF56935 876 918 5.86E-92 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 PANTHER PTHR11532:SF57 515 1042 5.5E-229 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 PANTHER PTHR11532:SF57 10 453 5.5E-229 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 Pfam PF13715 CarboxypepD_reg-like domain 30 120 4.0E-14 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 PANTHER PTHR11532 515 1042 5.5E-229 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 PANTHER PTHR11532 10 453 5.5E-229 T 21-04-2016 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 29 1044 4.4E-244 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 Gene3D G3DSA:2.170.130.10 129 240 1.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 214 244 5.8E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS11160 56ffc7880817d164d630ff6dc7ad1da1 1044 SUPERFAMILY SSF49464 29 130 3.14E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS22130 6d22df05941902164d975fb8cebbcb6f 1018 Pfam PF04738 Lantibiotic dehydratase, C terminus 44 662 1.3E-152 T 21-04-2016 IPR006827 Lantibiotic dehydratase, C-terminal SPH21_RS22130 6d22df05941902164d975fb8cebbcb6f 1018 Pfam PF14028 Lantibiotic biosynthesis dehydratase C-term 730 994 2.7E-44 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS22130 6d22df05941902164d975fb8cebbcb6f 1018 TIGRFAM TIGR03891 thiopep_ocin: thiopeptide-type bacteriocin biosynthesis domain 730 991 7.5E-53 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS11070 c210bf962d3b2ff02c21589ee6c20101 175 TIGRFAM TIGR01090 apt: adenine phosphoribosyltransferase 6 174 3.3E-66 T 21-04-2016 IPR005764 Adenine phosphoribosyl transferase GO:0003999|GO:0005737|GO:0006168 KEGG: 00230+2.4.2.7|MetaCyc: PWY-6605|MetaCyc: PWY-6610|UniPathway: UPA00588 SPH21_RS11070 c210bf962d3b2ff02c21589ee6c20101 175 Gene3D G3DSA:3.40.50.2020 4 174 3.3E-63 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS11070 c210bf962d3b2ff02c21589ee6c20101 175 Hamap MF_00004 Adenine phosphoribosyltransferase [apt]. 6 175 35.401 T 21-04-2016 IPR005764 Adenine phosphoribosyl transferase GO:0003999|GO:0005737|GO:0006168 KEGG: 00230+2.4.2.7|MetaCyc: PWY-6605|MetaCyc: PWY-6610|UniPathway: UPA00588 SPH21_RS11070 c210bf962d3b2ff02c21589ee6c20101 175 SUPERFAMILY SSF53271 7 174 5.96E-49 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS11070 c210bf962d3b2ff02c21589ee6c20101 175 Pfam PF00156 Phosphoribosyl transferase domain 45 140 5.6E-13 T 21-04-2016 IPR000836 Phosphoribosyltransferase domain GO:0009116 SPH21_RS11070 c210bf962d3b2ff02c21589ee6c20101 175 PANTHER PTHR32315 2 175 1.0E-79 T 21-04-2016 SPH21_RS14610 0400877fa46d98e57dca837f1b73010f 657 Pfam PF03772 Competence protein 198 464 6.7E-57 T 21-04-2016 IPR004477 ComEC/Rec2-related protein SPH21_RS14610 0400877fa46d98e57dca837f1b73010f 657 TIGRFAM TIGR00360 ComEC_N-term: ComEC/Rec2-related protein 219 396 6.2E-27 T 21-04-2016 IPR004477 ComEC/Rec2-related protein SPH21_RS14610 0400877fa46d98e57dca837f1b73010f 657 PANTHER PTHR30619 17 542 2.1E-60 T 21-04-2016 SPH21_RS14610 0400877fa46d98e57dca837f1b73010f 657 Pfam PF13567 Domain of unknown function (DUF4131) 2 152 9.5E-20 T 21-04-2016 IPR025405 Domain of unknown function DUF4131 SPH21_RS14610 0400877fa46d98e57dca837f1b73010f 657 PANTHER PTHR30619:SF2 17 542 2.1E-60 T 21-04-2016 SPH21_RS23905 796fa4ef7648a505c0022ce980db8774 290 Pfam PF12833 Helix-turn-helix domain 202 280 3.9E-13 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23905 796fa4ef7648a505c0022ce980db8774 290 Gene3D G3DSA:1.10.10.60 236 282 5.3E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23905 796fa4ef7648a505c0022ce980db8774 290 SUPERFAMILY SSF46689 235 283 4.12E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23905 796fa4ef7648a505c0022ce980db8774 290 SMART SM00342 196 279 3.3E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23905 796fa4ef7648a505c0022ce980db8774 290 PANTHER PTHR11019:SF45 27 287 9.5E-36 T 21-04-2016 SPH21_RS23905 796fa4ef7648a505c0022ce980db8774 290 PANTHER PTHR11019 27 287 9.5E-36 T 21-04-2016 SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 305 383 1.5E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 SUPERFAMILY SSF47384 171 254 2.35E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 SMART SM00387 297 399 0.0014 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 PANTHER PTHR24423 167 375 2.3E-27 T 21-04-2016 SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 PANTHER PTHR24423 4 9 2.3E-27 T 21-04-2016 SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 SMART SM00388 188 253 8.9E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 Pfam PF00512 His Kinase A (phospho-acceptor) domain 191 252 9.5E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 Gene3D G3DSA:1.10.287.130 186 249 1.5E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 SUPERFAMILY SSF55874 260 385 3.54E-16 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20130 5b94fd83e4b6b4721f04c3a639d98e83 422 Gene3D G3DSA:3.30.565.10 260 397 1.9E-14 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS25065 6983bbec98051e1a6ce3a054c5b3c068 152 Gene3D G3DSA:3.10.129.10 6 148 5.8E-28 T 21-04-2016 IPR029069 HotDog domain SPH21_RS25065 6983bbec98051e1a6ce3a054c5b3c068 152 PANTHER PTHR13078 14 130 5.7E-24 T 21-04-2016 SPH21_RS25065 6983bbec98051e1a6ce3a054c5b3c068 152 Pfam PF01575 MaoC like domain 11 126 4.9E-22 T 21-04-2016 IPR002539 MaoC-like domain SPH21_RS25065 6983bbec98051e1a6ce3a054c5b3c068 152 SUPERFAMILY SSF54637 7 130 1.74E-27 T 21-04-2016 IPR029069 HotDog domain SPH21_RS13160 9a6c5a5664cf2ea0aae2bf7fe1d1740a 278 PANTHER PTHR10907 41 200 1.6E-31 T 21-04-2016 SPH21_RS13160 9a6c5a5664cf2ea0aae2bf7fe1d1740a 278 Pfam PF00756 Putative esterase 51 269 4.2E-25 T 21-04-2016 IPR000801 Putative esterase SPH21_RS13160 9a6c5a5664cf2ea0aae2bf7fe1d1740a 278 PANTHER PTHR10907:SF33 41 200 1.6E-31 T 21-04-2016 SPH21_RS13160 9a6c5a5664cf2ea0aae2bf7fe1d1740a 278 Gene3D G3DSA:3.40.50.1820 4 278 6.8E-86 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13160 9a6c5a5664cf2ea0aae2bf7fe1d1740a 278 SUPERFAMILY SSF53474 36 274 1.18E-45 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 SUPERFAMILY SSF56935 854 898 3.66E-98 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 SUPERFAMILY SSF56935 935 1021 3.66E-98 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 SUPERFAMILY SSF56935 456 793 3.66E-98 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 SUPERFAMILY SSF56935 329 417 3.66E-98 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 SUPERFAMILY SSF56935 134 282 3.66E-98 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Pfam PF07715 TonB-dependent Receptor Plug Domain 145 254 1.3E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Gene3D G3DSA:2.170.130.10 142 255 7.3E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 PANTHER PTHR11532 10 38 2.5E-255 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 PANTHER PTHR11532 55 383 2.5E-255 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 PANTHER PTHR11532 472 1019 2.5E-255 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Pfam PF00593 TonB dependent receptor 628 1018 6.7E-27 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 230 260 7.6E-20 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 PANTHER PTHR11532:SF57 10 38 2.5E-255 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 PANTHER PTHR11532:SF57 55 383 2.5E-255 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 PANTHER PTHR11532:SF57 472 1019 2.5E-255 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Pfam PF13715 CarboxypepD_reg-like domain 57 138 4.5E-14 T 21-04-2016 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 SUPERFAMILY SSF49464 56 149 2.88E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Gene3D G3DSA:2.40.170.20 256 273 4.0E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Gene3D G3DSA:2.40.170.20 863 888 4.0E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Gene3D G3DSA:2.40.170.20 926 1021 4.0E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Gene3D G3DSA:2.40.170.20 338 813 4.0E-62 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 56 1021 4.8E-268 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS19275 9b14cd0fad400a63f7e8175f33b16fa1 1021 Gene3D G3DSA:2.60.40.1120 56 141 1.5E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 154 182 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 SUPERFAMILY SSF51735 10 269 3.92E-68 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PANTHER PTHR24322:SF625 16 151 6.0E-37 T 21-04-2016 SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PANTHER PTHR24322:SF625 167 203 6.0E-37 T 21-04-2016 SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PANTHER PTHR24322 16 151 6.0E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PANTHER PTHR24322 167 203 6.0E-37 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 Gene3D G3DSA:3.40.50.720 4 268 1.1E-67 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 231 251 1.9E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 1.9E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 191 208 1.9E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 167 186 1.9E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 1.9E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 141 157 1.9E-33 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 167 186 7.0E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 7.0E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 147 155 7.0E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02870 8b79a51a99df67c076d86e0504659fd6 273 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 268 2.3E-46 T 21-04-2016 SPH21_RS19540 e80de4f1f24319fbeeb5646e594ffa3e 391 Pfam PF00534 Glycosyl transferases group 1 208 352 1.1E-27 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS19540 e80de4f1f24319fbeeb5646e594ffa3e 391 PANTHER PTHR12526:SF363 76 386 4.9E-65 T 21-04-2016 SPH21_RS19540 e80de4f1f24319fbeeb5646e594ffa3e 391 Gene3D G3DSA:3.40.50.2000 173 348 3.7E-26 T 21-04-2016 SPH21_RS19540 e80de4f1f24319fbeeb5646e594ffa3e 391 Pfam PF13439 Glycosyltransferase Family 4 19 189 1.6E-19 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS19540 e80de4f1f24319fbeeb5646e594ffa3e 391 PANTHER PTHR12526 76 386 4.9E-65 T 21-04-2016 SPH21_RS19540 e80de4f1f24319fbeeb5646e594ffa3e 391 SUPERFAMILY SSF53756 14 379 4.71E-70 T 21-04-2016 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 SUPERFAMILY SSF56655 2 260 2.09E-73 T 21-04-2016 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 63 79 6.0E-48 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 179 200 6.0E-48 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 132 155 6.0E-48 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 41 61 6.0E-48 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 210 234 6.0E-48 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 83 99 6.0E-48 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PANTHER PTHR20854:SF4 1 260 5.1E-85 T 21-04-2016 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 ProSitePatterns PS00630 Inositol monophosphatase family signature 2. 213 227 - T 21-04-2016 IPR020550 Inositol monophosphatase, conserved site GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 Pfam PF00459 Inositol monophosphatase family 4 254 4.2E-56 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 Gene3D G3DSA:3.30.540.10 3 152 1.7E-44 T 21-04-2016 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PANTHER PTHR20854 1 260 5.1E-85 T 21-04-2016 IPR000760 Inositol monophosphatase GO:0046854 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR01959 SuhB family inositol monophosphatase signature 20 42 2.6E-14 T 21-04-2016 IPR022337 Inositol monophosphatase, SuhB GO:0008934|GO:0046855 KEGG: 00521+3.1.3.25|KEGG: 00562+3.1.3.25|KEGG: 04070+3.1.3.25|MetaCyc: PWY-2301|MetaCyc: PWY-4702|MetaCyc: PWY-6363 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR01959 SuhB family inositol monophosphatase signature 106 125 2.6E-14 T 21-04-2016 IPR022337 Inositol monophosphatase, SuhB GO:0008934|GO:0046855 KEGG: 00521+3.1.3.25|KEGG: 00562+3.1.3.25|KEGG: 04070+3.1.3.25|MetaCyc: PWY-2301|MetaCyc: PWY-4702|MetaCyc: PWY-6363 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR01959 SuhB family inositol monophosphatase signature 158 184 2.6E-14 T 21-04-2016 IPR022337 Inositol monophosphatase, SuhB GO:0008934|GO:0046855 KEGG: 00521+3.1.3.25|KEGG: 00562+3.1.3.25|KEGG: 04070+3.1.3.25|MetaCyc: PWY-2301|MetaCyc: PWY-4702|MetaCyc: PWY-6363 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 PRINTS PR01959 SuhB family inositol monophosphatase signature 200 212 2.6E-14 T 21-04-2016 IPR022337 Inositol monophosphatase, SuhB GO:0008934|GO:0046855 KEGG: 00521+3.1.3.25|KEGG: 00562+3.1.3.25|KEGG: 04070+3.1.3.25|MetaCyc: PWY-2301|MetaCyc: PWY-4702|MetaCyc: PWY-6363 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 Gene3D G3DSA:3.40.190.80 153 260 4.6E-34 T 21-04-2016 SPH21_RS18035 1b704f87c9dff8d5996b848f688647c2 264 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 83 96 - T 21-04-2016 IPR020583 Inositol monophosphatase, metal-binding site SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 SUPERFAMILY SSF82714 719 806 1.83E-5 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PANTHER PTHR32063 1 1035 2.8E-229 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 SUPERFAMILY SSF82693 136 181 6.8E-14 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 SUPERFAMILY SSF82693 267 323 6.8E-14 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 SUPERFAMILY SSF82714 183 265 3.14E-12 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 Gene3D G3DSA:1.10.3850.10 275 491 4.6E-50 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 Gene3D G3DSA:1.10.3850.10 814 1030 7.3E-45 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 SUPERFAMILY SSF82866 291 489 1.11E-37 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 Pfam PF00873 AcrB/AcrD/AcrF family 3 1026 2.4E-185 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 SUPERFAMILY SSF82866 806 1031 3.92E-39 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PRINTS PR00702 Acriflavin resistance protein family signature 437 460 7.0E-30 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PRINTS PR00702 Acriflavin resistance protein family signature 356 377 7.0E-30 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PRINTS PR00702 Acriflavin resistance protein family signature 10 34 7.0E-30 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PRINTS PR00702 Acriflavin resistance protein family signature 384 408 7.0E-30 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PRINTS PR00702 Acriflavin resistance protein family signature 38 56 7.0E-30 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PRINTS PR00702 Acriflavin resistance protein family signature 329 352 7.0E-30 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PRINTS PR00702 Acriflavin resistance protein family signature 462 485 7.0E-30 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 SUPERFAMILY SSF82693 40 134 3.66E-14 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 Gene3D G3DSA:3.30.2090.10 719 810 6.9E-8 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 Gene3D G3DSA:3.30.2090.10 183 264 1.2E-11 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 Gene3D G3DSA:3.30.70.1430 41 137 5.0E-12 T 21-04-2016 SPH21_RS17925 fb39c5fcc1cdad52c3a19e05e5769e2c 1058 PANTHER PTHR32063:SF0 1 1035 2.8E-229 T 21-04-2016 SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 Gene3D G3DSA:3.30.70.920 58 153 2.1E-24 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 SUPERFAMILY SSF46785 5 64 2.66E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 SUPERFAMILY SSF54909 68 149 1.74E-17 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 Pfam PF13412 Winged helix-turn-helix DNA-binding 6 50 2.3E-16 T 21-04-2016 SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 PANTHER PTHR30154 1 160 5.4E-44 T 21-04-2016 SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 Gene3D G3DSA:1.10.10.10 2 57 1.8E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 Pfam PF01037 Lrp/AsnC ligand binding domain 75 144 1.7E-16 T 21-04-2016 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 SMART SM00344 6 113 7.7E-34 T 21-04-2016 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 33 52 1.1E-15 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 6 22 1.1E-15 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS02605 1bbd3f55910dea893b028d2cc3a01af0 162 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 22 33 1.1E-15 T 21-04-2016 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 20 176 3.1E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 PANTHER PTHR30173:SF20 7 188 1.8E-31 T 21-04-2016 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 Gene3D G3DSA:1.10.1740.10 7 93 2.3E-16 T 21-04-2016 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 Pfam PF04542 Sigma-70 region 2 24 88 1.7E-8 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 PANTHER PTHR30173 7 188 1.8E-31 T 21-04-2016 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 Pfam PF08281 Sigma-70, region 4 123 173 5.9E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 SUPERFAMILY SSF88659 93 183 3.71E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 Gene3D G3DSA:1.10.10.10 115 179 1.1E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS03960 a3b42086bd159c749b1b70271cbf3ccb 188 SUPERFAMILY SSF88946 7 96 2.39E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS15260 aabf1ea1f6545925e3cd2de9eaa05933 250 SUPERFAMILY SSF52266 42 248 1.21E-37 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS15260 aabf1ea1f6545925e3cd2de9eaa05933 250 PANTHER PTHR30383 43 248 2.5E-19 T 21-04-2016 SPH21_RS15260 aabf1ea1f6545925e3cd2de9eaa05933 250 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 47 238 3.2E-21 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS15260 aabf1ea1f6545925e3cd2de9eaa05933 250 Gene3D G3DSA:3.40.50.1110 42 248 1.1E-37 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS09685 6f7657a1a50a02bfbd0f6a12c197d8f4 252 Gene3D G3DSA:2.60.120.200 34 248 1.4E-20 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS09685 6f7657a1a50a02bfbd0f6a12c197d8f4 252 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 97 243 6.5E-17 T 21-04-2016 SPH21_RS09685 6f7657a1a50a02bfbd0f6a12c197d8f4 252 SUPERFAMILY SSF49899 100 248 8.91E-22 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 Pfam PF01545 Cation efflux family 1 184 1.4E-36 T 21-04-2016 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 SUPERFAMILY SSF161111 1 186 4.32E-46 T 21-04-2016 SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 SUPERFAMILY SSF160240 190 267 1.7E-14 T 21-04-2016 SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 Gene3D G3DSA:1.20.1510.10 1 184 1.2E-36 T 21-04-2016 IPR027469 Cation efflux protein transmembrane domain SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 Pfam PF16916 Dimerisation domain of Zinc Transporter 190 267 3.2E-10 T 21-04-2016 IPR027470 Cation efflux protein, cytoplasmic domain SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 Gene3D G3DSA:3.30.70.1350 187 267 3.9E-14 T 21-04-2016 IPR027470 Cation efflux protein, cytoplasmic domain SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 1 267 1.1E-54 T 21-04-2016 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 PANTHER PTHR11562:SF55 1 267 3.1E-55 T 21-04-2016 SPH21_RS19785 c3b0fc9a828ecc25d69ab7f844611f9f 307 PANTHER PTHR11562 1 267 3.1E-55 T 21-04-2016 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SPH21_RS01845 d538b2cef33f7237f840424d431ef030 519 Pfam PF12741 Susd and RagB outer membrane lipoprotein 3 518 8.7E-105 T 21-04-2016 IPR024302 SusD-like SPH21_RS01845 d538b2cef33f7237f840424d431ef030 519 SUPERFAMILY SSF48452 20 518 1.64E-127 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS01845 d538b2cef33f7237f840424d431ef030 519 PANTHER PTHR35148 1 519 1.6E-73 T 21-04-2016 SPH21_RS17775 152e32bb470f9b3a2f581f6aa7b16e89 331 TIGRFAM TIGR03782 Bac_Flav_CT_J: Bacteroides conjugative transposon TraJ protein 2 324 1.6E-176 T 21-04-2016 IPR022393 Conjugative transposon, TraJ SPH21_RS17775 152e32bb470f9b3a2f581f6aa7b16e89 331 Pfam PF07863 Homologues of TraJ from Bacteroides conjugative transposon 271 326 6.8E-17 T 21-04-2016 IPR012424 Conjugative transposon, TraJ, C-terminal SPH21_RS15785 28694edeb9f11a7101bf822d3649c102 291 SUPERFAMILY SSF53067 131 289 1.14E-33 T 21-04-2016 SPH21_RS15785 28694edeb9f11a7101bf822d3649c102 291 PANTHER PTHR30005 1 288 5.6E-54 T 21-04-2016 SPH21_RS15785 28694edeb9f11a7101bf822d3649c102 291 Gene3D G3DSA:3.30.420.150 131 289 1.8E-28 T 21-04-2016 SPH21_RS15785 28694edeb9f11a7101bf822d3649c102 291 Gene3D G3DSA:3.30.420.40 1 121 4.2E-33 T 21-04-2016 SPH21_RS15785 28694edeb9f11a7101bf822d3649c102 291 SUPERFAMILY SSF53067 2 120 7.07E-29 T 21-04-2016 SPH21_RS15785 28694edeb9f11a7101bf822d3649c102 291 Pfam PF02541 Ppx/GppA phosphatase family 37 288 3.5E-35 T 21-04-2016 IPR003695 Ppx/GppA phosphatase KEGG: 00230+3.6.1.40|UniPathway: UPA00908 SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 PANTHER PTHR11727 4 257 7.1E-68 T 21-04-2016 IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 SUPERFAMILY SSF53335 4 257 5.84E-65 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 PANTHER PTHR11727:SF7 4 257 7.1E-68 T 21-04-2016 SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 Gene3D G3DSA:1.10.8.100 196 257 5.1E-18 T 21-04-2016 IPR023165 rRNA adenine dimethylase-like SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 TIGRFAM TIGR00755 ksgA: ribosomal RNA small subunit methyltransferase A 4 254 5.6E-71 T 21-04-2016 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 Gene3D G3DSA:3.40.50.150 4 190 2.8E-58 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 Hamap MF_00607 Ribosomal RNA small subunit methyltransferase A [rsmA]. 4 256 46.323 T 21-04-2016 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 Pfam PF00398 Ribosomal RNA adenine dimethylase 5 256 1.0E-42 T 21-04-2016 IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm SPH21_RS00035 287c12eb84a920b0ccdfd9e931ac232a 260 SMART SM00650 20 191 3.5E-42 T 21-04-2016 IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal GO:0000154|GO:0000179|GO:0008649 SPH21_RS20575 bce09d765bbc0480b5032d2306578e25 481 Gene3D G3DSA:3.30.1330.120 285 424 8.6E-61 T 21-04-2016 SPH21_RS20575 bce09d765bbc0480b5032d2306578e25 481 TIGRFAM TIGR02330 prpD: 2-methylcitrate dehydratase 11 479 7.4E-248 T 21-04-2016 IPR012705 2-methylcitrate dehydratase PrpD GO:0019629|GO:0047547|GO:0051537 KEGG: 00640+4.2.1.79|UniPathway: UPA00946 SPH21_RS20575 bce09d765bbc0480b5032d2306578e25 481 PANTHER PTHR16943 4 479 1.4E-264 T 21-04-2016 IPR005656 MmgE/PrpD GO:0016829 SPH21_RS20575 bce09d765bbc0480b5032d2306578e25 481 Pfam PF03972 MmgE/PrpD family 16 465 2.8E-158 T 21-04-2016 IPR005656 MmgE/PrpD GO:0016829 SPH21_RS20575 bce09d765bbc0480b5032d2306578e25 481 PANTHER PTHR16943:SF19 4 479 1.4E-264 T 21-04-2016 SPH21_RS20575 bce09d765bbc0480b5032d2306578e25 481 SUPERFAMILY SSF103378 10 479 9.02E-160 T 21-04-2016 IPR005656 MmgE/PrpD GO:0016829 SPH21_RS26060 9b5a827f4736ffc79ee0239f29452403 142 Pfam PF07332 Putative Actinobacterial Holin-X, holin superfamily III 27 132 2.9E-8 T 21-04-2016 IPR009937 Putative Actinobacterial Holin-X, holin superfamily III SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 SUPERFAMILY SSF88946 4 80 9.81E-12 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 SUPERFAMILY SSF88659 104 169 1.07E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 PANTHER PTHR30173:SF20 4 170 1.7E-31 T 21-04-2016 SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 Pfam PF08281 Sigma-70, region 4 114 165 5.7E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 Gene3D G3DSA:1.10.10.10 108 170 1.9E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 Gene3D G3DSA:1.10.1740.10 4 84 3.9E-11 T 21-04-2016 SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 9 168 3.4E-41 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 9 168 1.7E-22 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 Pfam PF04542 Sigma-70 region 2 13 76 2.9E-5 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24085 a23da5c63a74b5b0d597b16326d68c01 173 PANTHER PTHR30173 4 170 1.7E-31 T 21-04-2016 SPH21_RS26175 6aeea9794c9f221f5cb9cb5c69d41962 361 Pfam PF00534 Glycosyl transferases group 1 183 339 5.7E-21 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS26175 6aeea9794c9f221f5cb9cb5c69d41962 361 PANTHER PTHR12526 73 359 2.1E-26 T 21-04-2016 SPH21_RS26175 6aeea9794c9f221f5cb9cb5c69d41962 361 Gene3D G3DSA:3.40.50.2000 185 334 2.6E-14 T 21-04-2016 SPH21_RS26175 6aeea9794c9f221f5cb9cb5c69d41962 361 Pfam PF13439 Glycosyltransferase Family 4 56 172 3.8E-9 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS26175 6aeea9794c9f221f5cb9cb5c69d41962 361 SUPERFAMILY SSF53756 22 357 6.73E-53 T 21-04-2016 SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 TIGRFAM TIGR00281 TIGR00281: segregation and condensation protein B 3 175 2.1E-37 T 21-04-2016 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 PANTHER PTHR34298 8 186 4.3E-47 T 21-04-2016 SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 PANTHER PTHR34298:SF2 8 186 4.3E-47 T 21-04-2016 SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 Pfam PF04079 Segregation and condensation complex subunit ScpB 7 171 1.5E-51 T 21-04-2016 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 Gene3D G3DSA:1.10.10.10 88 162 6.0E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 SUPERFAMILY SSF46785 89 162 3.08E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 Gene3D G3DSA:1.10.10.10 2 83 6.3E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 PIRSF PIRSF019345 1 185 1.5E-50 T 21-04-2016 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 SPH21_RS15185 6a302d9549df26f39abffe3e4665aac8 186 SUPERFAMILY SSF46785 2 83 1.01E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17130 dd4fff7481eefe29ccffacb254f91895 354 PANTHER PTHR32241 4 314 5.5E-65 T 21-04-2016 SPH21_RS17130 dd4fff7481eefe29ccffacb254f91895 354 Gene3D G3DSA:3.40.1090.10 2 338 8.7E-95 T 21-04-2016 SPH21_RS17130 dd4fff7481eefe29ccffacb254f91895 354 Pfam PF01734 Patatin-like phospholipase 5 205 5.8E-19 T 21-04-2016 IPR002641 Patatin/Phospholipase A2-related GO:0006629 SPH21_RS17130 dd4fff7481eefe29ccffacb254f91895 354 PANTHER PTHR32241:SF3 4 314 5.5E-65 T 21-04-2016 SPH21_RS17130 dd4fff7481eefe29ccffacb254f91895 354 SUPERFAMILY SSF52151 2 328 2.28E-55 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 PANTHER PTHR32063:SF19 6 633 2.8E-270 T 21-04-2016 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 SUPERFAMILY SSF82866 18 90 3.53E-11 T 21-04-2016 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 PANTHER PTHR32063 6 633 2.8E-270 T 21-04-2016 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 Gene3D G3DSA:3.30.2090.10 308 392 3.5E-22 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 PRINTS PR00702 Acriflavin resistance protein family signature 137 154 2.4E-5 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 PRINTS PR00702 Acriflavin resistance protein family signature 63 86 2.4E-5 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 PRINTS PR00702 Acriflavin resistance protein family signature 38 61 2.4E-5 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 SUPERFAMILY SSF82714 308 393 5.23E-19 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 Gene3D G3DSA:1.10.3850.10 19 92 1.8E-16 T 21-04-2016 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 Gene3D G3DSA:1.10.3850.10 402 625 4.5E-42 T 21-04-2016 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 Pfam PF00873 AcrB/AcrD/AcrF family 18 625 2.0E-125 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01405 b48ad9ca6d46aa5c7bb21045c5c0377e 644 SUPERFAMILY SSF82866 390 628 1.57E-39 T 21-04-2016 SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 SMART SM00382 26 215 1.4E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 SMART SM00382 282 477 4.4E-8 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 Gene3D G3DSA:3.40.50.300 252 491 3.1E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 Gene3D G3DSA:3.40.50.300 1 225 3.2E-63 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 PANTHER PTHR24220:SF416 3 383 5.5E-159 T 21-04-2016 SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 Pfam PF00005 ABC transporter 17 167 1.3E-30 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 Pfam PF00005 ABC transporter 274 428 2.1E-23 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 ProSitePatterns PS00211 ABC transporters family signature. 401 415 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 SUPERFAMILY SSF52540 249 487 1.46E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 PANTHER PTHR24220 3 383 5.5E-159 T 21-04-2016 SPH21_RS12995 eaacdd9632326cf8dd6e7efc2107bd02 501 SUPERFAMILY SSF52540 2 227 4.26E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05195 1cfdae630b751eeef9019b5f5c7bbcc1 124 Hamap MF_01477 Ribosomal silencing factor RsfS [rsfS]. 7 114 22.327 T 21-04-2016 IPR004394 Protein Iojap/ribosomal silencing factor RsfS SPH21_RS05195 1cfdae630b751eeef9019b5f5c7bbcc1 124 TIGRFAM TIGR00090 rsfS_iojap_ybeB: ribosome silencing factor 15 113 1.1E-31 T 21-04-2016 IPR004394 Protein Iojap/ribosomal silencing factor RsfS SPH21_RS05195 1cfdae630b751eeef9019b5f5c7bbcc1 124 PANTHER PTHR21043 8 116 7.1E-27 T 21-04-2016 IPR004394 Protein Iojap/ribosomal silencing factor RsfS SPH21_RS05195 1cfdae630b751eeef9019b5f5c7bbcc1 124 Gene3D G3DSA:3.30.460.10 10 116 2.1E-31 T 21-04-2016 SPH21_RS05195 1cfdae630b751eeef9019b5f5c7bbcc1 124 Pfam PF02410 Ribosomal silencing factor during starvation 17 113 1.2E-24 T 21-04-2016 SPH21_RS05195 1cfdae630b751eeef9019b5f5c7bbcc1 124 SUPERFAMILY SSF81301 11 119 1.24E-32 T 21-04-2016 SPH21_RS11515 5ea95ca49eba189d87b5f0af4e99a7b6 525 PANTHER PTHR11819:SF7 9 484 3.4E-130 T 21-04-2016 SPH21_RS11515 5ea95ca49eba189d87b5f0af4e99a7b6 525 Pfam PF00474 Sodium:solute symporter family 43 426 7.2E-50 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS11515 5ea95ca49eba189d87b5f0af4e99a7b6 525 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 42 428 9.5E-67 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS11515 5ea95ca49eba189d87b5f0af4e99a7b6 525 PANTHER PTHR11819 9 484 3.4E-130 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS22950 a6ccfd885148a04e96cb762a380cf30b 154 SUPERFAMILY SSF55961 3 149 5.5E-21 T 21-04-2016 SPH21_RS22950 a6ccfd885148a04e96cb762a380cf30b 154 Gene3D G3DSA:3.30.530.20 2 150 2.0E-7 T 21-04-2016 IPR023393 START-like domain SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 SUPERFAMILY SSF51161 287 422 2.62E-19 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 PANTHER PTHR22572 6 422 1.3E-133 T 21-04-2016 SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 PANTHER PTHR22572:SF110 6 422 1.3E-133 T 21-04-2016 SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 TIGRFAM TIGR02091 glgC: glucose-1-phosphate adenylyltransferase 5 388 9.2E-130 T 21-04-2016 IPR011831 Glucose-1-phosphate adenylyltransferase GO:0005978|GO:0008878 KEGG: 00500+2.7.7.27|KEGG: 00520+2.7.7.27|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 Gene3D G3DSA:3.90.550.10 8 329 1.8E-74 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 SUPERFAMILY SSF53448 3 273 8.79E-74 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 Gene3D G3DSA:2.160.10.10 330 422 1.1E-4 T 21-04-2016 SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 Pfam PF00483 Nucleotidyl transferase 7 270 1.6E-63 T 21-04-2016 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 Reactome: REACT_17015 SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 ProSitePatterns PS00808 ADP-glucose pyrophosphorylase signature 1. 11 30 - T 21-04-2016 IPR005836 ADP-glucose pyrophosphorylase, conserved site GO:0005978|GO:0008878 KEGG: 00500+2.7.7.27|KEGG: 00520+2.7.7.27|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS25280 3e3fe8c3c17f7d993020fc2386c81ee8 423 ProSitePatterns PS00809 ADP-glucose pyrophosphorylase signature 2. 97 105 - T 21-04-2016 IPR005836 ADP-glucose pyrophosphorylase, conserved site GO:0005978|GO:0008878 KEGG: 00500+2.7.7.27|KEGG: 00520+2.7.7.27|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Pfam PF00691 OmpA family 535 630 3.9E-22 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Gene3D G3DSA:3.30.1330.60 526 637 1.0E-37 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 SUPERFAMILY SSF48452 35 155 3.8E-12 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Gene3D G3DSA:1.25.40.10 27 154 1.9E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 ProSitePatterns PS01068 OmpA-like domain. 568 612 - T 21-04-2016 IPR006690 Outer membrane protein, OmpA-like, conserved site GO:0009279|GO:0016021 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Pfam PF07676 WD40-like Beta Propeller Repeat 329 367 5.9E-4 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Pfam PF07676 WD40-like Beta Propeller Repeat 222 260 0.027 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Pfam PF07676 WD40-like Beta Propeller Repeat 170 205 0.006 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Pfam PF07676 WD40-like Beta Propeller Repeat 396 421 0.018 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Pfam PF07676 WD40-like Beta Propeller Repeat 274 312 8.2E-11 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 SUPERFAMILY SSF82171 176 420 4.32E-18 T 21-04-2016 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 SUPERFAMILY SSF103088 527 636 2.35E-33 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 Gene3D G3DSA:2.120.10.30 173 420 4.2E-19 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 PANTHER PTHR30128 530 640 3.8E-41 T 21-04-2016 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 SMART SM00028 102 135 170.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 SMART SM00028 67 100 0.048 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 PRINTS PR01021 OMPA domain signature 566 581 7.5E-7 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 PRINTS PR01021 OMPA domain signature 581 597 7.5E-7 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS16380 06a240b23542d21fafc55409b7cfd0bd 643 PRINTS PR01021 OMPA domain signature 536 558 7.5E-7 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS12990 288991f980aed8680e2be2069efc733c 224 SUPERFAMILY SSF141318 49 209 8.37E-21 T 21-04-2016 SPH21_RS12990 288991f980aed8680e2be2069efc733c 224 Pfam PF10054 Predicted periplasmic lipoprotein (DUF2291) 21 209 8.2E-31 T 21-04-2016 IPR014582 Uncharacterised conserved protein UCP033535, periplasmic lipoprotein SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 PANTHER PTHR22773:SF49 1 507 1.9E-157 T 21-04-2016 SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 Pfam PF00361 Proton-conducting membrane transporter 134 426 1.9E-62 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 330 349 1.7E-17 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 241 265 1.7E-17 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 382 408 1.7E-17 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 169 193 1.7E-17 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 139 158 1.7E-17 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS14990 bddad877cdd31825717cd5c7288d2664 507 PANTHER PTHR22773 1 507 1.9E-157 T 21-04-2016 SPH21_RS03270 00162a622e2b1e4f354871ea4a8c0fa0 204 PANTHER PTHR32479:SF11 71 203 8.8E-22 T 21-04-2016 SPH21_RS03270 00162a622e2b1e4f354871ea4a8c0fa0 204 PANTHER PTHR32479 71 203 8.8E-22 T 21-04-2016 SPH21_RS03270 00162a622e2b1e4f354871ea4a8c0fa0 204 Gene3D G3DSA:3.40.50.10420 31 202 1.6E-33 T 21-04-2016 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SPH21_RS03270 00162a622e2b1e4f354871ea4a8c0fa0 204 SUPERFAMILY SSF100950 31 202 1.67E-27 T 21-04-2016 SPH21_RS03270 00162a622e2b1e4f354871ea4a8c0fa0 204 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 36 201 8.0E-13 T 21-04-2016 IPR003741 LUD domain SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 614 699 8.4E-11 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 52 178 1.2E-9 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 345 606 2.7E-38 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Gene3D G3DSA:3.30.365.10 472 497 3.9E-6 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Gene3D G3DSA:3.30.365.10 338 366 3.9E-6 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Gene3D G3DSA:3.30.365.10 545 746 1.5E-39 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Gene3D G3DSA:3.30.365.10 367 469 4.5E-28 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Gene3D G3DSA:3.90.1170.50 179 303 2.2E-20 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 Gene3D G3DSA:3.30.365.10 52 176 9.7E-32 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 SUPERFAMILY SSF56003 20 244 1.53E-34 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 SUPERFAMILY SSF56003 350 746 6.67E-98 T 21-04-2016 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 PIRSF PIRSF036389 1 752 4.0E-194 T 21-04-2016 IPR012368 Oxidoreductase molybdopterin-binding subunit, IorB-related SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 SMART SM01008 210 305 8.6E-24 T 21-04-2016 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 PANTHER PTHR11908:SF2 345 749 7.7E-125 T 21-04-2016 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 PANTHER PTHR11908:SF2 82 325 7.7E-125 T 21-04-2016 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 PANTHER PTHR11908 345 749 7.7E-125 T 21-04-2016 SPH21_RS00665 a32046cc0222c598a831b8540415ef54 752 PANTHER PTHR11908 82 325 7.7E-125 T 21-04-2016 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SUPERFAMILY SSF48452 182 302 4.87E-15 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SMART SM00028 67 100 71.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SMART SM00028 106 139 180.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SMART SM00028 146 179 17.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SMART SM00028 186 219 0.026 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SMART SM00028 266 299 380.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SMART SM00028 226 259 0.14 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 Pfam PF13424 Tetratricopeptide repeat 186 248 5.2E-11 T 21-04-2016 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SUPERFAMILY SSF48452 63 221 2.66E-20 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 SUPERFAMILY SSF46894 477 540 2.82E-6 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 PANTHER PTHR10098 57 247 4.0E-19 T 21-04-2016 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 PANTHER PTHR10098 522 534 4.0E-19 T 21-04-2016 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 Gene3D G3DSA:1.25.40.10 59 175 1.3E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22900 bb41c920eed2d78d1c8800040717d938 544 Gene3D G3DSA:1.25.40.10 176 329 2.4E-18 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 PRINTS PR00111 Alpha/beta hydrolase fold signature 103 116 2.3E-8 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 PRINTS PR00111 Alpha/beta hydrolase fold signature 45 60 2.3E-8 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 PRINTS PR00111 Alpha/beta hydrolase fold signature 89 102 2.3E-8 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 PRINTS PR00111 Alpha/beta hydrolase fold signature 200 214 2.3E-8 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 PANTHER PTHR10992:SF771 2 254 6.7E-56 T 21-04-2016 SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 Pfam PF12697 Alpha/beta hydrolase family 22 249 2.4E-19 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 SUPERFAMILY SSF53474 2 255 8.04E-59 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 Gene3D G3DSA:3.40.50.1820 3 255 1.6E-58 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22780 91b114921f2b4bde1508f9082d5970a7 256 PANTHER PTHR10992 2 254 6.7E-56 T 21-04-2016 SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 SUPERFAMILY SSF52540 1 175 5.32E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 PIRSF PIRSF006755 2 213 7.7E-38 T 21-04-2016 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 PANTHER PTHR21343:SF0 1 183 1.1E-40 T 21-04-2016 SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 Pfam PF13500 AAA domain 4 187 1.4E-43 T 21-04-2016 SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 Gene3D G3DSA:3.40.50.300 3 192 1.7E-47 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 TIGRFAM TIGR00347 bioD: dethiobiotin synthase 7 161 6.2E-32 T 21-04-2016 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 PANTHER PTHR21343 1 183 1.1E-40 T 21-04-2016 SPH21_RS16505 d922cf8a4a9ca7df48b0697f9b77ebe1 216 Hamap MF_00336 ATP-dependent dethiobiotin synthetase BioD [bioD]. 3 198 23.314 T 21-04-2016 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 Gene3D G3DSA:3.40.640.10 17 254 1.2E-90 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 PANTHER PTHR11601:SF45 5 379 3.1E-163 T 21-04-2016 SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 PIRSF PIRSF005572 3 383 1.7E-122 T 21-04-2016 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 Gene3D G3DSA:3.90.1150.10 255 375 2.1E-38 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 ProSitePatterns PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 196 215 - T 21-04-2016 IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 SUPERFAMILY SSF53383 6 380 9.47E-103 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 PANTHER PTHR11601 5 379 3.1E-163 T 21-04-2016 SPH21_RS18630 b0eeb7b9afea16c5304c79e3aa1aba53 395 Pfam PF00266 Aminotransferase class-V 6 367 9.7E-82 T 21-04-2016 IPR000192 Aminotransferase class V domain SPH21_RS26275 f725b75d80d3f7c5be40ef025bebb04a 345 SUPERFAMILY SSF49299 37 116 2.75E-15 T 21-04-2016 IPR000601 PKD domain SPH21_RS26275 f725b75d80d3f7c5be40ef025bebb04a 345 Pfam PF00801 PKD domain 38 101 1.6E-6 T 21-04-2016 IPR000601 PKD domain SPH21_RS26275 f725b75d80d3f7c5be40ef025bebb04a 345 SMART SM00089 39 117 7.8E-5 T 21-04-2016 IPR022409 PKD/Chitinase domain SPH21_RS26275 f725b75d80d3f7c5be40ef025bebb04a 345 Pfam PF00754 F5/8 type C domain 220 329 5.9E-8 T 21-04-2016 IPR000421 Coagulation factor 5/8 C-terminal domain SPH21_RS26275 f725b75d80d3f7c5be40ef025bebb04a 345 Gene3D G3DSA:2.60.120.260 214 340 2.4E-13 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS26275 f725b75d80d3f7c5be40ef025bebb04a 345 Gene3D G3DSA:2.60.40.670 36 116 2.8E-15 T 21-04-2016 IPR000601 PKD domain SPH21_RS26275 f725b75d80d3f7c5be40ef025bebb04a 345 SUPERFAMILY SSF49785 220 338 2.76E-12 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS13780 0f5c7c652eb4e9b0936bb716496fe7fc 313 Gene3D G3DSA:3.50.30.40 86 243 1.2E-31 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS13780 0f5c7c652eb4e9b0936bb716496fe7fc 313 Pfam PF03737 Demethylmenaquinone methyltransferase 86 234 1.2E-17 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS13780 0f5c7c652eb4e9b0936bb716496fe7fc 313 SUPERFAMILY SSF89562 83 242 7.33E-22 T 21-04-2016 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 PANTHER PTHR22976:SF19 8 319 3.1E-170 T 21-04-2016 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 SMART SM00729 47 260 2.1E-38 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 SMART SM00876 225 319 5.4E-34 T 21-04-2016 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 Gene3D G3DSA:3.20.20.70 9 319 1.1E-92 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 Pfam PF06968 Biotin and Thiamin Synthesis associated domain 225 317 7.1E-17 T 21-04-2016 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 PIRSF PIRSF001619 1 326 3.6E-129 T 21-04-2016 IPR024177 Biotin synthase KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 SUPERFAMILY SSF102114 9 317 2.09E-82 T 21-04-2016 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 TIGRFAM TIGR00433 bioB: biotin synthase 19 317 9.0E-113 T 21-04-2016 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 Hamap MF_01694 Biotin synthase [bioB]. 9 320 39.409 T 21-04-2016 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 PANTHER PTHR22976 8 319 3.1E-170 T 21-04-2016 SPH21_RS16510 af36ad883b6b2e0467cacc02f5a37290 331 Pfam PF04055 Radical SAM superfamily 54 211 2.7E-13 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS10990 9c983aed0196513ae9a4b29afd887ef7 139 Pfam PF06170 Protein of unknown function (DUF983) 38 112 1.1E-4 T 21-04-2016 IPR009325 Protein of unknown function DUF983 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 PANTHER PTHR11532:SF57 656 1111 2.2E-231 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 PANTHER PTHR11532:SF57 557 628 2.2E-231 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 PANTHER PTHR11532:SF57 121 484 2.2E-231 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 127 1113 6.4E-246 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 PANTHER PTHR11532 656 1111 2.2E-231 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 PANTHER PTHR11532 557 628 2.2E-231 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 PANTHER PTHR11532 121 484 2.2E-231 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 SUPERFAMILY SSF56935 530 865 1.21E-89 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 SUPERFAMILY SSF56935 208 350 1.21E-89 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 SUPERFAMILY SSF56935 937 981 1.21E-89 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 SUPERFAMILY SSF56935 406 495 1.21E-89 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 SUPERFAMILY SSF56935 1022 1113 1.21E-89 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 SUPERFAMILY SSF49464 126 212 5.36E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Pfam PF00593 TonB dependent receptor 700 1111 4.9E-19 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Gene3D G3DSA:2.40.170.20 1011 1113 1.9E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Gene3D G3DSA:2.40.170.20 329 350 1.9E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Gene3D G3DSA:2.40.170.20 946 971 1.9E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Gene3D G3DSA:2.40.170.20 415 886 1.9E-48 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Pfam PF13715 CarboxypepD_reg-like domain 127 211 4.2E-18 T 21-04-2016 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Gene3D G3DSA:2.60.40.1120 126 216 1.8E-18 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 301 331 5.9E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Gene3D G3DSA:2.170.130.10 218 328 2.0E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS03970 60b7a987be4781b564e6d05c70ab2f27 1114 Pfam PF07715 TonB-dependent Receptor Plug Domain 219 325 8.1E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09480 219ede63448222c3b434232ab69090c2 333 Pfam PF04773 FecR protein 124 217 5.5E-15 T 21-04-2016 IPR006860 FecR protein SPH21_RS09480 219ede63448222c3b434232ab69090c2 333 Pfam PF16344 Domain of unknown function (DUF4974) 227 325 1.1E-18 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS09480 219ede63448222c3b434232ab69090c2 333 PANTHER PTHR30273:SF2 1 332 5.0E-65 T 21-04-2016 SPH21_RS09480 219ede63448222c3b434232ab69090c2 333 PIRSF PIRSF018266 1 330 2.5E-57 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09480 219ede63448222c3b434232ab69090c2 333 Gene3D G3DSA:3.40.430.10 251 303 6.8E-4 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS09480 219ede63448222c3b434232ab69090c2 333 PANTHER PTHR30273 1 332 5.0E-65 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS11530 a68d4b9a7d1dccb7e7d0f05a852e9d6c 720 SUPERFAMILY SSF48208 290 669 2.15E-49 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS11530 a68d4b9a7d1dccb7e7d0f05a852e9d6c 720 Gene3D G3DSA:2.60.120.260 182 288 2.1E-29 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11530 a68d4b9a7d1dccb7e7d0f05a852e9d6c 720 PANTHER PTHR34987 25 661 5.1E-155 T 21-04-2016 SPH21_RS11530 a68d4b9a7d1dccb7e7d0f05a852e9d6c 720 Pfam PF05592 Bacterial alpha-L-rhamnosidase 194 668 1.3E-45 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS11530 a68d4b9a7d1dccb7e7d0f05a852e9d6c 720 Gene3D G3DSA:2.60.120.260 24 180 4.1E-69 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11530 a68d4b9a7d1dccb7e7d0f05a852e9d6c 720 PANTHER PTHR34987:SF1 25 661 5.1E-155 T 21-04-2016 SPH21_RS24910 2348fe2d88e203e200a6f7e98da590fe 385 PANTHER PTHR22925 150 365 1.3E-50 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS24910 2348fe2d88e203e200a6f7e98da590fe 385 PANTHER PTHR22925 51 132 1.3E-50 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS24910 2348fe2d88e203e200a6f7e98da590fe 385 Gene3D G3DSA:2.115.10.20 50 369 1.6E-42 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS24910 2348fe2d88e203e200a6f7e98da590fe 385 SUPERFAMILY SSF75005 50 367 2.67E-36 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS24910 2348fe2d88e203e200a6f7e98da590fe 385 Pfam PF04616 Glycosyl hydrolases family 43 52 364 5.4E-20 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS24910 2348fe2d88e203e200a6f7e98da590fe 385 PANTHER PTHR22925:SF40 150 365 1.3E-50 T 21-04-2016 SPH21_RS24910 2348fe2d88e203e200a6f7e98da590fe 385 PANTHER PTHR22925:SF40 51 132 1.3E-50 T 21-04-2016 SPH21_RS14065 2ebd988d6e20d5f8382f21008dfa8480 405 PANTHER PTHR30158 13 398 2.5E-102 T 21-04-2016 SPH21_RS14065 2ebd988d6e20d5f8382f21008dfa8480 405 Gene3D G3DSA:2.40.50.100 81 114 2.1E-19 T 21-04-2016 SPH21_RS14065 2ebd988d6e20d5f8382f21008dfa8480 405 Gene3D G3DSA:2.40.50.100 189 220 2.1E-19 T 21-04-2016 SPH21_RS14065 2ebd988d6e20d5f8382f21008dfa8480 405 SUPERFAMILY SSF111369 68 314 4.05E-54 T 21-04-2016 SPH21_RS14065 2ebd988d6e20d5f8382f21008dfa8480 405 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 58 390 2.6E-79 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS14065 2ebd988d6e20d5f8382f21008dfa8480 405 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 82 307 4.5E-13 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS09985 34cbb547066449f37fdd0c05aeacf918 297 PANTHER PTHR22916 1 255 1.5E-41 T 21-04-2016 SPH21_RS09985 34cbb547066449f37fdd0c05aeacf918 297 SUPERFAMILY SSF53448 1 210 5.23E-47 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09985 34cbb547066449f37fdd0c05aeacf918 297 Pfam PF00535 Glycosyl transferase family 2 3 126 1.8E-30 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS09985 34cbb547066449f37fdd0c05aeacf918 297 Gene3D G3DSA:3.90.550.10 2 229 5.0E-47 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 PANTHER PTHR30524 29 419 5.8E-112 T 21-04-2016 SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 PANTHER PTHR30524 436 504 5.8E-112 T 21-04-2016 SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 SUPERFAMILY SSF48179 288 505 6.46E-35 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 SUPERFAMILY SSF51735 12 268 3.62E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 PANTHER PTHR30524:SF1 29 419 5.8E-112 T 21-04-2016 SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 PANTHER PTHR30524:SF1 436 504 5.8E-112 T 21-04-2016 SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 Pfam PF08125 Mannitol dehydrogenase C-terminal domain 218 476 2.8E-42 T 21-04-2016 IPR013118 Mannitol dehydrogenase, C-terminal GO:0016491|GO:0050662|GO:0055114 SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 Gene3D G3DSA:1.10.1040.10 288 505 2.3E-49 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 Gene3D G3DSA:3.40.50.720 13 269 1.8E-61 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14380 94e8686715572d23ce44793c5acddb6d 513 Pfam PF01232 Mannitol dehydrogenase Rossmann domain 31 182 8.4E-14 T 21-04-2016 IPR013131 Mannitol dehydrogenase, N-terminal GO:0016491|GO:0055114 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 Hamap MF_00736 50S ribosomal protein L11 [rplK]. 5 141 30.824 T 21-04-2016 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 Gene3D G3DSA:1.10.10.250 72 139 1.1E-30 T 21-04-2016 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 SUPERFAMILY SSF54747 3 72 3.14E-28 T 21-04-2016 IPR020784 Ribosomal protein L11, N-terminal SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 Pfam PF00298 Ribosomal protein L11, RNA binding domain 71 139 2.0E-24 T 21-04-2016 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 PANTHER PTHR11661 1 144 7.7E-63 T 21-04-2016 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 ProSitePatterns PS00359 Ribosomal protein L11 signature. 126 141 - T 21-04-2016 IPR020785 Ribosomal protein L11, conserved site GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 ProDom PD001367 RIBOSOMAL RIBONUCLEOPROTEIN L11 RRNA-BINDING RNA-BINDING METHYLATION 50S L11 BACTERIAL CHLOROPLAST 36 73 8.0E-15 T 21-04-2016 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 Pfam PF03946 Ribosomal protein L11, N-terminal domain 9 66 3.0E-28 T 21-04-2016 IPR020784 Ribosomal protein L11, N-terminal SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 SUPERFAMILY SSF46906 67 139 1.96E-26 T 21-04-2016 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 TIGRFAM TIGR01632 L11_bact: ribosomal protein uL11 3 140 2.3E-63 T 21-04-2016 IPR006519 Ribosomal protein L11, bacterial-type GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 SMART SM00649 9 140 7.5E-75 T 21-04-2016 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 SPH21_RS11885 16e6a4a0f576fb181257bbca3599c4a8 147 Gene3D G3DSA:3.30.1550.10 2 71 1.0E-35 T 21-04-2016 IPR020784 Ribosomal protein L11, N-terminal SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 24 151 5.0E-17 T 21-04-2016 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PANTHER PTHR22600 9 514 2.8E-146 T 21-04-2016 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 470 487 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 452 468 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 302 315 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 111 131 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 239 256 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 178 199 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 280 298 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PRINTS PR00738 Glycosyl hydrolase family 20 signature 149 166 8.3E-50 T 21-04-2016 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 SUPERFAMILY SSF55545 13 153 1.44E-19 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 SUPERFAMILY SSF51445 155 501 1.22E-104 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 PANTHER PTHR22600:SF21 9 514 2.8E-146 T 21-04-2016 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 Gene3D G3DSA:3.30.379.10 2 152 3.6E-24 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 Gene3D G3DSA:3.20.20.80 153 503 7.1E-112 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS03210 80f81d6945b2b056d9911ddf412d8914 542 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 155 488 2.6E-100 T 21-04-2016 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SPH21_RS03055 aa55b2984ec4869e5d29a15bf9ac4eac 389 Pfam PF11175 Protein of unknown function (DUF2961) 125 370 9.4E-85 T 21-04-2016 IPR021345 Protein of unknown function DUF2961 SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 Pfam PF16124 RecQ zinc-binding 515 566 5.5E-10 T 21-04-2016 IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 SMART SM00487 12 204 4.0E-31 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 SMART SM00490 242 323 7.4E-26 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 PANTHER PTHR13710:SF81 3 342 3.7E-175 T 21-04-2016 SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 PANTHER PTHR13710:SF81 513 613 3.7E-175 T 21-04-2016 SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 Gene3D G3DSA:3.40.50.300 3 191 4.7E-56 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 Pfam PF00270 DEAD/DEAH box helicase 18 180 1.9E-21 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 TIGRFAM TIGR00614 recQ_fam: ATP-dependent DNA helicase, RecQ family 5 342 1.1E-117 T 21-04-2016 IPR004589 DNA helicase, ATP-dependent, RecQ type GO:0006310|GO:0008026 SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 Gene3D G3DSA:3.40.50.300 200 338 3.3E-42 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 Gene3D G3DSA:1.10.10.10 511 609 4.3E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 SUPERFAMILY SSF52540 56 342 3.74E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 Pfam PF00271 Helicase conserved C-terminal domain 219 323 8.0E-18 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 PANTHER PTHR13710 3 342 3.7E-175 T 21-04-2016 SPH21_RS14615 f9ff10c2b5117bf0fa2deb1d17e7c66f 633 PANTHER PTHR13710 513 613 3.7E-175 T 21-04-2016 SPH21_RS01775 d95e4b2c6970c55b40e60d941e33cb05 165 Gene3D G3DSA:1.20.120.450 3 149 2.0E-22 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS01775 d95e4b2c6970c55b40e60d941e33cb05 165 Pfam PF05163 DinB family 7 162 1.3E-9 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS01775 d95e4b2c6970c55b40e60d941e33cb05 165 SUPERFAMILY SSF109854 1 157 1.04E-29 T 21-04-2016 SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 PANTHER PTHR32125 1 225 5.4E-104 T 21-04-2016 SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 TIGRFAM TIGR00088 trmD: tRNA (guanine(37)-N(1))-methyltransferase 1 224 9.5E-88 T 21-04-2016 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 Gene3D G3DSA:3.40.1280.10 1 159 2.9E-66 T 21-04-2016 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 Gene3D G3DSA:1.10.1270.20 161 224 3.3E-27 T 21-04-2016 IPR023148 tRNA (guanine-N1-)-methyltransferase, C-terminal GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 SUPERFAMILY SSF75217 1 224 2.62E-94 T 21-04-2016 IPR029028 Alpha/beta knot methyltransferases SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 Pfam PF01746 tRNA (Guanine-1)-methyltransferase 23 220 1.3E-63 T 21-04-2016 IPR016009 tRNA methyltransferase TRMD/TRM10-type domain KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 PANTHER PTHR32125:SF1 1 225 5.4E-104 T 21-04-2016 SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 PIRSF PIRSF000386 1 225 2.0E-98 T 21-04-2016 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SPH21_RS06530 7918e825d3ec355eb3a9e94ef1974573 225 Hamap MF_00605 tRNA (guanine-N(1)-)-methyltransferase [trmD]. 1 225 98.948 T 21-04-2016 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SPH21_RS02555 2d6d45de5a3574f2cc39b0fc35a441f8 150 Gene3D G3DSA:3.40.630.30 1 141 1.3E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS02555 2d6d45de5a3574f2cc39b0fc35a441f8 150 SUPERFAMILY SSF55729 1 145 2.44E-28 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS02555 2d6d45de5a3574f2cc39b0fc35a441f8 150 PANTHER PTHR23091 1 141 8.6E-19 T 21-04-2016 SPH21_RS02555 2d6d45de5a3574f2cc39b0fc35a441f8 150 PANTHER PTHR23091:SF256 1 141 8.6E-19 T 21-04-2016 SPH21_RS02555 2d6d45de5a3574f2cc39b0fc35a441f8 150 Pfam PF00583 Acetyltransferase (GNAT) family 55 134 1.3E-11 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 SUPERFAMILY SSF51735 1 165 1.04E-71 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 PIRSF PIRSF000149 1 331 5.3E-133 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 154 311 2.9E-69 T 21-04-2016 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 1 149 6.7E-64 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 Gene3D G3DSA:3.30.360.10 158 313 1.8E-85 T 21-04-2016 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 SMART SM00846 1 149 1.2E-103 T 21-04-2016 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 ProSitePatterns PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 147 154 - T 21-04-2016 IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 Gene3D G3DSA:3.40.50.720 1 157 1.6E-81 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 PANTHER PTHR10836 1 325 1.0E-247 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 SUPERFAMILY SSF55347 148 311 3.87E-79 T 21-04-2016 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 227 244 6.3E-46 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 170 186 6.3E-46 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 267 282 6.3E-46 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 143 161 6.3E-46 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 107 120 6.3E-46 T 21-04-2016 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: REACT_474 SPH21_RS19325 9bca7472f41e2b180c130f21e02fb67b 331 TIGRFAM TIGR01534 GAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I 2 323 2.2E-137 T 21-04-2016 IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I GO:0006006|GO:0016620|GO:0050661|GO:0051287|GO:0055114 KEGG: 00010+1.2.1.12|KEGG: 00710+1.2.1.12|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: REACT_474|UniPathway: UPA00109 SPH21_RS05925 4441d5bf1144a5738ab74aa7fd984ab0 139 Gene3D G3DSA:3.40.50.1010 4 136 7.4E-7 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS05925 4441d5bf1144a5738ab74aa7fd984ab0 139 SUPERFAMILY SSF88723 1 124 7.85E-14 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS05925 4441d5bf1144a5738ab74aa7fd984ab0 139 Pfam PF13470 PIN domain 4 116 5.5E-7 T 21-04-2016 IPR002716 PIN domain SPH21_RS00605 fdf4941f71477647d9a13c3b43886f75 537 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 206 221 - T 21-04-2016 IPR019826 Carboxylesterase type B, active site SPH21_RS00605 fdf4941f71477647d9a13c3b43886f75 537 Gene3D G3DSA:3.40.50.1820 29 532 5.8E-137 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00605 fdf4941f71477647d9a13c3b43886f75 537 SUPERFAMILY SSF53474 29 514 5.7E-121 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00605 fdf4941f71477647d9a13c3b43886f75 537 ProSitePatterns PS00941 Carboxylesterases type-B signature 2. 105 115 - T 21-04-2016 IPR019819 Carboxylesterase type B, conserved site SPH21_RS00605 fdf4941f71477647d9a13c3b43886f75 537 PANTHER PTHR11559 3 515 2.1E-145 T 21-04-2016 SPH21_RS00605 fdf4941f71477647d9a13c3b43886f75 537 Pfam PF00135 Carboxylesterase family 29 514 7.7E-110 T 21-04-2016 IPR002018 Carboxylesterase, type B SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 Gene3D G3DSA:3.30.2080.10 575 704 1.7E-36 T 21-04-2016 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 SUPERFAMILY SSF48208 243 681 1.62E-15 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 Pfam PF07971 Glycosyl hydrolase family 92 228 704 9.0E-138 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 PANTHER PTHR12143 1 704 4.8E-124 T 21-04-2016 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 Gene3D G3DSA:1.20.1610.10 414 574 8.5E-55 T 21-04-2016 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 Gene3D G3DSA:2.70.98.10 17 307 5.1E-75 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 PANTHER PTHR12143:SF22 1 704 4.8E-124 T 21-04-2016 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 Gene3D G3DSA:1.20.1050.60 331 409 6.4E-13 T 21-04-2016 SPH21_RS22260 f454d4b2389917d73180a84370c2fdcc 706 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 8 704 9.3E-145 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 PANTHER PTHR30097 60 369 6.3E-57 T 21-04-2016 SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 PANTHER PTHR30097:SF4 60 369 6.3E-57 T 21-04-2016 SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 Gene3D G3DSA:1.20.1600.10 121 170 4.1E-4 T 21-04-2016 SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 SUPERFAMILY SSF111369 75 292 1.26E-16 T 21-04-2016 SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 79 355 4.5E-41 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 60 288 3.7E-41 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 Gene3D G3DSA:2.40.50.100 181 208 4.5E-9 T 21-04-2016 SPH21_RS19695 ea263594f604824c414c6aac4e3cda9d 369 Gene3D G3DSA:2.40.50.100 79 108 4.5E-9 T 21-04-2016 SPH21_RS10020 15c94491f0849584c1afea115be6548a 353 Pfam PF13439 Glycosyltransferase Family 4 17 166 1.5E-7 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS10020 15c94491f0849584c1afea115be6548a 353 PANTHER PTHR12526:SF399 4 350 3.1E-50 T 21-04-2016 SPH21_RS10020 15c94491f0849584c1afea115be6548a 353 Gene3D G3DSA:3.40.50.2000 185 328 1.6E-20 T 21-04-2016 SPH21_RS10020 15c94491f0849584c1afea115be6548a 353 SUPERFAMILY SSF53756 14 352 6.8E-61 T 21-04-2016 SPH21_RS10020 15c94491f0849584c1afea115be6548a 353 PANTHER PTHR12526 4 350 3.1E-50 T 21-04-2016 SPH21_RS10020 15c94491f0849584c1afea115be6548a 353 Pfam PF00534 Glycosyl transferases group 1 178 320 1.0E-26 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Gene3D G3DSA:2.60.40.1120 153 237 9.3E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Pfam PF13715 CarboxypepD_reg-like domain 154 234 2.5E-15 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Gene3D G3DSA:2.40.170.20 1059 1156 2.4E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Gene3D G3DSA:2.40.170.20 984 1009 2.4E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Gene3D G3DSA:2.40.170.20 449 910 2.4E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Gene3D G3DSA:2.40.170.20 358 387 2.4E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 SUPERFAMILY SSF56935 1062 1156 1.03E-96 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 SUPERFAMILY SSF56935 975 1019 1.03E-96 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 SUPERFAMILY SSF56935 560 900 1.03E-96 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 SUPERFAMILY SSF56935 230 380 1.03E-96 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 SUPERFAMILY SSF56935 440 528 1.03E-96 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 PANTHER PTHR11532:SF57 600 662 7.5E-245 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 PANTHER PTHR11532:SF57 147 494 7.5E-245 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 PANTHER PTHR11532:SF57 688 1154 7.5E-245 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 153 1156 5.5E-263 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 PANTHER PTHR11532 600 662 7.5E-245 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 PANTHER PTHR11532 147 494 7.5E-245 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 PANTHER PTHR11532 688 1154 7.5E-245 T 21-04-2016 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Gene3D G3DSA:2.170.130.10 238 357 1.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 332 362 4.2E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 SUPERFAMILY SSF49464 152 232 1.31E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02265 746221ba8a5d1487cb8fbadbe12c81c7 1156 Pfam PF07715 TonB-dependent Receptor Plug Domain 243 356 4.9E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24985 88313a99aca9adb9b56085f52e670452 116 Pfam PF09966 Uncharacterized protein conserved in bacteria (DUF2200) 5 115 1.3E-56 T 21-04-2016 IPR014580 Uncharacterised conserved protein UCP033199 SPH21_RS24985 88313a99aca9adb9b56085f52e670452 116 PIRSF PIRSF033199 1 116 7.3E-62 T 21-04-2016 IPR014580 Uncharacterised conserved protein UCP033199 SPH21_RS24985 88313a99aca9adb9b56085f52e670452 116 Gene3D G3DSA:1.10.8.290 1 116 1.1E-60 T 21-04-2016 IPR023204 SP1917 domain SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 PANTHER PTHR30572 287 356 1.2E-72 T 21-04-2016 SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 PANTHER PTHR30572 402 802 1.2E-72 T 21-04-2016 SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 Pfam PF02687 FtsX-like permease family 682 788 8.5E-9 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 Pfam PF02687 FtsX-like permease family 291 403 2.5E-17 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 PANTHER PTHR30572:SF4 287 356 1.2E-72 T 21-04-2016 SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 PANTHER PTHR30572:SF4 402 802 1.2E-72 T 21-04-2016 SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 Pfam PF12704 MacB-like periplasmic core domain 454 604 2.9E-7 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS06025 a42aeb28666ac9752caf3118cd21d536 802 Pfam PF12704 MacB-like periplasmic core domain 20 236 2.4E-18 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS17495 ba85fb5b91f9feb660686a97012c5b87 251 SUPERFAMILY SSF52540 5 231 1.96E-74 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17495 ba85fb5b91f9feb660686a97012c5b87 251 Pfam PF00005 ABC transporter 25 173 3.8E-35 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS17495 ba85fb5b91f9feb660686a97012c5b87 251 Gene3D G3DSA:3.40.50.300 4 223 2.4E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17495 ba85fb5b91f9feb660686a97012c5b87 251 PANTHER PTHR24220 7 225 2.7E-122 T 21-04-2016 SPH21_RS17495 ba85fb5b91f9feb660686a97012c5b87 251 PANTHER PTHR24220:SF578 7 225 2.7E-122 T 21-04-2016 SPH21_RS17495 ba85fb5b91f9feb660686a97012c5b87 251 ProSitePatterns PS00211 ABC transporters family signature. 146 160 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS17495 ba85fb5b91f9feb660686a97012c5b87 251 SMART SM00382 34 228 1.4E-14 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS04270 70f718a2b20bcb464401185a00f54308 206 Pfam PF13649 Methyltransferase domain 47 132 7.0E-10 T 21-04-2016 SPH21_RS04270 70f718a2b20bcb464401185a00f54308 206 SUPERFAMILY SSF53335 4 196 3.09E-23 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS04270 70f718a2b20bcb464401185a00f54308 206 Gene3D G3DSA:3.40.50.150 5 201 6.9E-21 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 PANTHER PTHR33154:SF6 11 109 5.6E-17 T 21-04-2016 SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 Gene3D G3DSA:1.10.10.10 5 96 1.1E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 68 83 5.8E-8 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 53 68 5.8E-8 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 20 35 5.8E-8 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 SUPERFAMILY SSF46785 10 95 1.31E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 SMART SM00418 18 100 2.9E-14 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 Pfam PF01022 Bacterial regulatory protein, arsR family 25 70 4.1E-11 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS23580 ff9aaef0f7383369931e7e92a290b9c1 109 PANTHER PTHR33154 11 109 5.6E-17 T 21-04-2016 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 PANTHER PTHR30146 10 344 1.6E-95 T 21-04-2016 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 SMART SM00354 10 80 3.0E-26 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 SUPERFAMILY SSF47413 11 69 2.44E-17 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 SUPERFAMILY SSF53822 70 344 1.96E-61 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 Pfam PF13377 Periplasmic binding protein-like domain 181 344 2.2E-31 T 21-04-2016 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 Pfam PF00356 Bacterial regulatory proteins, lacI family 13 57 6.4E-15 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 Gene3D G3DSA:3.40.50.2300 63 184 1.1E-35 T 21-04-2016 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 Gene3D G3DSA:1.10.260.40 12 62 2.6E-23 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS03610 81a98c6c9d63f52a5086bbc88feceb0b 344 Gene3D G3DSA:3.40.50.2300 185 322 4.7E-39 T 21-04-2016 SPH21_RS09755 79d071d4b852824b2d4df090941c466f 566 Pfam PF14322 Starch-binding associating with outer membrane 25 238 5.5E-14 T 21-04-2016 SPH21_RS09755 79d071d4b852824b2d4df090941c466f 566 Gene3D G3DSA:1.25.40.10 221 324 1.4E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09755 79d071d4b852824b2d4df090941c466f 566 Gene3D G3DSA:1.25.40.10 390 491 1.4E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09755 79d071d4b852824b2d4df090941c466f 566 Pfam PF07980 SusD family 285 566 2.2E-57 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09755 79d071d4b852824b2d4df090941c466f 566 SUPERFAMILY SSF48452 21 566 2.02E-115 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 Hamap MF_00223 GTP cyclohydrolase 1 [folE]. 28 209 37.835 T 21-04-2016 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|UniPathway: UPA00848 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 ProSitePatterns PS00860 GTP cyclohydrolase I signature 2. 137 147 - T 21-04-2016 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|UniPathway: UPA00848 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 TIGRFAM TIGR00063 folE: GTP cyclohydrolase I 32 208 1.5E-74 T 21-04-2016 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|UniPathway: UPA00848 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 PANTHER PTHR11109 28 208 1.8E-107 T 21-04-2016 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|UniPathway: UPA00848 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 Gene3D G3DSA:1.10.286.10 29 79 2.1E-19 T 21-04-2016 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 Pfam PF01227 GTP cyclohydrolase I 32 208 1.0E-75 T 21-04-2016 IPR020602 GTP cyclohydrolase I domain KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|UniPathway: UPA00848 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 ProSitePatterns PS00859 GTP cyclohydrolase I signature 1. 89 105 - T 21-04-2016 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|UniPathway: UPA00848 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 Gene3D G3DSA:3.30.1130.10 82 209 5.9E-61 T 21-04-2016 SPH21_RS06490 3dc48fe6f926c01be30f0453590d6cd2 213 SUPERFAMILY SSF55620 24 209 1.63E-76 T 21-04-2016 SPH21_RS01965 7fffcedf82e709281d3cd92b271b25c4 402 Pfam PF13635 Domain of unknown function (DUF4143) 203 337 7.7E-11 T 21-04-2016 IPR025420 Domain of unknown function DUF4143 SPH21_RS01965 7fffcedf82e709281d3cd92b271b25c4 402 PANTHER PTHR33295:SF6 39 400 4.1E-103 T 21-04-2016 SPH21_RS01965 7fffcedf82e709281d3cd92b271b25c4 402 Gene3D G3DSA:3.40.50.300 40 148 1.5E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01965 7fffcedf82e709281d3cd92b271b25c4 402 Pfam PF13173 AAA domain 39 159 1.6E-32 T 21-04-2016 SPH21_RS01965 7fffcedf82e709281d3cd92b271b25c4 402 PANTHER PTHR33295 39 400 4.1E-103 T 21-04-2016 SPH21_RS01965 7fffcedf82e709281d3cd92b271b25c4 402 SUPERFAMILY SSF52540 39 189 3.48E-18 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 Gene3D G3DSA:2.160.20.10 183 366 3.2E-16 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 Gene3D G3DSA:2.160.20.10 51 146 3.2E-16 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 Pfam PF13229 Right handed beta helix region 187 353 3.8E-8 T 21-04-2016 SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 SUPERFAMILY SSF51126 183 339 1.54E-20 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 SUPERFAMILY SSF51126 56 146 1.54E-20 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 SMART SM00710 190 212 9.7 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 SMART SM00710 300 321 7900.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 SMART SM00710 326 367 3400.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS09035 26e88b31e8c7c5b0dc8730a576ac6a86 387 SMART SM00710 214 240 110.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS21170 41db911d28c548c7ffc98ba83f3bcece 156 Gene3D G3DSA:3.40.1400.10 1 149 1.1E-52 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS21170 41db911d28c548c7ffc98ba83f3bcece 156 Pfam PF02502 Ribose/Galactose Isomerase 3 142 7.3E-46 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS21170 41db911d28c548c7ffc98ba83f3bcece 156 TIGRFAM TIGR00689 rpiB_lacA_lacB: sugar-phosphate isomerase, RpiB/LacA/LacB family 4 147 3.4E-44 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS21170 41db911d28c548c7ffc98ba83f3bcece 156 PIRSF PIRSF005384 1 148 2.4E-50 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS21170 41db911d28c548c7ffc98ba83f3bcece 156 PANTHER PTHR30345 1 150 6.9E-60 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS21170 41db911d28c548c7ffc98ba83f3bcece 156 SUPERFAMILY SSF89623 1 148 5.49E-48 T 21-04-2016 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26|UniPathway: UPA00702 SPH21_RS21215 070641db0b61d14841da64f4c3871956 790 PANTHER PTHR31151 22 642 5.0E-175 T 21-04-2016 SPH21_RS21215 070641db0b61d14841da64f4c3871956 790 SUPERFAMILY SSF48208 164 423 9.35E-23 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS21215 070641db0b61d14841da64f4c3871956 790 SUPERFAMILY SSF48208 85 129 9.35E-23 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS21215 070641db0b61d14841da64f4c3871956 790 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 41 549 1.5E-146 T 21-04-2016 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS21215 070641db0b61d14841da64f4c3871956 790 PANTHER PTHR31151:SF0 22 642 5.0E-175 T 21-04-2016 SPH21_RS21215 070641db0b61d14841da64f4c3871956 790 Pfam PF16375 Domain of unknown function 553 636 1.3E-28 T 21-04-2016 IPR032275 Domain of unknown function DUF4986 SPH21_RS14980 6aa2b13394f8342a90f4f0d52f426d65 135 PANTHER PTHR33932 1 132 9.6E-21 T 21-04-2016 SPH21_RS14980 6aa2b13394f8342a90f4f0d52f426d65 135 Pfam PF04039 Domain related to MnhB subunit of Na+/H+ antiporter 5 126 4.5E-30 T 21-04-2016 IPR007182 Na+/H+ antiporter MnhB subunit-related protein SPH21_RS14980 6aa2b13394f8342a90f4f0d52f426d65 135 PANTHER PTHR33932:SF4 1 132 9.6E-21 T 21-04-2016 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 Pfam PF01119 DNA mismatch repair protein, C-terminal domain 209 326 2.9E-38 T 21-04-2016 IPR013507 DNA mismatch repair protein, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 26 128 3.0E-10 T 21-04-2016 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 Gene3D G3DSA:3.30.565.10 5 204 5.2E-71 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 SUPERFAMILY SSF55874 5 212 1.44E-50 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 Gene3D G3DSA:3.30.230.10 205 326 2.5E-37 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 TIGRFAM TIGR00585 mutl: DNA mismatch repair protein MutL 5 306 1.4E-95 T 21-04-2016 IPR002099 DNA mismatch repair protein family GO:0005524|GO:0006298|GO:0030983 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 Pfam PF08676 MutL C terminal dimerisation domain 432 578 2.5E-28 T 21-04-2016 IPR014790 MutL, C-terminal, dimerisation GO:0005524|GO:0006298 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 SUPERFAMILY SSF54211 193 327 1.02E-35 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 SMART SM00853 435 578 9.9E-33 T 21-04-2016 IPR014790 MutL, C-terminal, dimerisation GO:0005524|GO:0006298 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 SMART SM01340 209 327 1.1E-52 T 21-04-2016 IPR013507 DNA mismatch repair protein, C-terminal GO:0005524|GO:0006298|GO:0030983 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 Hamap MF_00149 DNA mismatch repair protein MutL [mutL]. 3 618 24.555 T 21-04-2016 IPR020667 DNA mismatch repair protein, MutL GO:0006298 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 SUPERFAMILY SSF118116 431 619 8.89E-38 T 21-04-2016 SPH21_RS07280 f08747df972d6ce567789fca99f73988 620 PANTHER PTHR10073 5 596 8.7E-143 T 21-04-2016 SPH21_RS10745 2b8e03c9aa0f5da31d2c275e1633225c 176 Gene3D G3DSA:1.20.1260.10 42 145 6.4E-7 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS10745 2b8e03c9aa0f5da31d2c275e1633225c 176 Pfam PF13628 Domain of unknown function (DUF4142) 33 170 3.2E-38 T 21-04-2016 IPR025419 Domain of unknown function DUF4142 SPH21_RS10745 2b8e03c9aa0f5da31d2c275e1633225c 176 PANTHER PTHR38593 23 170 3.4E-15 T 21-04-2016 SPH21_RS10745 2b8e03c9aa0f5da31d2c275e1633225c 176 PANTHER PTHR38593:SF2 23 170 3.4E-15 T 21-04-2016 SPH21_RS15830 5b6495b902a6a6505aeeecba583dfb7b 163 TIGRFAM TIGR01957 nuoB_fam: NADH-quinone oxidoreductase, B subunit 11 152 9.2E-70 T 21-04-2016 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 SPH21_RS15830 5b6495b902a6a6505aeeecba583dfb7b 163 PANTHER PTHR11995:SF14 6 161 1.7E-87 T 21-04-2016 SPH21_RS15830 5b6495b902a6a6505aeeecba583dfb7b 163 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 37 146 2.6E-23 T 21-04-2016 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 SPH21_RS15830 5b6495b902a6a6505aeeecba583dfb7b 163 Hamap MF_01356 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic [ndhK]. 1 152 39.685 T 21-04-2016 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 SPH21_RS15830 5b6495b902a6a6505aeeecba583dfb7b 163 SUPERFAMILY SSF56770 9 156 1.06E-64 T 21-04-2016 SPH21_RS15830 5b6495b902a6a6505aeeecba583dfb7b 163 Gene3D G3DSA:3.40.50.700 21 150 7.1E-32 T 21-04-2016 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 SPH21_RS15830 5b6495b902a6a6505aeeecba583dfb7b 163 PANTHER PTHR11995 6 161 1.7E-87 T 21-04-2016 SPH21_RS16455 f9a60d4af0c9a2b479e9338e52c78fa4 163 Gene3D G3DSA:1.10.10.10 13 146 4.5E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16455 f9a60d4af0c9a2b479e9338e52c78fa4 163 SMART SM00347 33 130 3.9E-5 T 21-04-2016 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SPH21_RS16455 f9a60d4af0c9a2b479e9338e52c78fa4 163 PANTHER PTHR33164 9 153 4.2E-17 T 21-04-2016 SPH21_RS16455 f9a60d4af0c9a2b479e9338e52c78fa4 163 SUPERFAMILY SSF46785 12 147 2.22E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16455 f9a60d4af0c9a2b479e9338e52c78fa4 163 Pfam PF12802 MarR family 45 94 2.4E-7 T 21-04-2016 SPH21_RS20775 522b9ed743c6553f3a60952f686bfb9b 289 PANTHER PTHR14194:SF73 2 287 1.6E-72 T 21-04-2016 SPH21_RS20775 522b9ed743c6553f3a60952f686bfb9b 289 PANTHER PTHR14194 2 287 1.6E-72 T 21-04-2016 SPH21_RS20775 522b9ed743c6553f3a60952f686bfb9b 289 Gene3D G3DSA:3.40.50.720 2 223 5.0E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20775 522b9ed743c6553f3a60952f686bfb9b 289 SUPERFAMILY SSF51735 2 254 1.34E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20775 522b9ed743c6553f3a60952f686bfb9b 289 Pfam PF05368 NmrA-like family 2 226 2.5E-22 T 21-04-2016 IPR008030 NmrA-like domain SPH21_RS13940 060a39d2c4b51a36d76a2933bd3011c9 410 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 72 185 1.1E-30 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS13940 060a39d2c4b51a36d76a2933bd3011c9 410 Pfam PF13437 HlyD family secretion protein 231 313 8.8E-11 T 21-04-2016 SPH21_RS13940 060a39d2c4b51a36d76a2933bd3011c9 410 PANTHER PTHR30097 72 409 6.7E-24 T 21-04-2016 SPH21_RS13940 060a39d2c4b51a36d76a2933bd3011c9 410 Gene3D G3DSA:2.40.50.100 86 119 8.0E-7 T 21-04-2016 SPH21_RS13940 060a39d2c4b51a36d76a2933bd3011c9 410 Gene3D G3DSA:2.40.50.100 170 187 8.0E-7 T 21-04-2016 SPH21_RS16010 6297705512b31c5dcac725a0265cea27 399 Gene3D G3DSA:3.40.640.10 48 274 7.0E-66 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS16010 6297705512b31c5dcac725a0265cea27 399 PANTHER PTHR11751:SF404 11 394 2.6E-150 T 21-04-2016 SPH21_RS16010 6297705512b31c5dcac725a0265cea27 399 PANTHER PTHR11751 11 394 2.6E-150 T 21-04-2016 SPH21_RS16010 6297705512b31c5dcac725a0265cea27 399 SUPERFAMILY SSF53383 1 393 2.89E-97 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS16010 6297705512b31c5dcac725a0265cea27 399 Pfam PF00155 Aminotransferase class I and II 32 346 6.3E-49 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS16010 6297705512b31c5dcac725a0265cea27 399 Gene3D G3DSA:3.90.1150.10 275 394 1.7E-29 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 Gene3D G3DSA:1.20.140.10 300 450 3.9E-44 T 21-04-2016 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 Gene3D G3DSA:1.10.540.10 76 190 2.0E-32 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 79 186 6.7E-24 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 SUPERFAMILY SSF56645 69 297 2.62E-60 T 21-04-2016 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 404 423 - T 21-04-2016 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 SUPERFAMILY SSF47203 300 450 2.74E-42 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 193 286 1.8E-20 T 21-04-2016 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 PANTHER PTHR10909:SF280 8 452 1.2E-194 T 21-04-2016 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 Gene3D G3DSA:2.40.110.10 192 295 1.7E-25 T 21-04-2016 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 PANTHER PTHR10909 8 452 1.2E-194 T 21-04-2016 SPH21_RS14930 b1d6957195349a0c6cdfd39de6588fda 452 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 304 445 1.1E-35 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS19755 dfb04dc66dcd72bc1e1e39a44545c860 155 PANTHER PTHR11205 8 155 1.4E-79 T 21-04-2016 IPR000235 Ribosomal protein S5/S7 GO:0006412 SPH21_RS19755 dfb04dc66dcd72bc1e1e39a44545c860 155 Gene3D G3DSA:1.10.455.10 8 155 2.9E-61 T 21-04-2016 IPR023798 Ribosomal protein S7 domain SPH21_RS19755 dfb04dc66dcd72bc1e1e39a44545c860 155 Pfam PF00177 Ribosomal protein S7p/S5e 2 148 1.2E-62 T 21-04-2016 IPR023798 Ribosomal protein S7 domain SPH21_RS19755 dfb04dc66dcd72bc1e1e39a44545c860 155 TIGRFAM TIGR01029 rpsG_bact: ribosomal protein uS7 2 154 6.6E-64 T 21-04-2016 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 SPH21_RS19755 dfb04dc66dcd72bc1e1e39a44545c860 155 Hamap MF_00480_B 30S ribosomal protein S7 [rpsG]. 1 155 33.965 T 21-04-2016 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 SPH21_RS19755 dfb04dc66dcd72bc1e1e39a44545c860 155 SUPERFAMILY SSF47973 7 148 1.83E-58 T 21-04-2016 IPR023798 Ribosomal protein S7 domain SPH21_RS19755 dfb04dc66dcd72bc1e1e39a44545c860 155 PIRSF PIRSF002122 2 155 1.3E-53 T 21-04-2016 IPR000235 Ribosomal protein S5/S7 GO:0006412 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 ProDom PD004527 LYASE II 3-DEHYDROQUINATE BIOSYNTHESIS DEHYDRATASE TYPE 3-DEHYDROQUINASE DHQASE AMINO AROMATIC 3 137 2.0E-48 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 SUPERFAMILY SSF52304 1 136 1.1E-55 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 Gene3D G3DSA:3.40.50.9100 1 136 3.0E-58 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 Pfam PF01220 Dehydroquinase class II 2 136 2.6E-56 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 Hamap MF_00169 3-dehydroquinate dehydratase [aroQ]. 1 138 58.862 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 PIRSF PIRSF001399 1 138 2.0E-55 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 TIGRFAM TIGR01088 aroQ: 3-dehydroquinate dehydratase, type II 2 135 1.6E-54 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 ProSitePatterns PS01029 Dehydroquinase class II signature. 6 23 - T 21-04-2016 IPR018509 Dehydroquinase, class II, conserved site GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS15730 071f5e0c59bff1ccac7830e424f62bd2 138 PANTHER PTHR21272 1 134 7.2E-74 T 21-04-2016 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707|UniPathway: UPA00053 SPH21_RS04570 f2ebf511adc2f1b58b5ec1059a6f2499 393 Pfam PF04041 beta-1,4-mannooligosaccharide phosphorylase 72 362 1.4E-21 T 21-04-2016 IPR007184 Mannoside phosphorylase SPH21_RS04570 f2ebf511adc2f1b58b5ec1059a6f2499 393 PANTHER PTHR34106 1 368 2.1E-168 T 21-04-2016 SPH21_RS04570 f2ebf511adc2f1b58b5ec1059a6f2499 393 Hamap MF_00928 4-O-beta-D-mannosyl-D-glucose phosphorylase. 4 389 71.767 T 21-04-2016 IPR028583 4-O-beta-D-mannosyl-D-glucose phosphorylase MetaCyc: PWY-7456 SPH21_RS04570 f2ebf511adc2f1b58b5ec1059a6f2499 393 PANTHER PTHR34106:SF1 1 368 2.1E-168 T 21-04-2016 SPH21_RS04570 f2ebf511adc2f1b58b5ec1059a6f2499 393 PIRSF PIRSF016202 20 366 1.8E-100 T 21-04-2016 IPR007184 Mannoside phosphorylase SPH21_RS04570 f2ebf511adc2f1b58b5ec1059a6f2499 393 SUPERFAMILY SSF75005 48 371 9.54E-85 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS04570 f2ebf511adc2f1b58b5ec1059a6f2499 393 Gene3D G3DSA:2.115.10.20 17 365 8.6E-96 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS07845 2edad2e6b62d86fb0e3a12e67d9233d8 293 SUPERFAMILY SSF53850 27 283 5.16E-28 T 21-04-2016 SPH21_RS07845 2edad2e6b62d86fb0e3a12e67d9233d8 293 Pfam PF12849 PBP superfamily domain 27 264 3.0E-19 T 21-04-2016 IPR024370 PBP domain SPH21_RS07845 2edad2e6b62d86fb0e3a12e67d9233d8 293 PANTHER PTHR30570:SF1 32 281 2.6E-16 T 21-04-2016 SPH21_RS07845 2edad2e6b62d86fb0e3a12e67d9233d8 293 PANTHER PTHR30570 32 281 2.6E-16 T 21-04-2016 SPH21_RS07845 2edad2e6b62d86fb0e3a12e67d9233d8 293 Gene3D G3DSA:3.40.190.10 106 244 3.2E-14 T 21-04-2016 SPH21_RS04850 dca7c7237de313776fcdb63a9dcae4d5 332 SUPERFAMILY SSF54506 2 329 4.94E-109 T 21-04-2016 SPH21_RS04850 dca7c7237de313776fcdb63a9dcae4d5 332 PIRSF PIRSF029792 1 332 4.1E-124 T 21-04-2016 IPR008794 Proline racemase family SPH21_RS04850 dca7c7237de313776fcdb63a9dcae4d5 332 Pfam PF05544 Proline racemase 7 330 1.7E-125 T 21-04-2016 IPR008794 Proline racemase family SPH21_RS04850 dca7c7237de313776fcdb63a9dcae4d5 332 PANTHER PTHR33442 1 332 6.6E-129 T 21-04-2016 SPH21_RS04850 dca7c7237de313776fcdb63a9dcae4d5 332 Gene3D G3DSA:3.10.310.10 153 319 3.1E-63 T 21-04-2016 SPH21_RS04850 dca7c7237de313776fcdb63a9dcae4d5 332 PANTHER PTHR33442:SF2 1 332 6.6E-129 T 21-04-2016 SPH21_RS04850 dca7c7237de313776fcdb63a9dcae4d5 332 Gene3D G3DSA:3.10.310.10 1 152 4.8E-64 T 21-04-2016 SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 PRINTS PR00050 Cold shock protein signature 36 54 1.3E-7 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 PRINTS PR00050 Cold shock protein signature 4 19 1.3E-7 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 Pfam PF00313 'Cold-shock' DNA-binding domain 3 62 1.5E-17 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 PIRSF PIRSF002599 1 63 2.6E-15 T 21-04-2016 IPR012156 Cold shock, CspA GO:0003676 SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 SUPERFAMILY SSF50249 1 62 1.9E-19 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 Gene3D G3DSA:2.40.50.140 1 62 3.5E-22 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 21-04-2016 IPR019844 Cold-shock conserved site SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 SMART SM00357 3 63 2.1E-17 T 21-04-2016 IPR011129 Cold shock protein GO:0003676 SPH21_RS03810 f640f972b5433fb1c9bed749a18ea34b 63 PANTHER PTHR11544 1 63 3.0E-14 T 21-04-2016 SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PANTHER PTHR24322 148 181 7.4E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PANTHER PTHR24322 7 132 7.4E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 Pfam PF00106 short chain dehydrogenase 3 186 2.5E-47 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 135 163 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 SUPERFAMILY SSF51735 3 235 7.05E-62 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 122 138 1.4E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 1.4E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 1.4E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 1.4E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 1.4E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 128 136 4.5E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 4.5E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 4.5E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24565 7f836c105ef6ebc61a89afe68c0f3539 273 Gene3D G3DSA:3.40.50.720 3 249 3.2E-62 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 Gene3D G3DSA:1.10.10.10 107 169 1.6E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 12 168 2.6E-24 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 PANTHER PTHR30173 10 169 6.8E-34 T 21-04-2016 SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 Pfam PF08281 Sigma-70, region 4 115 162 3.9E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 SUPERFAMILY SSF88946 5 90 3.1E-13 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 Gene3D G3DSA:1.10.1740.10 8 88 7.5E-12 T 21-04-2016 SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 9 169 3.2E-39 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 Pfam PF04542 Sigma-70 region 2 13 77 1.5E-8 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23960 8bc3119ebc212afb5f8a1213a1403d7e 182 SUPERFAMILY SSF88659 103 169 2.83E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938 744 783 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938 821 885 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938 946 988 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938 912 930 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Pfam PF01568 Molydopterin dinucleotide binding domain 580 663 9.5E-6 T 21-04-2016 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Gene3D G3DSA:3.30.70.20 838 886 2.5E-15 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Gene3D G3DSA:3.30.70.20 747 837 1.1E-39 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Gene3D G3DSA:3.30.70.20 916 998 1.1E-39 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 SUPERFAMILY SSF54862 748 885 1.88E-47 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 SUPERFAMILY SSF54862 915 998 1.88E-47 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 SUPERFAMILY SSF53706 102 490 1.09E-27 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 TIGRFAM TIGR04519 MoCo_extend_TAT: MoCo/4Fe-4S cofactor protein extended Tat translocation domain 5 54 1.1E-16 T 21-04-2016 IPR030948 MoCo/4Fe-4S cofactor protein extended Tat translocation domain SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938:SF86 744 783 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938:SF86 821 885 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938:SF86 946 988 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 PANTHER PTHR11938:SF86 912 930 5.5E-37 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 SUPERFAMILY SSF50692 581 660 1.54E-9 T 21-04-2016 IPR009010 Aspartate decarboxylase-like domain SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Gene3D G3DSA:3.40.50.740 233 254 2.0E-12 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Gene3D G3DSA:3.40.50.740 388 497 2.0E-12 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Gene3D G3DSA:2.40.40.20 580 696 1.3E-10 T 21-04-2016 SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Pfam PF12838 4Fe-4S dicluster domain 865 960 8.4E-8 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS07665 46b2386e393d7519c6f18b33d428c5df 1007 Pfam PF12838 4Fe-4S dicluster domain 757 848 1.0E-8 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS17110 bf12741459a3e7a292ad63c122f72828 420 Gene3D G3DSA:3.40.720.10 13 327 3.1E-75 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS17110 bf12741459a3e7a292ad63c122f72828 420 PANTHER PTHR10151 4 403 9.6E-123 T 21-04-2016 IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family SPH21_RS17110 bf12741459a3e7a292ad63c122f72828 420 SUPERFAMILY SSF53649 41 401 2.13E-89 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS17110 bf12741459a3e7a292ad63c122f72828 420 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 47 360 4.6E-71 T 21-04-2016 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 19 176 6.4E-25 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 SUPERFAMILY SSF88946 9 103 2.31E-18 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 Pfam PF04542 Sigma-70 region 2 23 88 5.3E-11 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 PANTHER PTHR30173:SF20 8 184 7.1E-39 T 21-04-2016 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 SUPERFAMILY SSF88659 110 177 1.68E-11 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 Gene3D G3DSA:1.10.1740.10 9 99 1.2E-18 T 21-04-2016 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 Gene3D G3DSA:1.10.10.10 114 178 1.2E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 Pfam PF08281 Sigma-70, region 4 119 171 1.2E-9 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04605 44849956245d2d5cd6db716eff2f03df 190 PANTHER PTHR30173 8 184 7.1E-39 T 21-04-2016 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 SMART SM00924 31 133 4.8E-21 T 21-04-2016 IPR006668 Magnesium transporter, MgtE intracellular domain SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 Pfam PF03448 MgtE intracellular N domain 50 131 3.2E-17 T 21-04-2016 IPR006668 Magnesium transporter, MgtE intracellular domain SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 SUPERFAMILY SSF54631 132 272 8.09E-30 T 21-04-2016 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 Gene3D G3DSA:3.10.580.10 128 259 1.4E-19 T 21-04-2016 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 Pfam PF00571 CBS domain 133 179 2.4E-5 T 21-04-2016 IPR000644 CBS domain SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 Pfam PF00571 CBS domain 197 248 1.4E-7 T 21-04-2016 IPR000644 CBS domain SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 SUPERFAMILY SSF158791 6 130 9.02E-21 T 21-04-2016 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 Pfam PF01769 Divalent cation transporter 319 448 3.3E-29 T 21-04-2016 IPR006667 SLC41 divalent cation transporters, integral membrane domain GO:0006812|GO:0008324 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 Gene3D G3DSA:1.10.357.20 276 454 3.4E-58 T 21-04-2016 IPR006667 SLC41 divalent cation transporters, integral membrane domain GO:0006812|GO:0008324 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 SUPERFAMILY SSF161093 276 454 2.75E-48 T 21-04-2016 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 PANTHER PTHR11911:SF23 104 416 5.5E-41 T 21-04-2016 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 Gene3D G3DSA:1.25.60.10 5 127 4.9E-19 T 21-04-2016 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 TIGRFAM TIGR00400 mgtE: magnesium transporter 5 455 1.7E-110 T 21-04-2016 IPR006669 Magnesium transporter MgtE GO:0015095|GO:0015693|GO:0016020 SPH21_RS19705 bee5aea934ec99e2c7fc41aae58d6a2b 459 PANTHER PTHR11911 104 416 5.5E-41 T 21-04-2016 SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 PANTHER PTHR30237 40 347 1.4E-103 T 21-04-2016 SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 SUPERFAMILY SSF141986 206 343 5.75E-42 T 21-04-2016 IPR027461 LD-carboxypeptidase A, C-terminal domain SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 Gene3D G3DSA:3.50.30.60 210 344 3.7E-45 T 21-04-2016 IPR027461 LD-carboxypeptidase A, C-terminal domain SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 Pfam PF02016 LD-carboxypeptidase 51 336 3.0E-81 T 21-04-2016 IPR003507 Peptidase family S66 SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 SUPERFAMILY SSF52317 39 193 7.32E-49 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 PANTHER PTHR30237:SF2 40 347 1.4E-103 T 21-04-2016 SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 Gene3D G3DSA:3.40.50.10740 38 190 2.1E-52 T 21-04-2016 IPR027478 Murein tetrapeptide carboxypeptidase, N-terminal domain SPH21_RS19300 443a91cebe9bb4a1ad36c0e6aabd8ccb 352 PIRSF PIRSF028757 39 351 4.0E-85 T 21-04-2016 IPR003507 Peptidase family S66 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82693 38 129 2.09E-18 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 364 385 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 557 574 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 472 495 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 337 360 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 447 470 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 8 32 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 36 54 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 392 416 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PRINTS PR00702 Acriflavin resistance protein family signature 626 640 2.4E-88 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 Gene3D G3DSA:1.10.3850.10 815 1029 6.2E-54 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82693 810 859 5.06E-22 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82693 673 723 5.06E-22 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82866 297 499 1.26E-46 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82693 275 331 4.19E-20 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82693 135 182 4.19E-20 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 Gene3D G3DSA:3.30.2090.10 182 274 1.3E-20 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82693 570 672 3.92E-22 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PANTHER PTHR32063 1 1050 0.0 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 Gene3D G3DSA:3.30.2090.10 724 809 3.9E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82714 724 808 5.36E-13 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82866 833 1029 1.01E-42 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 Pfam PF00873 AcrB/AcrD/AcrF family 1 1028 2.5E-295 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 PANTHER PTHR32063:SF9 1 1050 0.0 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 Gene3D G3DSA:1.20.1640.10 293 506 3.9E-58 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family 1 1031 0.0 T 21-04-2016 IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 GO:0005215|GO:0006810|GO:0016021 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 Gene3D G3DSA:3.30.70.1430 572 672 1.3E-23 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 Gene3D G3DSA:3.30.70.1430 38 140 2.1E-22 T 21-04-2016 SPH21_RS07335 b775f9a2147e7c03d620ef6bfd2ac565 1064 SUPERFAMILY SSF82714 183 273 2.09E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS06360 1747ad8f62c952ab6b25a685eb245cef 144 PANTHER PTHR22881 11 140 2.9E-12 T 21-04-2016 SPH21_RS06360 1747ad8f62c952ab6b25a685eb245cef 144 TIGRFAM TIGR00043 TIGR00043: rRNA maturation RNase YbeY 40 140 2.8E-28 T 21-04-2016 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 SPH21_RS06360 1747ad8f62c952ab6b25a685eb245cef 144 Hamap MF_00009 Endoribonuclease YbeY [ybeY]. 12 142 16.818 T 21-04-2016 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 SPH21_RS06360 1747ad8f62c952ab6b25a685eb245cef 144 PANTHER PTHR22881:SF18 11 140 2.9E-12 T 21-04-2016 SPH21_RS06360 1747ad8f62c952ab6b25a685eb245cef 144 SUPERFAMILY SSF55486 4 141 2.27E-35 T 21-04-2016 SPH21_RS06360 1747ad8f62c952ab6b25a685eb245cef 144 Gene3D G3DSA:3.40.390.30 10 140 8.2E-34 T 21-04-2016 IPR023091 Metalloprotease catalytic domain, predicted GO:0004222 SPH21_RS06360 1747ad8f62c952ab6b25a685eb245cef 144 Pfam PF02130 Uncharacterized protein family UPF0054 16 140 1.3E-29 T 21-04-2016 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 SPH21_RS05430 26daad7581d0f0ea2d34b34ef18ee578 475 Pfam PF12771 Starch-binding associating with outer membrane 1 472 5.4E-43 T 21-04-2016 SPH21_RS05430 26daad7581d0f0ea2d34b34ef18ee578 475 SUPERFAMILY SSF48452 17 475 3.29E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05430 26daad7581d0f0ea2d34b34ef18ee578 475 PANTHER PTHR35148 1 475 1.2E-36 T 21-04-2016 SPH21_RS08090 178b0f926f1dcbee13f13f4ceac40c12 274 Pfam PF08323 Starch synthase catalytic domain 5 230 1.0E-50 T 21-04-2016 IPR013534 Starch synthase, catalytic domain KEGG: 00500+2.4.1.21|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS08090 178b0f926f1dcbee13f13f4ceac40c12 274 PANTHER PTHR12526:SF342 6 96 2.1E-19 T 21-04-2016 SPH21_RS08090 178b0f926f1dcbee13f13f4ceac40c12 274 PANTHER PTHR12526:SF342 116 162 2.1E-19 T 21-04-2016 SPH21_RS08090 178b0f926f1dcbee13f13f4ceac40c12 274 SUPERFAMILY SSF53756 5 181 2.93E-20 T 21-04-2016 SPH21_RS08090 178b0f926f1dcbee13f13f4ceac40c12 274 PANTHER PTHR12526 6 96 2.1E-19 T 21-04-2016 SPH21_RS08090 178b0f926f1dcbee13f13f4ceac40c12 274 PANTHER PTHR12526 116 162 2.1E-19 T 21-04-2016 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 PANTHER PTHR11695 16 343 1.1E-156 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 SUPERFAMILY SSF50129 11 173 1.73E-45 T 21-04-2016 IPR011032 GroES-like SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 PANTHER PTHR11695:SF582 16 343 1.1E-156 T 21-04-2016 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 62 76 - T 21-04-2016 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 SMART SM00829 11 340 3.9E-5 T 21-04-2016 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 141 2.5E-25 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 Pfam PF00107 Zinc-binding dehydrogenase 184 306 1.6E-19 T 21-04-2016 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 177 204 - T 21-04-2016 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 Gene3D G3DSA:3.40.50.720 177 290 1.7E-20 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 Gene3D G3DSA:3.90.180.10 2 176 4.8E-63 T 21-04-2016 IPR011032 GroES-like SPH21_RS23605 d49e1d76006b4ee395aa6472f85fad74 345 SUPERFAMILY SSF51735 147 310 7.91E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03415 c2eaf6633e2c138ac97686f63b3af652 434 Pfam PF04055 Radical SAM superfamily 97 267 7.2E-14 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS03415 c2eaf6633e2c138ac97686f63b3af652 434 Gene3D G3DSA:3.20.20.70 95 403 9.9E-43 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS03415 c2eaf6633e2c138ac97686f63b3af652 434 PANTHER PTHR11228 28 427 3.1E-48 T 21-04-2016 SPH21_RS03415 c2eaf6633e2c138ac97686f63b3af652 434 Pfam PF13353 4Fe-4S single cluster domain 102 216 1.6E-7 T 21-04-2016 SPH21_RS03415 c2eaf6633e2c138ac97686f63b3af652 434 PANTHER PTHR11228:SF5 28 427 3.1E-48 T 21-04-2016 SPH21_RS03415 c2eaf6633e2c138ac97686f63b3af652 434 TIGRFAM TIGR04085 rSAM_more_4Fe4S: radical SAM additional 4Fe4S-binding SPASM domain 326 404 1.1E-10 T 21-04-2016 IPR023885 4Fe4S-binding SPASM domain SPH21_RS03415 c2eaf6633e2c138ac97686f63b3af652 434 SUPERFAMILY SSF102114 94 397 1.83E-40 T 21-04-2016 SPH21_RS22710 98070c6145b71d3bf674d1b4407acce6 102 SUPERFAMILY SSF46955 41 91 5.74E-10 T 21-04-2016 IPR009061 Putative DNA-binding domain SPH21_RS22710 98070c6145b71d3bf674d1b4407acce6 102 PANTHER PTHR34585:SF15 2 101 6.0E-35 T 21-04-2016 SPH21_RS22710 98070c6145b71d3bf674d1b4407acce6 102 Pfam PF12728 Helix-turn-helix domain 42 89 2.1E-7 T 21-04-2016 SPH21_RS22710 98070c6145b71d3bf674d1b4407acce6 102 PANTHER PTHR34585 2 101 6.0E-35 T 21-04-2016 SPH21_RS22710 98070c6145b71d3bf674d1b4407acce6 102 Gene3D G3DSA:1.10.10.10 41 89 8.6E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS26140 ca5c4bceeb6da1c6db303b23188f0c22 510 PANTHER PTHR30008 3 381 4.9E-79 T 21-04-2016 SPH21_RS26140 ca5c4bceeb6da1c6db303b23188f0c22 510 PANTHER PTHR30008 425 502 4.9E-79 T 21-04-2016 SPH21_RS26140 ca5c4bceeb6da1c6db303b23188f0c22 510 Pfam PF13742 OB-fold nucleic acid binding domain 11 117 4.6E-14 T 21-04-2016 IPR025824 OB-fold nucleic acid binding domain GO:0003676 SPH21_RS26140 ca5c4bceeb6da1c6db303b23188f0c22 510 Pfam PF02601 Exonuclease VII, large subunit 142 500 1.7E-68 T 21-04-2016 IPR020579 Exonuclease VII, large subunit, C-terminal GO:0008855 SPH21_RS26140 ca5c4bceeb6da1c6db303b23188f0c22 510 PANTHER PTHR30008:SF0 3 381 4.9E-79 T 21-04-2016 SPH21_RS26140 ca5c4bceeb6da1c6db303b23188f0c22 510 PANTHER PTHR30008:SF0 425 502 4.9E-79 T 21-04-2016 SPH21_RS26140 ca5c4bceeb6da1c6db303b23188f0c22 510 TIGRFAM TIGR00237 xseA: exodeoxyribonuclease VII, large subunit 12 381 6.6E-75 T 21-04-2016 IPR003753 Exonuclease VII, large subunit GO:0006308|GO:0008855|GO:0009318 SPH21_RS21130 3e8ae6964a3b11912c4761549904e20c 121 PANTHER PTHR38482 1 120 5.9E-37 T 21-04-2016 SPH21_RS21130 3e8ae6964a3b11912c4761549904e20c 121 PIRSF PIRSF021239 1 121 1.9E-42 T 21-04-2016 IPR007437 Putative member of DMT superfamily SPH21_RS21130 3e8ae6964a3b11912c4761549904e20c 121 Pfam PF04342 Putative member of DMT superfamily (DUF486) 6 119 3.6E-42 T 21-04-2016 IPR007437 Putative member of DMT superfamily SPH21_RS08900 46c0e6e43020d37b389f7eb2ecffdfe8 361 Gene3D G3DSA:3.40.50.2000 165 310 4.8E-5 T 21-04-2016 SPH21_RS08900 46c0e6e43020d37b389f7eb2ecffdfe8 361 SUPERFAMILY SSF53756 19 355 2.09E-31 T 21-04-2016 SPH21_RS08900 46c0e6e43020d37b389f7eb2ecffdfe8 361 PANTHER PTHR12526 114 355 3.5E-12 T 21-04-2016 SPH21_RS08900 46c0e6e43020d37b389f7eb2ecffdfe8 361 Pfam PF00534 Glycosyl transferases group 1 165 250 1.9E-6 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 Pfam PF05116 Sucrose-6F-phosphate phosphohydrolase 2 229 3.3E-45 T 21-04-2016 IPR006380 Sucrose-phosphatase, N-terminal SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 PANTHER PTHR10788:SF35 476 744 6.6E-183 T 21-04-2016 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 PANTHER PTHR10788:SF35 248 460 6.6E-183 T 21-04-2016 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 SUPERFAMILY SSF56784 2 202 9.3E-29 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 TIGRFAM TIGR02398 gluc_glyc_Psyn: glucosylglycerol-phosphate synthase 258 742 3.1E-177 T 21-04-2016 IPR012764 Glucosylglycerol-phosphate synthase GO:0016758|GO:0051473 KEGG: 00500+2.4.1.21|MetaCyc: PWY-622|UniPathway: UPA00795 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 Gene3D G3DSA:3.40.50.1000 146 231 6.9E-29 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 Gene3D G3DSA:3.40.50.1000 2 78 6.9E-29 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 PANTHER PTHR10788 476 744 6.6E-183 T 21-04-2016 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 PANTHER PTHR10788 248 460 6.6E-183 T 21-04-2016 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 Gene3D G3DSA:3.40.50.2000 253 525 2.3E-63 T 21-04-2016 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 SUPERFAMILY SSF53756 254 743 1.19E-118 T 21-04-2016 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 TIGRFAM TIGR01484 HAD-SF-IIB: HAD hydrolase, family IIB 2 196 4.1E-16 T 21-04-2016 IPR006379 HAD-superfamily hydrolase, subfamily IIB Reactome: REACT_17015 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 Gene3D G3DSA:3.40.50.2000 526 726 1.9E-63 T 21-04-2016 SPH21_RS12895 09c5b81410a13569bf664f557235736c 744 Pfam PF00982 Glycosyltransferase family 20 254 742 1.2E-131 T 21-04-2016 IPR001830 Glycosyl transferase, family 20 GO:0003824|GO:0005992 SPH21_RS25765 be2e5857e44b9d8c705812ec1e4e44f4 164 PANTHER PTHR33445 1 161 1.2E-36 T 21-04-2016 SPH21_RS25765 be2e5857e44b9d8c705812ec1e4e44f4 164 Pfam PF00430 ATP synthase B/B' CF(0) 11 141 1.9E-30 T 21-04-2016 IPR002146 ATPase, F0 complex, subunit B/B', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 SPH21_RS25765 be2e5857e44b9d8c705812ec1e4e44f4 164 Gene3D G3DSA:1.20.5.620 66 124 2.2E-11 T 21-04-2016 IPR028987 F-type ATP synthase subunit B-like, membrane domain SPH21_RS25765 be2e5857e44b9d8c705812ec1e4e44f4 164 Hamap MF_01398 ATP synthase subunit b [atpF]. 3 163 12.976 T 21-04-2016 IPR002146 ATPase, F0 complex, subunit B/B', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 SPH21_RS25765 be2e5857e44b9d8c705812ec1e4e44f4 164 SUPERFAMILY SSF81573 66 125 8.11E-10 T 21-04-2016 IPR028987 F-type ATP synthase subunit B-like, membrane domain SPH21_RS25765 be2e5857e44b9d8c705812ec1e4e44f4 164 TIGRFAM TIGR01144 ATP_synt_b: ATP synthase F0, B subunit 15 161 1.7E-33 T 21-04-2016 IPR005864 ATPase, F0 complex, subunit B, bacterial GO:0015078|GO:0015986|GO:0045263 SPH21_RS06715 e652fa022e937bd1ce6fa072e4f5b9a7 92 PANTHER PTHR11178 4 75 4.5E-20 T 21-04-2016 SPH21_RS06715 e652fa022e937bd1ce6fa072e4f5b9a7 92 SUPERFAMILY SSF117916 2 75 9.16E-21 T 21-04-2016 SPH21_RS06715 e652fa022e937bd1ce6fa072e4f5b9a7 92 ProDom PD002830 NIFU NIFU NITROGEN-FIXING C-TERMINAL FIXATION NITROGEN NIFU-LIKE DOMAIN CLUSTER HESB/YADR/YFHF:NITROGEN-FIXING 11 75 6.0E-16 T 21-04-2016 IPR001075 NIF system FeS cluster assembly, NifU, C-terminal GO:0005506|GO:0016226|GO:0051536 SPH21_RS06715 e652fa022e937bd1ce6fa072e4f5b9a7 92 PANTHER PTHR11178:SF24 4 75 4.5E-20 T 21-04-2016 SPH21_RS06715 e652fa022e937bd1ce6fa072e4f5b9a7 92 Pfam PF01106 NifU-like domain 7 73 2.0E-22 T 21-04-2016 IPR001075 NIF system FeS cluster assembly, NifU, C-terminal GO:0005506|GO:0016226|GO:0051536 SPH21_RS07745 cd6e8a6881efbb7b460f8a7590b310de 269 SUPERFAMILY SSF57997 40 122 4.25E-5 T 21-04-2016 SPH21_RS07745 cd6e8a6881efbb7b460f8a7590b310de 269 PANTHER PTHR30329:SF4 12 263 4.9E-31 T 21-04-2016 SPH21_RS07745 cd6e8a6881efbb7b460f8a7590b310de 269 SUPERFAMILY SSF103088 136 257 1.44E-28 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS07745 cd6e8a6881efbb7b460f8a7590b310de 269 Gene3D G3DSA:3.30.1330.60 131 257 4.3E-31 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS07745 cd6e8a6881efbb7b460f8a7590b310de 269 Pfam PF00691 OmpA family 150 251 1.4E-20 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS07745 cd6e8a6881efbb7b460f8a7590b310de 269 PANTHER PTHR30329 12 263 4.9E-31 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 SUPERFAMILY SSF81653 308 401 9.81E-18 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Gene3D G3DSA:3.40.50.1000 481 512 2.5E-19 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Gene3D G3DSA:3.40.50.1000 606 754 2.5E-19 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Gene3D G3DSA:3.40.50.1000 544 545 2.5E-19 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 355 369 1.6E-11 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 632 642 1.6E-11 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 503 517 1.6E-11 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 686 705 1.6E-11 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PANTHER PTHR24093 100 795 4.4E-88 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00943 Copper-transporting ATPase signature 663 680 5.5E-9 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00943 Copper-transporting ATPase signature 486 501 5.5E-9 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00943 Copper-transporting ATPase signature 276 295 5.5E-9 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00943 Copper-transporting ATPase signature 136 156 5.5E-9 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PRINTS PR00943 Copper-transporting ATPase signature 427 441 5.5E-9 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Pfam PF00122 E1-E2 ATPase 279 494 3.0E-38 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Gene3D G3DSA:2.70.150.10 305 400 2.6E-16 T 21-04-2016 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 SUPERFAMILY SSF55008 88 157 1.28E-11 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 318 761 1.7E-45 T 21-04-2016 IPR001757 P-type ATPase GO:0016021 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Gene3D G3DSA:3.30.70.100 93 170 5.2E-7 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Pfam PF00702 haloacid dehalogenase-like hydrolase 499 700 1.0E-16 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 PANTHER PTHR24093:SF50 100 795 4.4E-88 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 Pfam PF12156 Putative metal-binding domain of cation transport ATPase 12 63 1.5E-9 T 21-04-2016 IPR021993 Putative metal-binding domain of cation transport ATPase SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 SUPERFAMILY SSF81665 406 497 3.79E-5 T 21-04-2016 SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 SUPERFAMILY SSF56784 501 521 5.77E-25 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS17540 11661a1b7a8971b1d6abf162f89c0e3d 798 SUPERFAMILY SSF56784 556 782 5.77E-25 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 Gene3D G3DSA:2.60.120.260 345 458 7.2E-24 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 SUPERFAMILY SSF49785 144 241 1.67E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 Pfam PF05592 Bacterial alpha-L-rhamnosidase 354 869 4.0E-193 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 Gene3D G3DSA:2.60.120.260 146 240 1.8E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 PANTHER PTHR33307 9 885 0.0 T 21-04-2016 SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 Gene3D G3DSA:2.60.40.10 56 138 1.6E-6 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 PIRSF PIRSF010631 9 908 0.0 T 21-04-2016 IPR016007 Alpha-L-rhamnosidase SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 178 345 2.5E-58 T 21-04-2016 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 PANTHER PTHR33307:SF5 9 885 0.0 T 21-04-2016 SPH21_RS02180 844d1a24ae5cdfe61b3ba0f50a13a9dd 917 SUPERFAMILY SSF48208 456 876 6.24E-54 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS14155 a4bb77f41fe8573740ea91ab0c3bfa3e 387 PANTHER PTHR33258:SF1 2 386 1.6E-162 T 21-04-2016 SPH21_RS14155 a4bb77f41fe8573740ea91ab0c3bfa3e 387 PANTHER PTHR33258 2 386 1.6E-162 T 21-04-2016 SPH21_RS14155 a4bb77f41fe8573740ea91ab0c3bfa3e 387 Gene3D G3DSA:3.90.350.10 254 308 6.1E-7 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS14155 a4bb77f41fe8573740ea91ab0c3bfa3e 387 SUPERFAMILY SSF53098 63 335 5.01E-36 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS14155 a4bb77f41fe8573740ea91ab0c3bfa3e 387 Pfam PF14294 Domain of unknown function (DUF4372) 4 75 1.5E-34 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS14155 a4bb77f41fe8573740ea91ab0c3bfa3e 387 Pfam PF01609 Transposase DDE domain 121 330 3.3E-35 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS17710 a4bb77f41fe8573740ea91ab0c3bfa3e 387 PANTHER PTHR33258:SF1 2 386 1.6E-162 T 21-04-2016 SPH21_RS17710 a4bb77f41fe8573740ea91ab0c3bfa3e 387 PANTHER PTHR33258 2 386 1.6E-162 T 21-04-2016 SPH21_RS17710 a4bb77f41fe8573740ea91ab0c3bfa3e 387 Gene3D G3DSA:3.90.350.10 254 308 6.1E-7 T 21-04-2016 IPR014736 Transposase, Tn5-like, core SPH21_RS17710 a4bb77f41fe8573740ea91ab0c3bfa3e 387 SUPERFAMILY SSF53098 63 335 5.01E-36 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS17710 a4bb77f41fe8573740ea91ab0c3bfa3e 387 Pfam PF14294 Domain of unknown function (DUF4372) 4 75 1.5E-34 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS17710 a4bb77f41fe8573740ea91ab0c3bfa3e 387 Pfam PF01609 Transposase DDE domain 121 330 3.3E-35 T 21-04-2016 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PANTHER PTHR24322 150 183 3.4E-53 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PANTHER PTHR24322 9 134 3.4E-53 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 SUPERFAMILY SSF51735 3 239 3.38E-65 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 2.14E-29 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 2.14E-29 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 6 23 2.14E-29 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 2.14E-29 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 2.14E-29 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 2.14E-29 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 1.96E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 1.96E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 1.96E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PANTHER PTHR24322:SF414 150 183 3.4E-53 T 21-04-2016 SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 PANTHER PTHR24322:SF414 9 134 3.4E-53 T 21-04-2016 SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 Gene3D G3DSA:3.40.50.720 4 252 1.5E-68 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23495 a7460f2a084d36ed369bc33793377eb4 277 Pfam PF00106 short chain dehydrogenase 5 190 1.0E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 SUPERFAMILY SSF56935 146 810 1.02E-72 T 21-04-2016 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 Gene3D G3DSA:2.170.130.10 164 255 5.8E-11 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 Pfam PF07715 TonB-dependent Receptor Plug Domain 165 254 1.9E-7 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 Pfam PF14905 Outer membrane protein beta-barrel family 401 808 4.0E-103 T 21-04-2016 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 Pfam PF13620 Carboxypeptidase regulatory-like domain 55 133 2.3E-13 T 21-04-2016 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 PANTHER PTHR32552:SF0 140 810 8.7E-15 T 21-04-2016 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 SUPERFAMILY SSF49464 53 147 1.7E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 PANTHER PTHR32552 140 810 8.7E-15 T 21-04-2016 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 Gene3D G3DSA:2.40.170.20 256 810 2.2E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02570 19979dc68e2fd1aff94635ee6b5bf6cb 842 Gene3D G3DSA:2.60.40.1120 55 153 8.9E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS08665 bbe5b946daa0586f104a71b41e65059d 302 SUPERFAMILY SSF53448 1 288 4.73E-23 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08665 bbe5b946daa0586f104a71b41e65059d 302 Pfam PF00483 Nucleotidyl transferase 28 245 2.2E-7 T 21-04-2016 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 Reactome: REACT_17015 SPH21_RS08665 bbe5b946daa0586f104a71b41e65059d 302 Gene3D G3DSA:3.90.550.10 5 280 3.3E-21 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS10530 32f87fbacab517df1061fcd7326ccf52 172 SUPERFAMILY SSF55729 10 154 1.76E-23 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS10530 32f87fbacab517df1061fcd7326ccf52 172 PANTHER PTHR13256 1 152 2.8E-16 T 21-04-2016 SPH21_RS10530 32f87fbacab517df1061fcd7326ccf52 172 Pfam PF13302 Acetyltransferase (GNAT) domain 17 153 3.4E-17 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS10530 32f87fbacab517df1061fcd7326ccf52 172 Gene3D G3DSA:3.40.630.30 3 153 2.8E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 SUPERFAMILY SSF56349 2 284 1.74E-47 T 21-04-2016 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 Hamap MF_01808 Tyrosine recombinase XerC [xerC]. 1 293 28.272 T 21-04-2016 IPR023009 Tyrosine recombinase XerC/XerD SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 Gene3D G3DSA:1.10.443.10 108 286 5.1E-42 T 21-04-2016 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 Gene3D G3DSA:1.10.150.130 2 93 2.7E-24 T 21-04-2016 IPR023109 Integrase/recombinase, N-terminal SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 Pfam PF02899 Phage integrase, N-terminal SAM-like domain 3 84 1.5E-17 T 21-04-2016 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 Pfam PF00589 Phage integrase family 107 278 9.8E-34 T 21-04-2016 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 PANTHER PTHR30349 2 291 4.4E-68 T 21-04-2016 SPH21_RS11835 4743d401f3ba01419eb3fbe2416467d8 293 PANTHER PTHR30349:SF5 2 291 4.4E-68 T 21-04-2016 SPH21_RS20100 591dca8927f09b184efbf5c1bf905574 123 PANTHER PTHR10584:SF191 5 64 6.5E-14 T 21-04-2016 SPH21_RS20100 591dca8927f09b184efbf5c1bf905574 123 Pfam PF04241 Protein of unknown function (DUF423) 17 106 1.1E-26 T 21-04-2016 IPR006696 Protein of unknown function DUF423 SPH21_RS20100 591dca8927f09b184efbf5c1bf905574 123 PANTHER PTHR10584 5 64 6.5E-14 T 21-04-2016 SPH21_RS05290 70e706c39ab9224e865576af56115947 302 SUPERFAMILY SSF74853 28 73 6.54E-5 T 21-04-2016 IPR001322 Lamin Tail Domain SPH21_RS05290 70e706c39ab9224e865576af56115947 302 Pfam PF00932 Lamin Tail Domain 28 142 1.8E-9 T 21-04-2016 IPR001322 Lamin Tail Domain SPH21_RS05290 70e706c39ab9224e865576af56115947 302 Pfam PF13585 C-terminal domain of CHU protein family 206 282 1.4E-6 T 21-04-2016 SPH21_RS21120 9eb3c15ba5c0ead93339dad9bcd34a96 531 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 34 442 4.0E-58 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS21120 9eb3c15ba5c0ead93339dad9bcd34a96 531 PANTHER PTHR11819:SF7 1 481 9.5E-81 T 21-04-2016 SPH21_RS21120 9eb3c15ba5c0ead93339dad9bcd34a96 531 Pfam PF00474 Sodium:solute symporter family 35 432 2.6E-32 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS21120 9eb3c15ba5c0ead93339dad9bcd34a96 531 PANTHER PTHR11819 1 481 9.5E-81 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS23940 b869d5b04e1dda6843c336e76be82177 122 Gene3D G3DSA:1.10.10.10 7 109 2.5E-32 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23940 b869d5b04e1dda6843c336e76be82177 122 Pfam PF01638 HxlR-like helix-turn-helix 20 108 3.4E-24 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS23940 b869d5b04e1dda6843c336e76be82177 122 PANTHER PTHR33204 1 108 2.5E-30 T 21-04-2016 SPH21_RS23940 b869d5b04e1dda6843c336e76be82177 122 SUPERFAMILY SSF46785 9 105 1.51E-25 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23940 b869d5b04e1dda6843c336e76be82177 122 PANTHER PTHR33204:SF8 1 108 2.5E-30 T 21-04-2016 SPH21_RS06730 811b91612795f6719a56c301d7072f3d 177 PANTHER PTHR22573 11 173 6.6E-52 T 21-04-2016 SPH21_RS06730 811b91612795f6719a56c301d7072f3d 177 Pfam PF00156 Phosphoribosyl transferase domain 24 163 2.8E-24 T 21-04-2016 IPR000836 Phosphoribosyltransferase domain GO:0009116 SPH21_RS06730 811b91612795f6719a56c301d7072f3d 177 PANTHER PTHR22573:SF56 11 173 6.6E-52 T 21-04-2016 SPH21_RS06730 811b91612795f6719a56c301d7072f3d 177 TIGRFAM TIGR01203 HGPRTase: hypoxanthine phosphoribosyltransferase 13 174 1.2E-48 T 21-04-2016 IPR005904 Hypoxanthine phosphoribosyl transferase GO:0004422|GO:0005737|GO:0006166 KEGG: 00230+2.4.2.8|KEGG: 00983+2.4.2.8|MetaCyc: PWY-6599|MetaCyc: PWY-6609|MetaCyc: PWY-6610|MetaCyc: PWY-6620|UniPathway: UPA00591 SPH21_RS06730 811b91612795f6719a56c301d7072f3d 177 SUPERFAMILY SSF53271 10 174 1.84E-41 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS06730 811b91612795f6719a56c301d7072f3d 177 Gene3D G3DSA:3.40.50.2020 2 174 5.6E-60 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS22640 11d5961070cbf0630d2d68b52b0fd26e 371 Gene3D G3DSA:2.120.10.80 26 316 5.3E-33 T 21-04-2016 IPR015915 Kelch-type beta propeller GO:0005515 SPH21_RS22640 11d5961070cbf0630d2d68b52b0fd26e 371 SUPERFAMILY SSF117281 79 367 8.11E-31 T 21-04-2016 SPH21_RS22640 11d5961070cbf0630d2d68b52b0fd26e 371 PANTHER PTHR23244 27 258 8.3E-12 T 21-04-2016 SPH21_RS23345 49407bc32ce2c08bc58082af0bb3553a 296 TIGRFAM TIGR02138 phosphate_pstC: phosphate ABC transporter, permease protein PstC 12 290 7.8E-84 T 21-04-2016 IPR011864 Phosphate ABC transporter, permease protein PstC GO:0005315|GO:0006817|GO:0016021 SPH21_RS23345 49407bc32ce2c08bc58082af0bb3553a 296 PANTHER PTHR30425 4 296 1.4E-107 T 21-04-2016 SPH21_RS23345 49407bc32ce2c08bc58082af0bb3553a 296 Gene3D G3DSA:1.10.3720.10 66 292 1.8E-45 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS23345 49407bc32ce2c08bc58082af0bb3553a 296 PANTHER PTHR30425:SF3 4 296 1.4E-107 T 21-04-2016 SPH21_RS23345 49407bc32ce2c08bc58082af0bb3553a 296 SUPERFAMILY SSF161098 31 282 5.36E-40 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS23345 49407bc32ce2c08bc58082af0bb3553a 296 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 87 291 1.6E-27 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 Pfam PF16363 GDP-mannose 4,6 dehydratase 5 352 1.1E-157 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 Gene3D G3DSA:3.90.25.10 192 246 9.7E-51 T 21-04-2016 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 Gene3D G3DSA:3.90.25.10 310 368 9.7E-51 T 21-04-2016 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 SUPERFAMILY SSF51735 2 357 2.67E-83 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 PANTHER PTHR10366 3 281 1.5E-208 T 21-04-2016 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 PANTHER PTHR10366 316 364 1.5E-208 T 21-04-2016 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 PANTHER PTHR10366:SF32 3 281 1.5E-208 T 21-04-2016 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 PANTHER PTHR10366:SF32 316 364 1.5E-208 T 21-04-2016 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 TIGRFAM TIGR01472 gmd: GDP-mannose 4,6-dehydratase 2 359 2.6E-178 T 21-04-2016 IPR006368 GDP-mannose 4,6-dehydratase GO:0008446|GO:0019673 KEGG: 00051+4.2.1.47|KEGG: 00520+4.2.1.47|MetaCyc: PWY-5738|MetaCyc: PWY-5739|MetaCyc: PWY-5740|MetaCyc: PWY-66|MetaCyc: PWY-7573|UniPathway: UPA00128 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 Hamap MF_00955 GDP-mannose 4,6-dehydratase [gmd]. 2 362 55.938 T 21-04-2016 IPR006368 GDP-mannose 4,6-dehydratase GO:0008446|GO:0019673 KEGG: 00051+4.2.1.47|KEGG: 00520+4.2.1.47|MetaCyc: PWY-5738|MetaCyc: PWY-5739|MetaCyc: PWY-5740|MetaCyc: PWY-66|MetaCyc: PWY-7573|UniPathway: UPA00128 SPH21_RS08685 185f393016b7225141d05d1e2505fe75 378 Gene3D G3DSA:3.40.50.720 1 189 3.8E-44 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 207 237 5.8E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Gene3D G3DSA:2.170.130.10 126 234 7.4E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532 14 309 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532 430 455 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532 547 1043 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532 335 393 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 SUPERFAMILY SSF49464 33 114 7.59E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 SUPERFAMILY SSF56935 349 417 5.04E-90 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 SUPERFAMILY SSF56935 960 1043 5.04E-90 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 SUPERFAMILY SSF56935 886 921 5.04E-90 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 SUPERFAMILY SSF56935 114 260 5.04E-90 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 SUPERFAMILY SSF56935 465 815 5.04E-90 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 34 1045 3.2E-265 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532:SF57 14 309 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532:SF57 430 455 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532:SF57 547 1043 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 PANTHER PTHR11532:SF57 335 393 1.3E-245 T 21-04-2016 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Gene3D G3DSA:2.60.40.1120 35 125 2.4E-17 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Pfam PF07715 TonB-dependent Receptor Plug Domain 126 231 1.8E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Gene3D G3DSA:2.40.170.20 348 431 3.7E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Gene3D G3DSA:2.40.170.20 235 255 3.7E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Gene3D G3DSA:2.40.170.20 951 1044 3.7E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Gene3D G3DSA:2.40.170.20 885 910 3.7E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Gene3D G3DSA:2.40.170.20 471 825 3.7E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08765 fec74392482b85fdedc62849be05567c 1045 Pfam PF13715 CarboxypepD_reg-like domain 35 116 1.0E-20 T 21-04-2016 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 Pfam PF00364 Biotin-requiring enzyme 8 77 1.5E-15 T 21-04-2016 IPR000089 Biotin/lipoyl attachment SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 PANTHER PTHR23151:SF8 196 443 2.3E-136 T 21-04-2016 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 PANTHER PTHR23151:SF8 8 176 2.3E-136 T 21-04-2016 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 SUPERFAMILY SSF52777 213 441 1.47E-80 T 21-04-2016 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 SUPERFAMILY SSF47005 131 174 1.57E-8 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 213 441 1.9E-77 T 21-04-2016 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 Pfam PF02817 e3 binding domain 133 170 7.3E-11 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 SUPERFAMILY SSF51230 3 89 3.14E-24 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 28 57 - T 21-04-2016 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 Gene3D G3DSA:4.10.320.10 131 179 2.5E-14 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 Gene3D G3DSA:2.40.50.100 5 90 3.8E-24 T 21-04-2016 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 Gene3D G3DSA:3.30.559.10 206 441 7.6E-82 T 21-04-2016 IPR023213 Chloramphenicol acetyltransferase-like domain SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 PANTHER PTHR23151 196 443 2.3E-136 T 21-04-2016 SPH21_RS12585 6096f52ec2d30c5191d28c581a0678c4 447 PANTHER PTHR23151 8 176 2.3E-136 T 21-04-2016 SPH21_RS02600 72f54aea3f0b28c7e90f83809e42d110 347 PANTHER PTHR10188:SF24 26 340 3.3E-136 T 21-04-2016 SPH21_RS02600 72f54aea3f0b28c7e90f83809e42d110 347 PANTHER PTHR10188 26 340 3.3E-136 T 21-04-2016 IPR000246 Peptidase T2, asparaginase 2 GO:0016787 SPH21_RS02600 72f54aea3f0b28c7e90f83809e42d110 347 SUPERFAMILY SSF56235 27 337 3.31E-99 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS02600 72f54aea3f0b28c7e90f83809e42d110 347 Pfam PF01112 Asparaginase 28 337 7.2E-125 T 21-04-2016 IPR000246 Peptidase T2, asparaginase 2 GO:0016787 SPH21_RS03100 db6f7339a66d6b4189639b1017f5818e 109 SUPERFAMILY SSF54909 1 109 2.63E-29 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS03100 db6f7339a66d6b4189639b1017f5818e 109 Pfam PF05336 Domain of unknown function (DUF718) 4 109 2.9E-30 T 21-04-2016 IPR008000 Rhamnose/fucose mutarotase GO:0005737|GO:0016857 UniPathway: UPA00125 SPH21_RS03100 db6f7339a66d6b4189639b1017f5818e 109 PANTHER PTHR34389:SF3 1 109 4.7E-33 T 21-04-2016 SPH21_RS03100 db6f7339a66d6b4189639b1017f5818e 109 PANTHER PTHR34389 1 109 4.7E-33 T 21-04-2016 SPH21_RS04635 00e427eaca45b7f4ded5c27f97a12afc 270 PANTHER PTHR11019 30 268 1.4E-17 T 21-04-2016 SPH21_RS04635 00e427eaca45b7f4ded5c27f97a12afc 270 SUPERFAMILY SSF46689 222 268 8.96E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04635 00e427eaca45b7f4ded5c27f97a12afc 270 SMART SM00342 186 269 1.5E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04635 00e427eaca45b7f4ded5c27f97a12afc 270 Gene3D G3DSA:1.10.10.60 177 222 1.5E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04635 00e427eaca45b7f4ded5c27f97a12afc 270 Pfam PF12833 Helix-turn-helix domain 194 268 1.7E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04635 00e427eaca45b7f4ded5c27f97a12afc 270 Gene3D G3DSA:1.10.10.60 223 268 5.1E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18600 a08233d56d016d4073e48ce31f1357ad 77 PANTHER PTHR33359 1 77 9.3E-12 T 21-04-2016 SPH21_RS18600 a08233d56d016d4073e48ce31f1357ad 77 SUPERFAMILY SSF54285 3 77 2.43E-10 T 21-04-2016 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp SPH21_RS18600 a08233d56d016d4073e48ce31f1357ad 77 PANTHER PTHR33359:SF1 1 77 9.3E-12 T 21-04-2016 SPH21_RS18600 a08233d56d016d4073e48ce31f1357ad 77 Gene3D G3DSA:3.10.20.30 1 77 9.2E-13 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS18600 a08233d56d016d4073e48ce31f1357ad 77 Pfam PF02597 ThiS family 5 77 1.5E-8 T 21-04-2016 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 Gene3D G3DSA:3.90.1150.10 253 354 1.8E-36 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 ProSitePatterns PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 182 201 - T 21-04-2016 IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 Gene3D G3DSA:3.40.640.10 15 251 2.4E-97 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 SUPERFAMILY SSF53383 2 353 1.05E-104 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 Hamap MF_00160 Phosphoserine aminotransferase [serC]. 1 354 46.015 T 21-04-2016 IPR022278 Phosphoserine aminotransferase GO:0004648|GO:0006564 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52|UniPathway: UPA00135|UniPathway: UPA00244 SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 PANTHER PTHR21152 3 354 1.9E-169 T 21-04-2016 SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 TIGRFAM TIGR01364 serC_1: phosphoserine transaminase 3 354 6.5E-147 T 21-04-2016 IPR022278 Phosphoserine aminotransferase GO:0004648|GO:0006564 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52|UniPathway: UPA00135|UniPathway: UPA00244 SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 PIRSF PIRSF000525 1 355 7.3E-139 T 21-04-2016 IPR022278 Phosphoserine aminotransferase GO:0004648|GO:0006564 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52|UniPathway: UPA00135|UniPathway: UPA00244 SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 Pfam PF00266 Aminotransferase class-V 4 341 9.2E-46 T 21-04-2016 IPR000192 Aminotransferase class V domain SPH21_RS15375 d57e8c4211ee0dc1e4432b7655350eb8 355 PANTHER PTHR21152:SF1 3 354 1.9E-169 T 21-04-2016 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 Gene3D G3DSA:3.20.20.70 4 333 2.3E-59 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 SUPERFAMILY SSF51412 4 76 4.43E-56 T 21-04-2016 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 SUPERFAMILY SSF51412 107 334 4.43E-56 T 21-04-2016 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 PANTHER PTHR32332 114 351 7.9E-94 T 21-04-2016 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 PANTHER PTHR32332 2 83 7.9E-94 T 21-04-2016 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 PANTHER PTHR32332:SF12 114 351 7.9E-94 T 21-04-2016 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 PANTHER PTHR32332:SF12 2 83 7.9E-94 T 21-04-2016 SPH21_RS04655 ea3b17bdc52bccc857442c0559866f7d 356 Pfam PF03060 Nitronate monooxygenase 5 349 1.2E-72 T 21-04-2016 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 9.0E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 125 133 9.0E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 145 164 9.0E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 SUPERFAMILY SSF51735 1 239 1.23E-56 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 119 135 3.8E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 183 3.8E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 3.8E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 164 3.8E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 3.8E-20 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 Gene3D G3DSA:3.40.50.720 2 241 8.2E-60 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PANTHER PTHR24322 145 176 2.8E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 PANTHER PTHR24322 7 129 2.8E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 Pfam PF00106 short chain dehydrogenase 3 185 1.8E-43 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20820 37df8bba467b147d58b6f531e646bc5a 267 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 132 160 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS15215 226bad693f410619deb45c01a426f678 255 Gene3D G3DSA:3.30.1330.30 9 85 1.8E-16 T 21-04-2016 IPR029064 50S ribosomal protein L30e-like SPH21_RS15215 226bad693f410619deb45c01a426f678 255 SUPERFAMILY SSF55315 7 85 6.77E-15 T 21-04-2016 IPR029064 50S ribosomal protein L30e-like SPH21_RS15215 226bad693f410619deb45c01a426f678 255 TIGRFAM TIGR00186 rRNA_methyl_3: RNA methyltransferase, TrmH family, group 3 14 252 5.1E-61 T 21-04-2016 IPR004441 RNA methyltransferase TrmH family GO:0006396|GO:0008173 SPH21_RS15215 226bad693f410619deb45c01a426f678 255 PANTHER PTHR12029 1 252 1.7E-76 T 21-04-2016 SPH21_RS15215 226bad693f410619deb45c01a426f678 255 SMART SM00967 15 89 2.6E-18 T 21-04-2016 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SPH21_RS15215 226bad693f410619deb45c01a426f678 255 Gene3D G3DSA:3.40.1280.10 101 253 7.2E-49 T 21-04-2016 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SPH21_RS15215 226bad693f410619deb45c01a426f678 255 Pfam PF08032 RNA 2'-O ribose methyltransferase substrate binding 16 88 1.6E-17 T 21-04-2016 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SPH21_RS15215 226bad693f410619deb45c01a426f678 255 Pfam PF00588 SpoU rRNA Methylase family 106 246 1.1E-39 T 21-04-2016 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 SPH21_RS15215 226bad693f410619deb45c01a426f678 255 SUPERFAMILY SSF75217 77 253 2.88E-46 T 21-04-2016 IPR029028 Alpha/beta knot methyltransferases SPH21_RS07945 969be6a1e5d49d8f39fc72b74b873fc0 280 PANTHER PTHR21363 1 279 2.8E-62 T 21-04-2016 SPH21_RS07945 969be6a1e5d49d8f39fc72b74b873fc0 280 PANTHER PTHR21363:SF0 1 279 2.8E-62 T 21-04-2016 SPH21_RS07945 969be6a1e5d49d8f39fc72b74b873fc0 280 SUPERFAMILY SSF51735 1 165 2.6E-40 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07945 969be6a1e5d49d8f39fc72b74b873fc0 280 Pfam PF02153 Prephenate dehydrogenase 15 270 2.6E-65 T 21-04-2016 IPR003099 Prephenate dehydrogenase GO:0004665|GO:0006571|GO:0008977|GO:0055114 KEGG: 00400+1.3.1.12|KEGG: 00401+1.3.1.12|MetaCyc: PWY-7303 SPH21_RS07945 969be6a1e5d49d8f39fc72b74b873fc0 280 Gene3D G3DSA:3.40.50.720 1 175 4.8E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07945 969be6a1e5d49d8f39fc72b74b873fc0 280 SUPERFAMILY SSF48179 170 275 4.08E-27 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS06225 1a8e787b57be48f64158d749b727d156 355 Pfam PF03403 Platelet-activating factor acetylhydrolase, isoform II 89 126 5.5E-5 T 21-04-2016 IPR005065 Platelet-activating factor acetylhydrolase GO:0003847|GO:0016042 KEGG: 00565+3.1.1.47 SPH21_RS06225 1a8e787b57be48f64158d749b727d156 355 Gene3D G3DSA:3.40.50.1820 237 355 2.3E-40 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06225 1a8e787b57be48f64158d749b727d156 355 Gene3D G3DSA:3.40.50.1820 35 187 2.3E-40 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06225 1a8e787b57be48f64158d749b727d156 355 SUPERFAMILY SSF53474 34 187 2.68E-29 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06225 1a8e787b57be48f64158d749b727d156 355 SUPERFAMILY SSF53474 237 352 2.68E-29 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS06225 1a8e787b57be48f64158d749b727d156 355 PIRSF PIRSF031982 11 355 7.7E-69 T 21-04-2016 IPR016986 Uncharacterised conserved protein UCP031982, alpha/beta hydrolase, XabL SPH21_RS22520 263e1c4a01099f6b263979c9eddde191 344 Pfam PF00296 Luciferase-like monooxygenase 22 302 3.7E-39 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS22520 263e1c4a01099f6b263979c9eddde191 344 TIGRFAM TIGR03858 LLM_2I7G: probable oxidoreductase, LLM family 2 339 2.2E-145 T 21-04-2016 IPR022290 Conserved hypothetical protein CHP03858, luciferase-like monooxygenase, putative SPH21_RS22520 263e1c4a01099f6b263979c9eddde191 344 SUPERFAMILY SSF51679 1 340 3.89E-69 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS22520 263e1c4a01099f6b263979c9eddde191 344 PANTHER PTHR30137:SF8 1 342 2.8E-116 T 21-04-2016 SPH21_RS22520 263e1c4a01099f6b263979c9eddde191 344 PANTHER PTHR30137 1 342 2.8E-116 T 21-04-2016 SPH21_RS22520 263e1c4a01099f6b263979c9eddde191 344 Gene3D G3DSA:3.20.20.30 1 341 9.2E-82 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 ProSitePatterns PS01086 Ribulose-phosphate 3-epimerase family signature 2. 134 156 - T 21-04-2016 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 ProSitePatterns PS01085 Ribulose-phosphate 3-epimerase family signature 1. 32 46 - T 21-04-2016 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 SUPERFAMILY SSF51366 2 214 9.42E-68 T 21-04-2016 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 Pfam PF00834 Ribulose-phosphate 3 epimerase family 5 201 6.5E-79 T 21-04-2016 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 TIGRFAM TIGR01163 rpe: ribulose-phosphate 3-epimerase 4 214 5.8E-85 T 21-04-2016 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 PIRSF PIRSF001461 1 222 5.7E-86 T 21-04-2016 IPR026019 Ribulose-phosphate 3-epimerase GO:0004750|GO:0006098 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 Gene3D G3DSA:3.20.20.70 2 215 1.4E-87 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15370 fcbde4a9a4cd3042d35ebebe5808ce98 223 PANTHER PTHR11749 1 216 3.0E-107 T 21-04-2016 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SPH21_RS24025 912e36cc24f1cd7eedfc327fe5d5e426 113 Gene3D G3DSA:3.30.70.1060 1 110 2.3E-18 T 21-04-2016 SPH21_RS24025 912e36cc24f1cd7eedfc327fe5d5e426 113 SUPERFAMILY SSF54909 6 109 5.36E-14 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS24025 912e36cc24f1cd7eedfc327fe5d5e426 113 Pfam PF03795 YCII-related domain 47 109 2.8E-9 T 21-04-2016 IPR005545 YCII-related SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 Pfam PF01926 50S ribosome-binding GTPase 5 121 3.1E-22 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 PIRSF PIRSF006641 1 366 1.5E-160 T 21-04-2016 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 TIGRFAM TIGR00092 TIGR00092: GTP-binding protein YchF 1 366 1.7E-152 T 21-04-2016 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 Gene3D G3DSA:1.10.150.300 131 201 2.0E-26 T 21-04-2016 IPR023192 TGS-like domain SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 Gene3D G3DSA:3.40.50.300 202 269 1.4E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 Gene3D G3DSA:3.40.50.300 4 130 1.4E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 SUPERFAMILY SSF81271 282 363 1.33E-37 T 21-04-2016 IPR012676 TGS-like KEGG: 00970+6.1.1.3 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 SUPERFAMILY SSF52540 3 304 1.19E-82 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 Pfam PF06071 Protein of unknown function (DUF933) 282 365 4.7E-42 T 21-04-2016 IPR013029 Domain of unknown function DUF933 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 Hamap MF_00944 Ribosome-binding ATPase YchF [ychF]. 2 366 44.094 T 21-04-2016 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 PANTHER PTHR23305 1 366 1.6E-201 T 21-04-2016 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 5 25 7.6E-35 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 87 105 7.6E-35 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 26 44 7.6E-35 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 70 85 7.6E-35 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS15580 c07d4a93f45561c2a936eb549973d5c1 366 Gene3D G3DSA:3.10.20.30 270 366 3.4E-51 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 Hamap MF_01023 Histidinol-phosphate aminotransferase [hisC]. 8 349 55.654 T 21-04-2016 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9|UniPathway: UPA00031 SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 Gene3D G3DSA:3.90.1150.10 250 347 3.4E-26 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 207 216 - T 21-04-2016 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 PANTHER PTHR11751 7 346 1.6E-127 T 21-04-2016 SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 SUPERFAMILY SSF53383 10 346 2.2E-75 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 Gene3D G3DSA:3.40.640.10 46 249 6.1E-77 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 PANTHER PTHR11751:SF424 7 346 1.6E-127 T 21-04-2016 SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 Pfam PF00155 Aminotransferase class I and II 48 345 4.8E-55 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS25315 3a888233fc8a6b350e3277a1c6d5e37c 354 TIGRFAM TIGR01141 hisC: histidinol-phosphate transaminase 10 347 5.3E-114 T 21-04-2016 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9|UniPathway: UPA00031 SPH21_RS25895 7e983e96c8dd83dfacb296280b7406e2 164 TIGRFAM TIGR00114 lumazine-synth: 6,7-dimethyl-8-ribityllumazine synthase 23 158 1.5E-47 T 21-04-2016 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS25895 7e983e96c8dd83dfacb296280b7406e2 164 Hamap MF_00178 6,7-dimethyl-8-ribityllumazine synthase [ribH]. 17 162 27.834 T 21-04-2016 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS25895 7e983e96c8dd83dfacb296280b7406e2 164 Gene3D G3DSA:3.40.50.960 18 163 3.3E-59 T 21-04-2016 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS25895 7e983e96c8dd83dfacb296280b7406e2 164 Pfam PF00885 6,7-dimethyl-8-ribityllumazine synthase 22 159 2.3E-53 T 21-04-2016 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS25895 7e983e96c8dd83dfacb296280b7406e2 164 SUPERFAMILY SSF52121 18 162 1.96E-53 T 21-04-2016 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS25895 7e983e96c8dd83dfacb296280b7406e2 164 PANTHER PTHR21058 19 164 1.7E-66 T 21-04-2016 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168|UniPathway: UPA00275 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 PANTHER PTHR23090 1 534 4.5E-124 T 21-04-2016 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 TIGRFAM TIGR00552 nadE: NAD+ synthetase 280 526 3.1E-64 T 21-04-2016 IPR003694 NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.1.5|UniPathway: UPA00253 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 Pfam PF00795 Carbon-nitrogen hydrolase 3 251 1.3E-21 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 PIRSF PIRSF006630 1 546 3.0E-172 T 21-04-2016 IPR014445 Glutamine-dependent NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.5.1|MetaCyc: PWY-5381|MetaCyc: PWY-5653|UniPathway: UPA00253 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 SUPERFAMILY SSF52402 272 530 7.64E-72 T 21-04-2016 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 SUPERFAMILY SSF56317 1 254 1.96E-50 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 Gene3D G3DSA:3.40.50.620 270 530 1.5E-71 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 Gene3D G3DSA:3.60.110.10 2 256 3.9E-52 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS25720 3541f4425e5414b22bcf5436ca192ccc 547 Pfam PF02540 NAD synthase 275 520 1.3E-73 T 21-04-2016 IPR022310 NAD/GMP synthase SPH21_RS21390 37515e77870ff90c7dada49dd8d7e398 296 PANTHER PTHR22911 1 289 4.5E-60 T 21-04-2016 SPH21_RS21390 37515e77870ff90c7dada49dd8d7e398 296 Pfam PF00892 EamA-like transporter family 141 279 6.4E-18 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS21390 37515e77870ff90c7dada49dd8d7e398 296 Pfam PF00892 EamA-like transporter family 3 133 6.8E-10 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS21390 37515e77870ff90c7dada49dd8d7e398 296 SUPERFAMILY SSF103481 181 282 1.44E-9 T 21-04-2016 SPH21_RS21390 37515e77870ff90c7dada49dd8d7e398 296 SUPERFAMILY SSF103481 35 136 3.79E-7 T 21-04-2016 SPH21_RS21390 37515e77870ff90c7dada49dd8d7e398 296 PANTHER PTHR22911:SF71 1 289 4.5E-60 T 21-04-2016 SPH21_RS25490 40796fded895fb4dd4af056920b2a02a 61 SUPERFAMILY SSF69047 1 59 9.81E-17 T 21-04-2016 IPR008462 CsbD-like SPH21_RS25490 40796fded895fb4dd4af056920b2a02a 61 Gene3D G3DSA:1.10.1470.10 1 60 9.5E-20 T 21-04-2016 IPR008462 CsbD-like SPH21_RS25490 40796fded895fb4dd4af056920b2a02a 61 Pfam PF05532 CsbD-like 5 54 1.2E-17 T 21-04-2016 IPR008462 CsbD-like SPH21_RS14210 9d6fee4aa55e1172e90de9244bfa1a32 145 SUPERFAMILY SSF49764 11 138 3.24E-36 T 21-04-2016 IPR008978 HSP20-like chaperone SPH21_RS14210 9d6fee4aa55e1172e90de9244bfa1a32 145 Gene3D G3DSA:2.60.40.790 5 144 1.7E-38 T 21-04-2016 IPR008978 HSP20-like chaperone SPH21_RS14210 9d6fee4aa55e1172e90de9244bfa1a32 145 PANTHER PTHR11527:SF122 13 144 2.1E-35 T 21-04-2016 SPH21_RS14210 9d6fee4aa55e1172e90de9244bfa1a32 145 Pfam PF00011 Hsp20/alpha crystallin family 42 144 4.3E-25 T 21-04-2016 IPR002068 Alpha crystallin/Hsp20 domain SPH21_RS14210 9d6fee4aa55e1172e90de9244bfa1a32 145 PANTHER PTHR11527 13 144 2.1E-35 T 21-04-2016 IPR031107 Small heat shock protein HSP20 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 SUPERFAMILY SSF53187 366 452 3.02E-64 T 21-04-2016 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 SUPERFAMILY SSF53187 3 195 3.02E-64 T 21-04-2016 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 Gene3D G3DSA:3.40.630.10 365 453 3.8E-65 T 21-04-2016 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 Gene3D G3DSA:3.40.630.10 3 189 3.8E-65 T 21-04-2016 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 Gene3D G3DSA:3.30.70.360 195 362 1.4E-63 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 Pfam PF07687 Peptidase dimerisation domain 192 352 1.8E-24 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 Pfam PF01546 Peptidase family M20/M25/M40 82 443 6.1E-38 T 21-04-2016 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 PANTHER PTHR11014 1 264 1.4E-195 T 21-04-2016 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 PANTHER PTHR11014 282 456 1.4E-195 T 21-04-2016 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 PANTHER PTHR11014:SF72 1 264 1.4E-195 T 21-04-2016 SPH21_RS15450 c3f8cb36eb381be61b2286b71c96c7ac 456 PANTHER PTHR11014:SF72 282 456 1.4E-195 T 21-04-2016 SPH21_RS15135 455b2b49883a533562297e6ff373a3db 351 Pfam PF04245 37-kD nucleoid-associated bacterial protein 14 324 9.5E-33 T 21-04-2016 IPR007358 Nucleoid-associated protein NdpA GO:0009295 SPH21_RS12260 684d5f5595961d5acfcedd11659f1c7e 284 Pfam PF01145 SPFH domain / Band 7 family 54 228 2.0E-20 T 21-04-2016 IPR001107 Band 7 domain SPH21_RS12260 684d5f5595961d5acfcedd11659f1c7e 284 PANTHER PTHR10264 244 259 2.5E-61 T 21-04-2016 IPR001972 Stomatin family GO:0016020 SPH21_RS12260 684d5f5595961d5acfcedd11659f1c7e 284 PANTHER PTHR10264 42 221 2.5E-61 T 21-04-2016 IPR001972 Stomatin family GO:0016020 SPH21_RS12260 684d5f5595961d5acfcedd11659f1c7e 284 SUPERFAMILY SSF117892 88 219 1.01E-7 T 21-04-2016 IPR001107 Band 7 domain SPH21_RS12260 684d5f5595961d5acfcedd11659f1c7e 284 SMART SM00244 50 216 2.6E-6 T 21-04-2016 IPR001107 Band 7 domain SPH21_RS12260 684d5f5595961d5acfcedd11659f1c7e 284 PANTHER PTHR10264:SF46 244 259 2.5E-61 T 21-04-2016 SPH21_RS12260 684d5f5595961d5acfcedd11659f1c7e 284 PANTHER PTHR10264:SF46 42 221 2.5E-61 T 21-04-2016 SPH21_RS23130 2b06b109f1ca1884fbb234f3502cda90 150 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 29 77 5.4E-18 T 21-04-2016 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS23130 2b06b109f1ca1884fbb234f3502cda90 150 PANTHER PTHR34846:SF2 22 137 5.3E-15 T 21-04-2016 SPH21_RS23130 2b06b109f1ca1884fbb234f3502cda90 150 SUPERFAMILY SSF69118 13 143 1.25E-44 T 21-04-2016 IPR029032 AhpD-like SPH21_RS23130 2b06b109f1ca1884fbb234f3502cda90 150 Pfam PF02627 Carboxymuconolactone decarboxylase family 15 94 5.0E-19 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS23130 2b06b109f1ca1884fbb234f3502cda90 150 PANTHER PTHR34846 22 137 5.3E-15 T 21-04-2016 SPH21_RS23130 2b06b109f1ca1884fbb234f3502cda90 150 Gene3D G3DSA:1.20.1290.10 4 144 1.4E-51 T 21-04-2016 IPR029032 AhpD-like SPH21_RS13080 17d3e378d224ebc31e3fe7f66a26aafa 368 PANTHER PTHR10361 59 356 4.7E-82 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS13080 17d3e378d224ebc31e3fe7f66a26aafa 368 Pfam PF01758 Sodium Bile acid symporter family 91 263 1.1E-38 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS06590 389371c0693c2f9da6135a4aec7f1b90 259 Gene3D G3DSA:3.40.192.10 1 121 2.9E-31 T 21-04-2016 SPH21_RS06590 389371c0693c2f9da6135a4aec7f1b90 259 Pfam PF08501 Shikimate dehydrogenase substrate binding domain 6 88 4.5E-19 T 21-04-2016 IPR013708 Shikimate dehydrogenase substrate binding, N-terminal GO:0004764|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163|UniPathway: UPA00053 SPH21_RS06590 389371c0693c2f9da6135a4aec7f1b90 259 Gene3D G3DSA:3.40.50.720 122 258 2.5E-36 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06590 389371c0693c2f9da6135a4aec7f1b90 259 PANTHER PTHR21089:SF1 1 257 7.7E-62 T 21-04-2016 SPH21_RS06590 389371c0693c2f9da6135a4aec7f1b90 259 SUPERFAMILY SSF51735 117 258 2.64E-28 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06590 389371c0693c2f9da6135a4aec7f1b90 259 SUPERFAMILY SSF53223 2 93 6.91E-18 T 21-04-2016 SPH21_RS06590 389371c0693c2f9da6135a4aec7f1b90 259 PANTHER PTHR21089 1 257 7.7E-62 T 21-04-2016 SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 Pfam PF00288 GHMP kinases N terminal domain 83 136 8.2E-8 T 21-04-2016 IPR006204 GHMP kinase N-terminal domain GO:0005524 SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 Pfam PF08544 GHMP kinases C terminal 217 258 1.5E-7 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 TIGRFAM TIGR00154 ispE: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase 5 254 6.1E-51 T 21-04-2016 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 PANTHER PTHR20861:SF2 1 257 3.6E-70 T 21-04-2016 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 SUPERFAMILY SSF54211 1 152 5.24E-36 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 Gene3D G3DSA:3.30.70.890 159 259 9.6E-27 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 Gene3D G3DSA:3.30.230.10 3 154 5.9E-44 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 PANTHER PTHR20861 1 257 3.6E-70 T 21-04-2016 SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 SUPERFAMILY SSF55060 160 262 2.37E-20 T 21-04-2016 IPR013750 GHMP kinase, C-terminal domain SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 Hamap MF_00061 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [ispE]. 1 266 28.748 T 21-04-2016 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS14820 9e8b910e7f337318c74dea90f9095f34 274 PIRSF PIRSF010376 1 264 1.9E-72 T 21-04-2016 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560|UniPathway: UPA00056 SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 PANTHER PTHR11358:SF35 4 323 4.3E-86 T 21-04-2016 SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 Hamap MF_00737 Formimidoylglutamase [hutG]. 5 318 37.292 T 21-04-2016 IPR005923 Formiminoglutamase GO:0019556|GO:0050415 KEGG: 00340+3.5.3.8|UniPathway: UPA00379 SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 SUPERFAMILY SSF52768 19 316 3.96E-73 T 21-04-2016 SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 Pfam PF00491 Arginase family 43 315 4.9E-57 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 Gene3D G3DSA:3.40.800.10 4 318 2.1E-94 T 21-04-2016 IPR023696 Ureohydrolase domain SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 PIRSF PIRSF036979 26 322 1.0E-31 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 TIGRFAM TIGR01227 hutG: formimidoylglutamase 18 316 1.4E-86 T 21-04-2016 IPR005923 Formiminoglutamase GO:0019556|GO:0050415 KEGG: 00340+3.5.3.8|UniPathway: UPA00379 SPH21_RS16435 9e7e3541ee0fbedb90001098e1d47748 323 PANTHER PTHR11358 4 323 4.3E-86 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS11270 f262d9b37fe5bd9ec10539d461d2cb02 130 Gene3D G3DSA:1.20.1440.60 14 125 4.1E-29 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS11270 f262d9b37fe5bd9ec10539d461d2cb02 130 TIGRFAM TIGR02436 TIGR02436: four helix bundle protein 16 123 2.2E-27 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS11270 f262d9b37fe5bd9ec10539d461d2cb02 130 PANTHER PTHR38471 45 129 2.2E-19 T 21-04-2016 SPH21_RS11270 f262d9b37fe5bd9ec10539d461d2cb02 130 PANTHER PTHR38471:SF1 45 129 2.2E-19 T 21-04-2016 SPH21_RS11270 f262d9b37fe5bd9ec10539d461d2cb02 130 PIRSF PIRSF035652 12 129 1.1E-25 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS11270 f262d9b37fe5bd9ec10539d461d2cb02 130 SUPERFAMILY SSF158446 15 120 1.28E-24 T 21-04-2016 SPH21_RS11270 f262d9b37fe5bd9ec10539d461d2cb02 130 Pfam PF05635 23S rRNA-intervening sequence protein 18 117 1.3E-20 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS26375 e5faf8cf2cd867cebfd5ee21d09c8545 190 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 6.2E-9 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS26375 e5faf8cf2cd867cebfd5ee21d09c8545 190 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 6.2E-9 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS26375 e5faf8cf2cd867cebfd5ee21d09c8545 190 SUPERFAMILY SSF46689 4 75 6.48E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26375 e5faf8cf2cd867cebfd5ee21d09c8545 190 Gene3D G3DSA:1.10.357.10 5 188 3.8E-26 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS26375 e5faf8cf2cd867cebfd5ee21d09c8545 190 PANTHER PTHR30055:SF82 2 190 2.1E-26 T 21-04-2016 SPH21_RS26375 e5faf8cf2cd867cebfd5ee21d09c8545 190 PANTHER PTHR30055 2 190 2.1E-26 T 21-04-2016 SPH21_RS26375 e5faf8cf2cd867cebfd5ee21d09c8545 190 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 3.5E-13 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 PANTHER PTHR32347:SF12 11 361 1.0E-56 T 21-04-2016 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 PANTHER PTHR32347:SF12 384 448 1.0E-56 T 21-04-2016 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 Gene3D G3DSA:2.40.50.100 201 224 3.1E-14 T 21-04-2016 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 Gene3D G3DSA:2.40.50.100 65 98 3.1E-14 T 21-04-2016 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 SUPERFAMILY SSF111369 53 258 7.19E-20 T 21-04-2016 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 PANTHER PTHR32347 11 361 1.0E-56 T 21-04-2016 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 PANTHER PTHR32347 384 448 1.0E-56 T 21-04-2016 SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 50 286 8.8E-19 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS20530 a4725b5fbb0e38842108621859860d31 453 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 42 304 4.6E-35 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS18995 63eff32681983a95f6748af14fb41f8c 321 TIGRFAM TIGR03557 F420_G6P_family: F420-dependent oxidoreductase, G6PDH family 5 319 5.5E-67 T 21-04-2016 IPR019945 F420-dependent glucose-6-phosphate dehydrogenase-related SPH21_RS18995 63eff32681983a95f6748af14fb41f8c 321 Pfam PF00296 Luciferase-like monooxygenase 10 235 5.4E-36 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS18995 63eff32681983a95f6748af14fb41f8c 321 SUPERFAMILY SSF51679 7 319 1.45E-44 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS18995 63eff32681983a95f6748af14fb41f8c 321 Gene3D G3DSA:3.20.20.30 4 319 2.4E-49 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS18995 63eff32681983a95f6748af14fb41f8c 321 PANTHER PTHR30011 1 320 1.3E-56 T 21-04-2016 SPH21_RS18995 63eff32681983a95f6748af14fb41f8c 321 PANTHER PTHR30011:SF27 1 320 1.3E-56 T 21-04-2016 SPH21_RS18995 63eff32681983a95f6748af14fb41f8c 321 TIGRFAM TIGR03885 flavin_revert: probable non-F420 flavinoid oxidoreductase 4 318 9.5E-137 T 21-04-2016 IPR023907 Non-F420 flavinoid oxidoreductase SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 SMART SM00421 131 187 0.0068 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 PANTHER PTHR30173 1 178 7.6E-31 T 21-04-2016 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 Gene3D G3DSA:1.10.1740.10 10 110 2.7E-16 T 21-04-2016 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 Pfam PF04542 Sigma-70 region 2 30 95 1.5E-5 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 Pfam PF08281 Sigma-70, region 4 130 177 3.3E-16 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 26 179 1.1E-20 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 177 3.2E-7 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 149 165 3.2E-7 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 SUPERFAMILY SSF88659 130 179 4.19E-14 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 Gene3D G3DSA:1.10.10.10 123 180 1.8E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS08795 51bbc475b7cf37720846fb139af70674 192 SUPERFAMILY SSF88946 10 108 2.51E-13 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 Pfam PF00512 His Kinase A (phospho-acceptor) domain 356 419 8.9E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PANTHER PTHR24423 335 758 3.7E-99 T 21-04-2016 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PANTHER PTHR24423 44 65 3.7E-99 T 21-04-2016 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 SUPERFAMILY SSF52172 603 715 3.98E-20 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 SUPERFAMILY SSF55874 408 581 1.57E-42 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 SMART SM00388 356 419 4.6E-20 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 SUPERFAMILY SSF47226 697 834 1.22E-13 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 Pfam PF00072 Response regulator receiver domain 604 712 5.1E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 466 580 9.0E-27 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 Gene3D G3DSA:1.10.287.130 349 415 5.4E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 SMART SM00387 466 581 1.6E-35 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 SMART SM00448 602 714 6.6E-11 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PANTHER PTHR24423:SF374 335 758 3.7E-99 T 21-04-2016 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PANTHER PTHR24423:SF374 44 65 3.7E-99 T 21-04-2016 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 SUPERFAMILY SSF47384 341 420 3.14E-19 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 Gene3D G3DSA:1.20.120.160 738 841 9.3E-11 T 21-04-2016 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain GO:0000160|GO:0004871 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PRINTS PR00344 Bacterial sensor protein C-terminal signature 524 534 3.4E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PRINTS PR00344 Bacterial sensor protein C-terminal signature 506 520 3.4E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PRINTS PR00344 Bacterial sensor protein C-terminal signature 541 559 3.4E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 PRINTS PR00344 Bacterial sensor protein C-terminal signature 565 578 3.4E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 Gene3D G3DSA:3.40.50.2300 603 714 8.8E-21 T 21-04-2016 SPH21_RS15675 88b492bd5b0e27fb7987583f517acc29 850 Gene3D G3DSA:3.30.565.10 420 582 2.0E-44 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06070 4cf8d30607270ffe075296a1b13d6cc1 136 PANTHER PTHR40052 1 136 9.5E-55 T 21-04-2016 SPH21_RS06070 4cf8d30607270ffe075296a1b13d6cc1 136 PANTHER PTHR40052:SF2 1 136 9.5E-55 T 21-04-2016 SPH21_RS06070 4cf8d30607270ffe075296a1b13d6cc1 136 TIGRFAM TIGR04191 YphP_YqiW: putative bacilliredoxin, YphP/YqiW family 2 136 2.8E-64 T 21-04-2016 IPR009474 Putative bacilliredoxin, YphP/YqiW family SPH21_RS06070 4cf8d30607270ffe075296a1b13d6cc1 136 Pfam PF06491 Disulphide isomerase 2 136 2.2E-65 T 21-04-2016 IPR009474 Putative bacilliredoxin, YphP/YqiW family SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 Gene3D G3DSA:2.40.170.20 247 807 1.0E-104 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 Pfam PF07715 TonB-dependent Receptor Plug Domain 131 225 1.2E-15 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 SUPERFAMILY SSF56935 98 807 7.85E-109 T 21-04-2016 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 Gene3D G3DSA:2.60.40.1120 26 102 4.7E-17 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 Pfam PF00593 TonB dependent receptor 560 806 3.0E-29 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 Pfam PF13715 CarboxypepD_reg-like domain 26 112 1.0E-18 T 21-04-2016 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 SUPERFAMILY SSF49464 25 117 8.63E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 Gene3D G3DSA:2.170.130.10 120 240 8.4E-28 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 PANTHER PTHR32552 101 807 1.1E-93 T 21-04-2016 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 PANTHER PTHR32552:SF10 101 807 1.1E-93 T 21-04-2016 SPH21_RS04970 41cec3583618422b8e493f7286c211c4 807 TIGRFAM TIGR01783 TonB-siderophor: TonB-dependent siderophore receptor 136 807 1.3E-72 T 21-04-2016 IPR010105 TonB-dependent siderophore receptor GO:0004872|GO:0005506|GO:0015891 SPH21_RS02100 27c36904f7b93f12536383d0eeec1de8 310 SUPERFAMILY SSF109709 131 241 1.73E-36 T 21-04-2016 SPH21_RS02100 27c36904f7b93f12536383d0eeec1de8 310 PANTHER PTHR33375 48 310 1.3E-96 T 21-04-2016 SPH21_RS02100 27c36904f7b93f12536383d0eeec1de8 310 Gene3D G3DSA:3.90.1530.10 46 145 1.0E-38 T 21-04-2016 SPH21_RS02100 27c36904f7b93f12536383d0eeec1de8 310 TIGRFAM TIGR00180 parB_part: ParB/RepB/Spo0J family partition protein 48 224 1.1E-53 T 21-04-2016 IPR004437 ParB/RepB/Spo0J partition protein family GO:0003677 SPH21_RS02100 27c36904f7b93f12536383d0eeec1de8 310 Pfam PF02195 ParB-like nuclease domain 50 139 2.6E-25 T 21-04-2016 IPR003115 ParB/Sulfiredoxin SPH21_RS02100 27c36904f7b93f12536383d0eeec1de8 310 SUPERFAMILY SSF110849 50 141 6.8E-29 T 21-04-2016 IPR003115 ParB/Sulfiredoxin SPH21_RS02100 27c36904f7b93f12536383d0eeec1de8 310 SMART SM00470 49 139 8.8E-33 T 21-04-2016 IPR003115 ParB/Sulfiredoxin SPH21_RS06270 a56c72d3e7241750a04a7304b81cacec 172 SUPERFAMILY SSF109854 5 163 3.05E-12 T 21-04-2016 SPH21_RS06270 a56c72d3e7241750a04a7304b81cacec 172 Gene3D G3DSA:1.20.120.450 4 166 7.2E-14 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS06270 a56c72d3e7241750a04a7304b81cacec 172 Pfam PF12867 DinB superfamily 12 161 7.6E-11 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 12 341 8.2E-145 T 21-04-2016 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 PANTHER PTHR11624 6 317 0.0 T 21-04-2016 IPR033247 Transketolase family SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 PANTHER PTHR11624 344 669 0.0 T 21-04-2016 IPR033247 Transketolase family SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 TIGRFAM TIGR00232 tktlase_bact: transketolase 13 667 1.5E-273 T 21-04-2016 IPR005478 Transketolase, bacterial-like GO:0004802 KEGG: 00030+2.2.1.1|KEGG: 00710+2.2.1.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|MetaCyc: PWY-6901 SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 Gene3D G3DSA:3.40.50.920 542 668 1.8E-51 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 Gene3D G3DSA:3.40.50.970 337 534 1.2E-70 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 Gene3D G3DSA:3.40.50.970 12 322 2.1E-119 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 SUPERFAMILY SSF52518 10 325 2.83E-110 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 Pfam PF02780 Transketolase, C-terminal domain 547 659 1.6E-14 T 21-04-2016 IPR033248 Transketolase, C-terminal domain SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 Pfam PF02779 Transketolase, pyrimidine binding domain 356 527 8.1E-43 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 SUPERFAMILY SSF52518 344 530 6.49E-65 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 ProSitePatterns PS00801 Transketolase signature 1. 18 38 - T 21-04-2016 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 PANTHER PTHR11624:SF1 6 317 0.0 T 21-04-2016 SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 PANTHER PTHR11624:SF1 344 669 0.0 T 21-04-2016 SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 SUPERFAMILY SSF52922 538 668 4.19E-43 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS10780 a89625b99ffb78335180a6de79f1d9dd 669 SMART SM00861 357 528 2.4E-61 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 PANTHER PTHR11228:SF6 11 206 1.2E-32 T 21-04-2016 SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 PANTHER PTHR11228 11 206 1.2E-32 T 21-04-2016 SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 Pfam PF13394 4Fe-4S single cluster domain 33 113 5.0E-14 T 21-04-2016 SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 Gene3D G3DSA:3.20.20.70 27 110 2.0E-10 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 Pfam PF04055 Radical SAM superfamily 36 113 4.3E-9 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 SUPERFAMILY SSF102114 28 113 6.02E-11 T 21-04-2016 SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 Hamap MF_00917 7-carboxy-7-deazaguanine synthase [queE]. 12 207 36.846 T 21-04-2016 IPR024924 7-carboxy-7-deazaguanine synthase-like KEGG: 00790+4.3.99.3|MetaCyc: PWY-6703|UniPathway: UPA00391 SPH21_RS16385 478cd04f6f41ce1ab48f8e2e9a885fb7 207 PIRSF PIRSF000370 10 207 3.4E-52 T 21-04-2016 IPR024924 7-carboxy-7-deazaguanine synthase-like KEGG: 00790+4.3.99.3|MetaCyc: PWY-6703|UniPathway: UPA00391 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 Pfam PF04542 Sigma-70 region 2 25 91 3.6E-6 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 SUPERFAMILY SSF88946 1 106 1.84E-17 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 20 179 2.4E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 Pfam PF08281 Sigma-70, region 4 125 176 4.5E-15 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 Gene3D G3DSA:1.10.1740.10 2 102 1.7E-15 T 21-04-2016 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 SUPERFAMILY SSF88659 121 187 1.16E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 PANTHER PTHR30173 1 182 2.1E-35 T 21-04-2016 SPH21_RS14660 bcb88b1c206b25e0da09d0f7b66c4f39 198 Gene3D G3DSA:1.10.10.10 118 182 4.5E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21230 0feb111433fe8773a118fbd2c81b42f5 306 Gene3D G3DSA:3.30.420.40 10 117 6.7E-7 T 21-04-2016 SPH21_RS21230 0feb111433fe8773a118fbd2c81b42f5 306 PANTHER PTHR18964:SF121 14 296 2.3E-16 T 21-04-2016 SPH21_RS21230 0feb111433fe8773a118fbd2c81b42f5 306 SUPERFAMILY SSF53067 13 295 1.24E-28 T 21-04-2016 SPH21_RS21230 0feb111433fe8773a118fbd2c81b42f5 306 PANTHER PTHR18964 14 296 2.3E-16 T 21-04-2016 SPH21_RS21230 0feb111433fe8773a118fbd2c81b42f5 306 Pfam PF00480 ROK family 202 295 1.1E-6 T 21-04-2016 IPR000600 ROK family SPH21_RS21230 0feb111433fe8773a118fbd2c81b42f5 306 Pfam PF00480 ROK family 14 161 5.3E-9 T 21-04-2016 IPR000600 ROK family SPH21_RS21230 0feb111433fe8773a118fbd2c81b42f5 306 Gene3D G3DSA:3.30.420.40 127 295 9.2E-19 T 21-04-2016 SPH21_RS08860 7a10be658502830ca2169d2258ba316b 270 PANTHER PTHR22916 7 136 3.8E-61 T 21-04-2016 SPH21_RS08860 7a10be658502830ca2169d2258ba316b 270 PANTHER PTHR22916 161 249 3.8E-61 T 21-04-2016 SPH21_RS08860 7a10be658502830ca2169d2258ba316b 270 Gene3D G3DSA:3.90.550.10 7 255 5.4E-36 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08860 7a10be658502830ca2169d2258ba316b 270 PANTHER PTHR22916:SF16 7 136 3.8E-61 T 21-04-2016 SPH21_RS08860 7a10be658502830ca2169d2258ba316b 270 PANTHER PTHR22916:SF16 161 249 3.8E-61 T 21-04-2016 SPH21_RS08860 7a10be658502830ca2169d2258ba316b 270 SUPERFAMILY SSF53448 3 252 1.18E-42 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08860 7a10be658502830ca2169d2258ba316b 270 Pfam PF00535 Glycosyl transferase family 2 12 123 6.4E-16 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS11645 78e287f15b70c1233a19d845e6a89454 264 Pfam PF02754 Cysteine-rich domain 23 108 6.1E-15 T 21-04-2016 IPR004017 Cysteine-rich domain SPH21_RS11645 78e287f15b70c1233a19d845e6a89454 264 Pfam PF02754 Cysteine-rich domain 149 237 5.7E-17 T 21-04-2016 IPR004017 Cysteine-rich domain SPH21_RS11645 78e287f15b70c1233a19d845e6a89454 264 PANTHER PTHR11921:SF22 12 264 3.9E-112 T 21-04-2016 SPH21_RS11645 78e287f15b70c1233a19d845e6a89454 264 PANTHER PTHR11921 12 264 3.9E-112 T 21-04-2016 SPH21_RS19600 13a3fbf6cf092e4b3f487c7da722ca8b 200 SUPERFAMILY SSF54534 6 198 6.09E-49 T 21-04-2016 SPH21_RS19600 13a3fbf6cf092e4b3f487c7da722ca8b 200 PANTHER PTHR10516:SF320 78 198 2.4E-51 T 21-04-2016 SPH21_RS19600 13a3fbf6cf092e4b3f487c7da722ca8b 200 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 110 196 5.0E-24 T 21-04-2016 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SPH21_RS19600 13a3fbf6cf092e4b3f487c7da722ca8b 200 Gene3D G3DSA:3.10.50.40 81 198 2.7E-49 T 21-04-2016 SPH21_RS19600 13a3fbf6cf092e4b3f487c7da722ca8b 200 PANTHER PTHR10516 78 198 2.4E-51 T 21-04-2016 IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type SPH21_RS19600 13a3fbf6cf092e4b3f487c7da722ca8b 200 Gene3D G3DSA:1.10.287.460 2 80 9.8E-18 T 21-04-2016 IPR000774 Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal GO:0006457 SPH21_RS19600 13a3fbf6cf092e4b3f487c7da722ca8b 200 Pfam PF01346 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase 3 101 3.0E-18 T 21-04-2016 IPR000774 Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal GO:0006457 SPH21_RS16015 8bd8a2b85f3af0b4474df2c42194289b 126 Gene3D G3DSA:2.60.40.360 28 124 2.7E-27 T 21-04-2016 IPR008962 PapD-like SPH21_RS16015 8bd8a2b85f3af0b4474df2c42194289b 126 Pfam PF07610 Protein of unknown function (DUF1573) 50 93 4.2E-21 T 21-04-2016 IPR011467 Protein of unknown function DUF1573 SPH21_RS16015 8bd8a2b85f3af0b4474df2c42194289b 126 PANTHER PTHR37833 4 125 1.6E-25 T 21-04-2016 SPH21_RS16015 8bd8a2b85f3af0b4474df2c42194289b 126 PANTHER PTHR37833:SF1 4 125 1.6E-25 T 21-04-2016 SPH21_RS01880 954672927400c4731ba4804f9f6dedd8 318 PANTHER PTHR21091:SF31 177 304 1.9E-36 T 21-04-2016 SPH21_RS01880 954672927400c4731ba4804f9f6dedd8 318 TIGRFAM TIGR00676 fadh2: methylenetetrahydrofolate reductase [NAD(P)H] 16 316 2.0E-89 T 21-04-2016 IPR004620 5,10-methylenetetrahydrofolate reductase GO:0004489|GO:0005829|GO:0009086|GO:0055114 KEGG: 00670+1.5.1.20|KEGG: 00720+1.5.1.20|MetaCyc: PWY-2201|MetaCyc: PWY-3841|UniPathway: UPA00193 SPH21_RS01880 954672927400c4731ba4804f9f6dedd8 318 PANTHER PTHR21091 177 304 1.9E-36 T 21-04-2016 SPH21_RS01880 954672927400c4731ba4804f9f6dedd8 318 Gene3D G3DSA:3.20.20.220 1 316 9.3E-92 T 21-04-2016 IPR029041 FAD-linked oxidoreductase-like SPH21_RS01880 954672927400c4731ba4804f9f6dedd8 318 Pfam PF02219 Methylenetetrahydrofolate reductase 6 315 1.1E-66 T 21-04-2016 IPR003171 Methylenetetrahydrofolate reductase GO:0004489|GO:0006555|GO:0055114 KEGG: 00670+1.5.1.20|KEGG: 00720+1.5.1.20|MetaCyc: PWY-2201|MetaCyc: PWY-3841|UniPathway: UPA00193 SPH21_RS01880 954672927400c4731ba4804f9f6dedd8 318 SUPERFAMILY SSF51730 2 315 4.51E-87 T 21-04-2016 IPR029041 FAD-linked oxidoreductase-like SPH21_RS19370 eb23bb224f5fde246df9efc07fc8b754 504 Pfam PF07980 SusD family 374 504 7.1E-18 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS19370 eb23bb224f5fde246df9efc07fc8b754 504 Gene3D G3DSA:1.25.40.10 192 307 1.1E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19370 eb23bb224f5fde246df9efc07fc8b754 504 Gene3D G3DSA:1.25.40.10 371 454 1.1E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19370 eb23bb224f5fde246df9efc07fc8b754 504 SUPERFAMILY SSF48452 17 331 1.26E-84 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19370 eb23bb224f5fde246df9efc07fc8b754 504 SUPERFAMILY SSF48452 358 504 1.26E-84 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14605 e520053025a2d03d5dae848b62ebbd0e 679 Gene3D G3DSA:1.10.150.320 59 121 2.8E-5 T 21-04-2016 SPH21_RS14605 e520053025a2d03d5dae848b62ebbd0e 679 Pfam PF12836 Helix-hairpin-helix motif 59 120 1.3E-10 T 21-04-2016 SPH21_RS14605 e520053025a2d03d5dae848b62ebbd0e 679 SUPERFAMILY SSF47781 52 122 8.23E-10 T 21-04-2016 IPR010994 RuvA domain 2-like Reactome: REACT_216 SPH21_RS10700 6efe8febf0c93ec40171803bbe0be09e 118 SMART SM00448 3 113 2.7E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10700 6efe8febf0c93ec40171803bbe0be09e 118 Gene3D G3DSA:3.40.50.2300 2 117 2.1E-25 T 21-04-2016 SPH21_RS10700 6efe8febf0c93ec40171803bbe0be09e 118 SUPERFAMILY SSF52172 2 117 1.99E-24 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10700 6efe8febf0c93ec40171803bbe0be09e 118 Pfam PF00072 Response regulator receiver domain 5 114 1.1E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10700 6efe8febf0c93ec40171803bbe0be09e 118 PANTHER PTHR26402 3 117 1.9E-24 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 Gene3D G3DSA:2.60.40.1120 35 120 6.9E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 SUPERFAMILY SSF49464 34 115 2.35E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 Pfam PF13715 CarboxypepD_reg-like domain 36 117 4.6E-18 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 Pfam PF07715 TonB-dependent Receptor Plug Domain 125 229 3.2E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 Gene3D G3DSA:2.170.130.10 121 233 2.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 SUPERFAMILY SSF56935 842 886 6.41E-83 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 SUPERFAMILY SSF56935 295 382 6.41E-83 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 SUPERFAMILY SSF56935 414 769 6.41E-83 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 SUPERFAMILY SSF56935 923 1014 6.41E-83 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 SUPERFAMILY SSF56935 113 253 6.41E-83 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 Gene3D G3DSA:2.40.170.20 670 769 2.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 Gene3D G3DSA:2.40.170.20 298 633 2.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 Gene3D G3DSA:2.40.170.20 842 897 2.7E-21 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 205 235 2.7E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 PANTHER PTHR11532 14 411 6.8E-242 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 PANTHER PTHR11532 487 1012 6.8E-242 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 35 1014 3.7E-251 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 PANTHER PTHR11532:SF57 14 411 6.8E-242 T 21-04-2016 SPH21_RS02900 da298c3af698583d3463a1f16a5edf16 1014 PANTHER PTHR11532:SF57 487 1012 6.8E-242 T 21-04-2016 SPH21_RS08470 81da9b484f552c24e679ee1ca4ff6874 801 TIGRFAM TIGR03521 GldG: gliding-associated putative ABC transporter substrate-binding component GldG 249 800 2.8E-180 T 21-04-2016 IPR019863 Gliding-associated putative ABC transporter substrate-binding GldG SPH21_RS08470 81da9b484f552c24e679ee1ca4ff6874 801 PANTHER PTHR30294:SF5 4 260 4.6E-34 T 21-04-2016 SPH21_RS08470 81da9b484f552c24e679ee1ca4ff6874 801 Pfam PF12679 ABC-2 family transporter protein 58 273 7.7E-14 T 21-04-2016 IPR032688 ABC-2 family transporter protein GO:0006810 SPH21_RS08470 81da9b484f552c24e679ee1ca4ff6874 801 Pfam PF09822 ABC-type uncharacterized transport system 271 552 4.4E-64 T 21-04-2016 IPR019196 ABC-type uncharacterised transport system SPH21_RS08470 81da9b484f552c24e679ee1ca4ff6874 801 PANTHER PTHR30294 4 260 4.6E-34 T 21-04-2016 SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 SMART SM00829 10 316 8.8E-14 T 21-04-2016 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 PANTHER PTHR11695 15 317 4.8E-77 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 SUPERFAMILY SSF50129 1 156 2.74E-35 T 21-04-2016 IPR011032 GroES-like SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 90 5.4E-8 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 SUPERFAMILY SSF51735 124 241 6.78E-30 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 Gene3D G3DSA:3.40.50.720 155 239 1.2E-18 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 Pfam PF13602 Zinc-binding dehydrogenase 193 316 2.6E-19 T 21-04-2016 SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 Gene3D G3DSA:3.90.180.10 1 154 1.4E-39 T 21-04-2016 IPR011032 GroES-like SPH21_RS20800 0692b068eecef7cd66861c15228b2d90 319 PANTHER PTHR11695:SF294 15 317 4.8E-77 T 21-04-2016 SPH21_RS22810 eebff1365d77e6d9fe71da03bf2fc5fd 139 SUPERFAMILY SSF46785 19 121 6.1E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22810 eebff1365d77e6d9fe71da03bf2fc5fd 139 Gene3D G3DSA:1.10.10.10 8 117 7.7E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22810 eebff1365d77e6d9fe71da03bf2fc5fd 139 PANTHER PTHR33204 9 116 6.2E-22 T 21-04-2016 SPH21_RS22810 eebff1365d77e6d9fe71da03bf2fc5fd 139 Pfam PF01638 HxlR-like helix-turn-helix 31 118 4.7E-19 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS10200 e37192072d33882398ee49f34fdc268c 328 Pfam PF13439 Glycosyltransferase Family 4 34 145 2.0E-16 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS10200 e37192072d33882398ee49f34fdc268c 328 PANTHER PTHR12526 59 328 5.4E-55 T 21-04-2016 SPH21_RS10200 e37192072d33882398ee49f34fdc268c 328 Pfam PF00534 Glycosyl transferases group 1 146 309 3.6E-33 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS10200 e37192072d33882398ee49f34fdc268c 328 Gene3D G3DSA:3.40.50.2000 136 309 3.4E-23 T 21-04-2016 SPH21_RS10200 e37192072d33882398ee49f34fdc268c 328 SUPERFAMILY SSF53756 39 325 1.03E-68 T 21-04-2016 SPH21_RS23010 9e7135e8a703382fdc834d778f158039 218 Pfam PF01144 Coenzyme A transferase 7 200 2.9E-39 T 21-04-2016 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SPH21_RS23010 9e7135e8a703382fdc834d778f158039 218 PANTHER PTHR13707 7 216 2.7E-121 T 21-04-2016 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SPH21_RS23010 9e7135e8a703382fdc834d778f158039 218 TIGRFAM TIGR02428 pcaJ_scoB_fam: 3-oxoacid CoA-transferase, B subunit 3 208 6.1E-96 T 21-04-2016 IPR012791 3-oxoacid CoA-transferase, subunit B GO:0008410 SPH21_RS23010 9e7135e8a703382fdc834d778f158039 218 Gene3D G3DSA:3.40.810.20 5 213 1.7E-88 T 21-04-2016 SPH21_RS23010 9e7135e8a703382fdc834d778f158039 218 ProSitePatterns PS01274 Coenzyme A transferases signature 2. 43 51 - T 21-04-2016 IPR004164 Coenzyme A transferase active site GO:0008152|GO:0008410 SPH21_RS23010 9e7135e8a703382fdc834d778f158039 218 SUPERFAMILY SSF100950 5 217 1.15E-71 T 21-04-2016 SPH21_RS23010 9e7135e8a703382fdc834d778f158039 218 SMART SM00882 5 202 2.3E-74 T 21-04-2016 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SPH21_RS15755 0c0a4d1c5bfcce8bb2dded85e3869817 718 Pfam PF13515 Fusaric acid resistance protein-like 402 524 1.5E-19 T 21-04-2016 SPH21_RS15755 0c0a4d1c5bfcce8bb2dded85e3869817 718 Pfam PF12805 FUSC-like inner membrane protein yccS 68 346 3.3E-53 T 21-04-2016 IPR032692 Integral membrane protein YccS, N-terminal SPH21_RS15755 0c0a4d1c5bfcce8bb2dded85e3869817 718 PANTHER PTHR30509:SF8 2 707 1.9E-57 T 21-04-2016 SPH21_RS15755 0c0a4d1c5bfcce8bb2dded85e3869817 718 PANTHER PTHR30509 2 707 1.9E-57 T 21-04-2016 SPH21_RS12005 442432fa28d66136051404bbc1e5ec86 188 SUPERFAMILY SSF55821 6 187 1.43E-44 T 21-04-2016 IPR017945 DHBP synthase RibB-like alpha/beta domain SPH21_RS12005 442432fa28d66136051404bbc1e5ec86 188 Gene3D G3DSA:3.90.870.10 3 187 1.5E-55 T 21-04-2016 IPR017945 DHBP synthase RibB-like alpha/beta domain SPH21_RS12005 442432fa28d66136051404bbc1e5ec86 188 Pfam PF01300 Telomere recombination 12 188 5.5E-45 T 21-04-2016 IPR006070 YrdC-like domain GO:0003725 SPH21_RS12005 442432fa28d66136051404bbc1e5ec86 188 TIGRFAM TIGR00057 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family 4 180 8.1E-49 T 21-04-2016 IPR006070 YrdC-like domain GO:0003725 SPH21_RS12005 442432fa28d66136051404bbc1e5ec86 188 PANTHER PTHR17490 5 188 3.1E-52 T 21-04-2016 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 Pfam PF12833 Helix-turn-helix domain 216 293 3.7E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 PANTHER PTHR11019 219 293 1.2E-22 T 21-04-2016 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 277 293 2.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 262 277 2.5E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 SUPERFAMILY SSF46689 249 293 8.06E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 SMART SM00342 210 293 4.5E-23 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 Gene3D G3DSA:1.10.10.60 248 293 3.8E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20755 0c30fd95a5647dea84863eed32df2e48 298 PANTHER PTHR11019:SF80 219 293 1.2E-22 T 21-04-2016 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 Pfam PF00085 Thioredoxin 3 95 6.1E-30 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 Gene3D G3DSA:3.40.30.10 3 97 3.4E-32 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 PIRSF PIRSF000077 1 98 4.0E-38 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 SUPERFAMILY SSF52833 2 97 7.93E-35 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 ProSitePatterns PS00194 Thioredoxin family active site. 15 33 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 TIGRFAM TIGR01068 thioredoxin: thioredoxin 3 96 2.4E-35 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 PANTHER PTHR10438 1 99 1.1E-34 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 PRINTS PR00421 Thioredoxin family signature 14 22 3.6E-9 T 21-04-2016 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 PRINTS PR00421 Thioredoxin family signature 62 73 3.6E-9 T 21-04-2016 SPH21_RS15945 349c12da190bf8877661d49178d29f3f 99 PRINTS PR00421 Thioredoxin family signature 22 31 3.6E-9 T 21-04-2016 SPH21_RS24030 81c59fdeaeeb03fe70913b6894a72134 150 Pfam PF02627 Carboxymuconolactone decarboxylase family 15 94 4.4E-18 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS24030 81c59fdeaeeb03fe70913b6894a72134 150 Gene3D G3DSA:1.20.1290.10 3 144 2.6E-51 T 21-04-2016 IPR029032 AhpD-like SPH21_RS24030 81c59fdeaeeb03fe70913b6894a72134 150 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 32 77 3.6E-18 T 21-04-2016 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS24030 81c59fdeaeeb03fe70913b6894a72134 150 PANTHER PTHR34846:SF2 15 137 3.0E-12 T 21-04-2016 SPH21_RS24030 81c59fdeaeeb03fe70913b6894a72134 150 PANTHER PTHR34846 15 137 3.0E-12 T 21-04-2016 SPH21_RS24030 81c59fdeaeeb03fe70913b6894a72134 150 SUPERFAMILY SSF69118 12 141 5.37E-42 T 21-04-2016 IPR029032 AhpD-like SPH21_RS08700 c13d4b2225fce78e0b696364cb788cc8 445 Pfam PF02321 Outer membrane efflux protein 36 231 6.0E-25 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS08700 c13d4b2225fce78e0b696364cb788cc8 445 Pfam PF02321 Outer membrane efflux protein 256 443 3.1E-20 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS08700 c13d4b2225fce78e0b696364cb788cc8 445 Gene3D G3DSA:1.20.1600.10 31 444 1.4E-59 T 21-04-2016 SPH21_RS08700 c13d4b2225fce78e0b696364cb788cc8 445 SUPERFAMILY SSF56954 8 444 5.75E-68 T 21-04-2016 SPH21_RS08700 c13d4b2225fce78e0b696364cb788cc8 445 PANTHER PTHR30026 29 445 3.1E-37 T 21-04-2016 SPH21_RS15940 bc5378b58ff48b0cc54ac7a30e6985f1 122 SUPERFAMILY SSF52172 4 120 4.7E-25 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS15940 bc5378b58ff48b0cc54ac7a30e6985f1 122 PANTHER PTHR26402 3 122 7.5E-23 T 21-04-2016 SPH21_RS15940 bc5378b58ff48b0cc54ac7a30e6985f1 122 Gene3D G3DSA:3.40.50.2300 4 121 2.2E-24 T 21-04-2016 SPH21_RS15940 bc5378b58ff48b0cc54ac7a30e6985f1 122 SMART SM00448 3 114 2.1E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15940 bc5378b58ff48b0cc54ac7a30e6985f1 122 Pfam PF00072 Response regulator receiver domain 5 112 1.1E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS07825 e8fc579d327a9cefaac45e617eb999a0 210 PANTHER PTHR30558 145 210 3.0E-14 T 21-04-2016 SPH21_RS07825 e8fc579d327a9cefaac45e617eb999a0 210 PANTHER PTHR30558 7 84 3.0E-14 T 21-04-2016 SPH21_RS07825 e8fc579d327a9cefaac45e617eb999a0 210 Pfam PF02472 Biopolymer transport protein ExbD/TolR 7 202 2.7E-23 T 21-04-2016 IPR003400 Biopolymer transport protein ExbD/TolR GO:0005215|GO:0006810|GO:0016020 SPH21_RS07825 e8fc579d327a9cefaac45e617eb999a0 210 PANTHER PTHR30558:SF3 145 210 3.0E-14 T 21-04-2016 SPH21_RS07825 e8fc579d327a9cefaac45e617eb999a0 210 PANTHER PTHR30558:SF3 7 84 3.0E-14 T 21-04-2016 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 PANTHER PTHR10986 2 114 1.4E-57 T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 ProDom PD002389 RIBOSOMAL RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN L20 50S L20 CHLOROPLAST BACTERIAL ORGANELLE 23 70 1.0E-15 T 21-04-2016 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 PRINTS PR00062 Ribosomal protein L20 signature 75 101 1.3E-37 T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 PRINTS PR00062 Ribosomal protein L20 signature 42 71 1.3E-37 T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 PRINTS PR00062 Ribosomal protein L20 signature 12 41 1.3E-37 T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 SUPERFAMILY SSF74731 3 114 1.29E-45 T 21-04-2016 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 Pfam PF00453 Ribosomal protein L20 3 108 4.7E-46 T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 TIGRFAM TIGR01032 rplT_bact: ribosomal protein bL20 1 114 9.3E-47 T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 Gene3D G3DSA:1.10.1900.20 55 114 3.1E-29 T 21-04-2016 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 Hamap MF_00382 50S ribosomal protein L20 [rplT]. 2 114 25.742 T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 PANTHER PTHR10986:SF12 2 114 1.4E-57 T 21-04-2016 SPH21_RS14765 e8763d30f2a0b17489b4bb9a1a88206a 114 ProSitePatterns PS00937 Ribosomal protein L20 signature. 54 70 - T 21-04-2016 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08990 8c31dc6c3ebed85ca019f984f52488f9 348 PANTHER PTHR22572:SF114 120 343 6.4E-65 T 21-04-2016 SPH21_RS08990 8c31dc6c3ebed85ca019f984f52488f9 348 Pfam PF00483 Nucleotidyl transferase 121 343 7.7E-38 T 21-04-2016 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 Reactome: REACT_17015 SPH21_RS08990 8c31dc6c3ebed85ca019f984f52488f9 348 Gene3D G3DSA:3.90.550.10 120 344 4.9E-61 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08990 8c31dc6c3ebed85ca019f984f52488f9 348 PANTHER PTHR22572 120 343 6.4E-65 T 21-04-2016 SPH21_RS08990 8c31dc6c3ebed85ca019f984f52488f9 348 SUPERFAMILY SSF53448 118 343 1.18E-62 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08990 8c31dc6c3ebed85ca019f984f52488f9 348 Gene3D G3DSA:3.10.580.10 30 113 3.6E-12 T 21-04-2016 SPH21_RS08990 8c31dc6c3ebed85ca019f984f52488f9 348 SUPERFAMILY SSF54631 31 116 4.8E-12 T 21-04-2016 SPH21_RS07820 ff12094c2179600ccbd1bc5281d50c8c 277 Pfam PF01618 MotA/TolQ/ExbB proton channel family 132 261 3.9E-30 T 21-04-2016 IPR002898 MotA/TolQ/ExbB proton channel GO:0006810|GO:0008565|GO:0016020 SPH21_RS07820 ff12094c2179600ccbd1bc5281d50c8c 277 PANTHER PTHR30625:SF7 20 276 2.2E-104 T 21-04-2016 SPH21_RS07820 ff12094c2179600ccbd1bc5281d50c8c 277 PANTHER PTHR30625 20 276 2.2E-104 T 21-04-2016 SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 Gene3D G3DSA:1.10.10.10 126 228 7.6E-32 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 Pfam PF00486 Transcriptional regulatory protein, C terminal 149 225 4.2E-24 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 PANTHER PTHR26402 5 228 1.3E-68 T 21-04-2016 SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 SUPERFAMILY SSF52172 4 181 4.23E-36 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 PANTHER PTHR26402:SF50 5 228 1.3E-68 T 21-04-2016 SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 Pfam PF00072 Response regulator receiver domain 7 117 3.7E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 SMART SM00862 149 225 2.1E-24 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 Gene3D G3DSA:3.40.50.2300 2 121 1.4E-32 T 21-04-2016 SPH21_RS07770 f4a0eb11f258035b4dffa3dc169e1b27 230 SMART SM00448 5 116 1.3E-33 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09335 160bf7863a6703d940e3fcb8b097f61e 382 Pfam PF04773 FecR protein 172 267 2.3E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS09335 160bf7863a6703d940e3fcb8b097f61e 382 PANTHER PTHR30273 174 363 2.8E-63 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09335 160bf7863a6703d940e3fcb8b097f61e 382 PANTHER PTHR30273 1 104 2.8E-63 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09335 160bf7863a6703d940e3fcb8b097f61e 382 PANTHER PTHR30273:SF2 174 363 2.8E-63 T 21-04-2016 SPH21_RS09335 160bf7863a6703d940e3fcb8b097f61e 382 PANTHER PTHR30273:SF2 1 104 2.8E-63 T 21-04-2016 SPH21_RS09335 160bf7863a6703d940e3fcb8b097f61e 382 Pfam PF16344 Domain of unknown function (DUF4974) 279 371 3.2E-20 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS15820 fbec321e582158752a28085fee16028a 169 PIRSF PIRSF001338 4 168 3.2E-72 T 21-04-2016 IPR024694 N5-carboxyaminoimidazole ribonucleotide mutase PurE GO:0006189|GO:0034023 KEGG: 00230+5.4.99.18|MetaCyc: PWY-6123|MetaCyc: PWY-7234|UniPathway: UPA00074 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 SMART SM01001 7 157 6.7E-95 T 21-04-2016 IPR000031 Phosphoribosylaminoimidazole carboxylase PurE domain GO:0006189 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 Pfam PF00731 AIR carboxylase 9 155 1.4E-66 T 21-04-2016 IPR000031 Phosphoribosylaminoimidazole carboxylase PurE domain GO:0006189 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 TIGRFAM TIGR01162 purE: phosphoribosylaminoimidazole carboxylase, catalytic subunit 9 164 9.8E-66 T 21-04-2016 IPR000031 Phosphoribosylaminoimidazole carboxylase PurE domain GO:0006189 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 PANTHER PTHR11609 1 169 1.2E-83 T 21-04-2016 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 Gene3D G3DSA:3.40.50.7700 3 165 3.2E-73 T 21-04-2016 IPR000031 Phosphoribosylaminoimidazole carboxylase PurE domain GO:0006189 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 SUPERFAMILY SSF52255 8 167 3.4E-65 T 21-04-2016 IPR000031 Phosphoribosylaminoimidazole carboxylase PurE domain GO:0006189 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 Hamap MF_01929 N5-carboxyaminoimidazole ribonucleotide mutase [purE]. 9 161 32.836 T 21-04-2016 IPR000031 Phosphoribosylaminoimidazole carboxylase PurE domain GO:0006189 SPH21_RS15820 fbec321e582158752a28085fee16028a 169 PANTHER PTHR11609:SF5 1 169 1.2E-83 T 21-04-2016 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 PANTHER PTHR12815 568 766 1.2E-66 T 21-04-2016 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 PANTHER PTHR12815 268 549 1.2E-66 T 21-04-2016 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 PANTHER PTHR12815 59 230 1.2E-66 T 21-04-2016 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 Gene3D G3DSA:2.40.160.50 372 732 9.5E-13 T 21-04-2016 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 Pfam PF01103 Surface antigen 570 733 1.0E-24 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 PANTHER PTHR12815:SF13 568 766 1.2E-66 T 21-04-2016 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 PANTHER PTHR12815:SF13 268 549 1.2E-66 T 21-04-2016 SPH21_RS19525 2ea452ca599dad1bebe20c7120bb4745 766 PANTHER PTHR12815:SF13 59 230 1.2E-66 T 21-04-2016 SPH21_RS19645 0c96e91abbbad257743204566febac0d 233 Gene3D G3DSA:1.10.150.20 65 94 9.0E-4 T 21-04-2016 SPH21_RS19645 0c96e91abbbad257743204566febac0d 233 PANTHER PTHR30471 6 233 4.7E-87 T 21-04-2016 SPH21_RS19645 0c96e91abbbad257743204566febac0d 233 Pfam PF04002 RadC-like JAB domain 112 230 5.9E-39 T 21-04-2016 IPR025657 RadC-like JAB domain SPH21_RS19645 0c96e91abbbad257743204566febac0d 233 ProSitePatterns PS01302 Uncharacterized protein family UPF0758 signature. 182 187 - T 21-04-2016 IPR020891 Uncharacterised protein family UPF0758, conserved site SPH21_RS19645 0c96e91abbbad257743204566febac0d 233 TIGRFAM TIGR00608 radc: DNA repair protein RadC 19 232 3.5E-57 T 21-04-2016 IPR001405 RadC protein SPH21_RS19645 0c96e91abbbad257743204566febac0d 233 PANTHER PTHR30471:SF3 6 233 4.7E-87 T 21-04-2016 SPH21_RS19645 0c96e91abbbad257743204566febac0d 233 Gene3D G3DSA:3.40.140.10 110 231 2.3E-41 T 21-04-2016 SPH21_RS15545 9cc082ce3c314872cc81be81a2151739 161 Gene3D G3DSA:2.40.30.100 9 88 9.0E-18 T 21-04-2016 SPH21_RS15545 9cc082ce3c314872cc81be81a2151739 161 Pfam PF13376 Bacteriocin-protection, YdeI or OmpD-Associated 99 150 2.9E-10 T 21-04-2016 SPH21_RS15545 9cc082ce3c314872cc81be81a2151739 161 Pfam PF08922 Domain of unknown function (DUF1905) 9 88 9.5E-18 T 21-04-2016 IPR015018 Protein of unknown function DUF1905 SPH21_RS15545 9cc082ce3c314872cc81be81a2151739 161 SUPERFAMILY SSF141694 10 89 2.38E-14 T 21-04-2016 SPH21_RS22410 d8701a59039e61fa6fe798ad27f26340 267 Gene3D G3DSA:3.40.190.10 26 158 3.6E-52 T 21-04-2016 SPH21_RS22410 d8701a59039e61fa6fe798ad27f26340 267 PANTHER PTHR30429:SF1 1 267 1.5E-126 T 21-04-2016 SPH21_RS22410 d8701a59039e61fa6fe798ad27f26340 267 SUPERFAMILY SSF53850 29 267 2.72E-75 T 21-04-2016 SPH21_RS22410 d8701a59039e61fa6fe798ad27f26340 267 PIRSF PIRSF002854 1 267 2.2E-93 T 21-04-2016 IPR004872 Lipoprotein NlpA family SPH21_RS22410 d8701a59039e61fa6fe798ad27f26340 267 Pfam PF03180 NLPA lipoprotein 29 267 2.6E-90 T 21-04-2016 IPR004872 Lipoprotein NlpA family SPH21_RS22410 d8701a59039e61fa6fe798ad27f26340 267 PANTHER PTHR30429 1 267 1.5E-126 T 21-04-2016 IPR004872 Lipoprotein NlpA family SPH21_RS22410 d8701a59039e61fa6fe798ad27f26340 267 TIGRFAM TIGR00363 TIGR00363: lipoprotein, YaeC family 12 267 1.9E-119 T 21-04-2016 IPR004872 Lipoprotein NlpA family SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 TIGRFAM TIGR00110 ilvD: dihydroxy-acid dehydratase 25 563 2.5E-217 T 21-04-2016 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 ProSitePatterns PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 129 139 - T 21-04-2016 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 SUPERFAMILY SSF52016 386 563 1.96E-56 T 21-04-2016 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 PANTHER PTHR21000:SF5 3 564 0.0 T 21-04-2016 SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 Pfam PF00920 Dehydratase family 41 560 3.6E-212 T 21-04-2016 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 ProSitePatterns PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 471 482 - T 21-04-2016 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 PANTHER PTHR21000 3 564 0.0 T 21-04-2016 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 Hamap MF_00012 Dihydroxy-acid dehydratase [ilvD]. 11 563 41.821 T 21-04-2016 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11280 95ec1bb0455a826a0d50c07ededd9fde 564 SUPERFAMILY SSF143975 4 384 1.09E-136 T 21-04-2016 SPH21_RS16985 f74d2f18d94e817eac4fa67948f0bbdb 178 SUPERFAMILY SSF56784 3 172 6.53E-29 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS16985 f74d2f18d94e817eac4fa67948f0bbdb 178 PANTHER PTHR16504:SF7 1 153 5.1E-27 T 21-04-2016 SPH21_RS16985 f74d2f18d94e817eac4fa67948f0bbdb 178 Gene3D G3DSA:3.40.50.1000 51 173 3.3E-44 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS16985 f74d2f18d94e817eac4fa67948f0bbdb 178 PANTHER PTHR16504 1 153 5.1E-27 T 21-04-2016 SPH21_RS16985 f74d2f18d94e817eac4fa67948f0bbdb 178 Pfam PF06941 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) 6 172 6.4E-41 T 21-04-2016 IPR010708 5'(3')-deoxyribonucleotidase GO:0008253|GO:0009264 KEGG: 00051+3.1.3.-|KEGG: 00332+3.1.3.-|KEGG: 00565+3.1.3.-|KEGG: 00600+3.1.3.-|KEGG: 00730+3.1.3.-|KEGG: 00740+3.1.3.-|KEGG: 00760+3.1.3.-|Reactome: REACT_1698 SPH21_RS19715 6aba66ddcfe73a5937d6ae7ecb19429b 542 PANTHER PTHR11814 14 539 3.1E-189 T 21-04-2016 IPR001902 SLC26A/SulP transporter GO:0008271|GO:0008272|GO:0016020|GO:0055085 Reactome: REACT_15518 SPH21_RS19715 6aba66ddcfe73a5937d6ae7ecb19429b 542 PANTHER PTHR11814:SF123 14 539 3.1E-189 T 21-04-2016 SPH21_RS19715 6aba66ddcfe73a5937d6ae7ecb19429b 542 Pfam PF00916 Sulfate permease family 17 386 1.4E-60 T 21-04-2016 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 SPH21_RS19715 6aba66ddcfe73a5937d6ae7ecb19429b 542 Gene3D G3DSA:3.30.750.24 445 525 8.6E-5 T 21-04-2016 IPR002645 STAS domain SPH21_RS07970 d548695062cf6d0a4d667b76cfc1a7b9 154 Gene3D G3DSA:3.30.300.70 2 77 1.6E-16 T 21-04-2016 IPR028989 Ribosome maturation factor RimP, N-terminal SPH21_RS07970 d548695062cf6d0a4d667b76cfc1a7b9 154 PANTHER PTHR33867:SF1 1 153 6.2E-33 T 21-04-2016 SPH21_RS07970 d548695062cf6d0a4d667b76cfc1a7b9 154 Pfam PF02576 Putative ribosome maturation factor RimP 15 144 2.5E-26 T 21-04-2016 IPR003728 Ribosome maturation factor RimP GO:0042274 SPH21_RS07970 d548695062cf6d0a4d667b76cfc1a7b9 154 SUPERFAMILY SSF75420 3 80 4.32E-18 T 21-04-2016 IPR028989 Ribosome maturation factor RimP, N-terminal SPH21_RS07970 d548695062cf6d0a4d667b76cfc1a7b9 154 PANTHER PTHR33867 1 153 6.2E-33 T 21-04-2016 SPH21_RS07970 d548695062cf6d0a4d667b76cfc1a7b9 154 Hamap MF_01077 Ribosome maturation factor RimP [rimP]. 5 153 19.163 T 21-04-2016 IPR003728 Ribosome maturation factor RimP GO:0042274 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 Gene3D G3DSA:3.50.50.60 113 303 1.2E-36 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PANTHER PTHR22912:SF48 1 318 4.5E-152 T 21-04-2016 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PANTHER PTHR22912 1 318 4.5E-152 T 21-04-2016 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 42 57 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 198 214 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 131 143 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 63 73 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 237 258 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 109 117 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 146 170 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 272 290 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 9 31 3.0E-75 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 Gene3D G3DSA:3.50.50.60 6 112 5.6E-33 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 TIGRFAM TIGR01292 TRX_reduct: thioredoxin-disulfide reductase 9 309 7.6E-118 T 21-04-2016 IPR005982 Thioredoxin reductase GO:0004791|GO:0005737|GO:0019430|GO:0055114 KEGG: 00240+1.8.1.9|KEGG: 00450+1.8.1.9 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 9 298 5.8E-49 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 SUPERFAMILY SSF51905 3 309 6.24E-53 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 10 29 4.9E-38 T 21-04-2016 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 235 251 4.9E-38 T 21-04-2016 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 108 126 4.9E-38 T 21-04-2016 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 262 284 4.9E-38 T 21-04-2016 SPH21_RS16365 3b9dd0607edb9a28f6e36aa3e3ecddf9 321 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 150 168 4.9E-38 T 21-04-2016 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 131 139 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 321 335 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 151 164 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 227 240 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 355 366 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 414 427 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 165 180 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 108 121 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PRINTS PR00415 Aconitase family signature 241 254 7.8E-39 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PANTHER PTHR11670 12 757 0.0 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 Gene3D G3DSA:3.20.19.10 535 753 1.7E-79 T 21-04-2016 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 Gene3D G3DSA:3.30.499.10 10 196 2.5E-71 T 21-04-2016 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 PANTHER PTHR11670:SF30 12 757 0.0 T 21-04-2016 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 Pfam PF00330 Aconitase family (aconitate hydratase) 34 477 8.3E-157 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 ProSitePatterns PS00450 Aconitase family signature 1. 351 367 - T 21-04-2016 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 Gene3D G3DSA:3.30.499.10 317 489 3.0E-59 T 21-04-2016 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 Gene3D G3DSA:3.40.1060.10 198 316 6.4E-39 T 21-04-2016 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 SUPERFAMILY SSF53732 5 524 8.24E-161 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 Pfam PF00694 Aconitase C-terminal domain 558 685 5.1E-40 T 21-04-2016 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 SUPERFAMILY SSF52016 532 752 5.49E-62 T 21-04-2016 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 ProSitePatterns PS01244 Aconitase family signature 2. 414 427 - T 21-04-2016 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11010 43afb8e6db268cc931d80e35ec9a65b4 757 TIGRFAM TIGR01340 aconitase_mito: aconitate hydratase, mitochondrial 15 749 0.0 T 21-04-2016 IPR006248 Aconitase, mitochondrial-like GO:0003994|GO:0006099|GO:0051539 SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 SUPERFAMILY SSF52096 43 221 3.42E-61 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 Pfam PF00574 Clp protease 47 221 5.1E-73 T 21-04-2016 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 Gene3D G3DSA:3.90.226.10 47 221 9.2E-71 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 PANTHER PTHR10381:SF22 26 220 1.8E-97 T 21-04-2016 SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 PANTHER PTHR10381 26 220 1.8E-97 T 21-04-2016 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 PRINTS PR00127 Clp protease catalytic subunit P signature 198 217 8.9E-44 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 PRINTS PR00127 Clp protease catalytic subunit P signature 141 160 8.9E-44 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 PRINTS PR00127 Clp protease catalytic subunit P signature 120 137 8.9E-44 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 PRINTS PR00127 Clp protease catalytic subunit P signature 49 64 8.9E-44 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 PRINTS PR00127 Clp protease catalytic subunit P signature 89 109 8.9E-44 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS13995 af623f3359b3bd3fee65e3dff2395c24 225 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 33 223 38.184 T 21-04-2016 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SPH21_RS21325 c342958e1078889baeea94fa32a7bb03 495 Pfam PF14322 Starch-binding associating with outer membrane 22 225 1.7E-21 T 21-04-2016 SPH21_RS21325 c342958e1078889baeea94fa32a7bb03 495 Gene3D G3DSA:1.25.40.10 206 436 1.0E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21325 c342958e1078889baeea94fa32a7bb03 495 Pfam PF07980 SusD family 266 495 3.6E-24 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS21325 c342958e1078889baeea94fa32a7bb03 495 SUPERFAMILY SSF48452 18 495 3.03E-103 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 SUPERFAMILY SSF56436 249 366 7.85E-54 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 SUPERFAMILY SSF56436 57 175 7.85E-54 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 SUPERFAMILY SSF56436 443 491 7.85E-54 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 Gene3D G3DSA:3.90.1580.10 47 175 8.3E-87 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 Gene3D G3DSA:3.90.1580.10 449 497 8.3E-87 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 Gene3D G3DSA:3.90.1580.10 249 377 8.3E-87 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 PANTHER PTHR23150 58 178 2.0E-30 T 21-04-2016 SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 PANTHER PTHR23150 255 374 2.0E-30 T 21-04-2016 SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 PANTHER PTHR23150 453 498 2.0E-30 T 21-04-2016 SPH21_RS08080 605525275561052dac77a3eed9f8a770 523 Pfam PF03781 Sulfatase-modifying factor enzyme 1 59 363 3.3E-35 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS16270 9243fe34a12d89a7e015e136f56bc5bc 437 Gene3D G3DSA:1.25.40.10 316 394 4.0E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16270 9243fe34a12d89a7e015e136f56bc5bc 437 Pfam PF14322 Starch-binding associating with outer membrane 38 228 3.5E-12 T 21-04-2016 SPH21_RS16270 9243fe34a12d89a7e015e136f56bc5bc 437 Pfam PF07980 SusD family 320 428 8.7E-5 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS16270 9243fe34a12d89a7e015e136f56bc5bc 437 SUPERFAMILY SSF48452 25 431 1.75E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 Gene3D G3DSA:1.10.390.10 320 424 7.8E-4 T 21-04-2016 SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 Pfam PF13180 PDZ domain 492 572 7.6E-10 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 Pfam PF05299 M61 glycyl aminopeptidase 286 402 5.7E-48 T 21-04-2016 IPR007963 Peptidase M61, catalytic domain SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 Gene3D G3DSA:2.30.42.10 493 577 1.8E-11 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 SUPERFAMILY SSF50156 502 590 1.46E-10 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 SUPERFAMILY SSF55486 205 460 8.79E-17 T 21-04-2016 SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 PIRSF PIRSF016493 25 601 6.3E-183 T 21-04-2016 IPR024191 Peptidase M61 SPH21_RS00130 aa87fcb53f263a1f04ad93cc6d3bbf37 603 SMART SM00228 476 563 3.1E-7 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS00865 7a82e3e30b0fa12304dfab658a242a56 407 Pfam PF00149 Calcineurin-like phosphoesterase 163 342 4.0E-12 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS00865 7a82e3e30b0fa12304dfab658a242a56 407 SUPERFAMILY SSF56300 161 405 3.21E-33 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS00865 7a82e3e30b0fa12304dfab658a242a56 407 PANTHER PTHR31302 4 407 2.3E-60 T 21-04-2016 SPH21_RS00865 7a82e3e30b0fa12304dfab658a242a56 407 Gene3D G3DSA:3.60.21.10 162 349 3.2E-25 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS00865 7a82e3e30b0fa12304dfab658a242a56 407 PANTHER PTHR31302:SF6 4 407 2.3E-60 T 21-04-2016 SPH21_RS19200 2c5fbb7a6f0702e95b9e16976dab815d 277 PANTHER PTHR30269 4 277 6.1E-101 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS19200 2c5fbb7a6f0702e95b9e16976dab815d 277 PANTHER PTHR30269:SF23 4 277 6.1E-101 T 21-04-2016 SPH21_RS19200 2c5fbb7a6f0702e95b9e16976dab815d 277 Pfam PF01925 Sulfite exporter TauE/SafE 11 268 1.0E-46 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 Gene3D G3DSA:1.20.1560.10 3 325 1.7E-47 T 21-04-2016 SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 SUPERFAMILY SSF90123 4 330 5.23E-51 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 SUPERFAMILY SSF52540 340 580 4.33E-81 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 Pfam PF00664 ABC transporter transmembrane region 16 298 7.8E-29 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 ProSitePatterns PS00211 ABC transporters family signature. 480 494 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 PANTHER PTHR24221:SF138 1 589 2.3E-156 T 21-04-2016 SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 SMART SM00382 368 556 5.7E-17 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 PANTHER PTHR24221 1 589 2.3E-156 T 21-04-2016 SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 Gene3D G3DSA:3.40.50.300 343 589 2.2E-75 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02650 648cbff49b239aef11f6bf2367332c09 593 Pfam PF00005 ABC transporter 359 508 4.5E-35 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS04140 59c7c0b9391e075e5c6f2543afc53030 391 Pfam PF16344 Domain of unknown function (DUF4974) 287 384 9.3E-20 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS04140 59c7c0b9391e075e5c6f2543afc53030 391 PANTHER PTHR30273 186 391 9.3E-53 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS04140 59c7c0b9391e075e5c6f2543afc53030 391 PANTHER PTHR30273 1 128 9.3E-53 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS04140 59c7c0b9391e075e5c6f2543afc53030 391 PANTHER PTHR30273:SF2 186 391 9.3E-53 T 21-04-2016 SPH21_RS04140 59c7c0b9391e075e5c6f2543afc53030 391 PANTHER PTHR30273:SF2 1 128 9.3E-53 T 21-04-2016 SPH21_RS04140 59c7c0b9391e075e5c6f2543afc53030 391 Pfam PF04773 FecR protein 185 277 1.0E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 181 3.7E-24 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 Pfam PF04542 Sigma-70 region 2 28 91 1.7E-4 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 PANTHER PTHR30173 1 191 1.1E-41 T 21-04-2016 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 SUPERFAMILY SSF88659 111 188 1.79E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 Gene3D G3DSA:1.10.1740.10 4 95 2.7E-16 T 21-04-2016 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 Gene3D G3DSA:1.10.10.10 120 185 4.3E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 167 179 1.4E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 167 1.4E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 Pfam PF08281 Sigma-70, region 4 128 179 5.7E-16 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 SUPERFAMILY SSF88946 3 93 4.71E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 PANTHER PTHR30173:SF20 1 191 1.1E-41 T 21-04-2016 SPH21_RS06295 812c118d5b04668d554eb150d8fff0f2 203 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 23 183 1.9E-38 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 Pfam PF08281 Sigma-70, region 4 115 167 1.0E-12 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 Gene3D G3DSA:1.10.10.10 109 172 8.6E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 167 3.9E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 139 155 3.9E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 SUPERFAMILY SSF88946 10 96 3.92E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 16 170 1.2E-25 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 PANTHER PTHR30173:SF20 11 181 1.3E-35 T 21-04-2016 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 15 170 3.3E-40 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 Gene3D G3DSA:1.10.1740.10 8 98 8.5E-17 T 21-04-2016 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 SUPERFAMILY SSF88659 96 172 2.62E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 Pfam PF04542 Sigma-70 region 2 20 85 7.8E-10 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09700 2f71f0c8521c8c864f113e99110cb1b0 186 PANTHER PTHR30173 11 181 1.3E-35 T 21-04-2016 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 Gene3D G3DSA:3.40.718.10 1 311 9.2E-103 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 PIRSF PIRSF002465 1 312 1.1E-95 T 21-04-2016 IPR012281 Phospholipid biosynthesis protein, PlsX-like GO:0006633 UniPathway: UPA00085 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 PANTHER PTHR30100:SF1 1 312 5.3E-100 T 21-04-2016 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 Hamap MF_00019 Phosphate acyltransferase [plsX]. 1 312 108.482 T 21-04-2016 IPR012281 Phospholipid biosynthesis protein, PlsX-like GO:0006633 UniPathway: UPA00085 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 Pfam PF02504 Fatty acid synthesis protein 255 304 1.3E-7 T 21-04-2016 IPR003664 Fatty acid synthesis PlsX protein GO:0003824|GO:0006633|GO:0016747 UniPathway: UPA00085 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 Pfam PF02504 Fatty acid synthesis protein 1 244 7.4E-80 T 21-04-2016 IPR003664 Fatty acid synthesis PlsX protein GO:0003824|GO:0006633|GO:0016747 UniPathway: UPA00085 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 SUPERFAMILY SSF53659 1 311 9.46E-76 T 21-04-2016 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 PANTHER PTHR30100 1 312 5.3E-100 T 21-04-2016 SPH21_RS00050 1b425e2dace0eeb939a2ea765792191a 312 TIGRFAM TIGR00182 plsX: fatty acid/phospholipid synthesis protein PlsX 1 244 4.1E-76 T 21-04-2016 IPR012281 Phospholipid biosynthesis protein, PlsX-like GO:0006633 UniPathway: UPA00085 SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 8.58E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 121 137 8.58E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 147 166 8.58E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 8.58E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 170 187 8.58E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PANTHER PTHR24322:SF57 8 131 1.6E-23 T 21-04-2016 SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PANTHER PTHR24322:SF57 147 181 1.6E-23 T 21-04-2016 SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 SUPERFAMILY SSF51735 1 238 8.54E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 Gene3D G3DSA:3.40.50.720 2 236 7.4E-36 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PANTHER PTHR24322 8 131 1.6E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 PANTHER PTHR24322 147 181 1.6E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21090 2dbc28a7ad6fe09137ccf2b90f5bdfb2 240 Pfam PF00106 short chain dehydrogenase 4 189 5.6E-32 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS09590 d1d9e6ebc07bd2aea3827280b35e8ed5 484 PIRSF PIRSF016636 1 484 2.2E-152 T 21-04-2016 IPR024194 Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB SPH21_RS09590 d1d9e6ebc07bd2aea3827280b35e8ed5 484 PIRSF PIRSF500217 1 484 7.0E-154 T 21-04-2016 IPR028362 Alginate O-acetyltransferase AlgI GO:0042121 KEGG: 00061+2.3.1.-|KEGG: 00253+2.3.1.-|KEGG: 00261+2.3.1.-|KEGG: 00310+2.3.1.-|KEGG: 00330+2.3.1.-|KEGG: 00332+2.3.1.-|KEGG: 00340+2.3.1.-|KEGG: 00350+2.3.1.-|KEGG: 00564+2.3.1.-|KEGG: 00565+2.3.1.-|KEGG: 00604+2.3.1.-|KEGG: 00623+2.3.1.-|KEGG: 00626+2.3.1.-|KEGG: 00627+2.3.1.-|KEGG: 00642+2.3.1.-|KEGG: 00650+2.3.1.-|KEGG: 00680+2.3.1.-|KEGG: 00903+2.3.1.-|KEGG: 00904+2.3.1.-|KEGG: 00906+2.3.1.-|KEGG: 00940+2.3.1.-|KEGG: 00942+2.3.1.-|KEGG: 00950+2.3.1.-|KEGG: 00960+2.3.1.-|KEGG: 00965+2.3.1.-|UniPathway: UPA00286 SPH21_RS09590 d1d9e6ebc07bd2aea3827280b35e8ed5 484 PANTHER PTHR13285:SF24 1 448 4.0E-126 T 21-04-2016 SPH21_RS09590 d1d9e6ebc07bd2aea3827280b35e8ed5 484 Pfam PF03062 MBOAT, membrane-bound O-acyltransferase family 152 351 3.4E-23 T 21-04-2016 IPR004299 Membrane bound O-acyl transferase, MBOAT SPH21_RS09590 d1d9e6ebc07bd2aea3827280b35e8ed5 484 PANTHER PTHR13285 1 448 4.0E-126 T 21-04-2016 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 177 8.1E-6 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 149 165 8.1E-6 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 PANTHER PTHR30173:SF20 2 182 1.1E-29 T 21-04-2016 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 Pfam PF08281 Sigma-70, region 4 126 177 7.4E-15 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 SUPERFAMILY SSF88659 110 183 1.11E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 SUPERFAMILY SSF88946 17 107 1.69E-8 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 Gene3D G3DSA:1.10.1740.10 26 106 1.7E-6 T 21-04-2016 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 29 179 2.2E-21 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 PANTHER PTHR30173 2 182 1.1E-29 T 21-04-2016 SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 Gene3D G3DSA:1.10.10.10 120 183 1.2E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13750 5431752a9b0d43751ce7ca9ad2483fb4 188 ProSitePatterns PS00622 LuxR-type HTH domain signature. 149 176 - T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS20185 7feec762992c8fbf5fbb4e9d16f9afea 234 PANTHER PTHR38011:SF2 31 215 4.8E-28 T 21-04-2016 SPH21_RS20185 7feec762992c8fbf5fbb4e9d16f9afea 234 SUPERFAMILY SSF53597 32 211 3.53E-29 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS20185 7feec762992c8fbf5fbb4e9d16f9afea 234 PANTHER PTHR38011 31 215 4.8E-28 T 21-04-2016 SPH21_RS20185 7feec762992c8fbf5fbb4e9d16f9afea 234 Pfam PF01872 RibD C-terminal domain 32 207 1.1E-23 T 21-04-2016 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SPH21_RS20185 7feec762992c8fbf5fbb4e9d16f9afea 234 Gene3D G3DSA:3.40.430.10 32 211 6.7E-26 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS21695 037b3fd3a775592fd990ef4aac06294d 209 PANTHER PTHR23026:SF101 1 203 9.7E-39 T 21-04-2016 SPH21_RS21695 037b3fd3a775592fd990ef4aac06294d 209 SUPERFAMILY SSF55469 1 206 6.41E-46 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS21695 037b3fd3a775592fd990ef4aac06294d 209 PANTHER PTHR23026 1 203 9.7E-39 T 21-04-2016 SPH21_RS21695 037b3fd3a775592fd990ef4aac06294d 209 Gene3D G3DSA:3.40.109.10 1 207 1.1E-55 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS21695 037b3fd3a775592fd990ef4aac06294d 209 Pfam PF00881 Nitroreductase family 8 183 6.4E-24 T 21-04-2016 IPR029479 Nitroreductase SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 Gene3D G3DSA:2.40.50.100 20 84 4.1E-32 T 21-04-2016 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 PANTHER PTHR15893 1 85 9.2E-47 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 ProDom PD003114 RIBOSOMAL L27 50S RIBONUCLEOPROTEIN CHLOROPLAST MITOCHONDRIAL PEPTIDE 60S TRANSIT PRECURSOR 28 83 2.0E-16 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 Pfam PF01016 Ribosomal L27 protein 2 81 7.5E-37 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 SUPERFAMILY SSF110324 2 83 3.38E-34 T 21-04-2016 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 Hamap MF_00539 50S ribosomal protein L27 [rpmA]. 1 84 28.155 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 TIGRFAM TIGR00062 L27: ribosomal protein bL27 1 81 1.5E-35 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 PRINTS PR00063 Ribosomal protein L27 signature 54 78 3.9E-36 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 PRINTS PR00063 Ribosomal protein L27 signature 29 53 3.9E-36 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16465 cede471b66941013518a6fc0e6e5cd96 90 PRINTS PR00063 Ribosomal protein L27 signature 4 28 3.9E-36 T 21-04-2016 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS09090 dae6bec0a483d29d8c501c5d8e4f6dae 130 Gene3D G3DSA:3.40.50.1010 4 130 1.6E-33 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS09090 dae6bec0a483d29d8c501c5d8e4f6dae 130 PANTHER PTHR33653 5 130 1.6E-26 T 21-04-2016 SPH21_RS09090 dae6bec0a483d29d8c501c5d8e4f6dae 130 Pfam PF01850 PIN domain 7 123 1.0E-16 T 21-04-2016 IPR002716 PIN domain SPH21_RS09090 dae6bec0a483d29d8c501c5d8e4f6dae 130 PANTHER PTHR33653:SF2 5 130 1.6E-26 T 21-04-2016 SPH21_RS09090 dae6bec0a483d29d8c501c5d8e4f6dae 130 SMART SM00670 4 121 1.4E-5 T 21-04-2016 IPR002716 PIN domain SPH21_RS09090 dae6bec0a483d29d8c501c5d8e4f6dae 130 SUPERFAMILY SSF88723 5 130 5.33E-30 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS09090 dae6bec0a483d29d8c501c5d8e4f6dae 130 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC]. 6 128 9.589 T 21-04-2016 IPR022907 VapC family GO:0004540 SPH21_RS11795 3004ec9252c985df1b0331e4c9753aef 714 Gene3D G3DSA:2.60.40.10 208 285 5.0E-8 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS11795 3004ec9252c985df1b0331e4c9753aef 714 Pfam PF10091 Putative glucoamylase 540 703 3.1E-22 T 21-04-2016 IPR019282 Domain of unknown function DUF2329 SPH21_RS23510 473eb70f1ebffa309f01866d80396468 153 PANTHER PTHR33570:SF5 36 153 1.9E-33 T 21-04-2016 SPH21_RS23510 473eb70f1ebffa309f01866d80396468 153 Gene3D G3DSA:2.60.120.10 33 150 4.3E-25 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS23510 473eb70f1ebffa309f01866d80396468 153 Pfam PF07883 Cupin domain 62 120 5.9E-10 T 21-04-2016 IPR013096 Cupin 2, conserved barrel SPH21_RS23510 473eb70f1ebffa309f01866d80396468 153 PANTHER PTHR33570 36 153 1.9E-33 T 21-04-2016 SPH21_RS23510 473eb70f1ebffa309f01866d80396468 153 SUPERFAMILY SSF51182 30 150 1.6E-26 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS07150 e2aa69cf2dc74e7ee05010d04898e7d5 428 Gene3D G3DSA:1.20.1250.20 6 183 8.6E-19 T 21-04-2016 SPH21_RS07150 e2aa69cf2dc74e7ee05010d04898e7d5 428 Gene3D G3DSA:1.20.1250.20 390 417 8.3E-9 T 21-04-2016 SPH21_RS07150 e2aa69cf2dc74e7ee05010d04898e7d5 428 Gene3D G3DSA:1.20.1250.20 206 352 8.3E-9 T 21-04-2016 SPH21_RS07150 e2aa69cf2dc74e7ee05010d04898e7d5 428 PANTHER PTHR23514 1 403 1.7E-20 T 21-04-2016 SPH21_RS07150 e2aa69cf2dc74e7ee05010d04898e7d5 428 SUPERFAMILY SSF103473 386 417 5.1E-39 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS07150 e2aa69cf2dc74e7ee05010d04898e7d5 428 SUPERFAMILY SSF103473 6 351 5.1E-39 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS07150 e2aa69cf2dc74e7ee05010d04898e7d5 428 Pfam PF07690 Major Facilitator Superfamily 15 333 3.7E-20 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 SUPERFAMILY SSF52172 1 180 4.55E-36 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 PANTHER PTHR26402:SF545 1 224 1.2E-86 T 21-04-2016 SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 SMART SM00862 145 222 3.4E-17 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 Gene3D G3DSA:1.10.10.10 126 224 1.5E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 Pfam PF00072 Response regulator receiver domain 3 113 1.7E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 Gene3D G3DSA:3.40.50.2300 1 125 2.3E-35 T 21-04-2016 SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 Pfam PF00486 Transcriptional regulatory protein, C terminal 145 222 4.0E-17 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 SMART SM00448 1 112 1.7E-37 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS12685 f7a00a4c907f0f3b4b0ede1437d4c473 225 PANTHER PTHR26402 1 224 1.2E-86 T 21-04-2016 SPH21_RS22615 731429eea34a4aa51789570c4d3beecc 207 PANTHER PTHR30246:SF4 1 206 8.9E-68 T 21-04-2016 SPH21_RS22615 731429eea34a4aa51789570c4d3beecc 207 SUPERFAMILY SSF51569 2 203 2.75E-58 T 21-04-2016 SPH21_RS22615 731429eea34a4aa51789570c4d3beecc 207 PANTHER PTHR30246 1 206 8.9E-68 T 21-04-2016 SPH21_RS22615 731429eea34a4aa51789570c4d3beecc 207 Pfam PF01081 KDPG and KHG aldolase 5 183 5.9E-40 T 21-04-2016 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SPH21_RS22615 731429eea34a4aa51789570c4d3beecc 207 Gene3D G3DSA:3.20.20.70 2 206 6.3E-69 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS22615 731429eea34a4aa51789570c4d3beecc 207 TIGRFAM TIGR01182 eda: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase 5 203 1.4E-48 T 21-04-2016 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 SUPERFAMILY SSF53335 37 297 2.78E-46 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 PANTHER PTHR22807:SF36 30 349 3.0E-96 T 21-04-2016 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 Gene3D G3DSA:3.40.50.150 86 297 3.0E-46 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 74 88 4.6E-26 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 107 117 4.6E-26 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 173 185 4.6E-26 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 223 239 4.6E-26 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 279 296 4.6E-26 T 21-04-2016 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 Pfam PF13636 RNA-binding PUA-like domain of methyltransferase RsmF 400 448 1.2E-19 T 21-04-2016 IPR027391 rRNA small subunit methyltransferase F, RNA-binding PUA-like domain KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 Pfam PF17125 N-terminal domain of 16S rRNA methyltransferase RsmF 5 88 3.1E-19 T 21-04-2016 IPR031341 Ribosomal RNA small subunit methyltransferase F, N-terminal KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 Pfam PF01189 16S rRNA methyltransferase RsmB/F 104 294 7.9E-41 T 21-04-2016 IPR001678 SAM-dependent methyltransferase RsmB/NOP2-type GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS02850 f0c42bc2c33fc76e7de160d84cc6e7f3 451 PANTHER PTHR22807 30 349 3.0E-96 T 21-04-2016 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 SUPERFAMILY SSF52507 1 179 4.58E-60 T 21-04-2016 IPR003382 Flavoprotein GO:0003824 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 Pfam PF02441 Flavoprotein 5 133 3.8E-35 T 21-04-2016 IPR003382 Flavoprotein GO:0003824 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 TIGRFAM TIGR00521 coaBC_dfp: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase 2 399 9.0E-131 T 21-04-2016 IPR005252 Coenzyme A biosynthesis bifunctional protein CoaBC GO:0004632|GO:0004633|GO:0010181|GO:0015937|GO:0015941 KEGG: 00770+4.1.1.36+6.3.2.5|UniPathway: UPA00241|UniPathway: UPA00241 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 PANTHER PTHR14359 1 402 1.4E-180 T 21-04-2016 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 SUPERFAMILY SSF102645 188 402 9.16E-75 T 21-04-2016 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|UniPathway: UPA00241 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 Pfam PF04127 DNA / pantothenate metabolism flavoprotein 190 373 4.6E-72 T 21-04-2016 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|UniPathway: UPA00241 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 Gene3D G3DSA:3.40.50.1950 2 183 4.9E-64 T 21-04-2016 IPR003382 Flavoprotein GO:0003824 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 Gene3D G3DSA:3.40.50.10300 187 402 8.2E-84 T 21-04-2016 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|UniPathway: UPA00241 SPH21_RS08720 2ed08070285433883fe09f9591444364 406 PANTHER PTHR14359:SF20 1 402 1.4E-180 T 21-04-2016 SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 SUPERFAMILY SSF54826 1 121 6.22E-24 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 Gene3D G3DSA:3.20.20.120 122 350 9.3E-68 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 PANTHER PTHR13794:SF55 1 365 2.3E-101 T 21-04-2016 SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 SUPERFAMILY SSF51604 110 360 1.17E-64 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 Gene3D G3DSA:3.30.390.10 1 121 8.1E-28 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 9 120 3.2E-13 T 21-04-2016 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 PANTHER PTHR13794 1 365 2.3E-101 T 21-04-2016 IPR001354 Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase GO:0003824|GO:0008152 SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 SMART SM00922 139 235 9.8E-22 T 21-04-2016 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SPH21_RS17630 66fc7ebefb508247f17fc60bdc24876e 365 Pfam PF13378 Enolase C-terminal domain-like 142 354 6.2E-49 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 PANTHER PTHR11552 91 558 3.2E-51 T 21-04-2016 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 PANTHER PTHR11552 3 71 3.2E-51 T 21-04-2016 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 Pfam PF05199 GMC oxidoreductase 423 546 4.0E-21 T 21-04-2016 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 Pfam PF00732 GMC oxidoreductase 70 311 2.2E-11 T 21-04-2016 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 Gene3D G3DSA:3.50.50.60 2 156 1.1E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 Gene3D G3DSA:3.50.50.60 485 552 1.1E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 Gene3D G3DSA:3.50.50.60 226 334 1.1E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 Gene3D G3DSA:3.50.50.60 433 446 1.1E-69 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 SUPERFAMILY SSF54373 348 495 3.92E-46 T 21-04-2016 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 PANTHER PTHR11552:SF139 91 558 3.2E-51 T 21-04-2016 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 PANTHER PTHR11552:SF139 3 71 3.2E-51 T 21-04-2016 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 SUPERFAMILY SSF51905 494 555 2.46E-60 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 SUPERFAMILY SSF51905 1 69 2.46E-60 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS00860 b64b91ed5d0f3ada5b7336a0ab7dd3b9 559 SUPERFAMILY SSF51905 96 335 2.46E-60 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 55 4.5E-12 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 PANTHER PTHR30055 2 192 6.0E-50 T 21-04-2016 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 Gene3D G3DSA:1.10.10.60 2 64 1.0E-19 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 SUPERFAMILY SSF48498 78 191 2.28E-22 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 Gene3D G3DSA:1.10.357.10 68 192 1.5E-22 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 PANTHER PTHR30055:SF44 2 192 6.0E-50 T 21-04-2016 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 SUPERFAMILY SSF46689 5 78 1.85E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 1.3E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS21580 685781e3abea464e2badd3b74c7de02a 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 1.3E-5 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 Gene3D G3DSA:3.30.870.10 315 483 1.0E-57 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 Pfam PF13090 Polyphosphate kinase C-terminal domain 320 667 3.1E-134 T 21-04-2016 IPR025200 Polyphosphate kinase C-terminal domain KEGG: 00190+2.7.4.1 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 SUPERFAMILY SSF56024 495 667 1.59E-60 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 PANTHER PTHR30218 12 657 2.9E-208 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 SUPERFAMILY SSF143724 112 297 2.55E-30 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 TIGRFAM TIGR03705 poly_P_kin: polyphosphate kinase 1 10 662 1.0E-189 T 21-04-2016 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 PANTHER PTHR30218:SF0 12 657 2.9E-208 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 Gene3D G3DSA:3.30.870.10 493 670 2.2E-65 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 Gene3D G3DSA:1.20.58.310 4 108 1.7E-28 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 SUPERFAMILY SSF140356 7 108 1.31E-25 T 21-04-2016 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 Pfam PF02503 Polyphosphate kinase middle domain 126 309 3.7E-29 T 21-04-2016 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 PIRSF PIRSF015589 1 678 4.2E-202 T 21-04-2016 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 SUPERFAMILY SSF56024 314 483 1.19E-43 T 21-04-2016 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 Pfam PF13089 Polyphosphate kinase N-terminal domain 11 115 7.8E-30 T 21-04-2016 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 SPH21_RS02625 1f6491b1b39e2839460b839c88b3156a 681 Gene3D G3DSA:3.30.1840.10 111 294 1.6E-30 T 21-04-2016 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 SPH21_RS19665 c6e0337b7cb7207bd2f6acf40ba8229d 624 PANTHER PTHR32552 34 624 3.4E-30 T 21-04-2016 SPH21_RS19665 c6e0337b7cb7207bd2f6acf40ba8229d 624 Pfam PF07715 TonB-dependent Receptor Plug Domain 52 155 9.3E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19665 c6e0337b7cb7207bd2f6acf40ba8229d 624 Gene3D G3DSA:2.170.130.10 31 161 8.7E-30 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19665 c6e0337b7cb7207bd2f6acf40ba8229d 624 Pfam PF00593 TonB dependent receptor 396 622 4.1E-24 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19665 c6e0337b7cb7207bd2f6acf40ba8229d 624 SUPERFAMILY SSF56935 42 624 4.81E-88 T 21-04-2016 SPH21_RS19665 c6e0337b7cb7207bd2f6acf40ba8229d 624 Gene3D G3DSA:2.40.170.20 162 624 3.7E-60 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19665 c6e0337b7cb7207bd2f6acf40ba8229d 624 PANTHER PTHR32552:SF0 34 624 3.4E-30 T 21-04-2016 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 Gene3D G3DSA:3.10.50.30 77 156 1.4E-25 T 21-04-2016 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 SUPERFAMILY SSF54534 85 155 2.35E-18 T 21-04-2016 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 ProSitePatterns PS00830 Prokaryotic transcription elongation factors signature 2. 121 137 - T 21-04-2016 IPR018151 Transcription elongation factor, GreA/GreB, conserved site GO:0003677|GO:0032784 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 PIRSF PIRSF006092 1 157 1.0E-48 T 21-04-2016 IPR023459 Transcription elongation factor GreA/GreB family GO:0070063 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 PANTHER PTHR30437 1 155 3.0E-51 T 21-04-2016 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 Gene3D G3DSA:1.10.287.180 4 76 6.3E-27 T 21-04-2016 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 SUPERFAMILY SSF46557 4 79 5.89E-24 T 21-04-2016 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 Pfam PF03449 Transcription elongation factor, N-terminal 6 74 7.9E-27 T 21-04-2016 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 Hamap MF_00105 Transcription elongation factor GreA [greA]. 3 156 29.682 T 21-04-2016 IPR028624 Transcription elongation factor GreA/GreB GO:0003677|GO:0032784|GO:0070063 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 TIGRFAM TIGR01462 greA: transcription elongation factor GreA 7 156 6.4E-51 T 21-04-2016 IPR006359 Transcription elongation factor GreA GO:0003677|GO:0032784 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term 85 156 1.5E-23 T 21-04-2016 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SPH21_RS07775 d86f5fbf31b91aa688442db99ce54e79 157 ProSitePatterns PS00829 Prokaryotic transcription elongation factors signature 1. 18 49 - T 21-04-2016 IPR018151 Transcription elongation factor, GreA/GreB, conserved site GO:0003677|GO:0032784 SPH21_RS09105 65d7ca92dac7f2c09da7b77043d02a7d 137 Pfam PF02566 OsmC-like protein 41 131 8.0E-19 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS09105 65d7ca92dac7f2c09da7b77043d02a7d 137 PANTHER PTHR33797 1 137 3.9E-41 T 21-04-2016 SPH21_RS09105 65d7ca92dac7f2c09da7b77043d02a7d 137 SUPERFAMILY SSF82784 2 135 1.19E-31 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS09105 65d7ca92dac7f2c09da7b77043d02a7d 137 TIGRFAM TIGR03562 osmo_induc_OsmC: peroxiredoxin, OsmC subfamily 2 132 1.9E-48 T 21-04-2016 IPR019904 Peroxiredoxin OsmC GO:0004601|GO:0006979 KEGG: 00480+1.11.1.15 SPH21_RS09105 65d7ca92dac7f2c09da7b77043d02a7d 137 PANTHER PTHR33797:SF1 1 137 3.9E-41 T 21-04-2016 SPH21_RS09105 65d7ca92dac7f2c09da7b77043d02a7d 137 Gene3D G3DSA:3.30.300.20 1 135 6.4E-44 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 Pfam PF00361 Proton-conducting membrane transporter 124 406 2.0E-64 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 60 111 2.8E-14 T 21-04-2016 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 PANTHER PTHR22773 3 567 6.4E-182 T 21-04-2016 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 Pfam PF13244 Domain of unknown function (DUF4040) 602 667 6.0E-18 T 21-04-2016 IPR025383 Domain of unknown function DUF4040 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 PANTHER PTHR22773:SF85 3 567 6.4E-182 T 21-04-2016 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 73 98 6.6E-38 T 21-04-2016 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 233 259 6.6E-38 T 21-04-2016 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 301 313 6.6E-38 T 21-04-2016 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 211 232 6.6E-38 T 21-04-2016 SPH21_RS14975 483603f04ebfcaec2092e358570404ec 764 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 101 121 6.6E-38 T 21-04-2016 SPH21_RS18430 fe65014be07fb9c418ec1e58e65e1396 278 PANTHER PTHR30535:SF4 22 276 7.2E-65 T 21-04-2016 SPH21_RS18430 fe65014be07fb9c418ec1e58e65e1396 278 Pfam PF01497 Periplasmic binding protein 25 256 3.8E-32 T 21-04-2016 IPR002491 ABC transporter periplasmic binding domain GO:0005488 SPH21_RS18430 fe65014be07fb9c418ec1e58e65e1396 278 SUPERFAMILY SSF53807 22 276 1.9E-50 T 21-04-2016 SPH21_RS18430 fe65014be07fb9c418ec1e58e65e1396 278 Gene3D G3DSA:3.40.50.1980 149 276 5.3E-21 T 21-04-2016 SPH21_RS18430 fe65014be07fb9c418ec1e58e65e1396 278 Gene3D G3DSA:3.40.50.1980 22 141 6.3E-22 T 21-04-2016 SPH21_RS18430 fe65014be07fb9c418ec1e58e65e1396 278 PANTHER PTHR30535 22 276 7.2E-65 T 21-04-2016 SPH21_RS08605 695e1b543d55025fa7b476b73422ba8a 72 SUPERFAMILY SSF50249 1 71 8.36E-28 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS08605 695e1b543d55025fa7b476b73422ba8a 72 Pfam PF01176 Translation initiation factor 1A / IF-1 7 70 6.5E-28 T 21-04-2016 IPR006196 RNA-binding domain, S1, IF1 type GO:0003723|GO:0003743|GO:0006413 SPH21_RS08605 695e1b543d55025fa7b476b73422ba8a 72 Hamap MF_00075 Translation initiation factor IF-1 [infA]. 1 72 27.034 T 21-04-2016 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 SPH21_RS08605 695e1b543d55025fa7b476b73422ba8a 72 SMART SM00316 4 72 3.4E-4 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS08605 695e1b543d55025fa7b476b73422ba8a 72 PANTHER PTHR33370 1 72 1.5E-46 T 21-04-2016 SPH21_RS08605 695e1b543d55025fa7b476b73422ba8a 72 Gene3D G3DSA:2.40.50.140 1 72 6.5E-39 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS08605 695e1b543d55025fa7b476b73422ba8a 72 TIGRFAM TIGR00008 infA: translation initiation factor IF-1 3 71 1.2E-36 T 21-04-2016 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 Gene3D G3DSA:2.40.10.10 146 220 5.9E-17 T 21-04-2016 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 Gene3D G3DSA:2.40.10.10 226 322 2.5E-16 T 21-04-2016 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 PRINTS PR00834 HtrA/DegQ protease family signature 288 305 9.0E-14 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 PRINTS PR00834 HtrA/DegQ protease family signature 192 212 9.0E-14 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 PRINTS PR00834 HtrA/DegQ protease family signature 266 283 9.0E-14 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 PRINTS PR00834 HtrA/DegQ protease family signature 171 183 9.0E-14 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 Pfam PF13365 Trypsin-like peptidase domain 162 295 9.7E-20 T 21-04-2016 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 PANTHER PTHR22939 162 325 1.7E-24 T 21-04-2016 SPH21_RS18010 0ff7acbaa14f4a89213cc90c64e80f37 361 SUPERFAMILY SSF50494 156 322 4.7E-35 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS20780 f73fe635a9cb880705f4431cf5d8023e 104 PANTHER PTHR33204 1 104 7.9E-36 T 21-04-2016 SPH21_RS20780 f73fe635a9cb880705f4431cf5d8023e 104 Gene3D G3DSA:1.10.10.10 2 102 1.3E-36 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20780 f73fe635a9cb880705f4431cf5d8023e 104 SUPERFAMILY SSF46785 6 103 3.66E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20780 f73fe635a9cb880705f4431cf5d8023e 104 Pfam PF01638 HxlR-like helix-turn-helix 20 102 2.9E-28 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PANTHER PTHR24322 11 142 2.4E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PANTHER PTHR24322 158 194 2.4E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 248 1.3E-68 T 21-04-2016 SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 5.6E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 214 234 5.6E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 5.6E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 5.6E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 5.6E-38 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 Gene3D G3DSA:3.40.50.720 2 252 2.4E-85 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 1.5E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 1.5E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 1.5E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS15815 9a9b0bcbf9a17a9968c551385b1fa38c 258 SUPERFAMILY SSF51735 5 252 4.54E-81 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14375 d621ebe58e673f52d255afe3a7bdbca7 633 SUPERFAMILY SSF52317 432 608 1.92E-11 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS14375 d621ebe58e673f52d255afe3a7bdbca7 633 Pfam PF07470 Glycosyl Hydrolase Family 88 28 389 8.6E-103 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS14375 d621ebe58e673f52d255afe3a7bdbca7 633 PANTHER PTHR33886:SF3 2 425 2.5E-167 T 21-04-2016 SPH21_RS14375 d621ebe58e673f52d255afe3a7bdbca7 633 SUPERFAMILY SSF48208 52 388 6.55E-72 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS14375 d621ebe58e673f52d255afe3a7bdbca7 633 PANTHER PTHR33886 2 425 2.5E-167 T 21-04-2016 SPH21_RS14375 d621ebe58e673f52d255afe3a7bdbca7 633 Gene3D G3DSA:1.50.10.10 25 388 5.7E-126 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS01660 e01503bd1c848a7009665052f32c3d79 323 PANTHER PTHR23409 1 323 2.2E-225 T 21-04-2016 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: REACT_1698|UniPathway: UPA00326 SPH21_RS01660 e01503bd1c848a7009665052f32c3d79 323 Pfam PF00268 Ribonucleotide reductase, small chain 15 280 2.0E-121 T 21-04-2016 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: REACT_1698|UniPathway: UPA00326 SPH21_RS01660 e01503bd1c848a7009665052f32c3d79 323 SUPERFAMILY SSF47240 3 305 8.11E-118 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS01660 e01503bd1c848a7009665052f32c3d79 323 Gene3D G3DSA:1.10.620.20 3 288 1.8E-123 T 21-04-2016 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: REACT_1698 SPH21_RS01660 e01503bd1c848a7009665052f32c3d79 323 ProSitePatterns PS00368 Ribonucleotide reductase small subunit signature. 104 120 - T 21-04-2016 IPR030475 Ribonucleotide reductase small subunit, acitve site KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS06980 78ddb506a703c86f78759906617dd2a0 953 Pfam PF07495 Y_Y_Y domain 675 726 6.2E-10 T 21-04-2016 IPR011123 Two component regulator three Y SPH21_RS06980 78ddb506a703c86f78759906617dd2a0 953 SMART SM00421 893 950 0.0074 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS06980 78ddb506a703c86f78759906617dd2a0 953 SUPERFAMILY SSF46894 888 951 1.94E-8 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS06980 78ddb506a703c86f78759906617dd2a0 953 Gene3D G3DSA:1.10.10.10 902 950 1.4E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24650 06e87c7d7ef433a85a7aacb5203d63c5 397 SUPERFAMILY SSF103473 17 395 7.85E-62 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS24650 06e87c7d7ef433a85a7aacb5203d63c5 397 Pfam PF07690 Major Facilitator Superfamily 23 254 6.2E-33 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS24650 06e87c7d7ef433a85a7aacb5203d63c5 397 Gene3D G3DSA:1.20.1250.20 225 395 2.3E-21 T 21-04-2016 SPH21_RS24650 06e87c7d7ef433a85a7aacb5203d63c5 397 PANTHER PTHR23501 16 394 9.1E-59 T 21-04-2016 SPH21_RS24650 06e87c7d7ef433a85a7aacb5203d63c5 397 Gene3D G3DSA:1.20.1250.20 19 190 4.0E-26 T 21-04-2016 SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 SUPERFAMILY SSF63411 261 457 1.83E-40 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 Gene3D G3DSA:3.30.830.10 42 248 8.9E-36 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 SUPERFAMILY SSF63411 24 252 3.19E-42 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 PANTHER PTHR11851 20 456 1.3E-65 T 21-04-2016 SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 Pfam PF00675 Insulinase (Peptidase family M16) 55 169 6.7E-7 T 21-04-2016 IPR011765 Peptidase M16, N-terminal SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 Pfam PF05193 Peptidase M16 inactive domain 199 376 7.0E-32 T 21-04-2016 IPR007863 Peptidase M16, C-terminal SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 Gene3D G3DSA:3.30.830.10 259 444 9.9E-37 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS02560 0fef8aa219b771f1aac5d9cb79492d35 682 PANTHER PTHR11851:SF140 20 456 1.3E-65 T 21-04-2016 SPH21_RS11060 907cd5d04d56c24a40dc89d234b3ba78 470 Pfam PF13520 Amino acid permease 14 443 1.1E-56 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS11060 907cd5d04d56c24a40dc89d234b3ba78 470 PIRSF PIRSF006060 1 469 4.4E-80 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS11060 907cd5d04d56c24a40dc89d234b3ba78 470 PANTHER PTHR11785 1 467 2.0E-106 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 ProSitePatterns PS00177 DNA topoisomerase II signature. 406 414 - T 21-04-2016 IPR018522 DNA topoisomerase, type IIA, conserved site GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 Pfam PF01751 Toprim domain 403 507 5.8E-13 T 21-04-2016 IPR006171 Toprim domain SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 SUPERFAMILY SSF55874 4 201 9.74E-39 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PANTHER PTHR10169:SF28 1 612 6.3E-282 T 21-04-2016 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 Gene3D G3DSA:3.30.565.10 4 202 2.1E-50 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 Pfam PF00204 DNA gyrase B 231 362 4.6E-29 T 21-04-2016 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 37 166 2.5E-10 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 SMART SM00433 38 603 4.6E-147 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 SUPERFAMILY SSF56719 393 602 3.14E-57 T 21-04-2016 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 504 516 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 107 121 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 466 482 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 38 53 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 544 560 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 249 262 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 72 85 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 484 501 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PRINTS PR00418 DNA topoisomerase II family signature 404 418 3.9E-49 T 21-04-2016 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 SUPERFAMILY SSF54211 219 368 7.78E-31 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 PANTHER PTHR10169 1 612 6.3E-282 T 21-04-2016 SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 Gene3D G3DSA:3.30.230.10 206 369 1.8E-43 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 SMART SM00387 34 168 3.2E-5 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08140 3ff3c440984ed8caa8610e18713ca787 626 Gene3D G3DSA:3.40.50.670 370 537 4.6E-60 T 21-04-2016 IPR013759 DNA topoisomerase, type IIA, central domain GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 PANTHER PTHR11019 53 294 4.0E-23 T 21-04-2016 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 Pfam PF12833 Helix-turn-helix domain 217 294 3.6E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 Gene3D G3DSA:1.10.10.60 248 294 5.1E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 262 277 1.6E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 277 293 1.6E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 SMART SM00342 209 293 2.9E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 SUPERFAMILY SSF46689 248 294 1.12E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21730 8cf28e0cc01a88da1714139fc5963f93 295 PANTHER PTHR11019:SF80 53 294 4.0E-23 T 21-04-2016 SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 115 132 - T 21-04-2016 IPR001882 Biotin-binding site SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 PANTHER PTHR23151:SF64 3 158 9.7E-47 T 21-04-2016 SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 Pfam PF00364 Biotin-requiring enzyme 85 156 1.4E-22 T 21-04-2016 IPR000089 Biotin/lipoyl attachment SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 PRINTS PR01071 Acetyl-CoA biotin carboxyl carrier protein signature 120 133 2.9E-18 T 21-04-2016 IPR001249 Acetyl-CoA biotin carboxyl carrier GO:0003989|GO:0006633|GO:0009317 UniPathway: UPA00094 SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 PRINTS PR01071 Acetyl-CoA biotin carboxyl carrier protein signature 105 119 2.9E-18 T 21-04-2016 IPR001249 Acetyl-CoA biotin carboxyl carrier GO:0003989|GO:0006633|GO:0009317 UniPathway: UPA00094 SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 PRINTS PR01071 Acetyl-CoA biotin carboxyl carrier protein signature 88 101 2.9E-18 T 21-04-2016 IPR001249 Acetyl-CoA biotin carboxyl carrier GO:0003989|GO:0006633|GO:0009317 UniPathway: UPA00094 SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 Gene3D G3DSA:2.40.50.100 84 158 2.7E-29 T 21-04-2016 SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 PANTHER PTHR23151 3 158 9.7E-47 T 21-04-2016 SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 SUPERFAMILY SSF51230 83 158 5.5E-23 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS00060 d7bc7143d9b060b5b2a4308193c4d297 161 TIGRFAM TIGR00531 BCCP: acetyl-CoA carboxylase, biotin carboxyl carrier protein 3 159 1.4E-52 T 21-04-2016 IPR001249 Acetyl-CoA biotin carboxyl carrier GO:0003989|GO:0006633|GO:0009317 UniPathway: UPA00094 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 Gene3D G3DSA:3.40.718.10 2 353 7.2E-121 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 Hamap MF_01033 3-isopropylmalate dehydrogenase [leuB]. 3 353 44.292 T 21-04-2016 IPR004429 Isopropylmalate dehydrogenase GO:0003862|GO:0005737|GO:0009098|GO:0055114 KEGG: 00290+1.1.1.85|KEGG: 00660+1.1.1.85|MetaCyc: PWY-7396|UniPathway: UPA00048 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 PANTHER PTHR11835 4 353 6.9E-172 T 21-04-2016 IPR001804 Isocitrate and isopropylmalate dehydrogenases family GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: REACT_1046 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 241 260 - T 21-04-2016 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: REACT_1046 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 SUPERFAMILY SSF53659 1 353 6.72E-113 T 21-04-2016 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 PANTHER PTHR11835:SF35 4 353 6.9E-172 T 21-04-2016 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 TIGRFAM TIGR00169 leuB: 3-isopropylmalate dehydrogenase 4 347 2.3E-137 T 21-04-2016 IPR004429 Isopropylmalate dehydrogenase GO:0003862|GO:0005737|GO:0009098|GO:0055114 KEGG: 00290+1.1.1.85|KEGG: 00660+1.1.1.85|MetaCyc: PWY-7396|UniPathway: UPA00048 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 SMART SM01329 4 349 1.4E-172 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS11225 1ba9c9a5bfced787925e5038a8a5b3a3 353 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 4 347 4.7E-123 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 PRINTS PR00344 Bacterial sensor protein C-terminal signature 314 324 5.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 PRINTS PR00344 Bacterial sensor protein C-terminal signature 296 310 5.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 PRINTS PR00344 Bacterial sensor protein C-terminal signature 330 348 5.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 PRINTS PR00344 Bacterial sensor protein C-terminal signature 354 367 5.0E-14 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 Gene3D G3DSA:1.10.287.130 139 202 4.1E-16 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 Gene3D G3DSA:3.40.50.2300 2 136 3.0E-34 T 21-04-2016 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 SUPERFAMILY SSF55874 204 368 3.14E-40 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 SMART SM00388 147 215 3.2E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 Gene3D G3DSA:3.30.565.10 203 368 4.6E-41 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 259 368 2.5E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 Pfam PF00072 Response regulator receiver domain 2 114 9.3E-26 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 PANTHER PTHR24423 122 369 1.6E-67 T 21-04-2016 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 Pfam PF00512 His Kinase A (phospho-acceptor) domain 148 215 2.2E-17 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 SMART SM00387 258 369 1.7E-27 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 SMART SM00448 1 114 3.9E-31 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05470 b45be5d5d221f2c1ef1f1e6e232d8726 369 SUPERFAMILY SSF52172 2 165 3.56E-36 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Gene3D G3DSA:3.40.1190.10 96 308 8.7E-40 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Pfam PF01225 Mur ligase family, catalytic domain 27 101 2.8E-5 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 TIGRFAM TIGR00492 alr: alanine racemase 453 813 4.2E-87 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Pfam PF01168 Alanine racemase, N-terminal domain 458 678 1.2E-52 T 21-04-2016 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PANTHER PTHR30511 448 816 2.1E-108 T 21-04-2016 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PANTHER PTHR30511:SF0 448 816 2.1E-108 T 21-04-2016 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Pfam PF00842 Alanine racemase, C-terminal domain 690 813 4.0E-36 T 21-04-2016 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PRINTS PR00992 Alanine racemase signature 574 586 3.8E-39 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PRINTS PR00992 Alanine racemase signature 513 531 3.8E-39 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PRINTS PR00992 Alanine racemase signature 652 679 3.8E-39 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PRINTS PR00992 Alanine racemase signature 745 762 3.8E-39 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PRINTS PR00992 Alanine racemase signature 477 493 3.8E-39 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 PRINTS PR00992 Alanine racemase signature 796 809 3.8E-39 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 SMART SM01005 690 814 5.2E-53 T 21-04-2016 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Gene3D G3DSA:3.90.190.20 312 448 3.5E-25 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 SUPERFAMILY SSF63418 12 102 2.22E-15 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 SUPERFAMILY SSF50621 684 814 3.49E-42 T 21-04-2016 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Hamap MF_01201 Alanine racemase. 451 814 28.391 T 21-04-2016 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383|UniPathway: UPA00042 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 SUPERFAMILY SSF53623 106 309 1.83E-29 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Gene3D G3DSA:3.20.20.10 460 671 2.5E-59 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Gene3D G3DSA:2.40.37.10 672 814 4.2E-51 T 21-04-2016 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Pfam PF08245 Mur ligase middle domain 111 292 5.2E-24 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 SUPERFAMILY SSF53244 313 447 5.04E-22 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 Gene3D G3DSA:3.40.1390.10 20 95 2.1E-12 T 21-04-2016 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS23065 96abb2491ac3ba2147bf618ce8d84033 816 SUPERFAMILY SSF51419 458 681 2.8E-52 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS15405 e32fe9bf2694a9758f7c51fb6f00514f 277 PANTHER PTHR30589:SF0 4 271 2.1E-66 T 21-04-2016 SPH21_RS15405 e32fe9bf2694a9758f7c51fb6f00514f 277 PANTHER PTHR30589 4 271 2.1E-66 T 21-04-2016 SPH21_RS15405 e32fe9bf2694a9758f7c51fb6f00514f 277 Pfam PF01790 Prolipoprotein diacylglyceryl transferase 14 266 2.5E-69 T 21-04-2016 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 UniPathway: UPA00664 SPH21_RS15405 e32fe9bf2694a9758f7c51fb6f00514f 277 ProSitePatterns PS01311 Prolipoprotein diacylglyceryl transferase signature. 152 164 - T 21-04-2016 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 UniPathway: UPA00664 SPH21_RS15405 e32fe9bf2694a9758f7c51fb6f00514f 277 TIGRFAM TIGR00544 lgt: prolipoprotein diacylglyceryl transferase 12 269 2.3E-45 T 21-04-2016 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 UniPathway: UPA00664 SPH21_RS15405 e32fe9bf2694a9758f7c51fb6f00514f 277 Hamap MF_01147 Prolipoprotein diacylglyceryl transferase [lgt]. 11 272 15.927 T 21-04-2016 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 UniPathway: UPA00664 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 Pfam PF04413 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) 47 207 7.9E-46 T 21-04-2016 IPR007507 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal KEGG: 00540+2.4.99.12|MetaCyc: PWY-7675|UniPathway: UPA00958 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 PANTHER PTHR23417:SF2 52 110 4.2E-47 T 21-04-2016 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 PANTHER PTHR23417:SF2 186 409 4.2E-47 T 21-04-2016 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 PANTHER PTHR23417:SF2 129 139 4.2E-47 T 21-04-2016 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 SUPERFAMILY SSF53756 52 398 1.04E-13 T 21-04-2016 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 PANTHER PTHR23417 52 110 4.2E-47 T 21-04-2016 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 PANTHER PTHR23417 186 409 4.2E-47 T 21-04-2016 SPH21_RS05145 09b52302fd95ad9565eea5d45f9be541 413 PANTHER PTHR23417 129 139 4.2E-47 T 21-04-2016 SPH21_RS14495 6d6b325adc99b283861a2a85d4724b34 327 Pfam PF00268 Ribonucleotide reductase, small chain 7 282 1.4E-78 T 21-04-2016 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: REACT_1698|UniPathway: UPA00326 SPH21_RS14495 6d6b325adc99b283861a2a85d4724b34 327 ProSitePatterns PS00368 Ribonucleotide reductase small subunit signature. 95 111 - T 21-04-2016 IPR030475 Ribonucleotide reductase small subunit, acitve site KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS14495 6d6b325adc99b283861a2a85d4724b34 327 PANTHER PTHR23409 19 316 2.1E-75 T 21-04-2016 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: REACT_1698|UniPathway: UPA00326 SPH21_RS14495 6d6b325adc99b283861a2a85d4724b34 327 Gene3D G3DSA:1.10.620.20 3 283 6.0E-74 T 21-04-2016 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: REACT_1698 SPH21_RS14495 6d6b325adc99b283861a2a85d4724b34 327 TIGRFAM TIGR04171 RNR_1b_NrdF: ribonucleoside-diphosphate reductase, class 1b, beta subunit 4 320 7.5E-137 T 21-04-2016 IPR026494 Ribonucleoside reductase subunit beta, NrdF GO:0005971|GO:0009263 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS14495 6d6b325adc99b283861a2a85d4724b34 327 PIRSF PIRSF000355 1 317 9.0E-75 T 21-04-2016 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: REACT_1698|UniPathway: UPA00326 SPH21_RS14495 6d6b325adc99b283861a2a85d4724b34 327 SUPERFAMILY SSF47240 2 318 3.45E-85 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 SUPERFAMILY SSF50939 310 548 1.49E-86 T 21-04-2016 IPR011040 Sialidases SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 SUPERFAMILY SSF50939 176 280 1.49E-86 T 21-04-2016 IPR011040 Sialidases SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 Gene3D G3DSA:2.120.10.10 177 546 2.1E-93 T 21-04-2016 IPR011040 Sialidases SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 Pfam PF13088 BNR repeat-like domain 195 529 3.2E-26 T 21-04-2016 IPR011040 Sialidases SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 PANTHER PTHR10628 295 549 1.7E-90 T 21-04-2016 IPR026856 Sialidase family GO:0004308 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 PANTHER PTHR10628 106 269 1.7E-90 T 21-04-2016 IPR026856 Sialidase family GO:0004308 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 Pfam PF14873 N-terminal domain of BNR-repeat neuraminidase 26 153 1.7E-35 T 21-04-2016 IPR029456 Sialidase, N-terminal KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 PANTHER PTHR10628:SF19 295 549 1.7E-90 T 21-04-2016 SPH21_RS25470 987bdb827894e7c0871eefec575e099d 553 PANTHER PTHR10628:SF19 106 269 1.7E-90 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Gene3D G3DSA:2.40.170.20 934 988 1.7E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Gene3D G3DSA:2.40.170.20 447 789 1.7E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Gene3D G3DSA:2.40.170.20 290 400 1.7E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Gene3D G3DSA:2.40.170.20 847 879 1.7E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Gene3D G3DSA:2.40.170.20 244 256 1.7E-32 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Pfam PF13715 CarboxypepD_reg-like domain 26 106 2.7E-15 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 220 250 2.6E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 SUPERFAMILY SSF56935 103 268 1.03E-76 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 SUPERFAMILY SSF56935 314 401 1.03E-76 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 SUPERFAMILY SSF56935 930 1001 1.03E-76 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 SUPERFAMILY SSF56935 445 779 1.03E-76 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 SUPERFAMILY SSF56935 838 881 1.03E-76 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 1027 6.3E-200 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 SUPERFAMILY SSF49464 25 119 1.7E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 PANTHER PTHR11532:SF51 211 442 2.3E-191 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 PANTHER PTHR11532:SF51 19 189 2.3E-191 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 PANTHER PTHR11532:SF51 517 1025 2.3E-191 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Gene3D G3DSA:2.170.130.10 109 243 9.1E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 PANTHER PTHR11532 211 442 2.3E-191 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 PANTHER PTHR11532 19 189 2.3E-191 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 PANTHER PTHR11532 517 1025 2.3E-191 T 21-04-2016 SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Gene3D G3DSA:2.60.40.1120 25 108 1.6E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS16260 b14f700e3d9d5295dc49f6fe55b42631 1027 Pfam PF07715 TonB-dependent Receptor Plug Domain 116 244 4.1E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PANTHER PTHR11958 1 415 5.5E-229 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 Gene3D G3DSA:1.10.3860.10 5 406 4.7E-118 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PANTHER PTHR11958:SF49 1 415 5.5E-229 T 21-04-2016 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PRINTS PR00173 Glutamate-aspartate symporter signature 327 346 4.6E-36 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PRINTS PR00173 Glutamate-aspartate symporter signature 292 318 4.6E-36 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PRINTS PR00173 Glutamate-aspartate symporter signature 145 167 4.6E-36 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PRINTS PR00173 Glutamate-aspartate symporter signature 2 22 4.6E-36 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PRINTS PR00173 Glutamate-aspartate symporter signature 43 63 4.6E-36 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 PRINTS PR00173 Glutamate-aspartate symporter signature 73 98 4.6E-36 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 SUPERFAMILY SSF118215 8 402 2.62E-120 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 Pfam PF00375 Sodium:dicarboxylate symporter family 8 401 1.7E-114 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 ProSitePatterns PS00713 Sodium:dicarboxylate symporter family signature 1. 35 50 - T 21-04-2016 IPR018107 Sodium:dicarboxylate symporter, conserved site Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS06055 a62fd788c9a51bdff00813c92175889d 415 ProSitePatterns PS00714 Sodium:dicarboxylate symporter family signature 2. 295 318 - T 21-04-2016 IPR018107 Sodium:dicarboxylate symporter, conserved site Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 PANTHER PTHR11113:SF7 1 360 8.3E-97 T 21-04-2016 SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 SUPERFAMILY SSF51556 48 342 5.44E-79 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 Gene3D G3DSA:3.20.20.140 49 324 3.8E-80 T 21-04-2016 SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 TIGRFAM TIGR00221 nagA: N-acetylglucosamine-6-phosphate deacetylase 5 360 3.4E-84 T 21-04-2016 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395 SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 PANTHER PTHR11113 1 360 8.3E-97 T 21-04-2016 SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 PIRSF PIRSF038994 1 367 4.4E-97 T 21-04-2016 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395 SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 Pfam PF01979 Amidohydrolase family 46 357 1.2E-16 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS20425 70d6beb9a26bcf4ba7ff3042fb729034 367 Gene3D G3DSA:2.30.40.10 325 365 1.9E-6 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS19010 49cd2293e9b0b431f26d5851c64f3840 329 PANTHER PTHR22916 1 203 1.2E-28 T 21-04-2016 SPH21_RS19010 49cd2293e9b0b431f26d5851c64f3840 329 Pfam PF00535 Glycosyl transferase family 2 7 165 8.9E-24 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS19010 49cd2293e9b0b431f26d5851c64f3840 329 PANTHER PTHR22916:SF29 1 203 1.2E-28 T 21-04-2016 SPH21_RS19010 49cd2293e9b0b431f26d5851c64f3840 329 SUPERFAMILY SSF53448 6 282 1.89E-43 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS19010 49cd2293e9b0b431f26d5851c64f3840 329 Gene3D G3DSA:3.90.550.10 5 224 3.2E-37 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS13220 d6b08055dab9ff618615acf9a151bb46 480 Gene3D G3DSA:1.20.1600.10 31 474 5.6E-41 T 21-04-2016 SPH21_RS13220 d6b08055dab9ff618615acf9a151bb46 480 PANTHER PTHR30026 32 474 1.6E-26 T 21-04-2016 SPH21_RS13220 d6b08055dab9ff618615acf9a151bb46 480 SUPERFAMILY SSF56954 115 474 3.14E-49 T 21-04-2016 SPH21_RS13220 d6b08055dab9ff618615acf9a151bb46 480 SUPERFAMILY SSF56954 5 86 3.14E-49 T 21-04-2016 SPH21_RS13220 d6b08055dab9ff618615acf9a151bb46 480 Pfam PF02321 Outer membrane efflux protein 288 471 2.2E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS13220 d6b08055dab9ff618615acf9a151bb46 480 Pfam PF02321 Outer membrane efflux protein 35 248 1.7E-19 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS10650 9238f82540403e80b4e37430fa5c5e25 220 Pfam PF01177 Asp/Glu/Hydantoin racemase 56 196 1.7E-6 T 21-04-2016 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS10650 9238f82540403e80b4e37430fa5c5e25 220 Gene3D G3DSA:3.40.50.1860 23 124 3.8E-10 T 21-04-2016 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 PANTHER PTHR12029 9 245 3.6E-49 T 21-04-2016 SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 Pfam PF00588 SpoU rRNA Methylase family 106 240 1.1E-33 T 21-04-2016 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 SMART SM00967 26 95 9.5E-8 T 21-04-2016 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 SUPERFAMILY SSF75217 83 246 6.15E-36 T 21-04-2016 IPR029028 Alpha/beta knot methyltransferases SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 Pfam PF08032 RNA 2'-O ribose methyltransferase substrate binding 26 92 2.9E-5 T 21-04-2016 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 SUPERFAMILY SSF55315 4 92 3.18E-17 T 21-04-2016 IPR029064 50S ribosomal protein L30e-like SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 Gene3D G3DSA:3.30.1330.30 1 93 5.1E-24 T 21-04-2016 IPR029064 50S ribosomal protein L30e-like SPH21_RS15875 ed1d006c3cfd400e4ce2963dd50bb357 252 Gene3D G3DSA:3.40.1280.10 103 247 1.4E-39 T 21-04-2016 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SPH21_RS00970 8ca736fb483497d645b242cba3c428aa 563 PANTHER PTHR11819 6 521 2.1E-119 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS00970 8ca736fb483497d645b242cba3c428aa 563 Pfam PF00474 Sodium:solute symporter family 42 465 1.7E-57 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS00970 8ca736fb483497d645b242cba3c428aa 563 PANTHER PTHR11819:SF7 6 521 2.1E-119 T 21-04-2016 SPH21_RS00970 8ca736fb483497d645b242cba3c428aa 563 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 42 465 5.2E-83 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS26025 9bb61cf572a96f2883379a7573be9b61 236 Pfam PF07291 Methylamine utilisation protein MauE 88 216 1.4E-6 T 21-04-2016 IPR009908 Methylamine utilisation protein, MauE GO:0016021|GO:0030416 UniPathway: UPA00895 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 PANTHER PTHR11532 464 1006 1.4E-232 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 PANTHER PTHR11532 3 367 1.4E-232 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 Gene3D G3DSA:2.60.40.1120 35 117 2.7E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 SUPERFAMILY SSF56935 849 893 5.04E-87 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 SUPERFAMILY SSF56935 111 253 5.04E-87 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 SUPERFAMILY SSF56935 313 777 5.04E-87 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 SUPERFAMILY SSF56935 925 1008 5.04E-87 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 PANTHER PTHR11532:SF57 464 1006 1.4E-232 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 PANTHER PTHR11532:SF57 3 367 1.4E-232 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 Pfam PF07715 TonB-dependent Receptor Plug Domain 121 229 5.3E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 206 235 4.4E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 33 1008 9.0E-250 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 SUPERFAMILY SSF49464 34 106 4.97E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 Gene3D G3DSA:2.170.130.10 118 229 6.6E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 Pfam PF13715 CarboxypepD_reg-like domain 35 114 7.9E-17 T 21-04-2016 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 Gene3D G3DSA:2.40.170.20 322 785 6.7E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 Gene3D G3DSA:2.40.170.20 230 249 6.7E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09305 72a528a18efa740f072505c7649df36d 1008 Gene3D G3DSA:2.40.170.20 858 1008 6.7E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PANTHER PTHR24322:SF631 20 148 9.7E-52 T 21-04-2016 SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PANTHER PTHR24322:SF631 164 196 9.7E-52 T 21-04-2016 SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 202 4.4E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 4.4E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 164 183 4.4E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 4.4E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 138 154 4.4E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 91 102 7.3E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 164 183 7.3E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 144 152 7.3E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 151 179 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 Gene3D G3DSA:3.40.50.720 16 235 1.5E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 Pfam PF00106 short chain dehydrogenase 17 204 9.5E-47 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 SUPERFAMILY SSF51735 14 256 1.66E-55 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PANTHER PTHR24322 20 148 9.7E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05140 e0fcc9cc8f615cbe208b9031b4858401 275 PANTHER PTHR24322 164 196 9.7E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 TIGRFAM TIGR01972 NDH_I_M: proton-translocating NADH-quinone oxidoreductase, chain M 4 527 9.7E-165 T 21-04-2016 IPR010227 NADH-quinone oxidoreductase, chain M/4 GO:0008137|GO:0042773|GO:0055114 SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 Pfam PF00361 Proton-conducting membrane transporter 140 441 4.5E-72 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 PANTHER PTHR22773 1 530 7.0E-166 T 21-04-2016 SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 PANTHER PTHR22773:SF40 1 530 7.0E-166 T 21-04-2016 SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 268 292 2.6E-31 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 408 434 2.6E-31 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 356 375 2.6E-31 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS10880 27b9ebdff549acc39628aff26378248b 534 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 146 165 2.6E-31 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS11470 50be7eea24990b97222f27571fbb9bba 376 Gene3D G3DSA:2.115.10.20 61 162 2.0E-10 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS11470 50be7eea24990b97222f27571fbb9bba 376 Gene3D G3DSA:2.115.10.20 167 304 3.2E-14 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS11470 50be7eea24990b97222f27571fbb9bba 376 SUPERFAMILY SSF75005 54 193 7.28E-11 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS11470 50be7eea24990b97222f27571fbb9bba 376 SUPERFAMILY SSF75005 173 359 3.23E-16 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 SUPERFAMILY SSF56436 54 102 8.95E-55 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 SUPERFAMILY SSF56436 195 430 8.95E-55 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 Gene3D G3DSA:3.90.1580.10 53 104 9.8E-72 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 Gene3D G3DSA:3.90.1580.10 189 431 9.8E-72 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 PANTHER PTHR23150 225 258 9.9E-32 T 21-04-2016 SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 PANTHER PTHR23150 276 431 9.9E-32 T 21-04-2016 SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 PANTHER PTHR23150 56 152 9.9E-32 T 21-04-2016 SPH21_RS09910 684f05be7b3c7b3ac1cde3b26ba9fd2a 446 Pfam PF03781 Sulfatase-modifying factor enzyme 1 56 428 1.2E-46 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS00200 4804b0fdc386d5c0d6d8bcaef332b6c9 124 PANTHER PTHR34299:SF1 3 117 4.6E-30 T 21-04-2016 SPH21_RS00200 4804b0fdc386d5c0d6d8bcaef332b6c9 124 Gene3D G3DSA:1.10.3830.10 3 114 7.7E-38 T 21-04-2016 SPH21_RS00200 4804b0fdc386d5c0d6d8bcaef332b6c9 124 PANTHER PTHR34299 3 117 4.6E-30 T 21-04-2016 SPH21_RS00200 4804b0fdc386d5c0d6d8bcaef332b6c9 124 Pfam PF01219 Prokaryotic diacylglycerol kinase 9 109 1.9E-33 T 21-04-2016 IPR000829 Diacylglycerol kinase, prokaryotic GO:0004143|GO:0008654|GO:0016020 KEGG: 00500+2.7.1.10|KEGG: 00561+2.7.1.107|KEGG: 00564+2.7.1.107|KEGG: 04070+2.7.1.107|MetaCyc: PWY-7039 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 288 5.7E-24 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 SUPERFAMILY SSF51905 1 309 2.75E-34 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 4.1E-13 T 21-04-2016 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 266 288 4.1E-13 T 21-04-2016 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 239 255 4.1E-13 T 21-04-2016 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 153 171 4.1E-13 T 21-04-2016 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 276 294 1.6E-21 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 110 118 1.6E-21 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 5 27 1.6E-21 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 204 220 1.6E-21 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 62 72 1.6E-21 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 149 173 1.6E-21 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 Gene3D G3DSA:3.50.50.60 126 243 6.3E-23 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PANTHER PTHR22912 1 319 2.4E-93 T 21-04-2016 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 PANTHER PTHR22912:SF158 1 319 2.4E-93 T 21-04-2016 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 Hamap MF_01685 Ferredoxin--NADP reductase. 3 329 40.137 T 21-04-2016 IPR022890 Ferredoxin--NADP reductase, type 2 GO:0004324|GO:0055114 KEGG: 00195+1.18.1.2|MetaCyc: PWY-101|MetaCyc: PWY-7230 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 Gene3D G3DSA:3.50.50.60 247 327 5.3E-38 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14780 a6f6f99ebc2e9dad3956e45821c25bca 334 Gene3D G3DSA:3.50.50.60 3 124 5.3E-38 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12950 bde950fe3facaaca4f527d817c402c42 289 SUPERFAMILY SSF51182 14 287 5.56E-74 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS12950 bde950fe3facaaca4f527d817c402c42 289 Gene3D G3DSA:2.60.120.10 17 259 6.6E-72 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS12950 bde950fe3facaaca4f527d817c402c42 289 Pfam PF05726 Pirin C-terminal cupin domain 186 286 9.5E-29 T 21-04-2016 IPR008778 Pirin, C-terminal domain SPH21_RS12950 bde950fe3facaaca4f527d817c402c42 289 PIRSF PIRSF006232 3 289 5.0E-84 T 21-04-2016 IPR012093 Pirin SPH21_RS12950 bde950fe3facaaca4f527d817c402c42 289 PANTHER PTHR13903:SF12 18 286 7.4E-115 T 21-04-2016 SPH21_RS12950 bde950fe3facaaca4f527d817c402c42 289 Pfam PF02678 Pirin 23 130 2.8E-30 T 21-04-2016 IPR003829 Pirin, N-terminal domain SPH21_RS12950 bde950fe3facaaca4f527d817c402c42 289 PANTHER PTHR13903 18 286 7.4E-115 T 21-04-2016 IPR012093 Pirin SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 Hamap MF_00403_B 30S ribosomal protein S12 [rpsL]. 1 123 40.111 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PRINTS PR01034 Ribosomal protein S12 signature 94 110 9.6E-60 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PRINTS PR01034 Ribosomal protein S12 signature 77 94 9.6E-60 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PRINTS PR01034 Ribosomal protein S12 signature 42 57 9.6E-60 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PRINTS PR01034 Ribosomal protein S12 signature 58 77 9.6E-60 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PRINTS PR01034 Ribosomal protein S12 signature 27 42 9.6E-60 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PRINTS PR01034 Ribosomal protein S12 signature 110 122 9.6E-60 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 Gene3D G3DSA:2.40.50.140 1 123 7.4E-67 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PIRSF PIRSF002133 1 124 8.7E-56 T 21-04-2016 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 TIGRFAM TIGR00981 rpsL_bact: ribosomal protein uS12 1 123 3.7E-69 T 21-04-2016 IPR005679 Ribosomal protein S12, bacteria GO:0003735|GO:0006412|GO:0015935 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 SUPERFAMILY SSF50249 2 123 1.63E-53 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 ProSitePatterns PS00055 Ribosomal protein S12 signature. 43 50 - T 21-04-2016 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 Pfam PF00164 Ribosomal protein S12/S23 3 123 2.0E-44 T 21-04-2016 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS19760 63029be62f706c1e7f1e5647b3e6c1b1 137 PANTHER PTHR11652 1 116 2.7E-75 T 21-04-2016 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 1056 8.6E-242 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 SUPERFAMILY SSF49464 26 107 5.23E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 198 228 4.5E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Gene3D G3DSA:2.170.130.10 113 222 2.6E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 SUPERFAMILY SSF56935 333 421 6.72E-86 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 SUPERFAMILY SSF56935 961 1054 6.72E-86 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 SUPERFAMILY SSF56935 449 781 6.72E-86 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 SUPERFAMILY SSF56935 105 247 6.72E-86 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 SUPERFAMILY SSF56935 874 917 6.72E-86 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532:SF57 1 303 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532:SF57 517 547 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532:SF57 323 387 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532:SF57 416 451 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532:SF57 572 1054 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532 1 303 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532 517 547 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532 323 387 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532 416 451 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 PANTHER PTHR11532 572 1054 3.9E-226 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Pfam PF13715 CarboxypepD_reg-like domain 28 109 6.8E-15 T 21-04-2016 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Gene3D G3DSA:2.60.40.1120 28 112 1.5E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Gene3D G3DSA:2.40.170.20 882 907 2.0E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Gene3D G3DSA:2.40.170.20 223 243 2.0E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Gene3D G3DSA:2.40.170.20 342 799 2.0E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Gene3D G3DSA:2.40.170.20 952 1055 2.0E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS25455 2bdf068ae91ed584bca376c59006e7ff 1056 Pfam PF07715 TonB-dependent Receptor Plug Domain 118 222 2.1E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 PANTHER PTHR10804 1 250 1.7E-78 T 21-04-2016 SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 89 105 1.9E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 191 203 1.9E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 159 171 1.9E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 PRINTS PR00599 Methionine aminopeptidase-1 signature 66 79 1.9E-16 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 Pfam PF00557 Metallopeptidase family M24 12 240 5.9E-41 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 Gene3D G3DSA:3.90.230.10 4 248 3.0E-67 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 SUPERFAMILY SSF55920 5 247 3.4E-60 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 Hamap MF_01974 Methionine aminopeptidase [map]. 1 249 31.636 T 21-04-2016 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 1 248 7.6E-77 T 21-04-2016 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SPH21_RS21165 0c6d13c0a506f47643306a7043d6043a 254 PANTHER PTHR10804:SF41 1 250 1.7E-78 T 21-04-2016 SPH21_RS17890 72f6cd3459182a2b7d8427a97fc3fdcc 166 PANTHER PTHR30574 34 158 4.4E-36 T 21-04-2016 SPH21_RS17890 72f6cd3459182a2b7d8427a97fc3fdcc 166 Pfam PF04143 Sulphur transport 55 158 7.9E-11 T 21-04-2016 IPR007272 Sulphur transport domain SPH21_RS17890 72f6cd3459182a2b7d8427a97fc3fdcc 166 PANTHER PTHR30574:SF7 34 158 4.4E-36 T 21-04-2016 SPH21_RS06105 b64531380447c7b377f421a3fddef849 337 Gene3D G3DSA:3.90.1640.10 15 207 2.0E-29 T 21-04-2016 SPH21_RS06105 b64531380447c7b377f421a3fddef849 337 Pfam PF01368 DHH family 17 168 9.5E-15 T 21-04-2016 IPR001667 DDH domain SPH21_RS06105 b64531380447c7b377f421a3fddef849 337 SUPERFAMILY SSF64182 15 314 1.83E-52 T 21-04-2016 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 ProSitePatterns PS01054 Transaldolase signature 1. 41 49 - T 21-04-2016 IPR018225 Transaldolase, active site GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 TIGRFAM TIGR00876 tal_mycobact: transaldolase 13 363 9.4E-99 T 21-04-2016 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 PANTHER PTHR10683 1 368 1.4E-116 T 21-04-2016 IPR001585 Transaldolase/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 Hamap MF_00493 Transaldolase [tal]. 1 375 129.358 T 21-04-2016 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 Pfam PF00923 Transaldolase 15 364 2.4E-79 T 21-04-2016 IPR001585 Transaldolase/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 Gene3D G3DSA:3.20.20.70 2 366 7.8E-112 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 PANTHER PTHR10683:SF12 1 368 1.4E-116 T 21-04-2016 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 ProSitePatterns PS00958 Transaldolase active site. 137 154 - T 21-04-2016 IPR018225 Transaldolase, active site GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 PIRSF PIRSF036915 1 375 8.9E-142 T 21-04-2016 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|UniPathway: UPA00115 SPH21_RS10785 9804f3f1f017cee4dd82e46a3863e6c9 375 SUPERFAMILY SSF51569 5 370 2.2E-74 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:1.20.1580.10 259 292 4.7E-50 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:1.20.1580.10 102 140 4.7E-50 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:1.20.1580.10 410 482 4.7E-50 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Pfam PF00005 ABC transporter 626 862 1.3E-9 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 TIGRFAM TIGR00630 uvra: excinuclease ABC subunit A 15 926 0.0 T 21-04-2016 IPR004602 UvrABC system subunit A GO:0006289|GO:0009380|GO:0009381 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:3.40.50.300 615 694 5.1E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:3.40.50.300 823 942 5.1E-57 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:3.40.50.300 15 62 4.9E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:3.40.50.300 483 597 4.9E-52 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 ProSitePatterns PS00211 ABC transporters family signature. 832 846 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 ProSitePatterns PS00211 ABC transporters family signature. 492 506 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 PANTHER PTHR32282:SF2 11 949 0.0 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 SUPERFAMILY SSF52540 617 915 1.73E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 PANTHER PTHR32282 11 949 0.0 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:1.20.1580.10 696 822 1.3E-52 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:1.10.8.280 294 409 1.4E-25 T 21-04-2016 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:3.30.1490.20 143 164 2.5E-13 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 Gene3D G3DSA:3.30.1490.20 211 256 2.5E-13 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 SUPERFAMILY SSF52540 20 215 1.18E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25950 70594528adbd20eaf0c880bff8c1f822 952 SUPERFAMILY SSF52540 436 574 1.18E-41 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01095 af2df908ec97e3ee7ae5222f8254f33b 264 SUPERFAMILY SSF55008 1 61 3.53E-8 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01095 af2df908ec97e3ee7ae5222f8254f33b 264 Gene3D G3DSA:1.20.1510.10 85 260 1.9E-18 T 21-04-2016 IPR027469 Cation efflux protein transmembrane domain SPH21_RS01095 af2df908ec97e3ee7ae5222f8254f33b 264 PANTHER PTHR11562 81 260 1.4E-17 T 21-04-2016 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SPH21_RS01095 af2df908ec97e3ee7ae5222f8254f33b 264 PANTHER PTHR11562:SF17 81 260 1.4E-17 T 21-04-2016 SPH21_RS01095 af2df908ec97e3ee7ae5222f8254f33b 264 Pfam PF01545 Cation efflux family 88 260 9.8E-12 T 21-04-2016 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SPH21_RS01095 af2df908ec97e3ee7ae5222f8254f33b 264 SUPERFAMILY SSF161111 82 260 2.35E-28 T 21-04-2016 SPH21_RS01095 af2df908ec97e3ee7ae5222f8254f33b 264 Gene3D G3DSA:3.30.70.100 1 60 6.9E-6 T 21-04-2016 SPH21_RS00675 6cb209950216e815847c5036b489e53a 377 PANTHER PTHR30388 171 377 2.9E-80 T 21-04-2016 SPH21_RS00675 6cb209950216e815847c5036b489e53a 377 PANTHER PTHR30388 5 129 2.9E-80 T 21-04-2016 SPH21_RS00675 6cb209950216e815847c5036b489e53a 377 Pfam PF13478 XdhC Rossmann domain 206 350 9.8E-35 T 21-04-2016 IPR027051 XdhC Rossmann domain SPH21_RS00675 6cb209950216e815847c5036b489e53a 377 PANTHER PTHR30388:SF4 171 377 2.9E-80 T 21-04-2016 SPH21_RS00675 6cb209950216e815847c5036b489e53a 377 PANTHER PTHR30388:SF4 5 129 2.9E-80 T 21-04-2016 SPH21_RS00675 6cb209950216e815847c5036b489e53a 377 Pfam PF02625 XdhC and CoxI family 15 81 1.9E-21 T 21-04-2016 IPR003777 XdhC- CoxI SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 SUPERFAMILY SSF46689 5 76 4.59E-17 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 1.6E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 1.6E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 SUPERFAMILY SSF48498 87 185 7.28E-17 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 Pfam PF13305 WHG domain 91 181 3.0E-17 T 21-04-2016 IPR025996 WHG domain SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 PANTHER PTHR30055 3 181 1.9E-28 T 21-04-2016 SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 Gene3D G3DSA:1.10.357.10 1 181 2.6E-38 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS22860 7a6d5b443ee235cb67d3d49e0d3e6a9c 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 60 6.2E-12 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS18605 d93203eca3cc61fa336fe20b226006a5 246 PANTHER PTHR30269 1 245 9.2E-35 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS18605 d93203eca3cc61fa336fe20b226006a5 246 Pfam PF01925 Sulfite exporter TauE/SafE 9 239 4.2E-32 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS18605 d93203eca3cc61fa336fe20b226006a5 246 PANTHER PTHR30269:SF0 1 245 9.2E-35 T 21-04-2016 SPH21_RS12780 87417f498f646f92a844b920e2af1011 160 Pfam PF08922 Domain of unknown function (DUF1905) 16 84 2.2E-6 T 21-04-2016 IPR015018 Protein of unknown function DUF1905 SPH21_RS12780 87417f498f646f92a844b920e2af1011 160 SUPERFAMILY SSF141694 2 86 1.46E-8 T 21-04-2016 SPH21_RS12780 87417f498f646f92a844b920e2af1011 160 Pfam PF13376 Bacteriocin-protection, YdeI or OmpD-Associated 99 134 4.0E-7 T 21-04-2016 SPH21_RS12780 87417f498f646f92a844b920e2af1011 160 Gene3D G3DSA:2.40.30.100 30 85 1.6E-5 T 21-04-2016 SPH21_RS22470 ed19fb453ed0ea778e5fba0b981814cf 141 Gene3D G3DSA:3.10.129.10 6 132 2.0E-16 T 21-04-2016 IPR029069 HotDog domain SPH21_RS22470 ed19fb453ed0ea778e5fba0b981814cf 141 SUPERFAMILY SSF54637 7 135 3.73E-21 T 21-04-2016 IPR029069 HotDog domain SPH21_RS22470 ed19fb453ed0ea778e5fba0b981814cf 141 Pfam PF13279 Thioesterase-like superfamily 7 127 1.1E-12 T 21-04-2016 SPH21_RS02730 d3170ee1cfa5fa10c5e0dac38555ece1 140 PANTHER PTHR34352 25 139 1.2E-33 T 21-04-2016 SPH21_RS02730 d3170ee1cfa5fa10c5e0dac38555ece1 140 SUPERFAMILY SSF82784 2 135 1.7E-32 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS02730 d3170ee1cfa5fa10c5e0dac38555ece1 140 Pfam PF02566 OsmC-like protein 36 133 2.1E-19 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS02730 d3170ee1cfa5fa10c5e0dac38555ece1 140 Gene3D G3DSA:3.30.300.20 41 136 1.1E-32 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 Pfam PF02347 Glycine cleavage system P-protein 456 733 2.8E-9 T 21-04-2016 IPR020580 Glycine cleavage system P-protein, N-terminal GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2 SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 Pfam PF02347 Glycine cleavage system P-protein 13 437 1.8E-178 T 21-04-2016 IPR020580 Glycine cleavage system P-protein, N-terminal GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2 SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 SUPERFAMILY SSF53383 14 440 3.77E-100 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 PANTHER PTHR11773 8 955 0.0 T 21-04-2016 IPR020581 Glycine cleavage system P protein GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2 SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 SUPERFAMILY SSF53383 926 949 1.39E-92 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 PANTHER PTHR11773:SF1 8 955 0.0 T 21-04-2016 SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 Gene3D G3DSA:3.40.640.10 500 746 7.9E-39 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 Gene3D G3DSA:3.40.640.10 81 309 2.3E-13 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 Hamap MF_00711 Glycine dehydrogenase (decarboxylating) [gcvP]. 5 953 24.315 T 21-04-2016 IPR003437 Glycine dehydrogenase (decarboxylating) GO:0004375|GO:0006544|GO:0055114 KEGG: 00260+1.4.4.2 SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 SUPERFAMILY SSF53383 474 883 1.39E-92 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS10280 8dfc10197155a8f99d88e7cdb37d37f8 960 TIGRFAM TIGR00461 gcvP: glycine dehydrogenase 14 947 0.0 T 21-04-2016 IPR003437 Glycine dehydrogenase (decarboxylating) GO:0004375|GO:0006544|GO:0055114 KEGG: 00260+1.4.4.2 SPH21_RS05645 2e8a2ee4a783d8a4b8d6c5907f0c2998 331 Gene3D G3DSA:3.40.50.970 5 324 1.3E-140 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS05645 2e8a2ee4a783d8a4b8d6c5907f0c2998 331 PANTHER PTHR11516 6 323 1.8E-166 T 21-04-2016 SPH21_RS05645 2e8a2ee4a783d8a4b8d6c5907f0c2998 331 Pfam PF00676 Dehydrogenase E1 component 17 313 9.3E-98 T 21-04-2016 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 SPH21_RS05645 2e8a2ee4a783d8a4b8d6c5907f0c2998 331 SUPERFAMILY SSF52518 6 323 1.47E-108 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS05645 2e8a2ee4a783d8a4b8d6c5907f0c2998 331 TIGRFAM TIGR03182 PDH_E1_alph_y: pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit 9 322 7.4E-146 T 21-04-2016 IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y GO:0004739|GO:0006086|GO:0043231 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SPH21_RS09705 d21fb7966b961a97f2a7adcf466fad84 389 Pfam PF16344 Domain of unknown function (DUF4974) 287 385 7.9E-20 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS09705 d21fb7966b961a97f2a7adcf466fad84 389 Pfam PF04773 FecR protein 181 276 1.4E-19 T 21-04-2016 IPR006860 FecR protein SPH21_RS09705 d21fb7966b961a97f2a7adcf466fad84 389 PANTHER PTHR30273 183 389 5.5E-69 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09705 d21fb7966b961a97f2a7adcf466fad84 389 PANTHER PTHR30273 2 126 5.5E-69 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS09705 d21fb7966b961a97f2a7adcf466fad84 389 PANTHER PTHR30273:SF2 183 389 5.5E-69 T 21-04-2016 SPH21_RS09705 d21fb7966b961a97f2a7adcf466fad84 389 PANTHER PTHR30273:SF2 2 126 5.5E-69 T 21-04-2016 SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 PANTHER PTHR10992 6 286 1.3E-125 T 21-04-2016 SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 Gene3D G3DSA:3.40.50.1820 5 287 2.7E-60 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 SUPERFAMILY SSF53474 3 286 1.3E-66 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 Pfam PF00561 alpha/beta hydrolase fold 29 271 1.4E-27 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 PANTHER PTHR10992:SF26 6 286 1.3E-125 T 21-04-2016 SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 PRINTS PR00412 Epoxide hydrolase signature 261 283 7.6E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 PRINTS PR00412 Epoxide hydrolase signature 115 128 7.6E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS21515 f32a8ed14da0dc9cb8ad62aa218e5146 289 PRINTS PR00412 Epoxide hydrolase signature 35 53 7.6E-6 T 21-04-2016 IPR000639 Epoxide hydrolase-like GO:0003824 SPH21_RS09930 d2553be67dee55ad9459db91c43c4138 510 TIGRFAM TIGR03517 GldM_gliding: gliding motility-associated protein GldM 1 506 5.0E-112 T 21-04-2016 IPR019859 Gliding motility-associated protein GldM SPH21_RS09930 d2553be67dee55ad9459db91c43c4138 510 Pfam PF12081 GldM N-terminal domain 32 217 1.7E-51 T 21-04-2016 IPR022720 Gliding motility-associated protein GldM, N-terminal SPH21_RS09930 d2553be67dee55ad9459db91c43c4138 510 Pfam PF12080 GldM C-terminal domain 323 495 1.0E-48 T 21-04-2016 IPR022719 Gliding motility-associated protein GldM, C-terminal SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PRINTS PR00113 Alkaline phosphatase signature 96 111 2.2E-35 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PRINTS PR00113 Alkaline phosphatase signature 177 187 2.2E-35 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PRINTS PR00113 Alkaline phosphatase signature 133 153 2.2E-35 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PRINTS PR00113 Alkaline phosphatase signature 256 285 2.2E-35 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PRINTS PR00113 Alkaline phosphatase signature 40 60 2.2E-35 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 SUPERFAMILY SSF53649 418 466 1.09E-99 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 SUPERFAMILY SSF53649 22 347 1.09E-99 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PANTHER PTHR11596 24 401 1.5E-99 T 21-04-2016 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PANTHER PTHR11596 418 467 1.5E-99 T 21-04-2016 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 Pfam PF00245 Alkaline phosphatase 40 463 1.6E-69 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PANTHER PTHR11596:SF5 24 401 1.5E-99 T 21-04-2016 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 PANTHER PTHR11596:SF5 418 467 1.5E-99 T 21-04-2016 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 SMART SM00098 41 468 4.4E-32 T 21-04-2016 IPR001952 Alkaline phosphatase GO:0008152|GO:0016791 KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS14410 f0f3d344e1e9294ff2d68e34b8db31d1 469 Gene3D G3DSA:3.40.720.10 24 467 9.7E-106 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS09155 881d396888b9fd8cdba1878ee31f0f51 445 SUPERFAMILY SSF48452 16 443 2.66E-58 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09155 881d396888b9fd8cdba1878ee31f0f51 445 Gene3D G3DSA:1.25.40.10 203 385 1.5E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09155 881d396888b9fd8cdba1878ee31f0f51 445 Pfam PF07980 SusD family 314 402 1.9E-12 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09155 881d396888b9fd8cdba1878ee31f0f51 445 Pfam PF14322 Starch-binding associating with outer membrane 20 218 2.4E-32 T 21-04-2016 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 PANTHER PTHR11019:SF80 49 301 1.2E-41 T 21-04-2016 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 270 285 4.1E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 285 301 4.1E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 SUPERFAMILY SSF51215 55 113 1.57E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 Gene3D G3DSA:1.10.10.60 256 301 3.1E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 SUPERFAMILY SSF46689 257 301 2.64E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 Pfam PF12833 Helix-turn-helix domain 224 301 3.8E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 PANTHER PTHR11019 49 301 1.2E-41 T 21-04-2016 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 SMART SM00342 218 301 2.0E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26390 d149fa9930e8c55edcf19319d1dbcc0b 302 Gene3D G3DSA:2.60.120.280 55 96 3.9E-4 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS13010 ff885b699818cf3ef51fb60e0899e734 261 SUPERFAMILY SSF52833 41 258 1.3E-59 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS13010 ff885b699818cf3ef51fb60e0899e734 261 PANTHER PTHR36057 38 261 1.2E-40 T 21-04-2016 SPH21_RS13010 ff885b699818cf3ef51fb60e0899e734 261 Pfam PF06764 Protein of unknown function (DUF1223) 46 243 5.7E-63 T 21-04-2016 IPR010634 Protein of unknown function DUF1223 SPH21_RS13010 ff885b699818cf3ef51fb60e0899e734 261 Gene3D G3DSA:3.40.30.10 50 161 8.5E-4 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS13010 ff885b699818cf3ef51fb60e0899e734 261 PANTHER PTHR36057:SF1 38 261 1.2E-40 T 21-04-2016 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Pfam PF02817 e3 binding domain 255 290 7.7E-16 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 SUPERFAMILY SSF52777 324 547 4.89E-85 T 21-04-2016 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Pfam PF00364 Biotin-requiring enzyme 4 76 4.8E-19 T 21-04-2016 IPR000089 Biotin/lipoyl attachment SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Pfam PF00364 Biotin-requiring enzyme 130 201 2.5E-19 T 21-04-2016 IPR000089 Biotin/lipoyl attachment SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 SUPERFAMILY SSF51230 3 86 7.2E-26 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 PANTHER PTHR23151 23 547 1.0E-190 T 21-04-2016 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 SUPERFAMILY SSF51230 128 218 2.62E-24 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 324 547 2.7E-89 T 21-04-2016 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Gene3D G3DSA:2.40.50.100 2 86 9.5E-30 T 21-04-2016 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Gene3D G3DSA:2.40.50.100 128 222 1.3E-28 T 21-04-2016 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 SUPERFAMILY SSF47005 249 293 4.05E-11 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 PANTHER PTHR23151:SF9 23 547 1.0E-190 T 21-04-2016 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Gene3D G3DSA:3.30.559.10 316 547 5.3E-91 T 21-04-2016 IPR023213 Chloramphenicol acetyltransferase-like domain SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 153 182 - T 21-04-2016 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 27 56 - T 21-04-2016 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 TIGRFAM TIGR01349 PDHac_trf_mito: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase 131 548 1.2E-136 T 21-04-2016 IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex GO:0004742|GO:0006090|GO:0045254 KEGG: 00010+2.3.1.12|KEGG: 00020+2.3.1.12|KEGG: 00620+2.3.1.12 SPH21_RS05650 3c4e00c9ed27a08e69bb998164359f9c 548 Gene3D G3DSA:4.10.320.10 250 299 8.8E-19 T 21-04-2016 IPR004167 E3-binding domain GO:0008152|GO:0016746 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 TIGRFAM TIGR03396 PC_PLC: phospholipase C, phosphocholine-specific 3 845 9.3E-229 T 21-04-2016 IPR017767 Bacterial phospholipase C, phosphocholine-specific GO:0034480 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 PANTHER PTHR31956:SF6 384 471 1.1E-94 T 21-04-2016 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 PANTHER PTHR31956:SF6 494 568 1.1E-94 T 21-04-2016 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 PANTHER PTHR31956:SF6 2 285 1.1E-94 T 21-04-2016 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 Pfam PF05506 Domain of unknown function (DUF756) 636 738 6.9E-15 T 21-04-2016 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 Pfam PF04185 Phosphoesterase family 46 275 3.2E-49 T 21-04-2016 IPR007312 Phosphoesterase GO:0016788 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 Pfam PF04185 Phosphoesterase family 304 538 7.5E-41 T 21-04-2016 IPR007312 Phosphoesterase GO:0016788 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 PANTHER PTHR31956 384 471 1.1E-94 T 21-04-2016 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 PANTHER PTHR31956 494 568 1.1E-94 T 21-04-2016 SPH21_RS03285 238089ea27be986c725a57f90c44fc50 849 PANTHER PTHR31956 2 285 1.1E-94 T 21-04-2016 SPH21_RS23915 16ef8e4b26bfa92c362f11a37b2c3ec1 296 Pfam PF12833 Helix-turn-helix domain 204 282 3.3E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23915 16ef8e4b26bfa92c362f11a37b2c3ec1 296 SUPERFAMILY SSF46689 238 282 6.27E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23915 16ef8e4b26bfa92c362f11a37b2c3ec1 296 PANTHER PTHR11019 23 289 1.6E-33 T 21-04-2016 SPH21_RS23915 16ef8e4b26bfa92c362f11a37b2c3ec1 296 PANTHER PTHR11019:SF45 23 289 1.6E-33 T 21-04-2016 SPH21_RS23915 16ef8e4b26bfa92c362f11a37b2c3ec1 296 Gene3D G3DSA:1.10.10.60 238 283 4.0E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23915 16ef8e4b26bfa92c362f11a37b2c3ec1 296 SMART SM00342 198 281 1.1E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS16795 18a633caa173db993e98ab3b9885f4a2 482 Pfam PF01120 Alpha-L-fucosidase 20 380 2.4E-96 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS16795 18a633caa173db993e98ab3b9885f4a2 482 Pfam PF16757 Alpha-L-fucosidase C-terminal domain 394 477 1.4E-8 T 21-04-2016 IPR031919 Alpha-L-fucosidase, C-terminal KEGG: 00511+3.2.1.51 SPH21_RS16795 18a633caa173db993e98ab3b9885f4a2 482 SMART SM00812 27 423 5.2E-99 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS16795 18a633caa173db993e98ab3b9885f4a2 482 SUPERFAMILY SSF51445 34 383 3.79E-92 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS16795 18a633caa173db993e98ab3b9885f4a2 482 PIRSF PIRSF001092 3 468 6.0E-112 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS16795 18a633caa173db993e98ab3b9885f4a2 482 PANTHER PTHR10030 42 412 7.4E-53 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS16795 18a633caa173db993e98ab3b9885f4a2 482 Gene3D G3DSA:3.20.20.80 33 383 3.8E-97 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS13295 79ce4a6d04ac90ef11fa1be22e3d048f 213 SUPERFAMILY SSF54534 69 209 2.81E-16 T 21-04-2016 SPH21_RS13295 79ce4a6d04ac90ef11fa1be22e3d048f 213 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 104 206 9.1E-12 T 21-04-2016 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SPH21_RS13295 79ce4a6d04ac90ef11fa1be22e3d048f 213 Gene3D G3DSA:3.10.50.40 40 211 1.8E-27 T 21-04-2016 SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 PANTHER PTHR31964 1 139 6.2E-13 T 21-04-2016 SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 SUPERFAMILY SSF52402 1 149 1.76E-21 T 21-04-2016 SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 Pfam PF00582 Universal stress protein family 1 138 4.4E-15 T 21-04-2016 IPR006016 UspA GO:0006950 SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 PANTHER PTHR31964:SF45 1 139 6.2E-13 T 21-04-2016 SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 Gene3D G3DSA:3.40.50.620 1 139 1.3E-22 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 PRINTS PR01438 Universal stress protein signature 116 138 3.6E-10 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 PRINTS PR01438 Universal stress protein signature 1 19 3.6E-10 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 PRINTS PR01438 Universal stress protein signature 99 111 3.6E-10 T 21-04-2016 IPR006015 Universal stress protein A SPH21_RS13410 574621d5954978d72d8965cf7591227b 271 SUPERFAMILY SSF52402 146 270 1.34E-7 T 21-04-2016 SPH21_RS17490 946c2038285f5263c6c47f21d847a3c1 181 Gene3D G3DSA:1.20.1200.10 13 180 1.8E-63 T 21-04-2016 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 SPH21_RS17490 946c2038285f5263c6c47f21d847a3c1 181 ProDom PD007457 TRANSFERASE ADENOSYLTRANSFERASE COBALAMIN ATP:COBIALAMIN ADENOSYLTRANSFERASE PDUO TYPE RELATED ACIDURIA YVQK 9 179 3.0E-38 T 21-04-2016 IPR029499 ATP:cob(I)alamin adenosyltransferase, PduO-type KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|UniPathway: UPA00148 SPH21_RS17490 946c2038285f5263c6c47f21d847a3c1 181 Pfam PF01923 Cobalamin adenosyltransferase 3 166 1.1E-58 T 21-04-2016 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 SPH21_RS17490 946c2038285f5263c6c47f21d847a3c1 181 PANTHER PTHR12213 2 178 2.2E-76 T 21-04-2016 SPH21_RS17490 946c2038285f5263c6c47f21d847a3c1 181 TIGRFAM TIGR00636 PduO_Nterm: ATP:cob(I)alamin adenosyltransferase 4 179 4.7E-60 T 21-04-2016 IPR029499 ATP:cob(I)alamin adenosyltransferase, PduO-type KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|UniPathway: UPA00148 SPH21_RS17490 946c2038285f5263c6c47f21d847a3c1 181 SUPERFAMILY SSF89028 2 179 1.67E-61 T 21-04-2016 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 SPH21_RS04125 ce984239d6195c210cf553ed5eaeac1d 404 PIRSF PIRSF016719 1 404 4.4E-101 T 21-04-2016 IPR008302 Uncharacterised conserved protein UCP016719 SPH21_RS04125 ce984239d6195c210cf553ed5eaeac1d 404 PANTHER PTHR30480:SF3 6 404 2.1E-89 T 21-04-2016 SPH21_RS04125 ce984239d6195c210cf553ed5eaeac1d 404 Pfam PF07075 Protein of unknown function (DUF1343) 49 403 5.5E-118 T 21-04-2016 IPR008302 Uncharacterised conserved protein UCP016719 SPH21_RS04125 ce984239d6195c210cf553ed5eaeac1d 404 PANTHER PTHR30480 6 404 2.1E-89 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 SUPERFAMILY SSF56935 381 449 6.64E-83 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 SUPERFAMILY SSF56935 906 940 6.64E-83 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 SUPERFAMILY SSF56935 488 833 6.64E-83 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 SUPERFAMILY SSF56935 135 295 6.64E-83 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 Gene3D G3DSA:2.40.170.20 387 831 3.1E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532:SF51 43 219 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532:SF51 626 939 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532:SF51 237 496 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532:SF51 568 596 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532:SF51 957 1144 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 Gene3D G3DSA:2.170.130.10 134 274 1.3E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 SUPERFAMILY SSF49464 53 135 2.35E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 246 276 7.1E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 Pfam PF13715 CarboxypepD_reg-like domain 55 137 4.1E-16 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 54 1119 1.1E-186 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 Gene3D G3DSA:2.60.40.1120 55 115 1.4E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532 43 219 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532 626 939 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532 237 496 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532 568 596 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 PANTHER PTHR11532 957 1144 5.8E-155 T 21-04-2016 SPH21_RS09410 1754f01d7a23801a4bfe82e55945a3af 1146 Pfam PF07715 TonB-dependent Receptor Plug Domain 147 270 2.0E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00025 c973983a7181c3f56cf444b8db9ae001 117 ProSitePatterns PS01152 Hypothetical hesB/yadR/yfhF family signature. 98 115 - T 21-04-2016 IPR017870 FeS cluster insertion, C-terminal, conserved site SPH21_RS00025 c973983a7181c3f56cf444b8db9ae001 117 TIGRFAM TIGR00049 TIGR00049: iron-sulfur cluster assembly accessory protein 12 116 1.2E-30 T 21-04-2016 IPR016092 FeS cluster insertion protein GO:0005198|GO:0016226|GO:0051536 SPH21_RS00025 c973983a7181c3f56cf444b8db9ae001 117 Gene3D G3DSA:2.60.300.12 11 106 1.3E-26 T 21-04-2016 IPR000361 FeS cluster biogenesis SPH21_RS00025 c973983a7181c3f56cf444b8db9ae001 117 PANTHER PTHR10072 12 116 1.2E-33 T 21-04-2016 SPH21_RS00025 c973983a7181c3f56cf444b8db9ae001 117 Pfam PF01521 Iron-sulphur cluster biosynthesis 12 112 1.5E-17 T 21-04-2016 IPR000361 FeS cluster biogenesis SPH21_RS00025 c973983a7181c3f56cf444b8db9ae001 117 SUPERFAMILY SSF89360 11 106 7.85E-25 T 21-04-2016 IPR000361 FeS cluster biogenesis SPH21_RS01250 a1891158d101e5f48e12c21f8dd0902c 87 Pfam PF01381 Helix-turn-helix 27 81 1.1E-5 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01250 a1891158d101e5f48e12c21f8dd0902c 87 SMART SM00530 26 81 3.0E-4 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01250 a1891158d101e5f48e12c21f8dd0902c 87 Gene3D G3DSA:1.10.260.40 17 84 1.4E-11 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS01250 a1891158d101e5f48e12c21f8dd0902c 87 SUPERFAMILY SSF47413 15 83 2.96E-10 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 Gene3D G3DSA:3.40.50.720 1 151 3.9E-33 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 Gene3D G3DSA:1.10.1040.20 155 251 1.5E-33 T 21-04-2016 IPR018931 Domain of unknown function DUF2520 SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 PANTHER PTHR40459 1 245 5.5E-16 T 21-04-2016 SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 3 88 3.8E-10 T 21-04-2016 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 PANTHER PTHR40459:SF1 1 245 5.5E-16 T 21-04-2016 SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 SUPERFAMILY SSF48179 158 256 2.62E-26 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 SUPERFAMILY SSF51735 3 156 4.82E-27 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15630 bf5ca15286f26938c8422f778010a357 263 Pfam PF10728 Domain of unknown function (DUF2520) 126 248 1.9E-28 T 21-04-2016 IPR018931 Domain of unknown function DUF2520 SPH21_RS25620 82518fbdda355d22209b78aae511b029 296 Hamap MF_00361 NAD kinase [nadK]. 1 289 28.528 T 21-04-2016 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS25620 82518fbdda355d22209b78aae511b029 296 Gene3D G3DSA:2.60.200.30 156 265 5.4E-41 T 21-04-2016 IPR017437 ATP-NAD kinase, PpnK-type, all-beta GO:0003951|GO:0008152|GO:0019674 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS25620 82518fbdda355d22209b78aae511b029 296 PANTHER PTHR20275 1 291 3.0E-72 T 21-04-2016 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS25620 82518fbdda355d22209b78aae511b029 296 Pfam PF01513 ATP-NAD kinase 62 274 2.4E-52 T 21-04-2016 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS25620 82518fbdda355d22209b78aae511b029 296 SUPERFAMILY SSF111331 2 292 7.06E-74 T 21-04-2016 IPR016064 NAD kinase/diacylglycerol kinase-like domain SPH21_RS25620 82518fbdda355d22209b78aae511b029 296 Gene3D G3DSA:3.40.50.10330 1 155 1.1E-28 T 21-04-2016 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 PIRSF PIRSF000726 1 396 2.2E-65 T 21-04-2016 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 SUPERFAMILY SSF53633 1 292 5.11E-70 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 Gene3D G3DSA:3.40.1160.10 1 48 4.9E-53 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 Gene3D G3DSA:3.40.1160.10 101 294 4.9E-53 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 PANTHER PTHR21499:SF3 3 386 8.4E-76 T 21-04-2016 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 Pfam PF00696 Amino acid kinase family 2 279 3.5E-45 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 TIGRFAM TIGR00657 asp_kinases: aspartate kinase 3 386 1.6E-78 T 21-04-2016 IPR001341 Aspartate kinase domain GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 PANTHER PTHR21499 3 386 8.4E-76 T 21-04-2016 SPH21_RS23050 a4e6108644b8ac5b5a257fbdbe5fe702 422 SUPERFAMILY SSF55021 298 386 2.03E-7 T 21-04-2016 SPH21_RS25610 319154a3ac23cbe9c44c7a042d6daa9e 246 Gene3D G3DSA:3.40.1180.10 5 245 1.8E-97 T 21-04-2016 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 SPH21_RS25610 319154a3ac23cbe9c44c7a042d6daa9e 246 SUPERFAMILY SSF64005 7 234 1.02E-86 T 21-04-2016 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 SPH21_RS25610 319154a3ac23cbe9c44c7a042d6daa9e 246 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 12 239 6.5E-86 T 21-04-2016 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 SPH21_RS25610 319154a3ac23cbe9c44c7a042d6daa9e 246 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 12 240 39.399 T 21-04-2016 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 SPH21_RS25610 319154a3ac23cbe9c44c7a042d6daa9e 246 Pfam PF01255 Putative undecaprenyl diphosphate synthase 19 239 8.2E-80 T 21-04-2016 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 SPH21_RS25610 319154a3ac23cbe9c44c7a042d6daa9e 246 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 185 202 - T 21-04-2016 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 SPH21_RS25610 319154a3ac23cbe9c44c7a042d6daa9e 246 PANTHER PTHR10291 4 239 5.5E-122 T 21-04-2016 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 Gene3D G3DSA:1.10.10.10 118 182 1.8E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 SUPERFAMILY SSF88946 4 102 4.32E-14 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 Pfam PF08281 Sigma-70, region 4 124 176 1.1E-14 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 PANTHER PTHR30173 1 192 7.3E-38 T 21-04-2016 SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 178 1.4E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 PANTHER PTHR30173:SF20 1 192 7.3E-38 T 21-04-2016 SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 Gene3D G3DSA:1.10.1740.10 3 110 1.4E-14 T 21-04-2016 SPH21_RS23155 595f223a36df54a23a21bf07f40b6a51 193 SUPERFAMILY SSF88659 124 185 1.02E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 PANTHER PTHR12143:SF22 5 735 2.5E-215 T 21-04-2016 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 22 735 5.7E-212 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 SUPERFAMILY SSF48208 274 722 2.38E-38 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 PANTHER PTHR12143 5 735 2.5E-215 T 21-04-2016 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 Gene3D G3DSA:3.30.2080.10 596 742 7.3E-65 T 21-04-2016 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 Pfam PF07971 Glycosyl hydrolase family 92 246 731 9.6E-166 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 Gene3D G3DSA:2.70.98.10 26 326 4.0E-98 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 Gene3D G3DSA:1.20.1610.10 441 595 1.6E-63 T 21-04-2016 SPH21_RS11975 7afbe667db4fccf4022dc76e41961c9d 752 Gene3D G3DSA:1.20.1050.60 351 439 5.9E-32 T 21-04-2016 SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PANTHER PTHR24322 166 198 4.3E-63 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PANTHER PTHR24322 20 150 4.3E-63 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 Gene3D G3DSA:3.40.50.720 9 280 1.7E-69 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 SUPERFAMILY SSF51735 14 262 1.2E-66 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 185 1.8E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 92 103 1.8E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 187 204 1.8E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 1.8E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 224 244 1.8E-27 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 25 259 1.4E-47 T 21-04-2016 SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PANTHER PTHR24322:SF562 166 198 4.3E-63 T 21-04-2016 SPH21_RS07405 e0f7484f0e878b19cb242cde79f5a81c 292 PANTHER PTHR24322:SF562 20 150 4.3E-63 T 21-04-2016 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 PANTHER PTHR11019:SF45 55 285 3.1E-36 T 21-04-2016 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 SMART SM00342 203 284 4.2E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 Gene3D G3DSA:1.10.10.60 241 286 7.5E-18 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 253 268 1.1E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 268 284 1.1E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 Pfam PF12833 Helix-turn-helix domain 209 285 6.2E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 PANTHER PTHR11019 55 285 3.1E-36 T 21-04-2016 SPH21_RS04055 87b09770124d2c03bbf027e145ad0d6f 289 SUPERFAMILY SSF46689 240 287 1.57E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16545 a3028ee2019fc319475c92878d10d5b1 298 SMART SM00046 4 126 3.1E-4 T 21-04-2016 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SPH21_RS16545 a3028ee2019fc319475c92878d10d5b1 298 SUPERFAMILY SSF111331 4 297 1.22E-41 T 21-04-2016 IPR016064 NAD kinase/diacylglycerol kinase-like domain SPH21_RS16545 a3028ee2019fc319475c92878d10d5b1 298 PANTHER PTHR12358 52 298 6.4E-20 T 21-04-2016 SPH21_RS16545 a3028ee2019fc319475c92878d10d5b1 298 Pfam PF00781 Diacylglycerol kinase catalytic domain 5 122 5.8E-19 T 21-04-2016 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SPH21_RS16545 a3028ee2019fc319475c92878d10d5b1 298 Gene3D G3DSA:3.40.50.10330 3 115 1.3E-5 T 21-04-2016 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS17650 90371cee7c85b8d7a521b6efed56bcbe 406 Pfam PF02687 FtsX-like permease family 274 399 8.5E-15 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS17650 90371cee7c85b8d7a521b6efed56bcbe 406 PANTHER PTHR30489 19 406 4.3E-45 T 21-04-2016 SPH21_RS17650 90371cee7c85b8d7a521b6efed56bcbe 406 Pfam PF12704 MacB-like periplasmic core domain 27 192 7.8E-12 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 Pfam PF03466 LysR substrate binding domain 88 291 2.2E-34 T 21-04-2016 IPR005119 LysR, substrate-binding SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 Gene3D G3DSA:1.10.10.10 1 85 2.3E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 1.3E-15 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 Gene3D G3DSA:3.40.190.10 88 178 7.4E-20 T 21-04-2016 SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 Gene3D G3DSA:3.40.190.10 179 260 1.4E-13 T 21-04-2016 SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 PANTHER PTHR30126 1 292 1.2E-66 T 21-04-2016 SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 SUPERFAMILY SSF46785 1 111 1.04E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09460 78b54adc72ed589e2bf8127f788b6f10 301 SUPERFAMILY SSF53850 88 292 1.89E-36 T 21-04-2016 SPH21_RS23555 db051539356505971371cc46619a770a 72 Pfam PF00403 Heavy-metal-associated domain 11 67 1.2E-5 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS23555 db051539356505971371cc46619a770a 72 SUPERFAMILY SSF55008 8 70 2.88E-10 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS23555 db051539356505971371cc46619a770a 72 Gene3D G3DSA:3.30.70.100 9 71 3.0E-11 T 21-04-2016 SPH21_RS19625 1b2fb5fd67517aec6bbd5c63043c019d 96 SUPERFAMILY SSF102829 6 94 2.48E-14 T 21-04-2016 IPR007838 Cell division protein ZapA-like SPH21_RS19625 1b2fb5fd67517aec6bbd5c63043c019d 96 Pfam PF05164 Cell division protein ZapA 6 88 2.1E-17 T 21-04-2016 IPR007838 Cell division protein ZapA-like SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 PANTHER PTHR18937 1 1180 1.2E-196 T 21-04-2016 SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 TIGRFAM TIGR02168 SMC_prok_B: chromosome segregation protein SMC 2 1178 0.0 T 21-04-2016 IPR011890 Structural maintenance of chromosomes protein, prokaryotic GO:0007062|GO:0030261 SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 SMART SM00968 520 636 4.0E-6 T 21-04-2016 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 SUPERFAMILY SSF75553 485 685 2.88E-22 T 21-04-2016 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 PANTHER PTHR18937:SF261 1 1180 1.2E-196 T 21-04-2016 SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 Pfam PF06470 SMC proteins Flexible Hinge Domain 523 631 6.0E-13 T 21-04-2016 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 SUPERFAMILY SSF52540 1077 1163 8.04E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 SUPERFAMILY SSF52540 1 216 8.04E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 Hamap MF_01894 Chromosome partition protein Smc [smc]. 1 1180 21.024 T 21-04-2016 IPR011890 Structural maintenance of chromosomes protein, prokaryotic GO:0007062|GO:0030261 SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 Gene3D G3DSA:3.40.50.300 1 163 7.1E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 Gene3D G3DSA:3.40.50.300 1043 1180 7.1E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 Gene3D G3DSA:3.40.50.300 966 982 7.1E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 Pfam PF02463 RecF/RecN/SMC N terminal domain 3 1171 3.5E-61 T 21-04-2016 IPR003395 RecF/RecN/SMC, N-terminal SPH21_RS16305 1774fbcb6c7016357340c43fa05f7e15 1181 PIRSF PIRSF005719 1 1181 1.7E-253 T 21-04-2016 IPR024704 Structural maintenance of chromosomes protein SPH21_RS17310 4dc54d5af24b1d308ecd14ac5d836e05 228 Pfam PF01844 HNH endonuclease 21 61 1.8E-9 T 21-04-2016 IPR002711 HNH endonuclease GO:0003676|GO:0004519 SPH21_RS17310 4dc54d5af24b1d308ecd14ac5d836e05 228 SMART SM00507 8 57 4.7E-10 T 21-04-2016 IPR003615 HNH nuclease SPH21_RS17220 b69c574277310d7345c39055fd6b619b 392 Pfam PF13102 Phage integrase SAM-like domain 15 172 6.8E-23 T 21-04-2016 IPR025269 Phage integrase SAM-like domain SPH21_RS17220 b69c574277310d7345c39055fd6b619b 392 SUPERFAMILY SSF56349 128 384 7.06E-41 T 21-04-2016 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SPH21_RS17220 b69c574277310d7345c39055fd6b619b 392 Pfam PF00589 Phage integrase family 221 377 2.9E-13 T 21-04-2016 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS17220 b69c574277310d7345c39055fd6b619b 392 Gene3D G3DSA:1.10.443.10 218 388 6.0E-25 T 21-04-2016 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS17220 b69c574277310d7345c39055fd6b619b 392 Gene3D G3DSA:1.10.150.130 118 201 3.0E-8 T 21-04-2016 IPR023109 Integrase/recombinase, N-terminal SPH21_RS17220 b69c574277310d7345c39055fd6b619b 392 PANTHER PTHR30349:SF26 44 389 9.2E-42 T 21-04-2016 SPH21_RS17220 b69c574277310d7345c39055fd6b619b 392 PANTHER PTHR30349 44 389 9.2E-42 T 21-04-2016 SPH21_RS06095 9ebd727e72bf7a7d8bef53aaa5c4d770 238 SUPERFAMILY SSF63892 1 237 1.19E-86 T 21-04-2016 IPR004569 Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2|UniPathway: UPA00244 SPH21_RS06095 9ebd727e72bf7a7d8bef53aaa5c4d770 238 PANTHER PTHR30456 1 235 4.4E-115 T 21-04-2016 SPH21_RS06095 9ebd727e72bf7a7d8bef53aaa5c4d770 238 PANTHER PTHR30456:SF0 1 235 4.4E-115 T 21-04-2016 SPH21_RS06095 9ebd727e72bf7a7d8bef53aaa5c4d770 238 Pfam PF03740 Pyridoxal phosphate biosynthesis protein PdxJ 3 235 3.7E-94 T 21-04-2016 IPR004569 Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2|UniPathway: UPA00244 SPH21_RS06095 9ebd727e72bf7a7d8bef53aaa5c4d770 238 Gene3D G3DSA:3.20.20.70 1 237 1.3E-93 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS06095 9ebd727e72bf7a7d8bef53aaa5c4d770 238 TIGRFAM TIGR00559 pdxJ: pyridoxine 5'-phosphate synthase 3 237 2.5E-85 T 21-04-2016 IPR004569 Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2|UniPathway: UPA00244 SPH21_RS06095 9ebd727e72bf7a7d8bef53aaa5c4d770 238 Hamap MF_00279 Pyridoxine 5'-phosphate synthase [pdxJ]. 1 238 90.438 T 21-04-2016 IPR004569 Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ GO:0005737|GO:0008615|GO:0033856 KEGG: 00750+2.6.99.2|UniPathway: UPA00244 SPH21_RS02615 0ba48a4bbed4f40af9c285fe8c401722 175 Pfam PF05163 DinB family 17 173 3.3E-16 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS02615 0ba48a4bbed4f40af9c285fe8c401722 175 PANTHER PTHR37302 15 175 8.7E-12 T 21-04-2016 SPH21_RS02615 0ba48a4bbed4f40af9c285fe8c401722 175 SUPERFAMILY SSF109854 18 156 6.41E-22 T 21-04-2016 SPH21_RS02615 0ba48a4bbed4f40af9c285fe8c401722 175 Gene3D G3DSA:1.20.120.450 16 172 8.2E-24 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS02615 0ba48a4bbed4f40af9c285fe8c401722 175 PANTHER PTHR37302:SF2 15 175 8.7E-12 T 21-04-2016 SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 SUPERFAMILY SSF49464 41 139 3.37E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 Gene3D G3DSA:2.40.170.20 240 778 4.8E-28 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 Gene3D G3DSA:2.60.40.1120 42 135 1.7E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 Pfam PF13620 Carboxypeptidase regulatory-like domain 42 115 4.8E-13 T 21-04-2016 SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 Pfam PF14905 Outer membrane protein beta-barrel family 396 798 1.4E-111 T 21-04-2016 SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 Pfam PF07715 TonB-dependent Receptor Plug Domain 160 239 2.9E-4 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 SUPERFAMILY SSF56935 132 800 2.38E-52 T 21-04-2016 SPH21_RS19165 d99dc7cfc57a282b034ecde025da569f 822 Gene3D G3DSA:2.170.130.10 136 239 3.1E-9 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02740 fda22396577eb6fdce6f91a6c4de7433 269 Gene3D G3DSA:3.40.1010.10 17 131 4.6E-35 T 21-04-2016 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 SPH21_RS02740 fda22396577eb6fdce6f91a6c4de7433 269 SUPERFAMILY SSF53790 16 260 4.84E-55 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS02740 fda22396577eb6fdce6f91a6c4de7433 269 TIGRFAM TIGR01469 cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase 17 252 5.0E-68 T 21-04-2016 IPR006366 Uroporphyrin-III C-methyltransferase GO:0006779|GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377|UniPathway: UPA00148|UniPathway: UPA00148|UniPathway: UPA00262|UniPathway: UPA00262|UniPathway: UPA00262 SPH21_RS02740 fda22396577eb6fdce6f91a6c4de7433 269 PANTHER PTHR21091:SF16 17 226 1.2E-49 T 21-04-2016 SPH21_RS02740 fda22396577eb6fdce6f91a6c4de7433 269 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 17 223 4.2E-38 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS02740 fda22396577eb6fdce6f91a6c4de7433 269 Gene3D G3DSA:3.30.950.10 132 256 5.7E-23 T 21-04-2016 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 SPH21_RS02740 fda22396577eb6fdce6f91a6c4de7433 269 PANTHER PTHR21091 17 226 1.2E-49 T 21-04-2016 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Hamap MF_00204 UvrABC system protein B [uvrB]. 1 670 41.776 T 21-04-2016 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006281|GO:0006289|GO:0009381|GO:0009432 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Gene3D G3DSA:3.30.2060.10 161 237 6.0E-10 T 21-04-2016 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 SUPERFAMILY SSF46600 626 672 3.92E-8 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 SMART SM00487 7 424 1.0E-27 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Pfam PF12344 Ultra-violet resistance protein B 550 590 2.3E-22 T 21-04-2016 IPR024759 UvrB, YAD/RRR-motif-containing domain SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 SUPERFAMILY SSF52540 4 413 2.63E-124 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Gene3D G3DSA:3.40.50.300 276 336 3.4E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Gene3D G3DSA:3.40.50.300 386 407 3.4E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Gene3D G3DSA:3.40.50.300 5 87 3.4E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Gene3D G3DSA:4.10.860.10 625 672 5.4E-12 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Pfam PF02151 UvrB/uvrC motif 636 669 1.5E-6 T 21-04-2016 IPR001943 UVR domain GO:0005515 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 PANTHER PTHR24029 1 673 0.0 T 21-04-2016 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006281|GO:0006289|GO:0009381|GO:0009432 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 SMART SM00490 458 544 1.1E-20 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Pfam PF04851 Type III restriction enzyme, res subunit 13 89 3.3E-8 T 21-04-2016 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Gene3D G3DSA:3.40.50.300 424 581 3.4E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 Pfam PF00271 Helicase conserved C-terminal domain 431 543 5.0E-20 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 SUPERFAMILY SSF52540 457 582 3.77E-34 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 SUPERFAMILY SSF52540 35 80 3.77E-34 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03560 54f2a1c2ef2e8ed7b225e9177330251b 675 TIGRFAM TIGR00631 uvrb: excinuclease ABC subunit B 2 667 1.7E-303 T 21-04-2016 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006281|GO:0006289|GO:0009381|GO:0009432 SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 Pfam PF02709 N-terminal domain of galactosyltransferase 169 230 8.9E-15 T 21-04-2016 IPR027791 Galactosyltransferase, C-terminal UniPathway: UPA00378 SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 Gene3D G3DSA:3.90.550.10 3 263 9.8E-46 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 SUPERFAMILY SSF53448 2 213 1.59E-36 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 PANTHER PTHR22916:SF31 165 220 3.6E-34 T 21-04-2016 SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 PANTHER PTHR22916:SF31 5 143 3.6E-34 T 21-04-2016 SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 Pfam PF00535 Glycosyl transferase family 2 6 134 6.3E-21 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 PANTHER PTHR22916 165 220 3.6E-34 T 21-04-2016 SPH21_RS12045 094f6870afefbe0752fc40f93e536006 275 PANTHER PTHR22916 5 143 3.6E-34 T 21-04-2016 SPH21_RS04965 3faf6efc016649e21f6606bda9797092 619 Pfam PF16151 Domain of unknown function (DUF4859) 495 605 4.9E-36 T 21-04-2016 IPR032339 Domain of unknown function DUF4859 SPH21_RS11800 7b2ba6457250b5950d97fda414d21a50 244 Pfam PF10677 Protein of unknown function (DUF2490) 35 228 4.1E-48 T 21-04-2016 IPR019619 Protein of unknown function DUF2490 SPH21_RS22695 08639996fc7bf795c0eeaf5efaceb550 143 SUPERFAMILY SSF55961 4 140 2.95E-29 T 21-04-2016 SPH21_RS22695 08639996fc7bf795c0eeaf5efaceb550 143 Gene3D G3DSA:3.30.530.20 3 142 1.3E-33 T 21-04-2016 IPR023393 START-like domain SPH21_RS22695 08639996fc7bf795c0eeaf5efaceb550 143 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 14 139 7.1E-22 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS13790 816d17d77610a139789195f7b4e6e93a 416 Gene3D G3DSA:1.20.1250.20 223 411 3.5E-31 T 21-04-2016 SPH21_RS13790 816d17d77610a139789195f7b4e6e93a 416 PANTHER PTHR11662:SF3 9 411 3.8E-113 T 21-04-2016 SPH21_RS13790 816d17d77610a139789195f7b4e6e93a 416 Gene3D G3DSA:1.20.1250.20 11 204 8.8E-40 T 21-04-2016 SPH21_RS13790 816d17d77610a139789195f7b4e6e93a 416 Pfam PF07690 Major Facilitator Superfamily 17 375 2.8E-57 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS13790 816d17d77610a139789195f7b4e6e93a 416 SUPERFAMILY SSF103473 7 413 5.36E-82 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13790 816d17d77610a139789195f7b4e6e93a 416 PANTHER PTHR11662 9 411 3.8E-113 T 21-04-2016 SPH21_RS26460 259e42f4644d35bd69b140c4ef153a93 409 Pfam PF13899 Thioredoxin-like 34 113 7.6E-12 T 21-04-2016 SPH21_RS26460 259e42f4644d35bd69b140c4ef153a93 409 ProSitePatterns PS00194 Thioredoxin family active site. 49 67 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS26460 259e42f4644d35bd69b140c4ef153a93 409 Gene3D G3DSA:3.40.30.10 34 140 5.4E-27 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26460 259e42f4644d35bd69b140c4ef153a93 409 SUPERFAMILY SSF52833 18 142 3.05E-32 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 Gene3D G3DSA:1.10.10.60 231 282 6.2E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 Gene3D G3DSA:2.60.120.280 40 163 1.5E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 SUPERFAMILY SSF46689 235 280 8.24E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 PANTHER PTHR11019:SF80 41 272 3.5E-23 T 21-04-2016 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 Pfam PF12833 Helix-turn-helix domain 201 279 4.3E-20 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 SMART SM00342 195 279 1.3E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 SUPERFAMILY SSF51215 41 162 3.27E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 PANTHER PTHR11019 41 272 3.5E-23 T 21-04-2016 SPH21_RS24635 03338abd666ecd2c689a4d1590a2be60 284 Gene3D G3DSA:1.10.10.60 187 230 6.7E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00715 c43387a223e3a330366914b9ced1ab97 411 Pfam PF04235 Protein of unknown function (DUF418) 236 405 7.1E-32 T 21-04-2016 IPR007349 Domain of unknown function DUF418 SPH21_RS00715 c43387a223e3a330366914b9ced1ab97 411 PANTHER PTHR30590:SF2 1 411 3.9E-69 T 21-04-2016 SPH21_RS00715 c43387a223e3a330366914b9ced1ab97 411 PANTHER PTHR30590 1 411 3.9E-69 T 21-04-2016 SPH21_RS09420 ce2bf8e984333cb2f49e366243f95a85 449 Pfam PF10142 PhoPQ-activated pathogenicity-related protein 31 389 1.7E-104 T 21-04-2016 IPR009199 PhoPQ-activated pathogenicity-related protein, PqaA type SPH21_RS09420 ce2bf8e984333cb2f49e366243f95a85 449 Gene3D G3DSA:3.40.50.1820 78 340 6.4E-16 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS09420 ce2bf8e984333cb2f49e366243f95a85 449 PANTHER PTHR31497:SF0 1 444 1.9E-111 T 21-04-2016 SPH21_RS09420 ce2bf8e984333cb2f49e366243f95a85 449 PANTHER PTHR31497 1 444 1.9E-111 T 21-04-2016 SPH21_RS09420 ce2bf8e984333cb2f49e366243f95a85 449 PIRSF PIRSF014728 25 445 2.1E-76 T 21-04-2016 IPR009199 PhoPQ-activated pathogenicity-related protein, PqaA type SPH21_RS09420 ce2bf8e984333cb2f49e366243f95a85 449 SUPERFAMILY SSF53474 161 245 1.15E-12 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS09420 ce2bf8e984333cb2f49e366243f95a85 449 SUPERFAMILY SSF53474 274 343 1.15E-12 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS18505 07abdbb42325663a863732a9544f9991 195 Pfam PF13875 Domain of unknown function (DUF4202) 6 185 3.3E-60 T 21-04-2016 IPR025255 Protein of unknown function DUF4202 SPH21_RS18505 07abdbb42325663a863732a9544f9991 195 SUPERFAMILY SSF109604 92 165 3.09E-5 T 21-04-2016 SPH21_RS18505 07abdbb42325663a863732a9544f9991 195 SUPERFAMILY SSF109604 35 54 3.09E-5 T 21-04-2016 SPH21_RS18505 07abdbb42325663a863732a9544f9991 195 PANTHER PTHR41729:SF1 1 194 1.1E-46 T 21-04-2016 SPH21_RS18505 07abdbb42325663a863732a9544f9991 195 PANTHER PTHR41729 1 194 1.1E-46 T 21-04-2016 SPH21_RS21250 49d47e774256c3bf63c76d51cfab162e 310 Pfam PF16344 Domain of unknown function (DUF4974) 211 308 1.0E-12 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS21250 49d47e774256c3bf63c76d51cfab162e 310 PANTHER PTHR30273 4 310 3.6E-48 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21250 49d47e774256c3bf63c76d51cfab162e 310 PIRSF PIRSF018266 1 310 5.6E-51 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21250 49d47e774256c3bf63c76d51cfab162e 310 Pfam PF04773 FecR protein 103 195 8.1E-20 T 21-04-2016 IPR006860 FecR protein SPH21_RS21250 49d47e774256c3bf63c76d51cfab162e 310 PANTHER PTHR30273:SF2 4 310 3.6E-48 T 21-04-2016 SPH21_RS11135 27f622936ae9afe82675212131959d3a 193 SUPERFAMILY SSF109604 2 187 3.31E-27 T 21-04-2016 SPH21_RS11135 27f622936ae9afe82675212131959d3a 193 Gene3D G3DSA:1.10.3210.10 4 128 2.4E-19 T 21-04-2016 IPR006674 HD domain SPH21_RS11135 27f622936ae9afe82675212131959d3a 193 SMART SM00471 22 138 6.4E-4 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS15150 bd88f81d3c6241cb510bd374b8a0503f 398 PANTHER PTHR22572 156 377 3.4E-22 T 21-04-2016 SPH21_RS15150 bd88f81d3c6241cb510bd374b8a0503f 398 Gene3D G3DSA:2.160.10.10 189 349 1.7E-13 T 21-04-2016 SPH21_RS15150 bd88f81d3c6241cb510bd374b8a0503f 398 TIGRFAM TIGR03991 alt_bact_glmU: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase 1 387 2.9E-107 T 21-04-2016 IPR023917 UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, bacterial-type SPH21_RS15150 bd88f81d3c6241cb510bd374b8a0503f 398 Pfam PF13562 Sugar nucleotidyl transferase 3 158 1.0E-41 T 21-04-2016 IPR023917 UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, bacterial-type SPH21_RS15150 bd88f81d3c6241cb510bd374b8a0503f 398 SUPERFAMILY SSF51161 189 357 2.55E-17 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS15150 bd88f81d3c6241cb510bd374b8a0503f 398 PANTHER PTHR22572:SF99 156 377 3.4E-22 T 21-04-2016 SPH21_RS09670 ffdfb3f85370ed8b80d8063b80f05ee0 257 Pfam PF10531 SLBB domain 143 189 8.3E-7 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS09670 ffdfb3f85370ed8b80d8063b80f05ee0 257 Gene3D G3DSA:3.10.560.10 136 223 2.9E-19 T 21-04-2016 SPH21_RS09670 ffdfb3f85370ed8b80d8063b80f05ee0 257 Gene3D G3DSA:3.30.1950.10 53 135 5.5E-17 T 21-04-2016 SPH21_RS09670 ffdfb3f85370ed8b80d8063b80f05ee0 257 PANTHER PTHR33619 91 254 5.8E-36 T 21-04-2016 SPH21_RS09670 ffdfb3f85370ed8b80d8063b80f05ee0 257 PANTHER PTHR33619 54 68 5.8E-36 T 21-04-2016 SPH21_RS09670 ffdfb3f85370ed8b80d8063b80f05ee0 257 Pfam PF02563 Polysaccharide biosynthesis/export protein 44 139 9.3E-18 T 21-04-2016 IPR003715 Polysaccharide export protein GO:0015159|GO:0015774|GO:0016020 SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 PANTHER PTHR24567 13 207 2.4E-28 T 21-04-2016 SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 Gene3D G3DSA:2.60.120.10 13 143 1.2E-25 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 Gene3D G3DSA:1.10.10.10 149 206 2.6E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 SMART SM00100 8 128 4.3E-5 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 Pfam PF13545 Crp-like helix-turn-helix domain 149 206 7.9E-11 T 21-04-2016 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 Pfam PF00027 Cyclic nucleotide-binding domain 27 115 1.5E-9 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 SUPERFAMILY SSF46785 146 206 4.68E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17850 a04b3f5135299b7fa2f9dd9d2fa28be0 207 SUPERFAMILY SSF51206 13 143 1.11E-24 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS18065 6f1e0a1f226b5e90288a90774dff6482 407 PANTHER PTHR11532:SF57 334 405 6.9E-19 T 21-04-2016 SPH21_RS18065 6f1e0a1f226b5e90288a90774dff6482 407 PANTHER PTHR11532 334 405 6.9E-19 T 21-04-2016 SPH21_RS18065 6f1e0a1f226b5e90288a90774dff6482 407 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 375 405 1.5E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS18065 6f1e0a1f226b5e90288a90774dff6482 407 Pfam PF07715 TonB-dependent Receptor Plug Domain 328 399 4.6E-9 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18065 6f1e0a1f226b5e90288a90774dff6482 407 Gene3D G3DSA:2.170.130.10 327 405 8.6E-10 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18065 6f1e0a1f226b5e90288a90774dff6482 407 SUPERFAMILY SSF56935 328 405 4.49E-10 T 21-04-2016 SPH21_RS18065 6f1e0a1f226b5e90288a90774dff6482 407 Pfam PF05569 BlaR1 peptidase M56 65 253 1.5E-14 T 21-04-2016 IPR008756 Peptidase M56 SPH21_RS16905 48b7bb6e0cc99cdae199ffd0e54b9100 229 SUPERFAMILY SSF46785 1 61 1.44E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16905 48b7bb6e0cc99cdae199ffd0e54b9100 229 Pfam PF08279 HTH domain 6 58 2.1E-13 T 21-04-2016 IPR013196 Helix-turn-helix, type 11 SPH21_RS16905 48b7bb6e0cc99cdae199ffd0e54b9100 229 Pfam PF13280 WYL domain 137 214 3.9E-15 T 21-04-2016 IPR026881 WYL domain SPH21_RS16905 48b7bb6e0cc99cdae199ffd0e54b9100 229 PANTHER PTHR34580:SF3 1 225 8.6E-42 T 21-04-2016 SPH21_RS16905 48b7bb6e0cc99cdae199ffd0e54b9100 229 Gene3D G3DSA:1.10.10.10 1 62 1.7E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16905 48b7bb6e0cc99cdae199ffd0e54b9100 229 PANTHER PTHR34580 1 225 8.6E-42 T 21-04-2016 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 Pfam PF04542 Sigma-70 region 2 29 94 2.4E-10 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 SUPERFAMILY SSF88659 121 185 2.01E-10 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 PANTHER PTHR30173:SF20 1 195 5.3E-37 T 21-04-2016 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 Pfam PF08281 Sigma-70, region 4 127 175 3.7E-8 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 PANTHER PTHR30173 1 195 5.3E-37 T 21-04-2016 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 SUPERFAMILY SSF88946 9 102 6.8E-21 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 Gene3D G3DSA:1.10.10.10 120 181 3.8E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 24 179 7.5E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21255 8fb682f1e825545be8ad70e658aa6075 200 Gene3D G3DSA:1.10.1740.10 9 106 2.9E-22 T 21-04-2016 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 SUPERFAMILY SSF81330 12 122 6.41E-31 T 21-04-2016 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 TIGRFAM TIGR00220 mscL: large conductance mechanosensitive channel protein 3 127 8.1E-42 T 21-04-2016 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 79 87 4.2E-13 T 21-04-2016 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 88 97 4.2E-13 T 21-04-2016 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 6 20 4.2E-13 T 21-04-2016 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 Pfam PF01741 Large-conductance mechanosensitive channel, MscL 3 126 2.8E-41 T 21-04-2016 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 PANTHER PTHR30266:SF2 1 126 9.4E-47 T 21-04-2016 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 PANTHER PTHR30266 1 126 9.4E-47 T 21-04-2016 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 Hamap MF_00115 Large-conductance mechanosensitive channel [mscL]. 3 129 25.473 T 21-04-2016 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SPH21_RS01605 6371a48467c5dc8d22b0e25e0c6c8348 129 ProSitePatterns PS01327 Large-conductance mechanosensitive channels mscL family signature. 13 26 - T 21-04-2016 IPR019823 Large-conductance mechanosensitive channel, conserved site SPH21_RS08825 2f5abc1ffeb9a55644b82188ecede84f 168 Gene3D G3DSA:3.90.550.10 2 145 7.3E-21 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08825 2f5abc1ffeb9a55644b82188ecede84f 168 Pfam PF00535 Glycosyl transferase family 2 9 118 1.3E-14 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS08825 2f5abc1ffeb9a55644b82188ecede84f 168 SUPERFAMILY SSF53448 3 143 2.59E-22 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08825 2f5abc1ffeb9a55644b82188ecede84f 168 PANTHER PTHR22916 1 127 4.1E-19 T 21-04-2016 SPH21_RS21315 208d42c283d54906df096ee913d7fb95 460 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 33 222 2.1E-13 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21315 208d42c283d54906df096ee913d7fb95 460 SUPERFAMILY SSF52266 22 231 6.33E-36 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21315 208d42c283d54906df096ee913d7fb95 460 Gene3D G3DSA:3.40.50.1110 29 231 4.0E-27 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21315 208d42c283d54906df096ee913d7fb95 460 PANTHER PTHR30383:SF6 18 460 5.3E-82 T 21-04-2016 SPH21_RS21315 208d42c283d54906df096ee913d7fb95 460 PANTHER PTHR30383 18 460 5.3E-82 T 21-04-2016 SPH21_RS09205 783518ba123ccb5f75305c12abb9d863 99 Gene3D G3DSA:3.40.1440.10 6 43 4.2E-4 T 21-04-2016 IPR027299 GIY-YIG domain SPH21_RS09205 783518ba123ccb5f75305c12abb9d863 99 SUPERFAMILY SSF82771 6 92 6.41E-18 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS09205 783518ba123ccb5f75305c12abb9d863 99 PANTHER PTHR34477 7 96 2.0E-25 T 21-04-2016 SPH21_RS09205 783518ba123ccb5f75305c12abb9d863 99 SMART SM00465 3 84 1.1E-6 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS09205 783518ba123ccb5f75305c12abb9d863 99 Pfam PF01541 GIY-YIG catalytic domain 5 78 3.5E-14 T 21-04-2016 IPR000305 GIY-YIG nuclease superfamily SPH21_RS09205 783518ba123ccb5f75305c12abb9d863 99 PANTHER PTHR34477:SF2 7 96 2.0E-25 T 21-04-2016 SPH21_RS13910 238aa21a48132ea1ebd04b3a203088c4 246 PANTHER PTHR15032:SF18 23 245 3.1E-28 T 21-04-2016 SPH21_RS13910 238aa21a48132ea1ebd04b3a203088c4 246 Pfam PF13483 Beta-lactamase superfamily domain 32 210 2.0E-22 T 21-04-2016 SPH21_RS13910 238aa21a48132ea1ebd04b3a203088c4 246 Gene3D G3DSA:3.60.15.10 21 215 4.8E-39 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS13910 238aa21a48132ea1ebd04b3a203088c4 246 PANTHER PTHR15032 23 245 3.1E-28 T 21-04-2016 SPH21_RS13910 238aa21a48132ea1ebd04b3a203088c4 246 SUPERFAMILY SSF56281 27 235 3.5E-26 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS06600 edc8fbecd159f41ae30d2053c6d951f4 213 PANTHER PTHR11935:SF8 1 212 3.0E-49 T 21-04-2016 SPH21_RS06600 edc8fbecd159f41ae30d2053c6d951f4 213 SUPERFAMILY SSF56281 15 212 3.11E-43 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS06600 edc8fbecd159f41ae30d2053c6d951f4 213 Pfam PF00753 Metallo-beta-lactamase superfamily 11 195 3.7E-22 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS06600 edc8fbecd159f41ae30d2053c6d951f4 213 PANTHER PTHR11935 1 212 3.0E-49 T 21-04-2016 SPH21_RS06600 edc8fbecd159f41ae30d2053c6d951f4 213 SMART SM00849 13 195 3.0E-26 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS06600 edc8fbecd159f41ae30d2053c6d951f4 213 Gene3D G3DSA:3.60.15.10 9 212 6.6E-48 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 PANTHER PTHR30572:SF4 274 348 1.5E-73 T 21-04-2016 SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 PANTHER PTHR30572:SF4 395 783 1.5E-73 T 21-04-2016 SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 Pfam PF12704 MacB-like periplasmic core domain 428 627 1.0E-6 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 Pfam PF12704 MacB-like periplasmic core domain 21 236 2.0E-18 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 Pfam PF02687 FtsX-like permease family 282 398 5.1E-17 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 Pfam PF02687 FtsX-like permease family 663 776 1.4E-8 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 PANTHER PTHR30572 274 348 1.5E-73 T 21-04-2016 SPH21_RS05780 70d50f95027829a6d13086c04583455a 783 PANTHER PTHR30572 395 783 1.5E-73 T 21-04-2016 SPH21_RS02760 2d9a555ee29139553b5b0b69bc1b0187 333 PANTHER PTHR28208 123 281 2.3E-32 T 21-04-2016 SPH21_RS02760 2d9a555ee29139553b5b0b69bc1b0187 333 Pfam PF09949 Uncharacterized conserved protein (DUF2183) 182 280 2.7E-30 T 21-04-2016 IPR019236 Domain of unknown function DUF2183 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PANTHER PTHR11390 1 488 8.9E-265 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PANTHER PTHR11390 518 615 8.9E-265 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 162 180 2.0E-34 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 353 369 2.0E-34 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 77 90 2.0E-34 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 281 290 2.0E-34 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 464 478 2.0E-34 T 21-04-2016 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 SMART SM00437 239 532 1.7E-92 T 21-04-2016 IPR003602 DNA topoisomerase, type IA, DNA-binding domain GO:0003677|GO:0003916|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 SMART SM00436 104 192 1.5E-46 T 21-04-2016 IPR003601 DNA topoisomerase, type IA, domain 2 GO:0003677|GO:0003916|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 SMART SM00493 3 103 9.5E-26 T 21-04-2016 IPR006171 Toprim domain SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Hamap MF_00952 DNA topoisomerase 1 [topA]. 3 670 48.714 T 21-04-2016 IPR028612 DNA topoisomerase I, type IA GO:0003677|GO:0003916|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Gene3D G3DSA:3.40.50.140 1 132 3.1E-44 T 21-04-2016 IPR006171 Toprim domain SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 SUPERFAMILY SSF56712 518 602 5.36E-177 T 21-04-2016 IPR023405 DNA topoisomerase, type IA, core domain SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 SUPERFAMILY SSF56712 3 486 5.36E-177 T 21-04-2016 IPR023405 DNA topoisomerase, type IA, core domain SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Pfam PF13368 Topoisomerase C-terminal repeat 662 709 2.6E-12 T 21-04-2016 IPR025589 Topoisomerase C-terminal repeat SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Pfam PF13368 Topoisomerase C-terminal repeat 725 767 2.3E-8 T 21-04-2016 IPR025589 Topoisomerase C-terminal repeat SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Pfam PF13368 Topoisomerase C-terminal repeat 599 658 1.2E-14 T 21-04-2016 IPR025589 Topoisomerase C-terminal repeat SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PANTHER PTHR11390:SF27 1 488 8.9E-265 T 21-04-2016 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 PANTHER PTHR11390:SF27 518 615 8.9E-265 T 21-04-2016 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 TIGRFAM TIGR01051 topA_bact: DNA topoisomerase I 5 489 7.4E-188 T 21-04-2016 IPR005733 DNA topoisomerase I, bacterial-type GO:0003677|GO:0003917|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Gene3D G3DSA:1.10.460.10 441 486 3.5E-54 T 21-04-2016 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Gene3D G3DSA:1.10.460.10 133 186 3.5E-54 T 21-04-2016 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Gene3D G3DSA:1.10.460.10 518 582 3.5E-54 T 21-04-2016 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 ProSitePatterns PS00396 Prokaryotic DNA topoisomerase I active site. 276 290 - T 21-04-2016 IPR023406 DNA topoisomerase, type IA, active site GO:0003917 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Gene3D G3DSA:2.70.20.10 307 440 6.0E-29 T 21-04-2016 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Gene3D G3DSA:2.70.20.10 204 303 1.3E-25 T 21-04-2016 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Pfam PF01751 Toprim domain 5 113 1.2E-26 T 21-04-2016 IPR006171 Toprim domain SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Pfam PF01131 DNA topoisomerase 127 489 1.1E-109 T 21-04-2016 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 SPH21_RS15805 831275d130f41fab180fc591e73bb325 787 Pfam PF01131 DNA topoisomerase 510 569 1.5E-7 T 21-04-2016 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 Gene3D G3DSA:3.40.50.300 203 384 1.2E-36 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 PIRSF PIRSF006809 7 397 2.7E-137 T 21-04-2016 IPR016496 GTPase HflX GO:0005525 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 PANTHER PTHR10229 4 393 1.2E-159 T 21-04-2016 IPR016496 GTPase HflX GO:0005525 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 Hamap MF_00900 GTPase HflX [hflX]. 35 395 44.944 T 21-04-2016 IPR016496 GTPase HflX GO:0005525 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 272 290 8.4E-9 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 206 226 8.4E-9 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 TIGRFAM TIGR03156 GTP_HflX: GTP-binding protein HflX 15 382 1.3E-136 T 21-04-2016 IPR016496 GTPase HflX GO:0005525 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 SUPERFAMILY SSF52540 204 387 4.22E-40 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 Pfam PF16360 GTP-binding GTPase Middle Region 122 200 5.0E-33 T 21-04-2016 IPR032305 GTP-binding protein, middle domain SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 Pfam PF01926 50S ribosome-binding GTPase 205 323 2.3E-21 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 Pfam PF13167 GTP-binding GTPase N-terminal 33 120 7.9E-35 T 21-04-2016 IPR025121 GTPase HflX, N-terminal SPH21_RS05695 796abd1280a88265b7b82f9eb2cb74d7 400 PANTHER PTHR10229:SF0 4 393 1.2E-159 T 21-04-2016 SPH21_RS04115 34bff1428dee753ec872fc6b812d370f 331 Pfam PF01156 Inosine-uridine preferring nucleoside hydrolase 30 277 3.4E-23 T 21-04-2016 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SPH21_RS04115 34bff1428dee753ec872fc6b812d370f 331 PANTHER PTHR12304:SF24 1 326 1.3E-56 T 21-04-2016 SPH21_RS04115 34bff1428dee753ec872fc6b812d370f 331 PANTHER PTHR12304 1 326 1.3E-56 T 21-04-2016 IPR023186 Inosine/uridine-preferring nucleoside hydrolase SPH21_RS04115 34bff1428dee753ec872fc6b812d370f 331 Gene3D G3DSA:3.90.245.10 30 274 5.0E-25 T 21-04-2016 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SPH21_RS04115 34bff1428dee753ec872fc6b812d370f 331 SUPERFAMILY SSF53590 30 293 7.85E-27 T 21-04-2016 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 PANTHER PTHR24221 9 572 6.7E-129 T 21-04-2016 SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 SUPERFAMILY SSF52540 326 565 1.42E-66 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 SMART SM00382 356 556 2.2E-7 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 Pfam PF00005 ABC transporter 347 495 1.7E-31 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 ProSitePatterns PS00211 ABC transporters family signature. 467 481 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 Gene3D G3DSA:1.20.1560.10 9 316 2.1E-55 T 21-04-2016 SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 SUPERFAMILY SSF90123 8 316 9.16E-59 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 Pfam PF00664 ABC transporter transmembrane region 20 288 9.3E-40 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS18725 a4cd39dc523cdc0de00a45fb977d6b15 573 Gene3D G3DSA:3.40.50.300 334 568 4.7E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14720 ca99a02b1995d59d96c86f44e7818ee8 515 Pfam PF12771 Starch-binding associating with outer membrane 1 511 5.6E-66 T 21-04-2016 SPH21_RS14720 ca99a02b1995d59d96c86f44e7818ee8 515 SUPERFAMILY SSF48452 20 512 7.33E-113 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14720 ca99a02b1995d59d96c86f44e7818ee8 515 PANTHER PTHR35148 1 515 1.6E-63 T 21-04-2016 SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 SMART SM01359 972 1114 9.7E-33 T 21-04-2016 IPR011625 Alpha-2-macroglobulin, N-terminal 2 SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 Pfam PF10569 Alpha-macro-globulin thiol-ester bond-forming region 1380 1403 1.2E-7 T 21-04-2016 IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 PANTHER PTHR40094:SF1 28 1834 6.9E-124 T 21-04-2016 SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 Pfam PF11974 Alpha-2-macroglobulin MG1 domain 506 600 7.6E-18 T 21-04-2016 IPR021868 Alpha-2-macroglobulin MG1 domain SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 PANTHER PTHR40094 28 1834 6.9E-124 T 21-04-2016 SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 SUPERFAMILY SSF48239 1379 1629 7.46E-41 T 21-04-2016 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 Pfam PF07703 Alpha-2-macroglobulin family N-terminal region 975 1114 8.0E-16 T 21-04-2016 IPR011625 Alpha-2-macroglobulin, N-terminal 2 SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 SMART SM01360 1177 1268 1.1E-18 T 21-04-2016 IPR001599 Alpha-2-macroglobulin GO:0004866 SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 Gene3D G3DSA:1.50.10.20 1379 1629 6.6E-25 T 21-04-2016 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 Pfam PF00207 Alpha-2-macroglobulin family 1187 1267 1.7E-9 T 21-04-2016 IPR001599 Alpha-2-macroglobulin GO:0004866 SPH21_RS20475 508f57a99d7d01b7847d53331bda1e57 1834 Pfam PF01835 MG2 domain 607 695 2.9E-15 T 21-04-2016 IPR002890 Alpha-2-macroglobulin, N-terminal GO:0004866 SPH21_RS24355 2dd8190ac562eb24b7d754b4c6e98595 95 PANTHER PTHR33678 14 83 1.6E-16 T 21-04-2016 SPH21_RS24355 2dd8190ac562eb24b7d754b4c6e98595 95 Pfam PF03050 Transposase IS66 family 14 40 5.0E-7 T 21-04-2016 IPR004291 Transposase, IS66 SPH21_RS24355 2dd8190ac562eb24b7d754b4c6e98595 95 PANTHER PTHR33678:SF1 14 83 1.6E-16 T 21-04-2016 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 Pfam PF01134 Glucose inhibited division protein A 6 394 3.7E-157 T 21-04-2016 IPR002218 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related GO:0008033|GO:0050660 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 Hamap MF_00129 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG [mnmG]. 3 620 39.672 T 21-04-2016 IPR004416 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG GO:0002098 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 ProSitePatterns PS01280 Glucose inhibited division protein A family signature 1. 270 284 - T 21-04-2016 IPR020595 MnmG-related, conserved site SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 TIGRFAM TIGR00136 gidA: tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 5 619 1.2E-248 T 21-04-2016 IPR004416 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG GO:0002098 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 Gene3D G3DSA:3.50.50.60 4 171 6.6E-34 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 SMART SM01228 545 616 3.9E-36 T 21-04-2016 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 SUPERFAMILY SSF51905 4 66 9.89E-44 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 SUPERFAMILY SSF51905 97 256 9.89E-44 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 ProSitePatterns PS01281 Glucose inhibited division protein A family signature 2. 365 388 - T 21-04-2016 IPR020595 MnmG-related, conserved site SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 Pfam PF13932 GidA associated domain 398 615 2.3E-66 T 21-04-2016 IPR026904 GidA associated domain 3 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 PANTHER PTHR11806 4 618 0.0 T 21-04-2016 SPH21_RS06400 da704374975bfcb577da7164f0a0fa09 620 PANTHER PTHR11806:SF0 4 618 0.0 T 21-04-2016 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 42 60 4.6E-7 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 28 42 4.6E-7 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 PANTHER PTHR30363 4 257 2.4E-78 T 21-04-2016 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 ProSitePatterns PS00894 DeoR-type HTH domain signature. 10 44 - T 21-04-2016 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 Pfam PF08220 DeoR-like helix-turn-helix domain 10 62 7.0E-16 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 SUPERFAMILY SSF100950 78 238 8.58E-27 T 21-04-2016 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 Gene3D G3DSA:3.40.50.1360 81 219 4.1E-10 T 21-04-2016 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 SUPERFAMILY SSF46785 7 78 3.91E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 SMART SM00420 10 62 3.2E-20 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 Gene3D G3DSA:1.10.10.10 3 63 1.6E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 PANTHER PTHR30363:SF1 4 257 2.4E-78 T 21-04-2016 SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 Pfam PF00455 DeoR C terminal sensor domain 79 237 2.2E-48 T 21-04-2016 IPR014036 DeoR C-terminal sensor domain SPH21_RS12965 e9800dac4a55968d1fa01a46c6a15357 257 SMART SM01134 77 238 2.8E-64 T 21-04-2016 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Gene3D G3DSA:1.25.40.10 147 254 3.1E-26 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Gene3D G3DSA:1.25.40.10 324 440 1.6E-27 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Gene3D G3DSA:1.25.40.10 255 323 8.0E-23 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SUPERFAMILY SSF48439 56 303 1.07E-37 T 21-04-2016 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Gene3D G3DSA:1.25.40.10 42 146 4.9E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Pfam PF13432 Tetratricopeptide repeat 345 408 2.8E-9 T 21-04-2016 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Pfam PF13432 Tetratricopeptide repeat 42 94 0.0062 T 21-04-2016 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 PANTHER PTHR23083 17 467 7.9E-77 T 21-04-2016 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SUPERFAMILY SSF48439 219 441 5.23E-38 T 21-04-2016 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Pfam PF13181 Tetratricopeptide repeat 272 304 8.2E-9 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Pfam PF13181 Tetratricopeptide repeat 238 268 0.0011 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Pfam PF12895 Anaphase-promoting complex, cyclosome, subunit 3 117 192 2.1E-8 T 21-04-2016 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 306 339 0.059 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 102 135 1.4 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 408 441 18.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 136 169 0.048 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 204 237 3.4E-6 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 272 305 1.3E-7 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 340 373 9.7E-4 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 170 203 250.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 68 101 31.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 238 271 0.0041 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 SMART SM00028 374 407 120.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06580 3524428d5dc6a82fd9cff7ce3a872f00 467 Pfam PF00515 Tetratricopeptide repeat 205 237 6.3E-8 T 21-04-2016 IPR001440 Tetratricopeptide repeat 1 GO:0005515 SPH21_RS09745 db55f3f92cf5b15236837fb9735f8dba 142 SUPERFAMILY SSF54427 25 140 4.05E-9 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS09745 db55f3f92cf5b15236837fb9735f8dba 142 Gene3D G3DSA:3.10.450.50 24 135 1.5E-14 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS09745 db55f3f92cf5b15236837fb9735f8dba 142 Pfam PF12893 Putative lumazine-binding 32 134 4.5E-10 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PANTHER PTHR32063:SF24 1057 1105 0.0 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PANTHER PTHR32063:SF24 2 1031 0.0 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 TIGRFAM TIGR00914 2A0601: heavy metal efflux pump, CzcA family 1 1035 0.0 T 21-04-2016 IPR004763 Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA GO:0006812|GO:0008324|GO:0016021 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF82693 42 133 1.92E-21 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF82714 728 814 7.19E-20 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Gene3D G3DSA:3.30.70.1430 42 141 3.4E-24 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Pfam PF02321 Outer membrane efflux protein 1076 1250 1.7E-12 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Pfam PF02321 Outer membrane efflux protein 1275 1457 4.9E-19 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Gene3D G3DSA:1.20.1600.10 1071 1457 7.2E-77 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF82693 152 188 1.65E-17 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF82866 811 1040 9.29E-53 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF82866 301 506 6.8E-32 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Gene3D G3DSA:3.30.2090.10 189 272 9.6E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Gene3D G3DSA:3.30.2090.10 728 813 1.0E-20 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF56954 1045 1457 5.62E-52 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF82714 189 272 2.09E-15 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Pfam PF00873 AcrB/AcrD/AcrF family 5 1034 6.1E-291 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 SUPERFAMILY SSF82693 279 335 1.65E-17 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PRINTS PR00702 Acriflavin resistance protein family signature 368 389 5.6E-22 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PRINTS PR00702 Acriflavin resistance protein family signature 455 478 5.6E-22 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PRINTS PR00702 Acriflavin resistance protein family signature 556 573 5.6E-22 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PRINTS PR00702 Acriflavin resistance protein family signature 40 58 5.6E-22 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PRINTS PR00702 Acriflavin resistance protein family signature 341 364 5.6E-22 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PRINTS PR00702 Acriflavin resistance protein family signature 480 503 5.6E-22 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PRINTS PR00702 Acriflavin resistance protein family signature 12 36 5.6E-22 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Gene3D G3DSA:1.10.3850.10 286 509 1.8E-48 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 Gene3D G3DSA:1.10.3850.10 819 1036 9.0E-57 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PANTHER PTHR32063 1057 1105 0.0 T 21-04-2016 SPH21_RS01100 c3a2c91ef0f9930aa147c4d1bb892dad 1460 PANTHER PTHR32063 2 1031 0.0 T 21-04-2016 SPH21_RS25120 f266640a03e7bbe14274f01707285ae9 162 Pfam PF12867 DinB superfamily 28 151 1.1E-7 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS25120 f266640a03e7bbe14274f01707285ae9 162 SUPERFAMILY SSF109854 28 158 6.23E-11 T 21-04-2016 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 Gene3D G3DSA:2.40.160.20 15 230 2.8E-9 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 PANTHER PTHR30128 323 434 7.1E-40 T 21-04-2016 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 Gene3D G3DSA:3.30.1330.60 312 433 1.7E-37 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 PRINTS PR01021 OMPA domain signature 363 378 1.4E-13 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 PRINTS PR01021 OMPA domain signature 378 394 1.4E-13 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 PRINTS PR01021 OMPA domain signature 334 356 1.4E-13 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 Pfam PF00691 OmpA family 334 427 2.2E-22 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 Pfam PF13505 Outer membrane protein beta-barrel domain 13 199 8.9E-10 T 21-04-2016 IPR027385 Outer membrane protein beta-barrel SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 378 395 2.5E-6 T 21-04-2016 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 416 434 2.5E-6 T 21-04-2016 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 396 415 2.5E-6 T 21-04-2016 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 SUPERFAMILY SSF103647 275 304 2.35E-5 T 21-04-2016 IPR028974 TSP type-3 repeat GO:0005509 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 SUPERFAMILY SSF103088 309 433 1.7E-34 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 SUPERFAMILY SSF56925 44 213 4.45E-9 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS11945 c708197e57d2c57b8fe4734a8d1aeef4 434 Gene3D G3DSA:4.10.1080.10 268 304 3.2E-4 T 21-04-2016 IPR028974 TSP type-3 repeat GO:0005509 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 PANTHER PTHR26402:SF50 6 227 2.2E-89 T 21-04-2016 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 PANTHER PTHR26402 6 227 2.2E-89 T 21-04-2016 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 SMART SM00448 6 119 1.4E-42 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 Pfam PF00072 Response regulator receiver domain 8 120 1.7E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 Pfam PF00486 Transcriptional regulatory protein, C terminal 156 226 4.9E-23 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 Gene3D G3DSA:1.10.10.10 134 227 1.1E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 Gene3D G3DSA:3.40.50.2300 2 131 2.2E-44 T 21-04-2016 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 SMART SM00862 155 226 7.4E-23 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 SUPERFAMILY SSF52172 3 131 1.17E-42 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS15465 d6b402dd13f1f20fea3e1864c37d9dc4 228 SUPERFAMILY SSF46894 134 227 9.64E-27 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 Pfam PF08331 Domain of unknown function (DUF1730) 61 134 6.6E-21 T 21-04-2016 IPR013542 Domain of unknown function DUF1730 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 Pfam PF13484 4Fe-4S double cluster binding domain 188 251 8.5E-20 T 21-04-2016 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 PANTHER PTHR30002:SF4 1 305 1.1E-131 T 21-04-2016 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 TIGRFAM TIGR00276 TIGR00276: epoxyqueuosine reductase 12 305 2.2E-104 T 21-04-2016 IPR004453 Epoxyqueuosine reductase QueG GO:0008033|GO:0008616|GO:0016491 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 188 199 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 SUPERFAMILY SSF46548 133 251 5.23E-15 T 21-04-2016 IPR009051 Alpha-helical ferredoxin GO:0051536 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 Gene3D G3DSA:3.30.70.20 185 254 1.6E-7 T 21-04-2016 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 PANTHER PTHR30002 1 305 1.1E-131 T 21-04-2016 SPH21_RS17590 d8b1ecbfb60c99f8259074199433215e 311 Hamap MF_00916 Epoxyqueuosine reductase [queG]. 5 310 46.17 T 21-04-2016 IPR004453 Epoxyqueuosine reductase QueG GO:0008033|GO:0008616|GO:0016491 MetaCyc: PWY-6700|UniPathway: UPA00392 SPH21_RS14485 492b6d67445dc24de0db132da1baade9 134 PANTHER PTHR37297:SF1 2 134 1.7E-35 T 21-04-2016 SPH21_RS14485 492b6d67445dc24de0db132da1baade9 134 Pfam PF07972 NrdI Flavodoxin like 5 115 1.4E-25 T 21-04-2016 IPR004465 Ribonucleotide reductase Class Ib, NrdI SPH21_RS14485 492b6d67445dc24de0db132da1baade9 134 Gene3D G3DSA:3.40.50.360 5 124 1.3E-32 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS14485 492b6d67445dc24de0db132da1baade9 134 PANTHER PTHR37297 2 134 1.7E-35 T 21-04-2016 SPH21_RS14485 492b6d67445dc24de0db132da1baade9 134 PIRSF PIRSF005087 1 130 1.3E-31 T 21-04-2016 IPR004465 Ribonucleotide reductase Class Ib, NrdI SPH21_RS14485 492b6d67445dc24de0db132da1baade9 134 SUPERFAMILY SSF52218 2 122 1.22E-15 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS14485 492b6d67445dc24de0db132da1baade9 134 TIGRFAM TIGR00333 nrdI: nrdI protein 5 119 3.0E-30 T 21-04-2016 IPR004465 Ribonucleotide reductase Class Ib, NrdI SPH21_RS14040 e2483541ddc53bcf64fc03d5846b1a2d 555 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 68 227 1.4E-14 T 21-04-2016 SPH21_RS14040 e2483541ddc53bcf64fc03d5846b1a2d 555 PANTHER PTHR33908:SF3 1 441 2.8E-29 T 21-04-2016 SPH21_RS14040 e2483541ddc53bcf64fc03d5846b1a2d 555 PANTHER PTHR33908 1 441 2.8E-29 T 21-04-2016 SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 Gene3D G3DSA:3.30.1360.40 240 309 2.1E-14 T 21-04-2016 IPR024946 Arginine repressor C-terminal-like domain SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 SUPERFAMILY SSF56719 15 481 9.42E-106 T 21-04-2016 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 45 463 6.0E-103 T 21-04-2016 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 SMART SM00434 24 460 1.1E-68 T 21-04-2016 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 PANTHER PTHR10169:SF48 31 329 7.7E-132 T 21-04-2016 SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 Gene3D G3DSA:3.90.199.10 44 239 2.1E-59 T 21-04-2016 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 Gene3D G3DSA:3.90.199.10 320 372 2.1E-59 T 21-04-2016 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 SPH21_RS08180 3d7c5f71aec54d15f84266dba8ecad84 902 PANTHER PTHR10169 31 329 7.7E-132 T 21-04-2016 SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 Gene3D G3DSA:1.20.1250.20 25 206 1.5E-9 T 21-04-2016 SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 SUPERFAMILY SSF103473 23 438 3.79E-35 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 Pfam PF07690 Major Facilitator Superfamily 30 347 6.1E-15 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 PANTHER PTHR23526:SF2 1 392 1.4E-71 T 21-04-2016 SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 PANTHER PTHR23526:SF2 409 484 1.4E-71 T 21-04-2016 SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 PANTHER PTHR23526 1 392 1.4E-71 T 21-04-2016 SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 PANTHER PTHR23526 409 484 1.4E-71 T 21-04-2016 SPH21_RS18540 51ab38d03bb9cac33a66a7aa12b55c2b 489 Gene3D G3DSA:1.20.1250.20 229 442 1.5E-16 T 21-04-2016 SPH21_RS26070 d34d72c2df83b4c34a339d9864dd0258 363 ProSitePatterns PS00194 Thioredoxin family active site. 252 270 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS26070 d34d72c2df83b4c34a339d9864dd0258 363 Gene3D G3DSA:3.40.30.10 220 359 5.5E-48 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26070 d34d72c2df83b4c34a339d9864dd0258 363 SUPERFAMILY SSF52833 221 347 6.43E-32 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26070 d34d72c2df83b4c34a339d9864dd0258 363 PANTHER PTHR13871 238 348 5.3E-23 T 21-04-2016 SPH21_RS26070 d34d72c2df83b4c34a339d9864dd0258 363 Pfam PF00578 AhpC/TSA family 225 343 2.6E-23 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS06460 20b36fbd71c27367ffef00e92cca4fe9 164 Gene3D G3DSA:3.40.30.10 28 151 1.2E-23 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS06460 20b36fbd71c27367ffef00e92cca4fe9 164 Pfam PF13899 Thioredoxin-like 34 120 1.3E-13 T 21-04-2016 SPH21_RS06460 20b36fbd71c27367ffef00e92cca4fe9 164 SUPERFAMILY SSF52833 33 150 2.31E-19 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS13020 5ddc1bf1625a43d56e1ca57d5d1f3422 126 PANTHER PTHR33204 3 120 3.0E-27 T 21-04-2016 SPH21_RS13020 5ddc1bf1625a43d56e1ca57d5d1f3422 126 SUPERFAMILY SSF46785 18 110 9.85E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13020 5ddc1bf1625a43d56e1ca57d5d1f3422 126 Gene3D G3DSA:1.10.10.10 6 121 9.5E-34 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13020 5ddc1bf1625a43d56e1ca57d5d1f3422 126 Pfam PF01638 HxlR-like helix-turn-helix 24 111 1.8E-26 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 SUPERFAMILY SSF53067 4 246 9.72E-42 T 21-04-2016 SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 4 241 2.7E-36 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 PIRSF PIRSF000538 2 477 9.6E-69 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 254 428 1.9E-14 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 PANTHER PTHR10196 1 469 2.0E-80 T 21-04-2016 SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 SUPERFAMILY SSF53067 247 468 1.94E-25 T 21-04-2016 SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 Gene3D G3DSA:3.30.420.40 245 469 7.1E-22 T 21-04-2016 SPH21_RS02145 02ec159e5d1f3a59865b00a228370e0a 479 Gene3D G3DSA:3.30.420.40 1 240 2.4E-42 T 21-04-2016 SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 7 53 2.5E-5 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 Gene3D G3DSA:3.10.20.30 3 75 4.6E-23 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 PANTHER PTHR11908 1 136 1.5E-24 T 21-04-2016 SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 Gene3D G3DSA:1.10.150.120 76 151 9.4E-27 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 PANTHER PTHR11908:SF66 1 136 1.5E-24 T 21-04-2016 SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 SUPERFAMILY SSF47741 81 150 1.09E-24 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 SUPERFAMILY SSF54292 3 79 4.19E-21 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS05840 a1dc12744cba14ca15e0039a6bb0d0b1 157 Pfam PF01799 [2Fe-2S] binding domain 74 146 9.2E-23 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS02445 60cc6784d7678bcdec159df42b812f5b 975 Gene3D G3DSA:3.30.379.10 38 160 4.5E-11 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS02445 60cc6784d7678bcdec159df42b812f5b 975 PANTHER PTHR37842 79 964 1.9E-239 T 21-04-2016 SPH21_RS02445 60cc6784d7678bcdec159df42b812f5b 975 PANTHER PTHR37842:SF1 79 964 1.9E-239 T 21-04-2016 SPH21_RS02445 60cc6784d7678bcdec159df42b812f5b 975 Pfam PF15979 Glycosyl hydrolase family 115 178 521 3.7E-130 T 21-04-2016 IPR031924 Glycosyl hydrolase family 115 SPH21_RS06380 b9d95c992af472def496599948e00090 331 Hamap MF_00568 Quinolinate synthase A [nadA]. 22 325 46.108 T 21-04-2016 IPR023066 Quinolinate synthase A, type 2 GO:0016765 MetaCyc: PWY-5316|MetaCyc: PWY-7342|UniPathway: UPA00253 SPH21_RS06380 b9d95c992af472def496599948e00090 331 Pfam PF02445 Quinolinate synthetase A protein 26 324 1.2E-120 T 21-04-2016 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342|UniPathway: UPA00253 SPH21_RS06380 b9d95c992af472def496599948e00090 331 PANTHER PTHR30573 14 328 1.2E-155 T 21-04-2016 SPH21_RS06380 b9d95c992af472def496599948e00090 331 TIGRFAM TIGR00550 nadA: quinolinate synthetase complex, A subunit 23 326 6.2E-123 T 21-04-2016 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342|UniPathway: UPA00253 SPH21_RS06380 b9d95c992af472def496599948e00090 331 SUPERFAMILY SSF142754 23 325 5.49E-118 T 21-04-2016 SPH21_RS07575 f74ca8092a2fc89a8381eab5caceab0e 209 Gene3D G3DSA:2.60.40.10 119 206 4.1E-6 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS07575 f74ca8092a2fc89a8381eab5caceab0e 209 SUPERFAMILY SSF49265 115 205 2.27E-7 T 21-04-2016 IPR003961 Fibronectin type III GO:0005515 SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 Gene3D G3DSA:2.60.120.260 322 464 1.5E-36 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 PANTHER PTHR22925:SF37 27 349 2.8E-88 T 21-04-2016 SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 Gene3D G3DSA:2.115.10.20 17 308 6.6E-70 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 Pfam PF04616 Glycosyl hydrolases family 43 28 307 6.8E-48 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 SUPERFAMILY SSF49785 324 464 1.51E-19 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 SMART SM00606 324 465 2.4E-14 T 21-04-2016 IPR006584 Cellulose binding, type IV GO:0030246 SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 PANTHER PTHR22925 27 349 2.8E-88 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 Pfam PF03422 Carbohydrate binding module (family 6) 332 464 2.2E-22 T 21-04-2016 IPR005084 Carbohydrate binding module family 6 GO:0030246 SPH21_RS20645 2f7df1cfe1f365f96fc3094214c2ca5f 465 SUPERFAMILY SSF75005 14 308 2.86E-63 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS09490 b78fff7934ad274ee0a63b9bcd40d109 586 Gene3D G3DSA:1.25.40.10 203 331 7.0E-38 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09490 b78fff7934ad274ee0a63b9bcd40d109 586 Gene3D G3DSA:1.25.40.10 421 507 7.0E-38 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09490 b78fff7934ad274ee0a63b9bcd40d109 586 Pfam PF07980 SusD family 291 585 1.2E-54 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09490 b78fff7934ad274ee0a63b9bcd40d109 586 Pfam PF14322 Starch-binding associating with outer membrane 22 223 1.8E-25 T 21-04-2016 SPH21_RS09490 b78fff7934ad274ee0a63b9bcd40d109 586 SUPERFAMILY SSF48452 18 585 1.4E-124 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 SMART SM00342 183 266 1.2E-27 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 Pfam PF12833 Helix-turn-helix domain 189 267 5.6E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 SUPERFAMILY SSF46689 169 218 8.24E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 250 266 3.8E-8 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 235 250 3.8E-8 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 SUPERFAMILY SSF46689 220 267 5.82E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 Gene3D G3DSA:1.10.10.60 220 267 4.8E-18 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 PANTHER PTHR11019 36 268 1.3E-25 T 21-04-2016 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 Gene3D G3DSA:2.60.120.10 19 97 1.3E-10 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 Gene3D G3DSA:1.10.10.60 169 219 4.8E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 SUPERFAMILY SSF51182 27 96 8.5E-8 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS16085 3764374454201a8e1fc3153d673e04c7 268 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 220 262 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 PANTHER PTHR30069:SF1 22 638 1.4E-29 T 21-04-2016 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 Gene3D G3DSA:2.60.40.1120 25 97 3.9E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 Gene3D G3DSA:2.170.130.10 106 218 1.4E-9 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 Gene3D G3DSA:2.40.170.20 224 739 6.0E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 SUPERFAMILY SSF49464 24 107 6.08E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 Pfam PF13715 CarboxypepD_reg-like domain 26 109 7.9E-14 T 21-04-2016 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 PANTHER PTHR30069 22 638 1.4E-29 T 21-04-2016 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 Pfam PF07715 TonB-dependent Receptor Plug Domain 140 218 8.9E-11 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 SUPERFAMILY SSF56935 489 748 1.14E-70 T 21-04-2016 SPH21_RS18515 a0c8d01cf72089e7f166578f432dcbde 774 SUPERFAMILY SSF56935 105 460 1.14E-70 T 21-04-2016 SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 Pfam PF00753 Metallo-beta-lactamase superfamily 34 245 4.0E-28 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 PANTHER PTHR11935:SF107 211 266 4.9E-85 T 21-04-2016 SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 PANTHER PTHR11935:SF107 2 194 4.9E-85 T 21-04-2016 SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 SUPERFAMILY SSF56281 22 252 2.23E-43 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 PANTHER PTHR11935 211 266 4.9E-85 T 21-04-2016 SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 PANTHER PTHR11935 2 194 4.9E-85 T 21-04-2016 SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 Gene3D G3DSA:3.60.15.10 14 249 4.0E-34 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS10750 a743aeb52b80cefa266c883e8087400a 278 SMART SM00849 35 245 1.5E-28 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS12715 3dc5b8436cf535e1133a2b75eae3dd57 253 PANTHER PTHR30060:SF1 9 252 1.7E-88 T 21-04-2016 SPH21_RS12715 3dc5b8436cf535e1133a2b75eae3dd57 253 Pfam PF03741 Integral membrane protein TerC family 18 211 7.0E-48 T 21-04-2016 IPR005496 Integral membrane protein TerC GO:0016021 SPH21_RS12715 3dc5b8436cf535e1133a2b75eae3dd57 253 PANTHER PTHR30060 9 252 1.7E-88 T 21-04-2016 SPH21_RS13225 57fa98809b4a40b1901445340e9a88d2 451 PANTHER PTHR30386:SF8 37 448 9.8E-39 T 21-04-2016 SPH21_RS13225 57fa98809b4a40b1901445340e9a88d2 451 Pfam PF13533 Biotin-lipoyl like 73 107 2.2E-8 T 21-04-2016 SPH21_RS13225 57fa98809b4a40b1901445340e9a88d2 451 Gene3D G3DSA:2.40.50.100 285 322 2.3E-11 T 21-04-2016 SPH21_RS13225 57fa98809b4a40b1901445340e9a88d2 451 Gene3D G3DSA:2.40.50.100 68 103 2.3E-11 T 21-04-2016 SPH21_RS13225 57fa98809b4a40b1901445340e9a88d2 451 Pfam PF13437 HlyD family secretion protein 292 363 7.7E-5 T 21-04-2016 SPH21_RS13225 57fa98809b4a40b1901445340e9a88d2 451 PANTHER PTHR30386 37 448 9.8E-39 T 21-04-2016 SPH21_RS05910 602d7dc4275c4e77ef1c39fe0f1c0e90 195 PANTHER PTHR24188 50 149 1.9E-26 T 21-04-2016 SPH21_RS05910 602d7dc4275c4e77ef1c39fe0f1c0e90 195 SUPERFAMILY SSF48403 50 151 2.64E-28 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS05910 602d7dc4275c4e77ef1c39fe0f1c0e90 195 Pfam PF12796 Ankyrin repeats (3 copies) 50 143 2.9E-16 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS05910 602d7dc4275c4e77ef1c39fe0f1c0e90 195 SMART SM00248 79 108 0.0018 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS05910 602d7dc4275c4e77ef1c39fe0f1c0e90 195 SMART SM00248 112 141 0.0015 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS05910 602d7dc4275c4e77ef1c39fe0f1c0e90 195 Gene3D G3DSA:1.25.40.20 50 154 5.5E-27 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 Gene3D G3DSA:3.40.630.10 31 88 1.1E-60 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 Gene3D G3DSA:3.40.630.10 286 532 1.1E-60 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 Pfam PF02225 PA domain 139 220 3.3E-6 T 21-04-2016 IPR003137 PA domain SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 Gene3D G3DSA:3.50.30.30 136 216 4.2E-4 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 SUPERFAMILY SSF52025 137 217 1.57E-5 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 SUPERFAMILY SSF53187 285 525 9.53E-62 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 SUPERFAMILY SSF53187 33 82 9.53E-62 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 Pfam PF04389 Peptidase family M28 301 504 2.8E-47 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 PANTHER PTHR12147:SF20 240 475 4.5E-139 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 PANTHER PTHR12147:SF20 491 543 4.5E-139 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 PANTHER PTHR12147:SF20 35 208 4.5E-139 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 PANTHER PTHR12147 240 475 4.5E-139 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 PANTHER PTHR12147 491 543 4.5E-139 T 21-04-2016 SPH21_RS08165 35b4d7552e590bdbe8e5ea59964cd50f 547 PANTHER PTHR12147 35 208 4.5E-139 T 21-04-2016 SPH21_RS01455 33bbdcbdbdff1d811cf7a5b44b52ddfe 298 PIRSF PIRSF006232 4 285 3.2E-50 T 21-04-2016 IPR012093 Pirin SPH21_RS01455 33bbdcbdbdff1d811cf7a5b44b52ddfe 298 PANTHER PTHR13903 38 294 2.8E-56 T 21-04-2016 IPR012093 Pirin SPH21_RS01455 33bbdcbdbdff1d811cf7a5b44b52ddfe 298 SUPERFAMILY SSF51182 8 284 1.05E-50 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS01455 33bbdcbdbdff1d811cf7a5b44b52ddfe 298 Pfam PF05726 Pirin C-terminal cupin domain 166 278 1.0E-21 T 21-04-2016 IPR008778 Pirin, C-terminal domain SPH21_RS01455 33bbdcbdbdff1d811cf7a5b44b52ddfe 298 Gene3D G3DSA:2.60.120.10 2 252 1.6E-49 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS01455 33bbdcbdbdff1d811cf7a5b44b52ddfe 298 Pfam PF02678 Pirin 58 112 1.3E-10 T 21-04-2016 IPR003829 Pirin, N-terminal domain SPH21_RS16530 0913d79b72c3abd4e7309b03c16e44d9 248 PANTHER PTHR41260:SF1 2 245 6.9E-97 T 21-04-2016 SPH21_RS16530 0913d79b72c3abd4e7309b03c16e44d9 248 PANTHER PTHR41260 2 245 6.9E-97 T 21-04-2016 SPH21_RS16530 0913d79b72c3abd4e7309b03c16e44d9 248 Pfam PF12787 EcsC protein family 8 237 1.1E-74 T 21-04-2016 IPR024787 EcsC protein SPH21_RS16530 0913d79b72c3abd4e7309b03c16e44d9 248 ProDom PD038378 ECSC YDBA CC1715 BH1193 ECSC-LIKE ESCC 12 236 9.0E-57 T 21-04-2016 SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 Gene3D G3DSA:1.10.3120.10 207 386 4.3E-11 T 21-04-2016 IPR008880 Trigger factor, C-terminal GO:0006457|GO:0015031 SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 SUPERFAMILY SSF109998 262 444 1.67E-14 T 21-04-2016 IPR027304 Trigger factor/SurA domain SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 Pfam PF05697 Bacterial trigger factor protein (TF) 1 149 6.1E-33 T 21-04-2016 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 SUPERFAMILY SSF102735 1 134 4.84E-29 T 21-04-2016 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 PANTHER PTHR30560 1 446 2.5E-24 T 21-04-2016 SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 PIRSF PIRSF003095 1 445 2.1E-43 T 21-04-2016 IPR005215 Trigger factor GO:0015031 SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 TIGRFAM TIGR00115 tig: trigger factor 12 428 9.2E-61 T 21-04-2016 IPR005215 Trigger factor GO:0015031 SPH21_RS14550 e5c840caa7f436e04ee0e3e8e925b7f3 447 Gene3D G3DSA:3.30.70.1050 1 122 1.2E-28 T 21-04-2016 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 Pfam PF02261 Aspartate decarboxylase 1 114 9.3E-55 T 21-04-2016 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155|UniPathway: UPA00028 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 SUPERFAMILY SSF50692 1 115 9.32E-51 T 21-04-2016 IPR009010 Aspartate decarboxylase-like domain SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 PANTHER PTHR21012 2 116 2.2E-66 T 21-04-2016 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155|UniPathway: UPA00028 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 TIGRFAM TIGR00223 panD: aspartate 1-decarboxylase 1 114 1.9E-53 T 21-04-2016 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155|UniPathway: UPA00028 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 PIRSF PIRSF006246 1 116 1.4E-53 T 21-04-2016 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155|UniPathway: UPA00028 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 Gene3D G3DSA:2.40.40.20 1 115 1.9E-57 T 21-04-2016 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 ProDom PD009294 ASPARTATE 1-DECARBOXYLASE DECARBOXYLASE CHAIN LYASE ALPHA ALPHA- CONTAINS: PRECURSOR BETA 5 98 1.0E-35 T 21-04-2016 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155|UniPathway: UPA00028 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 Hamap MF_00446 Aspartate 1-decarboxylase [panD]. 1 116 71.93 T 21-04-2016 IPR003190 Aspartate decarboxylase GO:0004068|GO:0006523 KEGG: 00410+4.1.1.11|KEGG: 00770+4.1.1.11|MetaCyc: PWY-5155|UniPathway: UPA00028 SPH21_RS08100 afd5edc9f7965ced878624d9696b767d 116 PANTHER PTHR21012:SF0 2 116 2.2E-66 T 21-04-2016 SPH21_RS26020 bb8601d52ace3fe2c1d3e6931c01d641 448 Gene3D G3DSA:1.25.40.10 194 394 5.7E-22 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26020 bb8601d52ace3fe2c1d3e6931c01d641 448 SUPERFAMILY SSF48452 16 447 8.54E-90 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26020 bb8601d52ace3fe2c1d3e6931c01d641 448 Pfam PF14322 Starch-binding associating with outer membrane 41 211 1.1E-25 T 21-04-2016 SPH21_RS26020 bb8601d52ace3fe2c1d3e6931c01d641 448 Pfam PF07980 SusD family 306 447 5.2E-21 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS10885 0f8e764e695e8db20cf370ec424c39c5 496 Pfam PF00361 Proton-conducting membrane transporter 138 421 4.2E-63 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS10885 0f8e764e695e8db20cf370ec424c39c5 496 PANTHER PTHR22773 22 496 1.2E-111 T 21-04-2016 SPH21_RS10885 0f8e764e695e8db20cf370ec424c39c5 496 PANTHER PTHR22773:SF41 22 496 1.2E-111 T 21-04-2016 SPH21_RS10885 0f8e764e695e8db20cf370ec424c39c5 496 Hamap MF_00445 NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic [ndhB]. 17 493 15.546 T 21-04-2016 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 SPH21_RS20385 7ef2eed06082d8d5a626e851c4291c96 401 PANTHER PTHR38597 1 366 1.3E-157 T 21-04-2016 SPH21_RS20385 7ef2eed06082d8d5a626e851c4291c96 401 Pfam PF05559 Protein of unknown function (DUF763) 4 315 1.9E-127 T 21-04-2016 IPR008482 Protein of unknown function DUF763 SPH21_RS20375 15d5b66bef9e75757053d216c344187e 145 Gene3D G3DSA:3.10.450.50 26 143 1.7E-30 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS20375 15d5b66bef9e75757053d216c344187e 145 SUPERFAMILY SSF54427 26 141 4.94E-25 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS20375 15d5b66bef9e75757053d216c344187e 145 Pfam PF14534 Domain of unknown function (DUF4440) 30 135 3.2E-16 T 21-04-2016 IPR027843 Domain of unknown function DUF4440 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 Gene3D G3DSA:1.10.287.610 100 151 3.7E-23 T 21-04-2016 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 PANTHER PTHR12534 1 269 1.4E-109 T 21-04-2016 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 Gene3D G3DSA:3.40.50.10490 158 246 1.1E-67 T 21-04-2016 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 Gene3D G3DSA:3.40.50.10490 23 99 1.1E-67 T 21-04-2016 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 ProSitePatterns PS00963 Ribosomal protein S2 signature 2. 158 182 - T 21-04-2016 IPR018130 Ribosomal protein S2, conserved site GO:0003735|GO:0005840|GO:0006412 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 SUPERFAMILY SSF52313 7 236 2.49E-91 T 21-04-2016 IPR023591 Ribosomal protein S2, flavodoxin-like domain SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 TIGRFAM TIGR01011 rpsB_bact: ribosomal protein uS2 5 226 4.7E-98 T 21-04-2016 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 Hamap MF_00291_B 30S ribosomal protein S2 [rpsB]. 2 225 39.516 T 21-04-2016 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 PRINTS PR00395 Ribosomal protein S2 signature 158 175 3.6E-36 T 21-04-2016 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 PRINTS PR00395 Ribosomal protein S2 signature 37 46 3.6E-36 T 21-04-2016 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 PRINTS PR00395 Ribosomal protein S2 signature 6 24 3.6E-36 T 21-04-2016 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 PRINTS PR00395 Ribosomal protein S2 signature 87 104 3.6E-36 T 21-04-2016 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 PRINTS PR00395 Ribosomal protein S2 signature 196 210 3.6E-36 T 21-04-2016 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 PRINTS PR00395 Ribosomal protein S2 signature 175 186 3.6E-36 T 21-04-2016 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS07115 1649a583dee530bda747f18404e63cb2 274 Pfam PF00318 Ribosomal protein S2 9 224 5.2E-94 T 21-04-2016 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS03870 60dd407a2b493c9e285a3c496d81b3a2 258 PANTHER PTHR24220:SF141 9 242 1.0E-87 T 21-04-2016 SPH21_RS03870 60dd407a2b493c9e285a3c496d81b3a2 258 SMART SM00382 32 202 9.0E-7 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS03870 60dd407a2b493c9e285a3c496d81b3a2 258 PANTHER PTHR24220 9 242 1.0E-87 T 21-04-2016 SPH21_RS03870 60dd407a2b493c9e285a3c496d81b3a2 258 Pfam PF00005 ABC transporter 23 166 8.5E-27 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS03870 60dd407a2b493c9e285a3c496d81b3a2 258 Gene3D G3DSA:3.40.50.300 3 232 7.1E-67 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03870 60dd407a2b493c9e285a3c496d81b3a2 258 SUPERFAMILY SSF52540 6 229 1.28E-59 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 Pfam PF01472 PUA domain 278 345 1.1E-12 T 21-04-2016 IPR002478 PUA domain GO:0003723 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PRINTS PR00474 Glutamate 5-kinase family signature 150 177 3.5E-43 T 21-04-2016 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PRINTS PR00474 Glutamate 5-kinase family signature 210 230 3.5E-43 T 21-04-2016 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PRINTS PR00474 Glutamate 5-kinase family signature 43 57 3.5E-43 T 21-04-2016 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PRINTS PR00474 Glutamate 5-kinase family signature 78 106 3.5E-43 T 21-04-2016 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PRINTS PR00474 Glutamate 5-kinase family signature 118 139 3.5E-43 T 21-04-2016 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 SUPERFAMILY SSF53633 6 258 1.96E-60 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 TIGRFAM TIGR01027 proB: glutamate 5-kinase 6 348 2.2E-94 T 21-04-2016 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|UniPathway: UPA00098 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 SMART SM00359 278 351 4.8E-10 T 21-04-2016 IPR002478 PUA domain GO:0003723 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 Gene3D G3DSA:3.40.1160.10 6 257 1.2E-50 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 Gene3D G3DSA:2.30.130.10 276 356 2.5E-18 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 Hamap MF_00456 Glutamate 5-kinase [proB]. 6 259 31.735 T 21-04-2016 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|UniPathway: UPA00098 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PIRSF PIRSF000729 1 359 8.2E-119 T 21-04-2016 IPR011529 Glutamate 5-kinase GO:0004349|GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|UniPathway: UPA00098 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PANTHER PTHR11063 1 348 2.0E-80 T 21-04-2016 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 Pfam PF00696 Amino acid kinase family 6 236 1.2E-41 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 PANTHER PTHR11063:SF6 1 348 2.0E-80 T 21-04-2016 SPH21_RS18195 5a0620906d1d46d6889df09f75476d87 360 SUPERFAMILY SSF88697 278 357 5.03E-13 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS19305 ef39aa011d02fc6c6560d2a5fd150263 495 SMART SM00631 30 311 0.007 T 21-04-2016 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SPH21_RS19305 ef39aa011d02fc6c6560d2a5fd150263 495 Gene3D G3DSA:3.40.630.10 29 308 2.6E-30 T 21-04-2016 SPH21_RS19305 ef39aa011d02fc6c6560d2a5fd150263 495 Pfam PF00246 Zinc carboxypeptidase 65 169 3.4E-13 T 21-04-2016 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SPH21_RS19305 ef39aa011d02fc6c6560d2a5fd150263 495 SUPERFAMILY SSF53187 67 294 3.97E-33 T 21-04-2016 SPH21_RS16710 d58c46dce4a29992984d6a8bcebfc19f 329 Pfam PF02321 Outer membrane efflux protein 7 126 6.8E-14 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS16710 d58c46dce4a29992984d6a8bcebfc19f 329 Pfam PF02321 Outer membrane efflux protein 146 322 1.2E-22 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS16710 d58c46dce4a29992984d6a8bcebfc19f 329 Gene3D G3DSA:1.20.1600.10 7 322 1.7E-45 T 21-04-2016 SPH21_RS16710 d58c46dce4a29992984d6a8bcebfc19f 329 SUPERFAMILY SSF56954 7 323 5.36E-49 T 21-04-2016 SPH21_RS16710 d58c46dce4a29992984d6a8bcebfc19f 329 PANTHER PTHR30203 7 326 5.4E-42 T 21-04-2016 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 Pfam PF00361 Proton-conducting membrane transporter 125 413 1.3E-74 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 TIGRFAM TIGR01972 NDH_I_M: proton-translocating NADH-quinone oxidoreductase, chain M 5 480 6.0E-156 T 21-04-2016 IPR010227 NADH-quinone oxidoreductase, chain M/4 GO:0008137|GO:0042773|GO:0055114 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 371 397 7.3E-41 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 319 338 7.3E-41 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 231 255 7.3E-41 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 160 184 7.3E-41 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 130 149 7.3E-41 T 21-04-2016 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 PANTHER PTHR22773:SF40 1 482 2.7E-169 T 21-04-2016 SPH21_RS07915 89dc9a0622f29b67b69d4c7a1e7aa764 484 PANTHER PTHR22773 1 482 2.7E-169 T 21-04-2016 SPH21_RS19060 98d5b1ffc951b856dae4f7cedd6c47da 153 TIGRFAM TIGR02284 TIGR02284: conserved hypothetical protein 11 143 6.0E-19 T 21-04-2016 IPR011971 Conserved hypothetical protein CHP02284 SPH21_RS19060 98d5b1ffc951b856dae4f7cedd6c47da 153 Pfam PF09537 Domain of unknown function (DUF2383) 11 115 7.1E-25 T 21-04-2016 IPR019052 Domain of unknown function DUF2383 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SUPERFAMILY SSF48371 184 235 5.4E-24 T 21-04-2016 IPR016024 Armadillo-type fold GO:0005488 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SUPERFAMILY SSF48371 107 321 1.84E-5 T 21-04-2016 IPR016024 Armadillo-type fold GO:0005488 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 Gene3D G3DSA:1.25.10.10 517 712 6.1E-7 T 21-04-2016 IPR011989 Armadillo-like helical SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 Gene3D G3DSA:1.25.10.10 106 231 5.0E-8 T 21-04-2016 IPR011989 Armadillo-like helical SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 Gene3D G3DSA:1.25.10.10 283 513 1.0E-19 T 21-04-2016 IPR011989 Armadillo-like helical SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 Pfam PF13646 HEAT repeats 332 413 2.3E-9 T 21-04-2016 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SUPERFAMILY SSF48371 334 592 5.4E-24 T 21-04-2016 IPR016024 Armadillo-type fold GO:0005488 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SUPERFAMILY SSF48371 661 708 5.4E-24 T 21-04-2016 IPR016024 Armadillo-type fold GO:0005488 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 Pfam PF06439 Domain of Unknown Function (DUF1080) 941 1129 8.3E-40 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 Pfam PF06439 Domain of Unknown Function (DUF1080) 725 923 8.9E-41 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SMART SM00567 E-Z type HEAT repeats 146 175 590.0 T 21-04-2016 IPR004155 PBS lyase HEAT-like repeat SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SMART SM00567 E-Z type HEAT repeats 208 237 8.0 T 21-04-2016 IPR004155 PBS lyase HEAT-like repeat SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SMART SM00567 E-Z type HEAT repeats 374 403 450.0 T 21-04-2016 IPR004155 PBS lyase HEAT-like repeat SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SMART SM00567 E-Z type HEAT repeats 343 372 59.0 T 21-04-2016 IPR004155 PBS lyase HEAT-like repeat SPH21_RS14700 1f4736960c7b5639918273869aa3728b 1131 SMART SM00567 E-Z type HEAT repeats 566 595 9.6 T 21-04-2016 IPR004155 PBS lyase HEAT-like repeat SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 Pfam PF03099 Biotin/lipoate A/B protein ligase family 73 181 1.7E-10 T 21-04-2016 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 SUPERFAMILY SSF55681 3 228 5.39E-69 T 21-04-2016 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 TIGRFAM TIGR00214 lipB: lipoyl(octanoyl) transferase 42 226 6.7E-54 T 21-04-2016 IPR000544 Octanoyltransferase GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 ProDom PD006086 LIGASE LIPOATE-PROTEIN B TRANSFERASE ACYLTRANSFERASE LIPOYLTRANSFERASE LIPOYL-ACYL-CARRIER 2.3.1.- PROTEIN-PROTEIN- N-LIPOYLTRANSFERASE 92 145 5.0E-13 T 21-04-2016 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 PANTHER PTHR10993 5 233 7.1E-88 T 21-04-2016 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 Hamap MF_00013 Octanoyltransferase [lipB]. 4 229 35.437 T 21-04-2016 IPR000544 Octanoyltransferase GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 PIRSF PIRSF016262 1 236 2.2E-66 T 21-04-2016 IPR000544 Octanoyltransferase GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 ProSitePatterns PS01313 Lipoate-protein ligase B signature. 88 103 - T 21-04-2016 IPR020605 Octanoyltransferase, conserved site GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|UniPathway: UPA00538 SPH21_RS03465 3dd4ea4acdf7625d4e4bfc47898a9500 238 Gene3D G3DSA:3.90.1550.10 2 226 3.1E-78 T 21-04-2016 SPH21_RS12890 c535d95b1045d3dd829217c6b0358633 130 Gene3D G3DSA:3.30.370.10 4 76 1.1E-7 T 21-04-2016 IPR000468 Barstar (barnase inhibitor) SPH21_RS12890 c535d95b1045d3dd829217c6b0358633 130 Pfam PF01337 Barstar (barnase inhibitor) 7 76 4.1E-6 T 21-04-2016 IPR000468 Barstar (barnase inhibitor) SPH21_RS12890 c535d95b1045d3dd829217c6b0358633 130 SUPERFAMILY SSF52038 4 66 1.2E-7 T 21-04-2016 IPR000468 Barstar (barnase inhibitor) SPH21_RS23055 9e4c76ab71558280102aaefc34ba11e7 393 SUPERFAMILY SSF53335 90 181 9.95E-15 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS23055 9e4c76ab71558280102aaefc34ba11e7 393 Gene3D G3DSA:3.40.50.150 90 182 2.7E-9 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 Pfam PF13393 Histidyl-tRNA synthetase 99 349 5.7E-29 T 21-04-2016 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 Pfam PF13393 Histidyl-tRNA synthetase 11 69 8.2E-8 T 21-04-2016 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 TIGRFAM TIGR00442 hisS: histidine--tRNA ligase 9 448 1.2E-118 T 21-04-2016 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21|Reactome: REACT_71 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 PIRSF PIRSF001549 2 460 1.2E-129 T 21-04-2016 IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit GO:0005737 Reactome: REACT_71 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 SUPERFAMILY SSF55681 7 359 5.94E-72 T 21-04-2016 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 PANTHER PTHR11476 98 463 1.2E-171 T 21-04-2016 IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit GO:0005737 Reactome: REACT_71 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 PANTHER PTHR11476 1 75 1.2E-171 T 21-04-2016 IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit GO:0005737 Reactome: REACT_71 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 Hamap MF_00127 Histidine--tRNA ligase [hisS]. 4 458 26.711 T 21-04-2016 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21|Reactome: REACT_71 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 SUPERFAMILY SSF52954 367 458 1.66E-22 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 PANTHER PTHR11476:SF1 98 463 1.2E-171 T 21-04-2016 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 PANTHER PTHR11476:SF1 1 75 1.2E-171 T 21-04-2016 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 Gene3D G3DSA:3.30.930.10 267 362 6.4E-101 T 21-04-2016 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 Gene3D G3DSA:3.30.930.10 4 215 6.4E-101 T 21-04-2016 SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 Pfam PF03129 Anticodon binding domain 369 458 6.2E-18 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS06430 ffa5b47e3d1eb22091902fc070876566 463 Gene3D G3DSA:3.40.50.800 365 457 1.2E-25 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS20160 d480f1641b6f8515d9ceb862363f3258 192 Gene3D G3DSA:1.20.144.10 20 185 1.3E-41 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS20160 d480f1641b6f8515d9ceb862363f3258 192 Pfam PF01569 PAP2 superfamily 80 186 9.4E-24 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS20160 d480f1641b6f8515d9ceb862363f3258 192 PANTHER PTHR14969 25 190 4.3E-32 T 21-04-2016 SPH21_RS20160 d480f1641b6f8515d9ceb862363f3258 192 SUPERFAMILY SSF48317 5 186 1.2E-40 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS20160 d480f1641b6f8515d9ceb862363f3258 192 SMART SM00014 79 188 6.9E-25 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82866 293 503 6.41E-31 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 Gene3D G3DSA:3.30.70.1430 45 141 9.9E-19 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PRINTS PR00702 Acriflavin resistance protein family signature 476 499 2.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PRINTS PR00702 Acriflavin resistance protein family signature 549 566 2.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PRINTS PR00702 Acriflavin resistance protein family signature 361 382 2.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PRINTS PR00702 Acriflavin resistance protein family signature 43 61 2.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PRINTS PR00702 Acriflavin resistance protein family signature 334 357 2.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PRINTS PR00702 Acriflavin resistance protein family signature 15 39 2.3E-25 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PANTHER PTHR32063 5 1019 0.0 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82693 563 662 2.98E-5 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 Pfam PF00873 AcrB/AcrD/AcrF family 9 1024 8.2E-236 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82693 270 328 1.31E-12 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 TIGRFAM TIGR00914 2A0601: heavy metal efflux pump, CzcA family 5 1030 6.3E-269 T 21-04-2016 IPR004763 Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA GO:0006812|GO:0008324|GO:0016021 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 Gene3D G3DSA:3.30.2090.10 187 267 5.2E-15 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 Gene3D G3DSA:3.30.2090.10 720 805 7.7E-18 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82866 803 1029 7.72E-47 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82714 187 267 9.42E-14 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 PANTHER PTHR32063:SF12 5 1019 0.0 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82693 46 128 2.51E-16 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82693 144 184 1.31E-12 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 Gene3D G3DSA:1.10.3850.10 811 1028 8.4E-52 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 Gene3D G3DSA:1.10.3850.10 286 504 1.2E-47 T 21-04-2016 SPH21_RS19700 b111029e4b52b1566db92ea0a7d68188 1030 SUPERFAMILY SSF82714 720 804 1.83E-16 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS19605 63600bccc523553be580de777979204f 444 TIGRFAM TIGR03356 BGL: beta-galactosidase 7 438 9.6E-168 T 21-04-2016 IPR017736 Glycoside hydrolase, family 1, beta-glucosidase GO:0008422|GO:0030245 KEGG: 00460+3.2.1.21|KEGG: 00500+3.2.1.21|KEGG: 00940+3.2.1.21|MetaCyc: PWY-3121|MetaCyc: PWY-5176|MetaCyc: PWY-6002|MetaCyc: PWY-6788|MetaCyc: PWY-7089|MetaCyc: PWY-7091|MetaCyc: PWY-7092 SPH21_RS19605 63600bccc523553be580de777979204f 444 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 10 24 - T 21-04-2016 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site SPH21_RS19605 63600bccc523553be580de777979204f 444 PANTHER PTHR10353:SF36 1 444 3.9E-169 T 21-04-2016 SPH21_RS19605 63600bccc523553be580de777979204f 444 SUPERFAMILY SSF51445 6 443 3.48E-149 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS19605 63600bccc523553be580de777979204f 444 PRINTS PR00131 Glycosyl hydrolase family 1 signature 351 359 5.0E-20 T 21-04-2016 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SPH21_RS19605 63600bccc523553be580de777979204f 444 PRINTS PR00131 Glycosyl hydrolase family 1 signature 371 382 5.0E-20 T 21-04-2016 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SPH21_RS19605 63600bccc523553be580de777979204f 444 PRINTS PR00131 Glycosyl hydrolase family 1 signature 392 409 5.0E-20 T 21-04-2016 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SPH21_RS19605 63600bccc523553be580de777979204f 444 PRINTS PR00131 Glycosyl hydrolase family 1 signature 285 299 5.0E-20 T 21-04-2016 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SPH21_RS19605 63600bccc523553be580de777979204f 444 PRINTS PR00131 Glycosyl hydrolase family 1 signature 416 428 5.0E-20 T 21-04-2016 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SPH21_RS19605 63600bccc523553be580de777979204f 444 ProSitePatterns PS00572 Glycosyl hydrolases family 1 active site. 351 359 - T 21-04-2016 IPR018120 Glycoside hydrolase family 1, active site SPH21_RS19605 63600bccc523553be580de777979204f 444 Pfam PF00232 Glycosyl hydrolase family 1 5 441 1.2E-148 T 21-04-2016 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SPH21_RS19605 63600bccc523553be580de777979204f 444 Gene3D G3DSA:3.20.20.80 6 443 4.2E-150 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS19605 63600bccc523553be580de777979204f 444 PANTHER PTHR10353 1 444 3.9E-169 T 21-04-2016 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SPH21_RS00835 2b6e026a73aecae8e7e2f72fa4b7ba86 510 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 50 207 6.1E-26 T 21-04-2016 SPH21_RS13935 a8df249d25e597b281959ad6213e73b3 398 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 88 384 4.0E-36 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS13935 a8df249d25e597b281959ad6213e73b3 398 Gene3D G3DSA:2.40.50.100 116 147 2.5E-7 T 21-04-2016 SPH21_RS13935 a8df249d25e597b281959ad6213e73b3 398 Gene3D G3DSA:2.40.50.100 206 236 2.5E-7 T 21-04-2016 SPH21_RS13935 a8df249d25e597b281959ad6213e73b3 398 SUPERFAMILY SSF111369 113 319 8.37E-11 T 21-04-2016 SPH21_RS13935 a8df249d25e597b281959ad6213e73b3 398 PANTHER PTHR30097 35 392 4.4E-65 T 21-04-2016 SPH21_RS13935 a8df249d25e597b281959ad6213e73b3 398 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 96 311 5.4E-49 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS13935 a8df249d25e597b281959ad6213e73b3 398 PANTHER PTHR30097:SF3 35 392 4.4E-65 T 21-04-2016 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 Gene3D G3DSA:3.30.565.10 301 451 6.5E-30 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 Pfam PF00512 His Kinase A (phospho-acceptor) domain 231 296 2.4E-10 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 SMART SM00387 345 454 1.0E-22 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 SUPERFAMILY SSF47384 214 296 5.49E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 SMART SM00388 231 297 6.3E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 SMART SM00304 176 230 3.9E-6 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 Gene3D G3DSA:1.10.287.130 223 292 1.1E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 347 451 1.4E-17 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 PANTHER PTHR24423 10 22 2.8E-44 T 21-04-2016 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 PANTHER PTHR24423 210 451 2.8E-44 T 21-04-2016 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 Pfam PF00672 HAMP domain 156 226 5.5E-11 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 SUPERFAMILY SSF55874 299 451 2.75E-29 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 399 409 7.9E-7 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 438 451 7.9E-7 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 381 395 7.9E-7 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS08110 3759d8bb3fd648807ba858be4b40a220 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 414 432 7.9E-7 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 Hamap MF_01928 N5-carboxyaminoimidazole ribonucleotide synthase [purK]. 10 362 38.539 T 21-04-2016 IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit GO:0004638|GO:0006189 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 Pfam PF02222 ATP-grasp domain 116 280 2.9E-42 T 21-04-2016 IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type UniPathway: UPA00074 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 Gene3D G3DSA:3.30.470.20 160 378 2.3E-73 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 TIGRFAM TIGR01161 purK: phosphoribosylaminoimidazole carboxylase, ATPase subunit 11 364 3.7E-113 T 21-04-2016 IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit GO:0004638|GO:0006189 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 SUPERFAMILY SSF52440 8 104 1.19E-24 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 PANTHER PTHR11609:SF5 10 367 6.6E-131 T 21-04-2016 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 Gene3D G3DSA:3.30.1490.20 117 159 2.0E-4 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 Gene3D G3DSA:3.40.50.20 10 115 2.1E-34 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 SUPERFAMILY SSF51246 307 378 8.63E-15 T 21-04-2016 IPR011054 Rudiment single hybrid motif SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 SUPERFAMILY SSF56059 107 301 1.77E-47 T 21-04-2016 SPH21_RS15825 413283bc5f2d2f3e7f9a349b7e770b0c 380 PANTHER PTHR11609 10 367 6.6E-131 T 21-04-2016 SPH21_RS12745 1ff764d8196eefdfd1163f7123aad672 355 PANTHER PTHR22893 1 353 8.9E-171 T 21-04-2016 SPH21_RS12745 1ff764d8196eefdfd1163f7123aad672 355 SUPERFAMILY SSF51395 1 350 1.92E-120 T 21-04-2016 SPH21_RS12745 1ff764d8196eefdfd1163f7123aad672 355 Gene3D G3DSA:3.20.20.70 1 350 3.4E-131 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS12745 1ff764d8196eefdfd1163f7123aad672 355 PANTHER PTHR22893:SF7 1 353 8.9E-171 T 21-04-2016 SPH21_RS12745 1ff764d8196eefdfd1163f7123aad672 355 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 3 339 1.2E-75 T 21-04-2016 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 PANTHER PTHR16301:SF0 5 196 6.2E-50 T 21-04-2016 SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 ProSitePatterns PS00910 Uncharacterized protein family UPF0029 signature. 82 111 - T 21-04-2016 IPR020569 Uncharacterised protein family UPF0029, Impact, conserved site SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 Pfam PF01205 Uncharacterized protein family UPF0029 22 126 2.2E-29 T 21-04-2016 IPR001498 Impact, N-terminal SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 Gene3D G3DSA:3.30.230.30 8 135 2.5E-43 T 21-04-2016 IPR001498 Impact, N-terminal SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 SUPERFAMILY SSF54211 7 134 1.67E-39 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 Gene3D G3DSA:3.30.70.240 141 199 1.7E-5 T 21-04-2016 IPR000640 Translation elongation factor EFG, V domain SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 SUPERFAMILY SSF54980 140 196 9.21E-5 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS16895 1d6c5d5702c887a309fedbeefc544a57 205 PANTHER PTHR16301 5 196 6.2E-50 T 21-04-2016 IPR023582 Impact family SPH21_RS17055 96dd489758e8cf39a31b45fe18258d6a 300 Gene3D G3DSA:2.40.440.10 130 223 4.2E-9 T 21-04-2016 SPH21_RS17055 96dd489758e8cf39a31b45fe18258d6a 300 Pfam PF03734 L,D-transpeptidase catalytic domain 123 242 1.3E-15 T 21-04-2016 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 UniPathway: UPA00219 SPH21_RS17055 96dd489758e8cf39a31b45fe18258d6a 300 SUPERFAMILY SSF141523 121 223 3.4E-16 T 21-04-2016 SPH21_RS16970 0d1b4eaa4f3d0ff0761845d37f9313e3 668 Gene3D G3DSA:2.120.10.30 76 294 2.3E-17 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS16970 0d1b4eaa4f3d0ff0761845d37f9313e3 668 Pfam PF01103 Surface antigen 392 583 1.3E-6 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS16970 0d1b4eaa4f3d0ff0761845d37f9313e3 668 SUPERFAMILY SSF69322 52 295 1.18E-20 T 21-04-2016 SPH21_RS11480 3b18cfba126fcd5a1efbaa7c5ab6c1d0 342 Gene3D G3DSA:3.40.50.2300 259 341 1.4E-5 T 21-04-2016 SPH21_RS11480 3b18cfba126fcd5a1efbaa7c5ab6c1d0 342 SUPERFAMILY SSF46785 13 93 4.21E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11480 3b18cfba126fcd5a1efbaa7c5ab6c1d0 342 Gene3D G3DSA:1.10.10.10 11 84 1.0E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS11480 3b18cfba126fcd5a1efbaa7c5ab6c1d0 342 SUPERFAMILY SSF53822 122 341 3.59E-12 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS11480 3b18cfba126fcd5a1efbaa7c5ab6c1d0 342 Pfam PF00392 Bacterial regulatory proteins, gntR family 21 83 2.6E-5 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS00150 2eeff6c06ba4f166066f3a2ac1adf4ad 283 SUPERFAMILY SSF53067 1 105 6.47E-28 T 21-04-2016 SPH21_RS00150 2eeff6c06ba4f166066f3a2ac1adf4ad 283 PANTHER PTHR12862 1 199 4.3E-12 T 21-04-2016 SPH21_RS00150 2eeff6c06ba4f166066f3a2ac1adf4ad 283 SUPERFAMILY SSF53067 108 272 5.5E-36 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 PANTHER PTHR22762 557 686 2.2E-68 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 PANTHER PTHR22762 181 537 2.2E-68 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 PANTHER PTHR22762 81 156 2.2E-68 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 Pfam PF17137 Domain of unknown function (DUF5110) 646 701 2.4E-13 T 21-04-2016 IPR033403 Domain of unknown function DUF5110 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 PANTHER PTHR22762:SF7 557 686 2.2E-68 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 PANTHER PTHR22762:SF7 181 537 2.2E-68 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 PANTHER PTHR22762:SF7 81 156 2.2E-68 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 Pfam PF01055 Glycosyl hydrolases family 31 199 628 5.6E-74 T 21-04-2016 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 SUPERFAMILY SSF74650 79 206 7.22E-16 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 SUPERFAMILY SSF51011 559 623 1.29E-15 T 21-04-2016 SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 Pfam PF13802 Galactose mutarotase-like 94 150 6.5E-7 T 21-04-2016 IPR025887 Glycoside hydrolase family 31, N-terminal domain SPH21_RS14250 6a137818c016fb3ffbf06abf02de6f63 715 SUPERFAMILY SSF51445 209 524 4.21E-32 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01080 d0cfe20854daa1b14e14312d9fa7b539 202 SUPERFAMILY SSF55008 124 199 3.93E-14 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01080 d0cfe20854daa1b14e14312d9fa7b539 202 Pfam PF00403 Heavy-metal-associated domain 131 193 3.7E-9 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS01080 d0cfe20854daa1b14e14312d9fa7b539 202 Gene3D G3DSA:3.30.70.100 130 199 4.5E-15 T 21-04-2016 SPH21_RS01080 d0cfe20854daa1b14e14312d9fa7b539 202 Pfam PF02411 MerT mercuric transport protein 1 111 1.6E-10 T 21-04-2016 IPR003457 Mercuric transport protein MerT GO:0015097|GO:0015694|GO:0016020 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 Gene3D G3DSA:3.30.1120.10 416 468 2.7E-20 T 21-04-2016 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 Gene3D G3DSA:3.30.1120.10 358 376 2.7E-20 T 21-04-2016 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 PANTHER PTHR10342:SF141 1 464 2.3E-138 T 21-04-2016 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 PANTHER PTHR10342 1 464 2.3E-138 T 21-04-2016 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 Pfam PF00884 Sulfatase 43 315 7.4E-44 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 SUPERFAMILY SSF53649 414 459 6.15E-100 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 SUPERFAMILY SSF53649 41 374 6.15E-100 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS21360 8aa512abb4c6a2f8334111085989072b 473 Gene3D G3DSA:3.40.720.10 41 357 3.5E-73 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 Pfam PF03462 PCRF domain 13 136 2.0E-44 T 21-04-2016 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 SMART SM00937 3 111 1.4E-37 T 21-04-2016 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 PANTHER PTHR11075 12 280 1.3E-133 T 21-04-2016 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 Pfam PF00472 RF-1 domain 145 254 3.1E-37 T 21-04-2016 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 PANTHER PTHR11075:SF6 12 280 1.3E-133 T 21-04-2016 IPR004374 Peptide chain release factor 2 GO:0005737|GO:0006415|GO:0016149 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 161 177 - T 21-04-2016 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 SUPERFAMILY SSF75620 11 280 2.62E-110 T 21-04-2016 SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 Gene3D G3DSA:3.30.160.20 144 221 7.1E-32 T 21-04-2016 IPR014720 Double-stranded RNA-binding domain SPH21_RS03370 a7681db623ed4a3ba4e25474840c3ea9 284 TIGRFAM TIGR00020 prfB: peptide chain release factor 2 12 278 2.2E-121 T 21-04-2016 IPR004374 Peptide chain release factor 2 GO:0005737|GO:0006415|GO:0016149 SPH21_RS18960 c50210770d4b9bd17f217821c307ae6e 247 SUPERFAMILY SSF81301 15 142 4.58E-13 T 21-04-2016 SPH21_RS18960 c50210770d4b9bd17f217821c307ae6e 247 Pfam PF09970 Nucleotidyl transferase of unknown function (DUF2204) 16 147 1.6E-7 T 21-04-2016 IPR018700 Protein of unknown function DUF2204 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 SUPERFAMILY SSF103473 14 202 3.53E-27 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS04975 936728dde671ec696021c5584c086d56 495 SUPERFAMILY SSF103473 264 490 3.53E-27 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS04975 936728dde671ec696021c5584c086d56 495 Pfam PF00854 POT family 89 442 2.4E-46 T 21-04-2016 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 PANTHER PTHR11654:SF119 261 490 8.5E-88 T 21-04-2016 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 PANTHER PTHR11654:SF119 7 221 8.5E-88 T 21-04-2016 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 PANTHER PTHR11654 261 490 8.5E-88 T 21-04-2016 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 PANTHER PTHR11654 7 221 8.5E-88 T 21-04-2016 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 Gene3D G3DSA:1.20.1250.20 18 198 7.1E-18 T 21-04-2016 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 TIGRFAM TIGR00924 yjdL_sub1_fam: amino acid/peptide transporter (Peptide:H+ symporter) 16 489 1.5E-94 T 21-04-2016 IPR005279 Dipeptide/tripeptide permease GO:0015197|GO:0015833|GO:0016020 SPH21_RS04975 936728dde671ec696021c5584c086d56 495 ProSitePatterns PS01023 PTR2 family proton/oligopeptide symporters signature 2. 147 159 - T 21-04-2016 IPR018456 PTR2 family proton/oligopeptide symporter, conserved site GO:0005215|GO:0006857|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS15775 dd37c23aa7fe68ba2ef1d954a0c99925 291 Gene3D G3DSA:1.20.120.20 4 93 2.3E-4 T 21-04-2016 SPH21_RS10115 37dda093c089ace71685de9824586514 324 SUPERFAMILY SSF52266 46 123 1.03E-10 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS10115 37dda093c089ace71685de9824586514 324 SUPERFAMILY SSF52266 217 306 1.03E-10 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 Gene3D G3DSA:2.60.120.260 212 294 1.3E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 980 1108 2.2E-7 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 SUPERFAMILY SSF49785 212 292 1.07E-5 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 PANTHER PTHR22925 31 422 2.7E-94 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 Pfam PF17132 alpha-L-rhamnosidase 39 693 2.2E-153 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 Pfam PF17132 alpha-L-rhamnosidase 734 939 3.8E-30 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 Gene3D G3DSA:2.60.120.260 984 1117 1.1E-15 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 SUPERFAMILY SSF49785 981 1140 2.24E-21 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11575 2a255fa94051972d80fa90d90aeb5284 1146 PANTHER PTHR22925:SF42 31 422 2.7E-94 T 21-04-2016 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 Gene3D G3DSA:2.40.170.20 168 701 8.2E-117 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 PANTHER PTHR32552:SF10 25 703 1.1E-113 T 21-04-2016 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 Gene3D G3DSA:2.170.130.10 32 160 4.8E-29 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 TIGRFAM TIGR01783 TonB-siderophor: TonB-dependent siderophore receptor 55 701 1.1E-83 T 21-04-2016 IPR010105 TonB-dependent siderophore receptor GO:0004872|GO:0005506|GO:0015891 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 SUPERFAMILY SSF56935 25 701 9.71E-116 T 21-04-2016 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 PANTHER PTHR32552 25 703 1.1E-113 T 21-04-2016 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 Pfam PF00593 TonB dependent receptor 466 701 4.0E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12755 1afe0a2acb4ee219b354746c61af858d 704 Pfam PF07715 TonB-dependent Receptor Plug Domain 52 153 4.6E-14 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS01230 2541798896102576fe4ae1f4181742f2 113 Pfam PF13571 Domain of unknown function (DUF4133) 7 97 1.0E-33 T 21-04-2016 IPR025407 Protein of unknown function DUF4133 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 ProSitePatterns PS00217 Sugar transport proteins signature 2. 112 137 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 PRINTS PR01036 Tetracycline resistance protein TetB signature 110 130 2.3E-5 T 21-04-2016 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 PRINTS PR01036 Tetracycline resistance protein TetB signature 140 164 2.3E-5 T 21-04-2016 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 PRINTS PR01036 Tetracycline resistance protein TetB signature 19 43 2.3E-5 T 21-04-2016 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 PANTHER PTHR23501 12 516 1.3E-137 T 21-04-2016 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 16 504 2.3E-129 T 21-04-2016 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 PANTHER PTHR23501:SF69 12 516 1.3E-137 T 21-04-2016 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 Pfam PF07690 Major Facilitator Superfamily 21 417 1.4E-60 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 SUPERFAMILY SSF103473 254 427 2.09E-70 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 SUPERFAMILY SSF103473 487 516 2.09E-70 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 SUPERFAMILY SSF103473 7 200 2.09E-70 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 Gene3D G3DSA:1.20.1250.20 269 428 3.3E-15 T 21-04-2016 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 Gene3D G3DSA:1.20.1250.20 19 198 2.4E-34 T 21-04-2016 SPH21_RS08295 3e0bf271b9bd06965f456f6071411e6f 523 Gene3D G3DSA:1.20.1250.20 488 513 3.3E-15 T 21-04-2016 SPH21_RS25230 c800cdd68c3cb9c9191baf44c8fd0d34 238 SMART SM00479 4 190 2.0E-6 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS25230 c800cdd68c3cb9c9191baf44c8fd0d34 238 Pfam PF00929 Exonuclease 6 180 2.3E-9 T 21-04-2016 IPR013520 Exonuclease, RNase T/DNA polymerase III SPH21_RS25230 c800cdd68c3cb9c9191baf44c8fd0d34 238 Gene3D G3DSA:3.30.420.10 2 186 5.4E-23 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS25230 c800cdd68c3cb9c9191baf44c8fd0d34 238 SUPERFAMILY SSF53098 4 199 1.9E-30 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS22735 bd7fbe148a23ffb9e9059850470e7634 105 Pfam PF09357 RteC protein 61 97 9.3E-10 T 21-04-2016 IPR018534 Tetracycline regulation of excision, RteC SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 Pfam PF01479 S4 domain 187 233 2.3E-10 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 Gene3D G3DSA:3.10.290.10 186 248 1.4E-23 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 TIGRFAM TIGR00093 TIGR00093: pseudouridine synthase 251 409 1.5E-45 T 21-04-2016 IPR000748 Pseudouridine synthase, RsuA/RluB/E/F GO:0001522|GO:0003723|GO:0009451|GO:0016866 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 SUPERFAMILY SSF55120 245 414 2.56E-37 T 21-04-2016 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 SUPERFAMILY SSF55174 155 288 5.89E-20 T 21-04-2016 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 PANTHER PTHR21600:SF2 104 416 4.9E-105 T 21-04-2016 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 Pfam PF00849 RNA pseudouridylate synthase 247 378 1.3E-16 T 21-04-2016 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 PANTHER PTHR21600 104 416 4.9E-105 T 21-04-2016 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 ProSitePatterns PS01149 Rsu family of pseudouridine synthase signature. 285 299 - T 21-04-2016 IPR018496 Pseudouridine synthase, RsuA/RluB/E/F, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0016866 SPH21_RS25960 99a2a88d456539a4101593e681fdf14e 421 SMART SM00363 186 248 1.8E-10 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 Gene3D G3DSA:3.90.25.10 181 233 3.7E-44 T 21-04-2016 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 Gene3D G3DSA:3.90.25.10 268 334 3.7E-44 T 21-04-2016 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 Gene3D G3DSA:3.40.50.720 1 180 2.8E-45 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 TIGRFAM TIGR01179 galE: UDP-glucose 4-epimerase GalE 3 337 7.1E-118 T 21-04-2016 IPR005886 UDP-glucose 4-epimerase GalE GO:0003978|GO:0006012 KEGG: 00052+5.1.3.2|KEGG: 00520+5.1.3.2|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6397|MetaCyc: PWY-6527|MetaCyc: PWY-7328|MetaCyc: PWY-7344|UniPathway: UPA00214 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 PANTHER PTHR10366:SF39 3 333 2.8E-121 T 21-04-2016 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 PANTHER PTHR10366 3 333 2.8E-121 T 21-04-2016 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 SUPERFAMILY SSF51735 1 333 7.68E-85 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 PRINTS PR01713 Nucleotide sugar epimerase signature 299 316 7.1E-6 T 21-04-2016 IPR008089 Nucleotide sugar epimerase GO:0005975|GO:0016857 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 PRINTS PR01713 Nucleotide sugar epimerase signature 260 275 7.1E-6 T 21-04-2016 IPR008089 Nucleotide sugar epimerase GO:0005975|GO:0016857 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 PRINTS PR01713 Nucleotide sugar epimerase signature 232 247 7.1E-6 T 21-04-2016 IPR008089 Nucleotide sugar epimerase GO:0005975|GO:0016857 SPH21_RS05155 9da030285c15ee8e26fd9ea9b3d403d7 343 Pfam PF16363 GDP-mannose 4,6 dehydratase 5 327 4.0E-55 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14675 265ab1ae881e194e377766f94c95262d 553 SUPERFAMILY SSF48452 19 553 2.02E-115 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14675 265ab1ae881e194e377766f94c95262d 553 Gene3D G3DSA:1.25.40.10 197 304 4.7E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14675 265ab1ae881e194e377766f94c95262d 553 Gene3D G3DSA:1.25.40.10 379 472 4.7E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14675 265ab1ae881e194e377766f94c95262d 553 Pfam PF07980 SusD family 287 553 6.3E-53 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14675 265ab1ae881e194e377766f94c95262d 553 Pfam PF14322 Starch-binding associating with outer membrane 23 217 1.5E-17 T 21-04-2016 SPH21_RS11195 efd554d07013e00664db98644e2abcb8 210 Gene3D G3DSA:1.10.150.240 18 84 2.7E-22 T 21-04-2016 IPR023198 Phosphoglycolate phosphatase, domain 2 SPH21_RS11195 efd554d07013e00664db98644e2abcb8 210 Pfam PF13419 Haloacid dehalogenase-like hydrolase 92 191 7.0E-8 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS11195 efd554d07013e00664db98644e2abcb8 210 Gene3D G3DSA:3.40.50.1000 85 199 2.3E-21 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS11195 efd554d07013e00664db98644e2abcb8 210 SUPERFAMILY SSF56784 6 199 3.44E-27 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS11195 efd554d07013e00664db98644e2abcb8 210 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 142 191 2.7E-11 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 Pfam PF00958 GMP synthase C terminal domain 425 515 6.1E-43 T 21-04-2016 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|UniPathway: UPA00189 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 TIGRFAM TIGR00888 guaA_Nterm: GMP synthase (glutamine-hydrolyzing), N-terminal domain 5 190 3.4E-65 T 21-04-2016 IPR004739 GMP synthase, N-terminal GO:0003922|GO:0005524|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|UniPathway: UPA00189 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 TIGRFAM TIGR00884 guaA_Cterm: GMP synthase (glutamine-hydrolyzing), C-terminal domain 199 516 2.5E-138 T 21-04-2016 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|UniPathway: UPA00189 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 SUPERFAMILY SSF52402 180 437 2.87E-53 T 21-04-2016 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 Gene3D G3DSA:3.40.50.620 210 385 1.6E-50 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 PRINTS PR00096 Glutamine amidotransferase superfamily signature 74 85 1.2E-5 T 21-04-2016 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 PRINTS PR00096 Glutamine amidotransferase superfamily signature 163 176 1.2E-5 T 21-04-2016 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 PRINTS PR00096 Glutamine amidotransferase superfamily signature 47 56 1.2E-5 T 21-04-2016 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 Pfam PF00117 Glutamine amidotransferase class-I 7 186 7.2E-34 T 21-04-2016 IPR017926 Glutamine amidotransferase Reactome: REACT_1698 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 SUPERFAMILY SSF54810 396 516 6.41E-51 T 21-04-2016 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 SUPERFAMILY SSF52317 4 195 7.97E-49 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 Pfam PF02540 NAD synthase 209 276 4.1E-6 T 21-04-2016 IPR022310 NAD/GMP synthase SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 PANTHER PTHR11922 1 513 4.6E-266 T 21-04-2016 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 Hamap MF_00344 GMP synthase [glutamine-hydrolyzing] [guaA]. 2 516 51.561 T 21-04-2016 IPR022955 GMP synthase GO:0003922|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|UniPathway: UPA00189 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 PANTHER PTHR11922:SF2 1 513 4.6E-266 T 21-04-2016 SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 Gene3D G3DSA:3.40.50.880 2 209 5.8E-56 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS11025 899624b1a4848aa985c6b9856fa57f4f 516 Gene3D G3DSA:3.30.300.10 392 516 6.3E-52 T 21-04-2016 SPH21_RS16295 de200d59e9f1b462cf5cb61599a8d647 398 Pfam PF01548 Transposase 4 145 8.6E-19 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS16295 de200d59e9f1b462cf5cb61599a8d647 398 Pfam PF02371 Transposase IS116/IS110/IS902 family 247 330 1.4E-18 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS16295 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055:SF3 189 369 3.5E-37 T 21-04-2016 SPH21_RS16295 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055:SF3 1 151 3.5E-37 T 21-04-2016 SPH21_RS16295 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055 189 369 3.5E-37 T 21-04-2016 SPH21_RS16295 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055 1 151 3.5E-37 T 21-04-2016 SPH21_RS24545 de200d59e9f1b462cf5cb61599a8d647 398 Pfam PF01548 Transposase 4 145 8.6E-19 T 21-04-2016 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SPH21_RS24545 de200d59e9f1b462cf5cb61599a8d647 398 Pfam PF02371 Transposase IS116/IS110/IS902 family 247 330 1.4E-18 T 21-04-2016 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SPH21_RS24545 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055:SF3 189 369 3.5E-37 T 21-04-2016 SPH21_RS24545 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055:SF3 1 151 3.5E-37 T 21-04-2016 SPH21_RS24545 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055 189 369 3.5E-37 T 21-04-2016 SPH21_RS24545 de200d59e9f1b462cf5cb61599a8d647 398 PANTHER PTHR33055 1 151 3.5E-37 T 21-04-2016 SPH21_RS02705 8e34018f5b11ffd8c00308e81d7fa9a9 264 Pfam PF02673 Bacitracin resistance protein BacA 6 249 2.0E-78 T 21-04-2016 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SPH21_RS02705 8e34018f5b11ffd8c00308e81d7fa9a9 264 TIGRFAM TIGR00753 undec_PP_bacA: undecaprenyl-diphosphatase UppP 6 248 1.8E-67 T 21-04-2016 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SPH21_RS02705 8e34018f5b11ffd8c00308e81d7fa9a9 264 Hamap MF_01006 Undecaprenyl-diphosphatase [uppP]. 1 255 17.695 T 21-04-2016 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SPH21_RS02705 8e34018f5b11ffd8c00308e81d7fa9a9 264 PANTHER PTHR30622 1 264 2.3E-102 T 21-04-2016 SPH21_RS02705 8e34018f5b11ffd8c00308e81d7fa9a9 264 PANTHER PTHR30622:SF3 1 264 2.3E-102 T 21-04-2016 SPH21_RS22625 796e9edcb368ce5e8b763af2843fc07c 435 SUPERFAMILY SSF103473 3 417 1.18E-76 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS22625 796e9edcb368ce5e8b763af2843fc07c 435 Gene3D G3DSA:1.20.1250.20 226 418 3.3E-24 T 21-04-2016 SPH21_RS22625 796e9edcb368ce5e8b763af2843fc07c 435 PANTHER PTHR11662:SF18 2 421 1.3E-123 T 21-04-2016 SPH21_RS22625 796e9edcb368ce5e8b763af2843fc07c 435 PANTHER PTHR11662 2 421 1.3E-123 T 21-04-2016 SPH21_RS22625 796e9edcb368ce5e8b763af2843fc07c 435 Gene3D G3DSA:1.20.1250.20 3 192 2.0E-47 T 21-04-2016 SPH21_RS22625 796e9edcb368ce5e8b763af2843fc07c 435 Pfam PF07690 Major Facilitator Superfamily 14 382 7.0E-54 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS07155 496eb71192a8d8a680667b2d89d90a17 249 Gene3D G3DSA:3.60.21.10 6 151 1.0E-22 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS07155 496eb71192a8d8a680667b2d89d90a17 249 Gene3D G3DSA:3.60.21.10 194 247 1.0E-22 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS07155 496eb71192a8d8a680667b2d89d90a17 249 Pfam PF00149 Calcineurin-like phosphoesterase 6 210 2.4E-8 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS07155 496eb71192a8d8a680667b2d89d90a17 249 SUPERFAMILY SSF56300 5 234 4.78E-23 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS07155 496eb71192a8d8a680667b2d89d90a17 249 PANTHER PTHR34990 5 247 1.6E-49 T 21-04-2016 SPH21_RS07155 496eb71192a8d8a680667b2d89d90a17 249 PANTHER PTHR34990:SF1 5 247 1.6E-49 T 21-04-2016 SPH21_RS12855 bf6fd9236c56a9c515f3ced8cec9845e 294 Gene3D G3DSA:3.40.50.1820 22 284 8.9E-44 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12855 bf6fd9236c56a9c515f3ced8cec9845e 294 Pfam PF00561 alpha/beta hydrolase fold 52 186 7.7E-15 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS12855 bf6fd9236c56a9c515f3ced8cec9845e 294 SUPERFAMILY SSF53474 21 284 2.84E-45 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12855 bf6fd9236c56a9c515f3ced8cec9845e 294 PANTHER PTHR10992 31 285 6.3E-32 T 21-04-2016 SPH21_RS12855 bf6fd9236c56a9c515f3ced8cec9845e 294 PRINTS PR00111 Alpha/beta hydrolase fold signature 134 147 1.9E-8 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS12855 bf6fd9236c56a9c515f3ced8cec9845e 294 PRINTS PR00111 Alpha/beta hydrolase fold signature 76 91 1.9E-8 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS12855 bf6fd9236c56a9c515f3ced8cec9845e 294 PRINTS PR00111 Alpha/beta hydrolase fold signature 120 133 1.9E-8 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS20970 4e37f5429e4a8444d0259a3c6f93c55a 625 Gene3D G3DSA:1.25.40.10 206 357 7.5E-26 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20970 4e37f5429e4a8444d0259a3c6f93c55a 625 Gene3D G3DSA:1.25.40.10 442 531 7.5E-26 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20970 4e37f5429e4a8444d0259a3c6f93c55a 625 Pfam PF07980 SusD family 333 623 2.9E-56 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS20970 4e37f5429e4a8444d0259a3c6f93c55a 625 Pfam PF14322 Starch-binding associating with outer membrane 21 222 3.1E-23 T 21-04-2016 SPH21_RS20970 4e37f5429e4a8444d0259a3c6f93c55a 625 SUPERFAMILY SSF48452 16 230 5.08E-105 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20970 4e37f5429e4a8444d0259a3c6f93c55a 625 SUPERFAMILY SSF48452 591 623 5.08E-105 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20970 4e37f5429e4a8444d0259a3c6f93c55a 625 SUPERFAMILY SSF48452 260 558 5.08E-105 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12020 1b8d4932ceac167cd97f7ef971d29006 345 Gene3D G3DSA:3.40.50.2000 35 163 1.5E-13 T 21-04-2016 SPH21_RS12020 1b8d4932ceac167cd97f7ef971d29006 345 PANTHER PTHR30160:SF1 34 321 7.8E-21 T 21-04-2016 SPH21_RS12020 1b8d4932ceac167cd97f7ef971d29006 345 SUPERFAMILY SSF53756 35 343 3.14E-43 T 21-04-2016 SPH21_RS12020 1b8d4932ceac167cd97f7ef971d29006 345 PANTHER PTHR30160 34 321 7.8E-21 T 21-04-2016 SPH21_RS12020 1b8d4932ceac167cd97f7ef971d29006 345 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 110 326 1.2E-15 T 21-04-2016 IPR002201 Glycosyl transferase, family 9 GO:0008152|GO:0016757 SPH21_RS12020 1b8d4932ceac167cd97f7ef971d29006 345 Gene3D G3DSA:3.40.50.2000 203 327 2.0E-15 T 21-04-2016 SPH21_RS07875 6b6048688f9930a185eb1bca64ae4eae 170 PANTHER PTHR10371 7 168 1.3E-75 T 21-04-2016 SPH21_RS07875 6b6048688f9930a185eb1bca64ae4eae 170 PIRSF PIRSF000216 3 170 5.5E-64 T 21-04-2016 IPR002023 NADH-quinone oxidoreductase subunit E-like GO:0016491|GO:0055114 SPH21_RS07875 6b6048688f9930a185eb1bca64ae4eae 170 TIGRFAM TIGR01958 nuoE_fam: NADH-quinone oxidoreductase, E subunit 20 168 1.9E-51 T 21-04-2016 IPR002023 NADH-quinone oxidoreductase subunit E-like GO:0016491|GO:0055114 SPH21_RS07875 6b6048688f9930a185eb1bca64ae4eae 170 Gene3D G3DSA:3.40.30.10 86 166 1.0E-10 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07875 6b6048688f9930a185eb1bca64ae4eae 170 SUPERFAMILY SSF52833 13 169 1.34E-53 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS07875 6b6048688f9930a185eb1bca64ae4eae 170 Pfam PF01257 Thioredoxin-like [2Fe-2S] ferredoxin 21 168 3.1E-53 T 21-04-2016 SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 Pfam PF13229 Right handed beta helix region 111 270 5.8E-14 T 21-04-2016 SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SUPERFAMILY SSF51126 405 523 1.24E-7 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 TIGRFAM TIGR03804 para_beta_helix: parallel beta-helix repeat 191 234 3.4E-8 T 21-04-2016 IPR022441 Parallel beta-helix repeat-2 SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 Gene3D G3DSA:2.160.20.10 41 115 7.3E-22 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 Gene3D G3DSA:2.160.20.10 411 522 5.8E-5 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 Gene3D G3DSA:2.160.20.10 153 366 7.3E-22 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 248 270 880.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 278 309 3300.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 220 242 42.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 439 461 37.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 311 333 3800.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 197 219 0.28 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 415 438 9500.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 135 162 1800.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SMART SM00710 463 484 1500.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 Pfam PF05048 Periplasmic copper-binding protein (NosD) 400 503 3.3E-6 T 21-04-2016 IPR007742 Periplasmic copper-binding protein NosD, beta helix domain SPH21_RS01025 2dd5d9a031febe8b65caeee5ae84e976 557 SUPERFAMILY SSF51126 45 348 1.71E-26 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS05090 f84328b88d519d99bc93f2edafbd0576 120 Gene3D G3DSA:1.20.1440.60 1 117 6.4E-45 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS05090 f84328b88d519d99bc93f2edafbd0576 120 Pfam PF05635 23S rRNA-intervening sequence protein 5 109 5.3E-44 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS05090 f84328b88d519d99bc93f2edafbd0576 120 PANTHER PTHR38471 1 117 4.3E-33 T 21-04-2016 SPH21_RS05090 f84328b88d519d99bc93f2edafbd0576 120 TIGRFAM TIGR02436 TIGR02436: four helix bundle protein 9 115 3.3E-42 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS05090 f84328b88d519d99bc93f2edafbd0576 120 SUPERFAMILY SSF158446 1 112 4.05E-41 T 21-04-2016 SPH21_RS05090 f84328b88d519d99bc93f2edafbd0576 120 PANTHER PTHR38471:SF2 1 117 4.3E-33 T 21-04-2016 SPH21_RS01620 bd24d5fc9d2b6ed54da1a8a534349f5d 346 SUPERFAMILY SSF55909 3 345 1.02E-120 T 21-04-2016 SPH21_RS01620 bd24d5fc9d2b6ed54da1a8a534349f5d 346 Gene3D G3DSA:3.75.10.10 4 345 5.6E-129 T 21-04-2016 SPH21_RS01620 bd24d5fc9d2b6ed54da1a8a534349f5d 346 PANTHER PTHR31377 4 345 2.1E-128 T 21-04-2016 SPH21_RS01620 bd24d5fc9d2b6ed54da1a8a534349f5d 346 PANTHER PTHR31377:SF0 4 345 2.1E-128 T 21-04-2016 SPH21_RS01620 bd24d5fc9d2b6ed54da1a8a534349f5d 346 Pfam PF04371 Porphyromonas-type peptidyl-arginine deiminase 11 344 9.9E-117 T 21-04-2016 IPR007466 Peptidyl-arginine deiminase, Porphyromonas-type GO:0004668|GO:0009446 KEGG: 00330+3.5.3.12|MetaCyc: PWY-43 SPH21_RS04815 9510c8039f9a1be86156d2a169061b55 346 TIGRFAM TIGR00557 pdxA: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 7 339 2.9E-101 T 21-04-2016 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295|UniPathway: UPA00244 SPH21_RS04815 9510c8039f9a1be86156d2a169061b55 346 SUPERFAMILY SSF53659 4 341 3.05E-96 T 21-04-2016 SPH21_RS04815 9510c8039f9a1be86156d2a169061b55 346 Hamap MF_00536 4-hydroxythreonine-4-phosphate dehydrogenase [pdxA]. 3 339 33.193 T 21-04-2016 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295|UniPathway: UPA00244 SPH21_RS04815 9510c8039f9a1be86156d2a169061b55 346 Gene3D G3DSA:3.40.718.10 2 339 1.5E-124 T 21-04-2016 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 SPH21_RS04815 9510c8039f9a1be86156d2a169061b55 346 Pfam PF04166 Pyridoxal phosphate biosynthetic protein PdxA 34 335 1.3E-103 T 21-04-2016 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295|UniPathway: UPA00244 SPH21_RS04815 9510c8039f9a1be86156d2a169061b55 346 PANTHER PTHR30004 1 342 3.0E-136 T 21-04-2016 SPH21_RS04815 9510c8039f9a1be86156d2a169061b55 346 PANTHER PTHR30004:SF6 1 342 3.0E-136 T 21-04-2016 SPH21_RS09655 d7eab95a1fb3e764dc4461e938ea6b97 274 Gene3D G3DSA:3.90.550.10 2 138 4.3E-6 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09655 d7eab95a1fb3e764dc4461e938ea6b97 274 SUPERFAMILY SSF53448 1 192 4.13E-20 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09655 d7eab95a1fb3e764dc4461e938ea6b97 274 Pfam PF00535 Glycosyl transferase family 2 3 137 2.9E-10 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS03080 25126420ccec9553327899bba9fa01eb 277 Gene3D G3DSA:3.20.20.140 1 277 4.3E-70 T 21-04-2016 SPH21_RS03080 25126420ccec9553327899bba9fa01eb 277 PANTHER PTHR21240 1 277 2.4E-63 T 21-04-2016 SPH21_RS03080 25126420ccec9553327899bba9fa01eb 277 PANTHER PTHR21240:SF1 1 277 2.4E-63 T 21-04-2016 SPH21_RS03080 25126420ccec9553327899bba9fa01eb 277 Pfam PF04909 Amidohydrolase 4 277 3.1E-37 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS03080 25126420ccec9553327899bba9fa01eb 277 SUPERFAMILY SSF51556 2 277 7.56E-70 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS03130 b68cfccda57f3568dfbb88029b6bd514 276 Gene3D G3DSA:3.40.50.880 30 270 6.4E-46 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS03130 b68cfccda57f3568dfbb88029b6bd514 276 PANTHER PTHR40469:SF1 4 260 1.2E-38 T 21-04-2016 SPH21_RS03130 b68cfccda57f3568dfbb88029b6bd514 276 Pfam PF06283 Trehalose utilisation 31 250 2.3E-67 T 21-04-2016 IPR029010 ThuA-like domain SPH21_RS03130 b68cfccda57f3568dfbb88029b6bd514 276 SUPERFAMILY SSF52317 30 255 5.49E-45 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS03130 b68cfccda57f3568dfbb88029b6bd514 276 PANTHER PTHR40469 4 260 1.2E-38 T 21-04-2016 SPH21_RS01205 b58064d5394b5faf5096636706120075 403 TIGRFAM TIGR03782 Bac_Flav_CT_J: Bacteroides conjugative transposon TraJ protein 34 353 5.1E-111 T 21-04-2016 IPR022393 Conjugative transposon, TraJ SPH21_RS01205 b58064d5394b5faf5096636706120075 403 Pfam PF07863 Homologues of TraJ from Bacteroides conjugative transposon 306 359 4.5E-18 T 21-04-2016 IPR012424 Conjugative transposon, TraJ, C-terminal SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 PANTHER PTHR11532 510 998 4.8E-206 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 PANTHER PTHR11532 1 196 4.8E-206 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 PANTHER PTHR11532 214 443 4.8E-206 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 PANTHER PTHR11532:SF57 510 998 4.8E-206 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 PANTHER PTHR11532:SF57 1 196 4.8E-206 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 PANTHER PTHR11532:SF57 214 443 4.8E-206 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 Pfam PF13715 CarboxypepD_reg-like domain 29 114 3.4E-24 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 SUPERFAMILY SSF49464 28 124 3.34E-22 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 29 1000 6.3E-216 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 Gene3D G3DSA:2.60.40.1120 29 116 2.3E-21 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 Gene3D G3DSA:2.170.130.10 117 248 2.3E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 223 253 9.0E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 Gene3D G3DSA:2.40.170.20 845 999 2.7E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 Gene3D G3DSA:2.40.170.20 249 285 2.7E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 Gene3D G3DSA:2.40.170.20 317 795 2.7E-59 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 SUPERFAMILY SSF56935 834 880 4.49E-91 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 SUPERFAMILY SSF56935 110 271 4.49E-91 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 SUPERFAMILY SSF56935 431 781 4.49E-91 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 SUPERFAMILY SSF56935 308 396 4.49E-91 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 SUPERFAMILY SSF56935 908 999 4.49E-91 T 21-04-2016 SPH21_RS19375 e6842588e34994d29d1cc795860cc985 1000 Pfam PF07715 TonB-dependent Receptor Plug Domain 123 247 8.8E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 4 21 7.8E-5 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 38 54 7.8E-5 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 72 87 7.8E-5 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 PANTHER PTHR11717 1 135 3.4E-40 T 21-04-2016 SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 4 132 2.7E-23 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 PANTHER PTHR11717:SF18 1 135 3.4E-40 T 21-04-2016 SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 Gene3D G3DSA:3.40.50.270 1 134 3.9E-46 T 21-04-2016 SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 SMART SM00226 2 135 1.1E-46 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS23570 7b6d3751e14f5e087d3df3cbee432d11 145 SUPERFAMILY SSF52788 1 134 1.31E-44 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 Gene3D G3DSA:1.10.357.20 252 434 1.1E-61 T 21-04-2016 IPR006667 SLC41 divalent cation transporters, integral membrane domain GO:0006812|GO:0008324 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 Gene3D G3DSA:1.25.60.10 3 104 1.7E-20 T 21-04-2016 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 Pfam PF00571 CBS domain 176 229 2.1E-9 T 21-04-2016 IPR000644 CBS domain SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 SUPERFAMILY SSF158791 2 106 7.46E-21 T 21-04-2016 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 TIGRFAM TIGR00400 mgtE: magnesium transporter 3 433 4.0E-105 T 21-04-2016 IPR006669 Magnesium transporter MgtE GO:0015095|GO:0015693|GO:0016020 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 SUPERFAMILY SSF161093 253 433 9.81E-51 T 21-04-2016 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 SMART SM00924 7 110 8.9E-23 T 21-04-2016 IPR006668 Magnesium transporter, MgtE intracellular domain SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 SUPERFAMILY SSF54631 110 246 1.89E-25 T 21-04-2016 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 Pfam PF03448 MgtE intracellular N domain 7 108 1.8E-21 T 21-04-2016 IPR006668 Magnesium transporter, MgtE intracellular domain SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 Pfam PF01769 Divalent cation transporter 296 427 7.0E-32 T 21-04-2016 IPR006667 SLC41 divalent cation transporters, integral membrane domain GO:0006812|GO:0008324 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 PANTHER PTHR41394 38 433 2.3E-35 T 21-04-2016 SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 SMART SM00116 181 229 1.9E-6 T 21-04-2016 IPR000644 CBS domain SPH21_RS21270 d5566069a0402b0157010d3f94248e77 438 Gene3D G3DSA:3.10.580.10 105 235 4.2E-17 T 21-04-2016 SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 Gene3D G3DSA:2.30.130.10 1 69 1.5E-20 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 SUPERFAMILY SSF53335 78 390 5.46E-64 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 PANTHER PTHR11061:SF12 1 394 1.6E-105 T 21-04-2016 SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 SUPERFAMILY SSF88697 1 69 5.96E-14 T 21-04-2016 IPR015947 PUA-like domain SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 Gene3D G3DSA:3.40.50.150 185 393 6.9E-56 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 Gene3D G3DSA:3.30.750.80 73 178 1.1E-32 T 21-04-2016 SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 PANTHER PTHR11061 1 394 1.6E-105 T 21-04-2016 SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 Pfam PF10672 S-adenosylmethionine-dependent methyltransferase 166 372 1.9E-21 T 21-04-2016 IPR019614 S-adenosylmethionine-dependent methyltransferase GO:0008168 SPH21_RS05345 f541a79e41439f5809140647da0418d3 394 SMART SM00359 2 87 8.2E-6 T 21-04-2016 IPR002478 PUA domain GO:0003723 SPH21_RS11395 2f34d8fae5f5db4654b2f0c0449ec378 307 SUPERFAMILY SSF75005 65 294 9.03E-29 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS11395 2f34d8fae5f5db4654b2f0c0449ec378 307 Pfam PF00251 Glycosyl hydrolases family 32 N-terminal domain 25 183 1.7E-4 T 21-04-2016 IPR013148 Glycosyl hydrolase family 32, N-terminal SPH21_RS11395 2f34d8fae5f5db4654b2f0c0449ec378 307 Gene3D G3DSA:2.115.10.20 63 275 1.5E-24 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 Gene3D G3DSA:1.20.1250.20 270 469 8.1E-16 T 21-04-2016 SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 SUPERFAMILY SSF103473 4 99 4.05E-69 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 SUPERFAMILY SSF103473 131 475 4.05E-69 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 Gene3D G3DSA:1.20.1250.20 9 229 5.9E-39 T 21-04-2016 SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 PANTHER PTHR11662:SF277 137 473 3.2E-128 T 21-04-2016 SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 PANTHER PTHR11662:SF277 7 99 3.2E-128 T 21-04-2016 SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 Pfam PF07690 Major Facilitator Superfamily 18 420 2.6E-46 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 PANTHER PTHR11662 137 473 3.2E-128 T 21-04-2016 SPH21_RS14395 4894105213017bcc669c99f0f30556a9 480 PANTHER PTHR11662 7 99 3.2E-128 T 21-04-2016 SPH21_RS18870 d24b63d0202aeeb99ecf7bcc9cecb950 197 SUPERFAMILY SSF47384 118 191 1.79E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS18870 d24b63d0202aeeb99ecf7bcc9cecb950 197 Gene3D G3DSA:3.30.450.20 11 130 6.2E-9 T 21-04-2016 SPH21_RS18870 d24b63d0202aeeb99ecf7bcc9cecb950 197 SUPERFAMILY SSF55785 26 121 4.38E-8 T 21-04-2016 IPR000014 PAS domain SPH21_RS18870 d24b63d0202aeeb99ecf7bcc9cecb950 197 Gene3D G3DSA:1.10.287.130 131 191 0.001 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Gene3D G3DSA:3.30.70.380 706 797 2.5E-27 T 21-04-2016 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SUPERFAMILY SSF54991 699 797 2.35E-27 T 21-04-2016 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Gene3D G3DSA:3.30.930.10 500 691 1.0E-42 T 21-04-2016 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SMART SM00874 410 479 9.2E-19 T 21-04-2016 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 TIGRFAM TIGR00472 pheT_bact: phenylalanine--tRNA ligase, beta subunit 1 797 2.7E-253 T 21-04-2016 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SMART SM00896 704 797 4.2E-35 T 21-04-2016 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SUPERFAMILY SSF56037 210 404 9.42E-73 T 21-04-2016 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 PANTHER PTHR10947 2 797 4.3E-257 T 21-04-2016 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Pfam PF03483 B3/4 domain 220 393 1.1E-67 T 21-04-2016 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SUPERFAMILY SSF46955 410 483 1.92E-17 T 21-04-2016 IPR009061 Putative DNA-binding domain SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SMART SM00873 220 393 3.7E-92 T 21-04-2016 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 PANTHER PTHR10947:SF0 2 797 4.3E-257 T 21-04-2016 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SUPERFAMILY SSF50249 43 203 5.43E-43 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Pfam PF01588 Putative tRNA binding domain 48 152 8.1E-24 T 21-04-2016 IPR002547 tRNA-binding domain GO:0000049 Reactome: REACT_71 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Gene3D G3DSA:3.30.56.20 410 483 1.8E-22 T 21-04-2016 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 SUPERFAMILY SSF55681 475 690 1.94E-29 T 21-04-2016 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Pfam PF03484 tRNA synthetase B5 domain 414 479 7.1E-17 T 21-04-2016 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Hamap MF_00283 Phenylalanine--tRNA ligase beta subunit [pheT]. 1 791 41.482 T 21-04-2016 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Gene3D G3DSA:2.40.50.140 45 159 2.8E-39 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Gene3D G3DSA:3.30.56.10 163 192 1.8E-23 T 21-04-2016 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Gene3D G3DSA:3.30.56.10 1 38 1.8E-23 T 21-04-2016 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Gene3D G3DSA:3.50.40.10 211 403 3.9E-84 T 21-04-2016 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 SPH21_RS19635 a475f3a46519a9766dc87b41d77fdc9e 799 Pfam PF03147 Ferredoxin-fold anticodon binding domain 705 797 2.5E-27 T 21-04-2016 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SPH21_RS22325 b0d43a23e8f345da02710110cfc4d5af 255 Pfam PF13847 Methyltransferase domain 29 167 2.2E-20 T 21-04-2016 IPR025714 Methyltransferase domain SPH21_RS22325 b0d43a23e8f345da02710110cfc4d5af 255 PANTHER PTHR10108:SF890 3 237 5.8E-29 T 21-04-2016 SPH21_RS22325 b0d43a23e8f345da02710110cfc4d5af 255 SUPERFAMILY SSF53335 6 223 1.09E-30 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS22325 b0d43a23e8f345da02710110cfc4d5af 255 PANTHER PTHR10108 3 237 5.8E-29 T 21-04-2016 SPH21_RS22325 b0d43a23e8f345da02710110cfc4d5af 255 Gene3D G3DSA:1.10.150.290 184 237 3.0E-9 T 21-04-2016 IPR023149 Trans-aconitate 2-methyltransferase, C-terminal GO:0030798 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SPH21_RS22325 b0d43a23e8f345da02710110cfc4d5af 255 Gene3D G3DSA:3.40.50.150 3 178 1.4E-30 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS06785 63d519973b070b652395e3f8e0d38f74 495 SMART SM00028 403 436 130.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06785 63d519973b070b652395e3f8e0d38f74 495 SMART SM00028 442 475 0.024 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS06785 63d519973b070b652395e3f8e0d38f74 495 Gene3D G3DSA:1.25.40.10 380 484 5.7E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06785 63d519973b070b652395e3f8e0d38f74 495 SUPERFAMILY SSF48452 357 477 1.2E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21775 68ee991201c85c8d52fcef147423636c 120 Pfam PF11512 Agrobacterium tumefaciens protein Atu4866 39 113 1.2E-36 T 21-04-2016 IPR020955 Uncharacterised protein family Atu4866 SPH21_RS11335 f0ddaa31721d52ce2c663546b25baa9c 313 SUPERFAMILY SSF51569 6 297 1.26E-46 T 21-04-2016 SPH21_RS11335 f0ddaa31721d52ce2c663546b25baa9c 313 Pfam PF00701 Dihydrodipicolinate synthetase family 6 292 1.6E-27 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS11335 f0ddaa31721d52ce2c663546b25baa9c 313 Gene3D G3DSA:3.20.20.70 2 304 4.8E-50 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS11335 f0ddaa31721d52ce2c663546b25baa9c 313 SMART SM01130 4 298 1.1E-28 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS11335 f0ddaa31721d52ce2c663546b25baa9c 313 PANTHER PTHR12128 1 312 1.2E-36 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS11335 f0ddaa31721d52ce2c663546b25baa9c 313 PIRSF PIRSF001365 1 301 1.0E-42 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS04800 5a4a7da277e40b55ce48e8d7ef4dbf60 168 Pfam PF07494 Two component regulator propeller 47 69 2.5E-6 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS04800 5a4a7da277e40b55ce48e8d7ef4dbf60 168 Pfam PF07494 Two component regulator propeller 92 114 0.009 T 21-04-2016 IPR011110 Two component regulator propeller SPH21_RS07270 ed1c8490fada8b70b41bd3871acb126f 283 PANTHER PTHR22936 24 211 3.0E-18 T 21-04-2016 IPR002610 Peptidase S54, rhomboid GO:0004252|GO:0006508|GO:0016021 SPH21_RS07270 ed1c8490fada8b70b41bd3871acb126f 283 SUPERFAMILY SSF144091 18 216 2.62E-29 T 21-04-2016 SPH21_RS07270 ed1c8490fada8b70b41bd3871acb126f 283 Pfam PF01694 Rhomboid family 68 215 4.1E-20 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS07270 ed1c8490fada8b70b41bd3871acb126f 283 Gene3D G3DSA:1.20.1540.10 20 214 2.9E-25 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 SUPERFAMILY SSF47203 241 390 1.29E-24 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 Gene3D G3DSA:1.20.140.10 230 398 3.6E-30 T 21-04-2016 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 44 122 1.1E-5 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 PANTHER PTHR10909 1 410 6.2E-44 T 21-04-2016 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 SUPERFAMILY SSF56645 39 237 2.62E-29 T 21-04-2016 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 Gene3D G3DSA:2.40.110.10 129 229 6.7E-14 T 21-04-2016 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 240 390 9.5E-24 T 21-04-2016 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 129 219 1.1E-11 T 21-04-2016 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 PANTHER PTHR10909:SF145 1 410 6.2E-44 T 21-04-2016 SPH21_RS04050 ed34dd3c8e6fc199afcccceed4791dfd 505 Gene3D G3DSA:1.10.540.10 42 124 3.2E-7 T 21-04-2016 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 Gene3D G3DSA:1.25.40.10 211 334 3.7E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 Gene3D G3DSA:1.25.40.10 135 168 3.7E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SMART SM00028 362 395 15.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SMART SM00028 572 606 190.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SMART SM00028 324 357 0.91 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SMART SM00028 211 244 240.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SMART SM00028 248 281 2.1 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 Gene3D G3DSA:1.25.40.10 335 386 3.4E-17 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 Gene3D G3DSA:1.25.40.10 555 643 3.4E-17 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SUPERFAMILY SSF48452 324 387 3.03E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SUPERFAMILY SSF48452 207 281 3.03E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 SUPERFAMILY SSF48452 135 163 3.03E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25790 bbdcb75eb58ffdf0a1c27fe099953461 965 Pfam PF13174 Tetratricopeptide repeat 573 605 0.0049 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031:SF122 572 598 6.9E-55 T 21-04-2016 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031:SF122 790 804 6.9E-55 T 21-04-2016 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031:SF122 18 214 6.9E-55 T 21-04-2016 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 Gene3D G3DSA:3.40.50.300 246 351 2.8E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 SUPERFAMILY SSF52540 23 360 2.63E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PIRSF PIRSF037307 1 803 1.2E-160 T 21-04-2016 IPR017170 Lhr-like ATP-dependent RNA helicase, predicted GO:0005524|GO:0016818 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031 790 804 6.9E-55 T 21-04-2016 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 SMART SM00487 10 217 2.3E-26 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 SMART SM00490 263 349 3.1E-10 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031:SF122 241 362 6.9E-55 T 21-04-2016 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 TIGRFAM TIGR04121 DEXH_lig_assoc: DEXH box helicase, DNA ligase-associated 4 803 0.0 T 21-04-2016 IPR026362 DEXH box helicase, DNA ligase-associated SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 Pfam PF00270 DEAD/DEAH box helicase 17 189 1.6E-26 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 Pfam PF00271 Helicase conserved C-terminal domain 243 345 5.1E-13 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 Gene3D G3DSA:3.40.50.300 3 194 1.9E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031 572 598 6.9E-55 T 21-04-2016 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031 241 362 6.9E-55 T 21-04-2016 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 Pfam PF08494 DEAD/H associated 589 775 1.5E-48 T 21-04-2016 IPR013701 DEAD/H associated GO:0005524|GO:0016818 SPH21_RS05455 57000921786c332a26a8dadc63eb9b63 804 PANTHER PTHR24031 18 214 6.9E-55 T 21-04-2016 SPH21_RS19830 dc8896dadb0bd6d43340cc98f333f240 378 SUPERFAMILY SSF53383 3 374 1.58E-90 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS19830 dc8896dadb0bd6d43340cc98f333f240 378 Gene3D G3DSA:3.40.640.10 15 246 5.3E-75 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS19830 dc8896dadb0bd6d43340cc98f333f240 378 PANTHER PTHR11601 2 373 1.4E-135 T 21-04-2016 SPH21_RS19830 dc8896dadb0bd6d43340cc98f333f240 378 PANTHER PTHR11601:SF20 2 373 1.4E-135 T 21-04-2016 SPH21_RS19830 dc8896dadb0bd6d43340cc98f333f240 378 PIRSF PIRSF005572 1 378 2.0E-113 T 21-04-2016 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 SPH21_RS19830 dc8896dadb0bd6d43340cc98f333f240 378 Pfam PF00266 Aminotransferase class-V 3 364 3.8E-71 T 21-04-2016 IPR000192 Aminotransferase class V domain SPH21_RS19830 dc8896dadb0bd6d43340cc98f333f240 378 Gene3D G3DSA:3.90.1150.10 247 373 1.3E-34 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS23225 2707774f31a110246788c9de3eb59860 659 Gene3D G3DSA:1.50.10.10 109 305 3.3E-17 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS23225 2707774f31a110246788c9de3eb59860 659 PANTHER PTHR31151 1 484 2.7E-225 T 21-04-2016 SPH21_RS23225 2707774f31a110246788c9de3eb59860 659 PANTHER PTHR31151 502 649 2.7E-225 T 21-04-2016 SPH21_RS23225 2707774f31a110246788c9de3eb59860 659 PANTHER PTHR31151:SF1 1 484 2.7E-225 T 21-04-2016 SPH21_RS23225 2707774f31a110246788c9de3eb59860 659 PANTHER PTHR31151:SF1 502 649 2.7E-225 T 21-04-2016 SPH21_RS23225 2707774f31a110246788c9de3eb59860 659 SUPERFAMILY SSF48208 93 394 9.64E-32 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS23225 2707774f31a110246788c9de3eb59860 659 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 36 566 2.4E-166 T 21-04-2016 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS19145 84065f2dfa3b6ad9838041f4976cc8f1 758 Pfam PF00999 Sodium/hydrogen exchanger family 71 461 6.0E-60 T 21-04-2016 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SPH21_RS19145 84065f2dfa3b6ad9838041f4976cc8f1 758 PANTHER PTHR32468 605 720 1.3E-191 T 21-04-2016 SPH21_RS19145 84065f2dfa3b6ad9838041f4976cc8f1 758 PANTHER PTHR32468 26 587 1.3E-191 T 21-04-2016 SPH21_RS19145 84065f2dfa3b6ad9838041f4976cc8f1 758 PANTHER PTHR32468:SF0 605 720 1.3E-191 T 21-04-2016 SPH21_RS19145 84065f2dfa3b6ad9838041f4976cc8f1 758 PANTHER PTHR32468:SF0 26 587 1.3E-191 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 Pfam PF04324 BFD-like [2Fe-2S] binding domain 420 468 7.0E-13 T 21-04-2016 IPR007419 BFD-like [2Fe-2S]-binding domain SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 SUPERFAMILY SSF56014 628 796 1.18E-45 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 99 117 5.4E-20 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 144 162 5.4E-20 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 256 278 5.4E-20 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 229 245 5.4E-20 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 3 22 5.4E-20 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 555 617 1.2E-12 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 SUPERFAMILY SSF51905 2 133 1.36E-17 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 Gene3D G3DSA:3.50.50.60 1 102 4.3E-24 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 271 278 1.8E-11 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 397 412 1.8E-11 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 230 244 1.8E-11 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 144 169 1.8E-11 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 2 24 1.8E-11 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 Gene3D G3DSA:3.50.50.60 103 304 4.0E-49 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PIRSF PIRSF037149 1 829 0.0 T 21-04-2016 IPR017121 Nitrite reductase [NAD(P)H], large subunit GO:0042128 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PANTHER PTHR11493:SF52 415 829 6.9E-263 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PANTHER PTHR11493:SF52 1 251 6.9E-263 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 2 282 4.5E-53 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 SUPERFAMILY SSF55124 492 636 7.03E-28 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 TIGRFAM TIGR02374 nitri_red_nirB: nitrite reductase [NAD(P)H], large subunit 3 795 0.0 T 21-04-2016 IPR012744 Nitrite reductase [NAD(P)H] large subunit, NirB GO:0008942|GO:0042128|GO:0050660|GO:0050661|GO:0055114 UniPathway: UPA00653 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 627 751 2.6E-17 T 21-04-2016 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 Gene3D G3DSA:3.30.413.10 627 752 6.3E-32 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PANTHER PTHR11493 415 829 6.9E-263 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PANTHER PTHR11493 1 251 6.9E-263 T 21-04-2016 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 SUPERFAMILY SSF51905 101 305 4.66E-39 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00397 Sirohaem Fe-binding site signature 674 692 2.1E-6 T 21-04-2016 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 PRINTS PR00397 Sirohaem Fe-binding site signature 631 649 2.1E-6 T 21-04-2016 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS18665 c5667f71377c5731b0f6c967fdb8d87c 833 ProSitePatterns PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 674 690 - T 21-04-2016 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 Pfam PF00216 Bacterial DNA-binding protein 1 90 6.0E-26 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 SUPERFAMILY SSF47729 1 91 1.28E-24 T 21-04-2016 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 PANTHER PTHR33175 1 94 1.7E-27 T 21-04-2016 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 Gene3D G3DSA:4.10.520.10 1 91 7.0E-27 T 21-04-2016 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 PRINTS PR01727 Prokaryotic integration host factor signature 58 71 3.6E-6 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 PRINTS PR01727 Prokaryotic integration host factor signature 40 55 3.6E-6 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 PRINTS PR01727 Prokaryotic integration host factor signature 74 88 3.6E-6 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS05550 ae585cc2e58d53b02f3b0b9248ad579d 94 SMART SM00411 1 90 1.9E-22 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 170 9.1E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 6 23 9.1E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 9.1E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 9.1E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 189 9.1E-23 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 1.7E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 1.7E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 170 1.7E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 Pfam PF00106 short chain dehydrogenase 5 188 2.9E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PANTHER PTHR24322:SF414 151 183 2.0E-51 T 21-04-2016 SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PANTHER PTHR24322:SF414 9 134 2.0E-51 T 21-04-2016 SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 SUPERFAMILY SSF51735 4 241 1.66E-60 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 Gene3D G3DSA:3.40.50.720 4 241 2.0E-62 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 138 166 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PANTHER PTHR24322 151 183 2.0E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04520 6744eb736e05655e2c49753c3d8c4247 281 PANTHER PTHR24322 9 134 2.0E-51 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 PANTHER PTHR11019 29 280 1.4E-30 T 21-04-2016 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 Pfam PF12833 Helix-turn-helix domain 205 282 1.8E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 Gene3D G3DSA:2.60.120.10 21 77 3.0E-9 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 SUPERFAMILY SSF51182 21 76 6.23E-10 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 SUPERFAMILY SSF46689 182 232 1.05E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 Gene3D G3DSA:1.10.10.60 179 234 8.0E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 SUPERFAMILY SSF46689 234 282 7.77E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 235 277 - T 21-04-2016 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 Pfam PF02311 AraC-like ligand binding domain 29 109 1.1E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 SMART SM00342 198 281 4.4E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 Gene3D G3DSA:1.10.10.60 235 280 9.5E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS19075 52f8f8931d367dfabafcd529c89247c3 287 PANTHER PTHR11019:SF65 29 280 1.4E-30 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 PANTHER PTHR11532 444 771 1.2E-206 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 PANTHER PTHR11532 788 1002 1.2E-206 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 PANTHER PTHR11532 20 358 1.2E-206 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 PANTHER PTHR11532:SF57 444 771 1.2E-206 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 PANTHER PTHR11532:SF57 788 1002 1.2E-206 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 PANTHER PTHR11532:SF57 20 358 1.2E-206 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Pfam PF00593 TonB dependent receptor 593 1002 2.4E-15 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 SUPERFAMILY SSF49464 37 118 4.84E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Gene3D G3DSA:2.60.40.1120 38 127 6.9E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Gene3D G3DSA:2.40.170.20 848 1004 2.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Gene3D G3DSA:2.40.170.20 279 763 2.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Gene3D G3DSA:2.40.170.20 238 245 2.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Gene3D G3DSA:2.40.170.20 811 812 2.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Pfam PF07715 TonB-dependent Receptor Plug Domain 130 234 1.1E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 210 240 6.8E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Pfam PF13715 CarboxypepD_reg-like domain 39 120 8.2E-18 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 SUPERFAMILY SSF56935 839 1004 2.15E-79 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 SUPERFAMILY SSF56935 116 258 2.15E-79 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 SUPERFAMILY SSF56935 296 763 2.15E-79 T 21-04-2016 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 37 1004 8.7E-216 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS10130 e820a6ada29723747285da786d92af5e 1004 Gene3D G3DSA:2.170.130.10 130 237 1.2E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12280 4619fbc22e568d932349a5645f176d56 296 PANTHER PTHR10366:SF262 5 296 1.4E-57 T 21-04-2016 SPH21_RS12280 4619fbc22e568d932349a5645f176d56 296 Gene3D G3DSA:3.40.50.720 4 290 4.9E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12280 4619fbc22e568d932349a5645f176d56 296 SUPERFAMILY SSF51735 1 290 1.69E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12280 4619fbc22e568d932349a5645f176d56 296 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 217 3.5E-15 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS12280 4619fbc22e568d932349a5645f176d56 296 PANTHER PTHR10366 5 296 1.4E-57 T 21-04-2016 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 TIGRFAM TIGR00445 mraY: phospho-N-acetylmuramoyl-pentapeptide-transferase 222 414 1.5E-73 T 21-04-2016 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 ProSitePatterns PS01348 MraY family signature 2. 237 248 - T 21-04-2016 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 Hamap MF_00038 Phospho-N-acetylmuramoyl-pentapeptide-transferase [mraY]. 27 412 21.508 T 21-04-2016 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 Pfam PF10555 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 70 82 3.2E-5 T 21-04-2016 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 PANTHER PTHR22926 2 154 3.4E-127 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 PANTHER PTHR22926 222 414 3.4E-127 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 PANTHER PTHR22926 186 206 3.4E-127 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 Pfam PF00953 Glycosyl transferase family 4 101 332 1.7E-39 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 PANTHER PTHR22926:SF5 2 154 3.4E-127 T 21-04-2016 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 PANTHER PTHR22926:SF5 222 414 3.4E-127 T 21-04-2016 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 PANTHER PTHR22926:SF5 186 206 3.4E-127 T 21-04-2016 SPH21_RS00290 2759e64ca492585deee0fea3a08ca55d 414 ProSitePatterns PS01347 MraY family signature 1. 70 82 - T 21-04-2016 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 PANTHER PTHR18895:SF73 30 231 2.9E-40 T 21-04-2016 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 SUPERFAMILY SSF53335 31 220 4.11E-25 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 Pfam PF05175 Methyltransferase small domain 30 162 3.5E-17 T 21-04-2016 IPR007848 Methyltransferase small domain GO:0008168 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 112 118 - T 21-04-2016 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 PANTHER PTHR18895 30 231 2.9E-40 T 21-04-2016 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 109 121 2.8E-6 T 21-04-2016 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 44 58 2.8E-6 T 21-04-2016 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 139 163 2.8E-6 T 21-04-2016 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 Hamap MF_01872 tRNA1(Val) (adenine(37)-N6)-methyltransferase [yfiC]. 7 241 48.938 T 21-04-2016 IPR022882 tRNA1(Val) (adenine(37)-N6)-methyltransferase GO:0016430 KEGG: 00340+2.1.1.22 SPH21_RS18125 a6b1c98d77b5a4085a187565c24478d3 241 Gene3D G3DSA:3.40.50.150 28 234 2.5E-38 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 SUPERFAMILY SSF51735 2 306 4.33E-70 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 Gene3D G3DSA:3.40.50.720 5 208 2.0E-70 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 PANTHER PTHR10366:SF246 6 305 1.9E-144 T 21-04-2016 SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 PANTHER PTHR10366 6 305 1.9E-144 T 21-04-2016 SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 Gene3D G3DSA:3.90.25.10 285 306 5.8E-6 T 21-04-2016 SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 Gene3D G3DSA:3.90.25.10 209 232 5.8E-6 T 21-04-2016 SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 Pfam PF01370 NAD dependent epimerase/dehydratase family 7 238 8.9E-76 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS09935 c23183934c9accb970a0ae336339e900 313 Hamap MF_00956 GDP-L-fucose synthase [fcl]. 4 306 50.062 T 21-04-2016 IPR028614 GDP-L-fucose synthase/GDP-L-colitose synthase GO:0009226|GO:0016491 KEGG: 00010+1.1.1.27|KEGG: 00051+1.1.1.271|KEGG: 00270+1.1.1.27|KEGG: 00520+1.1.1.271|KEGG: 00620+1.1.1.27|KEGG: 00640+1.1.1.27|MetaCyc: PWY-5481|MetaCyc: PWY-66|MetaCyc: PWY-6901|UniPathway: UPA00128 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 Gene3D G3DSA:1.10.10.60 335 384 7.5E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 PANTHER PTHR30146:SF24 48 317 3.8E-57 T 21-04-2016 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 PANTHER PTHR30146 48 317 3.8E-57 T 21-04-2016 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 Gene3D G3DSA:1.10.10.60 283 334 4.7E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 Pfam PF13377 Periplasmic binding protein-like domain 110 274 3.1E-31 T 21-04-2016 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 Gene3D G3DSA:3.40.50.2300 110 274 6.1E-27 T 21-04-2016 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 Gene3D G3DSA:3.40.50.2300 7 109 2.4E-7 T 21-04-2016 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 SUPERFAMILY SSF46689 334 384 4.21E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 SMART SM00342 298 381 1.9E-12 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 SUPERFAMILY SSF53822 6 274 1.18E-33 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS09435 af5858ca7c6f283bfef797c6464c69f7 388 Pfam PF12833 Helix-turn-helix domain 310 383 2.7E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS15770 abe3530e4604251b04d0df41e32bf2ad 343 SUPERFAMILY SSF51735 7 191 1.41E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15770 abe3530e4604251b04d0df41e32bf2ad 343 Gene3D G3DSA:3.30.360.10 134 338 1.8E-29 T 21-04-2016 SPH21_RS15770 abe3530e4604251b04d0df41e32bf2ad 343 PANTHER PTHR22604 5 337 2.3E-88 T 21-04-2016 SPH21_RS15770 abe3530e4604251b04d0df41e32bf2ad 343 PANTHER PTHR22604:SF53 5 337 2.3E-88 T 21-04-2016 SPH21_RS15770 abe3530e4604251b04d0df41e32bf2ad 343 Gene3D G3DSA:3.40.50.720 5 133 4.3E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15770 abe3530e4604251b04d0df41e32bf2ad 343 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 13 121 2.5E-23 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS15770 abe3530e4604251b04d0df41e32bf2ad 343 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 135 223 1.8E-10 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS08385 ffa506717e46586930e0c40c0fbbd701 103 PANTHER PTHR40077 5 102 1.7E-19 T 21-04-2016 SPH21_RS08385 ffa506717e46586930e0c40c0fbbd701 103 Pfam PF12823 Domain of unknown function (DUF3817) 13 99 8.8E-26 T 21-04-2016 IPR023845 Domain of unknown function DUF3817, transmembrane SPH21_RS08385 ffa506717e46586930e0c40c0fbbd701 103 TIGRFAM TIGR03954 integ_memb_HG: integral membrane protein 15 98 3.2E-31 T 21-04-2016 IPR023845 Domain of unknown function DUF3817, transmembrane SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 Gene3D G3DSA:2.40.50.40 154 219 6.1E-11 T 21-04-2016 SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 Gene3D G3DSA:3.40.50.2300 17 135 5.4E-22 T 21-04-2016 SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 Pfam PF00072 Response regulator receiver domain 22 128 8.8E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 Pfam PF04397 LytTr DNA-binding domain 161 252 2.9E-15 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 PANTHER PTHR26402 19 127 4.3E-22 T 21-04-2016 SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 SMART SM00448 19 129 2.2E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 SMART SM00850 157 253 3.0E-17 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS09185 8c2640675fe8542d5e72b2dd137efdf8 258 SUPERFAMILY SSF52172 19 134 3.84E-23 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23015 22a432e24029b9a8861b09b4ccf6d292 124 SUPERFAMILY SSF158446 7 112 1.7E-26 T 21-04-2016 SPH21_RS23015 22a432e24029b9a8861b09b4ccf6d292 124 Gene3D G3DSA:1.20.1440.60 7 117 6.0E-31 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS23015 22a432e24029b9a8861b09b4ccf6d292 124 PANTHER PTHR38471 3 123 4.7E-24 T 21-04-2016 SPH21_RS23015 22a432e24029b9a8861b09b4ccf6d292 124 Pfam PF05635 23S rRNA-intervening sequence protein 7 109 2.7E-21 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS23015 22a432e24029b9a8861b09b4ccf6d292 124 TIGRFAM TIGR02436 TIGR02436: four helix bundle protein 13 115 3.4E-26 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS23015 22a432e24029b9a8861b09b4ccf6d292 124 PIRSF PIRSF035652 5 121 2.5E-33 T 21-04-2016 IPR012657 23S rRNA-intervening sequence protein SPH21_RS23015 22a432e24029b9a8861b09b4ccf6d292 124 PANTHER PTHR38471:SF1 3 123 4.7E-24 T 21-04-2016 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 Gene3D G3DSA:1.10.150.170 108 210 1.5E-29 T 21-04-2016 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 SUPERFAMILY SSF53335 208 301 2.57E-48 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 SUPERFAMILY SSF53335 5 109 2.57E-48 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 PANTHER PTHR11265:SF0 1 303 3.1E-123 T 21-04-2016 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 PIRSF PIRSF004486 1 302 4.3E-102 T 21-04-2016 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 PANTHER PTHR11265 1 303 3.1E-123 T 21-04-2016 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 TIGRFAM TIGR00006 TIGR00006: 16S rRNA (cytosine(1402)-N(4))-methyltransferase 2 300 1.0E-98 T 21-04-2016 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 SUPERFAMILY SSF81799 110 208 3.79E-28 T 21-04-2016 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 Pfam PF01795 MraW methylase family 5 300 2.5E-97 T 21-04-2016 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 Hamap MF_01007 Ribosomal RNA small subunit methyltransferase H [rsmH]. 6 301 35.717 T 21-04-2016 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 Gene3D G3DSA:3.40.50.150 211 302 4.1E-55 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS00310 da1ae278ca81cf4714e979a46ee7665c 303 Gene3D G3DSA:3.40.50.150 6 106 4.1E-55 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS08905 f09be78273d75730809f48f935d99fe4 296 SUPERFAMILY SSF53448 1 218 1.13E-49 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08905 f09be78273d75730809f48f935d99fe4 296 Pfam PF00535 Glycosyl transferase family 2 3 133 3.3E-33 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS08905 f09be78273d75730809f48f935d99fe4 296 PANTHER PTHR22916 1 227 1.2E-39 T 21-04-2016 SPH21_RS08905 f09be78273d75730809f48f935d99fe4 296 Gene3D G3DSA:3.90.550.10 2 220 9.2E-47 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Gene3D G3DSA:3.40.228.10 168 350 6.2E-57 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 SUPERFAMILY SSF53706 31 611 3.27E-174 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Pfam PF01568 Molydopterin dinucleotide binding domain 610 716 7.2E-29 T 21-04-2016 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 SUPERFAMILY SSF50692 581 720 7.23E-43 T 21-04-2016 IPR009010 Aspartate decarboxylase-like domain SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Gene3D G3DSA:3.40.50.740 93 167 2.6E-73 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Gene3D G3DSA:3.40.50.740 351 591 2.6E-73 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Gene3D G3DSA:2.40.40.20 601 721 1.0E-40 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 PANTHER PTHR11615:SF119 33 739 2.2E-163 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Gene3D G3DSA:2.20.25.90 35 92 1.4E-17 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 SMART SM00926 34 87 8.3E-13 T 21-04-2016 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Pfam PF00384 Molybdopterin oxidoreductase 91 516 9.0E-66 T 21-04-2016 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 PANTHER PTHR11615 33 739 2.2E-163 T 21-04-2016 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 36 80 4.4E-13 T 21-04-2016 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 SPH21_RS13360 0aa48efaeb7c9f30624847baf5085557 739 ProSitePatterns PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 39 57 - T 21-04-2016 IPR027467 Molybdopterin oxidoreductase, molybdopterin cofactor binding site GO:0051539 KEGG: 00910+1.7.99.4 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 252 384 6.8E-43 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 TIGRFAM TIGR01241 FtsH_fam: ATP-dependent metallopeptidase HflB 159 648 1.2E-222 T 21-04-2016 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 SUPERFAMILY SSF52540 209 456 4.95E-67 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 Gene3D G3DSA:1.10.8.60 394 459 1.0E-26 T 21-04-2016 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 SUPERFAMILY SSF140990 466 654 2.75E-67 T 21-04-2016 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 Hamap MF_01458 ATP-dependent zinc metalloprotease FtsH [ftsH]. 11 656 35.615 T 21-04-2016 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 SMART SM00382 247 387 2.0E-22 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 ProSitePatterns PS00674 AAA-protein family signature. 355 373 - T 21-04-2016 IPR003960 ATPase, AAA-type, conserved site GO:0005524 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 Pfam PF06480 FtsH Extracellular 29 138 1.4E-7 T 21-04-2016 IPR011546 Peptidase M41, FtsH extracellular GO:0004222|GO:0005524|GO:0008270|GO:0016021 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 Gene3D G3DSA:3.40.50.300 211 393 2.6E-61 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 Pfam PF01434 Peptidase family M41 446 647 1.0E-76 T 21-04-2016 IPR000642 Peptidase M41 GO:0004222|GO:0005524|GO:0006508 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 PANTHER PTHR23076 28 687 0.0 T 21-04-2016 SPH21_RS05190 d4abde132b145d360cffc325442d1c09 707 PANTHER PTHR23076:SF10 28 687 0.0 T 21-04-2016 SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 SUPERFAMILY SSF89550 134 258 1.18E-7 T 21-04-2016 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 SUPERFAMILY SSF89550 8 97 1.18E-7 T 21-04-2016 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 Pfam PF13476 AAA domain 301 476 4.2E-6 T 21-04-2016 SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 Gene3D G3DSA:3.40.1140.10 302 393 5.8E-18 T 21-04-2016 SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 Gene3D G3DSA:3.40.1140.10 761 830 5.8E-18 T 21-04-2016 SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 SUPERFAMILY SSF52540 749 835 1.95E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 SUPERFAMILY SSF52540 411 511 3.08E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 SMART SM00382 307 841 2.2E-6 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 SUPERFAMILY SSF52540 306 405 1.95E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system 586 823 5.6E-10 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 SUPERFAMILY SSF52540 308 357 3.08E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17805 49aa06d915aae4bda7c4affc4d0a845b 883 Gene3D G3DSA:3.40.50.300 538 618 3.9E-4 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 Pfam PF02779 Transketolase, pyrimidine binding domain 3 177 1.5E-48 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 SUPERFAMILY SSF52518 2 203 8.57E-67 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 PANTHER PTHR11624:SF11 1 325 5.8E-159 T 21-04-2016 SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 SUPERFAMILY SSF52922 187 323 6.54E-37 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 Gene3D G3DSA:3.40.50.970 1 193 5.7E-90 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 SMART SM00861 4 179 2.8E-58 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 Gene3D G3DSA:3.40.50.920 194 323 1.5E-39 T 21-04-2016 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 PANTHER PTHR11624 1 325 5.8E-159 T 21-04-2016 IPR033247 Transketolase family SPH21_RS06445 f15aec4cbfde6d5245731041fc7cfbc5 327 Pfam PF02780 Transketolase, C-terminal domain 193 316 1.9E-33 T 21-04-2016 IPR033248 Transketolase, C-terminal domain SPH21_RS15750 1893df6778cfe421b1acab228a6cff35 205 Pfam PF08889 WbqC-like protein family 166 202 1.0E-4 T 21-04-2016 IPR014985 WbqC-like protein family SPH21_RS15750 1893df6778cfe421b1acab228a6cff35 205 Pfam PF08889 WbqC-like protein family 28 147 1.8E-24 T 21-04-2016 IPR014985 WbqC-like protein family SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 PANTHER PTHR30173:SF20 24 218 3.5E-35 T 21-04-2016 SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 Pfam PF08281 Sigma-70, region 4 150 193 6.8E-8 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 Gene3D G3DSA:1.10.10.10 146 208 2.8E-9 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 PANTHER PTHR30173 24 218 3.5E-35 T 21-04-2016 SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 Gene3D G3DSA:1.10.1740.10 44 127 4.3E-18 T 21-04-2016 SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 SUPERFAMILY SSF88946 44 124 1.92E-17 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 49 205 3.6E-24 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 Pfam PF04542 Sigma-70 region 2 53 119 1.7E-13 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS04900 e2a41d8b407841ca9c4d3091c5d9820f 228 SUPERFAMILY SSF88659 147 218 1.42E-10 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 SUPERFAMILY SSF51556 54 372 1.95E-88 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 Gene3D G3DSA:2.30.40.10 4 68 7.7E-18 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 ProSitePatterns PS00483 Dihydroorotase signature 2. 307 318 - T 21-04-2016 IPR002195 Dihydroorotase, conserved site GO:0016812 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 PANTHER PTHR11647 1 440 1.4E-128 T 21-04-2016 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 PANTHER PTHR11647:SF1 1 440 1.4E-128 T 21-04-2016 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 Pfam PF01979 Amidohydrolase family 51 424 3.8E-15 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 SUPERFAMILY SSF51338 1 53 3.88E-29 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 SUPERFAMILY SSF51338 371 435 3.88E-29 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS19295 51ce588e4c343f5acd4c3ae47c6849bf 445 Gene3D G3DSA:3.20.20.140 69 411 1.1E-96 T 21-04-2016 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 Gene3D G3DSA:1.10.10.10 5 72 4.3E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 PANTHER PTHR11751 116 131 6.8E-14 T 21-04-2016 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 PANTHER PTHR11751 21 78 6.8E-14 T 21-04-2016 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 Pfam PF07702 UTRA domain 99 234 2.2E-29 T 21-04-2016 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 SUPERFAMILY SSF64288 65 242 6.12E-40 T 21-04-2016 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 SMART SM00345 17 76 4.2E-10 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 SMART SM00866 97 235 1.1E-21 T 21-04-2016 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 Pfam PF00392 Bacterial regulatory proteins, gntR family 17 76 1.4E-14 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 36 50 4.4E-6 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 66 4.4E-6 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 Gene3D G3DSA:3.40.1410.10 73 241 4.2E-43 T 21-04-2016 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SPH21_RS21030 16df26d0aacb5638cda686e16d6e7134 243 SUPERFAMILY SSF46785 6 80 3.06E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PANTHER PTHR30330:SF7 1 478 1.8E-281 T 21-04-2016 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PRINTS PR00175 Sodium/alanine symporter signature 295 313 4.3E-58 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PRINTS PR00175 Sodium/alanine symporter signature 204 223 4.3E-58 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PRINTS PR00175 Sodium/alanine symporter signature 86 108 4.3E-58 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PRINTS PR00175 Sodium/alanine symporter signature 353 375 4.3E-58 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PRINTS PR00175 Sodium/alanine symporter signature 176 194 4.3E-58 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PRINTS PR00175 Sodium/alanine symporter signature 416 436 4.3E-58 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 TIGRFAM TIGR00835 agcS: amino acid carrier protein 13 447 2.0E-149 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 PANTHER PTHR30330 1 478 1.8E-281 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS01005 036156d815c15bc86b2213cd15e7d651 482 Pfam PF01235 Sodium:alanine symporter family 50 459 1.0E-163 T 21-04-2016 IPR001463 Sodium:alanine symporter GO:0006814|GO:0015655|GO:0016020|GO:0032328 SPH21_RS15595 7172a18b61d4b6358edd86e120672d2f 527 SUPERFAMILY SSF48452 21 527 3.51E-91 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS15595 7172a18b61d4b6358edd86e120672d2f 527 PANTHER PTHR35148 2 527 1.9E-29 T 21-04-2016 SPH21_RS15595 7172a18b61d4b6358edd86e120672d2f 527 Pfam PF12771 Starch-binding associating with outer membrane 104 524 6.5E-32 T 21-04-2016 SPH21_RS25165 16230426c2ea3aeadcc0f90d998a16fe 237 SUPERFAMILY SSF51197 18 196 4.74E-7 T 21-04-2016 SPH21_RS25165 16230426c2ea3aeadcc0f90d998a16fe 237 Pfam PF09859 Oxygenase, catalysing oxidative methylation of damaged DNA 64 235 2.8E-78 T 21-04-2016 IPR018655 Protein of unknown function DUF2086 SPH21_RS09660 f0ce91e6c8f407d36766e9eb053b9406 420 Pfam PF13579 Glycosyl transferase 4-like domain 15 203 2.4E-20 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS09660 f0ce91e6c8f407d36766e9eb053b9406 420 PANTHER PTHR12526:SF320 1 417 2.9E-46 T 21-04-2016 SPH21_RS09660 f0ce91e6c8f407d36766e9eb053b9406 420 PANTHER PTHR12526 1 417 2.9E-46 T 21-04-2016 SPH21_RS09660 f0ce91e6c8f407d36766e9eb053b9406 420 SUPERFAMILY SSF53756 1 407 7.07E-50 T 21-04-2016 SPH21_RS09660 f0ce91e6c8f407d36766e9eb053b9406 420 Gene3D G3DSA:3.40.50.2000 193 308 1.0E-9 T 21-04-2016 SPH21_RS09660 f0ce91e6c8f407d36766e9eb053b9406 420 Pfam PF00534 Glycosyl transferases group 1 217 387 2.8E-19 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 Gene3D G3DSA:3.40.50.2300 2 121 2.0E-23 T 21-04-2016 SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 SUPERFAMILY SSF52172 2 125 4.98E-23 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 Gene3D G3DSA:2.40.50.40 139 210 7.2E-23 T 21-04-2016 SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 Pfam PF00072 Response regulator receiver domain 7 116 6.2E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 PANTHER PTHR26402 3 115 1.0E-27 T 21-04-2016 SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 Pfam PF04397 LytTr DNA-binding domain 149 240 8.1E-19 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 SMART SM00850 148 241 2.6E-25 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS17025 8bf987a7320c7879dd3690e18608a1a9 244 SMART SM00448 3 116 2.6E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 Hamap MF_02121 Aspartate-semialdehyde dehydrogenase [asd]. 1 324 34.945 T 21-04-2016 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 Gene3D G3DSA:3.40.50.720 1 138 2.2E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 135 310 7.4E-51 T 21-04-2016 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 SMART SM00859 2 117 2.3E-35 T 21-04-2016 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 PANTHER PTHR10174:SF2 57 326 1.7E-76 T 21-04-2016 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 TIGRFAM TIGR01296 asd_B: aspartate-semialdehyde dehydrogenase 2 325 4.4E-134 T 21-04-2016 IPR005986 Aspartate-semialdehyde dehydrogenase, beta-type GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 PANTHER PTHR10174 57 326 1.7E-76 T 21-04-2016 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 SUPERFAMILY SSF55347 125 311 6.82E-75 T 21-04-2016 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 2 115 3.8E-29 T 21-04-2016 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 Gene3D G3DSA:3.30.360.10 139 307 1.8E-77 T 21-04-2016 SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 SUPERFAMILY SSF51735 1 153 7.92E-49 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05280 44cb92975b145965e80d2c09935c81f7 329 PIRSF PIRSF000148 1 329 9.4E-125 T 21-04-2016 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153|UniPathway: UPA00034|UniPathway: UPA00050|UniPathway: UPA00051 SPH21_RS16050 4a28ef76f4f12bd6ee6c05569662ab50 348 Pfam PF07642 Putative beta-barrel porin-2, OmpL-like. bbp2 25 348 3.8E-74 T 21-04-2016 IPR011486 Putative beta-barrel porin-2, OmpL-like. bbp2 SPH21_RS16050 4a28ef76f4f12bd6ee6c05569662ab50 348 SUPERFAMILY SSF56935 13 285 1.71E-8 T 21-04-2016 SPH21_RS16050 4a28ef76f4f12bd6ee6c05569662ab50 348 Gene3D G3DSA:2.40.160.10 104 253 3.7E-6 T 21-04-2016 IPR023614 Porin domain SPH21_RS03655 2eae19f79515c7e6c4e981d38a8bbae3 321 SUPERFAMILY SSF51735 2 319 1.78E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03655 2eae19f79515c7e6c4e981d38a8bbae3 321 Gene3D G3DSA:3.40.50.720 2 317 9.0E-52 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03655 2eae19f79515c7e6c4e981d38a8bbae3 321 PANTHER PTHR10366 271 319 3.3E-57 T 21-04-2016 SPH21_RS03655 2eae19f79515c7e6c4e981d38a8bbae3 321 PANTHER PTHR10366 1 251 3.3E-57 T 21-04-2016 SPH21_RS03655 2eae19f79515c7e6c4e981d38a8bbae3 321 Pfam PF01370 NAD dependent epimerase/dehydratase family 2 221 1.4E-26 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS10395 c17a49a810b3db72b4935534a10a34b6 118 SMART SM00448 3 113 2.9E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10395 c17a49a810b3db72b4935534a10a34b6 118 PANTHER PTHR26402 3 117 1.0E-26 T 21-04-2016 SPH21_RS10395 c17a49a810b3db72b4935534a10a34b6 118 SUPERFAMILY SSF52172 2 117 7.54E-28 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10395 c17a49a810b3db72b4935534a10a34b6 118 Gene3D G3DSA:3.40.50.2300 2 117 8.3E-28 T 21-04-2016 SPH21_RS10395 c17a49a810b3db72b4935534a10a34b6 118 Pfam PF00072 Response regulator receiver domain 5 113 2.6E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS21740 fa78659247249cf202146eef7115458c 136 PANTHER PTHR34610 6 136 8.9E-18 T 21-04-2016 SPH21_RS21740 fa78659247249cf202146eef7115458c 136 SUPERFAMILY SSF88723 5 126 1.62E-13 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS21740 fa78659247249cf202146eef7115458c 136 PANTHER PTHR34610:SF3 6 136 8.9E-18 T 21-04-2016 SPH21_RS21740 fa78659247249cf202146eef7115458c 136 SMART SM00670 3 116 1.9E-4 T 21-04-2016 IPR002716 PIN domain SPH21_RS21740 fa78659247249cf202146eef7115458c 136 Pfam PF13470 PIN domain 6 112 3.6E-13 T 21-04-2016 IPR002716 PIN domain SPH21_RS21740 fa78659247249cf202146eef7115458c 136 TIGRFAM TIGR00305 TIGR00305: putative toxin-antitoxin system toxin component, PIN family 6 117 2.7E-19 T 21-04-2016 IPR002850 PIN family, putative toxin-antitoxin system toxin component SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 Pfam PF00849 RNA pseudouridylate synthase 107 263 1.1E-36 T 21-04-2016 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 PANTHER PTHR11079:SF73 9 348 5.4E-133 T 21-04-2016 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 Pfam PF01479 S4 domain 34 79 2.7E-10 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 SUPERFAMILY SSF55120 91 339 2.26E-75 T 21-04-2016 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 TIGRFAM TIGR00005 rluA_subfam: pseudouridine synthase, RluA family 33 337 3.4E-87 T 21-04-2016 IPR006225 Pseudouridine synthase, RluC/RluD GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 SMART SM00363 33 92 2.0E-9 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 154 168 - T 21-04-2016 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 PANTHER PTHR11079 9 348 5.4E-133 T 21-04-2016 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 Gene3D G3DSA:3.10.290.10 33 81 1.3E-14 T 21-04-2016 IPR002942 RNA-binding S4 domain GO:0003723 SPH21_RS17665 e877e09f0d823b3bd1f20dc81e130551 348 SUPERFAMILY SSF55174 33 120 2.69E-12 T 21-04-2016 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 Pfam PF03471 Transporter associated domain 351 427 1.0E-18 T 21-04-2016 IPR005170 Transporter-associated domain SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 Pfam PF01595 Domain of unknown function DUF21 7 198 1.5E-46 T 21-04-2016 IPR002550 Domain of unknown function DUF21 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 SUPERFAMILY SSF54631 211 351 6.95E-32 T 21-04-2016 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 SUPERFAMILY SSF56176 345 426 3.0E-19 T 21-04-2016 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 PANTHER PTHR22777 1 438 2.3E-160 T 21-04-2016 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 Gene3D G3DSA:3.10.580.10 202 343 2.7E-19 T 21-04-2016 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 Gene3D G3DSA:3.30.465.10 344 426 1.5E-22 T 21-04-2016 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 PANTHER PTHR22777:SF18 1 438 2.3E-160 T 21-04-2016 SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 Pfam PF00571 CBS domain 286 335 6.6E-4 T 21-04-2016 IPR000644 CBS domain SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 Pfam PF00571 CBS domain 222 270 2.4E-5 T 21-04-2016 IPR000644 CBS domain SPH21_RS07935 850edf8da5dd5e28e5c467acb6c37627 439 SMART SM01091 350 429 8.2E-20 T 21-04-2016 IPR005170 Transporter-associated domain SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 Gene3D G3DSA:2.170.130.10 119 230 5.4E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 Pfam PF13715 CarboxypepD_reg-like domain 23 106 4.3E-15 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 PANTHER PTHR11532 1 436 3.6E-110 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 PANTHER PTHR11532 556 1069 3.6E-110 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 PANTHER PTHR11532:SF57 1 436 3.6E-110 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 PANTHER PTHR11532:SF57 556 1069 3.6E-110 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 198 228 3.0E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 Pfam PF07715 TonB-dependent Receptor Plug Domain 119 222 2.2E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 22 1070 9.6E-145 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 SUPERFAMILY SSF56935 990 1067 1.37E-58 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 SUPERFAMILY SSF56935 106 247 1.37E-58 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 SUPERFAMILY SSF56935 900 946 1.37E-58 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 SUPERFAMILY SSF56935 327 416 1.37E-58 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 SUPERFAMILY SSF56935 466 836 1.37E-58 T 21-04-2016 SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 SUPERFAMILY SSF49464 21 105 7.72E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS00445 75b7b06a0eb76b2d8e00f981cc08f276 1071 Gene3D G3DSA:2.60.40.1120 22 94 1.8E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02970 97d1fdcfe140f2830a28a6765537d6b4 388 SUPERFAMILY SSF51445 52 373 1.67E-54 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS02970 97d1fdcfe140f2830a28a6765537d6b4 388 Gene3D G3DSA:3.20.20.80 52 365 1.1E-71 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS02970 97d1fdcfe140f2830a28a6765537d6b4 388 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 74 349 1.2E-8 T 21-04-2016 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SPH21_RS02385 c7cbcbc9c39ae2765001c56595463172 592 Gene3D G3DSA:2.60.120.260 82 201 1.4E-11 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02385 c7cbcbc9c39ae2765001c56595463172 592 PANTHER PTHR34987:SF1 509 587 2.2E-48 T 21-04-2016 SPH21_RS02385 c7cbcbc9c39ae2765001c56595463172 592 PANTHER PTHR34987:SF1 85 489 2.2E-48 T 21-04-2016 SPH21_RS02385 c7cbcbc9c39ae2765001c56595463172 592 SUPERFAMILY SSF48208 206 590 9.35E-36 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02385 c7cbcbc9c39ae2765001c56595463172 592 PANTHER PTHR34987 509 587 2.2E-48 T 21-04-2016 SPH21_RS02385 c7cbcbc9c39ae2765001c56595463172 592 PANTHER PTHR34987 85 489 2.2E-48 T 21-04-2016 SPH21_RS02385 c7cbcbc9c39ae2765001c56595463172 592 Pfam PF05592 Bacterial alpha-L-rhamnosidase 94 588 2.6E-36 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 SUPERFAMILY SSF51445 324 674 1.99E-63 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 PANTHER PTHR10066 64 426 1.5E-142 T 21-04-2016 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 PANTHER PTHR10066 447 870 1.5E-142 T 21-04-2016 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 SUPERFAMILY SSF49303 680 775 1.08E-15 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 371 480 1.3E-4 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 PANTHER PTHR10066:SF66 64 426 1.5E-142 T 21-04-2016 IPR028829 Exo-beta-D-glucosaminidase GO:0000272|GO:0005576|GO:0052761 KEGG: 00520+3.2.1.165 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 PANTHER PTHR10066:SF66 447 870 1.5E-142 T 21-04-2016 IPR028829 Exo-beta-D-glucosaminidase GO:0000272|GO:0005576|GO:0052761 KEGG: 00520+3.2.1.165 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 SUPERFAMILY SSF49303 212 327 3.45E-18 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 Gene3D G3DSA:2.60.40.320 213 326 5.3E-16 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 Pfam PF00703 Glycosyl hydrolases family 2 212 327 1.0E-15 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 SUPERFAMILY SSF49785 37 207 6.8E-34 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 SUPERFAMILY SSF49303 779 884 1.15E-22 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 Gene3D G3DSA:3.20.20.80 327 574 1.1E-31 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 Gene3D G3DSA:3.20.20.80 615 678 1.1E-31 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS09430 db68673a404d3cf319ec7d421eb3c0c0 890 Gene3D G3DSA:2.60.120.260 37 207 4.9E-22 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22195 6092a0e9e78530507532d417972730b9 489 Pfam PF06580 Histidine kinase 297 373 1.8E-20 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS22195 6092a0e9e78530507532d417972730b9 489 SUPERFAMILY SSF55874 361 460 4.26E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS22195 6092a0e9e78530507532d417972730b9 489 PANTHER PTHR34220:SF1 125 489 5.4E-45 T 21-04-2016 SPH21_RS22195 6092a0e9e78530507532d417972730b9 489 PANTHER PTHR34220 125 489 5.4E-45 T 21-04-2016 SPH21_RS21715 e02a99bd7c800761f86aaa8c8fe04382 189 PANTHER PTHR24567:SF33 10 189 6.5E-23 T 21-04-2016 SPH21_RS21715 e02a99bd7c800761f86aaa8c8fe04382 189 Pfam PF00027 Cyclic nucleotide-binding domain 30 113 2.5E-8 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS21715 e02a99bd7c800761f86aaa8c8fe04382 189 PANTHER PTHR24567 10 189 6.5E-23 T 21-04-2016 SPH21_RS21715 e02a99bd7c800761f86aaa8c8fe04382 189 Gene3D G3DSA:2.60.120.10 1 155 1.7E-30 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS21715 e02a99bd7c800761f86aaa8c8fe04382 189 SUPERFAMILY SSF51206 4 138 1.11E-17 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 SUPERFAMILY SSF55681 90 479 1.99E-93 T 21-04-2016 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 SUPERFAMILY SSF50249 3 97 1.57E-13 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 Gene3D G3DSA:3.30.930.10 102 478 7.2E-113 T 21-04-2016 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 Hamap MF_00534 Asparagine--tRNA ligase [asnS]. 6 481 44.613 T 21-04-2016 IPR004522 Asparagine-tRNA ligase GO:0000166|GO:0004816|GO:0005524|GO:0005737|GO:0006421 KEGG: 00970+6.1.1.22|Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 Gene3D G3DSA:2.40.50.140 4 98 3.5E-15 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 Pfam PF01336 OB-fold nucleic acid binding domain 19 94 4.3E-9 T 21-04-2016 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 Pfam PF00152 tRNA synthetases class II (D, K and N) 112 475 1.2E-85 T 21-04-2016 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N) GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 TIGRFAM TIGR00457 asnS: asparagine--tRNA ligase 5 481 1.7E-180 T 21-04-2016 IPR004522 Asparagine-tRNA ligase GO:0000166|GO:0004816|GO:0005524|GO:0005737|GO:0006421 KEGG: 00970+6.1.1.22|Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PANTHER PTHR22594 192 480 2.3E-223 T 21-04-2016 IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PANTHER PTHR22594 1 173 2.3E-223 T 21-04-2016 IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PANTHER PTHR22594:SF6 192 480 2.3E-223 T 21-04-2016 IPR004522 Asparagine-tRNA ligase GO:0000166|GO:0004816|GO:0005524|GO:0005737|GO:0006421 KEGG: 00970+6.1.1.22|Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PANTHER PTHR22594:SF6 1 173 2.3E-223 T 21-04-2016 IPR004522 Asparagine-tRNA ligase GO:0000166|GO:0004816|GO:0005524|GO:0005737|GO:0006421 KEGG: 00970+6.1.1.22|Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PRINTS PR01042 Aspartyl-tRNA synthetase signature 436 450 4.5E-14 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PRINTS PR01042 Aspartyl-tRNA synthetase signature 201 213 4.5E-14 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PRINTS PR01042 Aspartyl-tRNA synthetase signature 396 412 4.5E-14 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS16620 73122898ed587f0d86e660c45a4c7172 481 PRINTS PR01042 Aspartyl-tRNA synthetase signature 217 230 4.5E-14 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS23985 b65c15c63653928d1ee896ebd048da77 526 Pfam PF07690 Major Facilitator Superfamily 23 409 3.5E-9 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS23985 b65c15c63653928d1ee896ebd048da77 526 Gene3D G3DSA:1.20.1250.20 21 194 3.1E-6 T 21-04-2016 SPH21_RS23985 b65c15c63653928d1ee896ebd048da77 526 SUPERFAMILY SSF103473 10 203 1.31E-12 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS23985 b65c15c63653928d1ee896ebd048da77 526 SUPERFAMILY SSF103473 491 517 1.31E-12 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS23985 b65c15c63653928d1ee896ebd048da77 526 SUPERFAMILY SSF103473 255 427 1.31E-12 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS23985 b65c15c63653928d1ee896ebd048da77 526 PANTHER PTHR23501 9 525 2.1E-14 T 21-04-2016 SPH21_RS25095 165f4d97be6e1a058e220bbcf5fa2a3c 182 PANTHER PTHR33567 2 182 2.4E-57 T 21-04-2016 SPH21_RS25095 165f4d97be6e1a058e220bbcf5fa2a3c 182 Pfam PF02417 Chromate transporter 5 179 3.3E-51 T 21-04-2016 IPR003370 Chromate transporter GO:0015109|GO:0015703 SPH21_RS15175 173954b65cd6b7646424ef7f349413e2 369 PANTHER PTHR41368 1 369 1.4E-72 T 21-04-2016 SPH21_RS15175 173954b65cd6b7646424ef7f349413e2 369 Gene3D G3DSA:3.40.630.30 209 356 8.2E-6 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15175 173954b65cd6b7646424ef7f349413e2 369 SUPERFAMILY SSF55729 3 110 1.04E-20 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15175 173954b65cd6b7646424ef7f349413e2 369 SUPERFAMILY SSF55729 138 357 1.04E-20 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS24045 96af5f0478a2547b060eb579b97aca5e 119 Pfam PF03795 YCII-related domain 22 111 3.3E-6 T 21-04-2016 IPR005545 YCII-related SPH21_RS24045 96af5f0478a2547b060eb579b97aca5e 119 SUPERFAMILY SSF54909 17 115 1.39E-10 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS24045 96af5f0478a2547b060eb579b97aca5e 119 Gene3D G3DSA:3.30.70.1060 1 114 5.7E-16 T 21-04-2016 SPH21_RS16810 6217771cec8408c473445842cce388c0 317 SUPERFAMILY SSF51430 4 314 1.44E-92 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS16810 6217771cec8408c473445842cce388c0 317 PANTHER PTHR11732:SF132 2 314 3.7E-126 T 21-04-2016 SPH21_RS16810 6217771cec8408c473445842cce388c0 317 Gene3D G3DSA:3.20.20.100 4 315 3.0E-95 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS16810 6217771cec8408c473445842cce388c0 317 Pfam PF00248 Aldo/keto reductase family 16 314 8.0E-72 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS16810 6217771cec8408c473445842cce388c0 317 PANTHER PTHR11732 2 314 3.7E-126 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS06520 cbe49f273969f8eda371d220172a5368 176 Gene3D G3DSA:3.30.1320.10 3 84 1.6E-32 T 21-04-2016 IPR023803 Ribosomal protein S16 domain SPH21_RS06520 cbe49f273969f8eda371d220172a5368 176 Hamap MF_00385 30S ribosomal protein S16 [rpsP]. 2 77 23.659 T 21-04-2016 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06520 cbe49f273969f8eda371d220172a5368 176 SUPERFAMILY SSF54565 3 99 1.29E-34 T 21-04-2016 IPR023803 Ribosomal protein S16 domain SPH21_RS06520 cbe49f273969f8eda371d220172a5368 176 TIGRFAM TIGR00002 S16: ribosomal protein bS16 4 79 1.0E-30 T 21-04-2016 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06520 cbe49f273969f8eda371d220172a5368 176 Pfam PF00886 Ribosomal protein S16 9 67 1.0E-24 T 21-04-2016 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS06520 cbe49f273969f8eda371d220172a5368 176 PANTHER PTHR12919 2 163 2.6E-42 T 21-04-2016 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS16140 262f73c40f6453197c7202f6b8de9483 243 Gene3D G3DSA:3.60.15.10 27 242 8.0E-49 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS16140 262f73c40f6453197c7202f6b8de9483 243 SMART SM00849 56 225 4.6E-15 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS16140 262f73c40f6453197c7202f6b8de9483 243 SUPERFAMILY SSF56281 31 242 3.93E-37 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS16140 262f73c40f6453197c7202f6b8de9483 243 Pfam PF00753 Metallo-beta-lactamase superfamily 54 225 1.6E-7 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS16140 262f73c40f6453197c7202f6b8de9483 243 ProSitePatterns PS00744 Beta-lactamases class B signature 2. 175 187 - T 21-04-2016 IPR001018 Beta-lactamase, class-B, conserved site GO:0008270|GO:0008800|GO:0017001 SPH21_RS06810 91f2d3ec23116bf02e30a17715fb5699 370 Gene3D G3DSA:3.20.20.70 36 359 6.5E-42 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS06810 91f2d3ec23116bf02e30a17715fb5699 370 SMART SM00876 255 358 1.4E-33 T 21-04-2016 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS06810 91f2d3ec23116bf02e30a17715fb5699 370 PANTHER PTHR22976:SF17 1 367 1.1E-170 T 21-04-2016 SPH21_RS06810 91f2d3ec23116bf02e30a17715fb5699 370 TIGRFAM TIGR02351 thiH: thiazole biosynthesis protein ThiH 2 365 1.3E-157 T 21-04-2016 IPR012726 Thiazole biosynthesis ThiH GO:0005506|GO:0009228|GO:0051539 KEGG: 00730+4.1.99.19|MetaCyc: PWY-6892|UniPathway: UPA00060 SPH21_RS06810 91f2d3ec23116bf02e30a17715fb5699 370 Pfam PF06968 Biotin and Thiamin Synthesis associated domain 255 356 6.3E-27 T 21-04-2016 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380|UniPathway: UPA00078 SPH21_RS06810 91f2d3ec23116bf02e30a17715fb5699 370 PANTHER PTHR22976 1 367 1.1E-170 T 21-04-2016 SPH21_RS06810 91f2d3ec23116bf02e30a17715fb5699 370 SUPERFAMILY SSF102114 35 360 2.88E-46 T 21-04-2016 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 TIGRFAM TIGR00262 trpA: tryptophan synthase, alpha subunit 11 252 4.3E-70 T 21-04-2016 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 PANTHER PTHR10314 22 49 2.0E-23 T 21-04-2016 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 PANTHER PTHR10314 72 166 2.0E-23 T 21-04-2016 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 PANTHER PTHR10314:SF4 22 49 2.0E-23 T 21-04-2016 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 PANTHER PTHR10314:SF4 72 166 2.0E-23 T 21-04-2016 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 Gene3D G3DSA:3.20.20.70 1 257 8.2E-90 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 SUPERFAMILY SSF51366 1 242 3.38E-80 T 21-04-2016 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 Hamap MF_00131 Tryptophan synthase alpha chain [trpA]. 11 258 31.001 T 21-04-2016 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 ProSitePatterns PS00167 Tryptophan synthase alpha chain signature. 46 59 - T 21-04-2016 IPR018204 Tryptophan synthase, alpha chain, active site GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15440 37c20d7e38a3b08e7da708e08c1ec70a 261 Pfam PF00290 Tryptophan synthase alpha chain 12 242 2.6E-74 T 21-04-2016 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20|UniPathway: UPA00035 SPH21_RS15645 23b83ee249f72e4dcf9662ccac7c7c89 164 TIGRFAM TIGR00040 yfcE: phosphodiesterase, MJ0936 family 3 153 2.9E-16 T 21-04-2016 IPR000979 Phosphodiesterase MJ0936/Vps29 SPH21_RS15645 23b83ee249f72e4dcf9662ccac7c7c89 164 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 3 150 1.3E-24 T 21-04-2016 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type SPH21_RS15645 23b83ee249f72e4dcf9662ccac7c7c89 164 SUPERFAMILY SSF56300 1 161 3.37E-28 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS15645 23b83ee249f72e4dcf9662ccac7c7c89 164 Gene3D G3DSA:3.60.21.10 3 154 9.3E-24 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS15645 23b83ee249f72e4dcf9662ccac7c7c89 164 PANTHER PTHR11124 1 164 1.6E-16 T 21-04-2016 IPR000979 Phosphodiesterase MJ0936/Vps29 SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 Pfam PF00255 Glutathione peroxidase 19 124 4.7E-35 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 Gene3D G3DSA:3.40.30.10 18 164 2.3E-55 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 PIRSF PIRSF000303 1 170 2.3E-57 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 PANTHER PTHR11592 1 163 6.0E-62 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 SUPERFAMILY SSF52833 18 163 3.8E-50 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 PRINTS PR01011 Glutathione peroxidase family signature 71 87 1.7E-17 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 PRINTS PR01011 Glutathione peroxidase family signature 136 145 1.7E-17 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 PRINTS PR01011 Glutathione peroxidase family signature 37 54 1.7E-17 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS00155 14b284d219c8e14231beaa79551c887f 170 ProSitePatterns PS00460 Glutathione peroxidases active site. 39 54 - T 21-04-2016 IPR029759 Glutathione peroxidase active site SPH21_RS24875 f780cd017a7e6c6a3857f0dd6ea635fd 148 SUPERFAMILY SSF54593 28 145 1.69E-9 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS24875 f780cd017a7e6c6a3857f0dd6ea635fd 148 Gene3D G3DSA:3.10.180.10 31 146 7.7E-10 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS01715 e7b442d0dabfc156ed7abefb13bf754f 390 Gene3D G3DSA:2.40.160.10 26 368 7.6E-32 T 21-04-2016 IPR023614 Porin domain SPH21_RS01715 e7b442d0dabfc156ed7abefb13bf754f 390 Pfam PF07396 Phosphate-selective porin O and P 45 367 2.7E-10 T 21-04-2016 IPR010870 Phosphate-selective porin O/P SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 Pfam PF14226 non-haem dioxygenase in morphine synthesis N-terminal 13 114 9.6E-25 T 21-04-2016 IPR026992 Non-haem dioxygenase N-terminal domain SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 PRINTS PR00682 Isopenicillin N synthase signature 306 322 5.0E-11 T 21-04-2016 IPR002283 Isopenicillin N synthase GO:0005506|GO:0016491|GO:0055114 SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 PRINTS PR00682 Isopenicillin N synthase signature 31 48 5.0E-11 T 21-04-2016 IPR002283 Isopenicillin N synthase GO:0005506|GO:0016491|GO:0055114 SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 PRINTS PR00682 Isopenicillin N synthase signature 237 263 5.0E-11 T 21-04-2016 IPR002283 Isopenicillin N synthase GO:0005506|GO:0016491|GO:0055114 SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 PRINTS PR00682 Isopenicillin N synthase signature 201 222 5.0E-11 T 21-04-2016 IPR002283 Isopenicillin N synthase GO:0005506|GO:0016491|GO:0055114 SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 SUPERFAMILY SSF51197 4 318 7.55E-82 T 21-04-2016 SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 PANTHER PTHR10209:SF146 3 322 1.2E-82 T 21-04-2016 SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 Gene3D G3DSA:2.60.120.330 7 317 5.4E-84 T 21-04-2016 IPR027443 Isopenicillin N synthase-like SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 Pfam PF03171 2OG-Fe(II) oxygenase superfamily 180 281 1.2E-15 T 21-04-2016 IPR005123 Oxoglutarate/iron-dependent dioxygenase GO:0016491|GO:0055114 SPH21_RS25830 205949b192887eb8e7c6fa8ee53722a7 322 PANTHER PTHR10209 3 322 1.2E-82 T 21-04-2016 SPH21_RS22150 816286419a416b151715608521dcd330 285 PRINTS PR00046 Major sigma-70 factor signature 261 272 1.4E-18 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 PRINTS PR00046 Major sigma-70 factor signature 78 91 1.4E-18 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 PRINTS PR00046 Major sigma-70 factor signature 246 261 1.4E-18 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 PRINTS PR00046 Major sigma-70 factor signature 102 110 1.4E-18 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 PRINTS PR00046 Major sigma-70 factor signature 225 237 1.4E-18 T 21-04-2016 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 PANTHER PTHR30603 2 285 9.9E-68 T 21-04-2016 SPH21_RS22150 816286419a416b151715608521dcd330 285 Gene3D G3DSA:1.10.10.10 127 169 1.9E-9 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22150 816286419a416b151715608521dcd330 285 SUPERFAMILY SSF88946 13 123 3.92E-37 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 Pfam PF04545 Sigma-70, region 4 221 273 3.5E-12 T 21-04-2016 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 Pfam PF04539 Sigma-70 region 3 134 205 1.5E-10 T 21-04-2016 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 PANTHER PTHR30603:SF0 2 285 9.9E-68 T 21-04-2016 SPH21_RS22150 816286419a416b151715608521dcd330 285 SUPERFAMILY SSF88659 127 199 4.14E-9 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 Gene3D G3DSA:1.10.601.10 13 123 7.1E-42 T 21-04-2016 SPH21_RS22150 816286419a416b151715608521dcd330 285 Pfam PF04542 Sigma-70 region 2 56 122 7.8E-16 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 Gene3D G3DSA:1.10.10.10 218 281 2.6E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22150 816286419a416b151715608521dcd330 285 SUPERFAMILY SSF88659 190 276 1.14E-17 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 50 274 3.9E-30 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22150 816286419a416b151715608521dcd330 285 Pfam PF00140 Sigma-70 factor, region 1.2 17 49 1.3E-10 T 21-04-2016 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS23990 fecbc4693b8a164d275f8098f52f1474 348 Gene3D G3DSA:2.40.50.100 56 86 5.7E-17 T 21-04-2016 SPH21_RS23990 fecbc4693b8a164d275f8098f52f1474 348 Gene3D G3DSA:2.40.50.100 217 250 5.7E-17 T 21-04-2016 SPH21_RS23990 fecbc4693b8a164d275f8098f52f1474 348 SUPERFAMILY SSF111369 193 268 1.19E-9 T 21-04-2016 SPH21_RS23990 fecbc4693b8a164d275f8098f52f1474 348 PANTHER PTHR30386:SF0 15 348 3.3E-74 T 21-04-2016 SPH21_RS23990 fecbc4693b8a164d275f8098f52f1474 348 SUPERFAMILY SSF111369 55 108 9.55E-9 T 21-04-2016 SPH21_RS23990 fecbc4693b8a164d275f8098f52f1474 348 PANTHER PTHR30386 15 348 3.3E-74 T 21-04-2016 SPH21_RS23990 fecbc4693b8a164d275f8098f52f1474 348 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 51 296 1.4E-17 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 PANTHER PTHR23514:SF10 193 420 4.3E-155 T 21-04-2016 SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 PANTHER PTHR23514:SF10 11 175 4.3E-155 T 21-04-2016 SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 SUPERFAMILY SSF103473 10 416 1.57E-36 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 Gene3D G3DSA:1.20.1250.20 245 413 1.0E-4 T 21-04-2016 SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 Gene3D G3DSA:1.20.1250.20 18 216 7.4E-17 T 21-04-2016 SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 Pfam PF07690 Major Facilitator Superfamily 23 382 3.3E-17 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 PANTHER PTHR23514 193 420 4.3E-155 T 21-04-2016 SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 PANTHER PTHR23514 11 175 4.3E-155 T 21-04-2016 SPH21_RS07085 06df0d6ed95036caa6482d2451b83ddd 423 TIGRFAM TIGR01272 gluP: glucose/galactose transporter WARNING 97 413 2.1E-89 T 21-04-2016 IPR005964 Bacterial glucose/galactose transporter GO:0005354|GO:0005355|GO:0009276|GO:0015757|GO:0015758|GO:0016021 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 SUPERFAMILY SSF53743 1 326 2.22E-119 T 21-04-2016 IPR009015 L-fucose isomerase, N-terminal/central domain GO:0005737|GO:0005996|GO:0016861 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 Pfam PF02610 L-arabinose isomerase 5 359 6.4E-178 T 21-04-2016 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4|UniPathway: UPA00145 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 SUPERFAMILY SSF50443 330 496 1.18E-70 T 21-04-2016 IPR004216 L-fucose/L-arabinose isomerase, C-terminal SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 Pfam PF11762 L-arabinose isomerase C-terminal domain 362 475 9.4E-52 T 21-04-2016 IPR024664 L-arabinose isomerase, C-terminal KEGG: 00040+5.3.1.4|UniPathway: UPA00145 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 PIRSF PIRSF001478 1 499 4.4E-241 T 21-04-2016 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4|UniPathway: UPA00145 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 PANTHER PTHR38464:SF1 2 499 2.1E-200 T 21-04-2016 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 ProDom PD018364 ISOMERASE L-ARABINOSE ARABINOSE METABOLISM CARBOHYDRATE CATABOLISM ARAA 1 303 2.0E-101 T 21-04-2016 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4|UniPathway: UPA00145 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 Hamap MF_00519 L-arabinose isomerase [araA]. 1 476 62.762 T 21-04-2016 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4|UniPathway: UPA00145 SPH21_RS05065 4316fbbf20e7a49824bfd17c8de3f7f5 499 PANTHER PTHR38464 2 499 2.1E-200 T 21-04-2016 SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 TIGRFAM TIGR00611 recf: DNA replication and repair protein RecF 1 364 4.9E-87 T 21-04-2016 IPR001238 DNA-binding, RecF GO:0003697|GO:0005524|GO:0006281 SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 PANTHER PTHR32182 1 347 6.7E-49 T 21-04-2016 SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 SUPERFAMILY SSF52540 1 346 1.6E-44 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 PANTHER PTHR32182:SF0 1 347 6.7E-49 T 21-04-2016 IPR001238 DNA-binding, RecF GO:0003697|GO:0005524|GO:0006281 SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 Gene3D G3DSA:3.40.50.300 1 167 5.0E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 Gene3D G3DSA:3.40.50.300 231 351 5.0E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 ProSitePatterns PS00617 RecF protein signature 1. 117 137 - T 21-04-2016 IPR018078 DNA-binding, RecF, conserved site GO:0003697|GO:0005524|GO:0006281 SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 Pfam PF02463 RecF/RecN/SMC N terminal domain 3 358 1.0E-18 T 21-04-2016 IPR003395 RecF/RecN/SMC, N-terminal SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 Hamap MF_00365 DNA replication and repair protein RecF [recF]. 1 365 81.282 T 21-04-2016 IPR001238 DNA-binding, RecF GO:0003697|GO:0005524|GO:0006281 SPH21_RS25885 8de98956dbf0057bc5aa06eed52b24cf 365 ProSitePatterns PS00618 RecF protein signature 2. 303 321 - T 21-04-2016 IPR018078 DNA-binding, RecF, conserved site GO:0003697|GO:0005524|GO:0006281 SPH21_RS14045 c3be51e5f4f6cb17d8ddc58f4cebc93f 153 PANTHER PTHR23091:SF226 18 136 1.1E-21 T 21-04-2016 SPH21_RS14045 c3be51e5f4f6cb17d8ddc58f4cebc93f 153 Gene3D G3DSA:3.40.630.30 21 145 7.4E-22 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS14045 c3be51e5f4f6cb17d8ddc58f4cebc93f 153 SUPERFAMILY SSF55729 18 152 1.26E-23 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS14045 c3be51e5f4f6cb17d8ddc58f4cebc93f 153 Pfam PF13508 Acetyltransferase (GNAT) domain 38 119 8.5E-12 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS14045 c3be51e5f4f6cb17d8ddc58f4cebc93f 153 PANTHER PTHR23091 18 136 1.1E-21 T 21-04-2016 SPH21_RS15430 4b6d52dabed6095d9216f8cdc6c824ab 207 PANTHER PTHR22854:SF6 2 201 1.3E-46 T 21-04-2016 SPH21_RS15430 4b6d52dabed6095d9216f8cdc6c824ab 207 Gene3D G3DSA:3.20.20.70 4 205 7.2E-62 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15430 4b6d52dabed6095d9216f8cdc6c824ab 207 SUPERFAMILY SSF51366 4 203 1.0E-50 T 21-04-2016 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SPH21_RS15430 4b6d52dabed6095d9216f8cdc6c824ab 207 Hamap MF_00135 N-(5'-phosphoribosyl)anthranilate isomerase [trpF]. 3 207 31.063 T 21-04-2016 IPR001240 N-(5'phosphoribosyl) anthranilate isomerase (PRAI) GO:0004640|GO:0006568 KEGG: 00400+5.3.1.24|UniPathway: UPA00035 SPH21_RS15430 4b6d52dabed6095d9216f8cdc6c824ab 207 Pfam PF00697 N-(5'phosphoribosyl)anthranilate (PRA) isomerase 6 202 7.7E-44 T 21-04-2016 IPR001240 N-(5'phosphoribosyl) anthranilate isomerase (PRAI) GO:0004640|GO:0006568 KEGG: 00400+5.3.1.24|UniPathway: UPA00035 SPH21_RS15430 4b6d52dabed6095d9216f8cdc6c824ab 207 PANTHER PTHR22854 2 201 1.3E-46 T 21-04-2016 SPH21_RS20415 d6cbbfb6d2a05a0f64a0c569edbc786a 333 PANTHER PTHR31155:SF9 1 330 1.7E-137 T 21-04-2016 SPH21_RS20415 d6cbbfb6d2a05a0f64a0c569edbc786a 333 PANTHER PTHR31155 1 330 1.7E-137 T 21-04-2016 SPH21_RS20415 d6cbbfb6d2a05a0f64a0c569edbc786a 333 PIRSF PIRSF000346 2 333 5.3E-113 T 21-04-2016 IPR005067 Fatty acid desaturase, type 2 GO:0006631|GO:0045300|GO:0055114 UniPathway: UPA00199 SPH21_RS20415 d6cbbfb6d2a05a0f64a0c569edbc786a 333 Gene3D G3DSA:1.10.620.20 9 331 4.2E-125 T 21-04-2016 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: REACT_1698 SPH21_RS20415 d6cbbfb6d2a05a0f64a0c569edbc786a 333 SUPERFAMILY SSF47240 10 331 6.6E-97 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS20415 d6cbbfb6d2a05a0f64a0c569edbc786a 333 Pfam PF03405 Fatty acid desaturase 13 330 3.2E-137 T 21-04-2016 IPR005067 Fatty acid desaturase, type 2 GO:0006631|GO:0045300|GO:0055114 UniPathway: UPA00199 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 Pfam PF01595 Domain of unknown function DUF21 5 194 3.4E-46 T 21-04-2016 IPR002550 Domain of unknown function DUF21 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 Gene3D G3DSA:3.10.580.10 197 323 3.1E-12 T 21-04-2016 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 PANTHER PTHR22777 1 424 7.1E-156 T 21-04-2016 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 PANTHER PTHR22777:SF8 1 424 7.1E-156 T 21-04-2016 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 Gene3D G3DSA:3.30.465.10 324 422 1.1E-23 T 21-04-2016 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 SUPERFAMILY SSF54631 199 331 1.46E-23 T 21-04-2016 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 Pfam PF00571 CBS domain 284 329 0.0057 T 21-04-2016 IPR000644 CBS domain SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 Pfam PF03471 Transporter associated domain 344 422 1.4E-19 T 21-04-2016 IPR005170 Transporter-associated domain SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 SUPERFAMILY SSF56176 340 421 2.7E-20 T 21-04-2016 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SPH21_RS18325 eeeea7a24ecbb6150d6696ec5f46f907 424 SMART SM01091 343 423 2.9E-25 T 21-04-2016 IPR005170 Transporter-associated domain SPH21_RS20310 e4419f38de609adbc7c20f1e51613ed0 281 Gene3D G3DSA:3.40.1350.10 70 215 3.2E-37 T 21-04-2016 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 SPH21_RS20310 e4419f38de609adbc7c20f1e51613ed0 281 SUPERFAMILY SSF52980 83 212 7.08E-20 T 21-04-2016 IPR011335 Restriction endonuclease type II-like SPH21_RS20310 e4419f38de609adbc7c20f1e51613ed0 281 Pfam PF03477 ATP cone domain 1 79 9.5E-6 T 21-04-2016 IPR005144 ATP-cone domain SPH21_RS20310 e4419f38de609adbc7c20f1e51613ed0 281 Pfam PF04471 Restriction endonuclease 84 198 2.2E-6 T 21-04-2016 IPR007560 Restriction endonuclease type IV, Mrr GO:0003677|GO:0004519|GO:0009307 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 SMART SM00977 367 441 6.6E-19 T 21-04-2016 IPR012796 Lysidine-tRNA(Ile) synthetase, C-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 TIGRFAM TIGR02433 lysidine_TilS_C: tRNA(Ile)-lysidine synthetase, C-terminal domain 367 413 4.3E-14 T 21-04-2016 IPR012796 Lysidine-tRNA(Ile) synthetase, C-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 Hamap MF_01161 tRNA(Ile)-lysidine synthase [tilS]. 4 305 22.226 T 21-04-2016 IPR012094 tRNA(Ile)-lysidine synthase GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 PANTHER PTHR11807 3 443 7.3E-81 T 21-04-2016 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 Gene3D G3DSA:3.40.50.620 18 180 2.9E-15 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 SUPERFAMILY SSF52402 4 206 2.79E-50 T 21-04-2016 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 TIGRFAM TIGR02432 lysidine_TilS_N: tRNA(Ile)-lysidine synthetase 23 202 1.6E-50 T 21-04-2016 IPR012795 tRNA(Ile)-lysidine synthase, N-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 Pfam PF01171 PP-loop family 23 197 8.1E-47 T 21-04-2016 IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 PANTHER PTHR11807:SF2 3 443 7.3E-81 T 21-04-2016 IPR012094 tRNA(Ile)-lysidine synthase GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 Pfam PF11734 TilS substrate C-terminal domain 369 437 2.4E-8 T 21-04-2016 IPR012796 Lysidine-tRNA(Ile) synthetase, C-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SPH21_RS08020 9c33a817aa502c340022e0d616d8cae9 443 SUPERFAMILY SSF56037 324 438 1.36E-15 T 21-04-2016 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 Pfam PF01019 Gamma-glutamyltranspeptidase 49 628 7.7E-103 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 SUPERFAMILY SSF56235 23 383 2.83E-123 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 SUPERFAMILY SSF56235 438 638 2.83E-123 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 498 513 1.8E-9 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 125 143 1.8E-9 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 143 162 1.8E-9 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 55 80 1.8E-9 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 PANTHER PTHR11686 4 221 4.3E-99 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 PANTHER PTHR11686 239 377 4.3E-99 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS25185 86d17250f18ee2f32956856ece7a3955 638 PANTHER PTHR11686 430 627 4.3E-99 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 11 119 1.2E-15 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 PANTHER PTHR22604 1 347 7.7E-87 T 21-04-2016 SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 PANTHER PTHR22604:SF53 1 347 7.7E-87 T 21-04-2016 SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 133 213 1.4E-5 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 SUPERFAMILY SSF51735 3 154 2.73E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 Gene3D G3DSA:3.40.50.720 1 128 4.8E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 Gene3D G3DSA:3.30.360.10 129 342 6.8E-27 T 21-04-2016 SPH21_RS05835 24ffc6d55617e19caf70d1560863bab1 347 SUPERFAMILY SSF55347 128 285 2.14E-19 T 21-04-2016 SPH21_RS23415 381f64c289745966850fc0753ae7f64c 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 59 7.6E-7 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS23415 381f64c289745966850fc0753ae7f64c 197 SUPERFAMILY SSF46689 7 69 8.72E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23415 381f64c289745966850fc0753ae7f64c 197 Gene3D G3DSA:1.10.10.60 9 60 3.3E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23415 381f64c289745966850fc0753ae7f64c 197 SUPERFAMILY SSF48498 88 171 4.8E-5 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS23415 381f64c289745966850fc0753ae7f64c 197 Gene3D G3DSA:1.10.357.10 61 195 5.7E-13 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS23415 381f64c289745966850fc0753ae7f64c 197 PANTHER PTHR30055 3 169 7.1E-15 T 21-04-2016 SPH21_RS10430 271a2961e68ab795404b6cbd07e91d1b 147 Pfam PF12900 Pyridoxamine 5'-phosphate oxidase 7 140 3.8E-23 T 21-04-2016 IPR024747 Pyridoxamine 5'-phosphate oxidase-related SPH21_RS10430 271a2961e68ab795404b6cbd07e91d1b 147 PANTHER PTHR34071 6 140 8.0E-20 T 21-04-2016 SPH21_RS10430 271a2961e68ab795404b6cbd07e91d1b 147 Gene3D G3DSA:2.30.110.10 2 145 1.7E-38 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS10430 271a2961e68ab795404b6cbd07e91d1b 147 SUPERFAMILY SSF50475 4 140 1.34E-30 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532 410 466 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532 302 360 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532 1 285 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532 497 1021 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532:SF57 410 466 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532:SF57 302 360 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532:SF57 1 285 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 PANTHER PTHR11532:SF57 497 1021 1.4E-271 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Gene3D G3DSA:2.60.40.1120 26 114 4.1E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 SUPERFAMILY SSF56935 425 770 2.08E-101 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 SUPERFAMILY SSF56935 103 258 2.08E-101 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 SUPERFAMILY SSF56935 931 1021 2.08E-101 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 SUPERFAMILY SSF56935 843 887 2.08E-101 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 SUPERFAMILY SSF56935 306 394 2.08E-101 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Gene3D G3DSA:2.170.130.10 115 237 2.2E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Pfam PF00593 TonB dependent receptor 599 1021 2.5E-24 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 SUPERFAMILY SSF49464 25 105 2.22E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 25 1022 3.6E-273 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Pfam PF07715 TonB-dependent Receptor Plug Domain 115 234 5.7E-24 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Pfam PF13715 CarboxypepD_reg-like domain 27 107 1.4E-16 T 21-04-2016 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Gene3D G3DSA:2.40.170.20 922 1021 3.1E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Gene3D G3DSA:2.40.170.20 315 779 3.1E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Gene3D G3DSA:2.40.170.20 852 877 3.1E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 Gene3D G3DSA:2.40.170.20 238 257 3.1E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS14130 a052449d9e186ac54bdca23929e97165 1023 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 210 240 1.0E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 Gene3D G3DSA:1.20.1560.10 30 345 9.8E-78 T 21-04-2016 SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 ProSitePatterns PS00211 ABC transporters family signature. 505 519 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 Pfam PF00005 ABC transporter 384 533 1.1E-35 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 Gene3D G3DSA:3.40.50.300 366 597 2.6E-85 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 SUPERFAMILY SSF90123 30 347 6.67E-74 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 SMART SM00382 393 579 9.2E-21 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 Pfam PF00664 ABC transporter transmembrane region 43 316 1.1E-54 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 PANTHER PTHR24221 14 606 1.3E-244 T 21-04-2016 SPH21_RS12525 f3bf57441bcd1786d4dc80e31a7f05c1 610 SUPERFAMILY SSF52540 358 604 2.0E-91 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17800 91f11e7393e51cdc24f53c6058b0b8d4 96 SUPERFAMILY SSF47413 1 63 1.72E-11 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS17800 91f11e7393e51cdc24f53c6058b0b8d4 96 Gene3D G3DSA:1.10.260.40 3 76 4.9E-13 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS17800 91f11e7393e51cdc24f53c6058b0b8d4 96 Pfam PF12844 Helix-turn-helix domain 4 63 3.2E-10 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS17800 91f11e7393e51cdc24f53c6058b0b8d4 96 SMART SM00530 6 61 3.8E-7 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS03940 e2b4be9062089211b83a2782229aa247 588 Pfam PF14322 Starch-binding associating with outer membrane 93 203 9.1E-9 T 21-04-2016 SPH21_RS03940 e2b4be9062089211b83a2782229aa247 588 Pfam PF07980 SusD family 266 588 3.4E-39 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS03940 e2b4be9062089211b83a2782229aa247 588 Gene3D G3DSA:1.25.40.10 187 300 1.1E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03940 e2b4be9062089211b83a2782229aa247 588 Gene3D G3DSA:1.25.40.10 360 466 1.1E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03940 e2b4be9062089211b83a2782229aa247 588 SUPERFAMILY SSF48452 16 493 1.2E-93 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03940 e2b4be9062089211b83a2782229aa247 588 SUPERFAMILY SSF48452 556 588 1.2E-93 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05850 604c96e947a151ead8b9be1a905689df 80 Gene3D G3DSA:1.10.720.30 18 74 1.2E-29 T 21-04-2016 IPR003034 SAP domain SPH21_RS05850 604c96e947a151ead8b9be1a905689df 80 Pfam PF09905 Uncharacterized conserved protein (DUF2132) 10 72 8.3E-34 T 21-04-2016 IPR018668 DNA-binding protein VF530-like, bacteria GO:0003677 SPH21_RS07865 433cc5740aab5c3a6dfc2ca7d62ddeb2 167 Hamap MF_01357 NAD(P)H-quinone oxidoreductase subunit J, chloroplastic [ndhJ]. 9 162 26.834 T 21-04-2016 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 SPH21_RS07865 433cc5740aab5c3a6dfc2ca7d62ddeb2 167 TIGRFAM TIGR01961 NuoC_fam: NADH (or F420H2) dehydrogenase, subunit C 33 153 4.2E-40 T 21-04-2016 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 SPH21_RS07865 433cc5740aab5c3a6dfc2ca7d62ddeb2 167 ProDom PD001581 OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE CHAIN C NAD DEHYDROGENASE UBIQUINONE F420H2 84 136 4.0E-15 T 21-04-2016 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 SPH21_RS07865 433cc5740aab5c3a6dfc2ca7d62ddeb2 167 SUPERFAMILY SSF143243 9 157 1.96E-46 T 21-04-2016 SPH21_RS07865 433cc5740aab5c3a6dfc2ca7d62ddeb2 167 Pfam PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 34 154 1.2E-40 T 21-04-2016 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 SPH21_RS07865 433cc5740aab5c3a6dfc2ca7d62ddeb2 167 PANTHER PTHR10884 12 152 6.6E-50 T 21-04-2016 SPH21_RS07865 433cc5740aab5c3a6dfc2ca7d62ddeb2 167 ProSitePatterns PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature. 115 136 - T 21-04-2016 IPR020396 NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site GO:0016651|GO:0055114 SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 PANTHER PTHR24031:SF0 4 441 5.7E-156 T 21-04-2016 SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 SUPERFAMILY SSF52540 72 362 6.17E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 PANTHER PTHR24031 4 441 5.7E-156 T 21-04-2016 SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 Pfam PF00271 Helicase conserved C-terminal domain 230 340 2.4E-26 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 SMART SM00487 22 220 5.0E-57 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 Gene3D G3DSA:3.40.50.300 212 373 1.1E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 ProSitePatterns PS00039 DEAD-box subfamily ATP-dependent helicases signature. 151 159 - T 21-04-2016 IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 SMART SM00490 258 341 2.3E-29 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 Pfam PF00270 DEAD/DEAH box helicase 27 193 8.4E-50 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS19290 8b2889b5bdf01d706ff15b95689bc922 442 Gene3D G3DSA:3.40.50.300 3 211 2.1E-77 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01760 57fc94c71c8f7e3d27ecfb1c1eb7ff8e 186 TIGRFAM TIGR01382 PfpI: intracellular protease, PfpI family 8 174 6.2E-53 T 21-04-2016 IPR006286 Peptidase C56, PfpI GO:0016798 SPH21_RS01760 57fc94c71c8f7e3d27ecfb1c1eb7ff8e 186 SUPERFAMILY SSF52317 7 176 1.72E-47 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS01760 57fc94c71c8f7e3d27ecfb1c1eb7ff8e 186 PANTHER PTHR11019:SF115 3 178 1.1E-69 T 21-04-2016 SPH21_RS01760 57fc94c71c8f7e3d27ecfb1c1eb7ff8e 186 PANTHER PTHR11019 3 178 1.1E-69 T 21-04-2016 SPH21_RS01760 57fc94c71c8f7e3d27ecfb1c1eb7ff8e 186 Gene3D G3DSA:3.40.50.880 3 178 1.7E-58 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS01760 57fc94c71c8f7e3d27ecfb1c1eb7ff8e 186 Pfam PF01965 DJ-1/PfpI family 7 175 3.2E-56 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS00360 42aedf6e397575b7e604ed31c285f79a 126 PANTHER PTHR11019:SF45 9 126 8.4E-17 T 21-04-2016 SPH21_RS00360 42aedf6e397575b7e604ed31c285f79a 126 Pfam PF12833 Helix-turn-helix domain 42 119 2.1E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS00360 42aedf6e397575b7e604ed31c285f79a 126 Gene3D G3DSA:1.10.10.60 76 121 1.1E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00360 42aedf6e397575b7e604ed31c285f79a 126 Gene3D G3DSA:1.10.10.10 7 61 6.3E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS00360 42aedf6e397575b7e604ed31c285f79a 126 SUPERFAMILY SSF46689 75 121 1.03E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00360 42aedf6e397575b7e604ed31c285f79a 126 PANTHER PTHR11019 9 126 8.4E-17 T 21-04-2016 SPH21_RS00360 42aedf6e397575b7e604ed31c285f79a 126 SMART SM00342 36 118 3.8E-9 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20105 005db313c92065b5748aa99780c55435 332 TIGRFAM TIGR03558 oxido_grp_1: luciferase family oxidoreductase, group 1 7 327 3.4E-127 T 21-04-2016 IPR019949 Luciferase family oxidoreductase, group 1 SPH21_RS20105 005db313c92065b5748aa99780c55435 332 PANTHER PTHR30137:SF2 1 330 1.1E-127 T 21-04-2016 SPH21_RS20105 005db313c92065b5748aa99780c55435 332 SUPERFAMILY SSF51679 6 327 3.93E-80 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS20105 005db313c92065b5748aa99780c55435 332 Pfam PF00296 Luciferase-like monooxygenase 23 304 6.3E-39 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS20105 005db313c92065b5748aa99780c55435 332 PANTHER PTHR30137 1 330 1.1E-127 T 21-04-2016 SPH21_RS20105 005db313c92065b5748aa99780c55435 332 Gene3D G3DSA:3.20.20.30 6 327 3.7E-87 T 21-04-2016 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 PANTHER PTHR24423 197 436 3.5E-43 T 21-04-2016 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 332 435 5.0E-18 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 SMART SM00387 329 436 4.0E-25 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 SMART SM00388 218 284 8.7E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 SUPERFAMILY SSF47384 203 284 2.16E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 Pfam PF00512 His Kinase A (phospho-acceptor) domain 220 283 2.4E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 SUPERFAMILY SSF55874 292 436 1.96E-32 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 Gene3D G3DSA:3.30.565.10 292 436 6.9E-30 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 Gene3D G3DSA:1.10.287.130 210 280 1.7E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 PRINTS PR00344 Bacterial sensor protein C-terminal signature 422 435 4.1E-10 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 PRINTS PR00344 Bacterial sensor protein C-terminal signature 398 416 4.1E-10 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 PRINTS PR00344 Bacterial sensor protein C-terminal signature 384 394 4.1E-10 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS02530 f1633ed4c12447d3ae5e93fc40a89b48 436 PRINTS PR00344 Bacterial sensor protein C-terminal signature 366 380 4.1E-10 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 122 1162 1.8E-198 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 PANTHER PTHR11532:SF51 92 290 1.6E-199 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 PANTHER PTHR11532:SF51 321 529 1.6E-199 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 PANTHER PTHR11532:SF51 604 1160 1.6E-199 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 SUPERFAMILY SSF56935 588 920 3.36E-83 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 SUPERFAMILY SSF56935 1071 1162 3.36E-83 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 SUPERFAMILY SSF56935 201 377 3.36E-83 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 SUPERFAMILY SSF56935 454 542 3.36E-83 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 SUPERFAMILY SSF56935 980 1023 3.36E-83 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 Gene3D G3DSA:2.170.130.10 205 354 9.9E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 Pfam PF07715 TonB-dependent Receptor Plug Domain 215 354 7.8E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 330 360 5.6E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 Gene3D G3DSA:2.40.170.20 459 528 2.1E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 Gene3D G3DSA:2.40.170.20 355 393 2.1E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 Gene3D G3DSA:2.40.170.20 590 1012 2.1E-44 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 Pfam PF13715 CarboxypepD_reg-like domain 122 204 4.9E-21 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 SUPERFAMILY SSF49464 121 202 2.35E-19 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 PANTHER PTHR11532 92 290 1.6E-199 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 PANTHER PTHR11532 321 529 1.6E-199 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 PANTHER PTHR11532 604 1160 1.6E-199 T 21-04-2016 SPH21_RS04760 e6f486484f532cafee66198e2650af4e 1162 Gene3D G3DSA:2.60.40.1120 122 204 1.5E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS24665 6f1a0245be4e3dc0796ca8f52d98552b 334 SUPERFAMILY SSF51430 4 314 4.71E-98 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS24665 6f1a0245be4e3dc0796ca8f52d98552b 334 Gene3D G3DSA:3.20.20.100 3 324 4.0E-112 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS24665 6f1a0245be4e3dc0796ca8f52d98552b 334 Pfam PF00248 Aldo/keto reductase family 22 314 2.6E-81 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS24665 6f1a0245be4e3dc0796ca8f52d98552b 334 PANTHER PTHR11732 3 315 2.2E-137 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 Pfam PF01433 Peptidase family M1 48 430 1.4E-63 T 21-04-2016 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 Gene3D G3DSA:1.25.10.10 598 680 8.8E-5 T 21-04-2016 IPR011989 Armadillo-like helical SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 Gene3D G3DSA:1.10.390.10 355 498 1.3E-35 T 21-04-2016 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 PANTHER PTHR11533 48 558 5.7E-88 T 21-04-2016 IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase GO:0006508 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 342 357 2.0E-7 T 21-04-2016 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 310 320 2.0E-7 T 21-04-2016 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 361 373 2.0E-7 T 21-04-2016 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 SUPERFAMILY SSF55486 257 497 4.4E-66 T 21-04-2016 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 SUPERFAMILY SSF48371 603 696 8.64E-6 T 21-04-2016 IPR016024 Armadillo-type fold GO:0005488 SPH21_RS08120 0e54a35aa341b9ff4c2116f82541a3de 702 SUPERFAMILY SSF63737 38 250 2.22E-28 T 21-04-2016 SPH21_RS10470 5960e1ac825a61848494b194b3c8a52c 354 Gene3D G3DSA:3.40.47.10 2 184 8.1E-40 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS10470 5960e1ac825a61848494b194b3c8a52c 354 PANTHER PTHR34069 1 354 3.0E-55 T 21-04-2016 SPH21_RS10470 5960e1ac825a61848494b194b3c8a52c 354 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 130 207 3.2E-18 T 21-04-2016 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS10470 5960e1ac825a61848494b194b3c8a52c 354 PANTHER PTHR34069:SF2 1 354 3.0E-55 T 21-04-2016 SPH21_RS10470 5960e1ac825a61848494b194b3c8a52c 354 Gene3D G3DSA:3.40.47.10 185 354 3.0E-31 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS10470 5960e1ac825a61848494b194b3c8a52c 354 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 255 354 9.9E-14 T 21-04-2016 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381|UniPathway: UPA00094 SPH21_RS10470 5960e1ac825a61848494b194b3c8a52c 354 SUPERFAMILY SSF53901 5 354 5.21E-44 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS06065 e3dca9f6036b7460fd1294eec6825bf9 263 PIRSF PIRSF004793 7 263 1.1E-73 T 21-04-2016 IPR014046 Diadenylate cyclase-like SPH21_RS06065 e3dca9f6036b7460fd1294eec6825bf9 263 Pfam PF02457 DisA bacterial checkpoint controller nucleotide-binding 128 245 1.5E-37 T 21-04-2016 IPR003390 DNA integrity scanning protein, DisA, N-terminal SPH21_RS06065 e3dca9f6036b7460fd1294eec6825bf9 263 PANTHER PTHR34185:SF1 4 261 1.0E-73 T 21-04-2016 SPH21_RS06065 e3dca9f6036b7460fd1294eec6825bf9 263 SUPERFAMILY SSF143597 41 249 1.07E-54 T 21-04-2016 SPH21_RS06065 e3dca9f6036b7460fd1294eec6825bf9 263 PANTHER PTHR34185 4 261 1.0E-73 T 21-04-2016 SPH21_RS06065 e3dca9f6036b7460fd1294eec6825bf9 263 Gene3D G3DSA:3.40.1700.10 123 250 8.9E-43 T 21-04-2016 SPH21_RS06065 e3dca9f6036b7460fd1294eec6825bf9 263 TIGRFAM TIGR00159 TIGR00159: TIGR00159 family protein 13 260 1.2E-62 T 21-04-2016 IPR014046 Diadenylate cyclase-like SPH21_RS13095 17f21e8d7c6b680ebbb2a7e87e22deb5 503 PANTHER PTHR11699:SF10 18 496 3.6E-113 T 21-04-2016 SPH21_RS13095 17f21e8d7c6b680ebbb2a7e87e22deb5 503 Pfam PF00171 Aldehyde dehydrogenase family 11 443 8.0E-39 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS13095 17f21e8d7c6b680ebbb2a7e87e22deb5 503 Gene3D G3DSA:3.40.605.10 11 240 1.6E-33 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS13095 17f21e8d7c6b680ebbb2a7e87e22deb5 503 SUPERFAMILY SSF53720 9 491 1.83E-87 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS13095 17f21e8d7c6b680ebbb2a7e87e22deb5 503 Gene3D G3DSA:3.40.309.10 242 431 1.3E-44 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS13095 17f21e8d7c6b680ebbb2a7e87e22deb5 503 PANTHER PTHR11699 18 496 3.6E-113 T 21-04-2016 SPH21_RS16975 1a53def14c99f9ac4b5153420dac9437 363 SUPERFAMILY SSF55874 245 357 9.03E-5 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS16975 1a53def14c99f9ac4b5153420dac9437 363 PANTHER PTHR34220 1 363 2.9E-38 T 21-04-2016 SPH21_RS16975 1a53def14c99f9ac4b5153420dac9437 363 Pfam PF06580 Histidine kinase 174 255 4.2E-20 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS14105 4fefcf02210e728951762c5b33929184 665 SUPERFAMILY SSF51905 27 69 7.12E-8 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14105 4fefcf02210e728951762c5b33929184 665 Pfam PF12831 FAD dependent oxidoreductase 30 513 1.4E-134 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14105 4fefcf02210e728951762c5b33929184 665 SUPERFAMILY SSF51905 252 373 7.12E-8 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14105 4fefcf02210e728951762c5b33929184 665 SUPERFAMILY SSF51905 13 184 2.71E-15 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14105 4fefcf02210e728951762c5b33929184 665 Gene3D G3DSA:3.50.50.60 26 177 9.2E-20 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 8 59 7.2E-7 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 Gene3D G3DSA:1.10.150.120 76 149 7.3E-29 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 SUPERFAMILY SSF54292 3 79 1.18E-23 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 SUPERFAMILY SSF47741 74 150 2.22E-29 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 PANTHER PTHR11908:SF66 1 135 7.0E-32 T 21-04-2016 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 Pfam PF01799 [2Fe-2S] binding domain 74 145 1.1E-26 T 21-04-2016 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 PANTHER PTHR11908 1 135 7.0E-32 T 21-04-2016 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 40 48 - T 21-04-2016 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SPH21_RS21200 9ace21942d02460fbd2c84a0ea0fd892 151 Gene3D G3DSA:3.10.20.30 3 75 8.1E-25 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS09385 e649a19c6dc4b515919c3d10c2e38eb5 560 SUPERFAMILY SSF48452 404 560 2.01E-82 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09385 e649a19c6dc4b515919c3d10c2e38eb5 560 SUPERFAMILY SSF48452 18 375 2.01E-82 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09385 e649a19c6dc4b515919c3d10c2e38eb5 560 Pfam PF07980 SusD family 271 560 8.2E-24 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09385 e649a19c6dc4b515919c3d10c2e38eb5 560 Gene3D G3DSA:1.25.40.10 204 303 9.6E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09385 e649a19c6dc4b515919c3d10c2e38eb5 560 Gene3D G3DSA:1.25.40.10 417 506 9.6E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07230 6c473f6204b07c0f69c9c7658c05121c 191 SUPERFAMILY SSF52972 1 190 4.71E-58 T 21-04-2016 IPR029001 Inosine triphosphate pyrophosphatase-like SPH21_RS07230 6c473f6204b07c0f69c9c7658c05121c 191 Hamap MF_01405 dITP/XTP pyrophosphatase [rdgB]. 2 190 42.812 T 21-04-2016 IPR020922 Non-canonical purine NTP pyrophosphatase GO:0009143|GO:0017111 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206 SPH21_RS07230 6c473f6204b07c0f69c9c7658c05121c 191 Pfam PF01725 Ham1 family 4 186 1.2E-54 T 21-04-2016 IPR002637 Ham1-like protein GO:0016787 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206 SPH21_RS07230 6c473f6204b07c0f69c9c7658c05121c 191 Gene3D G3DSA:3.90.950.10 1 190 2.0E-65 T 21-04-2016 IPR029001 Inosine triphosphate pyrophosphatase-like SPH21_RS07230 6c473f6204b07c0f69c9c7658c05121c 191 TIGRFAM TIGR00042 TIGR00042: non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family 4 188 4.7E-56 T 21-04-2016 IPR002637 Ham1-like protein GO:0016787 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206 SPH21_RS07230 6c473f6204b07c0f69c9c7658c05121c 191 PANTHER PTHR11067 1 191 5.1E-71 T 21-04-2016 IPR002637 Ham1-like protein GO:0016787 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206 SPH21_RS07230 6c473f6204b07c0f69c9c7658c05121c 191 PANTHER PTHR11067:SF9 1 191 5.1E-71 T 21-04-2016 SPH21_RS06005 0ef25f636e1162a404511abce0fd15e8 805 PANTHER PTHR30572:SF4 405 805 1.4E-59 T 21-04-2016 SPH21_RS06005 0ef25f636e1162a404511abce0fd15e8 805 PANTHER PTHR30572:SF4 291 359 1.4E-59 T 21-04-2016 SPH21_RS06005 0ef25f636e1162a404511abce0fd15e8 805 Pfam PF12704 MacB-like periplasmic core domain 20 243 2.0E-14 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS06005 0ef25f636e1162a404511abce0fd15e8 805 Pfam PF02687 FtsX-like permease family 685 794 1.8E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06005 0ef25f636e1162a404511abce0fd15e8 805 Pfam PF02687 FtsX-like permease family 294 408 4.0E-14 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06005 0ef25f636e1162a404511abce0fd15e8 805 PANTHER PTHR30572 405 805 1.4E-59 T 21-04-2016 SPH21_RS06005 0ef25f636e1162a404511abce0fd15e8 805 PANTHER PTHR30572 291 359 1.4E-59 T 21-04-2016 SPH21_RS18160 03043bce12c2ed80d45cfbd6d881ae06 478 SUPERFAMILY SSF48452 55 204 2.09E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 Gene3D G3DSA:3.40.50.720 5 250 3.2E-59 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 9.8E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 9.8E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 9.8E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 9.8E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 9.8E-19 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 21 249 6.2E-45 T 21-04-2016 SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PANTHER PTHR24322:SF456 13 142 1.5E-67 T 21-04-2016 SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PANTHER PTHR24322:SF456 158 190 1.5E-67 T 21-04-2016 SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 SUPERFAMILY SSF51735 7 250 4.14E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PANTHER PTHR24322 13 142 1.5E-67 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS00365 21bba037e60f35112cf1546cecef0382 251 PANTHER PTHR24322 158 190 1.5E-67 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05930 82da5d60aa54d3168bc6b2fb025dcbff 157 Pfam PF13673 Acetyltransferase (GNAT) domain 49 153 2.2E-17 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS05930 82da5d60aa54d3168bc6b2fb025dcbff 157 PANTHER PTHR23091 22 154 1.6E-31 T 21-04-2016 SPH21_RS05930 82da5d60aa54d3168bc6b2fb025dcbff 157 PANTHER PTHR23091:SF275 22 154 1.6E-31 T 21-04-2016 SPH21_RS05930 82da5d60aa54d3168bc6b2fb025dcbff 157 Gene3D G3DSA:3.40.630.30 15 152 8.2E-45 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS05930 82da5d60aa54d3168bc6b2fb025dcbff 157 SUPERFAMILY SSF55729 10 154 2.96E-35 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23965 421086d12d68b4f7a1a53527d95cee3e 324 Pfam PF16344 Domain of unknown function (DUF4974) 222 322 2.0E-27 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS23965 421086d12d68b4f7a1a53527d95cee3e 324 PIRSF PIRSF018266 1 324 8.0E-63 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS23965 421086d12d68b4f7a1a53527d95cee3e 324 PANTHER PTHR30273:SF2 7 323 6.4E-72 T 21-04-2016 SPH21_RS23965 421086d12d68b4f7a1a53527d95cee3e 324 Pfam PF04773 FecR protein 117 209 7.4E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS23965 421086d12d68b4f7a1a53527d95cee3e 324 PANTHER PTHR30273 7 323 6.4E-72 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS24410 89478199feb731b93ba6aecea2d8e95d 220 SUPERFAMILY SSF52172 4 139 1.99E-12 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS24410 89478199feb731b93ba6aecea2d8e95d 220 Pfam PF00072 Response regulator receiver domain 5 129 3.5E-9 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24410 89478199feb731b93ba6aecea2d8e95d 220 SMART SM00448 3 129 3.7E-4 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24410 89478199feb731b93ba6aecea2d8e95d 220 Gene3D G3DSA:3.40.50.2300 4 138 1.3E-15 T 21-04-2016 SPH21_RS20255 7050914d20907f31bee31afe16a1054c 237 SUPERFAMILY SSF52540 1 213 5.44E-59 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS20255 7050914d20907f31bee31afe16a1054c 237 PANTHER PTHR24220:SF0 1 230 9.2E-102 T 21-04-2016 SPH21_RS20255 7050914d20907f31bee31afe16a1054c 237 Pfam PF00005 ABC transporter 12 154 1.6E-26 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS20255 7050914d20907f31bee31afe16a1054c 237 SMART SM00382 20 210 4.1E-6 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS20255 7050914d20907f31bee31afe16a1054c 237 PANTHER PTHR24220 1 230 9.2E-102 T 21-04-2016 SPH21_RS20255 7050914d20907f31bee31afe16a1054c 237 Gene3D G3DSA:3.40.50.300 1 214 6.6E-66 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS22170 369ffb50f219ae337ee6df13ab0c1960 323 Pfam PF06439 Domain of Unknown Function (DUF1080) 152 319 1.3E-39 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 TIGRFAM TIGR01845 outer_NodT: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family 20 487 2.9E-85 T 21-04-2016 IPR010131 RND efflux system, outer membrane lipoprotein, NodT GO:0005215|GO:0006810|GO:0008289|GO:0016020 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 SUPERFAMILY SSF56954 11 487 3.4E-95 T 21-04-2016 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 PANTHER PTHR30203 1 487 1.3E-100 T 21-04-2016 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 Pfam PF02321 Outer membrane efflux protein 74 276 5.3E-25 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 Pfam PF02321 Outer membrane efflux protein 306 485 1.3E-28 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 PANTHER PTHR30203:SF14 1 487 1.3E-100 T 21-04-2016 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 Gene3D G3DSA:2.20.200.10 107 163 8.1E-7 T 21-04-2016 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 Gene3D G3DSA:2.20.200.10 336 371 8.1E-7 T 21-04-2016 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 Gene3D G3DSA:1.20.1600.10 61 97 2.5E-92 T 21-04-2016 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 Gene3D G3DSA:1.20.1600.10 164 335 2.5E-92 T 21-04-2016 SPH21_RS02080 33d3bcdaba07eb647727f1835333fd6a 488 Gene3D G3DSA:1.20.1600.10 374 487 2.5E-92 T 21-04-2016 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 Pfam PF00512 His Kinase A (phospho-acceptor) domain 116 183 1.4E-14 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 PRINTS PR00344 Bacterial sensor protein C-terminal signature 267 281 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 PRINTS PR00344 Bacterial sensor protein C-terminal signature 285 295 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 PRINTS PR00344 Bacterial sensor protein C-terminal signature 302 320 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 PRINTS PR00344 Bacterial sensor protein C-terminal signature 326 339 2.3E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 Gene3D G3DSA:1.10.287.130 107 168 4.1E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 231 339 3.9E-23 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 Gene3D G3DSA:3.30.565.10 169 339 3.7E-46 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 SMART SM00388 115 183 8.8E-15 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 SUPERFAMILY SSF47384 103 184 1.06E-18 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 SUPERFAMILY SSF55874 173 338 1.44E-45 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 PANTHER PTHR24423 94 338 1.1E-76 T 21-04-2016 SPH21_RS06740 3fb86d0b29475d7b2c78db36e7625ec1 341 SMART SM00387 230 341 1.5E-31 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS14190 9dcc9df26dcdf13cca7e73d361a6f026 338 Gene3D G3DSA:3.40.50.720 29 257 3.2E-12 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14190 9dcc9df26dcdf13cca7e73d361a6f026 338 SUPERFAMILY SSF51735 29 320 3.56E-26 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14190 9dcc9df26dcdf13cca7e73d361a6f026 338 Gene3D G3DSA:3.90.25.10 258 320 0.001 T 21-04-2016 SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PANTHER PTHR24322:SF608 155 186 1.5E-59 T 21-04-2016 SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PANTHER PTHR24322:SF608 11 139 1.5E-59 T 21-04-2016 SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 SUPERFAMILY SSF51735 5 248 1.73E-81 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 142 170 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PANTHER PTHR24322 155 186 1.5E-59 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PANTHER PTHR24322 11 139 1.5E-59 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 191 0.0056 T 21-04-2016 SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 Gene3D G3DSA:3.40.50.720 1 248 6.7E-84 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 2.0E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 2.0E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 2.0E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 3.5E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 3.5E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 3.5E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 3.5E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 3.5E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.5E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21585 c4c29ea2ef879d8a6191b36c24fd4c74 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 248 2.6E-63 T 21-04-2016 SPH21_RS02890 ba67f2e9e69647582d873072039c4d3d 346 SUPERFAMILY SSF50939 10 233 7.85E-21 T 21-04-2016 IPR011040 Sialidases SPH21_RS02890 ba67f2e9e69647582d873072039c4d3d 346 Gene3D G3DSA:2.120.10.10 8 336 1.0E-24 T 21-04-2016 IPR011040 Sialidases SPH21_RS02890 ba67f2e9e69647582d873072039c4d3d 346 Pfam PF13088 BNR repeat-like domain 93 169 8.4E-7 T 21-04-2016 IPR011040 Sialidases SPH21_RS00640 d6bb8a9d5871975f4b3c0efacf8b0219 334 Pfam PF06580 Histidine kinase 153 232 7.4E-21 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS00640 d6bb8a9d5871975f4b3c0efacf8b0219 334 PANTHER PTHR34220 6 323 1.4E-36 T 21-04-2016 SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 PANTHER PTHR30173 1 198 1.7E-46 T 21-04-2016 SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 SUPERFAMILY SSF88946 10 108 9.03E-26 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 25 179 7.2E-28 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 Gene3D G3DSA:1.10.10.10 122 182 1.4E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 SUPERFAMILY SSF88659 103 185 5.79E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 Pfam PF04542 Sigma-70 region 2 29 93 2.7E-15 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 Gene3D G3DSA:1.10.1740.10 9 119 3.6E-26 T 21-04-2016 SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 25 180 1.9E-40 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS21830 77c44b7a3312f12b82dc61f12fb89b5d 198 Pfam PF08281 Sigma-70, region 4 125 178 2.4E-15 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 PANTHER PTHR21371 1 491 2.1E-174 T 21-04-2016 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 Gene3D G3DSA:1.10.1040.10 364 484 7.7E-19 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 Pfam PF01450 Acetohydroxy acid isomeroreductase, catalytic domain 210 342 1.7E-30 T 21-04-2016 IPR000506 Acetohydroxy acid isomeroreductase C-terminal GO:0004455|GO:0009082|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 Pfam PF01450 Acetohydroxy acid isomeroreductase, catalytic domain 355 485 8.7E-21 T 21-04-2016 IPR000506 Acetohydroxy acid isomeroreductase C-terminal GO:0004455|GO:0009082|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 SUPERFAMILY SSF48179 348 487 1.56E-42 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 SUPERFAMILY SSF48179 210 370 4.08E-44 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 TIGRFAM TIGR00465 ilvC: ketol-acid reductoisomerase 35 358 5.3E-116 T 21-04-2016 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 Pfam PF07991 Acetohydroxy acid isomeroreductase, NADPH-binding domain 35 204 1.0E-56 T 21-04-2016 IPR013116 Acetohydroxy acid isomeroreductase, NADPH-binding domain KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 Hamap MF_00435 Ketol-acid reductoisomerase [ilvC]. 22 488 36.513 T 21-04-2016 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111|UniPathway: UPA00047|UniPathway: UPA00049 SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 SUPERFAMILY SSF51735 28 209 9.18E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11255 dc0808c5c94cc2ef6107cd565da05b5f 493 Gene3D G3DSA:3.40.50.720 1 201 2.9E-68 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24335 370d7d89a306fa3fc3c3a05fffbd890a 202 Pfam PF14279 HNH endonuclease 3 52 9.8E-11 T 21-04-2016 IPR029471 HNH endonuclease 5 SPH21_RS11380 4bf97185d907af4e7146db323061d448 553 PANTHER PTHR31683:SF9 80 222 3.6E-119 T 21-04-2016 SPH21_RS11380 4bf97185d907af4e7146db323061d448 553 PANTHER PTHR31683:SF9 238 414 3.6E-119 T 21-04-2016 SPH21_RS11380 4bf97185d907af4e7146db323061d448 553 PANTHER PTHR31683 80 222 3.6E-119 T 21-04-2016 SPH21_RS11380 4bf97185d907af4e7146db323061d448 553 PANTHER PTHR31683 238 414 3.6E-119 T 21-04-2016 SPH21_RS11380 4bf97185d907af4e7146db323061d448 553 Gene3D G3DSA:2.160.20.10 65 431 3.2E-51 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS11380 4bf97185d907af4e7146db323061d448 553 SUPERFAMILY SSF51126 361 433 2.24E-62 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS11380 4bf97185d907af4e7146db323061d448 553 SUPERFAMILY SSF51126 76 334 2.24E-62 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS23445 be7ba982456f00d62b9c5ddc08b320bb 172 Gene3D G3DSA:1.10.3820.10 27 69 2.1E-4 T 21-04-2016 SPH21_RS23445 be7ba982456f00d62b9c5ddc08b320bb 172 SUPERFAMILY SSF48695 28 94 1.05E-6 T 21-04-2016 IPR011031 Multihaem cytochrome SPH21_RS23445 be7ba982456f00d62b9c5ddc08b320bb 172 Gene3D G3DSA:1.10.760.10 70 123 4.3E-5 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS03065 90bd7e109bab92a8c16ad3e2a3f4cd2f 582 Gene3D G3DSA:1.25.40.10 401 516 5.1E-25 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03065 90bd7e109bab92a8c16ad3e2a3f4cd2f 582 Gene3D G3DSA:1.25.40.10 208 317 5.1E-25 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03065 90bd7e109bab92a8c16ad3e2a3f4cd2f 582 Pfam PF07980 SusD family 286 582 1.4E-30 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS03065 90bd7e109bab92a8c16ad3e2a3f4cd2f 582 Pfam PF14322 Starch-binding associating with outer membrane 91 229 4.3E-10 T 21-04-2016 SPH21_RS03065 90bd7e109bab92a8c16ad3e2a3f4cd2f 582 SUPERFAMILY SSF48452 18 472 8.35E-92 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03065 90bd7e109bab92a8c16ad3e2a3f4cd2f 582 SUPERFAMILY SSF48452 499 582 8.35E-92 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS20810 d264fc8901a9767ffbe11ef9044c28fc 298 SUPERFAMILY SSF50475 5 196 2.45E-40 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS20810 d264fc8901a9767ffbe11ef9044c28fc 298 Gene3D G3DSA:2.30.110.10 20 194 6.5E-55 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS20810 d264fc8901a9767ffbe11ef9044c28fc 298 PANTHER PTHR33798 1 226 5.2E-50 T 21-04-2016 SPH21_RS20810 d264fc8901a9767ffbe11ef9044c28fc 298 SMART SM00903 22 176 5.5E-10 T 21-04-2016 IPR002563 Flavin reductase like domain GO:0010181 SPH21_RS20810 d264fc8901a9767ffbe11ef9044c28fc 298 Pfam PF01613 Flavin reductase like domain 26 169 1.7E-12 T 21-04-2016 IPR002563 Flavin reductase like domain GO:0010181 SPH21_RS24865 e704666662041ccb9129cf153c01d722 124 Pfam PF13564 DoxX-like family 9 112 3.9E-16 T 21-04-2016 IPR032808 DoxX family SPH21_RS19195 64f7cb6319eaa3be70fe171fe7a261e7 407 Gene3D G3DSA:3.60.21.10 1 293 3.2E-60 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS19195 64f7cb6319eaa3be70fe171fe7a261e7 407 SUPERFAMILY SSF56300 1 313 5.17E-43 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS19195 64f7cb6319eaa3be70fe171fe7a261e7 407 TIGRFAM TIGR00619 sbcd: exonuclease SbcCD, D subunit 1 273 4.1E-54 T 21-04-2016 IPR004593 Nuclease SbcCD subunit D GO:0004519|GO:0006259|GO:0008408 SPH21_RS19195 64f7cb6319eaa3be70fe171fe7a261e7 407 PANTHER PTHR30337:SF0 1 289 2.4E-58 T 21-04-2016 SPH21_RS19195 64f7cb6319eaa3be70fe171fe7a261e7 407 Pfam PF00149 Calcineurin-like phosphoesterase 1 245 2.5E-13 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS19195 64f7cb6319eaa3be70fe171fe7a261e7 407 PANTHER PTHR30337 1 289 2.4E-58 T 21-04-2016 SPH21_RS11235 e4c57cb2d0961213895ef50b22aff736 198 PANTHER PTHR11670:SF27 5 192 3.5E-70 T 21-04-2016 SPH21_RS11235 e4c57cb2d0961213895ef50b22aff736 198 TIGRFAM TIGR00171 leuD: 3-isopropylmalate dehydratase, small subunit 5 180 4.1E-53 T 21-04-2016 IPR004431 3-isopropylmalate dehydratase, small subunit GO:0003861|GO:0009098|GO:0009316 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11235 e4c57cb2d0961213895ef50b22aff736 198 Gene3D G3DSA:3.20.19.10 4 182 1.2E-39 T 21-04-2016 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SPH21_RS11235 e4c57cb2d0961213895ef50b22aff736 198 SUPERFAMILY SSF52016 4 189 4.12E-50 T 21-04-2016 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SPH21_RS11235 e4c57cb2d0961213895ef50b22aff736 198 Pfam PF00694 Aconitase C-terminal domain 5 123 2.2E-30 T 21-04-2016 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11235 e4c57cb2d0961213895ef50b22aff736 198 PANTHER PTHR11670 5 192 3.5E-70 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS14335 9fa95d48797a305daa1a549ac9a26e0e 344 Pfam PF09492 Pectic acid lyase 39 332 9.3E-103 T 21-04-2016 IPR012669 Pectic acid lyase SPH21_RS14335 9fa95d48797a305daa1a549ac9a26e0e 344 Gene3D G3DSA:1.50.10.20 24 340 3.0E-113 T 21-04-2016 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SPH21_RS14335 9fa95d48797a305daa1a549ac9a26e0e 344 SUPERFAMILY SSF81853 15 339 2.49E-79 T 21-04-2016 SPH21_RS14335 9fa95d48797a305daa1a549ac9a26e0e 344 TIGRFAM TIGR02474 pec_lyase: pectate lyase 39 332 9.9E-98 T 21-04-2016 IPR012669 Pectic acid lyase SPH21_RS03310 8f582528bcaef4d5fdad818520c78bcc 433 TIGRFAM TIGR00908 2A0305: ethanolamine permease 2 425 3.2E-130 T 21-04-2016 IPR004757 Ethanolamine permease SPH21_RS03310 8f582528bcaef4d5fdad818520c78bcc 433 PANTHER PTHR11785 5 430 4.8E-101 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS03310 8f582528bcaef4d5fdad818520c78bcc 433 Pfam PF13520 Amino acid permease 10 411 7.9E-44 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS03310 8f582528bcaef4d5fdad818520c78bcc 433 PANTHER PTHR11785:SF337 5 430 4.8E-101 T 21-04-2016 SPH21_RS03310 8f582528bcaef4d5fdad818520c78bcc 433 PIRSF PIRSF006060 1 433 2.2E-72 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS16930 17ed1220ed35749cc35b5bb6954714cb 405 PANTHER PTHR34219 10 395 4.8E-59 T 21-04-2016 SPH21_RS16930 17ed1220ed35749cc35b5bb6954714cb 405 Pfam PF03929 PepSY-associated TM region 22 386 1.7E-66 T 21-04-2016 IPR005625 PepSY-associated TM protein SPH21_RS03290 dba06604bca5cbb51e5c06e2a09cd8d7 456 Pfam PF00171 Aldehyde dehydrogenase family 2 449 2.3E-129 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS03290 dba06604bca5cbb51e5c06e2a09cd8d7 456 PANTHER PTHR11699:SF65 1 452 2.4E-195 T 21-04-2016 SPH21_RS03290 dba06604bca5cbb51e5c06e2a09cd8d7 456 Gene3D G3DSA:3.40.309.10 239 424 1.1E-60 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS03290 dba06604bca5cbb51e5c06e2a09cd8d7 456 PANTHER PTHR11699 1 452 2.4E-195 T 21-04-2016 SPH21_RS03290 dba06604bca5cbb51e5c06e2a09cd8d7 456 SUPERFAMILY SSF53720 2 451 2.36E-132 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS03290 dba06604bca5cbb51e5c06e2a09cd8d7 456 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 225 232 - T 21-04-2016 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SPH21_RS03290 dba06604bca5cbb51e5c06e2a09cd8d7 456 Gene3D G3DSA:3.40.605.10 2 238 2.8E-62 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS22375 a8a7f378f2e5d0179c21f8182da2dd93 253 Pfam PF00005 ABC transporter 22 178 1.3E-27 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS22375 a8a7f378f2e5d0179c21f8182da2dd93 253 PANTHER PTHR24220:SF585 8 250 3.8E-106 T 21-04-2016 SPH21_RS22375 a8a7f378f2e5d0179c21f8182da2dd93 253 SUPERFAMILY SSF52540 5 239 4.28E-56 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS22375 a8a7f378f2e5d0179c21f8182da2dd93 253 PANTHER PTHR24220 8 250 3.8E-106 T 21-04-2016 SPH21_RS22375 a8a7f378f2e5d0179c21f8182da2dd93 253 Gene3D G3DSA:3.40.50.300 2 245 6.4E-63 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS22375 a8a7f378f2e5d0179c21f8182da2dd93 253 SMART SM00382 31 225 1.7E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 Gene3D G3DSA:1.10.287.130 1017 1081 1.3E-8 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1191 1201 3.9E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1173 1187 3.9E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1202 1220 3.9E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1226 1239 3.9E-16 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 Gene3D G3DSA:3.30.565.10 1082 1240 6.8E-37 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 SMART SM00387 1134 1240 6.8E-26 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 PANTHER PTHR24423:SF520 955 1240 1.9E-54 T 21-04-2016 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 Pfam PF00672 HAMP domain 945 1009 8.7E-9 T 21-04-2016 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1134 1240 6.3E-21 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 SMART SM00388 1023 1094 4.9E-7 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 SUPERFAMILY SSF55874 1088 1240 7.47E-37 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 PANTHER PTHR24423 955 1240 1.9E-54 T 21-04-2016 SPH21_RS06480 cfc42267f9b48af42af842e08e992a14 1240 SUPERFAMILY SSF47384 1016 1093 4.9E-9 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 Gene3D G3DSA:2.60.120.280 33 161 8.0E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 SUPERFAMILY SSF46689 234 279 4.93E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 262 278 3.9E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 247 262 3.9E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 SUPERFAMILY SSF51215 33 151 4.45E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 Gene3D G3DSA:1.10.10.60 233 279 8.3E-16 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 Pfam PF12833 Helix-turn-helix domain 203 279 2.4E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 SMART SM00342 195 278 2.7E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 PANTHER PTHR11019:SF45 13 279 4.3E-41 T 21-04-2016 SPH21_RS12405 49b47e828449256fcdf330f15af94ef1 283 PANTHER PTHR11019 13 279 4.3E-41 T 21-04-2016 SPH21_RS09530 245197d43d1df6e0f93d5b3128ed1423 486 SUPERFAMILY SSF48452 19 486 5.56E-115 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09530 245197d43d1df6e0f93d5b3128ed1423 486 Pfam PF14322 Starch-binding associating with outer membrane 23 222 5.4E-17 T 21-04-2016 SPH21_RS09530 245197d43d1df6e0f93d5b3128ed1423 486 Gene3D G3DSA:1.25.40.10 203 428 2.4E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09530 245197d43d1df6e0f93d5b3128ed1423 486 Pfam PF07980 SusD family 289 486 3.1E-38 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS15610 185e310ff4e0111682220031a2e7b86c 225 Hamap MF_00238 Cytidylate kinase [cmk]. 6 224 31.702 T 21-04-2016 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 SPH21_RS15610 185e310ff4e0111682220031a2e7b86c 225 Pfam PF02224 Cytidylate kinase 8 220 3.9E-70 T 21-04-2016 IPR011994 Cytidylate kinase domain GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 SPH21_RS15610 185e310ff4e0111682220031a2e7b86c 225 TIGRFAM TIGR00017 cmk: cytidylate kinase 5 219 2.0E-74 T 21-04-2016 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 SPH21_RS15610 185e310ff4e0111682220031a2e7b86c 225 SUPERFAMILY SSF52540 6 220 1.1E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15610 185e310ff4e0111682220031a2e7b86c 225 PANTHER PTHR21299 7 220 4.8E-63 T 21-04-2016 SPH21_RS15610 185e310ff4e0111682220031a2e7b86c 225 Gene3D G3DSA:3.40.50.300 4 220 5.4E-74 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 Gene3D G3DSA:3.90.110.10 146 302 2.8E-49 T 21-04-2016 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 TIGRFAM TIGR01763 MalateDH_bact: malate dehydrogenase, NAD-dependent 1 306 2.3E-106 T 21-04-2016 IPR011275 Malate dehydrogenase, type 3 GO:0016616|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PRINTS PR00086 L-lactate dehydrogenase signature 2 26 6.4E-32 T 21-04-2016 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PRINTS PR00086 L-lactate dehydrogenase signature 27 51 6.4E-32 T 21-04-2016 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PRINTS PR00086 L-lactate dehydrogenase signature 140 158 6.4E-32 T 21-04-2016 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PRINTS PR00086 L-lactate dehydrogenase signature 116 136 6.4E-32 T 21-04-2016 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PRINTS PR00086 L-lactate dehydrogenase signature 170 183 6.4E-32 T 21-04-2016 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 Hamap MF_00487 Malate dehydrogenase [mdh]. 1 307 38.283 T 21-04-2016 IPR011275 Malate dehydrogenase, type 3 GO:0016616|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 Pfam PF00056 lactate/malate dehydrogenase, NAD binding domain 1 142 3.0E-41 T 21-04-2016 IPR001236 Lactate/malate dehydrogenase, N-terminal GO:0016491|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 SUPERFAMILY SSF51735 1 143 1.11E-45 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 SUPERFAMILY SSF56327 143 305 5.77E-44 T 21-04-2016 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 Gene3D G3DSA:3.40.50.720 1 144 4.9E-52 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PANTHER PTHR11540:SF16 1 302 3.2E-109 T 21-04-2016 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PANTHER PTHR11540 1 302 3.2E-109 T 21-04-2016 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 PIRSF PIRSF000102 1 311 1.0E-99 T 21-04-2016 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SPH21_RS19530 499ecbad00424649dcf74b9a092b7eea 312 Pfam PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 147 301 2.4E-26 T 21-04-2016 IPR022383 Lactate/malate dehydrogenase, C-terminal GO:0016616|GO:0055114 SPH21_RS08265 cad46a0368c5a1073dbcca9631a6e8c7 182 PANTHER PTHR33885 1 66 7.7E-20 T 21-04-2016 SPH21_RS08265 cad46a0368c5a1073dbcca9631a6e8c7 182 Pfam PF04024 PspC domain 3 64 1.4E-20 T 21-04-2016 IPR007168 Phage shock protein, PspC, N-terminal SPH21_RS06410 e3dfc8cabd62f8755e10b866b29120a1 128 SUPERFAMILY SSF110069 5 123 2.35E-46 T 21-04-2016 IPR007474 ApaG domain SPH21_RS06410 e3dfc8cabd62f8755e10b866b29120a1 128 Pfam PF04379 Protein of unknown function (DUF525) 20 104 2.2E-35 T 21-04-2016 IPR007474 ApaG domain SPH21_RS06410 e3dfc8cabd62f8755e10b866b29120a1 128 PANTHER PTHR14289 6 119 2.8E-46 T 21-04-2016 SPH21_RS06410 e3dfc8cabd62f8755e10b866b29120a1 128 Gene3D G3DSA:2.60.40.1470 3 123 2.8E-46 T 21-04-2016 IPR007474 ApaG domain SPH21_RS24325 8d688efd99f6aa36299c74c9b263dd26 181 Pfam PF13207 AAA domain 12 130 6.6E-15 T 21-04-2016 SPH21_RS24325 8d688efd99f6aa36299c74c9b263dd26 181 SUPERFAMILY SSF52540 7 145 1.14E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24325 8d688efd99f6aa36299c74c9b263dd26 181 Gene3D G3DSA:3.40.50.300 7 126 1.1E-9 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15705 2362f682bb49190edb4a5e2dfd968530 178 Gene3D G3DSA:3.40.50.150 1 176 4.0E-44 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS15705 2362f682bb49190edb4a5e2dfd968530 178 PANTHER PTHR18895:SF60 1 166 6.2E-25 T 21-04-2016 SPH21_RS15705 2362f682bb49190edb4a5e2dfd968530 178 Pfam PF03602 Conserved hypothetical protein 95 1 175 5.7E-35 T 21-04-2016 SPH21_RS15705 2362f682bb49190edb4a5e2dfd968530 178 PIRSF PIRSF004553 1 178 2.2E-37 T 21-04-2016 IPR004398 RNA methyltransferase, RsmD GO:0008168|GO:0031167 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS15705 2362f682bb49190edb4a5e2dfd968530 178 SUPERFAMILY SSF53335 1 175 2.08E-37 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS15705 2362f682bb49190edb4a5e2dfd968530 178 PANTHER PTHR18895 1 166 6.2E-25 T 21-04-2016 SPH21_RS15705 2362f682bb49190edb4a5e2dfd968530 178 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 115 121 - T 21-04-2016 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 43 474 2.6E-62 T 21-04-2016 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 PANTHER PTHR30023:SF0 51 473 7.8E-49 T 21-04-2016 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 Gene3D G3DSA:3.40.710.10 49 93 6.5E-6 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 Gene3D G3DSA:3.40.710.10 268 476 1.5E-36 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 PANTHER PTHR30023 51 473 7.8E-49 T 21-04-2016 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 SUPERFAMILY SSF56601 36 476 9.9E-69 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 315 337 4.1E-15 T 21-04-2016 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 373 387 4.1E-15 T 21-04-2016 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 73 92 4.1E-15 T 21-04-2016 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 388 402 4.1E-15 T 21-04-2016 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SPH21_RS05270 00fb5c8645ad896a74bef3e247e0a08d 477 TIGRFAM TIGR00666 PBP4: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase 60 457 6.6E-52 T 21-04-2016 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 SUPERFAMILY SSF51445 24 367 2.53E-114 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PANTHER PTHR10030 4 459 1.1E-158 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 Pfam PF01120 Alpha-L-fucosidase 16 364 4.8E-119 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 Gene3D G3DSA:3.20.20.80 22 367 9.1E-124 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 Pfam PF16757 Alpha-L-fucosidase C-terminal domain 383 457 1.6E-6 T 21-04-2016 IPR031919 Alpha-L-fucosidase, C-terminal KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PIRSF PIRSF001092 2 447 1.0E-126 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PRINTS PR00741 Glycosyl hydrolase family 29 signature 90 105 7.1E-56 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PRINTS PR00741 Glycosyl hydrolase family 29 signature 317 338 7.1E-56 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PRINTS PR00741 Glycosyl hydrolase family 29 signature 350 372 7.1E-56 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PRINTS PR00741 Glycosyl hydrolase family 29 signature 238 259 7.1E-56 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PRINTS PR00741 Glycosyl hydrolase family 29 signature 129 145 7.1E-56 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PRINTS PR00741 Glycosyl hydrolase family 29 signature 148 166 7.1E-56 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 PRINTS PR00741 Glycosyl hydrolase family 29 signature 210 226 7.1E-56 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS08745 2907f788654ff0c30bad6e74f2970f92 461 SMART SM00812 23 410 9.8E-179 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS05575 e118b820aeeb86466856d0904134c48b 250 PANTHER PTHR33969 4 232 1.5E-45 T 21-04-2016 SPH21_RS05575 e118b820aeeb86466856d0904134c48b 250 Pfam PF02616 Segregation and condensation protein ScpA 24 233 2.9E-28 T 21-04-2016 IPR003768 Segregation and condensation protein A SPH21_RS05575 e118b820aeeb86466856d0904134c48b 250 PANTHER PTHR33969:SF2 4 232 1.5E-45 T 21-04-2016 SPH21_RS20940 ab982376ade2ee0836f4d0608c95bdfa 130 Pfam PF01042 Endoribonuclease L-PSP 15 129 3.4E-16 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS20940 ab982376ade2ee0836f4d0608c95bdfa 130 SUPERFAMILY SSF55298 1 130 1.16E-20 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS20940 ab982376ade2ee0836f4d0608c95bdfa 130 Gene3D G3DSA:3.30.1330.40 2 130 1.0E-23 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS17585 2de69513ac73031863e7a6476d2d4f2a 110 SUPERFAMILY SSF159894 6 102 3.14E-17 T 21-04-2016 SPH21_RS17585 2de69513ac73031863e7a6476d2d4f2a 110 Gene3D G3DSA:3.30.1460.30 7 101 1.2E-10 T 21-04-2016 IPR007076 TfoX, N-terminal SPH21_RS17585 2de69513ac73031863e7a6476d2d4f2a 110 Pfam PF04993 TfoX N-terminal domain 14 102 2.2E-20 T 21-04-2016 IPR007076 TfoX, N-terminal SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 80 91 6.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 133 141 6.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 172 6.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 127 143 7.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 91 7.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 7.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 153 172 7.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 191 7.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 197 217 7.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 140 168 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 Gene3D G3DSA:3.40.50.720 2 218 3.9E-55 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 Pfam PF00106 short chain dehydrogenase 3 190 1.3E-42 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 SUPERFAMILY SSF51735 3 216 2.61E-53 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PANTHER PTHR24322 153 184 3.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS08260 c5dc9a8c6e0c93bec5c9787be8e4adc3 235 PANTHER PTHR24322 7 137 3.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20500 046e6df580c3a1eb7126e291f1fdeadd 100 PANTHER PTHR33154 5 100 1.4E-21 T 21-04-2016 SPH21_RS20500 046e6df580c3a1eb7126e291f1fdeadd 100 Gene3D G3DSA:1.10.10.10 3 97 4.6E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20500 046e6df580c3a1eb7126e291f1fdeadd 100 SUPERFAMILY SSF46785 2 96 6.83E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20500 046e6df580c3a1eb7126e291f1fdeadd 100 Pfam PF12840 Helix-turn-helix domain 5 78 5.4E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20500 046e6df580c3a1eb7126e291f1fdeadd 100 SMART SM00418 5 97 6.6E-13 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS01920 dd4242565efdcd6bc4d319b5adb5b458 521 SUPERFAMILY SSF48452 17 520 1.26E-116 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS01920 dd4242565efdcd6bc4d319b5adb5b458 521 Pfam PF07980 SusD family 282 520 3.1E-40 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS01920 dd4242565efdcd6bc4d319b5adb5b458 521 Pfam PF14322 Starch-binding associating with outer membrane 101 228 6.8E-24 T 21-04-2016 SPH21_RS01920 dd4242565efdcd6bc4d319b5adb5b458 521 Gene3D G3DSA:1.25.40.10 209 326 4.0E-39 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS01920 dd4242565efdcd6bc4d319b5adb5b458 521 Gene3D G3DSA:1.25.40.10 373 462 4.0E-39 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PANTHER PTHR11686 35 568 1.3E-204 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 SUPERFAMILY SSF56235 35 568 2.89E-181 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 ProSitePatterns PS00462 Gamma-glutamyltranspeptidase signature. 379 403 - T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 TIGRFAM TIGR00066 g_glut_trans: gamma-glutamyltransferase 38 560 1.0E-175 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 151 170 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 249 265 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 468 485 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 133 151 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 444 459 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 60 85 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 379 397 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 279 298 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 403 421 1.2E-73 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 Pfam PF01019 Gamma-glutamyltranspeptidase 53 562 6.9E-170 T 21-04-2016 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SPH21_RS19260 c1faf71e0fe3bf8a2f6c80d9f0fbf308 568 PANTHER PTHR11686:SF9 35 568 1.3E-204 T 21-04-2016 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 TIGRFAM TIGR01087 murD: UDP-N-acetylmuramoylalanine--D-glutamate ligase 16 455 2.0E-123 T 21-04-2016 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 Pfam PF08245 Mur ligase middle domain 118 298 3.5E-34 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 PANTHER PTHR23135 1 457 1.2E-145 T 21-04-2016 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 Gene3D G3DSA:3.40.50.720 16 101 2.5E-11 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 Gene3D G3DSA:3.90.190.20 320 454 5.0E-48 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 PANTHER PTHR23135:SF2 1 457 1.2E-145 T 21-04-2016 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 Gene3D G3DSA:3.40.1190.10 102 316 6.3E-56 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 SUPERFAMILY SSF53623 104 316 4.45E-48 T 21-04-2016 IPR013221 Mur ligase, central GO:0005524|GO:0009058 UniPathway: UPA00219 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 Hamap MF_00639 UDP-N-acetylmuramoylalanine--D-glutamate ligase [murD]. 13 457 31.967 T 21-04-2016 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387|UniPathway: UPA00219 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 Pfam PF02875 Mur ligase family, glutamate ligase domain 319 393 6.1E-7 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 SUPERFAMILY SSF51984 16 101 2.88E-12 T 21-04-2016 SPH21_RS00285 a404a400fcf6aca938903007891c8a00 457 SUPERFAMILY SSF53244 319 457 2.93E-44 T 21-04-2016 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 UniPathway: UPA00219 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 434 659 6.0E-71 T 21-04-2016 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 800 976 2.3E-46 T 21-04-2016 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 Pfam PF07549 SecD/SecF GG Motif 714 741 5.5E-10 T 21-04-2016 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 TIGRFAM TIGR01129 secD: protein-export membrane protein SecD 78 665 1.0E-125 T 21-04-2016 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PANTHER PTHR30081 177 236 1.5E-116 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PANTHER PTHR30081 392 667 1.5E-116 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PANTHER PTHR30081 76 129 1.5E-116 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 Hamap MF_01463_B Protein translocase subunit SecD [secD]. 1 682 37.471 T 21-04-2016 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 Pfam PF02355 Protein export membrane protein 798 987 6.5E-57 T 21-04-2016 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 Pfam PF02355 Protein export membrane protein 499 671 8.4E-20 T 21-04-2016 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 Hamap MF_01464_B Protein-export membrane protein SecF [secF]. 692 990 27.147 T 21-04-2016 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PRINTS PR01755 Bacterial translocase SecF protein signature 927 942 3.6E-19 T 21-04-2016 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PRINTS PR01755 Bacterial translocase SecF protein signature 719 734 3.6E-19 T 21-04-2016 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PRINTS PR01755 Bacterial translocase SecF protein signature 893 911 3.6E-19 T 21-04-2016 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PANTHER PTHR30081:SF1 177 236 1.5E-116 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PANTHER PTHR30081:SF1 392 667 1.5E-116 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 PANTHER PTHR30081:SF1 76 129 1.5E-116 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 SUPERFAMILY SSF82866 767 986 9.29E-37 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 TIGRFAM TIGR00966 3a0501s07: protein-export membrane protein SecF 720 979 8.0E-68 T 21-04-2016 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 Gene3D G3DSA:1.20.1640.10 479 673 1.1E-27 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 Gene3D G3DSA:1.20.1640.10 777 985 1.4E-28 T 21-04-2016 SPH21_RS14790 ae24dc21deb4394184ee773235ecb9dc 1010 SUPERFAMILY SSF82866 476 672 1.29E-44 T 21-04-2016 SPH21_RS16390 7d8ffe950c5460ca2176e2ce637b3509 449 PANTHER PTHR22604:SF2 26 265 2.6E-89 T 21-04-2016 SPH21_RS16390 7d8ffe950c5460ca2176e2ce637b3509 449 PANTHER PTHR22604:SF2 283 437 2.6E-89 T 21-04-2016 SPH21_RS16390 7d8ffe950c5460ca2176e2ce637b3509 449 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 33 158 1.7E-12 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS16390 7d8ffe950c5460ca2176e2ce637b3509 449 Gene3D G3DSA:3.40.50.720 28 185 5.3E-37 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS16390 7d8ffe950c5460ca2176e2ce637b3509 449 SUPERFAMILY SSF51735 21 191 7.23E-33 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS16390 7d8ffe950c5460ca2176e2ce637b3509 449 PANTHER PTHR22604 26 265 2.6E-89 T 21-04-2016 SPH21_RS16390 7d8ffe950c5460ca2176e2ce637b3509 449 PANTHER PTHR22604 283 437 2.6E-89 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 60 986 2.9E-130 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532:SF57 67 136 1.2E-102 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532:SF57 157 391 1.2E-102 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532:SF57 516 985 1.2E-102 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532:SF57 446 499 1.2E-102 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 Pfam PF07715 TonB-dependent Receptor Plug Domain 67 190 5.7E-11 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 SUPERFAMILY SSF56935 794 855 4.58E-58 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 SUPERFAMILY SSF56935 67 217 4.58E-58 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 SUPERFAMILY SSF56935 899 986 4.58E-58 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 SUPERFAMILY SSF56935 635 738 4.58E-58 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 SUPERFAMILY SSF56935 280 603 4.58E-58 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 Gene3D G3DSA:2.170.130.10 67 197 1.2E-13 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532 67 136 1.2E-102 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532 157 391 1.2E-102 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532 516 985 1.2E-102 T 21-04-2016 SPH21_RS13660 81c21e0c4afd7d353bbf04e047a2c850 987 PANTHER PTHR11532 446 499 1.2E-102 T 21-04-2016 SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 Pfam PF01261 Xylose isomerase-like TIM barrel 29 279 1.9E-34 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 Pfam PF07582 AP endonuclease family 2 C terminus 280 334 1.5E-20 T 21-04-2016 IPR011418 AP endonuclease, family 2, C-terminal SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 SUPERFAMILY SSF51658 8 322 3.45E-61 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 PANTHER PTHR12110 99 338 8.0E-27 T 21-04-2016 SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 PANTHER PTHR12110 8 80 8.0E-27 T 21-04-2016 SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 PANTHER PTHR12110:SF17 99 338 8.0E-27 T 21-04-2016 SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 PANTHER PTHR12110:SF17 8 80 8.0E-27 T 21-04-2016 SPH21_RS19670 c1664b1d4fb605e60353733b17795de9 352 Gene3D G3DSA:3.20.20.150 9 324 2.5E-71 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS19225 93a566b7b6b8fcd93710fdacd04f254b 270 Gene3D G3DSA:1.20.910.10 7 254 2.6E-9 T 21-04-2016 IPR016084 Haem oxygenase-like, multi-helical Reactome: REACT_9431 SPH21_RS19225 93a566b7b6b8fcd93710fdacd04f254b 270 Pfam PF11251 Protein of unknown function (DUF3050) 21 249 7.9E-100 T 21-04-2016 IPR024423 Protein of unknown function DUF3050 SPH21_RS19225 93a566b7b6b8fcd93710fdacd04f254b 270 SUPERFAMILY SSF48613 5 251 1.96E-9 T 21-04-2016 IPR016084 Haem oxygenase-like, multi-helical Reactome: REACT_9431 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 SUPERFAMILY SSF48452 56 244 8.73E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 SUPERFAMILY SSF48452 236 368 1.57E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 SUPERFAMILY SSF55874 527 658 1.44E-18 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 Pfam PF07730 Histidine kinase 466 530 3.0E-13 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 Gene3D G3DSA:3.30.565.10 543 660 1.5E-15 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 PANTHER PTHR24421 436 661 7.9E-40 T 21-04-2016 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 Gene3D G3DSA:1.25.40.10 102 114 1.8E-12 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 Gene3D G3DSA:1.25.40.10 154 387 1.8E-12 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 SMART SM00387 568 661 2.4E-4 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 PANTHER PTHR24421:SF1 436 661 7.9E-40 T 21-04-2016 SPH21_RS21235 a53bac67d728bf671abe39aeaafb0a46 661 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 571 658 3.9E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS09360 56d0029dec50d44b7328faee7ff57abc 123 Pfam PF09431 Protein of unknown function (DUF2013) 19 82 3.5E-5 T 21-04-2016 IPR018556 Domain of unknown function DUF2013 SPH21_RS09360 56d0029dec50d44b7328faee7ff57abc 123 Gene3D G3DSA:1.10.10.10 7 64 3.2E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14840 00af01266a0de367992fd23249628aed 217 PANTHER PTHR30071 40 208 3.7E-25 T 21-04-2016 SPH21_RS14840 00af01266a0de367992fd23249628aed 217 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature 27 44 1.7E-6 T 21-04-2016 IPR003557 Cytochrome c-type biogenesis protein CcmC GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS14840 00af01266a0de367992fd23249628aed 217 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature 44 64 1.7E-6 T 21-04-2016 IPR003557 Cytochrome c-type biogenesis protein CcmC GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS14840 00af01266a0de367992fd23249628aed 217 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature 82 102 1.7E-6 T 21-04-2016 IPR003557 Cytochrome c-type biogenesis protein CcmC GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS14840 00af01266a0de367992fd23249628aed 217 PRINTS PR01386 Cytochrome c-type biogenesis protein CcmC signature 103 123 1.7E-6 T 21-04-2016 IPR003557 Cytochrome c-type biogenesis protein CcmC GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS14840 00af01266a0de367992fd23249628aed 217 Pfam PF01578 Cytochrome C assembly protein 38 159 3.3E-17 T 21-04-2016 IPR002541 Cytochrome c assembly protein GO:0017004|GO:0020037 SPH21_RS25815 c1c00dfa1c7e0889558b73bf5c823616 254 SUPERFAMILY SSF69618 12 249 4.71E-41 T 21-04-2016 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS25815 c1c00dfa1c7e0889558b73bf5c823616 254 Gene3D G3DSA:3.40.50.10090 17 137 4.0E-15 T 21-04-2016 SPH21_RS25815 c1c00dfa1c7e0889558b73bf5c823616 254 Gene3D G3DSA:3.40.50.10090 142 252 4.1E-19 T 21-04-2016 SPH21_RS25815 c1c00dfa1c7e0889558b73bf5c823616 254 PANTHER PTHR12390 4 254 1.5E-23 T 21-04-2016 SPH21_RS25815 c1c00dfa1c7e0889558b73bf5c823616 254 Pfam PF02602 Uroporphyrinogen-III synthase HemD 39 242 1.3E-32 T 21-04-2016 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|UniPathway: UPA00251 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 Hamap MF_00253_B Glycine--tRNA ligase [glyQS]. 5 479 46.523 T 21-04-2016 IPR022961 Glycine-tRNA ligase, bacterial GO:0004820 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 Gene3D G3DSA:3.40.50.800 383 475 6.8E-37 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 SUPERFAMILY SSF52954 374 477 1.96E-30 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 SUPERFAMILY SSF55681 9 390 5.57E-113 T 21-04-2016 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 Pfam PF03129 Anticodon binding domain 387 474 1.3E-17 T 21-04-2016 IPR004154 Anticodon-binding SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 TIGRFAM TIGR00389 glyS_dimeric: glycine--tRNA ligase 10 263 3.1E-89 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 180 356 1.1E-8 T 21-04-2016 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PRINTS PR01043 Glycyl-tRNA synthetase signature 185 202 3.0E-48 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PRINTS PR01043 Glycyl-tRNA synthetase signature 27 41 3.0E-48 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PRINTS PR01043 Glycyl-tRNA synthetase signature 234 244 3.0E-48 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PRINTS PR01043 Glycyl-tRNA synthetase signature 339 351 3.0E-48 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PRINTS PR01043 Glycyl-tRNA synthetase signature 424 443 3.0E-48 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PRINTS PR01043 Glycyl-tRNA synthetase signature 164 176 3.0E-48 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PRINTS PR01043 Glycyl-tRNA synthetase signature 217 234 3.0E-48 T 21-04-2016 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 Gene3D G3DSA:3.30.930.10 10 93 8.9E-144 T 21-04-2016 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 Gene3D G3DSA:3.30.930.10 150 382 8.9E-144 T 21-04-2016 SPH21_RS08450 19372a9ee905b27bce02febc26ac5818 488 PANTHER PTHR10745 11 479 4.0E-197 T 21-04-2016 IPR027031 Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 KEGG: 00970+6.1.1.14 SPH21_RS20510 a1f9f3715d6a5288534d3e1fc2ff4d63 193 PANTHER PTHR42637 1 192 9.4E-29 T 21-04-2016 SPH21_RS20510 a1f9f3715d6a5288534d3e1fc2ff4d63 193 PANTHER PTHR42637:SF1 1 192 9.4E-29 T 21-04-2016 SPH21_RS20510 a1f9f3715d6a5288534d3e1fc2ff4d63 193 Pfam PF06175 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) 44 192 4.4E-33 T 21-04-2016 IPR010386 tRNA-hydroxylase MiaE KEGG: 00231+1.-.-.-|KEGG: 00592+1.-.-.-|KEGG: 00633+1.-.-.-|KEGG: 00780+1.-.-.-|KEGG: 00860+1.-.-.-|KEGG: 00950+1.-.-.-|KEGG: 00981+1.-.-.-|UniPathway: UPA00729 SPH21_RS20510 a1f9f3715d6a5288534d3e1fc2ff4d63 193 Gene3D G3DSA:1.20.1260.10 3 193 5.3E-66 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS20510 a1f9f3715d6a5288534d3e1fc2ff4d63 193 PIRSF PIRSF020736 3 193 1.6E-51 T 21-04-2016 IPR010386 tRNA-hydroxylase MiaE KEGG: 00231+1.-.-.-|KEGG: 00592+1.-.-.-|KEGG: 00633+1.-.-.-|KEGG: 00780+1.-.-.-|KEGG: 00860+1.-.-.-|KEGG: 00950+1.-.-.-|KEGG: 00981+1.-.-.-|UniPathway: UPA00729 SPH21_RS20510 a1f9f3715d6a5288534d3e1fc2ff4d63 193 SUPERFAMILY SSF47240 2 193 1.22E-67 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 Gene3D G3DSA:2.40.50.40 146 212 1.1E-14 T 21-04-2016 SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 PANTHER PTHR26402 1 114 1.6E-22 T 21-04-2016 SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 SMART SM00850 154 254 7.3E-24 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 Pfam PF04397 LytTr DNA-binding domain 155 253 4.8E-17 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 Gene3D G3DSA:3.40.50.2300 1 119 1.6E-22 T 21-04-2016 SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 SUPERFAMILY SSF52172 1 132 7.54E-24 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 SMART SM00448 1 111 4.4E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS04295 d405018acd32e1b41ab0a0a001a2360f 255 Pfam PF00072 Response regulator receiver domain 3 108 1.4E-14 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS15460 49ab7debfdd0f4b5e51bcc41452036f3 362 PANTHER PTHR10681 220 345 2.4E-27 T 21-04-2016 SPH21_RS15460 49ab7debfdd0f4b5e51bcc41452036f3 362 Pfam PF14289 Domain of unknown function (DUF4369) 14 108 7.2E-9 T 21-04-2016 IPR025380 Domain of unknown function DUF4369 SPH21_RS15460 49ab7debfdd0f4b5e51bcc41452036f3 362 Gene3D G3DSA:3.40.30.10 223 359 2.9E-55 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS15460 49ab7debfdd0f4b5e51bcc41452036f3 362 SUPERFAMILY SSF52833 224 355 4.36E-36 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS15460 49ab7debfdd0f4b5e51bcc41452036f3 362 Pfam PF00578 AhpC/TSA family 227 346 8.9E-29 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS15460 49ab7debfdd0f4b5e51bcc41452036f3 362 ProSitePatterns PS00194 Thioredoxin family active site. 255 273 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS21000 be43640065e89007e4cf4173e2d0120f 435 Gene3D G3DSA:1.50.10.10 53 391 6.1E-9 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS21000 be43640065e89007e4cf4173e2d0120f 435 SUPERFAMILY SSF48208 54 414 1.16E-34 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS00395 0ce72c59405dd0fbd901c20d01c9ef1b 397 Gene3D G3DSA:2.30.42.10 316 384 3.1E-13 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS00395 0ce72c59405dd0fbd901c20d01c9ef1b 397 SUPERFAMILY SSF50630 51 176 4.03E-6 T 21-04-2016 IPR021109 Aspartic peptidase domain SPH21_RS00395 0ce72c59405dd0fbd901c20d01c9ef1b 397 SUPERFAMILY SSF50156 312 393 8.15E-14 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS00395 0ce72c59405dd0fbd901c20d01c9ef1b 397 Pfam PF13650 Aspartyl protease 194 282 3.4E-7 T 21-04-2016 SPH21_RS00395 0ce72c59405dd0fbd901c20d01c9ef1b 397 Pfam PF13650 Aspartyl protease 46 140 4.4E-11 T 21-04-2016 SPH21_RS00395 0ce72c59405dd0fbd901c20d01c9ef1b 397 SMART SM00228 315 381 2.1E-9 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS00395 0ce72c59405dd0fbd901c20d01c9ef1b 397 Pfam PF00595 PDZ domain (Also known as DHR or GLGF) 323 377 1.0E-6 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 SUPERFAMILY SSF51735 137 296 8.02E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 PANTHER PTHR11695 12 338 1.1E-86 T 21-04-2016 IPR002085 Alcohol dehydrogenase superfamily, zinc-type GO:0008270|GO:0016491|GO:0055114 SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 SUPERFAMILY SSF50129 1 166 1.89E-41 T 21-04-2016 IPR011032 GroES-like SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 Gene3D G3DSA:3.90.180.10 1 160 3.9E-44 T 21-04-2016 IPR011032 GroES-like SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 Gene3D G3DSA:3.40.50.720 161 281 2.2E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 129 6.5E-30 T 21-04-2016 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 Pfam PF00107 Zinc-binding dehydrogenase 169 296 9.1E-19 T 21-04-2016 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SPH21_RS19080 ee87dd0208082563316bbf719b288971 339 PANTHER PTHR11695:SF38 12 338 1.1E-86 T 21-04-2016 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 Pfam PF07715 TonB-dependent Receptor Plug Domain 129 225 1.4E-8 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 PANTHER PTHR30069 5 270 1.9E-33 T 21-04-2016 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 PANTHER PTHR30069:SF11 5 270 1.9E-33 T 21-04-2016 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 Gene3D G3DSA:2.170.130.10 128 234 1.9E-9 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 SUPERFAMILY SSF56935 99 251 1.59E-69 T 21-04-2016 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 SUPERFAMILY SSF56935 299 907 1.59E-69 T 21-04-2016 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 Pfam PF13715 CarboxypepD_reg-like domain 26 113 2.9E-22 T 21-04-2016 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 Gene3D G3DSA:2.60.40.1120 26 115 1.6E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 Gene3D G3DSA:2.40.170.20 235 258 2.7E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 Gene3D G3DSA:2.40.170.20 304 907 2.7E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS19570 c159e53c92748f33eab8cc96edef8fd6 910 SUPERFAMILY SSF49464 24 111 4.71E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS24055 501176f81e7251c974a6b6ef6e73da43 261 Pfam PF05726 Pirin C-terminal cupin domain 140 246 1.1E-11 T 21-04-2016 IPR008778 Pirin, C-terminal domain SPH21_RS24055 501176f81e7251c974a6b6ef6e73da43 261 Gene3D G3DSA:2.60.120.10 1 218 3.4E-29 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS24055 501176f81e7251c974a6b6ef6e73da43 261 PIRSF PIRSF006232 1 254 5.6E-30 T 21-04-2016 IPR012093 Pirin SPH21_RS24055 501176f81e7251c974a6b6ef6e73da43 261 PANTHER PTHR13903 19 261 3.5E-22 T 21-04-2016 IPR012093 Pirin SPH21_RS24055 501176f81e7251c974a6b6ef6e73da43 261 SUPERFAMILY SSF51182 2 256 1.78E-27 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS04325 d8e51004445fcf7be1e6f46546cbb4cb 303 SUPERFAMILY SSF51735 6 255 5.57E-23 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04325 d8e51004445fcf7be1e6f46546cbb4cb 303 PANTHER PTHR14194 1 298 7.9E-65 T 21-04-2016 SPH21_RS04325 d8e51004445fcf7be1e6f46546cbb4cb 303 PANTHER PTHR14194:SF49 1 298 7.9E-65 T 21-04-2016 SPH21_RS04325 d8e51004445fcf7be1e6f46546cbb4cb 303 Gene3D G3DSA:3.40.50.720 5 188 1.7E-13 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04325 d8e51004445fcf7be1e6f46546cbb4cb 303 Pfam PF05368 NmrA-like family 8 234 5.2E-14 T 21-04-2016 IPR008030 NmrA-like domain SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 Pfam PF03781 Sulfatase-modifying factor enzyme 1 43 423 1.1E-50 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 PANTHER PTHR23150:SF19 44 146 2.7E-36 T 21-04-2016 SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 PANTHER PTHR23150:SF19 225 257 2.7E-36 T 21-04-2016 SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 PANTHER PTHR23150:SF19 275 425 2.7E-36 T 21-04-2016 SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 SUPERFAMILY SSF56436 42 94 1.53E-60 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 SUPERFAMILY SSF56436 185 425 1.53E-60 T 21-04-2016 IPR016187 C-type lectin fold SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 Gene3D G3DSA:3.90.1580.10 34 96 7.8E-85 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 Gene3D G3DSA:3.90.1580.10 179 425 7.8E-85 T 21-04-2016 IPR005532 Sulfatase-modifying factor enzyme SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 PANTHER PTHR23150 44 146 2.7E-36 T 21-04-2016 SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 PANTHER PTHR23150 225 257 2.7E-36 T 21-04-2016 SPH21_RS25810 d71e9cb54761e5ed85bcf45de8eade32 431 PANTHER PTHR23150 275 425 2.7E-36 T 21-04-2016 SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 PANTHER PTHR21235 4 193 2.0E-64 T 21-04-2016 SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 Hamap MF_00278 Imidazole glycerol phosphate synthase subunit HisH [hisH]. 1 196 31.368 T 21-04-2016 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 UniPathway: UPA00031 SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 TIGRFAM TIGR01855 IMP_synth_hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit 2 195 2.6E-62 T 21-04-2016 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 UniPathway: UPA00031 SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 PIRSF PIRSF000495 1 196 1.3E-60 T 21-04-2016 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 UniPathway: UPA00031 SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 SUPERFAMILY SSF52317 2 194 9.03E-48 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 Gene3D G3DSA:3.40.50.880 1 195 4.3E-63 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 PANTHER PTHR21235:SF1 4 193 2.0E-64 T 21-04-2016 SPH21_RS25325 d80f2a7bc0313af9ff0a893d7d109ad7 196 Pfam PF00117 Glutamine amidotransferase class-I 37 194 1.9E-18 T 21-04-2016 IPR017926 Glutamine amidotransferase Reactome: REACT_1698 SPH21_RS12195 6c0a902c8d50ac5fe84e23ee0f61eb9a 335 TIGRFAM TIGR01128 holA: DNA polymerase III, delta subunit 15 332 7.2E-53 T 21-04-2016 IPR005790 DNA polymerase III, delta subunit GO:0003677|GO:0006260 SPH21_RS12195 6c0a902c8d50ac5fe84e23ee0f61eb9a 335 Gene3D G3DSA:3.40.50.300 6 136 2.4E-17 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12195 6c0a902c8d50ac5fe84e23ee0f61eb9a 335 Gene3D G3DSA:1.10.8.60 143 228 1.7E-15 T 21-04-2016 SPH21_RS12195 6c0a902c8d50ac5fe84e23ee0f61eb9a 335 SUPERFAMILY SSF52540 10 205 2.44E-23 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12195 6c0a902c8d50ac5fe84e23ee0f61eb9a 335 SUPERFAMILY SSF48019 211 316 2.04E-7 T 21-04-2016 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: REACT_152|Reactome: REACT_1538|Reactome: REACT_216|Reactome: REACT_22172|Reactome: REACT_383 SPH21_RS12195 6c0a902c8d50ac5fe84e23ee0f61eb9a 335 Pfam PF06144 DNA polymerase III, delta subunit 19 188 3.6E-25 T 21-04-2016 IPR010372 DNA polymerase III delta, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0009360 SPH21_RS12195 6c0a902c8d50ac5fe84e23ee0f61eb9a 335 PANTHER PTHR34388 1 335 5.7E-53 T 21-04-2016 SPH21_RS26445 c5030a3457c0081f38ee0de53e2e13fa 375 PANTHER PTHR34220:SF1 28 375 7.1E-55 T 21-04-2016 SPH21_RS26445 c5030a3457c0081f38ee0de53e2e13fa 375 PANTHER PTHR34220 28 375 7.1E-55 T 21-04-2016 SPH21_RS26445 c5030a3457c0081f38ee0de53e2e13fa 375 SUPERFAMILY SSF55874 234 348 3.01E-5 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26445 c5030a3457c0081f38ee0de53e2e13fa 375 Pfam PF06580 Histidine kinase 180 257 2.0E-26 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PANTHER PTHR30620:SF5 496 775 0.0 T 21-04-2016 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PANTHER PTHR30620:SF5 88 480 0.0 T 21-04-2016 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PANTHER PTHR30620:SF5 2 70 0.0 T 21-04-2016 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 SUPERFAMILY SSF51445 42 403 3.47E-107 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 SMART SM01217 695 764 3.1E-33 T 21-04-2016 IPR026891 Fibronectin type III-like domain SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PRINTS PR00133 Glycosyl hydrolase family 3 signature 179 195 4.0E-21 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PRINTS PR00133 Glycosyl hydrolase family 3 signature 114 130 4.0E-21 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PRINTS PR00133 Glycosyl hydrolase family 3 signature 286 304 4.0E-21 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PRINTS PR00133 Glycosyl hydrolase family 3 signature 133 152 4.0E-21 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PRINTS PR00133 Glycosyl hydrolase family 3 signature 216 232 4.0E-21 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 55 363 4.4E-89 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 Gene3D G3DSA:3.40.50.1700 390 661 2.1E-76 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 405 658 3.9E-59 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 Gene3D G3DSA:3.20.20.300 41 380 1.7E-111 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 Pfam PF14310 Fibronectin type III-like domain 695 764 1.1E-22 T 21-04-2016 IPR026891 Fibronectin type III-like domain SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PANTHER PTHR30620 496 775 0.0 T 21-04-2016 IPR026892 Glycoside hydrolase family 3 GO:0004553 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PANTHER PTHR30620 88 480 0.0 T 21-04-2016 IPR026892 Glycoside hydrolase family 3 GO:0004553 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 PANTHER PTHR30620 2 70 0.0 T 21-04-2016 IPR026892 Glycoside hydrolase family 3 GO:0004553 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 SUPERFAMILY SSF52279 504 661 7.72E-57 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS07005 e9ab1e13714d82d9dc03d4d9f2209f1f 775 SUPERFAMILY SSF52279 404 473 7.72E-57 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS13210 7d245d2d71dccaf053fa5ee53b270df3 95 SUPERFAMILY SSF54909 3 90 1.32E-25 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS13210 7d245d2d71dccaf053fa5ee53b270df3 95 Pfam PF03992 Antibiotic biosynthesis monooxygenase 3 76 1.1E-13 T 21-04-2016 IPR007138 Antibiotic biosynthesis monooxygenase domain SPH21_RS13210 7d245d2d71dccaf053fa5ee53b270df3 95 Gene3D G3DSA:3.30.70.900 1 89 9.0E-28 T 21-04-2016 SPH21_RS13210 7d245d2d71dccaf053fa5ee53b270df3 95 PANTHER PTHR33336:SF5 1 89 3.7E-19 T 21-04-2016 SPH21_RS13210 7d245d2d71dccaf053fa5ee53b270df3 95 PANTHER PTHR33336 1 89 3.7E-19 T 21-04-2016 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 Gene3D G3DSA:3.20.20.80 31 324 1.2E-75 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 PANTHER PTHR10030:SF25 37 397 1.5E-48 T 21-04-2016 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 SMART SM00812 30 360 1.2E-59 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 PANTHER PTHR10030 37 397 1.5E-48 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 SUPERFAMILY SSF51445 33 324 1.33E-78 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 Pfam PF01120 Alpha-L-fucosidase 31 321 3.4E-66 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 PRINTS PR00741 Glycosyl hydrolase family 29 signature 307 329 3.0E-13 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 PRINTS PR00741 Glycosyl hydrolase family 29 signature 274 295 3.0E-13 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS10665 aabe307fc6d148d4cb2eaf3cb1b9cb50 456 PRINTS PR00741 Glycosyl hydrolase family 29 signature 104 120 3.0E-13 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS07890 2526080fe3e9e073e9e2a6af970e9fac 345 PANTHER PTHR11432:SF3 6 344 7.0E-149 T 21-04-2016 SPH21_RS07890 2526080fe3e9e073e9e2a6af970e9fac 345 Hamap MF_01350 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic [ndhA]. 5 341 24.441 T 21-04-2016 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 SPH21_RS07890 2526080fe3e9e073e9e2a6af970e9fac 345 PANTHER PTHR11432 6 344 7.0E-149 T 21-04-2016 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 SPH21_RS07890 2526080fe3e9e073e9e2a6af970e9fac 345 ProSitePatterns PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 217 230 - T 21-04-2016 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 SPH21_RS07890 2526080fe3e9e073e9e2a6af970e9fac 345 Pfam PF00146 NADH dehydrogenase 13 334 6.2E-125 T 21-04-2016 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PANTHER PTHR22912:SF159 8 293 1.5E-72 T 21-04-2016 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 7 286 1.6E-23 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 Gene3D G3DSA:3.50.50.60 6 130 1.7E-36 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 Gene3D G3DSA:3.50.50.60 250 297 1.7E-36 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 105 123 1.9E-13 T 21-04-2016 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 9 28 1.9E-13 T 21-04-2016 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 251 273 1.9E-13 T 21-04-2016 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PANTHER PTHR22912 8 293 1.5E-72 T 21-04-2016 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 143 167 5.7E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 106 114 5.7E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 8 30 5.7E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 128 140 5.7E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 261 279 5.7E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 Gene3D G3DSA:3.50.50.60 131 228 8.9E-34 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS13620 30a318d2a57ffdb67eda43e242269798 302 SUPERFAMILY SSF51905 1 297 1.53E-31 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS00525 0f02f3f7cf96b0c3f7f7cb7ed1967e4a 221 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 1 212 2.4E-15 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS00525 0f02f3f7cf96b0c3f7f7cb7ed1967e4a 221 Gene3D G3DSA:3.60.10.10 2 164 3.5E-18 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS00525 0f02f3f7cf96b0c3f7f7cb7ed1967e4a 221 PANTHER PTHR14859 1 221 1.1E-29 T 21-04-2016 IPR027317 PGAP2-interacting protein SPH21_RS00525 0f02f3f7cf96b0c3f7f7cb7ed1967e4a 221 Gene3D G3DSA:3.60.10.10 176 220 4.1E-4 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS00525 0f02f3f7cf96b0c3f7f7cb7ed1967e4a 221 SUPERFAMILY SSF56219 1 219 1.7E-31 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS15285 c70051ba742696ba6f4d4bf50fcf489a 138 SUPERFAMILY SSF54637 1 132 7.29E-40 T 21-04-2016 IPR029069 HotDog domain SPH21_RS15285 c70051ba742696ba6f4d4bf50fcf489a 138 Pfam PF03061 Thioesterase superfamily 18 101 1.2E-13 T 21-04-2016 IPR006683 Thioesterase domain SPH21_RS15285 c70051ba742696ba6f4d4bf50fcf489a 138 PANTHER PTHR31793 3 136 2.0E-43 T 21-04-2016 SPH21_RS15285 c70051ba742696ba6f4d4bf50fcf489a 138 Gene3D G3DSA:3.10.129.10 2 130 3.2E-44 T 21-04-2016 IPR029069 HotDog domain SPH21_RS15285 c70051ba742696ba6f4d4bf50fcf489a 138 PIRSF PIRSF003230 1 137 2.8E-38 T 21-04-2016 IPR006684 Acyl-CoA thioester hydrolase YbgC/YbaW family GO:0016787 SPH21_RS15285 c70051ba742696ba6f4d4bf50fcf489a 138 TIGRFAM TIGR00051 TIGR00051: acyl-CoA thioester hydrolase, YbgC/YbaW family 8 119 5.2E-27 T 21-04-2016 IPR006684 Acyl-CoA thioester hydrolase YbgC/YbaW family GO:0016787 SPH21_RS15285 c70051ba742696ba6f4d4bf50fcf489a 138 PANTHER PTHR31793:SF9 3 136 2.0E-43 T 21-04-2016 SPH21_RS07855 372ac32169f6504d6d8a38dd9921246a 125 PANTHER PTHR11058:SF5 1 125 1.4E-49 T 21-04-2016 SPH21_RS07855 372ac32169f6504d6d8a38dd9921246a 125 PANTHER PTHR11058 1 125 1.4E-49 T 21-04-2016 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 SPH21_RS07855 372ac32169f6504d6d8a38dd9921246a 125 Hamap MF_01394 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic [ndhC]. 8 125 18.338 T 21-04-2016 IPR023043 NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid GO:0016651|GO:0055114 SPH21_RS07855 372ac32169f6504d6d8a38dd9921246a 125 Pfam PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 29 124 2.3E-34 T 21-04-2016 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 SPH21_RS25890 e3de73135d2007f34c2f20604add4257 217 Gene3D G3DSA:1.25.40.10 150 204 1.2E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25890 e3de73135d2007f34c2f20604add4257 217 Pfam PF13432 Tetratricopeptide repeat 101 159 4.6E-7 T 21-04-2016 SPH21_RS25890 e3de73135d2007f34c2f20604add4257 217 Pfam PF13174 Tetratricopeptide repeat 173 201 2.5E-4 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS25890 e3de73135d2007f34c2f20604add4257 217 SUPERFAMILY SSF48452 84 207 6.95E-17 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25890 e3de73135d2007f34c2f20604add4257 217 Gene3D G3DSA:1.25.40.10 69 149 2.4E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25890 e3de73135d2007f34c2f20604add4257 217 SMART SM00028 131 164 5.5 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS25890 e3de73135d2007f34c2f20604add4257 217 SMART SM00028 168 201 4.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS13485 9fb27bc2df023b201e82198694cb36ef 334 PANTHER PTHR30294 13 278 4.9E-58 T 21-04-2016 SPH21_RS13485 9fb27bc2df023b201e82198694cb36ef 334 PANTHER PTHR30294 302 334 4.9E-58 T 21-04-2016 SPH21_RS13485 9fb27bc2df023b201e82198694cb36ef 334 PANTHER PTHR30294:SF20 13 278 4.9E-58 T 21-04-2016 SPH21_RS13485 9fb27bc2df023b201e82198694cb36ef 334 PANTHER PTHR30294:SF20 302 334 4.9E-58 T 21-04-2016 SPH21_RS13485 9fb27bc2df023b201e82198694cb36ef 334 Pfam PF12679 ABC-2 family transporter protein 25 330 1.2E-28 T 21-04-2016 IPR032688 ABC-2 family transporter protein GO:0006810 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 PANTHER PTHR10196 1 497 1.1E-189 T 21-04-2016 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 362 382 - T 21-04-2016 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 258 449 1.1E-35 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 PIRSF PIRSF000538 1 497 1.1E-126 T 21-04-2016 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|UniPathway: UPA00618 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 SUPERFAMILY SSF53067 1 249 2.39E-61 T 21-04-2016 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 Gene3D G3DSA:3.30.420.40 1 250 4.0E-60 T 21-04-2016 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 Gene3D G3DSA:3.30.420.40 252 494 8.6E-52 T 21-04-2016 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 3 249 7.6E-58 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 SUPERFAMILY SSF53067 253 494 5.49E-55 T 21-04-2016 SPH21_RS22495 c78096a319fe92dd16a4c0f6dbd68a94 497 PANTHER PTHR10196:SF41 1 497 1.1E-189 T 21-04-2016 SPH21_RS07130 9360d241cc766c51256720b6f0a0233d 454 PIRSF PIRSF006603 5 452 6.7E-71 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS07130 9360d241cc766c51256720b6f0a0233d 454 TIGRFAM TIGR00797 matE: MATE efflux family protein 20 421 1.3E-87 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS07130 9360d241cc766c51256720b6f0a0233d 454 Pfam PF01554 MatE 20 179 1.5E-29 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS07130 9360d241cc766c51256720b6f0a0233d 454 Pfam PF01554 MatE 247 407 1.5E-26 T 21-04-2016 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: REACT_15518|Reactome: REACT_20633 SPH21_RS07130 9360d241cc766c51256720b6f0a0233d 454 PANTHER PTHR11206:SF153 7 441 1.4E-117 T 21-04-2016 SPH21_RS07130 9360d241cc766c51256720b6f0a0233d 454 PANTHER PTHR11206 7 441 1.4E-117 T 21-04-2016 SPH21_RS16515 272390d38aab431d9329495994d97474 426 TIGRFAM TIGR00508 bioA: adenosylmethionine-8-amino-7-oxononanoate transaminase 15 421 7.0E-164 T 21-04-2016 IPR005815 Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA GO:0004015|GO:0009102 KEGG: 00780+2.6.1.62|UniPathway: UPA00078 SPH21_RS16515 272390d38aab431d9329495994d97474 426 Gene3D G3DSA:3.40.640.10 64 323 2.2E-81 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS16515 272390d38aab431d9329495994d97474 426 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 235 272 - T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS16515 272390d38aab431d9329495994d97474 426 PANTHER PTHR11986 6 425 7.1E-174 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS16515 272390d38aab431d9329495994d97474 426 SUPERFAMILY SSF53383 7 425 1.02E-114 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS16515 272390d38aab431d9329495994d97474 426 Gene3D G3DSA:3.90.1150.10 326 425 1.8E-45 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS16515 272390d38aab431d9329495994d97474 426 Gene3D G3DSA:3.90.1150.10 6 63 1.8E-45 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS16515 272390d38aab431d9329495994d97474 426 Pfam PF00202 Aminotransferase class-III 28 421 2.2E-107 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS16515 272390d38aab431d9329495994d97474 426 PANTHER PTHR11986:SF8 6 425 7.1E-174 T 21-04-2016 SPH21_RS24065 9fd227c3cb20ee3697b04c527c00dd6d 254 Pfam PF13460 NAD(P)H-binding 35 173 1.1E-9 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24065 9fd227c3cb20ee3697b04c527c00dd6d 254 PANTHER PTHR14194:SF69 1 244 1.0E-97 T 21-04-2016 SPH21_RS24065 9fd227c3cb20ee3697b04c527c00dd6d 254 PANTHER PTHR14194 1 244 1.0E-97 T 21-04-2016 SPH21_RS24065 9fd227c3cb20ee3697b04c527c00dd6d 254 SUPERFAMILY SSF51735 1 215 4.23E-32 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24065 9fd227c3cb20ee3697b04c527c00dd6d 254 Gene3D G3DSA:3.40.50.720 1 205 1.5E-26 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18860 fa9bf8c3389fc80bc279131f51dfdcc5 311 PANTHER PTHR32322 11 310 1.1E-54 T 21-04-2016 SPH21_RS18860 fa9bf8c3389fc80bc279131f51dfdcc5 311 Pfam PF00892 EamA-like transporter family 7 142 6.9E-15 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS18860 fa9bf8c3389fc80bc279131f51dfdcc5 311 Pfam PF00892 EamA-like transporter family 156 292 9.0E-24 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS18860 fa9bf8c3389fc80bc279131f51dfdcc5 311 PANTHER PTHR32322:SF8 11 310 1.1E-54 T 21-04-2016 SPH21_RS18860 fa9bf8c3389fc80bc279131f51dfdcc5 311 SUPERFAMILY SSF103481 191 296 8.11E-18 T 21-04-2016 SPH21_RS18860 fa9bf8c3389fc80bc279131f51dfdcc5 311 SUPERFAMILY SSF103481 41 143 4.32E-7 T 21-04-2016 SPH21_RS26035 1b5557cd1f9db73c9c6e3f80c036cc72 320 Pfam PF14903 WG containing repeat 111 141 1.2E-5 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS21490 b68ddc9dabc4e682875452145334b755 421 PANTHER PTHR23513 13 421 4.2E-85 T 21-04-2016 SPH21_RS21490 b68ddc9dabc4e682875452145334b755 421 Gene3D G3DSA:1.20.1250.20 238 413 6.1E-9 T 21-04-2016 SPH21_RS21490 b68ddc9dabc4e682875452145334b755 421 Gene3D G3DSA:1.20.1250.20 17 203 9.8E-14 T 21-04-2016 SPH21_RS21490 b68ddc9dabc4e682875452145334b755 421 Pfam PF05977 Transmembrane secretion effector 6 411 4.6E-26 T 21-04-2016 IPR010290 Transmembrane secretion effector SPH21_RS21490 b68ddc9dabc4e682875452145334b755 421 PANTHER PTHR23513:SF9 13 421 4.2E-85 T 21-04-2016 SPH21_RS21490 b68ddc9dabc4e682875452145334b755 421 SUPERFAMILY SSF103473 18 412 1.44E-32 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13065 3253df63cb2cf1d8b1a7a1f78c54ebcd 336 PANTHER PTHR37826 6 297 7.5E-62 T 21-04-2016 SPH21_RS13065 3253df63cb2cf1d8b1a7a1f78c54ebcd 336 Pfam PF13421 SPFH domain-Band 7 family 26 234 2.2E-75 T 21-04-2016 SPH21_RS13065 3253df63cb2cf1d8b1a7a1f78c54ebcd 336 SUPERFAMILY SSF117892 122 229 1.19E-7 T 21-04-2016 IPR001107 Band 7 domain SPH21_RS13065 3253df63cb2cf1d8b1a7a1f78c54ebcd 336 PANTHER PTHR37826:SF2 6 297 7.5E-62 T 21-04-2016 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 Gene3D G3DSA:3.40.50.270 1 143 4.5E-46 T 21-04-2016 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 SMART SM00226 1 142 3.0E-48 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 3 140 1.3E-35 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 44 60 3.4E-20 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 3 20 3.4E-20 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 78 93 3.4E-20 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 115 130 3.4E-20 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 102 115 3.4E-20 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 PANTHER PTHR11717:SF7 1 143 7.3E-48 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 SUPERFAMILY SSF52788 1 143 1.22E-43 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS05750 0ca9ab337ad000b03fa81350ea056876 145 PANTHER PTHR11717 1 143 7.3E-48 T 21-04-2016 SPH21_RS15220 85f8d81275466f9f6ede081d84c2638b 421 SUPERFAMILY SSF103473 6 411 2.09E-32 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS15220 85f8d81275466f9f6ede081d84c2638b 421 PANTHER PTHR23522:SF4 1 421 1.4E-186 T 21-04-2016 SPH21_RS15220 85f8d81275466f9f6ede081d84c2638b 421 TIGRFAM TIGR00889 2A0110: nucleoside transporter 1 414 9.1E-145 T 21-04-2016 IPR004740 Nucleoside:H+ symporter GO:0005337|GO:0015858|GO:0016021 SPH21_RS15220 85f8d81275466f9f6ede081d84c2638b 421 Gene3D G3DSA:1.20.1250.20 7 188 3.4E-8 T 21-04-2016 SPH21_RS15220 85f8d81275466f9f6ede081d84c2638b 421 PANTHER PTHR23522 1 421 1.4E-186 T 21-04-2016 SPH21_RS15220 85f8d81275466f9f6ede081d84c2638b 421 Pfam PF03825 Nucleoside H+ symporter 1 409 3.0E-127 T 21-04-2016 SPH21_RS15220 85f8d81275466f9f6ede081d84c2638b 421 Gene3D G3DSA:1.20.1250.20 207 411 1.3E-22 T 21-04-2016 SPH21_RS12930 376c6942433cab606b8eeb05bcad8cb7 73 Pfam PF09234 Domain of unknown function (DUF1963) 6 70 4.0E-13 T 21-04-2016 IPR015315 Protein of unknown function DUF1963 SPH21_RS12930 376c6942433cab606b8eeb05bcad8cb7 73 SUPERFAMILY SSF103032 18 72 1.7E-9 T 21-04-2016 IPR015315 Protein of unknown function DUF1963 SPH21_RS12930 376c6942433cab606b8eeb05bcad8cb7 73 Gene3D G3DSA:2.30.320.10 24 73 1.5E-12 T 21-04-2016 IPR015315 Protein of unknown function DUF1963 SPH21_RS12845 6c9b22c9a086142cd5610b0765c2a8c5 408 PANTHER PTHR30489:SF2 217 408 2.9E-38 T 21-04-2016 SPH21_RS12845 6c9b22c9a086142cd5610b0765c2a8c5 408 PANTHER PTHR30489:SF2 6 196 2.9E-38 T 21-04-2016 SPH21_RS12845 6c9b22c9a086142cd5610b0765c2a8c5 408 Pfam PF02687 FtsX-like permease family 286 398 3.4E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS12845 6c9b22c9a086142cd5610b0765c2a8c5 408 PANTHER PTHR30489 217 408 2.9E-38 T 21-04-2016 SPH21_RS12845 6c9b22c9a086142cd5610b0765c2a8c5 408 PANTHER PTHR30489 6 196 2.9E-38 T 21-04-2016 SPH21_RS12845 6c9b22c9a086142cd5610b0765c2a8c5 408 Pfam PF12704 MacB-like periplasmic core domain 18 199 6.9E-12 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS17015 cd39500f3bde3188aedfa66b9b5136cc 436 Gene3D G3DSA:1.20.1600.10 20 430 7.4E-70 T 21-04-2016 SPH21_RS17015 cd39500f3bde3188aedfa66b9b5136cc 436 SUPERFAMILY SSF56954 4 429 2.88E-73 T 21-04-2016 SPH21_RS17015 cd39500f3bde3188aedfa66b9b5136cc 436 PANTHER PTHR30026:SF4 24 436 2.5E-47 T 21-04-2016 SPH21_RS17015 cd39500f3bde3188aedfa66b9b5136cc 436 PANTHER PTHR30026 24 436 2.5E-47 T 21-04-2016 SPH21_RS17015 cd39500f3bde3188aedfa66b9b5136cc 436 Pfam PF02321 Outer membrane efflux protein 239 422 1.4E-28 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS17015 cd39500f3bde3188aedfa66b9b5136cc 436 Pfam PF02321 Outer membrane efflux protein 27 214 1.2E-24 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS08430 3749dee44bfbc2bbc5e032578cc84612 76 SUPERFAMILY SSF55856 2 73 2.36E-15 T 21-04-2016 IPR001199 Cytochrome b5-like heme/steroid binding domain SPH21_RS08430 3749dee44bfbc2bbc5e032578cc84612 76 SMART SM01117 4 75 1.6E-14 T 21-04-2016 IPR001199 Cytochrome b5-like heme/steroid binding domain SPH21_RS08430 3749dee44bfbc2bbc5e032578cc84612 76 Gene3D G3DSA:3.10.120.10 2 61 1.2E-15 T 21-04-2016 IPR001199 Cytochrome b5-like heme/steroid binding domain SPH21_RS08430 3749dee44bfbc2bbc5e032578cc84612 76 Pfam PF00173 Cytochrome b5-like Heme/Steroid binding domain 6 68 2.3E-10 T 21-04-2016 IPR001199 Cytochrome b5-like heme/steroid binding domain SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 Gene3D G3DSA:2.40.10.10 175 312 2.5E-42 T 21-04-2016 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 TIGRFAM TIGR02037 degP_htrA_DO: peptidase Do 58 510 4.0E-131 T 21-04-2016 IPR011782 Peptidase S1C, Do GO:0004252|GO:0006508 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 SUPERFAMILY SSF50156 292 402 1.71E-22 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 SMART SM00228 311 393 1.2E-12 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 SMART SM00228 427 506 3.4 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 Gene3D G3DSA:2.30.42.10 313 403 1.3E-27 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 Pfam PF13365 Trypsin-like peptidase domain 113 272 4.6E-34 T 21-04-2016 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PANTHER PTHR22939 58 228 6.2E-117 T 21-04-2016 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PANTHER PTHR22939 244 422 6.2E-117 T 21-04-2016 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 Gene3D G3DSA:2.30.42.10 428 501 1.7E-10 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PANTHER PTHR22939:SF79 58 228 6.2E-117 T 21-04-2016 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PANTHER PTHR22939:SF79 244 422 6.2E-117 T 21-04-2016 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 SUPERFAMILY SSF50494 110 210 1.62E-62 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 SUPERFAMILY SSF50494 53 81 1.62E-62 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 SUPERFAMILY SSF50494 246 320 1.62E-62 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 Gene3D G3DSA:2.40.10.10 58 174 9.0E-40 T 21-04-2016 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 Pfam PF13180 PDZ domain 311 402 3.4E-20 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 SUPERFAMILY SSF50156 447 511 1.2E-8 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PRINTS PR00834 HtrA/DegQ protease family signature 351 363 2.4E-36 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PRINTS PR00834 HtrA/DegQ protease family signature 122 134 2.4E-36 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PRINTS PR00834 HtrA/DegQ protease family signature 143 163 2.4E-36 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PRINTS PR00834 HtrA/DegQ protease family signature 265 282 2.4E-36 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS06920 07376899f307ee384b682db5d9cd673f 517 PRINTS PR00834 HtrA/DegQ protease family signature 243 260 2.4E-36 T 21-04-2016 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SPH21_RS10355 39d6e39140c54fbf0453f09824c4aaae 193 Pfam PF13628 Domain of unknown function (DUF4142) 54 189 4.0E-46 T 21-04-2016 IPR025419 Domain of unknown function DUF4142 SPH21_RS10355 39d6e39140c54fbf0453f09824c4aaae 193 PANTHER PTHR38593:SF1 1 192 1.0E-18 T 21-04-2016 SPH21_RS10355 39d6e39140c54fbf0453f09824c4aaae 193 Gene3D G3DSA:1.20.1260.10 49 191 4.8E-12 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS10355 39d6e39140c54fbf0453f09824c4aaae 193 PANTHER PTHR38593 1 192 1.0E-18 T 21-04-2016 SPH21_RS03835 e81ec63dd38d9000721ffb545238ef31 133 PANTHER PTHR21366 5 133 1.2E-27 T 21-04-2016 SPH21_RS03835 e81ec63dd38d9000721ffb545238ef31 133 SUPERFAMILY SSF54593 1 130 3.89E-31 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS03835 e81ec63dd38d9000721ffb545238ef31 133 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 9 128 2.6E-20 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS03835 e81ec63dd38d9000721ffb545238ef31 133 Gene3D G3DSA:3.10.180.10 4 130 1.4E-32 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 PIRSF PIRSF000446 1 294 7.8E-97 T 21-04-2016 IPR024925 Malonyl CoA-acyl carrier protein transacylase KEGG: 00061+2.3.1.39|MetaCyc: PWY-4381|MetaCyc: PWY-6799|MetaCyc: PWY-7388|UniPathway: UPA00094 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 Gene3D G3DSA:3.40.366.10 3 119 1.2E-69 T 21-04-2016 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 Gene3D G3DSA:3.40.366.10 192 291 1.2E-69 T 21-04-2016 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 PANTHER PTHR10982 4 293 3.3E-133 T 21-04-2016 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 SUPERFAMILY SSF55048 127 187 3.27E-16 T 21-04-2016 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 Gene3D G3DSA:3.30.70.250 123 191 5.1E-27 T 21-04-2016 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 SUPERFAMILY SSF52151 3 119 5.23E-73 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 SUPERFAMILY SSF52151 185 291 5.23E-73 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 TIGRFAM TIGR00128 fabD: malonyl CoA-acyl carrier protein transacylase 1 286 4.1E-100 T 21-04-2016 IPR004410 Malonyl CoA-acyl carrier protein transacylase, FabD-type GO:0004314 KEGG: 00061+2.3.1.39|MetaCyc: PWY-4381|MetaCyc: PWY-6799|MetaCyc: PWY-7388 SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 6 295 8.8E-30 T 21-04-2016 IPR020801 Polyketide synthase, acyl transferase domain SPH21_RS06485 7d568622efbe47b9013250d7039e4af0 295 Pfam PF00698 Acyl transferase domain 5 289 5.8E-39 T 21-04-2016 IPR014043 Acyl transferase SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 Pfam PF00889 Elongation factor TS 75 278 1.3E-70 T 21-04-2016 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 ProSitePatterns PS01127 Elongation factor Ts signature 2. 79 89 - T 21-04-2016 IPR018101 Translation elongation factor Ts, conserved site GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 ProSitePatterns PS01126 Elongation factor Ts signature 1. 14 29 - T 21-04-2016 IPR018101 Translation elongation factor Ts, conserved site GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 SUPERFAMILY SSF54713 180 278 9.0E-44 T 21-04-2016 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 SUPERFAMILY SSF54713 60 96 9.0E-44 T 21-04-2016 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 SUPERFAMILY SSF46934 5 57 8.17E-18 T 21-04-2016 IPR009060 UBA-like GO:0005515 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 Hamap MF_00050 Elongation factor Ts [tsf]. 1 279 64.27 T 21-04-2016 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 Gene3D G3DSA:1.10.286.20 197 240 7.0E-18 T 21-04-2016 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 Gene3D G3DSA:1.10.8.10 5 57 5.9E-26 T 21-04-2016 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 Gene3D G3DSA:3.30.479.20 60 147 2.1E-17 T 21-04-2016 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 Gene3D G3DSA:3.30.479.20 241 278 1.7E-21 T 21-04-2016 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 Gene3D G3DSA:3.30.479.20 153 192 1.7E-21 T 21-04-2016 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 PANTHER PTHR11741 1 278 1.3E-95 T 21-04-2016 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 SPH21_RS07110 78ad3b40abcbeda589d63a98ae7ccb5e 279 TIGRFAM TIGR00116 tsf: translation elongation factor Ts 5 278 2.9E-81 T 21-04-2016 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 PRINTS PR00111 Alpha/beta hydrolase fold signature 114 127 4.0E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 4.0E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 PRINTS PR00111 Alpha/beta hydrolase fold signature 55 70 4.0E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 PANTHER PTHR10992 31 141 8.6E-37 T 21-04-2016 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 PANTHER PTHR10992 173 257 8.6E-37 T 21-04-2016 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 PANTHER PTHR10992:SF810 31 141 8.6E-37 T 21-04-2016 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 PANTHER PTHR10992:SF810 173 257 8.6E-37 T 21-04-2016 SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 Gene3D G3DSA:3.40.50.1820 28 262 8.6E-49 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 SUPERFAMILY SSF53474 17 261 3.78E-28 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04420 be0d8d524b5fad8842b535b617961dd8 263 Pfam PF12697 Alpha/beta hydrolase family 31 256 3.1E-14 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS26155 2224251a4e5e2af7d1b09de2d5d9a833 366 Pfam PF00535 Glycosyl transferase family 2 17 144 4.1E-32 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS26155 2224251a4e5e2af7d1b09de2d5d9a833 366 Gene3D G3DSA:3.90.550.10 14 237 8.1E-57 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS26155 2224251a4e5e2af7d1b09de2d5d9a833 366 PANTHER PTHR22916:SF28 14 261 2.3E-54 T 21-04-2016 SPH21_RS26155 2224251a4e5e2af7d1b09de2d5d9a833 366 PANTHER PTHR22916 14 261 2.3E-54 T 21-04-2016 SPH21_RS26155 2224251a4e5e2af7d1b09de2d5d9a833 366 SUPERFAMILY SSF53448 14 234 2.6E-58 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS04775 43b711ef84eb034f4dfdb39e7960aa89 123 SUPERFAMILY SSF46785 19 116 5.37E-32 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04775 43b711ef84eb034f4dfdb39e7960aa89 123 PANTHER PTHR33204 8 114 2.9E-37 T 21-04-2016 SPH21_RS04775 43b711ef84eb034f4dfdb39e7960aa89 123 Pfam PF01638 HxlR-like helix-turn-helix 30 115 6.3E-31 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS04775 43b711ef84eb034f4dfdb39e7960aa89 123 Gene3D G3DSA:1.10.10.10 12 120 1.0E-39 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04775 43b711ef84eb034f4dfdb39e7960aa89 123 PANTHER PTHR33204:SF8 8 114 2.9E-37 T 21-04-2016 SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 Pfam PF00155 Aminotransferase class I and II 170 482 1.8E-24 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 Pfam PF00392 Bacterial regulatory proteins, gntR family 18 81 4.7E-11 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 PANTHER PTHR11751 109 491 1.1E-66 T 21-04-2016 SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 Gene3D G3DSA:3.40.640.10 170 377 2.0E-54 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 PANTHER PTHR11751:SF10 109 491 1.1E-66 T 21-04-2016 SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 SUPERFAMILY SSF46785 10 84 2.76E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 SUPERFAMILY SSF53383 77 490 7.79E-77 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 SMART SM00345 22 81 3.4E-10 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 Gene3D G3DSA:1.10.10.10 10 82 8.0E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02655 bab002a122d03e4b94dd6e3af263ebae 498 Gene3D G3DSA:3.90.1150.10 378 454 7.0E-7 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS14255 031efe2a8ee65e04c1b6342f13f88b17 394 Gene3D G3DSA:1.50.10.110 41 342 1.9E-62 T 21-04-2016 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SPH21_RS14255 031efe2a8ee65e04c1b6342f13f88b17 394 PANTHER PTHR41379:SF1 40 352 2.3E-64 T 21-04-2016 SPH21_RS14255 031efe2a8ee65e04c1b6342f13f88b17 394 Pfam PF05426 Alginate lyase 58 333 1.6E-86 T 21-04-2016 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SPH21_RS14255 031efe2a8ee65e04c1b6342f13f88b17 394 SUPERFAMILY SSF48230 63 387 5.49E-58 T 21-04-2016 IPR008929 Chondroitin AC/alginate lyase SPH21_RS14255 031efe2a8ee65e04c1b6342f13f88b17 394 PANTHER PTHR41379 40 352 2.3E-64 T 21-04-2016 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 PIRSF PIRSF000188 8 360 6.1E-135 T 21-04-2016 IPR016211 Glutamate/phenylalanine/leucine/valine dehydrogenase, bacterial/archaeal GO:0016639|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 Gene3D G3DSA:3.40.50.720 156 343 1.5E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 SUPERFAMILY SSF51735 148 352 2.68E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 148 207 3.4E-7 T 21-04-2016 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 222 352 1.2E-11 T 21-04-2016 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 PANTHER PTHR11606 30 359 4.0E-112 T 21-04-2016 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 PANTHER PTHR11606:SF3 30 359 4.0E-112 T 21-04-2016 IPR016211 Glutamate/phenylalanine/leucine/valine dehydrogenase, bacterial/archaeal GO:0016639|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 SUPERFAMILY SSF53223 11 151 2.4E-40 T 21-04-2016 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 32 138 2.3E-22 T 21-04-2016 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 Gene3D G3DSA:3.40.192.10 10 155 6.6E-60 T 21-04-2016 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 294 305 4.0E-17 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 183 203 4.0E-17 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 73 87 4.0E-17 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 139 161 4.0E-17 T 21-04-2016 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 SPH21_RS19890 6fe4bcc461f4de3ea022eed386b373b7 360 SMART SM00839 151 359 8.1E-52 T 21-04-2016 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 SPH21_RS05045 bd701918d283a6c70a43b0d61b394451 74 SUPERFAMILY SSF48452 3 71 3.22E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05045 bd701918d283a6c70a43b0d61b394451 74 Pfam PF07980 SusD family 2 71 5.4E-10 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04545 f6e7f7f20c562579e249ab3a7d2f9f3e 131 PANTHER PTHR30086:SF7 2 131 4.6E-40 T 21-04-2016 SPH21_RS04545 f6e7f7f20c562579e249ab3a7d2f9f3e 131 PANTHER PTHR30086 2 131 4.6E-40 T 21-04-2016 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SPH21_RS04545 f6e7f7f20c562579e249ab3a7d2f9f3e 131 Pfam PF01810 LysE type translocator 15 131 3.7E-22 T 21-04-2016 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SPH21_RS09960 393443e82f2942790e78e3be53bfb77b 272 PANTHER PTHR22916 1 184 5.2E-23 T 21-04-2016 SPH21_RS09960 393443e82f2942790e78e3be53bfb77b 272 SUPERFAMILY SSF53448 1 207 4.13E-33 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09960 393443e82f2942790e78e3be53bfb77b 272 Pfam PF00535 Glycosyl transferase family 2 2 136 1.7E-12 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS09960 393443e82f2942790e78e3be53bfb77b 272 Gene3D G3DSA:3.90.550.10 1 191 4.9E-29 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS22060 5ad9272b60b9436ad375963bf00f9606 385 Pfam PF13905 Thioredoxin-like 280 371 6.5E-9 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS22060 5ad9272b60b9436ad375963bf00f9606 385 Gene3D G3DSA:3.40.30.10 262 382 4.1E-12 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS22060 5ad9272b60b9436ad375963bf00f9606 385 SUPERFAMILY SSF52833 261 373 2.71E-5 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS10000 bdbaaccfe7a4d8acc440529ec3816756 220 Gene3D G3DSA:3.30.1950.10 12 104 6.3E-16 T 21-04-2016 SPH21_RS10000 bdbaaccfe7a4d8acc440529ec3816756 220 Pfam PF10531 SLBB domain 109 155 1.1E-7 T 21-04-2016 IPR019554 Soluble ligand binding domain SPH21_RS10000 bdbaaccfe7a4d8acc440529ec3816756 220 Gene3D G3DSA:3.10.560.10 105 188 3.2E-17 T 21-04-2016 SPH21_RS10000 bdbaaccfe7a4d8acc440529ec3816756 220 Pfam PF02563 Polysaccharide biosynthesis/export protein 5 103 1.9E-15 T 21-04-2016 IPR003715 Polysaccharide export protein GO:0015159|GO:0015774|GO:0016020 SPH21_RS10000 bdbaaccfe7a4d8acc440529ec3816756 220 PANTHER PTHR33619 9 28 2.4E-33 T 21-04-2016 SPH21_RS10000 bdbaaccfe7a4d8acc440529ec3816756 220 PANTHER PTHR33619 55 220 2.4E-33 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 Pfam PF07971 Glycosyl hydrolase family 92 217 731 2.5E-142 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 Gene3D G3DSA:2.70.98.10 25 292 3.7E-51 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 Gene3D G3DSA:3.30.2080.10 598 742 3.1E-62 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 Gene3D G3DSA:1.20.1050.60 325 412 1.1E-23 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 Gene3D G3DSA:1.20.1610.10 428 597 4.8E-45 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 PANTHER PTHR12143:SF22 365 736 3.8E-121 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 PANTHER PTHR12143:SF22 5 347 3.8E-121 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 PANTHER PTHR12143 365 736 3.8E-121 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 PANTHER PTHR12143 5 347 3.8E-121 T 21-04-2016 SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 8 736 6.2E-215 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS22555 3df5ce8eb711cbfba527873ba564c52c 759 SUPERFAMILY SSF48208 239 729 1.79E-24 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS12290 62926a38a82ac56d990067100d384f76 448 SUPERFAMILY SSF51126 14 27 2.48E-73 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS12290 62926a38a82ac56d990067100d384f76 448 SUPERFAMILY SSF51126 57 430 2.48E-73 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS12290 62926a38a82ac56d990067100d384f76 448 Gene3D G3DSA:2.160.20.10 57 425 5.9E-84 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS12290 62926a38a82ac56d990067100d384f76 448 Pfam PF12708 Pectate lyase superfamily protein 61 133 2.9E-6 T 21-04-2016 IPR024535 Pectate lyase superfamily protein SPH21_RS12290 62926a38a82ac56d990067100d384f76 448 PANTHER PTHR31339:SF0 59 429 2.3E-83 T 21-04-2016 SPH21_RS12290 62926a38a82ac56d990067100d384f76 448 PANTHER PTHR31339 59 429 2.3E-83 T 21-04-2016 SPH21_RS12290 62926a38a82ac56d990067100d384f76 448 Pfam PF00295 Glycosyl hydrolases family 28 140 355 6.7E-23 T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 TIGRFAM TIGR01533 lipo_e_P4: 5'-nucleotidase, lipoprotein e(P4) family 24 254 2.0E-85 T 21-04-2016 IPR006423 5-nucleotidase lipoprotein e(P4) GO:0009279 SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 PIRSF PIRSF019271 10 255 5.0E-85 T 21-04-2016 IPR006423 5-nucleotidase lipoprotein e(P4) GO:0009279 SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 PANTHER PTHR31284:SF10 213 229 9.5E-59 T 21-04-2016 SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 PANTHER PTHR31284:SF10 29 195 9.5E-59 T 21-04-2016 SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 Pfam PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) 26 229 8.4E-48 T 21-04-2016 IPR005519 Acid phosphatase, class B-like SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 SUPERFAMILY SSF56784 43 234 1.1E-36 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 Gene3D G3DSA:3.40.50.1000 32 235 1.1E-55 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 PANTHER PTHR31284 213 229 9.5E-59 T 21-04-2016 SPH21_RS25740 e867c4e6c69ca5f3ff2a2fa615917328 255 PANTHER PTHR31284 29 195 9.5E-59 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 TIGRFAM TIGR04018 Bthiol_YpdA: putative bacillithiol system oxidoreductase, YpdA family 5 318 1.3E-149 T 21-04-2016 IPR023856 Bacillithiol biosynthesis thiol disulphide oxidoreductase, YpdA SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 Gene3D G3DSA:3.50.50.60 124 314 1.2E-26 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 SUPERFAMILY SSF51905 1 317 3.89E-39 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PANTHER PTHR23023 1 317 4.6E-63 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 Gene3D G3DSA:3.50.50.60 2 123 6.1E-18 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PANTHER PTHR23023:SF55 1 317 4.6E-63 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 158 176 3.5E-11 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 271 293 3.5E-11 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 3.5E-11 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 241 257 3.5E-11 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 118 136 3.5E-11 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 7 290 1.0E-100 T 21-04-2016 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 281 299 6.1E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 154 178 6.1E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 5 27 6.1E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS15840 76267def01cfe64df6b33d8e27e99267 319 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 119 127 6.1E-15 T 21-04-2016 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SPH21_RS23785 3673cfae293a279798c14967ea8602c2 129 SUPERFAMILY SSF56281 10 95 9.52E-9 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS23785 3673cfae293a279798c14967ea8602c2 129 Gene3D G3DSA:3.60.15.10 4 109 9.5E-10 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS23785 3673cfae293a279798c14967ea8602c2 129 Pfam PF12706 Beta-lactamase superfamily domain 23 94 1.1E-6 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 SUPERFAMILY SSF110921 390 503 1.96E-15 T 21-04-2016 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 Pfam PF08502 LeuA allosteric (dimerisation) domain 369 502 4.1E-21 T 21-04-2016 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 PANTHER PTHR10277:SF9 1 504 2.1E-135 T 21-04-2016 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 12 28 - T 21-04-2016 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 Pfam PF00682 HMGL-like 4 273 1.7E-50 T 21-04-2016 IPR000891 Pyruvate carboxyltransferase GO:0003824 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 SMART SM00917 368 504 1.1E-10 T 21-04-2016 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871|UniPathway: UPA00048 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 PANTHER PTHR10277 1 504 2.1E-135 T 21-04-2016 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 SUPERFAMILY SSF51569 1 291 8.97E-66 T 21-04-2016 SPH21_RS11230 ccb6f778d5a2f2fad89761b7a6edc7fa 504 Gene3D G3DSA:3.20.20.70 1 345 1.7E-90 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS18735 5c0b3a2a8d598435f495d78017589c05 408 Pfam PF07690 Major Facilitator Superfamily 22 243 1.0E-14 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS18735 5c0b3a2a8d598435f495d78017589c05 408 PANTHER PTHR23517:SF4 17 389 7.9E-90 T 21-04-2016 SPH21_RS18735 5c0b3a2a8d598435f495d78017589c05 408 Gene3D G3DSA:1.20.1250.20 20 202 1.4E-17 T 21-04-2016 SPH21_RS18735 5c0b3a2a8d598435f495d78017589c05 408 Gene3D G3DSA:1.20.1250.20 224 396 2.9E-17 T 21-04-2016 SPH21_RS18735 5c0b3a2a8d598435f495d78017589c05 408 PANTHER PTHR23517 17 389 7.9E-90 T 21-04-2016 SPH21_RS18735 5c0b3a2a8d598435f495d78017589c05 408 SUPERFAMILY SSF103473 15 394 1.18E-43 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 Gene3D G3DSA:2.40.170.20 251 806 5.9E-113 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 PANTHER PTHR32552 110 806 6.0E-98 T 21-04-2016 SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 Pfam PF13620 Carboxypeptidase regulatory-like domain 25 92 4.9E-12 T 21-04-2016 SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 SUPERFAMILY SSF49464 25 118 1.33E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 Gene3D G3DSA:2.170.130.10 107 246 5.7E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 SUPERFAMILY SSF56935 103 806 2.45E-98 T 21-04-2016 SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 TIGRFAM TIGR01783 TonB-siderophor: TonB-dependent siderophore receptor 140 764 8.2E-78 T 21-04-2016 IPR010105 TonB-dependent siderophore receptor GO:0004872|GO:0005506|GO:0015891 SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 PANTHER PTHR32552:SF10 110 806 6.0E-98 T 21-04-2016 SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 Gene3D G3DSA:2.60.40.1120 26 106 4.4E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04540 7c42c0d75db835107542a1c762b3aee8 806 Pfam PF07715 TonB-dependent Receptor Plug Domain 140 236 6.2E-8 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS22230 f7bb202121bded25e64e4873dff18edb 376 PANTHER PTHR31061 2 376 1.6E-50 T 21-04-2016 SPH21_RS22230 f7bb202121bded25e64e4873dff18edb 376 Pfam PF07786 Protein of unknown function (DUF1624) 7 161 2.0E-7 T 21-04-2016 IPR012429 Protein of unknown function DUF1624 KEGG: 00531+2.3.1.78 SPH21_RS22230 f7bb202121bded25e64e4873dff18edb 376 PANTHER PTHR31061:SF1 2 376 1.6E-50 T 21-04-2016 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 Pfam PF04542 Sigma-70 region 2 75 140 5.0E-14 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 PANTHER PTHR30173:SF21 46 225 5.5E-38 T 21-04-2016 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 SUPERFAMILY SSF88946 58 142 1.96E-16 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 PANTHER PTHR30173 46 225 5.5E-38 T 21-04-2016 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 Gene3D G3DSA:1.10.10.10 163 225 1.1E-19 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 73 223 8.3E-23 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 Pfam PF08281 Sigma-70, region 4 168 220 2.2E-16 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 SUPERFAMILY SSF88659 165 226 3.27E-15 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS22960 120d8f48603f74385eaeb6726c1197fc 242 Gene3D G3DSA:1.10.1740.10 55 142 6.9E-18 T 21-04-2016 SPH21_RS01580 77736289492e4111e80cb63dcbeddf3b 128 PANTHER PTHR10584 5 66 5.1E-18 T 21-04-2016 SPH21_RS01580 77736289492e4111e80cb63dcbeddf3b 128 PANTHER PTHR10584:SF191 5 66 5.1E-18 T 21-04-2016 SPH21_RS01580 77736289492e4111e80cb63dcbeddf3b 128 Pfam PF04241 Protein of unknown function (DUF423) 19 110 1.7E-27 T 21-04-2016 IPR006696 Protein of unknown function DUF423 SPH21_RS23275 793bbabaa57a2c56eb1acb09d5e81285 455 ProDom PD092006 MEMBRANE YWOB TRANSMEMBRANE 120 238 4.0E-12 T 21-04-2016 IPR020218 Uncharacterised protein family, YwoB, transmembrane SPH21_RS20085 0b6ad073908753731bf0ab4d92cf3e34 177 SUPERFAMILY SSF160574 61 155 8.37E-5 T 21-04-2016 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 SUPERFAMILY SSF52518 103 507 1.63E-80 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 Pfam PF00676 Dehydrogenase E1 component 188 506 1.9E-53 T 21-04-2016 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 Gene3D G3DSA:3.40.50.970 136 522 9.7E-70 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 SUPERFAMILY SSF52518 570 777 4.29E-47 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 PANTHER PTHR23152 5 922 0.0 T 21-04-2016 IPR011603 2-oxoglutarate dehydrogenase E1 component GO:0004591|GO:0006099|GO:0030976|GO:0055114 KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 SMART SM00861 578 771 3.6E-51 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 TIGRFAM TIGR00239 2oxo_dh_E1: oxoglutarate dehydrogenase (succinyl-transferring), E1 component 6 911 0.0 T 21-04-2016 IPR011603 2-oxoglutarate dehydrogenase E1 component GO:0004591|GO:0006099|GO:0030976|GO:0055114 KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 PANTHER PTHR23152:SF4 5 922 0.0 T 21-04-2016 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 PIRSF PIRSF000157 1 915 0.0 T 21-04-2016 IPR011603 2-oxoglutarate dehydrogenase E1 component GO:0004591|GO:0006099|GO:0030976|GO:0055114 KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 Pfam PF16870 2-oxoglutarate dehydrogenase C-terminal 776 913 3.2E-44 T 21-04-2016 IPR031717 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 Gene3D G3DSA:3.40.50.970 590 782 1.6E-23 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 Pfam PF16078 2-oxoglutarate dehydrogenase N-terminus 5 43 3.1E-13 T 21-04-2016 IPR032106 2-oxoglutarate dehydrogenase E1 component, N-terminal domain KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SPH21_RS08335 51bb679a0ca834e9bfea41a9d8efa5c6 937 Pfam PF02779 Transketolase, pyrimidine binding domain 578 772 9.0E-62 T 21-04-2016 IPR005475 Transketolase-like, pyrimidine-binding domain SPH21_RS03750 3738c644e9ad7fd7db098e8aa3e16392 487 SUPERFAMILY SSF141523 257 311 2.88E-18 T 21-04-2016 SPH21_RS03750 3738c644e9ad7fd7db098e8aa3e16392 487 SUPERFAMILY SSF141523 365 414 2.88E-18 T 21-04-2016 SPH21_RS03750 3738c644e9ad7fd7db098e8aa3e16392 487 PANTHER PTHR41533:SF1 240 484 5.9E-61 T 21-04-2016 SPH21_RS03750 3738c644e9ad7fd7db098e8aa3e16392 487 Gene3D G3DSA:2.40.440.10 255 302 1.5E-11 T 21-04-2016 SPH21_RS03750 3738c644e9ad7fd7db098e8aa3e16392 487 Gene3D G3DSA:2.40.440.10 367 414 1.5E-11 T 21-04-2016 SPH21_RS03750 3738c644e9ad7fd7db098e8aa3e16392 487 Pfam PF03734 L,D-transpeptidase catalytic domain 257 421 6.3E-29 T 21-04-2016 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 UniPathway: UPA00219 SPH21_RS03750 3738c644e9ad7fd7db098e8aa3e16392 487 PANTHER PTHR41533 240 484 5.9E-61 T 21-04-2016 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 Gene3D G3DSA:1.10.10.10 120 177 2.4E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 26 175 3.0E-26 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 SUPERFAMILY SSF88946 7 109 5.1E-21 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 Pfam PF04542 Sigma-70 region 2 27 93 2.0E-11 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 PANTHER PTHR30173:SF21 1 178 2.0E-40 T 21-04-2016 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 SUPERFAMILY SSF88659 115 177 1.27E-13 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 Pfam PF08281 Sigma-70, region 4 120 172 2.0E-12 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 PANTHER PTHR30173 1 178 2.0E-40 T 21-04-2016 SPH21_RS05350 70e5fcd929375cc69cd62cd892fbcfd0 178 Gene3D G3DSA:1.10.1740.10 9 112 4.9E-25 T 21-04-2016 SPH21_RS08400 1a6af6e34b42bb94b41cef569005b986 450 PANTHER PTHR30026:SF6 4 444 2.2E-44 T 21-04-2016 SPH21_RS08400 1a6af6e34b42bb94b41cef569005b986 450 PANTHER PTHR30026 4 444 2.2E-44 T 21-04-2016 SPH21_RS08400 1a6af6e34b42bb94b41cef569005b986 450 SUPERFAMILY SSF56954 2 442 1.44E-73 T 21-04-2016 SPH21_RS08400 1a6af6e34b42bb94b41cef569005b986 450 Gene3D G3DSA:1.20.1600.10 22 442 3.8E-67 T 21-04-2016 SPH21_RS08400 1a6af6e34b42bb94b41cef569005b986 450 Pfam PF02321 Outer membrane efflux protein 28 229 3.3E-24 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS08400 1a6af6e34b42bb94b41cef569005b986 450 Pfam PF02321 Outer membrane efflux protein 269 438 2.0E-25 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS09650 b46512ea521d6bd7f44703d32f7bb154 192 SUPERFAMILY SSF51161 23 180 4.16E-36 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS09650 b46512ea521d6bd7f44703d32f7bb154 192 PANTHER PTHR23416:SF36 18 192 3.7E-43 T 21-04-2016 SPH21_RS09650 b46512ea521d6bd7f44703d32f7bb154 192 PANTHER PTHR23416 18 192 3.7E-43 T 21-04-2016 SPH21_RS09650 b46512ea521d6bd7f44703d32f7bb154 192 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 127 161 3.8E-6 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS09650 b46512ea521d6bd7f44703d32f7bb154 192 Gene3D G3DSA:2.160.10.10 9 180 6.1E-39 T 21-04-2016 SPH21_RS06735 e44f880f434370d1d0d5a095a50ceb4d 225 PANTHER PTHR35809 2 222 7.5E-65 T 21-04-2016 SPH21_RS06735 e44f880f434370d1d0d5a095a50ceb4d 225 Pfam PF02666 Phosphatidylserine decarboxylase 51 214 1.5E-32 T 21-04-2016 IPR003817 Phosphatidylserine decarboxylase-related GO:0004609|GO:0008654 KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669|UniPathway: UPA00558 SPH21_RS06735 e44f880f434370d1d0d5a095a50ceb4d 225 TIGRFAM TIGR00164 PS_decarb_rel: phosphatidylserine decarboxylase homolog 39 218 8.3E-53 T 21-04-2016 IPR033175 Phosphatidylserine decarboxylase, archaeal-type KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669|UniPathway: UPA00558 SPH21_RS06735 e44f880f434370d1d0d5a095a50ceb4d 225 Hamap MF_00664 Phosphatidylserine decarboxylase proenzyme [psd]. 2 219 32.513 T 21-04-2016 IPR033175 Phosphatidylserine decarboxylase, archaeal-type KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669|UniPathway: UPA00558 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 Gene3D G3DSA:1.20.1610.10 499 629 3.0E-45 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 PANTHER PTHR12143:SF22 446 773 4.2E-147 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 PANTHER PTHR12143:SF22 11 253 4.2E-147 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 PANTHER PTHR12143:SF22 282 428 4.2E-147 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 Gene3D G3DSA:3.30.2080.10 630 773 8.5E-51 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 Gene3D G3DSA:1.20.1050.60 404 491 5.3E-25 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 SUPERFAMILY SSF48208 319 768 1.28E-22 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 PANTHER PTHR12143 446 773 4.2E-147 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 PANTHER PTHR12143 11 253 4.2E-147 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 PANTHER PTHR12143 282 428 4.2E-147 T 21-04-2016 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 Gene3D G3DSA:2.70.98.10 31 379 5.2E-101 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 Pfam PF07971 Glycosyl hydrolase family 92 296 770 1.8E-148 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS21310 8751c764be9b6d805339c4e73ad1759b 774 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 14 773 1.6E-166 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS15445 6b7ab39529661d9941151aaf671db199 400 PANTHER PTHR23517 1 400 8.9E-47 T 21-04-2016 SPH21_RS15445 6b7ab39529661d9941151aaf671db199 400 Gene3D G3DSA:1.20.1250.20 216 397 2.9E-19 T 21-04-2016 SPH21_RS15445 6b7ab39529661d9941151aaf671db199 400 Gene3D G3DSA:1.20.1250.20 20 201 1.6E-29 T 21-04-2016 SPH21_RS15445 6b7ab39529661d9941151aaf671db199 400 Pfam PF07690 Major Facilitator Superfamily 23 317 1.6E-35 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS15445 6b7ab39529661d9941151aaf671db199 400 SUPERFAMILY SSF103473 17 399 7.46E-54 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS07900 379cf17c8bcca8e769b5a8678770fed7 165 Pfam PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 15 157 6.3E-34 T 21-04-2016 IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 GO:0008137|GO:0055114 SPH21_RS07900 379cf17c8bcca8e769b5a8678770fed7 165 PANTHER PTHR33269 3 163 1.3E-40 T 21-04-2016 SPH21_RS07900 379cf17c8bcca8e769b5a8678770fed7 165 PANTHER PTHR33269:SF1 3 163 1.3E-40 T 21-04-2016 SPH21_RS09190 b022a399471d88db753de0cd64b1a264 369 Pfam PF06580 Histidine kinase 173 247 8.2E-11 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS09190 b022a399471d88db753de0cd64b1a264 369 PANTHER PTHR34220 51 362 5.6E-18 T 21-04-2016 SPH21_RS05720 d9410d19ec6a86bee19b4a38cec43a7b 410 SUPERFAMILY SSF63411 3 209 6.0E-53 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS05720 d9410d19ec6a86bee19b4a38cec43a7b 410 Gene3D G3DSA:3.30.830.10 227 398 2.3E-38 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS05720 d9410d19ec6a86bee19b4a38cec43a7b 410 Gene3D G3DSA:3.30.830.10 4 211 3.5E-51 T 21-04-2016 IPR011237 Peptidase M16 domain GO:0046872 SPH21_RS05720 d9410d19ec6a86bee19b4a38cec43a7b 410 Pfam PF00675 Insulinase (Peptidase family M16) 18 159 2.6E-32 T 21-04-2016 IPR011765 Peptidase M16, N-terminal SPH21_RS05720 d9410d19ec6a86bee19b4a38cec43a7b 410 SUPERFAMILY SSF63411 230 400 1.0E-32 T 21-04-2016 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SPH21_RS05720 d9410d19ec6a86bee19b4a38cec43a7b 410 PANTHER PTHR11851 5 397 3.4E-91 T 21-04-2016 SPH21_RS05720 d9410d19ec6a86bee19b4a38cec43a7b 410 Pfam PF05193 Peptidase M16 inactive domain 166 340 7.8E-26 T 21-04-2016 IPR007863 Peptidase M16, C-terminal SPH21_RS05060 cf0a4b4bfbed0d0a3b7032e48a32fb40 235 Gene3D G3DSA:3.40.225.10 7 234 1.0E-64 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS05060 cf0a4b4bfbed0d0a3b7032e48a32fb40 235 SUPERFAMILY SSF53639 7 226 4.12E-64 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS05060 cf0a4b4bfbed0d0a3b7032e48a32fb40 235 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 17 201 1.5E-41 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS05060 cf0a4b4bfbed0d0a3b7032e48a32fb40 235 PANTHER PTHR22789 1 234 5.0E-98 T 21-04-2016 SPH21_RS05060 cf0a4b4bfbed0d0a3b7032e48a32fb40 235 PANTHER PTHR22789:SF8 1 234 5.0E-98 T 21-04-2016 SPH21_RS05060 cf0a4b4bfbed0d0a3b7032e48a32fb40 235 SMART SM01007 11 201 3.8E-57 T 21-04-2016 IPR001303 Class II aldolase/adducin N-terminal SPH21_RS10655 d2aa716fc779175fedd806bffbf1085d 428 PANTHER PTHR10361 299 428 7.0E-54 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS10655 d2aa716fc779175fedd806bffbf1085d 428 PANTHER PTHR10361 60 231 7.0E-54 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS10655 d2aa716fc779175fedd806bffbf1085d 428 Pfam PF01758 Sodium Bile acid symporter family 91 233 8.2E-28 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS10655 d2aa716fc779175fedd806bffbf1085d 428 PANTHER PTHR10361:SF28 299 428 7.0E-54 T 21-04-2016 SPH21_RS10655 d2aa716fc779175fedd806bffbf1085d 428 PANTHER PTHR10361:SF28 60 231 7.0E-54 T 21-04-2016 SPH21_RS07345 c1b8cab0e8447974169d51cdf62e413e 229 Gene3D G3DSA:3.40.50.150 28 227 7.0E-66 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS07345 c1b8cab0e8447974169d51cdf62e413e 229 SUPERFAMILY SSF53335 20 225 1.55E-50 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS07345 c1b8cab0e8447974169d51cdf62e413e 229 Hamap MF_00090 Protein-L-isoaspartate O-methyltransferase [pcm]. 19 229 36.201 T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS07345 c1b8cab0e8447974169d51cdf62e413e 229 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 26 227 6.6E-69 T 21-04-2016 SPH21_RS07345 c1b8cab0e8447974169d51cdf62e413e 229 TIGRFAM TIGR00080 pimt: protein-L-isoaspartate O-methyltransferase 25 228 8.1E-70 T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS07345 c1b8cab0e8447974169d51cdf62e413e 229 ProSitePatterns PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 150 165 - T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS07345 c1b8cab0e8447974169d51cdf62e413e 229 PANTHER PTHR11579 30 229 8.3E-81 T 21-04-2016 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SPH21_RS12975 b45f6c4b5fddf73dadc44e84df3b9da0 269 SUPERFAMILY SSF52518 10 267 1.1E-73 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS12975 b45f6c4b5fddf73dadc44e84df3b9da0 269 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 21 259 2.8E-43 T 21-04-2016 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560|UniPathway: UPA00064 SPH21_RS12975 b45f6c4b5fddf73dadc44e84df3b9da0 269 Gene3D G3DSA:3.40.50.970 10 268 4.6E-86 T 21-04-2016 IPR029061 Thiamin diphosphate-binding fold SPH21_RS12975 b45f6c4b5fddf73dadc44e84df3b9da0 269 PANTHER PTHR11624:SF86 2 268 7.0E-91 T 21-04-2016 SPH21_RS12975 b45f6c4b5fddf73dadc44e84df3b9da0 269 PANTHER PTHR11624 2 268 7.0E-91 T 21-04-2016 IPR033247 Transketolase family SPH21_RS09970 be77b87d336f03b10797b14210cae27c 124 Gene3D G3DSA:1.10.260.40 4 58 7.1E-8 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS09970 be77b87d336f03b10797b14210cae27c 124 SUPERFAMILY SSF47413 3 61 5.85E-7 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS09970 be77b87d336f03b10797b14210cae27c 124 Pfam PF01381 Helix-turn-helix 12 55 5.0E-5 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS15070 9efc5fff0b9e7e8bb9894b6de830b420 841 PANTHER PTHR11532 1 104 3.8E-24 T 21-04-2016 SPH21_RS15070 9efc5fff0b9e7e8bb9894b6de830b420 841 Gene3D G3DSA:2.60.40.1120 18 90 2.6E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS15070 9efc5fff0b9e7e8bb9894b6de830b420 841 Pfam PF13715 CarboxypepD_reg-like domain 18 102 1.3E-18 T 21-04-2016 SPH21_RS15070 9efc5fff0b9e7e8bb9894b6de830b420 841 PANTHER PTHR11532:SF57 1 104 3.8E-24 T 21-04-2016 SPH21_RS15070 9efc5fff0b9e7e8bb9894b6de830b420 841 SUPERFAMILY SSF49464 17 100 6.67E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 PANTHER PTHR11061 13 476 8.7E-152 T 21-04-2016 SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 SUPERFAMILY SSF50249 7 63 5.14E-11 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 Pfam PF01938 TRAM domain 16 62 1.2E-6 T 21-04-2016 IPR002792 TRAM domain SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 ProSitePatterns PS01230 RNA methyltransferase trmA family signature 1. 406 437 - T 21-04-2016 IPR030390 RNA methyltransferase TrmA, active site SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 Gene3D G3DSA:2.40.50.140 2 83 2.2E-24 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 Pfam PF05958 tRNA (Uracil-5-)-methyltransferase 223 473 1.2E-19 T 21-04-2016 IPR010280 (Uracil-5)-methyltransferase family GO:0006396|GO:0008173 SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 PANTHER PTHR11061:SF30 13 476 8.7E-152 T 21-04-2016 SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 Gene3D G3DSA:3.40.50.150 262 473 8.7E-57 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 SUPERFAMILY SSF53335 72 473 3.82E-62 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 ProSitePatterns PS01231 RNA methyltransferase trmA family signature 2. 457 467 - T 21-04-2016 IPR030391 RNA methyltransferase TrmA, conserved site SPH21_RS06145 88814dad1c9399507bed08ee916ed7cd 476 TIGRFAM TIGR00479 rumA: 23S rRNA (uracil-5-)-methyltransferase RumA 22 467 7.6E-108 T 21-04-2016 IPR001566 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD GO:0003723|GO:0006396|GO:0008173 SPH21_RS10590 6e7d481fe63886daefa6917a1d124997 346 PANTHER PTHR35008:SF4 83 307 4.2E-39 T 21-04-2016 SPH21_RS10590 6e7d481fe63886daefa6917a1d124997 346 Gene3D G3DSA:1.10.760.10 46 193 5.0E-26 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS10590 6e7d481fe63886daefa6917a1d124997 346 Gene3D G3DSA:1.10.760.10 209 310 3.5E-15 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS10590 6e7d481fe63886daefa6917a1d124997 346 Pfam PF00034 Cytochrome c 215 302 1.3E-9 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS10590 6e7d481fe63886daefa6917a1d124997 346 SUPERFAMILY SSF46626 208 310 2.01E-18 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS10590 6e7d481fe63886daefa6917a1d124997 346 SUPERFAMILY SSF46626 101 193 1.44E-22 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS10590 6e7d481fe63886daefa6917a1d124997 346 PANTHER PTHR35008 83 307 4.2E-39 T 21-04-2016 SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 SMART SM00382 26 228 8.2E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 SUPERFAMILY SSF52540 2 237 2.98E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 Gene3D G3DSA:3.40.50.300 1 271 1.2E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 Gene3D G3DSA:3.40.50.300 319 534 2.1E-25 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 PANTHER PTHR19211:SF38 1 539 0.0 T 21-04-2016 SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 PANTHER PTHR19211 1 539 0.0 T 21-04-2016 SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 SUPERFAMILY SSF52540 230 290 2.77E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 SUPERFAMILY SSF52540 398 515 2.77E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 Pfam PF12848 ABC transporter 223 307 5.1E-21 T 21-04-2016 IPR032781 ABC-transporter extension domain SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 Pfam PF00005 ABC transporter 337 469 7.6E-9 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS12205 e40a9ef46bfe47e5693f52f48592445a 540 Pfam PF00005 ABC transporter 18 184 1.7E-23 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS22235 736150465393c7faab81ec44ac9d49bb 288 PANTHER PTHR20858 1 283 2.1E-105 T 21-04-2016 SPH21_RS22235 736150465393c7faab81ec44ac9d49bb 288 PANTHER PTHR20858:SF17 1 283 2.1E-105 T 21-04-2016 SPH21_RS22235 736150465393c7faab81ec44ac9d49bb 288 Pfam PF08543 Phosphomethylpyrimidine kinase 17 263 3.0E-84 T 21-04-2016 IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase UniPathway: UPA00647 SPH21_RS22235 736150465393c7faab81ec44ac9d49bb 288 TIGRFAM TIGR00097 HMP-P_kinase: hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 10 266 2.4E-87 T 21-04-2016 IPR004399 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase GO:0008972|GO:0009228 KEGG: 00730+2.7.1.49|MetaCyc: PWY-6910|MetaCyc: PWY-7356|MetaCyc: PWY-7357 SPH21_RS22235 736150465393c7faab81ec44ac9d49bb 288 Gene3D G3DSA:3.40.1190.20 8 266 2.0E-93 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS22235 736150465393c7faab81ec44ac9d49bb 288 SUPERFAMILY SSF53613 6 267 7.48E-74 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS26065 375f76b925dd86dfb3203e773b88dcd5 370 TIGRFAM TIGR03891 thiopep_ocin: thiopeptide-type bacteriocin biosynthesis domain 121 361 7.7E-36 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS26065 375f76b925dd86dfb3203e773b88dcd5 370 Pfam PF14028 Lantibiotic biosynthesis dehydratase C-term 121 357 8.1E-26 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS10375 3c332c2513b721ab671d00ec81c3feb5 196 PANTHER PTHR24567 26 189 5.8E-29 T 21-04-2016 SPH21_RS10375 3c332c2513b721ab671d00ec81c3feb5 196 Pfam PF00027 Cyclic nucleotide-binding domain 31 116 5.0E-11 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS10375 3c332c2513b721ab671d00ec81c3feb5 196 SUPERFAMILY SSF51206 17 143 9.43E-23 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS10375 3c332c2513b721ab671d00ec81c3feb5 196 Gene3D G3DSA:2.60.120.10 3 157 4.7E-39 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS10375 3c332c2513b721ab671d00ec81c3feb5 196 PANTHER PTHR24567:SF33 26 189 5.8E-29 T 21-04-2016 SPH21_RS18790 fdefeec1dc20627b717fb9866509c275 202 Pfam PF02308 MgtC family 5 123 6.0E-37 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS18790 fdefeec1dc20627b717fb9866509c275 202 PRINTS PR01837 MgtC/SapB protein signature 77 101 7.5E-38 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS18790 fdefeec1dc20627b717fb9866509c275 202 PRINTS PR01837 MgtC/SapB protein signature 7 26 7.5E-38 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS18790 fdefeec1dc20627b717fb9866509c275 202 PRINTS PR01837 MgtC/SapB protein signature 50 72 7.5E-38 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS18790 fdefeec1dc20627b717fb9866509c275 202 PRINTS PR01837 MgtC/SapB protein signature 26 44 7.5E-38 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS18790 fdefeec1dc20627b717fb9866509c275 202 PANTHER PTHR33778 1 201 1.5E-45 T 21-04-2016 SPH21_RS21680 0823e95c5aa52dac213d047c5a276937 295 Pfam PF03279 Bacterial lipid A biosynthesis acyltransferase 17 290 7.9E-36 T 21-04-2016 IPR004960 Bacterial lipid A biosynthesis acyltransferase GO:0016021|GO:0016740 SPH21_RS21680 0823e95c5aa52dac213d047c5a276937 295 PANTHER PTHR30606 4 290 1.9E-40 T 21-04-2016 SPH21_RS21680 0823e95c5aa52dac213d047c5a276937 295 PANTHER PTHR30606:SF2 4 290 1.9E-40 T 21-04-2016 SPH21_RS18765 b60dd7ed06c55e78524397b72eea4dcd 397 PANTHER PTHR30605 11 376 5.5E-117 T 21-04-2016 SPH21_RS18765 b60dd7ed06c55e78524397b72eea4dcd 397 SUPERFAMILY SSF53067 19 56 3.08E-18 T 21-04-2016 SPH21_RS18765 b60dd7ed06c55e78524397b72eea4dcd 397 SUPERFAMILY SSF53067 83 128 3.08E-18 T 21-04-2016 SPH21_RS18765 b60dd7ed06c55e78524397b72eea4dcd 397 SUPERFAMILY SSF53067 166 350 3.08E-18 T 21-04-2016 SPH21_RS18765 b60dd7ed06c55e78524397b72eea4dcd 397 Hamap MF_01270 Anhydro-N-acetylmuramic acid kinase [anmK]. 17 396 33.194 T 21-04-2016 IPR005338 Anhydro-N-acetylmuramic acid kinase GO:0005524|GO:0006040|GO:0009254|GO:0016773 KEGG: 00040+2.7.1.17|UniPathway: UPA00343|UniPathway: UPA00544 SPH21_RS18765 b60dd7ed06c55e78524397b72eea4dcd 397 Gene3D G3DSA:3.30.420.40 18 221 2.1E-60 T 21-04-2016 SPH21_RS18765 b60dd7ed06c55e78524397b72eea4dcd 397 Pfam PF03702 Uncharacterised protein family (UPF0075) 19 384 3.6E-96 T 21-04-2016 IPR005338 Anhydro-N-acetylmuramic acid kinase GO:0005524|GO:0006040|GO:0009254|GO:0016773 KEGG: 00040+2.7.1.17|UniPathway: UPA00343|UniPathway: UPA00544 SPH21_RS23175 4854ea58e66418ac09716312d361815f 412 SUPERFAMILY SSF48208 47 408 2.04E-99 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS23175 4854ea58e66418ac09716312d361815f 412 PANTHER PTHR36845 50 406 7.8E-92 T 21-04-2016 SPH21_RS23175 4854ea58e66418ac09716312d361815f 412 PANTHER PTHR36845:SF1 50 406 7.8E-92 T 21-04-2016 SPH21_RS23175 4854ea58e66418ac09716312d361815f 412 Pfam PF07470 Glycosyl Hydrolase Family 88 63 406 1.3E-26 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS23175 4854ea58e66418ac09716312d361815f 412 Gene3D G3DSA:1.50.10.10 27 409 1.2E-141 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 PIRSF PIRSF005900 1 159 3.0E-45 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 Gene3D G3DSA:1.20.1260.10 3 158 7.2E-54 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 134 152 6.2E-13 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 38 54 6.2E-13 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 62 78 6.2E-13 T 21-04-2016 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 PANTHER PTHR30295 1 159 3.6E-51 T 21-04-2016 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 SUPERFAMILY SSF47240 4 158 5.8E-42 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 PANTHER PTHR30295:SF6 1 159 3.6E-51 T 21-04-2016 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 ProSitePatterns PS00819 Dps protein family signature 2. 64 78 - T 21-04-2016 IPR023188 DNA-binding protein Dps, conserved site GO:0016722|GO:0055114 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 ProSitePatterns PS00818 Dps protein family signature 1. 38 54 - T 21-04-2016 IPR023188 DNA-binding protein Dps, conserved site GO:0016722|GO:0055114 SPH21_RS22985 6ae5799028ea87dde6c17d4b08954cec 159 Pfam PF00210 Ferritin-like domain 18 158 9.7E-26 T 21-04-2016 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 SPH21_RS20055 9cd110c1dd067c06214dde87cb47c4d8 196 SUPERFAMILY SSF55144 13 181 2.96E-10 T 21-04-2016 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SPH21_RS20055 9cd110c1dd067c06214dde87cb47c4d8 196 Gene3D G3DSA:3.90.1140.10 15 186 2.8E-6 T 21-04-2016 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SPH21_RS23295 bce91e88da1764eef75ef6b9054eb8c7 346 SUPERFAMILY SSF53187 44 344 2.78E-40 T 21-04-2016 SPH21_RS23295 bce91e88da1764eef75ef6b9054eb8c7 346 PANTHER PTHR37326 48 344 1.8E-48 T 21-04-2016 SPH21_RS23295 bce91e88da1764eef75ef6b9054eb8c7 346 Pfam PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 61 343 2.2E-39 T 21-04-2016 IPR007036 Succinylglutamate desuccinylase/aspartoacylase GO:0008152|GO:0016788 SPH21_RS23295 bce91e88da1764eef75ef6b9054eb8c7 346 PANTHER PTHR37326:SF1 48 344 1.8E-48 T 21-04-2016 SPH21_RS23295 bce91e88da1764eef75ef6b9054eb8c7 346 Gene3D G3DSA:1.10.3540.10 242 290 3.0E-4 T 21-04-2016 IPR023137 DUF1819 domain SPH21_RS23295 bce91e88da1764eef75ef6b9054eb8c7 346 Gene3D G3DSA:3.40.630.10 50 241 2.2E-18 T 21-04-2016 SPH21_RS23295 bce91e88da1764eef75ef6b9054eb8c7 346 PIRSF PIRSF039012 24 346 1.4E-80 T 21-04-2016 IPR007036 Succinylglutamate desuccinylase/aspartoacylase GO:0008152|GO:0016788 SPH21_RS00845 feead75e9913fed1d040ec2b37448b6a 204 Pfam PF05076 Suppressor of fused protein (SUFU) 43 200 6.4E-30 T 21-04-2016 IPR020941 Suppressor of fused-like domain SPH21_RS00845 feead75e9913fed1d040ec2b37448b6a 204 ProDom PD105609 PLASMID YQCF RSP1132 19 203 3.0E-31 T 21-04-2016 SPH21_RS05795 6f12bc38469e6d97890c2b145a6b1272 814 Pfam PF12704 MacB-like periplasmic core domain 20 255 4.7E-14 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05795 6f12bc38469e6d97890c2b145a6b1272 814 Pfam PF02687 FtsX-like permease family 698 806 1.2E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05795 6f12bc38469e6d97890c2b145a6b1272 814 Pfam PF02687 FtsX-like permease family 305 421 5.3E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05795 6f12bc38469e6d97890c2b145a6b1272 814 PANTHER PTHR30572 425 814 1.2E-67 T 21-04-2016 SPH21_RS05795 6f12bc38469e6d97890c2b145a6b1272 814 PANTHER PTHR30572 302 370 1.2E-67 T 21-04-2016 SPH21_RS05795 6f12bc38469e6d97890c2b145a6b1272 814 PANTHER PTHR30572:SF4 425 814 1.2E-67 T 21-04-2016 SPH21_RS05795 6f12bc38469e6d97890c2b145a6b1272 814 PANTHER PTHR30572:SF4 302 370 1.2E-67 T 21-04-2016 SPH21_RS23945 e3588c44a91d77bb38a79c46d6677c86 364 PANTHER PTHR22893 11 359 2.6E-155 T 21-04-2016 SPH21_RS23945 e3588c44a91d77bb38a79c46d6677c86 364 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 10 339 2.8E-80 T 21-04-2016 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SPH21_RS23945 e3588c44a91d77bb38a79c46d6677c86 364 PANTHER PTHR22893:SF14 11 359 2.6E-155 T 21-04-2016 SPH21_RS23945 e3588c44a91d77bb38a79c46d6677c86 364 SUPERFAMILY SSF51395 3 361 2.03E-114 T 21-04-2016 SPH21_RS23945 e3588c44a91d77bb38a79c46d6677c86 364 Gene3D G3DSA:3.20.20.70 2 360 3.4E-123 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS11560 0d5be602b620dadb470bc0cfb76a9849 356 Gene3D G3DSA:3.30.360.10 152 264 1.2E-14 T 21-04-2016 SPH21_RS11560 0d5be602b620dadb470bc0cfb76a9849 356 Gene3D G3DSA:3.30.360.10 304 348 1.2E-14 T 21-04-2016 SPH21_RS11560 0d5be602b620dadb470bc0cfb76a9849 356 PANTHER PTHR22604 10 355 7.9E-33 T 21-04-2016 SPH21_RS11560 0d5be602b620dadb470bc0cfb76a9849 356 Gene3D G3DSA:3.40.50.720 9 151 1.9E-25 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11560 0d5be602b620dadb470bc0cfb76a9849 356 SUPERFAMILY SSF51735 7 161 6.2E-25 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11560 0d5be602b620dadb470bc0cfb76a9849 356 SUPERFAMILY SSF55347 139 273 4.25E-11 T 21-04-2016 SPH21_RS11560 0d5be602b620dadb470bc0cfb76a9849 356 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 16 130 2.2E-10 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 Gene3D G3DSA:3.60.15.10 17 263 2.0E-52 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 Pfam PF00581 Rhodanese-like domain 380 468 4.0E-19 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 Pfam PF00581 Rhodanese-like domain 283 342 3.3E-5 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 PANTHER PTHR11935:SF9 11 263 3.9E-77 T 21-04-2016 SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 Gene3D G3DSA:3.40.250.10 370 475 1.7E-30 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 SUPERFAMILY SSF56281 24 263 3.78E-41 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 SUPERFAMILY SSF52821 375 474 1.57E-29 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 SMART SM00450 377 472 8.6E-26 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 Gene3D G3DSA:3.40.250.10 278 358 6.2E-9 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 SMART SM00849 24 203 1.5E-20 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 SUPERFAMILY SSF52821 254 356 2.75E-10 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 Pfam PF00753 Metallo-beta-lactamase superfamily 26 171 4.8E-8 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS17900 70bf1cecdac7da2418c9545e2fec9c06 475 PANTHER PTHR11935 11 263 3.9E-77 T 21-04-2016 SPH21_RS16120 cea23692ac422a5374b189df14ab71f4 362 PANTHER PTHR12526 69 344 7.0E-52 T 21-04-2016 SPH21_RS16120 cea23692ac422a5374b189df14ab71f4 362 PANTHER PTHR12526 1 46 7.0E-52 T 21-04-2016 SPH21_RS16120 cea23692ac422a5374b189df14ab71f4 362 Gene3D G3DSA:3.40.50.2000 166 317 7.4E-21 T 21-04-2016 SPH21_RS16120 cea23692ac422a5374b189df14ab71f4 362 Pfam PF13439 Glycosyltransferase Family 4 18 139 2.3E-15 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS16120 cea23692ac422a5374b189df14ab71f4 362 Pfam PF00534 Glycosyl transferases group 1 167 307 5.5E-28 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS16120 cea23692ac422a5374b189df14ab71f4 362 SUPERFAMILY SSF53756 10 341 2.36E-64 T 21-04-2016 SPH21_RS16210 2d9efda712968518961379c4712dc248 396 Pfam PF07786 Protein of unknown function (DUF1624) 4 163 3.4E-8 T 21-04-2016 IPR012429 Protein of unknown function DUF1624 KEGG: 00531+2.3.1.78 SPH21_RS16210 2d9efda712968518961379c4712dc248 396 PANTHER PTHR31061 374 396 6.4E-56 T 21-04-2016 SPH21_RS16210 2d9efda712968518961379c4712dc248 396 PANTHER PTHR31061 2 352 6.4E-56 T 21-04-2016 SPH21_RS06935 ef8ae89dda464fb62b3702cd3a4df412 171 Pfam PF10652 Protein of unknown function (DUF2480) 5 169 1.8E-72 T 21-04-2016 IPR018914 Protein of unknown function DUF2480 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 Pfam PF00884 Sulfatase 35 396 9.9E-57 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 PANTHER PTHR10342:SF207 288 492 9.8E-146 T 21-04-2016 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 PANTHER PTHR10342:SF207 6 265 9.8E-146 T 21-04-2016 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 Gene3D G3DSA:3.30.1120.10 435 495 1.5E-9 T 21-04-2016 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 Gene3D G3DSA:3.40.720.10 32 419 1.2E-97 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 PANTHER PTHR10342 288 492 9.8E-146 T 21-04-2016 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 PANTHER PTHR10342 6 265 9.8E-146 T 21-04-2016 SPH21_RS20890 32e563e851ae9be7549956c97f0f8c17 503 SUPERFAMILY SSF53649 33 495 1.31E-111 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS18770 166422f6ca5f790e1d5a565370c95d39 756 Pfam PF03572 Peptidase family S41 627 723 1.2E-11 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS18770 166422f6ca5f790e1d5a565370c95d39 756 Gene3D G3DSA:3.90.226.10 569 750 7.1E-24 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18770 166422f6ca5f790e1d5a565370c95d39 756 SUPERFAMILY SSF52096 362 433 3.81E-22 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18770 166422f6ca5f790e1d5a565370c95d39 756 SUPERFAMILY SSF52096 639 749 3.81E-22 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18770 166422f6ca5f790e1d5a565370c95d39 756 SUPERFAMILY SSF52096 536 608 3.81E-22 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS24485 fea8e24feefe7726fbf02a327824bbdc 197 Pfam PF10543 ORF6N domain 21 106 2.5E-32 T 21-04-2016 IPR018873 KilA-N, DNA-binding domain SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 PANTHER PTHR11907 46 89 3.1E-72 T 21-04-2016 SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 PANTHER PTHR11907 401 523 3.1E-72 T 21-04-2016 SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 PANTHER PTHR11907 108 384 3.1E-72 T 21-04-2016 SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 PANTHER PTHR11907:SF0 46 89 3.1E-72 T 21-04-2016 SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 PANTHER PTHR11907:SF0 401 523 3.1E-72 T 21-04-2016 SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 PANTHER PTHR11907:SF0 108 384 3.1E-72 T 21-04-2016 SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 SUPERFAMILY SSF53271 426 523 4.54E-15 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 SUPERFAMILY SSF53271 320 395 4.54E-15 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 Pfam PF13230 Glutamine amidotransferases class-II 111 169 2.2E-5 T 21-04-2016 IPR026869 Putative glutamine amidotransferase type 2 SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 Gene3D G3DSA:3.40.50.2020 336 398 6.6E-18 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 Gene3D G3DSA:3.40.50.2020 452 523 6.6E-18 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 SUPERFAMILY SSF56235 33 60 4.12E-39 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 SUPERFAMILY SSF56235 96 326 4.12E-39 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS10895 5d0c41decf5c717580dbe58cb0512d71 636 Gene3D G3DSA:3.60.20.10 8 309 9.8E-53 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 Pfam PF00571 CBS domain 94 143 2.9E-4 T 21-04-2016 IPR000644 CBS domain SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 Pfam PF00571 CBS domain 27 75 1.9E-7 T 21-04-2016 IPR000644 CBS domain SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 SUPERFAMILY SSF54631 23 144 2.2E-24 T 21-04-2016 SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 Pfam PF03445 Putative nucleotidyltransferase DUF294 170 306 7.8E-47 T 21-04-2016 IPR005105 Protein-PII uridylyltransferase, N-terminal GO:0008773 SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 SMART SM00116 33 81 0.019 T 21-04-2016 IPR000644 CBS domain SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 SMART SM00116 98 145 4.0 T 21-04-2016 IPR000644 CBS domain SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 Pfam PF10335 Putative nucleotidyltransferase substrate binding domain 347 489 9.1E-34 T 21-04-2016 IPR018821 Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding SPH21_RS25225 1a059c193fdb54c19d24ae023968c0cb 495 Gene3D G3DSA:3.10.580.10 23 141 4.8E-22 T 21-04-2016 SPH21_RS21185 74649ab381b9f4214120fd914c7414c0 239 PANTHER PTHR11054 2 238 4.5E-87 T 21-04-2016 SPH21_RS21185 74649ab381b9f4214120fd914c7414c0 239 Gene3D G3DSA:3.40.50.1360 2 238 3.5E-76 T 21-04-2016 SPH21_RS21185 74649ab381b9f4214120fd914c7414c0 239 TIGRFAM TIGR01198 pgl: 6-phosphogluconolactonase 4 237 8.8E-67 T 21-04-2016 IPR005900 6-phosphogluconolactonase, DevB-type GO:0005975|GO:0006098|GO:0017057 KEGG: 00030+3.1.1.31|UniPathway: UPA00115 SPH21_RS21185 74649ab381b9f4214120fd914c7414c0 239 Pfam PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 7 228 5.6E-72 T 21-04-2016 IPR006148 Glucosamine/galactosamine-6-phosphate isomerase GO:0005975 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906 SPH21_RS21185 74649ab381b9f4214120fd914c7414c0 239 SUPERFAMILY SSF100950 2 238 1.5E-71 T 21-04-2016 SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 1 211 1.9E-28 T 21-04-2016 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 SUPERFAMILY SSF56300 1 257 1.27E-50 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 PANTHER PTHR11124:SF2 105 255 2.2E-49 T 21-04-2016 SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 PANTHER PTHR11124:SF2 1 72 2.2E-49 T 21-04-2016 SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 PANTHER PTHR11124 105 255 2.2E-49 T 21-04-2016 IPR000979 Phosphodiesterase MJ0936/Vps29 SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 PANTHER PTHR11124 1 72 2.2E-49 T 21-04-2016 IPR000979 Phosphodiesterase MJ0936/Vps29 SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 PIRSF PIRSF000883 1 257 5.3E-54 T 21-04-2016 IPR011152 Phosphoesterase MJ0912 SPH21_RS01120 381ddad262416f73fef26f7bd6e3d24d 257 Gene3D G3DSA:3.60.21.10 1 257 7.4E-75 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS03755 64f392710172f3d0e61e2c268c53e33b 143 TIGRFAM TIGR03511 GldH_lipo: gliding motility-associated lipoprotein GldH 1 135 4.5E-36 T 21-04-2016 IPR020018 Gliding motility-associated lipoprotein, GldH SPH21_RS03755 64f392710172f3d0e61e2c268c53e33b 143 Pfam PF14109 GldH lipoprotein 10 134 1.3E-39 T 21-04-2016 IPR020018 Gliding motility-associated lipoprotein, GldH SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 SUPERFAMILY SSF51735 41 284 1.11E-81 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 229 2.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 246 266 2.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 181 2.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 191 210 2.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 119 130 2.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 44 61 2.9E-36 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 Gene3D G3DSA:3.40.50.720 38 284 6.4E-84 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PANTHER PTHR24322:SF105 47 175 1.6E-67 T 21-04-2016 SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PANTHER PTHR24322:SF105 191 223 1.6E-67 T 21-04-2016 SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 178 206 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 52 281 3.5E-64 T 21-04-2016 SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 191 210 2.2E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 119 130 2.2E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 171 179 2.2E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PANTHER PTHR24322 47 175 1.6E-67 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS10555 b4fc5ed9ccc09a7cfebef882fbc793e8 286 PANTHER PTHR24322 191 223 1.6E-67 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS05300 cc7d0ad1cdfd7ffbef056874444c87ee 317 PANTHER PTHR10366:SF12 4 316 1.3E-92 T 21-04-2016 SPH21_RS05300 cc7d0ad1cdfd7ffbef056874444c87ee 317 Gene3D G3DSA:3.90.25.10 208 315 3.6E-6 T 21-04-2016 SPH21_RS05300 cc7d0ad1cdfd7ffbef056874444c87ee 317 SUPERFAMILY SSF51735 4 314 6.13E-51 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05300 cc7d0ad1cdfd7ffbef056874444c87ee 317 PANTHER PTHR10366 4 316 1.3E-92 T 21-04-2016 SPH21_RS05300 cc7d0ad1cdfd7ffbef056874444c87ee 317 Pfam PF01370 NAD dependent epimerase/dehydratase family 5 233 1.5E-28 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS05300 cc7d0ad1cdfd7ffbef056874444c87ee 317 Gene3D G3DSA:3.40.50.720 4 207 1.4E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 PANTHER PTHR11654 8 255 1.5E-153 T 21-04-2016 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 PANTHER PTHR11654 299 557 1.5E-153 T 21-04-2016 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 TIGRFAM TIGR00924 yjdL_sub1_fam: amino acid/peptide transporter (Peptide:H+ symporter) 17 489 1.6E-86 T 21-04-2016 IPR005279 Dipeptide/tripeptide permease GO:0015197|GO:0015833|GO:0016020 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 ProSitePatterns PS01023 PTR2 family proton/oligopeptide symporters signature 2. 159 171 - T 21-04-2016 IPR018456 PTR2 family proton/oligopeptide symporter, conserved site GO:0005215|GO:0006857|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 Pfam PF00854 POT family 88 478 2.4E-49 T 21-04-2016 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 SUPERFAMILY SSF103473 294 484 1.7E-28 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 SUPERFAMILY SSF103473 14 224 1.7E-28 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 SUPERFAMILY SSF103473 534 556 1.7E-28 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 PANTHER PTHR11654:SF119 8 255 1.5E-153 T 21-04-2016 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 PANTHER PTHR11654:SF119 299 557 1.5E-153 T 21-04-2016 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 Gene3D G3DSA:1.20.1250.20 318 483 4.4E-4 T 21-04-2016 SPH21_RS12230 2b013e85bb41303e2aeb57a44d506376 569 Gene3D G3DSA:1.20.1250.20 25 242 8.7E-20 T 21-04-2016 SPH21_RS08005 7523d1e68b8e85e080d757198ec8082f 303 Hamap MF_00185 tRNA dimethylallyltransferase [miaA]. 7 296 20.616 T 21-04-2016 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781 SPH21_RS08005 7523d1e68b8e85e080d757198ec8082f 303 Gene3D G3DSA:1.10.287.890 198 275 1.8E-17 T 21-04-2016 SPH21_RS08005 7523d1e68b8e85e080d757198ec8082f 303 Pfam PF01715 IPP transferase 40 276 3.6E-51 T 21-04-2016 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781 SPH21_RS08005 7523d1e68b8e85e080d757198ec8082f 303 PANTHER PTHR11088 7 286 1.3E-40 T 21-04-2016 SPH21_RS08005 7523d1e68b8e85e080d757198ec8082f 303 SUPERFAMILY SSF52540 7 132 2.17E-12 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08005 7523d1e68b8e85e080d757198ec8082f 303 Gene3D G3DSA:3.40.50.300 6 166 4.5E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08005 7523d1e68b8e85e080d757198ec8082f 303 TIGRFAM TIGR00174 miaA: tRNA dimethylallyltransferase 8 287 4.1E-54 T 21-04-2016 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781 SPH21_RS06625 882ae796c3a8238fcd91b21e05920eb5 224 PANTHER PTHR36452 1 224 2.6E-43 T 21-04-2016 SPH21_RS06625 882ae796c3a8238fcd91b21e05920eb5 224 PIRSF PIRSF028451 1 224 1.8E-65 T 21-04-2016 IPR015996 Uncharacterised conserved protein UCP028451 SPH21_RS06625 882ae796c3a8238fcd91b21e05920eb5 224 TIGRFAM TIGR02453 TIGR02453: TIGR02453 family protein 5 222 2.8E-66 T 21-04-2016 IPR012808 Conserved hypothetical protein CHP02453 SPH21_RS06625 882ae796c3a8238fcd91b21e05920eb5 224 PANTHER PTHR36452:SF1 1 224 2.6E-43 T 21-04-2016 SPH21_RS06625 882ae796c3a8238fcd91b21e05920eb5 224 Pfam PF09365 Conserved hypothetical protein (DUF2461) 7 213 5.5E-71 T 21-04-2016 IPR012808 Conserved hypothetical protein CHP02453 SPH21_RS06040 1edc1c0d4e4a25c9d0e3a79d6b1f096d 796 PANTHER PTHR30572:SF4 280 353 3.1E-55 T 21-04-2016 SPH21_RS06040 1edc1c0d4e4a25c9d0e3a79d6b1f096d 796 PANTHER PTHR30572:SF4 398 796 3.1E-55 T 21-04-2016 SPH21_RS06040 1edc1c0d4e4a25c9d0e3a79d6b1f096d 796 Pfam PF02687 FtsX-like permease family 288 403 1.2E-14 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06040 1edc1c0d4e4a25c9d0e3a79d6b1f096d 796 Pfam PF02687 FtsX-like permease family 677 788 3.5E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06040 1edc1c0d4e4a25c9d0e3a79d6b1f096d 796 PANTHER PTHR30572 280 353 3.1E-55 T 21-04-2016 SPH21_RS06040 1edc1c0d4e4a25c9d0e3a79d6b1f096d 796 PANTHER PTHR30572 398 796 3.1E-55 T 21-04-2016 SPH21_RS06040 1edc1c0d4e4a25c9d0e3a79d6b1f096d 796 Pfam PF12704 MacB-like periplasmic core domain 422 604 4.2E-13 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS02725 1818bccd90acf338e946db75e09a498d 176 PANTHER PTHR34406:SF1 1 176 9.7E-57 T 21-04-2016 SPH21_RS02725 1818bccd90acf338e946db75e09a498d 176 PANTHER PTHR34406 1 176 9.7E-57 T 21-04-2016 SPH21_RS02725 1818bccd90acf338e946db75e09a498d 176 Gene3D G3DSA:2.40.128.110 5 175 4.8E-61 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS02725 1818bccd90acf338e946db75e09a498d 176 SUPERFAMILY SSF101874 5 175 7.59E-56 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS02725 1818bccd90acf338e946db75e09a498d 176 SMART SM00867 4 173 8.6E-65 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS02725 1818bccd90acf338e946db75e09a498d 176 Pfam PF04264 YceI-like domain 5 172 1.2E-45 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS06265 d30e8eaea191a08e9cfff4b6e4e4969e 260 PANTHER PTHR11019:SF126 125 260 7.1E-14 T 21-04-2016 SPH21_RS06265 d30e8eaea191a08e9cfff4b6e4e4969e 260 Gene3D G3DSA:1.10.10.60 158 206 1.9E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06265 d30e8eaea191a08e9cfff4b6e4e4969e 260 SMART SM00342 172 256 4.0E-11 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS06265 d30e8eaea191a08e9cfff4b6e4e4969e 260 Gene3D G3DSA:1.10.10.60 223 257 2.4E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06265 d30e8eaea191a08e9cfff4b6e4e4969e 260 PANTHER PTHR11019 125 260 7.1E-14 T 21-04-2016 SPH21_RS06265 d30e8eaea191a08e9cfff4b6e4e4969e 260 SUPERFAMILY SSF46689 223 258 2.02E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06265 d30e8eaea191a08e9cfff4b6e4e4969e 260 Pfam PF12833 Helix-turn-helix domain 178 257 1.5E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24685 40fd6dbb763aba7db815d51feb741f56 276 SUPERFAMILY SSF52266 2 273 7.69E-79 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS24685 40fd6dbb763aba7db815d51feb741f56 276 PANTHER PTHR31988:SF1 1 243 7.1E-47 T 21-04-2016 SPH21_RS24685 40fd6dbb763aba7db815d51feb741f56 276 PANTHER PTHR31988 1 243 7.1E-47 T 21-04-2016 SPH21_RS24685 40fd6dbb763aba7db815d51feb741f56 276 Pfam PF03629 Carbohydrate esterase, sialic acid-specific acetylesterase 108 206 3.8E-8 T 21-04-2016 IPR005181 Sialate O-acetylesterase domain SPH21_RS04995 d5d5b2786a48737a4e275afb69481720 171 PANTHER PTHR13256:SF20 8 147 1.7E-24 T 21-04-2016 SPH21_RS04995 d5d5b2786a48737a4e275afb69481720 171 PANTHER PTHR13256 8 147 1.7E-24 T 21-04-2016 SPH21_RS04995 d5d5b2786a48737a4e275afb69481720 171 Gene3D G3DSA:3.40.630.30 5 147 5.7E-30 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS04995 d5d5b2786a48737a4e275afb69481720 171 Pfam PF13302 Acetyltransferase (GNAT) domain 12 145 1.1E-18 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS04995 d5d5b2786a48737a4e275afb69481720 171 SUPERFAMILY SSF55729 5 150 3.69E-23 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 SMART SM01217 709 778 1.7E-29 T 21-04-2016 IPR026891 Fibronectin type III-like domain SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PANTHER PTHR30620 1 64 0.0 T 21-04-2016 IPR026892 Glycoside hydrolase family 3 GO:0004553 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PANTHER PTHR30620 102 522 0.0 T 21-04-2016 IPR026892 Glycoside hydrolase family 3 GO:0004553 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PANTHER PTHR30620 548 792 0.0 T 21-04-2016 IPR026892 Glycoside hydrolase family 3 GO:0004553 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 SUPERFAMILY SSF52279 424 520 4.71E-57 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 SUPERFAMILY SSF52279 547 675 4.71E-57 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PANTHER PTHR30620:SF37 1 64 0.0 T 21-04-2016 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PANTHER PTHR30620:SF37 102 522 0.0 T 21-04-2016 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PANTHER PTHR30620:SF37 548 792 0.0 T 21-04-2016 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 424 672 8.4E-62 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 Pfam PF14310 Fibronectin type III-like domain 709 778 6.8E-21 T 21-04-2016 IPR026891 Fibronectin type III-like domain SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 Gene3D G3DSA:3.20.20.300 29 403 2.4E-121 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 306 323 - T 21-04-2016 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 49 384 1.4E-72 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PRINTS PR00133 Glycosyl hydrolase family 3 signature 236 252 8.4E-22 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PRINTS PR00133 Glycosyl hydrolase family 3 signature 199 215 8.4E-22 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PRINTS PR00133 Glycosyl hydrolase family 3 signature 153 172 8.4E-22 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PRINTS PR00133 Glycosyl hydrolase family 3 signature 130 146 8.4E-22 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 PRINTS PR00133 Glycosyl hydrolase family 3 signature 306 324 8.4E-22 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 Gene3D G3DSA:3.40.50.1700 410 675 1.7E-81 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS15600 32ba197bf068c4db6b14934df8548496 795 SUPERFAMILY SSF51445 28 423 1.47E-112 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS04510 5d08258a471a27de51f51f709f6f225e 206 PANTHER PTHR10108:SF860 9 190 2.9E-65 T 21-04-2016 SPH21_RS04510 5d08258a471a27de51f51f709f6f225e 206 PANTHER PTHR10108 9 190 2.9E-65 T 21-04-2016 SPH21_RS04510 5d08258a471a27de51f51f709f6f225e 206 SUPERFAMILY SSF53335 7 198 2.94E-36 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS04510 5d08258a471a27de51f51f709f6f225e 206 Pfam PF08241 Methyltransferase domain 48 140 5.5E-18 T 21-04-2016 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SPH21_RS04510 5d08258a471a27de51f51f709f6f225e 206 Gene3D G3DSA:3.40.50.150 26 197 7.6E-28 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS20190 76daaebc838a84741dadcb09db62bbf0 175 Gene3D G3DSA:1.20.120.450 11 158 2.6E-5 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 Gene3D G3DSA:3.40.630.10 17 86 9.7E-72 T 21-04-2016 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 Gene3D G3DSA:3.40.630.10 181 366 9.7E-72 T 21-04-2016 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 PANTHER PTHR32481 15 372 2.1E-111 T 21-04-2016 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 SUPERFAMILY SSF53187 187 360 8.2E-59 T 21-04-2016 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 SUPERFAMILY SSF53187 19 97 8.2E-59 T 21-04-2016 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 PIRSF PIRSF001123 17 370 1.0E-85 T 21-04-2016 IPR008007 Peptidase M42 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 Gene3D G3DSA:2.40.30.40 87 174 3.5E-23 T 21-04-2016 IPR023367 Peptidase M42, domain 2 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 PANTHER PTHR32481:SF10 15 372 2.1E-111 T 21-04-2016 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 SUPERFAMILY SSF101821 86 192 5.19E-27 T 21-04-2016 SPH21_RS25840 402f7c7a268e302b13d9ddc5c11b5956 372 Pfam PF05343 M42 glutamyl aminopeptidase 62 353 1.0E-73 T 21-04-2016 IPR008007 Peptidase M42 SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 Pfam PF00072 Response regulator receiver domain 9 117 1.9E-13 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 Gene3D G3DSA:2.40.50.40 148 216 3.6E-18 T 21-04-2016 SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 PANTHER PTHR26402 6 117 5.9E-20 T 21-04-2016 SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 Pfam PF04397 LytTr DNA-binding domain 158 241 3.3E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 Gene3D G3DSA:3.40.50.2300 5 125 9.2E-21 T 21-04-2016 SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 SMART SM00448 6 117 1.5E-15 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 SUPERFAMILY SSF52172 4 135 3.27E-23 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS03245 ba5e68d43673835b0a7bba49dc2466f9 256 SMART SM00850 156 251 3.9E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS18950 e914b74b8cbde92f9200d4b74b1cc49a 68 Pfam PF13619 KTSC domain 3 59 1.8E-21 T 21-04-2016 IPR025309 KTSC domain SPH21_RS03440 0054a34ec405b9dda30f982ae87a3234 1018 Pfam PF14028 Lantibiotic biosynthesis dehydratase C-term 760 942 2.2E-34 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS03440 0054a34ec405b9dda30f982ae87a3234 1018 Pfam PF04738 Lantibiotic dehydratase, C terminus 41 694 1.0E-157 T 21-04-2016 IPR006827 Lantibiotic dehydratase, C-terminal SPH21_RS03440 0054a34ec405b9dda30f982ae87a3234 1018 TIGRFAM TIGR03891 thiopep_ocin: thiopeptide-type bacteriocin biosynthesis domain 760 1002 5.0E-46 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS18570 38c5e29df6d016523ec2b76b25897430 166 Gene3D G3DSA:1.20.1260.10 7 165 1.7E-52 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS18570 38c5e29df6d016523ec2b76b25897430 166 Pfam PF05974 Domain of unknown function (DUF892) 15 165 2.8E-45 T 21-04-2016 IPR010287 Domain of unknown function DUF892 SPH21_RS18570 38c5e29df6d016523ec2b76b25897430 166 PANTHER PTHR30565 13 166 1.5E-36 T 21-04-2016 SPH21_RS18570 38c5e29df6d016523ec2b76b25897430 166 SUPERFAMILY SSF47240 10 163 5.48E-39 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS18570 38c5e29df6d016523ec2b76b25897430 166 PANTHER PTHR30565:SF2 13 166 1.5E-36 T 21-04-2016 SPH21_RS20215 eea7174abf9ba10791698565d74f7811 573 SUPERFAMILY SSF53187 30 310 1.36E-36 T 21-04-2016 SPH21_RS20215 eea7174abf9ba10791698565d74f7811 573 PANTHER PTHR11705:SF82 32 350 1.2E-31 T 21-04-2016 SPH21_RS20215 eea7174abf9ba10791698565d74f7811 573 Gene3D G3DSA:3.40.630.10 31 310 2.5E-26 T 21-04-2016 SPH21_RS20215 eea7174abf9ba10791698565d74f7811 573 PANTHER PTHR11705 32 350 1.2E-31 T 21-04-2016 SPH21_RS20215 eea7174abf9ba10791698565d74f7811 573 Pfam PF00246 Zinc carboxypeptidase 40 187 4.4E-9 T 21-04-2016 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SPH21_RS12210 1fe916d4f7caede7d1b38c4e7bbda7d1 189 Gene3D G3DSA:1.25.10.10 31 185 5.3E-5 T 21-04-2016 IPR011989 Armadillo-like helical SPH21_RS12210 1fe916d4f7caede7d1b38c4e7bbda7d1 189 SUPERFAMILY SSF48371 31 185 4.43E-8 T 21-04-2016 IPR016024 Armadillo-type fold GO:0005488 SPH21_RS21535 14d2c4b1d2920f6fb8f035be557e1b09 148 Pfam PF09917 Uncharacterized protein conserved in bacteria (DUF2147) 29 146 3.8E-29 T 21-04-2016 IPR019223 Domain of unknown function DUF2147 SPH21_RS21535 14d2c4b1d2920f6fb8f035be557e1b09 148 PANTHER PTHR36919 1 147 7.6E-18 T 21-04-2016 SPH21_RS20585 0ff455b4659754919f2ab97791fa2e7a 261 Gene3D G3DSA:2.40.160.20 48 209 2.6E-5 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS20585 0ff455b4659754919f2ab97791fa2e7a 261 SUPERFAMILY SSF103515 58 214 2.22E-5 T 21-04-2016 IPR005546 Autotransporter beta-domain SPH21_RS20585 0ff455b4659754919f2ab97791fa2e7a 261 Pfam PF13568 Outer membrane protein beta-barrel domain 51 222 4.5E-27 T 21-04-2016 IPR025665 Outer membrane protein beta-barrel domain SPH21_RS18460 8cc5dcd193443b469aa5db4b56106b9c 446 Pfam PF13520 Amino acid permease 19 428 8.4E-52 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS18460 8cc5dcd193443b469aa5db4b56106b9c 446 PIRSF PIRSF006060 4 446 1.0E-73 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS18460 8cc5dcd193443b469aa5db4b56106b9c 446 PANTHER PTHR11785 4 446 2.7E-93 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS18460 8cc5dcd193443b469aa5db4b56106b9c 446 PANTHER PTHR11785:SF261 4 446 2.7E-93 T 21-04-2016 SPH21_RS15235 7efe8aaac70b9dba07e5f075bee6476b 245 PANTHER PTHR21294 1 245 1.3E-62 T 21-04-2016 IPR012255 Electron transfer flavoprotein, beta subunit GO:0009055 SPH21_RS15235 7efe8aaac70b9dba07e5f075bee6476b 245 Gene3D G3DSA:3.40.50.620 1 243 8.5E-68 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15235 7efe8aaac70b9dba07e5f075bee6476b 245 SUPERFAMILY SSF52402 1 239 4.05E-60 T 21-04-2016 SPH21_RS15235 7efe8aaac70b9dba07e5f075bee6476b 245 PANTHER PTHR21294:SF0 1 245 1.3E-62 T 21-04-2016 SPH21_RS15235 7efe8aaac70b9dba07e5f075bee6476b 245 Pfam PF01012 Electron transfer flavoprotein domain 28 203 3.4E-33 T 21-04-2016 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: REACT_6305 SPH21_RS15235 7efe8aaac70b9dba07e5f075bee6476b 245 SMART SM00893 23 209 4.0E-32 T 21-04-2016 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: REACT_6305 SPH21_RS15235 7efe8aaac70b9dba07e5f075bee6476b 245 PIRSF PIRSF000090 1 245 5.0E-56 T 21-04-2016 IPR012255 Electron transfer flavoprotein, beta subunit GO:0009055 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Gene3D G3DSA:2.170.130.10 198 308 2.2E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 PANTHER PTHR11532:SF57 8 463 2.6E-217 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 PANTHER PTHR11532:SF57 507 846 2.6E-217 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 PANTHER PTHR11532 507 846 2.6E-217 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Pfam PF13715 CarboxypepD_reg-like domain 113 194 4.1E-19 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 PANTHER PTHR11532 864 1069 2.6E-217 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 SUPERFAMILY SSF56935 984 1044 1.53E-81 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 SUPERFAMILY SSF56935 904 952 1.53E-81 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 SUPERFAMILY SSF56935 192 336 1.53E-81 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 SUPERFAMILY SSF56935 378 448 1.53E-81 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 SUPERFAMILY SSF56935 480 838 1.53E-81 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Gene3D G3DSA:2.60.40.1120 113 197 2.5E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Pfam PF07715 TonB-dependent Receptor Plug Domain 203 307 3.5E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 113 1071 9.1E-223 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 PANTHER PTHR11532:SF57 864 1069 2.6E-217 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Gene3D G3DSA:2.40.170.20 976 1071 8.1E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Gene3D G3DSA:2.40.170.20 309 328 8.1E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Gene3D G3DSA:2.40.170.20 378 465 8.1E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Gene3D G3DSA:2.40.170.20 498 862 8.1E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 Gene3D G3DSA:2.40.170.20 917 942 8.1E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 283 313 5.2E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 PANTHER PTHR11532 8 463 2.6E-217 T 21-04-2016 SPH21_RS23210 ffff578e9173f72c5fee799c9f081ab3 1071 SUPERFAMILY SSF49464 112 192 4.19E-19 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS17195 9a7a82b99e5cc0e9cc84acc25dad49f5 349 PANTHER PTHR30040 3 345 1.0E-97 T 21-04-2016 SPH21_RS17195 9a7a82b99e5cc0e9cc84acc25dad49f5 349 Pfam PF02424 ApbE family 44 319 4.2E-73 T 21-04-2016 IPR024932 Flavin transferase ApbE GO:0017013 SPH21_RS17195 9a7a82b99e5cc0e9cc84acc25dad49f5 349 SUPERFAMILY SSF143631 36 341 2.62E-80 T 21-04-2016 IPR003374 ApbE-like domain SPH21_RS17195 9a7a82b99e5cc0e9cc84acc25dad49f5 349 PIRSF PIRSF006268 6 341 1.3E-77 T 21-04-2016 IPR024932 Flavin transferase ApbE GO:0017013 SPH21_RS17195 9a7a82b99e5cc0e9cc84acc25dad49f5 349 PANTHER PTHR30040:SF3 3 345 1.0E-97 T 21-04-2016 SPH21_RS25515 edf2e71c96b9b47ce64c54371cc08638 60 Pfam PF00471 Ribosomal protein L33 8 60 2.3E-20 T 21-04-2016 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS25515 edf2e71c96b9b47ce64c54371cc08638 60 PANTHER PTHR15238:SF3 1 60 5.4E-24 T 21-04-2016 SPH21_RS25515 edf2e71c96b9b47ce64c54371cc08638 60 Hamap MF_00294 50S ribosomal protein L33 [rpmG]. 2 60 15.181 T 21-04-2016 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS25515 edf2e71c96b9b47ce64c54371cc08638 60 TIGRFAM TIGR01023 rpmG_bact: ribosomal protein bL33 1 60 2.2E-19 T 21-04-2016 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS25515 edf2e71c96b9b47ce64c54371cc08638 60 SUPERFAMILY SSF57829 3 60 3.42E-16 T 21-04-2016 IPR011332 Zinc-binding ribosomal protein GO:0006412 SPH21_RS25515 edf2e71c96b9b47ce64c54371cc08638 60 PANTHER PTHR15238 1 60 5.4E-24 T 21-04-2016 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 SUPERFAMILY SSF88946 7 102 3.85E-22 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 Gene3D G3DSA:1.10.10.10 114 176 9.8E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 PANTHER PTHR30173 9 175 2.7E-39 T 21-04-2016 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 SUPERFAMILY SSF88659 116 175 6.17E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 20 174 2.3E-29 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 Gene3D G3DSA:1.10.1740.10 6 99 4.0E-24 T 21-04-2016 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 Pfam PF08281 Sigma-70, region 4 118 170 1.3E-14 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 PANTHER PTHR30173:SF20 9 175 2.7E-39 T 21-04-2016 SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 19 174 1.0E-37 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS09405 b3f2225949fa84c60c2ee06023256ccc 181 Pfam PF04542 Sigma-70 region 2 24 91 9.7E-13 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS07240 b28aed7ecfbdce82d793d34492b246fb 232 PANTHER PTHR14969 42 211 1.2E-20 T 21-04-2016 SPH21_RS07240 b28aed7ecfbdce82d793d34492b246fb 232 Gene3D G3DSA:1.20.144.10 42 214 2.4E-35 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS07240 b28aed7ecfbdce82d793d34492b246fb 232 Pfam PF01569 PAP2 superfamily 89 207 2.2E-23 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS07240 b28aed7ecfbdce82d793d34492b246fb 232 SMART SM00014 87 202 3.4E-16 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS07240 b28aed7ecfbdce82d793d34492b246fb 232 SUPERFAMILY SSF48317 13 213 2.22E-37 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS02190 587a9d67ca9499ecfd471fbd6dec8507 1082 PANTHER PTHR22925:SF40 354 554 2.7E-40 T 21-04-2016 SPH21_RS02190 587a9d67ca9499ecfd471fbd6dec8507 1082 Gene3D G3DSA:2.60.120.260 928 1041 6.3E-16 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02190 587a9d67ca9499ecfd471fbd6dec8507 1082 Pfam PF17132 alpha-L-rhamnosidase 41 879 5.8E-269 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS02190 587a9d67ca9499ecfd471fbd6dec8507 1082 PANTHER PTHR22925 354 554 2.7E-40 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02190 587a9d67ca9499ecfd471fbd6dec8507 1082 SUPERFAMILY SSF49785 928 1080 1.7E-19 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS13895 198231aafe45d62ed6d87a7b780c473c 175 SUPERFAMILY SSF55961 3 171 2.3E-39 T 21-04-2016 SPH21_RS13895 198231aafe45d62ed6d87a7b780c473c 175 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 22 150 1.2E-16 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS13895 198231aafe45d62ed6d87a7b780c473c 175 Gene3D G3DSA:3.30.530.20 12 174 5.8E-43 T 21-04-2016 IPR023393 START-like domain SPH21_RS24790 347db0ba7fcb9bd08075443d9c0f7fb9 370 PANTHER PTHR23028:SF54 9 369 3.2E-106 T 21-04-2016 SPH21_RS24790 347db0ba7fcb9bd08075443d9c0f7fb9 370 Pfam PF01757 Acyltransferase family 14 353 1.6E-29 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS24790 347db0ba7fcb9bd08075443d9c0f7fb9 370 PANTHER PTHR23028 9 369 3.2E-106 T 21-04-2016 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 Gene3D G3DSA:3.40.50.1360 73 211 3.2E-9 T 21-04-2016 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 PANTHER PTHR30363 1 242 2.4E-56 T 21-04-2016 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 PANTHER PTHR30363:SF1 1 242 2.4E-56 T 21-04-2016 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 SUPERFAMILY SSF46785 4 62 2.16E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 Gene3D G3DSA:1.10.10.10 1 49 5.4E-6 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 SUPERFAMILY SSF100950 73 230 4.19E-25 T 21-04-2016 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 Pfam PF08220 DeoR-like helix-turn-helix domain 6 59 1.3E-13 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 21-04-2016 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 SMART SM00420 6 58 4.3E-13 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 Pfam PF00455 DeoR C terminal sensor domain 73 229 2.0E-39 T 21-04-2016 IPR014036 DeoR C-terminal sensor domain SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 SMART SM01134 70 231 4.0E-49 T 21-04-2016 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 3.3E-8 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS16280 78d1fe73a2b3bdb9ea141af3d67f8940 247 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 3.3E-8 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS11425 b1191d887cdd3ee393de56a6b5e6b48e 445 Gene3D G3DSA:3.40.50.1820 96 392 2.3E-32 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS11425 b1191d887cdd3ee393de56a6b5e6b48e 445 Pfam PF05448 Acetyl xylan esterase (AXE1) 241 292 3.4E-7 T 21-04-2016 IPR008391 Acetyl xylan esterase SPH21_RS11425 b1191d887cdd3ee393de56a6b5e6b48e 445 SUPERFAMILY SSF53474 104 300 6.39E-22 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS08925 b59ca29f61da73f6f19302d254abe088 363 Pfam PF14307 Glycosyltransferase WbsX 149 344 1.8E-11 T 21-04-2016 IPR032719 Glycosyltransferase WbsX SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 Pfam PF01259 SAICAR synthetase 17 259 1.4E-80 T 21-04-2016 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074 SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 SUPERFAMILY SSF56104 7 291 9.16E-88 T 21-04-2016 SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 PANTHER PTHR11609 6 314 1.6E-90 T 21-04-2016 SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 ProSitePatterns PS01058 SAICAR synthetase signature 2. 195 203 - T 21-04-2016 IPR018236 SAICAR synthetase, conserved site GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074 SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 Gene3D G3DSA:3.30.470.20 105 233 9.7E-47 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 Hamap MF_00137 Phosphoribosylaminoimidazole-succinocarboxamide synthase [purC]. 14 288 21.818 T 21-04-2016 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|UniPathway: UPA00074 SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 PANTHER PTHR11609:SF9 6 314 1.6E-90 T 21-04-2016 SPH21_RS12545 b3795179302db01270817ed5e69d5943 318 Gene3D G3DSA:3.30.200.20 7 104 2.8E-36 T 21-04-2016 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 Pfam PF00732 GMC oxidoreductase 186 315 4.8E-8 T 21-04-2016 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 PANTHER PTHR11552:SF139 64 202 1.9E-48 T 21-04-2016 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 PANTHER PTHR11552:SF139 220 566 1.9E-48 T 21-04-2016 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 PANTHER PTHR11552:SF139 9 47 1.9E-48 T 21-04-2016 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 Pfam PF05199 GMC oxidoreductase 430 554 4.1E-18 T 21-04-2016 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 Gene3D G3DSA:3.50.50.60 455 561 1.4E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 Gene3D G3DSA:3.50.50.60 6 158 1.4E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 Gene3D G3DSA:3.50.50.60 232 340 1.4E-67 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 SUPERFAMILY SSF51905 502 563 8.94E-57 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 SUPERFAMILY SSF51905 98 342 8.94E-57 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 SUPERFAMILY SSF51905 5 71 8.94E-57 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 SUPERFAMILY SSF54373 354 502 6.28E-30 T 21-04-2016 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 PANTHER PTHR11552 64 202 1.9E-48 T 21-04-2016 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 PANTHER PTHR11552 220 566 1.9E-48 T 21-04-2016 SPH21_RS14160 428c36cf979c6c7d7e41b406915ed764 567 PANTHER PTHR11552 9 47 1.9E-48 T 21-04-2016 SPH21_RS13240 6728ca57e69e30bc46580357236ef17a 186 SUPERFAMILY SSF52833 1 179 2.18E-29 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS13240 6728ca57e69e30bc46580357236ef17a 186 Pfam PF00578 AhpC/TSA family 41 161 6.6E-22 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS13240 6728ca57e69e30bc46580357236ef17a 186 Gene3D G3DSA:3.40.30.10 1 184 6.8E-38 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS13240 6728ca57e69e30bc46580357236ef17a 186 PANTHER PTHR10681 38 161 4.8E-25 T 21-04-2016 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 ProSitePatterns PS00927 Trehalase signature 1. 120 133 - T 21-04-2016 IPR018232 Glycoside hydrolase, family 37, conserved site GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PANTHER PTHR23403:SF13 9 498 1.1E-198 T 21-04-2016 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PANTHER PTHR23403 9 498 1.1E-198 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 SUPERFAMILY SSF48208 7 497 2.11E-150 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PRINTS PR00744 Glycosyl hydrolase family 37 signature 162 180 5.1E-43 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PRINTS PR00744 Glycosyl hydrolase family 37 signature 339 355 5.1E-43 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PRINTS PR00744 Glycosyl hydrolase family 37 signature 480 493 5.1E-43 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PRINTS PR00744 Glycosyl hydrolase family 37 signature 264 281 5.1E-43 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PRINTS PR00744 Glycosyl hydrolase family 37 signature 231 248 5.1E-43 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PRINTS PR00744 Glycosyl hydrolase family 37 signature 403 419 5.1E-43 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 PRINTS PR00744 Glycosyl hydrolase family 37 signature 296 313 5.1E-43 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 Pfam PF01204 Trehalase 26 497 2.7E-143 T 21-04-2016 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS06155 b33469c963677265f4ae41c4a909aaca 499 ProSitePatterns PS00928 Trehalase signature 2. 410 419 - T 21-04-2016 IPR018232 Glycoside hydrolase, family 37, conserved site GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28 SPH21_RS21395 c3a1a8cc55966301c0e9ef33d9583784 200 SUPERFAMILY SSF52218 4 190 1.82E-47 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS21395 c3a1a8cc55966301c0e9ef33d9583784 200 PANTHER PTHR10204:SF40 4 185 7.8E-38 T 21-04-2016 SPH21_RS21395 c3a1a8cc55966301c0e9ef33d9583784 200 Pfam PF02525 Flavodoxin-like fold 4 183 2.6E-35 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS21395 c3a1a8cc55966301c0e9ef33d9583784 200 PANTHER PTHR10204 4 185 7.8E-38 T 21-04-2016 SPH21_RS21395 c3a1a8cc55966301c0e9ef33d9583784 200 Gene3D G3DSA:3.40.50.360 4 191 1.4E-41 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS12490 785bf652b7581df4bd9524748dcbfac0 405 Pfam PF09411 Lipid A 3-O-deacylase (PagL) 154 228 3.1E-6 T 21-04-2016 IPR018550 Lipid A 3-O-deacylase-related SPH21_RS12490 785bf652b7581df4bd9524748dcbfac0 405 Gene3D G3DSA:2.40.160.20 102 232 5.1E-8 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS15330 ff1dd80f66b9dada8c05fd93d0b0751a 274 Gene3D G3DSA:3.40.50.1110 20 273 9.5E-67 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS15330 ff1dd80f66b9dada8c05fd93d0b0751a 274 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 26 262 6.4E-20 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS15330 ff1dd80f66b9dada8c05fd93d0b0751a 274 SUPERFAMILY SSF52266 20 204 5.66E-37 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS15330 ff1dd80f66b9dada8c05fd93d0b0751a 274 SUPERFAMILY SSF52266 239 271 5.66E-37 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS23565 cd185d7d4aecee114f24733b0f09a69b 352 PANTHER PTHR10361 13 352 1.2E-151 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS23565 cd185d7d4aecee114f24733b0f09a69b 352 Pfam PF01758 Sodium Bile acid symporter family 60 256 3.4E-67 T 21-04-2016 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SPH21_RS23565 cd185d7d4aecee114f24733b0f09a69b 352 PANTHER PTHR10361:SF31 13 352 1.2E-151 T 21-04-2016 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SPH21_RS23565 cd185d7d4aecee114f24733b0f09a69b 352 TIGRFAM TIGR00832 acr3: arsenical-resistance protein 15 344 8.7E-137 T 21-04-2016 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SPH21_RS23565 cd185d7d4aecee114f24733b0f09a69b 352 PIRSF PIRSF005508 2 352 4.2E-135 T 21-04-2016 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SPH21_RS18440 88fcd1e1a98c1329019a4653db0b972a 281 Pfam PF00005 ABC transporter 17 168 3.9E-25 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS18440 88fcd1e1a98c1329019a4653db0b972a 281 SMART SM00382 26 216 1.2E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS18440 88fcd1e1a98c1329019a4653db0b972a 281 SUPERFAMILY SSF52540 3 234 1.86E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18440 88fcd1e1a98c1329019a4653db0b972a 281 Gene3D G3DSA:3.40.50.300 5 233 1.8E-55 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18440 88fcd1e1a98c1329019a4653db0b972a 281 PANTHER PTHR24220:SF558 3 255 3.7E-75 T 21-04-2016 SPH21_RS18440 88fcd1e1a98c1329019a4653db0b972a 281 PANTHER PTHR24220 3 255 3.7E-75 T 21-04-2016 SPH21_RS05900 881de02d2ddeb0d7c3a7dd1df7f39cea 804 PANTHER PTHR30572 409 804 2.5E-72 T 21-04-2016 SPH21_RS05900 881de02d2ddeb0d7c3a7dd1df7f39cea 804 PANTHER PTHR30572 294 363 2.5E-72 T 21-04-2016 SPH21_RS05900 881de02d2ddeb0d7c3a7dd1df7f39cea 804 PANTHER PTHR30572:SF4 409 804 2.5E-72 T 21-04-2016 SPH21_RS05900 881de02d2ddeb0d7c3a7dd1df7f39cea 804 PANTHER PTHR30572:SF4 294 363 2.5E-72 T 21-04-2016 SPH21_RS05900 881de02d2ddeb0d7c3a7dd1df7f39cea 804 Pfam PF12704 MacB-like periplasmic core domain 20 211 6.5E-16 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05900 881de02d2ddeb0d7c3a7dd1df7f39cea 804 Pfam PF02687 FtsX-like permease family 297 410 1.9E-12 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05900 881de02d2ddeb0d7c3a7dd1df7f39cea 804 Pfam PF02687 FtsX-like permease family 684 792 8.2E-13 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS06260 25ad586736824998e76f1a6c52b67447 208 SUPERFAMILY SSF51735 1 207 7.78E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06260 25ad586736824998e76f1a6c52b67447 208 Pfam PF13460 NAD(P)H-binding 7 195 1.5E-48 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06260 25ad586736824998e76f1a6c52b67447 208 Gene3D G3DSA:3.40.50.720 1 207 1.0E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06260 25ad586736824998e76f1a6c52b67447 208 PANTHER PTHR15020 1 206 7.0E-47 T 21-04-2016 SPH21_RS14665 8c15f8fb98edc5d9217b514bd28e8947 366 Pfam PF04773 FecR protein 159 248 8.0E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS14665 8c15f8fb98edc5d9217b514bd28e8947 366 Pfam PF16344 Domain of unknown function (DUF4974) 263 354 9.3E-14 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS14665 8c15f8fb98edc5d9217b514bd28e8947 366 PANTHER PTHR30273:SF2 46 107 2.0E-59 T 21-04-2016 SPH21_RS14665 8c15f8fb98edc5d9217b514bd28e8947 366 PANTHER PTHR30273:SF2 156 366 2.0E-59 T 21-04-2016 SPH21_RS14665 8c15f8fb98edc5d9217b514bd28e8947 366 PANTHER PTHR30273 46 107 2.0E-59 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS14665 8c15f8fb98edc5d9217b514bd28e8947 366 PANTHER PTHR30273 156 366 2.0E-59 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS19925 fef1ba2b4d776cf5c0f1bb290f43aaad 435 TIGRFAM TIGR01981 sufD: FeS assembly protein SufD 148 422 2.8E-71 T 21-04-2016 IPR011542 SUF system FeS cluster assembly, SufD GO:0016226 SPH21_RS19925 fef1ba2b4d776cf5c0f1bb290f43aaad 435 PANTHER PTHR30508:SF0 33 435 4.8E-100 T 21-04-2016 SPH21_RS19925 fef1ba2b4d776cf5c0f1bb290f43aaad 435 PANTHER PTHR30508 33 435 4.8E-100 T 21-04-2016 SPH21_RS19925 fef1ba2b4d776cf5c0f1bb290f43aaad 435 Pfam PF01458 Uncharacterized protein family (UPF0051) 183 407 1.3E-67 T 21-04-2016 IPR000825 SUF system FeS cluster assembly, SufBD GO:0016226 SPH21_RS19925 fef1ba2b4d776cf5c0f1bb290f43aaad 435 SUPERFAMILY SSF101960 17 432 2.62E-98 T 21-04-2016 SPH21_RS20235 546ffacb437375868fa250f674916203 211 Pfam PF13568 Outer membrane protein beta-barrel domain 24 190 1.0E-15 T 21-04-2016 IPR025665 Outer membrane protein beta-barrel domain SPH21_RS00760 60ed537993fda19530d48ca7a79ceb31 127 SMART SM00530 6 61 9.4E-6 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS00760 60ed537993fda19530d48ca7a79ceb31 127 Pfam PF01381 Helix-turn-helix 7 61 2.0E-6 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS00760 60ed537993fda19530d48ca7a79ceb31 127 Gene3D G3DSA:1.10.260.40 2 100 3.6E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS00760 60ed537993fda19530d48ca7a79ceb31 127 SUPERFAMILY SSF47413 1 66 2.82E-11 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS17885 72049cd6a80679158911c18e7a5a8561 187 PANTHER PTHR30574:SF1 106 182 7.8E-26 T 21-04-2016 SPH21_RS17885 72049cd6a80679158911c18e7a5a8561 187 PANTHER PTHR30574:SF1 1 77 7.8E-26 T 21-04-2016 SPH21_RS17885 72049cd6a80679158911c18e7a5a8561 187 PANTHER PTHR30574 106 182 7.8E-26 T 21-04-2016 SPH21_RS17885 72049cd6a80679158911c18e7a5a8561 187 PANTHER PTHR30574 1 77 7.8E-26 T 21-04-2016 SPH21_RS17885 72049cd6a80679158911c18e7a5a8561 187 Pfam PF04143 Sulphur transport 121 175 1.3E-11 T 21-04-2016 IPR007272 Sulphur transport domain SPH21_RS14925 346a5b0bf51deb5e322ad885bf06350d 240 SUPERFAMILY SSF102588 3 237 4.32E-51 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS14925 346a5b0bf51deb5e322ad885bf06350d 240 TIGRFAM TIGR04001 thiol_BshB1: bacillithiol biosynthesis deacetylase BshB1 2 233 2.1E-87 T 21-04-2016 IPR023842 Bacillithiol biosynthesis deacetylase, BshB1 GO:0019213|GO:0071793 SPH21_RS14925 346a5b0bf51deb5e322ad885bf06350d 240 PANTHER PTHR12993 3 206 1.0E-36 T 21-04-2016 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related SPH21_RS14925 346a5b0bf51deb5e322ad885bf06350d 240 Gene3D G3DSA:3.40.50.10320 3 235 1.0E-55 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS14925 346a5b0bf51deb5e322ad885bf06350d 240 Pfam PF02585 GlcNAc-PI de-N-acetylase 6 122 9.1E-18 T 21-04-2016 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related SPH21_RS00710 b58332b5ee598e9d641406101b3411e9 158 SUPERFAMILY SSF54427 42 157 6.84E-12 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS00710 b58332b5ee598e9d641406101b3411e9 158 Gene3D G3DSA:3.10.450.50 42 157 3.2E-17 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS19005 ff262e6bdf61a894e8302620145c3f48 588 Pfam PF16861 Carbamoyltransferase C-terminus 402 570 9.2E-73 T 21-04-2016 IPR031730 Carbamoyltransferase, C-terminal SPH21_RS19005 ff262e6bdf61a894e8302620145c3f48 588 SUPERFAMILY SSF53067 1 87 6.48E-19 T 21-04-2016 SPH21_RS19005 ff262e6bdf61a894e8302620145c3f48 588 SUPERFAMILY SSF53067 148 351 6.48E-19 T 21-04-2016 SPH21_RS19005 ff262e6bdf61a894e8302620145c3f48 588 PANTHER PTHR34847 1 585 1.0E-122 T 21-04-2016 SPH21_RS19005 ff262e6bdf61a894e8302620145c3f48 588 Pfam PF02543 Carbamoyltransferase N-terminus 4 350 3.1E-71 T 21-04-2016 IPR003696 Carbamoyltransferase GO:0003824|GO:0009058 SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 Pfam PF00072 Response regulator receiver domain 3 111 4.0E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 PANTHER PTHR26402:SF578 1 223 7.7E-71 T 21-04-2016 SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 222 2.9E-23 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 SMART SM00448 1 112 5.1E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 PANTHER PTHR26402 1 223 7.7E-71 T 21-04-2016 SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 Gene3D G3DSA:1.10.10.10 124 223 1.1E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 SUPERFAMILY SSF52172 1 172 1.12E-32 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 SMART SM00862 145 222 2.5E-24 T 21-04-2016 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SPH21_RS02525 13f41db5f9d0ca271c7ed9d79d1f8b9f 224 Gene3D G3DSA:3.40.50.2300 1 123 9.2E-31 T 21-04-2016 SPH21_RS06840 f79961079aedb9ad272fbc8694b6c4ee 141 Pfam PF14534 Domain of unknown function (DUF4440) 27 135 1.5E-6 T 21-04-2016 IPR027843 Domain of unknown function DUF4440 SPH21_RS06840 f79961079aedb9ad272fbc8694b6c4ee 141 SUPERFAMILY SSF54427 24 141 2.03E-27 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS06840 f79961079aedb9ad272fbc8694b6c4ee 141 Gene3D G3DSA:3.10.450.50 22 141 7.5E-45 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 19 175 6.8E-27 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 Gene3D G3DSA:1.10.1740.10 2 113 5.2E-21 T 21-04-2016 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 SUPERFAMILY SSF88946 6 100 9.42E-20 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 SUPERFAMILY SSF88659 110 175 1.31E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 Pfam PF04542 Sigma-70 region 2 23 84 2.6E-10 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 Pfam PF08281 Sigma-70, region 4 119 170 8.1E-16 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 PANTHER PTHR30173 1 193 4.3E-58 T 21-04-2016 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 PANTHER PTHR30173:SF20 1 193 4.3E-58 T 21-04-2016 SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 Gene3D G3DSA:1.10.10.10 114 178 2.7E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16950 5de0ae0bfdfb6dd60c451c574fda9952 193 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 18 175 5.2E-51 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS21455 de3d1d8b92f78ad6757dd66d94dab00b 385 Pfam PF16344 Domain of unknown function (DUF4974) 276 372 7.3E-20 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS21455 de3d1d8b92f78ad6757dd66d94dab00b 385 PANTHER PTHR30273 173 381 5.4E-66 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21455 de3d1d8b92f78ad6757dd66d94dab00b 385 PANTHER PTHR30273 1 108 5.4E-66 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21455 de3d1d8b92f78ad6757dd66d94dab00b 385 Pfam PF04773 FecR protein 171 265 2.2E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS21455 de3d1d8b92f78ad6757dd66d94dab00b 385 PANTHER PTHR30273:SF2 173 381 5.4E-66 T 21-04-2016 SPH21_RS21455 de3d1d8b92f78ad6757dd66d94dab00b 385 PANTHER PTHR30273:SF2 1 108 5.4E-66 T 21-04-2016 SPH21_RS23325 ade6137868c263c2e82e9f5459f87ec8 126 Gene3D G3DSA:3.40.50.2300 12 121 3.1E-15 T 21-04-2016 SPH21_RS23325 ade6137868c263c2e82e9f5459f87ec8 126 SUPERFAMILY SSF52172 11 113 6.97E-15 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23325 ade6137868c263c2e82e9f5459f87ec8 126 Pfam PF00072 Response regulator receiver domain 24 114 1.7E-8 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03535 c9588e9f15dbbb3fa8ee6892c4ad47a9 566 SUPERFAMILY SSF64182 55 454 1.23E-111 T 21-04-2016 SPH21_RS03535 c9588e9f15dbbb3fa8ee6892c4ad47a9 566 Pfam PF02272 DHHA1 domain 376 438 3.6E-12 T 21-04-2016 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7 SPH21_RS03535 c9588e9f15dbbb3fa8ee6892c4ad47a9 566 TIGRFAM TIGR00644 recJ: single-stranded-DNA-specific exonuclease RecJ 26 560 5.1E-164 T 21-04-2016 IPR004610 Bacterial RecJ exonuclease GO:0006281|GO:0006310|GO:0008409 SPH21_RS03535 c9588e9f15dbbb3fa8ee6892c4ad47a9 566 Pfam PF01368 DHH family 81 216 6.6E-12 T 21-04-2016 IPR001667 DDH domain SPH21_RS03535 c9588e9f15dbbb3fa8ee6892c4ad47a9 566 PANTHER PTHR30255:SF2 1 564 6.5E-209 T 21-04-2016 SPH21_RS03535 c9588e9f15dbbb3fa8ee6892c4ad47a9 566 PANTHER PTHR30255 1 564 6.5E-209 T 21-04-2016 SPH21_RS01585 72b0ce369f5da2862277d370ea980083 884 SUPERFAMILY SSF50998 509 797 5.89E-10 T 21-04-2016 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SPH21_RS01585 72b0ce369f5da2862277d370ea980083 884 Gene3D G3DSA:2.140.10.10 776 808 4.6E-9 T 21-04-2016 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SPH21_RS01585 72b0ce369f5da2862277d370ea980083 884 Gene3D G3DSA:2.140.10.10 512 732 4.6E-9 T 21-04-2016 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 SMART SM00850 146 242 1.2E-21 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 SUPERFAMILY SSF52172 1 127 9.53E-31 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 PANTHER PTHR26402 4 115 3.9E-30 T 21-04-2016 SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 SMART SM00448 4 112 3.0E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 Pfam PF00072 Response regulator receiver domain 6 112 2.7E-22 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 Gene3D G3DSA:2.40.50.40 138 206 1.5E-15 T 21-04-2016 SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 Gene3D G3DSA:3.40.50.2300 2 115 2.6E-29 T 21-04-2016 SPH21_RS10340 ae4056968a9ba49eafa7ac575d7cb1c3 242 Pfam PF04397 LytTr DNA-binding domain 147 240 7.5E-18 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 Pfam PF11818 C-terminal domain of tail specific protease (DUF3340) 583 714 5.3E-32 T 21-04-2016 IPR020992 Tail specific protease, C-terminal SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 Pfam PF03572 Peptidase family S41 372 578 3.1E-45 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 Gene3D G3DSA:3.90.226.10 691 714 4.8E-57 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 Gene3D G3DSA:3.90.226.10 346 582 4.8E-57 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 PANTHER PTHR32060:SF11 546 653 2.5E-206 T 21-04-2016 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 PANTHER PTHR32060:SF11 1 516 2.5E-206 T 21-04-2016 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 PANTHER PTHR32060 546 653 2.5E-206 T 21-04-2016 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 PANTHER PTHR32060 1 516 2.5E-206 T 21-04-2016 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 SUPERFAMILY SSF50156 249 334 5.84E-11 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 Gene3D G3DSA:3.30.750.44 199 261 6.5E-6 T 21-04-2016 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 SUPERFAMILY SSF52096 363 515 8.45E-63 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 SUPERFAMILY SSF52096 195 273 8.45E-63 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 SUPERFAMILY SSF52096 548 588 8.45E-63 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 SMART SM00228 255 332 4.6E-8 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 Pfam PF00595 PDZ domain (Also known as DHR or GLGF) 255 328 5.2E-9 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 TIGRFAM TIGR00225 prc: C-terminal processing peptidase 210 600 2.8E-86 T 21-04-2016 IPR004447 C-terminal-processing peptidase S41A GO:0006508|GO:0008236 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 SMART SM00245 337 580 2.4E-37 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS06700 75aa36c7343ea624a98d11d623aa1b27 728 Gene3D G3DSA:2.30.42.10 262 345 8.8E-16 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 Gene3D G3DSA:3.90.45.10 3 179 1.7E-50 T 21-04-2016 IPR023635 Peptide deformylase SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 4 173 2.8E-32 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 PANTHER PTHR10458 1 188 2.9E-48 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 SUPERFAMILY SSF56420 1 179 7.59E-49 T 21-04-2016 IPR023635 Peptide deformylase SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 Pfam PF01327 Polypeptide deformylase 3 165 6.8E-41 T 21-04-2016 IPR023635 Peptide deformylase SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 Hamap MF_00163 Peptide deformylase [def]. 1 176 23.276 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 PRINTS PR01576 Peptide deformylase signature 134 163 4.7E-23 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 PRINTS PR01576 Peptide deformylase signature 115 133 4.7E-23 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 PRINTS PR01576 Peptide deformylase signature 103 114 4.7E-23 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 PRINTS PR01576 Peptide deformylase signature 32 61 4.7E-23 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS06175 48d4cc2b32e5ba91c720d3a3a25d96e7 189 PIRSF PIRSF004749 1 185 8.9E-42 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05240 be434149d3c6373c0e49d828cd4e26ed 156 Gene3D G3DSA:3.40.140.10 10 152 4.9E-55 T 21-04-2016 SPH21_RS05240 be434149d3c6373c0e49d828cd4e26ed 156 PANTHER PTHR11079:SF72 15 156 5.0E-54 T 21-04-2016 SPH21_RS05240 be434149d3c6373c0e49d828cd4e26ed 156 PANTHER PTHR11079 15 156 5.0E-54 T 21-04-2016 SPH21_RS05240 be434149d3c6373c0e49d828cd4e26ed 156 SUPERFAMILY SSF53927 13 155 6.19E-51 T 21-04-2016 IPR016193 Cytidine deaminase-like GO:0003824 SPH21_RS05240 be434149d3c6373c0e49d828cd4e26ed 156 Pfam PF14437 MafB19-like deaminase 16 152 9.3E-35 T 21-04-2016 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 SPH21_RS05240 be434149d3c6373c0e49d828cd4e26ed 156 Hamap MF_00972 tRNA-specific adenosine deaminase [tadA]. 19 155 43.467 T 21-04-2016 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 Gene3D G3DSA:2.70.98.50 29 115 1.8E-136 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 Gene3D G3DSA:2.70.98.50 292 571 1.8E-136 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 PANTHER PTHR31084:SF4 26 134 1.7E-267 T 21-04-2016 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 PANTHER PTHR31084:SF4 308 915 1.7E-267 T 21-04-2016 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 PANTHER PTHR31084 26 134 1.7E-267 T 21-04-2016 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 PANTHER PTHR31084 308 915 1.7E-267 T 21-04-2016 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 Gene3D G3DSA:2.60.120.260 129 243 7.7E-16 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 SUPERFAMILY SSF48208 438 920 5.67E-93 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 286 435 1.9E-35 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 30 115 2.0E-32 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 146 242 2.5E-7 T 21-04-2016 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS11350 c75b8363d0e197daab8e1ead3f200110 943 SUPERFAMILY SSF49785 135 246 1.42E-16 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS25475 897df685bad301f58e0e8d4f304c25b2 379 SUPERFAMILY SSF53756 1 371 1.2E-37 T 21-04-2016 SPH21_RS25475 897df685bad301f58e0e8d4f304c25b2 379 TIGRFAM TIGR00215 lpxB: lipid-A-disaccharide synthase 5 366 6.6E-87 T 21-04-2016 IPR003835 Glycosyl transferase, family 19 GO:0008915|GO:0009245 KEGG: 00500+2.4.1.18|KEGG: 00540+2.4.1.182|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00359 SPH21_RS25475 897df685bad301f58e0e8d4f304c25b2 379 PANTHER PTHR30372:SF0 1 371 5.0E-107 T 21-04-2016 SPH21_RS25475 897df685bad301f58e0e8d4f304c25b2 379 Gene3D G3DSA:3.40.50.2000 158 344 2.4E-5 T 21-04-2016 SPH21_RS25475 897df685bad301f58e0e8d4f304c25b2 379 Pfam PF02684 Lipid-A-disaccharide synthetase 4 344 3.2E-93 T 21-04-2016 IPR003835 Glycosyl transferase, family 19 GO:0008915|GO:0009245 KEGG: 00500+2.4.1.18|KEGG: 00540+2.4.1.182|MetaCyc: PWY-5067|MetaCyc: PWY-622|UniPathway: UPA00359 SPH21_RS25475 897df685bad301f58e0e8d4f304c25b2 379 PANTHER PTHR30372 1 371 5.0E-107 T 21-04-2016 SPH21_RS06835 19b13cde38a65666f77a529d13e005ee 66 SUPERFAMILY SSF54285 3 65 2.99E-12 T 21-04-2016 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp SPH21_RS06835 19b13cde38a65666f77a529d13e005ee 66 Pfam PF02597 ThiS family 15 66 1.5E-10 T 21-04-2016 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 SPH21_RS06835 19b13cde38a65666f77a529d13e005ee 66 TIGRFAM TIGR01683 thiS: thiamine biosynthesis protein ThiS 5 66 1.8E-16 T 21-04-2016 IPR010035 ThiS, thiamine-biosynthesis SPH21_RS06835 19b13cde38a65666f77a529d13e005ee 66 Gene3D G3DSA:3.10.20.30 1 66 1.6E-17 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 56 71 - T 21-04-2016 IPR031157 Tr-type G domain, conserved site SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 Gene3D G3DSA:3.30.70.870 394 463 5.6E-8 T 21-04-2016 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 SUPERFAMILY SSF50447 260 392 2.36E-27 T 21-04-2016 IPR009000 Translation protein, beta-barrel domain SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PANTHER PTHR23115:SF69 250 486 3.3E-219 T 21-04-2016 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PANTHER PTHR23115:SF69 1 182 3.3E-219 T 21-04-2016 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 Gene3D G3DSA:3.40.50.300 7 281 3.6E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PRINTS PR00315 GTP-binding elongation factor signature 135 144 4.1E-12 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PRINTS PR00315 GTP-binding elongation factor signature 63 71 4.1E-12 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PRINTS PR00315 GTP-binding elongation factor signature 13 26 4.1E-12 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PRINTS PR00315 GTP-binding elongation factor signature 99 110 4.1E-12 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PRINTS PR00315 GTP-binding elongation factor signature 83 93 4.1E-12 T 21-04-2016 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 TIGRFAM TIGR00503 prfC: peptide chain release factor 3 2 527 1.8E-205 T 21-04-2016 IPR004548 Peptide chain release factor 3 GO:0005525|GO:0005737|GO:0006415|GO:0016149 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 Pfam PF16658 Class II release factor RF3, C-terminal domain 386 513 4.1E-42 T 21-04-2016 IPR032090 Peptide chain release factor 3, C-terminal SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 Hamap MF_00072 Peptide chain release factor 3 [prfC]. 2 526 49.298 T 21-04-2016 IPR004548 Peptide chain release factor 3 GO:0005525|GO:0005737|GO:0006415|GO:0016149 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 SUPERFAMILY SSF54980 392 464 1.04E-11 T 21-04-2016 IPR009022 Elongation factor G, III-V domain SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 14 163 1.0E-25 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 Pfam PF00009 Elongation factor Tu GTP binding domain 11 276 9.9E-53 T 21-04-2016 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 Gene3D G3DSA:2.40.30.10 291 393 2.5E-20 T 21-04-2016 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PANTHER PTHR23115 250 486 3.3E-219 T 21-04-2016 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 PANTHER PTHR23115 1 182 3.3E-219 T 21-04-2016 SPH21_RS18155 ea36e0697f0b6631df09439fa0f6ad63 528 SUPERFAMILY SSF52540 7 276 2.05E-85 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24035 08f740bb837727891903f2098007630a 134 Gene3D G3DSA:3.10.129.10 35 119 4.1E-4 T 21-04-2016 IPR029069 HotDog domain SPH21_RS24035 08f740bb837727891903f2098007630a 134 SUPERFAMILY SSF54637 2 125 1.43E-9 T 21-04-2016 IPR029069 HotDog domain SPH21_RS06815 b9cc2e2814cb3112bc0e0b78a6d2b2d8 257 Pfam PF05690 Thiazole biosynthesis protein ThiG 6 249 4.7E-105 T 21-04-2016 SPH21_RS06815 b9cc2e2814cb3112bc0e0b78a6d2b2d8 257 Hamap MF_00443 Thiazole synthase [thiG]. 4 255 42.332 T 21-04-2016 IPR008867 Thiazole biosynthesis GO:0009228 KEGG: 00730+2.8.1.10|MetaCyc: PWY-6891|MetaCyc: PWY-6892|UniPathway: UPA00060 SPH21_RS06815 b9cc2e2814cb3112bc0e0b78a6d2b2d8 257 PANTHER PTHR34266 1 254 1.6E-147 T 21-04-2016 SPH21_RS06815 b9cc2e2814cb3112bc0e0b78a6d2b2d8 257 Gene3D G3DSA:3.20.20.70 5 254 9.2E-62 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS06815 b9cc2e2814cb3112bc0e0b78a6d2b2d8 257 SUPERFAMILY SSF110399 4 237 3.66E-82 T 21-04-2016 IPR008867 Thiazole biosynthesis GO:0009228 KEGG: 00730+2.8.1.10|MetaCyc: PWY-6891|MetaCyc: PWY-6892|UniPathway: UPA00060 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 TIGRFAM TIGR02095 glgA: glycogen/starch synthase, ADP-glucose type 1 471 1.2E-132 T 21-04-2016 IPR011835 Bacterial/plant glycogen synthase GO:0004373 KEGG: 00500+2.4.1.21|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 Pfam PF08323 Starch synthase catalytic domain 2 231 3.2E-53 T 21-04-2016 IPR013534 Starch synthase, catalytic domain KEGG: 00500+2.4.1.21|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 SUPERFAMILY SSF53756 1 472 1.54E-86 T 21-04-2016 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 PANTHER PTHR12526 1 473 5.9E-102 T 21-04-2016 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 PANTHER PTHR12526:SF17 1 473 5.9E-102 T 21-04-2016 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 Gene3D G3DSA:3.40.50.2000 246 451 5.6E-57 T 21-04-2016 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 Pfam PF00534 Glycosyl transferases group 1 288 433 5.8E-14 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS25285 3e1d3a355ef92d73858c2138381d156c 473 Hamap MF_00484 Glycogen synthase [glgA]. 1 471 34.904 T 21-04-2016 IPR011835 Bacterial/plant glycogen synthase GO:0004373 KEGG: 00500+2.4.1.21|MetaCyc: PWY-622|UniPathway: UPA00164 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 SMART SM00812 30 443 3.4E-109 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 Pfam PF01120 Alpha-L-fucosidase 19 376 9.2E-101 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 PANTHER PTHR10030 47 192 7.9E-73 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 PANTHER PTHR10030 216 492 7.9E-73 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 SUPERFAMILY SSF51445 43 379 3.3E-90 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 Gene3D G3DSA:3.20.20.80 29 379 6.9E-95 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 Gene3D G3DSA:2.60.40.1180 412 489 1.7E-20 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 Pfam PF16757 Alpha-L-fucosidase C-terminal domain 415 489 2.4E-11 T 21-04-2016 IPR031919 Alpha-L-fucosidase, C-terminal KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 PIRSF PIRSF001092 4 490 3.1E-108 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 PRINTS PR00741 Glycosyl hydrolase family 29 signature 362 384 1.3E-20 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 PRINTS PR00741 Glycosyl hydrolase family 29 signature 329 350 1.3E-20 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS23180 1ca539fe3f7104100dc348a129338c77 493 PRINTS PR00741 Glycosyl hydrolase family 29 signature 126 142 1.3E-20 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14030 5e79ae889c667efbf0b0e7fd53e695e7 172 Pfam PF13673 Acetyltransferase (GNAT) domain 42 148 9.8E-20 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS14030 5e79ae889c667efbf0b0e7fd53e695e7 172 PANTHER PTHR23091 1 165 3.8E-25 T 21-04-2016 SPH21_RS14030 5e79ae889c667efbf0b0e7fd53e695e7 172 Gene3D G3DSA:3.40.630.30 1 153 2.6E-36 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS14030 5e79ae889c667efbf0b0e7fd53e695e7 172 SUPERFAMILY SSF55729 1 165 5.24E-30 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS14030 5e79ae889c667efbf0b0e7fd53e695e7 172 PANTHER PTHR23091:SF264 1 165 3.8E-25 T 21-04-2016 SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PANTHER PTHR24322:SF397 152 183 8.5E-52 T 21-04-2016 SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PANTHER PTHR24322:SF397 11 136 8.5E-52 T 21-04-2016 SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 3.4E-18 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 3.4E-18 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 3.4E-18 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 3.4E-18 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.4E-18 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 Pfam PF00106 short chain dehydrogenase 7 192 6.5E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PANTHER PTHR24322 152 183 8.5E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PANTHER PTHR24322 11 136 8.5E-52 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 SUPERFAMILY SSF51735 5 246 1.21E-59 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 5.8E-6 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 5.8E-6 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 5.8E-6 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS04475 16cb996320f9a040b8d019b3bd264719 279 Gene3D G3DSA:3.40.50.720 6 243 6.1E-61 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23070 fd64b1c596b2d6386bf1d42f4700f297 162 Hamap MF_01114 Regulatory protein RecX [recX]. 4 161 11.275 T 21-04-2016 IPR003783 Regulatory protein RecX GO:0006282 SPH21_RS23070 fd64b1c596b2d6386bf1d42f4700f297 162 Gene3D G3DSA:1.10.10.10 16 62 1.4E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23070 fd64b1c596b2d6386bf1d42f4700f297 162 Gene3D G3DSA:1.10.10.10 63 106 6.2E-6 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23070 fd64b1c596b2d6386bf1d42f4700f297 162 Pfam PF02631 RecX family 46 158 1.0E-21 T 21-04-2016 IPR003783 Regulatory protein RecX GO:0006282 SPH21_RS23070 fd64b1c596b2d6386bf1d42f4700f297 162 PANTHER PTHR33602 14 157 8.7E-22 T 21-04-2016 SPH21_RS00740 c61370eb76687e5e156aa495a7dba0e3 454 Pfam PF07980 SusD family 319 454 4.0E-25 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS00740 c61370eb76687e5e156aa495a7dba0e3 454 Pfam PF14322 Starch-binding associating with outer membrane 35 221 2.4E-27 T 21-04-2016 SPH21_RS00740 c61370eb76687e5e156aa495a7dba0e3 454 Gene3D G3DSA:1.25.40.10 202 401 1.5E-29 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00740 c61370eb76687e5e156aa495a7dba0e3 454 SUPERFAMILY SSF48452 17 454 4.08E-101 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PANTHER PTHR10422:SF6 1 517 2.7E-197 T 21-04-2016 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 Gene3D G3DSA:1.20.210.10 2 559 7.2E-173 T 21-04-2016 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 2 479 1.2E-134 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 125 137 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 54 77 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 160 178 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 296 311 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 82 106 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 433 454 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 320 341 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 383 402 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PRINTS PR01165 Cytochrome c oxidase subunit I signature 355 373 3.9E-66 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 SUPERFAMILY SSF81442 2 532 3.79E-148 T 21-04-2016 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 252 306 - T 21-04-2016 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS07695 2421682f8abdea5c79fb869d30b26d0f 592 PANTHER PTHR10422 1 517 2.7E-197 T 21-04-2016 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|UniPathway: UPA00705 SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 PANTHER PTHR12110:SF21 1 246 1.4E-16 T 21-04-2016 SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 PANTHER PTHR12110:SF21 269 361 1.4E-16 T 21-04-2016 SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 Pfam PF01261 Xylose isomerase-like TIM barrel 26 247 5.2E-13 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 SUPERFAMILY SSF51658 271 341 6.77E-28 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 SUPERFAMILY SSF51658 14 238 6.77E-28 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 Gene3D G3DSA:3.20.20.150 276 330 1.7E-25 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 Gene3D G3DSA:3.20.20.150 7 238 1.7E-25 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 PANTHER PTHR12110 1 246 1.4E-16 T 21-04-2016 SPH21_RS14825 f38c91849858bad6c9eddf39fdf6154f 378 PANTHER PTHR12110 269 361 1.4E-16 T 21-04-2016 SPH21_RS13670 a4c0f1841eea6426cdc731ab44deea05 370 Pfam PF02469 Fasciclin domain 56 204 1.1E-6 T 21-04-2016 IPR000782 FAS1 domain SPH21_RS13670 a4c0f1841eea6426cdc731ab44deea05 370 Gene3D G3DSA:2.30.180.10 42 204 1.6E-9 T 21-04-2016 IPR000782 FAS1 domain SPH21_RS13670 a4c0f1841eea6426cdc731ab44deea05 370 SUPERFAMILY SSF82153 41 204 1.05E-8 T 21-04-2016 IPR000782 FAS1 domain SPH21_RS13670 a4c0f1841eea6426cdc731ab44deea05 370 SUPERFAMILY SSF49785 251 354 3.12E-11 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS13670 a4c0f1841eea6426cdc731ab44deea05 370 Gene3D G3DSA:2.60.120.260 244 363 1.7E-8 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS22295 f1720c04c8d54766f399035fba97af2c 117 SUPERFAMILY SSF54909 16 108 3.75E-14 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS22295 f1720c04c8d54766f399035fba97af2c 117 Gene3D G3DSA:3.30.70.1060 1 109 9.3E-21 T 21-04-2016 SPH21_RS22295 f1720c04c8d54766f399035fba97af2c 117 Pfam PF03795 YCII-related domain 42 108 3.9E-12 T 21-04-2016 IPR005545 YCII-related SPH21_RS03380 02acb77c0a59debf75860f4634f4eeaf 214 Gene3D G3DSA:3.90.470.20 22 118 2.4E-11 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS03380 02acb77c0a59debf75860f4634f4eeaf 214 SUPERFAMILY SSF56214 23 99 4.92E-9 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS03380 02acb77c0a59debf75860f4634f4eeaf 214 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 108 168 2.6E-9 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS03380 02acb77c0a59debf75860f4634f4eeaf 214 Gene3D G3DSA:3.90.470.20 119 164 1.4E-10 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS03380 02acb77c0a59debf75860f4634f4eeaf 214 SUPERFAMILY SSF56214 106 161 1.44E-11 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS03165 9cc72df782da9943ecbdd863eac4b0be 794 SUPERFAMILY SSF48208 289 766 1.26E-88 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS03165 9cc72df782da9943ecbdd863eac4b0be 794 Gene3D G3DSA:2.70.98.50 31 417 3.5E-127 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS03165 9cc72df782da9943ecbdd863eac4b0be 794 PANTHER PTHR31084:SF0 26 777 1.5E-267 T 21-04-2016 SPH21_RS03165 9cc72df782da9943ecbdd863eac4b0be 794 PANTHER PTHR31084 26 777 1.5E-267 T 21-04-2016 SPH21_RS03165 9cc72df782da9943ecbdd863eac4b0be 794 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 32 279 1.5E-62 T 21-04-2016 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SPH21_RS03165 9cc72df782da9943ecbdd863eac4b0be 794 PIRSF PIRSF007663 11 793 2.9E-258 T 21-04-2016 IPR016518 Alpha-L-fucosidase GO:0004560 KEGG: 00511+3.2.1.51 SPH21_RS05095 2a2d6c512ad7ea58cd72c9207387da0c 379 SUPERFAMILY SSF53383 8 376 2.64E-105 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS05095 2a2d6c512ad7ea58cd72c9207387da0c 379 Pfam PF00202 Aminotransferase class-III 12 373 7.7E-97 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS05095 2a2d6c512ad7ea58cd72c9207387da0c 379 PANTHER PTHR11986 1 379 7.7E-128 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS05095 2a2d6c512ad7ea58cd72c9207387da0c 379 Gene3D G3DSA:3.90.1150.10 275 376 1.3E-26 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS05095 2a2d6c512ad7ea58cd72c9207387da0c 379 Gene3D G3DSA:3.40.640.10 46 274 3.4E-71 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS05095 2a2d6c512ad7ea58cd72c9207387da0c 379 PANTHER PTHR11986:SF79 1 379 7.7E-128 T 21-04-2016 SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 Gene3D G3DSA:2.40.440.10 330 376 1.9E-9 T 21-04-2016 SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 Gene3D G3DSA:2.40.440.10 424 472 1.9E-9 T 21-04-2016 SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 SUPERFAMILY SSF141523 331 385 2.88E-18 T 21-04-2016 SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 SUPERFAMILY SSF141523 422 472 2.88E-18 T 21-04-2016 SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 Gene3D G3DSA:1.10.101.10 238 313 3.9E-12 T 21-04-2016 IPR002477 Peptidoglycan binding-like SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 PANTHER PTHR41533 40 547 4.8E-88 T 21-04-2016 SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 Pfam PF01471 Putative peptidoglycan binding domain 252 302 8.3E-5 T 21-04-2016 IPR002477 Peptidoglycan binding-like SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 SUPERFAMILY SSF47090 234 312 2.59E-12 T 21-04-2016 IPR002477 Peptidoglycan binding-like SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 Pfam PF03734 L,D-transpeptidase catalytic domain 332 482 3.7E-29 T 21-04-2016 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 UniPathway: UPA00219 SPH21_RS01770 fdaa1a72ea98b21faf070924ec5c0810 548 PANTHER PTHR41533:SF1 40 547 4.8E-88 T 21-04-2016 SPH21_RS04825 cfab2730985e37d80ceaf722d42eac9e 384 Gene3D G3DSA:1.20.1090.10 186 384 1.5E-61 T 21-04-2016 SPH21_RS04825 cfab2730985e37d80ceaf722d42eac9e 384 PANTHER PTHR11496 12 384 1.4E-112 T 21-04-2016 SPH21_RS04825 cfab2730985e37d80ceaf722d42eac9e 384 PANTHER PTHR11496:SF68 12 384 1.4E-112 T 21-04-2016 SPH21_RS04825 cfab2730985e37d80ceaf722d42eac9e 384 Pfam PF00465 Iron-containing alcohol dehydrogenase 12 375 7.2E-112 T 21-04-2016 IPR001670 Alcohol dehydrogenase, iron-type GO:0016491|GO:0046872|GO:0055114 SPH21_RS04825 cfab2730985e37d80ceaf722d42eac9e 384 SUPERFAMILY SSF56796 9 384 1.96E-113 T 21-04-2016 SPH21_RS04825 cfab2730985e37d80ceaf722d42eac9e 384 Gene3D G3DSA:3.40.50.1970 8 185 7.5E-48 T 21-04-2016 SPH21_RS24625 f2a8d054f5304a5bf5efd42d010f71e8 298 Pfam PF01613 Flavin reductase like domain 26 169 8.6E-12 T 21-04-2016 IPR002563 Flavin reductase like domain GO:0010181 SPH21_RS24625 f2a8d054f5304a5bf5efd42d010f71e8 298 Gene3D G3DSA:2.30.110.10 20 194 3.3E-55 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS24625 f2a8d054f5304a5bf5efd42d010f71e8 298 SUPERFAMILY SSF50475 5 196 7.36E-40 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS24625 f2a8d054f5304a5bf5efd42d010f71e8 298 SMART SM00903 22 176 1.2E-8 T 21-04-2016 IPR002563 Flavin reductase like domain GO:0010181 SPH21_RS24625 f2a8d054f5304a5bf5efd42d010f71e8 298 PANTHER PTHR33798 1 226 3.4E-50 T 21-04-2016 SPH21_RS09310 93010a9fe561ad2fa283e28bea6c4c68 548 SUPERFAMILY SSF48452 19 546 2.88E-100 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09310 93010a9fe561ad2fa283e28bea6c4c68 548 Pfam PF07980 SusD family 288 546 2.0E-35 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09310 93010a9fe561ad2fa283e28bea6c4c68 548 Gene3D G3DSA:1.25.40.10 402 488 7.0E-39 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09310 93010a9fe561ad2fa283e28bea6c4c68 548 Gene3D G3DSA:1.25.40.10 211 320 7.0E-39 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09310 93010a9fe561ad2fa283e28bea6c4c68 548 Pfam PF14322 Starch-binding associating with outer membrane 70 231 1.6E-20 T 21-04-2016 SPH21_RS05765 00c10d1dc8bef0a84f7d69f496217d77 416 PANTHER PTHR32347:SF14 1 408 2.5E-47 T 21-04-2016 SPH21_RS05765 00c10d1dc8bef0a84f7d69f496217d77 416 PANTHER PTHR32347 1 408 2.5E-47 T 21-04-2016 SPH21_RS05765 00c10d1dc8bef0a84f7d69f496217d77 416 Pfam PF13437 HlyD family secretion protein 234 328 8.7E-6 T 21-04-2016 SPH21_RS05765 00c10d1dc8bef0a84f7d69f496217d77 416 Gene3D G3DSA:2.40.50.100 231 257 3.2E-5 T 21-04-2016 SPH21_RS05765 00c10d1dc8bef0a84f7d69f496217d77 416 Gene3D G3DSA:2.40.50.100 78 106 3.2E-5 T 21-04-2016 SPH21_RS23000 ab59dd4df2bd1679ec8c240949bcb3de 318 Pfam PF01476 LysM domain 126 168 2.6E-10 T 21-04-2016 IPR018392 LysM domain SPH21_RS23000 ab59dd4df2bd1679ec8c240949bcb3de 318 SUPERFAMILY SSF54106 124 168 8.5E-10 T 21-04-2016 IPR018392 LysM domain SPH21_RS23000 ab59dd4df2bd1679ec8c240949bcb3de 318 Gene3D G3DSA:3.10.350.10 43 87 9.4E-4 T 21-04-2016 IPR018392 LysM domain SPH21_RS23000 ab59dd4df2bd1679ec8c240949bcb3de 318 SMART SM00257 125 168 4.0E-12 T 21-04-2016 IPR018392 LysM domain SPH21_RS23000 ab59dd4df2bd1679ec8c240949bcb3de 318 SMART SM00257 45 86 0.21 T 21-04-2016 IPR018392 LysM domain SPH21_RS23000 ab59dd4df2bd1679ec8c240949bcb3de 318 Gene3D G3DSA:3.10.350.10 124 169 1.1E-15 T 21-04-2016 IPR018392 LysM domain SPH21_RS03645 6fd85036b606ca7d9cb16ee9b0ecc79d 302 PANTHER PTHR23024:SF41 52 300 5.5E-62 T 21-04-2016 SPH21_RS03645 6fd85036b606ca7d9cb16ee9b0ecc79d 302 SUPERFAMILY SSF53474 62 298 4.95E-37 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS03645 6fd85036b606ca7d9cb16ee9b0ecc79d 302 Pfam PF07859 alpha/beta hydrolase fold 80 278 3.3E-13 T 21-04-2016 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SPH21_RS03645 6fd85036b606ca7d9cb16ee9b0ecc79d 302 Gene3D G3DSA:3.40.50.1820 58 299 1.9E-68 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS03645 6fd85036b606ca7d9cb16ee9b0ecc79d 302 PANTHER PTHR23024 52 300 5.5E-62 T 21-04-2016 SPH21_RS22660 d7759660f28beefedcf47b4c53cfc43a 415 SUPERFAMILY SSF50939 59 409 1.07E-65 T 21-04-2016 IPR011040 Sialidases SPH21_RS22660 d7759660f28beefedcf47b4c53cfc43a 415 PANTHER PTHR10628:SF5 38 415 1.1E-50 T 21-04-2016 SPH21_RS22660 d7759660f28beefedcf47b4c53cfc43a 415 PANTHER PTHR10628 38 415 1.1E-50 T 21-04-2016 IPR026856 Sialidase family GO:0004308 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS22660 d7759660f28beefedcf47b4c53cfc43a 415 Gene3D G3DSA:2.120.10.10 51 409 5.0E-70 T 21-04-2016 IPR011040 Sialidases SPH21_RS22660 d7759660f28beefedcf47b4c53cfc43a 415 Pfam PF13088 BNR repeat-like domain 83 361 1.2E-20 T 21-04-2016 IPR011040 Sialidases SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 Gene3D G3DSA:3.40.50.1820 36 335 8.0E-63 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 PANTHER PTHR17630:SF49 17 176 1.7E-84 T 21-04-2016 SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 PANTHER PTHR17630:SF49 196 335 1.7E-84 T 21-04-2016 SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 SUPERFAMILY SSF53474 31 177 1.09E-43 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 SUPERFAMILY SSF53474 224 331 1.09E-43 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 Pfam PF12146 Serine aminopeptidase, S33 82 310 1.3E-8 T 21-04-2016 IPR022742 Serine aminopeptidase, S33 SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 PANTHER PTHR17630 17 176 1.7E-84 T 21-04-2016 SPH21_RS00595 c5dd8d4a84930d56405307341fa6a1d4 335 PANTHER PTHR17630 196 335 1.7E-84 T 21-04-2016 SPH21_RS21970 3d1fa60ea1aa5caefeec6adaa8840418 282 SUPERFAMILY SSF46689 222 271 1.88E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21970 3d1fa60ea1aa5caefeec6adaa8840418 282 Gene3D G3DSA:1.10.10.60 223 276 3.2E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21970 3d1fa60ea1aa5caefeec6adaa8840418 282 Gene3D G3DSA:1.10.10.60 174 221 3.9E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21970 3d1fa60ea1aa5caefeec6adaa8840418 282 PANTHER PTHR11019 173 275 1.4E-21 T 21-04-2016 SPH21_RS21970 3d1fa60ea1aa5caefeec6adaa8840418 282 SMART SM00342 185 267 2.9E-22 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21970 3d1fa60ea1aa5caefeec6adaa8840418 282 SUPERFAMILY SSF46689 175 220 6.72E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21970 3d1fa60ea1aa5caefeec6adaa8840418 282 Pfam PF12833 Helix-turn-helix domain 196 268 1.9E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 SUPERFAMILY SSF55874 324 491 4.32E-39 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 SMART SM00388 266 334 1.5E-11 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 382 491 9.3E-20 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 Gene3D G3DSA:3.30.565.10 336 491 5.0E-39 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 Pfam PF00512 His Kinase A (phospho-acceptor) domain 267 330 3.1E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 SMART SM00387 381 492 5.0E-26 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 SUPERFAMILY SSF47384 253 334 1.04E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 Gene3D G3DSA:1.10.287.130 259 329 4.1E-12 T 21-04-2016 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 PANTHER PTHR24423 138 150 3.9E-56 T 21-04-2016 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 PANTHER PTHR24423 259 491 3.9E-56 T 21-04-2016 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 418 432 4.1E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 436 446 4.1E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 477 490 4.1E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS26410 df557ee2bae545f5d543127d1b2ed9e4 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 453 471 4.1E-15 T 21-04-2016 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 SPH21_RS19065 4202d302ba69ea18f2e5acf691261658 211 Gene3D G3DSA:1.10.10.10 104 203 3.0E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19065 4202d302ba69ea18f2e5acf691261658 211 SUPERFAMILY SSF46894 137 202 4.42E-13 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS19065 4202d302ba69ea18f2e5acf691261658 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 185 3.7E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS19065 4202d302ba69ea18f2e5acf691261658 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 157 173 3.7E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS19065 4202d302ba69ea18f2e5acf691261658 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 143 157 3.7E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS19065 4202d302ba69ea18f2e5acf691261658 211 Pfam PF00196 Bacterial regulatory proteins, luxR family 143 195 4.3E-11 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS19065 4202d302ba69ea18f2e5acf691261658 211 SMART SM00421 140 197 2.8E-6 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS02645 365103b271352aa2574a047efe51f6d9 281 Pfam PF01569 PAP2 superfamily 136 248 1.1E-17 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS02645 365103b271352aa2574a047efe51f6d9 281 SMART SM00014 133 246 1.8E-4 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS02645 365103b271352aa2574a047efe51f6d9 281 SUPERFAMILY SSF48317 66 256 1.83E-26 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS02645 365103b271352aa2574a047efe51f6d9 281 Gene3D G3DSA:1.20.144.10 96 260 1.8E-25 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 Pfam PF07664 Ferrous iron transport protein B C terminus 453 505 1.4E-17 T 21-04-2016 IPR011640 Ferrous iron transport protein B, C-terminal GO:0015093|GO:0015684|GO:0016021 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 Pfam PF02421 Ferrous iron transport protein B 2 161 1.2E-58 T 21-04-2016 IPR011619 Ferrous iron transport protein B, N-terminal GO:0005525|GO:0015093|GO:0015684|GO:0016021 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 Gene3D G3DSA:3.40.50.300 2 164 6.8E-38 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 SUPERFAMILY SSF52540 1 164 2.49E-42 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PANTHER PTHR11649 566 700 1.4E-229 T 21-04-2016 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PANTHER PTHR11649 1 148 1.4E-229 T 21-04-2016 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PANTHER PTHR11649 257 537 1.4E-229 T 21-04-2016 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 Pfam PF07670 Nucleoside recognition 341 430 5.1E-14 T 21-04-2016 IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain Reactome: REACT_15518|Reactome: REACT_1698 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 Pfam PF07670 Nucleoside recognition 510 674 1.3E-28 T 21-04-2016 IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain Reactome: REACT_15518|Reactome: REACT_1698 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PANTHER PTHR11649:SF37 566 700 1.4E-229 T 21-04-2016 IPR003373 Ferrous iron transport protein B GO:0005525|GO:0015093|GO:0015684|GO:0016021 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PANTHER PTHR11649:SF37 1 148 1.4E-229 T 21-04-2016 IPR003373 Ferrous iron transport protein B GO:0005525|GO:0015093|GO:0015684|GO:0016021 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PANTHER PTHR11649:SF37 257 537 1.4E-229 T 21-04-2016 IPR003373 Ferrous iron transport protein B GO:0005525|GO:0015093|GO:0015684|GO:0016021 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 1 156 1.2E-13 T 21-04-2016 IPR005225 Small GTP-binding protein domain GO:0005525 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 TIGRFAM TIGR00437 feoB: ferrous iron transport protein B 7 670 7.3E-166 T 21-04-2016 IPR003373 Ferrous iron transport protein B GO:0005525|GO:0015093|GO:0015684|GO:0016021 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 24 42 2.5E-7 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS10825 8d76e51ead2479fc7fb46bf7710acaa0 700 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 3 23 2.5E-7 T 21-04-2016 IPR006073 GTP binding domain GO:0005525 SPH21_RS24895 e0afcc9224ec9a5d1ef220eb70cd3e5d 507 PANTHER PTHR40254 7 507 5.5E-52 T 21-04-2016 SPH21_RS24895 e0afcc9224ec9a5d1ef220eb70cd3e5d 507 Gene3D G3DSA:3.50.50.60 378 454 3.0E-6 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24895 e0afcc9224ec9a5d1ef220eb70cd3e5d 507 Gene3D G3DSA:3.50.50.60 216 270 3.0E-6 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24895 e0afcc9224ec9a5d1ef220eb70cd3e5d 507 SUPERFAMILY SSF51905 8 249 2.78E-15 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24895 e0afcc9224ec9a5d1ef220eb70cd3e5d 507 Gene3D G3DSA:3.50.50.60 6 215 1.9E-12 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24895 e0afcc9224ec9a5d1ef220eb70cd3e5d 507 Pfam PF13454 FAD-NAD(P)-binding 10 173 2.2E-30 T 21-04-2016 SPH21_RS24895 e0afcc9224ec9a5d1ef220eb70cd3e5d 507 PANTHER PTHR40254:SF1 7 507 5.5E-52 T 21-04-2016 SPH21_RS05265 7fbe38bf322d297f5a52b87e0c36712d 282 TIGRFAM TIGR00216 ispH_lytB: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 9 281 4.8E-64 T 21-04-2016 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 UniPathway: UPA00056|UniPathway: UPA00059 SPH21_RS05265 7fbe38bf322d297f5a52b87e0c36712d 282 PANTHER PTHR30426 4 282 1.1E-92 T 21-04-2016 SPH21_RS05265 7fbe38bf322d297f5a52b87e0c36712d 282 Pfam PF02401 LytB protein 8 279 5.3E-83 T 21-04-2016 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 UniPathway: UPA00056|UniPathway: UPA00059 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 PANTHER PTHR11532 534 1057 5.8E-263 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 PANTHER PTHR11532 44 425 5.8E-263 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 PANTHER PTHR11532:SF57 534 1057 5.8E-263 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 PANTHER PTHR11532:SF57 44 425 5.8E-263 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Gene3D G3DSA:2.60.40.1120 58 142 9.1E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 SUPERFAMILY SSF49464 57 138 5.76E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 SUPERFAMILY SSF56935 882 926 2.2E-91 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 SUPERFAMILY SSF56935 964 1059 2.2E-91 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 SUPERFAMILY SSF56935 461 805 2.2E-91 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 SUPERFAMILY SSF56935 337 425 2.2E-91 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 SUPERFAMILY SSF56935 137 277 2.2E-91 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 228 258 3.2E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Gene3D G3DSA:2.170.130.10 143 252 6.8E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Pfam PF07715 TonB-dependent Receptor Plug Domain 149 252 6.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Pfam PF13715 CarboxypepD_reg-like domain 59 140 8.2E-18 T 21-04-2016 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Gene3D G3DSA:2.40.170.20 891 916 3.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Gene3D G3DSA:2.40.170.20 253 273 3.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Gene3D G3DSA:2.40.170.20 346 829 3.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 Gene3D G3DSA:2.40.170.20 954 1059 3.1E-52 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13190 16069d876ee1a554d380410cfc86df14 1059 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 57 1059 1.9E-271 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS07870 64eed8d6e06a4b85fbef6e0e0437483f 411 ProSitePatterns PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 61 72 - T 21-04-2016 IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site GO:0016651|GO:0055114 SPH21_RS07870 64eed8d6e06a4b85fbef6e0e0437483f 411 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 17 411 44.599 T 21-04-2016 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 SPH21_RS07870 64eed8d6e06a4b85fbef6e0e0437483f 411 Gene3D G3DSA:1.10.645.10 21 385 4.9E-50 T 21-04-2016 IPR029014 NiFe hydrogenase-like SPH21_RS07870 64eed8d6e06a4b85fbef6e0e0437483f 411 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 138 410 2.3E-106 T 21-04-2016 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 SPH21_RS07870 64eed8d6e06a4b85fbef6e0e0437483f 411 SUPERFAMILY SSF56762 34 410 2.62E-113 T 21-04-2016 IPR029014 NiFe hydrogenase-like SPH21_RS07870 64eed8d6e06a4b85fbef6e0e0437483f 411 PANTHER PTHR11993 25 406 2.8E-156 T 21-04-2016 SPH21_RS07870 64eed8d6e06a4b85fbef6e0e0437483f 411 PANTHER PTHR11993:SF10 25 406 2.8E-156 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 Gene3D G3DSA:3.30.2090.10 184 263 2.7E-10 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PANTHER PTHR32063 535 1062 1.5E-235 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PANTHER PTHR32063 1 493 1.5E-235 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PRINTS PR00702 Acriflavin resistance protein family signature 437 460 7.0E-32 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PRINTS PR00702 Acriflavin resistance protein family signature 356 377 7.0E-32 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PRINTS PR00702 Acriflavin resistance protein family signature 462 485 7.0E-32 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PRINTS PR00702 Acriflavin resistance protein family signature 329 352 7.0E-32 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PRINTS PR00702 Acriflavin resistance protein family signature 38 56 7.0E-32 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PRINTS PR00702 Acriflavin resistance protein family signature 10 34 7.0E-32 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PRINTS PR00702 Acriflavin resistance protein family signature 384 408 7.0E-32 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 SUPERFAMILY SSF82714 183 263 8.11E-10 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 SUPERFAMILY SSF82693 267 323 2.07E-14 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 SUPERFAMILY SSF82693 135 181 2.07E-14 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 Gene3D G3DSA:1.10.3850.10 275 490 1.6E-51 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 Gene3D G3DSA:1.10.3850.10 857 1063 2.7E-43 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PANTHER PTHR32063:SF8 535 1062 1.5E-235 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 PANTHER PTHR32063:SF8 1 493 1.5E-235 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 Gene3D G3DSA:3.30.70.1430 41 138 4.3E-10 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 Gene3D G3DSA:3.30.2090.10 754 844 1.8E-10 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 SUPERFAMILY SSF82866 290 489 3.79E-39 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 SUPERFAMILY SSF82866 852 1064 1.83E-38 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 SUPERFAMILY SSF82714 755 843 1.44E-8 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 SUPERFAMILY SSF82693 41 134 2.88E-12 T 21-04-2016 SPH21_RS20140 e0e1059d08bab2fd54121f7dc7282f96 1092 Pfam PF00873 AcrB/AcrD/AcrF family 4 1062 1.2E-181 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS00250 f27f3989de93eed30acf23acf1013992 413 SUPERFAMILY SSF53383 36 401 2.99E-82 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS00250 f27f3989de93eed30acf23acf1013992 413 Gene3D G3DSA:3.90.1150.10 283 398 2.1E-14 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS00250 f27f3989de93eed30acf23acf1013992 413 Gene3D G3DSA:3.40.640.10 63 282 6.2E-68 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS00250 f27f3989de93eed30acf23acf1013992 413 PANTHER PTHR13693 28 401 2.8E-102 T 21-04-2016 SPH21_RS00250 f27f3989de93eed30acf23acf1013992 413 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 246 255 - T 21-04-2016 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SPH21_RS00250 f27f3989de93eed30acf23acf1013992 413 Pfam PF00155 Aminotransferase class I and II 45 388 8.3E-35 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS12680 c3aed3f5ce856f1522d1411f218e984d 295 PANTHER PTHR17630:SF32 84 295 3.1E-58 T 21-04-2016 SPH21_RS12680 c3aed3f5ce856f1522d1411f218e984d 295 PANTHER PTHR17630 84 295 3.1E-58 T 21-04-2016 SPH21_RS12680 c3aed3f5ce856f1522d1411f218e984d 295 Pfam PF01738 Dienelactone hydrolase family 84 293 1.0E-51 T 21-04-2016 IPR002925 Dienelactone hydrolase GO:0016787 SPH21_RS12680 c3aed3f5ce856f1522d1411f218e984d 295 SUPERFAMILY SSF53474 71 294 9.35E-47 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12680 c3aed3f5ce856f1522d1411f218e984d 295 Gene3D G3DSA:3.40.50.1820 71 295 1.3E-58 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS05495 e5df44950ad7360bbde0e85c71524d32 349 PANTHER PTHR30238:SF0 100 346 7.6E-124 T 21-04-2016 IPR022369 Integral membrane protein TerC, riboswitch-linked GO:0016021 SPH21_RS05495 e5df44950ad7360bbde0e85c71524d32 349 PANTHER PTHR30238:SF0 2 62 7.6E-124 T 21-04-2016 IPR022369 Integral membrane protein TerC, riboswitch-linked GO:0016021 SPH21_RS05495 e5df44950ad7360bbde0e85c71524d32 349 TIGRFAM TIGR03718 R_switched_Alx: integral membrane protein, TerC family 5 345 2.6E-112 T 21-04-2016 IPR022369 Integral membrane protein TerC, riboswitch-linked GO:0016021 SPH21_RS05495 e5df44950ad7360bbde0e85c71524d32 349 PANTHER PTHR30238 100 346 7.6E-124 T 21-04-2016 SPH21_RS05495 e5df44950ad7360bbde0e85c71524d32 349 PANTHER PTHR30238 2 62 7.6E-124 T 21-04-2016 SPH21_RS05495 e5df44950ad7360bbde0e85c71524d32 349 Pfam PF03741 Integral membrane protein TerC family 106 310 1.6E-56 T 21-04-2016 IPR005496 Integral membrane protein TerC GO:0016021 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Gene3D G3DSA:1.25.40.20 113 196 5.4E-27 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 PRINTS PR01415 Ankyrin repeat signature 149 163 7.1E-8 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 PRINTS PR01415 Ankyrin repeat signature 35 50 7.1E-8 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Pfam PF12796 Ankyrin repeats (3 copies) 302 391 2.1E-11 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Pfam PF12796 Ankyrin repeats (3 copies) 105 195 3.4E-13 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Pfam PF12796 Ankyrin repeats (3 copies) 6 65 1.4E-11 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 67 96 0.81 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 34 63 4.1E-7 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 166 195 0.0035 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 133 162 0.39 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 232 261 4.7 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 297 326 0.26 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 330 359 5.4E-6 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 363 392 860.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 100 129 0.0076 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SMART SM00248 199 228 280.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SUPERFAMILY SSF48403 203 391 1.78E-25 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Gene3D G3DSA:1.25.40.20 6 112 3.5E-31 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 SUPERFAMILY SSF48403 6 256 2.92E-60 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Pfam PF09851 Short C-terminal domain 419 445 1.4E-7 T 21-04-2016 IPR018649 SHOCT domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 PANTHER PTHR24123 6 271 5.8E-88 T 21-04-2016 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 PANTHER PTHR24123 300 391 5.8E-88 T 21-04-2016 SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Gene3D G3DSA:1.25.40.20 197 261 2.3E-37 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS12115 aa9f3351a7255d56ed2378c2870d01b0 447 Gene3D G3DSA:1.25.40.20 294 389 2.3E-37 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS13055 a8ac88c6caad9f07dafe2203bc578c75 269 Gene3D G3DSA:2.10.110.10 149 184 9.7E-4 T 21-04-2016 IPR001781 Zinc finger, LIM-type GO:0008270 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Gene3D G3DSA:2.170.130.10 117 228 1.8E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 PANTHER PTHR11532 1007 1021 1.9E-231 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 PANTHER PTHR11532 450 991 1.9E-231 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 PANTHER PTHR11532 7 348 1.9E-231 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Gene3D G3DSA:2.60.40.1120 32 116 7.9E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 32 1023 4.6E-240 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 SUPERFAMILY SSF49464 30 111 3.53E-17 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Pfam PF13715 CarboxypepD_reg-like domain 32 113 3.4E-19 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 SUPERFAMILY SSF56935 110 253 1.47E-83 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 SUPERFAMILY SSF56935 920 969 1.47E-83 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 SUPERFAMILY SSF56935 419 766 1.47E-83 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 SUPERFAMILY SSF56935 837 880 1.47E-83 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 SUPERFAMILY SSF56935 294 382 1.47E-83 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Pfam PF07715 TonB-dependent Receptor Plug Domain 121 228 5.4E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 PANTHER PTHR11532:SF57 1007 1021 1.9E-231 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 PANTHER PTHR11532:SF57 450 991 1.9E-231 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 PANTHER PTHR11532:SF57 7 348 1.9E-231 T 21-04-2016 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Gene3D G3DSA:2.40.170.20 845 1000 4.0E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Gene3D G3DSA:2.40.170.20 229 249 4.0E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Gene3D G3DSA:2.40.170.20 804 805 4.0E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 Gene3D G3DSA:2.40.170.20 303 764 4.0E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS13135 0f655db01195d29c47441e7a03eacb77 1023 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 204 233 2.0E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS03910 daac89e4a37ae1a97c64fc446d9030f1 377 PANTHER PTHR33886:SF2 30 376 6.4E-93 T 21-04-2016 SPH21_RS03910 daac89e4a37ae1a97c64fc446d9030f1 377 Pfam PF07470 Glycosyl Hydrolase Family 88 35 372 1.1E-84 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS03910 daac89e4a37ae1a97c64fc446d9030f1 377 Gene3D G3DSA:1.50.10.10 23 374 6.5E-83 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS03910 daac89e4a37ae1a97c64fc446d9030f1 377 PANTHER PTHR33886 30 376 6.4E-93 T 21-04-2016 SPH21_RS03910 daac89e4a37ae1a97c64fc446d9030f1 377 SUPERFAMILY SSF48208 49 373 3.29E-47 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS11320 8e43dedf42552ff164e4bcdaa17f3c60 235 SUPERFAMILY SSF55120 12 224 1.02E-55 T 21-04-2016 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11320 8e43dedf42552ff164e4bcdaa17f3c60 235 PANTHER PTHR11079:SF83 13 233 1.2E-63 T 21-04-2016 SPH21_RS11320 8e43dedf42552ff164e4bcdaa17f3c60 235 Pfam PF00849 RNA pseudouridylate synthase 19 174 4.0E-35 T 21-04-2016 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11320 8e43dedf42552ff164e4bcdaa17f3c60 235 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 64 78 - T 21-04-2016 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS11320 8e43dedf42552ff164e4bcdaa17f3c60 235 PANTHER PTHR11079 13 233 1.2E-63 T 21-04-2016 SPH21_RS20525 feac3f25435b0ccad128632013e110a0 171 Gene3D G3DSA:2.40.30.100 2 92 1.9E-17 T 21-04-2016 SPH21_RS20525 feac3f25435b0ccad128632013e110a0 171 Pfam PF13376 Bacteriocin-protection, YdeI or OmpD-Associated 97 154 2.2E-16 T 21-04-2016 SPH21_RS20525 feac3f25435b0ccad128632013e110a0 171 Pfam PF08922 Domain of unknown function (DUF1905) 4 89 7.8E-19 T 21-04-2016 IPR015018 Protein of unknown function DUF1905 SPH21_RS20525 feac3f25435b0ccad128632013e110a0 171 SUPERFAMILY SSF141694 2 91 1.39E-11 T 21-04-2016 SPH21_RS03595 43df9d1b87d80e0ac181523a644472c8 280 Pfam PF04962 KduI/IolB family 35 265 2.1E-32 T 21-04-2016 IPR021120 KduI/IolB isomerase GO:0016861 KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507|UniPathway: UPA00545 SPH21_RS03595 43df9d1b87d80e0ac181523a644472c8 280 PIRSF PIRSF006625 5 280 6.2E-134 T 21-04-2016 IPR007045 5-keto 4-deoxyuronate isomerase GO:0008697|GO:0045490 KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507|UniPathway: UPA00545 SPH21_RS03595 43df9d1b87d80e0ac181523a644472c8 280 Gene3D G3DSA:2.60.120.520 24 134 1.0E-54 T 21-04-2016 IPR027449 5-keto-4-deoxyuronate isomerase, N-terminal domain KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507|UniPathway: UPA00545 SPH21_RS03595 43df9d1b87d80e0ac181523a644472c8 280 Gene3D G3DSA:2.60.120.500 135 280 4.5E-75 T 21-04-2016 IPR027447 5-keto-4-deoxyuronate isomerase, C-terminal domain KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507|UniPathway: UPA00545 SPH21_RS03595 43df9d1b87d80e0ac181523a644472c8 280 PANTHER PTHR38461 2 280 1.2E-167 T 21-04-2016 SPH21_RS03595 43df9d1b87d80e0ac181523a644472c8 280 Hamap MF_00687 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [kduI]. 5 280 55.239 T 21-04-2016 IPR007045 5-keto 4-deoxyuronate isomerase GO:0008697|GO:0045490 KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507|UniPathway: UPA00545 SPH21_RS03595 43df9d1b87d80e0ac181523a644472c8 280 SUPERFAMILY SSF51182 5 264 5.57E-109 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS08810 825d645f7fc14c0840d1b67a53ed55fd 400 PANTHER PTHR22926:SF3 253 369 1.9E-72 T 21-04-2016 SPH21_RS08810 825d645f7fc14c0840d1b67a53ed55fd 400 PANTHER PTHR22926:SF3 1 236 1.9E-72 T 21-04-2016 SPH21_RS08810 825d645f7fc14c0840d1b67a53ed55fd 400 Pfam PF00953 Glycosyl transferase family 4 78 231 4.0E-35 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS08810 825d645f7fc14c0840d1b67a53ed55fd 400 PANTHER PTHR22926 253 369 1.9E-72 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS08810 825d645f7fc14c0840d1b67a53ed55fd 400 PANTHER PTHR22926 1 236 1.9E-72 T 21-04-2016 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|UniPathway: UPA00219 SPH21_RS14730 2fa3ff417b15eb64a528b3039b06c30a 151 Pfam PF01042 Endoribonuclease L-PSP 49 150 2.3E-18 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS14730 2fa3ff417b15eb64a528b3039b06c30a 151 Gene3D G3DSA:3.30.1330.40 49 151 1.8E-33 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS14730 2fa3ff417b15eb64a528b3039b06c30a 151 PANTHER PTHR11803 54 151 8.4E-22 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS14730 2fa3ff417b15eb64a528b3039b06c30a 151 SUPERFAMILY SSF55298 44 151 3.77E-28 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS13510 7e3ddf08b5f67e5cebb89fafa779e076 202 Gene3D G3DSA:3.10.300.10 6 201 6.2E-69 T 21-04-2016 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 SPH21_RS13510 7e3ddf08b5f67e5cebb89fafa779e076 202 PANTHER PTHR10429:SF0 3 201 1.7E-72 T 21-04-2016 SPH21_RS13510 7e3ddf08b5f67e5cebb89fafa779e076 202 TIGRFAM TIGR00567 3mg: DNA-3-methyladenine glycosylase 7 200 1.1E-57 T 21-04-2016 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 SPH21_RS13510 7e3ddf08b5f67e5cebb89fafa779e076 202 SUPERFAMILY SSF50486 6 201 8.63E-64 T 21-04-2016 IPR011034 Formyl transferase, C-terminal-like GO:0003824 SPH21_RS13510 7e3ddf08b5f67e5cebb89fafa779e076 202 Pfam PF02245 Methylpurine-DNA glycosylase (MPG) 13 197 2.1E-58 T 21-04-2016 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 SPH21_RS13510 7e3ddf08b5f67e5cebb89fafa779e076 202 Hamap MF_00527 Putative 3-methyladenine DNA glycosylase. 9 200 30.929 T 21-04-2016 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 SPH21_RS13510 7e3ddf08b5f67e5cebb89fafa779e076 202 PANTHER PTHR10429 3 201 1.7E-72 T 21-04-2016 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 SPH21_RS02745 fc708db2a4a8c8d57d03409f5981fc59 145 PANTHER PTHR33221 1 139 9.4E-50 T 21-04-2016 SPH21_RS02745 fc708db2a4a8c8d57d03409f5981fc59 145 PANTHER PTHR33221:SF1 1 139 9.4E-50 T 21-04-2016 SPH21_RS02745 fc708db2a4a8c8d57d03409f5981fc59 145 Gene3D G3DSA:1.10.10.10 1 140 1.2E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02745 fc708db2a4a8c8d57d03409f5981fc59 145 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 1 136 1.1E-34 T 21-04-2016 IPR000944 Transcription regulator Rrf2-type SPH21_RS02745 fc708db2a4a8c8d57d03409f5981fc59 145 SUPERFAMILY SSF46785 1 137 4.39E-31 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02745 fc708db2a4a8c8d57d03409f5981fc59 145 Pfam PF02082 Transcriptional regulator 1 81 2.4E-25 T 21-04-2016 IPR000944 Transcription regulator Rrf2-type SPH21_RS14890 ae3e2d6eaf7954669684b8ccfb3682e3 268 Gene3D G3DSA:3.30.2010.10 74 151 7.8E-14 T 21-04-2016 SPH21_RS14890 ae3e2d6eaf7954669684b8ccfb3682e3 268 Pfam PF01435 Peptidase family M48 76 257 1.2E-33 T 21-04-2016 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SPH21_RS14890 ae3e2d6eaf7954669684b8ccfb3682e3 268 PANTHER PTHR22726 8 268 6.7E-69 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 PANTHER PTHR32439:SF0 56 275 4.5E-90 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 PANTHER PTHR32439:SF0 292 548 4.5E-90 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Gene3D G3DSA:3.90.480.10 314 389 3.1E-30 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Gene3D G3DSA:3.90.480.10 51 120 3.1E-30 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Pfam PF05168 HEPN domain 583 664 1.4E-7 T 21-04-2016 IPR007842 HEPN domain SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 321 386 1.6E-10 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 48 113 3.9E-20 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 ProSitePatterns PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 445 461 - T 21-04-2016 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 396 541 1.9E-10 T 21-04-2016 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 123 273 1.2E-33 T 21-04-2016 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Gene3D G3DSA:3.30.413.10 123 273 4.0E-37 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 SUPERFAMILY SSF56014 395 559 1.83E-32 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 PANTHER PTHR32439 56 275 4.5E-90 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 PANTHER PTHR32439 292 548 4.5E-90 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 SUPERFAMILY SSF55124 255 279 2.13E-17 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 SUPERFAMILY SSF55124 308 409 2.13E-17 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 SUPERFAMILY SSF56014 123 273 1.22E-44 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Gene3D G3DSA:1.20.120.330 580 657 7.8E-13 T 21-04-2016 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 PRINTS PR00397 Sirohaem Fe-binding site signature 445 463 4.3E-5 T 21-04-2016 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 PRINTS PR00397 Sirohaem Fe-binding site signature 398 416 4.3E-5 T 21-04-2016 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 SUPERFAMILY SSF55124 20 122 3.34E-25 T 21-04-2016 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683|UniPathway: UPA00140 SPH21_RS15890 eb5fa8c6c50337ec2fbf33f59e8b6414 697 Gene3D G3DSA:3.30.413.10 395 541 9.3E-28 T 21-04-2016 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 SUPERFAMILY SSF88946 4 98 2.51E-24 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 179 6.0E-28 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 Gene3D G3DSA:1.10.1740.10 4 105 1.8E-25 T 21-04-2016 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 Pfam PF04542 Sigma-70 region 2 26 90 8.0E-16 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 PANTHER PTHR30173 1 193 2.6E-42 T 21-04-2016 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 Pfam PF08281 Sigma-70, region 4 127 175 5.2E-16 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 PANTHER PTHR30173:SF20 1 193 2.6E-42 T 21-04-2016 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 Gene3D G3DSA:1.10.10.10 119 179 1.9E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 SUPERFAMILY SSF88659 114 179 2.8E-14 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS08230 53f8052a4c47b7cfebb0bb4bed025d35 193 TIGRFAM TIGR02985 Sig70_bacteroi1: RNA polymerase sigma-70 factor, Bacteroides expansion family 1 22 179 2.0E-42 T 21-04-2016 IPR014327 RNA polymerase sigma-70, Bacteroidetes type SPH21_RS06995 61d7f252999e8466853aac2813c19a53 455 Pfam PF10091 Putative glucoamylase 218 437 9.5E-86 T 21-04-2016 IPR019282 Domain of unknown function DUF2329 SPH21_RS06995 61d7f252999e8466853aac2813c19a53 455 PIRSF PIRSF028431 3 454 8.2E-157 T 21-04-2016 IPR016883 Uncharacterised conserved protein UCP028431 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 Gene3D G3DSA:2.70.98.10 22 317 1.1E-88 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 Gene3D G3DSA:1.20.1050.60 346 433 3.8E-30 T 21-04-2016 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 PANTHER PTHR12143 1 759 0.0 T 21-04-2016 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 PANTHER PTHR12143:SF22 1 759 0.0 T 21-04-2016 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 Gene3D G3DSA:1.20.1610.10 440 597 3.7E-59 T 21-04-2016 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 12 737 9.5E-206 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 SUPERFAMILY SSF48208 271 720 3.91E-23 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 Pfam PF07971 Glycosyl hydrolase family 92 238 733 3.0E-156 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS00870 b9110234d19e87f75afc8632f9cf1c7c 759 Gene3D G3DSA:3.30.2080.10 598 744 1.1E-64 T 21-04-2016 SPH21_RS19435 df02391f1c5807b0eb7775e1f0fe59dd 153 Pfam PF00578 AhpC/TSA family 7 134 1.9E-43 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS19435 df02391f1c5807b0eb7775e1f0fe59dd 153 Gene3D G3DSA:3.40.30.10 2 151 5.6E-51 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS19435 df02391f1c5807b0eb7775e1f0fe59dd 153 PIRSF PIRSF000239 1 153 1.7E-28 T 21-04-2016 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15 SPH21_RS19435 df02391f1c5807b0eb7775e1f0fe59dd 153 SUPERFAMILY SSF52833 4 153 9.53E-51 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS19435 df02391f1c5807b0eb7775e1f0fe59dd 153 PANTHER PTHR10681 1 141 3.9E-54 T 21-04-2016 SPH21_RS03840 b056766d6e9bad430ff925ba615f5927 189 Pfam PF03729 Short repeat of unknown function (DUF308) 137 182 2.3E-5 T 21-04-2016 IPR005325 Protein of unknown function DUF308, membrane SPH21_RS03840 b056766d6e9bad430ff925ba615f5927 189 Pfam PF03729 Short repeat of unknown function (DUF308) 78 149 2.1E-9 T 21-04-2016 IPR005325 Protein of unknown function DUF308, membrane SPH21_RS03840 b056766d6e9bad430ff925ba615f5927 189 Pfam PF03729 Short repeat of unknown function (DUF308) 20 81 2.2E-10 T 21-04-2016 IPR005325 Protein of unknown function DUF308, membrane SPH21_RS25390 086b3e4db4e8f5433343cfd19763642d 399 PIRSF PIRSF005700 21 399 6.1E-31 T 21-04-2016 IPR004134 Peptidase C1B, bleomycin hydrolase GO:0004197|GO:0006508 SPH21_RS25390 086b3e4db4e8f5433343cfd19763642d 399 ProSitePatterns PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 61 72 - T 21-04-2016 IPR000169 Cysteine peptidase, cysteine active site SPH21_RS25390 086b3e4db4e8f5433343cfd19763642d 399 Gene3D G3DSA:3.90.70.10 51 398 5.9E-78 T 21-04-2016 SPH21_RS25390 086b3e4db4e8f5433343cfd19763642d 399 Pfam PF03051 Peptidase C1-like family 26 396 9.8E-13 T 21-04-2016 IPR004134 Peptidase C1B, bleomycin hydrolase GO:0004197|GO:0006508 SPH21_RS25390 086b3e4db4e8f5433343cfd19763642d 399 SUPERFAMILY SSF54001 50 393 1.58E-41 T 21-04-2016 SPH21_RS05445 123a2cded90b8050b5ed16182dca3934 337 PANTHER PTHR11203 8 198 4.0E-58 T 21-04-2016 SPH21_RS05445 123a2cded90b8050b5ed16182dca3934 337 PANTHER PTHR11203:SF35 8 198 4.0E-58 T 21-04-2016 SPH21_RS05445 123a2cded90b8050b5ed16182dca3934 337 SUPERFAMILY SSF56281 10 315 1.3E-56 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS05445 123a2cded90b8050b5ed16182dca3934 337 TIGRFAM TIGR04122 Xnuc_lig_assoc: putative exonuclease, DNA ligase-associated 1 325 7.6E-132 T 21-04-2016 IPR026360 Putative exonuclease, DNA ligase-associated SPH21_RS05445 123a2cded90b8050b5ed16182dca3934 337 Gene3D G3DSA:3.60.15.10 23 190 3.6E-16 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 Gene3D G3DSA:1.20.1250.20 17 218 2.4E-16 T 21-04-2016 SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 SUPERFAMILY SSF103473 17 429 1.27E-32 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 PANTHER PTHR23514:SF10 11 176 8.8E-163 T 21-04-2016 SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 PANTHER PTHR23514:SF10 195 432 8.8E-163 T 21-04-2016 SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 Pfam PF07690 Major Facilitator Superfamily 22 372 1.2E-15 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 PANTHER PTHR23514 11 176 8.8E-163 T 21-04-2016 SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 PANTHER PTHR23514 195 432 8.8E-163 T 21-04-2016 SPH21_RS14145 049da7ba5732f62252d66a43a5b6b33d 435 TIGRFAM TIGR01272 gluP: glucose/galactose transporter WARNING 98 424 7.1E-70 T 21-04-2016 IPR005964 Bacterial glucose/galactose transporter GO:0005354|GO:0005355|GO:0009276|GO:0015757|GO:0015758|GO:0016021 SPH21_RS11185 75252b060e1c017df258914528e58b8a 130 Gene3D G3DSA:3.40.1560.10 4 120 5.0E-5 T 21-04-2016 IPR012297 Restriction endonuclease EcoO109IR, catalytic domain SPH21_RS11185 75252b060e1c017df258914528e58b8a 130 SUPERFAMILY SSF54427 2 109 2.1E-9 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS12250 fab536c221a57b483292156c16a78025 393 PANTHER PTHR18919 1 393 6.4E-216 T 21-04-2016 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 PIRSF PIRSF000429 1 393 9.8E-122 T 21-04-2016 IPR002155 Thiolase GO:0008152|GO:0016747 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 SUPERFAMILY SSF53901 270 391 2.28E-39 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 Pfam PF00108 Thiolase, N-terminal domain 5 261 7.9E-95 T 21-04-2016 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 ProSitePatterns PS00099 Thiolases active site. 373 386 - T 21-04-2016 IPR020610 Thiolase, active site GO:0008152|GO:0016747 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 SUPERFAMILY SSF53901 4 269 6.26E-79 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 7 390 1.5E-130 T 21-04-2016 IPR002155 Thiolase GO:0008152|GO:0016747 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 ProSitePatterns PS00737 Thiolases signature 2. 338 354 - T 21-04-2016 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 Gene3D G3DSA:3.40.47.10 144 193 6.4E-58 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 Gene3D G3DSA:3.40.47.10 276 391 6.4E-58 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 Gene3D G3DSA:3.40.47.10 4 123 1.6E-67 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 Gene3D G3DSA:3.40.47.10 194 275 1.6E-67 T 21-04-2016 IPR016039 Thiolase-like GO:0003824|GO:0008152 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 PANTHER PTHR18919:SF81 1 393 6.4E-216 T 21-04-2016 SPH21_RS12250 fab536c221a57b483292156c16a78025 393 Pfam PF02803 Thiolase, C-terminal domain 270 391 6.6E-45 T 21-04-2016 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SPH21_RS18805 db2d0f66baf2b3da90842258859d6649 482 PIRSF PIRSF006060 3 481 4.6E-74 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS18805 db2d0f66baf2b3da90842258859d6649 482 PANTHER PTHR11785:SF26 6 476 8.8E-238 T 21-04-2016 SPH21_RS18805 db2d0f66baf2b3da90842258859d6649 482 PANTHER PTHR11785 6 476 8.8E-238 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS18805 db2d0f66baf2b3da90842258859d6649 482 ProSitePatterns PS00218 Amino acid permeases signature. 47 77 - T 21-04-2016 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 SPH21_RS18805 db2d0f66baf2b3da90842258859d6649 482 Pfam PF00324 Amino acid permease 22 469 3.4E-111 T 21-04-2016 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 Gene3D G3DSA:3.20.20.80 111 442 1.2E-83 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 Gene3D G3DSA:3.20.20.80 489 517 1.2E-83 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 SUPERFAMILY SSF81296 10 96 4.8E-15 T 21-04-2016 IPR014756 Immunoglobulin E-set SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 PANTHER PTHR10357 4 319 4.8E-100 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 PANTHER PTHR10357 340 468 4.8E-100 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 PANTHER PTHR10357 497 606 4.8E-100 T 21-04-2016 IPR015902 Glycoside hydrolase, family 13 GO:0003824 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 TIGRFAM TIGR02402 trehalose_TreZ: malto-oligosyltrehalose trehalohydrolase 22 557 4.5E-211 T 21-04-2016 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902|UniPathway: UPA00299 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 SUPERFAMILY SSF51445 93 518 1.7E-106 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 SMART SM00642 117 512 5.4E-10 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 PIRSF PIRSF006337 7 585 1.1E-211 T 21-04-2016 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902|UniPathway: UPA00299 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 Gene3D G3DSA:2.60.40.10 14 94 1.4E-21 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 Pfam PF11941 Domain of unknown function (DUF3459) 504 581 1.0E-7 T 21-04-2016 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 Pfam PF00128 Alpha amylase, catalytic domain 127 214 9.1E-18 T 21-04-2016 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 PANTHER PTHR10357:SF110 4 319 4.8E-100 T 21-04-2016 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 PANTHER PTHR10357:SF110 340 468 4.8E-100 T 21-04-2016 SPH21_RS01535 e3f907ea89dd4277f6b23d5c2f89d6c8 609 PANTHER PTHR10357:SF110 497 606 4.8E-100 T 21-04-2016 SPH21_RS24745 fc8cf3daa2a30bb57656eb1f02af5f14 180 PANTHER PTHR12083 19 53 6.1E-15 T 21-04-2016 SPH21_RS24745 fc8cf3daa2a30bb57656eb1f02af5f14 180 PANTHER PTHR12083 77 175 6.1E-15 T 21-04-2016 SPH21_RS24745 fc8cf3daa2a30bb57656eb1f02af5f14 180 Gene3D G3DSA:3.40.50.300 19 168 1.4E-19 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24745 fc8cf3daa2a30bb57656eb1f02af5f14 180 SUPERFAMILY SSF52540 19 146 9.11E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24745 fc8cf3daa2a30bb57656eb1f02af5f14 180 Pfam PF13671 AAA domain 21 165 2.9E-19 T 21-04-2016 SPH21_RS23265 16a1cc4ad710d251d8052f23f169c54c 189 Gene3D G3DSA:1.10.760.10 59 152 2.7E-17 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS23265 16a1cc4ad710d251d8052f23f169c54c 189 SUPERFAMILY SSF46626 55 175 4.73E-18 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS23265 16a1cc4ad710d251d8052f23f169c54c 189 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III 72 149 2.3E-10 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS03895 24b869a1ccedefd620b92cffac6541ad 479 Gene3D G3DSA:2.120.10.10 191 292 1.5E-5 T 21-04-2016 IPR011040 Sialidases SPH21_RS03895 24b869a1ccedefd620b92cffac6541ad 479 Pfam PF15892 BNR repeat-containing family member 99 358 7.2E-94 T 21-04-2016 SPH21_RS03895 24b869a1ccedefd620b92cffac6541ad 479 SUPERFAMILY SSF50939 190 288 8.63E-5 T 21-04-2016 IPR011040 Sialidases SPH21_RS03895 24b869a1ccedefd620b92cffac6541ad 479 Gene3D G3DSA:2.120.10.10 87 173 4.9E-5 T 21-04-2016 IPR011040 Sialidases SPH21_RS08650 85d60bc1c28f47ed4f22f339c4a068bf 124 SMART SM00905 8 120 8.9E-20 T 21-04-2016 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS08650 85d60bc1c28f47ed4f22f339c4a068bf 124 TIGRFAM TIGR00525 folB: dihydroneopterin aldolase 7 118 1.3E-24 T 21-04-2016 IPR006156 Dihydroneopterin aldolase GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS08650 85d60bc1c28f47ed4f22f339c4a068bf 124 Gene3D G3DSA:3.30.1130.10 7 119 1.9E-25 T 21-04-2016 SPH21_RS08650 85d60bc1c28f47ed4f22f339c4a068bf 124 TIGRFAM TIGR00526 folB_dom: FolB domain 7 122 1.7E-15 T 21-04-2016 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS08650 85d60bc1c28f47ed4f22f339c4a068bf 124 SUPERFAMILY SSF55620 7 120 1.11E-21 T 21-04-2016 SPH21_RS08650 85d60bc1c28f47ed4f22f339c4a068bf 124 Pfam PF02152 Dihydroneopterin aldolase 8 118 2.3E-23 T 21-04-2016 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539|UniPathway: UPA00077 SPH21_RS26005 37d8af10525d42816b12b4b771774804 131 Pfam PF01381 Helix-turn-helix 7 62 3.7E-12 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS26005 37d8af10525d42816b12b4b771774804 131 Gene3D G3DSA:1.10.260.40 1 67 6.6E-15 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS26005 37d8af10525d42816b12b4b771774804 131 SMART SM00530 6 62 4.2E-8 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS26005 37d8af10525d42816b12b4b771774804 131 SUPERFAMILY SSF47413 1 66 3.66E-11 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 Pfam PF02687 FtsX-like permease family 289 400 6.8E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 Pfam PF02687 FtsX-like permease family 670 781 9.5E-9 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 Pfam PF12704 MacB-like periplasmic core domain 21 245 1.7E-18 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 Pfam PF12704 MacB-like periplasmic core domain 441 630 2.0E-7 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 PANTHER PTHR30572:SF4 400 790 9.9E-76 T 21-04-2016 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 PANTHER PTHR30572:SF4 241 355 9.9E-76 T 21-04-2016 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 PANTHER PTHR30572:SF4 10 216 9.9E-76 T 21-04-2016 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 PANTHER PTHR30572 400 790 9.9E-76 T 21-04-2016 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 PANTHER PTHR30572 241 355 9.9E-76 T 21-04-2016 SPH21_RS05785 2575cb71b62c48bcafa6926801fcee07 790 PANTHER PTHR30572 10 216 9.9E-76 T 21-04-2016 SPH21_RS02040 3f63ed18e13d3339925b26cc9fd03d96 168 PANTHER PTHR10681:SF125 1 150 3.0E-19 T 21-04-2016 SPH21_RS02040 3f63ed18e13d3339925b26cc9fd03d96 168 Gene3D G3DSA:3.40.30.10 5 167 3.1E-43 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02040 3f63ed18e13d3339925b26cc9fd03d96 168 ProSitePatterns PS00194 Thioredoxin family active site. 56 74 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS02040 3f63ed18e13d3339925b26cc9fd03d96 168 PANTHER PTHR10681 1 150 3.0E-19 T 21-04-2016 SPH21_RS02040 3f63ed18e13d3339925b26cc9fd03d96 168 Pfam PF08534 Redoxin 28 162 3.6E-23 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS02040 3f63ed18e13d3339925b26cc9fd03d96 168 SUPERFAMILY SSF52833 25 167 6.82E-35 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS13835 c802f142d9251e0a3a886e0052d6e137 403 PANTHER PTHR36845:SF1 69 403 5.9E-87 T 21-04-2016 SPH21_RS13835 c802f142d9251e0a3a886e0052d6e137 403 PANTHER PTHR36845 69 403 5.9E-87 T 21-04-2016 SPH21_RS13835 c802f142d9251e0a3a886e0052d6e137 403 SUPERFAMILY SSF48208 48 401 1.02E-94 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS13835 c802f142d9251e0a3a886e0052d6e137 403 Pfam PF07470 Glycosyl Hydrolase Family 88 71 349 3.6E-21 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS13835 c802f142d9251e0a3a886e0052d6e137 403 Gene3D G3DSA:1.50.10.10 32 400 1.0E-136 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS00805 a50dec786b50d2f50fb5103314ebdd3e 186 PANTHER PTHR33678:SF1 31 173 2.5E-21 T 21-04-2016 SPH21_RS00805 a50dec786b50d2f50fb5103314ebdd3e 186 Pfam PF13007 Transposase C of IS166 homeodomain 2 67 1.3E-11 T 21-04-2016 IPR024463 Transposase TnpC, homeodomain SPH21_RS00805 a50dec786b50d2f50fb5103314ebdd3e 186 Pfam PF03050 Transposase IS66 family 126 174 8.6E-12 T 21-04-2016 IPR004291 Transposase, IS66 SPH21_RS00805 a50dec786b50d2f50fb5103314ebdd3e 186 PANTHER PTHR33678 31 173 2.5E-21 T 21-04-2016 SPH21_RS00805 a50dec786b50d2f50fb5103314ebdd3e 186 Pfam PF13005 zinc-finger binding domain of transposase IS66 77 107 4.1E-7 T 21-04-2016 IPR024474 Zinc-finger binding domain of transposase IS66 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 SUPERFAMILY SSF53756 1 390 5.03E-63 T 21-04-2016 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 Gene3D G3DSA:3.40.50.2000 224 372 4.1E-26 T 21-04-2016 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 PANTHER PTHR11926 1 364 6.1E-29 T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 PANTHER PTHR11926:SF16 1 364 6.1E-29 T 21-04-2016 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 Gene3D G3DSA:3.40.50.2000 1 137 1.5E-16 T 21-04-2016 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 ProSitePatterns PS00375 UDP-glycosyltransferases signature. 282 323 - T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 10 387 1.9E-48 T 21-04-2016 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SPH21_RS18480 ce4e01ede23dbc20552caa1b1d1742b4 398 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 217 366 3.9E-13 T 21-04-2016 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SPH21_RS06210 e5de369243e23e44cbbc3c8ef60807e7 502 SUPERFAMILY SSF51004 211 316 4.19E-27 T 21-04-2016 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain SPH21_RS06210 e5de369243e23e44cbbc3c8ef60807e7 502 SUPERFAMILY SSF51004 34 184 4.19E-27 T 21-04-2016 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain SPH21_RS06210 e5de369243e23e44cbbc3c8ef60807e7 502 Gene3D G3DSA:2.130.10.10 34 315 3.9E-34 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS06210 e5de369243e23e44cbbc3c8ef60807e7 502 Gene3D G3DSA:2.130.10.10 439 500 3.9E-34 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS06210 e5de369243e23e44cbbc3c8ef60807e7 502 PANTHER PTHR21588 79 448 3.9E-60 T 21-04-2016 SPH21_RS06210 e5de369243e23e44cbbc3c8ef60807e7 502 PANTHER PTHR21588:SF5 79 448 3.9E-60 T 21-04-2016 SPH21_RS19915 2bbfaf9d8b99e218312dce6f84c6ba7c 139 SUPERFAMILY SSF82649 7 135 3.03E-43 T 21-04-2016 SPH21_RS19915 2bbfaf9d8b99e218312dce6f84c6ba7c 139 Pfam PF02657 Fe-S metabolism associated domain 11 129 8.9E-46 T 21-04-2016 IPR003808 Fe-S metabolism associated domain, SufE-like UniPathway: UPA00266 SPH21_RS19915 2bbfaf9d8b99e218312dce6f84c6ba7c 139 PANTHER PTHR12735 1 137 5.2E-45 T 21-04-2016 SPH21_RS19915 2bbfaf9d8b99e218312dce6f84c6ba7c 139 Gene3D G3DSA:3.90.1010.10 1 138 1.1E-51 T 21-04-2016 SPH21_RS19915 2bbfaf9d8b99e218312dce6f84c6ba7c 139 PANTHER PTHR12735:SF11 1 137 5.2E-45 T 21-04-2016 SPH21_RS17000 e37a13e9f8663d7b2358b164b8b3bca0 408 PANTHER PTHR30572 1 408 6.9E-109 T 21-04-2016 SPH21_RS17000 e37a13e9f8663d7b2358b164b8b3bca0 408 PANTHER PTHR30572:SF7 1 408 6.9E-109 T 21-04-2016 SPH21_RS17000 e37a13e9f8663d7b2358b164b8b3bca0 408 Pfam PF12704 MacB-like periplasmic core domain 22 247 9.5E-38 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS17000 e37a13e9f8663d7b2358b164b8b3bca0 408 Pfam PF02687 FtsX-like permease family 289 401 5.5E-19 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS13355 1c4ee0326b6b8d7bda4d58f508418b52 351 SUPERFAMILY SSF103501 39 67 7.72E-16 T 21-04-2016 IPR023234 NarG-like domain SPH21_RS13355 1c4ee0326b6b8d7bda4d58f508418b52 351 SUPERFAMILY SSF103501 101 278 7.72E-16 T 21-04-2016 IPR023234 NarG-like domain SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 PANTHER PTHR28629:SF4 1 539 9.3E-199 T 21-04-2016 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 SMART SM01120 377 540 4.5E-39 T 21-04-2016 IPR004007 DhaL domain GO:0004371|GO:0006071 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 SUPERFAMILY SSF101473 347 539 6.15E-42 T 21-04-2016 IPR004007 DhaL domain GO:0004371|GO:0006071 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 Pfam PF02734 DAK2 domain 377 539 8.5E-39 T 21-04-2016 IPR004007 DhaL domain GO:0004371|GO:0006071 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 Gene3D G3DSA:3.40.50.10440 11 181 1.4E-70 T 21-04-2016 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 Gene3D G3DSA:3.30.1180.20 183 325 3.4E-33 T 21-04-2016 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 SUPERFAMILY SSF82549 1 326 2.88E-105 T 21-04-2016 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 Pfam PF02733 Dak1 domain 23 319 2.4E-102 T 21-04-2016 IPR004006 DhaK domain GO:0004371|GO:0006071 SPH21_RS22445 fbdecb957700320fbb4894c43c7cc173 541 PANTHER PTHR28629 1 539 9.3E-199 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 SMART SM00965 71 122 0.0088 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 Gene3D G3DSA:2.60.40.1120 143 232 4.8E-10 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 SUPERFAMILY SSF56935 982 1026 5.04E-76 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 SUPERFAMILY SSF56935 220 362 5.04E-76 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 SUPERFAMILY SSF56935 1076 1161 5.04E-76 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 SUPERFAMILY SSF56935 428 898 5.04E-76 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 Pfam PF07715 TonB-dependent Receptor Plug Domain 237 338 2.4E-13 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 Gene3D G3DSA:2.40.170.20 979 1042 8.2E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 Gene3D G3DSA:2.40.170.20 438 898 8.2E-30 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 143 1161 6.7E-273 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 SUPERFAMILY SSF49464 143 222 6.41E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 Pfam PF13715 CarboxypepD_reg-like domain 144 224 5.5E-13 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 314 344 1.1E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 PANTHER PTHR11532:SF57 143 549 6.5E-259 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 PANTHER PTHR11532:SF57 625 1159 6.5E-259 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 Gene3D G3DSA:2.170.130.10 237 348 2.7E-14 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 PANTHER PTHR11532 143 549 6.5E-259 T 21-04-2016 SPH21_RS23970 d45c28dcc37e197fda1a92d53dc58227 1161 PANTHER PTHR11532 625 1159 6.5E-259 T 21-04-2016 SPH21_RS09145 b746ef0e9108c6d292827eb1e6aafe43 451 ProSitePatterns PS00194 Thioredoxin family active site. 105 123 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS09145 b746ef0e9108c6d292827eb1e6aafe43 451 SUPERFAMILY SSF52833 63 189 3.67E-16 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS09145 b746ef0e9108c6d292827eb1e6aafe43 451 Pfam PF08534 Redoxin 86 162 2.4E-7 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS09145 b746ef0e9108c6d292827eb1e6aafe43 451 Gene3D G3DSA:3.40.30.10 35 191 8.2E-21 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS16580 b8dfe1c9b3cf56e81e686b9fca9bb626 163 SMART SM00047 24 162 1.2E-4 T 21-04-2016 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SPH21_RS16580 b8dfe1c9b3cf56e81e686b9fca9bb626 163 Pfam PF01832 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase 43 163 4.4E-14 T 21-04-2016 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 Gene3D G3DSA:1.20.1250.20 252 443 9.7E-23 T 21-04-2016 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 Gene3D G3DSA:1.20.1250.20 19 204 2.7E-32 T 21-04-2016 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 PANTHER PTHR23500 12 444 8.7E-158 T 21-04-2016 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 PRINTS PR00171 Sugar transporter signature 261 271 2.6E-20 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 PRINTS PR00171 Sugar transporter signature 369 381 2.6E-20 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 PRINTS PR00171 Sugar transporter signature 346 367 2.6E-20 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 PRINTS PR00171 Sugar transporter signature 107 126 2.6E-20 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 PRINTS PR00171 Sugar transporter signature 24 34 2.6E-20 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 ProSitePatterns PS00216 Sugar transport proteins signature 1. 70 87 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 ProSitePatterns PS00216 Sugar transport proteins signature 1. 305 322 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 SUPERFAMILY SSF103473 8 442 7.85E-76 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 PANTHER PTHR23500:SF22 12 444 8.7E-158 T 21-04-2016 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 8 441 9.3E-109 T 21-04-2016 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 Reactome: REACT_15518 SPH21_RS20595 6e47cb5ac9df3d8410666b6a4013be70 448 Pfam PF00083 Sugar (and other) transporter 17 443 1.5E-111 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS26415 4e77cf6798983941ac63ce5c072234e0 142 Gene3D G3DSA:1.10.10.10 1 54 1.6E-7 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS26415 4e77cf6798983941ac63ce5c072234e0 142 SUPERFAMILY SSF48295 1 61 4.81E-11 T 21-04-2016 IPR010921 Trp repressor/replication initiator GO:0043565 SPH21_RS26415 4e77cf6798983941ac63ce5c072234e0 142 Pfam PF01527 Transposase 3 54 3.4E-8 T 21-04-2016 IPR002514 Transposase IS3/IS911family GO:0003677|GO:0004803|GO:0006313 SPH21_RS26415 4e77cf6798983941ac63ce5c072234e0 142 PANTHER PTHR33215:SF2 1 60 1.3E-16 T 21-04-2016 SPH21_RS26415 4e77cf6798983941ac63ce5c072234e0 142 PANTHER PTHR33215 1 60 1.3E-16 T 21-04-2016 SPH21_RS14080 44b23b4bcf48bb80c6a21af2f37a99a1 300 PANTHER PTHR10584 3 297 4.4E-45 T 21-04-2016 SPH21_RS14080 44b23b4bcf48bb80c6a21af2f37a99a1 300 Gene3D G3DSA:3.40.1190.20 1 288 6.8E-79 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS14080 44b23b4bcf48bb80c6a21af2f37a99a1 300 SUPERFAMILY SSF53613 1 275 4.52E-57 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS14080 44b23b4bcf48bb80c6a21af2f37a99a1 300 Pfam PF00294 pfkB family carbohydrate kinase 4 275 1.7E-27 T 21-04-2016 IPR011611 Carbohydrate kinase PfkB SPH21_RS14080 44b23b4bcf48bb80c6a21af2f37a99a1 300 PANTHER PTHR10584:SF166 3 297 4.4E-45 T 21-04-2016 SPH21_RS04740 4560ac910d23118df357808b501cfef9 359 Pfam PF06580 Histidine kinase 165 241 1.3E-18 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS04740 4560ac910d23118df357808b501cfef9 359 PANTHER PTHR34220 14 357 7.3E-28 T 21-04-2016 SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 74 85 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 123 134 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 Gene3D G3DSA:1.10.1060.10 128 179 4.9E-4 T 21-04-2016 SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 SUPERFAMILY SSF54862 66 159 3.22E-20 T 21-04-2016 SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 Gene3D G3DSA:1.10.1060.10 13 127 1.2E-16 T 21-04-2016 SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 Pfam PF12838 4Fe-4S dicluster domain 74 136 1.1E-8 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 PANTHER PTHR10849 41 173 1.2E-25 T 21-04-2016 SPH21_RS10860 a540421aaf3c720875be498eb16ae36d 187 PANTHER PTHR10849 4 23 1.2E-25 T 21-04-2016 SPH21_RS00015 ba489119d95f3a97b2cd167679193307 145 Gene3D G3DSA:2.60.40.790 10 144 9.8E-39 T 21-04-2016 IPR008978 HSP20-like chaperone SPH21_RS00015 ba489119d95f3a97b2cd167679193307 145 Pfam PF00011 Hsp20/alpha crystallin family 45 144 5.0E-27 T 21-04-2016 IPR002068 Alpha crystallin/Hsp20 domain SPH21_RS00015 ba489119d95f3a97b2cd167679193307 145 SUPERFAMILY SSF49764 22 144 3.35E-35 T 21-04-2016 IPR008978 HSP20-like chaperone SPH21_RS00015 ba489119d95f3a97b2cd167679193307 145 PANTHER PTHR11527:SF122 16 145 3.2E-34 T 21-04-2016 SPH21_RS00015 ba489119d95f3a97b2cd167679193307 145 PANTHER PTHR11527 16 145 3.2E-34 T 21-04-2016 IPR031107 Small heat shock protein HSP20 SPH21_RS25180 71d88c83a36d8b668ff043e810d827a1 344 Gene3D G3DSA:3.40.367.20 117 324 6.7E-60 T 21-04-2016 SPH21_RS25180 71d88c83a36d8b668ff043e810d827a1 344 PANTHER PTHR30514 13 337 1.4E-73 T 21-04-2016 SPH21_RS25180 71d88c83a36d8b668ff043e810d827a1 344 Pfam PF02685 Glucokinase 20 337 1.8E-89 T 21-04-2016 IPR003836 Glucokinase GO:0004340|GO:0005524|GO:0006096|GO:0051156 KEGG: 00010+2.7.1.2|KEGG: 00052+2.7.1.2|KEGG: 00500+2.7.1.2|KEGG: 00520+2.7.1.2|KEGG: 00521+2.7.1.2|KEGG: 00524+2.7.1.2|MetaCyc: PWY-2722|MetaCyc: PWY-2723|MetaCyc: PWY-5514|MetaCyc: PWY-5661|MetaCyc: PWY-621|MetaCyc: PWY-7238|MetaCyc: PWY-7385 SPH21_RS25180 71d88c83a36d8b668ff043e810d827a1 344 SUPERFAMILY SSF53067 19 339 2.77E-47 T 21-04-2016 SPH21_RS25180 71d88c83a36d8b668ff043e810d827a1 344 TIGRFAM TIGR00749 glk: glucokinase 20 335 2.6E-72 T 21-04-2016 IPR003836 Glucokinase GO:0004340|GO:0005524|GO:0006096|GO:0051156 KEGG: 00010+2.7.1.2|KEGG: 00052+2.7.1.2|KEGG: 00500+2.7.1.2|KEGG: 00520+2.7.1.2|KEGG: 00521+2.7.1.2|KEGG: 00524+2.7.1.2|MetaCyc: PWY-2722|MetaCyc: PWY-2723|MetaCyc: PWY-5514|MetaCyc: PWY-5661|MetaCyc: PWY-621|MetaCyc: PWY-7238|MetaCyc: PWY-7385 SPH21_RS25180 71d88c83a36d8b668ff043e810d827a1 344 PANTHER PTHR30514:SF0 13 337 1.4E-73 T 21-04-2016 SPH21_RS01550 21324b638d8f78e3c78f2bc994a9ae77 271 TIGRFAM TIGR00222 panB: 3-methyl-2-oxobutanoate hydroxymethyltransferase 11 271 2.2E-96 T 21-04-2016 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS01550 21324b638d8f78e3c78f2bc994a9ae77 271 Pfam PF02548 Ketopantoate hydroxymethyltransferase 9 266 1.5E-109 T 21-04-2016 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS01550 21324b638d8f78e3c78f2bc994a9ae77 271 PANTHER PTHR20881 7 271 3.1E-136 T 21-04-2016 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS01550 21324b638d8f78e3c78f2bc994a9ae77 271 SUPERFAMILY SSF51621 9 271 9.81E-101 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS01550 21324b638d8f78e3c78f2bc994a9ae77 271 Hamap MF_00156 3-methyl-2-oxobutanoate hydroxymethyltransferase [panB]. 10 271 41.329 T 21-04-2016 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS01550 21324b638d8f78e3c78f2bc994a9ae77 271 Gene3D G3DSA:3.20.20.60 8 271 1.6E-112 T 21-04-2016 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SPH21_RS01550 21324b638d8f78e3c78f2bc994a9ae77 271 PIRSF PIRSF000388 1 271 3.2E-106 T 21-04-2016 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654|UniPathway: UPA00028 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 SUPERFAMILY SSF51445 342 683 3.39E-62 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 Pfam PF00703 Glycosyl hydrolases family 2 251 345 1.3E-11 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 359 518 1.1E-5 T 21-04-2016 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 SUPERFAMILY SSF49303 773 888 2.66E-26 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 SUPERFAMILY SSF49303 687 787 8.63E-17 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 Gene3D G3DSA:2.60.40.320 214 343 5.3E-15 T 21-04-2016 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 PANTHER PTHR10066 30 891 5.8E-192 T 21-04-2016 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 Gene3D G3DSA:2.60.120.260 27 213 4.1E-30 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 PANTHER PTHR10066:SF56 30 891 5.8E-192 T 21-04-2016 IPR028787 Mannosylglycoprotein endo-beta-mannosidase GO:0033947 KEGG: 00040+3.2.1.15|KEGG: 00500+3.2.1.15|MetaCyc: PWY-1081 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 SUPERFAMILY SSF49785 28 226 7.51E-35 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 SUPERFAMILY SSF49303 251 345 1.76E-17 T 21-04-2016 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 Gene3D G3DSA:3.20.20.80 344 572 5.7E-40 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS07160 69ee20f87aab49842a92e688950d7823 891 Gene3D G3DSA:3.20.20.80 619 688 5.7E-40 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS03925 7da01c22918c8cd12e277856e49d8c67 759 Pfam PF14903 WG containing repeat 265 298 4.2E-8 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03925 7da01c22918c8cd12e277856e49d8c67 759 Pfam PF14903 WG containing repeat 230 264 0.047 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03925 7da01c22918c8cd12e277856e49d8c67 759 Pfam PF14903 WG containing repeat 629 665 4.3E-6 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03925 7da01c22918c8cd12e277856e49d8c67 759 Pfam PF14903 WG containing repeat 122 156 2.9E-9 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03925 7da01c22918c8cd12e277856e49d8c67 759 Pfam PF14903 WG containing repeat 705 724 0.076 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03925 7da01c22918c8cd12e277856e49d8c67 759 PANTHER PTHR37841 46 318 1.4E-13 T 21-04-2016 SPH21_RS18395 8ce466fc0b237564164727c197138309 431 PANTHER PTHR32060 270 318 1.4E-14 T 21-04-2016 SPH21_RS18395 8ce466fc0b237564164727c197138309 431 PANTHER PTHR32060 137 227 1.4E-14 T 21-04-2016 SPH21_RS18395 8ce466fc0b237564164727c197138309 431 Pfam PF03572 Peptidase family S41 152 329 2.6E-19 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS18395 8ce466fc0b237564164727c197138309 431 SUPERFAMILY SSF52096 278 372 1.16E-31 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18395 8ce466fc0b237564164727c197138309 431 SUPERFAMILY SSF52096 146 234 1.16E-31 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18395 8ce466fc0b237564164727c197138309 431 SMART SM00245 125 359 0.0022 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS18395 8ce466fc0b237564164727c197138309 431 Gene3D G3DSA:3.90.226.10 147 244 8.0E-34 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18395 8ce466fc0b237564164727c197138309 431 Gene3D G3DSA:3.90.226.10 276 363 8.0E-34 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18395 8ce466fc0b237564164727c197138309 431 PANTHER PTHR32060:SF0 270 318 1.4E-14 T 21-04-2016 SPH21_RS18395 8ce466fc0b237564164727c197138309 431 PANTHER PTHR32060:SF0 137 227 1.4E-14 T 21-04-2016 SPH21_RS17070 446ec8118289944da0d71981e5f726fc 73 Pfam PF11387 Protein of unknown function (DUF2795) 11 56 3.9E-17 T 21-04-2016 IPR021527 Protein of unknown function DUF2795 SPH21_RS05200 2f997ab39e0310238bdb6acfd775112f 248 SUPERFAMILY SSF55681 4 199 4.97E-43 T 21-04-2016 SPH21_RS05200 2f997ab39e0310238bdb6acfd775112f 248 TIGRFAM TIGR00121 birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase 9 237 1.8E-43 T 21-04-2016 IPR004408 Biotin--acetyl-CoA-carboxylase ligase GO:0004077|GO:0006464 SPH21_RS05200 2f997ab39e0310238bdb6acfd775112f 248 Gene3D G3DSA:3.30.930.10 5 199 1.0E-47 T 21-04-2016 SPH21_RS05200 2f997ab39e0310238bdb6acfd775112f 248 Pfam PF03099 Biotin/lipoate A/B protein ligase family 13 140 2.7E-15 T 21-04-2016 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 SPH21_RS05200 2f997ab39e0310238bdb6acfd775112f 248 PANTHER PTHR12835 3 239 9.6E-41 T 21-04-2016 IPR004408 Biotin--acetyl-CoA-carboxylase ligase GO:0004077|GO:0006464 SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 Pfam PF02016 LD-carboxypeptidase 14 287 1.4E-78 T 21-04-2016 IPR003507 Peptidase family S66 SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 PIRSF PIRSF028757 3 300 2.2E-86 T 21-04-2016 IPR003507 Peptidase family S66 SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 SUPERFAMILY SSF141986 142 292 1.44E-40 T 21-04-2016 IPR027461 LD-carboxypeptidase A, C-terminal domain SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 SUPERFAMILY SSF52317 3 161 2.06E-45 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 Gene3D G3DSA:3.50.30.60 163 293 6.2E-39 T 21-04-2016 IPR027461 LD-carboxypeptidase A, C-terminal domain SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 Gene3D G3DSA:3.40.50.10740 4 161 2.0E-46 T 21-04-2016 IPR027478 Murein tetrapeptide carboxypeptidase, N-terminal domain SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 PANTHER PTHR30237:SF2 4 291 2.4E-93 T 21-04-2016 SPH21_RS07020 e62fa7a6b5c68c4c28a97f374f8fcea0 302 PANTHER PTHR30237 4 291 2.4E-93 T 21-04-2016 SPH21_RS00920 cc6de332474c0778e51a0f9c8e825e22 217 Gene3D G3DSA:3.40.50.720 1 217 1.3E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00920 cc6de332474c0778e51a0f9c8e825e22 217 PANTHER PTHR15020:SF29 1 217 4.6E-66 T 21-04-2016 SPH21_RS00920 cc6de332474c0778e51a0f9c8e825e22 217 SUPERFAMILY SSF51735 1 215 1.77E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00920 cc6de332474c0778e51a0f9c8e825e22 217 PANTHER PTHR15020 1 217 4.6E-66 T 21-04-2016 SPH21_RS00920 cc6de332474c0778e51a0f9c8e825e22 217 Pfam PF13460 NAD(P)H-binding 7 205 4.2E-29 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10810 e706eef1fcb0c0b055dc7c79d23ab582 126 Pfam PF01597 Glycine cleavage H-protein 7 124 6.1E-44 T 21-04-2016 IPR002930 Glycine cleavage system H-protein SPH21_RS10810 e706eef1fcb0c0b055dc7c79d23ab582 126 Gene3D G3DSA:2.40.50.100 6 124 2.5E-49 T 21-04-2016 SPH21_RS10810 e706eef1fcb0c0b055dc7c79d23ab582 126 TIGRFAM TIGR00527 gcvH: glycine cleavage system H protein 3 124 6.2E-50 T 21-04-2016 IPR017453 Glycine cleavage system H-protein, subgroup GO:0005960|GO:0019464 SPH21_RS10810 e706eef1fcb0c0b055dc7c79d23ab582 126 Hamap MF_00272 Glycine cleavage system H protein [gcvH]. 4 125 28.885 T 21-04-2016 IPR002930 Glycine cleavage system H-protein SPH21_RS10810 e706eef1fcb0c0b055dc7c79d23ab582 126 PANTHER PTHR11715 1 124 4.1E-62 T 21-04-2016 IPR002930 Glycine cleavage system H-protein SPH21_RS10810 e706eef1fcb0c0b055dc7c79d23ab582 126 SUPERFAMILY SSF51230 2 124 8.38E-44 T 21-04-2016 IPR011053 Single hybrid motif SPH21_RS14710 42384df27bf662c702541b1dbd253b74 340 PIRSF PIRSF018266 1 340 1.4E-42 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS14710 42384df27bf662c702541b1dbd253b74 340 PANTHER PTHR30273:SF2 1 340 1.6E-44 T 21-04-2016 SPH21_RS14710 42384df27bf662c702541b1dbd253b74 340 Pfam PF16344 Domain of unknown function (DUF4974) 238 335 3.8E-18 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS14710 42384df27bf662c702541b1dbd253b74 340 PANTHER PTHR30273 1 340 1.6E-44 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS14710 42384df27bf662c702541b1dbd253b74 340 Pfam PF04773 FecR protein 126 213 2.5E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS08255 bb6d3e08b514a6af49f4afa0ffeb16e9 244 PANTHER PTHR30188 2 244 2.2E-65 T 21-04-2016 IPR030802 ABC transporter permease MalE GO:0006810|GO:0043190 SPH21_RS08255 bb6d3e08b514a6af49f4afa0ffeb16e9 244 Pfam PF02405 Permease MlaE 30 242 1.1E-61 T 21-04-2016 IPR030802 ABC transporter permease MalE GO:0006810|GO:0043190 SPH21_RS08255 bb6d3e08b514a6af49f4afa0ffeb16e9 244 PANTHER PTHR30188:SF4 2 244 2.2E-65 T 21-04-2016 SPH21_RS06805 489e912151a98f7bb262431e5fa0fdcb 338 PANTHER PTHR10953:SF153 22 322 4.6E-78 T 21-04-2016 SPH21_RS06805 489e912151a98f7bb262431e5fa0fdcb 338 Gene3D G3DSA:3.40.50.720 4 240 1.7E-71 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS06805 489e912151a98f7bb262431e5fa0fdcb 338 Pfam PF00581 Rhodanese-like domain 267 327 1.1E-5 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS06805 489e912151a98f7bb262431e5fa0fdcb 338 PANTHER PTHR10953 22 322 4.6E-78 T 21-04-2016 SPH21_RS06805 489e912151a98f7bb262431e5fa0fdcb 338 Gene3D G3DSA:3.40.250.10 256 327 6.7E-13 T 21-04-2016 IPR001763 Rhodanese-like domain SPH21_RS06805 489e912151a98f7bb262431e5fa0fdcb 338 SUPERFAMILY SSF69572 4 321 7.32E-89 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS06805 489e912151a98f7bb262431e5fa0fdcb 338 Pfam PF00899 ThiF family 8 242 2.7E-62 T 21-04-2016 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SPH21_RS17010 e05b95694272f9642c365b6cb4116c3c 390 PANTHER PTHR30572:SF1 1 367 2.2E-88 T 21-04-2016 SPH21_RS17010 e05b95694272f9642c365b6cb4116c3c 390 SUPERFAMILY SSF111369 50 283 3.4E-31 T 21-04-2016 SPH21_RS17010 e05b95694272f9642c365b6cb4116c3c 390 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 49 279 2.6E-24 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS17010 e05b95694272f9642c365b6cb4116c3c 390 PANTHER PTHR30572 1 367 2.2E-88 T 21-04-2016 SPH21_RS17010 e05b95694272f9642c365b6cb4116c3c 390 Gene3D G3DSA:2.40.50.100 167 197 8.2E-17 T 21-04-2016 SPH21_RS17010 e05b95694272f9642c365b6cb4116c3c 390 Gene3D G3DSA:2.40.50.100 59 92 8.2E-17 T 21-04-2016 SPH21_RS17010 e05b95694272f9642c365b6cb4116c3c 390 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 39 365 1.1E-59 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS17930 62eb6825a34ed3abaf0bf1baba6f458e 369 PANTHER PTHR30469 2 366 1.9E-67 T 21-04-2016 SPH21_RS17930 62eb6825a34ed3abaf0bf1baba6f458e 369 PANTHER PTHR30469:SF4 2 366 1.9E-67 T 21-04-2016 SPH21_RS17930 62eb6825a34ed3abaf0bf1baba6f458e 369 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 51 366 1.8E-57 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS17930 62eb6825a34ed3abaf0bf1baba6f458e 369 SUPERFAMILY SSF111369 63 295 3.27E-27 T 21-04-2016 SPH21_RS17930 62eb6825a34ed3abaf0bf1baba6f458e 369 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 73 290 2.1E-27 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS17930 62eb6825a34ed3abaf0bf1baba6f458e 369 Gene3D G3DSA:2.40.50.100 182 213 5.3E-18 T 21-04-2016 SPH21_RS17930 62eb6825a34ed3abaf0bf1baba6f458e 369 Gene3D G3DSA:2.40.50.100 72 106 5.3E-18 T 21-04-2016 SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 Gene3D G3DSA:3.40.50.720 1 250 3.3E-78 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 SUPERFAMILY SSF51735 6 249 1.07E-75 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 1.0E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 131 139 1.0E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 170 1.0E-11 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 1.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 189 1.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 1.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 1.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 170 1.2E-40 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 249 3.1E-56 T 21-04-2016 SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 138 166 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PANTHER PTHR24321:SF6 4 251 6.7E-64 T 21-04-2016 SPH21_RS03090 112eb3969662da706eb58bb173a5159a 254 PANTHER PTHR24321 4 251 6.7E-64 T 21-04-2016 SPH21_RS20900 05cfd2721ac27626a3bf0c2cc11b94ba 197 Gene3D G3DSA:2.60.120.10 6 159 1.1E-36 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS20900 05cfd2721ac27626a3bf0c2cc11b94ba 197 Pfam PF00027 Cyclic nucleotide-binding domain 33 118 2.9E-7 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS20900 05cfd2721ac27626a3bf0c2cc11b94ba 197 PANTHER PTHR24567 17 194 1.5E-18 T 21-04-2016 SPH21_RS20900 05cfd2721ac27626a3bf0c2cc11b94ba 197 SUPERFAMILY SSF51206 20 144 7.73E-23 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS20900 05cfd2721ac27626a3bf0c2cc11b94ba 197 PANTHER PTHR24567:SF33 17 194 1.5E-18 T 21-04-2016 SPH21_RS09275 051f35d14d3a394c222c5a1d61b5ea1d 76 Pfam PF04255 Protein of unknown function (DUF433) 7 62 7.6E-25 T 21-04-2016 IPR007367 Protein of unknown function DUF433 SPH21_RS09275 051f35d14d3a394c222c5a1d61b5ea1d 76 PANTHER PTHR34849 1 67 5.4E-21 T 21-04-2016 SPH21_RS09275 051f35d14d3a394c222c5a1d61b5ea1d 76 SUPERFAMILY SSF46689 3 72 2.69E-23 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09275 051f35d14d3a394c222c5a1d61b5ea1d 76 PANTHER PTHR34849:SF2 1 67 5.4E-21 T 21-04-2016 SPH21_RS09275 051f35d14d3a394c222c5a1d61b5ea1d 76 Gene3D G3DSA:1.10.10.10 6 73 6.2E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09440 a69a59ad2bc90442f32f5fac830704ef 287 PANTHER PTHR18964:SF123 1 274 1.4E-57 T 21-04-2016 SPH21_RS09440 a69a59ad2bc90442f32f5fac830704ef 287 SUPERFAMILY SSF53067 1 274 2.07E-51 T 21-04-2016 SPH21_RS09440 a69a59ad2bc90442f32f5fac830704ef 287 Pfam PF00480 ROK family 3 275 7.0E-45 T 21-04-2016 IPR000600 ROK family SPH21_RS09440 a69a59ad2bc90442f32f5fac830704ef 287 Gene3D G3DSA:3.30.420.40 136 258 7.4E-29 T 21-04-2016 SPH21_RS09440 a69a59ad2bc90442f32f5fac830704ef 287 PANTHER PTHR18964 1 274 1.4E-57 T 21-04-2016 SPH21_RS09440 a69a59ad2bc90442f32f5fac830704ef 287 Gene3D G3DSA:3.30.420.40 1 135 3.6E-40 T 21-04-2016 SPH21_RS10045 8edea9b1188ebb5e7ff347ecbf2d30b4 461 Pfam PF02397 Bacterial sugar transferase 270 454 1.1E-56 T 21-04-2016 IPR003362 Bacterial sugar transferase SPH21_RS10045 8edea9b1188ebb5e7ff347ecbf2d30b4 461 PANTHER PTHR30576 6 461 2.3E-123 T 21-04-2016 SPH21_RS10045 8edea9b1188ebb5e7ff347ecbf2d30b4 461 TIGRFAM TIGR03023 WcaJ_sugtrans: undecaprenyl-phosphate glucose phosphotransferase 40 461 1.4E-131 T 21-04-2016 IPR017473 Undecaprenyl-phosphate glucose phosphotransferase, WcaJ MetaCyc: PWY-6655|MetaCyc: PWY-6658 SPH21_RS10045 8edea9b1188ebb5e7ff347ecbf2d30b4 461 Pfam PF13727 CoA-binding domain 62 233 5.8E-10 T 21-04-2016 SPH21_RS10045 8edea9b1188ebb5e7ff347ecbf2d30b4 461 TIGRFAM TIGR03025 EPS_sugtrans: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase 16 461 3.4E-121 T 21-04-2016 IPR017475 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase SPH21_RS10045 8edea9b1188ebb5e7ff347ecbf2d30b4 461 PANTHER PTHR30576:SF0 6 461 2.3E-123 T 21-04-2016 SPH21_RS02535 b41be8b9ae7842b73a0489ffa91c489a 460 SUPERFAMILY SSF53067 9 237 6.47E-20 T 21-04-2016 SPH21_RS02535 b41be8b9ae7842b73a0489ffa91c489a 460 Gene3D G3DSA:3.30.420.40 4 238 4.0E-16 T 21-04-2016 SPH21_RS02535 b41be8b9ae7842b73a0489ffa91c489a 460 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 6 196 1.9E-14 T 21-04-2016 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SPH21_RS02535 b41be8b9ae7842b73a0489ffa91c489a 460 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 386 432 1.2E-4 T 21-04-2016 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SPH21_RS02535 b41be8b9ae7842b73a0489ffa91c489a 460 PANTHER PTHR10196 4 257 4.8E-12 T 21-04-2016 SPH21_RS02535 b41be8b9ae7842b73a0489ffa91c489a 460 Gene3D G3DSA:3.30.420.40 386 432 3.7E-4 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 SUPERFAMILY SSF56935 1000 1044 1.37E-83 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 SUPERFAMILY SSF56935 1090 1184 1.37E-83 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 SUPERFAMILY SSF56935 566 916 1.37E-83 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 SUPERFAMILY SSF56935 445 535 1.37E-83 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 SUPERFAMILY SSF56935 233 373 1.37E-83 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Gene3D G3DSA:2.60.40.1120 157 245 1.8E-8 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Gene3D G3DSA:2.40.170.20 454 531 4.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Gene3D G3DSA:2.40.170.20 1009 1051 4.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Gene3D G3DSA:2.40.170.20 354 371 4.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Gene3D G3DSA:2.40.170.20 563 928 4.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Gene3D G3DSA:2.40.170.20 1097 1184 4.1E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 SMART SM00965 99 150 3.6E-7 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Pfam PF07660 Secretin and TonB N terminus short domain 99 150 1.1E-11 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 157 1184 8.9E-265 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Pfam PF07715 TonB-dependent Receptor Plug Domain 246 349 1.8E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 325 355 3.9E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 PANTHER PTHR11532 619 1182 1.4E-255 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 PANTHER PTHR11532 123 501 1.4E-255 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 SUPERFAMILY SSF49464 157 235 5.36E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Pfam PF13715 CarboxypepD_reg-like domain 157 237 1.6E-12 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 PANTHER PTHR11532:SF57 619 1182 1.4E-255 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 PANTHER PTHR11532:SF57 123 501 1.4E-255 T 21-04-2016 SPH21_RS04135 89494fe3303058ff780adba7df175f8d 1184 Gene3D G3DSA:2.170.130.10 246 353 3.3E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS00785 759a839bbe1ce17f1b4c35708e112ab2 86 Pfam PF14294 Domain of unknown function (DUF4372) 9 78 9.6E-24 T 21-04-2016 IPR025399 Domain of unknown function DUF4372 SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 PIRSF PIRSF001084 12 674 7.6E-135 T 21-04-2016 IPR003476 Glycoside hydrolase, family 42 GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 Gene3D G3DSA:3.40.50.880 401 608 1.2E-34 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 Pfam PF08532 Beta-galactosidase trimerisation domain 403 605 6.5E-39 T 21-04-2016 IPR013738 Beta-galactosidase trimerisation GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 Pfam PF02449 Beta-galactosidase 25 391 1.3E-81 T 21-04-2016 IPR013529 Glycoside hydrolase, family 42, N-terminal GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 SUPERFAMILY SSF51445 20 389 3.68E-72 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 PANTHER PTHR36447:SF1 19 674 6.6E-126 T 21-04-2016 SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 PANTHER PTHR36447 19 674 6.6E-126 T 21-04-2016 SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 Gene3D G3DSA:3.20.20.80 21 392 5.3E-90 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS13130 a369ab739129186d2ba3490d76b1e8c6 674 SUPERFAMILY SSF52317 401 605 2.75E-38 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS19035 bc682e110db655d24f328181e620815a 664 SUPERFAMILY SSF53756 37 421 8.24E-85 T 21-04-2016 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 Pfam PF13439 Glycosyltransferase Family 4 39 216 2.6E-29 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS19035 bc682e110db655d24f328181e620815a 664 PANTHER PTHR30390 431 642 5.3E-76 T 21-04-2016 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 Pfam PF13580 SIS domain 442 573 5.6E-25 T 21-04-2016 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 Reactome: REACT_17015 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 Pfam PF00534 Glycosyl transferases group 1 232 387 6.9E-41 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 PANTHER PTHR30390:SF6 431 642 5.3E-76 T 21-04-2016 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 SUPERFAMILY SSF53697 432 618 1.69E-45 T 21-04-2016 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 Hamap MF_00067 Phosphoheptose isomerase [gmhA]. 425 617 34.71 T 21-04-2016 IPR004515 Phosphoheptose isomerase GO:0005737|GO:0008968 KEGG: 00540+5.3.1.28|MetaCyc: PWY-6478|UniPathway: UPA00041 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 Gene3D G3DSA:3.40.50.10490 433 618 5.6E-53 T 21-04-2016 SPH21_RS19035 bc682e110db655d24f328181e620815a 664 Gene3D G3DSA:3.40.50.2000 197 385 5.1E-40 T 21-04-2016 SPH21_RS26245 1405aa3a9321a43c11e433e603d67696 327 PANTHER PTHR30273:SF2 44 327 3.5E-48 T 21-04-2016 SPH21_RS26245 1405aa3a9321a43c11e433e603d67696 327 PANTHER PTHR30273 44 327 3.5E-48 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26245 1405aa3a9321a43c11e433e603d67696 327 Pfam PF16344 Domain of unknown function (DUF4974) 230 324 1.1E-13 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS26245 1405aa3a9321a43c11e433e603d67696 327 Pfam PF04773 FecR protein 117 213 2.1E-21 T 21-04-2016 IPR006860 FecR protein SPH21_RS26245 1405aa3a9321a43c11e433e603d67696 327 PIRSF PIRSF018266 1 327 2.6E-49 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS17980 6b745d0564125ac3a5f05bf8b421f496 282 Pfam PF09357 RteC protein 62 280 8.2E-77 T 21-04-2016 IPR018534 Tetracycline regulation of excision, RteC SPH21_RS21485 07445a17a3bd65bba4cf74b500deedab 294 Pfam PF13460 NAD(P)H-binding 7 190 8.0E-15 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21485 07445a17a3bd65bba4cf74b500deedab 294 Gene3D G3DSA:3.40.50.720 1 204 2.8E-29 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21485 07445a17a3bd65bba4cf74b500deedab 294 SUPERFAMILY SSF51735 1 256 2.27E-35 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21485 07445a17a3bd65bba4cf74b500deedab 294 Gene3D G3DSA:3.50.50.60 233 280 4.2E-4 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21485 07445a17a3bd65bba4cf74b500deedab 294 PANTHER PTHR14194 1 291 1.7E-28 T 21-04-2016 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 Gene3D G3DSA:1.10.2020.10 46 135 2.6E-38 T 21-04-2016 IPR023177 Uronate isomerase, domain 2 GO:0008880 KEGG: 00040+5.3.1.12|MetaCyc: PWY-7247|MetaCyc: PWY-7248|UniPathway: UPA00246 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 Hamap MF_00675 Uronate isomerase [uxaC]. 2 467 45.303 T 21-04-2016 IPR003766 Uronate isomerase GO:0006064|GO:0008880 KEGG: 00040+5.3.1.12|MetaCyc: PWY-7247|MetaCyc: PWY-7248|UniPathway: UPA00246 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 Gene3D G3DSA:3.20.20.140 138 466 4.7E-139 T 21-04-2016 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 Gene3D G3DSA:3.20.20.140 4 44 4.7E-139 T 21-04-2016 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 PANTHER PTHR30068 2 467 2.7E-217 T 21-04-2016 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 Pfam PF02614 Glucuronate isomerase 1 465 2.8E-197 T 21-04-2016 IPR003766 Uronate isomerase GO:0006064|GO:0008880 KEGG: 00040+5.3.1.12|MetaCyc: PWY-7247|MetaCyc: PWY-7248|UniPathway: UPA00246 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 PANTHER PTHR30068:SF4 2 467 2.7E-217 T 21-04-2016 SPH21_RS02860 84b0e3e2150327910877ec9ec40d9567 467 SUPERFAMILY SSF51556 2 465 5.1E-164 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS17855 09ca80bd471919152b28a133d438ad61 265 PANTHER PTHR30269:SF14 1 264 2.4E-39 T 21-04-2016 SPH21_RS17855 09ca80bd471919152b28a133d438ad61 265 Pfam PF01925 Sulfite exporter TauE/SafE 8 257 5.5E-49 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS17855 09ca80bd471919152b28a133d438ad61 265 PANTHER PTHR30269 1 264 2.4E-39 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS06290 762bf593a2d3fa9b2b7e056a18d1e20b 402 PANTHER PTHR30273 189 383 2.4E-59 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS06290 762bf593a2d3fa9b2b7e056a18d1e20b 402 PANTHER PTHR30273 10 126 2.4E-59 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS06290 762bf593a2d3fa9b2b7e056a18d1e20b 402 PANTHER PTHR30273:SF2 189 383 2.4E-59 T 21-04-2016 SPH21_RS06290 762bf593a2d3fa9b2b7e056a18d1e20b 402 PANTHER PTHR30273:SF2 10 126 2.4E-59 T 21-04-2016 SPH21_RS06290 762bf593a2d3fa9b2b7e056a18d1e20b 402 Pfam PF04773 FecR protein 187 281 2.7E-19 T 21-04-2016 IPR006860 FecR protein SPH21_RS06290 762bf593a2d3fa9b2b7e056a18d1e20b 402 Pfam PF16344 Domain of unknown function (DUF4974) 300 393 1.3E-21 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS23355 99134191ce02d38245fffd5653c2c2cc 119 Gene3D G3DSA:3.40.50.2300 2 118 1.3E-25 T 21-04-2016 SPH21_RS23355 99134191ce02d38245fffd5653c2c2cc 119 SUPERFAMILY SSF52172 2 118 8.54E-29 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS23355 99134191ce02d38245fffd5653c2c2cc 119 SMART SM00448 4 114 1.0E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS23355 99134191ce02d38245fffd5653c2c2cc 119 PANTHER PTHR26402 4 116 1.8E-24 T 21-04-2016 SPH21_RS23355 99134191ce02d38245fffd5653c2c2cc 119 Pfam PF00072 Response regulator receiver domain 6 115 1.5E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS09860 f29919c69d58771f8c7f4af7861590ae 764 Gene3D G3DSA:3.40.50.720 20 168 3.8E-23 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09860 f29919c69d58771f8c7f4af7861590ae 764 Pfam PF12831 FAD dependent oxidoreductase 22 435 2.1E-96 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS09860 f29919c69d58771f8c7f4af7861590ae 764 SUPERFAMILY SSF51905 215 254 3.45E-20 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS09860 f29919c69d58771f8c7f4af7861590ae 764 SUPERFAMILY SSF51905 361 409 3.45E-20 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS09860 f29919c69d58771f8c7f4af7861590ae 764 SUPERFAMILY SSF51905 20 174 3.45E-20 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS10675 2c5a10caf3033c88566a98188bdba0be 204 SMART SM00421 142 199 6.9E-4 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10675 2c5a10caf3033c88566a98188bdba0be 204 SUPERFAMILY SSF46894 133 200 2.86E-9 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS10675 2c5a10caf3033c88566a98188bdba0be 204 Pfam PF00196 Bacterial regulatory proteins, luxR family 144 196 2.6E-6 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10675 2c5a10caf3033c88566a98188bdba0be 204 Gene3D G3DSA:1.10.10.10 107 200 4.4E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10675 2c5a10caf3033c88566a98188bdba0be 204 SUPERFAMILY SSF52172 1 112 5.27E-7 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS20080 6b502d2b8557c779f7dab588509339de 344 SUPERFAMILY SSF55874 208 329 2.18E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20080 6b502d2b8557c779f7dab588509339de 344 Gene3D G3DSA:3.30.565.10 203 320 0.001 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS20080 6b502d2b8557c779f7dab588509339de 344 PANTHER PTHR34220 13 344 1.3E-56 T 21-04-2016 SPH21_RS20080 6b502d2b8557c779f7dab588509339de 344 Pfam PF06580 Histidine kinase 154 232 9.8E-25 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS18705 bd015981a9a1df9aa238d9f99214d3d6 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 3.2E-10 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS18705 bd015981a9a1df9aa238d9f99214d3d6 208 PANTHER PTHR30328 4 163 1.0E-12 T 21-04-2016 SPH21_RS18705 bd015981a9a1df9aa238d9f99214d3d6 208 ProSitePatterns PS01081 TetR-type HTH domain signature. 23 54 - T 21-04-2016 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SPH21_RS18705 bd015981a9a1df9aa238d9f99214d3d6 208 SUPERFAMILY SSF46689 5 75 4.82E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18705 bd015981a9a1df9aa238d9f99214d3d6 208 Gene3D G3DSA:1.10.357.10 7 200 2.4E-22 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS03605 4eb8201ea73711f35c225743886e2250 397 Pfam PF07470 Glycosyl Hydrolase Family 88 67 391 9.3E-22 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS03605 4eb8201ea73711f35c225743886e2250 397 Gene3D G3DSA:1.50.10.10 32 395 6.4E-139 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS03605 4eb8201ea73711f35c225743886e2250 397 SUPERFAMILY SSF48208 35 396 1.16E-98 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS03605 4eb8201ea73711f35c225743886e2250 397 PANTHER PTHR36845:SF1 1 396 2.3E-92 T 21-04-2016 SPH21_RS03605 4eb8201ea73711f35c225743886e2250 397 PANTHER PTHR36845 1 396 2.3E-92 T 21-04-2016 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 SUPERFAMILY SSF48208 654 830 3.06E-25 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 SUPERFAMILY SSF48208 480 626 3.06E-25 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 Pfam PF04685 Glycosyl-hydrolase family 116, catalytic region 504 807 5.1E-64 T 21-04-2016 IPR006775 Glycosyl-hydrolase family 116, catalytic region GO:0004553 KEGG: 00511+3.2.1.45|KEGG: 00600+3.2.1.45 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 PANTHER PTHR12654:SF0 367 624 1.1E-104 T 21-04-2016 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 PANTHER PTHR12654:SF0 662 868 1.1E-104 T 21-04-2016 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 PANTHER PTHR12654:SF0 68 341 1.1E-104 T 21-04-2016 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 Pfam PF12215 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term 69 393 9.6E-46 T 21-04-2016 IPR024462 Glycosyl-hydrolase family 116, N-terminal KEGG: 00511+3.2.1.45|KEGG: 00600+3.2.1.45 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 PANTHER PTHR12654 367 624 1.1E-104 T 21-04-2016 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 PANTHER PTHR12654 662 868 1.1E-104 T 21-04-2016 SPH21_RS03030 d157371cdde154e62ece246fb07a9521 877 PANTHER PTHR12654 68 341 1.1E-104 T 21-04-2016 SPH21_RS20330 5c16114c51d75941682bdeb019dac6bb 390 Gene3D G3DSA:2.40.50.100 65 98 2.2E-8 T 21-04-2016 SPH21_RS20330 5c16114c51d75941682bdeb019dac6bb 390 Gene3D G3DSA:2.40.50.100 238 272 2.2E-8 T 21-04-2016 SPH21_RS20330 5c16114c51d75941682bdeb019dac6bb 390 PANTHER PTHR30386:SF8 33 387 1.6E-30 T 21-04-2016 SPH21_RS20330 5c16114c51d75941682bdeb019dac6bb 390 PANTHER PTHR30386 33 387 1.6E-30 T 21-04-2016 SPH21_RS20330 5c16114c51d75941682bdeb019dac6bb 390 Pfam PF13437 HlyD family secretion protein 240 348 1.6E-15 T 21-04-2016 SPH21_RS08930 2e608f0ea1b0000bf1c97540717bd1f4 358 Pfam PF09314 Domain of unknown function (DUF1972) 3 175 6.3E-21 T 21-04-2016 IPR015393 Domain of unknown function DUF1972 SPH21_RS08930 2e608f0ea1b0000bf1c97540717bd1f4 358 SUPERFAMILY SSF53756 1 358 3.06E-27 T 21-04-2016 SPH21_RS09890 0223943d1cf8e830563d8c859e8bb8e0 364 Gene3D G3DSA:3.90.550.10 3 275 6.7E-81 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09890 0223943d1cf8e830563d8c859e8bb8e0 364 SUPERFAMILY SSF159283 288 353 1.83E-10 T 21-04-2016 SPH21_RS09890 0223943d1cf8e830563d8c859e8bb8e0 364 SUPERFAMILY SSF53448 5 283 6.76E-66 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09890 0223943d1cf8e830563d8c859e8bb8e0 364 PANTHER PTHR12526:SF387 156 293 1.2E-37 T 21-04-2016 SPH21_RS09890 0223943d1cf8e830563d8c859e8bb8e0 364 PANTHER PTHR12526 156 293 1.2E-37 T 21-04-2016 SPH21_RS09890 0223943d1cf8e830563d8c859e8bb8e0 364 Pfam PF00483 Nucleotidyl transferase 8 290 9.2E-45 T 21-04-2016 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 Reactome: REACT_17015 SPH21_RS02635 8a2533c28838fdf420b720c934ae9346 1192 Pfam PF00149 Calcineurin-like phosphoesterase 16 213 2.5E-8 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS02635 8a2533c28838fdf420b720c934ae9346 1192 SUPERFAMILY SSF56300 18 216 4.22E-31 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS02635 8a2533c28838fdf420b720c934ae9346 1192 SUPERFAMILY SSF56300 264 338 4.22E-31 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS02635 8a2533c28838fdf420b720c934ae9346 1192 Gene3D G3DSA:3.60.21.10 18 216 1.8E-34 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS02635 8a2533c28838fdf420b720c934ae9346 1192 Gene3D G3DSA:3.60.21.10 264 349 1.8E-34 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS03095 b1ed2a881cd04b1070df1a4b45f3f5b1 552 Pfam PF04295 D-galactarate dehydratase / Altronate hydrolase, C terminus 112 550 1.1E-152 T 21-04-2016 IPR007392 D-galactarate/Altronate dehydratase, C-terminal GO:0016829 SPH21_RS03095 b1ed2a881cd04b1070df1a4b45f3f5b1 552 SMART SM00858 14 85 1.6E-9 T 21-04-2016 IPR013974 SAF domain SPH21_RS03095 b1ed2a881cd04b1070df1a4b45f3f5b1 552 Pfam PF08666 SAF domain 14 84 2.3E-5 T 21-04-2016 IPR013974 SAF domain SPH21_RS03095 b1ed2a881cd04b1070df1a4b45f3f5b1 552 PANTHER PTHR30536 191 552 4.7E-136 T 21-04-2016 SPH21_RS03095 b1ed2a881cd04b1070df1a4b45f3f5b1 552 PANTHER PTHR30536 1 153 4.7E-136 T 21-04-2016 SPH21_RS03095 b1ed2a881cd04b1070df1a4b45f3f5b1 552 PANTHER PTHR30536:SF5 191 552 4.7E-136 T 21-04-2016 SPH21_RS03095 b1ed2a881cd04b1070df1a4b45f3f5b1 552 PANTHER PTHR30536:SF5 1 153 4.7E-136 T 21-04-2016 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 39 163 1.8E-15 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 Gene3D G3DSA:3.40.50.720 35 177 8.3E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 PANTHER PTHR22604:SF122 1 432 4.8E-121 T 21-04-2016 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 Gene3D G3DSA:3.30.360.10 178 334 7.6E-28 T 21-04-2016 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 Gene3D G3DSA:3.30.360.10 369 421 7.6E-28 T 21-04-2016 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 234 263 0.0015 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 SUPERFAMILY SSF55347 178 337 7.85E-24 T 21-04-2016 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 PANTHER PTHR22604 1 432 4.8E-121 T 21-04-2016 SPH21_RS02770 3b85d5203c212876b843a49722d3e11f 452 SUPERFAMILY SSF51735 34 197 1.73E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 6 26 8.8E-5 T 21-04-2016 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 SUPERFAMILY SSF51735 33 194 3.8E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 Gene3D G3DSA:3.40.50.720 35 186 2.8E-37 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 PANTHER PTHR22604 1 200 2.2E-68 T 21-04-2016 SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 PANTHER PTHR22604 221 406 2.2E-68 T 21-04-2016 SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 Gene3D G3DSA:3.30.360.10 187 397 2.6E-10 T 21-04-2016 SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 45 156 1.3E-18 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 PANTHER PTHR22604:SF122 1 200 2.2E-68 T 21-04-2016 SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 PANTHER PTHR22604:SF122 221 406 2.2E-68 T 21-04-2016 SPH21_RS14695 2c19be1b97b2ac798e3a52c1c7c616ce 423 SUPERFAMILY SSF55347 174 309 1.16E-11 T 21-04-2016 SPH21_RS04980 b28862dad897d0237be80cbb5e8dac59 487 SUPERFAMILY SSF48452 20 478 1.64E-82 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04980 b28862dad897d0237be80cbb5e8dac59 487 Pfam PF14322 Starch-binding associating with outer membrane 74 240 9.9E-28 T 21-04-2016 SPH21_RS04980 b28862dad897d0237be80cbb5e8dac59 487 Pfam PF07980 SusD family 338 477 4.0E-17 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04980 b28862dad897d0237be80cbb5e8dac59 487 Gene3D G3DSA:1.25.40.10 225 421 3.2E-22 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13490 3c4788799ca43d9736ad074f19fc6fee 148 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 2 86 1.5E-12 T 21-04-2016 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|UniPathway: UPA00647 SPH21_RS13490 3c4788799ca43d9736ad074f19fc6fee 148 SUPERFAMILY SSF50475 1 89 1.64E-16 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS13490 3c4788799ca43d9736ad074f19fc6fee 148 Gene3D G3DSA:2.30.110.10 1 118 4.3E-24 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS17740 2195ff1fbdd90da184d7cc28b1f413ef 148 Pfam PF12988 Domain of unknown function, B. Theta Gene description (DUF3872) 15 146 2.0E-58 T 21-04-2016 IPR024355 Protein of unknown function DUF3872 SPH21_RS09610 4ab7b37e35cae4dd56643fbcdb167be6 394 SUPERFAMILY SSF53448 4 227 1.01E-17 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09610 4ab7b37e35cae4dd56643fbcdb167be6 394 Gene3D G3DSA:3.90.550.10 4 228 1.9E-8 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09610 4ab7b37e35cae4dd56643fbcdb167be6 394 PANTHER PTHR33604 1 272 1.2E-27 T 21-04-2016 SPH21_RS09610 4ab7b37e35cae4dd56643fbcdb167be6 394 Pfam PF00535 Glycosyl transferase family 2 5 151 4.3E-6 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS03935 8023d6cc99ed489bb86d64d6d63ba41b 282 PANTHER PTHR12121 17 282 2.6E-78 T 21-04-2016 SPH21_RS03935 8023d6cc99ed489bb86d64d6d63ba41b 282 PANTHER PTHR12121:SF36 17 282 2.6E-78 T 21-04-2016 SPH21_RS03935 8023d6cc99ed489bb86d64d6d63ba41b 282 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 27 272 1.2E-14 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS03935 8023d6cc99ed489bb86d64d6d63ba41b 282 SUPERFAMILY SSF56219 17 282 1.2E-37 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS03935 8023d6cc99ed489bb86d64d6d63ba41b 282 Gene3D G3DSA:3.60.10.10 24 279 1.2E-19 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 Gene3D G3DSA:3.40.630.10 30 86 3.5E-52 T 21-04-2016 SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 Gene3D G3DSA:3.40.630.10 211 427 3.5E-52 T 21-04-2016 SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 PANTHER PTHR12147 34 420 3.1E-40 T 21-04-2016 SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 Gene3D G3DSA:3.40.920.10 150 203 1.1E-4 T 21-04-2016 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 Pfam PF04389 Peptidase family M28 219 417 4.5E-37 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 PANTHER PTHR12147:SF16 34 420 3.1E-40 T 21-04-2016 SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 SUPERFAMILY SSF53187 203 419 7.1E-54 T 21-04-2016 SPH21_RS05665 a237a7bb1d59b4417de8c4f5dea4446c 441 SUPERFAMILY SSF53187 33 79 7.1E-54 T 21-04-2016 SPH21_RS01390 fc82b2c2fe22b595788614891d672fdf 402 Gene3D G3DSA:2.40.50.100 117 148 7.2E-12 T 21-04-2016 SPH21_RS01390 fc82b2c2fe22b595788614891d672fdf 402 Gene3D G3DSA:2.40.50.100 207 238 7.2E-12 T 21-04-2016 SPH21_RS01390 fc82b2c2fe22b595788614891d672fdf 402 SUPERFAMILY SSF111369 112 317 1.15E-16 T 21-04-2016 SPH21_RS01390 fc82b2c2fe22b595788614891d672fdf 402 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 103 313 3.1E-51 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS01390 fc82b2c2fe22b595788614891d672fdf 402 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 88 384 9.7E-43 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS01390 fc82b2c2fe22b595788614891d672fdf 402 PANTHER PTHR30097:SF3 38 393 6.3E-70 T 21-04-2016 SPH21_RS01390 fc82b2c2fe22b595788614891d672fdf 402 PANTHER PTHR30097 38 393 6.3E-70 T 21-04-2016 SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 SUPERFAMILY SSF52172 2 123 2.42E-23 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 Pfam PF04397 LytTr DNA-binding domain 139 222 1.8E-19 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 SMART SM00850 136 222 5.4E-20 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 Gene3D G3DSA:3.40.50.2300 1 116 8.7E-22 T 21-04-2016 SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 SMART SM00448 2 110 1.5E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 Pfam PF00072 Response regulator receiver domain 6 109 2.4E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 Gene3D G3DSA:2.40.50.40 128 195 2.7E-22 T 21-04-2016 SPH21_RS22205 8e5afd89ad286761a5139f236095cb56 225 PANTHER PTHR26402 2 109 1.0E-20 T 21-04-2016 SPH21_RS12700 e42476deff2746c838b2248ba728b91e 267 Pfam PF10677 Protein of unknown function (DUF2490) 84 237 1.3E-12 T 21-04-2016 IPR019619 Protein of unknown function DUF2490 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 PANTHER PTHR11532:SF57 1 304 1.6E-198 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 PANTHER PTHR11532:SF57 486 1041 1.6E-198 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 PANTHER PTHR11532:SF57 323 382 1.6E-198 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Pfam PF07715 TonB-dependent Receptor Plug Domain 98 205 1.2E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Pfam PF13715 CarboxypepD_reg-like domain 9 90 3.1E-13 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 SUPERFAMILY SSF56935 864 909 1.33E-88 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 SUPERFAMILY SSF56935 950 1043 1.33E-88 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 SUPERFAMILY SSF56935 86 229 1.33E-88 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 SUPERFAMILY SSF56935 327 416 1.33E-88 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 SUPERFAMILY SSF56935 459 795 1.33E-88 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 SUPERFAMILY SSF49464 8 88 7.46E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 181 211 1.6E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Gene3D G3DSA:2.170.130.10 94 205 9.6E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Gene3D G3DSA:2.40.170.20 206 229 2.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Gene3D G3DSA:2.40.170.20 336 805 2.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Gene3D G3DSA:2.40.170.20 874 899 2.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Gene3D G3DSA:2.40.170.20 939 1043 2.5E-45 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 8 1043 2.2E-233 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 PANTHER PTHR11532 1 304 1.6E-198 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 PANTHER PTHR11532 486 1041 1.6E-198 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 PANTHER PTHR11532 323 382 1.6E-198 T 21-04-2016 SPH21_RS04985 44689eab26ced295851f2066370c06a9 1043 Gene3D G3DSA:2.60.40.1120 9 93 1.3E-8 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS07610 238e035bfa60a577f6b15ee967679f86 516 PANTHER PTHR26402 4 138 4.6E-26 T 21-04-2016 SPH21_RS07610 238e035bfa60a577f6b15ee967679f86 516 SUPERFAMILY SSF53649 226 515 1.83E-6 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS07610 238e035bfa60a577f6b15ee967679f86 516 Pfam PF08665 PglZ domain 230 421 8.8E-30 T 21-04-2016 IPR013973 PglZ domain SPH21_RS07610 238e035bfa60a577f6b15ee967679f86 516 Pfam PF00072 Response regulator receiver domain 6 114 1.3E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS07610 238e035bfa60a577f6b15ee967679f86 516 SUPERFAMILY SSF52172 1 141 9.82E-31 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS07610 238e035bfa60a577f6b15ee967679f86 516 Gene3D G3DSA:3.40.50.2300 2 127 5.8E-29 T 21-04-2016 SPH21_RS07610 238e035bfa60a577f6b15ee967679f86 516 SMART SM00448 4 115 2.6E-21 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 SMART SM00965 64 115 6.6E-5 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 PANTHER PTHR11532:SF57 604 1109 5.1E-227 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 PANTHER PTHR11532:SF57 503 548 5.1E-227 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 PANTHER PTHR11532:SF57 131 463 5.1E-227 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Pfam PF13715 CarboxypepD_reg-like domain 130 209 5.8E-18 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 SUPERFAMILY SSF49464 128 205 2.49E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Gene3D G3DSA:2.60.40.1120 129 211 1.8E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 301 330 3.0E-17 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 SUPERFAMILY SSF56935 409 497 4.4E-93 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 SUPERFAMILY SSF56935 937 980 4.4E-93 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 SUPERFAMILY SSF56935 532 873 4.4E-93 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 SUPERFAMILY SSF56935 1019 1111 4.4E-93 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 SUPERFAMILY SSF56935 205 348 4.4E-93 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Pfam PF07715 TonB-dependent Receptor Plug Domain 219 324 3.6E-17 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Pfam PF07660 Secretin and TonB N terminus short domain 64 115 3.7E-10 T 21-04-2016 IPR011662 Secretin/TonB, short N-terminal domain GO:0019867 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 129 1111 1.7E-250 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Gene3D G3DSA:2.170.130.10 212 325 1.4E-16 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 PANTHER PTHR11532 604 1109 5.1E-227 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 PANTHER PTHR11532 503 548 5.1E-227 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 PANTHER PTHR11532 131 463 5.1E-227 T 21-04-2016 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Gene3D G3DSA:2.40.170.20 945 970 3.6E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Gene3D G3DSA:2.40.170.20 418 880 3.6E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Gene3D G3DSA:2.40.170.20 1009 1111 3.6E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21330 9e0d2d3809b0385fa31f775e22bc2dde 1111 Gene3D G3DSA:2.40.170.20 326 344 3.6E-56 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24850 4924f7b992904ee02856d412dd8a648e 128 SUPERFAMILY SSF54593 11 122 1.32E-20 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS24850 4924f7b992904ee02856d412dd8a648e 128 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 12 117 3.5E-7 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS24850 4924f7b992904ee02856d412dd8a648e 128 Gene3D G3DSA:3.10.180.10 11 121 2.0E-18 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS20205 ae658cea6b5476123192b3c624101140 294 TIGRFAM TIGR01200 GLPGLI: GLPGLI family protein 11 237 1.8E-49 T 21-04-2016 IPR005901 GLPGLI family protein SPH21_RS20205 ae658cea6b5476123192b3c624101140 294 Pfam PF09697 Protein of unknown function (Porph_ging) 166 191 6.3E-6 T 21-04-2016 IPR005901 GLPGLI family protein SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 Gene3D G3DSA:1.10.150.210 18 75 6.4E-11 T 21-04-2016 IPR023190 Phosphoserine phosphatase, domain 2 GO:0004647|GO:0006564 KEGG: 00260+3.1.3.3|KEGG: 00680+3.1.3.3|UniPathway: UPA00135 SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 Gene3D G3DSA:3.30.70.260 347 429 1.5E-23 T 21-04-2016 SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 PANTHER PTHR10000 6 227 2.6E-28 T 21-04-2016 SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 SUPERFAMILY SSF55021 353 429 1.35E-16 T 21-04-2016 SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 SUPERFAMILY SSF56784 6 216 4.76E-31 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 SUPERFAMILY SSF52283 228 321 1.08E-6 T 21-04-2016 SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 5 179 2.8E-17 T 21-04-2016 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 PANTHER PTHR10000:SF7 6 227 2.6E-28 T 21-04-2016 SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 Gene3D G3DSA:3.40.50.1000 3 17 4.5E-12 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 Gene3D G3DSA:3.40.50.1000 80 214 4.5E-12 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS03660 1374ac7004261c089a87c067d1dbdd48 430 Gene3D G3DSA:3.40.50.720 229 316 6.9E-6 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 166 281 5.9E-21 T 21-04-2016 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 PIRSF PIRSF000103 1 287 1.7E-85 T 21-04-2016 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 SUPERFAMILY SSF51735 4 164 8.3E-46 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 Gene3D G3DSA:3.40.50.720 2 163 1.9E-53 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 Gene3D G3DSA:1.10.1040.10 165 285 3.7E-28 T 21-04-2016 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 PANTHER PTHR22981 5 286 5.9E-98 T 21-04-2016 SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 SUPERFAMILY SSF48179 165 284 8.05E-27 T 21-04-2016 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SPH21_RS05855 44d20d7b694dc3cb0475a9fca96eb336 288 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 4 163 6.9E-46 T 21-04-2016 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 Pfam PF12833 Helix-turn-helix domain 200 277 1.3E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 SUPERFAMILY SSF46689 231 278 8.6E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 SUPERFAMILY SSF46689 183 228 2.51E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 261 277 1.6E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 246 261 1.6E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 Gene3D G3DSA:1.10.10.60 185 231 3.5E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 SMART SM00342 194 277 1.5E-26 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 Gene3D G3DSA:1.10.10.60 232 278 4.4E-17 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04315 52ea76d4a761eeba4a063cdb3bcf2d03 283 PANTHER PTHR11019 183 283 2.5E-24 T 21-04-2016 SPH21_RS12960 65ce9c1f80fddd51268b5d8221628cf1 186 PANTHER PTHR30543:SF1 1 182 1.8E-33 T 21-04-2016 SPH21_RS12960 65ce9c1f80fddd51268b5d8221628cf1 186 SUPERFAMILY SSF52218 3 179 3.02E-36 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS12960 65ce9c1f80fddd51268b5d8221628cf1 186 Pfam PF03358 NADPH-dependent FMN reductase 3 146 6.1E-30 T 21-04-2016 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SPH21_RS12960 65ce9c1f80fddd51268b5d8221628cf1 186 PANTHER PTHR30543 1 182 1.8E-33 T 21-04-2016 SPH21_RS12960 65ce9c1f80fddd51268b5d8221628cf1 186 Gene3D G3DSA:3.40.50.360 1 183 9.5E-41 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS25560 011a85a95056ee34794979649e8dbf7e 170 Gene3D G3DSA:1.25.40.10 51 155 2.2E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 50 1086 2.0E-280 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 PANTHER PTHR11532:SF57 566 1084 7.6E-281 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 PANTHER PTHR11532:SF57 47 469 7.6E-281 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 Gene3D G3DSA:2.40.170.20 362 718 2.1E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 Gene3D G3DSA:2.40.170.20 754 864 2.1E-26 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 Pfam PF07715 TonB-dependent Receptor Plug Domain 141 248 7.4E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 Gene3D G3DSA:2.60.40.1120 51 141 1.7E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF49464 50 131 2.09E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 Gene3D G3DSA:2.170.130.10 142 257 5.3E-23 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF56935 465 517 5.49E-86 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF56935 547 711 5.49E-86 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF56935 363 434 5.49E-86 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF56935 751 853 5.49E-86 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF56935 921 967 5.49E-86 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF56935 131 276 5.49E-86 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 SUPERFAMILY SSF56935 1003 1086 5.49E-86 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 225 254 1.9E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 Pfam PF13715 CarboxypepD_reg-like domain 51 133 3.4E-19 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 PANTHER PTHR11532 566 1084 7.6E-281 T 21-04-2016 SPH21_RS08150 4ba6eeb11b1f1aabff7550bb387ac347 1086 PANTHER PTHR11532 47 469 7.6E-281 T 21-04-2016 SPH21_RS03565 315423a8887b4fb88540e0acc3878373 214 Gene3D G3DSA:3.40.50.2020 6 211 7.6E-47 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS03565 315423a8887b4fb88540e0acc3878373 214 PANTHER PTHR10285:SF46 11 202 6.2E-43 T 21-04-2016 SPH21_RS03565 315423a8887b4fb88540e0acc3878373 214 PANTHER PTHR10285 11 202 6.2E-43 T 21-04-2016 SPH21_RS03565 315423a8887b4fb88540e0acc3878373 214 SUPERFAMILY SSF53271 8 211 3.8E-44 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS03565 315423a8887b4fb88540e0acc3878373 214 Pfam PF14681 Uracil phosphoribosyltransferase 9 211 5.0E-38 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 Gene3D G3DSA:3.30.590.10 212 415 2.0E-83 T 21-04-2016 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 Reactome: REACT_13 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 Gene3D G3DSA:3.30.590.10 459 599 2.0E-83 T 21-04-2016 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 Reactome: REACT_13 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 ProSitePatterns PS00181 Glutamine synthetase putative ATP-binding region signature. 336 351 - T 21-04-2016 IPR027303 Glutamine synthetase, glycine-rich site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 SUPERFAMILY SSF55931 459 602 8.34E-70 T 21-04-2016 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 SUPERFAMILY SSF55931 182 415 8.34E-70 T 21-04-2016 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 PANTHER PTHR20852:SF14 207 419 2.3E-70 T 21-04-2016 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 SMART SM01230 192 477 6.1E-40 T 21-04-2016 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 Pfam PF12437 Glutamine synthetase type III N terminal 29 190 2.0E-72 T 21-04-2016 IPR022147 Glutamine synthetase type III N-terminal GO:0004356 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 PANTHER PTHR20852 207 419 2.3E-70 T 21-04-2016 SPH21_RS19780 231077d46a9b5879f55bf0f44af94444 729 Pfam PF00120 Glutamine synthetase, catalytic domain 207 368 4.2E-16 T 21-04-2016 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SPH21_RS17005 6fb1ba985016b1f36a00313ef6b5ff03 248 SUPERFAMILY SSF52540 4 232 6.99E-74 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17005 6fb1ba985016b1f36a00313ef6b5ff03 248 SMART SM00382 33 229 5.7E-12 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS17005 6fb1ba985016b1f36a00313ef6b5ff03 248 Pfam PF00005 ABC transporter 24 173 1.9E-32 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS17005 6fb1ba985016b1f36a00313ef6b5ff03 248 PANTHER PTHR24220 6 233 3.1E-120 T 21-04-2016 SPH21_RS17005 6fb1ba985016b1f36a00313ef6b5ff03 248 Gene3D G3DSA:3.40.50.300 3 226 9.8E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17005 6fb1ba985016b1f36a00313ef6b5ff03 248 ProSitePatterns PS00211 ABC transporters family signature. 146 160 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS17005 6fb1ba985016b1f36a00313ef6b5ff03 248 PANTHER PTHR24220:SF578 6 233 3.1E-120 T 21-04-2016 SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 Gene3D G3DSA:1.10.150.130 4 99 1.5E-21 T 21-04-2016 IPR023109 Integrase/recombinase, N-terminal SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 TIGRFAM TIGR02225 recomb_XerD: tyrosine recombinase XerD 9 298 4.1E-105 T 21-04-2016 IPR011932 Tyrosine recombinase XerD GO:0006310|GO:0009009 SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 Hamap MF_01808 Tyrosine recombinase XerC [xerC]. 3 298 30.002 T 21-04-2016 IPR023009 Tyrosine recombinase XerC/XerD SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 Pfam PF00589 Phage integrase family 117 283 7.1E-47 T 21-04-2016 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 PANTHER PTHR30349:SF5 4 298 3.5E-104 T 21-04-2016 SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 SUPERFAMILY SSF56349 4 291 1.71E-56 T 21-04-2016 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 PANTHER PTHR30349 4 298 3.5E-104 T 21-04-2016 SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 Pfam PF02899 Phage integrase, N-terminal SAM-like domain 7 90 3.7E-18 T 21-04-2016 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SPH21_RS12645 0b20ac7d283c015cdb01215aba2de8ec 298 Gene3D G3DSA:1.10.443.10 113 291 4.3E-55 T 21-04-2016 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS16865 1ab1a3142ffaa50a6049c5b4844b69cb 362 SUPERFAMILY SSF50969 84 334 5.65E-15 T 21-04-2016 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like SPH21_RS16865 1ab1a3142ffaa50a6049c5b4844b69cb 362 Gene3D G3DSA:2.130.10.10 84 355 1.5E-17 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS00960 c89ec838e4cab8f3372430f173d0e733 345 Pfam PF16344 Domain of unknown function (DUF4974) 226 328 2.1E-9 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS00960 c89ec838e4cab8f3372430f173d0e733 345 PANTHER PTHR30273:SF2 25 341 2.2E-31 T 21-04-2016 SPH21_RS00960 c89ec838e4cab8f3372430f173d0e733 345 Pfam PF04773 FecR protein 117 210 2.9E-11 T 21-04-2016 IPR006860 FecR protein SPH21_RS00960 c89ec838e4cab8f3372430f173d0e733 345 PANTHER PTHR30273 25 341 2.2E-31 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS02300 1bb0c3485a6e588fa996c2f58a470a89 102 Pfam PF05336 Domain of unknown function (DUF718) 2 101 9.2E-29 T 21-04-2016 IPR008000 Rhamnose/fucose mutarotase GO:0005737|GO:0016857 UniPathway: UPA00125 SPH21_RS02300 1bb0c3485a6e588fa996c2f58a470a89 102 SUPERFAMILY SSF54909 1 101 1.98E-34 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS02300 1bb0c3485a6e588fa996c2f58a470a89 102 PANTHER PTHR34389 4 102 1.7E-36 T 21-04-2016 SPH21_RS02300 1bb0c3485a6e588fa996c2f58a470a89 102 PANTHER PTHR34389:SF2 4 102 1.7E-36 T 21-04-2016 SPH21_RS02300 1bb0c3485a6e588fa996c2f58a470a89 102 TIGRFAM TIGR02625 YiiL_rotase: L-rhamnose mutarotase 3 102 2.1E-34 T 21-04-2016 IPR013448 L-rhamnose mutarotase GO:0005737|GO:0016857|GO:0019299 UniPathway: UPA00125 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Gene3D G3DSA:2.40.170.20 221 257 6.8E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Gene3D G3DSA:2.40.170.20 291 769 6.8E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Gene3D G3DSA:2.40.170.20 875 982 6.8E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Gene3D G3DSA:2.40.170.20 810 835 6.8E-57 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Gene3D G3DSA:2.170.130.10 108 220 7.2E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 24 982 1.4E-270 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532:SF57 378 419 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532:SF57 475 946 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532:SF57 5 336 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532:SF57 962 980 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 SUPERFAMILY SSF56935 882 982 1.05E-97 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 SUPERFAMILY SSF56935 801 845 1.05E-97 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 SUPERFAMILY SSF56935 99 243 1.05E-97 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 SUPERFAMILY SSF56935 282 370 1.05E-97 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 SUPERFAMILY SSF56935 403 741 1.05E-97 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 SUPERFAMILY SSF49464 23 103 1.24E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Gene3D G3DSA:2.60.40.1120 24 107 3.1E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532 378 419 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532 475 946 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532 5 336 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 PANTHER PTHR11532 962 980 4.3E-262 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Pfam PF13715 CarboxypepD_reg-like domain 25 105 5.3E-17 T 21-04-2016 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 195 225 1.6E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS11625 bfa43177e9357e004f2ffb6dca9fbb4a 982 Pfam PF07715 TonB-dependent Receptor Plug Domain 115 219 4.3E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12335 8f7cbdb894ec5ab66e99ad57852d0f89 139 Pfam PF13508 Acetyltransferase (GNAT) domain 51 126 6.1E-10 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS12335 8f7cbdb894ec5ab66e99ad57852d0f89 139 PANTHER PTHR13355:SF5 1 137 9.5E-19 T 21-04-2016 SPH21_RS12335 8f7cbdb894ec5ab66e99ad57852d0f89 139 PANTHER PTHR13355 1 137 9.5E-19 T 21-04-2016 SPH21_RS12335 8f7cbdb894ec5ab66e99ad57852d0f89 139 Gene3D G3DSA:3.40.630.30 18 132 4.8E-25 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12335 8f7cbdb894ec5ab66e99ad57852d0f89 139 SUPERFAMILY SSF55729 24 132 1.34E-20 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 Gene3D G3DSA:1.10.10.60 166 228 3.3E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 SUPERFAMILY SSF46689 228 276 4.12E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 Gene3D G3DSA:1.10.10.60 233 276 2.0E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 Gene3D G3DSA:2.60.120.280 21 159 3.6E-13 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 Pfam PF02311 AraC-like ligand binding domain 23 71 4.7E-9 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 SUPERFAMILY SSF51215 20 99 1.31E-13 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 SMART SM00342 191 274 1.8E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 PANTHER PTHR11019 20 275 1.8E-27 T 21-04-2016 SPH21_RS24170 e4e2c7d0e6e81d9e60985a748e1f9681 276 Pfam PF12833 Helix-turn-helix domain 198 275 3.9E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS19575 562b35b878493561688c3bd63448df8a 305 Pfam PF00892 EamA-like transporter family 5 138 5.7E-14 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS19575 562b35b878493561688c3bd63448df8a 305 Pfam PF00892 EamA-like transporter family 152 286 4.9E-10 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS19575 562b35b878493561688c3bd63448df8a 305 PANTHER PTHR22911:SF68 1 282 7.9E-40 T 21-04-2016 SPH21_RS19575 562b35b878493561688c3bd63448df8a 305 PANTHER PTHR22911 1 282 7.9E-40 T 21-04-2016 SPH21_RS19575 562b35b878493561688c3bd63448df8a 305 SUPERFAMILY SSF103481 44 138 3.66E-8 T 21-04-2016 SPH21_RS19575 562b35b878493561688c3bd63448df8a 305 SUPERFAMILY SSF103481 211 289 3.27E-8 T 21-04-2016 SPH21_RS12365 8058d6558a9b01c92b638c6f9b104ea9 586 Gene3D G3DSA:1.25.40.10 202 321 1.1E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12365 8058d6558a9b01c92b638c6f9b104ea9 586 Gene3D G3DSA:1.25.40.10 403 495 1.1E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12365 8058d6558a9b01c92b638c6f9b104ea9 586 Pfam PF14322 Starch-binding associating with outer membrane 80 220 1.5E-15 T 21-04-2016 SPH21_RS12365 8058d6558a9b01c92b638c6f9b104ea9 586 SUPERFAMILY SSF48452 554 586 1.23E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12365 8058d6558a9b01c92b638c6f9b104ea9 586 SUPERFAMILY SSF48452 20 522 1.23E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12365 8058d6558a9b01c92b638c6f9b104ea9 586 Pfam PF07980 SusD family 279 586 7.3E-51 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13285 78f584961eada4f1a03be80842c3b667 93 PANTHER PTHR38039 4 91 1.8E-15 T 21-04-2016 SPH21_RS13285 78f584961eada4f1a03be80842c3b667 93 TIGRFAM TIGR02116 toxin_Txe_YoeB: addiction module toxin, Txe/YoeB family 11 90 5.9E-18 T 21-04-2016 IPR009614 Toxin YoeB GO:0004519|GO:0006401 SPH21_RS13285 78f584961eada4f1a03be80842c3b667 93 PANTHER PTHR38039:SF1 4 91 1.8E-15 T 21-04-2016 SPH21_RS13285 78f584961eada4f1a03be80842c3b667 93 TIGRFAM TIGR02385 RelE_StbE: addiction module toxin, RelE/StbE family 6 88 3.7E-7 T 21-04-2016 IPR007712 Toxin-antitoxin system, RelE/ParE toxin family SPH21_RS13285 78f584961eada4f1a03be80842c3b667 93 Pfam PF06769 YoeB-like toxin of bacterial type II toxin-antitoxin system 19 90 2.3E-16 T 21-04-2016 IPR009614 Toxin YoeB GO:0004519|GO:0006401 SPH21_RS13285 78f584961eada4f1a03be80842c3b667 93 SUPERFAMILY SSF143011 4 84 1.83E-16 T 21-04-2016 SPH21_RS20640 878c9ad74727a9b82e1d6eb98da17974 287 PANTHER PTHR12110:SF23 16 282 3.1E-41 T 21-04-2016 SPH21_RS20640 878c9ad74727a9b82e1d6eb98da17974 287 SUPERFAMILY SSF51658 22 280 1.22E-34 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS20640 878c9ad74727a9b82e1d6eb98da17974 287 Gene3D G3DSA:3.20.20.150 18 282 1.7E-47 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS20640 878c9ad74727a9b82e1d6eb98da17974 287 Pfam PF01261 Xylose isomerase-like TIM barrel 43 237 7.2E-13 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS20640 878c9ad74727a9b82e1d6eb98da17974 287 PANTHER PTHR12110 16 282 3.1E-41 T 21-04-2016 SPH21_RS18265 6317b1503ee0c77d498a23c9e3983dfb 290 SUPERFAMILY SSF103481 187 289 2.88E-10 T 21-04-2016 SPH21_RS18265 6317b1503ee0c77d498a23c9e3983dfb 290 Pfam PF00892 EamA-like transporter family 152 287 9.7E-13 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS18265 6317b1503ee0c77d498a23c9e3983dfb 290 Pfam PF00892 EamA-like transporter family 9 139 6.8E-19 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS18265 6317b1503ee0c77d498a23c9e3983dfb 290 PANTHER PTHR12715 9 290 8.8E-39 T 21-04-2016 SPH21_RS18265 6317b1503ee0c77d498a23c9e3983dfb 290 SUPERFAMILY SSF103481 44 141 1.83E-14 T 21-04-2016 SPH21_RS15045 35c0cbce040af9a3eea7e5bd11c2208c 206 SUPERFAMILY SSF117070 88 150 1.07E-6 T 21-04-2016 SPH21_RS15045 35c0cbce040af9a3eea7e5bd11c2208c 206 Gene3D G3DSA:2.60.40.10 89 199 1.6E-4 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PANTHER PTHR11670 1 307 1.6E-212 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PANTHER PTHR11670 325 464 1.6E-212 T 21-04-2016 IPR015937 Aconitase/isopropylmalate dehydratase GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 TIGRFAM TIGR00170 leuC: 3-isopropylmalate dehydratase, large subunit 1 461 2.3E-193 T 21-04-2016 IPR004430 3-isopropylmalate dehydratase, large subunit GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 Gene3D G3DSA:3.30.499.10 330 463 5.3E-54 T 21-04-2016 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 Pfam PF00330 Aconitase family (aconitate hydratase) 7 455 4.7E-143 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 SUPERFAMILY SSF53732 1 463 3.01E-158 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 ProSitePatterns PS01244 Aconitase family signature 2. 397 410 - T 21-04-2016 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PANTHER PTHR11670:SF12 1 307 1.6E-212 T 21-04-2016 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PANTHER PTHR11670:SF12 325 464 1.6E-212 T 21-04-2016 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 Hamap MF_01026 3-isopropylmalate dehydratase large subunit [leuC]. 1 464 51.674 T 21-04-2016 IPR004430 3-isopropylmalate dehydratase, large subunit GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 Gene3D G3DSA:3.40.1060.10 166 280 1.1E-37 T 21-04-2016 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 108 116 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 209 222 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 397 410 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 133 148 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 119 132 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 195 208 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 82 95 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 341 352 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 PRINTS PR00415 Aconitase family signature 286 300 3.4E-43 T 21-04-2016 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS11240 d422d677a612ad4d631c0dfa05b47cd5 464 Gene3D G3DSA:3.30.499.10 2 163 2.8E-23 T 21-04-2016 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33|UniPathway: UPA00048 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 PANTHER PTHR14413 1 119 6.2E-58 T 21-04-2016 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 ProSitePatterns PS01167 Ribosomal protein L17 signature. 34 56 - T 21-04-2016 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 Gene3D G3DSA:3.90.1030.10 1 117 6.7E-46 T 21-04-2016 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 Hamap MF_01368 50S ribosomal protein L17 [rplQ]. 5 116 26.305 T 21-04-2016 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 PANTHER PTHR14413:SF5 1 119 6.2E-58 T 21-04-2016 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 SUPERFAMILY SSF64263 1 119 3.79E-46 T 21-04-2016 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 TIGRFAM TIGR00059 L17: ribosomal protein bL17 7 117 4.4E-40 T 21-04-2016 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08630 2896644e44887e84717c44c799c8e88e 199 Pfam PF01196 Ribosomal protein L17 20 116 2.4E-32 T 21-04-2016 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS23855 85f9ee81096cc09fb0e94dcfb34514f6 319 Pfam PF06996 Type VI secretion, VasB, ImpH, VC_A0111 172 314 9.2E-12 T 21-04-2016 IPR010732 Type VI secretion, TssG-like SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 ProSitePatterns PS00300 SRP54-type proteins GTP-binding domain signature. 293 306 - T 21-04-2016 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 Pfam PF00448 SRP54-type protein, GTPase domain 120 319 3.1E-74 T 21-04-2016 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 SUPERFAMILY SSF52540 117 319 8.33E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 Pfam PF02881 SRP54-type protein, helical bundle domain 33 96 8.8E-12 T 21-04-2016 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 SMART SM00382 118 265 4.3E-6 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 PANTHER PTHR11564 10 320 6.4E-129 T 21-04-2016 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 SMART SM00962 119 320 5.5E-108 T 21-04-2016 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 TIGRFAM TIGR00064 ftsY: signal recognition particle-docking protein FtsY 45 319 3.4E-105 T 21-04-2016 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 SUPERFAMILY SSF47364 18 95 1.31E-18 T 21-04-2016 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 Gene3D G3DSA:3.40.50.300 116 319 2.9E-77 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 SMART SM00963 20 101 1.3E-18 T 21-04-2016 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: REACT_15380 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 PANTHER PTHR11564:SF16 10 320 6.4E-129 T 21-04-2016 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 Hamap MF_00920 Signal recognition particle receptor FtsY [ftsY]. 44 320 58.293 T 21-04-2016 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 SPH21_RS25525 133383328a2fd0d25382bdff31f07581 320 Gene3D G3DSA:1.20.120.140 22 105 1.7E-27 T 21-04-2016 SPH21_RS25850 2ffb24f27dd7323ce6f2ea47ba1d1416 341 Gene3D G3DSA:2.130.10.140 41 315 9.4E-26 T 21-04-2016 SPH21_RS25850 2ffb24f27dd7323ce6f2ea47ba1d1416 341 Pfam PF14870 Photosynthesis system II assembly factor YCF48 36 114 7.9E-11 T 21-04-2016 IPR028203 Photosynthesis system II assembly factor Ycf48/Hcf136-like domain SPH21_RS25850 2ffb24f27dd7323ce6f2ea47ba1d1416 341 SUPERFAMILY SSF110296 40 267 1.36E-24 T 21-04-2016 SPH21_RS09100 6dd00c459d266d51e4b1cdc3e80ad0f3 194 SUPERFAMILY SSF46689 11 75 2.57E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09100 6dd00c459d266d51e4b1cdc3e80ad0f3 194 SUPERFAMILY SSF48498 82 188 6.47E-13 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS09100 6dd00c459d266d51e4b1cdc3e80ad0f3 194 PANTHER PTHR30055 1 191 3.1E-27 T 21-04-2016 SPH21_RS09100 6dd00c459d266d51e4b1cdc3e80ad0f3 194 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 58 2.0E-10 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS09100 6dd00c459d266d51e4b1cdc3e80ad0f3 194 Gene3D G3DSA:1.10.357.10 4 181 1.4E-28 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS09100 6dd00c459d266d51e4b1cdc3e80ad0f3 194 PANTHER PTHR30055:SF34 1 191 3.1E-27 T 21-04-2016 SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 SUPERFAMILY SSF52172 2 119 2.56E-26 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 Pfam PF00072 Response regulator receiver domain 6 111 2.0E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 Pfam PF04397 LytTr DNA-binding domain 141 229 2.0E-15 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 SMART SM00448 2 110 5.7E-19 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 Gene3D G3DSA:3.40.50.2300 1 116 1.1E-26 T 21-04-2016 SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 Gene3D G3DSA:2.40.50.40 134 200 6.5E-16 T 21-04-2016 SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 SMART SM00850 140 233 3.5E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS01265 5a8d29ed50df4b05c1b57f98c7acab74 235 PANTHER PTHR26402 2 116 1.6E-26 T 21-04-2016 SPH21_RS14885 48e0d3ddb41a3135fc43194e32b55e44 215 Hamap MF_01043 Glycerol-3-phosphate acyltransferase [plsY]. 8 208 19.703 T 21-04-2016 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 UniPathway: UPA00085 SPH21_RS14885 48e0d3ddb41a3135fc43194e32b55e44 215 SMART SM01207 11 200 2.3E-71 T 21-04-2016 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 UniPathway: UPA00085 SPH21_RS14885 48e0d3ddb41a3135fc43194e32b55e44 215 PANTHER PTHR30309 1 207 1.6E-65 T 21-04-2016 SPH21_RS14885 48e0d3ddb41a3135fc43194e32b55e44 215 TIGRFAM TIGR00023 TIGR00023: acyl-phosphate glycerol 3-phosphate acyltransferase 6 208 1.5E-54 T 21-04-2016 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 UniPathway: UPA00085 SPH21_RS14885 48e0d3ddb41a3135fc43194e32b55e44 215 PANTHER PTHR30309:SF0 1 207 1.6E-65 T 21-04-2016 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 UniPathway: UPA00085 SPH21_RS14885 48e0d3ddb41a3135fc43194e32b55e44 215 Pfam PF02660 Glycerol-3-phosphate acyltransferase 12 199 9.5E-52 T 21-04-2016 IPR003811 Glycerol-3-phosphate acyltransferase, PlsY GO:0005886|GO:0008654|GO:0043772 UniPathway: UPA00085 SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 Pfam PF00772 DnaB-like helicase N terminal domain 37 137 1.4E-32 T 21-04-2016 IPR007693 DNA helicase, DnaB-like, N-terminal GO:0003678|GO:0005524|GO:0006260 SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 Pfam PF03796 DnaB-like helicase C terminal domain 212 476 4.7E-107 T 21-04-2016 IPR007694 DNA helicase, DnaB-like, C-terminal GO:0003678|GO:0005524|GO:0006260 SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 Gene3D G3DSA:3.40.50.300 197 479 1.5E-96 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 PANTHER PTHR30153 21 486 6.1E-190 T 21-04-2016 SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 Gene3D G3DSA:1.10.860.10 37 139 3.0E-35 T 21-04-2016 IPR016136 DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 SUPERFAMILY SSF52540 210 469 9.21E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 SUPERFAMILY SSF48024 35 147 1.44E-33 T 21-04-2016 IPR007693 DNA helicase, DnaB-like, N-terminal GO:0003678|GO:0005524|GO:0006260 SPH21_RS15210 c960d971866587e88c357f511f3cc37f 530 TIGRFAM TIGR00665 DnaB: replicative DNA helicase 36 478 2.5E-165 T 21-04-2016 IPR007692 DNA helicase, DnaB type GO:0003677|GO:0003678|GO:0005524|GO:0006260 SPH21_RS04720 29d48ae18978986124a19c99f460dd8a 188 Pfam PF14066 Protein of unknown function (DUF4256) 16 188 1.5E-94 T 21-04-2016 IPR025352 Protein of unknown function DUF4256 SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 SUPERFAMILY SSF51735 2 242 2.67E-62 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 145 164 6.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 6.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 125 133 6.3E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 183 2.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 2.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 119 135 2.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 164 2.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 2.9E-25 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 Pfam PF00106 short chain dehydrogenase 3 185 2.6E-48 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PANTHER PTHR24322 145 176 6.1E-49 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 PANTHER PTHR24322 7 129 6.1E-49 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 132 160 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS21655 cf3363ff47c4b39cfc083b15f2546fdb 268 Gene3D G3DSA:3.40.50.720 2 244 8.1E-66 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PANTHER PTHR24322:SF397 8 136 6.5E-46 T 21-04-2016 SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PANTHER PTHR24322:SF397 152 185 6.5E-46 T 21-04-2016 SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 Pfam PF00106 short chain dehydrogenase 4 195 7.3E-47 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PANTHER PTHR24322 8 136 6.5E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PANTHER PTHR24322 152 185 6.5E-46 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 7.1E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 7.1E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 7.1E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 7.1E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 7.1E-22 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 Gene3D G3DSA:3.40.50.720 3 245 3.1E-62 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 SUPERFAMILY SSF51735 3 245 1.46E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 2.2E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 2.2E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21710 49424f530ac5186581a08da9661ef485 288 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 2.2E-10 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS24735 5e76b83489723c57d61ce292dcf26541 168 PANTHER PTHR11106 2 168 2.0E-84 T 21-04-2016 SPH21_RS24735 5e76b83489723c57d61ce292dcf26541 168 Pfam PF01661 Macro domain 18 134 7.4E-47 T 21-04-2016 IPR002589 Macro domain SPH21_RS24735 5e76b83489723c57d61ce292dcf26541 168 SUPERFAMILY SSF52949 1 167 8.24E-67 T 21-04-2016 SPH21_RS24735 5e76b83489723c57d61ce292dcf26541 168 SMART SM00506 1 134 2.3E-54 T 21-04-2016 IPR002589 Macro domain SPH21_RS24735 5e76b83489723c57d61ce292dcf26541 168 Gene3D G3DSA:3.40.220.10 2 168 4.0E-71 T 21-04-2016 SPH21_RS15240 fc76b68ba8a57bd606d1fe64a5fdf31e 113 Gene3D G3DSA:1.25.40.10 7 99 1.6E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS15240 fc76b68ba8a57bd606d1fe64a5fdf31e 113 Pfam PF13174 Tetratricopeptide repeat 23 52 0.0084 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS15240 fc76b68ba8a57bd606d1fe64a5fdf31e 113 SUPERFAMILY SSF48452 9 97 3.54E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS15240 fc76b68ba8a57bd606d1fe64a5fdf31e 113 SMART SM00028 20 53 2.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS15240 fc76b68ba8a57bd606d1fe64a5fdf31e 113 SMART SM00028 54 87 9.7 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS09785 a0f738c24497553c0b50d12884056047 382 PANTHER PTHR10091:SF0 17 382 1.5E-153 T 21-04-2016 SPH21_RS09785 a0f738c24497553c0b50d12884056047 382 Pfam PF01263 Aldose 1-epimerase 50 378 2.9E-89 T 21-04-2016 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 SPH21_RS09785 a0f738c24497553c0b50d12884056047 382 SUPERFAMILY SSF74650 37 380 2.13E-112 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS09785 a0f738c24497553c0b50d12884056047 382 PIRSF PIRSF005096 30 382 8.9E-129 T 21-04-2016 IPR015443 Aldose 1-epimerase GO:0016853|GO:0019318 KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317|UniPathway: UPA00242 SPH21_RS09785 a0f738c24497553c0b50d12884056047 382 PANTHER PTHR10091 17 382 1.5E-153 T 21-04-2016 SPH21_RS09785 a0f738c24497553c0b50d12884056047 382 Gene3D G3DSA:2.70.98.10 38 381 7.5E-129 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS14565 7df263201f68f09071bb591556b8a2ac 272 PANTHER PTHR21234 21 260 3.0E-64 T 21-04-2016 IPR018017 Nucleoside phosphorylase SPH21_RS14565 7df263201f68f09071bb591556b8a2ac 272 Gene3D G3DSA:3.40.50.1580 18 263 2.2E-64 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS14565 7df263201f68f09071bb591556b8a2ac 272 Pfam PF01048 Phosphorylase superfamily 78 232 6.5E-23 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS14565 7df263201f68f09071bb591556b8a2ac 272 TIGRFAM TIGR01721 AMN-like: putative AMP nucleosidase 18 261 2.3E-102 T 21-04-2016 IPR010944 AMP nucleosidase, putative SPH21_RS14565 7df263201f68f09071bb591556b8a2ac 272 SUPERFAMILY SSF53167 18 264 1.06E-61 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS14565 7df263201f68f09071bb591556b8a2ac 272 PANTHER PTHR21234:SF11 21 260 3.0E-64 T 21-04-2016 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 Pfam PF04389 Peptidase family M28 250 437 2.3E-34 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 SUPERFAMILY SSF53187 37 90 6.29E-52 T 21-04-2016 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 SUPERFAMILY SSF53187 242 452 6.29E-52 T 21-04-2016 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 Gene3D G3DSA:3.50.30.30 110 235 1.2E-14 T 21-04-2016 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 PANTHER PTHR12147 207 452 3.9E-33 T 21-04-2016 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 Pfam PF02225 PA domain 133 223 9.0E-7 T 21-04-2016 IPR003137 PA domain SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 SUPERFAMILY SSF52025 117 230 2.88E-11 T 21-04-2016 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 Gene3D G3DSA:3.40.630.10 37 94 9.1E-60 T 21-04-2016 SPH21_RS05340 1cb74686a623ea98e876fb44f9395b2d 487 Gene3D G3DSA:3.40.630.10 249 454 9.1E-60 T 21-04-2016 SPH21_RS06620 21a219bf8e3246747a5e07ab6af52faf 185 SUPERFAMILY SSF52218 1 169 2.1E-39 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS06620 21a219bf8e3246747a5e07ab6af52faf 185 PANTHER PTHR30543:SF1 1 185 2.0E-49 T 21-04-2016 SPH21_RS06620 21a219bf8e3246747a5e07ab6af52faf 185 PANTHER PTHR30543 1 185 2.0E-49 T 21-04-2016 SPH21_RS06620 21a219bf8e3246747a5e07ab6af52faf 185 Pfam PF03358 NADPH-dependent FMN reductase 6 141 1.7E-36 T 21-04-2016 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SPH21_RS06620 21a219bf8e3246747a5e07ab6af52faf 185 Gene3D G3DSA:3.40.50.360 6 182 1.4E-48 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS21720 70aeac85b51faa8bede2c0d36f904241 786 Pfam PF02687 FtsX-like permease family 283 440 9.2E-12 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS21720 70aeac85b51faa8bede2c0d36f904241 786 Pfam PF02687 FtsX-like permease family 666 775 1.5E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS21720 70aeac85b51faa8bede2c0d36f904241 786 Pfam PF12704 MacB-like periplasmic core domain 20 237 2.3E-24 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS21720 70aeac85b51faa8bede2c0d36f904241 786 PANTHER PTHR30572 394 786 2.3E-58 T 21-04-2016 SPH21_RS21720 70aeac85b51faa8bede2c0d36f904241 786 PANTHER PTHR30572 277 345 2.3E-58 T 21-04-2016 SPH21_RS21720 70aeac85b51faa8bede2c0d36f904241 786 PANTHER PTHR30572:SF4 394 786 2.3E-58 T 21-04-2016 SPH21_RS21720 70aeac85b51faa8bede2c0d36f904241 786 PANTHER PTHR30572:SF4 277 345 2.3E-58 T 21-04-2016 SPH21_RS22715 fe493d5cf9d64c96a72f7406aff0c660 487 Pfam PF13351 Protein of unknown function (DUF4099) 148 229 6.4E-30 T 21-04-2016 IPR025343 Protein of unknown function DUF4099 SPH21_RS22715 fe493d5cf9d64c96a72f7406aff0c660 487 Pfam PF13101 Protein of unknown function (DUF3945) 366 398 3.1E-4 T 21-04-2016 IPR025222 Protein of unknown function DUF3945 SPH21_RS22715 fe493d5cf9d64c96a72f7406aff0c660 487 Pfam PF13101 Protein of unknown function (DUF3945) 263 321 5.3E-25 T 21-04-2016 IPR025222 Protein of unknown function DUF3945 SPH21_RS11630 9d33af76a19254c659cceb80628d1149 492 Pfam PF14322 Starch-binding associating with outer membrane 24 227 1.7E-32 T 21-04-2016 SPH21_RS11630 9d33af76a19254c659cceb80628d1149 492 Pfam PF07980 SusD family 354 492 8.2E-34 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS11630 9d33af76a19254c659cceb80628d1149 492 SUPERFAMILY SSF48452 20 492 2.66E-114 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11630 9d33af76a19254c659cceb80628d1149 492 Gene3D G3DSA:1.25.40.10 211 314 1.6E-36 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11630 9d33af76a19254c659cceb80628d1149 492 Gene3D G3DSA:1.25.40.10 346 429 1.6E-36 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09165 36d66c49b73e35fd6bfa6a9fd3320158 196 Gene3D G3DSA:2.60.120.10 2 132 2.7E-10 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS09165 36d66c49b73e35fd6bfa6a9fd3320158 196 SUPERFAMILY SSF51206 19 125 2.88E-9 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 186 0.0068 T 21-04-2016 SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 PANTHER PTHR24322 10 134 8.3E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 PANTHER PTHR24322 150 182 8.3E-45 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 Gene3D G3DSA:3.40.50.720 2 242 3.8E-75 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 SUPERFAMILY SSF51735 1 242 2.21E-72 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 241 1.9E-53 T 21-04-2016 SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 1.8E-30 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 1.8E-30 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 1.8E-30 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 1.8E-30 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS20765 5097139f46c730a918eb1c2944db6be7 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 205 225 1.8E-30 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 PANTHER PTHR15184:SF3 334 509 4.2E-291 T 21-04-2016 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 PANTHER PTHR15184:SF3 1 315 4.2E-291 T 21-04-2016 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 SUPERFAMILY SSF47917 397 522 4.71E-39 T 21-04-2016 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 PANTHER PTHR15184 334 509 4.2E-291 T 21-04-2016 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 PANTHER PTHR15184 1 315 4.2E-291 T 21-04-2016 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 Gene3D G3DSA:1.20.150.20 397 523 2.7E-47 T 21-04-2016 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 Gene3D G3DSA:2.40.30.20 3 94 2.7E-38 T 21-04-2016 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 PIRSF PIRSF039088 2 524 1.8E-247 T 21-04-2016 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 SUPERFAMILY SSF52540 97 395 9.92E-92 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 380 389 - T 21-04-2016 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 Gene3D G3DSA:3.40.50.300 96 396 1.1E-113 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 SUPERFAMILY SSF50615 11 95 2.28E-28 T 21-04-2016 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 TIGRFAM TIGR00962 atpA: ATP synthase F1, alpha subunit 4 522 2.8E-237 T 21-04-2016 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 27 93 6.2E-17 T 21-04-2016 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 Pfam PF00306 ATP synthase alpha/beta chain, C terminal domain 396 519 2.2E-43 T 21-04-2016 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 151 389 1.1E-69 T 21-04-2016 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS25755 63770d4cec64b4cfc52eadb737f8d0a1 524 Hamap MF_01346 ATP synthase subunit alpha [atpA]. 2 521 48.88 T 21-04-2016 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 PRINTS PR01486 Bacterial phospholipase A1 protein signature 155 173 3.8E-15 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 PRINTS PR01486 Bacterial phospholipase A1 protein signature 112 131 3.8E-15 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 PRINTS PR01486 Bacterial phospholipase A1 protein signature 188 206 3.8E-15 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 PRINTS PR01486 Bacterial phospholipase A1 protein signature 69 86 3.8E-15 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 PRINTS PR01486 Bacterial phospholipase A1 protein signature 248 268 3.8E-15 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 Pfam PF02253 Phospholipase A1 49 275 3.7E-51 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 Gene3D G3DSA:2.40.230.10 45 277 3.9E-62 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 SUPERFAMILY SSF56931 43 276 8.37E-64 T 21-04-2016 IPR003187 Phospholipase A1 GO:0004620|GO:0006629|GO:0016020 KEGG: 00564+3.1.1.32+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.32+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SPH21_RS22080 2b9ce918491aea37f09c04e565ba7ccc 283 PANTHER PTHR40457 48 279 2.8E-24 T 21-04-2016 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 Pfam PF02954 Bacterial regulatory protein, Fis family 372 408 2.7E-10 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 PANTHER PTHR32071 325 412 1.2E-143 T 21-04-2016 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 PANTHER PTHR32071 4 263 1.2E-143 T 21-04-2016 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 ProSitePatterns PS00688 Sigma-54 interaction domain C-terminal part signature. 225 234 - T 21-04-2016 IPR025944 Sigma-54 interaction domain, conserved site SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 SUPERFAMILY SSF46689 367 411 2.01E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 Gene3D G3DSA:3.40.50.300 10 184 3.2E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 Pfam PF00158 Sigma-54 interaction domain 12 178 9.5E-66 T 21-04-2016 IPR002078 RNA polymerase sigma factor 54 interaction domain GO:0005524|GO:0006355|GO:0008134 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 Gene3D G3DSA:1.10.10.60 364 407 4.8E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 375 392 2.4E-8 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 392 412 2.4E-8 T 21-04-2016 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 SMART SM00382 32 175 5.2E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 SUPERFAMILY SSF52540 11 255 5.68E-69 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 Gene3D G3DSA:1.10.8.60 185 263 3.7E-23 T 21-04-2016 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 ProSitePatterns PS00675 Sigma-54 interaction domain ATP-binding region A signature. 36 49 - T 21-04-2016 IPR025662 Sigma-54 interaction domain, ATP-binding site 1 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 PANTHER PTHR32071:SF23 325 412 1.2E-143 T 21-04-2016 SPH21_RS03690 d04c5438b22596855d447c9fa1b941fa 412 PANTHER PTHR32071:SF23 4 263 1.2E-143 T 21-04-2016 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 PANTHER PTHR11910 4 176 1.3E-49 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 Gene3D G3DSA:1.10.520.20 4 106 2.1E-18 T 21-04-2016 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 Hamap MF_01416 ATP synthase subunit delta [atpD]. 2 178 18.624 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 TIGRFAM TIGR01145 ATP_synt_delta: ATP synthase F1, delta subunit 6 174 2.7E-36 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 Pfam PF00213 ATP synthase delta (OSCP) subunit 6 175 1.4E-47 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 PRINTS PR00125 ATP synthase delta subunit signature 75 86 5.1E-20 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 PRINTS PR00125 ATP synthase delta subunit signature 6 25 5.1E-20 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 PRINTS PR00125 ATP synthase delta subunit signature 151 169 5.1E-20 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 PRINTS PR00125 ATP synthase delta subunit signature 136 151 5.1E-20 T 21-04-2016 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 SPH21_RS25760 1f5faa0d8caadc3eb374a930637c932b 178 SUPERFAMILY SSF47928 2 107 6.54E-23 T 21-04-2016 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain SPH21_RS11325 74210879a7d9526b606893f03cd76d43 328 Pfam PF12127 SigmaW regulon antibacterial 8 319 2.7E-163 T 21-04-2016 IPR022853 Uncharacterised protein family YdfA-immunity SPH21_RS11325 74210879a7d9526b606893f03cd76d43 328 Hamap MF_01562 UPF0365 protein . 2 322 47.851 T 21-04-2016 IPR022853 Uncharacterised protein family YdfA-immunity SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 PANTHER PTHR11573 2 792 0.0 T 21-04-2016 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 ProSitePatterns PS00089 Ribonucleotide reductase large subunit signature. 581 603 - T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 Pfam PF03477 ATP cone domain 1 89 6.6E-20 T 21-04-2016 IPR005144 ATP-cone domain SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 142 212 5.1E-25 T 21-04-2016 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 Gene3D G3DSA:3.20.70.20 389 546 4.0E-64 T 21-04-2016 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 Gene3D G3DSA:3.20.70.20 592 651 4.0E-64 T 21-04-2016 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 Gene3D G3DSA:3.20.70.20 139 339 4.0E-64 T 21-04-2016 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 SUPERFAMILY SSF51998 215 642 4.27E-190 T 21-04-2016 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 SUPERFAMILY SSF51998 675 751 4.27E-190 T 21-04-2016 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 SUPERFAMILY SSF48168 6 214 3.92E-70 T 21-04-2016 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 PRINTS PR01183 Ribonucleotide reductase large chain signature 592 619 8.6E-58 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 PRINTS PR01183 Ribonucleotide reductase large chain signature 460 483 8.6E-58 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 PRINTS PR01183 Ribonucleotide reductase large chain signature 423 434 8.6E-58 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 PRINTS PR01183 Ribonucleotide reductase large chain signature 293 312 8.6E-58 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 PRINTS PR01183 Ribonucleotide reductase large chain signature 526 549 8.6E-58 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 PRINTS PR01183 Ribonucleotide reductase large chain signature 498 520 8.6E-58 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 TIGRFAM TIGR02506 NrdE_NrdA: ribonucleoside-diphosphate reductase, alpha subunit 145 742 1.5E-219 T 21-04-2016 IPR013346 Ribonucleotide reductase, class I , alpha subunit GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|UniPathway: UPA00326 SPH21_RS01655 18c8446ae5df2a0c767a68047e04af25 792 Pfam PF02867 Ribonucleotide reductase, barrel domain 216 738 1.0E-184 T 21-04-2016 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 Gene3D G3DSA:3.40.50.720 1 189 9.4E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 Hamap MF_00955 GDP-mannose 4,6-dehydratase [gmd]. 2 355 55.401 T 21-04-2016 IPR006368 GDP-mannose 4,6-dehydratase GO:0008446|GO:0019673 KEGG: 00051+4.2.1.47|KEGG: 00520+4.2.1.47|MetaCyc: PWY-5738|MetaCyc: PWY-5739|MetaCyc: PWY-5740|MetaCyc: PWY-66|MetaCyc: PWY-7573|UniPathway: UPA00128 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 SUPERFAMILY SSF51735 2 350 1.32E-81 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 TIGRFAM TIGR01472 gmd: GDP-mannose 4,6-dehydratase 2 352 1.2E-178 T 21-04-2016 IPR006368 GDP-mannose 4,6-dehydratase GO:0008446|GO:0019673 KEGG: 00051+4.2.1.47|KEGG: 00520+4.2.1.47|MetaCyc: PWY-5738|MetaCyc: PWY-5739|MetaCyc: PWY-5740|MetaCyc: PWY-66|MetaCyc: PWY-7573|UniPathway: UPA00128 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 Gene3D G3DSA:3.90.25.10 192 246 4.2E-49 T 21-04-2016 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 Gene3D G3DSA:3.90.25.10 303 358 4.2E-49 T 21-04-2016 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 PANTHER PTHR10366 309 362 3.3E-206 T 21-04-2016 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 PANTHER PTHR10366 3 281 3.3E-206 T 21-04-2016 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 Pfam PF16363 GDP-mannose 4,6 dehydratase 5 345 4.2E-156 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 PANTHER PTHR10366:SF32 309 362 3.3E-206 T 21-04-2016 SPH21_RS09585 a85f68a119a59bd821d65abe59bf62e5 366 PANTHER PTHR10366:SF32 3 281 3.3E-206 T 21-04-2016 SPH21_RS20230 0a4006a286eb9a00fbd8bd6f2db0aab0 137 Pfam PF01638 HxlR-like helix-turn-helix 14 101 2.8E-15 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS20230 0a4006a286eb9a00fbd8bd6f2db0aab0 137 Gene3D G3DSA:1.10.10.10 3 99 2.1E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20230 0a4006a286eb9a00fbd8bd6f2db0aab0 137 PANTHER PTHR33204:SF10 4 99 4.0E-22 T 21-04-2016 SPH21_RS20230 0a4006a286eb9a00fbd8bd6f2db0aab0 137 PANTHER PTHR33204 4 99 4.0E-22 T 21-04-2016 SPH21_RS20230 0a4006a286eb9a00fbd8bd6f2db0aab0 137 SUPERFAMILY SSF46785 3 107 1.11E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24845 f3e5807d0d17dc1eedc9a380f572af11 227 Pfam PF04542 Sigma-70 region 2 16 58 1.0E-4 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24845 f3e5807d0d17dc1eedc9a380f572af11 227 SUPERFAMILY SSF88946 15 86 1.8E-6 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24845 f3e5807d0d17dc1eedc9a380f572af11 227 Gene3D G3DSA:1.10.1740.10 15 91 6.4E-8 T 21-04-2016 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 ProSitePatterns PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 266 291 - T 21-04-2016 IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 PIRSF PIRSF001554 1 396 1.8E-142 T 21-04-2016 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: REACT_1046|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 Gene3D G3DSA:3.30.1490.20 21 98 4.0E-33 T 21-04-2016 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 Gene3D G3DSA:3.40.50.261 250 393 6.8E-62 T 21-04-2016 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 PANTHER PTHR11815 1 396 1.1E-206 T 21-04-2016 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: REACT_1046|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 PANTHER PTHR11815:SF1 1 396 1.1E-206 T 21-04-2016 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 Gene3D G3DSA:3.30.470.20 99 248 1.9E-54 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 Pfam PF08442 ATP-grasp domain 2 210 1.4E-70 T 21-04-2016 IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 Pfam PF00549 CoA-ligase 271 388 7.3E-25 T 21-04-2016 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 TIGRFAM TIGR01016 sucCoAbeta: succinate-CoA ligase, beta subunit 1 393 8.7E-143 T 21-04-2016 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: REACT_1046|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 Hamap MF_00558 Succinyl-CoA ligase [ADP-forming] subunit beta [sucC]. 1 396 39.727 T 21-04-2016 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: REACT_1046|UniPathway: UPA00223 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 SUPERFAMILY SSF56059 1 247 2.12E-74 T 21-04-2016 SPH21_RS16625 34bfca33f9754296061634c345f96dd2 396 SUPERFAMILY SSF52210 248 392 4.32E-50 T 21-04-2016 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|UniPathway: UPA00223 SPH21_RS04120 ae4306bae4812947f386665c40af8fe6 259 PANTHER PTHR14859 1 259 5.4E-41 T 21-04-2016 IPR027317 PGAP2-interacting protein SPH21_RS04120 ae4306bae4812947f386665c40af8fe6 259 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 33 248 2.2E-23 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS04120 ae4306bae4812947f386665c40af8fe6 259 Gene3D G3DSA:3.60.10.10 208 256 1.4E-4 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS04120 ae4306bae4812947f386665c40af8fe6 259 Gene3D G3DSA:3.60.10.10 30 195 1.7E-18 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS04120 ae4306bae4812947f386665c40af8fe6 259 PANTHER PTHR14859:SF0 1 259 5.4E-41 T 21-04-2016 SPH21_RS04120 ae4306bae4812947f386665c40af8fe6 259 SUPERFAMILY SSF56219 26 257 1.1E-40 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS25910 81dc2647c83ed60758a8d803c3151d3b 137 SUPERFAMILY SSF82784 1 133 2.88E-28 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS25910 81dc2647c83ed60758a8d803c3151d3b 137 Pfam PF02566 OsmC-like protein 35 130 3.0E-15 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS25910 81dc2647c83ed60758a8d803c3151d3b 137 PANTHER PTHR39624:SF2 1 128 2.1E-17 T 21-04-2016 SPH21_RS25910 81dc2647c83ed60758a8d803c3151d3b 137 Gene3D G3DSA:3.30.300.20 1 136 3.3E-53 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS25910 81dc2647c83ed60758a8d803c3151d3b 137 PANTHER PTHR39624 1 128 2.1E-17 T 21-04-2016 SPH21_RS18835 774eeab0970688ae02c655c46826b621 120 PANTHER PTHR26402:SF596 3 117 2.9E-17 T 21-04-2016 SPH21_RS18835 774eeab0970688ae02c655c46826b621 120 Gene3D G3DSA:3.40.50.2300 3 118 5.3E-22 T 21-04-2016 SPH21_RS18835 774eeab0970688ae02c655c46826b621 120 Pfam PF00072 Response regulator receiver domain 5 113 8.3E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18835 774eeab0970688ae02c655c46826b621 120 SMART SM00448 3 113 2.9E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18835 774eeab0970688ae02c655c46826b621 120 PANTHER PTHR26402 3 117 2.9E-17 T 21-04-2016 SPH21_RS18835 774eeab0970688ae02c655c46826b621 120 SUPERFAMILY SSF52172 5 118 2.28E-20 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10980 e5ce312ceb599c3f263313e5c73ba431 183 Gene3D G3DSA:3.40.50.2020 3 173 1.5E-37 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS10980 e5ce312ceb599c3f263313e5c73ba431 183 PANTHER PTHR11608 1 181 1.4E-53 T 21-04-2016 SPH21_RS10980 e5ce312ceb599c3f263313e5c73ba431 183 SUPERFAMILY SSF53271 4 175 1.57E-33 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS10980 e5ce312ceb599c3f263313e5c73ba431 183 Pfam PF00156 Phosphoribosyl transferase domain 3 155 5.6E-17 T 21-04-2016 IPR000836 Phosphoribosyltransferase domain GO:0009116 SPH21_RS15690 5ba112bed7b6c92ec8a6f1db3c595df8 216 Hamap MF_01208 Orotate phosphoribosyltransferase [pyrE]. 1 216 27.483 T 21-04-2016 IPR023031 Orotate phosphoribosyltransferase GO:0004588|GO:0006221 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS15690 5ba112bed7b6c92ec8a6f1db3c595df8 216 SUPERFAMILY SSF53271 13 212 7.6E-52 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS15690 5ba112bed7b6c92ec8a6f1db3c595df8 216 Gene3D G3DSA:3.40.50.2020 7 212 7.8E-59 T 21-04-2016 IPR029057 Phosphoribosyltransferase-like SPH21_RS15690 5ba112bed7b6c92ec8a6f1db3c595df8 216 Pfam PF00156 Phosphoribosyl transferase domain 48 166 8.9E-20 T 21-04-2016 IPR000836 Phosphoribosyltransferase domain GO:0009116 SPH21_RS15690 5ba112bed7b6c92ec8a6f1db3c595df8 216 TIGRFAM TIGR00336 pyrE: orotate phosphoribosyltransferase 13 181 1.6E-41 T 21-04-2016 IPR004467 Orotate phosphoribosyl transferase domain GO:0004588 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|UniPathway: UPA00070 SPH21_RS15690 5ba112bed7b6c92ec8a6f1db3c595df8 216 PANTHER PTHR19278 1 212 6.0E-60 T 21-04-2016 SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 Gene3D G3DSA:1.10.2020.10 46 135 3.5E-43 T 21-04-2016 IPR023177 Uronate isomerase, domain 2 GO:0008880 KEGG: 00040+5.3.1.12|MetaCyc: PWY-7247|MetaCyc: PWY-7248|UniPathway: UPA00246 SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 Gene3D G3DSA:3.20.20.140 3 44 2.5E-154 T 21-04-2016 SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 Gene3D G3DSA:3.20.20.140 138 465 2.5E-154 T 21-04-2016 SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 Pfam PF02614 Glucuronate isomerase 1 464 2.5E-216 T 21-04-2016 IPR003766 Uronate isomerase GO:0006064|GO:0008880 KEGG: 00040+5.3.1.12|MetaCyc: PWY-7247|MetaCyc: PWY-7248|UniPathway: UPA00246 SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 Hamap MF_00675 Uronate isomerase [uxaC]. 2 466 48.769 T 21-04-2016 IPR003766 Uronate isomerase GO:0006064|GO:0008880 KEGG: 00040+5.3.1.12|MetaCyc: PWY-7247|MetaCyc: PWY-7248|UniPathway: UPA00246 SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 SUPERFAMILY SSF51556 2 465 9.52E-184 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 PANTHER PTHR30068 2 468 3.8E-248 T 21-04-2016 SPH21_RS14390 f9e54d411196555f22c391e216b033ad 470 PANTHER PTHR30068:SF4 2 468 3.8E-248 T 21-04-2016 SPH21_RS02765 d5f241aa805b64ca615ba0aed6077621 300 Pfam PF00781 Diacylglycerol kinase catalytic domain 8 125 1.9E-19 T 21-04-2016 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SPH21_RS02765 d5f241aa805b64ca615ba0aed6077621 300 Gene3D G3DSA:3.40.50.10330 58 128 1.0E-4 T 21-04-2016 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SPH21_RS02765 d5f241aa805b64ca615ba0aed6077621 300 SMART SM00046 8 128 1.5E-6 T 21-04-2016 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SPH21_RS02765 d5f241aa805b64ca615ba0aed6077621 300 PANTHER PTHR12358 49 282 5.6E-20 T 21-04-2016 SPH21_RS02765 d5f241aa805b64ca615ba0aed6077621 300 SUPERFAMILY SSF111331 8 293 5.36E-53 T 21-04-2016 IPR016064 NAD kinase/diacylglycerol kinase-like domain SPH21_RS17780 44734ea0a065a14e342776f3aa7ccaad 210 Pfam PF13605 Domain of unknown function (DUF4141) 5 57 9.0E-25 T 21-04-2016 IPR025415 Protein of unknown function DUF4141 SPH21_RS17780 44734ea0a065a14e342776f3aa7ccaad 210 Gene3D G3DSA:3.40.50.150 19 40 3.2E-4 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17780 44734ea0a065a14e342776f3aa7ccaad 210 Gene3D G3DSA:3.40.50.150 112 180 3.2E-4 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS22115 25b780cf83f0354ba1d113c9143e9bc0 189 SUPERFAMILY SSF55811 12 180 1.76E-24 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS22115 25b780cf83f0354ba1d113c9143e9bc0 189 PANTHER PTHR11839 4 183 2.6E-19 T 21-04-2016 SPH21_RS22115 25b780cf83f0354ba1d113c9143e9bc0 189 PANTHER PTHR11839:SF9 4 183 2.6E-19 T 21-04-2016 SPH21_RS22115 25b780cf83f0354ba1d113c9143e9bc0 189 Pfam PF00293 NUDIX domain 47 113 5.3E-8 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS22115 25b780cf83f0354ba1d113c9143e9bc0 189 Gene3D G3DSA:3.90.79.10 7 182 8.7E-30 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 Gene3D G3DSA:3.90.170.10 266 423 1.4E-63 T 21-04-2016 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 PANTHER PTHR11846 2 424 3.9E-206 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 ProSitePatterns PS00513 Adenylosuccinate synthetase active site. 134 145 - T 21-04-2016 IPR033128 Adenylosuccinate synthase, active site KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|UniPathway: UPA00075 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 ProSitePatterns PS01266 Adenylosuccinate synthetase GTP-binding site. 10 17 - T 21-04-2016 IPR018220 Adenylosuccinate synthase, GTP-binding site GO:0005525 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 Gene3D G3DSA:1.10.300.10 104 193 2.9E-26 T 21-04-2016 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 SMART SM00788 3 422 2.3E-230 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 Hamap MF_00011 Adenylosuccinate synthetase [purA]. 1 424 168.07 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 SUPERFAMILY SSF52540 1 423 1.91E-150 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 Pfam PF00709 Adenylosuccinate synthetase 5 420 1.6E-165 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 TIGRFAM TIGR00184 purA: adenylosuccinate synthase 5 423 3.5E-150 T 21-04-2016 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: REACT_1698|UniPathway: UPA00075 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 Gene3D G3DSA:3.40.440.10 194 265 1.8E-64 T 21-04-2016 SPH21_RS14900 33e7197b906f3a06b5955d008c3e53b2 424 Gene3D G3DSA:3.40.440.10 1 93 1.8E-64 T 21-04-2016 SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 SUPERFAMILY SSF51419 41 315 6.35E-36 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 Gene3D G3DSA:3.20.20.10 54 298 3.5E-28 T 21-04-2016 IPR029066 PLP-binding barrel SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 Gene3D G3DSA:2.40.37.10 299 438 9.6E-16 T 21-04-2016 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 319 432 4.5E-14 T 21-04-2016 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 68 313 1.1E-15 T 21-04-2016 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 Reactome: REACT_13 SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 PANTHER PTHR11482 23 462 3.4E-41 T 21-04-2016 SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 PANTHER PTHR11482:SF36 23 462 3.4E-41 T 21-04-2016 IPR002985 Arginine decarboxylase GO:0006527|GO:0008295|GO:0008792 KEGG: 00330+4.1.1.19|MetaCyc: PWY-40|MetaCyc: PWY-43|MetaCyc: PWY-6305|MetaCyc: PWY-6834 SPH21_RS14955 8f702e8e8d78e425d06da3c02a5f839a 463 SUPERFAMILY SSF50621 285 439 2.93E-22 T 21-04-2016 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 Reactome: REACT_13 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 Pfam PF00072 Response regulator receiver domain 6 117 2.0E-31 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 SUPERFAMILY SSF52172 3 135 5.27E-37 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 Pfam PF00196 Bacterial regulatory proteins, luxR family 163 216 9.9E-19 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 PANTHER PTHR26402 4 220 1.5E-62 T 21-04-2016 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 Gene3D G3DSA:3.40.50.2300 1 167 1.0E-38 T 21-04-2016 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 SMART SM00448 4 117 2.7E-35 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 SUPERFAMILY SSF46894 156 223 2.35E-19 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 PANTHER PTHR26402:SF458 4 220 1.5E-62 T 21-04-2016 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 SMART SM00421 160 217 6.0E-20 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 Gene3D G3DSA:1.10.10.10 168 222 1.0E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 163 177 5.0E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 193 205 5.0E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS18645 b6981a5cf5e0f43e480efda9b72ac802 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 177 193 5.0E-12 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS24130 79f71f91dff22c47461a06bb9333832c 317 Pfam PF14376 Haem-binding domain 34 141 1.8E-34 T 21-04-2016 IPR025992 Haem-binding domain SPH21_RS24130 79f71f91dff22c47461a06bb9333832c 317 Pfam PF16694 Cytochrome P460 185 306 6.2E-32 T 21-04-2016 IPR032033 Cytochrome P460 SPH21_RS24130 79f71f91dff22c47461a06bb9333832c 317 SMART SM01235 13 145 6.0E-42 T 21-04-2016 IPR025992 Haem-binding domain SPH21_RS25550 0e83f93f734d6f99155835758460e0d9 178 Pfam PF03653 Uncharacterised protein family (UPF0093) 1 145 1.4E-42 T 21-04-2016 IPR005265 Uncharacterised protein family UPF0093 SPH21_RS25550 0e83f93f734d6f99155835758460e0d9 178 PANTHER PTHR40255 1 175 5.1E-43 T 21-04-2016 SPH21_RS25550 0e83f93f734d6f99155835758460e0d9 178 PIRSF PIRSF004638 1 149 1.6E-45 T 21-04-2016 IPR005265 Uncharacterised protein family UPF0093 SPH21_RS24630 c34d1fa73d04e15f9583ba50a00fb232 275 PANTHER PTHR10366 7 263 5.4E-53 T 21-04-2016 SPH21_RS24630 c34d1fa73d04e15f9583ba50a00fb232 275 SUPERFAMILY SSF51735 7 263 7.11E-56 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24630 c34d1fa73d04e15f9583ba50a00fb232 275 Gene3D G3DSA:3.40.50.720 7 233 7.2E-47 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS24630 c34d1fa73d04e15f9583ba50a00fb232 275 Pfam PF01370 NAD dependent epimerase/dehydratase family 8 180 1.1E-27 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 Gene3D G3DSA:3.40.50.980 26 169 5.8E-18 T 21-04-2016 SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 Gene3D G3DSA:1.10.1200.10 562 641 6.9E-15 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 ProSitePatterns PS00455 Putative AMP-binding domain signature. 164 175 - T 21-04-2016 IPR020845 AMP-binding, conserved site SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 SUPERFAMILY SSF47336 570 639 5.37E-12 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 Pfam PF00550 Phosphopantetheine attachment site 586 639 2.7E-10 T 21-04-2016 IPR009081 Phosphopantetheine binding ACP domain SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 Gene3D G3DSA:3.40.50.980 170 335 5.3E-34 T 21-04-2016 SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 Gene3D G3DSA:3.30.300.30 439 542 7.9E-9 T 21-04-2016 SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 SUPERFAMILY SSF56801 23 547 1.96E-86 T 21-04-2016 SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 Pfam PF00501 AMP-binding enzyme 12 445 1.8E-61 T 21-04-2016 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 PANTHER PTHR22754 131 552 6.0E-72 T 21-04-2016 SPH21_RS06185 1b95d6e5aa60d5c0e5037a41f000b8be 643 Gene3D G3DSA:2.30.38.10 367 438 7.2E-18 T 21-04-2016 SPH21_RS05790 7af842e14e8621d696cf90066d02d695 794 Pfam PF12704 MacB-like periplasmic core domain 20 236 7.0E-18 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05790 7af842e14e8621d696cf90066d02d695 794 PANTHER PTHR30572 401 794 8.6E-95 T 21-04-2016 SPH21_RS05790 7af842e14e8621d696cf90066d02d695 794 PANTHER PTHR30572 9 355 8.6E-95 T 21-04-2016 SPH21_RS05790 7af842e14e8621d696cf90066d02d695 794 PANTHER PTHR30572:SF4 401 794 8.6E-95 T 21-04-2016 SPH21_RS05790 7af842e14e8621d696cf90066d02d695 794 PANTHER PTHR30572:SF4 9 355 8.6E-95 T 21-04-2016 SPH21_RS05790 7af842e14e8621d696cf90066d02d695 794 Pfam PF02687 FtsX-like permease family 675 782 2.9E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05790 7af842e14e8621d696cf90066d02d695 794 Pfam PF02687 FtsX-like permease family 289 404 2.5E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05860 d8c7521483f535ffc123620251548375 402 PANTHER PTHR23501 1 380 2.6E-117 T 21-04-2016 SPH21_RS05860 d8c7521483f535ffc123620251548375 402 PANTHER PTHR23501:SF4 1 380 2.6E-117 T 21-04-2016 SPH21_RS05860 d8c7521483f535ffc123620251548375 402 Gene3D G3DSA:1.20.1250.20 3 180 9.6E-26 T 21-04-2016 SPH21_RS05860 d8c7521483f535ffc123620251548375 402 Gene3D G3DSA:1.20.1250.20 197 380 3.2E-17 T 21-04-2016 SPH21_RS05860 d8c7521483f535ffc123620251548375 402 Pfam PF07690 Major Facilitator Superfamily 10 316 7.9E-31 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS05860 d8c7521483f535ffc123620251548375 402 SUPERFAMILY SSF103473 3 380 6.67E-57 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 PRINTS PR00741 Glycosyl hydrolase family 29 signature 124 140 1.0E-11 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 PRINTS PR00741 Glycosyl hydrolase family 29 signature 328 349 1.0E-11 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 PRINTS PR00741 Glycosyl hydrolase family 29 signature 361 383 1.0E-11 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 SUPERFAMILY SSF51445 43 378 2.65E-86 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 Pfam PF01120 Alpha-L-fucosidase 39 375 4.1E-82 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 Gene3D G3DSA:3.20.20.80 44 378 3.6E-95 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 PANTHER PTHR10030 214 416 7.9E-62 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 PANTHER PTHR10030 50 194 7.9E-62 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 SMART SM00812 34 418 2.2E-107 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14260 fd226ae6bf4038f86e33fd8bf57e088c 611 Gene3D G3DSA:2.60.40.1180 394 465 1.1E-5 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS09865 d48e6fe50d43108abfc2be546002a8e9 547 ProSitePatterns PS00456 Sodium:solute symporter family signature 1. 148 173 - T 21-04-2016 IPR018212 Sodium/solute symporter, conserved site GO:0005215|GO:0006810|GO:0016020 SPH21_RS09865 d48e6fe50d43108abfc2be546002a8e9 547 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 34 422 1.0E-57 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS09865 d48e6fe50d43108abfc2be546002a8e9 547 PANTHER PTHR11819 2 434 4.9E-80 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS09865 d48e6fe50d43108abfc2be546002a8e9 547 Pfam PF00474 Sodium:solute symporter family 34 419 1.7E-42 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS26040 25e43e8cb2f435c962f29884f857355b 378 Pfam PF01841 Transglutaminase-like superfamily 160 266 1.3E-4 T 21-04-2016 IPR002931 Transglutaminase-like SPH21_RS26040 25e43e8cb2f435c962f29884f857355b 378 SUPERFAMILY SSF54001 161 290 4.25E-10 T 21-04-2016 SPH21_RS14580 db7e95ccc576f8f8a54b724c5572fb55 227 Pfam PF14123 Domain of unknown function (DUF4290) 4 175 4.4E-74 T 21-04-2016 IPR025632 Protein of unknown function DUF4290 SPH21_RS17795 c03493344a903af590599ac9976ac1e2 101 Pfam PF13572 Domain of unknown function (DUF4134) 10 100 3.5E-38 T 21-04-2016 IPR025408 Protein of unknown function DUF4134 SPH21_RS07450 d8c61e033d846b6650d9d07d4a99851b 436 SUPERFAMILY SSF51905 29 67 3.98E-5 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS07450 d8c61e033d846b6650d9d07d4a99851b 436 SUPERFAMILY SSF51905 121 167 3.98E-5 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS07450 d8c61e033d846b6650d9d07d4a99851b 436 Pfam PF12831 FAD dependent oxidoreductase 31 174 1.2E-11 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS07450 d8c61e033d846b6650d9d07d4a99851b 436 Gene3D G3DSA:3.50.50.60 29 182 5.9E-7 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 TIGRFAM TIGR03654 L6_bact: ribosomal protein uL6 2 181 2.3E-70 T 21-04-2016 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 PANTHER PTHR11655:SF14 1 184 8.2E-82 T 21-04-2016 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 PIRSF PIRSF002162 1 182 1.3E-47 T 21-04-2016 IPR000702 Ribosomal protein L6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 PANTHER PTHR11655 1 184 8.2E-82 T 21-04-2016 IPR000702 Ribosomal protein L6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 ProSitePatterns PS00525 Ribosomal protein L6 signature 1. 159 167 - T 21-04-2016 IPR002358 Ribosomal protein L6, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 Gene3D G3DSA:3.90.930.12 2 83 3.2E-33 T 21-04-2016 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 Pfam PF00347 Ribosomal protein L6 11 83 1.1E-22 T 21-04-2016 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 Pfam PF00347 Ribosomal protein L6 91 168 1.7E-16 T 21-04-2016 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 Hamap MF_01365_B 50S ribosomal protein L6 [rplF]. 1 181 35.745 T 21-04-2016 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 SUPERFAMILY SSF56053 84 181 1.44E-30 T 21-04-2016 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 PRINTS PR00059 Ribosomal protein L6 signature 72 97 9.7E-24 T 21-04-2016 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 PRINTS PR00059 Ribosomal protein L6 signature 146 167 9.7E-24 T 21-04-2016 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 Gene3D G3DSA:3.90.930.12 85 182 1.3E-33 T 21-04-2016 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS08570 673b10fda9e09a38bef752e1e20efffd 184 SUPERFAMILY SSF56053 1 83 4.71E-27 T 21-04-2016 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS23475 33c0cf29ac9397d9edfcccdd6d258b25 509 SUPERFAMILY SSF48452 26 507 2.66E-132 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23475 33c0cf29ac9397d9edfcccdd6d258b25 509 Pfam PF14322 Starch-binding associating with outer membrane 29 225 4.5E-28 T 21-04-2016 SPH21_RS23475 33c0cf29ac9397d9edfcccdd6d258b25 509 Pfam PF07980 SusD family 280 507 4.8E-51 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23475 33c0cf29ac9397d9edfcccdd6d258b25 509 Gene3D G3DSA:1.25.40.10 205 299 6.8E-42 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23475 33c0cf29ac9397d9edfcccdd6d258b25 509 Gene3D G3DSA:1.25.40.10 350 444 6.8E-42 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 Pfam PF02311 AraC-like ligand binding domain 40 115 1.3E-4 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 Pfam PF12833 Helix-turn-helix domain 203 281 1.8E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 PANTHER PTHR11019 38 282 1.7E-37 T 21-04-2016 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 SUPERFAMILY SSF46689 236 282 3.49E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 PANTHER PTHR11019:SF45 38 282 1.7E-37 T 21-04-2016 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 SMART SM00342 197 280 2.8E-13 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 SUPERFAMILY SSF51215 40 107 1.57E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21495 48f7cbd1985a3ee1744122e49abad028 285 Gene3D G3DSA:1.10.10.60 236 283 5.1E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 Gene3D G3DSA:2.40.50.100 55 85 1.6E-19 T 21-04-2016 SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 Gene3D G3DSA:2.40.50.100 216 249 1.6E-19 T 21-04-2016 SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 PANTHER PTHR30386 12 344 1.5E-78 T 21-04-2016 SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 SUPERFAMILY SSF111369 54 107 2.09E-10 T 21-04-2016 SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 Pfam PF13533 Biotin-lipoyl like 54 98 1.7E-10 T 21-04-2016 SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 PANTHER PTHR30386:SF7 12 344 1.5E-78 T 21-04-2016 SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 164 293 1.7E-15 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS08705 9d4e795b1b7cb9a0476f8fa24467e051 348 SUPERFAMILY SSF111369 190 269 3.79E-10 T 21-04-2016 SPH21_RS11605 7d502e62df8059137fac278822287e7e 122 SUPERFAMILY SSF54995 1 97 1.57E-31 T 21-04-2016 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS11605 7d502e62df8059137fac278822287e7e 122 Pfam PF01250 Ribosomal protein S6 3 91 6.6E-29 T 21-04-2016 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS11605 7d502e62df8059137fac278822287e7e 122 PANTHER PTHR21011 1 94 2.4E-27 T 21-04-2016 SPH21_RS11605 7d502e62df8059137fac278822287e7e 122 Gene3D G3DSA:3.30.70.60 1 98 1.5E-32 T 21-04-2016 IPR014717 Translation elongation factor EF1B/ribosomal protein S6 SPH21_RS11605 7d502e62df8059137fac278822287e7e 122 TIGRFAM TIGR00166 S6: ribosomal protein bS6 1 94 3.1E-24 T 21-04-2016 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS11605 7d502e62df8059137fac278822287e7e 122 Hamap MF_00360 30S ribosomal protein S6 [rpsF]. 1 95 19.341 T 21-04-2016 IPR020814 Ribosomal protein S6, plastid/chloroplast GO:0003735|GO:0005840|GO:0006412|GO:0019843 SPH21_RS12505 2f9f2fae65082e77b5ae335a0b87ae42 374 PANTHER PTHR22916 46 358 1.0E-25 T 21-04-2016 SPH21_RS12505 2f9f2fae65082e77b5ae335a0b87ae42 374 SUPERFAMILY SSF53448 44 321 2.17E-36 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12505 2f9f2fae65082e77b5ae335a0b87ae42 374 Pfam PF00535 Glycosyl transferase family 2 49 185 1.2E-20 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS12505 2f9f2fae65082e77b5ae335a0b87ae42 374 Gene3D G3DSA:3.90.550.10 47 288 1.2E-29 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS24010 58f287645db03546af784673105935bd 266 PANTHER PTHR11019 15 258 7.8E-17 T 21-04-2016 SPH21_RS24010 58f287645db03546af784673105935bd 266 Gene3D G3DSA:1.10.10.60 168 213 9.1E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24010 58f287645db03546af784673105935bd 266 SUPERFAMILY SSF46689 214 262 5.82E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24010 58f287645db03546af784673105935bd 266 SUPERFAMILY SSF51215 19 117 3.4E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24010 58f287645db03546af784673105935bd 266 Gene3D G3DSA:1.10.10.60 214 262 4.4E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24010 58f287645db03546af784673105935bd 266 Gene3D G3DSA:2.60.120.280 19 96 2.0E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24010 58f287645db03546af784673105935bd 266 Pfam PF02311 AraC-like ligand binding domain 23 127 5.6E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS24010 58f287645db03546af784673105935bd 266 SMART SM00342 177 260 5.3E-12 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24010 58f287645db03546af784673105935bd 266 Pfam PF12833 Helix-turn-helix domain 187 261 9.7E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 SUPERFAMILY SSF49464 23 100 1.83E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 Gene3D G3DSA:2.40.170.20 236 745 8.3E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 Gene3D G3DSA:2.170.130.10 104 219 2.5E-9 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 PANTHER PTHR30069:SF1 22 644 3.4E-36 T 21-04-2016 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 Pfam PF13715 CarboxypepD_reg-like domain 25 109 3.6E-17 T 21-04-2016 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 Pfam PF07715 TonB-dependent Receptor Plug Domain 142 220 4.6E-11 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 SUPERFAMILY SSF56935 105 461 1.47E-68 T 21-04-2016 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 SUPERFAMILY SSF56935 490 772 1.47E-68 T 21-04-2016 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 PANTHER PTHR30069 22 644 3.4E-36 T 21-04-2016 SPH21_RS23725 2301775f61cf7a1e1ebf1b8e42ec3053 774 Gene3D G3DSA:2.60.40.1120 24 100 4.7E-16 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS00205 53b0187742caf1f191c40f0901579406 78 Pfam PF08507 COPI associated protein 1 76 1.0E-5 T 21-04-2016 IPR013714 Golgi apparatus membrane protein TVP15 SPH21_RS14815 c5092410e0ef66b05e9d308b59b03702 314 Pfam PF13585 C-terminal domain of CHU protein family 226 307 1.3E-27 T 21-04-2016 SPH21_RS14815 c5092410e0ef66b05e9d308b59b03702 314 TIGRFAM TIGR04131 Bac_Flav_CTERM: gliding motility-associated C-terminal domain 226 308 2.8E-16 T 21-04-2016 IPR026341 Gliding motility-associated, C-terminal domain SPH21_RS14815 c5092410e0ef66b05e9d308b59b03702 314 Gene3D G3DSA:2.60.40.10 24 92 1.7E-4 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS14815 c5092410e0ef66b05e9d308b59b03702 314 SUPERFAMILY SSF48726 24 93 2.64E-6 T 21-04-2016 IPR007110 Immunoglobulin-like domain GO:0005515 SPH21_RS14815 c5092410e0ef66b05e9d308b59b03702 314 TIGRFAM TIGR01451 B_ant_repeat: conserved repeat domain 107 150 2.8E-10 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS14815 c5092410e0ef66b05e9d308b59b03702 314 Pfam PF01345 Domain of unknown function DUF11 101 150 1.2E-9 T 21-04-2016 IPR001434 Domain of unknown function DUF11 SPH21_RS22190 8cfb3c3f94f7cba9f570b75cfac0b83a 197 Pfam PF09335 SNARE associated Golgi protein 33 159 9.1E-16 T 21-04-2016 IPR032816 SNARE associated Golgi protein SPH21_RS22190 8cfb3c3f94f7cba9f570b75cfac0b83a 197 PANTHER PTHR30353 1 197 1.0E-40 T 21-04-2016 IPR032818 DedA family SPH21_RS22190 8cfb3c3f94f7cba9f570b75cfac0b83a 197 PANTHER PTHR30353:SF0 1 197 1.0E-40 T 21-04-2016 SPH21_RS16315 d556f3b3602818e94bfc37c36fcc0d7a 260 PANTHER PTHR23088:SF28 1 253 2.1E-82 T 21-04-2016 SPH21_RS16315 d556f3b3602818e94bfc37c36fcc0d7a 260 SUPERFAMILY SSF56317 1 251 9.94E-63 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS16315 d556f3b3602818e94bfc37c36fcc0d7a 260 Pfam PF00795 Carbon-nitrogen hydrolase 6 234 3.7E-34 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS16315 d556f3b3602818e94bfc37c36fcc0d7a 260 Gene3D G3DSA:3.60.110.10 1 253 4.6E-62 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS16315 d556f3b3602818e94bfc37c36fcc0d7a 260 PANTHER PTHR23088 1 253 2.1E-82 T 21-04-2016 SPH21_RS15920 2acc3b08b40dd20ab532adaf0d40e916 225 Pfam PF13568 Outer membrane protein beta-barrel domain 31 201 1.4E-16 T 21-04-2016 IPR025665 Outer membrane protein beta-barrel domain SPH21_RS15920 2acc3b08b40dd20ab532adaf0d40e916 225 Gene3D G3DSA:2.40.160.20 136 223 1.6E-4 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 SUPERFAMILY SSF51445 41 356 2.38E-95 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 Gene3D G3DSA:3.20.20.80 39 356 2.6E-98 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 PANTHER PTHR10030 49 427 2.4E-69 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 SMART SM00812 31 396 1.3E-118 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 PRINTS PR00741 Glycosyl hydrolase family 29 signature 123 139 2.8E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 PRINTS PR00741 Glycosyl hydrolase family 29 signature 169 188 2.8E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 PRINTS PR00741 Glycosyl hydrolase family 29 signature 306 327 2.8E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 PRINTS PR00741 Glycosyl hydrolase family 29 signature 339 361 2.8E-16 T 21-04-2016 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SPH21_RS14220 943f30fc7a5e32af515f577ceb9a35a8 604 Pfam PF01120 Alpha-L-fucosidase 28 353 9.4E-97 T 21-04-2016 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SPH21_RS04275 4341857644f2d96e3c16100b8b17c02c 210 Pfam PF01048 Phosphorylase superfamily 37 95 5.4E-8 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS04275 4341857644f2d96e3c16100b8b17c02c 210 Pfam PF01048 Phosphorylase superfamily 137 182 4.9E-6 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS04275 4341857644f2d96e3c16100b8b17c02c 210 SUPERFAMILY SSF53167 35 187 7.72E-31 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS04275 4341857644f2d96e3c16100b8b17c02c 210 Gene3D G3DSA:3.40.50.1580 32 191 8.1E-31 T 21-04-2016 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SPH21_RS23830 9844537a42301053795a45b90a9433a1 385 Gene3D G3DSA:2.170.16.10 250 382 5.8E-19 T 21-04-2016 IPR028992 Hedgehog/Intein (Hint) domain SPH21_RS23830 9844537a42301053795a45b90a9433a1 385 SUPERFAMILY SSF51294 250 383 1.57E-20 T 21-04-2016 IPR028992 Hedgehog/Intein (Hint) domain SPH21_RS23830 9844537a42301053795a45b90a9433a1 385 TIGRFAM TIGR01443 intein_Cterm: intein C-terminal splicing region 360 382 7.4E-4 T 21-04-2016 IPR030934 Intein C-terminal splicing region SPH21_RS23830 9844537a42301053795a45b90a9433a1 385 SMART SM00306 248 342 1.1E-10 T 21-04-2016 IPR003587 Hint domain N-terminal SPH21_RS23830 9844537a42301053795a45b90a9433a1 385 Pfam PF07591 Pretoxin HINT domain 256 383 1.2E-12 T 21-04-2016 SPH21_RS09075 97e980240a0f53344f6176692b2079d4 250 SUPERFAMILY SSF89550 18 222 7.45E-13 T 21-04-2016 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 SPH21_RS09075 97e980240a0f53344f6176692b2079d4 250 PIRSF PIRSF016557 19 250 4.3E-51 T 21-04-2016 IPR016667 Capsular polysaccharide synthesis, CpsB/CapC GO:0004725|GO:0030145 UniPathway: UPA00934 SPH21_RS09075 97e980240a0f53344f6176692b2079d4 250 PANTHER PTHR39181 20 223 8.4E-52 T 21-04-2016 SPH21_RS09075 97e980240a0f53344f6176692b2079d4 250 PANTHER PTHR39181:SF1 20 223 8.4E-52 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 Gene3D G3DSA:3.40.50.880 10 196 6.8E-57 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 Pfam PF00117 Glutamine amidotransferase class-I 14 195 4.4E-43 T 21-04-2016 IPR017926 Glutamine amidotransferase Reactome: REACT_1698 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 SUPERFAMILY SSF52317 11 196 5.35E-49 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PANTHER PTHR11922:SF7 1 196 4.1E-72 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00097 Anthranilate synthase component II signature 82 93 2.2E-28 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00097 Anthranilate synthase component II signature 129 141 2.2E-28 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00097 Anthranilate synthase component II signature 55 64 2.2E-28 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00097 Anthranilate synthase component II signature 174 187 2.2E-28 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00097 Anthranilate synthase component II signature 12 26 2.2E-28 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00097 Anthranilate synthase component II signature 107 115 2.2E-28 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 TIGRFAM TIGR00566 trpG_papA: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase 12 196 6.0E-51 T 21-04-2016 IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain GO:0008152 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00096 Glutamine amidotransferase superfamily signature 82 93 4.0E-12 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00096 Glutamine amidotransferase superfamily signature 55 64 4.0E-12 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PRINTS PR00096 Glutamine amidotransferase superfamily signature 174 187 4.0E-12 T 21-04-2016 SPH21_RS07435 25364494876851781a51ec7eb373c53d 197 PANTHER PTHR11922 1 196 4.1E-72 T 21-04-2016 SPH21_RS00450 60d7604a0ca64eb6f2d6a38a1eda4238 451 SUPERFAMILY SSF48452 21 450 2.4E-59 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00450 60d7604a0ca64eb6f2d6a38a1eda4238 451 Pfam PF07980 SusD family 343 417 2.4E-9 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS00450 60d7604a0ca64eb6f2d6a38a1eda4238 451 Pfam PF14322 Starch-binding associating with outer membrane 26 230 6.3E-34 T 21-04-2016 SPH21_RS00450 60d7604a0ca64eb6f2d6a38a1eda4238 451 Gene3D G3DSA:1.25.40.10 214 402 9.9E-13 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 PANTHER PTHR10992 18 251 2.0E-35 T 21-04-2016 SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 SUPERFAMILY SSF53474 11 246 1.04E-28 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 PRINTS PR00111 Alpha/beta hydrolase fold signature 88 101 9.3E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 PRINTS PR00111 Alpha/beta hydrolase fold signature 43 58 9.3E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 PRINTS PR00111 Alpha/beta hydrolase fold signature 102 115 9.3E-5 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 PANTHER PTHR10992:SF810 18 251 2.0E-35 T 21-04-2016 SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 Pfam PF12697 Alpha/beta hydrolase family 19 242 1.7E-14 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS22805 3734ff95a6fe566a87e575c795e2ab17 251 Gene3D G3DSA:3.40.50.1820 16 248 3.8E-48 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS14295 720eee215e75991590b6165842b996b2 359 Gene3D G3DSA:3.20.20.140 1 357 6.7E-75 T 21-04-2016 SPH21_RS14295 720eee215e75991590b6165842b996b2 359 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 2 353 5.3E-46 T 21-04-2016 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533 SPH21_RS14295 720eee215e75991590b6165842b996b2 359 PANTHER PTHR10443 182 357 8.8E-32 T 21-04-2016 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533 SPH21_RS14295 720eee215e75991590b6165842b996b2 359 SUPERFAMILY SSF51556 1 356 5.99E-63 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 ProSitePatterns PS00397 Site-specific recombinases active site. 7 15 - T 21-04-2016 IPR006118 Recombinase, conserved site GO:0000150|GO:0006310 SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 Pfam PF07508 Recombinase 179 265 1.4E-10 T 21-04-2016 IPR011109 DNA-binding recombinase domain GO:0000150|GO:0003677 SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 PANTHER PTHR30461 1 428 1.4E-35 T 21-04-2016 SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 SMART SM00857 4 153 2.7E-35 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 Pfam PF00239 Resolvase, N terminal domain 4 153 1.2E-25 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 SUPERFAMILY SSF53041 4 153 1.31E-26 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 PANTHER PTHR30461:SF3 1 428 1.4E-35 T 21-04-2016 SPH21_RS00575 0c36e4ef36852c5f0e9e2e5a0a87d478 489 Gene3D G3DSA:3.40.50.1390 4 134 1.4E-22 T 21-04-2016 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SPH21_RS24280 add4cef5ddb1f69c1b2decf878493539 1224 Gene3D G3DSA:3.40.50.300 33 78 1.5E-4 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24280 add4cef5ddb1f69c1b2decf878493539 1224 SUPERFAMILY SSF52540 35 90 1.2E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS24280 add4cef5ddb1f69c1b2decf878493539 1224 SUPERFAMILY SSF52540 223 378 1.2E-6 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02640 03d9ba30502e385c1862c58ed5c2c8ed 779 Gene3D G3DSA:3.30.450.40 340 401 1.3E-7 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS02640 03d9ba30502e385c1862c58ed5c2c8ed 779 SUPERFAMILY SSF55781 348 402 3.93E-7 T 21-04-2016 IPR029016 GAF domain-like SPH21_RS19020 5e1987a94bd4c8ddbef812e8991292cd 355 PANTHER PTHR30160:SF7 8 301 7.7E-45 T 21-04-2016 SPH21_RS19020 5e1987a94bd4c8ddbef812e8991292cd 355 Gene3D G3DSA:3.40.50.2000 181 317 1.5E-31 T 21-04-2016 SPH21_RS19020 5e1987a94bd4c8ddbef812e8991292cd 355 Gene3D G3DSA:3.40.50.2000 8 164 3.1E-30 T 21-04-2016 SPH21_RS19020 5e1987a94bd4c8ddbef812e8991292cd 355 SUPERFAMILY SSF53756 8 352 6.28E-59 T 21-04-2016 SPH21_RS19020 5e1987a94bd4c8ddbef812e8991292cd 355 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase) 81 313 1.5E-26 T 21-04-2016 IPR002201 Glycosyl transferase, family 9 GO:0008152|GO:0016757 SPH21_RS19020 5e1987a94bd4c8ddbef812e8991292cd 355 PANTHER PTHR30160 8 301 7.7E-45 T 21-04-2016 SPH21_RS02295 f92b20564158e8519df9f37416cf7382 917 PANTHER PTHR36848:SF1 27 895 1.3E-168 T 21-04-2016 SPH21_RS02295 f92b20564158e8519df9f37416cf7382 917 PANTHER PTHR36848 27 895 1.3E-168 T 21-04-2016 SPH21_RS02295 f92b20564158e8519df9f37416cf7382 917 Pfam PF17132 alpha-L-rhamnosidase 32 151 1.2E-12 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS02295 f92b20564158e8519df9f37416cf7382 917 Pfam PF17132 alpha-L-rhamnosidase 173 491 2.1E-44 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS02295 f92b20564158e8519df9f37416cf7382 917 Pfam PF17132 alpha-L-rhamnosidase 521 701 8.1E-16 T 21-04-2016 IPR033400 Alpha-L-rhamnosidase RhaM SPH21_RS02295 f92b20564158e8519df9f37416cf7382 917 Gene3D G3DSA:2.60.120.260 755 885 1.8E-9 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS02295 f92b20564158e8519df9f37416cf7382 917 SUPERFAMILY SSF49785 756 916 2.21E-12 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS04610 82dc57c6df00d1875213759882e7d2ad 403 PANTHER PTHR30273:SF2 185 401 9.1E-60 T 21-04-2016 SPH21_RS04610 82dc57c6df00d1875213759882e7d2ad 403 PANTHER PTHR30273:SF2 1 126 9.1E-60 T 21-04-2016 SPH21_RS04610 82dc57c6df00d1875213759882e7d2ad 403 Pfam PF16344 Domain of unknown function (DUF4974) 298 389 1.1E-14 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS04610 82dc57c6df00d1875213759882e7d2ad 403 PANTHER PTHR30273 185 401 9.1E-60 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS04610 82dc57c6df00d1875213759882e7d2ad 403 PANTHER PTHR30273 1 126 9.1E-60 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS04610 82dc57c6df00d1875213759882e7d2ad 403 Pfam PF04773 FecR protein 184 277 2.6E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS16915 80b3c6f6078f57fbb6be786c33a99407 175 SMART SM00867 4 172 6.8E-61 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS16915 80b3c6f6078f57fbb6be786c33a99407 175 Gene3D G3DSA:2.40.128.110 3 174 1.7E-57 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS16915 80b3c6f6078f57fbb6be786c33a99407 175 SUPERFAMILY SSF101874 4 174 1.83E-53 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS16915 80b3c6f6078f57fbb6be786c33a99407 175 PANTHER PTHR34406 1 174 7.1E-54 T 21-04-2016 SPH21_RS16915 80b3c6f6078f57fbb6be786c33a99407 175 PANTHER PTHR34406:SF1 1 174 7.1E-54 T 21-04-2016 SPH21_RS16915 80b3c6f6078f57fbb6be786c33a99407 175 Pfam PF04264 YceI-like domain 5 169 1.7E-43 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS25955 85eee94b54d4adc17e3c144b9a72b12c 264 Gene3D G3DSA:1.10.530.10 93 242 9.6E-40 T 21-04-2016 SPH21_RS25955 85eee94b54d4adc17e3c144b9a72b12c 264 PANTHER PTHR21666 56 239 9.3E-40 T 21-04-2016 SPH21_RS25955 85eee94b54d4adc17e3c144b9a72b12c 264 Pfam PF01464 Transglycosylase SLT domain 114 210 5.6E-22 T 21-04-2016 IPR008258 Transglycosylase SLT domain 1 SPH21_RS25955 85eee94b54d4adc17e3c144b9a72b12c 264 SUPERFAMILY SSF53955 96 239 5.85E-32 T 21-04-2016 IPR023346 Lysozyme-like domain SPH21_RS25955 85eee94b54d4adc17e3c144b9a72b12c 264 PANTHER PTHR21666:SF182 56 239 9.3E-40 T 21-04-2016 SPH21_RS18660 8df9ea7061b9de06236db85d1602923e 138 SUPERFAMILY SSF50022 19 124 3.93E-37 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS18660 8df9ea7061b9de06236db85d1602923e 138 TIGRFAM TIGR02378 nirD_assim_sml: nitrite reductase [NAD(P)H], small subunit 20 123 2.3E-32 T 21-04-2016 IPR012748 Nitrite reductase [NAD(P)H] small subunit, NirD GO:0008942|GO:0042128|GO:0055114 SPH21_RS18660 8df9ea7061b9de06236db85d1602923e 138 Gene3D G3DSA:2.102.10.10 19 129 1.9E-39 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS18660 8df9ea7061b9de06236db85d1602923e 138 PANTHER PTHR21496 12 129 1.6E-12 T 21-04-2016 SPH21_RS18660 8df9ea7061b9de06236db85d1602923e 138 Pfam PF13806 Rieske-like [2Fe-2S] domain 19 122 1.0E-25 T 21-04-2016 IPR012748 Nitrite reductase [NAD(P)H] small subunit, NirD GO:0008942|GO:0042128|GO:0055114 SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 Gene3D G3DSA:3.40.50.720 8 236 6.0E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 Pfam PF00106 short chain dehydrogenase 12 199 1.1E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 2.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 2.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 2.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PANTHER PTHR24322:SF631 16 144 1.2E-44 T 21-04-2016 SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PANTHER PTHR24322:SF631 160 193 1.2E-44 T 21-04-2016 SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 SUPERFAMILY SSF51735 5 265 4.77E-62 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 1.0E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 1.0E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 182 199 1.0E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 1.0E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 1.0E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 1.0E-21 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PANTHER PTHR24322 16 144 1.2E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS18555 7abadabae18c81e4cfda48f648bd6a6c 321 PANTHER PTHR24322 160 193 1.2E-44 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS17970 62fbf3641536fb343d30d2c2431369a0 474 Pfam PF13101 Protein of unknown function (DUF3945) 357 384 0.084 T 21-04-2016 IPR025222 Protein of unknown function DUF3945 SPH21_RS17970 62fbf3641536fb343d30d2c2431369a0 474 Pfam PF13101 Protein of unknown function (DUF3945) 262 319 2.2E-23 T 21-04-2016 IPR025222 Protein of unknown function DUF3945 SPH21_RS17970 62fbf3641536fb343d30d2c2431369a0 474 Pfam PF13351 Protein of unknown function (DUF4099) 147 228 3.4E-26 T 21-04-2016 IPR025343 Protein of unknown function DUF4099 SPH21_RS11330 48aa53912e67e4afa0409dd876ea2dd7 521 Pfam PF00474 Sodium:solute symporter family 39 466 3.6E-43 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS11330 48aa53912e67e4afa0409dd876ea2dd7 521 PANTHER PTHR11819:SF163 337 479 5.8E-174 T 21-04-2016 SPH21_RS11330 48aa53912e67e4afa0409dd876ea2dd7 521 PANTHER PTHR11819:SF163 5 297 5.8E-174 T 21-04-2016 SPH21_RS11330 48aa53912e67e4afa0409dd876ea2dd7 521 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 38 466 9.6E-65 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS11330 48aa53912e67e4afa0409dd876ea2dd7 521 PANTHER PTHR11819 337 479 5.8E-174 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS11330 48aa53912e67e4afa0409dd876ea2dd7 521 PANTHER PTHR11819 5 297 5.8E-174 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS15685 ae555eee56973532497595b46976dd5c 133 SUPERFAMILY SSF55961 1 132 5.29E-12 T 21-04-2016 SPH21_RS15685 ae555eee56973532497595b46976dd5c 133 Gene3D G3DSA:3.30.530.20 8 120 2.5E-7 T 21-04-2016 IPR023393 START-like domain SPH21_RS19980 8cecef0d35822557e4fa011e6df2c902 163 SMART SM00855 4 117 0.003 T 21-04-2016 IPR013078 Histidine phosphatase superfamily, clade-1 SPH21_RS19980 8cecef0d35822557e4fa011e6df2c902 163 PANTHER PTHR23029 5 85 6.7E-15 T 21-04-2016 SPH21_RS19980 8cecef0d35822557e4fa011e6df2c902 163 Gene3D G3DSA:3.40.50.1240 1 161 2.0E-48 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS19980 8cecef0d35822557e4fa011e6df2c902 163 SUPERFAMILY SSF53254 1 161 6.48E-30 T 21-04-2016 IPR029033 Histidine phosphatase superfamily SPH21_RS19980 8cecef0d35822557e4fa011e6df2c902 163 PANTHER PTHR23029:SF1 5 85 6.7E-15 T 21-04-2016 SPH21_RS19980 8cecef0d35822557e4fa011e6df2c902 163 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 5 88 2.7E-13 T 21-04-2016 IPR013078 Histidine phosphatase superfamily, clade-1 SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 Gene3D G3DSA:3.40.50.300 148 294 5.8E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 Gene3D G3DSA:3.40.50.300 10 101 5.8E-54 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 Pfam PF12848 ABC transporter 237 314 7.3E-12 T 21-04-2016 IPR032781 ABC-transporter extension domain SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 ProSitePatterns PS00211 ABC transporters family signature. 170 184 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 TIGRFAM TIGR03719 ABC_ABC_ChvD: ATP-binding cassette protein, ChvD family 5 558 8.2E-290 T 21-04-2016 IPR022374 ABC transporter, ATP-binding protein, ChvD SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 Gene3D G3DSA:1.20.58.410 102 145 1.8E-5 T 21-04-2016 SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 PANTHER PTHR19211 4 560 0.0 T 21-04-2016 SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 Gene3D G3DSA:3.40.50.300 328 543 4.3E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 SUPERFAMILY SSF52540 12 243 1.78E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 SMART SM00382 355 533 2.2E-9 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 SMART SM00382 33 243 1.3E-10 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 PANTHER PTHR19211:SF7 4 560 0.0 T 21-04-2016 SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 Pfam PF00005 ABC transporter 347 480 4.6E-23 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 Pfam PF00005 ABC transporter 24 198 1.1E-26 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS02015 3a12b5d1603b280d286234f194d2d20d 560 SUPERFAMILY SSF52540 307 529 7.82E-46 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21650 cab2471ed7f357eabacfdcb151179a5f 303 SUPERFAMILY SSF46689 253 301 6.27E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21650 cab2471ed7f357eabacfdcb151179a5f 303 Pfam PF12833 Helix-turn-helix domain 221 299 2.4E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21650 cab2471ed7f357eabacfdcb151179a5f 303 PANTHER PTHR11019 50 303 1.4E-32 T 21-04-2016 SPH21_RS21650 cab2471ed7f357eabacfdcb151179a5f 303 Gene3D G3DSA:1.10.10.60 253 300 5.5E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21650 cab2471ed7f357eabacfdcb151179a5f 303 PANTHER PTHR11019:SF50 50 303 1.4E-32 T 21-04-2016 SPH21_RS21650 cab2471ed7f357eabacfdcb151179a5f 303 SMART SM00342 215 298 2.7E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23500 091423a8a558a4fcdde4aa9711baa5e0 284 PANTHER PTHR11019:SF80 16 283 1.0E-17 T 21-04-2016 SPH21_RS23500 091423a8a558a4fcdde4aa9711baa5e0 284 SUPERFAMILY SSF46689 239 283 1.0E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23500 091423a8a558a4fcdde4aa9711baa5e0 284 Gene3D G3DSA:2.60.120.280 39 163 6.2E-5 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS23500 091423a8a558a4fcdde4aa9711baa5e0 284 Pfam PF12833 Helix-turn-helix domain 206 283 2.5E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23500 091423a8a558a4fcdde4aa9711baa5e0 284 PANTHER PTHR11019 16 283 1.0E-17 T 21-04-2016 SPH21_RS23500 091423a8a558a4fcdde4aa9711baa5e0 284 SMART SM00342 199 283 4.5E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23500 091423a8a558a4fcdde4aa9711baa5e0 284 Gene3D G3DSA:1.10.10.60 238 283 5.6E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 PANTHER PTHR30069:SF2 1 339 9.1E-28 T 21-04-2016 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 PANTHER PTHR30069:SF2 765 788 9.1E-28 T 21-04-2016 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 Pfam PF13715 CarboxypepD_reg-like domain 29 113 3.0E-17 T 21-04-2016 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 PANTHER PTHR30069 1 339 9.1E-28 T 21-04-2016 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 PANTHER PTHR30069 765 788 9.1E-28 T 21-04-2016 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 Gene3D G3DSA:2.40.170.20 229 788 5.3E-38 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 SUPERFAMILY SSF49464 28 117 1.11E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 SUPERFAMILY SSF56935 109 788 2.82E-65 T 21-04-2016 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 Pfam PF07715 TonB-dependent Receptor Plug Domain 124 226 2.0E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 Gene3D G3DSA:2.60.40.1120 29 111 1.1E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS12315 ce387b8f4bee839472b8391a5e411041 793 Gene3D G3DSA:2.170.130.10 112 228 6.3E-26 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 TIGRFAM TIGR00078 nadC: nicotinate-nucleotide diphosphorylase (carboxylating) 10 278 3.0E-94 T 21-04-2016 IPR004393 Nicotinate-nucleotide pyrophosphorylase GO:0004514|GO:0019363 KEGG: 00760+2.4.2.19|MetaCyc: PWY-5316|MetaCyc: PWY-5653|MetaCyc: PWY-7342|UniPathway: UPA00253 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 Pfam PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 18 107 1.3E-22 T 21-04-2016 IPR022412 Quinolinate phosphoribosyl transferase, N-terminal GO:0016763 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 Gene3D G3DSA:3.90.1170.20 3 129 2.1E-46 T 21-04-2016 IPR022412 Quinolinate phosphoribosyl transferase, N-terminal GO:0016763 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 Gene3D G3DSA:3.20.20.70 130 269 7.8E-56 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 SUPERFAMILY SSF51690 109 278 2.12E-54 T 21-04-2016 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: REACT_11193|UniPathway: UPA00253 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 PANTHER PTHR32179 5 278 1.1E-118 T 21-04-2016 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 SUPERFAMILY SSF54675 6 108 6.67E-29 T 21-04-2016 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 Pfam PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 109 278 3.3E-58 T 21-04-2016 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: REACT_11193|UniPathway: UPA00253 SPH21_RS14880 8b3f7301d4dc7ff75fae5729e881e11e 283 PIRSF PIRSF006250 2 281 1.2E-87 T 21-04-2016 IPR027277 Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD SPH21_RS23675 13fea8fb23e1ca672d6f30ba5fbdf883 544 SUPERFAMILY SSF48452 28 544 7.59E-112 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23675 13fea8fb23e1ca672d6f30ba5fbdf883 544 Pfam PF14322 Starch-binding associating with outer membrane 110 229 3.8E-17 T 21-04-2016 SPH21_RS23675 13fea8fb23e1ca672d6f30ba5fbdf883 544 Pfam PF07980 SusD family 295 544 4.3E-45 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23675 13fea8fb23e1ca672d6f30ba5fbdf883 544 Gene3D G3DSA:1.25.40.10 211 310 2.1E-28 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23675 13fea8fb23e1ca672d6f30ba5fbdf883 544 Gene3D G3DSA:1.25.40.10 372 464 2.1E-28 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14340 d3c1f075698780704cf1c886e29c77ac 546 Gene3D G3DSA:2.115.10.20 42 321 2.3E-74 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS14340 d3c1f075698780704cf1c886e29c77ac 546 PANTHER PTHR22925 1 543 2.3E-182 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS14340 d3c1f075698780704cf1c886e29c77ac 546 PANTHER PTHR22925:SF34 1 543 2.3E-182 T 21-04-2016 SPH21_RS14340 d3c1f075698780704cf1c886e29c77ac 546 SUPERFAMILY SSF75005 43 318 7.07E-82 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS14340 d3c1f075698780704cf1c886e29c77ac 546 SUPERFAMILY SSF49899 344 545 2.02E-31 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS14340 d3c1f075698780704cf1c886e29c77ac 546 Gene3D G3DSA:2.60.120.200 346 545 6.1E-38 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS14340 d3c1f075698780704cf1c886e29c77ac 546 Pfam PF04616 Glycosyl hydrolases family 43 43 313 3.6E-69 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS26355 3beeeabc21b5884951f6bed601d6ed22 63 SUPERFAMILY SSF56954 2 55 8.63E-7 T 21-04-2016 SPH21_RS26225 fa7b2805b371cbd2e11038f1377d6dc1 93 Gene3D G3DSA:3.40.30.10 5 91 3.5E-7 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26225 fa7b2805b371cbd2e11038f1377d6dc1 93 SUPERFAMILY SSF52833 5 91 1.18E-6 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS26345 76c3da76e08bf58e746a419de0721b7b 441 SUPERFAMILY SSF103088 325 438 6.15E-30 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS26345 76c3da76e08bf58e746a419de0721b7b 441 Pfam PF00691 OmpA family 337 433 1.5E-19 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS26345 76c3da76e08bf58e746a419de0721b7b 441 PRINTS PR01021 OMPA domain signature 383 399 6.9E-11 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS26345 76c3da76e08bf58e746a419de0721b7b 441 PRINTS PR01021 OMPA domain signature 338 360 6.9E-11 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS26345 76c3da76e08bf58e746a419de0721b7b 441 PRINTS PR01021 OMPA domain signature 368 383 6.9E-11 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS26345 76c3da76e08bf58e746a419de0721b7b 441 PANTHER PTHR30128 336 438 2.3E-35 T 21-04-2016 SPH21_RS26345 76c3da76e08bf58e746a419de0721b7b 441 Gene3D G3DSA:3.30.1330.60 333 438 2.5E-33 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS22200 94052cec4e575f227bf7517b62ba7945 499 Gene3D G3DSA:3.40.30.10 372 490 2.4E-23 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS22200 94052cec4e575f227bf7517b62ba7945 499 SUPERFAMILY SSF52833 371 482 7.27E-17 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS22200 94052cec4e575f227bf7517b62ba7945 499 Pfam PF13905 Thioredoxin-like 376 475 3.8E-9 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS16685 00dfd36af22c3c0598ef661011dc6d62 162 Pfam PF14539 Domain of unknown function (DUF4442) 11 147 6.9E-9 T 21-04-2016 IPR027961 Protein of unknown function DUF4442 SPH21_RS16685 00dfd36af22c3c0598ef661011dc6d62 162 Gene3D G3DSA:3.10.129.10 4 150 2.2E-22 T 21-04-2016 IPR029069 HotDog domain SPH21_RS16685 00dfd36af22c3c0598ef661011dc6d62 162 SUPERFAMILY SSF54637 4 149 2.95E-14 T 21-04-2016 IPR029069 HotDog domain SPH21_RS17480 c90c2b384f5005d67a6ced7b7b5431e5 204 Pfam PF01712 Deoxynucleoside kinase 3 199 4.8E-59 T 21-04-2016 IPR031314 Deoxynucleoside kinase domain SPH21_RS17480 c90c2b384f5005d67a6ced7b7b5431e5 204 PIRSF PIRSF000705 1 203 7.4E-63 T 21-04-2016 IPR002624 Deoxynucleoside kinase GO:0005524|GO:0006139|GO:0019206 SPH21_RS17480 c90c2b384f5005d67a6ced7b7b5431e5 204 Gene3D G3DSA:3.40.50.300 1 198 1.0E-62 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17480 c90c2b384f5005d67a6ced7b7b5431e5 204 PANTHER PTHR10513 1 196 3.7E-70 T 21-04-2016 SPH21_RS17480 c90c2b384f5005d67a6ced7b7b5431e5 204 SUPERFAMILY SSF52540 1 200 6.99E-49 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17480 c90c2b384f5005d67a6ced7b7b5431e5 204 PANTHER PTHR10513:SF17 1 196 3.7E-70 T 21-04-2016 SPH21_RS26165 f7e5a65d8becb9367a99a97fcca34b31 241 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 156 190 3.8E-4 T 21-04-2016 IPR001451 Hexapeptide repeat SPH21_RS26165 f7e5a65d8becb9367a99a97fcca34b31 241 PANTHER PTHR23416 77 236 1.9E-39 T 21-04-2016 SPH21_RS26165 f7e5a65d8becb9367a99a97fcca34b31 241 SUPERFAMILY SSF51161 78 238 3.85E-39 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS26165 f7e5a65d8becb9367a99a97fcca34b31 241 PANTHER PTHR23416:SF69 77 236 1.9E-39 T 21-04-2016 SPH21_RS26165 f7e5a65d8becb9367a99a97fcca34b31 241 Gene3D G3DSA:2.160.10.10 65 240 1.8E-46 T 21-04-2016 SPH21_RS09340 434a3ae04d1bab08493aa990cf71eb74 280 PANTHER PTHR40446:SF1 113 279 1.9E-14 T 21-04-2016 SPH21_RS09340 434a3ae04d1bab08493aa990cf71eb74 280 Pfam PF09992 Phosphodiester glycosidase 95 278 2.2E-39 T 21-04-2016 IPR018711 Phosphodiester glycosidase SPH21_RS09340 434a3ae04d1bab08493aa990cf71eb74 280 PANTHER PTHR40446 113 279 1.9E-14 T 21-04-2016 SPH21_RS23405 bdf3b2dba1879b94801fadd146c0ec88 596 Pfam PF07980 SusD family 284 595 1.0E-46 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23405 bdf3b2dba1879b94801fadd146c0ec88 596 SUPERFAMILY SSF48452 14 497 1.26E-97 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23405 bdf3b2dba1879b94801fadd146c0ec88 596 SUPERFAMILY SSF48452 563 595 1.26E-97 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23405 bdf3b2dba1879b94801fadd146c0ec88 596 Gene3D G3DSA:1.25.40.10 187 303 1.7E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23405 bdf3b2dba1879b94801fadd146c0ec88 596 Gene3D G3DSA:1.25.40.10 366 470 1.7E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23405 bdf3b2dba1879b94801fadd146c0ec88 596 Pfam PF14322 Starch-binding associating with outer membrane 18 205 1.1E-7 T 21-04-2016 SPH21_RS22110 d135ad2e1eb980ea9b039d0081d8b6b4 122 Pfam PF00072 Response regulator receiver domain 8 115 7.0E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22110 d135ad2e1eb980ea9b039d0081d8b6b4 122 PANTHER PTHR26402 5 116 2.0E-16 T 21-04-2016 SPH21_RS22110 d135ad2e1eb980ea9b039d0081d8b6b4 122 SUPERFAMILY SSF52172 3 119 1.57E-24 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS22110 d135ad2e1eb980ea9b039d0081d8b6b4 122 SMART SM00448 5 115 3.6E-14 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22110 d135ad2e1eb980ea9b039d0081d8b6b4 122 Gene3D G3DSA:3.40.50.2300 3 116 1.5E-20 T 21-04-2016 SPH21_RS22110 d135ad2e1eb980ea9b039d0081d8b6b4 122 PANTHER PTHR26402:SF117 5 116 2.0E-16 T 21-04-2016 SPH21_RS22930 55d4c8747eb86e504c51a30f14e2739e 379 Gene3D G3DSA:3.90.1150.10 244 378 2.7E-52 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS22930 55d4c8747eb86e504c51a30f14e2739e 379 PANTHER PTHR11808:SF15 1 378 7.2E-211 T 21-04-2016 SPH21_RS22930 55d4c8747eb86e504c51a30f14e2739e 379 SUPERFAMILY SSF53383 5 378 2.39E-125 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS22930 55d4c8747eb86e504c51a30f14e2739e 379 Gene3D G3DSA:3.40.640.10 1 243 1.4E-101 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS22930 55d4c8747eb86e504c51a30f14e2739e 379 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 4 378 1.8E-157 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS22930 55d4c8747eb86e504c51a30f14e2739e 379 PIRSF PIRSF001434 1 379 7.2E-150 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS22930 55d4c8747eb86e504c51a30f14e2739e 379 PANTHER PTHR11808 1 378 7.2E-211 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 Gene3D G3DSA:3.40.50.2300 267 339 7.4E-8 T 21-04-2016 SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 Pfam PF00392 Bacterial regulatory proteins, gntR family 19 81 4.3E-9 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 SUPERFAMILY SSF46785 17 91 1.49E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 Pfam PF13377 Periplasmic binding protein-like domain 208 339 3.8E-6 T 21-04-2016 SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 PANTHER PTHR38445:SF1 1 292 1.7E-16 T 21-04-2016 SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 Gene3D G3DSA:1.10.10.10 15 82 3.9E-16 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 SMART SM00345 22 81 1.5E-8 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 PANTHER PTHR38445 1 292 1.7E-16 T 21-04-2016 SPH21_RS09820 f4655eeba7d4ea9eb536c9df8416fa7a 340 SUPERFAMILY SSF53822 102 339 5.83E-17 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 PANTHER PTHR11731:SF90 339 736 3.7E-84 T 21-04-2016 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 PANTHER PTHR11731:SF90 1 286 3.7E-84 T 21-04-2016 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 Pfam PF07676 WD40-like Beta Propeller Repeat 152 171 5.3E-4 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 Pfam PF07676 WD40-like Beta Propeller Repeat 100 135 0.0019 T 21-04-2016 IPR011659 WD40-like Beta Propeller SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 SUPERFAMILY SSF53474 476 733 8.47E-60 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 Gene3D G3DSA:3.40.50.1820 476 733 9.6E-60 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 Pfam PF00326 Prolyl oligopeptidase family 528 735 4.9E-42 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 PANTHER PTHR11731 339 736 3.7E-84 T 21-04-2016 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 PANTHER PTHR11731 1 286 3.7E-84 T 21-04-2016 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 SUPERFAMILY SSF82171 207 216 4.71E-26 T 21-04-2016 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 SUPERFAMILY SSF82171 244 468 4.71E-26 T 21-04-2016 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 SUPERFAMILY SSF82171 52 172 4.71E-26 T 21-04-2016 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 Gene3D G3DSA:2.130.10.10 339 467 1.3E-45 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 Gene3D G3DSA:2.130.10.10 250 286 1.3E-45 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS11655 ed89324bfcd90d794c2325ebe7bbc0d3 736 Gene3D G3DSA:2.130.10.10 43 180 1.3E-45 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS18130 4b0ac45370d4c7be06851fc7e0a34dea 189 Pfam PF13618 Gluconate 2-dehydrogenase subunit 3 43 172 2.0E-36 T 21-04-2016 IPR027056 Gluconate 2-dehydrogenase subunit 3 KEGG: 00030+1.1.99.3|MetaCyc: PWY-7165 SPH21_RS25160 e084d63f783c3044e1824d51b6954101 91 Gene3D G3DSA:3.40.10.10 29 84 4.5E-13 T 21-04-2016 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SPH21_RS25160 e084d63f783c3044e1824d51b6954101 91 SUPERFAMILY SSF57884 29 80 2.09E-11 T 21-04-2016 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SPH21_RS25160 e084d63f783c3044e1824d51b6954101 91 Pfam PF02805 Metal binding domain of Ada 36 74 2.4E-5 T 21-04-2016 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 55 70 2.55E-10 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 40 55 2.55E-10 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 8 23 2.55E-10 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 SMART SM00418 6 80 1.5E-13 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 Gene3D G3DSA:1.10.10.10 4 101 1.0E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 PANTHER PTHR33154 5 96 8.1E-22 T 21-04-2016 SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 Pfam PF12840 Helix-turn-helix domain 6 63 2.2E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 SUPERFAMILY SSF46785 2 96 5.79E-25 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13900 876b10cd7b0c18f841763e30d401fd0f 103 PANTHER PTHR33154:SF6 5 96 8.1E-22 T 21-04-2016 SPH21_RS19860 162787e27000d8a56edd2cb2c1a07a4d 312 PANTHER PTHR11203:SF35 1 201 2.4E-39 T 21-04-2016 SPH21_RS19860 162787e27000d8a56edd2cb2c1a07a4d 312 Gene3D G3DSA:3.60.15.10 26 145 7.7E-19 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS19860 162787e27000d8a56edd2cb2c1a07a4d 312 PANTHER PTHR11203 1 201 2.4E-39 T 21-04-2016 SPH21_RS19860 162787e27000d8a56edd2cb2c1a07a4d 312 SUPERFAMILY SSF56281 15 303 1.11E-41 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 6 319 4.5E-30 T 21-04-2016 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 109 287 7.3E-55 T 21-04-2016 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 PANTHER PTHR10996 1 324 1.9E-119 T 21-04-2016 SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 SUPERFAMILY SSF51735 102 288 1.75E-53 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 148 176 - T 21-04-2016 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 SUPERFAMILY SSF52283 2 135 1.64E-27 T 21-04-2016 SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 Gene3D G3DSA:3.40.50.720 110 288 6.6E-60 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19210 f0a6a18e2d64eb53fcbbd6c888d4bd58 326 Gene3D G3DSA:3.40.50.720 1 109 6.0E-30 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25335 5c9a94eeb9318c3ec6def1be91987e8d 262 Gene3D G3DSA:3.20.20.70 16 262 8.6E-94 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS25335 5c9a94eeb9318c3ec6def1be91987e8d 262 PANTHER PTHR21235 15 262 9.7E-117 T 21-04-2016 SPH21_RS25335 5c9a94eeb9318c3ec6def1be91987e8d 262 PANTHER PTHR21235:SF2 15 262 9.7E-117 T 21-04-2016 SPH21_RS25335 5c9a94eeb9318c3ec6def1be91987e8d 262 SUPERFAMILY SSF51366 15 262 1.57E-75 T 21-04-2016 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SPH21_RS25335 5c9a94eeb9318c3ec6def1be91987e8d 262 TIGRFAM TIGR00735 hisF: imidazoleglycerol phosphate synthase, cyclase subunit 14 262 2.2E-104 T 21-04-2016 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 UniPathway: UPA00031 SPH21_RS25335 5c9a94eeb9318c3ec6def1be91987e8d 262 Hamap MF_01013 Imidazole glycerol phosphate synthase subunit HisF [hisF]. 13 262 45.283 T 21-04-2016 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 UniPathway: UPA00031 SPH21_RS25335 5c9a94eeb9318c3ec6def1be91987e8d 262 Pfam PF00977 Histidine biosynthesis protein 17 245 1.7E-80 T 21-04-2016 IPR006062 Histidine biosynthesis GO:0000105 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 PANTHER PTHR24096:SF193 8 589 8.6E-176 T 21-04-2016 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 Gene3D G3DSA:2.30.38.10 393 449 1.4E-19 T 21-04-2016 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 ProSitePatterns PS00455 Putative AMP-binding domain signature. 175 186 - T 21-04-2016 IPR020845 AMP-binding, conserved site SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 Pfam PF00501 AMP-binding enzyme 19 455 4.6E-93 T 21-04-2016 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 PANTHER PTHR24096 8 589 8.6E-176 T 21-04-2016 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 Gene3D G3DSA:3.40.50.980 320 383 1.7E-28 T 21-04-2016 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 Gene3D G3DSA:3.40.50.980 182 271 1.7E-28 T 21-04-2016 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 Gene3D G3DSA:3.40.50.980 30 181 6.1E-31 T 21-04-2016 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 SUPERFAMILY SSF56801 323 587 7.98E-101 T 21-04-2016 SPH21_RS00120 862a6c872a0e78cca187a00abda15e72 597 SUPERFAMILY SSF56801 9 276 7.98E-101 T 21-04-2016 SPH21_RS20480 20485f8e786ca3a8e8eeeaf518a799bb 148 PANTHER PTHR33452:SF1 1 141 1.3E-16 T 21-04-2016 SPH21_RS20480 20485f8e786ca3a8e8eeeaf518a799bb 148 PANTHER PTHR33452 1 141 1.3E-16 T 21-04-2016 SPH21_RS20480 20485f8e786ca3a8e8eeeaf518a799bb 148 Pfam PF07681 DoxX 21 99 8.4E-10 T 21-04-2016 IPR032808 DoxX family SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 SUPERFAMILY SSF51064 145 200 2.09E-11 T 21-04-2016 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 Hamap MF_01151 Protein GrpE [grpE]. 7 201 18.113 T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 PRINTS PR00773 GrpE protein signature 98 113 9.1E-23 T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 PRINTS PR00773 GrpE protein signature 180 199 9.1E-23 T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 PRINTS PR00773 GrpE protein signature 152 167 9.1E-23 T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 PRINTS PR00773 GrpE protein signature 70 86 9.1E-23 T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 Gene3D G3DSA:3.90.20.20 45 142 8.4E-26 T 21-04-2016 IPR013805 GrpE nucleotide exchange factor, coiled-coil SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 Gene3D G3DSA:2.30.22.10 144 200 1.4E-16 T 21-04-2016 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 ProSitePatterns PS01071 grpE protein signature. 155 199 - T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 PANTHER PTHR21237 42 204 5.9E-40 T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 SUPERFAMILY SSF58014 53 144 1.12E-23 T 21-04-2016 SPH21_RS15530 85fccf2586497959a3ceb3e48b665853 204 Pfam PF01025 GrpE 43 200 2.1E-40 T 21-04-2016 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 SPH21_RS24690 6c42572889cce0d909336039450b27fe 255 SMART SM00342 168 250 4.6E-11 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24690 6c42572889cce0d909336039450b27fe 255 Pfam PF12833 Helix-turn-helix domain 175 251 3.5E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS24690 6c42572889cce0d909336039450b27fe 255 SUPERFAMILY SSF46689 217 250 2.37E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24690 6c42572889cce0d909336039450b27fe 255 Gene3D G3DSA:1.10.10.60 150 200 1.8E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24690 6c42572889cce0d909336039450b27fe 255 PANTHER PTHR11019 175 255 3.1E-13 T 21-04-2016 SPH21_RS24690 6c42572889cce0d909336039450b27fe 255 Gene3D G3DSA:1.10.10.60 209 249 4.6E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS03920 c59299b5f39e32d8e6348e6fad9d1f35 862 Pfam PF14903 WG containing repeat 665 694 7.8E-7 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03920 c59299b5f39e32d8e6348e6fad9d1f35 862 Pfam PF14903 WG containing repeat 761 791 0.15 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03920 c59299b5f39e32d8e6348e6fad9d1f35 862 Pfam PF14903 WG containing repeat 307 329 0.13 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03920 c59299b5f39e32d8e6348e6fad9d1f35 862 Pfam PF14903 WG containing repeat 349 379 4.8E-5 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS03920 c59299b5f39e32d8e6348e6fad9d1f35 862 Pfam PF14903 WG containing repeat 215 232 0.041 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS20275 a6cde967c0bc4b9f601f7e3b454fdf7a 200 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 9.3E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS20275 a6cde967c0bc4b9f601f7e3b454fdf7a 200 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 9.3E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS20275 a6cde967c0bc4b9f601f7e3b454fdf7a 200 SUPERFAMILY SSF46689 6 83 5.64E-18 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20275 a6cde967c0bc4b9f601f7e3b454fdf7a 200 PANTHER PTHR30055 3 156 3.1E-19 T 21-04-2016 SPH21_RS20275 a6cde967c0bc4b9f601f7e3b454fdf7a 200 Gene3D G3DSA:1.10.357.10 7 167 3.9E-31 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS20275 a6cde967c0bc4b9f601f7e3b454fdf7a 200 PANTHER PTHR30055:SF27 3 156 3.1E-19 T 21-04-2016 SPH21_RS20275 a6cde967c0bc4b9f601f7e3b454fdf7a 200 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 58 1.6E-13 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS14540 885ae801a57ee9cc24133797c99f2edf 191 PANTHER PTHR24421:SF16 9 183 1.1E-32 T 21-04-2016 SPH21_RS14540 885ae801a57ee9cc24133797c99f2edf 191 PANTHER PTHR24421 9 183 1.1E-32 T 21-04-2016 SPH21_RS14540 885ae801a57ee9cc24133797c99f2edf 191 SUPERFAMILY SSF52738 8 185 8.76E-48 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS14540 885ae801a57ee9cc24133797c99f2edf 191 Gene3D G3DSA:3.40.50.180 4 184 8.3E-57 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS14540 885ae801a57ee9cc24133797c99f2edf 191 Pfam PF01339 CheB methylesterase 12 184 1.8E-50 T 21-04-2016 IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase GO:0000156|GO:0000160|GO:0005737|GO:0006935|GO:0008984 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 SUPERFAMILY SSF81338 1 231 3.79E-63 T 21-04-2016 IPR023271 Aquaporin-like SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 Pfam PF00230 Major intrinsic protein 2 226 1.6E-47 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PRINTS PR00783 Major intrinsic protein family signature 2 21 9.8E-52 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PRINTS PR00783 Major intrinsic protein family signature 170 192 9.8E-52 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PRINTS PR00783 Major intrinsic protein family signature 140 158 9.8E-52 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PRINTS PR00783 Major intrinsic protein family signature 79 98 9.8E-52 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PRINTS PR00783 Major intrinsic protein family signature 42 66 9.8E-52 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PRINTS PR00783 Major intrinsic protein family signature 209 229 9.8E-52 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PANTHER PTHR19139 1 232 1.5E-69 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 TIGRFAM TIGR00861 MIP: MIP family channel proteins 6 226 1.6E-55 T 21-04-2016 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 PANTHER PTHR19139:SF103 1 232 1.5E-69 T 21-04-2016 SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 Gene3D G3DSA:1.20.1080.10 1 232 1.6E-66 T 21-04-2016 IPR023271 Aquaporin-like SPH21_RS25155 c4ebbb998e6b080f0c09032676920ba2 236 ProSitePatterns PS00221 MIP family signature. 60 68 - T 21-04-2016 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Pfam PF13361 UvrD-like helicase C-terminal domain 281 618 1.3E-72 T 21-04-2016 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Gene3D G3DSA:1.10.10.160 110 193 6.8E-20 T 21-04-2016 IPR013986 DExx box DNA helicase domain SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Gene3D G3DSA:3.40.50.300 194 288 9.0E-72 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Gene3D G3DSA:3.40.50.300 3 106 9.0E-72 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Gene3D G3DSA:3.40.50.300 554 642 4.5E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Gene3D G3DSA:3.40.50.300 289 391 4.5E-70 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 PANTHER PTHR11070:SF7 2 643 1.9E-201 T 21-04-2016 SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 SUPERFAMILY SSF52540 2 641 6.56E-173 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 PANTHER PTHR11070 2 643 1.9E-201 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Gene3D G3DSA:1.10.486.10 392 541 2.8E-37 T 21-04-2016 SPH21_RS14585 f4754573e4e5d063c586f24c6a7c1a15 761 Pfam PF00580 UvrD/REP helicase N-terminal domain 7 275 4.7E-74 T 21-04-2016 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SPH21_RS04735 559c67270f48718c0ba7315f925ec9bd 816 Pfam PF12704 MacB-like periplasmic core domain 20 240 6.6E-11 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS04735 559c67270f48718c0ba7315f925ec9bd 816 PANTHER PTHR30572:SF4 300 370 4.3E-69 T 21-04-2016 SPH21_RS04735 559c67270f48718c0ba7315f925ec9bd 816 PANTHER PTHR30572:SF4 425 816 4.3E-69 T 21-04-2016 SPH21_RS04735 559c67270f48718c0ba7315f925ec9bd 816 PANTHER PTHR30572 300 370 4.3E-69 T 21-04-2016 SPH21_RS04735 559c67270f48718c0ba7315f925ec9bd 816 PANTHER PTHR30572 425 816 4.3E-69 T 21-04-2016 SPH21_RS04735 559c67270f48718c0ba7315f925ec9bd 816 Pfam PF02687 FtsX-like permease family 303 416 1.3E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS04735 559c67270f48718c0ba7315f925ec9bd 816 Pfam PF02687 FtsX-like permease family 696 805 8.0E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS22390 c7cc4ef42aabd1f0a5e1a7a7a99ec65d 318 Pfam PF12849 PBP superfamily domain 27 291 1.2E-29 T 21-04-2016 IPR024370 PBP domain SPH21_RS22390 c7cc4ef42aabd1f0a5e1a7a7a99ec65d 318 PANTHER PTHR30570 31 317 1.5E-29 T 21-04-2016 SPH21_RS22390 c7cc4ef42aabd1f0a5e1a7a7a99ec65d 318 Gene3D G3DSA:3.40.190.10 33 172 1.7E-28 T 21-04-2016 SPH21_RS22390 c7cc4ef42aabd1f0a5e1a7a7a99ec65d 318 SUPERFAMILY SSF53850 32 318 2.78E-43 T 21-04-2016 SPH21_RS05880 802a064211686f46b8bd029b8ee6545d 70 SUPERFAMILY SSF47413 4 67 5.07E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS05880 802a064211686f46b8bd029b8ee6545d 70 Gene3D G3DSA:1.10.260.40 2 65 2.5E-19 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS05880 802a064211686f46b8bd029b8ee6545d 70 Pfam PF01381 Helix-turn-helix 9 61 9.1E-6 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS05775 da0b6fbe70ecd92bb0bb0fa8e6b7d2a5 224 PANTHER PTHR24220:SF342 3 219 2.4E-121 T 21-04-2016 SPH21_RS05775 da0b6fbe70ecd92bb0bb0fa8e6b7d2a5 224 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS05775 da0b6fbe70ecd92bb0bb0fa8e6b7d2a5 224 PANTHER PTHR24220 3 219 2.4E-121 T 21-04-2016 SPH21_RS05775 da0b6fbe70ecd92bb0bb0fa8e6b7d2a5 224 SUPERFAMILY SSF52540 1 220 1.15E-73 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05775 da0b6fbe70ecd92bb0bb0fa8e6b7d2a5 224 Pfam PF00005 ABC transporter 21 169 2.1E-35 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS05775 da0b6fbe70ecd92bb0bb0fa8e6b7d2a5 224 Gene3D G3DSA:3.40.50.300 1 220 3.0E-71 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS05775 da0b6fbe70ecd92bb0bb0fa8e6b7d2a5 224 SMART SM00382 30 217 5.0E-15 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS21560 23bc183ea026cb0d6209cac8907a5fc7 123 Pfam PF02687 FtsX-like permease family 3 114 1.3E-15 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS21560 23bc183ea026cb0d6209cac8907a5fc7 123 PANTHER PTHR30572 2 123 3.6E-39 T 21-04-2016 SPH21_RS21560 23bc183ea026cb0d6209cac8907a5fc7 123 PANTHER PTHR30572:SF4 2 123 3.6E-39 T 21-04-2016 SPH21_RS25535 83af1903e76fef74bcf5d8d75c6e38fe 530 PIRSF PIRSF012535 5 528 4.4E-90 T 21-04-2016 IPR011199 Bacillithiol biosynthesis BshC SPH21_RS25535 83af1903e76fef74bcf5d8d75c6e38fe 530 Hamap MF_01867 Putative cysteine ligase BshC [bshC]. 4 530 24.097 T 21-04-2016 IPR011199 Bacillithiol biosynthesis BshC SPH21_RS25535 83af1903e76fef74bcf5d8d75c6e38fe 530 TIGRFAM TIGR03998 thiol_BshC: bacillithiol biosynthesis cysteine-adding enzyme BshC 15 528 1.6E-133 T 21-04-2016 IPR011199 Bacillithiol biosynthesis BshC SPH21_RS25535 83af1903e76fef74bcf5d8d75c6e38fe 530 PANTHER PTHR41301 41 513 2.6E-51 T 21-04-2016 SPH21_RS25535 83af1903e76fef74bcf5d8d75c6e38fe 530 Pfam PF10079 Uncharacterized protein conserved in bacteria (DUF2317) 1 528 3.7E-189 T 21-04-2016 IPR011199 Bacillithiol biosynthesis BshC SPH21_RS24795 13eda720a13f31e166e6a134c1c567a1 216 PANTHER PTHR30055 19 214 2.2E-36 T 21-04-2016 SPH21_RS24795 13eda720a13f31e166e6a134c1c567a1 216 Gene3D G3DSA:1.10.357.10 82 212 1.5E-12 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS24795 13eda720a13f31e166e6a134c1c567a1 216 SUPERFAMILY SSF48498 103 214 9.58E-16 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS24795 13eda720a13f31e166e6a134c1c567a1 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 37 80 1.9E-7 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS24795 13eda720a13f31e166e6a134c1c567a1 216 SUPERFAMILY SSF46689 27 107 1.18E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24795 13eda720a13f31e166e6a134c1c567a1 216 PANTHER PTHR30055:SF44 19 214 2.2E-36 T 21-04-2016 SPH21_RS24795 13eda720a13f31e166e6a134c1c567a1 216 Gene3D G3DSA:1.10.10.60 29 81 2.4E-18 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 Pfam PF07687 Peptidase dimerisation domain 206 281 3.4E-7 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 PANTHER PTHR30575 125 351 2.8E-72 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 PANTHER PTHR30575 377 467 2.8E-72 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 PANTHER PTHR30575 15 107 2.8E-72 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 SUPERFAMILY SSF55031 206 318 5.41E-17 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 TIGRFAM TIGR01891 amidohydrolases: amidohydrolase 43 408 1.6E-45 T 21-04-2016 IPR017439 Amidohydrolase GO:0016787 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 Gene3D G3DSA:3.40.630.10 383 459 1.2E-43 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 Gene3D G3DSA:3.40.630.10 19 205 1.2E-43 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 Gene3D G3DSA:3.40.630.10 317 349 1.2E-43 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 Gene3D G3DSA:3.30.70.360 206 313 6.8E-20 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 SUPERFAMILY SSF53187 320 349 5.94E-41 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 SUPERFAMILY SSF53187 29 221 5.94E-41 T 21-04-2016 SPH21_RS24705 651208eab9a5c1c91ba413fefc10bfff 518 SUPERFAMILY SSF53187 383 447 5.94E-41 T 21-04-2016 SPH21_RS06945 006349ad9c8be0ae680ea0fc78e2697a 186 TIGRFAM TIGR04409 LptC_YrbK: LPS export ABC transporter periplasmic protein LptC 15 176 1.2E-15 T 21-04-2016 IPR026265 Lipopolysaccharide export system protein LptC GO:0005887|GO:0015221|GO:0015920 SPH21_RS06945 006349ad9c8be0ae680ea0fc78e2697a 186 Pfam PF06835 Lipopolysaccharide-assembly, LptC-related 31 171 5.7E-13 T 21-04-2016 IPR010664 Lipopolysaccharide assembly, LptC-related SPH21_RS04065 f03d595df6f17502623a3d73e7dbe7c3 430 Pfam PF13635 Domain of unknown function (DUF4143) 220 383 3.4E-28 T 21-04-2016 IPR025420 Domain of unknown function DUF4143 SPH21_RS04065 f03d595df6f17502623a3d73e7dbe7c3 430 Pfam PF13173 AAA domain 17 152 9.8E-28 T 21-04-2016 SPH21_RS04065 f03d595df6f17502623a3d73e7dbe7c3 430 PANTHER PTHR33295 1 426 1.5E-180 T 21-04-2016 SPH21_RS04065 f03d595df6f17502623a3d73e7dbe7c3 430 PANTHER PTHR33295:SF7 1 426 1.5E-180 T 21-04-2016 SPH21_RS04065 f03d595df6f17502623a3d73e7dbe7c3 430 SUPERFAMILY SSF52540 10 215 1.49E-18 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS04065 f03d595df6f17502623a3d73e7dbe7c3 430 Gene3D G3DSA:3.40.50.300 13 124 1.6E-7 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS15410 485123e50264c30623c41c610e07ef3d 234 PANTHER PTHR31223 7 228 3.3E-100 T 21-04-2016 SPH21_RS15410 485123e50264c30623c41c610e07ef3d 234 Pfam PF03641 Possible lysine decarboxylase 89 220 1.3E-35 T 21-04-2016 IPR031100 LOG family SPH21_RS15410 485123e50264c30623c41c610e07ef3d 234 TIGRFAM TIGR00730 TIGR00730: TIGR00730 family protein 47 221 8.2E-44 T 21-04-2016 IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG SPH21_RS15410 485123e50264c30623c41c610e07ef3d 234 PANTHER PTHR31223:SF1 7 228 3.3E-100 T 21-04-2016 SPH21_RS15410 485123e50264c30623c41c610e07ef3d 234 SUPERFAMILY SSF102405 16 221 9.01E-63 T 21-04-2016 SPH21_RS15410 485123e50264c30623c41c610e07ef3d 234 Gene3D G3DSA:3.40.50.450 24 227 1.5E-66 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 SUPERFAMILY SSF49464 53 135 2.62E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Gene3D G3DSA:2.40.170.20 369 443 3.8E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Gene3D G3DSA:2.40.170.20 927 952 3.8E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Gene3D G3DSA:2.40.170.20 255 276 3.8E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Gene3D G3DSA:2.40.170.20 484 853 3.8E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Gene3D G3DSA:2.40.170.20 996 1099 3.8E-54 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Gene3D G3DSA:2.170.130.10 146 254 4.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 227 257 8.7E-18 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Pfam PF13715 CarboxypepD_reg-like domain 55 137 1.1E-15 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Pfam PF07715 TonB-dependent Receptor Plug Domain 146 251 2.4E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 53 1099 1.3E-261 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532 499 546 9.2E-251 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532 626 1097 9.2E-251 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532 568 594 9.2E-251 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532 48 414 9.2E-251 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 SUPERFAMILY SSF56935 918 962 1.37E-88 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 SUPERFAMILY SSF56935 489 842 1.37E-88 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 SUPERFAMILY SSF56935 360 448 1.37E-88 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 SUPERFAMILY SSF56935 1003 1099 1.37E-88 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 SUPERFAMILY SSF56935 131 275 1.37E-88 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 Gene3D G3DSA:2.60.40.1120 54 140 7.5E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532:SF57 499 546 9.2E-251 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532:SF57 626 1097 9.2E-251 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532:SF57 568 594 9.2E-251 T 21-04-2016 SPH21_RS06200 193efcf5f79baf6346ee4ac2a663e381 1099 PANTHER PTHR11532:SF57 48 414 9.2E-251 T 21-04-2016 SPH21_RS06645 5155b25b31d2e316ad99093994585c37 119 PANTHER PTHR33169:SF1 1 102 1.5E-29 T 21-04-2016 SPH21_RS06645 5155b25b31d2e316ad99093994585c37 119 SUPERFAMILY SSF46785 8 101 2.06E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06645 5155b25b31d2e316ad99093994585c37 119 Pfam PF03551 Transcriptional regulator PadR-like family 19 89 2.6E-18 T 21-04-2016 IPR005149 Transcription regulator PadR, N-terminal SPH21_RS06645 5155b25b31d2e316ad99093994585c37 119 Gene3D G3DSA:1.10.10.10 5 103 6.1E-27 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06645 5155b25b31d2e316ad99093994585c37 119 PANTHER PTHR33169 1 102 1.5E-29 T 21-04-2016 SPH21_RS10150 1c59fe338b501c53a319494439e2e838 241 Pfam PF04450 Peptidase of plants and bacteria 59 234 4.2E-27 T 21-04-2016 IPR007541 Uncharacterised protein family, basic secretory protein SPH21_RS10150 1c59fe338b501c53a319494439e2e838 241 PANTHER PTHR33321:SF2 126 237 9.9E-23 T 21-04-2016 SPH21_RS10150 1c59fe338b501c53a319494439e2e838 241 PANTHER PTHR33321 126 237 9.9E-23 T 21-04-2016 SPH21_RS02130 23cb71abb3db3c019a5ae1d0f60d4693 431 Pfam PF07690 Major Facilitator Superfamily 25 299 2.8E-20 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS02130 23cb71abb3db3c019a5ae1d0f60d4693 431 PANTHER PTHR11360 194 426 1.7E-12 T 21-04-2016 SPH21_RS02130 23cb71abb3db3c019a5ae1d0f60d4693 431 PANTHER PTHR11360 45 52 1.7E-12 T 21-04-2016 SPH21_RS02130 23cb71abb3db3c019a5ae1d0f60d4693 431 Gene3D G3DSA:1.20.1250.20 226 413 1.2E-24 T 21-04-2016 SPH21_RS02130 23cb71abb3db3c019a5ae1d0f60d4693 431 Gene3D G3DSA:1.20.1250.20 16 206 1.8E-21 T 21-04-2016 SPH21_RS02130 23cb71abb3db3c019a5ae1d0f60d4693 431 SUPERFAMILY SSF103473 16 412 1.07E-52 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 Pfam PF01336 OB-fold nucleic acid binding domain 56 138 2.4E-16 T 21-04-2016 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 SUPERFAMILY SSF50249 6 146 5.57E-34 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 PANTHER PTHR22594 5 512 1.8E-243 T 21-04-2016 IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 SUPERFAMILY SSF55681 161 499 9.96E-112 T 21-04-2016 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 TIGRFAM TIGR00499 lysS_bact: lysine--tRNA ligase 7 502 9.7E-183 T 21-04-2016 IPR002313 Lysine-tRNA ligase, class II GO:0004824|GO:0005524|GO:0006430 KEGG: 00970+6.1.1.6 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 Gene3D G3DSA:2.40.50.140 6 146 3.9E-40 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 PANTHER PTHR22594:SF4 5 512 1.8E-243 T 21-04-2016 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 PRINTS PR00982 Lysyl-tRNA synthetase signature 198 208 1.3E-36 T 21-04-2016 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 PRINTS PR00982 Lysyl-tRNA synthetase signature 214 230 1.3E-36 T 21-04-2016 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 PRINTS PR00982 Lysyl-tRNA synthetase signature 243 256 1.3E-36 T 21-04-2016 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 PRINTS PR00982 Lysyl-tRNA synthetase signature 261 278 1.3E-36 T 21-04-2016 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 PRINTS PR00982 Lysyl-tRNA synthetase signature 383 399 1.3E-36 T 21-04-2016 IPR018149 Lysyl-tRNA synthetase, class II, C-terminal GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 Gene3D G3DSA:3.30.930.10 160 498 4.3E-111 T 21-04-2016 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 Pfam PF00152 tRNA synthetases class II (D, K and N) 162 498 8.4E-77 T 21-04-2016 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N) GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS11925 8b3fc37b9e914a89b72b8ad042649597 572 Hamap MF_00252 Lysine--tRNA ligase [lysS]. 11 501 41.834 T 21-04-2016 IPR002313 Lysine-tRNA ligase, class II GO:0004824|GO:0005524|GO:0006430 KEGG: 00970+6.1.1.6 SPH21_RS08325 b17e5cf983d90d566556cd68b02e7a03 288 PANTHER PTHR10366 251 287 6.1E-36 T 21-04-2016 SPH21_RS08325 b17e5cf983d90d566556cd68b02e7a03 288 PANTHER PTHR10366 2 230 6.1E-36 T 21-04-2016 SPH21_RS08325 b17e5cf983d90d566556cd68b02e7a03 288 SUPERFAMILY SSF51735 1 284 5.94E-29 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08325 b17e5cf983d90d566556cd68b02e7a03 288 PANTHER PTHR10366:SF401 251 287 6.1E-36 T 21-04-2016 SPH21_RS08325 b17e5cf983d90d566556cd68b02e7a03 288 PANTHER PTHR10366:SF401 2 230 6.1E-36 T 21-04-2016 SPH21_RS08325 b17e5cf983d90d566556cd68b02e7a03 288 Gene3D G3DSA:3.40.50.720 1 217 2.2E-21 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21520 c2d7178ace3e94a2758e9138201fdd63 136 Gene3D G3DSA:3.10.450.50 12 135 2.4E-65 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS21520 c2d7178ace3e94a2758e9138201fdd63 136 PANTHER PTHR31757 1 136 4.6E-75 T 21-04-2016 SPH21_RS21520 c2d7178ace3e94a2758e9138201fdd63 136 PANTHER PTHR31757:SF0 1 136 4.6E-75 T 21-04-2016 SPH21_RS21520 c2d7178ace3e94a2758e9138201fdd63 136 SUPERFAMILY SSF54427 1 135 6.04E-70 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS21520 c2d7178ace3e94a2758e9138201fdd63 136 Pfam PF07080 Protein of unknown function (DUF1348) 5 135 3.9E-67 T 21-04-2016 IPR009783 Protein of unknown function DUF1348 SPH21_RS03490 441eaed07b9c80b45342f47f7a130ccc 244 PANTHER PTHR38480 1 238 7.5E-34 T 21-04-2016 SPH21_RS03490 441eaed07b9c80b45342f47f7a130ccc 244 Pfam PF06271 RDD family 18 145 2.4E-21 T 21-04-2016 IPR010432 RDD SPH21_RS03490 441eaed07b9c80b45342f47f7a130ccc 244 PANTHER PTHR38480:SF1 1 238 7.5E-34 T 21-04-2016 SPH21_RS20490 ae65729d9d17722780878cc598f37fa7 278 SUPERFAMILY SSF51161 78 255 1.66E-42 T 21-04-2016 IPR011004 Trimeric LpxA-like SPH21_RS20490 ae65729d9d17722780878cc598f37fa7 278 PANTHER PTHR23416 23 255 2.6E-84 T 21-04-2016 SPH21_RS20490 ae65729d9d17722780878cc598f37fa7 278 Gene3D G3DSA:1.10.3130.10 19 152 3.9E-31 T 21-04-2016 SPH21_RS20490 ae65729d9d17722780878cc598f37fa7 278 Gene3D G3DSA:2.160.10.10 153 256 3.7E-27 T 21-04-2016 SPH21_RS20490 ae65729d9d17722780878cc598f37fa7 278 PANTHER PTHR23416:SF65 23 255 2.6E-84 T 21-04-2016 SPH21_RS11415 8d6ac46cf26362168d7867aee6ee1da5 228 Pfam PF12875 Protein of unknown function (DUF3826) 38 219 2.9E-73 T 21-04-2016 IPR024284 Protein of unknown function DUF3826 SPH21_RS06895 90132b1b6a85a1cff4651df9cccdd420 123 Gene3D G3DSA:1.10.10.10 1 77 9.3E-25 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06895 90132b1b6a85a1cff4651df9cccdd420 123 SUPERFAMILY SSF46785 4 122 1.77E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS06895 90132b1b6a85a1cff4651df9cccdd420 123 PIRSF PIRSF019455 1 123 3.9E-27 T 21-04-2016 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SPH21_RS06895 90132b1b6a85a1cff4651df9cccdd420 123 PANTHER PTHR34134 2 123 4.5E-33 T 21-04-2016 SPH21_RS06895 90132b1b6a85a1cff4651df9cccdd420 123 Pfam PF03965 Penicillinase repressor 6 118 4.6E-30 T 21-04-2016 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SPH21_RS19105 bf9856f12c60e354014bb8a8db6fab37 213 SUPERFAMILY SSF56784 4 211 1.16E-45 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS19105 bf9856f12c60e354014bb8a8db6fab37 213 PANTHER PTHR18901 4 211 1.3E-47 T 21-04-2016 SPH21_RS19105 bf9856f12c60e354014bb8a8db6fab37 213 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 75 182 1.3E-12 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS19105 bf9856f12c60e354014bb8a8db6fab37 213 Pfam PF13419 Haloacid dehalogenase-like hydrolase 7 182 8.8E-22 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS19105 bf9856f12c60e354014bb8a8db6fab37 213 Gene3D G3DSA:3.40.50.1000 86 211 4.6E-37 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS19105 bf9856f12c60e354014bb8a8db6fab37 213 Gene3D G3DSA:3.40.50.1000 3 19 4.6E-37 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS18145 3323d4f5e9ae2127b6cd60c197834522 412 Pfam PF03825 Nucleoside H+ symporter 5 405 3.6E-114 T 21-04-2016 SPH21_RS18145 3323d4f5e9ae2127b6cd60c197834522 412 Gene3D G3DSA:1.20.1250.20 209 405 5.8E-22 T 21-04-2016 SPH21_RS18145 3323d4f5e9ae2127b6cd60c197834522 412 Gene3D G3DSA:1.20.1250.20 9 196 6.6E-15 T 21-04-2016 SPH21_RS18145 3323d4f5e9ae2127b6cd60c197834522 412 SUPERFAMILY SSF103473 9 407 9.94E-39 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS18145 3323d4f5e9ae2127b6cd60c197834522 412 PANTHER PTHR23522 1 412 2.6E-129 T 21-04-2016 SPH21_RS18145 3323d4f5e9ae2127b6cd60c197834522 412 PANTHER PTHR23522:SF1 1 412 2.6E-129 T 21-04-2016 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 Gene3D G3DSA:1.10.3080.10 29 457 2.6E-72 T 21-04-2016 IPR014743 Chloride channel, core GO:0005216|GO:0055085 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 SUPERFAMILY SSF54631 468 588 4.45E-17 T 21-04-2016 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 Gene3D G3DSA:3.10.580.10 466 587 2.5E-16 T 21-04-2016 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 Pfam PF00571 CBS domain 534 584 0.0011 T 21-04-2016 IPR000644 CBS domain SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 PANTHER PTHR11689:SF14 40 524 2.7E-60 T 21-04-2016 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 Pfam PF00654 Voltage gated chloride channel 93 435 1.8E-75 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 PRINTS PR00762 Chloride channel signature 404 423 9.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 PRINTS PR00762 Chloride channel signature 187 206 9.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 PRINTS PR00762 Chloride channel signature 386 402 9.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 PRINTS PR00762 Chloride channel signature 351 371 9.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 PRINTS PR00762 Chloride channel signature 136 155 9.3E-19 T 21-04-2016 IPR001807 Chloride channel, voltage gated GO:0005247|GO:0006821|GO:0016020|GO:0055085 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 PANTHER PTHR11689 40 524 2.7E-60 T 21-04-2016 SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 SMART SM00116 539 587 0.0072 T 21-04-2016 IPR000644 CBS domain SPH21_RS16100 2172e18ae8b4989924f1decb01cafb80 620 SUPERFAMILY SSF81340 26 453 6.8E-94 T 21-04-2016 IPR014743 Chloride channel, core GO:0005216|GO:0055085 SPH21_RS12160 079c8770326d2d3356bafc705a1da790 143 Pfam PF03724 META domain 32 129 2.8E-15 T 21-04-2016 IPR005184 Domain of unknown function DUF306, Meta/HslJ SPH21_RS14835 09f343c400aff0919338f761a04c1ce9 219 Pfam PF03379 CcmB protein 9 209 1.3E-10 T 21-04-2016 IPR003544 Cytochrome c-type biogenesis protein CcmB GO:0015232|GO:0015886|GO:0016020|GO:0017004 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 SUPERFAMILY SSF46689 217 263 1.75E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 SMART SM00342 177 260 1.3E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 Gene3D G3DSA:1.10.10.60 217 262 3.2E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 229 244 2.9E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 244 260 2.9E-6 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 PANTHER PTHR11019:SF45 9 268 3.2E-32 T 21-04-2016 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 PANTHER PTHR11019 9 268 3.2E-32 T 21-04-2016 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 Pfam PF12833 Helix-turn-helix domain 183 261 3.9E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS23435 9ee41818d076e9ac218b42179960bc2e 270 Gene3D G3DSA:1.10.10.60 168 213 7.0E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS25300 3c976ce5d9036bcebda928c72a536b1a 421 Pfam PF00668 Condensation domain 19 249 4.4E-11 T 21-04-2016 IPR001242 Condensation domain SPH21_RS25300 3c976ce5d9036bcebda928c72a536b1a 421 SUPERFAMILY SSF52777 6 147 9.45E-18 T 21-04-2016 SPH21_RS25300 3c976ce5d9036bcebda928c72a536b1a 421 SUPERFAMILY SSF52777 190 409 1.01E-11 T 21-04-2016 SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 PANTHER PTHR11647 25 120 2.6E-19 T 21-04-2016 SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 PANTHER PTHR11647:SF73 25 120 2.6E-19 T 21-04-2016 SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 PIRSF PIRSF039004 19 417 2.9E-112 T 21-04-2016 IPR020043 Amidohydrolase EF0837/AHA3915, putative KEGG: 00051+3.1.1.-|KEGG: 00053+3.1.1.-|KEGG: 00363+3.1.1.-|KEGG: 00365+3.1.1.-|KEGG: 00534+3.1.1.-|KEGG: 00564+3.1.1.-|KEGG: 00623+3.1.1.-|KEGG: 00640+3.1.1.-|KEGG: 00830+3.1.1.-|KEGG: 00900+3.1.1.-|KEGG: 00940+3.1.1.-|KEGG: 00960+3.1.1.- SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 SUPERFAMILY SSF51338 24 98 2.0E-18 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 Gene3D G3DSA:2.30.40.10 339 401 1.6E-6 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 Gene3D G3DSA:2.30.40.10 24 92 1.1E-16 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 Pfam PF01979 Amidohydrolase family 288 367 1.2E-9 T 21-04-2016 IPR006680 Amidohydrolase-related GO:0016787 SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 SUPERFAMILY SSF51556 77 352 3.96E-42 T 21-04-2016 IPR032466 Metal-dependent hydrolase SPH21_RS14725 c55599e5512ae9f0df6ccb0b145bf2b1 419 Gene3D G3DSA:3.20.20.140 93 338 4.5E-86 T 21-04-2016 SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 Gene3D G3DSA:3.40.50.1820 3 252 4.1E-45 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 SUPERFAMILY SSF53474 1 253 1.32E-42 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 Pfam PF00561 alpha/beta hydrolase fold 23 145 4.9E-16 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 PANTHER PTHR10992 4 253 1.7E-40 T 21-04-2016 SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 PRINTS PR00111 Alpha/beta hydrolase fold signature 200 214 6.2E-9 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 PRINTS PR00111 Alpha/beta hydrolase fold signature 48 63 6.2E-9 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 PRINTS PR00111 Alpha/beta hydrolase fold signature 92 105 6.2E-9 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS18490 b6bec1577de0cdc0f5faaebf6ba72276 258 PRINTS PR00111 Alpha/beta hydrolase fold signature 106 119 6.2E-9 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS00585 bd2c777073b914313e45de1fd826959a 177 SUPERFAMILY SSF160574 63 156 6.93E-9 T 21-04-2016 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 PANTHER PTHR11922:SF5 74 328 2.2E-77 T 21-04-2016 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 PANTHER PTHR11922 74 328 2.2E-77 T 21-04-2016 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 SUPERFAMILY SSF52418 71 328 2.62E-73 T 21-04-2016 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 Hamap MF_00211 Anthranilate phosphoribosyltransferase [trpD]. 3 329 29.489 T 21-04-2016 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18|UniPathway: UPA00035 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 Pfam PF02885 Glycosyl transferase family, helical bundle domain 3 62 2.1E-15 T 21-04-2016 IPR017459 Glycosyl transferase family 3, N-terminal domain SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 Gene3D G3DSA:1.20.970.10 1 63 1.6E-16 T 21-04-2016 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 TIGRFAM TIGR01245 trpD: anthranilate phosphoribosyltransferase 6 327 1.4E-89 T 21-04-2016 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18|UniPathway: UPA00035 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 SUPERFAMILY SSF47648 1 68 4.32E-16 T 21-04-2016 IPR017459 Glycosyl transferase family 3, N-terminal domain SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 Gene3D G3DSA:3.40.1030.10 72 329 1.9E-80 T 21-04-2016 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 SPH21_RS15425 f950563f6a66b4dff84de86578a95a0a 334 Pfam PF00591 Glycosyl transferase family, a/b domain 72 319 3.5E-63 T 21-04-2016 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 SMART SM01232 122 211 1.3E-22 T 21-04-2016 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 Gene3D G3DSA:3.20.190.10 2 122 4.0E-19 T 21-04-2016 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 PANTHER PTHR22993:SF15 1 250 4.5E-38 T 21-04-2016 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 SMART SM00898 2 115 2.0E-10 T 21-04-2016 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 113 1.2E-19 T 21-04-2016 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 124 202 2.3E-21 T 21-04-2016 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 SUPERFAMILY SSF81624 2 130 1.11E-17 T 21-04-2016 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 SUPERFAMILY SSF46946 124 203 1.7E-21 T 21-04-2016 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 PANTHER PTHR22993 1 250 4.5E-38 T 21-04-2016 SPH21_RS16105 209c07260112d0705598a958997b6bd6 258 Gene3D G3DSA:1.10.8.50 124 251 4.3E-28 T 21-04-2016 SPH21_RS04480 33f4f9fb005602fd817eb23f8e5b49f7 379 PANTHER PTHR23028:SF54 1 375 2.3E-154 T 21-04-2016 SPH21_RS04480 33f4f9fb005602fd817eb23f8e5b49f7 379 Pfam PF01757 Acyltransferase family 19 360 2.1E-32 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS04480 33f4f9fb005602fd817eb23f8e5b49f7 379 PANTHER PTHR23028 1 375 2.3E-154 T 21-04-2016 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 PIRSF PIRSF034961 3 118 1.3E-29 T 21-04-2016 IPR014593 Uncharacterised conserved protein UCP034961, SH3-2 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 Gene3D G3DSA:2.30.30.40 3 60 1.2E-8 T 21-04-2016 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 SMART SM00326 3 62 0.037 T 21-04-2016 IPR001452 SH3 domain GO:0005515 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 SMART SM00326 65 118 1.3 T 21-04-2016 IPR001452 SH3 domain GO:0005515 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 SUPERFAMILY SSF50044 3 63 3.54E-10 T 21-04-2016 IPR001452 SH3 domain GO:0005515 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 SUPERFAMILY SSF50044 74 113 9.32E-6 T 21-04-2016 IPR001452 SH3 domain GO:0005515 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 Pfam PF00018 SH3 domain 74 110 8.0E-6 T 21-04-2016 IPR001452 SH3 domain GO:0005515 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 Gene3D G3DSA:2.30.30.40 75 111 3.7E-6 T 21-04-2016 SPH21_RS01055 b2076494fb075f50d5357f37d173ca0e 118 Pfam PF07653 Variant SH3 domain 5 59 5.2E-9 T 21-04-2016 IPR011511 Variant SH3 domain SPH21_RS21815 80b6f276ab7c7945986420be0c52dfc4 394 Pfam PF13635 Domain of unknown function (DUF4143) 195 352 5.2E-17 T 21-04-2016 IPR025420 Domain of unknown function DUF4143 SPH21_RS21815 80b6f276ab7c7945986420be0c52dfc4 394 SUPERFAMILY SSF52540 6 181 5.62E-21 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21815 80b6f276ab7c7945986420be0c52dfc4 394 Gene3D G3DSA:3.40.50.300 7 140 2.3E-16 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21815 80b6f276ab7c7945986420be0c52dfc4 394 Pfam PF13173 AAA domain 21 150 1.8E-23 T 21-04-2016 SPH21_RS21815 80b6f276ab7c7945986420be0c52dfc4 394 PANTHER PTHR33295 1 350 3.9E-40 T 21-04-2016 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 Gene3D G3DSA:1.10.10.60 159 208 4.5E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 PANTHER PTHR24423 14 166 2.1E-58 T 21-04-2016 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 PANTHER PTHR24423:SF486 14 166 2.1E-58 T 21-04-2016 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 SUPERFAMILY SSF52172 11 141 3.98E-36 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 Gene3D G3DSA:3.40.50.2300 8 136 2.0E-39 T 21-04-2016 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 241 257 4.9E-7 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 226 241 4.9E-7 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 SMART SM00448 12 124 4.9E-34 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 SMART SM00342 174 257 3.7E-27 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 SUPERFAMILY SSF46689 211 260 1.25E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 Gene3D G3DSA:1.10.10.60 211 256 1.5E-17 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 Pfam PF12833 Helix-turn-helix domain 180 257 1.2E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS02905 e6a3211726708b3c66eaa462b2f0aeed 264 Pfam PF00072 Response regulator receiver domain 15 123 2.4E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS06425 361d414afff23ac4ea67214f591fcdcc 266 PANTHER PTHR13773 1 266 5.9E-57 T 21-04-2016 SPH21_RS06425 361d414afff23ac4ea67214f591fcdcc 266 Pfam PF01148 Cytidylyltransferase family 2 264 3.9E-58 T 21-04-2016 SPH21_RS06425 361d414afff23ac4ea67214f591fcdcc 266 PANTHER PTHR13773:SF0 1 266 5.9E-57 T 21-04-2016 SPH21_RS06425 361d414afff23ac4ea67214f591fcdcc 266 ProSitePatterns PS01315 Phosphatidate cytidylyltransferase signature. 223 249 - T 21-04-2016 IPR000374 Phosphatidate cytidylyltransferase GO:0016020|GO:0016772 KEGG: 00564+2.7.7.41|KEGG: 04070+2.7.7.41|MetaCyc: PWY-5667|MetaCyc: PWY-5981|UniPathway: UPA00557 SPH21_RS10135 9a2c25fb3c34bedde30b95da58c64cc0 548 Pfam PF14322 Starch-binding associating with outer membrane 52 230 1.9E-10 T 21-04-2016 SPH21_RS10135 9a2c25fb3c34bedde30b95da58c64cc0 548 Pfam PF07980 SusD family 281 547 1.3E-23 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS10135 9a2c25fb3c34bedde30b95da58c64cc0 548 Gene3D G3DSA:1.25.40.10 402 494 4.8E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10135 9a2c25fb3c34bedde30b95da58c64cc0 548 Gene3D G3DSA:1.25.40.10 213 331 4.8E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10135 9a2c25fb3c34bedde30b95da58c64cc0 548 SUPERFAMILY SSF48452 22 547 2.4E-99 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS17845 3372ea43fd4e6550b6aa101584402c65 666 Pfam PF14293 YWFCY protein 2 61 5.2E-28 T 21-04-2016 IPR025988 YWFCY domain SPH21_RS17845 3372ea43fd4e6550b6aa101584402c65 666 SUPERFAMILY SSF52540 189 575 9.74E-32 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17845 3372ea43fd4e6550b6aa101584402c65 666 Pfam PF12696 TraM recognition site of TraD and TraG 459 570 1.1E-14 T 21-04-2016 IPR032689 TraD/TraG, TraM recognition site SPH21_RS17845 3372ea43fd4e6550b6aa101584402c65 666 Gene3D G3DSA:3.40.50.300 411 576 6.4E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17845 3372ea43fd4e6550b6aa101584402c65 666 Gene3D G3DSA:3.40.50.300 201 275 6.4E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS25175 08ece0510093fc839069822e95eaa7cc 130 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 11 123 2.1E-6 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS25175 08ece0510093fc839069822e95eaa7cc 130 SUPERFAMILY SSF54593 12 128 2.69E-17 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS25175 08ece0510093fc839069822e95eaa7cc 130 Gene3D G3DSA:3.10.180.10 13 128 1.5E-16 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PANTHER PTHR22594:SF5 1 298 3.0E-246 T 21-04-2016 IPR004524 Aspartate-tRNA ligase, bacterial/mitochondrial-type GO:0005524|GO:0016874 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PANTHER PTHR22594:SF5 365 567 3.0E-246 T 21-04-2016 IPR004524 Aspartate-tRNA ligase, bacterial/mitochondrial-type GO:0005524|GO:0016874 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PRINTS PR01042 Aspartyl-tRNA synthetase signature 192 204 8.3E-25 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PRINTS PR01042 Aspartyl-tRNA synthetase signature 209 222 8.3E-25 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PRINTS PR01042 Aspartyl-tRNA synthetase signature 470 486 8.3E-25 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PRINTS PR01042 Aspartyl-tRNA synthetase signature 514 528 8.3E-25 T 21-04-2016 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PANTHER PTHR22594 1 298 3.0E-246 T 21-04-2016 IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 PANTHER PTHR22594 365 567 3.0E-246 T 21-04-2016 IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Hamap MF_00044 Aspartate--tRNA(Asp) ligase [aspS]. 2 559 34.189 T 21-04-2016 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Pfam PF00152 tRNA synthetases class II (D, K and N) 121 553 7.0E-108 T 21-04-2016 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N) GO:0000166|GO:0004812|GO:0005524|GO:0006418 Reactome: REACT_71 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 TIGRFAM TIGR00459 aspS_bact: aspartate--tRNA ligase 2 579 2.1E-224 T 21-04-2016 IPR004524 Aspartate-tRNA ligase, bacterial/mitochondrial-type GO:0005524|GO:0016874 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Pfam PF01336 OB-fold nucleic acid binding domain 20 101 9.0E-12 T 21-04-2016 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 SUPERFAMILY SSF55261 290 414 1.13E-31 T 21-04-2016 IPR004115 GAD-like domain GO:0004812|GO:0005524|GO:0005737 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Gene3D G3DSA:3.30.1360.30 278 409 1.9E-41 T 21-04-2016 IPR004115 GAD-like domain GO:0004812|GO:0005524|GO:0005737 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Pfam PF02938 GAD domain 313 400 5.2E-13 T 21-04-2016 IPR029351 GAD domain SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Gene3D G3DSA:2.40.50.140 1 106 8.7E-35 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 SUPERFAMILY SSF55681 420 579 2.59E-102 T 21-04-2016 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 SUPERFAMILY SSF55681 116 293 2.59E-102 T 21-04-2016 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Gene3D G3DSA:3.30.930.10 410 580 1.2E-110 T 21-04-2016 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 Gene3D G3DSA:3.30.930.10 135 277 1.2E-110 T 21-04-2016 SPH21_RS05565 13f6d7b9f6b84d90cc8c8a487b18b816 583 SUPERFAMILY SSF50249 1 105 5.14E-28 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 Gene3D G3DSA:1.10.10.10 11 84 1.4E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 PANTHER PTHR38445 10 295 2.6E-12 T 21-04-2016 SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 SUPERFAMILY SSF46785 14 87 8.91E-15 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 SUPERFAMILY SSF53822 121 342 2.78E-16 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 PANTHER PTHR38445:SF1 10 295 2.6E-12 T 21-04-2016 SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 SMART SM00345 24 83 9.6E-5 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 Gene3D G3DSA:3.40.50.2300 273 342 1.3E-6 T 21-04-2016 SPH21_RS02160 e5a6c94ce7e8d1812a71013d6eed6b7c 343 Pfam PF00392 Bacterial regulatory proteins, gntR family 21 83 3.8E-7 T 21-04-2016 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SPH21_RS06660 5b7ac406c360f500b6cb7a0d6299cf57 363 Pfam PF14362 Domain of unknown function (DUF4407) 19 321 2.1E-91 T 21-04-2016 IPR025519 Protein of unknown function DUF4407 SPH21_RS01900 7e314844da99eb29509cb39f58851936 553 PANTHER PTHR35148 1 553 1.2E-101 T 21-04-2016 SPH21_RS01900 7e314844da99eb29509cb39f58851936 553 PANTHER PTHR35148:SF8 1 553 1.2E-101 T 21-04-2016 SPH21_RS01900 7e314844da99eb29509cb39f58851936 553 Pfam PF12741 Susd and RagB outer membrane lipoprotein 1 548 6.3E-166 T 21-04-2016 IPR024302 SusD-like SPH21_RS01900 7e314844da99eb29509cb39f58851936 553 SUPERFAMILY SSF48452 24 549 8.85E-149 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06780 6e7997895823e6ca7947f19e7df395fc 247 SUPERFAMILY SSF57997 13 91 4.25E-5 T 21-04-2016 SPH21_RS06780 6e7997895823e6ca7947f19e7df395fc 247 Pfam PF02591 C4-type zinc ribbon domain 204 235 6.5E-12 T 21-04-2016 IPR003743 C4-type zinc ribbon domain SPH21_RS06780 6e7997895823e6ca7947f19e7df395fc 247 PANTHER PTHR39082 5 247 4.3E-26 T 21-04-2016 SPH21_RS24255 318c6eacf4ffc3dcf6a9f2f384a69f71 579 Gene3D G3DSA:3.40.30.10 132 313 3.8E-21 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS24255 318c6eacf4ffc3dcf6a9f2f384a69f71 579 Pfam PF00578 AhpC/TSA family 190 260 7.6E-9 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS24255 318c6eacf4ffc3dcf6a9f2f384a69f71 579 SUPERFAMILY SSF52833 164 302 3.35E-18 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS24255 318c6eacf4ffc3dcf6a9f2f384a69f71 579 Pfam PF12543 Protein of unknown function (DUF3738) 446 577 1.0E-4 T 21-04-2016 IPR017801 Soil-associated protein DUF3738 SPH21_RS20935 25b18a372f096cb6ae81ba191ef720d1 189 PANTHER PTHR24567:SF33 14 188 3.3E-17 T 21-04-2016 SPH21_RS20935 25b18a372f096cb6ae81ba191ef720d1 189 PANTHER PTHR24567 14 188 3.3E-17 T 21-04-2016 SPH21_RS20935 25b18a372f096cb6ae81ba191ef720d1 189 SUPERFAMILY SSF51206 16 143 1.96E-25 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS20935 25b18a372f096cb6ae81ba191ef720d1 189 Pfam PF00027 Cyclic nucleotide-binding domain 30 116 4.3E-10 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS20935 25b18a372f096cb6ae81ba191ef720d1 189 Gene3D G3DSA:2.60.120.10 2 155 4.6E-33 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 PANTHER PTHR11014 8 100 5.1E-154 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 PANTHER PTHR11014 141 420 5.1E-154 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 Gene3D G3DSA:3.30.70.360 220 330 3.0E-32 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 SUPERFAMILY SSF53187 12 220 4.19E-68 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 SUPERFAMILY SSF53187 333 415 4.19E-68 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 PANTHER PTHR11014:SF3 8 100 5.1E-154 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 PANTHER PTHR11014:SF3 141 420 5.1E-154 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 Pfam PF01546 Peptidase family M20/M25/M40 149 411 1.7E-11 T 21-04-2016 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 PIRSF PIRSF037215 8 419 9.0E-163 T 21-04-2016 IPR010161 Peptidase M20B, tripeptide aminopeptidase GO:0005737|GO:0006518|GO:0008270|GO:0045148 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 Gene3D G3DSA:3.40.630.10 333 418 8.8E-106 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 Gene3D G3DSA:3.40.630.10 11 219 8.8E-106 T 21-04-2016 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 Pfam PF07687 Peptidase dimerisation domain 221 313 8.0E-10 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 ProSitePatterns PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 148 187 - T 21-04-2016 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 SUPERFAMILY SSF55031 219 330 2.25E-28 T 21-04-2016 IPR011650 Peptidase M20, dimerisation domain SPH21_RS06790 1056e46219e4c4f10970c5f4f815c738 422 TIGRFAM TIGR01882 peptidase-T: peptidase T 12 416 1.2E-134 T 21-04-2016 IPR010161 Peptidase M20B, tripeptide aminopeptidase GO:0005737|GO:0006518|GO:0008270|GO:0045148 SPH21_RS05490 5d2761fdd234864b4211e5fe4987bdcd 323 PANTHER PTHR12001:SF47 3 323 1.1E-88 T 21-04-2016 SPH21_RS05490 5d2761fdd234864b4211e5fe4987bdcd 323 Gene3D G3DSA:1.10.600.10 4 323 9.4E-92 T 21-04-2016 IPR008949 Isoprenoid synthase domain SPH21_RS05490 5d2761fdd234864b4211e5fe4987bdcd 323 SUPERFAMILY SSF48576 6 322 9.0E-82 T 21-04-2016 IPR008949 Isoprenoid synthase domain SPH21_RS05490 5d2761fdd234864b4211e5fe4987bdcd 323 PANTHER PTHR12001 3 323 1.1E-88 T 21-04-2016 IPR017446 Polyprenyl synthetase-related SPH21_RS05490 5d2761fdd234864b4211e5fe4987bdcd 323 Pfam PF00348 Polyprenyl synthetase 32 273 8.7E-62 T 21-04-2016 IPR000092 Polyprenyl synthetase GO:0008299 SPH21_RS05490 5d2761fdd234864b4211e5fe4987bdcd 323 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 204 216 - T 21-04-2016 IPR000092 Polyprenyl synthetase GO:0008299 SPH21_RS05490 5d2761fdd234864b4211e5fe4987bdcd 323 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 82 96 - T 21-04-2016 IPR000092 Polyprenyl synthetase GO:0008299 SPH21_RS20345 f9a331dff065169cbe535f1584f63f90 285 Pfam PF01734 Patatin-like phospholipase 7 163 7.3E-21 T 21-04-2016 IPR002641 Patatin/Phospholipase A2-related GO:0006629 SPH21_RS20345 f9a331dff065169cbe535f1584f63f90 285 PANTHER PTHR14226:SF24 5 261 8.9E-73 T 21-04-2016 SPH21_RS20345 f9a331dff065169cbe535f1584f63f90 285 PANTHER PTHR14226 5 261 8.9E-73 T 21-04-2016 SPH21_RS20345 f9a331dff065169cbe535f1584f63f90 285 SUPERFAMILY SSF52151 4 255 1.41E-46 T 21-04-2016 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SPH21_RS20345 f9a331dff065169cbe535f1584f63f90 285 Gene3D G3DSA:3.40.1090.10 7 161 1.0E-11 T 21-04-2016 SPH21_RS03780 a09977a733fcc47f253307e1407de1ff 227 SUPERFAMILY SSF54106 185 227 5.89E-11 T 21-04-2016 IPR018392 LysM domain SPH21_RS03780 a09977a733fcc47f253307e1407de1ff 227 SMART SM00047 18 159 6.9E-6 T 21-04-2016 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SPH21_RS03780 a09977a733fcc47f253307e1407de1ff 227 Gene3D G3DSA:3.10.350.10 185 227 4.6E-17 T 21-04-2016 IPR018392 LysM domain SPH21_RS03780 a09977a733fcc47f253307e1407de1ff 227 SMART SM00257 185 227 8.1E-11 T 21-04-2016 IPR018392 LysM domain SPH21_RS03780 a09977a733fcc47f253307e1407de1ff 227 Pfam PF01832 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase 35 154 2.4E-19 T 21-04-2016 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SPH21_RS03780 a09977a733fcc47f253307e1407de1ff 227 Gene3D G3DSA:1.10.530.10 26 62 8.4E-4 T 21-04-2016 SPH21_RS03780 a09977a733fcc47f253307e1407de1ff 227 Pfam PF01476 LysM domain 186 227 1.7E-14 T 21-04-2016 IPR018392 LysM domain SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 PANTHER PTHR24421 210 711 6.4E-34 T 21-04-2016 SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 Gene3D G3DSA:1.25.40.10 283 461 9.9E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 626 711 6.0E-9 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 SUPERFAMILY SSF48452 85 224 2.47E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 Gene3D G3DSA:1.25.40.10 86 226 2.9E-6 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 Gene3D G3DSA:3.30.565.10 598 712 1.1E-13 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 SMART SM00387 621 714 4.3E-5 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 Pfam PF07730 Histidine kinase 519 582 9.2E-12 T 21-04-2016 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 SUPERFAMILY SSF48452 342 457 5.77E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 SUPERFAMILY SSF55874 590 710 1.1E-20 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS26450 a08a1ed3918670ec7eca6fabf2725ba1 715 PANTHER PTHR24421:SF23 210 711 6.4E-34 T 21-04-2016 SPH21_RS14515 bafb32abc41cbefe8fc3b7f589b8dffd 499 Pfam PF03321 GH3 auxin-responsive promoter 189 488 2.6E-56 T 21-04-2016 IPR004993 GH3 family KEGG: 00220+6.3.2.-|KEGG: 00261+6.3.2.-|KEGG: 00380+6.3.2.- SPH21_RS14515 bafb32abc41cbefe8fc3b7f589b8dffd 499 Pfam PF03321 GH3 auxin-responsive promoter 19 179 2.1E-32 T 21-04-2016 IPR004993 GH3 family KEGG: 00220+6.3.2.-|KEGG: 00261+6.3.2.-|KEGG: 00380+6.3.2.- SPH21_RS14515 bafb32abc41cbefe8fc3b7f589b8dffd 499 PANTHER PTHR31901 25 499 6.8E-53 T 21-04-2016 IPR004993 GH3 family KEGG: 00220+6.3.2.-|KEGG: 00261+6.3.2.-|KEGG: 00380+6.3.2.- SPH21_RS14515 bafb32abc41cbefe8fc3b7f589b8dffd 499 PANTHER PTHR31901:SF5 25 499 6.8E-53 T 21-04-2016 SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 SUPERFAMILY SSF53335 155 223 6.69E-35 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 SUPERFAMILY SSF53335 261 379 6.69E-35 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 PANTHER PTHR14911 9 218 9.9E-38 T 21-04-2016 SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 PANTHER PTHR14911 258 378 9.9E-38 T 21-04-2016 SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 Pfam PF01170 Putative RNA methylase family UPF0020 169 374 1.6E-44 T 21-04-2016 IPR000241 Putative RNA methylase domain KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 PANTHER PTHR14911:SF13 9 218 9.9E-38 T 21-04-2016 SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 PANTHER PTHR14911:SF13 258 378 9.9E-38 T 21-04-2016 SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 Gene3D G3DSA:3.40.50.150 258 377 3.8E-26 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS06550 8c6dcb4ff67d55d6259f0d2402e5bd7f 391 Gene3D G3DSA:3.40.50.150 152 220 3.8E-26 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS26305 770b036294ac44b91edd2b4b9b57d478 193 PANTHER PTHR34584:SF2 52 184 1.7E-22 T 21-04-2016 SPH21_RS26305 770b036294ac44b91edd2b4b9b57d478 193 PANTHER PTHR34584 52 184 1.7E-22 T 21-04-2016 SPH21_RS26305 770b036294ac44b91edd2b4b9b57d478 193 Pfam PF01899 Na+/H+ ion antiporter subunit 17 163 6.1E-30 T 21-04-2016 IPR002758 Na+/H+ antiporter subunit E GO:0006812|GO:0008324|GO:0016021 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 SUPERFAMILY SSF56420 1 173 6.28E-55 T 21-04-2016 IPR023635 Peptide deformylase SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 PIRSF PIRSF004749 1 184 6.6E-54 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 PANTHER PTHR10458 3 182 4.0E-60 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 PRINTS PR01576 Peptide deformylase signature 128 157 2.7E-30 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 PRINTS PR01576 Peptide deformylase signature 32 61 2.7E-30 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 PRINTS PR01576 Peptide deformylase signature 97 108 2.7E-30 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 PRINTS PR01576 Peptide deformylase signature 109 127 2.7E-30 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 5 166 1.6E-40 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 Hamap MF_00163 Peptide deformylase [def]. 1 170 27.3 T 21-04-2016 IPR000181 Formylmethionine deformylase GO:0005506|GO:0042586 SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 Gene3D G3DSA:3.90.45.10 3 184 2.5E-61 T 21-04-2016 IPR023635 Peptide deformylase SPH21_RS05715 b296fe7447bc1c6206ee3567b3cd3d27 190 Pfam PF01327 Polypeptide deformylase 4 158 7.9E-50 T 21-04-2016 IPR023635 Peptide deformylase SPH21_RS13610 b4898f9d3c457f298b1a2deb615634ac 249 PANTHER PTHR10108:SF855 41 239 1.0E-22 T 21-04-2016 SPH21_RS13610 b4898f9d3c457f298b1a2deb615634ac 249 Pfam PF13649 Methyltransferase domain 43 137 7.0E-17 T 21-04-2016 SPH21_RS13610 b4898f9d3c457f298b1a2deb615634ac 249 Gene3D G3DSA:3.40.50.150 17 187 2.8E-28 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS13610 b4898f9d3c457f298b1a2deb615634ac 249 PANTHER PTHR10108 41 239 1.0E-22 T 21-04-2016 SPH21_RS13610 b4898f9d3c457f298b1a2deb615634ac 249 SUPERFAMILY SSF53335 41 248 5.47E-34 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS16165 047ccac37fae9ec817cb4e15218f54ec 74 Gene3D G3DSA:3.30.1660.10 3 67 8.7E-23 T 21-04-2016 IPR025543 Dodecin-like SPH21_RS16165 047ccac37fae9ec817cb4e15218f54ec 74 Pfam PF07311 Dodecin 4 66 3.6E-24 T 21-04-2016 IPR009923 Dodecin SPH21_RS16165 047ccac37fae9ec817cb4e15218f54ec 74 SUPERFAMILY SSF89807 2 66 2.09E-20 T 21-04-2016 IPR009923 Dodecin SPH21_RS24040 4e811bff7485680478f2f6098c4b08f8 223 SUPERFAMILY SSF81343 5 222 6.1E-35 T 21-04-2016 SPH21_RS24040 4e811bff7485680478f2f6098c4b08f8 223 Gene3D G3DSA:1.20.950.10 19 215 5.0E-6 T 21-04-2016 SPH21_RS24040 4e811bff7485680478f2f6098c4b08f8 223 TIGRFAM TIGR02046 sdhC_b558_fam: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family 10 220 5.3E-47 T 21-04-2016 IPR011138 Succinate dehydrogenase cytochrome b558 subunit UniPathway: UPA00223 SPH21_RS21860 ee301e056e888f31b4f300427813afbc 410 SUPERFAMILY SSF48208 45 404 2.08E-99 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS21860 ee301e056e888f31b4f300427813afbc 410 PANTHER PTHR36845 4 404 1.0E-93 T 21-04-2016 SPH21_RS21860 ee301e056e888f31b4f300427813afbc 410 Gene3D G3DSA:1.50.10.10 42 406 6.6E-140 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS21860 ee301e056e888f31b4f300427813afbc 410 PANTHER PTHR36845:SF1 4 404 1.0E-93 T 21-04-2016 SPH21_RS21860 ee301e056e888f31b4f300427813afbc 410 Pfam PF07470 Glycosyl Hydrolase Family 88 76 378 1.2E-18 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS25015 a38da45c383feafd29fd9caec19f8024 324 SUPERFAMILY SSF75005 39 316 3.27E-40 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS25015 a38da45c383feafd29fd9caec19f8024 324 Gene3D G3DSA:2.115.10.20 40 317 5.0E-34 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS25015 a38da45c383feafd29fd9caec19f8024 324 Pfam PF04616 Glycosyl hydrolases family 43 40 302 2.3E-14 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02610 e1326aa0307526a94d3fab2d0bacae50 318 Pfam PF00892 EamA-like transporter family 162 302 8.5E-22 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS02610 e1326aa0307526a94d3fab2d0bacae50 318 Pfam PF00892 EamA-like transporter family 13 144 1.1E-13 T 21-04-2016 IPR000620 EamA domain GO:0016020|GO:0016021 SPH21_RS02610 e1326aa0307526a94d3fab2d0bacae50 318 PANTHER PTHR32322 1 301 5.0E-64 T 21-04-2016 SPH21_RS02610 e1326aa0307526a94d3fab2d0bacae50 318 SUPERFAMILY SSF103481 197 304 1.7E-16 T 21-04-2016 SPH21_RS02610 e1326aa0307526a94d3fab2d0bacae50 318 PANTHER PTHR32322:SF8 1 301 5.0E-64 T 21-04-2016 SPH21_RS02610 e1326aa0307526a94d3fab2d0bacae50 318 SUPERFAMILY SSF103481 45 145 7.72E-9 T 21-04-2016 SPH21_RS08575 508dd0d73c6e0851ceb796956d54d8ef 117 TIGRFAM TIGR00060 L18_bact: ribosomal protein uL18 7 117 3.5E-40 T 21-04-2016 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08575 508dd0d73c6e0851ceb796956d54d8ef 117 Hamap MF_01337_B 50S ribosomal protein L18 [rplR]. 4 117 27.159 T 21-04-2016 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08575 508dd0d73c6e0851ceb796956d54d8ef 117 Gene3D G3DSA:3.30.420.100 23 117 2.5E-39 T 21-04-2016 SPH21_RS08575 508dd0d73c6e0851ceb796956d54d8ef 117 SUPERFAMILY SSF53137 5 115 1.02E-48 T 21-04-2016 SPH21_RS08575 508dd0d73c6e0851ceb796956d54d8ef 117 Pfam PF00861 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast 5 117 2.8E-44 T 21-04-2016 IPR005484 Ribosomal protein L18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08575 508dd0d73c6e0851ceb796956d54d8ef 117 PANTHER PTHR12899 16 117 9.5E-40 T 21-04-2016 SPH21_RS02980 6e6aa62cc41cfbeac1e6b3f81ca67591 684 SUPERFAMILY SSF48208 104 357 2.93E-17 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02980 6e6aa62cc41cfbeac1e6b3f81ca67591 684 PANTHER PTHR31151 54 683 2.8E-207 T 21-04-2016 SPH21_RS02980 6e6aa62cc41cfbeac1e6b3f81ca67591 684 PANTHER PTHR31151:SF4 54 683 2.8E-207 T 21-04-2016 SPH21_RS02980 6e6aa62cc41cfbeac1e6b3f81ca67591 684 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 36 549 4.3E-100 T 21-04-2016 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS18215 3ee0a4c3a60ae295546c4f8c7795549f 440 PANTHER PTHR21666:SF221 152 380 4.9E-58 T 21-04-2016 SPH21_RS18215 3ee0a4c3a60ae295546c4f8c7795549f 440 Pfam PF01551 Peptidase family M23 291 384 1.2E-29 T 21-04-2016 IPR016047 Peptidase M23 SPH21_RS18215 3ee0a4c3a60ae295546c4f8c7795549f 440 Gene3D G3DSA:2.70.70.10 246 386 1.3E-41 T 21-04-2016 SPH21_RS18215 3ee0a4c3a60ae295546c4f8c7795549f 440 SUPERFAMILY SSF51261 137 386 9.42E-59 T 21-04-2016 IPR011055 Duplicated hybrid motif SPH21_RS18215 3ee0a4c3a60ae295546c4f8c7795549f 440 PANTHER PTHR21666 152 380 4.9E-58 T 21-04-2016 SPH21_RS04095 bcaded616332297460b07c00fbba3689 461 PANTHER PTHR12053 50 458 2.3E-108 T 21-04-2016 SPH21_RS04095 bcaded616332297460b07c00fbba3689 461 PANTHER PTHR12053:SF3 50 458 2.3E-108 T 21-04-2016 SPH21_RS04095 bcaded616332297460b07c00fbba3689 461 Pfam PF04389 Peptidase family M28 264 384 3.7E-18 T 21-04-2016 IPR007484 Peptidase M28 SPH21_RS04095 bcaded616332297460b07c00fbba3689 461 Gene3D G3DSA:3.40.630.10 263 452 6.8E-49 T 21-04-2016 SPH21_RS04095 bcaded616332297460b07c00fbba3689 461 Gene3D G3DSA:3.40.630.10 41 98 6.8E-49 T 21-04-2016 SPH21_RS04095 bcaded616332297460b07c00fbba3689 461 SUPERFAMILY SSF53187 208 455 7.11E-44 T 21-04-2016 SPH21_RS19580 b038cc9ae8f83318dadd3ab95f404f85 77 Pfam PF01954 Protein of unknown function DUF104 1 34 2.3E-5 T 21-04-2016 IPR008203 Uncharacterised protein family UPF0165 SPH21_RS19580 b038cc9ae8f83318dadd3ab95f404f85 77 Gene3D G3DSA:4.10.1150.10 1 31 2.6E-5 T 21-04-2016 IPR024069 AF2212-like domain SPH21_RS19580 b038cc9ae8f83318dadd3ab95f404f85 77 SUPERFAMILY SSF141694 1 40 4.45E-6 T 21-04-2016 SPH21_RS04640 5222c76697959a627bd450b29005f2c7 323 PANTHER PTHR11732 4 307 1.6E-95 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS04640 5222c76697959a627bd450b29005f2c7 323 PANTHER PTHR11732:SF12 4 307 1.6E-95 T 21-04-2016 SPH21_RS04640 5222c76697959a627bd450b29005f2c7 323 Pfam PF00248 Aldo/keto reductase family 18 309 3.4E-60 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS04640 5222c76697959a627bd450b29005f2c7 323 Gene3D G3DSA:3.20.20.100 4 315 5.6E-89 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS04640 5222c76697959a627bd450b29005f2c7 323 SUPERFAMILY SSF51430 7 309 5.24E-81 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS08780 0d2daf259e8061ef1aadaf5aabcc8338 471 Gene3D G3DSA:1.25.40.10 210 420 1.9E-23 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08780 0d2daf259e8061ef1aadaf5aabcc8338 471 Pfam PF07980 SusD family 278 432 5.1E-20 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS08780 0d2daf259e8061ef1aadaf5aabcc8338 471 Pfam PF14322 Starch-binding associating with outer membrane 16 225 5.6E-21 T 21-04-2016 SPH21_RS08780 0d2daf259e8061ef1aadaf5aabcc8338 471 SUPERFAMILY SSF48452 11 471 2.15E-85 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03950 fd724eb52291c83b3d0228e08a6c2a7d 328 Pfam PF16344 Domain of unknown function (DUF4974) 226 326 4.8E-24 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS03950 fd724eb52291c83b3d0228e08a6c2a7d 328 PANTHER PTHR30273:SF2 7 327 2.1E-75 T 21-04-2016 SPH21_RS03950 fd724eb52291c83b3d0228e08a6c2a7d 328 PANTHER PTHR30273 7 327 2.1E-75 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS03950 fd724eb52291c83b3d0228e08a6c2a7d 328 PIRSF PIRSF018266 2 328 6.2E-64 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS03950 fd724eb52291c83b3d0228e08a6c2a7d 328 Pfam PF04773 FecR protein 121 216 9.0E-18 T 21-04-2016 IPR006860 FecR protein SPH21_RS07800 a32b9f7cb15f1d7a41363f14cbbbf636 244 SUPERFAMILY SSF69593 15 229 7.59E-26 T 21-04-2016 SPH21_RS07800 a32b9f7cb15f1d7a41363f14cbbbf636 244 Pfam PF01553 Acyltransferase 63 192 2.0E-18 T 21-04-2016 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SPH21_RS07800 a32b9f7cb15f1d7a41363f14cbbbf636 244 PANTHER PTHR10434 7 237 2.5E-33 T 21-04-2016 SPH21_RS07800 a32b9f7cb15f1d7a41363f14cbbbf636 244 Gene3D G3DSA:3.40.1130.10 64 235 2.8E-14 T 21-04-2016 SPH21_RS07800 a32b9f7cb15f1d7a41363f14cbbbf636 244 SMART SM00563 76 195 3.2E-17 T 21-04-2016 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SPH21_RS13480 b97773396f8b22f84c30a33b5bab006a 318 Gene3D G3DSA:3.40.50.300 3 226 1.6E-65 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13480 b97773396f8b22f84c30a33b5bab006a 318 SUPERFAMILY SSF52540 4 226 2.56E-60 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13480 b97773396f8b22f84c30a33b5bab006a 318 SMART SM00382 29 213 4.2E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS13480 b97773396f8b22f84c30a33b5bab006a 318 PANTHER PTHR24220:SF480 6 223 6.3E-125 T 21-04-2016 SPH21_RS13480 b97773396f8b22f84c30a33b5bab006a 318 PANTHER PTHR24220 6 223 6.3E-125 T 21-04-2016 SPH21_RS13480 b97773396f8b22f84c30a33b5bab006a 318 Pfam PF00005 ABC transporter 21 163 1.7E-29 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS16805 3757e5e6903bc760fbcbe5062888c684 372 PANTHER PTHR21716 8 352 1.9E-53 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS16805 3757e5e6903bc760fbcbe5062888c684 372 Pfam PF01594 Domain of unknown function DUF20 16 334 5.2E-49 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 Pfam PF00873 AcrB/AcrD/AcrF family 17 625 2.1E-123 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 PANTHER PTHR32063:SF19 4 644 7.3E-271 T 21-04-2016 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 PANTHER PTHR32063 4 644 7.3E-271 T 21-04-2016 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 SUPERFAMILY SSF82866 19 90 1.83E-11 T 21-04-2016 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 Gene3D G3DSA:1.10.3850.10 401 625 6.6E-43 T 21-04-2016 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 Gene3D G3DSA:1.10.3850.10 19 92 2.6E-17 T 21-04-2016 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 PRINTS PR00702 Acriflavin resistance protein family signature 63 86 7.4E-6 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 PRINTS PR00702 Acriflavin resistance protein family signature 137 154 7.4E-6 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 PRINTS PR00702 Acriflavin resistance protein family signature 38 61 7.4E-6 T 21-04-2016 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 SUPERFAMILY SSF82714 308 392 2.35E-17 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 SUPERFAMILY SSF82866 391 628 2.35E-39 T 21-04-2016 SPH21_RS13950 b4ebf19a2a4cbfcc39bf2a591834111a 644 Gene3D G3DSA:3.30.2090.10 309 392 2.2E-19 T 21-04-2016 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains SPH21_RS00430 394f4ddc20b4a8195921b74d9b5e496b 410 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system 27 322 2.2E-13 T 21-04-2016 IPR003959 ATPase, AAA-type, core GO:0005524 SPH21_RS00430 394f4ddc20b4a8195921b74d9b5e496b 410 Gene3D G3DSA:3.40.50.300 2 339 2.9E-14 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00430 394f4ddc20b4a8195921b74d9b5e496b 410 SUPERFAMILY SSF52540 254 323 1.63E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS00430 394f4ddc20b4a8195921b74d9b5e496b 410 SUPERFAMILY SSF52540 21 162 1.63E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS26320 d5fc996588c4ed978e1b519582ea6247 493 PANTHER PTHR30572:SF4 98 493 2.3E-60 T 21-04-2016 SPH21_RS26320 d5fc996588c4ed978e1b519582ea6247 493 PANTHER PTHR30572:SF4 1 53 2.3E-60 T 21-04-2016 SPH21_RS26320 d5fc996588c4ed978e1b519582ea6247 493 Pfam PF02687 FtsX-like permease family 372 484 2.1E-12 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS26320 d5fc996588c4ed978e1b519582ea6247 493 Pfam PF02687 FtsX-like permease family 7 103 8.4E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS26320 d5fc996588c4ed978e1b519582ea6247 493 PANTHER PTHR30572 98 493 2.3E-60 T 21-04-2016 SPH21_RS26320 d5fc996588c4ed978e1b519582ea6247 493 PANTHER PTHR30572 1 53 2.3E-60 T 21-04-2016 SPH21_RS14345 92cf2bc887dd919a28ba7ad0e7bfab02 332 Gene3D G3DSA:2.160.20.10 25 330 5.0E-114 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS14345 92cf2bc887dd919a28ba7ad0e7bfab02 332 Pfam PF01095 Pectinesterase 30 319 9.9E-81 T 21-04-2016 IPR000070 Pectinesterase, catalytic GO:0005618|GO:0030599|GO:0042545 KEGG: 00040+3.1.1.11|KEGG: 00500+3.1.1.11|MetaCyc: PWY-1081|MetaCyc: PWY-7246|MetaCyc: PWY-7248|UniPathway: UPA00545 SPH21_RS14345 92cf2bc887dd919a28ba7ad0e7bfab02 332 PANTHER PTHR31321 26 324 7.9E-118 T 21-04-2016 SPH21_RS14345 92cf2bc887dd919a28ba7ad0e7bfab02 332 PANTHER PTHR31321:SF1 26 324 7.9E-118 T 21-04-2016 SPH21_RS14345 92cf2bc887dd919a28ba7ad0e7bfab02 332 SUPERFAMILY SSF51126 24 328 5.95E-84 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS14345 92cf2bc887dd919a28ba7ad0e7bfab02 332 ProSitePatterns PS00503 Pectinesterase signature 2. 185 194 - T 21-04-2016 IPR033131 Pectinesterase, Asp active site KEGG: 00040+3.1.1.11|KEGG: 00500+3.1.1.11|MetaCyc: PWY-1081|MetaCyc: PWY-7246|MetaCyc: PWY-7248|UniPathway: UPA00545 SPH21_RS06900 19371748e2dc5a169e94efacbc58548c 542 PANTHER PTHR33446 426 537 3.2E-15 T 21-04-2016 SPH21_RS06900 19371748e2dc5a169e94efacbc58548c 542 SUPERFAMILY SSF74653 445 523 7.19E-15 T 21-04-2016 SPH21_RS06900 19371748e2dc5a169e94efacbc58548c 542 Pfam PF03544 Gram-negative bacterial TonB protein C-terminal 449 523 1.6E-15 T 21-04-2016 IPR006260 TonB, C-terminal GO:0006810 SPH21_RS06900 19371748e2dc5a169e94efacbc58548c 542 Pfam PF05569 BlaR1 peptidase M56 145 241 2.0E-12 T 21-04-2016 IPR008756 Peptidase M56 SPH21_RS22395 dca56ef04f821ff5444f6387b2e183b6 124 PANTHER PTHR33204 8 112 8.0E-24 T 21-04-2016 SPH21_RS22395 dca56ef04f821ff5444f6387b2e183b6 124 Gene3D G3DSA:1.10.10.10 22 114 2.1E-25 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22395 dca56ef04f821ff5444f6387b2e183b6 124 Pfam PF01638 HxlR-like helix-turn-helix 30 115 2.7E-21 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS22395 dca56ef04f821ff5444f6387b2e183b6 124 SUPERFAMILY SSF46785 19 113 3.39E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 Gene3D G3DSA:1.25.40.20 38 221 1.4E-42 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 SMART SM00248 95 124 1.3 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 SMART SM00248 162 196 150.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 SMART SM00248 62 91 2.4 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 SMART SM00248 128 158 840.0 T 21-04-2016 IPR002110 Ankyrin repeat GO:0005515 SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 Pfam PF12796 Ankyrin repeats (3 copies) 102 197 9.1E-12 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 SUPERFAMILY SSF48403 38 221 5.5E-44 T 21-04-2016 IPR020683 Ankyrin repeat-containing domain SPH21_RS09505 ea2a6d91de7c58ce7f92cc66af2d5dd1 222 PANTHER PTHR24198 34 220 7.4E-43 T 21-04-2016 SPH21_RS15620 587d024d453f7c0af018c611501c27d8 134 Gene3D G3DSA:2.40.50.140 36 116 7.3E-11 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS15620 587d024d453f7c0af018c611501c27d8 134 Pfam PF03100 CcmE 6 120 4.2E-18 T 21-04-2016 IPR004329 CcmE/CycJ protein GO:0005886|GO:0017003|GO:0017004 SPH21_RS15620 587d024d453f7c0af018c611501c27d8 134 SUPERFAMILY SSF82093 27 125 2.22E-16 T 21-04-2016 IPR004329 CcmE/CycJ protein GO:0005886|GO:0017003|GO:0017004 SPH21_RS04460 5337b821abdbddcc26359d2fc3726f0d 139 Pfam PF07681 DoxX 11 100 4.7E-7 T 21-04-2016 IPR032808 DoxX family SPH21_RS22185 2b342a95e083977268d964d4bd470a12 489 Pfam PF14903 WG containing repeat 68 86 0.0055 T 21-04-2016 IPR032774 WG containing repeat SPH21_RS15010 8c1e4efc695e0c42cbbcdf16e99d5271 280 PANTHER PTHR23200:SF41 1 278 2.4E-55 T 21-04-2016 SPH21_RS15010 8c1e4efc695e0c42cbbcdf16e99d5271 280 PANTHER PTHR23200 1 278 2.4E-55 T 21-04-2016 SPH21_RS15010 8c1e4efc695e0c42cbbcdf16e99d5271 280 Gene3D G3DSA:3.60.15.10 3 268 9.1E-40 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS15010 8c1e4efc695e0c42cbbcdf16e99d5271 280 SUPERFAMILY SSF56281 1 268 1.83E-36 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS15010 8c1e4efc695e0c42cbbcdf16e99d5271 280 SMART SM00849 42 245 9.5E-13 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS15010 8c1e4efc695e0c42cbbcdf16e99d5271 280 Pfam PF00753 Metallo-beta-lactamase superfamily 47 238 7.0E-17 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 Pfam PF00361 Proton-conducting membrane transporter 139 426 3.0E-91 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 361 383 3.0E-14 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 88 108 3.0E-14 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 418 440 3.0E-14 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 62 86 3.0E-14 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 TIGRFAM TIGR01974 NDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L 5 632 6.7E-229 T 21-04-2016 IPR003945 NADH-plastoquinone oxidoreductase, chain 5 GO:0008137|GO:0042773|GO:0055114 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 69 125 5.4E-26 T 21-04-2016 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 250 276 2.5E-63 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 228 249 2.5E-63 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 161 182 2.5E-63 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 318 330 2.5E-63 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 114 134 2.5E-63 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 86 111 2.5E-63 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 419 438 2.5E-63 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PANTHER PTHR22773 1 588 7.2E-244 T 21-04-2016 SPH21_RS07910 6c2998e7cff23317d4fb90f2071cc100 637 PANTHER PTHR22773:SF50 1 588 7.2E-244 T 21-04-2016 SPH21_RS26310 cd6879953ec5e8c40e2068428b26da50 296 Gene3D G3DSA:1.10.10.60 249 294 7.6E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26310 cd6879953ec5e8c40e2068428b26da50 296 Pfam PF12833 Helix-turn-helix domain 215 293 3.4E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26310 cd6879953ec5e8c40e2068428b26da50 296 PANTHER PTHR11019:SF80 43 294 7.6E-49 T 21-04-2016 SPH21_RS26310 cd6879953ec5e8c40e2068428b26da50 296 SUPERFAMILY SSF46689 248 294 2.69E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS26310 cd6879953ec5e8c40e2068428b26da50 296 SMART SM00342 209 292 1.1E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS26310 cd6879953ec5e8c40e2068428b26da50 296 PANTHER PTHR11019 43 294 7.6E-49 T 21-04-2016 SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 Gene3D G3DSA:3.20.20.120 184 454 1.1E-72 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 SUPERFAMILY SSF54826 78 179 4.72E-19 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 Pfam PF13378 Enolase C-terminal domain-like 264 467 3.7E-41 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 PANTHER PTHR13794 268 498 7.8E-75 T 21-04-2016 IPR001354 Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase GO:0003824|GO:0008152 SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 PANTHER PTHR13794 55 219 7.8E-75 T 21-04-2016 IPR001354 Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase GO:0003824|GO:0008152 SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 SMART SM00922 198 344 2.2E-5 T 21-04-2016 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 88 179 2.1E-11 T 21-04-2016 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 SUPERFAMILY SSF51604 167 475 4.06E-63 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 Gene3D G3DSA:3.30.390.10 78 183 2.0E-29 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 PANTHER PTHR13794:SF4 268 498 7.8E-75 T 21-04-2016 SPH21_RS13770 cf507f959989498d2c8f6052052a19c9 498 PANTHER PTHR13794:SF4 55 219 7.8E-75 T 21-04-2016 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 PANTHER PTHR11108 228 338 6.1E-100 T 21-04-2016 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|UniPathway: UPA00252 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 PANTHER PTHR11108 1 206 6.1E-100 T 21-04-2016 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|UniPathway: UPA00252 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 SUPERFAMILY SSF53800 1 348 8.6E-91 T 21-04-2016 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 Pfam PF00762 Ferrochelatase 4 339 4.7E-100 T 21-04-2016 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|UniPathway: UPA00252 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 Gene3D G3DSA:3.40.50.1400 3 204 1.2E-51 T 21-04-2016 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 Gene3D G3DSA:3.40.50.1400 221 338 2.1E-35 T 21-04-2016 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 TIGRFAM TIGR00109 hemH: ferrochelatase 2 339 1.6E-78 T 21-04-2016 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|UniPathway: UPA00252 SPH21_RS05260 c66305351804efae0bb414cfd3779df5 356 Hamap MF_00323 Ferrochelatase [hemH]. 3 341 33.852 T 21-04-2016 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|UniPathway: UPA00252 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Gene3D G3DSA:2.170.130.10 110 222 5.3E-25 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Gene3D G3DSA:2.60.40.1120 24 109 1.2E-11 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Pfam PF13715 CarboxypepD_reg-like domain 24 106 4.8E-17 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 198 228 4.0E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Pfam PF07715 TonB-dependent Receptor Plug Domain 114 222 5.7E-25 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Gene3D G3DSA:2.40.170.20 865 890 3.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Gene3D G3DSA:2.40.170.20 940 1054 3.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Gene3D G3DSA:2.40.170.20 223 242 3.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Gene3D G3DSA:2.40.170.20 425 793 3.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 Gene3D G3DSA:2.40.170.20 325 393 3.6E-51 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 SUPERFAMILY SSF49464 23 104 1.31E-13 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532 573 1004 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532 470 549 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532 1 393 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532 1034 1052 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532:SF57 573 1004 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532:SF57 470 549 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532:SF57 1 393 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 PANTHER PTHR11532:SF57 1034 1052 2.2E-275 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 SUPERFAMILY SSF56935 856 900 3.3E-93 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 SUPERFAMILY SSF56935 446 783 3.3E-93 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 SUPERFAMILY SSF56935 102 246 3.3E-93 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 SUPERFAMILY SSF56935 940 1054 3.3E-93 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 SUPERFAMILY SSF56935 316 404 3.3E-93 T 21-04-2016 SPH21_RS11490 0c02bf85699c1b32fc724d1e0342b05c 1054 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 23 1054 5.7E-277 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 Gene3D G3DSA:3.40.50.720 1 112 1.0E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 PANTHER PTHR10996:SF118 1 315 4.5E-90 T 21-04-2016 SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 SUPERFAMILY SSF52283 1 136 2.46E-21 T 21-04-2016 SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 Gene3D G3DSA:3.40.50.720 113 291 2.8E-56 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 3 316 1.3E-14 T 21-04-2016 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 SUPERFAMILY SSF51735 106 291 6.4E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 PANTHER PTHR10996 1 315 4.5E-90 T 21-04-2016 SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 113 291 4.3E-53 T 21-04-2016 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SPH21_RS02135 d9ba71352b3a33656afddb1315fe3dfd 328 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 200 222 - T 21-04-2016 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 PANTHER PTHR11920 136 346 4.1E-43 T 21-04-2016 SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 PANTHER PTHR11920:SF257 136 346 4.1E-43 T 21-04-2016 SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 Gene3D G3DSA:3.40.50.2300 1 130 6.3E-31 T 21-04-2016 SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 Gene3D G3DSA:3.30.70.1230 168 346 6.5E-47 T 21-04-2016 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 SMART SM00448 2 118 4.1E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 SUPERFAMILY SSF55073 165 346 3.3E-54 T 21-04-2016 IPR029787 Nucleotide cyclase SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 SUPERFAMILY SSF52172 1 132 4.7E-33 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 Pfam PF00211 Adenylate and Guanylate cyclase catalytic domain 167 340 2.5E-32 T 21-04-2016 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 Pfam PF00072 Response regulator receiver domain 4 117 1.7E-24 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS11125 66e4694b2b7030b1d8a90dc6adaabc17 347 SMART SM00044 133 327 1.1E-17 T 21-04-2016 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SPH21_RS05130 3529416715d69ed79d776ba832e77072 196 PANTHER PTHR13610:SF9 41 195 3.0E-58 T 21-04-2016 SPH21_RS05130 3529416715d69ed79d776ba832e77072 196 Pfam PF13847 Methyltransferase domain 66 174 3.3E-14 T 21-04-2016 IPR025714 Methyltransferase domain SPH21_RS05130 3529416715d69ed79d776ba832e77072 196 Gene3D G3DSA:3.40.50.150 53 177 2.8E-28 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05130 3529416715d69ed79d776ba832e77072 196 SUPERFAMILY SSF53335 42 180 1.43E-32 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05130 3529416715d69ed79d776ba832e77072 196 PANTHER PTHR13610 41 195 3.0E-58 T 21-04-2016 IPR026170 FAM173 family SPH21_RS16890 0f83a97e696e7d3de7db2e9132c30aa0 287 SUPERFAMILY SSF103481 188 285 1.44E-6 T 21-04-2016 SPH21_RS09980 55434070e82b7a2c5c7cd76749f12c0b 251 Gene3D G3DSA:3.40.630.30 1 147 1.0E-12 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS09980 55434070e82b7a2c5c7cd76749f12c0b 251 Pfam PF00583 Acetyltransferase (GNAT) family 66 140 7.4E-6 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS09980 55434070e82b7a2c5c7cd76749f12c0b 251 SUPERFAMILY SSF55729 1 150 1.81E-14 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS14265 a918f0a2f9f2ab471d1ede2c5a79f7c5 418 PANTHER PTHR36845:SF1 20 417 4.7E-97 T 21-04-2016 SPH21_RS14265 a918f0a2f9f2ab471d1ede2c5a79f7c5 418 Pfam PF07470 Glycosyl Hydrolase Family 88 94 415 1.1E-22 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS14265 a918f0a2f9f2ab471d1ede2c5a79f7c5 418 Gene3D G3DSA:1.50.10.10 52 417 2.7E-146 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS14265 a918f0a2f9f2ab471d1ede2c5a79f7c5 418 PANTHER PTHR36845 20 417 4.7E-97 T 21-04-2016 SPH21_RS14265 a918f0a2f9f2ab471d1ede2c5a79f7c5 418 SUPERFAMILY SSF48208 87 416 9.3E-107 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 PIRSF PIRSF000077 1 105 7.6E-41 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 SUPERFAMILY SSF52833 3 105 5.41E-41 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 Pfam PF00085 Thioredoxin 4 103 1.2E-33 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 ProSitePatterns PS00194 Thioredoxin family active site. 22 40 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 Gene3D G3DSA:3.40.30.10 3 105 1.1E-39 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 PRINTS PR00421 Thioredoxin family signature 29 38 3.0E-8 T 21-04-2016 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 PRINTS PR00421 Thioredoxin family signature 69 80 3.0E-8 T 21-04-2016 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 PRINTS PR00421 Thioredoxin family signature 21 29 3.0E-8 T 21-04-2016 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 PANTHER PTHR10438:SF290 5 102 1.1E-41 T 21-04-2016 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 TIGRFAM TIGR01068 thioredoxin: thioredoxin 6 103 2.6E-39 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS19470 3521d3c3124ecd06879058e20844b1cf 106 PANTHER PTHR10438 5 102 1.1E-41 T 21-04-2016 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SPH21_RS02950 62c4d1ad9c4a67847862c0c60fdc11e4 331 PANTHER PTHR22925 38 311 4.2E-61 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS02950 62c4d1ad9c4a67847862c0c60fdc11e4 331 PANTHER PTHR22925:SF42 38 311 4.2E-61 T 21-04-2016 SPH21_RS02950 62c4d1ad9c4a67847862c0c60fdc11e4 331 Gene3D G3DSA:2.115.10.20 33 314 8.2E-70 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02950 62c4d1ad9c4a67847862c0c60fdc11e4 331 SUPERFAMILY SSF75005 37 308 3.14E-62 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02950 62c4d1ad9c4a67847862c0c60fdc11e4 331 Pfam PF04616 Glycosyl hydrolases family 43 40 304 2.0E-50 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 ProSitePatterns PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature. 117 138 - T 21-04-2016 IPR020396 NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site GO:0016651|GO:0055114 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 PANTHER PTHR10884:SF6 28 152 1.3E-46 T 21-04-2016 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 SUPERFAMILY SSF143243 6 155 5.36E-43 T 21-04-2016 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 Pfam PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 32 154 1.4E-40 T 21-04-2016 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 PANTHER PTHR10884 28 152 1.3E-46 T 21-04-2016 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 Hamap MF_01357 NAD(P)H-quinone oxidoreductase subunit J, chloroplastic [ndhJ]. 6 164 26.737 T 21-04-2016 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 TIGRFAM TIGR01961 NuoC_fam: NADH (or F420H2) dehydrogenase, subunit C 32 153 1.6E-39 T 21-04-2016 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 SPH21_RS16640 9d2a798a16af8c050861f918286aeaa6 164 ProDom PD001581 OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE CHAIN C NAD DEHYDROGENASE UBIQUINONE F420H2 85 145 2.0E-13 T 21-04-2016 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 SPH21_RS13810 a813b7ed0b217a8e056ac0ddc002be00 334 Pfam PF00248 Aldo/keto reductase family 6 325 4.2E-34 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS13810 a813b7ed0b217a8e056ac0ddc002be00 334 PANTHER PTHR11732:SF236 2 313 2.5E-44 T 21-04-2016 SPH21_RS13810 a813b7ed0b217a8e056ac0ddc002be00 334 SUPERFAMILY SSF51430 3 326 4.98E-29 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS13810 a813b7ed0b217a8e056ac0ddc002be00 334 PANTHER PTHR11732 2 313 2.5E-44 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS13810 a813b7ed0b217a8e056ac0ddc002be00 334 Gene3D G3DSA:3.20.20.100 2 325 2.7E-24 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 Gene3D G3DSA:1.10.1060.10 28 137 2.6E-20 T 21-04-2016 SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 TIGRFAM TIGR01971 NuoI: NADH-quinone oxidoreductase, chain I 30 158 4.5E-39 T 21-04-2016 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 74 85 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 120 131 - T 21-04-2016 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 Pfam PF12838 4Fe-4S dicluster domain 73 134 8.4E-12 T 21-04-2016 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 PANTHER PTHR10849:SF13 20 161 1.2E-44 T 21-04-2016 SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 PANTHER PTHR10849 20 161 1.2E-44 T 21-04-2016 SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 SUPERFAMILY SSF54862 47 159 7.53E-25 T 21-04-2016 SPH21_RS07895 0ea361558065afc303064b7ce479b38f 169 Hamap MF_01351 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic [ndhI]. 21 162 27.332 T 21-04-2016 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 SPH21_RS21700 284e0770dd2ad1b627429c22f33bc3fc 122 Gene3D G3DSA:1.10.10.10 10 116 3.2E-35 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21700 284e0770dd2ad1b627429c22f33bc3fc 122 PANTHER PTHR33204 3 119 2.6E-29 T 21-04-2016 SPH21_RS21700 284e0770dd2ad1b627429c22f33bc3fc 122 SUPERFAMILY SSF46785 11 117 7.8E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21700 284e0770dd2ad1b627429c22f33bc3fc 122 Pfam PF01638 HxlR-like helix-turn-helix 24 110 6.7E-25 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 Pfam PF04542 Sigma-70 region 2 25 92 7.0E-14 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 Gene3D G3DSA:1.10.1740.10 7 111 1.1E-25 T 21-04-2016 SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 Pfam PF08281 Sigma-70, region 4 119 170 2.0E-17 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 SUPERFAMILY SSF88659 116 173 4.11E-16 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 PANTHER PTHR30173 1 174 5.0E-46 T 21-04-2016 SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 Gene3D G3DSA:1.10.10.10 116 174 4.3E-20 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 PANTHER PTHR30173:SF21 1 174 5.0E-46 T 21-04-2016 SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 21 174 1.2E-29 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS02060 2da74db6fbf1ecec73b69d49b853efb7 188 SUPERFAMILY SSF88946 7 106 4.32E-21 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 SUPERFAMILY SSF51735 3 246 1.94E-52 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PANTHER PTHR24322:SF323 7 133 3.3E-41 T 21-04-2016 SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PANTHER PTHR24322:SF323 149 181 3.3E-41 T 21-04-2016 SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 Gene3D G3DSA:3.40.50.720 3 246 1.2E-54 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 Pfam PF00106 short chain dehydrogenase 5 187 2.8E-42 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PANTHER PTHR24322 7 133 3.3E-41 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PANTHER PTHR24322 149 181 3.3E-41 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 2.5E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 2.5E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 2.5E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 170 187 2.5E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 168 2.5E-16 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 149 168 1.5E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 129 137 1.5E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21725 51361751de7091872e0b581d9e928d40 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 1.5E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS09640 71e565bd5586e8ca78035797cdd24eb2 359 Gene3D G3DSA:3.40.50.2000 175 355 2.6E-8 T 21-04-2016 SPH21_RS09640 71e565bd5586e8ca78035797cdd24eb2 359 Pfam PF13692 Glycosyl transferases group 1 196 326 2.0E-10 T 21-04-2016 SPH21_RS09640 71e565bd5586e8ca78035797cdd24eb2 359 SUPERFAMILY SSF53756 15 358 1.99E-24 T 21-04-2016 SPH21_RS11260 529865b170530aa8de8f3100250723fd 163 Gene3D G3DSA:1.20.120.450 12 91 3.9E-4 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS11260 529865b170530aa8de8f3100250723fd 163 SUPERFAMILY SSF109854 11 151 1.06E-11 T 21-04-2016 SPH21_RS11260 529865b170530aa8de8f3100250723fd 163 Pfam PF12867 DinB superfamily 11 144 7.4E-12 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS18315 9ea33ecf97c6cdd6a381fe24b9e5df97 294 PANTHER PTHR10314 9 292 6.2E-50 T 21-04-2016 SPH21_RS18315 9ea33ecf97c6cdd6a381fe24b9e5df97 294 PANTHER PTHR10314:SF79 9 292 6.2E-50 T 21-04-2016 SPH21_RS18315 9ea33ecf97c6cdd6a381fe24b9e5df97 294 SUPERFAMILY SSF53686 8 287 6.04E-64 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS18315 9ea33ecf97c6cdd6a381fe24b9e5df97 294 PIRSF PIRSF006278 3 294 5.1E-74 T 21-04-2016 IPR027278 1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase SPH21_RS18315 9ea33ecf97c6cdd6a381fe24b9e5df97 294 Gene3D G3DSA:3.40.50.1100 101 289 1.0E-52 T 21-04-2016 SPH21_RS18315 9ea33ecf97c6cdd6a381fe24b9e5df97 294 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 22 282 9.4E-30 T 21-04-2016 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SPH21_RS24215 9afcb3193a707e0f436a80cb3e56e633 102 Gene3D G3DSA:1.10.1660.10 56 97 6.5E-4 T 21-04-2016 SPH21_RS15905 dccbcd9717e0f371ece6bf1afd885cdf 233 PIRSF PIRSF000857 2 233 6.2E-75 T 21-04-2016 IPR004511 Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase GO:0004604|GO:0019379|GO:0055114 KEGG: 00920+1.8.4.8|UniPathway: UPA00140 SPH21_RS15905 dccbcd9717e0f371ece6bf1afd885cdf 233 Gene3D G3DSA:3.40.50.620 10 200 5.4E-51 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS15905 dccbcd9717e0f371ece6bf1afd885cdf 233 TIGRFAM TIGR00434 cysH: phosophoadenylyl-sulfate reductase 19 229 9.3E-51 T 21-04-2016 IPR004511 Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase GO:0004604|GO:0019379|GO:0055114 KEGG: 00920+1.8.4.8|UniPathway: UPA00140 SPH21_RS15905 dccbcd9717e0f371ece6bf1afd885cdf 233 TIGRFAM TIGR02055 APS_reductase: adenylylsulfate reductase, thioredoxin dependent 35 228 9.7E-73 T 21-04-2016 IPR011798 Adenosine 5'-phosphosulphate reductase GO:0004604|GO:0019344|GO:0055114 KEGG: 00920+1.8.4.8|UniPathway: UPA00140 SPH21_RS15905 dccbcd9717e0f371ece6bf1afd885cdf 233 SUPERFAMILY SSF52402 1 192 9.42E-44 T 21-04-2016 SPH21_RS15905 dccbcd9717e0f371ece6bf1afd885cdf 233 PANTHER PTHR23293 23 229 1.0E-63 T 21-04-2016 SPH21_RS15905 dccbcd9717e0f371ece6bf1afd885cdf 233 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family 29 204 7.9E-41 T 21-04-2016 IPR002500 Phosphoadenosine phosphosulphate reductase GO:0003824|GO:0008152 SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 Pfam PF00326 Prolyl oligopeptidase family 552 727 1.8E-49 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 PANTHER PTHR11731 171 749 1.2E-260 T 21-04-2016 SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 SUPERFAMILY SSF82171 169 481 4.58E-36 T 21-04-2016 SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 Gene3D G3DSA:2.140.10.30 35 483 4.8E-75 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 Pfam PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region 163 461 2.2E-51 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 SUPERFAMILY SSF53474 494 728 3.21E-55 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 PANTHER PTHR11731:SF118 171 749 1.2E-260 T 21-04-2016 SPH21_RS05000 00b803912db859a93383e4ab7cd22aac 749 Gene3D G3DSA:3.40.50.1820 494 741 1.1E-58 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS01675 9c6df8fb643ce4bfd3b96612f1097e47 294 Pfam PF11276 Protein of unknown function (DUF3078) 39 129 4.3E-31 T 21-04-2016 IPR021428 Protein of unknown function DUF3078 SPH21_RS07540 61abb3e05a34e8f7d8e6758d8a58addc 261 PANTHER PTHR10509 94 238 5.0E-17 T 21-04-2016 SPH21_RS07540 61abb3e05a34e8f7d8e6758d8a58addc 261 Gene3D G3DSA:3.40.50.150 92 244 2.0E-28 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS07540 61abb3e05a34e8f7d8e6758d8a58addc 261 SUPERFAMILY SSF53335 93 249 8.06E-26 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS07540 61abb3e05a34e8f7d8e6758d8a58addc 261 Pfam PF13578 Methyltransferase domain 111 215 3.5E-17 T 21-04-2016 SPH21_RS04685 43c25403674f2d71cf31ddfffd431a07 264 Gene3D G3DSA:1.10.10.60 202 251 2.6E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04685 43c25403674f2d71cf31ddfffd431a07 264 PANTHER PTHR11019:SF126 167 257 2.4E-19 T 21-04-2016 SPH21_RS04685 43c25403674f2d71cf31ddfffd431a07 264 Gene3D G3DSA:1.10.10.60 170 201 1.0E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04685 43c25403674f2d71cf31ddfffd431a07 264 PANTHER PTHR11019 167 257 2.4E-19 T 21-04-2016 SPH21_RS04685 43c25403674f2d71cf31ddfffd431a07 264 SUPERFAMILY SSF46689 201 252 2.37E-8 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04685 43c25403674f2d71cf31ddfffd431a07 264 SMART SM00342 169 249 1.6E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04685 43c25403674f2d71cf31ddfffd431a07 264 Pfam PF12833 Helix-turn-helix domain 173 250 3.7E-21 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22175 67e3fe81866bee3d7d0027c14a71a4ba 212 PANTHER PTHR38474:SF1 14 211 2.9E-55 T 21-04-2016 SPH21_RS22175 67e3fe81866bee3d7d0027c14a71a4ba 212 Gene3D G3DSA:3.30.559.10 5 210 2.8E-64 T 21-04-2016 IPR023213 Chloramphenicol acetyltransferase-like domain SPH21_RS22175 67e3fe81866bee3d7d0027c14a71a4ba 212 ProDom PD002660 TRANSFERASE CHLORAMPHENICOL ACYLTRANSFERASE ACETYLTRANSFERASE ANTIBIOTIC RESISTANCE PLASMID CAT O-ACETYLTRANSFERASE DIRECT 14 203 6.0E-36 T 21-04-2016 IPR001707 Chloramphenicol acetyltransferase GO:0008811 SPH21_RS22175 67e3fe81866bee3d7d0027c14a71a4ba 212 Pfam PF00302 Chloramphenicol acetyltransferase 6 207 1.2E-31 T 21-04-2016 IPR001707 Chloramphenicol acetyltransferase GO:0008811 SPH21_RS22175 67e3fe81866bee3d7d0027c14a71a4ba 212 SMART SM01059 5 207 9.8E-65 T 21-04-2016 IPR001707 Chloramphenicol acetyltransferase GO:0008811 SPH21_RS22175 67e3fe81866bee3d7d0027c14a71a4ba 212 PANTHER PTHR38474 14 211 2.9E-55 T 21-04-2016 SPH21_RS22175 67e3fe81866bee3d7d0027c14a71a4ba 212 SUPERFAMILY SSF52777 7 211 7.94E-49 T 21-04-2016 SPH21_RS04045 3b9a62e8979408e24942aa8522c3cc54 189 Gene3D G3DSA:1.20.1290.10 56 173 2.3E-19 T 21-04-2016 IPR029032 AhpD-like SPH21_RS04045 3b9a62e8979408e24942aa8522c3cc54 189 Pfam PF02627 Carboxymuconolactone decarboxylase family 49 101 2.9E-12 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS04045 3b9a62e8979408e24942aa8522c3cc54 189 SUPERFAMILY SSF69118 1 173 1.1E-32 T 21-04-2016 IPR029032 AhpD-like SPH21_RS04045 3b9a62e8979408e24942aa8522c3cc54 189 PANTHER PTHR35446:SF1 1 187 1.1E-19 T 21-04-2016 SPH21_RS04045 3b9a62e8979408e24942aa8522c3cc54 189 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 56 99 1.8E-8 T 21-04-2016 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS04045 3b9a62e8979408e24942aa8522c3cc54 189 Gene3D G3DSA:1.20.5.810 12 51 1.8E-4 T 21-04-2016 SPH21_RS04045 3b9a62e8979408e24942aa8522c3cc54 189 PANTHER PTHR35446 1 187 1.1E-19 T 21-04-2016 SPH21_RS18780 e5d422b3e1625588d232d811ba7460b2 261 Pfam PF14080 Domain of unknown function (DUF4261) 186 259 2.4E-20 T 21-04-2016 IPR025357 Domain of unknown function DUF4261 SPH21_RS07730 3c7157b8ebb12e27bfa5875fceee2e1e 174 Pfam PF04238 Protein of unknown function (DUF420) 41 169 2.7E-46 T 21-04-2016 IPR007352 Protein of unknown function DUF420 SPH21_RS07730 3c7157b8ebb12e27bfa5875fceee2e1e 174 PANTHER PTHR37692 1 174 2.0E-39 T 21-04-2016 SPH21_RS14020 b9fdc3fe036f9dc2ccbf5180768ea5da 472 PIRSF PIRSF028846 39 472 4.1E-188 T 21-04-2016 IPR008313 Meiotically up-regulated gene 157 protein SPH21_RS14020 b9fdc3fe036f9dc2ccbf5180768ea5da 472 SMART SM01149 61 462 2.9E-258 T 21-04-2016 IPR008313 Meiotically up-regulated gene 157 protein SPH21_RS14020 b9fdc3fe036f9dc2ccbf5180768ea5da 472 SUPERFAMILY SSF48208 39 467 4.33E-179 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS14020 b9fdc3fe036f9dc2ccbf5180768ea5da 472 Gene3D G3DSA:1.50.10.10 45 471 1.2E-182 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS14020 b9fdc3fe036f9dc2ccbf5180768ea5da 472 PANTHER PTHR31047:SF0 30 471 2.9E-218 T 21-04-2016 SPH21_RS14020 b9fdc3fe036f9dc2ccbf5180768ea5da 472 Pfam PF06824 Protein of unknown function (DUF1237) 62 460 9.3E-165 T 21-04-2016 IPR008313 Meiotically up-regulated gene 157 protein SPH21_RS14020 b9fdc3fe036f9dc2ccbf5180768ea5da 472 PANTHER PTHR31047 30 471 2.9E-218 T 21-04-2016 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 SMART SM00028 72 105 12.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 SMART SM00028 453 486 27.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 SMART SM00028 496 529 24.0 T 21-04-2016 IPR019734 Tetratricopeptide repeat GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 SUPERFAMILY SSF48452 228 309 5.26E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 SUPERFAMILY SSF48452 476 530 5.26E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 SUPERFAMILY SSF48452 70 128 5.26E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 Gene3D G3DSA:1.25.40.10 180 289 1.7E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 Gene3D G3DSA:1.25.40.10 402 546 1.7E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 Gene3D G3DSA:1.25.40.10 324 349 1.7E-16 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 SUPERFAMILY SSF48452 399 549 1.98E-9 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23755 895cb0c8a03433dac57400154d75a95e 572 Gene3D G3DSA:1.25.40.10 66 137 3.2E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12840 d063eeabb331d32b3b6f6768f8d20dde 211 PANTHER PTHR24220 25 198 1.2E-62 T 21-04-2016 SPH21_RS12840 d063eeabb331d32b3b6f6768f8d20dde 211 Gene3D G3DSA:3.40.50.300 3 202 3.1E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12840 d063eeabb331d32b3b6f6768f8d20dde 211 SUPERFAMILY SSF52540 4 206 2.66E-51 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12840 d063eeabb331d32b3b6f6768f8d20dde 211 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS12840 d063eeabb331d32b3b6f6768f8d20dde 211 Pfam PF00005 ABC transporter 25 167 9.0E-31 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS12840 d063eeabb331d32b3b6f6768f8d20dde 211 SMART SM00382 29 207 3.1E-13 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS09550 0a0eeb739f1635bee93108989f71c4c6 421 PANTHER PTHR35148 12 421 1.8E-41 T 21-04-2016 SPH21_RS09550 0a0eeb739f1635bee93108989f71c4c6 421 SUPERFAMILY SSF48452 6 420 1.24E-99 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09550 0a0eeb739f1635bee93108989f71c4c6 421 Pfam PF12771 Starch-binding associating with outer membrane 30 420 1.6E-50 T 21-04-2016 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 Gene3D G3DSA:3.40.50.2300 4 154 1.1E-38 T 21-04-2016 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 193 8.3E-13 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 165 8.3E-13 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 181 8.3E-13 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 Gene3D G3DSA:1.10.10.10 155 211 1.5E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 PANTHER PTHR26402 6 205 2.0E-64 T 21-04-2016 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 SMART SM00448 6 119 2.1E-27 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 Pfam PF00072 Response regulator receiver domain 9 120 5.3E-29 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 SUPERFAMILY SSF46894 136 211 5.78E-21 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 ProSitePatterns PS00622 LuxR-type HTH domain signature. 165 192 - T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 SUPERFAMILY SSF52172 6 136 3.84E-34 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 SMART SM00421 148 205 1.1E-22 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS03545 eaa539c3b6d63bd0d6dcf836c41cff84 211 Pfam PF00196 Bacterial regulatory proteins, luxR family 151 205 2.6E-21 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 ProSitePatterns PS00216 Sugar transport proteins signature 1. 62 79 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 Gene3D G3DSA:1.20.1250.20 9 188 8.9E-33 T 21-04-2016 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 Gene3D G3DSA:1.20.1250.20 269 456 1.0E-17 T 21-04-2016 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 Pfam PF07690 Major Facilitator Superfamily 13 407 7.7E-51 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 PANTHER PTHR23501 7 462 1.3E-89 T 21-04-2016 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 SUPERFAMILY SSF103473 244 450 4.19E-64 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 SUPERFAMILY SSF103473 6 191 4.19E-64 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 PRINTS PR01036 Tetracycline resistance protein TetB signature 133 157 4.2E-8 T 21-04-2016 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 PRINTS PR01036 Tetracycline resistance protein TetB signature 11 35 4.2E-8 T 21-04-2016 SPH21_RS13870 1dd57b3dd1929500dd25a9ae0f677b84 463 PRINTS PR01036 Tetracycline resistance protein TetB signature 398 417 4.2E-8 T 21-04-2016 SPH21_RS12535 56f1eab3e7444659a7668a66a3c43dd2 262 Pfam PF01887 S-adenosyl-l-methionine hydroxide adenosyltransferase 4 253 2.0E-72 T 21-04-2016 IPR002747 SAM-dependent chlorinase/fluorinase SPH21_RS12535 56f1eab3e7444659a7668a66a3c43dd2 262 PANTHER PTHR35092 1 262 3.9E-58 T 21-04-2016 SPH21_RS12535 56f1eab3e7444659a7668a66a3c43dd2 262 SUPERFAMILY SSF101852 158 256 1.14E-19 T 21-04-2016 IPR023227 S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal SPH21_RS12535 56f1eab3e7444659a7668a66a3c43dd2 262 PIRSF PIRSF006779 1 258 1.3E-63 T 21-04-2016 IPR002747 SAM-dependent chlorinase/fluorinase SPH21_RS12535 56f1eab3e7444659a7668a66a3c43dd2 262 SUPERFAMILY SSF102522 1 150 2.88E-38 T 21-04-2016 IPR023228 S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal SPH21_RS12535 56f1eab3e7444659a7668a66a3c43dd2 262 Gene3D G3DSA:2.40.30.90 158 257 3.9E-29 T 21-04-2016 IPR023227 S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal SPH21_RS08350 2d2bde9d9537cd5964da51922cf33899 221 PANTHER PTHR39200:SF1 15 221 3.5E-29 T 21-04-2016 SPH21_RS08350 2d2bde9d9537cd5964da51922cf33899 221 Pfam PF10988 Putative auto-transporter adhesin, head GIN domain 22 204 1.4E-48 T 21-04-2016 IPR021255 Putative auto-transporter adhesin, head GIN domain SPH21_RS08350 2d2bde9d9537cd5964da51922cf33899 221 PANTHER PTHR39200 15 221 3.5E-29 T 21-04-2016 SPH21_RS14430 7b2b3b6b580a1b8358b5de41c7ce7590 316 SUPERFAMILY SSF56784 55 251 8.69E-18 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS14430 7b2b3b6b580a1b8358b5de41c7ce7590 316 Gene3D G3DSA:3.40.50.1000 131 258 5.8E-15 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS14430 7b2b3b6b580a1b8358b5de41c7ce7590 316 Pfam PF12710 haloacid dehalogenase-like hydrolase 58 243 4.5E-17 T 21-04-2016 SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 PANTHER PTHR13932 10 442 1.5E-159 T 21-04-2016 SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 TIGRFAM TIGR00538 hemN: oxygen-independent coproporphyrinogen III oxidase 9 448 2.9E-120 T 21-04-2016 IPR004558 Coproporphyrinogen III oxidase, oxygen-independent, HemN GO:0004109|GO:0005737|GO:0006779|GO:0055114 KEGG: 00860+1.3.99.22|UniPathway: UPA00251 SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 SUPERFAMILY SSF102114 7 434 2.49E-115 T 21-04-2016 SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 Pfam PF04055 Radical SAM superfamily 56 225 2.3E-16 T 21-04-2016 IPR007197 Radical SAM GO:0003824|GO:0051536 SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 PANTHER PTHR13932:SF6 10 442 1.5E-159 T 21-04-2016 SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 PIRSF PIRSF000167 1 445 2.6E-142 T 21-04-2016 IPR004558 Coproporphyrinogen III oxidase, oxygen-independent, HemN GO:0004109|GO:0005737|GO:0006779|GO:0055114 KEGG: 00860+1.3.99.22|UniPathway: UPA00251 SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 Gene3D G3DSA:3.80.30.20 52 270 3.3E-28 T 21-04-2016 IPR023404 Radical SAM, alpha/beta horseshoe SPH21_RS17535 a0d92f5933a14c9037d892925cc0cdcd 449 SMART SM00729 51 269 4.7E-42 T 21-04-2016 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 SUPERFAMILY SSF52279 462 570 3.14E-5 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 Gene3D G3DSA:3.20.20.300 53 388 2.1E-91 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 50 364 1.3E-78 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 SUPERFAMILY SSF51445 34 400 9.58E-86 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 286 303 - T 21-04-2016 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 PANTHER PTHR30480:SF5 32 562 1.2E-113 T 21-04-2016 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 Gene3D G3DSA:3.40.50.1700 459 561 8.5E-6 T 21-04-2016 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 PANTHER PTHR30480 32 562 1.2E-113 T 21-04-2016 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 PRINTS PR00133 Glycosyl hydrolase family 3 signature 208 224 7.8E-7 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 PRINTS PR00133 Glycosyl hydrolase family 3 signature 130 149 7.8E-7 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 PRINTS PR00133 Glycosyl hydrolase family 3 signature 104 120 7.8E-7 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS03875 763e8756bbd20882b60b2ab023442d95 570 PRINTS PR00133 Glycosyl hydrolase family 3 signature 286 304 7.8E-7 T 21-04-2016 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SPH21_RS01480 eedebe53ffa7d448dfa8a0c682fb2757 357 Pfam PF13495 Phage integrase, N-terminal SAM-like domain 85 164 3.4E-12 T 21-04-2016 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SPH21_RS01480 eedebe53ffa7d448dfa8a0c682fb2757 357 SUPERFAMILY SSF56349 90 341 1.08E-55 T 21-04-2016 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SPH21_RS01480 eedebe53ffa7d448dfa8a0c682fb2757 357 Pfam PF00589 Phage integrase family 182 341 1.9E-41 T 21-04-2016 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS01480 eedebe53ffa7d448dfa8a0c682fb2757 357 Gene3D G3DSA:1.10.443.10 182 347 5.5E-48 T 21-04-2016 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS01480 eedebe53ffa7d448dfa8a0c682fb2757 357 PANTHER PTHR30349 15 355 1.9E-65 T 21-04-2016 SPH21_RS01480 eedebe53ffa7d448dfa8a0c682fb2757 357 PANTHER PTHR30349:SF5 15 355 1.9E-65 T 21-04-2016 SPH21_RS18455 d2bb51e0f223a9ec06131dcf0891b09a 179 SUPERFAMILY SSF53335 30 151 1.04E-32 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18455 d2bb51e0f223a9ec06131dcf0891b09a 179 Gene3D G3DSA:3.40.50.150 35 161 1.9E-24 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18455 d2bb51e0f223a9ec06131dcf0891b09a 179 PANTHER PTHR13610 3 178 1.2E-57 T 21-04-2016 IPR026170 FAM173 family SPH21_RS18455 d2bb51e0f223a9ec06131dcf0891b09a 179 Pfam PF13847 Methyltransferase domain 55 118 1.1E-13 T 21-04-2016 IPR025714 Methyltransferase domain SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 SUPERFAMILY SSF103473 410 519 1.44E-7 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 Gene3D G3DSA:1.20.1250.20 411 518 5.0E-16 T 21-04-2016 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 Gene3D G3DSA:1.20.1250.20 17 223 1.2E-24 T 21-04-2016 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 Gene3D G3DSA:1.20.1250.20 246 334 5.0E-16 T 21-04-2016 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 SUPERFAMILY SSF103473 16 325 3.4E-54 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 PANTHER PTHR23508:SF7 413 523 1.5E-196 T 21-04-2016 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 PANTHER PTHR23508:SF7 17 337 1.5E-196 T 21-04-2016 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 Pfam PF00083 Sugar (and other) transporter 23 324 5.5E-26 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 PANTHER PTHR23508 413 523 1.5E-196 T 21-04-2016 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 PANTHER PTHR23508 17 337 1.5E-196 T 21-04-2016 SPH21_RS25505 90da2a24656f9ee860801d985cbb5964 525 ProSitePatterns PS00217 Sugar transport proteins signature 2. 128 153 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS16965 f7e18205d34e84301e1a679c866436ea 215 Gene3D G3DSA:3.40.50.150 1 165 6.6E-21 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS16965 f7e18205d34e84301e1a679c866436ea 215 Pfam PF13649 Methyltransferase domain 41 137 1.2E-13 T 21-04-2016 SPH21_RS16965 f7e18205d34e84301e1a679c866436ea 215 SUPERFAMILY SSF53335 2 173 1.54E-25 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS16965 f7e18205d34e84301e1a679c866436ea 215 PANTHER PTHR10108 5 149 3.4E-13 T 21-04-2016 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 Pfam PF01432 Peptidase family M3 226 671 8.2E-135 T 21-04-2016 IPR001567 Peptidase M3A/M3B GO:0004222|GO:0006508 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 PANTHER PTHR11804:SF47 3 673 4.1E-241 T 21-04-2016 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 Gene3D G3DSA:3.40.390.10 357 500 2.7E-52 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 PANTHER PTHR11804 3 673 4.1E-241 T 21-04-2016 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 SUPERFAMILY SSF55486 1 671 1.02E-184 T 21-04-2016 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 Gene3D G3DSA:1.10.1370.10 144 348 7.4E-123 T 21-04-2016 IPR024077 Neurolysin/Thimet oligopeptidase, domain 2 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 Gene3D G3DSA:1.10.1370.10 501 672 7.4E-123 T 21-04-2016 IPR024077 Neurolysin/Thimet oligopeptidase, domain 2 SPH21_RS20015 52800359b716c067db39fd435618f5d9 675 Gene3D G3DSA:1.20.1050.40 11 143 3.5E-26 T 21-04-2016 IPR024080 Neurolysin/Thimet oligopeptidase, N-terminal SPH21_RS04680 41f255f1c950edc37080a518c92d6cfc 283 TIGRFAM TIGR00027 mthyl_TIGR00027: methyltransferase, TIGR00027 family 10 264 2.3E-47 T 21-04-2016 IPR011610 S-adenosyl-L-methionine-dependent methyltransferase, putative GO:0008168 KEGG: 00253+2.1.1.-|KEGG: 00270+2.1.1.-|KEGG: 00332+2.1.1.-|KEGG: 00340+2.1.1.-|KEGG: 00350+2.1.1.-|KEGG: 00360+2.1.1.-|KEGG: 00380+2.1.1.-|KEGG: 00450+2.1.1.-|KEGG: 00522+2.1.1.-|KEGG: 00523+2.1.1.-|KEGG: 00624+2.1.1.-|KEGG: 00627+2.1.1.-|KEGG: 00860+2.1.1.-|KEGG: 00940+2.1.1.-|KEGG: 00941+2.1.1.-|KEGG: 00942+2.1.1.-|KEGG: 00945+2.1.1.-|KEGG: 00950+2.1.1.-|KEGG: 00981+2.1.1.- SPH21_RS04680 41f255f1c950edc37080a518c92d6cfc 283 Gene3D G3DSA:3.40.50.150 64 260 2.0E-15 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS04680 41f255f1c950edc37080a518c92d6cfc 283 Pfam PF04072 Leucine carboxyl methyltransferase 12 188 9.0E-48 T 21-04-2016 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 KEGG: 00253+2.1.1.-|KEGG: 00270+2.1.1.-|KEGG: 00332+2.1.1.-|KEGG: 00340+2.1.1.-|KEGG: 00350+2.1.1.-|KEGG: 00360+2.1.1.-|KEGG: 00380+2.1.1.-|KEGG: 00450+2.1.1.-|KEGG: 00522+2.1.1.-|KEGG: 00523+2.1.1.-|KEGG: 00624+2.1.1.-|KEGG: 00627+2.1.1.-|KEGG: 00860+2.1.1.-|KEGG: 00940+2.1.1.-|KEGG: 00941+2.1.1.-|KEGG: 00942+2.1.1.-|KEGG: 00945+2.1.1.-|KEGG: 00950+2.1.1.-|KEGG: 00981+2.1.1.- SPH21_RS04680 41f255f1c950edc37080a518c92d6cfc 283 PANTHER PTHR13600 11 270 2.5E-43 T 21-04-2016 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 KEGG: 00253+2.1.1.-|KEGG: 00270+2.1.1.-|KEGG: 00332+2.1.1.-|KEGG: 00340+2.1.1.-|KEGG: 00350+2.1.1.-|KEGG: 00360+2.1.1.-|KEGG: 00380+2.1.1.-|KEGG: 00450+2.1.1.-|KEGG: 00522+2.1.1.-|KEGG: 00523+2.1.1.-|KEGG: 00624+2.1.1.-|KEGG: 00627+2.1.1.-|KEGG: 00860+2.1.1.-|KEGG: 00940+2.1.1.-|KEGG: 00941+2.1.1.-|KEGG: 00942+2.1.1.-|KEGG: 00945+2.1.1.-|KEGG: 00950+2.1.1.-|KEGG: 00981+2.1.1.- SPH21_RS04680 41f255f1c950edc37080a518c92d6cfc 283 SUPERFAMILY SSF53335 9 281 1.34E-60 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS04680 41f255f1c950edc37080a518c92d6cfc 283 PANTHER PTHR13600:SF12 11 270 2.5E-43 T 21-04-2016 SPH21_RS02590 054d81d30cdea5ba684b1c3075fe04fb 177 SMART SM00867 3 174 1.0E-43 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS02590 054d81d30cdea5ba684b1c3075fe04fb 177 PANTHER PTHR34406:SF1 4 177 2.6E-40 T 21-04-2016 SPH21_RS02590 054d81d30cdea5ba684b1c3075fe04fb 177 Gene3D G3DSA:2.40.128.110 3 175 1.4E-48 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS02590 054d81d30cdea5ba684b1c3075fe04fb 177 SUPERFAMILY SSF101874 3 175 3.01E-43 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS02590 054d81d30cdea5ba684b1c3075fe04fb 177 PANTHER PTHR34406 4 177 2.6E-40 T 21-04-2016 SPH21_RS02590 054d81d30cdea5ba684b1c3075fe04fb 177 Pfam PF04264 YceI-like domain 4 172 5.5E-39 T 21-04-2016 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SPH21_RS03520 8068444d1201dda66554069131137849 449 PANTHER PTHR33608:SF3 5 449 2.7E-110 T 21-04-2016 SPH21_RS03520 8068444d1201dda66554069131137849 449 Pfam PF01882 Protein of unknown function DUF58 205 289 9.8E-18 T 21-04-2016 IPR002881 Domain of unknown function DUF58 SPH21_RS03520 8068444d1201dda66554069131137849 449 PANTHER PTHR33608 5 449 2.7E-110 T 21-04-2016 SPH21_RS03520 8068444d1201dda66554069131137849 449 SUPERFAMILY SSF53300 240 353 5.17E-7 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 SUPERFAMILY SSF46785 96 176 3.01E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 Gene3D G3DSA:1.10.10.10 98 176 5.7E-27 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 PANTHER PTHR38768 1 220 1.7E-58 T 21-04-2016 SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 SUPERFAMILY SSF46785 7 88 2.55E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 Gene3D G3DSA:1.10.10.10 3 91 3.0E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 PANTHER PTHR38768:SF1 1 220 1.7E-58 T 21-04-2016 SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 Hamap MF_01584 UPF0502 protein YceH [yceH]. 10 217 28.629 T 21-04-2016 IPR007432 Protein of unknown function DUF480 SPH21_RS10840 18f6e480b297c5845a3aa98be04b57c6 220 Pfam PF04337 Protein of unknown function, DUF480 10 160 5.0E-55 T 21-04-2016 IPR007432 Protein of unknown function DUF480 SPH21_RS17940 969534054ea3494bf7fc60f110c63fea 148 Pfam PF11412 Disulphide bond corrector protein DsbC 35 144 9.0E-18 T 21-04-2016 IPR028250 Thiol:disulfide interchange protein DsbD, N-terminal domain SPH21_RS17940 969534054ea3494bf7fc60f110c63fea 148 Gene3D G3DSA:2.60.40.1250 35 145 1.8E-7 T 21-04-2016 IPR028250 Thiol:disulfide interchange protein DsbD, N-terminal domain SPH21_RS13700 f85f6e55d26595b08c6a3cf8098c5516 571 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 58 128 2.1E-5 T 21-04-2016 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SPH21_RS13700 f85f6e55d26595b08c6a3cf8098c5516 571 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 162 267 1.4E-8 T 21-04-2016 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SPH21_RS13700 f85f6e55d26595b08c6a3cf8098c5516 571 SUPERFAMILY SSF49899 282 471 1.62E-17 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS13700 f85f6e55d26595b08c6a3cf8098c5516 571 Gene3D G3DSA:3.40.720.10 55 251 1.5E-19 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS13700 f85f6e55d26595b08c6a3cf8098c5516 571 SUPERFAMILY SSF53649 55 251 6.38E-20 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS13700 f85f6e55d26595b08c6a3cf8098c5516 571 Gene3D G3DSA:2.60.120.200 290 466 4.7E-13 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS13700 f85f6e55d26595b08c6a3cf8098c5516 571 Pfam PF16356 Domain of unknown function (DUF4983) 477 569 1.0E-43 T 21-04-2016 IPR032309 Domain of unknown function DUF4983 SPH21_RS05070 de7ae1cc6e1970fc893f1b9866a2eb44 565 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 40 467 4.1E-87 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS05070 de7ae1cc6e1970fc893f1b9866a2eb44 565 Pfam PF00474 Sodium:solute symporter family 40 467 2.7E-58 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS05070 de7ae1cc6e1970fc893f1b9866a2eb44 565 PANTHER PTHR11819:SF7 5 523 2.0E-128 T 21-04-2016 SPH21_RS05070 de7ae1cc6e1970fc893f1b9866a2eb44 565 PANTHER PTHR11819 5 523 2.0E-128 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS24840 e2a0a8603de3e678b928b6bf9712975a 148 Gene3D G3DSA:1.20.120.450 28 147 1.9E-11 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS24840 e2a0a8603de3e678b928b6bf9712975a 148 SUPERFAMILY SSF109854 37 147 1.13E-15 T 21-04-2016 SPH21_RS24840 e2a0a8603de3e678b928b6bf9712975a 148 Pfam PF07609 Protein of unknown function (DUF1572) 24 146 1.2E-6 T 21-04-2016 IPR011466 Protein of unknown function DUF1572 SPH21_RS05365 c87f5f4312015f3baa0f9e8b0c363d9c 934 Pfam PF14028 Lantibiotic biosynthesis dehydratase C-term 673 918 4.7E-30 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS05365 c87f5f4312015f3baa0f9e8b0c363d9c 934 TIGRFAM TIGR03891 thiopep_ocin: thiopeptide-type bacteriocin biosynthesis domain 673 918 2.4E-48 T 21-04-2016 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SPH21_RS05365 c87f5f4312015f3baa0f9e8b0c363d9c 934 Pfam PF04738 Lantibiotic dehydratase, C terminus 28 225 4.2E-27 T 21-04-2016 IPR006827 Lantibiotic dehydratase, C-terminal SPH21_RS05365 c87f5f4312015f3baa0f9e8b0c363d9c 934 Pfam PF04738 Lantibiotic dehydratase, C terminus 265 604 1.3E-50 T 21-04-2016 IPR006827 Lantibiotic dehydratase, C-terminal SPH21_RS05365 c87f5f4312015f3baa0f9e8b0c363d9c 934 Gene3D G3DSA:1.10.490.10 799 882 7.3E-4 T 21-04-2016 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 SPH21_RS08245 195f78736643c21112466341b5b37594 297 PANTHER PTHR11061 1 245 7.2E-67 T 21-04-2016 SPH21_RS08245 195f78736643c21112466341b5b37594 297 Pfam PF10672 S-adenosylmethionine-dependent methyltransferase 80 214 3.7E-10 T 21-04-2016 IPR019614 S-adenosylmethionine-dependent methyltransferase GO:0008168 SPH21_RS08245 195f78736643c21112466341b5b37594 297 PANTHER PTHR11061:SF33 1 245 7.2E-67 T 21-04-2016 SPH21_RS08245 195f78736643c21112466341b5b37594 297 Gene3D G3DSA:3.40.50.150 28 274 4.3E-67 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS08245 195f78736643c21112466341b5b37594 297 SUPERFAMILY SSF53335 9 268 5.31E-47 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS07330 13b8134cd63716056f977fb152bb88a7 360 SUPERFAMILY SSF111369 46 265 7.85E-50 T 21-04-2016 SPH21_RS07330 13b8134cd63716056f977fb152bb88a7 360 PANTHER PTHR30158 25 355 1.4E-114 T 21-04-2016 SPH21_RS07330 13b8134cd63716056f977fb152bb88a7 360 Gene3D G3DSA:2.40.50.100 58 90 2.7E-18 T 21-04-2016 SPH21_RS07330 13b8134cd63716056f977fb152bb88a7 360 Gene3D G3DSA:2.40.50.100 151 183 2.7E-18 T 21-04-2016 SPH21_RS07330 13b8134cd63716056f977fb152bb88a7 360 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 56 260 4.3E-22 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS07330 13b8134cd63716056f977fb152bb88a7 360 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 46 342 5.3E-68 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS07330 13b8134cd63716056f977fb152bb88a7 360 PANTHER PTHR30158:SF6 25 355 1.4E-114 T 21-04-2016 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PANTHER PTHR11739 18 428 2.0E-190 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PIRSF PIRSF001369 36 428 9.1E-156 T 21-04-2016 IPR024176 Citrate synthase, bacterial-type UniPathway: UPA00223 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 Pfam PF00285 Citrate synthase, C-terminal domain 45 411 3.8E-132 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 ProSitePatterns PS00480 Citrate synthase signature. 304 316 - T 21-04-2016 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 UniPathway: UPA00223 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 Gene3D G3DSA:1.10.580.10 51 280 4.9E-91 T 21-04-2016 IPR016142 Citrate synthase-like, large alpha subdomain UniPathway: UPA00223 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 SUPERFAMILY SSF48256 3 428 4.32E-155 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 Gene3D G3DSA:1.10.230.10 281 374 8.5E-39 T 21-04-2016 IPR016143 Citrate synthase-like, small alpha subdomain SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 TIGRFAM TIGR01798 cit_synth_I: citrate (Si)-synthase 11 422 1.8E-176 T 21-04-2016 IPR010953 Citrate synthase, type I GO:0004108|GO:0005737 UniPathway: UPA00223 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PRINTS PR00143 Citrate synthase signature 219 234 3.3E-53 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PRINTS PR00143 Citrate synthase signature 241 269 3.3E-53 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PRINTS PR00143 Citrate synthase signature 380 394 3.3E-53 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PRINTS PR00143 Citrate synthase signature 360 376 3.3E-53 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PRINTS PR00143 Citrate synthase signature 297 317 3.3E-53 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS18050 555d1b6b963cfc60dbc0063d5b6f890c 428 PRINTS PR00143 Citrate synthase signature 165 178 3.3E-53 T 21-04-2016 IPR002020 Citrate synthase GO:0046912 SPH21_RS14480 0a4b4d04bfe001e4c6d52e3a8f6c7b74 81 Gene3D G3DSA:3.40.30.10 3 77 2.7E-13 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS14480 0a4b4d04bfe001e4c6d52e3a8f6c7b74 81 Pfam PF00085 Thioredoxin 4 73 3.7E-7 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS14480 0a4b4d04bfe001e4c6d52e3a8f6c7b74 81 SUPERFAMILY SSF52833 4 73 1.65E-15 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS04580 9ff12b369112465ebd6250c71dd12f30 387 SUPERFAMILY SSF48208 8 384 1.02E-96 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS04580 9ff12b369112465ebd6250c71dd12f30 387 Hamap MF_00929 Cellobiose 2-epimerase. 3 384 44.305 T 21-04-2016 IPR028584 Cellobiose 2-epimerase GO:0047736 MetaCyc: PWY-7456 SPH21_RS04580 9ff12b369112465ebd6250c71dd12f30 387 Pfam PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) 26 368 5.5E-46 T 21-04-2016 SPH21_RS04580 9ff12b369112465ebd6250c71dd12f30 387 Gene3D G3DSA:1.50.10.10 4 383 3.6E-123 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS04580 9ff12b369112465ebd6250c71dd12f30 387 PANTHER PTHR15108 5 382 2.8E-61 T 21-04-2016 SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 SUPERFAMILY SSF51735 28 190 6.16E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 PANTHER PTHR22604 1 400 8.9E-66 T 21-04-2016 SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 35 158 4.2E-18 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 Gene3D G3DSA:3.30.360.10 171 395 7.1E-33 T 21-04-2016 SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 Gene3D G3DSA:3.40.50.720 32 170 1.0E-39 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 170 262 3.2E-8 T 21-04-2016 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 SUPERFAMILY SSF55347 163 348 1.46E-26 T 21-04-2016 SPH21_RS19795 67df422ecb34e5b3f91b0e438be6a908 400 PANTHER PTHR22604:SF101 1 400 8.9E-66 T 21-04-2016 SPH21_RS20925 0d95fadb5b3a6828b54853c5c57fb25b 258 Pfam PF02517 CAAX protease self-immunity 108 202 1.7E-15 T 21-04-2016 IPR003675 CAAX amino terminal protease GO:0016020 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 Gene3D G3DSA:3.40.50.10320 356 396 2.8E-53 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 Gene3D G3DSA:3.40.50.10320 438 638 2.8E-53 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 Pfam PF02585 GlcNAc-PI de-N-acetylase 361 536 4.2E-16 T 21-04-2016 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 Pfam PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 23 244 3.0E-18 T 21-04-2016 IPR006148 Glucosamine/galactosamine-6-phosphate isomerase GO:0005975 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 SUPERFAMILY SSF100950 16 276 7.85E-88 T 21-04-2016 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 SUPERFAMILY SSF102588 357 396 6.28E-37 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 SUPERFAMILY SSF102588 441 630 6.28E-37 T 21-04-2016 IPR024078 Putative deacetylase LmbE-like domain SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 PANTHER PTHR11280:SF7 359 639 0.0 T 21-04-2016 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 PANTHER PTHR11280:SF7 1 334 0.0 T 21-04-2016 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 Gene3D G3DSA:3.40.50.1360 16 278 1.8E-95 T 21-04-2016 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 PANTHER PTHR11280 359 639 0.0 T 21-04-2016 IPR004547 Glucosamine-6-phosphate isomerase GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|UniPathway: UPA00629 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 PANTHER PTHR11280 1 334 0.0 T 21-04-2016 IPR004547 Glucosamine-6-phosphate isomerase GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|UniPathway: UPA00629 SPH21_RS07445 1b2d1602c2848fdfc36aad19f17a506d 639 TIGRFAM TIGR00502 nagB: glucosamine-6-phosphate deaminase 27 262 1.0E-73 T 21-04-2016 IPR004547 Glucosamine-6-phosphate isomerase GO:0004342|GO:0006044 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906|UniPathway: UPA00629 SPH21_RS11590 2927f514730d3e34576cb4845d200146 780 SUPERFAMILY SSF48208 301 764 6.63E-36 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS26150 38ba6f748ab308b5acd1ee49969328d4 327 PIRSF PIRSF018266 3 327 1.1E-36 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26150 38ba6f748ab308b5acd1ee49969328d4 327 Pfam PF16344 Domain of unknown function (DUF4974) 213 317 2.0E-7 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS26150 38ba6f748ab308b5acd1ee49969328d4 327 Pfam PF04773 FecR protein 117 199 3.8E-13 T 21-04-2016 IPR006860 FecR protein SPH21_RS26150 38ba6f748ab308b5acd1ee49969328d4 327 PANTHER PTHR30273 17 316 1.6E-26 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26150 38ba6f748ab308b5acd1ee49969328d4 327 PANTHER PTHR30273:SF2 17 316 1.6E-26 T 21-04-2016 SPH21_RS23400 7f360f52c92ac297ffcb16b061d0d51c 199 PANTHER PTHR10204:SF16 1 182 2.6E-64 T 21-04-2016 SPH21_RS23400 7f360f52c92ac297ffcb16b061d0d51c 199 SUPERFAMILY SSF52218 1 182 1.38E-52 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS23400 7f360f52c92ac297ffcb16b061d0d51c 199 Pfam PF02525 Flavodoxin-like fold 3 195 2.2E-46 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS23400 7f360f52c92ac297ffcb16b061d0d51c 199 Gene3D G3DSA:3.40.50.360 1 192 1.1E-61 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS23400 7f360f52c92ac297ffcb16b061d0d51c 199 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 2 197 29.785 T 21-04-2016 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 SPH21_RS23400 7f360f52c92ac297ffcb16b061d0d51c 199 PANTHER PTHR10204 1 182 2.6E-64 T 21-04-2016 SPH21_RS25485 34a5907c576bcc03c7a1e4084b19cd4f 256 Gene3D G3DSA:3.40.1210.10 5 253 4.6E-84 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS25485 34a5907c576bcc03c7a1e4084b19cd4f 256 SUPERFAMILY SSF64167 7 252 1.83E-76 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS25485 34a5907c576bcc03c7a1e4084b19cd4f 256 TIGRFAM TIGR00087 surE: 5'/3'-nucleotidase SurE 7 241 7.3E-59 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS25485 34a5907c576bcc03c7a1e4084b19cd4f 256 Hamap MF_00060 5'/3'-nucleotidase SurE [surE]. 6 256 32.937 T 21-04-2016 IPR030048 Survival protein SurE GO:0008252 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS25485 34a5907c576bcc03c7a1e4084b19cd4f 256 Pfam PF01975 Survival protein SurE 8 191 1.5E-55 T 21-04-2016 IPR002828 Survival protein SurE-like phosphatase/nucleotidase GO:0016787 KEGG: 00230+3.1.3.5|KEGG: 00240+3.1.3.5|KEGG: 00760+3.1.3.5|MetaCyc: PWY-5381|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-7185 SPH21_RS25485 34a5907c576bcc03c7a1e4084b19cd4f 256 PANTHER PTHR30457 1 256 1.9E-79 T 21-04-2016 SPH21_RS16635 b007cb96d8e7652aa96cd6fcbde1a144 382 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 1 382 45.727 T 21-04-2016 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 SPH21_RS16635 b007cb96d8e7652aa96cd6fcbde1a144 382 PANTHER PTHR11993:SF28 7 377 2.8E-159 T 21-04-2016 SPH21_RS16635 b007cb96d8e7652aa96cd6fcbde1a144 382 SUPERFAMILY SSF56762 18 382 6.67E-111 T 21-04-2016 IPR029014 NiFe hydrogenase-like SPH21_RS16635 b007cb96d8e7652aa96cd6fcbde1a144 382 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 124 382 1.6E-89 T 21-04-2016 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 SPH21_RS16635 b007cb96d8e7652aa96cd6fcbde1a144 382 PANTHER PTHR11993 7 377 2.8E-159 T 21-04-2016 SPH21_RS16635 b007cb96d8e7652aa96cd6fcbde1a144 382 Gene3D G3DSA:1.10.645.10 4 239 2.1E-38 T 21-04-2016 IPR029014 NiFe hydrogenase-like SPH21_RS16635 b007cb96d8e7652aa96cd6fcbde1a144 382 Gene3D G3DSA:1.10.645.10 240 368 8.5E-12 T 21-04-2016 IPR029014 NiFe hydrogenase-like SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 PANTHER PTHR30363 1 249 3.3E-61 T 21-04-2016 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 SUPERFAMILY SSF100950 73 233 4.65E-25 T 21-04-2016 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 SMART SM00420 6 58 2.6E-14 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 Pfam PF08220 DeoR-like helix-turn-helix domain 6 60 1.2E-14 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 Pfam PF00455 DeoR C terminal sensor domain 74 230 2.6E-40 T 21-04-2016 IPR014036 DeoR C-terminal sensor domain SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 SUPERFAMILY SSF46785 5 60 2.99E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 PANTHER PTHR30363:SF1 1 249 3.3E-61 T 21-04-2016 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 21-04-2016 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 SMART SM01134 71 232 1.3E-50 T 21-04-2016 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 Gene3D G3DSA:3.40.50.1360 74 207 1.8E-9 T 21-04-2016 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 6.6E-8 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 6.6E-8 T 21-04-2016 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SPH21_RS16990 1082c3b977627ef1a607a19fde9a80a5 249 Gene3D G3DSA:1.10.10.10 1 55 1.6E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 Pfam PF11799 impB/mucB/samB family C-terminal domain 237 346 5.8E-15 T 21-04-2016 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 SUPERFAMILY SSF56672 4 235 7.83E-74 T 21-04-2016 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 Hamap MF_01113 DNA polymerase IV [dinB]. 4 349 31.163 T 21-04-2016 IPR022880 DNA polymerase IV GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 PANTHER PTHR11076 7 341 6.1E-104 T 21-04-2016 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 Pfam PF00817 impB/mucB/samB family 11 155 1.9E-46 T 21-04-2016 IPR001126 UmuC domain GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 SUPERFAMILY SSF100879 239 338 7.65E-19 T 21-04-2016 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 Gene3D G3DSA:3.30.70.270 68 162 2.5E-24 T 21-04-2016 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 Gene3D G3DSA:1.10.150.20 168 239 4.6E-18 T 21-04-2016 SPH21_RS17080 1a8fb5db97a6285e2cf1ab6c7366c166 385 Gene3D G3DSA:3.30.1490.100 242 346 2.4E-19 T 21-04-2016 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS21565 b19532d4270567f62128817157fb94e1 147 Gene3D G3DSA:3.10.180.10 2 126 1.5E-22 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS21565 b19532d4270567f62128817157fb94e1 147 SUPERFAMILY SSF54593 1 129 6.34E-18 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS21565 b19532d4270567f62128817157fb94e1 147 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 9 124 1.6E-10 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS06795 438916d4e0e35205ea2cdfb852288299 152 SUPERFAMILY SSF69500 1 145 4.71E-52 T 21-04-2016 IPR023509 D-Tyr tRNAtyr deacylase-like domain SPH21_RS06795 438916d4e0e35205ea2cdfb852288299 152 Pfam PF02580 D-Tyr-tRNA(Tyr) deacylase 2 144 5.4E-53 T 21-04-2016 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 SPH21_RS06795 438916d4e0e35205ea2cdfb852288299 152 TIGRFAM TIGR00256 TIGR00256: D-tyrosyl-tRNA(Tyr) deacylase 2 146 2.5E-53 T 21-04-2016 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 SPH21_RS06795 438916d4e0e35205ea2cdfb852288299 152 PANTHER PTHR10472 2 149 1.4E-64 T 21-04-2016 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 SPH21_RS06795 438916d4e0e35205ea2cdfb852288299 152 Hamap MF_00518 D-aminoacyl-tRNA deacylase [dtd]. 1 146 32.69 T 21-04-2016 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 SPH21_RS06795 438916d4e0e35205ea2cdfb852288299 152 Gene3D G3DSA:3.50.80.10 1 145 1.0E-54 T 21-04-2016 IPR023509 D-Tyr tRNAtyr deacylase-like domain SPH21_RS06615 e88268b1e06d9ed56e106a1b5b5aca4e 76 Pfam PF12843 Putative quorum-sensing-regulated virulence factor 4 69 4.7E-30 T 21-04-2016 IPR024530 Putative quorum-sensing-regulated virulence factor SPH21_RS06615 e88268b1e06d9ed56e106a1b5b5aca4e 76 PANTHER PTHR40613 4 73 1.2E-20 T 21-04-2016 SPH21_RS06615 e88268b1e06d9ed56e106a1b5b5aca4e 76 ProDom PD056452 UNCHARACTERIZED BACTERIA SIMILAR YPEB CYTOPLASMIC VCA0163 PRODUCT STM2426 GENE YPO2988 16 69 2.0E-12 T 21-04-2016 IPR024530 Putative quorum-sensing-regulated virulence factor SPH21_RS06615 e88268b1e06d9ed56e106a1b5b5aca4e 76 PANTHER PTHR40613:SF1 4 73 1.2E-20 T 21-04-2016 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00463 E-class P450 group I signature 33 52 1.9E-20 T 21-04-2016 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00463 E-class P450 group I signature 252 278 1.9E-20 T 21-04-2016 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00463 E-class P450 group I signature 378 401 1.9E-20 T 21-04-2016 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00463 E-class P450 group I signature 333 357 1.9E-20 T 21-04-2016 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00463 E-class P450 group I signature 368 378 1.9E-20 T 21-04-2016 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00463 E-class P450 group I signature 232 249 1.9E-20 T 21-04-2016 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 SUPERFAMILY SSF48264 29 427 2.49E-103 T 21-04-2016 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 Reactome: REACT_13433 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 Gene3D G3DSA:1.10.630.10 27 428 6.6E-111 T 21-04-2016 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 Reactome: REACT_13433 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PANTHER PTHR24291:SF46 26 421 3.0E-108 T 21-04-2016 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00385 P450 superfamily signature 294 305 1.2E-13 T 21-04-2016 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 Reactome: REACT_13433 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00385 P450 superfamily signature 378 389 1.2E-13 T 21-04-2016 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 Reactome: REACT_13433 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00385 P450 superfamily signature 369 378 1.2E-13 T 21-04-2016 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 Reactome: REACT_13433 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PRINTS PR00385 P450 superfamily signature 243 260 1.2E-13 T 21-04-2016 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 Reactome: REACT_13433 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 Pfam PF00067 Cytochrome P450 25 421 8.3E-80 T 21-04-2016 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 Reactome: REACT_13433 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 PANTHER PTHR24291 26 421 3.0E-108 T 21-04-2016 SPH21_RS06190 9f733e15da7eb3d1892438e0089e9aa8 432 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 371 380 - T 21-04-2016 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 Reactome: REACT_13433 SPH21_RS06575 a32e7ae16ca31de7eaa837d1517c2786 497 Gene3D G3DSA:3.40.605.10 16 263 1.5E-67 T 21-04-2016 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS06575 a32e7ae16ca31de7eaa837d1517c2786 497 PANTHER PTHR11699:SF144 14 496 3.0E-271 T 21-04-2016 SPH21_RS06575 a32e7ae16ca31de7eaa837d1517c2786 497 SUPERFAMILY SSF53720 16 485 2.62E-126 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS06575 a32e7ae16ca31de7eaa837d1517c2786 497 PANTHER PTHR11699 14 496 3.0E-271 T 21-04-2016 SPH21_RS06575 a32e7ae16ca31de7eaa837d1517c2786 497 Gene3D G3DSA:3.40.309.10 264 444 5.5E-50 T 21-04-2016 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SPH21_RS06575 a32e7ae16ca31de7eaa837d1517c2786 497 Pfam PF00171 Aldehyde dehydrogenase family 16 478 6.2E-130 T 21-04-2016 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SPH21_RS06575 a32e7ae16ca31de7eaa837d1517c2786 497 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 249 256 - T 21-04-2016 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 295 311 4.1E-11 T 21-04-2016 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 4 26 4.1E-11 T 21-04-2016 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 280 295 4.1E-11 T 21-04-2016 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 146 161 4.1E-11 T 21-04-2016 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 SUPERFAMILY SSF51905 3 167 1.73E-47 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 SUPERFAMILY SSF51905 267 346 1.73E-47 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 PANTHER PTHR13789 1 361 2.0E-95 T 21-04-2016 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 PANTHER PTHR13789:SF246 1 361 2.0E-95 T 21-04-2016 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 Pfam PF01494 FAD binding domain 4 316 2.3E-16 T 21-04-2016 IPR002938 FAD-binding domain GO:0071949 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 Gene3D G3DSA:3.50.50.60 1 172 1.0E-31 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS01440 e967f9b0a300bd0b7dfa9ba4df2d4337 372 Gene3D G3DSA:3.50.50.60 268 343 1.0E-31 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06275 cbf1ec6ce2b751075947bca95b87b972 550 Gene3D G3DSA:3.50.50.60 25 197 5.9E-17 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06275 cbf1ec6ce2b751075947bca95b87b972 550 Pfam PF12831 FAD dependent oxidoreductase 28 538 8.3E-139 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS06275 cbf1ec6ce2b751075947bca95b87b972 550 SUPERFAMILY SSF51905 25 207 2.2E-10 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS14310 bdc0a944f0e9982c769f2e17d4f08e84 326 Gene3D G3DSA:3.20.20.150 34 323 7.6E-54 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14310 bdc0a944f0e9982c769f2e17d4f08e84 326 PANTHER PTHR40117 29 326 1.3E-39 T 21-04-2016 SPH21_RS14310 bdc0a944f0e9982c769f2e17d4f08e84 326 SUPERFAMILY SSF51658 36 321 1.66E-37 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14310 bdc0a944f0e9982c769f2e17d4f08e84 326 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 2 25 6.4E-4 T 21-04-2016 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SPH21_RS14310 bdc0a944f0e9982c769f2e17d4f08e84 326 Pfam PF01261 Xylose isomerase-like TIM barrel 60 246 1.5E-16 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 Gene3D G3DSA:2.40.50.40 138 206 2.1E-24 T 21-04-2016 SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 Gene3D G3DSA:3.40.50.2300 1 124 3.8E-26 T 21-04-2016 SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 SUPERFAMILY SSF52172 1 140 4.13E-27 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 PANTHER PTHR26402 2 128 5.6E-26 T 21-04-2016 SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 PANTHER PTHR26402 210 226 5.6E-26 T 21-04-2016 SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 Pfam PF00072 Response regulator receiver domain 5 110 9.1E-18 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 SMART SM00448 2 110 5.1E-20 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 Pfam PF04397 LytTr DNA-binding domain 147 236 2.0E-19 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS06880 7ba4b5ac12585e4e9360f23815dde533 241 SMART SM00850 146 237 1.1E-24 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS20435 99c0d52476c2d0008169facc17686458 614 PANTHER PTHR31817:SF4 431 591 4.2E-30 T 21-04-2016 SPH21_RS20435 99c0d52476c2d0008169facc17686458 614 Pfam PF08014 Domain of unknown function (DUF1704) 266 594 1.0E-92 T 21-04-2016 IPR012548 Protein of unknown function DUF1704 SPH21_RS20435 99c0d52476c2d0008169facc17686458 614 PANTHER PTHR31817 431 591 4.2E-30 T 21-04-2016 SPH21_RS20435 99c0d52476c2d0008169facc17686458 614 SMART SM01154 265 611 4.4E-99 T 21-04-2016 IPR012548 Protein of unknown function DUF1704 SPH21_RS19590 1418d7f4c3eca17184a218d3af4f2b69 285 SUPERFAMILY SSF51658 35 281 1.8E-36 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS19590 1418d7f4c3eca17184a218d3af4f2b69 285 PANTHER PTHR12110 31 284 2.2E-23 T 21-04-2016 SPH21_RS19590 1418d7f4c3eca17184a218d3af4f2b69 285 Gene3D G3DSA:3.20.20.150 35 281 2.3E-43 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS19590 1418d7f4c3eca17184a218d3af4f2b69 285 Pfam PF01261 Xylose isomerase-like TIM barrel 82 237 4.3E-15 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS20250 7f32784f1f2707b69d5378ba4f458541 369 PANTHER PTHR30294 1 368 2.4E-88 T 21-04-2016 SPH21_RS20250 7f32784f1f2707b69d5378ba4f458541 369 Pfam PF12698 ABC-2 family transporter protein 20 362 3.0E-45 T 21-04-2016 SPH21_RS20250 7f32784f1f2707b69d5378ba4f458541 369 PANTHER PTHR30294:SF12 1 368 2.4E-88 T 21-04-2016 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 PANTHER PTHR11349 5 138 1.5E-55 T 21-04-2016 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 Pfam PF00334 Nucleoside diphosphate kinase 4 135 4.2E-50 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 Gene3D G3DSA:3.30.70.141 2 136 1.2E-54 T 21-04-2016 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 SMART SM00562 3 137 1.9E-63 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 SUPERFAMILY SSF54919 1 137 1.96E-52 T 21-04-2016 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 Hamap MF_00451 Nucleoside diphosphate kinase [ndk]. 3 139 29.846 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 PRINTS PR01243 Nucleoside diphosphate kinase signature 91 107 3.8E-31 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 PRINTS PR01243 Nucleoside diphosphate kinase signature 70 87 3.8E-31 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 PRINTS PR01243 Nucleoside diphosphate kinase signature 6 28 3.8E-31 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 PRINTS PR01243 Nucleoside diphosphate kinase signature 50 69 3.8E-31 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS06100 3947db9e92aae6b247f2f4269a83f66f 139 PRINTS PR01243 Nucleoside diphosphate kinase signature 114 133 3.8E-31 T 21-04-2016 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 Gene3D G3DSA:3.40.50.300 332 571 3.4E-73 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 SMART SM00382 355 543 1.6E-15 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 Gene3D G3DSA:1.20.1560.10 9 317 8.9E-32 T 21-04-2016 SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 ProSitePatterns PS00211 ABC transporters family signature. 467 481 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 PANTHER PTHR24222 1 573 1.1E-128 T 21-04-2016 SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 Pfam PF00664 ABC transporter transmembrane region 18 279 1.2E-12 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 SUPERFAMILY SSF90123 7 314 8.24E-37 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 Pfam PF00005 ABC transporter 347 494 1.4E-30 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS21930 f1c88034d25cf657e9c03d4b6faeaea7 576 SUPERFAMILY SSF52540 327 565 1.96E-77 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13140 2beabf962a32908c1fed8533f4cd0b51 650 Pfam PF07980 SusD family 291 649 1.1E-42 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13140 2beabf962a32908c1fed8533f4cd0b51 650 SUPERFAMILY SSF48452 357 649 3.29E-82 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13140 2beabf962a32908c1fed8533f4cd0b51 650 SUPERFAMILY SSF48452 21 326 3.29E-82 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13140 2beabf962a32908c1fed8533f4cd0b51 650 Gene3D G3DSA:1.25.40.10 207 307 1.3E-25 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13140 2beabf962a32908c1fed8533f4cd0b51 650 Gene3D G3DSA:1.25.40.10 463 574 1.3E-25 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13140 2beabf962a32908c1fed8533f4cd0b51 650 Gene3D G3DSA:1.25.40.10 358 372 1.3E-25 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13140 2beabf962a32908c1fed8533f4cd0b51 650 Pfam PF14322 Starch-binding associating with outer membrane 52 224 9.6E-16 T 21-04-2016 SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PANTHER PTHR24322 148 179 8.3E-49 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PANTHER PTHR24322 7 132 8.3E-49 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 5.1E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 5.1E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 5.1E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 5.1E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 5.1E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 122 138 5.1E-28 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 7.1E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 128 136 7.1E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 7.1E-13 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS07315 65130b44677576fe6af3d51893073900 296 Gene3D G3DSA:3.40.50.720 2 245 4.6E-67 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07315 65130b44677576fe6af3d51893073900 296 SUPERFAMILY SSF51735 2 244 4.66E-64 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS07315 65130b44677576fe6af3d51893073900 296 Pfam PF00106 short chain dehydrogenase 3 187 7.5E-53 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02200 b4fb91fc8f0695ae8ef65507b698f01c 400 Gene3D G3DSA:3.20.20.150 58 270 3.5E-4 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS02200 b4fb91fc8f0695ae8ef65507b698f01c 400 SUPERFAMILY SSF51658 38 293 7.46E-20 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS08405 f57a7e4e41b7cd6dfaa9ebdbee47d3bd 179 Gene3D G3DSA:1.10.357.10 1 142 1.3E-16 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS08405 f57a7e4e41b7cd6dfaa9ebdbee47d3bd 179 SUPERFAMILY SSF46689 1 52 6.98E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08405 f57a7e4e41b7cd6dfaa9ebdbee47d3bd 179 Pfam PF00440 Bacterial regulatory proteins, tetR family 1 27 2.1E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS07720 7ec16675432e58a07037e9de233ffc8f 120 Pfam PF03626 Prokaryotic Cytochrome C oxidase subunit IV 25 102 8.7E-17 T 21-04-2016 IPR005171 Cytochrome C oxidase subunit IV, prokaryotes GO:0016021 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 SUPERFAMILY SSF56935 136 455 1.33E-16 T 21-04-2016 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 SUPERFAMILY SSF56935 728 891 1.33E-16 T 21-04-2016 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 SUPERFAMILY SSF56935 594 683 1.33E-16 T 21-04-2016 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 SUPERFAMILY SSF49464 18 109 2.35E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 Gene3D G3DSA:2.60.40.1120 18 108 4.3E-9 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 Gene3D G3DSA:2.40.170.20 296 476 1.9E-5 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 Gene3D G3DSA:2.40.170.20 544 822 1.9E-5 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 Gene3D G3DSA:2.40.170.20 216 261 1.9E-5 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 Pfam PF13620 Carboxypeptidase regulatory-like domain 18 83 1.0E-10 T 21-04-2016 SPH21_RS10930 ec8fd4fc16d9b53eaebb2b049b26b150 900 Pfam PF14905 Outer membrane protein beta-barrel family 432 889 1.1E-37 T 21-04-2016 SPH21_RS04100 53b742beede4bb4fb3c0010c78a61f05 140 Pfam PF01042 Endoribonuclease L-PSP 30 139 2.8E-26 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS04100 53b742beede4bb4fb3c0010c78a61f05 140 Gene3D G3DSA:3.30.1330.40 31 139 2.4E-30 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS04100 53b742beede4bb4fb3c0010c78a61f05 140 PANTHER PTHR11803 33 140 7.2E-31 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS04100 53b742beede4bb4fb3c0010c78a61f05 140 SUPERFAMILY SSF55298 32 140 4.87E-30 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS13595 db23a867c9ff5dba1180202b038f28b5 161 Gene3D G3DSA:1.20.120.450 12 152 5.2E-16 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS13595 db23a867c9ff5dba1180202b038f28b5 161 SUPERFAMILY SSF109854 12 158 8.24E-31 T 21-04-2016 SPH21_RS13595 db23a867c9ff5dba1180202b038f28b5 161 Pfam PF05163 DinB family 14 157 1.1E-10 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS20855 ad5798ca1fdee5ca125532c75828dfe3 362 Pfam PF14606 GDSL-like Lipase/Acylhydrolase family 178 353 7.1E-57 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS20855 ad5798ca1fdee5ca125532c75828dfe3 362 Pfam PF14607 N-terminus of Esterase_SGNH_hydro-type 29 170 2.6E-41 T 21-04-2016 IPR032740 SGNH hydrolase-type esterase, N-terminal SPH21_RS20855 ad5798ca1fdee5ca125532c75828dfe3 362 Gene3D G3DSA:3.40.50.1110 176 353 3.3E-15 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS20855 ad5798ca1fdee5ca125532c75828dfe3 362 SUPERFAMILY SSF52266 174 357 8.25E-19 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21605 594b191b8629e42fd747ced932969341 304 SUPERFAMILY SSF51215 49 171 1.57E-7 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21605 594b191b8629e42fd747ced932969341 304 SUPERFAMILY SSF46689 255 301 9.86E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21605 594b191b8629e42fd747ced932969341 304 SMART SM00342 215 299 8.9E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21605 594b191b8629e42fd747ced932969341 304 PANTHER PTHR11019 47 300 2.7E-20 T 21-04-2016 SPH21_RS21605 594b191b8629e42fd747ced932969341 304 Gene3D G3DSA:1.10.10.60 254 301 4.9E-13 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21605 594b191b8629e42fd747ced932969341 304 Gene3D G3DSA:2.60.120.280 49 167 2.7E-6 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS21605 594b191b8629e42fd747ced932969341 304 PANTHER PTHR11019:SF50 47 300 2.7E-20 T 21-04-2016 SPH21_RS21605 594b191b8629e42fd747ced932969341 304 Pfam PF12833 Helix-turn-helix domain 225 300 3.9E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS07015 1be211eb784256d621093b10902ef377 134 PANTHER PTHR33452 1 132 8.4E-16 T 21-04-2016 SPH21_RS07015 1be211eb784256d621093b10902ef377 134 Pfam PF07681 DoxX 14 98 2.9E-16 T 21-04-2016 IPR032808 DoxX family SPH21_RS15160 322b42aff778f4a5abb5480921cd0fa0 283 Pfam PF06325 Ribosomal protein L11 methyltransferase (PrmA) 42 277 1.5E-49 T 21-04-2016 SPH21_RS15160 322b42aff778f4a5abb5480921cd0fa0 283 PANTHER PTHR18895:SF3 54 244 3.6E-45 T 21-04-2016 SPH21_RS15160 322b42aff778f4a5abb5480921cd0fa0 283 Gene3D G3DSA:3.40.50.150 110 272 7.8E-37 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS15160 322b42aff778f4a5abb5480921cd0fa0 283 SUPERFAMILY SSF53335 57 273 2.86E-43 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS15160 322b42aff778f4a5abb5480921cd0fa0 283 Hamap MF_00735 Ribosomal protein L11 methyltransferase [prmA]. 3 278 26.459 T 21-04-2016 IPR004498 Ribosomal protein L11 methyltransferase GO:0006479|GO:0008276 SPH21_RS15160 322b42aff778f4a5abb5480921cd0fa0 283 PANTHER PTHR18895 54 244 3.6E-45 T 21-04-2016 SPH21_RS26265 8f7157f8c669b523cd86404e00fd2ad7 66 TIGRFAM TIGR01411 tatAE: twin arginine-targeting protein translocase, TatA/E family 12 55 8.9E-16 T 21-04-2016 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 SPH21_RS26265 8f7157f8c669b523cd86404e00fd2ad7 66 PANTHER PTHR33162:SF1 8 65 1.2E-14 T 21-04-2016 SPH21_RS26265 8f7157f8c669b523cd86404e00fd2ad7 66 PANTHER PTHR33162 8 65 1.2E-14 T 21-04-2016 SPH21_RS26265 8f7157f8c669b523cd86404e00fd2ad7 66 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA]. 9 63 15.202 T 21-04-2016 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 SPH21_RS26265 8f7157f8c669b523cd86404e00fd2ad7 66 Pfam PF02416 mttA/Hcf106 family 12 57 1.2E-16 T 21-04-2016 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 SPH21_RS00320 0fc58a88485ba8064072ef4b00a56b6e 76 Pfam PF04972 BON domain 17 62 4.1E-9 T 21-04-2016 IPR007055 BON domain SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PANTHER PTHR11958:SF26 52 465 1.3E-165 T 21-04-2016 IPR033380 Glutamate-aspartate symport protein GltP/GltT GO:0015293|GO:0015810|GO:0015813|GO:0016021 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 ProSitePatterns PS00714 Sodium:dicarboxylate symporter family signature 2. 337 360 - T 21-04-2016 IPR018107 Sodium:dicarboxylate symporter, conserved site Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 Gene3D G3DSA:1.10.3860.10 52 446 1.3E-115 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 SUPERFAMILY SSF118215 56 443 4.84E-110 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PRINTS PR00173 Glutamate-aspartate symporter signature 396 416 1.5E-26 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PRINTS PR00173 Glutamate-aspartate symporter signature 54 74 1.5E-26 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PRINTS PR00173 Glutamate-aspartate symporter signature 369 388 1.5E-26 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PRINTS PR00173 Glutamate-aspartate symporter signature 334 360 1.5E-26 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PRINTS PR00173 Glutamate-aspartate symporter signature 121 146 1.5E-26 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PRINTS PR00173 Glutamate-aspartate symporter signature 234 253 1.5E-26 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 PANTHER PTHR11958 52 465 1.3E-165 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS16425 53dc3e234c9d4f4eb2ddd1a5726758c4 468 Pfam PF00375 Sodium:dicarboxylate symporter family 56 442 3.7E-115 T 21-04-2016 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 Reactome: REACT_15518|Reactome: REACT_19419 SPH21_RS14050 2251bf63682deab7f44173898fb6299c 76 PANTHER PTHR12599 2 76 2.0E-26 T 21-04-2016 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SPH21_RS14050 2251bf63682deab7f44173898fb6299c 76 Gene3D G3DSA:3.30.1360.20 2 75 1.7E-29 T 21-04-2016 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SPH21_RS14050 2251bf63682deab7f44173898fb6299c 76 Pfam PF01329 Pterin 4 alpha carbinolamine dehydratase 2 75 1.7E-25 T 21-04-2016 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SPH21_RS14050 2251bf63682deab7f44173898fb6299c 76 SUPERFAMILY SSF55248 2 75 8.37E-28 T 21-04-2016 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SPH21_RS26480 cfd50b8435c3a8e0a8f47c6c2a383061 335 SMART SM00255 8 161 0.003 T 21-04-2016 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SPH21_RS26480 cfd50b8435c3a8e0a8f47c6c2a383061 335 Pfam PF13676 TIR domain 11 120 1.4E-18 T 21-04-2016 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SPH21_RS26480 cfd50b8435c3a8e0a8f47c6c2a383061 335 SUPERFAMILY SSF52200 7 120 1.83E-18 T 21-04-2016 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SPH21_RS26480 cfd50b8435c3a8e0a8f47c6c2a383061 335 Gene3D G3DSA:3.40.50.10140 8 136 6.3E-11 T 21-04-2016 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SPH21_RS11875 5c56b3d1d47dcb198d2088dc267ff874 64 Gene3D G3DSA:1.20.5.1030 2 59 1.6E-16 T 21-04-2016 SPH21_RS11875 5c56b3d1d47dcb198d2088dc267ff874 64 Pfam PF00584 SecE/Sec61-gamma subunits of protein translocation complex 6 58 2.9E-17 T 21-04-2016 IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit GO:0006605|GO:0006886|GO:0016020 SPH21_RS11875 5c56b3d1d47dcb198d2088dc267ff874 64 TIGRFAM TIGR00964 secE_bact: preprotein translocase, SecE subunit 6 59 4.6E-11 T 21-04-2016 IPR005807 SecE subunit of protein translocation complex GO:0009306|GO:0015450|GO:0016021 SPH21_RS11875 5c56b3d1d47dcb198d2088dc267ff874 64 Hamap MF_00422 Protein translocase subunit SecE [secE]. 2 58 10.993 T 21-04-2016 IPR022943 Preprotein translocase subunit SecE SPH21_RS14745 2cd1e28920d2f909de4f1404eb154155 405 Pfam PF03841 L-seryl-tRNA selenium transferase 157 301 3.8E-6 T 21-04-2016 IPR018319 L-seryl-tRNA selenium transferase-like KEGG: 00450+2.9.1.1|KEGG: 00970+2.9.1.1|UniPathway: UPA00906 SPH21_RS14745 2cd1e28920d2f909de4f1404eb154155 405 Gene3D G3DSA:3.40.640.10 84 290 4.0E-22 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS14745 2cd1e28920d2f909de4f1404eb154155 405 SUPERFAMILY SSF53383 58 372 7.32E-30 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS14745 2cd1e28920d2f909de4f1404eb154155 405 PANTHER PTHR32328 140 405 4.9E-22 T 21-04-2016 SPH21_RS14745 2cd1e28920d2f909de4f1404eb154155 405 PANTHER PTHR32328 35 121 4.9E-22 T 21-04-2016 SPH21_RS14960 f79573b7468a8615128404ac9132fd2c 307 PANTHER PTHR12737:SF21 6 305 1.9E-85 T 21-04-2016 SPH21_RS14960 f79573b7468a8615128404ac9132fd2c 307 Gene3D G3DSA:3.75.10.10 6 297 9.0E-20 T 21-04-2016 SPH21_RS14960 f79573b7468a8615128404ac9132fd2c 307 PANTHER PTHR12737 6 305 1.9E-85 T 21-04-2016 IPR033199 Dimethylarginine dimethylaminohydrolase/arginine deiminase KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981|UniPathway: UPA00254 SPH21_RS14960 f79573b7468a8615128404ac9132fd2c 307 SUPERFAMILY SSF55909 5 298 1.37E-43 T 21-04-2016 SPH21_RS14960 f79573b7468a8615128404ac9132fd2c 307 PIRSF PIRSF028188 1 303 3.3E-109 T 21-04-2016 IPR014541 Predicted amidinotransferase, FN0238 type SPH21_RS14960 f79573b7468a8615128404ac9132fd2c 307 Pfam PF02274 Amidinotransferase 9 300 8.6E-75 T 21-04-2016 SPH21_RS14905 f6aab313fd3de765c8ad714ef8b3d1d1 166 Gene3D G3DSA:1.10.10.10 14 90 6.5E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14905 f6aab313fd3de765c8ad714ef8b3d1d1 166 PANTHER PTHR33202 7 148 1.7E-36 T 21-04-2016 SPH21_RS14905 f6aab313fd3de765c8ad714ef8b3d1d1 166 Pfam PF01475 Ferric uptake regulator family 21 140 1.6E-30 T 21-04-2016 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 SPH21_RS14905 f6aab313fd3de765c8ad714ef8b3d1d1 166 SUPERFAMILY SSF46785 14 144 9.07E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS08500 501b31f3d7a6d2915f97f945a1ca52f0 209 SUPERFAMILY SSF52166 1 207 2.75E-73 T 21-04-2016 IPR023574 Ribosomal protein L4 domain GO:0003735|GO:0005840|GO:0006412 SPH21_RS08500 501b31f3d7a6d2915f97f945a1ca52f0 209 TIGRFAM TIGR03953 rplD_bact: 50S ribosomal protein uL4 17 205 1.4E-72 T 21-04-2016 IPR013005 50S ribosomal protein uL4 SPH21_RS08500 501b31f3d7a6d2915f97f945a1ca52f0 209 Hamap MF_01328_B 50S ribosomal protein L4 [rplD]. 9 208 31.538 T 21-04-2016 IPR013005 50S ribosomal protein uL4 SPH21_RS08500 501b31f3d7a6d2915f97f945a1ca52f0 209 Pfam PF00573 Ribosomal protein L4/L1 family 17 205 8.1E-63 T 21-04-2016 IPR002136 Ribosomal protein L4/L1e GO:0003735|GO:0005840|GO:0006412 SPH21_RS08500 501b31f3d7a6d2915f97f945a1ca52f0 209 Gene3D G3DSA:3.40.1370.10 58 207 8.1E-58 T 21-04-2016 IPR023574 Ribosomal protein L4 domain GO:0003735|GO:0005840|GO:0006412 SPH21_RS08500 501b31f3d7a6d2915f97f945a1ca52f0 209 PANTHER PTHR10746 1 206 3.6E-77 T 21-04-2016 IPR013005 50S ribosomal protein uL4 SPH21_RS22770 fbb485d4f19c1d78deb8e3cfee46e8b0 127 Pfam PF01475 Ferric uptake regulator family 5 94 5.9E-9 T 21-04-2016 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 SPH21_RS22770 fbb485d4f19c1d78deb8e3cfee46e8b0 127 Gene3D G3DSA:1.10.10.10 5 69 8.6E-11 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22770 fbb485d4f19c1d78deb8e3cfee46e8b0 127 SUPERFAMILY SSF46785 4 123 1.27E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14690 59dbf2025851803f645ac680bf832201 313 Pfam PF01261 Xylose isomerase-like TIM barrel 64 264 5.9E-30 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14690 59dbf2025851803f645ac680bf832201 313 Gene3D G3DSA:3.20.20.150 42 311 3.1E-47 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14690 59dbf2025851803f645ac680bf832201 313 SUPERFAMILY SSF51658 30 311 1.57E-44 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS14690 59dbf2025851803f645ac680bf832201 313 PANTHER PTHR12110:SF21 35 312 1.1E-51 T 21-04-2016 SPH21_RS14690 59dbf2025851803f645ac680bf832201 313 PANTHER PTHR12110 35 312 1.1E-51 T 21-04-2016 SPH21_RS00750 258fb0434078439a33af9b4b85090012 539 Pfam PF00578 AhpC/TSA family 152 234 2.5E-7 T 21-04-2016 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS00750 258fb0434078439a33af9b4b85090012 539 SUPERFAMILY SSF52833 148 271 2.61E-17 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS00750 258fb0434078439a33af9b4b85090012 539 Gene3D G3DSA:3.40.30.10 124 270 4.4E-22 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 PANTHER PTHR30572 396 786 7.0E-65 T 21-04-2016 SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 PANTHER PTHR30572 284 351 7.0E-65 T 21-04-2016 SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 PANTHER PTHR30572:SF4 396 786 7.0E-65 T 21-04-2016 SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 PANTHER PTHR30572:SF4 284 351 7.0E-65 T 21-04-2016 SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 Pfam PF02687 FtsX-like permease family 666 778 3.0E-13 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 Pfam PF02687 FtsX-like permease family 285 400 3.3E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 Pfam PF12704 MacB-like periplasmic core domain 20 239 7.8E-22 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS12940 d109f07632cb5571ddd535098bd94d95 786 Pfam PF12704 MacB-like periplasmic core domain 428 625 1.3E-6 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS19330 0f84c261230cc4682e3b2d5c59617d74 282 SUPERFAMILY SSF53067 1 103 5.61E-27 T 21-04-2016 SPH21_RS19330 0f84c261230cc4682e3b2d5c59617d74 282 SUPERFAMILY SSF53067 109 280 3.67E-34 T 21-04-2016 SPH21_RS11750 f3c541981d59becadd913d5a85a64b40 657 Pfam PF12969 Domain of Unknown Function with PDB structure (DUF3857) 69 195 9.5E-10 T 21-04-2016 IPR024618 Domain of unknown function DUF3857 SPH21_RS06885 e8c25b0bb1a1fe2eda265f044777110d 335 Pfam PF06580 Histidine kinase 150 228 2.1E-27 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS06885 e8c25b0bb1a1fe2eda265f044777110d 335 Gene3D G3DSA:3.30.565.10 200 283 5.6E-5 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS06885 e8c25b0bb1a1fe2eda265f044777110d 335 PANTHER PTHR34220 110 335 1.6E-63 T 21-04-2016 SPH21_RS06885 e8c25b0bb1a1fe2eda265f044777110d 335 PANTHER PTHR34220:SF1 110 335 1.6E-63 T 21-04-2016 SPH21_RS10900 0b12d530644d57bc5b6576546a49432c 209 Pfam PF01810 LysE type translocator 13 201 1.1E-27 T 21-04-2016 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SPH21_RS10900 0b12d530644d57bc5b6576546a49432c 209 PANTHER PTHR38825 1 208 2.4E-16 T 21-04-2016 SPH21_RS02360 3f73f41d9307fb957e7e36848f39352f 506 Pfam PF07980 SusD family 273 506 4.3E-32 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS02360 3f73f41d9307fb957e7e36848f39352f 506 Gene3D G3DSA:1.25.40.10 203 317 1.4E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02360 3f73f41d9307fb957e7e36848f39352f 506 Gene3D G3DSA:1.25.40.10 355 442 1.4E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02360 3f73f41d9307fb957e7e36848f39352f 506 Pfam PF14322 Starch-binding associating with outer membrane 25 223 2.9E-19 T 21-04-2016 SPH21_RS02360 3f73f41d9307fb957e7e36848f39352f 506 SUPERFAMILY SSF48452 20 506 1.39E-93 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23795 7d2b76ffb0a8b50239179defb2d111cb 292 Pfam PF12294 Protein of unknown function (DUF3626) 117 194 2.2E-9 T 21-04-2016 IPR022074 Protein of unknown function DUF3626 SPH21_RS23795 7d2b76ffb0a8b50239179defb2d111cb 292 Pfam PF12294 Protein of unknown function (DUF3626) 211 291 1.0E-7 T 21-04-2016 IPR022074 Protein of unknown function DUF3626 SPH21_RS08185 0791bbed204e27df77f872bceac4973f 172 PANTHER PTHR10173:SF34 3 154 1.8E-82 T 21-04-2016 SPH21_RS08185 0791bbed204e27df77f872bceac4973f 172 Pfam PF01625 Peptide methionine sulfoxide reductase 2 154 4.3E-67 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS08185 0791bbed204e27df77f872bceac4973f 172 SUPERFAMILY SSF55068 2 166 4.45E-75 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS08185 0791bbed204e27df77f872bceac4973f 172 PANTHER PTHR10173 3 154 1.8E-82 T 21-04-2016 IPR028427 Peptide methionine sulfoxide reductase GO:0006979|GO:0016671|GO:0030091 SPH21_RS08185 0791bbed204e27df77f872bceac4973f 172 Hamap MF_01401 Peptide methionine sulfoxide reductase MsrA [msrA]. 1 159 36.832 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS08185 0791bbed204e27df77f872bceac4973f 172 TIGRFAM TIGR00401 msrA: peptide-methionine (S)-S-oxide reductase 2 151 2.6E-64 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS08185 0791bbed204e27df77f872bceac4973f 172 Gene3D G3DSA:3.30.1060.10 2 154 2.3E-74 T 21-04-2016 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 SPH21_RS19660 1beb49b8cbe7481777e280498ebcca85 324 Gene3D G3DSA:1.10.575.10 24 289 3.0E-34 T 21-04-2016 IPR008947 Phospholipase C/P1 nuclease domain GO:0016788 SPH21_RS19660 1beb49b8cbe7481777e280498ebcca85 324 SUPERFAMILY SSF48537 26 271 3.79E-24 T 21-04-2016 IPR008947 Phospholipase C/P1 nuclease domain GO:0016788 SPH21_RS19660 1beb49b8cbe7481777e280498ebcca85 324 Pfam PF02265 S1/P1 Nuclease 26 238 3.0E-6 T 21-04-2016 IPR003154 S1/P1 nuclease GO:0003676|GO:0004519|GO:0006308 SPH21_RS24505 a56678ab42732fa3ad0af3a75d911516 756 Gene3D G3DSA:3.90.226.10 562 755 3.2E-26 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS24505 a56678ab42732fa3ad0af3a75d911516 756 SMART SM00245 521 734 0.0027 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS24505 a56678ab42732fa3ad0af3a75d911516 756 SUPERFAMILY SSF52096 548 755 2.32E-31 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS24505 a56678ab42732fa3ad0af3a75d911516 756 SUPERFAMILY SSF52096 374 444 2.32E-31 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS24505 a56678ab42732fa3ad0af3a75d911516 756 Gene3D G3DSA:2.30.42.10 456 534 8.4E-5 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS24505 a56678ab42732fa3ad0af3a75d911516 756 Pfam PF03572 Peptidase family S41 570 732 1.6E-14 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS23215 21f044ba795a980915f2bf6acc43e19c 535 Pfam PF07980 SusD family 267 535 8.9E-27 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS23215 21f044ba795a980915f2bf6acc43e19c 535 Gene3D G3DSA:1.25.40.10 466 483 7.6E-44 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23215 21f044ba795a980915f2bf6acc43e19c 535 Gene3D G3DSA:1.25.40.10 205 318 7.6E-44 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23215 21f044ba795a980915f2bf6acc43e19c 535 Gene3D G3DSA:1.25.40.10 370 434 7.6E-44 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23215 21f044ba795a980915f2bf6acc43e19c 535 SUPERFAMILY SSF48452 18 434 1.09E-112 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23215 21f044ba795a980915f2bf6acc43e19c 535 SUPERFAMILY SSF48452 466 535 1.09E-112 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23215 21f044ba795a980915f2bf6acc43e19c 535 Pfam PF14322 Starch-binding associating with outer membrane 88 222 2.1E-21 T 21-04-2016 SPH21_RS05605 1d00d5c2fef53e151bab08f3d15f50f6 488 Pfam PF14667 Polysaccharide biosynthesis C-terminal domain 348 469 3.2E-11 T 21-04-2016 IPR029303 Polysaccharide biosynthesis protein, C-terminal domain SPH21_RS05605 1d00d5c2fef53e151bab08f3d15f50f6 488 PANTHER PTHR30250:SF8 1 459 5.5E-22 T 21-04-2016 SPH21_RS05605 1d00d5c2fef53e151bab08f3d15f50f6 488 PANTHER PTHR30250 1 459 5.5E-22 T 21-04-2016 SPH21_RS05605 1d00d5c2fef53e151bab08f3d15f50f6 488 Pfam PF01943 Polysaccharide biosynthesis protein 2 277 2.0E-16 T 21-04-2016 IPR002797 Polysaccharide biosynthesis protein GO:0016020 SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 PANTHER PTHR32282 412 776 5.3E-166 T 21-04-2016 SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 PANTHER PTHR32282 3 330 5.3E-166 T 21-04-2016 SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 SUPERFAMILY SSF53955 49 268 6.19E-63 T 21-04-2016 IPR023346 Lysozyme-like domain SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 Gene3D G3DSA:3.40.710.10 411 723 1.2E-110 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 Gene3D G3DSA:3.40.710.10 248 333 1.2E-110 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 Pfam PF00905 Penicillin binding protein transpeptidase domain 420 702 1.6E-27 T 21-04-2016 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 Gene3D G3DSA:1.10.3810.10 60 247 7.0E-64 T 21-04-2016 SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 SUPERFAMILY SSF56601 413 722 1.5E-107 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 SUPERFAMILY SSF56601 279 333 1.5E-107 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 SUPERFAMILY SSF56601 227 249 1.5E-107 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 PANTHER PTHR32282:SF5 412 776 5.3E-166 T 21-04-2016 SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 PANTHER PTHR32282:SF5 3 330 5.3E-166 T 21-04-2016 SPH21_RS15500 fe879fb1cd9ff6eb448b09de5096e847 776 Pfam PF00912 Transglycosylase 60 246 2.9E-55 T 21-04-2016 IPR001264 Glycosyl transferase, family 51 UniPathway: UPA00219 SPH21_RS23840 fb73a1cb9df245e9e088d06727ab731a 602 Gene3D G3DSA:2.40.50.230 371 447 1.1E-18 T 21-04-2016 IPR006531 Gp5 N-terminal SPH21_RS23840 fb73a1cb9df245e9e088d06727ab731a 602 Gene3D G3DSA:3.55.50.10 106 179 8.3E-7 T 21-04-2016 SPH21_RS23840 fb73a1cb9df245e9e088d06727ab731a 602 SUPERFAMILY SSF69279 16 186 2.66E-23 T 21-04-2016 SPH21_RS23840 fb73a1cb9df245e9e088d06727ab731a 602 Pfam PF05954 Phage late control gene D protein (GPD) 58 180 1.1E-9 T 21-04-2016 SPH21_RS23840 fb73a1cb9df245e9e088d06727ab731a 602 SUPERFAMILY SSF69255 365 447 1.31E-16 T 21-04-2016 SPH21_RS23840 fb73a1cb9df245e9e088d06727ab731a 602 SUPERFAMILY SSF69349 439 599 7.85E-7 T 21-04-2016 SPH21_RS05075 81f2718f03ecc88c3f71222cdad9e3c6 231 Gene3D G3DSA:3.40.630.30 6 149 1.5E-14 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS05075 81f2718f03ecc88c3f71222cdad9e3c6 231 SUPERFAMILY SSF55729 5 140 2.74E-11 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15290 21adbab06074adfcf5e3b0b7879a16aa 352 TIGRFAM TIGR00247 TIGR00247: conserved hypothetical protein, YceG family 16 346 6.8E-48 T 21-04-2016 IPR003770 Uncharacterised protein family UPF0755, YceG-like SPH21_RS15290 21adbab06074adfcf5e3b0b7879a16aa 352 PANTHER PTHR30518 1 352 1.1E-64 T 21-04-2016 SPH21_RS15290 21adbab06074adfcf5e3b0b7879a16aa 352 Gene3D G3DSA:3.30.160.60 311 349 9.9E-6 T 21-04-2016 IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain GO:0003676 SPH21_RS15290 21adbab06074adfcf5e3b0b7879a16aa 352 Pfam PF02618 YceG-like family 52 339 3.9E-64 T 21-04-2016 IPR003770 Uncharacterised protein family UPF0755, YceG-like SPH21_RS15290 21adbab06074adfcf5e3b0b7879a16aa 352 PANTHER PTHR30518:SF2 1 352 1.1E-64 T 21-04-2016 SPH21_RS24585 489cfcc494746da44bc6b1e53a81f63e 115 PANTHER PTHR35810:SF1 5 110 7.2E-31 T 21-04-2016 SPH21_RS24585 489cfcc494746da44bc6b1e53a81f63e 115 Pfam PF13310 Virulence protein RhuM family 26 109 8.2E-27 T 21-04-2016 IPR011204 Virulence protein RhuM-like SPH21_RS24585 489cfcc494746da44bc6b1e53a81f63e 115 PANTHER PTHR35810 5 110 7.2E-31 T 21-04-2016 SPH21_RS14035 c4d2e482f89923ab377becea71d7954f 123 Pfam PF04138 GtrA-like protein 6 120 1.5E-22 T 21-04-2016 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 SPH21_RS01545 03b383b0a380efce82328c6d0165ef98 492 SUPERFAMILY SSF53474 39 465 3.61E-72 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS01545 03b383b0a380efce82328c6d0165ef98 492 Pfam PF00450 Serine carboxypeptidase 69 440 1.0E-12 T 21-04-2016 IPR001563 Peptidase S10, serine carboxypeptidase GO:0004185|GO:0006508 SPH21_RS01545 03b383b0a380efce82328c6d0165ef98 492 Gene3D G3DSA:3.40.50.1820 23 485 2.8E-51 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04650 5380b565236f33123613199238571b63 167 Gene3D G3DSA:1.20.120.450 1 150 1.4E-24 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS04650 5380b565236f33123613199238571b63 167 SUPERFAMILY SSF109854 2 158 3.36E-34 T 21-04-2016 SPH21_RS04650 5380b565236f33123613199238571b63 167 Pfam PF05163 DinB family 5 165 3.9E-14 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS14075 e2dc380e33c20c1e655993639c79fa0e 170 SUPERFAMILY SSF54001 35 168 9.03E-31 T 21-04-2016 SPH21_RS14075 e2dc380e33c20c1e655993639c79fa0e 170 Pfam PF00877 NlpC/P60 family 54 166 7.0E-20 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS14075 e2dc380e33c20c1e655993639c79fa0e 170 Gene3D G3DSA:3.90.1720.10 42 169 3.2E-33 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS14075 e2dc380e33c20c1e655993639c79fa0e 170 PANTHER PTHR21666 45 169 5.0E-16 T 21-04-2016 SPH21_RS23625 b80dff3463e5046b475be78e8c9be92c 291 Gene3D G3DSA:3.40.50.720 1 231 1.9E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23625 b80dff3463e5046b475be78e8c9be92c 291 PANTHER PTHR10366 2 287 1.0E-85 T 21-04-2016 SPH21_RS23625 b80dff3463e5046b475be78e8c9be92c 291 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 77 1.2E-10 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS23625 b80dff3463e5046b475be78e8c9be92c 291 SUPERFAMILY SSF51735 1 281 3.2E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23625 b80dff3463e5046b475be78e8c9be92c 291 PANTHER PTHR10366:SF344 2 287 1.0E-85 T 21-04-2016 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 SUPERFAMILY SSF55347 213 326 6.28E-24 T 21-04-2016 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 SUPERFAMILY SSF51735 4 209 3.61E-61 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 SUPERFAMILY SSF51735 323 369 3.61E-61 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 Gene3D G3DSA:3.30.360.10 214 326 5.8E-35 T 21-04-2016 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 Pfam PF01658 Myo-inositol-1-phosphate synthase 215 326 1.1E-26 T 21-04-2016 IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|UniPathway: UPA00823 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 PANTHER PTHR11510:SF9 136 366 4.6E-96 T 21-04-2016 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 PANTHER PTHR11510:SF9 1 110 4.6E-96 T 21-04-2016 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 PANTHER PTHR11510 136 366 4.6E-96 T 21-04-2016 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|UniPathway: UPA00823 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 PANTHER PTHR11510 1 110 4.6E-96 T 21-04-2016 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|UniPathway: UPA00823 SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 Gene3D G3DSA:3.40.50.720 2 213 6.0E-93 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25130 6ab233172a532da4bc69ec721b1ceabb 400 Gene3D G3DSA:3.40.50.720 327 379 6.0E-93 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS08725 10b91aa4af4a345630f57b8bfcc7ff8f 110 Pfam PF01192 RNA polymerase Rpb6 22 99 4.4E-8 T 21-04-2016 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS08725 10b91aa4af4a345630f57b8bfcc7ff8f 110 SMART SM01409 20 101 7.1E-6 T 21-04-2016 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SPH21_RS02370 156fef520834d2ebd6cd8e306a72a403 603 Pfam PF07980 SusD family 349 603 3.6E-29 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS02370 156fef520834d2ebd6cd8e306a72a403 603 Gene3D G3DSA:1.25.40.10 364 460 2.0E-26 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02370 156fef520834d2ebd6cd8e306a72a403 603 Gene3D G3DSA:1.25.40.10 204 322 2.0E-26 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02370 156fef520834d2ebd6cd8e306a72a403 603 SUPERFAMILY SSF48452 17 488 7.71E-83 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02370 156fef520834d2ebd6cd8e306a72a403 603 SUPERFAMILY SSF48452 569 603 7.71E-83 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02370 156fef520834d2ebd6cd8e306a72a403 603 Pfam PF14322 Starch-binding associating with outer membrane 31 220 1.2E-22 T 21-04-2016 SPH21_RS24245 834360eba39f306acb634d5d36234891 450 Pfam PF07980 SusD family 313 412 3.6E-11 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS24245 834360eba39f306acb634d5d36234891 450 Pfam PF14322 Starch-binding associating with outer membrane 20 223 6.3E-36 T 21-04-2016 SPH21_RS24245 834360eba39f306acb634d5d36234891 450 Gene3D G3DSA:1.25.40.10 206 391 1.1E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24245 834360eba39f306acb634d5d36234891 450 SUPERFAMILY SSF48452 16 450 4.11E-57 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24070 253d41c2feef663b08d36d4b34a22981 145 PANTHER PTHR22769 16 117 2.9E-13 T 21-04-2016 SPH21_RS24070 253d41c2feef663b08d36d4b34a22981 145 SUPERFAMILY SSF55811 11 124 3.79E-21 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS24070 253d41c2feef663b08d36d4b34a22981 145 Gene3D G3DSA:3.90.79.10 11 128 3.1E-19 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS24070 253d41c2feef663b08d36d4b34a22981 145 PRINTS PR00502 NUDIX hydrolase family signature 52 67 8.5E-5 T 21-04-2016 IPR020476 NUDIX hydrolase SPH21_RS24070 253d41c2feef663b08d36d4b34a22981 145 PRINTS PR00502 NUDIX hydrolase family signature 38 52 8.5E-5 T 21-04-2016 IPR020476 NUDIX hydrolase SPH21_RS24070 253d41c2feef663b08d36d4b34a22981 145 Pfam PF00293 NUDIX domain 16 121 7.4E-12 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS25100 9781ee63de5954d2a211413797f0f974 179 Pfam PF02417 Chromate transporter 4 167 5.3E-40 T 21-04-2016 IPR003370 Chromate transporter GO:0015109|GO:0015703 SPH21_RS25100 9781ee63de5954d2a211413797f0f974 179 PANTHER PTHR33567 1 177 8.4E-59 T 21-04-2016 SPH21_RS25100 9781ee63de5954d2a211413797f0f974 179 PANTHER PTHR33567:SF2 1 177 8.4E-59 T 21-04-2016 SPH21_RS06000 d65dc92d506815facbe71331db6fa5b4 209 Gene3D G3DSA:2.60.40.10 149 206 2.4E-11 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS06000 d65dc92d506815facbe71331db6fa5b4 209 Pfam PF00041 Fibronectin type III domain 156 200 6.4E-7 T 21-04-2016 IPR003961 Fibronectin type III GO:0005515 SPH21_RS06000 d65dc92d506815facbe71331db6fa5b4 209 SUPERFAMILY SSF49265 140 205 2.15E-11 T 21-04-2016 IPR003961 Fibronectin type III GO:0005515 SPH21_RS06000 d65dc92d506815facbe71331db6fa5b4 209 SMART SM00060 117 198 2.8E-5 T 21-04-2016 IPR003961 Fibronectin type III GO:0005515 SPH21_RS07380 9c28a8513848338a9df50c88b149e576 109 Gene3D G3DSA:1.10.10.10 6 92 9.4E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS07380 9c28a8513848338a9df50c88b149e576 109 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 6 88 1.2E-23 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS07380 9c28a8513848338a9df50c88b149e576 109 PANTHER PTHR10815 5 105 2.2E-30 T 21-04-2016 SPH21_RS07380 9c28a8513848338a9df50c88b149e576 109 PANTHER PTHR10815:SF2 5 105 2.2E-30 T 21-04-2016 SPH21_RS07380 9c28a8513848338a9df50c88b149e576 109 SUPERFAMILY SSF46767 5 89 2.09E-20 T 21-04-2016 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 SPH21_RS20420 a66eca01d2bc8851129cea45cce77d1c 437 PANTHER PTHR34219 9 402 5.6E-47 T 21-04-2016 SPH21_RS20420 a66eca01d2bc8851129cea45cce77d1c 437 Pfam PF03929 PepSY-associated TM region 19 385 1.8E-62 T 21-04-2016 IPR005625 PepSY-associated TM protein SPH21_RS08285 562a5e6a0d982708c0fb43c02731b39e 449 PANTHER PTHR30026:SF6 16 444 2.8E-55 T 21-04-2016 SPH21_RS08285 562a5e6a0d982708c0fb43c02731b39e 449 Gene3D G3DSA:1.20.1600.10 28 444 3.4E-66 T 21-04-2016 SPH21_RS08285 562a5e6a0d982708c0fb43c02731b39e 449 SUPERFAMILY SSF56954 8 444 6.28E-83 T 21-04-2016 SPH21_RS08285 562a5e6a0d982708c0fb43c02731b39e 449 Pfam PF02321 Outer membrane efflux protein 261 443 2.6E-30 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS08285 562a5e6a0d982708c0fb43c02731b39e 449 Pfam PF02321 Outer membrane efflux protein 35 238 3.8E-30 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS08285 562a5e6a0d982708c0fb43c02731b39e 449 PANTHER PTHR30026 16 444 2.8E-55 T 21-04-2016 SPH21_RS10400 b2b9e36f7c6060262b50cde5f7799573 387 PANTHER PTHR30213:SF1 49 358 1.2E-66 T 21-04-2016 SPH21_RS10400 b2b9e36f7c6060262b50cde5f7799573 387 Pfam PF03631 Virulence factor BrkB 89 344 1.2E-54 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS10400 b2b9e36f7c6060262b50cde5f7799573 387 PANTHER PTHR30213 49 358 1.2E-66 T 21-04-2016 SPH21_RS10400 b2b9e36f7c6060262b50cde5f7799573 387 TIGRFAM TIGR00765 yihY_not_rbn: YihY family inner membrane protein 84 342 8.7E-29 T 21-04-2016 IPR017039 Virulence factor BrkB SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 PANTHER PTHR11019 162 287 1.1E-24 T 21-04-2016 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 PANTHER PTHR11019 1 134 1.1E-24 T 21-04-2016 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 Pfam PF02311 AraC-like ligand binding domain 13 149 2.0E-12 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 SUPERFAMILY SSF51215 18 160 3.53E-14 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 Gene3D G3DSA:1.10.10.60 176 232 7.3E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 Gene3D G3DSA:1.10.10.60 233 282 1.4E-12 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 SUPERFAMILY SSF46689 233 281 1.29E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 Pfam PF12833 Helix-turn-helix domain 202 281 1.5E-16 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 Gene3D G3DSA:2.60.120.280 19 161 7.9E-13 T 21-04-2016 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 SMART SM00342 196 279 4.7E-19 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 263 279 6.2E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS20615 241f12d1d30ba4e295274af3df960ab9 288 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 248 263 6.2E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS01385 30d907c82bc85724bcac95be9e5c41f0 158 SMART SM01235 16 151 6.8E-48 T 21-04-2016 IPR025992 Haem-binding domain SPH21_RS01385 30d907c82bc85724bcac95be9e5c41f0 158 Pfam PF14376 Haem-binding domain 18 148 2.3E-43 T 21-04-2016 IPR025992 Haem-binding domain SPH21_RS18095 c21f75f008134fdd00a5557b41b6b4a8 390 Gene3D G3DSA:2.40.50.100 173 205 1.7E-18 T 21-04-2016 SPH21_RS18095 c21f75f008134fdd00a5557b41b6b4a8 390 Gene3D G3DSA:2.40.50.100 65 98 1.7E-18 T 21-04-2016 SPH21_RS18095 c21f75f008134fdd00a5557b41b6b4a8 390 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 40 370 6.1E-84 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS18095 c21f75f008134fdd00a5557b41b6b4a8 390 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 66 290 1.9E-19 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS18095 c21f75f008134fdd00a5557b41b6b4a8 390 SUPERFAMILY SSF111369 55 294 1.83E-55 T 21-04-2016 SPH21_RS18095 c21f75f008134fdd00a5557b41b6b4a8 390 PANTHER PTHR30158 1 369 4.2E-87 T 21-04-2016 SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 Pfam PF00072 Response regulator receiver domain 6 118 2.5E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 SMART SM00421 143 200 4.0E-5 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 Gene3D G3DSA:3.40.50.2300 2 149 1.4E-22 T 21-04-2016 SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 Pfam PF00196 Bacterial regulatory proteins, luxR family 146 199 7.6E-10 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 PANTHER PTHR26402 3 201 2.4E-35 T 21-04-2016 SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 SUPERFAMILY SSF52172 2 122 1.71E-22 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 Gene3D G3DSA:1.10.10.10 150 206 1.5E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 SUPERFAMILY SSF46894 140 207 2.18E-14 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS10575 f2cda7132bd09dbf896a1539caa0b267 218 SMART SM00448 3 118 6.7E-17 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10865 6ab229869695c8f11144360620825792 183 Pfam PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 18 175 3.8E-28 T 21-04-2016 IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 GO:0008137|GO:0055114 SPH21_RS10865 6ab229869695c8f11144360620825792 183 PANTHER PTHR33269:SF1 1 180 1.1E-35 T 21-04-2016 SPH21_RS10865 6ab229869695c8f11144360620825792 183 PANTHER PTHR33269 1 180 1.1E-35 T 21-04-2016 SPH21_RS12055 5cdda3ffaecf4cda6874b3edbefb4dc6 388 SUPERFAMILY SSF53756 85 371 5.5E-15 T 21-04-2016 SPH21_RS12055 5cdda3ffaecf4cda6874b3edbefb4dc6 388 Pfam PF13692 Glycosyl transferases group 1 223 350 1.9E-17 T 21-04-2016 SPH21_RS06310 845f675271c496e91b2ba888766f144c 115 Pfam PF13788 Domain of unknown function (DUF4180) 9 113 1.5E-40 T 21-04-2016 IPR025438 Domain of unknown function DUF4180 SPH21_RS07360 b40b081888b78548871b56324daa0971 142 Gene3D G3DSA:3.40.630.30 13 130 1.3E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS07360 b40b081888b78548871b56324daa0971 142 SUPERFAMILY SSF55729 26 127 6.35E-19 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS07360 b40b081888b78548871b56324daa0971 142 Pfam PF13508 Acetyltransferase (GNAT) domain 46 122 7.0E-7 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 Pfam PF13662 Toprim domain 82 172 1.5E-24 T 21-04-2016 IPR006171 Toprim domain SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 PANTHER PTHR30446 2 201 1.3E-104 T 21-04-2016 SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 ProSitePatterns PS01300 RecR protein signature. 58 79 - T 21-04-2016 IPR015967 Recombination protein RecR, conserved site GO:0006281|GO:0006310 SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 SUPERFAMILY SSF111304 5 199 2.35E-70 T 21-04-2016 IPR023627 Recombination protein RecR SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 Gene3D G3DSA:1.10.150.20 9 35 4.7E-4 T 21-04-2016 SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 TIGRFAM TIGR00615 recR: recombination protein RecR 5 196 6.1E-72 T 21-04-2016 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 PANTHER PTHR30446:SF0 2 201 1.3E-104 T 21-04-2016 SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 Hamap MF_00017 Recombination protein RecR [recR]. 1 199 90.248 T 21-04-2016 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 SMART SM00493 81 166 8.0E-8 T 21-04-2016 IPR006171 Toprim domain SPH21_RS15415 c4e6051643fac3a0847ccd2890cc0423 204 Pfam PF02132 RecR protein 41 79 1.1E-13 T 21-04-2016 IPR023628 Recombination protein RecR, C4-type zinc finger SPH21_RS06800 822cb85d332c7f23a4e1be95a6897c27 110 PIRSF PIRSF029904 1 108 5.9E-44 T 21-04-2016 IPR012359 NTP pyrophosphohydrolase MazG-related, YpjD SPH21_RS06800 822cb85d332c7f23a4e1be95a6897c27 110 Gene3D G3DSA:1.10.287.1080 1 92 1.1E-24 T 21-04-2016 SPH21_RS06800 822cb85d332c7f23a4e1be95a6897c27 110 PANTHER PTHR14552 1 107 1.2E-28 T 21-04-2016 SPH21_RS06800 822cb85d332c7f23a4e1be95a6897c27 110 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 23 100 4.4E-16 T 21-04-2016 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core SPH21_RS06800 822cb85d332c7f23a4e1be95a6897c27 110 SUPERFAMILY SSF101386 1 100 9.74E-25 T 21-04-2016 SPH21_RS06800 822cb85d332c7f23a4e1be95a6897c27 110 PANTHER PTHR14552:SF13 1 107 1.2E-28 T 21-04-2016 SPH21_RS11300 2e99cd7a4f8af3a128a71d40954ca8e4 306 PANTHER PTHR10491 1 306 8.1E-83 T 21-04-2016 IPR005913 dTDP-4-dehydrorhamnose reductase family SPH21_RS11300 2e99cd7a4f8af3a128a71d40954ca8e4 306 Pfam PF04321 RmlD substrate binding domain 3 298 4.2E-64 T 21-04-2016 IPR029903 RmlD-like substrate binding domain SPH21_RS11300 2e99cd7a4f8af3a128a71d40954ca8e4 306 Gene3D G3DSA:3.40.50.720 1 244 2.2E-52 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS11300 2e99cd7a4f8af3a128a71d40954ca8e4 306 SUPERFAMILY SSF51735 1 299 6.03E-72 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01465 31bd5cf0f4b46fa1bdc2d08d4db0b231 115 Gene3D G3DSA:1.10.10.10 7 110 1.9E-31 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01465 31bd5cf0f4b46fa1bdc2d08d4db0b231 115 SUPERFAMILY SSF46785 13 109 7.56E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01465 31bd5cf0f4b46fa1bdc2d08d4db0b231 115 PANTHER PTHR33204 16 103 3.3E-25 T 21-04-2016 SPH21_RS01465 31bd5cf0f4b46fa1bdc2d08d4db0b231 115 Pfam PF01638 HxlR-like helix-turn-helix 22 107 5.3E-22 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS06505 cf1734e60232f10e72f32b74c758934c 285 SUPERFAMILY SSF53850 3 275 7.38E-78 T 21-04-2016 SPH21_RS06505 cf1734e60232f10e72f32b74c758934c 285 Pfam PF02621 Menaquinone biosynthesis 3 270 1.7E-80 T 21-04-2016 IPR003773 Menaquinone biosynthesis enzyme UniPathway: UPA00079 SPH21_RS06505 cf1734e60232f10e72f32b74c758934c 285 Gene3D G3DSA:3.40.190.10 26 79 2.7E-6 T 21-04-2016 SPH21_RS06505 cf1734e60232f10e72f32b74c758934c 285 Gene3D G3DSA:3.40.190.10 186 283 2.7E-6 T 21-04-2016 SPH21_RS06505 cf1734e60232f10e72f32b74c758934c 285 PANTHER PTHR37167 1 284 1.4E-93 T 21-04-2016 SPH21_RS06505 cf1734e60232f10e72f32b74c758934c 285 Gene3D G3DSA:3.40.190.10 106 185 4.1E-10 T 21-04-2016 SPH21_RS06505 cf1734e60232f10e72f32b74c758934c 285 Hamap MF_00996 1,4-dihydroxy-6-naphtoate synthase [mqnD]. 2 276 40.416 T 21-04-2016 IPR030869 1,4-dihydroxy-6-naphtoate synthase GO:0009234|GO:0016829 UniPathway: UPA00079 SPH21_RS22305 c1e5a552552c3b109d71f9c6d01f352e 154 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term 121 153 8.3E-6 T 21-04-2016 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SPH21_RS22305 c1e5a552552c3b109d71f9c6d01f352e 154 Gene3D G3DSA:3.10.50.30 121 153 2.1E-4 T 21-04-2016 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SPH21_RS22305 c1e5a552552c3b109d71f9c6d01f352e 154 SUPERFAMILY SSF54534 88 151 4.97E-5 T 21-04-2016 SPH21_RS09925 de366673af98f0975ae6cfa6b777bd14 268 TIGRFAM TIGR03513 GldL_gliding: gliding motility-associated protein GldL 12 263 5.2E-65 T 21-04-2016 IPR019852 Gliding motility-associated protein, GldL SPH21_RS10685 30ab24d6c63c7882e846ebdc56224021 225 Pfam PF04239 Protein of unknown function (DUF421) 109 174 2.4E-11 T 21-04-2016 IPR007353 Protein of unknown function DUF421 SPH21_RS10685 30ab24d6c63c7882e846ebdc56224021 225 Gene3D G3DSA:3.30.240.20 99 171 5.6E-16 T 21-04-2016 IPR023090 Uncharacterised domain UPF0702, alpha/beta domain SPH21_RS10685 30ab24d6c63c7882e846ebdc56224021 225 PANTHER PTHR34582:SF6 10 174 9.2E-37 T 21-04-2016 SPH21_RS10685 30ab24d6c63c7882e846ebdc56224021 225 PANTHER PTHR34582 10 174 9.2E-37 T 21-04-2016 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 PANTHER PTHR10342 28 274 2.4E-191 T 21-04-2016 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 PANTHER PTHR10342 307 362 2.4E-191 T 21-04-2016 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 PANTHER PTHR10342 416 610 2.4E-191 T 21-04-2016 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 ProSitePatterns PS00523 Sulfatases signature 1. 100 112 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 Pfam PF00884 Sulfatase 56 472 1.3E-77 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 SUPERFAMILY SSF53649 56 589 6.98E-127 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 PANTHER PTHR10342:SF201 28 274 2.4E-191 T 21-04-2016 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 PANTHER PTHR10342:SF201 307 362 2.4E-191 T 21-04-2016 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 PANTHER PTHR10342:SF201 416 610 2.4E-191 T 21-04-2016 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 Gene3D G3DSA:3.40.720.10 54 500 9.5E-106 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS01925 bb99078bf49a48300e85de56a0c50a80 610 Gene3D G3DSA:3.30.1120.10 502 593 2.3E-20 T 21-04-2016 SPH21_RS16340 5e69e6450836acc5d69c90304b579daf 216 SMART SM00382 26 214 1.0E-11 T 21-04-2016 IPR003593 AAA+ ATPase domain SPH21_RS16340 5e69e6450836acc5d69c90304b579daf 216 Gene3D G3DSA:3.40.50.300 1 216 3.2E-65 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16340 5e69e6450836acc5d69c90304b579daf 216 PANTHER PTHR24220 3 215 2.7E-101 T 21-04-2016 SPH21_RS16340 5e69e6450836acc5d69c90304b579daf 216 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 21-04-2016 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SPH21_RS16340 5e69e6450836acc5d69c90304b579daf 216 SUPERFAMILY SSF52540 1 216 4.13E-65 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16340 5e69e6450836acc5d69c90304b579daf 216 PANTHER PTHR24220:SF111 3 215 2.7E-101 T 21-04-2016 SPH21_RS16340 5e69e6450836acc5d69c90304b579daf 216 Pfam PF00005 ABC transporter 17 165 6.7E-32 T 21-04-2016 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SPH21_RS01015 9b4bc46752b53bcbecf7bee1a9561ff7 176 Gene3D G3DSA:1.20.120.450 3 174 2.6E-62 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS01015 9b4bc46752b53bcbecf7bee1a9561ff7 176 SUPERFAMILY SSF109854 5 171 6.26E-47 T 21-04-2016 SPH21_RS01015 9b4bc46752b53bcbecf7bee1a9561ff7 176 Hamap MF_01256 Putative metal-dependent hydrolase . 3 176 36.644 T 21-04-2016 IPR023774 Putative metal-dependent hydrolase YfiT SPH21_RS01015 9b4bc46752b53bcbecf7bee1a9561ff7 176 Pfam PF12867 DinB superfamily 34 167 7.5E-17 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS18855 662219f470a8a5666ace87078ee9ad16 324 SUPERFAMILY SSF56059 126 316 5.21E-22 T 21-04-2016 SPH21_RS18855 662219f470a8a5666ace87078ee9ad16 324 Gene3D G3DSA:3.30.470.20 196 297 9.1E-7 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS20060 196874a13e918fce977873e2f761de0d 152 SUPERFAMILY SSF54593 2 150 1.13E-37 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS20060 196874a13e918fce977873e2f761de0d 152 PANTHER PTHR33990:SF2 2 152 3.5E-60 T 21-04-2016 SPH21_RS20060 196874a13e918fce977873e2f761de0d 152 Pfam PF06983 3-demethylubiquinone-9 3-methyltransferase 2 111 1.7E-38 T 21-04-2016 IPR028973 3-demethylubiquinone-9 3-methyltransferase SPH21_RS20060 196874a13e918fce977873e2f761de0d 152 PANTHER PTHR33990 2 152 3.5E-60 T 21-04-2016 SPH21_RS20060 196874a13e918fce977873e2f761de0d 152 Gene3D G3DSA:3.10.180.10 2 124 9.0E-40 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS20060 196874a13e918fce977873e2f761de0d 152 PIRSF PIRSF021700 1 152 1.1E-51 T 21-04-2016 IPR009725 Predicted 3-demethylubiquinone-9 3-methyltransferase SPH21_RS04075 9411dcd0396cc709050f41d8be1cb1b7 251 SMART SM00342 157 235 0.0026 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04075 9411dcd0396cc709050f41d8be1cb1b7 251 Pfam PF12833 Helix-turn-helix domain 164 236 5.4E-8 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04075 9411dcd0396cc709050f41d8be1cb1b7 251 Gene3D G3DSA:1.10.10.60 139 195 2.6E-7 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18435 e4bd06e003206d755ad92bbf333f4851 345 SUPERFAMILY SSF81345 2 338 1.03E-80 T 21-04-2016 IPR029022 ABC transporter, BtuC-like SPH21_RS18435 e4bd06e003206d755ad92bbf333f4851 345 PANTHER PTHR30472:SF3 1 344 5.9E-128 T 21-04-2016 SPH21_RS18435 e4bd06e003206d755ad92bbf333f4851 345 PANTHER PTHR30472 1 344 5.9E-128 T 21-04-2016 IPR000522 ABC transporter, permease protein GO:0005215|GO:0016020 SPH21_RS18435 e4bd06e003206d755ad92bbf333f4851 345 Gene3D G3DSA:1.10.3470.10 2 342 1.9E-103 T 21-04-2016 IPR029022 ABC transporter, BtuC-like SPH21_RS18435 e4bd06e003206d755ad92bbf333f4851 345 Pfam PF01032 FecCD transport family 14 338 7.3E-90 T 21-04-2016 IPR000522 ABC transporter, permease protein GO:0005215|GO:0016020 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 Pfam PF03544 Gram-negative bacterial TonB protein C-terminal 196 269 6.8E-17 T 21-04-2016 IPR006260 TonB, C-terminal GO:0006810 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 PANTHER PTHR33446 54 275 9.0E-23 T 21-04-2016 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 Gene3D G3DSA:3.30.1150.10 192 230 4.8E-4 T 21-04-2016 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 PRINTS PR01374 Gram-negative bacterial tonB protein signature 211 229 4.2E-6 T 21-04-2016 IPR003538 Gram-negative bacterial TonB protein GO:0015343|GO:0015891|GO:0030288|GO:0031992 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 PRINTS PR01374 Gram-negative bacterial tonB protein signature 190 211 4.2E-6 T 21-04-2016 IPR003538 Gram-negative bacterial TonB protein GO:0015343|GO:0015891|GO:0030288|GO:0031992 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 PRINTS PR01374 Gram-negative bacterial tonB protein signature 88 98 4.2E-6 T 21-04-2016 IPR003538 Gram-negative bacterial TonB protein GO:0015343|GO:0015891|GO:0030288|GO:0031992 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 PANTHER PTHR33446:SF2 54 275 9.0E-23 T 21-04-2016 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 TIGRFAM TIGR01352 tonB_Cterm: TonB family C-terminal domain 197 262 6.1E-8 T 21-04-2016 IPR006260 TonB, C-terminal GO:0006810 SPH21_RS07835 4cc95b3a497e7ceaa33cd37acc3f6cb4 275 SUPERFAMILY SSF74653 190 269 1.44E-18 T 21-04-2016 SPH21_RS21625 31dc4e32f3b1f75062cd35d691c8cba7 340 PANTHER PTHR12286:SF4 1 179 2.3E-34 T 21-04-2016 SPH21_RS21625 31dc4e32f3b1f75062cd35d691c8cba7 340 PANTHER PTHR12286 1 179 2.3E-34 T 21-04-2016 SPH21_RS21625 31dc4e32f3b1f75062cd35d691c8cba7 340 SUPERFAMILY SSF51735 5 140 1.65E-17 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21625 31dc4e32f3b1f75062cd35d691c8cba7 340 Gene3D G3DSA:3.40.50.720 6 142 1.6E-18 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21625 31dc4e32f3b1f75062cd35d691c8cba7 340 Pfam PF03435 Saccharopine dehydrogenase NADP binding domain 9 124 4.7E-14 T 21-04-2016 IPR005097 Saccharopine dehydrogenase, NADP binding domain GO:0016491|GO:0055114 SPH21_RS07440 b3205bc95156a8e9a368a510397d5179 260 SUPERFAMILY SSF51366 11 257 3.41E-79 T 21-04-2016 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SPH21_RS07440 b3205bc95156a8e9a368a510397d5179 260 PANTHER PTHR22854 1 260 9.5E-93 T 21-04-2016 SPH21_RS07440 b3205bc95156a8e9a368a510397d5179 260 Pfam PF00218 Indole-3-glycerol phosphate synthase 4 255 1.0E-83 T 21-04-2016 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48|UniPathway: UPA00035 SPH21_RS07440 b3205bc95156a8e9a368a510397d5179 260 Hamap MF_00134_B Indole-3-glycerol phosphate synthase [trpC]. 2 258 31.366 T 21-04-2016 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48|UniPathway: UPA00035 SPH21_RS07440 b3205bc95156a8e9a368a510397d5179 260 PANTHER PTHR22854:SF2 1 260 9.5E-93 T 21-04-2016 SPH21_RS07440 b3205bc95156a8e9a368a510397d5179 260 Gene3D G3DSA:3.20.20.70 1 258 4.4E-92 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS07440 b3205bc95156a8e9a368a510397d5179 260 ProSitePatterns PS00614 Indole-3-glycerol phosphate synthase signature. 52 70 - T 21-04-2016 IPR001468 Indole-3-glycerol phosphate synthase, conserved site GO:0004425|GO:0006568 KEGG: 00400+4.1.1.48|UniPathway: UPA00035 SPH21_RS01460 697d7398a2c2ab1edb1aae3c5f645fdb 126 Pfam PF13564 DoxX-like family 13 106 5.6E-17 T 21-04-2016 IPR032808 DoxX family SPH21_RS18585 718c7df93d87bc9b7f18b08309b99105 351 Pfam PF01594 Domain of unknown function DUF20 27 338 2.2E-46 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS18585 718c7df93d87bc9b7f18b08309b99105 351 PANTHER PTHR21716:SF7 21 341 2.4E-65 T 21-04-2016 SPH21_RS18585 718c7df93d87bc9b7f18b08309b99105 351 PANTHER PTHR21716 21 341 2.4E-65 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS07700 e64af8e17e26bf6dadd22dfa9773ec14 353 Pfam PF02628 Cytochrome oxidase assembly protein 17 66 7.1E-12 T 21-04-2016 IPR003780 COX15/CtaA family GO:0006784|GO:0016021|GO:0016627|GO:0055114 UniPathway: UPA00269 SPH21_RS07700 e64af8e17e26bf6dadd22dfa9773ec14 353 Pfam PF02628 Cytochrome oxidase assembly protein 106 336 1.8E-27 T 21-04-2016 IPR003780 COX15/CtaA family GO:0006784|GO:0016021|GO:0016627|GO:0055114 UniPathway: UPA00269 SPH21_RS07700 e64af8e17e26bf6dadd22dfa9773ec14 353 PANTHER PTHR35457:SF1 103 344 2.6E-31 T 21-04-2016 SPH21_RS07700 e64af8e17e26bf6dadd22dfa9773ec14 353 PANTHER PTHR35457:SF1 4 52 2.6E-31 T 21-04-2016 SPH21_RS07700 e64af8e17e26bf6dadd22dfa9773ec14 353 PANTHER PTHR35457 103 344 2.6E-31 T 21-04-2016 SPH21_RS07700 e64af8e17e26bf6dadd22dfa9773ec14 353 PANTHER PTHR35457 4 52 2.6E-31 T 21-04-2016 SPH21_RS21410 8e2f6e858ca6f54c107b33ae7ea5395d 144 SUPERFAMILY SSF54427 30 140 9.35E-6 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS21410 8e2f6e858ca6f54c107b33ae7ea5395d 144 Pfam PF12893 Putative lumazine-binding 31 136 2.9E-7 T 21-04-2016 SPH21_RS21410 8e2f6e858ca6f54c107b33ae7ea5395d 144 Gene3D G3DSA:3.10.450.50 25 137 1.1E-11 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS17275 db8034b56fa5f30d9e8dfb146f747181 167 SUPERFAMILY SSF54001 77 165 1.08E-8 T 21-04-2016 SPH21_RS17275 db8034b56fa5f30d9e8dfb146f747181 167 Gene3D G3DSA:3.90.1720.10 59 144 9.8E-6 T 21-04-2016 IPR000064 Endopeptidase, NLPC/P60 domain KEGG: 00261+3.4.-.-|KEGG: 00310+3.4.-.-|KEGG: 00550+3.4.-.-|KEGG: 00780+3.4.-.- SPH21_RS17275 db8034b56fa5f30d9e8dfb146f747181 167 Pfam PF05257 CHAP domain 54 137 2.4E-14 T 21-04-2016 IPR007921 CHAP domain SPH21_RS23865 0821ec69fe20d724aa0ecc34d2206304 149 Gene3D G3DSA:3.10.450.40 6 140 1.8E-18 T 21-04-2016 SPH21_RS23865 0821ec69fe20d724aa0ecc34d2206304 149 Pfam PF04965 Gene 25-like lysozyme 29 127 3.3E-13 T 21-04-2016 IPR007048 GpW/Gp25/anti-adapter protein IraD SPH21_RS23865 0821ec69fe20d724aa0ecc34d2206304 149 SUPERFAMILY SSF160719 21 140 1.27E-16 T 21-04-2016 SPH21_RS09085 6c3d43a5b6c51119115d4d7e409089cb 259 Pfam PF05721 Phytanoyl-CoA dioxygenase (PhyH) 77 221 2.0E-5 T 21-04-2016 IPR008775 Phytanoyl-CoA dioxygenase SPH21_RS09085 6c3d43a5b6c51119115d4d7e409089cb 259 Gene3D G3DSA:2.60.120.620 5 219 5.5E-14 T 21-04-2016 SPH21_RS09085 6c3d43a5b6c51119115d4d7e409089cb 259 SUPERFAMILY SSF51197 1 219 1.65E-26 T 21-04-2016 SPH21_RS12425 d768fc946a522350dc16ee986b4deab7 304 PANTHER PTHR19325 126 282 2.6E-12 T 21-04-2016 SPH21_RS12425 d768fc946a522350dc16ee986b4deab7 304 PANTHER PTHR19325:SF359 126 282 2.6E-12 T 21-04-2016 SPH21_RS12425 d768fc946a522350dc16ee986b4deab7 304 SUPERFAMILY SSF55486 145 283 5.57E-15 T 21-04-2016 SPH21_RS12425 d768fc946a522350dc16ee986b4deab7 304 Gene3D G3DSA:3.40.390.10 159 236 2.3E-8 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS12425 d768fc946a522350dc16ee986b4deab7 304 Pfam PF05572 Pregnancy-associated plasma protein-A 143 286 9.9E-19 T 21-04-2016 IPR008754 Peptidase M43, pregnancy-associated plasma-A Reactome: REACT_15380 SPH21_RS08355 99ff6dc9c3b7ecbf1b9ed410df410364 389 SUPERFAMILY SSF55729 302 373 3.03E-15 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS08355 99ff6dc9c3b7ecbf1b9ed410df410364 389 SUPERFAMILY SSF55729 1 112 3.03E-15 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS08355 99ff6dc9c3b7ecbf1b9ed410df410364 389 SUPERFAMILY SSF55729 140 274 3.03E-15 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS08355 99ff6dc9c3b7ecbf1b9ed410df410364 389 PANTHER PTHR41368 1 378 8.8E-67 T 21-04-2016 SPH21_RS08355 99ff6dc9c3b7ecbf1b9ed410df410364 389 Gene3D G3DSA:3.40.630.30 194 370 9.1E-5 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS07680 92cfbcd0b98a979692486c4ec7af4709 201 Gene3D G3DSA:1.10.760.10 98 200 3.9E-17 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS07680 92cfbcd0b98a979692486c4ec7af4709 201 SUPERFAMILY SSF46626 88 198 3.95E-16 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS07680 92cfbcd0b98a979692486c4ec7af4709 201 SUPERFAMILY SSF46626 14 31 3.95E-16 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS07680 92cfbcd0b98a979692486c4ec7af4709 201 PANTHER PTHR40394 40 199 1.0E-24 T 21-04-2016 SPH21_RS07680 92cfbcd0b98a979692486c4ec7af4709 201 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III 108 195 1.2E-11 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS14425 6a1be2ef21ff4f62e929825fea1b991b 226 SUPERFAMILY SSF52266 32 221 2.14E-45 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS14425 6a1be2ef21ff4f62e929825fea1b991b 226 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 54 215 1.1E-26 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS14425 6a1be2ef21ff4f62e929825fea1b991b 226 PANTHER PTHR30383 52 220 1.0E-16 T 21-04-2016 SPH21_RS14425 6a1be2ef21ff4f62e929825fea1b991b 226 Gene3D G3DSA:3.40.50.1110 42 221 1.5E-46 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS21780 509db18367f74b6b43ded50fab1904ed 198 SUPERFAMILY SSF51206 21 125 7.33E-20 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS21780 509db18367f74b6b43ded50fab1904ed 198 Pfam PF00027 Cyclic nucleotide-binding domain 37 123 5.6E-14 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS21780 509db18367f74b6b43ded50fab1904ed 198 PANTHER PTHR24567 1 196 1.4E-37 T 21-04-2016 SPH21_RS21780 509db18367f74b6b43ded50fab1904ed 198 PANTHER PTHR24567:SF33 1 196 1.4E-37 T 21-04-2016 SPH21_RS21780 509db18367f74b6b43ded50fab1904ed 198 Gene3D G3DSA:2.60.120.10 11 162 8.1E-37 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PRINTS PR01021 OMPA domain signature 97 112 1.7E-10 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PRINTS PR01021 OMPA domain signature 66 88 1.7E-10 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PRINTS PR01021 OMPA domain signature 112 128 1.7E-10 T 21-04-2016 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 Pfam PF00691 OmpA family 65 161 2.0E-23 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PANTHER PTHR30128 44 168 4.8E-42 T 21-04-2016 SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 Gene3D G3DSA:3.30.1330.60 52 168 6.9E-41 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 SUPERFAMILY SSF103088 48 167 1.57E-36 T 21-04-2016 IPR006665 OmpA-like domain SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 130 149 1.2E-12 T 21-04-2016 SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 150 169 1.2E-12 T 21-04-2016 SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 112 129 1.2E-12 T 21-04-2016 SPH21_RS11640 0bd5f17d144eda6d535c0adeb966763f 169 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 83 109 1.2E-12 T 21-04-2016 SPH21_RS11620 ce1140dc1b038453ef6a7accab7cfb4d 630 Pfam PF07695 7TM diverse intracellular signalling 188 392 4.4E-38 T 21-04-2016 IPR011623 7TM-DISM receptor, extracellular domain, type 1 SPH21_RS11620 ce1140dc1b038453ef6a7accab7cfb4d 630 Pfam PF07696 7TMR-DISM extracellular 2 44 176 1.1E-23 T 21-04-2016 IPR011622 7TM-DISM receptor, extracellular domain, type 2 SPH21_RS16615 4ca9f44083f6f8ff19552894f44274e7 206 Pfam PF01300 Telomere recombination 21 198 2.4E-47 T 21-04-2016 IPR006070 YrdC-like domain GO:0003725 SPH21_RS16615 4ca9f44083f6f8ff19552894f44274e7 206 PANTHER PTHR17490 1 203 3.3E-79 T 21-04-2016 SPH21_RS16615 4ca9f44083f6f8ff19552894f44274e7 206 TIGRFAM TIGR00057 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family 5 200 4.7E-62 T 21-04-2016 IPR006070 YrdC-like domain GO:0003725 SPH21_RS16615 4ca9f44083f6f8ff19552894f44274e7 206 SUPERFAMILY SSF55821 3 204 2.41E-52 T 21-04-2016 IPR017945 DHBP synthase RibB-like alpha/beta domain SPH21_RS16615 4ca9f44083f6f8ff19552894f44274e7 206 Gene3D G3DSA:3.90.870.10 2 202 5.8E-60 T 21-04-2016 IPR017945 DHBP synthase RibB-like alpha/beta domain SPH21_RS16615 4ca9f44083f6f8ff19552894f44274e7 206 PANTHER PTHR17490:SF7 1 203 3.3E-79 T 21-04-2016 SPH21_RS24550 ba7782c0773db282c19cb88f8528a1e0 175 TIGRFAM TIGR01784 T_den_put_tspse: conserved hypothetical protein 20 173 4.9E-18 T 21-04-2016 IPR010106 Conserved hypothetical protein CHP01784 SPH21_RS24550 ba7782c0773db282c19cb88f8528a1e0 175 Pfam PF12784 PD-(D/E)XK nuclease family transposase 19 173 6.9E-47 T 21-04-2016 SPH21_RS24550 ba7782c0773db282c19cb88f8528a1e0 175 PANTHER PTHR41317 10 173 8.4E-29 T 21-04-2016 SPH21_RS24550 ba7782c0773db282c19cb88f8528a1e0 175 PANTHER PTHR41317:SF1 10 173 8.4E-29 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 PANTHER PTHR11532:SF57 490 549 2.7E-254 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 PANTHER PTHR11532:SF57 579 1080 2.7E-254 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 PANTHER PTHR11532:SF57 10 392 2.7E-254 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 PANTHER PTHR11532 490 549 2.7E-254 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 PANTHER PTHR11532 579 1080 2.7E-254 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 PANTHER PTHR11532 10 392 2.7E-254 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Gene3D G3DSA:2.170.130.10 120 234 5.3E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Gene3D G3DSA:2.60.40.1120 39 119 1.8E-8 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Pfam PF13715 CarboxypepD_reg-like domain 39 118 8.0E-18 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Pfam PF07715 TonB-dependent Receptor Plug Domain 127 233 8.2E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 38 1082 1.6E-262 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Gene3D G3DSA:2.40.170.20 235 253 3.1E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Gene3D G3DSA:2.40.170.20 895 935 3.1E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Gene3D G3DSA:2.40.170.20 334 792 3.1E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Gene3D G3DSA:2.40.170.20 828 829 3.1E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 Gene3D G3DSA:2.40.170.20 997 1082 3.1E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 SUPERFAMILY SSF49464 38 116 1.19E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 209 239 5.9E-20 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 SUPERFAMILY SSF56935 451 792 1.87E-88 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 SUPERFAMILY SSF56935 990 1082 1.87E-88 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 SUPERFAMILY SSF56935 886 930 1.87E-88 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 SUPERFAMILY SSF56935 114 257 1.87E-88 T 21-04-2016 SPH21_RS02375 a085a42d7faa93169253549886eb57ec 1082 SUPERFAMILY SSF56935 325 413 1.87E-88 T 21-04-2016 SPH21_RS19985 f1efa12c6f85d608bea94e5baf91adbb 289 PANTHER PTHR11122 193 289 6.6E-43 T 21-04-2016 SPH21_RS19985 f1efa12c6f85d608bea94e5baf91adbb 289 PANTHER PTHR11122 1 163 6.6E-43 T 21-04-2016 SPH21_RS19985 f1efa12c6f85d608bea94e5baf91adbb 289 Pfam PF01263 Aldose 1-epimerase 2 252 9.6E-23 T 21-04-2016 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 SPH21_RS19985 f1efa12c6f85d608bea94e5baf91adbb 289 Gene3D G3DSA:2.70.98.10 1 287 5.1E-20 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS19985 f1efa12c6f85d608bea94e5baf91adbb 289 PANTHER PTHR11122:SF14 193 289 6.6E-43 T 21-04-2016 SPH21_RS19985 f1efa12c6f85d608bea94e5baf91adbb 289 PANTHER PTHR11122:SF14 1 163 6.6E-43 T 21-04-2016 SPH21_RS19985 f1efa12c6f85d608bea94e5baf91adbb 289 SUPERFAMILY SSF74650 1 288 6.91E-50 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS21240 25746950618f1a6ca80ed1f7b98875f6 541 Pfam PF07980 SusD family 274 541 3.4E-26 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS21240 25746950618f1a6ca80ed1f7b98875f6 541 Pfam PF14322 Starch-binding associating with outer membrane 92 228 1.9E-25 T 21-04-2016 SPH21_RS21240 25746950618f1a6ca80ed1f7b98875f6 541 SUPERFAMILY SSF48452 22 441 2.61E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21240 25746950618f1a6ca80ed1f7b98875f6 541 SUPERFAMILY SSF48452 472 541 2.61E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21240 25746950618f1a6ca80ed1f7b98875f6 541 Gene3D G3DSA:1.25.40.10 377 488 5.2E-41 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21240 25746950618f1a6ca80ed1f7b98875f6 541 Gene3D G3DSA:1.25.40.10 210 325 5.2E-41 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11505 82bad9de1c285b11c69c0bd540ae506e 237 Pfam PF05336 Domain of unknown function (DUF718) 139 233 3.9E-9 T 21-04-2016 IPR008000 Rhamnose/fucose mutarotase GO:0005737|GO:0016857 UniPathway: UPA00125 SPH21_RS11505 82bad9de1c285b11c69c0bd540ae506e 237 SUPERFAMILY SSF54909 142 233 1.39E-6 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS00500 e6d10b1b38be3e9b610f300179046bee 152 Pfam PF03713 Domain of unknown function (DUF305) 95 149 8.9E-12 T 21-04-2016 IPR005183 Domain of unknown function DUF305 SPH21_RS00500 e6d10b1b38be3e9b610f300179046bee 152 Gene3D G3DSA:1.20.1260.10 49 147 1.3E-19 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 PIRSF PIRSF000303 1 161 1.8E-55 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 PRINTS PR01011 Glutathione peroxidase family signature 123 132 6.8E-14 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 PRINTS PR01011 Glutathione peroxidase family signature 57 73 6.8E-14 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 PRINTS PR01011 Glutathione peroxidase family signature 22 39 6.8E-14 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 PANTHER PTHR11592 4 161 2.6E-54 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 Gene3D G3DSA:3.40.30.10 4 161 2.2E-50 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 Pfam PF00255 Glutathione peroxidase 4 110 5.9E-33 T 21-04-2016 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 ProSitePatterns PS00460 Glutathione peroxidases active site. 24 39 - T 21-04-2016 IPR029759 Glutathione peroxidase active site SPH21_RS14920 4ced6848aa0033d233102db5ccb14a29 161 SUPERFAMILY SSF52833 4 161 1.11E-44 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS11410 b1181d78d09a190ab2dcea667bf3017f 921 Pfam PF05592 Bacterial alpha-L-rhamnosidase 359 872 1.1E-179 T 21-04-2016 IPR008902 Bacterial alpha-L-rhamnosidase SPH21_RS11410 b1181d78d09a190ab2dcea667bf3017f 921 Gene3D G3DSA:2.60.120.260 350 459 3.5E-16 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS11410 b1181d78d09a190ab2dcea667bf3017f 921 PIRSF PIRSF010631 1 921 0.0 T 21-04-2016 IPR016007 Alpha-L-rhamnosidase SPH21_RS11410 b1181d78d09a190ab2dcea667bf3017f 921 SUPERFAMILY SSF48208 460 880 1.53E-45 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS11410 b1181d78d09a190ab2dcea667bf3017f 921 PANTHER PTHR33307 2 883 4.7E-290 T 21-04-2016 SPH21_RS11410 b1181d78d09a190ab2dcea667bf3017f 921 PANTHER PTHR33307:SF5 2 883 4.7E-290 T 21-04-2016 SPH21_RS11410 b1181d78d09a190ab2dcea667bf3017f 921 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 177 349 2.1E-55 T 21-04-2016 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SPH21_RS07255 ef340efe336e95d44ed7b168997516db 278 SUPERFAMILY SSF54427 175 275 7.68E-8 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS07255 ef340efe336e95d44ed7b168997516db 278 Gene3D G3DSA:3.10.450.50 180 270 1.5E-4 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS09465 bfbd21583f3374d6c4bbb1dd3787095e 381 Gene3D G3DSA:3.40.640.10 5 242 3.2E-66 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS09465 bfbd21583f3374d6c4bbb1dd3787095e 381 Gene3D G3DSA:3.90.1150.10 243 378 1.2E-48 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS09465 bfbd21583f3374d6c4bbb1dd3787095e 381 SUPERFAMILY SSF53383 39 377 1.46E-99 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS09465 bfbd21583f3374d6c4bbb1dd3787095e 381 PANTHER PTHR11808 6 380 3.6E-151 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS09465 bfbd21583f3374d6c4bbb1dd3787095e 381 ProSitePatterns PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 185 199 - T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS09465 bfbd21583f3374d6c4bbb1dd3787095e 381 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 6 375 5.2E-117 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS09465 bfbd21583f3374d6c4bbb1dd3787095e 381 PIRSF PIRSF001434 1 379 6.4E-125 T 21-04-2016 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 SPH21_RS18685 7d703ce54dc0bbc93de3115a87bb10d6 433 Pfam PF07690 Major Facilitator Superfamily 29 382 7.4E-29 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS18685 7d703ce54dc0bbc93de3115a87bb10d6 433 SUPERFAMILY SSF103473 14 415 1.96E-56 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS18685 7d703ce54dc0bbc93de3115a87bb10d6 433 Gene3D G3DSA:1.20.1250.20 228 417 6.5E-16 T 21-04-2016 SPH21_RS18685 7d703ce54dc0bbc93de3115a87bb10d6 433 Gene3D G3DSA:1.20.1250.20 23 215 1.5E-25 T 21-04-2016 SPH21_RS18685 7d703ce54dc0bbc93de3115a87bb10d6 433 PANTHER PTHR23515 10 433 4.5E-132 T 21-04-2016 SPH21_RS18685 7d703ce54dc0bbc93de3115a87bb10d6 433 PANTHER PTHR23515:SF2 10 433 4.5E-132 T 21-04-2016 SPH21_RS21590 bd8c99bd73745f7349b6551241f7aad3 149 Gene3D G3DSA:3.10.450.50 17 141 6.2E-19 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS21590 bd8c99bd73745f7349b6551241f7aad3 149 SUPERFAMILY SSF54427 19 140 1.79E-21 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS13335 b73a2c624d00e27fb0d2c02bf32a683b 314 Pfam PF01066 CDP-alcohol phosphatidyltransferase 52 116 1.4E-12 T 21-04-2016 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SPH21_RS20240 3d64a72f1c927f3576e0abc20edd34dd 280 Pfam PF14257 Domain of unknown function (DUF4349) 39 261 2.1E-63 T 21-04-2016 IPR025645 Domain of unknown function DUF4349 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 Gene3D G3DSA:1.10.10.60 213 246 8.4E-6 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 Gene3D G3DSA:1.10.10.60 252 295 2.1E-14 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 278 294 8.0E-7 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 263 278 8.0E-7 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 SMART SM00342 211 294 1.9E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 PANTHER PTHR11019:SF50 1 294 2.5E-55 T 21-04-2016 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 Pfam PF12833 Helix-turn-helix domain 218 294 1.8E-18 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 PANTHER PTHR11019 1 294 2.5E-55 T 21-04-2016 SPH21_RS00635 b206a28e97aa1345d36fda053aa28a5c 297 SUPERFAMILY SSF46689 250 295 1.93E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 203 233 4.7E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 30 1103 3.0E-250 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 PANTHER PTHR11532 4 384 1.6E-247 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 PANTHER PTHR11532 497 1101 1.6E-247 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Gene3D G3DSA:2.40.170.20 229 247 5.4E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Gene3D G3DSA:2.40.170.20 897 942 5.4E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Gene3D G3DSA:2.40.170.20 455 822 5.4E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Gene3D G3DSA:2.40.170.20 1014 1101 5.4E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Gene3D G3DSA:2.40.170.20 335 419 5.4E-42 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 PANTHER PTHR11532:SF57 4 384 1.6E-247 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 PANTHER PTHR11532:SF57 497 1101 1.6E-247 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Pfam PF07715 TonB-dependent Receptor Plug Domain 120 227 3.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Pfam PF13715 CarboxypepD_reg-like domain 32 112 1.1E-15 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Gene3D G3DSA:2.60.40.1120 31 115 1.4E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 Gene3D G3DSA:2.170.130.10 116 228 3.8E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 SUPERFAMILY SSF56935 460 809 4.21E-85 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 SUPERFAMILY SSF56935 326 418 4.21E-85 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 SUPERFAMILY SSF56935 888 932 4.21E-85 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 SUPERFAMILY SSF56935 1004 1101 4.21E-85 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 SUPERFAMILY SSF56935 109 251 4.21E-85 T 21-04-2016 SPH21_RS23410 a1420516c9fe5e2c60018a60c2685061 1103 SUPERFAMILY SSF49464 30 110 2.22E-15 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS18740 ee472994d5ee440b47246baaab7a229e 179 Gene3D G3DSA:2.30.110.10 19 178 1.6E-45 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS18740 ee472994d5ee440b47246baaab7a229e 179 SUPERFAMILY SSF50475 22 151 1.76E-30 T 21-04-2016 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 UniPathway: UPA00647 SPH21_RS18740 ee472994d5ee440b47246baaab7a229e 179 PANTHER PTHR34818 9 148 2.0E-35 T 21-04-2016 SPH21_RS18740 ee472994d5ee440b47246baaab7a229e 179 Pfam PF16242 Pyridoxamine 5'-phosphate oxidase like 20 170 1.7E-47 T 21-04-2016 SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 Pfam PF00083 Sugar (and other) transporter 223 422 1.6E-11 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 Pfam PF00083 Sugar (and other) transporter 17 215 4.2E-31 T 21-04-2016 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 SUPERFAMILY SSF103473 7 416 1.7E-65 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 PANTHER PTHR23508:SF4 2 427 9.5E-226 T 21-04-2016 SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 PANTHER PTHR23508 2 427 9.5E-226 T 21-04-2016 SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 Gene3D G3DSA:1.20.1250.20 11 218 1.6E-26 T 21-04-2016 SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 Gene3D G3DSA:1.20.1250.20 235 424 5.0E-19 T 21-04-2016 SPH21_RS11805 b622f96727907b32a782286d757bdba5 430 ProSitePatterns PS00217 Sugar transport proteins signature 2. 122 147 - T 21-04-2016 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SPH21_RS08205 6018e93f0f8e3803b9412221f40c5bd1 289 SUPERFAMILY SSF51658 28 283 5.67E-36 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS08205 6018e93f0f8e3803b9412221f40c5bd1 289 Pfam PF01261 Xylose isomerase-like TIM barrel 138 223 8.3E-11 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS08205 6018e93f0f8e3803b9412221f40c5bd1 289 Gene3D G3DSA:3.20.20.150 33 285 1.5E-41 T 21-04-2016 IPR013022 Xylose isomerase-like, TIM barrel domain SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 ProSitePatterns PS00438 Catalase proximal active site signature. 44 60 - T 21-04-2016 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 Pfam PF00199 Catalase 10 389 3.1E-184 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 Pfam PF06628 Catalase-related immune-responsive 419 484 2.4E-17 T 21-04-2016 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PIRSF PIRSF038928 2 488 1.6E-204 T 21-04-2016 IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PANTHER PTHR11465 11 489 3.4E-272 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 Gene3D G3DSA:2.40.180.10 7 357 8.2E-171 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PRINTS PR00067 Catalase signature 21 44 7.2E-69 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PRINTS PR00067 Catalase signature 321 347 7.2E-69 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PRINTS PR00067 Catalase signature 289 316 7.2E-69 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PRINTS PR00067 Catalase signature 124 142 7.2E-69 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PRINTS PR00067 Catalase signature 105 122 7.2E-69 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 PRINTS PR00067 Catalase signature 84 102 7.2E-69 T 21-04-2016 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 SMART SM01060 8 392 2.7E-259 T 21-04-2016 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS24100 668b2b236702e254a231e681c9f491f6 510 SUPERFAMILY SSF56634 7 498 4.97E-198 T 21-04-2016 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SPH21_RS07925 980562517fe40ccb46a9f7037fcf4c95 221 PANTHER PTHR30353 3 218 2.9E-62 T 21-04-2016 IPR032818 DedA family SPH21_RS07925 980562517fe40ccb46a9f7037fcf4c95 221 PANTHER PTHR30353:SF0 3 218 2.9E-62 T 21-04-2016 SPH21_RS07925 980562517fe40ccb46a9f7037fcf4c95 221 Pfam PF09335 SNARE associated Golgi protein 42 168 5.3E-17 T 21-04-2016 IPR032816 SNARE associated Golgi protein SPH21_RS01890 c783dd6bd576ffcd6b0bb90ecb59b2cc 137 Pfam PF02566 OsmC-like protein 40 132 2.8E-19 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS01890 c783dd6bd576ffcd6b0bb90ecb59b2cc 137 PANTHER PTHR33797:SF1 1 137 4.8E-45 T 21-04-2016 SPH21_RS01890 c783dd6bd576ffcd6b0bb90ecb59b2cc 137 TIGRFAM TIGR03562 osmo_induc_OsmC: peroxiredoxin, OsmC subfamily 2 132 2.0E-49 T 21-04-2016 IPR019904 Peroxiredoxin OsmC GO:0004601|GO:0006979 KEGG: 00480+1.11.1.15 SPH21_RS01890 c783dd6bd576ffcd6b0bb90ecb59b2cc 137 PANTHER PTHR33797 1 137 4.8E-45 T 21-04-2016 SPH21_RS01890 c783dd6bd576ffcd6b0bb90ecb59b2cc 137 SUPERFAMILY SSF82784 2 136 9.42E-35 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS01890 c783dd6bd576ffcd6b0bb90ecb59b2cc 137 Gene3D G3DSA:3.30.300.20 1 134 2.5E-42 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS05125 490cef099effa820d7229e89c5522269 235 Gene3D G3DSA:3.40.1160.10 1 234 5.6E-90 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS05125 490cef099effa820d7229e89c5522269 235 Hamap MF_01220_B Uridylate kinase [pyrH]. 1 234 46.043 T 21-04-2016 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22|UniPathway: UPA00159 SPH21_RS05125 490cef099effa820d7229e89c5522269 235 TIGRFAM TIGR02075 pyrH_bact: UMP kinase 3 234 9.0E-105 T 21-04-2016 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22|UniPathway: UPA00159 SPH21_RS05125 490cef099effa820d7229e89c5522269 235 PIRSF PIRSF005650 1 235 7.9E-100 T 21-04-2016 IPR011817 Uridylate kinase GO:0006221|GO:0009041 KEGG: 00240+2.7.4.22|UniPathway: UPA00159 SPH21_RS05125 490cef099effa820d7229e89c5522269 235 SUPERFAMILY SSF53633 1 233 9.16E-76 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS05125 490cef099effa820d7229e89c5522269 235 PANTHER PTHR21499 1 233 5.9E-119 T 21-04-2016 SPH21_RS05125 490cef099effa820d7229e89c5522269 235 PANTHER PTHR21499:SF23 1 233 5.9E-119 T 21-04-2016 IPR011817 Uridylate kinase GO:0006221|GO:0009041 KEGG: 00240+2.7.4.22|UniPathway: UPA00159 SPH21_RS05125 490cef099effa820d7229e89c5522269 235 Pfam PF00696 Amino acid kinase family 4 213 2.4E-31 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS15400 ec2d885a98d04a4c48d4d9d6a154c9da 150 Pfam PF01475 Ferric uptake regulator family 16 115 3.1E-11 T 21-04-2016 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 SPH21_RS15400 ec2d885a98d04a4c48d4d9d6a154c9da 150 SUPERFAMILY SSF46785 9 139 1.76E-21 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS15400 ec2d885a98d04a4c48d4d9d6a154c9da 150 Gene3D G3DSA:1.10.10.10 7 84 1.4E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04195 e2e0e641872f1437c466be07dfacbaa5 342 PANTHER PTHR34220 11 342 2.7E-20 T 21-04-2016 SPH21_RS04195 e2e0e641872f1437c466be07dfacbaa5 342 Pfam PF06580 Histidine kinase 158 234 3.7E-15 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS24890 a5be8d26675d04a0bb538a6b45c5a82f 140 SUPERFAMILY SSF48452 15 84 1.99E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24890 a5be8d26675d04a0bb538a6b45c5a82f 140 Gene3D G3DSA:1.25.40.10 14 75 3.7E-8 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22095 4ead634a881a66febf2691c7f7cfa3f5 1036 Pfam PF13502 AsmA-like C-terminal region 793 975 2.1E-10 T 21-04-2016 IPR032712 AsmA-like, C-terminal SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 PANTHER PTHR10108 33 275 9.3E-93 T 21-04-2016 SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 PANTHER PTHR10108 291 363 9.3E-93 T 21-04-2016 SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 SUPERFAMILY SSF53335 104 359 9.71E-75 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 Pfam PF02353 Mycolic acid cyclopropane synthetase 94 354 2.8E-86 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 PIRSF PIRSF003085 14 365 5.8E-110 T 21-04-2016 IPR003333 Mycolic acid cyclopropane synthase GO:0008610 SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 Gene3D G3DSA:3.40.50.150 101 358 1.7E-89 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 PANTHER PTHR10108:SF795 33 275 9.3E-93 T 21-04-2016 SPH21_RS18365 602f9f4100fcd3966b61405a38b688f3 369 PANTHER PTHR10108:SF795 291 363 9.3E-93 T 21-04-2016 SPH21_RS13350 69b3e9c2326f3e39bcd1aa0c289ffe02 353 Pfam PF03595 Voltage-dependent anion channel 13 339 2.3E-42 T 21-04-2016 IPR004695 Voltage-dependent anion channel GO:0016021|GO:0055085 SPH21_RS13350 69b3e9c2326f3e39bcd1aa0c289ffe02 353 PANTHER PTHR31686 1 345 4.0E-14 T 21-04-2016 SPH21_RS20985 9059e66c9a7fdbe60249d872f0bc56de 64 SUPERFAMILY SSF53649 5 47 4.25E-7 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS20985 9059e66c9a7fdbe60249d872f0bc56de 64 Gene3D G3DSA:3.30.1120.10 4 51 1.4E-10 T 21-04-2016 SPH21_RS07535 8769950822bf16737fded20f6726e55c 395 Pfam PF01103 Surface antigen 104 395 1.2E-12 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 PANTHER PTHR11236:SF18 81 421 5.8E-111 T 21-04-2016 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 PANTHER PTHR11236 81 421 5.8E-111 T 21-04-2016 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 SUPERFAMILY SSF56322 38 424 1.44E-107 T 21-04-2016 IPR005801 ADC synthase GO:0009058 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 PRINTS PR00095 Anthranilate synthase component I signature 275 288 4.2E-15 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 PRINTS PR00095 Anthranilate synthase component I signature 261 274 4.2E-15 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 PRINTS PR00095 Anthranilate synthase component I signature 355 369 4.2E-15 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 PRINTS PR00095 Anthranilate synthase component I signature 370 384 4.2E-15 T 21-04-2016 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661|UniPathway: UPA00035 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 Gene3D G3DSA:3.60.120.10 51 424 1.3E-109 T 21-04-2016 IPR005801 ADC synthase GO:0009058 SPH21_RS14895 a65ad7fb36e0a24c2da69a07e2317bd4 427 Pfam PF00425 chorismate binding enzyme 158 415 5.1E-80 T 21-04-2016 IPR015890 Chorismate-utilising enzyme, C-terminal SPH21_RS09540 575cfc80279a8cfabd441cb30c81125c 544 SUPERFAMILY SSF75005 76 228 5.5E-6 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS22120 9b4bd9e133f33d92db08579f8d6645f9 257 Pfam PF00440 Bacterial regulatory proteins, tetR family 54 92 1.9E-8 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS22120 9b4bd9e133f33d92db08579f8d6645f9 257 Gene3D G3DSA:1.10.357.10 43 179 1.3E-15 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS22120 9b4bd9e133f33d92db08579f8d6645f9 257 SUPERFAMILY SSF46689 44 104 2.15E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS06545 53ca0eb9fc79f80efaaaa1948c862aff 119 SUPERFAMILY SSF51182 25 99 3.74E-5 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS06545 53ca0eb9fc79f80efaaaa1948c862aff 119 Gene3D G3DSA:2.60.120.10 23 83 5.3E-5 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS22880 589becf7cb54f16070a27b80d8a6a283 341 Gene3D G3DSA:3.30.565.10 201 288 9.5E-6 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS22880 589becf7cb54f16070a27b80d8a6a283 341 Pfam PF06580 Histidine kinase 150 228 4.1E-23 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS22880 589becf7cb54f16070a27b80d8a6a283 341 PANTHER PTHR34220 5 341 6.2E-58 T 21-04-2016 SPH21_RS22880 589becf7cb54f16070a27b80d8a6a283 341 PANTHER PTHR34220:SF1 5 341 6.2E-58 T 21-04-2016 SPH21_RS22880 589becf7cb54f16070a27b80d8a6a283 341 SUPERFAMILY SSF55874 207 317 6.32E-7 T 21-04-2016 IPR003594 Histidine kinase-like ATPase, C-terminal domain SPH21_RS22880 589becf7cb54f16070a27b80d8a6a283 341 Pfam PF14501 GHKL domain 254 338 1.6E-6 T 21-04-2016 IPR032834 Sensor histidine kinase NatK, C-terminal domain SPH21_RS12540 b89103139c1be08927d8e7473412e004 320 PANTHER PTHR30473:SF1 9 317 1.2E-134 T 21-04-2016 SPH21_RS12540 b89103139c1be08927d8e7473412e004 320 SUPERFAMILY SSF52540 22 67 1.31E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12540 b89103139c1be08927d8e7473412e004 320 SUPERFAMILY SSF52540 114 293 1.31E-43 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS12540 b89103139c1be08927d8e7473412e004 320 PANTHER PTHR30473 9 317 1.2E-134 T 21-04-2016 SPH21_RS12540 b89103139c1be08927d8e7473412e004 320 Pfam PF02562 PhoH-like protein 115 317 2.7E-92 T 21-04-2016 IPR003714 PhoH-like protein GO:0005524 SPH21_RS12540 b89103139c1be08927d8e7473412e004 320 Gene3D G3DSA:3.40.50.300 115 317 2.0E-86 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS13615 56b73345419db72cd07f50f7122aff4e 188 SUPERFAMILY SSF46689 5 76 7.48E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS13615 56b73345419db72cd07f50f7122aff4e 188 PANTHER PTHR30055 6 169 4.4E-14 T 21-04-2016 SPH21_RS13615 56b73345419db72cd07f50f7122aff4e 188 Gene3D G3DSA:1.10.357.10 8 175 4.4E-22 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS13615 56b73345419db72cd07f50f7122aff4e 188 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 55 6.3E-6 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS11440 7a690a26504feb53b067aeef477b3ad1 109 Pfam PF06296 RelE toxin of RelE / RelB toxin-antitoxin system 13 103 5.5E-8 T 21-04-2016 IPR009387 Toxin HigB-2 SPH21_RS10075 0acd7f83ed17b985ca0528b55be6b1be 132 Gene3D G3DSA:3.40.50.2300 6 130 3.0E-18 T 21-04-2016 SPH21_RS10075 0acd7f83ed17b985ca0528b55be6b1be 132 Pfam PF00072 Response regulator receiver domain 6 125 1.1E-11 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS10075 0acd7f83ed17b985ca0528b55be6b1be 132 SUPERFAMILY SSF52172 4 130 1.99E-15 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS10075 0acd7f83ed17b985ca0528b55be6b1be 132 SMART SM00448 3 127 5.5E-5 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS05415 24521bdd908d9c7bfb19628c8e3c0008 488 PANTHER PTHR35148 3 486 6.0E-54 T 21-04-2016 SPH21_RS05415 24521bdd908d9c7bfb19628c8e3c0008 488 SUPERFAMILY SSF48452 22 486 6.2E-124 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05415 24521bdd908d9c7bfb19628c8e3c0008 488 Pfam PF12771 Starch-binding associating with outer membrane 19 487 1.0E-56 T 21-04-2016 SPH21_RS07285 e538051bbcfd9d71244d37d6fb6f11f3 340 Pfam PF01212 Beta-eliminating lyase 4 289 4.2E-51 T 21-04-2016 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase GO:0006520|GO:0016829 SPH21_RS07285 e538051bbcfd9d71244d37d6fb6f11f3 340 Gene3D G3DSA:3.90.1150.10 252 338 5.5E-11 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS07285 e538051bbcfd9d71244d37d6fb6f11f3 340 PANTHER PTHR10289 1 338 5.5E-106 T 21-04-2016 SPH21_RS07285 e538051bbcfd9d71244d37d6fb6f11f3 340 Gene3D G3DSA:3.40.640.10 2 249 1.3E-56 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS07285 e538051bbcfd9d71244d37d6fb6f11f3 340 SUPERFAMILY SSF53383 1 338 8.93E-80 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS07285 e538051bbcfd9d71244d37d6fb6f11f3 340 PANTHER PTHR10289:SF8 1 338 5.5E-106 T 21-04-2016 SPH21_RS18670 10a48872882d1d9d55ef8cea218df8ee 239 SUPERFAMILY SSF53790 11 217 2.76E-13 T 21-04-2016 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 SPH21_RS18670 10a48872882d1d9d55ef8cea218df8ee 239 Gene3D G3DSA:3.40.1010.10 11 50 9.2E-4 T 21-04-2016 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 SPH21_RS16665 c00a00fcb6230d2cc6dc707a9d7de65d 144 SUPERFAMILY SSF46626 10 129 8.05E-18 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS16665 c00a00fcb6230d2cc6dc707a9d7de65d 144 Pfam PF00034 Cytochrome c 36 117 1.3E-9 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS16665 c00a00fcb6230d2cc6dc707a9d7de65d 144 Gene3D G3DSA:1.10.760.10 8 143 1.3E-22 T 21-04-2016 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 SPH21_RS20245 dcd534b3defc36fd8a9d46c008affebb 368 PANTHER PTHR30294 1 366 3.9E-92 T 21-04-2016 SPH21_RS20245 dcd534b3defc36fd8a9d46c008affebb 368 Pfam PF12698 ABC-2 family transporter protein 19 360 9.0E-42 T 21-04-2016 SPH21_RS20245 dcd534b3defc36fd8a9d46c008affebb 368 Gene3D G3DSA:3.40.1710.10 45 146 4.4E-4 T 21-04-2016 SPH21_RS20245 dcd534b3defc36fd8a9d46c008affebb 368 PANTHER PTHR30294:SF12 1 366 3.9E-92 T 21-04-2016 SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 SMART SM00929 100 140 1.2E-19 T 21-04-2016 IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding GO:0016491|GO:0055114 SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 SUPERFAMILY SSF54862 93 226 1.88E-33 T 21-04-2016 SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 PANTHER PTHR11615 8 266 1.3E-65 T 21-04-2016 SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 Gene3D G3DSA:3.10.20.30 6 69 8.1E-8 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 PANTHER PTHR11615:SF38 8 266 1.3E-65 T 21-04-2016 SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain 5 90 1.3E-15 T 21-04-2016 SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 SUPERFAMILY SSF54292 7 88 2.36E-15 T 21-04-2016 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SPH21_RS07885 a0c4b364ad2f32cf415ef5accb533ad2 336 Pfam PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 100 136 1.0E-16 T 21-04-2016 IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding GO:0016491|GO:0055114 SPH21_RS23980 8881e6b18056eb7683c84fb34df9d308 317 PANTHER PTHR10366:SF267 5 317 3.3E-111 T 21-04-2016 SPH21_RS23980 8881e6b18056eb7683c84fb34df9d308 317 PANTHER PTHR10366 5 317 3.3E-111 T 21-04-2016 SPH21_RS23980 8881e6b18056eb7683c84fb34df9d308 317 Gene3D G3DSA:3.40.50.720 5 312 1.3E-60 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS23980 8881e6b18056eb7683c84fb34df9d308 317 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 245 7.9E-22 T 21-04-2016 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SPH21_RS23980 8881e6b18056eb7683c84fb34df9d308 317 SUPERFAMILY SSF51735 1 315 1.11E-61 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21015 1341bcc431488937b2769a7e38ea1319 530 Pfam PF07980 SusD family 359 530 6.4E-27 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS21015 1341bcc431488937b2769a7e38ea1319 530 Pfam PF14322 Starch-binding associating with outer membrane 93 232 1.6E-18 T 21-04-2016 SPH21_RS21015 1341bcc431488937b2769a7e38ea1319 530 SUPERFAMILY SSF48452 17 530 4.05E-98 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21015 1341bcc431488937b2769a7e38ea1319 530 Gene3D G3DSA:1.25.40.10 213 462 1.8E-26 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10550 4fc553a3a356b18d3c93c032479fad48 151 Gene3D G3DSA:1.20.1260.10 8 132 0.001 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS10550 4fc553a3a356b18d3c93c032479fad48 151 Pfam PF09537 Domain of unknown function (DUF2383) 8 118 2.1E-27 T 21-04-2016 IPR019052 Domain of unknown function DUF2383 SPH21_RS10550 4fc553a3a356b18d3c93c032479fad48 151 TIGRFAM TIGR02284 TIGR02284: conserved hypothetical protein 9 147 4.2E-31 T 21-04-2016 IPR011971 Conserved hypothetical protein CHP02284 SPH21_RS10550 4fc553a3a356b18d3c93c032479fad48 151 PIRSF PIRSF029477 1 151 3.1E-34 T 21-04-2016 IPR016920 Uncharacterised conserved protein UCP029477 SPH21_RS09725 cefb57ff95f84a80c8e4ff2f6ff40186 345 Gene3D G3DSA:3.60.60.10 23 326 1.2E-105 T 21-04-2016 IPR003199 Choloylglycine hydrolase/Peptidase C59 family GO:0016811 SPH21_RS09725 cefb57ff95f84a80c8e4ff2f6ff40186 345 SUPERFAMILY SSF56235 23 326 1.16E-100 T 21-04-2016 IPR029055 Nucleophile aminohydrolases, N-terminal SPH21_RS09725 cefb57ff95f84a80c8e4ff2f6ff40186 345 PANTHER PTHR35527 1 345 5.4E-156 T 21-04-2016 SPH21_RS09725 cefb57ff95f84a80c8e4ff2f6ff40186 345 PANTHER PTHR35527:SF2 1 345 5.4E-156 T 21-04-2016 SPH21_RS09725 cefb57ff95f84a80c8e4ff2f6ff40186 345 Pfam PF02275 Linear amide C-N hydrolases, choloylglycine hydrolase family 23 308 2.6E-48 T 21-04-2016 IPR029132 Choloylglycine hydrolase/NAAA C-terminal SPH21_RS15475 bd0c19825b0325b7e7810db6fd72de16 245 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 60 74 - T 21-04-2016 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS15475 bd0c19825b0325b7e7810db6fd72de16 245 PANTHER PTHR11079:SF73 17 242 2.6E-49 T 21-04-2016 SPH21_RS15475 bd0c19825b0325b7e7810db6fd72de16 245 SUPERFAMILY SSF55120 17 241 1.14E-51 T 21-04-2016 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS15475 bd0c19825b0325b7e7810db6fd72de16 245 Pfam PF00849 RNA pseudouridylate synthase 23 166 1.3E-26 T 21-04-2016 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 SPH21_RS15475 bd0c19825b0325b7e7810db6fd72de16 245 PANTHER PTHR11079 17 242 2.6E-49 T 21-04-2016 SPH21_RS21745 b2174c5b445a30f7afcae7053b192db2 719 Gene3D G3DSA:3.20.20.80 104 276 3.8E-13 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS21745 b2174c5b445a30f7afcae7053b192db2 719 SUPERFAMILY SSF51445 103 341 1.67E-9 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS21745 b2174c5b445a30f7afcae7053b192db2 719 Pfam PF14871 Hypothetical glycosyl hydrolase 6 60 187 2.2E-31 T 21-04-2016 IPR028212 Hypothetical glycosyl hydrolase 6 SPH21_RS11400 1645b8ab9f3de7494b5cd2280ade7469 619 SUPERFAMILY SSF50939 263 399 1.18E-6 T 21-04-2016 IPR011040 Sialidases SPH21_RS11400 1645b8ab9f3de7494b5cd2280ade7469 619 SUPERFAMILY SSF50939 69 174 1.18E-6 T 21-04-2016 IPR011040 Sialidases SPH21_RS11400 1645b8ab9f3de7494b5cd2280ade7469 619 SUPERFAMILY SSF50939 201 220 1.18E-6 T 21-04-2016 IPR011040 Sialidases SPH21_RS11400 1645b8ab9f3de7494b5cd2280ade7469 619 Pfam PF13088 BNR repeat-like domain 281 354 8.4E-8 T 21-04-2016 IPR011040 Sialidases SPH21_RS21835 9345df43827aa3643d5a9d85a3dd18f3 393 PANTHER PTHR30273:SF2 192 391 1.8E-61 T 21-04-2016 SPH21_RS21835 9345df43827aa3643d5a9d85a3dd18f3 393 PANTHER PTHR30273:SF2 1 125 1.8E-61 T 21-04-2016 SPH21_RS21835 9345df43827aa3643d5a9d85a3dd18f3 393 PANTHER PTHR30273 192 391 1.8E-61 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21835 9345df43827aa3643d5a9d85a3dd18f3 393 PANTHER PTHR30273 1 125 1.8E-61 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS21835 9345df43827aa3643d5a9d85a3dd18f3 393 Pfam PF16344 Domain of unknown function (DUF4974) 291 390 6.6E-20 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS21835 9345df43827aa3643d5a9d85a3dd18f3 393 Pfam PF04773 FecR protein 190 283 1.3E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS00950 ee61a11612b0da08606851f6212ed954 544 Pfam PF07980 SusD family 391 544 4.0E-27 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS00950 ee61a11612b0da08606851f6212ed954 544 Pfam PF14322 Starch-binding associating with outer membrane 63 232 1.2E-15 T 21-04-2016 SPH21_RS00950 ee61a11612b0da08606851f6212ed954 544 SUPERFAMILY SSF48452 32 544 1.39E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00950 ee61a11612b0da08606851f6212ed954 544 Gene3D G3DSA:1.25.40.10 401 492 3.3E-41 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00950 ee61a11612b0da08606851f6212ed954 544 Gene3D G3DSA:1.25.40.10 215 309 3.3E-41 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10890 a5801304af95349cbf0d4b54106ce5d6 439 SUPERFAMILY SSF111352 37 421 8.37E-108 T 21-04-2016 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 SPH21_RS10890 a5801304af95349cbf0d4b54106ce5d6 439 PANTHER PTHR11730 14 437 6.3E-161 T 21-04-2016 IPR001905 Ammonium transporter GO:0008519|GO:0016020|GO:0072488 SPH21_RS10890 a5801304af95349cbf0d4b54106ce5d6 439 TIGRFAM TIGR00836 amt: ammonium transporter 41 438 3.9E-125 T 21-04-2016 IPR001905 Ammonium transporter GO:0008519|GO:0016020|GO:0072488 SPH21_RS10890 a5801304af95349cbf0d4b54106ce5d6 439 Gene3D G3DSA:1.10.3430.10 36 421 5.2E-119 T 21-04-2016 IPR029020 Ammonium/urea transporter SPH21_RS10890 a5801304af95349cbf0d4b54106ce5d6 439 Pfam PF00909 Ammonium Transporter Family 43 438 3.9E-112 T 21-04-2016 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 SPH21_RS10890 a5801304af95349cbf0d4b54106ce5d6 439 PANTHER PTHR11730:SF17 14 437 6.3E-161 T 21-04-2016 SPH21_RS03650 ce752c6bba87e0424e2c49ac37590bf6 393 SUPERFAMILY SSF52768 40 309 2.16E-57 T 21-04-2016 SPH21_RS03650 ce752c6bba87e0424e2c49ac37590bf6 393 Gene3D G3DSA:3.40.800.10 34 312 1.0E-48 T 21-04-2016 IPR023696 Ureohydrolase domain SPH21_RS03650 ce752c6bba87e0424e2c49ac37590bf6 393 PANTHER PTHR11358:SF26 40 323 1.8E-24 T 21-04-2016 SPH21_RS03650 ce752c6bba87e0424e2c49ac37590bf6 393 PANTHER PTHR11358 40 323 1.8E-24 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS03650 ce752c6bba87e0424e2c49ac37590bf6 393 Pfam PF00491 Arginase family 46 303 5.7E-28 T 21-04-2016 IPR006035 Ureohydrolase GO:0046872 Reactome: REACT_13 SPH21_RS21615 166c436bc59ed9e6a26678e2eb0787a7 182 SUPERFAMILY SSF48150 3 172 1.26E-51 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS21615 166c436bc59ed9e6a26678e2eb0787a7 182 PANTHER PTHR30037 1 182 8.3E-68 T 21-04-2016 SPH21_RS21615 166c436bc59ed9e6a26678e2eb0787a7 182 PANTHER PTHR30037:SF4 1 182 8.3E-68 T 21-04-2016 SPH21_RS21615 166c436bc59ed9e6a26678e2eb0787a7 182 Pfam PF03352 Methyladenine glycosylase 16 126 5.0E-41 T 21-04-2016 IPR005019 Methyladenine glycosylase GO:0006284|GO:0008725 SPH21_RS21615 166c436bc59ed9e6a26678e2eb0787a7 182 Gene3D G3DSA:1.10.340.30 3 169 2.1E-49 T 21-04-2016 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: REACT_216 SPH21_RS01245 5f4f948a39fce2e8a54b5e941d61142b 287 Pfam PF09357 RteC protein 63 276 1.2E-65 T 21-04-2016 IPR018534 Tetracycline regulation of excision, RteC SPH21_RS04915 69cef54b4dc27bc64c899823cd0dd988 466 Gene3D G3DSA:1.25.40.10 206 409 9.8E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04915 69cef54b4dc27bc64c899823cd0dd988 466 Pfam PF07980 SusD family 332 466 4.6E-22 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04915 69cef54b4dc27bc64c899823cd0dd988 466 Pfam PF14322 Starch-binding associating with outer membrane 25 224 2.1E-29 T 21-04-2016 SPH21_RS04915 69cef54b4dc27bc64c899823cd0dd988 466 SUPERFAMILY SSF48452 20 466 1.39E-92 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13230 141b0d34b9f1a7d97be661e1a42175dd 335 Pfam PF00664 ABC transporter transmembrane region 29 294 3.4E-8 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS13230 141b0d34b9f1a7d97be661e1a42175dd 335 SUPERFAMILY SSF90123 12 327 1.31E-29 T 21-04-2016 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SPH21_RS13230 141b0d34b9f1a7d97be661e1a42175dd 335 Gene3D G3DSA:1.20.1560.10 15 325 1.6E-24 T 21-04-2016 SPH21_RS14535 043486a41639fbfb22f78344935c17bf 140 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 130 4.8E-13 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS14535 043486a41639fbfb22f78344935c17bf 140 PANTHER PTHR36503 2 136 1.8E-39 T 21-04-2016 SPH21_RS14535 043486a41639fbfb22f78344935c17bf 140 Gene3D G3DSA:3.10.180.10 1 136 1.0E-39 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS14535 043486a41639fbfb22f78344935c17bf 140 PANTHER PTHR36503:SF1 2 136 1.8E-39 T 21-04-2016 SPH21_RS14535 043486a41639fbfb22f78344935c17bf 140 SUPERFAMILY SSF54593 4 137 1.0E-27 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS26115 22080edb00fce7273fdf6d5bba06f3df 594 PANTHER PTHR34978:SF2 102 335 1.3E-33 T 21-04-2016 SPH21_RS26115 22080edb00fce7273fdf6d5bba06f3df 594 Pfam PF05569 BlaR1 peptidase M56 104 294 4.8E-33 T 21-04-2016 IPR008756 Peptidase M56 SPH21_RS26115 22080edb00fce7273fdf6d5bba06f3df 594 PANTHER PTHR34978 102 335 1.3E-33 T 21-04-2016 SPH21_RS26115 22080edb00fce7273fdf6d5bba06f3df 594 Gene3D G3DSA:3.30.2010.10 144 216 1.8E-4 T 21-04-2016 SPH21_RS10225 c5fab5abda18521e65882416adf6fc61 509 PANTHER PTHR30250 1 509 1.2E-62 T 21-04-2016 SPH21_RS10225 c5fab5abda18521e65882416adf6fc61 509 PANTHER PTHR30250:SF7 1 509 1.2E-62 T 21-04-2016 SPH21_RS10225 c5fab5abda18521e65882416adf6fc61 509 Pfam PF01943 Polysaccharide biosynthesis protein 10 294 1.9E-9 T 21-04-2016 IPR002797 Polysaccharide biosynthesis protein GO:0016020 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 PIRSF PIRSF002144 1 88 2.3E-33 T 21-04-2016 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 PRINTS PR00975 Ribosomal protein S19 family signature 33 52 2.0E-23 T 21-04-2016 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 PRINTS PR00975 Ribosomal protein S19 family signature 65 80 2.0E-23 T 21-04-2016 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 PRINTS PR00975 Ribosomal protein S19 family signature 53 65 2.0E-23 T 21-04-2016 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 Hamap MF_00531 30S ribosomal protein S19 [rpsS]. 1 88 24.291 T 21-04-2016 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 PANTHER PTHR11880 1 88 2.3E-47 T 21-04-2016 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 SUPERFAMILY SSF54570 3 84 4.71E-35 T 21-04-2016 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 TIGRFAM TIGR01050 rpsS_bact: ribosomal protein uS19 1 88 3.6E-45 T 21-04-2016 IPR005732 Ribosomal protein S19, bacterial-type GO:0003735|GO:0006412|GO:0015935 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 ProSitePatterns PS00323 Ribosomal protein S19 signature. 53 77 - T 21-04-2016 IPR020934 Ribosomal protein S19 conserved site GO:0003723 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 Pfam PF00203 Ribosomal protein S19 3 83 8.7E-37 T 21-04-2016 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08515 b956943b9c463d272f59d9a965be0706 88 Gene3D G3DSA:3.30.860.10 1 88 8.9E-41 T 21-04-2016 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 SPH21_RS06555 cf149dfa52d2c24316efd0f61a23d97d 121 Pfam PF11325 Domain of unknown function (DUF3127) 2 89 7.1E-26 T 21-04-2016 IPR021474 Protein of unknown function DUF3127 SPH21_RS06555 cf149dfa52d2c24316efd0f61a23d97d 121 Gene3D G3DSA:2.40.50.140 33 121 8.0E-6 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS06555 cf149dfa52d2c24316efd0f61a23d97d 121 SUPERFAMILY SSF50249 47 121 1.07E-6 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS04485 347046db024ec89a000323882178b1e7 118 SUPERFAMILY SSF159888 4 114 3.01E-16 T 21-04-2016 SPH21_RS04485 347046db024ec89a000323882178b1e7 118 Pfam PF08818 Domain of unknown function (DU1801) 18 112 2.8E-14 T 21-04-2016 IPR014922 Domain of unknown function DUF1801 SPH21_RS18335 e1516b52365d660719f07d489cf487a0 73 Pfam PF09360 Iron-binding zinc finger CDGSH type 11 57 9.9E-19 T 21-04-2016 IPR018967 Iron sulphur-containing domain, CDGSH-type GO:0043231|GO:0051537 SPH21_RS18335 e1516b52365d660719f07d489cf487a0 73 SMART SM00704 21 62 1.4E-9 T 21-04-2016 IPR018967 Iron sulphur-containing domain, CDGSH-type GO:0043231|GO:0051537 SPH21_RS19935 e434ea07381e34d83472ba05515a2cef 483 Pfam PF01458 Uncharacterized protein family (UPF0051) 221 454 6.4E-68 T 21-04-2016 IPR000825 SUF system FeS cluster assembly, SufBD GO:0016226 SPH21_RS19935 e434ea07381e34d83472ba05515a2cef 483 TIGRFAM TIGR01980 sufB: FeS assembly protein SufB 16 474 3.4E-195 T 21-04-2016 IPR010231 SUF system FeS cluster assembly, SufB GO:0016226 SPH21_RS19935 e434ea07381e34d83472ba05515a2cef 483 PANTHER PTHR30508:SF1 9 483 0.0 T 21-04-2016 SPH21_RS19935 e434ea07381e34d83472ba05515a2cef 483 PANTHER PTHR30508 9 483 0.0 T 21-04-2016 SPH21_RS19935 e434ea07381e34d83472ba05515a2cef 483 SUPERFAMILY SSF101960 37 480 2.22E-138 T 21-04-2016 SPH21_RS15275 535acd57e6df2df0e94693a13cb1cd7c 334 PANTHER PTHR33371 1 217 5.1E-15 T 21-04-2016 SPH21_RS15275 535acd57e6df2df0e94693a13cb1cd7c 334 Pfam PF02470 MlaD protein 48 117 3.3E-15 T 21-04-2016 IPR003399 Mce/MlaD SPH21_RS24870 e372124c7b5e0f558ed6652411f2855c 127 PANTHER PTHR41327 1 127 6.7E-26 T 21-04-2016 SPH21_RS24870 e372124c7b5e0f558ed6652411f2855c 127 Pfam PF08818 Domain of unknown function (DU1801) 24 111 1.6E-13 T 21-04-2016 IPR014922 Domain of unknown function DUF1801 SPH21_RS24870 e372124c7b5e0f558ed6652411f2855c 127 PANTHER PTHR41327:SF1 1 127 6.7E-26 T 21-04-2016 SPH21_RS24870 e372124c7b5e0f558ed6652411f2855c 127 SUPERFAMILY SSF159888 7 120 1.7E-26 T 21-04-2016 SPH21_RS21855 0e015d99eb3bfa6de12ff43666067f38 517 Pfam PF02652 L-lactate permease 325 500 3.0E-61 T 21-04-2016 IPR003804 L-lactate permease GO:0005887|GO:0015129|GO:0015727 SPH21_RS21855 0e015d99eb3bfa6de12ff43666067f38 517 Pfam PF02652 L-lactate permease 20 309 9.0E-94 T 21-04-2016 IPR003804 L-lactate permease GO:0005887|GO:0015129|GO:0015727 SPH21_RS21855 0e015d99eb3bfa6de12ff43666067f38 517 PANTHER PTHR30003:SF0 19 510 1.8E-206 T 21-04-2016 SPH21_RS21855 0e015d99eb3bfa6de12ff43666067f38 517 TIGRFAM TIGR00795 lctP: transporter, lactate permease (LctP) family 19 502 8.2E-149 T 21-04-2016 IPR003804 L-lactate permease GO:0005887|GO:0015129|GO:0015727 SPH21_RS21855 0e015d99eb3bfa6de12ff43666067f38 517 PANTHER PTHR30003 19 510 1.8E-206 T 21-04-2016 IPR003804 L-lactate permease GO:0005887|GO:0015129|GO:0015727 SPH21_RS03615 cfe48704a2786f3b5c10ccd620b97b08 118 Pfam PF13380 CoA binding domain 3 112 9.0E-20 T 21-04-2016 IPR003781 CoA-binding GO:0048037 SPH21_RS03615 cfe48704a2786f3b5c10ccd620b97b08 118 Gene3D G3DSA:3.40.50.720 2 116 6.2E-26 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03615 cfe48704a2786f3b5c10ccd620b97b08 118 SUPERFAMILY SSF51735 3 117 3.35E-20 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03745 8cfa74a9248cc38b24d20b8a7b1bd7e7 279 PANTHER PTHR38477 65 266 1.7E-60 T 21-04-2016 SPH21_RS03745 8cfa74a9248cc38b24d20b8a7b1bd7e7 279 PANTHER PTHR38477:SF1 65 266 1.7E-60 T 21-04-2016 SPH21_RS03745 8cfa74a9248cc38b24d20b8a7b1bd7e7 279 Pfam PF13645 L,D-transpeptidase catalytic domain 67 234 6.0E-62 T 21-04-2016 IPR032676 Putative L,D-transpeptidase catalytic domain SPH21_RS21670 e0080fd348eb35259d1954cced0ef9c9 206 Pfam PF13568 Outer membrane protein beta-barrel domain 23 186 1.6E-19 T 21-04-2016 IPR025665 Outer membrane protein beta-barrel domain SPH21_RS21670 e0080fd348eb35259d1954cced0ef9c9 206 Gene3D G3DSA:2.40.160.20 44 206 2.9E-7 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS21670 e0080fd348eb35259d1954cced0ef9c9 206 SUPERFAMILY SSF56925 39 206 4.16E-5 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS06465 bcac37e8bdb06b2c1247be291d26fd04 111 Pfam PF05154 TM2 domain 46 85 1.8E-9 T 21-04-2016 IPR007829 TM2 domain SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 SUPERFAMILY SSF52788 1 134 2.22E-44 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 4 132 7.7E-23 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 Gene3D G3DSA:3.40.50.270 1 134 7.9E-46 T 21-04-2016 SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 SMART SM00226 2 135 1.8E-46 T 21-04-2016 IPR023485 Phosphotyrosine protein phosphatase I superfamily SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 PANTHER PTHR11717:SF18 1 135 4.2E-40 T 21-04-2016 SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 38 54 5.6E-5 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 4 21 5.6E-5 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 72 87 5.6E-5 T 21-04-2016 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SPH21_RS01135 d9ffb690903cf96eeb099599cd5840d8 145 PANTHER PTHR11717 1 135 4.2E-40 T 21-04-2016 SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 SUPERFAMILY SSF52540 71 358 1.37E-71 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 PANTHER PTHR24031 1 416 1.9E-191 T 21-04-2016 SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 PANTHER PTHR24031 504 594 1.9E-191 T 21-04-2016 SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 Gene3D G3DSA:3.40.50.300 210 369 2.3E-48 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 Pfam PF00271 Helicase conserved C-terminal domain 246 337 2.9E-26 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 SMART SM00490 256 337 3.8E-31 T 21-04-2016 IPR001650 Helicase, C-terminal SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 Gene3D G3DSA:3.40.50.300 2 209 4.5E-77 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 Pfam PF03880 DbpA RNA binding domain 469 539 1.3E-21 T 21-04-2016 IPR005580 DbpA, RNA-binding domain SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 Pfam PF00270 DEAD/DEAH box helicase 26 193 7.9E-50 T 21-04-2016 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 ProSitePatterns PS00039 DEAD-box subfamily ATP-dependent helicases signature. 151 159 - T 21-04-2016 IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 PANTHER PTHR24031:SF261 1 416 1.9E-191 T 21-04-2016 SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 PANTHER PTHR24031:SF261 504 594 1.9E-191 T 21-04-2016 SPH21_RS19255 6c68cf4cf6f2340ad85c39783e83b99e 597 SMART SM00487 21 220 2.7E-65 T 21-04-2016 IPR014001 Helicase superfamily 1/2, ATP-binding domain SPH21_RS25430 11107ec9e061c19b80c7a709fb16b847 158 Pfam PF02566 OsmC-like protein 52 144 2.1E-14 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS25430 11107ec9e061c19b80c7a709fb16b847 158 Gene3D G3DSA:3.30.300.20 2 152 1.5E-54 T 21-04-2016 IPR015946 K homology domain-like, alpha/beta SPH21_RS25430 11107ec9e061c19b80c7a709fb16b847 158 SUPERFAMILY SSF82784 5 150 3.66E-39 T 21-04-2016 IPR003718 OsmC/Ohr family SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 ProSitePatterns PS00760 Signal peptidases I lysine active site. 248 260 - T 21-04-2016 IPR019757 Peptidase S26A, signal peptidase I, lysine active site GO:0008236|GO:0016021 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 412 454 1.3E-13 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 131 272 9.7E-24 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 ProSitePatterns PS00761 Signal peptidases I signature 3. 419 432 - T 21-04-2016 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PANTHER PTHR12383 122 178 5.5E-57 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PANTHER PTHR12383 396 468 5.5E-57 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PANTHER PTHR12383 215 292 5.5E-57 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 414 433 1.2E-17 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 146 162 1.2E-17 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 246 258 1.2E-17 T 21-04-2016 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PANTHER PTHR12383:SF14 122 178 5.5E-57 T 21-04-2016 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PANTHER PTHR12383:SF14 396 468 5.5E-57 T 21-04-2016 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 PANTHER PTHR12383:SF14 215 292 5.5E-57 T 21-04-2016 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 Gene3D G3DSA:2.10.109.10 414 468 5.2E-53 T 21-04-2016 IPR028360 Peptidase S24/S26, beta-ribbon domain SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 Gene3D G3DSA:2.10.109.10 142 256 5.2E-53 T 21-04-2016 IPR028360 Peptidase S24/S26, beta-ribbon domain SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 Pfam PF10502 Signal peptidase, peptidase S26 400 451 4.8E-5 T 21-04-2016 IPR019533 Peptidase S26 SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 Pfam PF00717 Peptidase S24-like 153 270 2.5E-12 T 21-04-2016 IPR019759 Peptidase S24/S26A/S26B SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 SUPERFAMILY SSF51306 211 281 2.72E-53 T 21-04-2016 IPR015927 Peptidase S24/S26A/S26B/S26C SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 SUPERFAMILY SSF51306 352 471 2.72E-53 T 21-04-2016 IPR015927 Peptidase S24/S26A/S26B/S26C SPH21_RS02085 7d3c4388c420d86dd08a2ec02177692e 474 SUPERFAMILY SSF51306 144 184 2.72E-53 T 21-04-2016 IPR015927 Peptidase S24/S26A/S26B/S26C SPH21_RS03060 b9f347e168aced955d27e6e02a8eb0c1 142 Pfam PF16303 Domain of unknown function (DUF4945) 19 138 2.4E-56 T 21-04-2016 IPR032544 Protein of unknown function DUF4945 SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 Gene3D G3DSA:3.30.559.10 4 208 5.6E-77 T 21-04-2016 IPR023213 Chloramphenicol acetyltransferase-like domain SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 PIRSF PIRSF000440 2 214 1.4E-69 T 21-04-2016 IPR001707 Chloramphenicol acetyltransferase GO:0008811 SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 SMART SM01059 1 205 8.1E-80 T 21-04-2016 IPR001707 Chloramphenicol acetyltransferase GO:0008811 SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 PANTHER PTHR38474:SF2 5 217 8.3E-59 T 21-04-2016 SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 SUPERFAMILY SSF52777 2 211 4.17E-59 T 21-04-2016 SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 PANTHER PTHR38474 5 217 8.3E-59 T 21-04-2016 SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 ProDom PD002660 TRANSFERASE CHLORAMPHENICOL ACYLTRANSFERASE ACETYLTRANSFERASE ANTIBIOTIC RESISTANCE PLASMID CAT O-ACETYLTRANSFERASE DIRECT 10 203 6.0E-50 T 21-04-2016 IPR001707 Chloramphenicol acetyltransferase GO:0008811 SPH21_RS18845 74d5a044eaa7c0f23243ac31c5903768 217 Pfam PF00302 Chloramphenicol acetyltransferase 2 205 2.6E-65 T 21-04-2016 IPR001707 Chloramphenicol acetyltransferase GO:0008811 SPH21_RS20945 9ca4546f0b39636fc1949d3435f179de 196 Pfam PF02525 Flavodoxin-like fold 1 177 1.1E-33 T 21-04-2016 IPR003680 Flavodoxin-like fold SPH21_RS20945 9ca4546f0b39636fc1949d3435f179de 196 SUPERFAMILY SSF52218 1 195 1.02E-41 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS20945 9ca4546f0b39636fc1949d3435f179de 196 Gene3D G3DSA:3.40.50.360 1 194 2.1E-43 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS20945 9ca4546f0b39636fc1949d3435f179de 196 PANTHER PTHR10204 1 185 5.0E-27 T 21-04-2016 SPH21_RS20945 9ca4546f0b39636fc1949d3435f179de 196 PANTHER PTHR10204:SF40 1 185 5.0E-27 T 21-04-2016 SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 Gene3D G3DSA:2.60.40.1120 12 105 5.9E-7 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 SUPERFAMILY SSF49452 5 73 1.75E-8 T 21-04-2016 IPR013784 Carbohydrate-binding-like fold GO:0030246 SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 SUPERFAMILY SSF56935 94 748 1.79E-50 T 21-04-2016 SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 Pfam PF14905 Outer membrane protein beta-barrel family 348 746 3.9E-81 T 21-04-2016 SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 Pfam PF13620 Carboxypeptidase regulatory-like domain 12 83 3.5E-7 T 21-04-2016 SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 Gene3D G3DSA:2.40.170.20 204 660 5.9E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 Gene3D G3DSA:2.40.170.20 724 757 5.9E-33 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24475 724be6877ba28293354a7ec5988d2c72 769 Gene3D G3DSA:2.170.130.10 124 203 6.7E-5 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS07710 542be6b3251a1de3d00d75600c5ddf5f 195 Gene3D G3DSA:1.20.120.80 18 193 2.5E-30 T 21-04-2016 IPR013833 Cytochrome c oxidase, subunit III, 4-helical bundle GO:0004129|GO:0016020|GO:0022904 SPH21_RS07710 542be6b3251a1de3d00d75600c5ddf5f 195 PANTHER PTHR11403 25 191 1.8E-17 T 21-04-2016 IPR024791 Cytochrome c oxidase subunit III GO:0015002|GO:0016020|GO:0019646 SPH21_RS07710 542be6b3251a1de3d00d75600c5ddf5f 195 SUPERFAMILY SSF81452 15 191 1.83E-29 T 21-04-2016 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 SPH21_RS07710 542be6b3251a1de3d00d75600c5ddf5f 195 Pfam PF00510 Cytochrome c oxidase subunit III 51 191 3.6E-7 T 21-04-2016 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 SPH21_RS07710 542be6b3251a1de3d00d75600c5ddf5f 195 PANTHER PTHR11403:SF0 25 191 1.8E-17 T 21-04-2016 SPH21_RS17580 1d8031757782105f3ba929593bb3836b 112 SUPERFAMILY SSF50022 15 101 7.46E-17 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS17580 1d8031757782105f3ba929593bb3836b 112 Gene3D G3DSA:2.102.10.10 16 102 1.4E-19 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS17580 1d8031757782105f3ba929593bb3836b 112 Pfam PF00355 Rieske [2Fe-2S] domain 16 77 2.7E-12 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS24955 24d1e9173c92a3c6c261bedd9122f57b 194 SUPERFAMILY SSF53335 7 187 4.37E-26 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS24955 24d1e9173c92a3c6c261bedd9122f57b 194 Pfam PF13649 Methyltransferase domain 43 134 5.9E-15 T 21-04-2016 SPH21_RS24955 24d1e9173c92a3c6c261bedd9122f57b 194 Gene3D G3DSA:3.40.50.150 7 187 4.4E-27 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS24955 24d1e9173c92a3c6c261bedd9122f57b 194 PANTHER PTHR10108 7 181 2.1E-16 T 21-04-2016 SPH21_RS24955 24d1e9173c92a3c6c261bedd9122f57b 194 PANTHER PTHR10108:SF705 7 181 2.1E-16 T 21-04-2016 SPH21_RS25930 855f6af55424f741f587a0a3dcd103c3 164 Gene3D G3DSA:3.30.70.1450 85 159 3.7E-16 T 21-04-2016 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SPH21_RS25930 855f6af55424f741f587a0a3dcd103c3 164 Pfam PF02080 TrkA-C domain 90 158 1.1E-10 T 21-04-2016 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SPH21_RS25930 855f6af55424f741f587a0a3dcd103c3 164 SUPERFAMILY SSF116726 73 158 3.01E-14 T 21-04-2016 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SPH21_RS25930 855f6af55424f741f587a0a3dcd103c3 164 PANTHER PTHR30445 4 158 9.5E-40 T 21-04-2016 SPH21_RS25930 855f6af55424f741f587a0a3dcd103c3 164 PIRSF PIRSF005028 1 162 1.3E-50 T 21-04-2016 IPR026278 Potassium/proton antiporter subunit KhtT SPH21_RS26125 210212c8a41d1823edf731d16435a224 347 Pfam PF01551 Peptidase family M23 196 290 1.0E-15 T 21-04-2016 IPR016047 Peptidase M23 SPH21_RS26125 210212c8a41d1823edf731d16435a224 347 PANTHER PTHR21666 199 215 2.2E-12 T 21-04-2016 SPH21_RS26125 210212c8a41d1823edf731d16435a224 347 PANTHER PTHR21666 231 288 2.2E-12 T 21-04-2016 SPH21_RS26125 210212c8a41d1823edf731d16435a224 347 Gene3D G3DSA:2.70.70.10 193 290 4.4E-23 T 21-04-2016 SPH21_RS26125 210212c8a41d1823edf731d16435a224 347 SUPERFAMILY SSF51261 176 288 3.14E-21 T 21-04-2016 IPR011055 Duplicated hybrid motif SPH21_RS15075 959fd198d6b48fdf3bb0d9344f866ba4 210 PANTHER PTHR12863:SF1 10 210 1.1E-59 T 21-04-2016 SPH21_RS15075 959fd198d6b48fdf3bb0d9344f866ba4 210 Pfam PF04116 Fatty acid hydroxylase superfamily 62 201 1.7E-19 T 21-04-2016 IPR006694 Fatty acid hydroxylase GO:0005506|GO:0006633|GO:0016491|GO:0055114 SPH21_RS15075 959fd198d6b48fdf3bb0d9344f866ba4 210 PANTHER PTHR12863 10 210 1.1E-59 T 21-04-2016 SPH21_RS13930 7f1c558806a88157ddae8554d29c46d9 185 Pfam PF11827 Protein of unknown function (DUF3347) 18 179 1.0E-45 T 21-04-2016 IPR021782 Protein of unknown function DUF3347 SPH21_RS11215 93ac162cb17738c52cbc1a81ff496a06 267 Pfam PF06283 Trehalose utilisation 55 264 8.6E-83 T 21-04-2016 IPR029010 ThuA-like domain SPH21_RS11215 93ac162cb17738c52cbc1a81ff496a06 267 Gene3D G3DSA:3.40.50.880 55 266 3.3E-43 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS11215 93ac162cb17738c52cbc1a81ff496a06 267 SUPERFAMILY SSF52317 55 267 2.98E-54 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS11215 93ac162cb17738c52cbc1a81ff496a06 267 PANTHER PTHR40469 55 265 8.4E-50 T 21-04-2016 SPH21_RS11215 93ac162cb17738c52cbc1a81ff496a06 267 PANTHER PTHR40469:SF1 55 265 8.4E-50 T 21-04-2016 SPH21_RS11665 4660a79ec174d6f4259a2f197870271a 130 Pfam PF00293 NUDIX domain 11 109 2.1E-11 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS11665 4660a79ec174d6f4259a2f197870271a 130 SUPERFAMILY SSF55811 5 111 1.15E-20 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS11665 4660a79ec174d6f4259a2f197870271a 130 PANTHER PTHR22769 5 108 2.2E-13 T 21-04-2016 SPH21_RS11665 4660a79ec174d6f4259a2f197870271a 130 Gene3D G3DSA:3.90.79.10 7 126 4.6E-19 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS11665 4660a79ec174d6f4259a2f197870271a 130 ProSitePatterns PS00893 Nudix box signature. 31 52 - T 21-04-2016 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SPH21_RS03930 0c321fa6a00d569301361010723c2a1a 377 PANTHER PTHR23028 1 361 2.2E-71 T 21-04-2016 SPH21_RS03930 0c321fa6a00d569301361010723c2a1a 377 Pfam PF01757 Acyltransferase family 28 349 7.1E-25 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS03930 0c321fa6a00d569301361010723c2a1a 377 PANTHER PTHR23028:SF54 1 361 2.2E-71 T 21-04-2016 SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 PANTHER PTHR30572 409 803 2.9E-61 T 21-04-2016 SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 PANTHER PTHR30572 307 368 2.9E-61 T 21-04-2016 SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 PANTHER PTHR30572:SF4 409 803 2.9E-61 T 21-04-2016 SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 PANTHER PTHR30572:SF4 307 368 2.9E-61 T 21-04-2016 SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 Pfam PF12704 MacB-like periplasmic core domain 482 646 5.8E-10 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 Pfam PF12704 MacB-like periplasmic core domain 30 252 1.6E-15 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 Pfam PF02687 FtsX-like permease family 298 412 2.4E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS21575 7f0b73a5a8736911a227ffccc7843966 803 Pfam PF02687 FtsX-like permease family 683 792 1.1E-9 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS17610 6246bb9b1c8ccf7e83da2b0acc5d5841 174 Gene3D G3DSA:3.10.129.10 5 156 5.4E-54 T 21-04-2016 IPR029069 HotDog domain SPH21_RS17610 6246bb9b1c8ccf7e83da2b0acc5d5841 174 Pfam PF03061 Thioesterase superfamily 26 97 2.5E-17 T 21-04-2016 IPR006683 Thioesterase domain SPH21_RS17610 6246bb9b1c8ccf7e83da2b0acc5d5841 174 SUPERFAMILY SSF54637 2 150 1.28E-45 T 21-04-2016 IPR029069 HotDog domain SPH21_RS17610 6246bb9b1c8ccf7e83da2b0acc5d5841 174 PANTHER PTHR11049 8 150 1.1E-59 T 21-04-2016 SPH21_RS22570 87fb2ac706e03f83cac2cc90bf26dca7 162 TIGRFAM TIGR02246 TIGR02246: conserved hypothetical protein 22 147 1.1E-16 T 21-04-2016 IPR011944 Steroid delta5-4-isomerase KEGG: 00140+5.3.3.1|KEGG: 00984+5.3.3.1|MetaCyc: PWY-2582|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-6948|MetaCyc: PWY-699|MetaCyc: PWY-7299 SPH21_RS22570 87fb2ac706e03f83cac2cc90bf26dca7 162 Gene3D G3DSA:3.10.450.50 14 156 4.6E-38 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS22570 87fb2ac706e03f83cac2cc90bf26dca7 162 SUPERFAMILY SSF54427 22 151 6.53E-28 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS22570 87fb2ac706e03f83cac2cc90bf26dca7 162 Pfam PF14534 Domain of unknown function (DUF4440) 26 140 4.1E-9 T 21-04-2016 IPR027843 Domain of unknown function DUF4440 SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 Gene3D G3DSA:3.40.50.150 2 204 3.2E-30 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 Pfam PF00145 C-5 cytosine-specific DNA methylase 7 525 6.4E-25 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 SUPERFAMILY SSF53335 234 278 7.75E-43 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 SUPERFAMILY SSF53335 5 203 7.75E-43 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 SUPERFAMILY SSF53335 331 358 7.75E-43 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 SUPERFAMILY SSF53335 467 525 7.75E-43 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 Gene3D G3DSA:3.90.120.10 245 246 1.3E-11 T 21-04-2016 SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 Gene3D G3DSA:3.90.120.10 331 367 1.3E-11 T 21-04-2016 SPH21_RS17400 48c56fb428c23084f95f38a5278cb8ab 531 Gene3D G3DSA:3.90.120.10 462 517 1.3E-11 T 21-04-2016 SPH21_RS00215 d2684c75ab8404a6185684bd042f928a 127 SUPERFAMILY SSF109635 7 94 2.35E-7 T 21-04-2016 SPH21_RS00215 d2684c75ab8404a6185684bd042f928a 127 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 93 122 9.9E-6 T 21-04-2016 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 SPH21_RS00215 d2684c75ab8404a6185684bd042f928a 127 PANTHER PTHR33823 2 126 1.3E-23 T 21-04-2016 SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 1.1E-8 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 1.1E-8 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 SUPERFAMILY SSF48498 79 173 1.09E-11 T 21-04-2016 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 ProSitePatterns PS01081 TetR-type HTH domain signature. 23 54 - T 21-04-2016 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 Gene3D G3DSA:1.10.357.10 9 207 2.0E-40 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 SUPERFAMILY SSF46689 7 77 7.7E-18 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 6.2E-18 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 PANTHER PTHR30055:SF73 11 179 7.0E-27 T 21-04-2016 SPH21_RS08280 69f9722f6f835daab17f52c6d81e2fa8 213 PANTHER PTHR30055 11 179 7.0E-27 T 21-04-2016 SPH21_RS24160 a0c0ac97cccc006a007bc61ec9ceb9f3 378 PANTHER PTHR30158 1 374 3.5E-95 T 21-04-2016 SPH21_RS24160 a0c0ac97cccc006a007bc61ec9ceb9f3 378 Gene3D G3DSA:2.40.50.100 58 91 5.5E-21 T 21-04-2016 SPH21_RS24160 a0c0ac97cccc006a007bc61ec9ceb9f3 378 Gene3D G3DSA:2.40.50.100 166 194 5.5E-21 T 21-04-2016 SPH21_RS24160 a0c0ac97cccc006a007bc61ec9ceb9f3 378 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 34 367 3.8E-80 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS24160 a0c0ac97cccc006a007bc61ec9ceb9f3 378 SUPERFAMILY SSF111369 46 290 4.84E-51 T 21-04-2016 SPH21_RS24160 a0c0ac97cccc006a007bc61ec9ceb9f3 378 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 59 284 5.7E-11 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS05010 8cc6fe6899405f78ea1a36ddd4845b1b 594 PANTHER PTHR33361:SF6 414 573 1.2E-14 T 21-04-2016 SPH21_RS05010 8cc6fe6899405f78ea1a36ddd4845b1b 594 PANTHER PTHR33361 414 573 1.2E-14 T 21-04-2016 SPH21_RS05010 8cc6fe6899405f78ea1a36ddd4845b1b 594 Pfam PF05960 Bacterial protein of unknown function (DUF885) 76 573 2.5E-72 T 21-04-2016 IPR010281 Protein of unknown function DUF885 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 PANTHER PTHR30572 605 813 1.1E-53 T 21-04-2016 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 PANTHER PTHR30572 405 583 1.1E-53 T 21-04-2016 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 PANTHER PTHR30572 297 357 1.1E-53 T 21-04-2016 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 PANTHER PTHR30572:SF4 605 813 1.1E-53 T 21-04-2016 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 PANTHER PTHR30572:SF4 405 583 1.1E-53 T 21-04-2016 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 PANTHER PTHR30572:SF4 297 357 1.1E-53 T 21-04-2016 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 Pfam PF02687 FtsX-like permease family 693 806 7.7E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 Pfam PF02687 FtsX-like permease family 292 405 2.8E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05970 64311b54e3d153a056eb75abb29275d0 813 Pfam PF12704 MacB-like periplasmic core domain 21 243 1.8E-13 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS17960 aae1e1e0f68e624628f1e3f46aa2b996 275 Pfam PF09357 RteC protein 61 273 7.9E-82 T 21-04-2016 IPR018534 Tetracycline regulation of excision, RteC SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 SMART SM00354 5 75 2.3E-23 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 Gene3D G3DSA:3.40.50.2300 58 178 4.2E-37 T 21-04-2016 SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 SUPERFAMILY SSF53822 62 320 2.36E-47 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 52 3.2E-14 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 SUPERFAMILY SSF47413 4 63 8.81E-15 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 Gene3D G3DSA:1.10.260.40 6 57 1.7E-19 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 Gene3D G3DSA:3.40.50.2300 179 317 6.1E-26 T 21-04-2016 SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 PANTHER PTHR30146 5 332 1.5E-73 T 21-04-2016 SPH21_RS03135 db9c730fa9a822c3a5660781e8545454 338 Pfam PF00532 Periplasmic binding proteins and sugar binding domain of LacI family 65 332 1.2E-22 T 21-04-2016 IPR001761 Periplasmic binding protein/LacI sugar binding domain SPH21_RS00135 eff4176d956cf5587b350112ff67f8fc 352 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 47 348 7.2E-76 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS00135 eff4176d956cf5587b350112ff67f8fc 352 SUPERFAMILY SSF111369 60 273 2.09E-45 T 21-04-2016 SPH21_RS00135 eff4176d956cf5587b350112ff67f8fc 352 PANTHER PTHR30469:SF11 1 348 7.2E-78 T 21-04-2016 SPH21_RS00135 eff4176d956cf5587b350112ff67f8fc 352 Gene3D G3DSA:2.40.50.100 163 194 7.6E-19 T 21-04-2016 SPH21_RS00135 eff4176d956cf5587b350112ff67f8fc 352 Gene3D G3DSA:2.40.50.100 68 102 7.6E-19 T 21-04-2016 SPH21_RS00135 eff4176d956cf5587b350112ff67f8fc 352 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 55 268 2.4E-27 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS00135 eff4176d956cf5587b350112ff67f8fc 352 PANTHER PTHR30469 1 348 7.2E-78 T 21-04-2016 SPH21_RS14400 6ee110f777901874209f1c387a439633 389 PANTHER PTHR23514 5 386 2.5E-113 T 21-04-2016 SPH21_RS14400 6ee110f777901874209f1c387a439633 389 Pfam PF07690 Major Facilitator Superfamily 236 382 5.0E-12 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS14400 6ee110f777901874209f1c387a439633 389 Pfam PF07690 Major Facilitator Superfamily 21 190 2.4E-8 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS14400 6ee110f777901874209f1c387a439633 389 PANTHER PTHR23514:SF13 5 386 2.5E-113 T 21-04-2016 SPH21_RS14400 6ee110f777901874209f1c387a439633 389 SUPERFAMILY SSF103473 13 384 1.83E-40 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS14400 6ee110f777901874209f1c387a439633 389 Gene3D G3DSA:1.20.1250.20 212 382 4.8E-18 T 21-04-2016 SPH21_RS14400 6ee110f777901874209f1c387a439633 389 Gene3D G3DSA:1.20.1250.20 13 185 7.9E-17 T 21-04-2016 SPH21_RS06450 a50d8da7cb59e047401ce24671075bb3 970 Pfam PF04257 Exodeoxyribonuclease V, gamma subunit 443 619 6.4E-6 T 21-04-2016 SPH21_RS06450 a50d8da7cb59e047401ce24671075bb3 970 Gene3D G3DSA:3.40.50.300 444 612 3.1E-4 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06450 a50d8da7cb59e047401ce24671075bb3 970 SUPERFAMILY SSF52980 664 874 7.51E-8 T 21-04-2016 IPR011335 Restriction endonuclease type II-like SPH21_RS06450 a50d8da7cb59e047401ce24671075bb3 970 SUPERFAMILY SSF52540 286 624 1.33E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06450 a50d8da7cb59e047401ce24671075bb3 970 Pfam PF12705 PD-(D/E)XK nuclease superfamily 663 941 5.7E-29 T 21-04-2016 SPH21_RS17720 452c55c35dac3e6dd637e87e9fce31ab 324 Pfam PF00656 Caspase domain 2 214 2.6E-18 T 21-04-2016 SPH21_RS17720 452c55c35dac3e6dd637e87e9fce31ab 324 Gene3D G3DSA:3.40.50.1460 2 133 3.9E-9 T 21-04-2016 IPR029030 Caspase-like domain SPH21_RS17720 452c55c35dac3e6dd637e87e9fce31ab 324 SUPERFAMILY SSF52129 2 182 6.63E-17 T 21-04-2016 IPR029030 Caspase-like domain SPH21_RS10485 7943c6742ba2a5694b0cb3d16ad87edd 116 PANTHER PTHR33204 1 110 1.2E-35 T 21-04-2016 SPH21_RS10485 7943c6742ba2a5694b0cb3d16ad87edd 116 SUPERFAMILY SSF46785 10 111 5.89E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS10485 7943c6742ba2a5694b0cb3d16ad87edd 116 Pfam PF01638 HxlR-like helix-turn-helix 23 111 6.9E-30 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS10485 7943c6742ba2a5694b0cb3d16ad87edd 116 Gene3D G3DSA:1.10.10.10 6 113 7.7E-39 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24810 712578b9ca48f947ba3f2389b14b596e 340 PANTHER PTHR34580:SF3 1 340 3.7E-64 T 21-04-2016 SPH21_RS24810 712578b9ca48f947ba3f2389b14b596e 340 PANTHER PTHR34580 1 340 3.7E-64 T 21-04-2016 SPH21_RS24810 712578b9ca48f947ba3f2389b14b596e 340 Pfam PF13280 WYL domain 155 331 3.5E-26 T 21-04-2016 IPR026881 WYL domain SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 Gene3D G3DSA:1.10.260.40 6 55 7.8E-20 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 SUPERFAMILY SSF47413 3 61 1.59E-14 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 50 7.5E-12 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 Gene3D G3DSA:3.40.50.2300 56 173 7.3E-40 T 21-04-2016 SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 PANTHER PTHR30146 1 336 3.3E-90 T 21-04-2016 SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 SMART SM00354 3 73 5.0E-23 T 21-04-2016 IPR000843 Transcription regulator HTH, LacI GO:0003700|GO:0006355 SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 Pfam PF00532 Periplasmic binding proteins and sugar binding domain of LacI family 62 311 1.3E-26 T 21-04-2016 IPR001761 Periplasmic binding protein/LacI sugar binding domain SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 Gene3D G3DSA:3.40.50.2300 174 336 9.0E-40 T 21-04-2016 SPH21_RS00980 2fc5b7236cee4e95196981bb243ce0fd 339 SUPERFAMILY SSF53822 62 335 8.44E-57 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS25725 32ad462b3e5fac5cb2474d8056e74ece 209 Pfam PF13568 Outer membrane protein beta-barrel domain 14 191 2.5E-12 T 21-04-2016 IPR025665 Outer membrane protein beta-barrel domain SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 SUPERFAMILY SSF52172 3 132 3.7E-20 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 209 9.6E-17 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 SUPERFAMILY SSF46894 147 215 5.78E-17 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 Pfam PF00072 Response regulator receiver domain 5 116 3.3E-16 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 SMART SM00448 3 116 7.8E-11 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 Gene3D G3DSA:3.40.50.2300 2 158 1.0E-23 T 21-04-2016 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 PANTHER PTHR26402:SF151 3 214 3.8E-43 T 21-04-2016 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 PANTHER PTHR26402 3 214 3.8E-43 T 21-04-2016 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 Gene3D G3DSA:1.10.10.10 159 215 3.7E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 SMART SM00421 153 210 1.4E-16 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 1.4E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 1.4E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS24175 e87b6abc9a58ff3f5701c616dcad4b66 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 1.4E-9 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 SUPERFAMILY SSF88946 21 115 8.63E-21 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 SUPERFAMILY SSF88659 134 195 4.3E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 Gene3D G3DSA:1.10.1740.10 22 128 1.6E-21 T 21-04-2016 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 Gene3D G3DSA:1.10.10.10 131 196 3.8E-13 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 PANTHER PTHR30173 22 203 5.9E-36 T 21-04-2016 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 PANTHER PTHR30173:SF20 22 203 5.9E-36 T 21-04-2016 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 54 193 1.5E-25 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 Pfam PF04542 Sigma-70 region 2 57 107 1.4E-11 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS09475 6b66a4cecd068b8a94516c511c17b0ca 211 Pfam PF08281 Sigma-70, region 4 138 184 1.5E-12 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 PANTHER PTHR20941:SF1 16 278 1.5E-111 T 21-04-2016 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 ProSitePatterns PS00793 Dihydropteroate synthase signature 2. 52 65 - T 21-04-2016 IPR000489 Pterin-binding domain GO:0042558 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 Gene3D G3DSA:3.20.20.20 14 274 7.0E-100 T 21-04-2016 IPR000489 Pterin-binding domain GO:0042558 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 SUPERFAMILY SSF51717 6 271 1.26E-93 T 21-04-2016 IPR011005 Dihydropteroate synthase-like GO:0044237 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 PANTHER PTHR20941 16 278 1.5E-111 T 21-04-2016 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 Pfam PF00809 Pterin binding enzyme 19 258 1.1E-77 T 21-04-2016 IPR000489 Pterin-binding domain GO:0042558 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 TIGRFAM TIGR01496 DHPS: dihydropteroate synthase 17 270 5.4E-94 T 21-04-2016 IPR006390 Dihydropteroate synthase GO:0004156|GO:0009396 KEGG: 00790+2.5.1.15|MetaCyc: PWY-6614|UniPathway: UPA00077 SPH21_RS25855 76abe2f16a90ae973791a4438eac4c0c 285 ProSitePatterns PS00792 Dihydropteroate synthase signature 1. 18 33 - T 21-04-2016 IPR000489 Pterin-binding domain GO:0042558 SPH21_RS03205 4526ea935356ba825fb220be0db03c46 311 PANTHER PTHR36110 3 310 1.7E-124 T 21-04-2016 SPH21_RS03205 4526ea935356ba825fb220be0db03c46 311 SUPERFAMILY SSF54593 4 282 9.77E-51 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS03205 4526ea935356ba825fb220be0db03c46 311 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 7 97 3.7E-14 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS03205 4526ea935356ba825fb220be0db03c46 311 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 154 270 7.0E-19 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS03205 4526ea935356ba825fb220be0db03c46 311 PANTHER PTHR36110:SF2 3 310 1.7E-124 T 21-04-2016 SPH21_RS03205 4526ea935356ba825fb220be0db03c46 311 Gene3D G3DSA:3.10.180.10 3 137 1.5E-42 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS03205 4526ea935356ba825fb220be0db03c46 311 Gene3D G3DSA:3.10.180.10 138 310 1.6E-47 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS08950 084491a9980486b8fa2e2065cc3afa43 257 Gene3D G3DSA:3.10.560.10 137 224 2.1E-18 T 21-04-2016 SPH21_RS08950 084491a9980486b8fa2e2065cc3afa43 257 PANTHER PTHR33619 47 65 1.0E-40 T 21-04-2016 SPH21_RS08950 084491a9980486b8fa2e2065cc3afa43 257 PANTHER PTHR33619 92 235 1.0E-40 T 21-04-2016 SPH21_RS08950 084491a9980486b8fa2e2065cc3afa43 257 Gene3D G3DSA:3.30.1950.10 50 136 6.8E-20 T 21-04-2016 SPH21_RS08950 084491a9980486b8fa2e2065cc3afa43 257 Pfam PF02563 Polysaccharide biosynthesis/export protein 43 140 2.8E-20 T 21-04-2016 IPR003715 Polysaccharide export protein GO:0015159|GO:0015774|GO:0016020 SPH21_RS25255 b433958491e515a3d8a143e1251c98bd 329 Gene3D G3DSA:3.90.550.10 2 224 8.4E-43 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS25255 b433958491e515a3d8a143e1251c98bd 329 PANTHER PTHR22916 3 269 5.2E-66 T 21-04-2016 SPH21_RS25255 b433958491e515a3d8a143e1251c98bd 329 Pfam PF00535 Glycosyl transferase family 2 4 165 4.9E-26 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS25255 b433958491e515a3d8a143e1251c98bd 329 PANTHER PTHR22916:SF30 3 269 5.2E-66 T 21-04-2016 SPH21_RS25255 b433958491e515a3d8a143e1251c98bd 329 SUPERFAMILY SSF53448 3 269 8.34E-51 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS14420 7b55a807dc103c55761ad69ac3f0091c 360 Gene3D G3DSA:3.60.21.10 64 272 9.3E-14 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS14420 7b55a807dc103c55761ad69ac3f0091c 360 SUPERFAMILY SSF56300 46 311 3.59E-17 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS14420 7b55a807dc103c55761ad69ac3f0091c 360 Pfam PF00149 Calcineurin-like phosphoesterase 59 270 3.3E-9 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS22090 84f92a039ac01ec5d1f6d8d02ba9fd9a 588 Pfam PF14322 Starch-binding associating with outer membrane 76 205 2.3E-19 T 21-04-2016 SPH21_RS22090 84f92a039ac01ec5d1f6d8d02ba9fd9a 588 Gene3D G3DSA:1.25.40.10 184 299 1.4E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22090 84f92a039ac01ec5d1f6d8d02ba9fd9a 588 Gene3D G3DSA:1.25.40.10 384 479 1.4E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22090 84f92a039ac01ec5d1f6d8d02ba9fd9a 588 SUPERFAMILY SSF48452 17 506 4.05E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22090 84f92a039ac01ec5d1f6d8d02ba9fd9a 588 SUPERFAMILY SSF48452 547 579 4.05E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS22090 84f92a039ac01ec5d1f6d8d02ba9fd9a 588 Pfam PF07980 SusD family 258 579 1.4E-55 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS02585 f05cdc5fe890472c76c6468b73d68257 198 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 32 158 1.3E-11 T 21-04-2016 SPH21_RS02585 f05cdc5fe890472c76c6468b73d68257 198 SUPERFAMILY SSF51735 2 193 3.57E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS02585 f05cdc5fe890472c76c6468b73d68257 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 144 2.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02585 f05cdc5fe890472c76c6468b73d68257 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 54 65 2.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02585 f05cdc5fe890472c76c6468b73d68257 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 162 2.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02585 f05cdc5fe890472c76c6468b73d68257 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 2 19 2.3E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS02585 f05cdc5fe890472c76c6468b73d68257 198 Gene3D G3DSA:3.40.50.720 1 197 6.2E-36 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS13925 ec61e3a195c4130cf142492b88bfcb65 269 Gene3D G3DSA:3.40.710.10 23 268 7.7E-67 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS13925 ec61e3a195c4130cf142492b88bfcb65 269 PANTHER PTHR30627:SF6 57 156 6.6E-13 T 21-04-2016 SPH21_RS13925 ec61e3a195c4130cf142492b88bfcb65 269 PANTHER PTHR30627 57 156 6.6E-13 T 21-04-2016 SPH21_RS13925 ec61e3a195c4130cf142492b88bfcb65 269 SUPERFAMILY SSF56601 21 236 7.0E-26 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS13925 ec61e3a195c4130cf142492b88bfcb65 269 ProSitePatterns PS00337 Beta-lactamase class-D active site. 61 71 - T 21-04-2016 IPR002137 Beta-lactamase, class-D active site GO:0008800|GO:0017001 KEGG: 00311+3.5.2.6 SPH21_RS13925 ec61e3a195c4130cf142492b88bfcb65 269 Pfam PF00905 Penicillin binding protein transpeptidase domain 43 262 3.3E-25 T 21-04-2016 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SPH21_RS22475 cf255d9889af41a85a058b0da8a15783 289 Gene3D G3DSA:3.40.50.720 3 222 1.1E-41 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22475 cf255d9889af41a85a058b0da8a15783 289 SUPERFAMILY SSF51735 5 282 3.61E-58 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22475 cf255d9889af41a85a058b0da8a15783 289 PANTHER PTHR14194 6 289 5.6E-92 T 21-04-2016 SPH21_RS22475 cf255d9889af41a85a058b0da8a15783 289 Pfam PF05368 NmrA-like family 7 223 5.0E-32 T 21-04-2016 IPR008030 NmrA-like domain SPH21_RS22475 cf255d9889af41a85a058b0da8a15783 289 PANTHER PTHR14194:SF21 6 289 5.6E-92 T 21-04-2016 SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 Gene3D G3DSA:2.120.10.10 35 390 3.4E-52 T 21-04-2016 IPR011040 Sialidases SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 SUPERFAMILY SSF50939 184 390 5.89E-39 T 21-04-2016 IPR011040 Sialidases SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 SUPERFAMILY SSF50939 38 129 5.89E-39 T 21-04-2016 IPR011040 Sialidases SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 PANTHER PTHR33307 36 112 2.1E-37 T 21-04-2016 SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 PANTHER PTHR33307 154 390 2.1E-37 T 21-04-2016 SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 Pfam PF13088 BNR repeat-like domain 199 367 2.5E-33 T 21-04-2016 IPR011040 Sialidases SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 Pfam PF13088 BNR repeat-like domain 49 128 2.1E-11 T 21-04-2016 IPR011040 Sialidases SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 PANTHER PTHR33307:SF3 36 112 2.1E-37 T 21-04-2016 SPH21_RS09400 13d18222292dcf9474fa3b959a259789 391 PANTHER PTHR33307:SF3 154 390 2.1E-37 T 21-04-2016 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 PANTHER PTHR30173 5 161 1.6E-41 T 21-04-2016 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 8 157 4.2E-33 T 21-04-2016 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 Gene3D G3DSA:1.10.1740.10 4 100 7.9E-30 T 21-04-2016 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 Gene3D G3DSA:1.10.10.10 101 159 3.8E-14 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS16420 f9001d7698559f38968963da814fe267 165 Pfam PF08281 Sigma-70, region 4 105 155 2.5E-13 T 21-04-2016 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 PANTHER PTHR30173:SF8 5 161 1.6E-41 T 21-04-2016 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 SUPERFAMILY SSF88659 94 161 4.36E-12 T 21-04-2016 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 SUPERFAMILY SSF88946 4 87 1.86E-24 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS16420 f9001d7698559f38968963da814fe267 165 Pfam PF04542 Sigma-70 region 2 12 78 4.5E-20 T 21-04-2016 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS10820 e539b57b965bf09eb9459e3e1c34318f 73 PANTHER PTHR33238 1 71 4.5E-18 T 21-04-2016 SPH21_RS10820 e539b57b965bf09eb9459e3e1c34318f 73 SUPERFAMILY SSF50037 6 71 1.72E-17 T 21-04-2016 IPR008988 Transcriptional repressor, C-terminal SPH21_RS10820 e539b57b965bf09eb9459e3e1c34318f 73 SMART SM00899 1 72 1.5E-19 T 21-04-2016 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 SPH21_RS10820 e539b57b965bf09eb9459e3e1c34318f 73 Pfam PF04023 FeoA domain 1 71 1.2E-16 T 21-04-2016 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 SPH21_RS10595 e3819700e7640062ea436678d83a510a 196 PANTHER PTHR11080:SF2 3 196 9.0E-62 T 21-04-2016 SPH21_RS10595 e3819700e7640062ea436678d83a510a 196 PANTHER PTHR11080 3 196 9.0E-62 T 21-04-2016 SPH21_RS10595 e3819700e7640062ea436678d83a510a 196 Gene3D G3DSA:3.40.50.850 2 195 1.7E-57 T 21-04-2016 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SPH21_RS10595 e3819700e7640062ea436678d83a510a 196 SUPERFAMILY SSF52499 2 195 5.23E-43 T 21-04-2016 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SPH21_RS10595 e3819700e7640062ea436678d83a510a 196 Pfam PF00857 Isochorismatase family 3 185 1.7E-26 T 21-04-2016 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SPH21_RS02230 2f497cbe3062e5013e7c119d2fe1bce9 258 Pfam PF06439 Domain of Unknown Function (DUF1080) 42 255 2.5E-40 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS23340 cd6b8c60fd9750c5c90d8d56bff3b962 281 PANTHER PTHR30425 1 280 2.5E-88 T 21-04-2016 SPH21_RS23340 cd6b8c60fd9750c5c90d8d56bff3b962 281 TIGRFAM TIGR00974 3a0107s02c: phosphate ABC transporter, permease protein PstA 12 276 3.6E-87 T 21-04-2016 IPR005672 Phosphate transport system permease protein PstA GO:0005315|GO:0005887|GO:0035435 SPH21_RS23340 cd6b8c60fd9750c5c90d8d56bff3b962 281 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 79 271 3.7E-21 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS23340 cd6b8c60fd9750c5c90d8d56bff3b962 281 Gene3D G3DSA:1.10.3720.10 15 278 1.2E-41 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS23340 cd6b8c60fd9750c5c90d8d56bff3b962 281 SUPERFAMILY SSF161098 27 268 4.45E-36 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 SMART SM00418 6 87 1.6E-19 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 Pfam PF12840 Helix-turn-helix domain 6 61 9.9E-12 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 SUPERFAMILY SSF46785 6 96 4.3E-26 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 8 23 1.5E-10 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 55 70 1.5E-10 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 40 55 1.5E-10 T 21-04-2016 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 PANTHER PTHR33154 6 96 5.6E-22 T 21-04-2016 SPH21_RS04700 2f6b53302c22767caa12c8787e602a26 107 Gene3D G3DSA:1.10.10.10 6 103 4.9E-31 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12255 eecaf64c582d1ee1d930ba69d9138527 61 SUPERFAMILY SSF47598 1 55 1.61E-11 T 21-04-2016 IPR010985 Ribbon-helix-helix GO:0006355 SPH21_RS12255 eecaf64c582d1ee1d930ba69d9138527 61 Gene3D G3DSA:1.10.1220.10 3 57 4.9E-6 T 21-04-2016 IPR013321 Arc-type ribbon-helix-helix GO:0006355 SPH21_RS01225 14fc2d7f36e273454e63ac09e9d1fed3 817 SUPERFAMILY SSF52540 397 747 1.68E-35 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01225 14fc2d7f36e273454e63ac09e9d1fed3 817 Gene3D G3DSA:3.40.50.300 510 527 2.2E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01225 14fc2d7f36e273454e63ac09e9d1fed3 817 Gene3D G3DSA:3.40.50.300 603 721 2.2E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01225 14fc2d7f36e273454e63ac09e9d1fed3 817 Gene3D G3DSA:3.40.50.300 406 475 2.2E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01225 14fc2d7f36e273454e63ac09e9d1fed3 817 PANTHER PTHR38467 1 817 3.7E-186 T 21-04-2016 SPH21_RS01225 14fc2d7f36e273454e63ac09e9d1fed3 817 Pfam PF12991 Domain of unknown function, B. Theta Gene description (DUF3875) 7 50 2.5E-19 T 21-04-2016 IPR024451 Domain of unknown function DUF3875 SPH21_RS01225 14fc2d7f36e273454e63ac09e9d1fed3 817 TIGRFAM TIGR03783 Bac_Flav_CT_G: Bacteroides conjugation system ATPase, TraG family 7 811 0.0 T 21-04-2016 IPR022509 Conjugation system ATPase, TraG SPH21_RS24530 c59315dea4036949784c968068219693 794 PANTHER PTHR30572:SF4 402 794 5.1E-57 T 21-04-2016 SPH21_RS24530 c59315dea4036949784c968068219693 794 PANTHER PTHR30572:SF4 287 356 5.1E-57 T 21-04-2016 SPH21_RS24530 c59315dea4036949784c968068219693 794 Pfam PF12704 MacB-like periplasmic core domain 21 247 2.4E-21 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS24530 c59315dea4036949784c968068219693 794 Pfam PF02687 FtsX-like permease family 290 402 8.2E-16 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS24530 c59315dea4036949784c968068219693 794 Pfam PF02687 FtsX-like permease family 675 786 2.6E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS24530 c59315dea4036949784c968068219693 794 PANTHER PTHR30572 402 794 5.1E-57 T 21-04-2016 SPH21_RS24530 c59315dea4036949784c968068219693 794 PANTHER PTHR30572 287 356 5.1E-57 T 21-04-2016 SPH21_RS25330 6d89f97459c72dd54c2acdc8c4c1ef00 249 Pfam PF00977 Histidine biosynthesis protein 3 233 4.8E-57 T 21-04-2016 IPR006062 Histidine biosynthesis GO:0000105 SPH21_RS25330 6d89f97459c72dd54c2acdc8c4c1ef00 249 Gene3D G3DSA:3.20.20.70 1 241 1.2E-65 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS25330 6d89f97459c72dd54c2acdc8c4c1ef00 249 PANTHER PTHR21235:SF15 1 240 2.4E-70 T 21-04-2016 SPH21_RS25330 6d89f97459c72dd54c2acdc8c4c1ef00 249 SUPERFAMILY SSF51366 1 241 1.08E-56 T 21-04-2016 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SPH21_RS25330 6d89f97459c72dd54c2acdc8c4c1ef00 249 PANTHER PTHR21235 1 240 2.4E-70 T 21-04-2016 SPH21_RS25330 6d89f97459c72dd54c2acdc8c4c1ef00 249 Hamap MF_01014 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase [hisA]. 2 241 28.901 T 21-04-2016 IPR023016 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GO:0000105|GO:0003949 KEGG: 00340+5.3.1.16|UniPathway: UPA00031 SPH21_RS20770 8fc7b0ed165bbd7e5d7d9ebf411cb398 147 PANTHER PTHR33204 1 116 2.9E-19 T 21-04-2016 SPH21_RS20770 8fc7b0ed165bbd7e5d7d9ebf411cb398 147 Gene3D G3DSA:1.10.10.10 6 104 6.9E-22 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20770 8fc7b0ed165bbd7e5d7d9ebf411cb398 147 PANTHER PTHR33204:SF10 1 116 2.9E-19 T 21-04-2016 SPH21_RS20770 8fc7b0ed165bbd7e5d7d9ebf411cb398 147 Pfam PF01638 HxlR-like helix-turn-helix 19 106 8.0E-16 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS20770 8fc7b0ed165bbd7e5d7d9ebf411cb398 147 SUPERFAMILY SSF46785 8 112 5.63E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 PANTHER PTHR30203 5 471 1.4E-98 T 21-04-2016 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 SUPERFAMILY SSF56954 7 470 8.63E-86 T 21-04-2016 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 PANTHER PTHR30203:SF14 5 471 1.4E-98 T 21-04-2016 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 Gene3D G3DSA:2.20.200.10 318 346 1.6E-10 T 21-04-2016 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 Gene3D G3DSA:2.20.200.10 100 145 1.6E-10 T 21-04-2016 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 Pfam PF02321 Outer membrane efflux protein 287 467 1.3E-16 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 Pfam PF02321 Outer membrane efflux protein 66 258 3.9E-25 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 TIGRFAM TIGR01845 outer_NodT: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family 12 469 3.5E-76 T 21-04-2016 IPR010131 RND efflux system, outer membrane lipoprotein, NodT GO:0005215|GO:0006810|GO:0008289|GO:0016020 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 Gene3D G3DSA:1.20.1600.10 52 89 6.1E-89 T 21-04-2016 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 Gene3D G3DSA:1.20.1600.10 356 470 6.1E-89 T 21-04-2016 SPH21_RS24150 780b277f52eb923a23ed4b6c5bddfc98 471 Gene3D G3DSA:1.20.1600.10 146 317 6.1E-89 T 21-04-2016 SPH21_RS23125 f893333196437e00024550fb2fda4ce5 84 Gene3D G3DSA:3.30.1120.10 18 78 9.2E-9 T 21-04-2016 SPH21_RS23125 f893333196437e00024550fb2fda4ce5 84 SUPERFAMILY SSF53649 16 78 9.16E-8 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS04810 c540a44b7b7c6f2831be818fcc362e5a 384 SUPERFAMILY SSF142764 2 378 1.31E-61 T 21-04-2016 SPH21_RS04810 c540a44b7b7c6f2831be818fcc362e5a 384 Pfam PF17042 Putative nucleotide-binding of sugar-metabolising enzyme 267 378 2.1E-7 T 21-04-2016 IPR031475 Putative nucleotide-binding C-terminal domain SPH21_RS04810 c540a44b7b7c6f2831be818fcc362e5a 384 Pfam PF07005 Putative sugar-binding N-terminal domain 2 164 1.7E-35 T 21-04-2016 IPR010737 Putative sugar-binding, N-terminal domain SPH21_RS17530 4a9247d278e42993b8077e79a12e8e63 143 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 19 98 1.3E-7 T 21-04-2016 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SPH21_RS17530 4a9247d278e42993b8077e79a12e8e63 143 SUPERFAMILY SSF52283 2 101 5.95E-13 T 21-04-2016 SPH21_RS17530 4a9247d278e42993b8077e79a12e8e63 143 Gene3D G3DSA:3.40.50.720 1 110 2.9E-16 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00600 699b8b7cb29bb7cc37fe78fe262fd6fc 240 Pfam PF02627 Carboxymuconolactone decarboxylase family 156 216 3.2E-9 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS00600 699b8b7cb29bb7cc37fe78fe262fd6fc 240 Pfam PF02627 Carboxymuconolactone decarboxylase family 27 90 2.2E-7 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS00600 699b8b7cb29bb7cc37fe78fe262fd6fc 240 PANTHER PTHR33570 31 214 4.0E-13 T 21-04-2016 SPH21_RS00600 699b8b7cb29bb7cc37fe78fe262fd6fc 240 Gene3D G3DSA:1.20.1290.10 23 135 9.6E-15 T 21-04-2016 IPR029032 AhpD-like SPH21_RS00600 699b8b7cb29bb7cc37fe78fe262fd6fc 240 Gene3D G3DSA:1.20.1290.10 148 237 3.4E-10 T 21-04-2016 IPR029032 AhpD-like SPH21_RS00600 699b8b7cb29bb7cc37fe78fe262fd6fc 240 SUPERFAMILY SSF69118 25 238 2.73E-45 T 21-04-2016 IPR029032 AhpD-like SPH21_RS00600 699b8b7cb29bb7cc37fe78fe262fd6fc 240 PANTHER PTHR33570:SF4 31 214 4.0E-13 T 21-04-2016 SPH21_RS02695 a0a96bedb87ff9beee2d3fa4dc98e864 292 PIRSF PIRSF003097 5 285 9.2E-66 T 21-04-2016 IPR004513 Cell division protein FtsX GO:0007049|GO:0016021 SPH21_RS02695 a0a96bedb87ff9beee2d3fa4dc98e864 292 Pfam PF02687 FtsX-like permease family 170 278 1.3E-8 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS07830 247bf780f404b8e36d1c026135c7ec0e 168 Pfam PF02472 Biopolymer transport protein ExbD/TolR 9 150 4.1E-24 T 21-04-2016 IPR003400 Biopolymer transport protein ExbD/TolR GO:0005215|GO:0006810|GO:0016020 SPH21_RS26335 696c619c594acaca436f89ac0ece644c 256 Pfam PF08843 Nucleotidyl transferase AbiEii toxin, Type IV TA system 25 214 7.9E-9 T 21-04-2016 IPR014942 Nucleotidyl transferase AbiEii toxin, Type IV TA system SPH21_RS24675 58a5003f4b12cfb861180ae4156be898 169 SUPERFAMILY SSF53597 1 162 3.23E-13 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS24675 58a5003f4b12cfb861180ae4156be898 169 Gene3D G3DSA:3.40.430.10 1 159 8.6E-11 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS05105 6c334f63b2b72accd98deecc3e83493f 258 SUPERFAMILY SSF53633 2 257 1.54E-48 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS05105 6c334f63b2b72accd98deecc3e83493f 258 TIGRFAM TIGR00761 argB: acetylglutamate kinase 6 242 2.8E-54 T 21-04-2016 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS05105 6c334f63b2b72accd98deecc3e83493f 258 Pfam PF00696 Amino acid kinase family 4 243 3.8E-33 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS05105 6c334f63b2b72accd98deecc3e83493f 258 PANTHER PTHR23342 2 242 4.1E-55 T 21-04-2016 SPH21_RS05105 6c334f63b2b72accd98deecc3e83493f 258 Gene3D G3DSA:3.40.1160.10 2 257 5.3E-67 T 21-04-2016 IPR001048 Aspartate/glutamate/uridylate kinase Reactome: REACT_13 SPH21_RS05105 6c334f63b2b72accd98deecc3e83493f 258 PIRSF PIRSF000728 1 258 6.5E-66 T 21-04-2016 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400|UniPathway: UPA00068 SPH21_RS21190 c53b1651cf1267c163d2ae09e90768a9 157 PANTHER PTHR12302 9 154 1.5E-35 T 21-04-2016 SPH21_RS21190 c53b1651cf1267c163d2ae09e90768a9 157 Gene3D G3DSA:2.40.50.90 21 149 1.9E-33 T 21-04-2016 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold SPH21_RS21190 c53b1651cf1267c163d2ae09e90768a9 157 SMART SM00318 21 143 1.6E-35 T 21-04-2016 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold SPH21_RS21190 c53b1651cf1267c163d2ae09e90768a9 157 ProSitePatterns PS01123 Thermonuclease family signature 1. 32 57 - T 21-04-2016 IPR002071 Thermonuclease active site GO:0003676|GO:0004518 SPH21_RS21190 c53b1651cf1267c163d2ae09e90768a9 157 SUPERFAMILY SSF50199 18 150 1.7E-37 T 21-04-2016 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold SPH21_RS21190 c53b1651cf1267c163d2ae09e90768a9 157 Pfam PF00565 Staphylococcal nuclease homologue 47 142 6.9E-24 T 21-04-2016 IPR016071 Staphylococcal nuclease (SNase-like), OB-fold SPH21_RS17085 79bc805e8f68519a339662c3b517c71b 980 PANTHER PTHR32294 1 925 2.1E-173 T 21-04-2016 SPH21_RS17085 79bc805e8f68519a339662c3b517c71b 980 Pfam PF02811 PHP domain 3 125 1.0E-9 T 21-04-2016 IPR004013 PHP domain GO:0003824 SPH21_RS17085 79bc805e8f68519a339662c3b517c71b 980 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 149 926 8.1E-141 T 21-04-2016 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS17085 79bc805e8f68519a339662c3b517c71b 980 Pfam PF14579 Helix-hairpin-helix motif 728 813 3.3E-18 T 21-04-2016 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS17085 79bc805e8f68519a339662c3b517c71b 980 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 247 653 1.2E-105 T 21-04-2016 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SPH21_RS03300 602d8bdc26b683fd2a6cdfe626d4649d 378 SUPERFAMILY SSF56796 3 377 4.97E-112 T 21-04-2016 SPH21_RS03300 602d8bdc26b683fd2a6cdfe626d4649d 378 PANTHER PTHR11496 1 378 4.3E-100 T 21-04-2016 SPH21_RS03300 602d8bdc26b683fd2a6cdfe626d4649d 378 ProSitePatterns PS00060 Iron-containing alcohol dehydrogenases signature 2. 261 281 - T 21-04-2016 IPR018211 Alcohol dehydrogenase, iron-type, conserved site GO:0016491|GO:0046872|GO:0055114 SPH21_RS03300 602d8bdc26b683fd2a6cdfe626d4649d 378 Gene3D G3DSA:1.20.1090.10 188 378 2.6E-59 T 21-04-2016 SPH21_RS03300 602d8bdc26b683fd2a6cdfe626d4649d 378 Gene3D G3DSA:3.40.50.1970 3 187 1.2E-48 T 21-04-2016 SPH21_RS03300 602d8bdc26b683fd2a6cdfe626d4649d 378 ProSitePatterns PS00913 Iron-containing alcohol dehydrogenases signature 1. 176 204 - T 21-04-2016 IPR018211 Alcohol dehydrogenase, iron-type, conserved site GO:0016491|GO:0046872|GO:0055114 SPH21_RS03300 602d8bdc26b683fd2a6cdfe626d4649d 378 Pfam PF00465 Iron-containing alcohol dehydrogenase 8 369 9.1E-108 T 21-04-2016 IPR001670 Alcohol dehydrogenase, iron-type GO:0016491|GO:0046872|GO:0055114 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 Pfam PF13180 PDZ domain 161 215 2.4E-6 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 PANTHER PTHR32060 366 416 7.1E-19 T 21-04-2016 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 PANTHER PTHR32060 155 328 7.1E-19 T 21-04-2016 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 PANTHER PTHR32060:SF0 366 416 7.1E-19 T 21-04-2016 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 PANTHER PTHR32060:SF0 155 328 7.1E-19 T 21-04-2016 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 SUPERFAMILY SSF50156 137 212 2.63E-8 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 Gene3D G3DSA:3.90.226.10 355 466 1.8E-34 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 Gene3D G3DSA:3.90.226.10 227 314 1.8E-34 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 Gene3D G3DSA:2.30.42.10 152 194 6.0E-8 T 21-04-2016 IPR001478 PDZ domain GO:0005515 SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 SUPERFAMILY SSF52096 198 338 1.82E-30 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 SUPERFAMILY SSF52096 374 464 1.82E-30 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS26350 a16a453da548e9fa563eca21eece9c00 539 Pfam PF03572 Peptidase family S41 251 441 1.4E-19 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 SMART SM00411 1 90 2.0E-39 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 PRINTS PR01727 Prokaryotic integration host factor signature 40 55 1.6E-17 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 PRINTS PR01727 Prokaryotic integration host factor signature 74 88 1.6E-17 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 PRINTS PR01727 Prokaryotic integration host factor signature 58 71 1.6E-17 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 Pfam PF00216 Bacterial DNA-binding protein 1 89 3.5E-32 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature. 46 65 - T 21-04-2016 IPR020816 Histone-like DNA-binding protein, conserved site GO:0003677 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 Gene3D G3DSA:4.10.520.10 1 93 4.5E-36 T 21-04-2016 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 PANTHER PTHR33175 1 89 5.8E-37 T 21-04-2016 SPH21_RS10370 f920db134bf98b2bdd2653c2322ca92d 96 SUPERFAMILY SSF47729 1 91 1.41E-30 T 21-04-2016 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SPH21_RS06160 eafbb078bbf994aa7d85f075b6e877e6 330 Gene3D G3DSA:2.120.10.30 45 328 3.7E-56 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS06160 eafbb078bbf994aa7d85f075b6e877e6 330 PANTHER PTHR10907 32 329 1.3E-81 T 21-04-2016 SPH21_RS06160 eafbb078bbf994aa7d85f075b6e877e6 330 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 58 321 1.2E-43 T 21-04-2016 IPR013658 SMP-30/Gluconolactonase/LRE-like region SPH21_RS06160 eafbb078bbf994aa7d85f075b6e877e6 330 SUPERFAMILY SSF63829 35 329 8.72E-52 T 21-04-2016 SPH21_RS06160 eafbb078bbf994aa7d85f075b6e877e6 330 PANTHER PTHR10907:SF65 32 329 1.3E-81 T 21-04-2016 SPH21_RS04440 bad2832034d239a6b1f85687e091160e 232 PANTHER PTHR11019 1 68 1.8E-62 T 21-04-2016 SPH21_RS04440 bad2832034d239a6b1f85687e091160e 232 PANTHER PTHR11019 89 228 1.8E-62 T 21-04-2016 SPH21_RS04440 bad2832034d239a6b1f85687e091160e 232 SUPERFAMILY SSF52317 6 229 4.17E-81 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS04440 bad2832034d239a6b1f85687e091160e 232 Pfam PF01965 DJ-1/PfpI family 31 226 1.5E-19 T 21-04-2016 IPR002818 DJ-1/PfpI SPH21_RS04440 bad2832034d239a6b1f85687e091160e 232 PANTHER PTHR11019:SF97 1 68 1.8E-62 T 21-04-2016 SPH21_RS04440 bad2832034d239a6b1f85687e091160e 232 PANTHER PTHR11019:SF97 89 228 1.8E-62 T 21-04-2016 SPH21_RS04440 bad2832034d239a6b1f85687e091160e 232 Gene3D G3DSA:3.40.50.880 7 231 8.0E-94 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS20000 e2ee67168dfbe7535b7cd301b82464cb 261 Pfam PF09697 Protein of unknown function (Porph_ging) 167 197 1.2E-9 T 21-04-2016 IPR005901 GLPGLI family protein SPH21_RS20000 e2ee67168dfbe7535b7cd301b82464cb 261 TIGRFAM TIGR01200 GLPGLI: GLPGLI family protein 11 242 3.0E-44 T 21-04-2016 IPR005901 GLPGLI family protein SPH21_RS11555 fd296b0bb5439ba17739ffe13977865a 392 Pfam PF13416 Bacterial extracellular solute-binding protein 4 315 2.0E-21 T 21-04-2016 SPH21_RS11555 fd296b0bb5439ba17739ffe13977865a 392 Gene3D G3DSA:3.40.190.10 106 325 1.3E-40 T 21-04-2016 SPH21_RS11555 fd296b0bb5439ba17739ffe13977865a 392 PANTHER PTHR30061 1 387 8.9E-41 T 21-04-2016 SPH21_RS11555 fd296b0bb5439ba17739ffe13977865a 392 SUPERFAMILY SSF53850 1 387 2.72E-49 T 21-04-2016 SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 PANTHER PTHR12725 3 200 1.3E-29 T 21-04-2016 SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 5 183 3.3E-16 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 Pfam PF13419 Haloacid dehalogenase-like hydrolase 5 183 3.5E-19 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 PANTHER PTHR12725:SF63 3 200 1.3E-29 T 21-04-2016 SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 SUPERFAMILY SSF56784 3 195 8.94E-39 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 Gene3D G3DSA:3.40.50.1000 1 195 8.7E-41 T 21-04-2016 IPR023214 HAD-like domain SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 174 187 7.9E-10 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 2 13 7.9E-10 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 147 167 7.9E-10 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS08645 153b24afa88f73cf59357117377d42e9 201 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 129 145 7.9E-10 T 21-04-2016 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SPH21_RS21075 bd4ad25ae92b5a35b484aa45654f1ffc 359 SUPERFAMILY SSF56935 23 355 4.21E-6 T 21-04-2016 SPH21_RS21075 bd4ad25ae92b5a35b484aa45654f1ffc 359 Pfam PF07642 Putative beta-barrel porin-2, OmpL-like. bbp2 27 359 1.3E-96 T 21-04-2016 IPR011486 Putative beta-barrel porin-2, OmpL-like. bbp2 SPH21_RS23465 32e30706ff5c1773cfdfc237528c7808 208 Gene3D G3DSA:3.40.30.10 52 208 2.5E-37 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS23465 32e30706ff5c1773cfdfc237528c7808 208 PANTHER PTHR10681 46 208 2.3E-14 T 21-04-2016 SPH21_RS23465 32e30706ff5c1773cfdfc237528c7808 208 SUPERFAMILY SSF52833 53 206 1.42E-29 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS23465 32e30706ff5c1773cfdfc237528c7808 208 PANTHER PTHR10681:SF68 46 208 2.3E-14 T 21-04-2016 SPH21_RS23465 32e30706ff5c1773cfdfc237528c7808 208 ProSitePatterns PS00194 Thioredoxin family active site. 97 115 - T 21-04-2016 IPR017937 Thioredoxin, conserved site GO:0045454 SPH21_RS23465 32e30706ff5c1773cfdfc237528c7808 208 Pfam PF08534 Redoxin 74 192 2.0E-14 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS23805 0cc662f76d18efc39e1ac1ebb5c6417a 256 PANTHER PTHR31118 63 255 1.3E-30 T 21-04-2016 SPH21_RS23805 0cc662f76d18efc39e1ac1ebb5c6417a 256 Pfam PF04199 Putative cyclase 6 184 6.5E-37 T 21-04-2016 IPR007325 Kynurenine formamidase GO:0004061|GO:0019441 KEGG: 00380+3.5.1.9|KEGG: 00630+3.5.1.9|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-7717|MetaCyc: PWY-7733|MetaCyc: PWY-7734|UniPathway: UPA00333 SPH21_RS23805 0cc662f76d18efc39e1ac1ebb5c6417a 256 Gene3D G3DSA:3.50.30.50 2 255 2.3E-58 T 21-04-2016 SPH21_RS23805 0cc662f76d18efc39e1ac1ebb5c6417a 256 SUPERFAMILY SSF102198 2 255 9.55E-52 T 21-04-2016 SPH21_RS16585 19877f3c9b805b84b97ea455857a542f 488 SUPERFAMILY SSF52266 145 182 1.22E-23 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16585 19877f3c9b805b84b97ea455857a542f 488 SUPERFAMILY SSF52266 317 474 1.22E-23 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16585 19877f3c9b805b84b97ea455857a542f 488 Gene3D G3DSA:3.40.50.1110 146 178 5.5E-20 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16585 19877f3c9b805b84b97ea455857a542f 488 Gene3D G3DSA:3.40.50.1110 306 478 5.5E-20 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS16585 19877f3c9b805b84b97ea455857a542f 488 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 312 462 5.5E-7 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 Pfam PF11028 Protein of unknown function (DUF2723) 36 215 7.1E-66 T 21-04-2016 IPR021280 Protein of unknown function DUF2723 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214:SF2 299 345 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214:SF2 548 671 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214:SF2 3 230 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214:SF2 409 532 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214:SF2 755 1008 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214 299 345 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214 548 671 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214 3 230 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214 409 532 2.4E-180 T 21-04-2016 SPH21_RS25545 9c9e3e7d9fa1fa65606cae79527ecff6 1008 PANTHER PTHR16214 755 1008 2.4E-180 T 21-04-2016 SPH21_RS06510 6d29cf1cbdfe966a8df2ee5ca47e9f42 597 Pfam PF00723 Glycosyl hydrolases family 15 216 527 4.0E-30 T 21-04-2016 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: REACT_474 SPH21_RS06510 6d29cf1cbdfe966a8df2ee5ca47e9f42 597 SUPERFAMILY SSF48208 202 587 6.8E-81 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS06510 6d29cf1cbdfe966a8df2ee5ca47e9f42 597 Gene3D G3DSA:1.50.10.10 216 586 2.2E-71 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS06510 6d29cf1cbdfe966a8df2ee5ca47e9f42 597 PANTHER PTHR31616 7 597 7.0E-120 T 21-04-2016 SPH21_RS06510 6d29cf1cbdfe966a8df2ee5ca47e9f42 597 PANTHER PTHR31616:SF0 7 597 7.0E-120 T 21-04-2016 SPH21_RS10015 6d8036c2ea473f5fe5a7c30b47279799 338 Pfam PF11790 Glycosyl hydrolase catalytic core 195 295 2.1E-7 T 21-04-2016 IPR024655 Uncharacterised protein family, glycosyl hydrolase catalytic domain SPH21_RS10015 6d8036c2ea473f5fe5a7c30b47279799 338 SUPERFAMILY SSF51445 34 336 1.82E-29 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS10015 6d8036c2ea473f5fe5a7c30b47279799 338 Gene3D G3DSA:3.20.20.80 36 336 1.0E-23 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS23695 444113880eb0f87f009c4faab8f5071e 286 Pfam PF13557 Putative MetA-pathway of phenol degradation 52 277 1.3E-22 T 21-04-2016 IPR025737 MetA-pathway of phenol degradation, putative SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 Gene3D G3DSA:3.40.50.720 1 254 1.2E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 SUPERFAMILY SSF51735 3 254 5.53E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 11 254 1.8E-34 T 21-04-2016 SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 6 23 3.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 91 3.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 3.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 3.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS22215 43da081c7e66f11c6f43475c38d209cc 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 3.8E-9 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS01325 7beff262bd9ac8a5a5580dcf99f95af7 670 Pfam PF02534 Type IV secretory system Conjugative DNA transfer 161 555 1.6E-20 T 21-04-2016 IPR003688 Type IV secretion system protein TraG/VirD4 GO:0009291|GO:0016020 SPH21_RS01325 7beff262bd9ac8a5a5580dcf99f95af7 670 Gene3D G3DSA:3.40.50.300 406 581 7.0E-30 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01325 7beff262bd9ac8a5a5580dcf99f95af7 670 Gene3D G3DSA:3.40.50.300 193 284 7.0E-30 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01325 7beff262bd9ac8a5a5580dcf99f95af7 670 SUPERFAMILY SSF52540 186 585 2.44E-37 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS01325 7beff262bd9ac8a5a5580dcf99f95af7 670 Pfam PF14293 YWFCY protein 2 60 5.9E-27 T 21-04-2016 IPR025988 YWFCY domain SPH21_RS19950 271ba88d406478b25d21e405633bb634 235 PANTHER PTHR15362 5 141 6.4E-21 T 21-04-2016 SPH21_RS19950 271ba88d406478b25d21e405633bb634 235 Pfam PF01066 CDP-alcohol phosphatidyltransferase 5 68 9.3E-15 T 21-04-2016 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SPH21_RS19950 271ba88d406478b25d21e405633bb634 235 PANTHER PTHR15362:SF2 5 141 6.4E-21 T 21-04-2016 SPH21_RS19950 271ba88d406478b25d21e405633bb634 235 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 46 68 - T 21-04-2016 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SPH21_RS04675 5b446aa84648ade7d89368be950a9a43 397 Pfam PF07690 Major Facilitator Superfamily 13 231 8.2E-24 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS04675 5b446aa84648ade7d89368be950a9a43 397 PANTHER PTHR23502 8 385 2.3E-67 T 21-04-2016 SPH21_RS04675 5b446aa84648ade7d89368be950a9a43 397 PANTHER PTHR23502:SF19 8 385 2.3E-67 T 21-04-2016 SPH21_RS04675 5b446aa84648ade7d89368be950a9a43 397 Gene3D G3DSA:1.20.1250.20 11 189 1.2E-18 T 21-04-2016 SPH21_RS04675 5b446aa84648ade7d89368be950a9a43 397 Gene3D G3DSA:1.20.1250.20 212 386 5.7E-6 T 21-04-2016 SPH21_RS04675 5b446aa84648ade7d89368be950a9a43 397 SUPERFAMILY SSF103473 9 388 1.57E-43 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 PANTHER PTHR10996 1 315 3.8E-102 T 21-04-2016 SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 8 315 3.0E-33 T 21-04-2016 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 112 291 4.2E-42 T 21-04-2016 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 PANTHER PTHR10996:SF20 1 315 3.8E-102 T 21-04-2016 SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 Gene3D G3DSA:3.40.50.720 106 294 1.9E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 SUPERFAMILY SSF51735 96 292 6.95E-43 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 SUPERFAMILY SSF52283 1 119 7.94E-29 T 21-04-2016 SPH21_RS15380 e42e7a10b00571acd024896db44e6aba 315 Gene3D G3DSA:3.40.50.720 1 105 1.8E-34 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS25425 bd8eb38aa253801327d874801ec95235 155 Pfam PF01503 Phosphoribosyl-ATP pyrophosphohydrolase 10 94 2.2E-22 T 21-04-2016 IPR021130 Phosphoribosyl-ATP pyrophosphohydrolase-like KEGG: 00340+3.6.1.31|UniPathway: UPA00031 SPH21_RS25425 bd8eb38aa253801327d874801ec95235 155 Gene3D G3DSA:1.10.3420.10 6 154 9.0E-41 T 21-04-2016 IPR023292 NTP pyrophosphohydrolase-like domain SPH21_RS13675 ec419a8cc20da781bb28e908e229f1e8 371 Pfam PF16398 Domain of unknown function (DUF5007) 70 370 2.1E-129 T 21-04-2016 IPR032173 Protein of unknown function DUF5007 SPH21_RS10040 bd3a814f786e46cf49b0f0cedfcfb298 358 Pfam PF13480 Acetyltransferase (GNAT) domain 170 300 4.4E-10 T 21-04-2016 SPH21_RS10040 bd3a814f786e46cf49b0f0cedfcfb298 358 SUPERFAMILY SSF55729 162 326 1.95E-25 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS10040 bd3a814f786e46cf49b0f0cedfcfb298 358 Gene3D G3DSA:3.40.630.30 154 318 8.8E-22 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 PANTHER PTHR11986 28 443 1.1E-115 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 TIGRFAM TIGR03251 LAT_fam: L-lysine 6-transaminase 9 440 9.4E-193 T 21-04-2016 IPR017657 L-lysine 6-transaminase GO:0017000|GO:0030170|GO:0045484 MetaCyc: PWY-5298 SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 PIRSF PIRSF000521 3 443 7.0E-138 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 Gene3D G3DSA:3.40.640.10 94 335 4.3E-61 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 Gene3D G3DSA:3.90.1150.10 336 442 3.5E-27 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 PANTHER PTHR11986:SF7 28 443 1.1E-115 T 21-04-2016 SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 Pfam PF00202 Aminotransferase class-III 26 440 6.2E-87 T 21-04-2016 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SPH21_RS18320 02a60bf6fd3be9b26a5c5fec638f41a8 443 SUPERFAMILY SSF53383 27 441 3.83E-80 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS03355 5ea9ee6c2c33c192faaef7a31c04e7b2 418 SUPERFAMILY SSF50952 72 415 7.06E-35 T 21-04-2016 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SPH21_RS03355 5ea9ee6c2c33c192faaef7a31c04e7b2 418 Pfam PF07995 Glucose / Sorbosone dehydrogenase 182 299 2.1E-11 T 21-04-2016 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SPH21_RS03355 5ea9ee6c2c33c192faaef7a31c04e7b2 418 Gene3D G3DSA:2.120.10.30 70 417 3.0E-58 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS03355 5ea9ee6c2c33c192faaef7a31c04e7b2 418 PANTHER PTHR19328:SF26 57 417 6.5E-144 T 21-04-2016 SPH21_RS03355 5ea9ee6c2c33c192faaef7a31c04e7b2 418 PANTHER PTHR19328 57 417 6.5E-144 T 21-04-2016 SPH21_RS17150 b27229741ab1a254e0918f4edea55518 293 Pfam PF00924 Mechanosensitive ion channel 97 271 2.1E-31 T 21-04-2016 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SPH21_RS17150 b27229741ab1a254e0918f4edea55518 293 Gene3D G3DSA:2.30.30.60 157 203 4.8E-10 T 21-04-2016 SPH21_RS17150 b27229741ab1a254e0918f4edea55518 293 PANTHER PTHR30566 92 239 2.7E-17 T 21-04-2016 SPH21_RS17150 b27229741ab1a254e0918f4edea55518 293 SUPERFAMILY SSF50182 139 205 5.89E-13 T 21-04-2016 IPR010920 LSM domain SPH21_RS07550 0febe629a8f6e019005437f4ba35fc17 378 Gene3D G3DSA:2.130.10.10 95 344 5.4E-4 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS07550 0febe629a8f6e019005437f4ba35fc17 378 SUPERFAMILY SSF63825 89 158 2.14E-5 T 21-04-2016 SPH21_RS07550 0febe629a8f6e019005437f4ba35fc17 378 SUPERFAMILY SSF63825 213 342 2.14E-5 T 21-04-2016 SPH21_RS10645 03d32f41f6843e57122e64fd80fa5720 462 Pfam PF07005 Putative sugar-binding N-terminal domain 7 249 4.2E-53 T 21-04-2016 IPR010737 Putative sugar-binding, N-terminal domain SPH21_RS10645 03d32f41f6843e57122e64fd80fa5720 462 PANTHER PTHR30304 159 454 1.3E-18 T 21-04-2016 SPH21_RS10645 03d32f41f6843e57122e64fd80fa5720 462 SUPERFAMILY SSF142764 7 458 1.96E-94 T 21-04-2016 SPH21_RS10645 03d32f41f6843e57122e64fd80fa5720 462 Pfam PF17042 Putative nucleotide-binding of sugar-metabolising enzyme 276 453 7.5E-37 T 21-04-2016 IPR031475 Putative nucleotide-binding C-terminal domain SPH21_RS10645 03d32f41f6843e57122e64fd80fa5720 462 PANTHER PTHR30304:SF3 159 454 1.3E-18 T 21-04-2016 SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 Gene3D G3DSA:1.10.486.10 487 612 8.5E-10 T 21-04-2016 SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 PANTHER PTHR11070:SF3 2 716 1.6E-162 T 21-04-2016 SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 Gene3D G3DSA:3.40.50.300 272 372 1.0E-68 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 Gene3D G3DSA:3.40.50.300 99 239 1.0E-68 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 PANTHER PTHR11070 2 716 1.6E-162 T 21-04-2016 IPR000212 DNA helicase, UvrD/REP type GO:0003677|GO:0004003|GO:0005524 SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 SUPERFAMILY SSF52540 96 722 7.81E-132 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 Gene3D G3DSA:3.40.50.300 636 725 1.2E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 Gene3D G3DSA:3.40.50.300 379 486 1.2E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 Pfam PF13361 UvrD-like helicase C-terminal domain 376 698 4.4E-48 T 21-04-2016 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SPH21_RS19070 e15bb98b537820330003ab93cdc15d9e 729 Pfam PF00580 UvrD/REP helicase N-terminal domain 100 369 2.4E-65 T 21-04-2016 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SPH21_RS16870 2aa86824fb19a853f0c37348d5755f2c 422 SUPERFAMILY SSF56601 72 182 3.27E-17 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS16870 2aa86824fb19a853f0c37348d5755f2c 422 SUPERFAMILY SSF56601 237 267 3.27E-17 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS16870 2aa86824fb19a853f0c37348d5755f2c 422 SUPERFAMILY SSF56601 305 367 3.27E-17 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS16870 2aa86824fb19a853f0c37348d5755f2c 422 Pfam PF13354 Beta-lactamase enzyme family 71 231 4.2E-11 T 21-04-2016 SPH21_RS16870 2aa86824fb19a853f0c37348d5755f2c 422 Gene3D G3DSA:3.40.710.10 248 401 1.5E-32 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS16870 2aa86824fb19a853f0c37348d5755f2c 422 Gene3D G3DSA:3.40.710.10 30 180 1.5E-32 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 Pfam PF12833 Helix-turn-helix domain 225 301 5.0E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 PANTHER PTHR11019:SF50 23 303 6.3E-31 T 21-04-2016 SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 PANTHER PTHR11019 23 303 6.3E-31 T 21-04-2016 SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 SMART SM00342 217 300 2.9E-17 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 SUPERFAMILY SSF46689 255 303 5.38E-11 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 Gene3D G3DSA:1.10.10.60 256 302 5.2E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 269 284 7.76E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS21480 4283f3e1df8354d2ada7b5d9665d6d66 307 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 284 300 7.76E-5 T 21-04-2016 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 SUPERFAMILY SSF82171 31 437 1.44E-56 T 21-04-2016 SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 SUPERFAMILY SSF53474 468 723 9.22E-62 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 Gene3D G3DSA:2.140.10.30 28 452 3.7E-107 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 Gene3D G3DSA:3.40.50.1820 468 723 1.1E-72 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 PANTHER PTHR11731 20 721 3.0E-186 T 21-04-2016 SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 PANTHER PTHR11731:SF110 20 721 3.0E-186 T 21-04-2016 SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 Pfam PF00326 Prolyl oligopeptidase family 528 722 2.0E-41 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS04875 465b8c5e941e55937c0c19889b35d22c 728 Pfam PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region 85 436 6.3E-87 T 21-04-2016 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SPH21_RS17465 53a5d7e3901e0474b480806f777827d1 384 SUPERFAMILY SSF48230 44 342 1.74E-50 T 21-04-2016 IPR008929 Chondroitin AC/alginate lyase SPH21_RS17465 53a5d7e3901e0474b480806f777827d1 384 Gene3D G3DSA:1.50.10.110 19 368 7.2E-66 T 21-04-2016 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SPH21_RS17465 53a5d7e3901e0474b480806f777827d1 384 Pfam PF05426 Alginate lyase 37 316 9.2E-71 T 21-04-2016 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SPH21_RS17465 53a5d7e3901e0474b480806f777827d1 384 PANTHER PTHR41379 18 321 5.3E-76 T 21-04-2016 SPH21_RS17465 53a5d7e3901e0474b480806f777827d1 384 PANTHER PTHR41379:SF1 18 321 5.3E-76 T 21-04-2016 SPH21_RS21660 c2a63ed8e31fbbdff42c1f9021407157 338 Pfam PF06580 Histidine kinase 159 237 1.3E-23 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS21660 c2a63ed8e31fbbdff42c1f9021407157 338 PANTHER PTHR34220 9 338 2.8E-45 T 21-04-2016 SPH21_RS06350 a7212bb59ec6ed54b8ff592d683e8ba0 317 PANTHER PTHR23088 1 182 3.7E-44 T 21-04-2016 SPH21_RS06350 a7212bb59ec6ed54b8ff592d683e8ba0 317 PANTHER PTHR23088 214 282 3.7E-44 T 21-04-2016 SPH21_RS06350 a7212bb59ec6ed54b8ff592d683e8ba0 317 Pfam PF00795 Carbon-nitrogen hydrolase 5 280 1.6E-37 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS06350 a7212bb59ec6ed54b8ff592d683e8ba0 317 SUPERFAMILY SSF56317 212 280 1.44E-52 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS06350 a7212bb59ec6ed54b8ff592d683e8ba0 317 SUPERFAMILY SSF56317 1 179 1.44E-52 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS06350 a7212bb59ec6ed54b8ff592d683e8ba0 317 Gene3D G3DSA:3.60.110.10 1 299 6.2E-58 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS02305 04776fb716af0b8ab4c658f9db28ff02 385 Gene3D G3DSA:1.50.10.10 31 383 1.1E-89 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS02305 04776fb716af0b8ab4c658f9db28ff02 385 PANTHER PTHR33886:SF2 58 385 1.1E-90 T 21-04-2016 SPH21_RS02305 04776fb716af0b8ab4c658f9db28ff02 385 Pfam PF07470 Glycosyl Hydrolase Family 88 44 381 7.6E-81 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS02305 04776fb716af0b8ab4c658f9db28ff02 385 SUPERFAMILY SSF48208 46 383 3.06E-47 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02305 04776fb716af0b8ab4c658f9db28ff02 385 PANTHER PTHR33886 58 385 1.1E-90 T 21-04-2016 SPH21_RS03575 8ab60ff12764fd7573422e255615cf7c 287 Gene3D G3DSA:3.30.420.40 149 265 9.0E-13 T 21-04-2016 SPH21_RS03575 8ab60ff12764fd7573422e255615cf7c 287 SUPERFAMILY SSF53067 5 285 3.57E-36 T 21-04-2016 SPH21_RS03575 8ab60ff12764fd7573422e255615cf7c 287 PANTHER PTHR18964 4 283 1.2E-19 T 21-04-2016 SPH21_RS03575 8ab60ff12764fd7573422e255615cf7c 287 Gene3D G3DSA:3.30.420.40 3 148 1.4E-24 T 21-04-2016 SPH21_RS03575 8ab60ff12764fd7573422e255615cf7c 287 Pfam PF00480 ROK family 172 286 8.7E-8 T 21-04-2016 IPR000600 ROK family SPH21_RS03575 8ab60ff12764fd7573422e255615cf7c 287 Pfam PF00480 ROK family 7 162 6.9E-14 T 21-04-2016 IPR000600 ROK family SPH21_RS03575 8ab60ff12764fd7573422e255615cf7c 287 PANTHER PTHR18964:SF121 4 283 1.2E-19 T 21-04-2016 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 Gene3D G3DSA:3.40.50.1820 424 676 4.4E-67 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 PANTHER PTHR11731:SF150 94 676 4.8E-114 T 21-04-2016 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 SUPERFAMILY SSF82171 26 140 1.7E-35 T 21-04-2016 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 SUPERFAMILY SSF82171 200 412 1.7E-35 T 21-04-2016 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 Pfam PF00326 Prolyl oligopeptidase family 468 676 1.5E-50 T 21-04-2016 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 PANTHER PTHR11731 94 676 4.8E-114 T 21-04-2016 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 Gene3D G3DSA:2.130.10.10 204 409 1.8E-25 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 Gene3D G3DSA:2.130.10.10 17 163 7.9E-15 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS08660 73598490d20d285088a755ae1fbf076b 676 SUPERFAMILY SSF53474 424 676 2.08E-64 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS23110 77d715e69a7438f8d572b65bb9fda58d 111 SUPERFAMILY SSF55785 9 81 6.28E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS23110 77d715e69a7438f8d572b65bb9fda58d 111 Gene3D G3DSA:3.30.450.20 10 82 5.6E-7 T 21-04-2016 SPH21_RS23110 77d715e69a7438f8d572b65bb9fda58d 111 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 9 82 1.5E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS23045 c3ee9d5887a63d9e46f2f2d7c4d0879c 258 Gene3D G3DSA:3.90.640.20 162 249 5.9E-22 T 21-04-2016 IPR021729 Domain of unknown function DUF3298 SPH21_RS23045 c3ee9d5887a63d9e46f2f2d7c4d0879c 258 Gene3D G3DSA:3.30.565.40 34 145 4.6E-17 T 21-04-2016 IPR025303 Domain of unknown function DUF4163 SPH21_RS23045 c3ee9d5887a63d9e46f2f2d7c4d0879c 258 Pfam PF11738 Protein of unknown function (DUF3298) 56 234 3.1E-10 T 21-04-2016 IPR021729 Domain of unknown function DUF3298 SPH21_RS23045 c3ee9d5887a63d9e46f2f2d7c4d0879c 258 Pfam PF13739 Domain of unknown function (DUF4163) 41 137 9.2E-12 T 21-04-2016 IPR025303 Domain of unknown function DUF4163 SPH21_RS21445 e36981cee2bd1dd02d56266a05c4b00c 566 Gene3D G3DSA:1.25.40.10 368 465 8.6E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21445 e36981cee2bd1dd02d56266a05c4b00c 566 Gene3D G3DSA:1.25.40.10 193 292 8.6E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21445 e36981cee2bd1dd02d56266a05c4b00c 566 Pfam PF07980 SusD family 273 566 3.6E-44 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS21445 e36981cee2bd1dd02d56266a05c4b00c 566 SUPERFAMILY SSF48452 21 492 7.05E-101 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21445 e36981cee2bd1dd02d56266a05c4b00c 566 SUPERFAMILY SSF48452 535 566 7.05E-101 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21445 e36981cee2bd1dd02d56266a05c4b00c 566 Pfam PF14322 Starch-binding associating with outer membrane 40 212 6.2E-11 T 21-04-2016 SPH21_RS11175 4eb95a10a39a4dc515eaf9403e638786 86 Gene3D G3DSA:3.30.2080.10 27 78 2.2E-13 T 21-04-2016 SPH21_RS11175 4eb95a10a39a4dc515eaf9403e638786 86 Pfam PF07971 Glycosyl hydrolase family 92 27 76 7.1E-8 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS25205 b35c88a1a5a9ece1b6efd7a8b495a4c2 505 Gene3D G3DSA:1.25.40.10 208 441 8.4E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS25205 b35c88a1a5a9ece1b6efd7a8b495a4c2 505 Pfam PF07980 SusD family 356 505 4.8E-32 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS25205 b35c88a1a5a9ece1b6efd7a8b495a4c2 505 Pfam PF14322 Starch-binding associating with outer membrane 24 226 4.5E-27 T 21-04-2016 SPH21_RS25205 b35c88a1a5a9ece1b6efd7a8b495a4c2 505 SUPERFAMILY SSF48452 18 505 2.02E-110 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS07580 2a09a98f70d941b36255c27920f66f5e 284 PANTHER PTHR31350 90 278 2.8E-28 T 21-04-2016 SPH21_RS07580 2a09a98f70d941b36255c27920f66f5e 284 PANTHER PTHR31350:SF1 90 278 2.8E-28 T 21-04-2016 SPH21_RS07580 2a09a98f70d941b36255c27920f66f5e 284 Pfam PF13369 Transglutaminase-like superfamily 103 258 3.0E-40 T 21-04-2016 IPR032698 Protein SirB1, N-terminal SPH21_RS02875 0e292f95a4cc643f4b0d5a7e3f9b18fa 333 Pfam PF00294 pfkB family carbohydrate kinase 9 318 4.0E-28 T 21-04-2016 IPR011611 Carbohydrate kinase PfkB SPH21_RS02875 0e292f95a4cc643f4b0d5a7e3f9b18fa 333 PANTHER PTHR10584 1 318 3.2E-55 T 21-04-2016 SPH21_RS02875 0e292f95a4cc643f4b0d5a7e3f9b18fa 333 PANTHER PTHR10584:SF203 1 318 3.2E-55 T 21-04-2016 SPH21_RS02875 0e292f95a4cc643f4b0d5a7e3f9b18fa 333 SUPERFAMILY SSF53613 7 328 5.14E-59 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS02875 0e292f95a4cc643f4b0d5a7e3f9b18fa 333 Gene3D G3DSA:3.40.1190.20 6 327 2.5E-60 T 21-04-2016 IPR029056 Ribokinase-like SPH21_RS01470 1003d38fb928078cfd477d904cfaac18 556 Gene3D G3DSA:3.30.750.24 446 551 1.0E-18 T 21-04-2016 IPR002645 STAS domain SPH21_RS01470 1003d38fb928078cfd477d904cfaac18 556 PANTHER PTHR11814:SF112 20 553 3.0E-243 T 21-04-2016 SPH21_RS01470 1003d38fb928078cfd477d904cfaac18 556 Pfam PF01740 STAS domain 445 545 7.4E-16 T 21-04-2016 IPR002645 STAS domain SPH21_RS01470 1003d38fb928078cfd477d904cfaac18 556 PANTHER PTHR11814 20 553 3.0E-243 T 21-04-2016 IPR001902 SLC26A/SulP transporter GO:0008271|GO:0008272|GO:0016020|GO:0055085 Reactome: REACT_15518 SPH21_RS01470 1003d38fb928078cfd477d904cfaac18 556 SUPERFAMILY SSF52091 445 550 1.18E-19 T 21-04-2016 IPR002645 STAS domain SPH21_RS01470 1003d38fb928078cfd477d904cfaac18 556 Pfam PF00916 Sulfate permease family 23 385 1.7E-86 T 21-04-2016 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 SPH21_RS11050 4c189d554e0115040a28c24115efaf66 493 PANTHER PTHR11785 235 489 8.5E-133 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS11050 4c189d554e0115040a28c24115efaf66 493 PANTHER PTHR11785 12 209 8.5E-133 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS11050 4c189d554e0115040a28c24115efaf66 493 PANTHER PTHR11785:SF328 235 489 8.5E-133 T 21-04-2016 SPH21_RS11050 4c189d554e0115040a28c24115efaf66 493 PANTHER PTHR11785:SF328 12 209 8.5E-133 T 21-04-2016 SPH21_RS11050 4c189d554e0115040a28c24115efaf66 493 Pfam PF13520 Amino acid permease 30 465 8.2E-55 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS11050 4c189d554e0115040a28c24115efaf66 493 PIRSF PIRSF006060 7 492 2.1E-85 T 21-04-2016 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SPH21_RS05800 44ac3dc65d05edd870e02de66fa2de69 327 Pfam PF13349 Putative adhesin 42 324 1.1E-9 T 21-04-2016 IPR025164 Putative adhesin SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 PANTHER PTHR30572 422 814 3.0E-72 T 21-04-2016 SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 PANTHER PTHR30572 311 381 3.0E-72 T 21-04-2016 SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 PANTHER PTHR30572:SF4 422 814 3.0E-72 T 21-04-2016 SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 PANTHER PTHR30572:SF4 311 381 3.0E-72 T 21-04-2016 SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 Pfam PF02687 FtsX-like permease family 694 803 4.3E-12 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 Pfam PF02687 FtsX-like permease family 312 423 1.9E-14 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 Pfam PF12704 MacB-like periplasmic core domain 456 654 3.4E-11 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS05890 680c3ffe3255da510694aab9d7e21f7b 814 Pfam PF12704 MacB-like periplasmic core domain 22 249 5.6E-13 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS17250 594c06153ab6064f86c320c1b854ac20 1205 TIGRFAM TIGR01760 tape_meas_TP901: phage tail tape measure protein, TP901 family, core region 105 404 6.4E-17 T 21-04-2016 IPR010090 Phage tail tape measure protein SPH21_RS17250 594c06153ab6064f86c320c1b854ac20 1205 Pfam PF10145 Phage-related minor tail protein 142 350 1.4E-10 T 21-04-2016 IPR010090 Phage tail tape measure protein SPH21_RS18580 38344b2793ba1af2799da81e10461e18 171 PANTHER PTHR13939 10 168 2.1E-25 T 21-04-2016 SPH21_RS18580 38344b2793ba1af2799da81e10461e18 171 SUPERFAMILY SSF142433 9 159 3.79E-32 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS18580 38344b2793ba1af2799da81e10461e18 171 Gene3D G3DSA:3.90.950.20 7 161 1.1E-37 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS18580 38344b2793ba1af2799da81e10461e18 171 TIGRFAM TIGR00199 PncC_domain: amidohydrolase, PncC family 14 156 2.4E-27 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS18580 38344b2793ba1af2799da81e10461e18 171 PANTHER PTHR13939:SF0 10 168 2.1E-25 T 21-04-2016 SPH21_RS18580 38344b2793ba1af2799da81e10461e18 171 Pfam PF02464 Competence-damaged protein 10 151 1.2E-32 T 21-04-2016 IPR008136 CinA, C-terminal SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 Pfam PF01494 FAD binding domain 300 335 5.3E-8 T 21-04-2016 IPR002938 FAD-binding domain GO:0071949 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 Pfam PF01494 FAD binding domain 7 172 3.8E-6 T 21-04-2016 IPR002938 FAD-binding domain GO:0071949 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 298 313 2.9E-22 T 21-04-2016 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 7 29 2.9E-22 T 21-04-2016 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 156 171 2.9E-22 T 21-04-2016 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 313 329 2.9E-22 T 21-04-2016 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 PANTHER PTHR13789 1 380 1.0E-108 T 21-04-2016 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 PANTHER PTHR13789:SF174 1 380 1.0E-108 T 21-04-2016 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 Gene3D G3DSA:3.50.50.60 284 368 5.1E-39 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 Gene3D G3DSA:3.50.50.60 5 182 5.1E-39 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 SUPERFAMILY SSF51905 283 378 5.94E-46 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS04080 31498405a92f3f49fcc5dbaea39163e4 387 SUPERFAMILY SSF51905 6 177 5.94E-46 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.60.40.1120 130 218 2.3E-15 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.40.170.20 1077 1160 6.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.40.170.20 343 359 6.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.40.170.20 993 1045 6.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.40.170.20 938 939 6.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.40.170.20 432 520 6.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.40.170.20 555 901 6.4E-58 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 PANTHER PTHR11532 592 1158 1.9E-222 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 PANTHER PTHR11532 115 477 1.9E-222 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 SUPERFAMILY SSF49464 128 209 4.97E-18 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 PANTHER PTHR11532:SF57 592 1158 1.9E-222 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 PANTHER PTHR11532:SF57 115 477 1.9E-222 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Gene3D G3DSA:2.170.130.10 219 342 2.4E-21 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Pfam PF13715 CarboxypepD_reg-like domain 130 211 2.0E-17 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 315 345 4.6E-16 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 SUPERFAMILY SSF56935 984 1028 8.55E-95 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 SUPERFAMILY SSF56935 423 511 8.55E-95 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 SUPERFAMILY SSF56935 560 901 8.55E-95 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 SUPERFAMILY SSF56935 1067 1160 8.55E-95 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 SUPERFAMILY SSF56935 208 363 8.55E-95 T 21-04-2016 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 129 1160 7.8E-236 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS24720 e7a20fd84be6be0a1e75cf97ac96d047 1160 Pfam PF07715 TonB-dependent Receptor Plug Domain 219 339 9.1E-20 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS04950 53be5f0736f129005e77744a8bf5f3df 540 Pfam PF07980 SusD family 269 540 1.6E-27 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS04950 53be5f0736f129005e77744a8bf5f3df 540 Gene3D G3DSA:1.25.40.10 202 318 1.2E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04950 53be5f0736f129005e77744a8bf5f3df 540 Gene3D G3DSA:1.25.40.10 365 478 1.2E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04950 53be5f0736f129005e77744a8bf5f3df 540 SUPERFAMILY SSF48452 462 540 2.53E-91 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04950 53be5f0736f129005e77744a8bf5f3df 540 SUPERFAMILY SSF48452 26 430 2.53E-91 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04950 53be5f0736f129005e77744a8bf5f3df 540 Pfam PF14322 Starch-binding associating with outer membrane 95 222 4.2E-9 T 21-04-2016 SPH21_RS10030 97707394631274b296cfc3659e455bcf 346 SUPERFAMILY SSF51445 48 341 2.64E-28 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS10030 97707394631274b296cfc3659e455bcf 346 Gene3D G3DSA:3.20.20.80 111 328 1.5E-13 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS10030 97707394631274b296cfc3659e455bcf 346 Pfam PF11790 Glycosyl hydrolase catalytic core 220 308 2.7E-6 T 21-04-2016 IPR024655 Uncharacterised protein family, glycosyl hydrolase catalytic domain SPH21_RS24145 2ea145eab11061b0c0d764050cdd4b7d 260 Gene3D G3DSA:3.40.50.1820 37 255 4.7E-30 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24145 2ea145eab11061b0c0d764050cdd4b7d 260 Pfam PF12697 Alpha/beta hydrolase family 39 251 9.2E-16 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS24145 2ea145eab11061b0c0d764050cdd4b7d 260 SUPERFAMILY SSF53474 158 255 7.11E-28 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24145 2ea145eab11061b0c0d764050cdd4b7d 260 SUPERFAMILY SSF53474 29 128 7.11E-28 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS24145 2ea145eab11061b0c0d764050cdd4b7d 260 PANTHER PTHR10992:SF832 37 259 5.9E-31 T 21-04-2016 SPH21_RS24145 2ea145eab11061b0c0d764050cdd4b7d 260 PANTHER PTHR10992 37 259 5.9E-31 T 21-04-2016 SPH21_RS19115 b6b45777814bd68a98c5fe8a2d8f977a 282 Gene3D G3DSA:2.40.50.140 3 55 1.1E-7 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS19115 b6b45777814bd68a98c5fe8a2d8f977a 282 Pfam PF00313 'Cold-shock' DNA-binding domain 4 46 2.7E-6 T 21-04-2016 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SPH21_RS19115 b6b45777814bd68a98c5fe8a2d8f977a 282 SUPERFAMILY SSF50249 1 46 3.43E-7 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS10435 8727d46c206b45e9d15890bfaeb6c7c2 439 PANTHER PTHR20992 22 379 2.7E-57 T 21-04-2016 SPH21_RS10435 8727d46c206b45e9d15890bfaeb6c7c2 439 Pfam PF04087 Domain of unknown function (DUF389) 63 198 1.1E-40 T 21-04-2016 IPR005240 Protein of unknown function DUF389 SPH21_RS10435 8727d46c206b45e9d15890bfaeb6c7c2 439 PANTHER PTHR20992:SF9 22 379 2.7E-57 T 21-04-2016 SPH21_RS01030 9c26f8c499961fcdcf48e27c66b30d7a 393 SUPERFAMILY SSF48695 32 92 3.24E-30 T 21-04-2016 IPR011031 Multihaem cytochrome SPH21_RS01030 9c26f8c499961fcdcf48e27c66b30d7a 393 SUPERFAMILY SSF48695 169 364 3.24E-30 T 21-04-2016 IPR011031 Multihaem cytochrome SPH21_RS01030 9c26f8c499961fcdcf48e27c66b30d7a 393 Gene3D G3DSA:1.10.710.10 40 83 4.7E-25 T 21-04-2016 IPR023155 Cytochrome c-552/4 KEGG: 00910+1.7.2.2|MetaCyc: PWY-5674|UniPathway: UPA00653 SPH21_RS01030 9c26f8c499961fcdcf48e27c66b30d7a 393 Gene3D G3DSA:1.10.710.10 163 259 4.7E-25 T 21-04-2016 IPR023155 Cytochrome c-552/4 KEGG: 00910+1.7.2.2|MetaCyc: PWY-5674|UniPathway: UPA00653 SPH21_RS01030 9c26f8c499961fcdcf48e27c66b30d7a 393 Gene3D G3DSA:1.10.710.10 296 364 4.7E-25 T 21-04-2016 IPR023155 Cytochrome c-552/4 KEGG: 00910+1.7.2.2|MetaCyc: PWY-5674|UniPathway: UPA00653 SPH21_RS10220 0154fdbcbe5d34f173b30f8c2e574fe2 313 PANTHER PTHR22916 1 310 1.0E-30 T 21-04-2016 SPH21_RS10220 0154fdbcbe5d34f173b30f8c2e574fe2 313 Gene3D G3DSA:3.90.550.10 4 236 1.8E-33 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS10220 0154fdbcbe5d34f173b30f8c2e574fe2 313 Pfam PF00535 Glycosyl transferase family 2 5 132 1.5E-22 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS10220 0154fdbcbe5d34f173b30f8c2e574fe2 313 SUPERFAMILY SSF53448 4 225 1.03E-36 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS00535 35a5f6ae5a7583e413314874f4d942dc 581 Pfam PF07980 SusD family 306 581 1.4E-44 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS00535 35a5f6ae5a7583e413314874f4d942dc 581 SUPERFAMILY SSF48452 21 512 1.9E-94 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00535 35a5f6ae5a7583e413314874f4d942dc 581 SUPERFAMILY SSF48452 549 581 1.9E-94 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00535 35a5f6ae5a7583e413314874f4d942dc 581 Pfam PF14322 Starch-binding associating with outer membrane 62 216 4.9E-13 T 21-04-2016 SPH21_RS00535 35a5f6ae5a7583e413314874f4d942dc 581 Gene3D G3DSA:1.25.40.10 387 486 2.9E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS00535 35a5f6ae5a7583e413314874f4d942dc 581 Gene3D G3DSA:1.25.40.10 196 319 2.9E-31 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS04035 b579bba1239efeebdac33387027e0210 153 SUPERFAMILY SSF52833 42 150 1.05E-26 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS04035 b579bba1239efeebdac33387027e0210 153 Gene3D G3DSA:3.40.30.10 39 150 1.1E-25 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS04035 b579bba1239efeebdac33387027e0210 153 Pfam PF00085 Thioredoxin 54 145 2.2E-11 T 21-04-2016 IPR013766 Thioredoxin domain GO:0045454 SPH21_RS22825 0d80bc29dd979efad4a820e12efc1858 130 Pfam PF00436 Single-strand binding protein family 3 97 1.9E-19 T 21-04-2016 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 SPH21_RS22825 0d80bc29dd979efad4a820e12efc1858 130 PIRSF PIRSF002070 1 129 3.5E-24 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS22825 0d80bc29dd979efad4a820e12efc1858 130 SUPERFAMILY SSF50249 2 130 3.43E-28 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS22825 0d80bc29dd979efad4a820e12efc1858 130 TIGRFAM TIGR00621 ssb: single-stranded DNA-binding protein 3 122 7.1E-23 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS22825 0d80bc29dd979efad4a820e12efc1858 130 PANTHER PTHR10302 3 123 4.2E-17 T 21-04-2016 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 SPH21_RS22825 0d80bc29dd979efad4a820e12efc1858 130 PANTHER PTHR10302:SF0 3 123 4.2E-17 T 21-04-2016 SPH21_RS22825 0d80bc29dd979efad4a820e12efc1858 130 Gene3D G3DSA:2.40.50.140 2 130 3.1E-28 T 21-04-2016 IPR012340 Nucleic acid-binding, OB-fold SPH21_RS12870 26f640c8ca78b13afb89a697020768f7 264 SUPERFAMILY SSF54427 34 156 8.04E-12 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS12870 26f640c8ca78b13afb89a697020768f7 264 Pfam PF14534 Domain of unknown function (DUF4440) 37 156 1.1E-12 T 21-04-2016 IPR027843 Domain of unknown function DUF4440 SPH21_RS12870 26f640c8ca78b13afb89a697020768f7 264 Pfam PF11954 Domain of unknown function (DUF3471) 173 241 1.8E-7 T 21-04-2016 IPR021860 Peptidase S12, Pab87-related, C-terminal SPH21_RS12870 26f640c8ca78b13afb89a697020768f7 264 Gene3D G3DSA:3.10.450.50 36 156 4.7E-4 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 PANTHER PTHR30126:SF11 3 294 4.3E-80 T 21-04-2016 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 Gene3D G3DSA:3.40.190.10 89 232 6.1E-33 T 21-04-2016 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 Gene3D G3DSA:1.10.10.10 7 88 2.8E-24 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 SUPERFAMILY SSF46785 7 88 2.34E-18 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 9.2E-10 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 9.2E-10 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 9.2E-10 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 62 1.6E-17 T 21-04-2016 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 PANTHER PTHR30126 3 294 4.3E-80 T 21-04-2016 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 SUPERFAMILY SSF53850 89 295 2.76E-34 T 21-04-2016 SPH21_RS05220 2a15c5e60c595a2c7fa622e78a2a06ae 303 Pfam PF03466 LysR substrate binding domain 88 295 3.3E-38 T 21-04-2016 IPR005119 LysR, substrate-binding SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PANTHER PTHR22773 225 608 6.4E-202 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PANTHER PTHR22773 4 207 6.4E-202 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 46 65 1.7E-10 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 410 432 1.7E-10 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 489 510 1.7E-10 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 621 647 1.7E-10 T 21-04-2016 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 Pfam PF00361 Proton-conducting membrane transporter 137 440 2.9E-78 T 21-04-2016 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: REACT_6305 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 70 125 2.7E-18 T 21-04-2016 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 TIGRFAM TIGR01974 NDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L 15 621 4.1E-171 T 21-04-2016 IPR003945 NADH-plastoquinone oxidoreductase, chain 5 GO:0008137|GO:0042773|GO:0055114 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PANTHER PTHR22773:SF50 225 608 6.4E-202 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PANTHER PTHR22773:SF50 4 207 6.4E-202 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 331 343 1.5E-53 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 114 134 1.5E-53 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 265 291 1.5E-53 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 86 111 1.5E-53 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 243 264 1.5E-53 T 21-04-2016 SPH21_RS10875 4c2223a0d29f4d2a151a66fe9de6b557 685 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 449 468 1.5E-53 T 21-04-2016 SPH21_RS06745 14e818664897ba875362a55fc3ed9bba 215 PANTHER PTHR37298 5 215 2.9E-63 T 21-04-2016 SPH21_RS06745 14e818664897ba875362a55fc3ed9bba 215 SUPERFAMILY SSF109755 35 206 1.45E-5 T 21-04-2016 SPH21_RS06745 14e818664897ba875362a55fc3ed9bba 215 Pfam PF01865 Protein of unknown function DUF47 13 212 2.5E-26 T 21-04-2016 IPR018445 Putative phosphate transport regulator SPH21_RS10630 c453b90c27d0a9902576f808a7adc6a3 71 SUPERFAMILY SSF69047 1 59 2.62E-9 T 21-04-2016 IPR008462 CsbD-like SPH21_RS10630 c453b90c27d0a9902576f808a7adc6a3 71 Gene3D G3DSA:1.10.1470.10 1 60 1.5E-12 T 21-04-2016 IPR008462 CsbD-like SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 PANTHER PTHR13794:SF4 1 382 6.0E-143 T 21-04-2016 SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 SUPERFAMILY SSF51604 95 361 1.83E-78 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 Gene3D G3DSA:3.20.20.120 115 349 9.2E-87 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 82 107 - T 21-04-2016 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 Pfam PF13378 Enolase C-terminal domain-like 131 355 2.1E-64 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 ProSitePatterns PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 180 211 - T 21-04-2016 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 SMART SM00922 125 230 4.4E-21 T 21-04-2016 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 Gene3D G3DSA:3.30.390.10 1 114 6.5E-52 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 16 107 6.7E-27 T 21-04-2016 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 SUPERFAMILY SSF54826 1 111 3.7E-30 T 21-04-2016 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SPH21_RS22620 e7b5cfeb886c978e951d11a324cc2b2b 382 PANTHER PTHR13794 1 382 6.0E-143 T 21-04-2016 IPR001354 Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase GO:0003824|GO:0008152 SPH21_RS02070 fc64372d90b9cee2943f5497daf1e9a1 388 TIGRFAM TIGR01730 RND_mfp: efflux transporter, RND family, MFP subunit 47 380 5.8E-70 T 21-04-2016 IPR006143 RND efflux pump, membrane fusion protein GO:0016020|GO:0055085 SPH21_RS02070 fc64372d90b9cee2943f5497daf1e9a1 388 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 71 233 2.8E-10 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS02070 fc64372d90b9cee2943f5497daf1e9a1 388 SUPERFAMILY SSF111369 59 298 2.88E-49 T 21-04-2016 SPH21_RS02070 fc64372d90b9cee2943f5497daf1e9a1 388 PANTHER PTHR30158 47 386 1.7E-90 T 21-04-2016 SPH21_RS02070 fc64372d90b9cee2943f5497daf1e9a1 388 Gene3D G3DSA:2.40.50.100 178 210 9.7E-18 T 21-04-2016 SPH21_RS02070 fc64372d90b9cee2943f5497daf1e9a1 388 Gene3D G3DSA:2.40.50.100 70 103 9.7E-18 T 21-04-2016 SPH21_RS25785 ed76514dd03eaeeba60351a4d620de3e 76 Pfam PF09527 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter 18 70 5.1E-10 T 21-04-2016 IPR032820 Putative F0F1-ATPase subunit, Ca2+/Mg2+ transporter SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 Gene3D G3DSA:2.60.120.260 3063 3240 4.0E-57 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 Gene3D G3DSA:2.170.16.10 1922 2020 1.9E-14 T 21-04-2016 IPR028992 Hedgehog/Intein (Hint) domain SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 Gene3D G3DSA:2.170.16.10 2069 2143 5.4E-15 T 21-04-2016 IPR028992 Hedgehog/Intein (Hint) domain SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 SUPERFAMILY SSF51294 1924 2020 6.8E-17 T 21-04-2016 IPR028992 Hedgehog/Intein (Hint) domain SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 SMART SM01198 3057 3242 4.4E-53 T 21-04-2016 IPR007397 F-box associated (FBA) domain SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 SUPERFAMILY SSF49785 3063 3240 2.81E-40 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 Pfam PF05203 Hom_end-associated Hint 2071 2111 5.0E-9 T 21-04-2016 IPR007868 Hom-end-associated Hint GO:0030908 SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 Pfam PF05203 Hom_end-associated Hint 1925 1966 8.4E-9 T 21-04-2016 IPR007868 Hom-end-associated Hint GO:0030908 SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 SMART SM00306 1923 2026 0.052 T 21-04-2016 IPR003587 Hint domain N-terminal SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 SMART SM00306 2069 2172 0.0083 T 21-04-2016 IPR003587 Hint domain N-terminal SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 Pfam PF04300 F-box associated region 3071 3238 1.9E-49 T 21-04-2016 IPR007397 F-box associated (FBA) domain SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 PANTHER PTHR12125 3056 3279 5.7E-50 T 21-04-2016 SPH21_RS21760 829177163dada7c574ad0c445d8d27be 3515 SUPERFAMILY SSF51294 2071 2170 2.49E-17 T 21-04-2016 IPR028992 Hedgehog/Intein (Hint) domain SPH21_RS02785 a769e71fccc68c21c86b447a7fdb22cb 491 Pfam PF03739 Predicted permease YjgP/YjgQ family 8 453 1.6E-92 T 21-04-2016 IPR005495 Permease LptG/LptF-related GO:0016021 SPH21_RS02785 a769e71fccc68c21c86b447a7fdb22cb 491 PANTHER PTHR33529 1 259 4.9E-62 T 21-04-2016 SPH21_RS02785 a769e71fccc68c21c86b447a7fdb22cb 491 PANTHER PTHR33529 349 489 4.9E-62 T 21-04-2016 SPH21_RS02785 a769e71fccc68c21c86b447a7fdb22cb 491 PANTHER PTHR33529:SF2 1 259 4.9E-62 T 21-04-2016 SPH21_RS02785 a769e71fccc68c21c86b447a7fdb22cb 491 PANTHER PTHR33529:SF2 349 489 4.9E-62 T 21-04-2016 SPH21_RS07185 44e00735ec373ef2d6310a426f65d022 821 Pfam PF13715 CarboxypepD_reg-like domain 25 108 1.5E-15 T 21-04-2016 SPH21_RS07185 44e00735ec373ef2d6310a426f65d022 821 Gene3D G3DSA:2.50.20.10 242 332 3.5E-4 T 21-04-2016 SPH21_RS07185 44e00735ec373ef2d6310a426f65d022 821 PANTHER PTHR11532 6 108 4.4E-16 T 21-04-2016 SPH21_RS07185 44e00735ec373ef2d6310a426f65d022 821 Gene3D G3DSA:2.60.40.1120 24 87 3.3E-13 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS07185 44e00735ec373ef2d6310a426f65d022 821 PANTHER PTHR11532:SF57 6 108 4.4E-16 T 21-04-2016 SPH21_RS07185 44e00735ec373ef2d6310a426f65d022 821 SUPERFAMILY SSF49464 23 106 5.89E-12 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS21965 e9425fa357747c5161c14e8e4e05c189 166 SUPERFAMILY SSF109854 5 145 1.26E-27 T 21-04-2016 SPH21_RS21965 e9425fa357747c5161c14e8e4e05c189 166 Gene3D G3DSA:1.20.120.450 2 160 2.7E-28 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS21965 e9425fa357747c5161c14e8e4e05c189 166 Pfam PF05163 DinB family 3 149 1.4E-20 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 215 245 9.1E-15 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 PANTHER PTHR11532 523 1030 4.7E-252 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 PANTHER PTHR11532 206 451 4.7E-252 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 PANTHER PTHR11532 1 190 4.7E-252 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 Gene3D G3DSA:2.170.130.10 109 243 5.5E-19 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 SUPERFAMILY SSF49464 26 105 3.53E-14 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 Gene3D G3DSA:2.60.40.1120 27 108 2.7E-12 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 SUPERFAMILY SSF56935 850 894 3.66E-80 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 SUPERFAMILY SSF56935 940 1032 3.66E-80 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 SUPERFAMILY SSF56935 104 262 3.66E-80 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 SUPERFAMILY SSF56935 454 791 3.66E-80 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 SUPERFAMILY SSF56935 327 415 3.66E-80 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 Pfam PF07715 TonB-dependent Receptor Plug Domain 117 239 2.7E-18 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 Gene3D G3DSA:2.40.170.20 335 791 1.4E-41 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 PANTHER PTHR11532:SF51 523 1030 4.7E-252 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 PANTHER PTHR11532:SF51 206 451 4.7E-252 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 PANTHER PTHR11532:SF51 1 190 4.7E-252 T 21-04-2016 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 26 1032 9.1E-197 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS09735 567641200837a64640f506bb28ec9660 1032 Pfam PF13715 CarboxypepD_reg-like domain 28 107 8.9E-16 T 21-04-2016 SPH21_RS19355 9a541056271ce982bb389badab41e2f4 449 SUPERFAMILY SSF103473 12 443 1.27E-38 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS19355 9a541056271ce982bb389badab41e2f4 449 Gene3D G3DSA:1.20.1250.20 257 441 1.5E-10 T 21-04-2016 SPH21_RS19355 9a541056271ce982bb389badab41e2f4 449 Gene3D G3DSA:1.20.1250.20 14 221 1.8E-20 T 21-04-2016 SPH21_RS19355 9a541056271ce982bb389badab41e2f4 449 PANTHER PTHR19432:SF35 1 443 2.7E-91 T 21-04-2016 SPH21_RS19355 9a541056271ce982bb389badab41e2f4 449 PANTHER PTHR19432 1 443 2.7E-91 T 21-04-2016 SPH21_RS19355 9a541056271ce982bb389badab41e2f4 449 Pfam PF07690 Major Facilitator Superfamily 19 404 4.0E-25 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS05545 a2c1d35378698edb5cc28c077100b8ab 280 SUPERFAMILY SSF48452 101 273 9.21E-18 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS05545 a2c1d35378698edb5cc28c077100b8ab 280 PANTHER PTHR23083 146 271 1.9E-14 T 21-04-2016 SPH21_RS05545 a2c1d35378698edb5cc28c077100b8ab 280 Pfam PF13432 Tetratricopeptide repeat 211 260 2.2E-5 T 21-04-2016 SPH21_RS05545 a2c1d35378698edb5cc28c077100b8ab 280 Gene3D G3DSA:1.25.40.10 114 265 2.5E-21 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12985 36dbb3334935a0123a3d53b9f0a0da30 313 Gene3D G3DSA:3.40.50.2300 146 306 1.2E-48 T 21-04-2016 SPH21_RS12985 36dbb3334935a0123a3d53b9f0a0da30 313 Pfam PF13407 Periplasmic binding protein domain 29 283 1.3E-53 T 21-04-2016 IPR025997 Periplasmic binding protein SPH21_RS12985 36dbb3334935a0123a3d53b9f0a0da30 313 SUPERFAMILY SSF53822 26 306 3.53E-74 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS12985 36dbb3334935a0123a3d53b9f0a0da30 313 PANTHER PTHR32196:SF9 24 302 7.7E-83 T 21-04-2016 SPH21_RS12985 36dbb3334935a0123a3d53b9f0a0da30 313 PANTHER PTHR32196 24 302 7.7E-83 T 21-04-2016 SPH21_RS12985 36dbb3334935a0123a3d53b9f0a0da30 313 Gene3D G3DSA:3.40.50.2300 26 145 7.5E-29 T 21-04-2016 SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 Gene3D G3DSA:2.160.20.10 61 326 4.2E-28 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 SUPERFAMILY SSF51126 49 320 6.44E-31 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 Pfam PF13229 Right handed beta helix region 119 240 1.6E-8 T 21-04-2016 SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 SMART SM00710 254 276 560.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 SMART SM00710 202 224 4.9 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 SMART SM00710 226 253 1800.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 SMART SM00710 179 201 8100.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 SMART SM00710 156 178 5.4 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS04530 af4c14bec86f2e521514f5bb695a1ee4 330 SMART SM00710 282 304 660.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS04005 06f864ade797e9baef99ea6f4a210af9 275 PANTHER PTHR30177:SF2 1 268 9.3E-122 T 21-04-2016 SPH21_RS04005 06f864ade797e9baef99ea6f4a210af9 275 SUPERFAMILY SSF161098 80 264 6.28E-40 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS04005 06f864ade797e9baef99ea6f4a210af9 275 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 103 261 4.0E-24 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS04005 06f864ade797e9baef99ea6f4a210af9 275 PANTHER PTHR30177 1 268 9.3E-122 T 21-04-2016 SPH21_RS04005 06f864ade797e9baef99ea6f4a210af9 275 Gene3D G3DSA:1.10.3720.10 80 265 3.9E-41 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS10910 a41caa1389f636224bf5b657b1871ad5 224 Pfam PF13649 Methyltransferase domain 47 140 2.5E-16 T 21-04-2016 SPH21_RS10910 a41caa1389f636224bf5b657b1871ad5 224 SUPERFAMILY SSF53335 8 215 4.07E-33 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS10910 a41caa1389f636224bf5b657b1871ad5 224 Gene3D G3DSA:3.40.50.150 10 223 1.2E-34 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS10910 a41caa1389f636224bf5b657b1871ad5 224 PANTHER PTHR10108 2 217 8.0E-19 T 21-04-2016 SPH21_RS08670 2835054d58fedb3a05a06fc3b47623b4 513 Pfam PF05872 Bacterial protein of unknown function (DUF853) 35 481 2.6E-169 T 21-04-2016 IPR033186 Helicase HerA-like C-terminal SPH21_RS08670 2835054d58fedb3a05a06fc3b47623b4 513 Gene3D G3DSA:3.40.50.300 26 111 5.2E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08670 2835054d58fedb3a05a06fc3b47623b4 513 Gene3D G3DSA:3.40.50.300 229 395 5.2E-53 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08670 2835054d58fedb3a05a06fc3b47623b4 513 SUPERFAMILY SSF52540 26 397 1.59E-45 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08670 2835054d58fedb3a05a06fc3b47623b4 513 PANTHER PTHR30121:SF3 36 465 1.2E-123 T 21-04-2016 SPH21_RS08670 2835054d58fedb3a05a06fc3b47623b4 513 PANTHER PTHR30121 36 465 1.2E-123 T 21-04-2016 SPH21_RS19240 26b2a7392342d05cb2bef17b9f8e6a42 216 SUPERFAMILY SSF89392 29 215 5.89E-16 T 21-04-2016 IPR029046 Lipoprotein localisation LolA/LolB/LppX SPH21_RS19240 26b2a7392342d05cb2bef17b9f8e6a42 216 Gene3D G3DSA:2.50.20.10 29 214 1.2E-17 T 21-04-2016 SPH21_RS19240 26b2a7392342d05cb2bef17b9f8e6a42 216 Pfam PF03548 Outer membrane lipoprotein carrier protein LolA 38 203 7.6E-14 T 21-04-2016 IPR004564 Outer membrane lipoprotein carrier protein LolA-like SPH21_RS01140 605163f2d3ed2cd4f84d0f92655a3b43 163 Pfam PF13420 Acetyltransferase (GNAT) domain 3 151 4.4E-15 T 21-04-2016 SPH21_RS01140 605163f2d3ed2cd4f84d0f92655a3b43 163 PANTHER PTHR23091 1 156 5.6E-19 T 21-04-2016 SPH21_RS01140 605163f2d3ed2cd4f84d0f92655a3b43 163 Gene3D G3DSA:3.40.630.30 1 157 1.5E-37 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS01140 605163f2d3ed2cd4f84d0f92655a3b43 163 SUPERFAMILY SSF55729 1 156 8.23E-33 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS23650 2002983b9d58a32b18cfce021f5d2cb0 493 Gene3D G3DSA:1.25.40.10 224 439 6.9E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23650 2002983b9d58a32b18cfce021f5d2cb0 493 Pfam PF14322 Starch-binding associating with outer membrane 82 244 1.7E-19 T 21-04-2016 SPH21_RS23650 2002983b9d58a32b18cfce021f5d2cb0 493 SUPERFAMILY SSF48452 18 493 4.05E-101 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS23650 2002983b9d58a32b18cfce021f5d2cb0 493 Pfam PF07980 SusD family 349 493 6.1E-26 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS08555 0eaf4faad25ac055f03fec892d80104f 188 SUPERFAMILY SSF55282 6 182 1.93E-72 T 21-04-2016 IPR022803 Ribosomal protein L5 domain SPH21_RS08555 0eaf4faad25ac055f03fec892d80104f 188 PANTHER PTHR11994 3 181 1.1E-79 T 21-04-2016 SPH21_RS08555 0eaf4faad25ac055f03fec892d80104f 188 PIRSF PIRSF002161 1 187 1.6E-63 T 21-04-2016 IPR002132 Ribosomal protein L5 GO:0003735|GO:0005840|GO:0006412 SPH21_RS08555 0eaf4faad25ac055f03fec892d80104f 188 Hamap MF_01333_B 50S ribosomal protein L5 [rplE]. 4 182 41.369 T 21-04-2016 IPR020930 Ribosomal protein L5, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SPH21_RS08555 0eaf4faad25ac055f03fec892d80104f 188 Gene3D G3DSA:3.30.1440.10 5 182 5.3E-73 T 21-04-2016 IPR022803 Ribosomal protein L5 domain SPH21_RS08555 0eaf4faad25ac055f03fec892d80104f 188 Pfam PF00673 ribosomal L5P family C-terminus 87 180 4.8E-39 T 21-04-2016 IPR031309 Ribosomal protein L5, C-terminal SPH21_RS08555 0eaf4faad25ac055f03fec892d80104f 188 Pfam PF00281 Ribosomal protein L5 27 83 5.3E-23 T 21-04-2016 IPR031310 Ribosomal protein L5, N-terminal SPH21_RS23205 f2cc7084e2341533b14cf0e2a4ec2f1c 398 PANTHER PTHR30273 194 398 2.3E-58 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS23205 f2cc7084e2341533b14cf0e2a4ec2f1c 398 PANTHER PTHR30273 1 123 2.3E-58 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS23205 f2cc7084e2341533b14cf0e2a4ec2f1c 398 PANTHER PTHR30273:SF2 194 398 2.3E-58 T 21-04-2016 SPH21_RS23205 f2cc7084e2341533b14cf0e2a4ec2f1c 398 PANTHER PTHR30273:SF2 1 123 2.3E-58 T 21-04-2016 SPH21_RS23205 f2cc7084e2341533b14cf0e2a4ec2f1c 398 Pfam PF16344 Domain of unknown function (DUF4974) 297 394 5.0E-20 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS23205 f2cc7084e2341533b14cf0e2a4ec2f1c 398 Pfam PF04773 FecR protein 193 286 4.3E-18 T 21-04-2016 IPR006860 FecR protein SPH21_RS24680 11809b449279782cd6915c166f72ab77 114 Gene3D G3DSA:1.10.10.10 5 112 2.2E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24680 11809b449279782cd6915c166f72ab77 114 SUPERFAMILY SSF46785 11 111 5.83E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24680 11809b449279782cd6915c166f72ab77 114 PANTHER PTHR33204 1 111 2.9E-24 T 21-04-2016 SPH21_RS24680 11809b449279782cd6915c166f72ab77 114 Pfam PF01638 HxlR-like helix-turn-helix 22 109 1.3E-19 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 1.0E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 131 139 1.0E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 170 1.0E-7 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 Gene3D G3DSA:3.40.50.720 2 212 4.8E-50 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PANTHER PTHR24322 151 183 6.1E-39 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PANTHER PTHR24322 10 135 6.1E-39 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 SUPERFAMILY SSF51735 1 232 7.66E-52 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 Pfam PF00106 short chain dehydrogenase 6 193 1.2E-43 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 2.8E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 170 2.8E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 2.8E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 2.8E-14 T 21-04-2016 IPR002347 Short-chain dehydrogenase/reductase SDR SPH21_RS21540 246570a3c6e27fae4f1211632572b4e8 262 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 138 166 - T 21-04-2016 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SPH21_RS03990 de90fd45cfc2a0321e2adc679c086785 383 PANTHER PTHR34219 1 369 1.1E-54 T 21-04-2016 SPH21_RS03990 de90fd45cfc2a0321e2adc679c086785 383 Pfam PF03929 PepSY-associated TM region 8 369 7.9E-66 T 21-04-2016 IPR005625 PepSY-associated TM protein SPH21_RS13905 6a75f068f37cd8c2da7dc312035e03cf 166 SUPERFAMILY SSF109854 2 162 2.44E-9 T 21-04-2016 SPH21_RS13905 6a75f068f37cd8c2da7dc312035e03cf 166 Gene3D G3DSA:1.20.120.450 2 164 3.9E-12 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS13905 6a75f068f37cd8c2da7dc312035e03cf 166 Pfam PF12867 DinB superfamily 15 159 5.5E-7 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS16330 2f4ca5f52e6de659c69c3f0105be5f8f 291 Pfam PF02653 Branched-chain amino acid transport system / permease component 8 276 3.0E-28 T 21-04-2016 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SPH21_RS16330 2f4ca5f52e6de659c69c3f0105be5f8f 291 PANTHER PTHR32196 5 281 1.1E-72 T 21-04-2016 SPH21_RS16330 2f4ca5f52e6de659c69c3f0105be5f8f 291 PANTHER PTHR32196:SF27 5 281 1.1E-72 T 21-04-2016 SPH21_RS05370 9a80fdddf70292eee8ce858f80309a55 375 Pfam PF06580 Histidine kinase 171 248 6.4E-20 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS05370 9a80fdddf70292eee8ce858f80309a55 375 PANTHER PTHR34220 43 365 1.6E-36 T 21-04-2016 SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 2.7E-9 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 2.7E-9 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 SUPERFAMILY SSF46689 2 67 1.4E-15 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 PANTHER PTHR30055 7 67 3.2E-16 T 21-04-2016 SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 ProSitePatterns PS01081 TetR-type HTH domain signature. 24 55 - T 21-04-2016 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 Gene3D G3DSA:1.10.357.10 1 171 1.6E-23 T 21-04-2016 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 56 1.1E-14 T 21-04-2016 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SPH21_RS18205 3d9e5d95a06f9a9dda46dcf7a251baec 180 PANTHER PTHR30055:SF75 7 67 3.2E-16 T 21-04-2016 SPH21_RS05990 2c7388a8286f7f18a565cc388ee141b3 583 Gene3D G3DSA:1.20.120.330 131 245 1.3E-8 T 21-04-2016 SPH21_RS05990 2c7388a8286f7f18a565cc388ee141b3 583 SUPERFAMILY SSF81593 131 247 7.46E-8 T 21-04-2016 SPH21_RS05990 2c7388a8286f7f18a565cc388ee141b3 583 Pfam PF05168 HEPN domain 131 245 9.9E-7 T 21-04-2016 IPR007842 HEPN domain SPH21_RS02670 ab77c0aef93542cbe978a868c41d331f 169 Gene3D G3DSA:3.40.630.30 2 163 7.2E-35 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS02670 ab77c0aef93542cbe978a868c41d331f 169 SUPERFAMILY SSF55729 1 143 1.89E-23 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS02670 ab77c0aef93542cbe978a868c41d331f 169 Pfam PF13673 Acetyltransferase (GNAT) domain 43 143 6.3E-12 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS02670 ab77c0aef93542cbe978a868c41d331f 169 PANTHER PTHR13947 37 158 1.3E-19 T 21-04-2016 SPH21_RS02880 2e01f49a90ab1023c150e9ddfd123692 216 PANTHER PTHR30246 1 212 7.1E-55 T 21-04-2016 SPH21_RS02880 2e01f49a90ab1023c150e9ddfd123692 216 Pfam PF01081 KDPG and KHG aldolase 10 194 3.4E-31 T 21-04-2016 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SPH21_RS02880 2e01f49a90ab1023c150e9ddfd123692 216 Gene3D G3DSA:3.20.20.70 6 213 7.6E-61 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS02880 2e01f49a90ab1023c150e9ddfd123692 216 SUPERFAMILY SSF51569 8 212 2.01E-51 T 21-04-2016 SPH21_RS02880 2e01f49a90ab1023c150e9ddfd123692 216 PANTHER PTHR30246:SF4 1 212 7.1E-55 T 21-04-2016 SPH21_RS22550 98173e75687be6cc7282a5b8ff1e7043 324 Gene3D G3DSA:1.10.10.60 278 323 1.0E-10 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22550 98173e75687be6cc7282a5b8ff1e7043 324 Pfam PF12833 Helix-turn-helix domain 246 322 3.1E-12 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22550 98173e75687be6cc7282a5b8ff1e7043 324 Pfam PF12625 Arabinose-binding domain of AraC transcription regulator, N-term 37 161 1.5E-7 T 21-04-2016 IPR032687 HTH-type transcriptional regulator AraC-type, N-terminal SPH21_RS22550 98173e75687be6cc7282a5b8ff1e7043 324 PANTHER PTHR11019 240 323 7.2E-23 T 21-04-2016 SPH21_RS22550 98173e75687be6cc7282a5b8ff1e7043 324 SMART SM00342 239 321 2.1E-15 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS22550 98173e75687be6cc7282a5b8ff1e7043 324 SUPERFAMILY SSF46689 277 323 1.25E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22550 98173e75687be6cc7282a5b8ff1e7043 324 PANTHER PTHR11019:SF52 240 323 7.2E-23 T 21-04-2016 SPH21_RS07645 89451b137d15d7e07d32ec9dac38b553 192 Pfam PF01812 5-formyltetrahydrofolate cyclo-ligase family 4 184 7.7E-24 T 21-04-2016 IPR002698 5-formyltetrahydrofolate cyclo-ligase SPH21_RS07645 89451b137d15d7e07d32ec9dac38b553 192 PIRSF PIRSF006806 1 187 1.4E-29 T 21-04-2016 IPR002698 5-formyltetrahydrofolate cyclo-ligase SPH21_RS07645 89451b137d15d7e07d32ec9dac38b553 192 TIGRFAM TIGR02727 MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase 4 184 1.0E-30 T 21-04-2016 IPR002698 5-formyltetrahydrofolate cyclo-ligase SPH21_RS07645 89451b137d15d7e07d32ec9dac38b553 192 SUPERFAMILY SSF100950 3 191 6.84E-33 T 21-04-2016 SPH21_RS07645 89451b137d15d7e07d32ec9dac38b553 192 Gene3D G3DSA:3.40.50.10420 3 190 3.1E-33 T 21-04-2016 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SPH21_RS07645 89451b137d15d7e07d32ec9dac38b553 192 PANTHER PTHR23407 1 191 5.3E-26 T 21-04-2016 SPH21_RS07645 89451b137d15d7e07d32ec9dac38b553 192 PANTHER PTHR23407:SF1 1 191 5.3E-26 T 21-04-2016 IPR002698 5-formyltetrahydrofolate cyclo-ligase SPH21_RS20350 2d1885fc4063bba710bf411430d91606 176 SUPERFAMILY SSF109854 4 164 9.34E-22 T 21-04-2016 SPH21_RS20350 2d1885fc4063bba710bf411430d91606 176 Gene3D G3DSA:1.20.120.450 9 163 4.2E-13 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS20350 2d1885fc4063bba710bf411430d91606 176 Pfam PF05163 DinB family 27 161 8.1E-7 T 21-04-2016 IPR007837 DNA damage-inducible protein DinB SPH21_RS09875 3d3d2990748090f042b50ad74f1f289d 375 PANTHER PTHR30590:SF2 1 367 7.2E-53 T 21-04-2016 SPH21_RS09875 3d3d2990748090f042b50ad74f1f289d 375 Pfam PF04235 Protein of unknown function (DUF418) 239 351 1.5E-24 T 21-04-2016 IPR007349 Domain of unknown function DUF418 SPH21_RS09875 3d3d2990748090f042b50ad74f1f289d 375 PANTHER PTHR30590 1 367 7.2E-53 T 21-04-2016 SPH21_RS09875 3d3d2990748090f042b50ad74f1f289d 375 Pfam PF07786 Protein of unknown function (DUF1624) 12 205 5.3E-8 T 21-04-2016 IPR012429 Protein of unknown function DUF1624 KEGG: 00531+2.3.1.78 SPH21_RS26270 e562614f719066487c53764d95f4ff45 438 Pfam PF00754 F5/8 type C domain 314 428 7.2E-10 T 21-04-2016 IPR000421 Coagulation factor 5/8 C-terminal domain SPH21_RS26270 e562614f719066487c53764d95f4ff45 438 Gene3D G3DSA:2.60.120.260 309 435 3.2E-16 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS26270 e562614f719066487c53764d95f4ff45 438 SUPERFAMILY SSF49785 312 424 2.13E-15 T 21-04-2016 IPR008979 Galactose-binding domain-like SPH21_RS04695 8bb0d5e1418d09419e553eb20bd3037b 145 Gene3D G3DSA:3.30.70.900 20 112 4.2E-8 T 21-04-2016 SPH21_RS04695 8bb0d5e1418d09419e553eb20bd3037b 145 SUPERFAMILY SSF54909 29 133 5.9E-15 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS04695 8bb0d5e1418d09419e553eb20bd3037b 145 Pfam PF07978 NIPSNAP 31 108 6.5E-12 T 21-04-2016 IPR012577 NIPSNAP SPH21_RS16395 cd9e0538536a8c8167626cc067fdc4cb 376 Pfam PF01636 Phosphotransferase enzyme family 28 270 8.8E-16 T 21-04-2016 IPR002575 Aminoglycoside phosphotransferase SPH21_RS16395 cd9e0538536a8c8167626cc067fdc4cb 376 SUPERFAMILY SSF56112 9 353 1.22E-29 T 21-04-2016 IPR011009 Protein kinase-like domain SPH21_RS16395 cd9e0538536a8c8167626cc067fdc4cb 376 Gene3D G3DSA:3.90.1200.10 134 356 6.1E-15 T 21-04-2016 SPH21_RS22630 ae05b7e441e3f678d45c776f8b736b98 323 Pfam PF05035 2-keto-3-deoxy-galactonokinase 8 309 9.5E-68 T 21-04-2016 IPR007729 2-keto-3-deoxy-galactonokinase GO:0008671|GO:0034194 KEGG: 00052+2.7.1.58|MetaCyc: PWY-7130|UniPathway: UPA00081 SPH21_RS23720 9b105cc3caab17e0042746dbda336763 270 Pfam PF14054 Domain of unknown function (DUF4249) 9 265 1.0E-34 T 21-04-2016 IPR025345 Protein of unknown function DUF4249 SPH21_RS17785 1c5ba5c4102a037d3e99164ed6fce155 835 Pfam PF12991 Domain of unknown function, B. Theta Gene description (DUF3875) 3 55 9.5E-27 T 21-04-2016 IPR024451 Domain of unknown function DUF3875 SPH21_RS17785 1c5ba5c4102a037d3e99164ed6fce155 835 PANTHER PTHR38467 2 835 1.4E-276 T 21-04-2016 SPH21_RS17785 1c5ba5c4102a037d3e99164ed6fce155 835 TIGRFAM TIGR03783 Bac_Flav_CT_G: Bacteroides conjugation system ATPase, TraG family 1 827 0.0 T 21-04-2016 IPR022509 Conjugation system ATPase, TraG SPH21_RS17785 1c5ba5c4102a037d3e99164ed6fce155 835 SUPERFAMILY SSF52540 408 753 8.36E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17785 1c5ba5c4102a037d3e99164ed6fce155 835 Gene3D G3DSA:3.40.50.300 593 753 3.1E-12 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17785 1c5ba5c4102a037d3e99164ed6fce155 835 Gene3D G3DSA:3.40.50.300 421 518 3.1E-12 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS21470 06f1c55678d1526fe7010d8dac336d6f 135 Pfam PF01042 Endoribonuclease L-PSP 19 126 2.2E-27 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS21470 06f1c55678d1526fe7010d8dac336d6f 135 SUPERFAMILY SSF55298 3 128 5.97E-35 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS21470 06f1c55678d1526fe7010d8dac336d6f 135 Gene3D G3DSA:3.30.1330.40 3 129 4.9E-41 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS21470 06f1c55678d1526fe7010d8dac336d6f 135 PANTHER PTHR11803 20 133 2.6E-35 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS13720 d52c16734c0bf6c1eac66e2dd7fbf8e5 219 Pfam PF09335 SNARE associated Golgi protein 42 175 2.9E-20 T 21-04-2016 IPR032816 SNARE associated Golgi protein SPH21_RS13720 d52c16734c0bf6c1eac66e2dd7fbf8e5 219 PANTHER PTHR30353:SF0 1 212 1.8E-58 T 21-04-2016 SPH21_RS13720 d52c16734c0bf6c1eac66e2dd7fbf8e5 219 PANTHER PTHR30353 1 212 1.8E-58 T 21-04-2016 IPR032818 DedA family SPH21_RS16320 c0d30b3e981b5489436b6d9326b1a471 382 SUPERFAMILY SSF53383 2 381 2.96E-95 T 21-04-2016 IPR015424 Pyridoxal phosphate-dependent transferase SPH21_RS16320 c0d30b3e981b5489436b6d9326b1a471 382 Gene3D G3DSA:3.40.640.10 41 268 1.3E-72 T 21-04-2016 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SPH21_RS16320 c0d30b3e981b5489436b6d9326b1a471 382 PANTHER PTHR11751:SF301 7 381 5.3E-125 T 21-04-2016 SPH21_RS16320 c0d30b3e981b5489436b6d9326b1a471 382 Gene3D G3DSA:3.90.1150.10 269 380 7.1E-20 T 21-04-2016 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SPH21_RS16320 c0d30b3e981b5489436b6d9326b1a471 382 Pfam PF00155 Aminotransferase class I and II 29 378 3.8E-55 T 21-04-2016 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SPH21_RS16320 c0d30b3e981b5489436b6d9326b1a471 382 PANTHER PTHR11751 7 381 5.3E-125 T 21-04-2016 SPH21_RS12390 6f2bc64a14133968c82354ede2e259b3 505 SUPERFAMILY SSF48452 20 504 8.09E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS12390 6f2bc64a14133968c82354ede2e259b3 505 Pfam PF12771 Starch-binding associating with outer membrane 1 504 1.7E-65 T 21-04-2016 SPH21_RS12390 6f2bc64a14133968c82354ede2e259b3 505 PANTHER PTHR35148 1 502 2.1E-44 T 21-04-2016 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 Gene3D G3DSA:1.20.1610.10 445 604 3.2E-67 T 21-04-2016 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 PANTHER PTHR12143 3 761 0.0 T 21-04-2016 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 Gene3D G3DSA:1.20.1050.60 352 438 7.1E-33 T 21-04-2016 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 4 745 3.0E-250 T 21-04-2016 IPR005887 Alpha-1,2-mannosidase, putative KEGG: 00130+3.2.1.-|KEGG: 00531+3.2.1.- SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 Gene3D G3DSA:2.70.98.10 27 324 5.9E-102 T 21-04-2016 IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup GO:0003824|GO:0005975|GO:0030246 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 SUPERFAMILY SSF48208 265 734 2.72E-38 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 Gene3D G3DSA:3.30.2080.10 605 750 1.2E-65 T 21-04-2016 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 PANTHER PTHR12143:SF22 3 761 0.0 T 21-04-2016 SPH21_RS10935 20f6ff28408d3172bf527e323d492f89 763 Pfam PF07971 Glycosyl hydrolase family 92 242 740 3.0E-167 T 21-04-2016 IPR012939 Glycosyl hydrolase family 92 SPH21_RS14200 8046a72ac66df8fdac6c1b4cf5e71b84 490 Pfam PF07980 SusD family 325 490 4.7E-32 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS14200 8046a72ac66df8fdac6c1b4cf5e71b84 490 Gene3D G3DSA:1.25.40.10 200 422 9.0E-33 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14200 8046a72ac66df8fdac6c1b4cf5e71b84 490 SUPERFAMILY SSF48452 16 490 7.6E-108 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS14200 8046a72ac66df8fdac6c1b4cf5e71b84 490 Pfam PF14322 Starch-binding associating with outer membrane 90 215 5.8E-22 T 21-04-2016 SPH21_RS13840 56843d667202d36e4b3a717a2472da36 195 Gene3D G3DSA:2.60.120.590 12 192 4.2E-39 T 21-04-2016 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like SPH21_RS13840 56843d667202d36e4b3a717a2472da36 195 Pfam PF13532 2OG-Fe(II) oxygenase superfamily 12 190 4.5E-32 T 21-04-2016 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like SPH21_RS13840 56843d667202d36e4b3a717a2472da36 195 PANTHER PTHR31573 9 193 1.1E-63 T 21-04-2016 IPR032852 DNA oxidative demethylase ALKBH2 GO:0006281 SPH21_RS13840 56843d667202d36e4b3a717a2472da36 195 SUPERFAMILY SSF51197 7 192 6.45E-61 T 21-04-2016 SPH21_RS13840 56843d667202d36e4b3a717a2472da36 195 PANTHER PTHR31573:SF1 9 193 1.1E-63 T 21-04-2016 SPH21_RS18285 5aa518002ed5d1934f9da911e143b5b2 438 Pfam PF01594 Domain of unknown function DUF20 78 398 1.6E-55 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS18285 5aa518002ed5d1934f9da911e143b5b2 438 PANTHER PTHR21716 79 412 1.1E-56 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS07170 573df327f74c5a248f9745d363e8a551 286 Pfam PF01963 TraB family 30 284 4.7E-56 T 21-04-2016 IPR002816 Pheromone shutdown, TraB SPH21_RS07170 573df327f74c5a248f9745d363e8a551 286 PANTHER PTHR40590 3 282 6.9E-19 T 21-04-2016 SPH21_RS09810 da11b9c6d8c468f336842cba1473856a 251 Gene3D G3DSA:2.40.160.20 41 75 2.5E-4 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS09810 da11b9c6d8c468f336842cba1473856a 251 Gene3D G3DSA:2.40.160.20 116 221 2.5E-4 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS01285 28c642b9478ce09eb229d0e843689e1a 96 Gene3D G3DSA:1.10.260.40 14 85 4.6E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS01285 28c642b9478ce09eb229d0e843689e1a 96 SMART SM00530 22 78 0.003 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01285 28c642b9478ce09eb229d0e843689e1a 96 Pfam PF01381 Helix-turn-helix 24 78 2.6E-5 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS01285 28c642b9478ce09eb229d0e843689e1a 96 SUPERFAMILY SSF47413 16 84 2.67E-9 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 SUPERFAMILY SSF56317 228 514 1.12E-31 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 Gene3D G3DSA:3.60.110.10 224 506 1.5E-23 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 TIGRFAM TIGR00546 lnt: apolipoprotein N-acyltransferase 64 483 5.0E-75 T 21-04-2016 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 UniPathway: UPA00666 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 PANTHER PTHR23088 214 318 1.7E-48 T 21-04-2016 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 PANTHER PTHR23088 340 529 1.7E-48 T 21-04-2016 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 Pfam PF00795 Carbon-nitrogen hydrolase 337 504 2.7E-22 T 21-04-2016 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 Hamap MF_01148 Apolipoprotein N-acyltransferase [lnt]. 1 521 16.755 T 21-04-2016 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 UniPathway: UPA00666 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 PANTHER PTHR23088:SF29 214 318 1.7E-48 T 21-04-2016 SPH21_RS25710 bf0c7b26e8889cdaa21417adfb1304b5 546 PANTHER PTHR23088:SF29 340 529 1.7E-48 T 21-04-2016 SPH21_RS22490 796339dacf2f198eacfbd4f90bfc2b38 417 PANTHER PTHR23513 1 407 2.8E-65 T 21-04-2016 SPH21_RS22490 796339dacf2f198eacfbd4f90bfc2b38 417 Pfam PF07690 Major Facilitator Superfamily 12 362 1.3E-22 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS22490 796339dacf2f198eacfbd4f90bfc2b38 417 Gene3D G3DSA:1.20.1250.20 6 192 2.1E-18 T 21-04-2016 SPH21_RS22490 796339dacf2f198eacfbd4f90bfc2b38 417 Gene3D G3DSA:1.20.1250.20 217 401 9.1E-12 T 21-04-2016 SPH21_RS22490 796339dacf2f198eacfbd4f90bfc2b38 417 SUPERFAMILY SSF103473 6 407 1.57E-45 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS13440 93183f519f4e2f773b18cf535dc8fd18 251 Hamap MF_00691 UPF0271 protein YbgL [ybgL]. 2 246 43.152 T 21-04-2016 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SPH21_RS13440 93183f519f4e2f773b18cf535dc8fd18 251 PANTHER PTHR30292 1 251 6.9E-119 T 21-04-2016 SPH21_RS13440 93183f519f4e2f773b18cf535dc8fd18 251 SUPERFAMILY SSF88713 3 249 3.85E-96 T 21-04-2016 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SPH21_RS13440 93183f519f4e2f773b18cf535dc8fd18 251 PANTHER PTHR30292:SF0 1 251 6.9E-119 T 21-04-2016 SPH21_RS13440 93183f519f4e2f773b18cf535dc8fd18 251 Pfam PF03746 LamB/YcsF family 4 241 4.4E-99 T 21-04-2016 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 PANTHER PTHR22604 65 288 1.2E-145 T 21-04-2016 SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 PANTHER PTHR22604 309 464 1.2E-145 T 21-04-2016 SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 SUPERFAMILY SSF51735 69 229 1.21E-38 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 Gene3D G3DSA:3.40.50.720 407 431 2.6E-55 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 Gene3D G3DSA:3.40.50.720 71 235 2.6E-55 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 71 196 8.1E-18 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 PANTHER PTHR22604:SF2 65 288 1.2E-145 T 21-04-2016 SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 PANTHER PTHR22604:SF2 309 464 1.2E-145 T 21-04-2016 SPH21_RS01835 751d3fffc1ab0b082be13ad224b4dcbc 482 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 4 23 3.2E-4 T 21-04-2016 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SPH21_RS13330 f35a7efc42e2824a976cd9ac1c3bb85a 298 SUPERFAMILY SSF56059 97 269 3.28E-11 T 21-04-2016 SPH21_RS13330 f35a7efc42e2824a976cd9ac1c3bb85a 298 Gene3D G3DSA:3.30.470.20 198 269 2.1E-4 T 21-04-2016 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SPH21_RS20870 a653bf2c4adca957c5090ff301c49ecb 197 SUPERFAMILY SSF51206 3 140 1.7E-18 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS20870 a653bf2c4adca957c5090ff301c49ecb 197 Gene3D G3DSA:2.60.120.10 4 140 4.4E-23 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS06860 4a201bc503db67af356629f16f28e67d 129 Gene3D G3DSA:1.10.490.10 6 119 1.1E-15 T 21-04-2016 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 SPH21_RS06860 4a201bc503db67af356629f16f28e67d 129 SUPERFAMILY SSF46458 4 117 2.64E-21 T 21-04-2016 IPR009050 Globin-like SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 Gene3D G3DSA:2.130.10.130 481 596 2.1E-7 T 21-04-2016 SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 Gene3D G3DSA:2.130.10.130 297 480 2.4E-15 T 21-04-2016 SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 476 540 3.4E-10 T 21-04-2016 SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 311 375 8.6E-9 T 21-04-2016 SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 52 277 1.8E-11 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 PANTHER PTHR12121 45 284 1.6E-20 T 21-04-2016 SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 SUPERFAMILY SSF69318 418 600 2.09E-23 T 21-04-2016 SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 Gene3D G3DSA:3.60.10.10 49 284 1.0E-13 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 PANTHER PTHR12121:SF36 45 284 1.6E-20 T 21-04-2016 SPH21_RS10565 5c4105bccfc4fbebbb8664e068e2d4d4 613 SUPERFAMILY SSF56219 47 281 4.17E-30 T 21-04-2016 IPR005135 Endonuclease/exonuclease/phosphatase SPH21_RS24805 4c768cbba94fd49d24289e7a623c7d32 484 PANTHER PTHR11118:SF3 103 476 5.7E-131 T 21-04-2016 SPH21_RS24805 4c768cbba94fd49d24289e7a623c7d32 484 PANTHER PTHR11118 103 476 5.7E-131 T 21-04-2016 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 SPH21_RS24805 4c768cbba94fd49d24289e7a623c7d32 484 Pfam PF01139 tRNA-splicing ligase RtcB 113 473 1.3E-79 T 21-04-2016 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 SPH21_RS24805 4c768cbba94fd49d24289e7a623c7d32 484 SUPERFAMILY SSF103365 104 475 9.42E-102 T 21-04-2016 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 SPH21_RS00690 ec9f549fc330b9758b0c43525b81a9cd 242 PANTHER PTHR30269 1 239 4.8E-26 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS00690 ec9f549fc330b9758b0c43525b81a9cd 242 Pfam PF01925 Sulfite exporter TauE/SafE 6 237 5.2E-32 T 21-04-2016 IPR002781 Transmembrane protein TauE-like GO:0016021 SPH21_RS26200 48c13aa0aecae437ff0d14dc2d556336 329 Pfam PF02485 Core-2/I-Branching enzyme 7 246 1.5E-20 T 21-04-2016 IPR003406 Glycosyl transferase, family 14 GO:0008375|GO:0016020 SPH21_RS26200 48c13aa0aecae437ff0d14dc2d556336 329 PANTHER PTHR19297 194 243 8.8E-15 T 21-04-2016 SPH21_RS26200 48c13aa0aecae437ff0d14dc2d556336 329 PANTHER PTHR19297 2 164 8.8E-15 T 21-04-2016 SPH21_RS26200 48c13aa0aecae437ff0d14dc2d556336 329 PANTHER PTHR19297:SF108 194 243 8.8E-15 T 21-04-2016 SPH21_RS26200 48c13aa0aecae437ff0d14dc2d556336 329 PANTHER PTHR19297:SF108 2 164 8.8E-15 T 21-04-2016 SPH21_RS22380 04b39eafbc027d9eb0d7325b228f75c6 280 Gene3D G3DSA:1.10.3720.10 14 279 4.0E-37 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS22380 04b39eafbc027d9eb0d7325b228f75c6 280 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 85 275 2.3E-18 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS22380 04b39eafbc027d9eb0d7325b228f75c6 280 SUPERFAMILY SSF161098 12 271 3.14E-34 T 21-04-2016 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SPH21_RS22380 04b39eafbc027d9eb0d7325b228f75c6 280 PANTHER PTHR30425 1 279 8.9E-66 T 21-04-2016 SPH21_RS24900 2bb75ea32d12b0e07060c299d93d7808 305 PANTHER PTHR36838 3 305 1.2E-20 T 21-04-2016 SPH21_RS24900 2bb75ea32d12b0e07060c299d93d7808 305 Pfam PF03547 Membrane transport protein 8 143 2.7E-7 T 21-04-2016 IPR004776 Auxin efflux carrier GO:0016021|GO:0055085 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 Pfam PF00902 Sec-independent protein translocase protein (TatC) 28 263 3.0E-63 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PANTHER PTHR30371:SF0 93 288 3.1E-71 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PANTHER PTHR30371:SF0 1 73 3.1E-71 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 TIGRFAM TIGR00945 tatC: twin arginine-targeting protein translocase TatC 26 268 7.4E-49 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 Hamap MF_00902 Sec-independent protein translocase protein TatC [tatC]. 14 282 18.853 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 125 143 2.5E-30 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 195 223 2.5E-30 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 25 52 2.5E-30 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 143 169 2.5E-30 T 21-04-2016 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PANTHER PTHR30371 93 288 3.1E-71 T 21-04-2016 SPH21_RS00070 54261c810147b36ec1da9276e92c3d7c 294 PANTHER PTHR30371 1 73 3.1E-71 T 21-04-2016 SPH21_RS00885 46447542090fe5245171f935820b5f47 441 PANTHER PTHR34219 117 412 7.1E-60 T 21-04-2016 SPH21_RS00885 46447542090fe5245171f935820b5f47 441 PANTHER PTHR34219 9 101 7.1E-60 T 21-04-2016 SPH21_RS00885 46447542090fe5245171f935820b5f47 441 Pfam PF03929 PepSY-associated TM region 21 408 9.3E-61 T 21-04-2016 IPR005625 PepSY-associated TM protein SPH21_RS23705 841fb4e6169c019d95d21ee0f03ce49f 124 Pfam PF01850 PIN domain 6 115 7.4E-8 T 21-04-2016 IPR002716 PIN domain SPH21_RS23705 841fb4e6169c019d95d21ee0f03ce49f 124 PANTHER PTHR33653:SF1 1 123 1.0E-11 T 21-04-2016 SPH21_RS23705 841fb4e6169c019d95d21ee0f03ce49f 124 SUPERFAMILY SSF88723 1 122 1.01E-21 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS23705 841fb4e6169c019d95d21ee0f03ce49f 124 Gene3D G3DSA:3.40.50.1010 3 122 2.0E-22 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS23705 841fb4e6169c019d95d21ee0f03ce49f 124 PANTHER PTHR33653 1 123 1.0E-11 T 21-04-2016 SPH21_RS16560 c9c0f3a6ed05bf8101a0dc60d3db0e4d 375 PANTHER PTHR36174 64 364 1.1E-32 T 21-04-2016 SPH21_RS16560 c9c0f3a6ed05bf8101a0dc60d3db0e4d 375 SUPERFAMILY SSF55729 182 364 1.97E-36 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS16560 c9c0f3a6ed05bf8101a0dc60d3db0e4d 375 Pfam PF02388 FemAB family 263 364 1.6E-26 T 21-04-2016 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 SPH21_RS16560 c9c0f3a6ed05bf8101a0dc60d3db0e4d 375 Pfam PF02388 FemAB family 17 247 2.7E-19 T 21-04-2016 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 SPH21_RS16560 c9c0f3a6ed05bf8101a0dc60d3db0e4d 375 PANTHER PTHR36174:SF1 64 364 1.1E-32 T 21-04-2016 SPH21_RS16560 c9c0f3a6ed05bf8101a0dc60d3db0e4d 375 Gene3D G3DSA:3.40.630.30 143 349 4.5E-61 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS12010 479cf002e90528e03fa0cbc768756823 370 PANTHER PTHR12526 1 370 5.4E-64 T 21-04-2016 SPH21_RS12010 479cf002e90528e03fa0cbc768756823 370 Pfam PF00534 Glycosyl transferases group 1 197 348 1.2E-25 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS12010 479cf002e90528e03fa0cbc768756823 370 Pfam PF13439 Glycosyltransferase Family 4 16 171 1.7E-13 T 21-04-2016 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain SPH21_RS12010 479cf002e90528e03fa0cbc768756823 370 PANTHER PTHR12526:SF399 1 370 5.4E-64 T 21-04-2016 SPH21_RS12010 479cf002e90528e03fa0cbc768756823 370 SUPERFAMILY SSF53756 13 370 1.17E-66 T 21-04-2016 SPH21_RS12010 479cf002e90528e03fa0cbc768756823 370 Gene3D G3DSA:3.40.50.2000 162 347 3.7E-22 T 21-04-2016 SPH21_RS04630 863691d461fa839ad2d4f3d475bf194c 372 PANTHER PTHR33886 164 364 4.3E-42 T 21-04-2016 SPH21_RS04630 863691d461fa839ad2d4f3d475bf194c 372 Gene3D G3DSA:1.50.10.10 28 367 2.3E-80 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS04630 863691d461fa839ad2d4f3d475bf194c 372 PANTHER PTHR33886:SF2 164 364 4.3E-42 T 21-04-2016 SPH21_RS04630 863691d461fa839ad2d4f3d475bf194c 372 SUPERFAMILY SSF48208 56 368 1.01E-51 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS04630 863691d461fa839ad2d4f3d475bf194c 372 Pfam PF07470 Glycosyl Hydrolase Family 88 59 366 3.8E-62 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS26255 7fcfa3f8c8e8b27d0840ebc1ecd5b764 713 Gene3D G3DSA:2.40.10.10 89 171 1.3E-11 T 21-04-2016 SPH21_RS26255 7fcfa3f8c8e8b27d0840ebc1ecd5b764 713 Pfam PF13365 Trypsin-like peptidase domain 106 259 5.5E-17 T 21-04-2016 SPH21_RS26255 7fcfa3f8c8e8b27d0840ebc1ecd5b764 713 Gene3D G3DSA:2.40.10.10 172 278 2.0E-16 T 21-04-2016 SPH21_RS26255 7fcfa3f8c8e8b27d0840ebc1ecd5b764 713 SUPERFAMILY SSF50494 83 264 1.11E-26 T 21-04-2016 IPR009003 Peptidase S1, PA clan SPH21_RS26255 7fcfa3f8c8e8b27d0840ebc1ecd5b764 713 SUPERFAMILY SSF54060 450 602 1.65E-33 T 21-04-2016 SPH21_RS26255 7fcfa3f8c8e8b27d0840ebc1ecd5b764 713 PANTHER PTHR33607 464 609 2.9E-28 T 21-04-2016 SPH21_RS26255 7fcfa3f8c8e8b27d0840ebc1ecd5b764 713 Pfam PF04231 Endonuclease I 458 602 2.3E-26 T 21-04-2016 IPR007346 Endonuclease I GO:0004518 SPH21_RS02620 1e090cc4c1785e26c8a00ca9e9727dd0 393 SUPERFAMILY SSF109604 8 193 2.4E-32 T 21-04-2016 SPH21_RS02620 1e090cc4c1785e26c8a00ca9e9727dd0 393 Pfam PF01966 HD domain 31 130 1.6E-8 T 21-04-2016 IPR006674 HD domain SPH21_RS02620 1e090cc4c1785e26c8a00ca9e9727dd0 393 Gene3D G3DSA:1.10.3210.10 4 128 7.8E-22 T 21-04-2016 IPR006674 HD domain SPH21_RS02620 1e090cc4c1785e26c8a00ca9e9727dd0 393 SMART SM00471 26 141 0.001 T 21-04-2016 IPR003607 HD/PDEase domain SPH21_RS13110 b114c7d409c3121ce8b8d10d61eb95e2 512 SUPERFAMILY SSF48452 20 511 1.77E-104 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13110 b114c7d409c3121ce8b8d10d61eb95e2 512 Pfam PF12771 Starch-binding associating with outer membrane 2 509 1.1E-48 T 21-04-2016 SPH21_RS13110 b114c7d409c3121ce8b8d10d61eb95e2 512 PANTHER PTHR35148 1 299 1.3E-57 T 21-04-2016 SPH21_RS13110 b114c7d409c3121ce8b8d10d61eb95e2 512 PANTHER PTHR35148 316 512 1.3E-57 T 21-04-2016 SPH21_RS18955 956fd20bb74c48dcb251ca36f518a68e 264 SUPERFAMILY SSF52402 5 130 1.34E-8 T 21-04-2016 SPH21_RS18955 956fd20bb74c48dcb251ca36f518a68e 264 Gene3D G3DSA:3.40.50.620 123 241 3.9E-5 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS18955 956fd20bb74c48dcb251ca36f518a68e 264 Gene3D G3DSA:3.40.50.620 5 122 1.4E-7 T 21-04-2016 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SPH21_RS13650 e62bdd7dec29871a5be072a59d367f46 166 PANTHER PTHR13947 13 159 1.2E-28 T 21-04-2016 SPH21_RS13650 e62bdd7dec29871a5be072a59d367f46 166 PANTHER PTHR13947:SF16 13 159 1.2E-28 T 21-04-2016 SPH21_RS13650 e62bdd7dec29871a5be072a59d367f46 166 Pfam PF00583 Acetyltransferase (GNAT) family 63 137 2.3E-12 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS13650 e62bdd7dec29871a5be072a59d367f46 166 SUPERFAMILY SSF55729 12 146 1.49E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS13650 e62bdd7dec29871a5be072a59d367f46 166 Gene3D G3DSA:3.40.630.30 3 151 7.1E-28 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS20950 8b624e9d8ae960d43c07e11e9d32d4d5 185 PANTHER PTHR24567 20 182 3.2E-26 T 21-04-2016 SPH21_RS20950 8b624e9d8ae960d43c07e11e9d32d4d5 185 SUPERFAMILY SSF51206 13 132 3.27E-18 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS20950 8b624e9d8ae960d43c07e11e9d32d4d5 185 Gene3D G3DSA:2.60.120.10 10 147 2.3E-30 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS20950 8b624e9d8ae960d43c07e11e9d32d4d5 185 PANTHER PTHR24567:SF33 20 182 3.2E-26 T 21-04-2016 SPH21_RS20950 8b624e9d8ae960d43c07e11e9d32d4d5 185 Pfam PF00027 Cyclic nucleotide-binding domain 22 108 2.9E-9 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 TIGRFAM TIGR04056 OMP_RagA_SusC: TonB-linked outer membrane protein, SusC/RagA family 48 1011 3.0E-268 T 21-04-2016 IPR023996 TonB-dependent outer membrane protein, SusC/RagA UniPathway: UPA00153 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 Gene3D G3DSA:2.60.40.1120 50 140 8.0E-14 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 PANTHER PTHR11532 45 384 5.7E-243 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 PANTHER PTHR11532 477 546 5.7E-243 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 PANTHER PTHR11532 573 1009 5.7E-243 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 SUPERFAMILY SSF49464 48 130 7.85E-16 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 Gene3D G3DSA:2.40.170.20 927 978 6.2E-37 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 Gene3D G3DSA:2.40.170.20 846 891 6.2E-37 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 Gene3D G3DSA:2.40.170.20 337 785 6.2E-37 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 Gene3D G3DSA:2.170.130.10 141 258 9.1E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 TIGRFAM TIGR04057 SusC_RagA_signa: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region 225 255 1.7E-19 T 21-04-2016 IPR023997 TonB-dependent outer membrane protein SusC/RagA, conserved site UniPathway: UPA00153 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 Pfam PF13715 CarboxypepD_reg-like domain 50 132 1.0E-16 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 Pfam PF07715 TonB-dependent Receptor Plug Domain 139 249 7.5E-22 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 PANTHER PTHR11532:SF57 45 384 5.7E-243 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 PANTHER PTHR11532:SF57 477 546 5.7E-243 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 PANTHER PTHR11532:SF57 573 1009 5.7E-243 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 SUPERFAMILY SSF56935 852 896 4.07E-100 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 SUPERFAMILY SSF56935 128 273 4.07E-100 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 SUPERFAMILY SSF56935 446 785 4.07E-100 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 SUPERFAMILY SSF56935 330 418 4.07E-100 T 21-04-2016 SPH21_RS21045 b4b250ae8ec4fb8448884f5a59d698ed 1011 SUPERFAMILY SSF56935 929 1011 4.07E-100 T 21-04-2016 SPH21_RS05745 f6119c87a3f2370fb1dd815cefe3dfb3 240 Pfam PF04029 2-phosphosulpholactate phosphatase 12 231 1.2E-80 T 21-04-2016 IPR005238 ComB-like GO:0000287|GO:0050532 KEGG: 00680+3.1.3.71 SPH21_RS05745 f6119c87a3f2370fb1dd815cefe3dfb3 240 PANTHER PTHR37311:SF1 4 237 1.6E-49 T 21-04-2016 SPH21_RS05745 f6119c87a3f2370fb1dd815cefe3dfb3 240 SUPERFAMILY SSF142823 7 235 2.75E-69 T 21-04-2016 IPR005238 ComB-like GO:0000287|GO:0050532 KEGG: 00680+3.1.3.71 SPH21_RS05745 f6119c87a3f2370fb1dd815cefe3dfb3 240 PANTHER PTHR37311 4 237 1.6E-49 T 21-04-2016 SPH21_RS05745 f6119c87a3f2370fb1dd815cefe3dfb3 240 Hamap MF_00490 2-phosphosulfolactate phosphatase [comB]. 10 239 28.609 T 21-04-2016 IPR022995 Probable 2-phosphosulpholactate phosphatase GO:0019295|GO:0050532 KEGG: 00680+3.1.3.71 SPH21_RS05745 f6119c87a3f2370fb1dd815cefe3dfb3 240 Gene3D G3DSA:3.90.1560.10 17 237 1.1E-77 T 21-04-2016 IPR005238 ComB-like GO:0000287|GO:0050532 KEGG: 00680+3.1.3.71 SPH21_RS14010 45b7621fe4fd8fc11367803ede9d2917 240 Pfam PF13649 Methyltransferase domain 58 156 3.8E-19 T 21-04-2016 SPH21_RS14010 45b7621fe4fd8fc11367803ede9d2917 240 SUPERFAMILY SSF53335 195 227 5.06E-33 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS14010 45b7621fe4fd8fc11367803ede9d2917 240 SUPERFAMILY SSF53335 12 167 5.06E-33 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS14010 45b7621fe4fd8fc11367803ede9d2917 240 Gene3D G3DSA:3.40.50.150 12 238 5.7E-33 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS14010 45b7621fe4fd8fc11367803ede9d2917 240 PANTHER PTHR10108 53 226 2.5E-19 T 21-04-2016 SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 PANTHER PTHR32309:SF13 183 773 6.2E-154 T 21-04-2016 SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 PANTHER PTHR32309:SF13 11 124 6.2E-154 T 21-04-2016 SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 TIGRFAM TIGR01007 eps_fam: capsular exopolysaccharide family 557 763 1.1E-43 T 21-04-2016 IPR005702 Exopolysaccharide synthesis protein GO:0045226 SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 Pfam PF13807 G-rich domain on putative tyrosine kinase 432 511 6.4E-16 T 21-04-2016 IPR032807 Tyrosine kinase, G-rich domain SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 SUPERFAMILY SSF52540 576 752 3.04E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 Pfam PF02706 Chain length determinant protein 14 144 2.8E-9 T 21-04-2016 IPR003856 Lipopolysaccharide biosynthesis GO:0009103|GO:0016020 SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 Gene3D G3DSA:3.40.50.300 575 755 1.7E-26 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 PANTHER PTHR32309 183 773 6.2E-154 T 21-04-2016 SPH21_RS08955 99c1e76309d5f1bd1e1d91337f01b735 789 PANTHER PTHR32309 11 124 6.2E-154 T 21-04-2016 SPH21_RS04885 ffdddd3e9b122db28b07e3db092305a3 583 Pfam PF05960 Bacterial protein of unknown function (DUF885) 71 563 1.5E-65 T 21-04-2016 IPR010281 Protein of unknown function DUF885 SPH21_RS09645 040b0cb9949c6b10df8b90f382a49a1e 386 PANTHER PTHR12526 4 383 4.1E-26 T 21-04-2016 SPH21_RS09645 040b0cb9949c6b10df8b90f382a49a1e 386 Pfam PF00534 Glycosyl transferases group 1 209 364 2.6E-21 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS09645 040b0cb9949c6b10df8b90f382a49a1e 386 Gene3D G3DSA:3.40.50.2000 206 334 1.2E-14 T 21-04-2016 SPH21_RS09645 040b0cb9949c6b10df8b90f382a49a1e 386 SUPERFAMILY SSF53756 5 383 4.93E-43 T 21-04-2016 SPH21_RS21305 c3d7ba07571ed1c2762f66f28871b266 550 Gene3D G3DSA:2.80.10.50 42 193 3.4E-20 T 21-04-2016 SPH21_RS21305 c3d7ba07571ed1c2762f66f28871b266 550 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 87 180 1.2E-17 T 21-04-2016 IPR000772 Ricin B, lectin domain SPH21_RS21305 c3d7ba07571ed1c2762f66f28871b266 550 Gene3D G3DSA:2.115.10.20 372 485 9.1E-7 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS21305 c3d7ba07571ed1c2762f66f28871b266 550 SUPERFAMILY SSF50370 40 193 3.8E-26 T 21-04-2016 IPR000772 Ricin B, lectin domain SPH21_RS21305 c3d7ba07571ed1c2762f66f28871b266 550 SUPERFAMILY SSF75005 306 514 1.15E-7 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS19845 3800b0b2f2bcfc8efd32db1caf95326a 194 PANTHER PTHR14969 1 183 3.2E-19 T 21-04-2016 SPH21_RS19845 3800b0b2f2bcfc8efd32db1caf95326a 194 Pfam PF01569 PAP2 superfamily 63 179 2.2E-21 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS19845 3800b0b2f2bcfc8efd32db1caf95326a 194 Gene3D G3DSA:1.20.144.10 5 182 3.6E-30 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS19845 3800b0b2f2bcfc8efd32db1caf95326a 194 SMART SM00014 58 177 2.6E-15 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS19845 3800b0b2f2bcfc8efd32db1caf95326a 194 SUPERFAMILY SSF48317 5 185 3.92E-31 T 21-04-2016 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SPH21_RS06650 9e362d2f43585b48d05c8dbe96ec2ab9 548 PANTHER PTHR33885 69 351 1.1E-16 T 21-04-2016 SPH21_RS06650 9e362d2f43585b48d05c8dbe96ec2ab9 548 Pfam PF04024 PspC domain 111 167 8.0E-22 T 21-04-2016 IPR007168 Phage shock protein, PspC, N-terminal SPH21_RS01510 695ad4e973738cd83a7fb569c0aab284 413 Pfam PF00589 Phage integrase family 223 387 5.6E-17 T 21-04-2016 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS01510 695ad4e973738cd83a7fb569c0aab284 413 Pfam PF13102 Phage integrase SAM-like domain 10 174 2.3E-20 T 21-04-2016 IPR025269 Phage integrase SAM-like domain SPH21_RS01510 695ad4e973738cd83a7fb569c0aab284 413 PANTHER PTHR30349 40 402 1.6E-85 T 21-04-2016 SPH21_RS01510 695ad4e973738cd83a7fb569c0aab284 413 PANTHER PTHR30349:SF26 40 402 1.6E-85 T 21-04-2016 SPH21_RS01510 695ad4e973738cd83a7fb569c0aab284 413 Gene3D G3DSA:1.10.443.10 219 400 3.7E-32 T 21-04-2016 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SPH21_RS01510 695ad4e973738cd83a7fb569c0aab284 413 SUPERFAMILY SSF56349 121 391 4.71E-46 T 21-04-2016 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SPH21_RS01510 695ad4e973738cd83a7fb569c0aab284 413 Gene3D G3DSA:1.10.150.130 125 209 2.0E-5 T 21-04-2016 IPR023109 Integrase/recombinase, N-terminal SPH21_RS14645 cf2bd09efd758c64555e0302b1eb3b69 242 Pfam PF02754 Cysteine-rich domain 3 83 1.8E-14 T 21-04-2016 IPR004017 Cysteine-rich domain SPH21_RS14645 cf2bd09efd758c64555e0302b1eb3b69 242 Pfam PF02754 Cysteine-rich domain 132 216 1.5E-16 T 21-04-2016 IPR004017 Cysteine-rich domain SPH21_RS14645 cf2bd09efd758c64555e0302b1eb3b69 242 PANTHER PTHR30296:SF0 2 242 5.5E-86 T 21-04-2016 SPH21_RS14645 cf2bd09efd758c64555e0302b1eb3b69 242 PANTHER PTHR30296 2 242 5.5E-86 T 21-04-2016 SPH21_RS07560 31382ff38146da08c0dac9ceb7f58e75 63 Pfam PF09957 Bacterial antitoxin of type II TA system, VapB 1 45 2.9E-18 T 21-04-2016 IPR019239 Bacterial antitoxin of type II TA system, VapB SPH21_RS18910 97630ba37566cc8f9beb94440f1c4cc7 245 Pfam PF01904 Protein of unknown function DUF72 25 242 8.4E-66 T 21-04-2016 IPR002763 Protein of unknown function DUF72 SPH21_RS18910 97630ba37566cc8f9beb94440f1c4cc7 245 Gene3D G3DSA:3.20.20.410 5 243 1.9E-79 T 21-04-2016 IPR002763 Protein of unknown function DUF72 SPH21_RS18910 97630ba37566cc8f9beb94440f1c4cc7 245 PANTHER PTHR30348 9 242 5.0E-76 T 21-04-2016 SPH21_RS18910 97630ba37566cc8f9beb94440f1c4cc7 245 SUPERFAMILY SSF117396 9 243 2.35E-79 T 21-04-2016 IPR002763 Protein of unknown function DUF72 SPH21_RS26240 0a8448fae2613ec999b00d85fc48dddd 429 SUPERFAMILY SSF69318 139 403 1.13E-19 T 21-04-2016 SPH21_RS26240 0a8448fae2613ec999b00d85fc48dddd 429 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 150 208 8.0E-8 T 21-04-2016 SPH21_RS01415 8f3def53810476e712fa57c16c59a1b7 208 Pfam PF11827 Protein of unknown function (DUF3347) 15 204 4.7E-55 T 21-04-2016 IPR021782 Protein of unknown function DUF3347 SPH21_RS15140 275db4dfaeba6f101ea121d3a69995ce 359 Pfam PF12725 Protein of unknown function (DUF3810) 36 349 8.6E-88 T 21-04-2016 IPR024294 Protein of unknown function DUF3810 SPH21_RS06990 b94f8df088890cd97681ff2c88f848d9 508 Pfam PF07980 SusD family 277 508 9.7E-32 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS06990 b94f8df088890cd97681ff2c88f848d9 508 SUPERFAMILY SSF48452 21 508 2.4E-115 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06990 b94f8df088890cd97681ff2c88f848d9 508 Gene3D G3DSA:1.25.40.10 215 454 7.2E-38 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06990 b94f8df088890cd97681ff2c88f848d9 508 Pfam PF14322 Starch-binding associating with outer membrane 48 234 1.2E-18 T 21-04-2016 SPH21_RS02175 0be3f9bdb75f92423ee64fcfb26c50c9 117 Gene3D G3DSA:1.10.260.40 47 114 5.6E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS02175 0be3f9bdb75f92423ee64fcfb26c50c9 117 PANTHER PTHR40455:SF1 1 117 4.1E-13 T 21-04-2016 SPH21_RS02175 0be3f9bdb75f92423ee64fcfb26c50c9 117 SUPERFAMILY SSF47413 58 114 2.08E-7 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS02175 0be3f9bdb75f92423ee64fcfb26c50c9 117 PANTHER PTHR40455 1 117 4.1E-13 T 21-04-2016 SPH21_RS22600 fbe1a1f29dc6743503d79396f5c65abd 416 Gene3D G3DSA:2.120.10.30 16 22 1.5E-101 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS22600 fbe1a1f29dc6743503d79396f5c65abd 416 Gene3D G3DSA:2.120.10.30 64 411 1.5E-101 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS22600 fbe1a1f29dc6743503d79396f5c65abd 416 Pfam PF07995 Glucose / Sorbosone dehydrogenase 79 405 1.1E-126 T 21-04-2016 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SPH21_RS22600 fbe1a1f29dc6743503d79396f5c65abd 416 SUPERFAMILY SSF50952 60 404 1.57E-46 T 21-04-2016 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SPH21_RS22600 fbe1a1f29dc6743503d79396f5c65abd 416 PANTHER PTHR19328 79 406 4.1E-68 T 21-04-2016 SPH21_RS04160 86c5073b854a317caac3ebb9b4215435 256 Gene3D G3DSA:1.10.10.60 218 250 1.1E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04160 86c5073b854a317caac3ebb9b4215435 256 Gene3D G3DSA:1.10.10.60 156 207 6.8E-9 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS04160 86c5073b854a317caac3ebb9b4215435 256 SMART SM00342 169 250 5.4E-10 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS04160 86c5073b854a317caac3ebb9b4215435 256 PANTHER PTHR11019:SF126 125 249 8.2E-17 T 21-04-2016 SPH21_RS04160 86c5073b854a317caac3ebb9b4215435 256 PANTHER PTHR11019 125 249 8.2E-17 T 21-04-2016 SPH21_RS04160 86c5073b854a317caac3ebb9b4215435 256 Pfam PF12833 Helix-turn-helix domain 175 251 4.1E-14 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 Pfam PF01252 Signal peptidase (SPase) II 11 194 1.6E-31 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 Hamap MF_00161 Lipoprotein signal peptidase [lspA]. 2 202 13.094 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PANTHER PTHR33695:SF1 8 113 1.6E-32 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PANTHER PTHR33695:SF1 141 159 1.6E-32 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PANTHER PTHR33695:SF1 176 212 1.6E-32 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PANTHER PTHR33695 8 113 1.6E-32 T 21-04-2016 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PANTHER PTHR33695 141 159 1.6E-32 T 21-04-2016 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PANTHER PTHR33695 176 212 1.6E-32 T 21-04-2016 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 98 113 3.3E-14 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 177 193 3.3E-14 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS00220 e4e29dcf1e7902675e8cd5fa739a8660 216 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 49 57 3.3E-14 T 21-04-2016 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 UniPathway: UPA00665 SPH21_RS05685 7514948f23ff19602d8f72da3ad1f709 126 Pfam PF01042 Endoribonuclease L-PSP 8 123 6.8E-43 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS05685 7514948f23ff19602d8f72da3ad1f709 126 TIGRFAM TIGR00004 TIGR00004: reactive intermediate/imine deaminase 2 124 1.9E-50 T 21-04-2016 IPR006056 RidA family SPH21_RS05685 7514948f23ff19602d8f72da3ad1f709 126 Gene3D G3DSA:3.30.1330.40 1 124 9.6E-50 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS05685 7514948f23ff19602d8f72da3ad1f709 126 PANTHER PTHR11803 1 124 1.3E-55 T 21-04-2016 IPR006175 YjgF/YER057c/UK114 family SPH21_RS05685 7514948f23ff19602d8f72da3ad1f709 126 SUPERFAMILY SSF55298 1 125 4.71E-47 T 21-04-2016 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SPH21_RS06585 f6db84de05fdfca2fcacfcb506a1871a 253 SUPERFAMILY SSF102110 6 247 2.88E-83 T 21-04-2016 IPR003830 (2R)-phospho-3-sulpholactate synthase, ComA KEGG: 00680+4.4.1.19 SPH21_RS06585 f6db84de05fdfca2fcacfcb506a1871a 253 Pfam PF02679 (2R)-phospho-3-sulfolactate synthase (ComA) 11 245 6.1E-86 T 21-04-2016 IPR003830 (2R)-phospho-3-sulpholactate synthase, ComA KEGG: 00680+4.4.1.19 SPH21_RS06585 f6db84de05fdfca2fcacfcb506a1871a 253 Gene3D G3DSA:3.20.20.70 9 248 3.6E-81 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS03320 a6ee439898aa05e5815e691782d80db8 122 PANTHER PTHR34039:SF1 1 121 1.4E-38 T 21-04-2016 SPH21_RS03320 a6ee439898aa05e5815e691782d80db8 122 PANTHER PTHR34039 1 121 1.4E-38 T 21-04-2016 SPH21_RS03320 a6ee439898aa05e5815e691782d80db8 122 Hamap MF_00048 UPF0102 protein YraN [yraN]. 4 113 20.855 T 21-04-2016 IPR003509 Uncharacterised protein family UPF0102 SPH21_RS03320 a6ee439898aa05e5815e691782d80db8 122 TIGRFAM TIGR00252 TIGR00252: TIGR00252 family protein 7 117 2.1E-24 T 21-04-2016 IPR003509 Uncharacterised protein family UPF0102 SPH21_RS03320 a6ee439898aa05e5815e691782d80db8 122 SUPERFAMILY SSF52980 11 105 1.72E-22 T 21-04-2016 IPR011335 Restriction endonuclease type II-like SPH21_RS03320 a6ee439898aa05e5815e691782d80db8 122 Gene3D G3DSA:3.40.1350.10 11 118 4.3E-34 T 21-04-2016 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 SPH21_RS03320 a6ee439898aa05e5815e691782d80db8 122 Pfam PF02021 Uncharacterised protein family UPF0102 11 100 4.4E-27 T 21-04-2016 IPR003509 Uncharacterised protein family UPF0102 SPH21_RS03580 7143fb08904ef72c7aae321808ddfe52 432 PANTHER PTHR36845:SF1 85 421 3.0E-73 T 21-04-2016 SPH21_RS03580 7143fb08904ef72c7aae321808ddfe52 432 PANTHER PTHR36845 85 421 3.0E-73 T 21-04-2016 SPH21_RS03580 7143fb08904ef72c7aae321808ddfe52 432 Pfam PF07470 Glycosyl Hydrolase Family 88 88 416 1.5E-22 T 21-04-2016 IPR010905 Glycosyl hydrolase, family 88 SPH21_RS03580 7143fb08904ef72c7aae321808ddfe52 432 SUPERFAMILY SSF48208 69 417 4.86E-89 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS03580 7143fb08904ef72c7aae321808ddfe52 432 Gene3D G3DSA:1.50.10.10 55 418 2.1E-124 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS18105 dc25e251e9ecd118a378d04e3a807203 143 PANTHER PTHR36919 4 142 1.1E-27 T 21-04-2016 SPH21_RS18105 dc25e251e9ecd118a378d04e3a807203 143 Pfam PF09917 Uncharacterized protein conserved in bacteria (DUF2147) 27 141 4.0E-36 T 21-04-2016 IPR019223 Domain of unknown function DUF2147 SPH21_RS18475 7e4088b45667a59cf0472de393519270 443 SUPERFAMILY SSF52777 12 155 7.0E-14 T 21-04-2016 SPH21_RS18475 7e4088b45667a59cf0472de393519270 443 Pfam PF00668 Condensation domain 28 162 1.2E-9 T 21-04-2016 IPR001242 Condensation domain SPH21_RS18475 7e4088b45667a59cf0472de393519270 443 SUPERFAMILY SSF52777 222 417 5.34E-7 T 21-04-2016 SPH21_RS23430 27654621be3d49d8dc318b7f5cb2fc8a 189 Pfam PF04224 Protein of unknown function, DUF417 4 186 2.8E-70 T 21-04-2016 IPR007339 Protein of unknown function DUF417 SPH21_RS23430 27654621be3d49d8dc318b7f5cb2fc8a 189 PANTHER PTHR40106 1 186 1.9E-53 T 21-04-2016 SPH21_RS23430 27654621be3d49d8dc318b7f5cb2fc8a 189 PANTHER PTHR40106:SF1 1 186 1.9E-53 T 21-04-2016 SPH21_RS08030 063bf976dcf7a4f02b1bf084c775f4f4 94 Pfam PF16118 Domain of unknown function (DUF4834) 2 94 3.9E-9 T 21-04-2016 IPR032272 Protein of unknown function DUF4834 SPH21_RS09780 9f0c8e5056da3e160eeb8b6a79ffdae5 385 Pfam PF03929 PepSY-associated TM region 9 364 2.2E-64 T 21-04-2016 IPR005625 PepSY-associated TM protein SPH21_RS09780 9f0c8e5056da3e160eeb8b6a79ffdae5 385 PANTHER PTHR34219 1 369 1.8E-57 T 21-04-2016 SPH21_RS13945 7a52a588f88366e1e6c0ee1672a515d9 434 Pfam PF02321 Outer membrane efflux protein 46 229 1.0E-13 T 21-04-2016 IPR003423 Outer membrane efflux protein GO:0005215|GO:0006810 SPH21_RS13945 7a52a588f88366e1e6c0ee1672a515d9 434 Gene3D G3DSA:1.20.1600.10 39 432 6.1E-25 T 21-04-2016 SPH21_RS13945 7a52a588f88366e1e6c0ee1672a515d9 434 SUPERFAMILY SSF56954 17 430 1.96E-38 T 21-04-2016 SPH21_RS07090 bf134d07648e7ee4b4d96e4b4b3e00e2 580 Pfam PF13320 Domain of unknown function (DUF4091) 475 533 1.1E-17 T 21-04-2016 IPR025150 Domain of unknown function DUF4091 SPH21_RS07090 bf134d07648e7ee4b4d96e4b4b3e00e2 580 Gene3D G3DSA:3.20.20.80 246 431 4.7E-4 T 21-04-2016 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SPH21_RS13185 8bc5567664a945951c8c7fca7976c213 518 Gene3D G3DSA:1.25.40.10 203 316 1.4E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13185 8bc5567664a945951c8c7fca7976c213 518 Gene3D G3DSA:1.25.40.10 365 462 1.4E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13185 8bc5567664a945951c8c7fca7976c213 518 Pfam PF14322 Starch-binding associating with outer membrane 41 222 9.0E-26 T 21-04-2016 SPH21_RS13185 8bc5567664a945951c8c7fca7976c213 518 Pfam PF07980 SusD family 264 518 7.6E-34 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13185 8bc5567664a945951c8c7fca7976c213 518 SUPERFAMILY SSF48452 21 518 4.3E-106 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS24885 9e147462629d7c2001d8eeeab310f1c5 239 Pfam PF13030 Protein of unknown function (DUF3891) 1 210 4.6E-55 T 21-04-2016 IPR024992 Protein of unknown function DUF3891 SPH21_RS18470 4964e50d3eb093ea8c908de0d4b65032 432 SUPERFAMILY SSF52777 6 149 7.56E-17 T 21-04-2016 SPH21_RS18470 4964e50d3eb093ea8c908de0d4b65032 432 SUPERFAMILY SSF52777 205 414 2.11E-7 T 21-04-2016 SPH21_RS18470 4964e50d3eb093ea8c908de0d4b65032 432 Pfam PF00668 Condensation domain 18 241 5.1E-13 T 21-04-2016 IPR001242 Condensation domain SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 ProSitePatterns PS00585 Ribosomal protein S5 signature. 33 65 - T 21-04-2016 IPR018192 Ribosomal protein S5, N-terminal, conserved site SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 Pfam PF03719 Ribosomal protein S5, C-terminal domain 92 162 1.2E-28 T 21-04-2016 IPR005324 Ribosomal protein S5, C-terminal GO:0003735|GO:0005840|GO:0006412 SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 Gene3D G3DSA:3.30.230.10 83 163 4.8E-31 T 21-04-2016 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 Hamap MF_01307_B 30S ribosomal protein S5 [rpsE]. 6 168 33.608 T 21-04-2016 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 Gene3D G3DSA:3.30.160.20 15 78 6.9E-30 T 21-04-2016 IPR014720 Double-stranded RNA-binding domain SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 SUPERFAMILY SSF54211 84 163 3.54E-25 T 21-04-2016 IPR020568 Ribosomal protein S5 domain 2-type fold SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 SUPERFAMILY SSF54768 15 81 3.77E-22 T 21-04-2016 SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 TIGRFAM TIGR01021 rpsE_bact: ribosomal protein uS5 15 167 5.1E-63 T 21-04-2016 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 Pfam PF00333 Ribosomal protein S5, N-terminal domain 16 80 2.4E-29 T 21-04-2016 IPR013810 Ribosomal protein S5, N-terminal GO:0003723|GO:0003735|GO:0005840|GO:0006412 SPH21_RS08580 e46dffb12334d645f95716556f66bc73 172 PANTHER PTHR13718 9 163 1.1E-62 T 21-04-2016 IPR000851 Ribosomal protein S5 GO:0003735|GO:0005840|GO:0006412 SPH21_RS07755 3a9a30308c0def0faad6d48c474e3dfc 109 Pfam PF14114 Domain of unknown function (DUF4286) 12 106 1.0E-19 T 21-04-2016 IPR025563 Protein of unknown function DUF4286 SPH21_RS11700 096ac0f553b8fa788a4bbf5b198837fe 430 Pfam PF16871 Domain of unknown function (DUF5077) 37 223 3.9E-66 T 21-04-2016 IPR031712 Domain of unknown function DUF5077 SPH21_RS11700 096ac0f553b8fa788a4bbf5b198837fe 430 Pfam PF11958 Domain of unknown function (DUF3472) 229 401 2.7E-71 T 21-04-2016 IPR021862 Protein of unknown function DUF3472 SPH21_RS11700 096ac0f553b8fa788a4bbf5b198837fe 430 PANTHER PTHR35594 30 427 2.9E-113 T 21-04-2016 SPH21_RS21070 82a9f47875c83491613b326a1080270e 186 PANTHER PTHR30042:SF2 1 185 5.4E-69 T 21-04-2016 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SPH21_RS21070 82a9f47875c83491613b326a1080270e 186 Hamap MF_00276 Potassium-transporting ATPase KdpC subunit [kdpC]. 2 185 28.384 T 21-04-2016 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SPH21_RS21070 82a9f47875c83491613b326a1080270e 186 PANTHER PTHR30042 1 185 5.4E-69 T 21-04-2016 SPH21_RS21070 82a9f47875c83491613b326a1080270e 186 PIRSF PIRSF001296 1 186 1.3E-58 T 21-04-2016 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SPH21_RS21070 82a9f47875c83491613b326a1080270e 186 TIGRFAM TIGR00681 kdpC: K+-transporting ATPase, C subunit 4 184 4.5E-50 T 21-04-2016 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SPH21_RS21070 82a9f47875c83491613b326a1080270e 186 Pfam PF02669 K+-transporting ATPase, c chain 7 183 3.1E-62 T 21-04-2016 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SPH21_RS22920 c1857786b237522dad6ca58d105db395 229 SUPERFAMILY SSF53335 22 219 4.14E-11 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS22920 c1857786b237522dad6ca58d105db395 229 PANTHER PTHR39963 1 226 5.3E-27 T 21-04-2016 SPH21_RS22920 c1857786b237522dad6ca58d105db395 229 Gene3D G3DSA:3.40.50.150 5 225 2.7E-55 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS22920 c1857786b237522dad6ca58d105db395 229 Pfam PF05430 S-adenosyl-L-methionine-dependent methyltransferase 131 223 5.8E-20 T 21-04-2016 IPR008471 MnmC-like methyltransferase GO:0016645|GO:0055114 SPH21_RS08125 a947b304700a3563dd2648c206988391 413 PANTHER PTHR10681 50 386 1.0E-13 T 21-04-2016 SPH21_RS08125 a947b304700a3563dd2648c206988391 413 PANTHER PTHR10681:SF125 50 386 1.0E-13 T 21-04-2016 SPH21_RS08125 a947b304700a3563dd2648c206988391 413 Gene3D G3DSA:3.40.30.10 2 28 1.9E-35 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS08125 a947b304700a3563dd2648c206988391 413 Gene3D G3DSA:3.40.30.10 247 413 1.9E-35 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS08125 a947b304700a3563dd2648c206988391 413 SUPERFAMILY SSF52833 247 412 2.25E-23 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS08125 a947b304700a3563dd2648c206988391 413 Pfam PF08534 Redoxin 256 387 4.3E-14 T 21-04-2016 IPR013740 Redoxin GO:0016491 SPH21_RS10465 755bced8d695f55f0fc6c4d866d3b6e5 79 Pfam PF04366 Las17-binding protein actin regulator 7 76 1.2E-11 T 21-04-2016 IPR007461 Ysc84 actin-binding domain SPH21_RS18375 d7787018e468045edcdf9fd1d60b4d5c 333 PANTHER PTHR12879 7 333 2.0E-130 T 21-04-2016 SPH21_RS18375 d7787018e468045edcdf9fd1d60b4d5c 333 PANTHER PTHR12879:SF8 7 333 2.0E-130 T 21-04-2016 SPH21_RS18375 d7787018e468045edcdf9fd1d60b4d5c 333 Pfam PF00487 Fatty acid desaturase 62 287 5.0E-30 T 21-04-2016 IPR005804 Fatty acid desaturase domain GO:0006629 SPH21_RS18375 d7787018e468045edcdf9fd1d60b4d5c 333 Pfam PF08557 Sphingolipid Delta4-desaturase (DES) 4 38 4.2E-11 T 21-04-2016 IPR013866 Sphingolipid delta4-desaturase, N-terminal MetaCyc: PWY-5129|Reactome: REACT_22258 SPH21_RS18375 d7787018e468045edcdf9fd1d60b4d5c 333 SMART SM01269 2 40 1.2E-7 T 21-04-2016 IPR013866 Sphingolipid delta4-desaturase, N-terminal MetaCyc: PWY-5129|Reactome: REACT_22258 SPH21_RS17500 7e34da072929df06d59a73e39d20a52f 245 SUPERFAMILY SSF69593 13 242 5.62E-38 T 21-04-2016 SPH21_RS17500 7e34da072929df06d59a73e39d20a52f 245 Pfam PF01553 Acyltransferase 63 188 2.1E-18 T 21-04-2016 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SPH21_RS17500 7e34da072929df06d59a73e39d20a52f 245 SMART SM00563 76 191 6.6E-20 T 21-04-2016 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SPH21_RS17500 7e34da072929df06d59a73e39d20a52f 245 Gene3D G3DSA:3.40.1130.10 65 225 8.0E-20 T 21-04-2016 SPH21_RS17500 7e34da072929df06d59a73e39d20a52f 245 PANTHER PTHR10434 9 241 8.5E-45 T 21-04-2016 SPH21_RS08215 24680a0e8402eaf26770a63ff0a36482 554 SUPERFAMILY SSF48452 17 444 2.78E-101 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08215 24680a0e8402eaf26770a63ff0a36482 554 SUPERFAMILY SSF48452 475 554 2.78E-101 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08215 24680a0e8402eaf26770a63ff0a36482 554 Pfam PF07980 SusD family 320 554 9.5E-35 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS08215 24680a0e8402eaf26770a63ff0a36482 554 Gene3D G3DSA:1.25.40.10 215 336 2.6E-34 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08215 24680a0e8402eaf26770a63ff0a36482 554 Gene3D G3DSA:1.25.40.10 380 492 2.6E-34 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08215 24680a0e8402eaf26770a63ff0a36482 554 Pfam PF14322 Starch-binding associating with outer membrane 107 235 9.4E-14 T 21-04-2016 SPH21_RS18070 8c63c537387fe5eadc0bfbd844a1bbf7 296 Pfam PF09697 Protein of unknown function (Porph_ging) 157 185 8.5E-7 T 21-04-2016 IPR005901 GLPGLI family protein SPH21_RS18070 8c63c537387fe5eadc0bfbd844a1bbf7 296 TIGRFAM TIGR01200 GLPGLI: GLPGLI family protein 11 231 2.2E-51 T 21-04-2016 IPR005901 GLPGLI family protein SPH21_RS15980 2ebc698bc528f884bfb4b6cb977cdbd9 255 Gene3D G3DSA:2.60.40.1120 49 104 3.4E-5 T 21-04-2016 IPR014766 Carboxypeptidase, regulatory domain SPH21_RS15980 2ebc698bc528f884bfb4b6cb977cdbd9 255 SUPERFAMILY SSF49464 47 107 2.75E-7 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS00655 498daf988cd2862917f175c4664f7cd7 149 Gene3D G3DSA:3.10.450.50 22 139 1.6E-32 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS00655 498daf988cd2862917f175c4664f7cd7 149 Pfam PF14534 Domain of unknown function (DUF4440) 31 133 2.8E-13 T 21-04-2016 IPR027843 Domain of unknown function DUF4440 SPH21_RS00655 498daf988cd2862917f175c4664f7cd7 149 SUPERFAMILY SSF54427 22 139 9.4E-25 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS25940 81a75376be1c0bf8550f59e81df120cc 223 PANTHER PTHR33778 1 207 9.0E-61 T 21-04-2016 SPH21_RS25940 81a75376be1c0bf8550f59e81df120cc 223 PRINTS PR01837 MgtC/SapB protein signature 67 89 2.9E-42 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS25940 81a75376be1c0bf8550f59e81df120cc 223 PRINTS PR01837 MgtC/SapB protein signature 14 33 2.9E-42 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS25940 81a75376be1c0bf8550f59e81df120cc 223 PRINTS PR01837 MgtC/SapB protein signature 95 119 2.9E-42 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS25940 81a75376be1c0bf8550f59e81df120cc 223 PRINTS PR01837 MgtC/SapB protein signature 33 51 2.9E-42 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS25940 81a75376be1c0bf8550f59e81df120cc 223 Pfam PF02308 MgtC family 11 141 7.2E-39 T 21-04-2016 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SPH21_RS04670 6b5ad09906659c63284e769c1f366426 125 Gene3D G3DSA:1.10.10.60 7 46 3.0E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14600 091fb52790aeed990fc786bdebb093de 268 SUPERFAMILY SSF56935 25 227 5.13E-9 T 21-04-2016 SPH21_RS09445 c3bdf426ec43df96be03ceff7809f91c 613 Pfam PF13722 5TM C-terminal transporter carbon starvation CstA 428 550 4.9E-33 T 21-04-2016 IPR025299 CstA, C-terminal domain SPH21_RS09445 c3bdf426ec43df96be03ceff7809f91c 613 PANTHER PTHR30252:SF3 7 568 8.8E-265 T 21-04-2016 SPH21_RS09445 c3bdf426ec43df96be03ceff7809f91c 613 Pfam PF02554 Carbon starvation protein CstA 7 372 2.0E-143 T 21-04-2016 IPR003706 CstA, N-terminal domain GO:0009267|GO:0016020 SPH21_RS09445 c3bdf426ec43df96be03ceff7809f91c 613 PANTHER PTHR30252 7 568 8.8E-265 T 21-04-2016 SPH21_RS16705 ca96c9432b454eb2f40594d0d89d81bb 335 SUPERFAMILY SSF56954 3 170 2.88E-6 T 21-04-2016 SPH21_RS16705 ca96c9432b454eb2f40594d0d89d81bb 335 PANTHER PTHR30097:SF4 188 329 2.6E-30 T 21-04-2016 SPH21_RS16705 ca96c9432b454eb2f40594d0d89d81bb 335 Gene3D G3DSA:1.20.1600.10 95 169 4.5E-4 T 21-04-2016 SPH21_RS16705 ca96c9432b454eb2f40594d0d89d81bb 335 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion 186 255 2.0E-16 T 21-04-2016 IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain SPH21_RS16705 ca96c9432b454eb2f40594d0d89d81bb 335 PANTHER PTHR30097 188 329 2.6E-30 T 21-04-2016 SPH21_RS02510 c5822b4cdd5acf0d40fbfc7d8b963685 267 Pfam PF14321 Domain of unknown function (DUF4382) 34 174 1.6E-27 T 21-04-2016 IPR025491 Domain of unknown function DUF4382 SPH21_RS23350 004b55ab4fab66f281211c6be917f088 275 SUPERFAMILY SSF53850 20 272 3.71E-45 T 21-04-2016 SPH21_RS23350 004b55ab4fab66f281211c6be917f088 275 PANTHER PTHR30570:SF1 17 271 1.4E-37 T 21-04-2016 SPH21_RS23350 004b55ab4fab66f281211c6be917f088 275 PANTHER PTHR30570 17 271 1.4E-37 T 21-04-2016 SPH21_RS23350 004b55ab4fab66f281211c6be917f088 275 Pfam PF12849 PBP superfamily domain 18 256 8.9E-27 T 21-04-2016 IPR024370 PBP domain SPH21_RS23350 004b55ab4fab66f281211c6be917f088 275 Gene3D G3DSA:3.40.190.10 20 155 2.6E-30 T 21-04-2016 SPH21_RS03860 f711feefbce9820becf90c9ad411df19 274 PANTHER PTHR13754 1 257 1.4E-58 T 21-04-2016 SPH21_RS03860 f711feefbce9820becf90c9ad411df19 274 SMART SM00849 13 203 7.1E-8 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS03860 f711feefbce9820becf90c9ad411df19 274 Pfam PF12706 Beta-lactamase superfamily domain 26 201 8.9E-19 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS03860 f711feefbce9820becf90c9ad411df19 274 SUPERFAMILY SSF56281 1 232 3.56E-38 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS03860 f711feefbce9820becf90c9ad411df19 274 PANTHER PTHR13754:SF15 1 257 1.4E-58 T 21-04-2016 SPH21_RS03860 f711feefbce9820becf90c9ad411df19 274 Gene3D G3DSA:3.60.15.10 11 234 6.3E-30 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS07605 14038f2150aa7e466fd8081e383bb6b9 148 Pfam PF02367 Threonylcarbamoyl adenosine biosynthesis protein TsaE 9 132 3.3E-34 T 21-04-2016 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 SPH21_RS07605 14038f2150aa7e466fd8081e383bb6b9 148 PANTHER PTHR33540 1 135 5.5E-32 T 21-04-2016 SPH21_RS07605 14038f2150aa7e466fd8081e383bb6b9 148 TIGRFAM TIGR00150 T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE 7 135 1.7E-30 T 21-04-2016 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 SPH21_RS07605 14038f2150aa7e466fd8081e383bb6b9 148 Gene3D G3DSA:3.40.50.300 3 137 2.0E-39 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS07605 14038f2150aa7e466fd8081e383bb6b9 148 SUPERFAMILY SSF52540 20 117 2.59E-18 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS06725 b615355eba30c4e669e5beea88cca75a 678 Pfam PF00912 Transglycosylase 431 585 5.1E-46 T 21-04-2016 IPR001264 Glycosyl transferase, family 51 UniPathway: UPA00219 SPH21_RS06725 b615355eba30c4e669e5beea88cca75a 678 PANTHER PTHR30400:SF0 13 655 2.9E-84 T 21-04-2016 SPH21_RS06725 b615355eba30c4e669e5beea88cca75a 678 PANTHER PTHR30400 13 655 2.9E-84 T 21-04-2016 SPH21_RS06725 b615355eba30c4e669e5beea88cca75a 678 SUPERFAMILY SSF53955 420 585 1.1E-46 T 21-04-2016 IPR023346 Lysozyme-like domain SPH21_RS06725 b615355eba30c4e669e5beea88cca75a 678 Gene3D G3DSA:1.10.3810.10 437 585 1.2E-48 T 21-04-2016 SPH21_RS07685 541fd0c5f73475125b26770b8cb14faa 407 PANTHER PTHR34856 1 407 3.5E-71 T 21-04-2016 SPH21_RS07685 541fd0c5f73475125b26770b8cb14faa 407 PANTHER PTHR34856:SF4 1 407 3.5E-71 T 21-04-2016 SPH21_RS06205 7033eb4f160ca301c094412d4b59d9f5 506 SUPERFAMILY SSF48452 16 506 1.14E-107 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06205 7033eb4f160ca301c094412d4b59d9f5 506 Pfam PF07980 SusD family 347 506 7.4E-40 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS06205 7033eb4f160ca301c094412d4b59d9f5 506 Gene3D G3DSA:1.25.40.10 208 307 9.0E-34 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06205 7033eb4f160ca301c094412d4b59d9f5 506 Gene3D G3DSA:1.25.40.10 345 441 9.0E-34 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS06205 7033eb4f160ca301c094412d4b59d9f5 506 Pfam PF14322 Starch-binding associating with outer membrane 20 225 2.6E-27 T 21-04-2016 SPH21_RS20790 a5846d98baebf2f6b2c9dc15a298e6b1 264 Gene3D G3DSA:3.30.70.900 150 263 6.6E-7 T 21-04-2016 SPH21_RS20790 a5846d98baebf2f6b2c9dc15a298e6b1 264 SUPERFAMILY SSF54909 34 145 6.97E-10 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS20790 a5846d98baebf2f6b2c9dc15a298e6b1 264 SUPERFAMILY SSF54909 150 263 5.54E-14 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS20790 a5846d98baebf2f6b2c9dc15a298e6b1 264 Pfam PF07978 NIPSNAP 158 263 9.6E-11 T 21-04-2016 IPR012577 NIPSNAP SPH21_RS20790 a5846d98baebf2f6b2c9dc15a298e6b1 264 Pfam PF07978 NIPSNAP 38 112 4.1E-7 T 21-04-2016 IPR012577 NIPSNAP SPH21_RS16400 5b6bd302c897077ed559cb824cd48382 211 Gene3D G3DSA:2.60.40.1190 45 210 1.9E-10 T 21-04-2016 IPR010502 Carbohydrate-binding domain, family 9 GO:0004553|GO:0016052|GO:0030246 MetaCyc: PWY-6784 SPH21_RS16400 5b6bd302c897077ed559cb824cd48382 211 Pfam PF16011 Carbohydrate-binding family 9 20 209 2.4E-79 T 21-04-2016 IPR010502 Carbohydrate-binding domain, family 9 GO:0004553|GO:0016052|GO:0030246 MetaCyc: PWY-6784 SPH21_RS16400 5b6bd302c897077ed559cb824cd48382 211 SUPERFAMILY SSF49344 45 209 2.24E-12 T 21-04-2016 SPH21_RS00090 6887a79aabaa1670fb6db7a26c3b371c 282 Pfam PF10670 Domain of unknown function (DUF4198) 35 260 8.9E-21 T 21-04-2016 IPR019613 Protein of unknown function DUF4198 SPH21_RS23385 8bda7b3e8aa7065d183474e41ce834bc 344 SUPERFAMILY SSF69917 79 217 4.97E-7 T 21-04-2016 IPR020080 Outer membrane adhesin/peptidase omptin GO:0004190 SPH21_RS12370 b742523ef3fc493029d0182210476e03 370 SUPERFAMILY SSF56300 36 224 1.07E-14 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS12370 b742523ef3fc493029d0182210476e03 370 SUPERFAMILY SSF56300 267 341 1.07E-14 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS12370 b742523ef3fc493029d0182210476e03 370 Gene3D G3DSA:3.60.21.10 34 285 4.2E-13 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS12370 b742523ef3fc493029d0182210476e03 370 Pfam PF00149 Calcineurin-like phosphoesterase 61 285 4.1E-8 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS03695 521f3a0df381ca87676962e0ec8003fd 167 Pfam PF04390 Lipopolysaccharide-assembly 14 162 2.1E-17 T 21-04-2016 IPR007485 LPS-assembly lipoprotein LptE GO:0019867|GO:0043165 SPH21_RS00115 ab8f638ee66df715f47d8b53d3c8cda2 288 SMART SM00558 80 251 0.0029 T 21-04-2016 IPR003347 JmjC domain SPH21_RS00115 ab8f638ee66df715f47d8b53d3c8cda2 288 SUPERFAMILY SSF51197 6 254 3.16E-44 T 21-04-2016 SPH21_RS00115 ab8f638ee66df715f47d8b53d3c8cda2 288 PANTHER PTHR12461 7 233 1.0E-35 T 21-04-2016 SPH21_RS00115 ab8f638ee66df715f47d8b53d3c8cda2 288 Gene3D G3DSA:2.60.120.650 8 233 4.9E-33 T 21-04-2016 SPH21_RS00115 ab8f638ee66df715f47d8b53d3c8cda2 288 Pfam PF13621 Cupin-like domain 15 233 5.6E-26 T 21-04-2016 SPH21_RS15005 be059b8b98e0b6d12791e158dc55ea78 119 PANTHER PTHR34703:SF1 2 114 4.2E-32 T 21-04-2016 SPH21_RS15005 be059b8b98e0b6d12791e158dc55ea78 119 Pfam PF03334 Na+/H+ antiporter subunit 12 90 2.1E-24 T 21-04-2016 IPR005133 Na+/H+ antiporter subunit G GO:0005451|GO:0015672|GO:0015992 SPH21_RS15005 be059b8b98e0b6d12791e158dc55ea78 119 TIGRFAM TIGR01300 CPA3_mnhG_phaG: monovalent cation/proton antiporter, MnhG/PhaG subunit 13 96 3.4E-22 T 21-04-2016 IPR005133 Na+/H+ antiporter subunit G GO:0005451|GO:0015672|GO:0015992 SPH21_RS15005 be059b8b98e0b6d12791e158dc55ea78 119 PANTHER PTHR34703 2 114 4.2E-32 T 21-04-2016 SPH21_RS02795 5380e776320ab9375730dabd6cca361f 1455 Pfam PF04357 TamB, inner membrane protein subunit of TAM complex 994 1412 1.0E-46 T 21-04-2016 IPR007452 Translocation and assembly module TamB SPH21_RS12025 dd0ab5f0004d4aa9a4e1dd71851c4436 257 SUPERFAMILY SSF56112 28 178 4.59E-6 T 21-04-2016 IPR011009 Protein kinase-like domain SPH21_RS12025 dd0ab5f0004d4aa9a4e1dd71851c4436 257 Pfam PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family 59 184 3.9E-9 T 21-04-2016 IPR010440 Lipopolysaccharide kinase GO:0005524|GO:0016020|GO:0016773 SPH21_RS11095 27e13926709a1037ecf6592ecc755286 158 SUPERFAMILY SSF56925 34 157 7.85E-6 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS13425 87ed95a70f4e1edf3b3546f795b91946 160 Pfam PF04448 Protein of unknown function (DUF551) 96 158 1.5E-5 T 21-04-2016 IPR007539 Domain of unknown function DUF551 SPH21_RS23750 68edfde6a65a1950f7015d39420964a6 366 SUPERFAMILY SSF140931 100 289 7.59E-38 T 21-04-2016 IPR003812 Fido domain SPH21_RS23750 68edfde6a65a1950f7015d39420964a6 366 PANTHER PTHR13504 2 363 1.1E-72 T 21-04-2016 SPH21_RS23750 68edfde6a65a1950f7015d39420964a6 366 Pfam PF02661 Fic/DOC family 113 224 6.4E-23 T 21-04-2016 IPR003812 Fido domain SPH21_RS23750 68edfde6a65a1950f7015d39420964a6 366 PANTHER PTHR13504:SF33 2 363 1.1E-72 T 21-04-2016 SPH21_RS23750 68edfde6a65a1950f7015d39420964a6 366 Gene3D G3DSA:1.10.3290.10 31 293 3.6E-62 T 21-04-2016 IPR003812 Fido domain SPH21_RS23750 68edfde6a65a1950f7015d39420964a6 366 Pfam PF13776 Domain of unknown function (DUF4172) 3 84 1.8E-24 T 21-04-2016 IPR025230 Domain of unknown function DUF4172 SPH21_RS03740 98ebf4d43d01311fad83791381f94243 260 Pfam PF00378 Enoyl-CoA hydratase/isomerase 10 258 6.0E-65 T 21-04-2016 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SPH21_RS03740 98ebf4d43d01311fad83791381f94243 260 PANTHER PTHR11941:SF54 1 257 1.9E-93 T 21-04-2016 SPH21_RS03740 98ebf4d43d01311fad83791381f94243 260 Gene3D G3DSA:3.90.226.10 1 257 5.7E-89 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS03740 98ebf4d43d01311fad83791381f94243 260 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 102 122 - T 21-04-2016 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SPH21_RS03740 98ebf4d43d01311fad83791381f94243 260 PANTHER PTHR11941 1 257 1.9E-93 T 21-04-2016 SPH21_RS03740 98ebf4d43d01311fad83791381f94243 260 SUPERFAMILY SSF52096 1 258 1.48E-86 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS12465 fc2afde6f89a18485e1c98514218bcf0 319 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 42 234 2.8E-12 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS12465 fc2afde6f89a18485e1c98514218bcf0 319 SUPERFAMILY SSF52266 37 244 2.44E-25 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS12465 fc2afde6f89a18485e1c98514218bcf0 319 PANTHER PTHR30383 98 313 1.3E-13 T 21-04-2016 SPH21_RS12465 fc2afde6f89a18485e1c98514218bcf0 319 PANTHER PTHR30383 15 82 1.3E-13 T 21-04-2016 SPH21_RS12465 fc2afde6f89a18485e1c98514218bcf0 319 Gene3D G3DSA:3.40.50.1110 38 244 1.4E-27 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS24780 eec616b70056324d3194b4e37c21dd1d 195 Pfam PF12704 MacB-like periplasmic core domain 45 195 5.0E-11 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS24780 eec616b70056324d3194b4e37c21dd1d 195 PANTHER PTHR30489 20 191 5.1E-19 T 21-04-2016 SPH21_RS24780 eec616b70056324d3194b4e37c21dd1d 195 PANTHER PTHR30489:SF14 20 191 5.1E-19 T 21-04-2016 SPH21_RS10495 ee70a068946416a869aea2e3bf0b29b5 215 Gene3D G3DSA:3.40.1050.10 3 206 1.6E-53 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS10495 ee70a068946416a869aea2e3bf0b29b5 215 PANTHER PTHR11002:SF22 4 206 5.4E-64 T 21-04-2016 SPH21_RS10495 ee70a068946416a869aea2e3bf0b29b5 215 SUPERFAMILY SSF53056 3 206 7.06E-55 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS10495 ee70a068946416a869aea2e3bf0b29b5 215 SMART SM00947 46 207 2.1E-50 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS10495 ee70a068946416a869aea2e3bf0b29b5 215 Pfam PF00484 Carbonic anhydrase 53 202 1.5E-37 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS10495 ee70a068946416a869aea2e3bf0b29b5 215 PANTHER PTHR11002 4 206 5.4E-64 T 21-04-2016 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SPH21_RS13665 528c34b4b0a21f9a45f9f357e4db101e 509 Gene3D G3DSA:1.25.40.10 365 456 8.3E-15 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13665 528c34b4b0a21f9a45f9f357e4db101e 509 Gene3D G3DSA:1.25.40.10 233 332 8.3E-15 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS13665 528c34b4b0a21f9a45f9f357e4db101e 509 Pfam PF07980 SusD family 368 508 3.1E-21 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS13665 528c34b4b0a21f9a45f9f357e4db101e 509 Pfam PF14322 Starch-binding associating with outer membrane 48 177 2.2E-9 T 21-04-2016 SPH21_RS13665 528c34b4b0a21f9a45f9f357e4db101e 509 SUPERFAMILY SSF48452 23 508 3.92E-76 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21345 bb97a8b791df2a151cd0227f1cd0c3c4 126 PANTHER PTHR34187 11 122 1.1E-16 T 21-04-2016 SPH21_RS21345 bb97a8b791df2a151cd0227f1cd0c3c4 126 Pfam PF02656 Domain of unknown function (DUF202) 11 89 1.2E-19 T 21-04-2016 IPR003807 Domain of unknown function DUF202 SPH21_RS06915 c460acb2e6f81ab0a6e94ffa002d59d7 257 Gene3D G3DSA:1.20.950.10 175 226 6.3E-10 T 21-04-2016 SPH21_RS06915 c460acb2e6f81ab0a6e94ffa002d59d7 257 Gene3D G3DSA:1.20.950.10 17 130 6.3E-10 T 21-04-2016 SPH21_RS06915 c460acb2e6f81ab0a6e94ffa002d59d7 257 SUPERFAMILY SSF81343 6 139 3.27E-40 T 21-04-2016 SPH21_RS06915 c460acb2e6f81ab0a6e94ffa002d59d7 257 SUPERFAMILY SSF81343 184 255 3.27E-40 T 21-04-2016 SPH21_RS06915 c460acb2e6f81ab0a6e94ffa002d59d7 257 TIGRFAM TIGR02046 sdhC_b558_fam: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family 10 255 5.6E-45 T 21-04-2016 IPR011138 Succinate dehydrogenase cytochrome b558 subunit UniPathway: UPA00223 SPH21_RS06395 7fbfae6c1291737f73a1ca1eafac54ae 568 Pfam PF13205 Bacterial Ig-like domain 50 149 7.1E-12 T 21-04-2016 IPR032812 SbsA, Ig-like domain SPH21_RS02430 0e7b624611c1508dee26408cc86ca8e9 559 Pfam PF14322 Starch-binding associating with outer membrane 92 225 2.0E-18 T 21-04-2016 SPH21_RS02430 0e7b624611c1508dee26408cc86ca8e9 559 SUPERFAMILY SSF48452 17 559 2.37E-110 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02430 0e7b624611c1508dee26408cc86ca8e9 559 Gene3D G3DSA:1.25.40.10 205 329 4.0E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02430 0e7b624611c1508dee26408cc86ca8e9 559 Gene3D G3DSA:1.25.40.10 405 497 4.0E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02430 0e7b624611c1508dee26408cc86ca8e9 559 Pfam PF07980 SusD family 273 559 1.2E-38 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS15105 a9c541ef85ab0c0b46c3922d282bf42e 180 Pfam PF13618 Gluconate 2-dehydrogenase subunit 3 42 164 1.4E-21 T 21-04-2016 IPR027056 Gluconate 2-dehydrogenase subunit 3 KEGG: 00030+1.1.99.3|MetaCyc: PWY-7165 SPH21_RS09350 fc22132b67c996e63f87d5abfe95689f 60 TIGRFAM TIGR03949 bact_IIb_cerein: class IIb bacteriocin, lactobin A/cerein 7B family 15 52 2.2E-5 T 21-04-2016 IPR023991 Bacteriocin, class IIb, lactobin A/cerein 7B family SPH21_RS13340 87af778a71b99b409c4963d86f8f0cfe 346 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 11 319 1.5E-30 T 21-04-2016 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SPH21_RS07990 88f0680b9ac1b34a0e3b44693a863cfe 604 Gene3D G3DSA:3.40.710.10 214 597 1.2E-77 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS07990 88f0680b9ac1b34a0e3b44693a863cfe 604 PANTHER PTHR22935:SF10 228 598 4.9E-69 T 21-04-2016 SPH21_RS07990 88f0680b9ac1b34a0e3b44693a863cfe 604 SUPERFAMILY SSF56601 224 596 1.88E-68 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS07990 88f0680b9ac1b34a0e3b44693a863cfe 604 PANTHER PTHR22935 228 598 4.9E-69 T 21-04-2016 SPH21_RS07990 88f0680b9ac1b34a0e3b44693a863cfe 604 Pfam PF00144 Beta-lactamase 230 577 3.3E-49 T 21-04-2016 IPR001466 Beta-lactamase-related SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 SUPERFAMILY SSF51126 51 436 1.11E-79 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 PANTHER PTHR31339 55 167 2.9E-116 T 21-04-2016 SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 PANTHER PTHR31339 195 435 2.9E-116 T 21-04-2016 SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 SMART SM00710 264 285 8.7 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 SMART SM00710 239 263 1800.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 SMART SM00710 298 338 790.0 T 21-04-2016 IPR006626 Parallel beta-helix repeat SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 PANTHER PTHR31339:SF0 55 167 2.9E-116 T 21-04-2016 SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 PANTHER PTHR31339:SF0 195 435 2.9E-116 T 21-04-2016 SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 Pfam PF00295 Glycosyl hydrolases family 28 203 438 4.9E-27 T 21-04-2016 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SPH21_RS02450 3b1b3fda3b201caebb787891557e6f40 455 Gene3D G3DSA:2.160.20.10 54 438 8.9E-96 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 PANTHER PTHR10342:SF199 376 559 5.9E-171 T 21-04-2016 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 PANTHER PTHR10342:SF199 11 266 5.9E-171 T 21-04-2016 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 PANTHER PTHR10342:SF199 291 345 5.9E-171 T 21-04-2016 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 SUPERFAMILY SSF53649 37 538 3.53E-145 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 PANTHER PTHR10342 376 559 5.9E-171 T 21-04-2016 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 PANTHER PTHR10342 11 266 5.9E-171 T 21-04-2016 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 PANTHER PTHR10342 291 345 5.9E-171 T 21-04-2016 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 Gene3D G3DSA:3.40.720.10 35 460 2.3E-129 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 Pfam PF00884 Sulfatase 38 427 1.8E-80 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS04110 5cc7dd2958c14c691649e0e893cff41b 559 Gene3D G3DSA:3.30.1120.10 465 543 1.5E-20 T 21-04-2016 SPH21_RS08870 d93a6053e3b81d77e8f1e846224b6788 571 Pfam PF14052 Capsule assembly protein Wzi 107 492 1.6E-10 T 21-04-2016 IPR026950 Capsule assembly protein Wzi SPH21_RS08850 0f15a264721f7ac6baed6f29713dab68 268 SUPERFAMILY SSF53448 7 204 1.59E-56 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08850 0f15a264721f7ac6baed6f29713dab68 268 PANTHER PTHR22916 7 268 7.2E-55 T 21-04-2016 SPH21_RS08850 0f15a264721f7ac6baed6f29713dab68 268 Gene3D G3DSA:3.90.550.10 7 210 1.9E-53 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08850 0f15a264721f7ac6baed6f29713dab68 268 Pfam PF00535 Glycosyl transferase family 2 8 137 1.1E-34 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS23530 3a91a1f30af4406e0bd11c101cac8981 506 Pfam PF03321 GH3 auxin-responsive promoter 190 493 4.4E-49 T 21-04-2016 IPR004993 GH3 family KEGG: 00220+6.3.2.-|KEGG: 00261+6.3.2.-|KEGG: 00380+6.3.2.- SPH21_RS23530 3a91a1f30af4406e0bd11c101cac8981 506 PANTHER PTHR31901:SF5 23 498 3.8E-23 T 21-04-2016 SPH21_RS23530 3a91a1f30af4406e0bd11c101cac8981 506 PANTHER PTHR31901 23 498 3.8E-23 T 21-04-2016 IPR004993 GH3 family KEGG: 00220+6.3.2.-|KEGG: 00261+6.3.2.-|KEGG: 00380+6.3.2.- SPH21_RS14185 3daad2688f7d0d478fa517df59f45621 385 Gene3D G3DSA:3.20.20.70 45 363 8.2E-46 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS14185 3daad2688f7d0d478fa517df59f45621 385 Pfam PF00701 Dihydrodipicolinate synthetase family 45 245 2.9E-6 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS14185 3daad2688f7d0d478fa517df59f45621 385 SUPERFAMILY SSF51569 45 362 5.97E-29 T 21-04-2016 SPH21_RS14185 3daad2688f7d0d478fa517df59f45621 385 SMART SM01130 41 364 1.2E-7 T 21-04-2016 IPR002220 DapA-like GO:0008152|GO:0016829 SPH21_RS21900 f707774aeea66487e4ee48f7f9d8b499 167 Pfam PF13924 Lipocalin-like domain 32 166 2.4E-29 T 21-04-2016 IPR024311 Lipocalin-like domain SPH21_RS25900 b4c381dcbea5f0befcb88b1c5dde061d 251 Gene3D G3DSA:2.50.20.10 149 223 6.5E-4 T 21-04-2016 SPH21_RS09605 fd0198fbf1dc19395da71349e07aa6f0 379 Pfam PF04230 Polysaccharide pyruvyl transferase 18 304 2.1E-14 T 21-04-2016 IPR007345 Polysaccharide pyruvyl transferase SPH21_RS02245 6b4812d9df94fec49369b278f618796b 404 Gene3D G3DSA:2.60.120.10 10 266 9.2E-33 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS02245 6b4812d9df94fec49369b278f618796b 404 SUPERFAMILY SSF51182 11 349 6.48E-48 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS21995 fe23551b2b0ceaadc2cd3add294aecc0 137 SUPERFAMILY SSF54593 1 123 1.03E-19 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS21995 fe23551b2b0ceaadc2cd3add294aecc0 137 Gene3D G3DSA:3.10.180.10 1 123 4.2E-27 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS21995 fe23551b2b0ceaadc2cd3add294aecc0 137 Pfam PF12681 Glyoxalase-like domain 8 124 1.1E-7 T 21-04-2016 IPR025870 Glyoxalase-like domain SPH21_RS07205 6f3d75148466e41ec5de7558fc3cfa64 129 Gene3D G3DSA:2.102.10.10 34 127 7.8E-9 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS07205 6f3d75148466e41ec5de7558fc3cfa64 129 SUPERFAMILY SSF50022 42 127 5.09E-8 T 21-04-2016 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SPH21_RS05335 afdb1e7e61d2c1ad319244f602b44d4a 216 Pfam PF02390 Putative methyltransferase 39 208 3.9E-32 T 21-04-2016 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 UniPathway: UPA00989 SPH21_RS05335 afdb1e7e61d2c1ad319244f602b44d4a 216 Gene3D G3DSA:3.40.50.150 32 154 9.3E-14 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05335 afdb1e7e61d2c1ad319244f602b44d4a 216 PANTHER PTHR23417 33 213 9.0E-41 T 21-04-2016 SPH21_RS05335 afdb1e7e61d2c1ad319244f602b44d4a 216 Hamap MF_01057 tRNA (guanine-N(7)-)-methyltransferase [trmB]. 7 216 22.995 T 21-04-2016 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 UniPathway: UPA00989 SPH21_RS05335 afdb1e7e61d2c1ad319244f602b44d4a 216 PANTHER PTHR23417:SF14 33 213 9.0E-41 T 21-04-2016 SPH21_RS05335 afdb1e7e61d2c1ad319244f602b44d4a 216 SUPERFAMILY SSF53335 34 212 1.81E-25 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS05335 afdb1e7e61d2c1ad319244f602b44d4a 216 TIGRFAM TIGR00091 TIGR00091: tRNA (guanine-N(7)-)-methyltransferase 30 208 4.9E-35 T 21-04-2016 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 UniPathway: UPA00989 SPH21_RS25685 fe93129e956614e3e0cc65b65e4954b5 685 PANTHER PTHR23422:SF12 9 674 3.5E-211 T 21-04-2016 SPH21_RS25685 fe93129e956614e3e0cc65b65e4954b5 685 PANTHER PTHR23422 9 674 3.5E-211 T 21-04-2016 SPH21_RS25685 fe93129e956614e3e0cc65b65e4954b5 685 Pfam PF03571 Peptidase family M49 474 657 4.5E-9 T 21-04-2016 SPH21_RS25685 fe93129e956614e3e0cc65b65e4954b5 685 Pfam PF03571 Peptidase family M49 244 468 2.7E-33 T 21-04-2016 SPH21_RS07795 8b58e8b2d10edee705308f28cd49b3ec 359 PANTHER PTHR10859:SF99 14 254 4.0E-32 T 21-04-2016 SPH21_RS07795 8b58e8b2d10edee705308f28cd49b3ec 359 PANTHER PTHR10859 14 254 4.0E-32 T 21-04-2016 SPH21_RS07795 8b58e8b2d10edee705308f28cd49b3ec 359 SUPERFAMILY SSF53448 24 297 5.56E-45 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS07795 8b58e8b2d10edee705308f28cd49b3ec 359 Gene3D G3DSA:3.90.550.10 27 259 3.8E-36 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS07795 8b58e8b2d10edee705308f28cd49b3ec 359 Pfam PF00535 Glycosyl transferase family 2 28 197 6.1E-26 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS12970 3b111f5dea7a9d37dbae290f5be9f921 472 PANTHER PTHR36120:SF1 3 472 3.3E-175 T 21-04-2016 SPH21_RS12970 3b111f5dea7a9d37dbae290f5be9f921 472 Pfam PF02952 L-fucose isomerase, C-terminal domain 340 466 1.6E-27 T 21-04-2016 IPR015888 L-fucose isomerase, C-terminal GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25|UniPathway: UPA00563 SPH21_RS12970 3b111f5dea7a9d37dbae290f5be9f921 472 SUPERFAMILY SSF53743 3 322 4.84E-54 T 21-04-2016 IPR009015 L-fucose isomerase, N-terminal/central domain GO:0005737|GO:0005996|GO:0016861 SPH21_RS12970 3b111f5dea7a9d37dbae290f5be9f921 472 PANTHER PTHR36120 3 472 3.3E-175 T 21-04-2016 SPH21_RS02315 cc38773ac4b5cb7d640b983a916e6df6 722 Gene3D G3DSA:1.50.10.10 376 688 1.6E-12 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS02315 cc38773ac4b5cb7d640b983a916e6df6 722 SUPERFAMILY SSF48208 313 715 1.36E-55 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS23365 851ce2efaacaac93f4aec2fad6e732df 229 Gene3D G3DSA:1.10.10.10 114 207 1.1E-10 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23365 851ce2efaacaac93f4aec2fad6e732df 229 SUPERFAMILY SSF46894 143 207 8.16E-9 T 21-04-2016 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SPH21_RS23365 851ce2efaacaac93f4aec2fad6e732df 229 SMART SM00421 148 205 0.0033 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS23365 851ce2efaacaac93f4aec2fad6e732df 229 Pfam PF00196 Bacterial regulatory proteins, luxR family 152 204 7.7E-7 T 21-04-2016 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SPH21_RS08465 45e0f3a162eda650c9877dde545d3e81 195 SUPERFAMILY SSF56925 40 171 4.32E-7 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS03730 35a342120111b6676caf1beba39280fc 89 Pfam PF12732 YtxH-like protein 9 77 1.6E-16 T 21-04-2016 IPR024623 Uncharacterised protein family YtxH SPH21_RS03635 88b19fc06e2a0f844eca7277e1fa95bc 264 Pfam PF04536 Acid phosphatase of thylakoid lumen protein 32 156 1.7E-40 T 21-04-2016 IPR007621 TPM domain SPH21_RS03635 88b19fc06e2a0f844eca7277e1fa95bc 264 PANTHER PTHR30373:SF2 14 194 1.0E-48 T 21-04-2016 SPH21_RS03635 88b19fc06e2a0f844eca7277e1fa95bc 264 PANTHER PTHR30373 14 194 1.0E-48 T 21-04-2016 SPH21_RS06950 558dbca3356da3c0373740e703495ce5 437 Gene3D G3DSA:2.40.160.60 48 396 5.8E-27 T 21-04-2016 SPH21_RS06950 558dbca3356da3c0373740e703495ce5 437 SUPERFAMILY SSF56935 45 382 9.16E-12 T 21-04-2016 SPH21_RS16345 9f230e0718e7b3defc4dcf2004f0452b 159 Gene3D G3DSA:3.40.50.20 1 106 1.9E-11 T 21-04-2016 IPR016185 Pre-ATP-grasp domain SPH21_RS10420 f65d23ee84973f59f6c37e10fe5d889d 114 Pfam PF09919 Uncharacterized conserved protein (DUF2149) 21 111 7.9E-32 T 21-04-2016 IPR018676 Protein of unknown function DUF2149 SPH21_RS08055 f0aeb82652814edd949b63fdc937d1b5 336 SUPERFAMILY SSF53448 7 301 1.34E-28 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08055 f0aeb82652814edd949b63fdc937d1b5 336 Pfam PF00535 Glycosyl transferase family 2 9 113 9.4E-13 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS08055 f0aeb82652814edd949b63fdc937d1b5 336 PANTHER PTHR22916:SF29 181 240 2.3E-16 T 21-04-2016 SPH21_RS08055 f0aeb82652814edd949b63fdc937d1b5 336 PANTHER PTHR22916:SF29 7 146 2.3E-16 T 21-04-2016 SPH21_RS08055 f0aeb82652814edd949b63fdc937d1b5 336 PANTHER PTHR22916 181 240 2.3E-16 T 21-04-2016 SPH21_RS08055 f0aeb82652814edd949b63fdc937d1b5 336 PANTHER PTHR22916 7 146 2.3E-16 T 21-04-2016 SPH21_RS08055 f0aeb82652814edd949b63fdc937d1b5 336 Gene3D G3DSA:3.90.550.10 8 264 5.5E-20 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 Gene3D G3DSA:3.40.720.10 27 190 3.5E-103 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 Gene3D G3DSA:3.40.720.10 231 438 3.5E-103 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 SUPERFAMILY SSF53649 27 504 1.74E-119 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 Pfam PF16385 Domain of unknown function 404 496 1.8E-25 T 21-04-2016 IPR032158 Domain of unknown function DUF4994 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 Gene3D G3DSA:3.30.1120.10 439 505 1.8E-16 T 21-04-2016 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 ProSitePatterns PS00523 Sulfatases signature 1. 75 87 - T 21-04-2016 IPR024607 Sulfatase, conserved site SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 Pfam PF00884 Sulfatase 29 398 3.5E-67 T 21-04-2016 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 PANTHER PTHR10342 231 327 1.0E-141 T 21-04-2016 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 PANTHER PTHR10342 344 503 1.0E-141 T 21-04-2016 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 PANTHER PTHR10342 1 186 1.0E-141 T 21-04-2016 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 PANTHER PTHR10342:SF22 231 327 1.0E-141 T 21-04-2016 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 PANTHER PTHR10342:SF22 344 503 1.0E-141 T 21-04-2016 SPH21_RS24905 909faf3bb52cedfb641d6bcdd9d2d474 506 PANTHER PTHR10342:SF22 1 186 1.0E-141 T 21-04-2016 SPH21_RS17100 53a4de847de0bfa08aa6ca33ab10b9c8 515 Pfam PF12771 Starch-binding associating with outer membrane 6 306 4.0E-28 T 21-04-2016 SPH21_RS17100 53a4de847de0bfa08aa6ca33ab10b9c8 515 Pfam PF12741 Susd and RagB outer membrane lipoprotein 409 515 2.0E-13 T 21-04-2016 IPR024302 SusD-like SPH21_RS17100 53a4de847de0bfa08aa6ca33ab10b9c8 515 SUPERFAMILY SSF48452 22 515 6.95E-109 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS17100 53a4de847de0bfa08aa6ca33ab10b9c8 515 PANTHER PTHR35148 3 514 3.9E-38 T 21-04-2016 SPH21_RS16680 e5f96be09cd33e2a64851fd286d0c674 209 Pfam PF04326 Putative DNA-binding domain 11 123 2.0E-22 T 21-04-2016 IPR007421 Schlafen, AAA domain GO:0005524 SPH21_RS16680 e5f96be09cd33e2a64851fd286d0c674 209 Gene3D G3DSA:1.10.10.10 148 199 1.4E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS14640 25ff4ae2207e17ac393617c025b2c31a 435 Pfam PF11700 Vacuole effluxer Atg22 like 5 428 3.7E-68 T 21-04-2016 IPR024671 Autophagy-related protein 22-like SPH21_RS14640 25ff4ae2207e17ac393617c025b2c31a 435 SUPERFAMILY SSF103473 9 429 1.31E-28 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS14640 25ff4ae2207e17ac393617c025b2c31a 435 PANTHER PTHR23519 9 427 2.3E-52 T 21-04-2016 SPH21_RS14640 25ff4ae2207e17ac393617c025b2c31a 435 Gene3D G3DSA:1.20.1250.20 56 201 2.2E-7 T 21-04-2016 SPH21_RS14640 25ff4ae2207e17ac393617c025b2c31a 435 Gene3D G3DSA:1.20.1250.20 250 430 9.7E-15 T 21-04-2016 SPH21_RS21905 16d6d732397a343d660683ccbbf4e93b 298 SUPERFAMILY SSF51735 2 248 3.27E-57 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21905 16d6d732397a343d660683ccbbf4e93b 298 PANTHER PTHR14194 2 296 1.3E-69 T 21-04-2016 SPH21_RS21905 16d6d732397a343d660683ccbbf4e93b 298 Gene3D G3DSA:3.40.50.720 2 223 2.8E-49 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS21905 16d6d732397a343d660683ccbbf4e93b 298 Pfam PF05368 NmrA-like family 4 229 1.5E-36 T 21-04-2016 IPR008030 NmrA-like domain SPH21_RS20885 7cf0b1e633098a3162d37495efd6b44c 177 Gene3D G3DSA:3.40.430.10 2 176 2.9E-37 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS20885 7cf0b1e633098a3162d37495efd6b44c 177 PANTHER PTHR38011 2 177 7.8E-20 T 21-04-2016 SPH21_RS20885 7cf0b1e633098a3162d37495efd6b44c 177 SUPERFAMILY SSF53597 2 176 3.14E-38 T 21-04-2016 IPR024072 Dihydrofolate reductase-like domain SPH21_RS20885 7cf0b1e633098a3162d37495efd6b44c 177 Pfam PF01872 RibD C-terminal domain 2 168 8.4E-21 T 21-04-2016 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SPH21_RS14505 30c54e1b39ad3107526b6bad498c7d97 296 PANTHER PTHR33281 12 281 3.3E-40 T 21-04-2016 SPH21_RS14505 30c54e1b39ad3107526b6bad498c7d97 296 Pfam PF01062 Bestrophin, RFP-TM, chloride channel 13 275 3.5E-38 T 21-04-2016 IPR021134 Bestrophin/UPF0187 SPH21_RS14505 30c54e1b39ad3107526b6bad498c7d97 296 PANTHER PTHR33281:SF3 12 281 3.3E-40 T 21-04-2016 SPH21_RS05205 1564c87e96a06b7459aa6b4daa1f9ffd 149 PANTHER PTHR32234:SF0 1 147 5.0E-20 T 21-04-2016 IPR022910 Thiol:disulphide interchange protein DsbD GO:0047134|GO:0055114 SPH21_RS05205 1564c87e96a06b7459aa6b4daa1f9ffd 149 PANTHER PTHR32234 1 147 5.0E-20 T 21-04-2016 SPH21_RS05205 1564c87e96a06b7459aa6b4daa1f9ffd 149 Gene3D G3DSA:2.60.40.1250 24 146 1.3E-6 T 21-04-2016 IPR028250 Thiol:disulfide interchange protein DsbD, N-terminal domain SPH21_RS05205 1564c87e96a06b7459aa6b4daa1f9ffd 149 Pfam PF11412 Disulphide bond corrector protein DsbC 34 145 7.0E-16 T 21-04-2016 IPR028250 Thiol:disulfide interchange protein DsbD, N-terminal domain SPH21_RS08040 31c4dda08d09a95ee45f19818726660b 257 PANTHER PTHR22916 11 248 2.2E-66 T 21-04-2016 SPH21_RS08040 31c4dda08d09a95ee45f19818726660b 257 Gene3D G3DSA:3.90.550.10 11 229 2.0E-41 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08040 31c4dda08d09a95ee45f19818726660b 257 Pfam PF00535 Glycosyl transferase family 2 14 110 2.5E-23 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS08040 31c4dda08d09a95ee45f19818726660b 257 SUPERFAMILY SSF53448 11 224 1.13E-42 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08040 31c4dda08d09a95ee45f19818726660b 257 PANTHER PTHR22916:SF4 11 248 2.2E-66 T 21-04-2016 SPH21_RS19725 40f8df020cc0acb5e389e0de1ad14307 308 Pfam PF01062 Bestrophin, RFP-TM, chloride channel 22 281 2.4E-33 T 21-04-2016 IPR021134 Bestrophin/UPF0187 SPH21_RS19725 40f8df020cc0acb5e389e0de1ad14307 308 PANTHER PTHR33281 20 307 6.8E-47 T 21-04-2016 SPH21_RS15355 8ebcba9b7ef82be74d946d5b3fa5db9d 423 SUPERFAMILY SSF50630 170 243 6.38E-6 T 21-04-2016 IPR021109 Aspartic peptidase domain SPH21_RS15355 8ebcba9b7ef82be74d946d5b3fa5db9d 423 ProSitePatterns PS00141 Eukaryotic and viral aspartyl proteases active site. 183 194 - T 21-04-2016 IPR001969 Aspartic peptidase, active site GO:0004190|GO:0006508 SPH21_RS15355 8ebcba9b7ef82be74d946d5b3fa5db9d 423 Pfam PF13650 Aspartyl protease 172 267 1.4E-10 T 21-04-2016 SPH21_RS24595 e61c9daf2432bc40cc20e1fb77a0b0c1 82 PANTHER PTHR30547 1 82 1.1E-15 T 21-04-2016 SPH21_RS24595 e61c9daf2432bc40cc20e1fb77a0b0c1 82 PANTHER PTHR30547:SF5 1 82 1.1E-15 T 21-04-2016 SPH21_RS24595 e61c9daf2432bc40cc20e1fb77a0b0c1 82 Pfam PF06250 Protein of unknown function (DUF1016) 4 74 2.2E-18 T 21-04-2016 IPR009362 Protein of unknown function DUF1016 SPH21_RS12815 fe5d5b6c6f3fe7939185d3ba2efca1f3 134 Pfam PF08818 Domain of unknown function (DU1801) 21 112 2.5E-9 T 21-04-2016 IPR014922 Domain of unknown function DUF1801 SPH21_RS12815 fe5d5b6c6f3fe7939185d3ba2efca1f3 134 SUPERFAMILY SSF159888 8 120 1.96E-11 T 21-04-2016 SPH21_RS24340 b58adb9d864d958672f0cd7042e84379 500 SUPERFAMILY SSF88723 1 127 1.46E-6 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS24340 b58adb9d864d958672f0cd7042e84379 500 Gene3D G3DSA:3.40.50.1010 2 126 1.9E-4 T 21-04-2016 IPR029060 PIN domain-like SPH21_RS24340 b58adb9d864d958672f0cd7042e84379 500 Gene3D G3DSA:3.10.590.10 376 490 4.0E-4 T 21-04-2016 IPR002740 EVE domain SPH21_RS06630 2e6cf2d15c73562d0e0f00955fd368e2 556 PANTHER PTHR11819:SF7 5 517 2.8E-133 T 21-04-2016 SPH21_RS06630 2e6cf2d15c73562d0e0f00955fd368e2 556 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 40 455 1.7E-95 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS06630 2e6cf2d15c73562d0e0f00955fd368e2 556 Pfam PF00474 Sodium:solute symporter family 40 455 2.9E-62 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS06630 2e6cf2d15c73562d0e0f00955fd368e2 556 PANTHER PTHR11819 5 517 2.8E-133 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS20660 5538f5de1c07ba5bdd11e7ec25b049f3 121 Gene3D G3DSA:1.10.10.10 8 118 4.2E-30 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20660 5538f5de1c07ba5bdd11e7ec25b049f3 121 PANTHER PTHR33204 21 116 2.1E-24 T 21-04-2016 SPH21_RS20660 5538f5de1c07ba5bdd11e7ec25b049f3 121 Pfam PF01638 HxlR-like helix-turn-helix 26 114 2.1E-23 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS20660 5538f5de1c07ba5bdd11e7ec25b049f3 121 SUPERFAMILY SSF46785 13 117 1.41E-23 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS25235 efbbb7d3bb09fa207dec42c85a196d03 66 PANTHER PTHR40069:SF1 1 66 1.3E-20 T 21-04-2016 SPH21_RS25235 efbbb7d3bb09fa207dec42c85a196d03 66 Pfam PF09962 Uncharacterized conserved protein (DUF2196) 3 63 1.5E-27 T 21-04-2016 IPR019240 Protein of unknown function DUF2196 SPH21_RS25235 efbbb7d3bb09fa207dec42c85a196d03 66 TIGRFAM TIGR03833 TIGR03833: conserved hypothetical protein 3 63 2.4E-29 T 21-04-2016 IPR019240 Protein of unknown function DUF2196 SPH21_RS25235 efbbb7d3bb09fa207dec42c85a196d03 66 PANTHER PTHR40069 1 66 1.3E-20 T 21-04-2016 SPH21_RS01255 b8647a996aad98c5640918e568bbc4dd 81 SUPERFAMILY SSF47789 16 80 1.01E-5 T 21-04-2016 SPH21_RS24785 393629b73eed37d71fcabb73d1212cfd 602 Pfam PF02687 FtsX-like permease family 98 208 1.2E-15 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS24785 393629b73eed37d71fcabb73d1212cfd 602 Pfam PF02687 FtsX-like permease family 483 593 1.3E-9 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS24785 393629b73eed37d71fcabb73d1212cfd 602 PANTHER PTHR30572:SF4 86 165 1.1E-65 T 21-04-2016 SPH21_RS24785 393629b73eed37d71fcabb73d1212cfd 602 PANTHER PTHR30572:SF4 209 602 1.1E-65 T 21-04-2016 SPH21_RS24785 393629b73eed37d71fcabb73d1212cfd 602 PANTHER PTHR30572 86 165 1.1E-65 T 21-04-2016 SPH21_RS24785 393629b73eed37d71fcabb73d1212cfd 602 PANTHER PTHR30572 209 602 1.1E-65 T 21-04-2016 SPH21_RS19430 cf0b9a34169e697d08c9747c7ed7bb53 571 Gene3D G3DSA:2.70.70.10 20 171 5.4E-32 T 21-04-2016 SPH21_RS19430 cf0b9a34169e697d08c9747c7ed7bb53 571 SUPERFAMILY SSF51261 31 170 3.92E-29 T 21-04-2016 IPR011055 Duplicated hybrid motif SPH21_RS19430 cf0b9a34169e697d08c9747c7ed7bb53 571 Pfam PF01551 Peptidase family M23 56 123 2.6E-11 T 21-04-2016 IPR016047 Peptidase M23 SPH21_RS19430 cf0b9a34169e697d08c9747c7ed7bb53 571 Pfam PF01551 Peptidase family M23 143 171 1.2E-6 T 21-04-2016 IPR016047 Peptidase M23 SPH21_RS19430 cf0b9a34169e697d08c9747c7ed7bb53 571 PANTHER PTHR21666 143 168 2.4E-25 T 21-04-2016 SPH21_RS19430 cf0b9a34169e697d08c9747c7ed7bb53 571 PANTHER PTHR21666 33 125 2.4E-25 T 21-04-2016 SPH21_RS07365 aa1f492e27d407b16b01cf3248ed95de 119 Gene3D G3DSA:3.10.450.50 6 118 1.4E-16 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS07365 aa1f492e27d407b16b01cf3248ed95de 119 Pfam PF12680 SnoaL-like domain 12 91 3.0E-11 T 21-04-2016 IPR009959 Polyketide cyclase SnoaL-like domain SPH21_RS07365 aa1f492e27d407b16b01cf3248ed95de 119 SUPERFAMILY SSF54427 11 117 1.46E-16 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS12480 3ee9656700c74080727fc90da18dc9b0 951 Gene3D G3DSA:2.120.10.30 338 578 3.1E-18 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS12480 3ee9656700c74080727fc90da18dc9b0 951 SUPERFAMILY SSF82171 317 465 4.32E-14 T 21-04-2016 SPH21_RS12480 3ee9656700c74080727fc90da18dc9b0 951 SUPERFAMILY SSF82171 509 576 4.32E-14 T 21-04-2016 SPH21_RS15350 9086bad83643fd98b76c95fdbdf6fb84 140 Pfam PF13673 Acetyltransferase (GNAT) domain 52 128 8.6E-12 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS15350 9086bad83643fd98b76c95fdbdf6fb84 140 PANTHER PTHR13355 41 137 6.7E-17 T 21-04-2016 SPH21_RS15350 9086bad83643fd98b76c95fdbdf6fb84 140 Gene3D G3DSA:3.40.630.30 17 135 2.8E-25 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15350 9086bad83643fd98b76c95fdbdf6fb84 140 SUPERFAMILY SSF55729 18 128 1.08E-18 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS15350 9086bad83643fd98b76c95fdbdf6fb84 140 PANTHER PTHR13355:SF5 41 137 6.7E-17 T 21-04-2016 SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 PANTHER PTHR35004 5 84 4.2E-69 T 21-04-2016 SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 PANTHER PTHR35004 102 459 4.2E-69 T 21-04-2016 SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 Gene3D G3DSA:1.10.10.10 12 42 2.6E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 Pfam PF00665 Integrase core domain 139 265 1.3E-15 T 21-04-2016 IPR001584 Integrase, catalytic core GO:0015074 SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 Gene3D G3DSA:3.30.420.10 167 296 6.3E-10 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 SUPERFAMILY SSF53098 167 297 8.35E-11 T 21-04-2016 IPR012337 Ribonuclease H-like domain GO:0003676 SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 PANTHER PTHR35004:SF2 5 84 4.2E-69 T 21-04-2016 SPH21_RS20290 f9d72e6130c27e656be00761c40df827 517 PANTHER PTHR35004:SF2 102 459 4.2E-69 T 21-04-2016 SPH21_RS11950 e2f6ef223392757508b0174e676bb800 159 Pfam PF14126 Domain of unknown function (DUF4293) 2 158 2.1E-35 T 21-04-2016 IPR025635 Protein of unknown function DUF4293 SPH21_RS06195 7070f7f4cdb73fbe26fece881d045137 190 Gene3D G3DSA:3.90.470.20 33 107 2.3E-7 T 21-04-2016 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SPH21_RS10425 8f9d817d0b4d8963beea39412cd9ca05 1337 PANTHER PTHR23304:SF113 135 1208 1.2E-276 T 21-04-2016 SPH21_RS10425 8f9d817d0b4d8963beea39412cd9ca05 1337 Pfam PF02514 CobN/Magnesium Chelatase 134 1174 9.7E-280 T 21-04-2016 IPR003672 CobN/magnesium chelatase GO:0009058 SPH21_RS10425 8f9d817d0b4d8963beea39412cd9ca05 1337 PANTHER PTHR23304 135 1208 1.2E-276 T 21-04-2016 SPH21_RS04960 442685a6d91bc08b6712d8e957e5d3ad 352 Gene3D G3DSA:1.50.10.10 10 76 6.5E-6 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS04960 442685a6d91bc08b6712d8e957e5d3ad 352 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 13 69 2.0E-8 T 21-04-2016 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS08800 95f81bb30826f0b8954a3ae0306a89d4 481 Pfam PF13440 Polysaccharide biosynthesis protein 32 323 2.7E-91 T 21-04-2016 SPH21_RS08800 95f81bb30826f0b8954a3ae0306a89d4 481 PANTHER PTHR30250 1 477 2.0E-81 T 21-04-2016 SPH21_RS08800 95f81bb30826f0b8954a3ae0306a89d4 481 PANTHER PTHR30250:SF0 1 477 2.0E-81 T 21-04-2016 SPH21_RS26295 b3a1861519fce1f5444dbc6256553ba0 383 Pfam PF04773 FecR protein 184 271 1.1E-16 T 21-04-2016 IPR006860 FecR protein SPH21_RS26295 b3a1861519fce1f5444dbc6256553ba0 383 PANTHER PTHR30273 179 371 9.9E-53 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26295 b3a1861519fce1f5444dbc6256553ba0 383 PANTHER PTHR30273 1 124 9.9E-53 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS26295 b3a1861519fce1f5444dbc6256553ba0 383 PANTHER PTHR30273:SF2 179 371 9.9E-53 T 21-04-2016 SPH21_RS26295 b3a1861519fce1f5444dbc6256553ba0 383 PANTHER PTHR30273:SF2 1 124 9.9E-53 T 21-04-2016 SPH21_RS26295 b3a1861519fce1f5444dbc6256553ba0 383 Pfam PF16344 Domain of unknown function (DUF4974) 282 371 4.1E-12 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS13395 1e8afd34cade50672aa3d82489f7aa70 131 Pfam PF11236 Protein of unknown function (DUF3037) 13 130 1.7E-43 T 21-04-2016 IPR021398 Protein of unknown function DUF3037 SPH21_RS03975 b2870c191d34fa980dc888dbbe61545e 530 SUPERFAMILY SSF48452 32 530 1.09E-118 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03975 b2870c191d34fa980dc888dbbe61545e 530 Pfam PF07980 SusD family 275 530 1.9E-43 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS03975 b2870c191d34fa980dc888dbbe61545e 530 Pfam PF14322 Starch-binding associating with outer membrane 37 234 1.3E-28 T 21-04-2016 SPH21_RS03975 b2870c191d34fa980dc888dbbe61545e 530 Gene3D G3DSA:1.25.40.10 377 464 1.0E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03975 b2870c191d34fa980dc888dbbe61545e 530 Gene3D G3DSA:1.25.40.10 218 334 1.0E-37 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10325 fcbffee995ead6116511a98367436e92 90 Pfam PF12732 YtxH-like protein 8 76 2.8E-11 T 21-04-2016 IPR024623 Uncharacterised protein family YtxH SPH21_RS10325 fcbffee995ead6116511a98367436e92 90 Gene3D G3DSA:3.90.226.10 6 89 1.9E-5 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS01340 9652255aa61473b0708c71bea95b03e8 363 Pfam PF04235 Protein of unknown function (DUF418) 213 363 4.1E-22 T 21-04-2016 IPR007349 Domain of unknown function DUF418 SPH21_RS01340 9652255aa61473b0708c71bea95b03e8 363 PANTHER PTHR30590 11 362 2.3E-40 T 21-04-2016 SPH21_RS10965 84936370366a7dfb8b656b97b5a72040 572 Pfam PF00593 TonB dependent receptor 382 570 9.3E-10 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10965 84936370366a7dfb8b656b97b5a72040 572 Gene3D G3DSA:2.40.170.20 381 572 6.6E-15 T 21-04-2016 IPR000531 TonB-dependent receptor, beta-barrel GO:0004872|GO:0006810|GO:0016020 SPH21_RS10965 84936370366a7dfb8b656b97b5a72040 572 SUPERFAMILY SSF56935 142 270 2.01E-16 T 21-04-2016 SPH21_RS10965 84936370366a7dfb8b656b97b5a72040 572 SUPERFAMILY SSF56935 312 572 2.01E-16 T 21-04-2016 SPH21_RS06570 6fc7bbf839350f560fa4e1f707168e39 293 PANTHER PTHR33281 3 292 2.0E-64 T 21-04-2016 SPH21_RS06570 6fc7bbf839350f560fa4e1f707168e39 293 Pfam PF01062 Bestrophin, RFP-TM, chloride channel 12 282 6.0E-46 T 21-04-2016 IPR021134 Bestrophin/UPF0187 SPH21_RS20410 af4e4823146532d30654c082a013b019 97 Gene3D G3DSA:3.40.720.10 18 94 1.4E-14 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS20410 af4e4823146532d30654c082a013b019 97 SUPERFAMILY SSF53649 15 92 1.23E-14 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS07355 fd9bf3f42c4896fd8e9c1fb1def5e8ea 152 PANTHER PTHR23091 2 152 2.3E-27 T 21-04-2016 SPH21_RS07355 fd9bf3f42c4896fd8e9c1fb1def5e8ea 152 Gene3D G3DSA:3.40.630.30 1 149 4.8E-29 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS07355 fd9bf3f42c4896fd8e9c1fb1def5e8ea 152 Pfam PF00583 Acetyltransferase (GNAT) family 56 131 3.5E-14 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS07355 fd9bf3f42c4896fd8e9c1fb1def5e8ea 152 SUPERFAMILY SSF55729 13 140 2.57E-25 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS07355 fd9bf3f42c4896fd8e9c1fb1def5e8ea 152 PANTHER PTHR23091:SF265 2 152 2.3E-27 T 21-04-2016 SPH21_RS10540 10767ffb9b63e6066d028e486a795f03 358 Pfam PF01594 Domain of unknown function DUF20 11 330 1.6E-52 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS10540 10767ffb9b63e6066d028e486a795f03 358 PANTHER PTHR21716 11 350 4.7E-56 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS00905 947fcb1bcf2ae75827c2ab663b3230da 259 Pfam PF13852 Protein of unknown function (DUF4197) 59 256 3.2E-75 T 21-04-2016 IPR025245 Protein of unknown function DUF4197 SPH21_RS04710 d32e04e7fd0adc35f165f2f9b11752e4 134 PIRSF PIRSF030066 1 134 1.1E-41 T 21-04-2016 IPR016944 Uncharacterised conserved protein UCP030066 SPH21_RS04710 d32e04e7fd0adc35f165f2f9b11752e4 134 Pfam PF13564 DoxX-like family 18 118 6.3E-21 T 21-04-2016 IPR032808 DoxX family SPH21_RS19850 65c542243e650c851c4ae6e36c641686 239 Pfam PF02535 ZIP Zinc transporter 3 92 1.2E-8 T 21-04-2016 IPR003689 Zinc/iron permease GO:0016020|GO:0030001|GO:0046873|GO:0055085 SPH21_RS19850 65c542243e650c851c4ae6e36c641686 239 Pfam PF02535 ZIP Zinc transporter 102 232 5.6E-13 T 21-04-2016 IPR003689 Zinc/iron permease GO:0016020|GO:0030001|GO:0046873|GO:0055085 SPH21_RS19850 65c542243e650c851c4ae6e36c641686 239 PANTHER PTHR11040 3 168 2.5E-13 T 21-04-2016 SPH21_RS20280 1416a1227ac713572aaaab9244806223 81 Pfam PF08818 Domain of unknown function (DU1801) 17 77 3.4E-8 T 21-04-2016 IPR014922 Domain of unknown function DUF1801 SPH21_RS20280 1416a1227ac713572aaaab9244806223 81 SUPERFAMILY SSF159888 5 77 4.71E-18 T 21-04-2016 SPH21_RS11165 853ea57e763853bceda1f2780e6391a7 478 Pfam PF14322 Starch-binding associating with outer membrane 54 203 2.3E-25 T 21-04-2016 SPH21_RS11165 853ea57e763853bceda1f2780e6391a7 478 Pfam PF07980 SusD family 245 478 4.9E-37 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS11165 853ea57e763853bceda1f2780e6391a7 478 SUPERFAMILY SSF48452 5 478 1.61E-121 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS11165 853ea57e763853bceda1f2780e6391a7 478 Gene3D G3DSA:1.25.40.10 183 419 9.1E-44 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09950 599d57b5167821c4daae93d54b87cf16 320 Pfam PF00881 Nitroreductase family 219 298 1.4E-10 T 21-04-2016 IPR029479 Nitroreductase SPH21_RS09950 599d57b5167821c4daae93d54b87cf16 320 Pfam PF00881 Nitroreductase family 154 198 1.8E-10 T 21-04-2016 IPR029479 Nitroreductase SPH21_RS09950 599d57b5167821c4daae93d54b87cf16 320 PANTHER PTHR23026 126 320 3.6E-30 T 21-04-2016 SPH21_RS09950 599d57b5167821c4daae93d54b87cf16 320 Gene3D G3DSA:3.40.109.10 143 319 1.0E-34 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS09950 599d57b5167821c4daae93d54b87cf16 320 SUPERFAMILY SSF55469 147 320 2.22E-36 T 21-04-2016 IPR000415 Nitroreductase-like GO:0016491 SPH21_RS09950 599d57b5167821c4daae93d54b87cf16 320 PANTHER PTHR23026:SF90 126 320 3.6E-30 T 21-04-2016 SPH21_RS05030 a5af7d82b5fbf2cd91c7350286ac66c5 113 Pfam PF04616 Glycosyl hydrolases family 43 26 74 8.9E-8 T 21-04-2016 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SPH21_RS05030 a5af7d82b5fbf2cd91c7350286ac66c5 113 Gene3D G3DSA:2.115.10.20 8 75 1.2E-14 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS05030 a5af7d82b5fbf2cd91c7350286ac66c5 113 SUPERFAMILY SSF75005 7 75 1.28E-14 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS00890 3b6b98bc5a10aaf25432cb798ef3a159 421 Pfam PF14298 Domain of unknown function (DUF4374) 220 408 1.3E-52 T 21-04-2016 IPR025401 Protein of unknown function DUF4374 SPH21_RS00890 3b6b98bc5a10aaf25432cb798ef3a159 421 Pfam PF14298 Domain of unknown function (DUF4374) 23 210 5.2E-24 T 21-04-2016 IPR025401 Protein of unknown function DUF4374 SPH21_RS19110 52a109ca8fb166146323a1ef5eff8b52 404 SUPERFAMILY SSF103473 20 397 1.31E-36 T 21-04-2016 IPR020846 Major facilitator superfamily domain SPH21_RS19110 52a109ca8fb166146323a1ef5eff8b52 404 PANTHER PTHR23514 13 395 6.9E-115 T 21-04-2016 SPH21_RS19110 52a109ca8fb166146323a1ef5eff8b52 404 PANTHER PTHR23514:SF13 13 395 6.9E-115 T 21-04-2016 SPH21_RS19110 52a109ca8fb166146323a1ef5eff8b52 404 Pfam PF07690 Major Facilitator Superfamily 22 327 1.0E-16 T 21-04-2016 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SPH21_RS19110 52a109ca8fb166146323a1ef5eff8b52 404 Gene3D G3DSA:1.20.1250.20 22 182 9.6E-17 T 21-04-2016 SPH21_RS19110 52a109ca8fb166146323a1ef5eff8b52 404 Gene3D G3DSA:1.20.1250.20 218 401 6.8E-13 T 21-04-2016 SPH21_RS08865 d877eac492c1c0cad0f851bde84bdec7 547 Pfam PF14052 Capsule assembly protein Wzi 183 511 7.1E-13 T 21-04-2016 IPR026950 Capsule assembly protein Wzi SPH21_RS00390 18de2b3730df31624019628f966d49df 116 Gene3D G3DSA:3.10.180.10 1 115 4.1E-29 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS00390 18de2b3730df31624019628f966d49df 116 SUPERFAMILY SSF54593 5 114 1.34E-22 T 21-04-2016 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SPH21_RS00390 18de2b3730df31624019628f966d49df 116 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 12 110 2.1E-9 T 21-04-2016 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SPH21_RS04715 a0cf5293fefc39535cb4c509eb49065e 199 Pfam PF13376 Bacteriocin-protection, YdeI or OmpD-Associated 136 194 3.0E-19 T 21-04-2016 SPH21_RS04715 a0cf5293fefc39535cb4c509eb49065e 199 Pfam PF08818 Domain of unknown function (DU1801) 15 119 8.5E-16 T 21-04-2016 IPR014922 Domain of unknown function DUF1801 SPH21_RS04715 a0cf5293fefc39535cb4c509eb49065e 199 PIRSF PIRSF021308 1 199 1.3E-85 T 21-04-2016 IPR016786 Uncharacterised protein YdeI, bacterial SPH21_RS04715 a0cf5293fefc39535cb4c509eb49065e 199 SUPERFAMILY SSF159888 6 128 1.44E-18 T 21-04-2016 SPH21_RS03365 2d4c4e00eb044827e97320b904b59eb5 235 SUPERFAMILY SSF48452 126 224 7.59E-10 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03365 2d4c4e00eb044827e97320b904b59eb5 235 Pfam PF13432 Tetratricopeptide repeat 130 188 7.6E-6 T 21-04-2016 SPH21_RS03365 2d4c4e00eb044827e97320b904b59eb5 235 Gene3D G3DSA:1.25.40.10 129 223 2.5E-7 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03200 b5c81370ccc1a6572bcac9e2d5da185f 205 PANTHER PTHR10655 21 201 2.0E-22 T 21-04-2016 SPH21_RS03200 b5c81370ccc1a6572bcac9e2d5da185f 205 Gene3D G3DSA:3.40.50.1820 16 205 2.3E-29 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS03200 b5c81370ccc1a6572bcac9e2d5da185f 205 SUPERFAMILY SSF53474 12 205 1.68E-32 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS03200 b5c81370ccc1a6572bcac9e2d5da185f 205 Pfam PF02230 Phospholipase/Carboxylesterase 19 202 5.0E-22 T 21-04-2016 IPR003140 Phospholipase/carboxylesterase/thioesterase GO:0016787 SPH21_RS09955 2e976a601825cba69ba08b291c14747c 384 PANTHER PTHR36836 1 384 2.8E-17 T 21-04-2016 SPH21_RS09955 2e976a601825cba69ba08b291c14747c 384 Pfam PF04230 Polysaccharide pyruvyl transferase 15 314 5.3E-36 T 21-04-2016 IPR007345 Polysaccharide pyruvyl transferase SPH21_RS18295 eed179fffab77ae71f1a8e49f8b7d59b 260 PANTHER PTHR30164 1 260 7.7E-58 T 21-04-2016 SPH21_RS18295 eed179fffab77ae71f1a8e49f8b7d59b 260 Gene3D G3DSA:3.40.390.10 46 257 2.3E-46 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS18295 eed179fffab77ae71f1a8e49f8b7d59b 260 SUPERFAMILY SSF55486 59 257 1.68E-44 T 21-04-2016 SPH21_RS18295 eed179fffab77ae71f1a8e49f8b7d59b 260 Pfam PF06167 Glucose-regulated metallo-peptidase M90 24 256 3.6E-66 T 21-04-2016 IPR010384 MtfA family SPH21_RS00225 79405b923e99cc34fe8180ef584a5d2d 236 PANTHER PTHR34387 4 236 2.5E-18 T 21-04-2016 SPH21_RS00225 79405b923e99cc34fe8180ef584a5d2d 236 Pfam PF04402 Protein of unknown function (DUF541) 28 233 1.2E-30 T 21-04-2016 IPR007497 Protein of unknown function DUF541 SPH21_RS00225 79405b923e99cc34fe8180ef584a5d2d 236 PANTHER PTHR34387:SF1 4 236 2.5E-18 T 21-04-2016 SPH21_RS22030 4a90003e00a70d4a49bb07ea0acdaa82 119 SUPERFAMILY SSF46785 9 108 4.69E-28 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS22030 4a90003e00a70d4a49bb07ea0acdaa82 119 Pfam PF01638 HxlR-like helix-turn-helix 21 108 1.4E-28 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS22030 4a90003e00a70d4a49bb07ea0acdaa82 119 PANTHER PTHR33204 1 114 1.1E-33 T 21-04-2016 SPH21_RS22030 4a90003e00a70d4a49bb07ea0acdaa82 119 Gene3D G3DSA:1.10.10.10 4 110 2.2E-33 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS24860 36e0865241aaf5345285217170565d99 140 SUPERFAMILY SSF55961 5 138 6.68E-30 T 21-04-2016 SPH21_RS24860 36e0865241aaf5345285217170565d99 140 Gene3D G3DSA:3.30.530.20 4 138 2.2E-23 T 21-04-2016 IPR023393 START-like domain SPH21_RS24860 36e0865241aaf5345285217170565d99 140 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 14 137 3.0E-19 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS24860 36e0865241aaf5345285217170565d99 140 PANTHER PTHR36929 6 137 3.3E-20 T 21-04-2016 SPH21_RS24860 36e0865241aaf5345285217170565d99 140 PANTHER PTHR36929:SF1 6 137 3.3E-20 T 21-04-2016 SPH21_RS08225 23f8c9c6e7b4fdf7864461c916dc89c0 331 PANTHER PTHR30273 1 330 3.2E-61 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS08225 23f8c9c6e7b4fdf7864461c916dc89c0 331 Pfam PF16344 Domain of unknown function (DUF4974) 224 324 1.0E-20 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS08225 23f8c9c6e7b4fdf7864461c916dc89c0 331 PIRSF PIRSF018266 1 326 4.8E-62 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS08225 23f8c9c6e7b4fdf7864461c916dc89c0 331 Pfam PF04773 FecR protein 123 212 2.4E-19 T 21-04-2016 IPR006860 FecR protein SPH21_RS08225 23f8c9c6e7b4fdf7864461c916dc89c0 331 PANTHER PTHR30273:SF2 1 330 3.2E-61 T 21-04-2016 SPH21_RS26385 bebf0f0d779ab188d20ebc1cc5275060 87 Pfam PF02230 Phospholipase/Carboxylesterase 13 74 4.0E-5 T 21-04-2016 IPR003140 Phospholipase/carboxylesterase/thioesterase GO:0016787 SPH21_RS26385 bebf0f0d779ab188d20ebc1cc5275060 87 Gene3D G3DSA:3.40.50.1820 8 76 6.1E-11 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS26385 bebf0f0d779ab188d20ebc1cc5275060 87 SUPERFAMILY SSF53474 8 77 1.11E-9 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS12550 25913152fd60c88759fbda72396af6b7 129 PANTHER PTHR33495 1 115 4.5E-12 T 21-04-2016 SPH21_RS12550 25913152fd60c88759fbda72396af6b7 129 SUPERFAMILY SSF52091 1 108 8.63E-17 T 21-04-2016 IPR002645 STAS domain SPH21_RS12550 25913152fd60c88759fbda72396af6b7 129 Gene3D G3DSA:3.30.750.24 1 108 1.8E-18 T 21-04-2016 IPR002645 STAS domain SPH21_RS12550 25913152fd60c88759fbda72396af6b7 129 Pfam PF01740 STAS domain 39 107 1.7E-6 T 21-04-2016 IPR002645 STAS domain SPH21_RS04445 1063e9ef42a26d35123f2ad0c8acb9de 191 Gene3D G3DSA:2.60.120.10 4 146 3.6E-30 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS04445 1063e9ef42a26d35123f2ad0c8acb9de 191 PANTHER PTHR24567 16 187 6.4E-12 T 21-04-2016 SPH21_RS04445 1063e9ef42a26d35123f2ad0c8acb9de 191 SUPERFAMILY SSF51206 18 146 7.59E-21 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS04445 1063e9ef42a26d35123f2ad0c8acb9de 191 PANTHER PTHR24567:SF33 16 187 6.4E-12 T 21-04-2016 SPH21_RS04445 1063e9ef42a26d35123f2ad0c8acb9de 191 Pfam PF00027 Cyclic nucleotide-binding domain 32 117 1.5E-8 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS21405 814c95703d7fc254d5a7af5a9543d20f 445 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 178 193 - T 21-04-2016 IPR019826 Carboxylesterase type B, active site SPH21_RS21405 814c95703d7fc254d5a7af5a9543d20f 445 SUPERFAMILY SSF53474 4 426 8.51E-75 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS21405 814c95703d7fc254d5a7af5a9543d20f 445 PANTHER PTHR11559 7 425 3.8E-84 T 21-04-2016 SPH21_RS21405 814c95703d7fc254d5a7af5a9543d20f 445 Pfam PF00135 Carboxylesterase family 6 316 7.2E-65 T 21-04-2016 IPR002018 Carboxylesterase, type B SPH21_RS21405 814c95703d7fc254d5a7af5a9543d20f 445 Pfam PF00135 Carboxylesterase family 334 426 4.8E-5 T 21-04-2016 IPR002018 Carboxylesterase, type B SPH21_RS21405 814c95703d7fc254d5a7af5a9543d20f 445 Gene3D G3DSA:3.40.50.1820 7 426 5.9E-86 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS21980 dc12af402f1c59a2666bd59f87e1c494 117 Pfam PF12973 ChrR Cupin-like domain 26 107 1.1E-18 T 21-04-2016 IPR025979 ChrR-like cupin domain SPH21_RS21980 dc12af402f1c59a2666bd59f87e1c494 117 Gene3D G3DSA:2.60.120.10 14 109 3.3E-22 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS21980 dc12af402f1c59a2666bd59f87e1c494 117 SUPERFAMILY SSF51182 8 109 3.82E-23 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS03820 d00ab7dd729b6d4fc0cb09a0816543db 262 Gene3D G3DSA:3.30.2010.10 67 142 4.8E-17 T 21-04-2016 SPH21_RS03820 d00ab7dd729b6d4fc0cb09a0816543db 262 PANTHER PTHR22726 1 255 1.4E-81 T 21-04-2016 SPH21_RS03820 d00ab7dd729b6d4fc0cb09a0816543db 262 PANTHER PTHR22726:SF4 1 255 1.4E-81 T 21-04-2016 SPH21_RS03820 d00ab7dd729b6d4fc0cb09a0816543db 262 Pfam PF01435 Peptidase family M48 81 250 1.1E-24 T 21-04-2016 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SPH21_RS13850 165afc9619f93b4de3e03be5c188975e 286 Gene3D G3DSA:3.40.50.1820 3 284 3.6E-33 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13850 165afc9619f93b4de3e03be5c188975e 286 SUPERFAMILY SSF53474 3 284 1.49E-37 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS13850 165afc9619f93b4de3e03be5c188975e 286 Pfam PF00561 alpha/beta hydrolase fold 31 164 3.6E-7 T 21-04-2016 IPR000073 Alpha/beta hydrolase fold-1 SPH21_RS19650 463e2aef95de0f723ec6c515b78d19ed 288 Pfam PF06439 Domain of Unknown Function (DUF1080) 35 262 5.7E-32 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS17895 d11ef2e71c759ac91f4beee0f0299589 243 Pfam PF10677 Protein of unknown function (DUF2490) 27 211 4.9E-22 T 21-04-2016 IPR019619 Protein of unknown function DUF2490 SPH21_RS25805 e660e59b60c4858e69d6e5c5b9730eb2 288 TIGRFAM TIGR03523 GldN: gliding motility associated protein GldN 42 288 3.5E-51 T 21-04-2016 IPR019847 Gliding motility associated protein GldN SPH21_RS00770 fa1dd6b64000c72a5901f53bfce6150b 130 SUPERFAMILY SSF47413 7 75 1.56E-13 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS00770 fa1dd6b64000c72a5901f53bfce6150b 130 SMART SM00530 14 70 2.9E-10 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS00770 fa1dd6b64000c72a5901f53bfce6150b 130 Gene3D G3DSA:1.10.260.40 10 113 1.3E-17 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS00770 fa1dd6b64000c72a5901f53bfce6150b 130 Pfam PF01381 Helix-turn-helix 15 70 4.5E-14 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS09885 83ceb3d7b1068c5b2ba7b89a84a47552 305 SUPERFAMILY SSF53448 4 282 1.19E-20 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09885 83ceb3d7b1068c5b2ba7b89a84a47552 305 Gene3D G3DSA:3.90.550.10 5 278 2.4E-19 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS09885 83ceb3d7b1068c5b2ba7b89a84a47552 305 Pfam PF00483 Nucleotidyl transferase 29 222 7.5E-9 T 21-04-2016 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 Reactome: REACT_17015 SPH21_RS22685 365b3dd25b528246a94254674ef23125 315 SUPERFAMILY SSF52317 209 313 6.64E-9 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS22685 365b3dd25b528246a94254674ef23125 315 SUPERFAMILY SSF52317 44 179 6.64E-9 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS21910 36db2054754260bf80153ed35cc50c40 128 Pfam PF01638 HxlR-like helix-turn-helix 29 116 2.0E-10 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS21910 36db2054754260bf80153ed35cc50c40 128 Gene3D G3DSA:1.10.10.10 17 122 2.2E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS21910 36db2054754260bf80153ed35cc50c40 128 SUPERFAMILY SSF46785 18 122 3.69E-17 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS08135 811827fd7ad8f3be21fe6585ba39338d 166 Pfam PF01050 Mannose-6-phosphate isomerase 62 162 2.9E-8 T 21-04-2016 IPR001538 Mannose-6-phosphate isomerase, type II, C-terminal GO:0005976|GO:0016779 KEGG: 00051+2.7.7.13|KEGG: 00520+2.7.7.13|MetaCyc: PWY-5659|MetaCyc: PWY-882|UniPathway: UPA00126 SPH21_RS08135 811827fd7ad8f3be21fe6585ba39338d 166 Gene3D G3DSA:2.60.120.10 53 166 6.3E-12 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS08135 811827fd7ad8f3be21fe6585ba39338d 166 SUPERFAMILY SSF51182 51 166 4.15E-15 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS20165 f665e7ed46c5c5512c10a47846ead845 252 Pfam PF13566 Domain of unknown function (DUF4130 84 249 2.1E-49 T 21-04-2016 IPR025404 Domain of unknown function DUF4130 SPH21_RS20165 f665e7ed46c5c5512c10a47846ead845 252 TIGRFAM TIGR03915 SAM_7_link_chp: probable DNA metabolism protein 5 250 5.0E-78 T 21-04-2016 IPR023875 DNA metabolism protein, putative SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 Pfam PF00557 Metallopeptidase family M24 13 240 1.1E-48 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 PANTHER PTHR10804 5 248 3.2E-104 T 21-04-2016 SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 6 249 5.6E-90 T 21-04-2016 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 PRINTS PR00599 Methionine aminopeptidase-1 signature 192 204 6.2E-20 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 PRINTS PR00599 Methionine aminopeptidase-1 signature 161 173 6.2E-20 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 PRINTS PR00599 Methionine aminopeptidase-1 signature 91 107 6.2E-20 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 PRINTS PR00599 Methionine aminopeptidase-1 signature 69 82 6.2E-20 T 21-04-2016 IPR001714 Peptidase M24, methionine aminopeptidase SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 SUPERFAMILY SSF55920 6 251 1.02E-77 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 Gene3D G3DSA:3.90.230.10 6 252 4.4E-81 T 21-04-2016 IPR000994 Peptidase M24, structural domain SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 PANTHER PTHR10804:SF41 5 248 3.2E-104 T 21-04-2016 SPH21_RS08600 13297693c21a7ab5f0ffe34806b37ffe 261 Hamap MF_01974 Methionine aminopeptidase [map]. 4 250 37.686 T 21-04-2016 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SPH21_RS00545 92846ea3be9b37780d95f7ac4f68438b 408 Gene3D G3DSA:1.50.10.10 2 388 1.7E-124 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS00545 92846ea3be9b37780d95f7ac4f68438b 408 Pfam PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) 33 368 3.3E-81 T 21-04-2016 SPH21_RS00545 92846ea3be9b37780d95f7ac4f68438b 408 SUPERFAMILY SSF48208 8 389 7.14E-93 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS00545 92846ea3be9b37780d95f7ac4f68438b 408 PANTHER PTHR15108 1 395 7.5E-149 T 21-04-2016 SPH21_RS22165 57a08aedf71e90713ccd0cef290eb70b 337 Pfam PF00487 Fatty acid desaturase 74 313 4.6E-18 T 21-04-2016 IPR005804 Fatty acid desaturase domain GO:0006629 SPH21_RS15155 36862c5ba8a2cb2297e82713dfbff57c 254 TIGRFAM TIGR00419 tim: triose-phosphate isomerase 5 243 2.8E-61 T 21-04-2016 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|UniPathway: UPA00109|UniPathway: UPA00138 SPH21_RS15155 36862c5ba8a2cb2297e82713dfbff57c 254 Gene3D G3DSA:3.20.20.70 1 252 1.0E-103 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS15155 36862c5ba8a2cb2297e82713dfbff57c 254 Hamap MF_00147_B Triosephosphate isomerase [tpiA]. 2 253 40.256 T 21-04-2016 IPR022896 Triosephosphate isomerase, bacterial/eukaryotic GO:0004807|GO:0006096 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|UniPathway: UPA00109|UniPathway: UPA00138 SPH21_RS15155 36862c5ba8a2cb2297e82713dfbff57c 254 PANTHER PTHR21139 1 251 2.6E-123 T 21-04-2016 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|UniPathway: UPA00109|UniPathway: UPA00138 SPH21_RS15155 36862c5ba8a2cb2297e82713dfbff57c 254 ProSitePatterns PS00171 Triosephosphate isomerase active site. 168 178 - T 21-04-2016 IPR020861 Triosephosphate isomerase, active site GO:0004807 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|UniPathway: UPA00109|UniPathway: UPA00138 SPH21_RS15155 36862c5ba8a2cb2297e82713dfbff57c 254 SUPERFAMILY SSF51351 1 252 7.85E-92 T 21-04-2016 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|UniPathway: UPA00109|UniPathway: UPA00138 SPH21_RS15155 36862c5ba8a2cb2297e82713dfbff57c 254 Pfam PF00121 Triosephosphate isomerase 4 250 2.2E-91 T 21-04-2016 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|UniPathway: UPA00109|UniPathway: UPA00138 SPH21_RS26455 542c1cef2949c745a65e054ab48cdc6c 218 Pfam PF14129 Domain of unknown function (DUF4296) 23 106 8.0E-23 T 21-04-2016 IPR025381 Domain of unknown function DUF4296 SPH21_RS01200 7b07100008531d96b3484695577a8bd5 203 TIGRFAM TIGR03781 Bac_Flav_CT_K: Bacteroides conjugative transposon TraK protein 6 199 3.2E-63 T 21-04-2016 IPR022276 Conjugative transposon, TraK SPH21_RS11455 6d5eca24f270f4446bf9f36853d7e503 130 Gene3D G3DSA:4.10.520.10 34 121 3.9E-7 T 21-04-2016 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SPH21_RS11455 6d5eca24f270f4446bf9f36853d7e503 130 TIGRFAM TIGR01201 HU_rel: putative DNA-binding protein 20 121 2.1E-25 T 21-04-2016 IPR005902 Putative DNA-binding protein, HU-related SPH21_RS11455 6d5eca24f270f4446bf9f36853d7e503 130 Pfam PF00216 Bacterial DNA-binding protein 37 87 4.7E-5 T 21-04-2016 IPR000119 Histone-like DNA-binding protein GO:0003677 SPH21_RS11455 6d5eca24f270f4446bf9f36853d7e503 130 SUPERFAMILY SSF47729 35 119 2.36E-9 T 21-04-2016 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SPH21_RS02780 339cf77fd04df691009b6099a47f43cc 125 Gene3D G3DSA:3.30.530.20 2 105 2.0E-12 T 21-04-2016 IPR023393 START-like domain SPH21_RS02780 339cf77fd04df691009b6099a47f43cc 125 SUPERFAMILY SSF55961 2 124 7.56E-16 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 46 176 1.2E-18 T 21-04-2016 IPR000683 Oxidoreductase, N-terminal GO:0016491 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 Gene3D G3DSA:3.40.50.720 40 197 1.2E-42 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 PANTHER PTHR22604:SF122 1 242 9.5E-85 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 PANTHER PTHR22604:SF122 258 449 9.5E-85 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 PANTHER PTHR22604 1 242 9.5E-85 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 PANTHER PTHR22604 258 449 9.5E-85 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 SUPERFAMILY SSF55347 186 214 1.46E-10 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 SUPERFAMILY SSF55347 260 411 1.46E-10 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 Gene3D G3DSA:3.30.360.10 198 440 1.2E-11 T 21-04-2016 SPH21_RS03125 c3dadf183e57f8903f88a7d2e4616b66 471 SUPERFAMILY SSF51735 36 207 1.17E-40 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS10580 45b7f45525d4c11f49630b2b526012cc 303 SUPERFAMILY SSF53850 56 300 5.8E-33 T 21-04-2016 SPH21_RS10580 45b7f45525d4c11f49630b2b526012cc 303 PANTHER PTHR30632 3 301 1.5E-14 T 21-04-2016 SPH21_RS10580 45b7f45525d4c11f49630b2b526012cc 303 Pfam PF13531 Bacterial extracellular solute-binding protein 59 301 9.8E-42 T 21-04-2016 SPH21_RS10580 45b7f45525d4c11f49630b2b526012cc 303 Gene3D G3DSA:3.40.190.10 145 299 4.4E-32 T 21-04-2016 SPH21_RS00775 ee449db1a4074130cc6403a34f59fa38 350 PANTHER PTHR30547:SF5 10 341 6.1E-128 T 21-04-2016 SPH21_RS00775 ee449db1a4074130cc6403a34f59fa38 350 Pfam PF06250 Protein of unknown function (DUF1016) 14 330 1.8E-106 T 21-04-2016 IPR009362 Protein of unknown function DUF1016 SPH21_RS00775 ee449db1a4074130cc6403a34f59fa38 350 PANTHER PTHR30547 10 341 6.1E-128 T 21-04-2016 SPH21_RS03590 8f6e20ccac9d5d000772b6b0ea740397 387 Pfam PF16153 Domain of unknown function (DUF4861) 39 384 2.3E-78 T 21-04-2016 IPR032342 Protein of unknown function DUF4861 SPH21_RS03590 8f6e20ccac9d5d000772b6b0ea740397 387 SUPERFAMILY SSF74650 31 261 4.39E-7 T 21-04-2016 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SPH21_RS25670 cd3b284bf8725b34f1b886903f4370fc 573 TIGRFAM TIGR02289 M3_not_pepF: oligoendopeptidase, M3 family 20 568 2.6E-176 T 21-04-2016 IPR011976 Peptidase M3B, oligoendopeptidase-related clade 2 SPH21_RS25670 cd3b284bf8725b34f1b886903f4370fc 573 Pfam PF01432 Peptidase family M3 171 556 1.5E-44 T 21-04-2016 IPR001567 Peptidase M3A/M3B GO:0004222|GO:0006508 SPH21_RS25670 cd3b284bf8725b34f1b886903f4370fc 573 PANTHER PTHR11804 7 568 2.8E-134 T 21-04-2016 SPH21_RS25670 cd3b284bf8725b34f1b886903f4370fc 573 PANTHER PTHR11804:SF48 7 568 2.8E-134 T 21-04-2016 SPH21_RS25670 cd3b284bf8725b34f1b886903f4370fc 573 Gene3D G3DSA:3.40.390.10 351 398 3.9E-4 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS25670 cd3b284bf8725b34f1b886903f4370fc 573 SUPERFAMILY SSF55486 38 570 4.03E-71 T 21-04-2016 SPH21_RS25670 cd3b284bf8725b34f1b886903f4370fc 573 Gene3D G3DSA:1.10.1370.10 170 276 5.3E-8 T 21-04-2016 IPR024077 Neurolysin/Thimet oligopeptidase, domain 2 SPH21_RS23245 76d7bd20983213648cdde77da9380ae5 241 SMART SM00849 34 232 9.1E-10 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS23245 76d7bd20983213648cdde77da9380ae5 241 PANTHER PTHR23200:SF41 31 241 9.0E-16 T 21-04-2016 SPH21_RS23245 76d7bd20983213648cdde77da9380ae5 241 PANTHER PTHR23200 31 241 9.0E-16 T 21-04-2016 SPH21_RS23245 76d7bd20983213648cdde77da9380ae5 241 Gene3D G3DSA:3.60.15.10 1 234 1.3E-30 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS23245 76d7bd20983213648cdde77da9380ae5 241 SUPERFAMILY SSF56281 1 233 3.14E-24 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS23245 76d7bd20983213648cdde77da9380ae5 241 Pfam PF00753 Metallo-beta-lactamase superfamily 35 197 1.5E-11 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS22125 01502555b99eb4ef555f414bbc7f59f4 128 Pfam PF00072 Response regulator receiver domain 8 114 2.5E-7 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS22125 01502555b99eb4ef555f414bbc7f59f4 128 Gene3D G3DSA:3.40.50.2300 7 122 1.3E-10 T 21-04-2016 SPH21_RS22125 01502555b99eb4ef555f414bbc7f59f4 128 SUPERFAMILY SSF52172 7 124 2.42E-13 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS21430 740103417452e464860e7e611e6711ce 580 Pfam PF12831 FAD dependent oxidoreductase 172 569 9.1E-78 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21430 740103417452e464860e7e611e6711ce 580 PANTHER PTHR10668 129 231 3.4E-14 T 21-04-2016 SPH21_RS21430 740103417452e464860e7e611e6711ce 580 SUPERFAMILY SSF51905 383 392 3.66E-21 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21430 740103417452e464860e7e611e6711ce 580 SUPERFAMILY SSF51905 169 323 3.66E-21 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21430 740103417452e464860e7e611e6711ce 580 SUPERFAMILY SSF51905 494 553 3.66E-21 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21430 740103417452e464860e7e611e6711ce 580 Gene3D G3DSA:3.50.50.60 371 432 1.8E-23 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21430 740103417452e464860e7e611e6711ce 580 Gene3D G3DSA:3.50.50.60 503 575 1.8E-23 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS21430 740103417452e464860e7e611e6711ce 580 Gene3D G3DSA:3.50.50.60 167 310 1.8E-23 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08820 a35b6302a3b3de6e5dbfed05ae8b2fbb 476 PANTHER PTHR30250:SF0 6 476 1.8E-46 T 21-04-2016 SPH21_RS08820 a35b6302a3b3de6e5dbfed05ae8b2fbb 476 Pfam PF01943 Polysaccharide biosynthesis protein 5 268 2.3E-32 T 21-04-2016 IPR002797 Polysaccharide biosynthesis protein GO:0016020 SPH21_RS08820 a35b6302a3b3de6e5dbfed05ae8b2fbb 476 PANTHER PTHR30250 6 476 1.8E-46 T 21-04-2016 SPH21_RS08820 a35b6302a3b3de6e5dbfed05ae8b2fbb 476 Pfam PF14667 Polysaccharide biosynthesis C-terminal domain 325 457 2.5E-17 T 21-04-2016 IPR029303 Polysaccharide biosynthesis protein, C-terminal domain SPH21_RS07275 be3f865db8dab2ffcbfc46b33e8441a6 251 PANTHER PTHR22936 159 238 4.4E-31 T 21-04-2016 IPR002610 Peptidase S54, rhomboid GO:0004252|GO:0006508|GO:0016021 SPH21_RS07275 be3f865db8dab2ffcbfc46b33e8441a6 251 PANTHER PTHR22936 53 114 4.4E-31 T 21-04-2016 IPR002610 Peptidase S54, rhomboid GO:0004252|GO:0006508|GO:0016021 SPH21_RS07275 be3f865db8dab2ffcbfc46b33e8441a6 251 Pfam PF01694 Rhomboid family 52 242 1.2E-30 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS07275 be3f865db8dab2ffcbfc46b33e8441a6 251 SUPERFAMILY SSF144091 11 116 2.75E-41 T 21-04-2016 SPH21_RS07275 be3f865db8dab2ffcbfc46b33e8441a6 251 SUPERFAMILY SSF144091 160 245 2.75E-41 T 21-04-2016 SPH21_RS07275 be3f865db8dab2ffcbfc46b33e8441a6 251 Gene3D G3DSA:1.20.1540.10 160 242 1.1E-40 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS07275 be3f865db8dab2ffcbfc46b33e8441a6 251 Gene3D G3DSA:1.20.1540.10 12 116 1.1E-40 T 21-04-2016 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SPH21_RS23545 13d484211be636e0186767380265b1d6 783 PANTHER PTHR30572 404 783 1.3E-42 T 21-04-2016 SPH21_RS23545 13d484211be636e0186767380265b1d6 783 PANTHER PTHR30572 285 346 1.3E-42 T 21-04-2016 SPH21_RS23545 13d484211be636e0186767380265b1d6 783 Pfam PF12704 MacB-like periplasmic core domain 21 230 8.6E-21 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS23545 13d484211be636e0186767380265b1d6 783 PANTHER PTHR30572:SF4 404 783 1.3E-42 T 21-04-2016 SPH21_RS23545 13d484211be636e0186767380265b1d6 783 PANTHER PTHR30572:SF4 285 346 1.3E-42 T 21-04-2016 SPH21_RS23545 13d484211be636e0186767380265b1d6 783 Pfam PF02687 FtsX-like permease family 281 394 8.4E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS23545 13d484211be636e0186767380265b1d6 783 Pfam PF02687 FtsX-like permease family 663 771 4.1E-10 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS11030 fecdd572a0c92b52687ff68d78b31f1d 405 SUPERFAMILY SSF53822 87 367 6.39E-14 T 21-04-2016 IPR028082 Periplasmic binding protein-like I SPH21_RS11030 fecdd572a0c92b52687ff68d78b31f1d 405 Gene3D G3DSA:3.40.50.2300 105 233 3.1E-6 T 21-04-2016 SPH21_RS11995 4e709a2e92316426bf45c33564f44bb4 206 Gene3D G3DSA:3.10.290.30 1 199 1.8E-32 T 21-04-2016 IPR024047 Protein MM3350-like domain SPH21_RS11995 4e709a2e92316426bf45c33564f44bb4 206 SUPERFAMILY SSF159941 1 175 1.44E-30 T 21-04-2016 IPR024047 Protein MM3350-like domain SPH21_RS11995 4e709a2e92316426bf45c33564f44bb4 206 Pfam PF07929 Plasmid pRiA4b ORF-3-like protein 3 133 5.8E-14 T 21-04-2016 IPR012912 Plasmid pRiA4b, Orf3 SPH21_RS13985 14a74b42e328d3d95ffd166f5987d346 181 Gene3D G3DSA:1.10.1740.10 16 108 3.7E-4 T 21-04-2016 SPH21_RS13985 14a74b42e328d3d95ffd166f5987d346 181 SUPERFAMILY SSF88946 15 86 1.73E-5 T 21-04-2016 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SPH21_RS24225 54c96f1f046c39cdb76533021f056008 272 Pfam PF04397 LytTr DNA-binding domain 182 269 1.4E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS24225 54c96f1f046c39cdb76533021f056008 272 Gene3D G3DSA:2.40.50.40 180 239 3.7E-15 T 21-04-2016 SPH21_RS24225 54c96f1f046c39cdb76533021f056008 272 SMART SM00850 179 271 3.4E-16 T 21-04-2016 IPR007492 LytTR DNA-binding domain GO:0003677 SPH21_RS09255 639c53445ebb2a4b2d7c410703721756 523 Gene3D G3DSA:1.25.40.10 358 453 4.4E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09255 639c53445ebb2a4b2d7c410703721756 523 Gene3D G3DSA:1.25.40.10 189 292 4.4E-35 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09255 639c53445ebb2a4b2d7c410703721756 523 Pfam PF07980 SusD family 251 523 9.3E-49 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09255 639c53445ebb2a4b2d7c410703721756 523 SUPERFAMILY SSF48452 8 523 1.39E-98 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09255 639c53445ebb2a4b2d7c410703721756 523 Pfam PF14322 Starch-binding associating with outer membrane 56 209 2.3E-6 T 21-04-2016 SPH21_RS25405 016a3ddef62568abfd3c382f1012060c 300 PANTHER PTHR40277 11 275 5.1E-18 T 21-04-2016 SPH21_RS25405 016a3ddef62568abfd3c382f1012060c 300 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 13 274 1.5E-31 T 21-04-2016 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SPH21_RS25405 016a3ddef62568abfd3c382f1012060c 300 TIGRFAM TIGR00374 TIGR00374: TIGR00374 family protein 18 176 3.1E-14 T 21-04-2016 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SPH21_RS17815 d2f6f9357587251ff9139eec164c24bf 91 Pfam PF11888 Protein of unknown function (DUF3408) 3 86 4.0E-23 T 21-04-2016 IPR021823 Protein of unknown function DUF3408 SPH21_RS06930 4575130d7035d023c308426a9aeaf3c9 258 Pfam PF11306 Protein of unknown function (DUF3108) 19 246 4.0E-54 T 21-04-2016 IPR021457 Protein of unknown function DUF3108 SPH21_RS19520 077dd461d34f1ce46d861db79fd7bb5f 1759 Pfam PF04357 TamB, inner membrane protein subunit of TAM complex 1201 1644 3.1E-62 T 21-04-2016 IPR007452 Translocation and assembly module TamB SPH21_RS19520 077dd461d34f1ce46d861db79fd7bb5f 1759 Pfam PF04357 TamB, inner membrane protein subunit of TAM complex 1092 1194 4.0E-6 T 21-04-2016 IPR007452 Translocation and assembly module TamB SPH21_RS25935 26d10ca6504d04a17ceed6e22ff990cf 423 PANTHER PTHR16254:SF5 1 387 6.6E-149 T 21-04-2016 SPH21_RS25935 26d10ca6504d04a17ceed6e22ff990cf 423 PANTHER PTHR16254 1 387 6.6E-149 T 21-04-2016 SPH21_RS25935 26d10ca6504d04a17ceed6e22ff990cf 423 Pfam PF00999 Sodium/hydrogen exchanger family 13 380 1.8E-51 T 21-04-2016 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SPH21_RS16495 e494ed21f2dde754339e3d307c58819f 207 SUPERFAMILY SSF47240 47 173 7.3E-5 T 21-04-2016 IPR009078 Ferritin-like superfamily SPH21_RS11130 4944ebd432fa560abba1fae479b07287 289 PIRSF PIRSF006483 1 286 5.1E-72 T 21-04-2016 IPR003740 Uncharacterised membrane protein YitT SPH21_RS11130 4944ebd432fa560abba1fae479b07287 289 PANTHER PTHR33545 8 288 2.8E-66 T 21-04-2016 SPH21_RS11130 4944ebd432fa560abba1fae479b07287 289 Pfam PF10035 Uncharacterized protein conserved in bacteria (DUF2179) 219 279 1.6E-16 T 21-04-2016 IPR019264 Domain of unknown function DUF2179 SPH21_RS11130 4944ebd432fa560abba1fae479b07287 289 Pfam PF02588 Uncharacterised 5xTM membrane BCR, YitT family COG1284 11 213 7.5E-50 T 21-04-2016 IPR003740 Uncharacterised membrane protein YitT SPH21_RS25520 2cc83d8f5d15b6eb14f4641e8f360608 60 Pfam PF14128 Domain of unknown function (DUF4295) 2 47 9.2E-24 T 21-04-2016 IPR025379 Protein of unknown function DUF4295 SPH21_RS22995 1dd7f0f9ec959a4eedc53de25458b498 247 Pfam PF16248 Domain of unknown function (DUF4905) 18 98 4.4E-28 T 21-04-2016 IPR032595 Protein of unknown function DUF4905 SPH21_RS00280 6bf115aeae9c6faffe7a70d0896f6cd8 397 PANTHER PTHR30474 11 384 2.7E-94 T 21-04-2016 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SPH21_RS00280 6bf115aeae9c6faffe7a70d0896f6cd8 397 Pfam PF01098 Cell cycle protein 13 366 1.5E-74 T 21-04-2016 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SPH21_RS00280 6bf115aeae9c6faffe7a70d0896f6cd8 397 PANTHER PTHR30474:SF2 11 384 2.7E-94 T 21-04-2016 SPH21_RS07475 1cd96101038f787edac8ec263074b800 287 Pfam PF03755 YicC-like family, N-terminal region 1 151 6.6E-37 T 21-04-2016 IPR013527 YicC-like, N-terminal SPH21_RS07475 1cd96101038f787edac8ec263074b800 287 TIGRFAM TIGR00255 TIGR00255: TIGR00255 family protein 1 286 4.7E-62 T 21-04-2016 IPR005229 Conserved hypothetical protein CHP00255 SPH21_RS07475 1cd96101038f787edac8ec263074b800 287 PANTHER PTHR30636 1 287 6.5E-77 T 21-04-2016 SPH21_RS07475 1cd96101038f787edac8ec263074b800 287 Pfam PF08340 Domain of unknown function (DUF1732) 203 286 1.6E-31 T 21-04-2016 IPR013551 Domain of unknown function DUF1732 SPH21_RS22160 67c9b9e8ffa227052a739e18f5ca4e0f 246 PANTHER PTHR11351:SF34 1 238 4.4E-40 T 21-04-2016 SPH21_RS22160 67c9b9e8ffa227052a739e18f5ca4e0f 246 PANTHER PTHR11351 1 238 4.4E-40 T 21-04-2016 SPH21_RS22160 67c9b9e8ffa227052a739e18f5ca4e0f 246 Pfam PF00487 Fatty acid desaturase 4 228 1.6E-16 T 21-04-2016 IPR005804 Fatty acid desaturase domain GO:0006629 SPH21_RS23220 c73eec6de4ddc27176f8c6bc0e78530f 696 PANTHER PTHR31151 96 264 1.4E-69 T 21-04-2016 SPH21_RS23220 c73eec6de4ddc27176f8c6bc0e78530f 696 PANTHER PTHR31151 288 696 1.4E-69 T 21-04-2016 SPH21_RS23220 c73eec6de4ddc27176f8c6bc0e78530f 696 SUPERFAMILY SSF48208 78 126 3.01E-25 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS23220 c73eec6de4ddc27176f8c6bc0e78530f 696 SUPERFAMILY SSF48208 153 388 3.01E-25 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS23220 c73eec6de4ddc27176f8c6bc0e78530f 696 Gene3D G3DSA:1.50.10.10 110 239 1.4E-5 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS23220 c73eec6de4ddc27176f8c6bc0e78530f 696 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 96 577 2.7E-68 T 21-04-2016 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 PANTHER PTHR23091 11 135 1.7E-14 T 21-04-2016 SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 SUPERFAMILY SSF55729 34 144 1.46E-21 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 Gene3D G3DSA:3.40.630.30 26 160 1.7E-25 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 PRINTS PR01754 Streptothricin acetyltransferase signature 81 96 3.3E-15 T 21-04-2016 IPR008125 Streptothricin acetyltransferase SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 PRINTS PR01754 Streptothricin acetyltransferase signature 105 120 3.3E-15 T 21-04-2016 IPR008125 Streptothricin acetyltransferase SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 PRINTS PR01754 Streptothricin acetyltransferase signature 149 162 3.3E-15 T 21-04-2016 IPR008125 Streptothricin acetyltransferase SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 PRINTS PR01754 Streptothricin acetyltransferase signature 126 142 3.3E-15 T 21-04-2016 IPR008125 Streptothricin acetyltransferase SPH21_RS04645 a46d2f82753decbac5d2f88ecd9263d4 163 Pfam PF00583 Acetyltransferase (GNAT) family 63 134 1.1E-14 T 21-04-2016 IPR000182 GNAT domain GO:0008080 SPH21_RS10610 67fe02bdcfc32a28a19064ae44bc2e0b 195 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 49 71 - T 21-04-2016 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SPH21_RS10610 67fe02bdcfc32a28a19064ae44bc2e0b 195 Pfam PF01066 CDP-alcohol phosphatidyltransferase 9 71 1.0E-12 T 21-04-2016 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SPH21_RS09000 3ac9e6f390e7555ec108da252ccfd3ef 469 Pfam PF01943 Polysaccharide biosynthesis protein 9 278 7.0E-9 T 21-04-2016 IPR002797 Polysaccharide biosynthesis protein GO:0016020 SPH21_RS06925 ebb0fa6157d4848ab079750ba0f352d6 189 Pfam PF11307 Protein of unknown function (DUF3109) 1 181 8.4E-80 T 21-04-2016 IPR021458 Protein of unknown function DUF3109 SPH21_RS25540 a57fafb4f05b050ca915f79a8d1534a8 117 Pfam PF04237 YjbR 11 103 1.0E-28 T 21-04-2016 IPR007351 Uncharacterised protein YjbR SPH21_RS25540 a57fafb4f05b050ca915f79a8d1534a8 117 SUPERFAMILY SSF142906 1 116 1.01E-43 T 21-04-2016 SPH21_RS25540 a57fafb4f05b050ca915f79a8d1534a8 117 PANTHER PTHR35145 1 116 6.7E-37 T 21-04-2016 SPH21_RS14000 7679c62af9e05b55e8dc01f125afe3f4 153 Pfam PF13441 YMGG-like Gly-zipper 99 143 3.8E-11 T 21-04-2016 IPR027367 YMGG-like Gly-zipper SPH21_RS21125 252335f64c576fe75c03f5a98ef284ca 274 SMART SM00342 173 261 0.0038 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21125 252335f64c576fe75c03f5a98ef284ca 274 Pfam PF12833 Helix-turn-helix domain 180 261 8.5E-8 T 21-04-2016 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SPH21_RS21125 252335f64c576fe75c03f5a98ef284ca 274 Gene3D G3DSA:1.10.10.60 210 262 8.0E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS14180 aee92e98caf763adceec54de35891a6b 429 SUPERFAMILY SSF51604 180 353 2.89E-15 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS14180 aee92e98caf763adceec54de35891a6b 429 Gene3D G3DSA:3.20.20.120 162 374 3.3E-21 T 21-04-2016 IPR029065 Enolase C-terminal domain-like SPH21_RS22820 7ea4ab85bbd2cf74abda87394f39d922 275 Pfam PF06067 Domain of unknown function (DUF932) 93 259 2.7E-53 T 21-04-2016 IPR026325 Protein of unknown function DUF932 SPH21_RS22820 7ea4ab85bbd2cf74abda87394f39d922 275 TIGRFAM TIGR03299 LGT_TIGR03299: phage/plasmid-like protein TIGR03299 17 249 1.1E-58 T 21-04-2016 IPR017686 Phage/plasmid-like protein SPH21_RS20930 466cc87adb998a29713e38af7b0c5b1f 158 Pfam PF14358 Domain of unknown function (DUF4405) 8 58 6.1E-8 T 21-04-2016 IPR025517 Domain of unknown function DUF4405 SPH21_RS20680 814a3af37ceacf542d943d9bba12a325 179 Pfam PF07853 Protein of unknown function (DUF1648) 31 75 5.2E-9 T 21-04-2016 IPR012867 Domain of unknown function DUF1648 SPH21_RS18640 9224f12a6e356c7c5e84435e2b1a90c6 419 Pfam PF13372 Alginate export 20 382 5.7E-16 T 21-04-2016 IPR025388 Alginate export domain UniPathway: UPA00286 SPH21_RS09835 b007c5fddcd1e8154b9c38df69a50a8a 858 Gene3D G3DSA:1.50.10.10 518 601 2.6E-7 T 21-04-2016 IPR012341 Six-hairpin glycosidase GO:0003824 SPH21_RS09835 b007c5fddcd1e8154b9c38df69a50a8a 858 SUPERFAMILY SSF48208 465 714 1.42E-12 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS02930 7a7c7181af70dea93d19acc7cc5cb901 178 SUPERFAMILY SSF52833 44 164 9.47E-6 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS02930 7a7c7181af70dea93d19acc7cc5cb901 178 Gene3D G3DSA:3.40.30.10 23 176 1.2E-6 T 21-04-2016 IPR012336 Thioredoxin-like fold SPH21_RS03915 994c6f1fffb8dc418c507902ec8cc253 292 Gene3D G3DSA:2.60.120.200 61 272 2.7E-21 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS03915 994c6f1fffb8dc418c507902ec8cc253 292 Pfam PF00722 Glycosyl hydrolases family 16 102 264 5.2E-6 T 21-04-2016 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 SPH21_RS03915 994c6f1fffb8dc418c507902ec8cc253 292 SUPERFAMILY SSF49899 61 269 5.47E-21 T 21-04-2016 IPR013320 Concanavalin A-like lectin/glucanase domain SPH21_RS02125 a0433d33a8097196f1d54d98145d6feb 580 SUPERFAMILY SSF48452 14 490 2.66E-98 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02125 a0433d33a8097196f1d54d98145d6feb 580 SUPERFAMILY SSF48452 545 577 2.66E-98 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02125 a0433d33a8097196f1d54d98145d6feb 580 Pfam PF07980 SusD family 292 577 1.4E-42 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS02125 a0433d33a8097196f1d54d98145d6feb 580 Gene3D G3DSA:1.25.40.10 186 303 6.7E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02125 a0433d33a8097196f1d54d98145d6feb 580 Gene3D G3DSA:1.25.40.10 358 463 6.7E-32 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02125 a0433d33a8097196f1d54d98145d6feb 580 Pfam PF14322 Starch-binding associating with outer membrane 92 202 1.1E-11 T 21-04-2016 SPH21_RS08940 979a4f633ae404e07f8517efa83c86f4 564 Pfam PF14052 Capsule assembly protein Wzi 206 517 1.3E-14 T 21-04-2016 IPR026950 Capsule assembly protein Wzi SPH21_RS13195 3f9865edcb571cf3b96fead0fa41e210 215 PANTHER PTHR10509 37 200 1.1E-33 T 21-04-2016 SPH21_RS13195 3f9865edcb571cf3b96fead0fa41e210 215 SUPERFAMILY SSF53335 48 213 7.96E-31 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS13195 3f9865edcb571cf3b96fead0fa41e210 215 Pfam PF01596 O-methyltransferase 29 178 3.8E-24 T 21-04-2016 IPR002935 O-methyltransferase, family 3 GO:0008171 SPH21_RS13195 3f9865edcb571cf3b96fead0fa41e210 215 Gene3D G3DSA:3.40.50.150 23 214 1.9E-43 T 21-04-2016 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SPH21_RS21370 b320ca2682a2732e9e08aca78e6f6ae6 115 PANTHER PTHR35174 3 111 5.7E-15 T 21-04-2016 SPH21_RS21370 b320ca2682a2732e9e08aca78e6f6ae6 115 Pfam PF03795 YCII-related domain 17 109 5.0E-12 T 21-04-2016 IPR005545 YCII-related SPH21_RS21370 b320ca2682a2732e9e08aca78e6f6ae6 115 Gene3D G3DSA:3.30.70.1060 1 110 1.8E-22 T 21-04-2016 SPH21_RS21370 b320ca2682a2732e9e08aca78e6f6ae6 115 SUPERFAMILY SSF54909 22 109 1.58E-18 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS16565 c272d0c43d125903eff8a47080a5e0e0 279 SMART SM00316 145 207 0.0066 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS16565 c272d0c43d125903eff8a47080a5e0e0 279 SMART SM00316 70 132 33.0 T 21-04-2016 IPR022967 RNA-binding domain, S1 SPH21_RS16565 c272d0c43d125903eff8a47080a5e0e0 279 Pfam PF13509 S1 domain 4 65 8.8E-10 T 21-04-2016 SPH21_RS16565 c272d0c43d125903eff8a47080a5e0e0 279 PANTHER PTHR37296 1 279 1.4E-77 T 21-04-2016 SPH21_RS16565 c272d0c43d125903eff8a47080a5e0e0 279 PIRSF PIRSF012524 1 278 3.9E-66 T 21-04-2016 IPR014464 Conserved virulence factor B SPH21_RS03525 480749486d65f0acd185a7c8cb68b547 505 PANTHER PTHR31901 3 500 2.1E-66 T 21-04-2016 IPR004993 GH3 family KEGG: 00220+6.3.2.-|KEGG: 00261+6.3.2.-|KEGG: 00380+6.3.2.- SPH21_RS03525 480749486d65f0acd185a7c8cb68b547 505 PANTHER PTHR31901:SF5 3 500 2.1E-66 T 21-04-2016 SPH21_RS03525 480749486d65f0acd185a7c8cb68b547 505 Pfam PF03321 GH3 auxin-responsive promoter 19 493 4.6E-113 T 21-04-2016 IPR004993 GH3 family KEGG: 00220+6.3.2.-|KEGG: 00261+6.3.2.-|KEGG: 00380+6.3.2.- SPH21_RS04805 7e07780f5a3a9aeb3430f0b2eef6be6f 521 PANTHER PTHR11819 7 438 2.3E-91 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS04805 7e07780f5a3a9aeb3430f0b2eef6be6f 521 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 38 438 7.1E-62 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS04805 7e07780f5a3a9aeb3430f0b2eef6be6f 521 Pfam PF00474 Sodium:solute symporter family 38 432 5.5E-36 T 21-04-2016 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SPH21_RS17825 fb7707529c26adaf42135eeb6c4018ae 255 PANTHER PTHR13696 5 239 6.6E-22 T 21-04-2016 SPH21_RS17825 fb7707529c26adaf42135eeb6c4018ae 255 Gene3D G3DSA:3.40.50.300 5 219 2.2E-24 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17825 fb7707529c26adaf42135eeb6c4018ae 255 SUPERFAMILY SSF52540 7 215 1.19E-20 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17825 fb7707529c26adaf42135eeb6c4018ae 255 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 10 198 3.7E-14 T 21-04-2016 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain SPH21_RS17825 fb7707529c26adaf42135eeb6c4018ae 255 PANTHER PTHR13696:SF52 5 239 6.6E-22 T 21-04-2016 SPH21_RS13695 b7c1a58ff0e464f1bbd8dc4c261b569f 543 Pfam PF16400 Domain of unknown function (DUF5008) 21 122 1.0E-40 T 21-04-2016 IPR032175 Domain of unknown function DUF5008 SPH21_RS13695 b7c1a58ff0e464f1bbd8dc4c261b569f 543 Gene3D G3DSA:2.60.40.10 54 114 3.4E-4 T 21-04-2016 IPR013783 Immunoglobulin-like fold SPH21_RS13695 b7c1a58ff0e464f1bbd8dc4c261b569f 543 Pfam PF17164 Domain of unknown function (DUF5122) beta-propeller 461 491 2.0E-4 T 21-04-2016 IPR013431 Delta-60 repeat SPH21_RS13695 b7c1a58ff0e464f1bbd8dc4c261b569f 543 Pfam PF17164 Domain of unknown function (DUF5122) beta-propeller 359 391 6.8E-9 T 21-04-2016 IPR013431 Delta-60 repeat SPH21_RS13695 b7c1a58ff0e464f1bbd8dc4c261b569f 543 Pfam PF17164 Domain of unknown function (DUF5122) beta-propeller 413 444 4.3E-5 T 21-04-2016 IPR013431 Delta-60 repeat SPH21_RS09940 9f2fdba14601f25a3a226e236f94c717 373 Pfam PF01757 Acyltransferase family 9 320 1.3E-22 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS09940 9f2fdba14601f25a3a226e236f94c717 373 PANTHER PTHR23028 6 354 9.4E-23 T 21-04-2016 SPH21_RS18965 b137c1a871ea17a1ad5e8afdb26ac647 248 PIRSF PIRSF008292 5 242 1.6E-67 T 21-04-2016 IPR016538 Uncharacterised conserved protein UCP008292 SPH21_RS18965 b137c1a871ea17a1ad5e8afdb26ac647 248 PANTHER PTHR31302 8 134 3.6E-14 T 21-04-2016 SPH21_RS18965 b137c1a871ea17a1ad5e8afdb26ac647 248 PANTHER PTHR31302 190 225 3.6E-14 T 21-04-2016 SPH21_RS18965 b137c1a871ea17a1ad5e8afdb26ac647 248 PANTHER PTHR31302 156 174 3.6E-14 T 21-04-2016 SPH21_RS18965 b137c1a871ea17a1ad5e8afdb26ac647 248 SUPERFAMILY SSF56300 9 239 2.78E-29 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS18965 b137c1a871ea17a1ad5e8afdb26ac647 248 Gene3D G3DSA:3.60.21.10 9 245 1.8E-25 T 21-04-2016 IPR029052 Metallo-dependent phosphatase-like SPH21_RS18965 b137c1a871ea17a1ad5e8afdb26ac647 248 Pfam PF00149 Calcineurin-like phosphoesterase 8 210 3.7E-14 T 21-04-2016 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SPH21_RS12320 92df85c5d509447ace2d2e0af24f5731 121 Gene3D G3DSA:1.10.10.10 5 115 5.0E-39 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS12320 92df85c5d509447ace2d2e0af24f5731 121 Pfam PF01638 HxlR-like helix-turn-helix 29 114 2.1E-33 T 21-04-2016 IPR002577 Helix-turn-helix, HxlR type SPH21_RS12320 92df85c5d509447ace2d2e0af24f5731 121 PANTHER PTHR33204 8 114 1.3E-37 T 21-04-2016 SPH21_RS12320 92df85c5d509447ace2d2e0af24f5731 121 SUPERFAMILY SSF46785 19 114 5.46E-29 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23160 a91986a935437e65c822796c7dd24e86 389 PANTHER PTHR30273 20 110 2.4E-70 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS23160 a91986a935437e65c822796c7dd24e86 389 PANTHER PTHR30273 176 387 2.4E-70 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS23160 a91986a935437e65c822796c7dd24e86 389 Pfam PF04773 FecR protein 174 269 8.4E-15 T 21-04-2016 IPR006860 FecR protein SPH21_RS23160 a91986a935437e65c822796c7dd24e86 389 PANTHER PTHR30273:SF2 20 110 2.4E-70 T 21-04-2016 SPH21_RS23160 a91986a935437e65c822796c7dd24e86 389 PANTHER PTHR30273:SF2 176 387 2.4E-70 T 21-04-2016 SPH21_RS23160 a91986a935437e65c822796c7dd24e86 389 Pfam PF16344 Domain of unknown function (DUF4974) 282 380 6.9E-26 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS17405 98aac6c4b1d97458ad840d63d8eeb809 972 Pfam PF08800 VirE N-terminal domain 53 170 7.7E-23 T 21-04-2016 IPR014907 Virulence-protein E, N-terminal SPH21_RS17405 98aac6c4b1d97458ad840d63d8eeb809 972 Pfam PF06048 Domain of unknown function (DUF927) 422 647 9.1E-7 T 21-04-2016 IPR009270 Domain of unknown function DUF927 SPH21_RS05995 d2b8509885fddd7c918884c3e42f158c 190 SUPERFAMILY SSF82057 121 189 5.95E-21 T 21-04-2016 SPH21_RS05995 d2b8509885fddd7c918884c3e42f158c 190 Pfam PF03831 PhnA domain 123 190 4.1E-26 T 21-04-2016 IPR013988 PhnA protein, C-terminal SPH21_RS05995 d2b8509885fddd7c918884c3e42f158c 190 Gene3D G3DSA:2.30.30.40 122 189 2.5E-24 T 21-04-2016 SPH21_RS05995 d2b8509885fddd7c918884c3e42f158c 190 PANTHER PTHR30305:SF2 1 190 3.7E-45 T 21-04-2016 SPH21_RS05995 d2b8509885fddd7c918884c3e42f158c 190 PANTHER PTHR30305 1 190 3.7E-45 T 21-04-2016 SPH21_RS08195 14d471a8ef1dc96d7d4c8f3b566cc576 567 SUPERFAMILY SSF51905 42 221 1.58E-18 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08195 14d471a8ef1dc96d7d4c8f3b566cc576 567 SUPERFAMILY SSF51905 377 403 1.58E-18 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08195 14d471a8ef1dc96d7d4c8f3b566cc576 567 SUPERFAMILY SSF51905 270 276 1.58E-18 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08195 14d471a8ef1dc96d7d4c8f3b566cc576 567 Gene3D G3DSA:3.50.50.60 371 418 4.7E-19 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08195 14d471a8ef1dc96d7d4c8f3b566cc576 567 Gene3D G3DSA:3.50.50.60 35 275 4.7E-19 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS08195 14d471a8ef1dc96d7d4c8f3b566cc576 567 Pfam PF12831 FAD dependent oxidoreductase 42 550 2.5E-98 T 21-04-2016 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SPH21_RS12040 dacd1f7bcf60a86621e001ddd3b48cbc 282 PANTHER PTHR22916 166 213 1.5E-32 T 21-04-2016 SPH21_RS12040 dacd1f7bcf60a86621e001ddd3b48cbc 282 PANTHER PTHR22916 9 145 1.5E-32 T 21-04-2016 SPH21_RS12040 dacd1f7bcf60a86621e001ddd3b48cbc 282 PANTHER PTHR22916:SF31 166 213 1.5E-32 T 21-04-2016 SPH21_RS12040 dacd1f7bcf60a86621e001ddd3b48cbc 282 PANTHER PTHR22916:SF31 9 145 1.5E-32 T 21-04-2016 SPH21_RS12040 dacd1f7bcf60a86621e001ddd3b48cbc 282 SUPERFAMILY SSF53448 4 236 6.38E-39 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS12040 dacd1f7bcf60a86621e001ddd3b48cbc 282 Pfam PF00535 Glycosyl transferase family 2 9 183 2.3E-17 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS12040 dacd1f7bcf60a86621e001ddd3b48cbc 282 Gene3D G3DSA:3.90.550.10 3 264 1.2E-49 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS10955 066612979dbf551a64379ac896ee2290 233 Pfam PF01618 MotA/TolQ/ExbB proton channel family 98 218 1.8E-22 T 21-04-2016 IPR002898 MotA/TolQ/ExbB proton channel GO:0006810|GO:0008565|GO:0016020 SPH21_RS10955 066612979dbf551a64379ac896ee2290 233 PANTHER PTHR30625:SF0 22 233 1.7E-36 T 21-04-2016 SPH21_RS10955 066612979dbf551a64379ac896ee2290 233 PANTHER PTHR30625 22 233 1.7E-36 T 21-04-2016 SPH21_RS05975 2672327037e34147acc44d80d7372074 229 PANTHER PTHR30489:SF14 1 205 2.3E-12 T 21-04-2016 SPH21_RS05975 2672327037e34147acc44d80d7372074 229 PANTHER PTHR30489 1 205 2.3E-12 T 21-04-2016 SPH21_RS05975 2672327037e34147acc44d80d7372074 229 Pfam PF12704 MacB-like periplasmic core domain 20 201 1.9E-18 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS03495 c9821a35b2ce79c1a18ebc66995182b8 313 Pfam PF01944 Stage II sporulation protein M 100 277 6.1E-37 T 21-04-2016 IPR002798 Stage II sporulation protein M-like SPH21_RS03495 c9821a35b2ce79c1a18ebc66995182b8 313 PANTHER PTHR35337 26 305 4.9E-37 T 21-04-2016 SPH21_RS19880 625eb4b0ba0e8972eeddde0092f51309 171 PANTHER PTHR37833 61 170 1.9E-19 T 21-04-2016 SPH21_RS19880 625eb4b0ba0e8972eeddde0092f51309 171 PANTHER PTHR37833:SF1 61 170 1.9E-19 T 21-04-2016 SPH21_RS19880 625eb4b0ba0e8972eeddde0092f51309 171 Gene3D G3DSA:2.60.40.360 68 170 4.9E-28 T 21-04-2016 IPR008962 PapD-like SPH21_RS19880 625eb4b0ba0e8972eeddde0092f51309 171 Pfam PF07610 Protein of unknown function (DUF1573) 95 138 1.2E-21 T 21-04-2016 IPR011467 Protein of unknown function DUF1573 SPH21_RS19900 f5744aec115c8b390ab5e50884d6d3ba 178 SUPERFAMILY SSF48452 15 156 1.18E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19900 f5744aec115c8b390ab5e50884d6d3ba 178 Gene3D G3DSA:1.25.40.10 51 153 1.8E-4 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS10585 0cbeb07a250985a4e0fb7cbd97d5a62a 157 Gene3D G3DSA:3.40.1260.10 44 157 2.4E-29 T 21-04-2016 IPR027396 DsrEFH-like SPH21_RS10585 0cbeb07a250985a4e0fb7cbd97d5a62a 157 SUPERFAMILY SSF75169 45 157 6.18E-19 T 21-04-2016 IPR027396 DsrEFH-like SPH21_RS10585 0cbeb07a250985a4e0fb7cbd97d5a62a 157 Pfam PF02635 DsrE/DsrF-like family 57 157 2.4E-6 T 21-04-2016 IPR003787 Sulphur relay, DsrE/F-like protein SPH21_RS18080 9a1c45bb5924a6d726eba649514fe24b 261 PANTHER PTHR11941 15 226 1.7E-35 T 21-04-2016 SPH21_RS18080 9a1c45bb5924a6d726eba649514fe24b 261 Pfam PF00378 Enoyl-CoA hydratase/isomerase 16 251 2.6E-31 T 21-04-2016 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SPH21_RS18080 9a1c45bb5924a6d726eba649514fe24b 261 Gene3D G3DSA:3.90.226.10 8 254 2.4E-42 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS18080 9a1c45bb5924a6d726eba649514fe24b 261 SUPERFAMILY SSF52096 8 252 7.97E-44 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS00840 f6967962b9c4b015d446068d199d6465 140 SUPERFAMILY SSF54427 9 131 1.78E-14 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS00840 f6967962b9c4b015d446068d199d6465 140 Gene3D G3DSA:3.10.450.50 9 120 1.8E-11 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS17725 2b47b5dc08648a222575abf23962ebc1 147 SUPERFAMILY SSF52172 10 127 4.55E-15 T 21-04-2016 IPR011006 CheY-like superfamily SPH21_RS17725 2b47b5dc08648a222575abf23962ebc1 147 Gene3D G3DSA:3.40.50.2300 9 127 1.2E-15 T 21-04-2016 SPH21_RS17725 2b47b5dc08648a222575abf23962ebc1 147 SMART SM00448 11 119 4.2E-4 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS17725 2b47b5dc08648a222575abf23962ebc1 147 Pfam PF00072 Response regulator receiver domain 13 119 5.1E-11 T 21-04-2016 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 Reactome: REACT_14797 SPH21_RS01330 5996468a839741af673175f5b036c26b 428 Pfam PF03432 Relaxase/Mobilisation nuclease domain 61 160 9.7E-10 T 21-04-2016 IPR005094 Endonuclease relaxase, MobA/VirD2 SPH21_RS07975 60eb05038bdfbfb04f096ab1c0b563f1 116 PANTHER PTHR37309 1 116 1.6E-19 T 21-04-2016 SPH21_RS07975 60eb05038bdfbfb04f096ab1c0b563f1 116 PANTHER PTHR37309:SF1 1 116 1.6E-19 T 21-04-2016 SPH21_RS07975 60eb05038bdfbfb04f096ab1c0b563f1 116 Pfam PF04020 Mycobacterial 4 TMS phage holin, superfamily IV 1 105 3.6E-25 T 21-04-2016 IPR007165 Mycobacterial 4 TMS phage holin, superfamily IV SPH21_RS08275 0d3b94c39eaa3b87c4789228824c5489 178 Pfam PF06271 RDD family 42 168 4.7E-24 T 21-04-2016 IPR010432 RDD SPH21_RS18620 eb5041f5b56af988aa506e9c6dcf992a 212 Pfam PF12804 MobA-like NTP transferase domain 9 170 8.5E-33 T 21-04-2016 IPR025877 MobA-like NTP transferase SPH21_RS18620 eb5041f5b56af988aa506e9c6dcf992a 212 SUPERFAMILY SSF53448 8 195 2.17E-23 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS18620 eb5041f5b56af988aa506e9c6dcf992a 212 PANTHER PTHR19136 9 195 5.2E-22 T 21-04-2016 SPH21_RS18620 eb5041f5b56af988aa506e9c6dcf992a 212 Gene3D G3DSA:3.90.550.10 7 195 4.3E-26 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS08715 ad3f7b8eba073c34e36cff893fc7437d 255 Pfam PF06439 Domain of Unknown Function (DUF1080) 51 253 5.6E-40 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS08715 ad3f7b8eba073c34e36cff893fc7437d 255 PANTHER PTHR33546:SF1 100 255 9.4E-16 T 21-04-2016 SPH21_RS08715 ad3f7b8eba073c34e36cff893fc7437d 255 PANTHER PTHR33546 100 255 9.4E-16 T 21-04-2016 SPH21_RS22345 dfe6e0d40f8b5e3c9ffb75f5d3eb14fb 201 Gene3D G3DSA:2.60.120.10 13 167 2.1E-30 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS22345 dfe6e0d40f8b5e3c9ffb75f5d3eb14fb 201 PANTHER PTHR24567 25 201 4.0E-24 T 21-04-2016 SPH21_RS22345 dfe6e0d40f8b5e3c9ffb75f5d3eb14fb 201 SUPERFAMILY SSF51206 25 154 1.09E-19 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS22345 dfe6e0d40f8b5e3c9ffb75f5d3eb14fb 201 PANTHER PTHR24567:SF33 25 201 4.0E-24 T 21-04-2016 SPH21_RS22345 dfe6e0d40f8b5e3c9ffb75f5d3eb14fb 201 Pfam PF00027 Cyclic nucleotide-binding domain 42 126 2.6E-9 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS25705 e0589202e9a9553dcfec30446998d74e 212 Pfam PF14470 Bacterial PH domain 27 123 6.9E-18 T 21-04-2016 SPH21_RS25705 e0589202e9a9553dcfec30446998d74e 212 Pfam PF09851 Short C-terminal domain 183 209 1.8E-6 T 21-04-2016 IPR018649 SHOCT domain SPH21_RS24455 79e730b35ba87f440cf4830002e5cb6c 488 SUPERFAMILY SSF54001 73 228 6.21E-7 T 21-04-2016 SPH21_RS24455 79e730b35ba87f440cf4830002e5cb6c 488 PANTHER PTHR35532 64 402 4.9E-13 T 21-04-2016 SPH21_RS24455 79e730b35ba87f440cf4830002e5cb6c 488 PANTHER PTHR35532:SF3 64 402 4.9E-13 T 21-04-2016 SPH21_RS07060 b2a18b3969941aca567dd88bb0f45e65 809 SUPERFAMILY SSF48452 173 269 6.07E-5 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS03395 29d813b1a0ef2a4f12f70c006775aef5 469 Gene3D G3DSA:3.90.226.10 227 329 7.3E-29 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS03395 29d813b1a0ef2a4f12f70c006775aef5 469 Gene3D G3DSA:3.90.226.10 362 454 7.3E-29 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS03395 29d813b1a0ef2a4f12f70c006775aef5 469 Pfam PF03572 Peptidase family S41 239 447 6.1E-20 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS03395 29d813b1a0ef2a4f12f70c006775aef5 469 SMART SM00245 228 450 0.0064 T 21-04-2016 IPR005151 Tail specific protease GO:0006508|GO:0008236 SPH21_RS03395 29d813b1a0ef2a4f12f70c006775aef5 469 SUPERFAMILY SSF52096 233 321 1.38E-28 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS03395 29d813b1a0ef2a4f12f70c006775aef5 469 SUPERFAMILY SSF52096 55 131 1.38E-28 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS03395 29d813b1a0ef2a4f12f70c006775aef5 469 SUPERFAMILY SSF52096 364 454 1.38E-28 T 21-04-2016 IPR029045 ClpP/crotonase-like domain SPH21_RS04935 c81e3f8b992c06c7462f102fb146e853 319 PANTHER PTHR12035:SF58 53 132 1.4E-20 T 21-04-2016 SPH21_RS04935 c81e3f8b992c06c7462f102fb146e853 319 PANTHER PTHR12035:SF58 160 293 1.4E-20 T 21-04-2016 SPH21_RS04935 c81e3f8b992c06c7462f102fb146e853 319 SUPERFAMILY SSF55486 166 294 2.64E-5 T 21-04-2016 SPH21_RS04935 c81e3f8b992c06c7462f102fb146e853 319 Gene3D G3DSA:3.40.390.10 197 293 5.6E-7 T 21-04-2016 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SPH21_RS04935 c81e3f8b992c06c7462f102fb146e853 319 PANTHER PTHR12035 53 132 1.4E-20 T 21-04-2016 SPH21_RS04935 c81e3f8b992c06c7462f102fb146e853 319 PANTHER PTHR12035 160 293 1.4E-20 T 21-04-2016 SPH21_RS10215 34bc6e84a6236774bfacae780ea1ffb5 358 Gene3D G3DSA:3.40.50.2000 165 280 7.9E-7 T 21-04-2016 SPH21_RS10215 34bc6e84a6236774bfacae780ea1ffb5 358 SUPERFAMILY SSF53756 67 348 1.41E-26 T 21-04-2016 SPH21_RS10215 34bc6e84a6236774bfacae780ea1ffb5 358 Pfam PF00534 Glycosyl transferases group 1 162 282 2.5E-8 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS10755 1f56faa226e6281dd68c161db1d8610a 120 Pfam PF11964 SpoIIAA-like 8 114 1.1E-14 T 21-04-2016 IPR021866 SpoIIAA-like SPH21_RS10755 1f56faa226e6281dd68c161db1d8610a 120 SUPERFAMILY SSF52091 2 115 4.71E-25 T 21-04-2016 IPR002645 STAS domain SPH21_RS10755 1f56faa226e6281dd68c161db1d8610a 120 Gene3D G3DSA:3.40.50.10600 2 115 1.7E-27 T 21-04-2016 IPR021866 SpoIIAA-like SPH21_RS17840 378ad619545aeb181b88300681fd2b8d 432 Pfam PF03432 Relaxase/Mobilisation nuclease domain 44 160 7.1E-14 T 21-04-2016 IPR005094 Endonuclease relaxase, MobA/VirD2 SPH21_RS00180 d8670ca39d98c137a585efdf37c181b7 211 Gene3D G3DSA:1.20.58.60 82 126 7.6E-4 T 21-04-2016 SPH21_RS00180 d8670ca39d98c137a585efdf37c181b7 211 Gene3D G3DSA:1.20.58.60 174 199 7.6E-4 T 21-04-2016 SPH21_RS00180 d8670ca39d98c137a585efdf37c181b7 211 SUPERFAMILY SSF58100 48 164 4.71E-6 T 21-04-2016 SPH21_RS24990 7ed21b6c8d20e6d2e34ae8c927ed7e20 88 Pfam PF14606 GDSL-like Lipase/Acylhydrolase family 4 82 1.8E-9 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS09125 c5083213fa857866e88173a813a2ac67 99 Pfam PF13470 PIN domain 1 74 3.2E-7 T 21-04-2016 IPR002716 PIN domain SPH21_RS20040 f1f028ceb8fa2abb029c007d7cae4044 276 Pfam PF00135 Carboxylesterase family 38 189 6.7E-16 T 21-04-2016 IPR002018 Carboxylesterase, type B SPH21_RS20040 f1f028ceb8fa2abb029c007d7cae4044 276 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 123 138 - T 21-04-2016 IPR019826 Carboxylesterase type B, active site SPH21_RS20040 f1f028ceb8fa2abb029c007d7cae4044 276 SUPERFAMILY SSF53474 41 272 1.41E-35 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS20040 f1f028ceb8fa2abb029c007d7cae4044 276 PANTHER PTHR23024:SF156 42 276 9.1E-30 T 21-04-2016 SPH21_RS20040 f1f028ceb8fa2abb029c007d7cae4044 276 Gene3D G3DSA:3.40.50.1820 43 254 1.5E-41 T 21-04-2016 IPR029058 Alpha/Beta hydrolase fold SPH21_RS20040 f1f028ceb8fa2abb029c007d7cae4044 276 PANTHER PTHR23024 42 276 9.1E-30 T 21-04-2016 SPH21_RS19090 68f678010a9a9d978c1403f61e9a2c01 127 Gene3D G3DSA:1.10.260.40 4 57 1.8E-6 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS19090 68f678010a9a9d978c1403f61e9a2c01 127 SUPERFAMILY SSF47413 3 59 1.97E-5 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS23550 83a97cecbb4b10a3d516365cf79e7436 147 Gene3D G3DSA:3.30.530.20 2 146 1.5E-14 T 21-04-2016 IPR023393 START-like domain SPH21_RS23550 83a97cecbb4b10a3d516365cf79e7436 147 SUPERFAMILY SSF55961 1 140 3.2E-16 T 21-04-2016 SPH21_RS23550 83a97cecbb4b10a3d516365cf79e7436 147 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 11 122 1.2E-4 T 21-04-2016 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SPH21_RS13805 efcd50c3d5736ffbea68d6fbd57d18d6 238 Pfam PF10670 Domain of unknown function (DUF4198) 20 210 7.3E-9 T 21-04-2016 IPR019613 Protein of unknown function DUF4198 SPH21_RS13805 efcd50c3d5736ffbea68d6fbd57d18d6 238 SUPERFAMILY SSF49478 164 210 4.71E-5 T 21-04-2016 SPH21_RS17750 826005317156067d40046039601ab3ee 300 TIGRFAM TIGR03780 Bac_Flav_CT_N: Bacteroides conjugative transposon TraN protein 8 292 3.4E-104 T 21-04-2016 IPR022298 Conjugative transposon, TraN SPH21_RS17750 826005317156067d40046039601ab3ee 300 Pfam PF13595 Domain of unknown function (DUF4138) 43 291 9.7E-100 T 21-04-2016 IPR022298 Conjugative transposon, TraN SPH21_RS09595 1f6f5f2c1b4de36928903847e0f33cd2 323 SUPERFAMILY SSF52266 219 308 1.12E-9 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS09595 1f6f5f2c1b4de36928903847e0f33cd2 323 SUPERFAMILY SSF52266 55 128 1.12E-9 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS09595 1f6f5f2c1b4de36928903847e0f33cd2 323 Gene3D G3DSA:3.40.50.1110 62 125 5.5E-6 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS09595 1f6f5f2c1b4de36928903847e0f33cd2 323 Gene3D G3DSA:3.40.50.1110 218 308 5.5E-6 T 21-04-2016 IPR013830 SGNH hydrolase-type esterase domain SPH21_RS11500 761f9c560badc584b89acb728ff8ee26 925 SUPERFAMILY SSF55545 48 147 8.11E-6 T 21-04-2016 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like SPH21_RS02110 0f6fbbea7e75a5afaec22c63c778611a 173 Gene3D G3DSA:3.40.50.360 2 173 8.0E-29 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS02110 0f6fbbea7e75a5afaec22c63c778611a 173 SUPERFAMILY SSF52218 2 172 5.71E-31 T 21-04-2016 IPR029039 Flavoprotein-like domain SPH21_RS02110 0f6fbbea7e75a5afaec22c63c778611a 173 Pfam PF03358 NADPH-dependent FMN reductase 2 136 2.3E-22 T 21-04-2016 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SPH21_RS02110 0f6fbbea7e75a5afaec22c63c778611a 173 PANTHER PTHR30543 1 173 6.2E-24 T 21-04-2016 SPH21_RS23270 67535847f71720de8877e47c49429693 542 ProDom PD092006 MEMBRANE YWOB TRANSMEMBRANE 141 247 1.0E-10 T 21-04-2016 IPR020218 Uncharacterised protein family, YwoB, transmembrane SPH21_RS18055 aabcd13856e8d3a4e2438c4877f7dabf 176 Pfam PF11827 Protein of unknown function (DUF3347) 31 171 3.1E-39 T 21-04-2016 IPR021782 Protein of unknown function DUF3347 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 SUPERFAMILY SSF53187 151 164 3.77E-41 T 21-04-2016 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 SUPERFAMILY SSF53187 41 123 3.77E-41 T 21-04-2016 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 SUPERFAMILY SSF53187 214 288 3.77E-41 T 21-04-2016 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 PANTHER PTHR30404:SF0 151 294 1.1E-46 T 21-04-2016 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 PANTHER PTHR30404:SF0 29 123 1.1E-46 T 21-04-2016 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 Pfam PF01520 N-acetylmuramoyl-L-alanine amidase 43 286 1.2E-44 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 SMART SM00646 103 286 1.4E-18 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 Gene3D G3DSA:3.40.630.40 41 165 6.0E-54 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 Gene3D G3DSA:3.40.630.40 215 288 6.0E-54 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 PANTHER PTHR30404 151 294 1.1E-46 T 21-04-2016 SPH21_RS12565 adc4138ab41f4db33060c9660d76fea1 294 PANTHER PTHR30404 29 123 1.1E-46 T 21-04-2016 SPH21_RS01235 fd153f01be476e19b34a6f5f8dec08e1 99 Pfam PF13572 Domain of unknown function (DUF4134) 9 97 4.3E-36 T 21-04-2016 IPR025408 Protein of unknown function DUF4134 SPH21_RS05815 a1bbd2ceebd8d1b5e077a589fcae44b5 337 Pfam PF02322 Cytochrome bd terminal oxidase subunit II 3 329 1.7E-56 T 21-04-2016 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 SPH21_RS18990 57ced5e80adf6f721cf82f4ab98dbf0d 90 SUPERFAMILY SSF46785 4 82 2.78E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS18990 57ced5e80adf6f721cf82f4ab98dbf0d 90 Gene3D G3DSA:1.10.10.10 3 79 4.8E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS19280 098bfa47a700750c0e63f46b74f6cb59 116 TIGRFAM TIGR03515 GldC: gliding motility-associated protein GldC 2 110 5.8E-44 T 21-04-2016 IPR019854 Gliding motility-associated protein, GldC SPH21_RS04345 aea6864f214243d844f1d96406b309e1 294 SUPERFAMILY SSF52317 47 291 8.24E-9 T 21-04-2016 IPR029062 Class I glutamine amidotransferase-like SPH21_RS22320 632aa4ffbe7035e255849535edf88d63 135 Pfam PF06170 Protein of unknown function (DUF983) 37 116 9.4E-6 T 21-04-2016 IPR009325 Protein of unknown function DUF983 SPH21_RS13260 b2be95fb54bd102bab1bd6e980a71cee 376 SUPERFAMILY SSF56281 110 338 5.29E-31 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS13260 b2be95fb54bd102bab1bd6e980a71cee 376 PANTHER PTHR15032 57 371 3.3E-78 T 21-04-2016 SPH21_RS13260 b2be95fb54bd102bab1bd6e980a71cee 376 Gene3D G3DSA:3.60.15.10 78 373 9.1E-88 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS13260 b2be95fb54bd102bab1bd6e980a71cee 376 Pfam PF12706 Beta-lactamase superfamily domain 153 321 9.7E-36 T 21-04-2016 IPR001279 Metallo-beta-lactamase SPH21_RS13260 b2be95fb54bd102bab1bd6e980a71cee 376 PANTHER PTHR15032:SF4 57 371 3.3E-78 T 21-04-2016 SPH21_RS20035 46af7b1124df7550793305305cd66420 307 Gene3D G3DSA:2.120.10.30 37 305 3.8E-64 T 21-04-2016 IPR011042 Six-bladed beta-propeller, TolB-like SPH21_RS20035 46af7b1124df7550793305305cd66420 307 PANTHER PTHR10907:SF47 44 304 2.7E-60 T 21-04-2016 SPH21_RS20035 46af7b1124df7550793305305cd66420 307 PANTHER PTHR10907 44 304 2.7E-60 T 21-04-2016 SPH21_RS20035 46af7b1124df7550793305305cd66420 307 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 53 292 4.0E-46 T 21-04-2016 IPR013658 SMP-30/Gluconolactonase/LRE-like region SPH21_RS20035 46af7b1124df7550793305305cd66420 307 SUPERFAMILY SSF63829 33 304 4.41E-61 T 21-04-2016 SPH21_RS03140 49bdaf8bf955628d4421fa80d9f8d204 316 Pfam PF14100 Methane oxygenase PmoA 33 311 1.6E-65 T 21-04-2016 IPR029475 Methane oxygenase PmoA SPH21_RS20430 1270c4e7ddc8f1d0b27f0eef4b9bce75 265 Pfam PF05013 N-formylglutamate amidohydrolase 12 222 2.3E-28 T 21-04-2016 IPR007709 N-formylglutamate amidohydrolase SPH21_RS20430 1270c4e7ddc8f1d0b27f0eef4b9bce75 265 Gene3D G3DSA:3.40.630.40 6 199 1.6E-16 T 21-04-2016 IPR002508 Cell wall hydrolase/autolysin, catalytic GO:0008745|GO:0009253 SPH21_RS20430 1270c4e7ddc8f1d0b27f0eef4b9bce75 265 SUPERFAMILY SSF53187 5 242 1.52E-19 T 21-04-2016 SPH21_RS23305 39ca09b23146f544b3757dfde6006e7b 189 SUPERFAMILY SSF51206 4 136 4.71E-18 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS23305 39ca09b23146f544b3757dfde6006e7b 189 Gene3D G3DSA:1.10.10.10 150 184 4.7E-4 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS23305 39ca09b23146f544b3757dfde6006e7b 189 Gene3D G3DSA:2.60.120.10 1 149 6.6E-28 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS23305 39ca09b23146f544b3757dfde6006e7b 189 PANTHER PTHR24567:SF33 10 188 7.2E-26 T 21-04-2016 SPH21_RS23305 39ca09b23146f544b3757dfde6006e7b 189 PANTHER PTHR24567 10 188 7.2E-26 T 21-04-2016 SPH21_RS23305 39ca09b23146f544b3757dfde6006e7b 189 Pfam PF00027 Cyclic nucleotide-binding domain 29 111 1.7E-7 T 21-04-2016 IPR000595 Cyclic nucleotide-binding domain SPH21_RS18380 a71c3b29eb40c0cc42bde64f196f51dd 186 Pfam PF01126 Heme oxygenase 2 181 1.3E-12 T 21-04-2016 IPR016053 Haem oxygenase-like GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: REACT_9431 SPH21_RS18380 a71c3b29eb40c0cc42bde64f196f51dd 186 SUPERFAMILY SSF48613 2 182 1.02E-35 T 21-04-2016 IPR016084 Haem oxygenase-like, multi-helical Reactome: REACT_9431 SPH21_RS18380 a71c3b29eb40c0cc42bde64f196f51dd 186 Gene3D G3DSA:1.20.910.10 2 183 3.8E-48 T 21-04-2016 IPR016084 Haem oxygenase-like, multi-helical Reactome: REACT_9431 SPH21_RS20300 339ca4a5c592eed36f2d8fc65a3199ee 171 Pfam PF02472 Biopolymer transport protein ExbD/TolR 8 151 2.4E-22 T 21-04-2016 IPR003400 Biopolymer transport protein ExbD/TolR GO:0005215|GO:0006810|GO:0016020 SPH21_RS18235 54e310737291d52a219c243ef3f2d747 203 Pfam PF13412 Winged helix-turn-helix DNA-binding 155 183 7.4E-5 T 21-04-2016 SPH21_RS18235 54e310737291d52a219c243ef3f2d747 203 Gene3D G3DSA:1.10.10.10 145 182 7.2E-5 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS13625 dca20226e6ef9b10c2eec7fae290bfdb 347 Pfam PF14100 Methane oxygenase PmoA 37 340 5.4E-85 T 21-04-2016 IPR029475 Methane oxygenase PmoA SPH21_RS10380 1aae9e0d06e5d5e6860668b5d55524c9 118 Gene3D G3DSA:3.40.50.10400 3 109 4.9E-5 T 21-04-2016 IPR027269 Hypothetical PA1492 domain SPH21_RS10815 8959f67f6109266d82d749bb1716cd25 106 Pfam PF04892 VanZ like family 22 96 1.6E-9 T 21-04-2016 IPR006976 VanZ-like SPH21_RS07175 a8269fd05f500920cf34d2c1094c1b26 72 Hamap MF_00337 Exodeoxyribonuclease 7 small subunit [xseB]. 6 66 11.096 T 21-04-2016 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SPH21_RS07175 a8269fd05f500920cf34d2c1094c1b26 72 Pfam PF02609 Exonuclease VII small subunit 7 58 2.0E-14 T 21-04-2016 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SPH21_RS07175 a8269fd05f500920cf34d2c1094c1b26 72 Gene3D G3DSA:1.10.287.1040 3 69 7.5E-15 T 21-04-2016 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SPH21_RS07175 a8269fd05f500920cf34d2c1094c1b26 72 TIGRFAM TIGR01280 xseB: exodeoxyribonuclease VII, small subunit 6 62 2.4E-16 T 21-04-2016 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SPH21_RS07175 a8269fd05f500920cf34d2c1094c1b26 72 SUPERFAMILY SSF116842 3 66 1.57E-13 T 21-04-2016 SPH21_RS02920 0701d0d9acd3115300e05a679acb4dbf 93 Gene3D G3DSA:1.10.260.40 1 82 8.3E-16 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS02920 0701d0d9acd3115300e05a679acb4dbf 93 Pfam PF01381 Helix-turn-helix 1 46 1.5E-12 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS02920 0701d0d9acd3115300e05a679acb4dbf 93 PANTHER PTHR10245 1 72 8.7E-12 T 21-04-2016 SPH21_RS02920 0701d0d9acd3115300e05a679acb4dbf 93 SUPERFAMILY SSF47413 1 52 6.17E-12 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS02920 0701d0d9acd3115300e05a679acb4dbf 93 SMART SM00530 2 46 1.5E-6 T 21-04-2016 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SPH21_RS03790 b9ab2974f95e25403b0c0a6189710b15 258 SUPERFAMILY SSF49464 25 102 5.49E-5 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS09425 278c73964dccd486fc0a4f3d5439b609 547 SUPERFAMILY SSF53649 264 527 4.04E-56 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS09425 278c73964dccd486fc0a4f3d5439b609 547 SUPERFAMILY SSF53649 18 219 4.04E-56 T 21-04-2016 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SPH21_RS09425 278c73964dccd486fc0a4f3d5439b609 547 Gene3D G3DSA:3.40.720.10 263 358 7.6E-63 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS09425 278c73964dccd486fc0a4f3d5439b609 547 Gene3D G3DSA:3.40.720.10 9 205 7.6E-63 T 21-04-2016 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SPH21_RS09425 278c73964dccd486fc0a4f3d5439b609 547 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 31 482 1.2E-53 T 21-04-2016 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SPH21_RS09425 278c73964dccd486fc0a4f3d5439b609 547 PIRSF PIRSF031924 13 547 1.5E-122 T 21-04-2016 IPR026263 Alkaline phosphatase, prokaryotic KEGG: 00627+3.1.3.1|KEGG: 00790+3.1.3.1|MetaCyc: PWY-5083|MetaCyc: PWY-5491 SPH21_RS05885 621450b8c9d57b11b460df8fed3a603c 217 SUPERFAMILY SSF158949 78 199 1.01E-14 T 21-04-2016 IPR018598 Domain of unknown function DUF2027 SPH21_RS04070 af107a86bf23bdc3b42b0be6cf8c345c 385 Pfam PF12704 MacB-like periplasmic core domain 23 262 5.8E-18 T 21-04-2016 IPR025857 MacB-like periplasmic core domain SPH21_RS04070 af107a86bf23bdc3b42b0be6cf8c345c 385 PANTHER PTHR30572:SF4 302 374 7.5E-15 T 21-04-2016 SPH21_RS04070 af107a86bf23bdc3b42b0be6cf8c345c 385 PANTHER PTHR30572 302 374 7.5E-15 T 21-04-2016 SPH21_RS04070 af107a86bf23bdc3b42b0be6cf8c345c 385 Pfam PF02687 FtsX-like permease family 311 384 6.2E-11 T 21-04-2016 IPR003838 ABC transporter permease protein domain GO:0016020 SPH21_RS25880 9cdf913b52d0a9c08354dce29a835add 96 Pfam PF05258 Protein of unknown function (DUF721) 9 95 8.4E-19 T 21-04-2016 IPR007922 Protein of unknown function DUF721/UPF0232 SPH21_RS21110 6b01ea485f81872a840bf9e258d77afd 684 SUPERFAMILY SSF51445 286 378 4.16E-23 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS21110 6b01ea485f81872a840bf9e258d77afd 684 SUPERFAMILY SSF51445 415 571 4.16E-23 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS21110 6b01ea485f81872a840bf9e258d77afd 684 Gene3D G3DSA:3.20.20.70 286 546 1.1E-19 T 21-04-2016 IPR013785 Aldolase-type TIM barrel GO:0003824 SPH21_RS21110 6b01ea485f81872a840bf9e258d77afd 684 Gene3D G3DSA:2.60.40.1180 616 682 2.6E-5 T 21-04-2016 IPR013780 Glycosyl hydrolase, all-beta SPH21_RS19495 c8d29f313b3f1d30941a26ebea487cc1 535 Pfam PF14322 Starch-binding associating with outer membrane 103 229 2.7E-20 T 21-04-2016 SPH21_RS19495 c8d29f313b3f1d30941a26ebea487cc1 535 Gene3D G3DSA:1.25.40.10 209 465 7.9E-34 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS19495 c8d29f313b3f1d30941a26ebea487cc1 535 Pfam PF07980 SusD family 285 535 7.5E-23 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS19495 c8d29f313b3f1d30941a26ebea487cc1 535 SUPERFAMILY SSF48452 19 535 4.3E-99 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09135 1fd49e98ae04a0f4dd7d870c9b0ba2b5 101 Pfam PF10543 ORF6N domain 23 84 1.6E-22 T 21-04-2016 IPR018873 KilA-N, DNA-binding domain SPH21_RS21420 e05a16df851190bce9e3376c3c2215b3 136 Gene3D G3DSA:1.10.260.40 3 61 2.6E-5 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS21420 e05a16df851190bce9e3376c3c2215b3 136 SUPERFAMILY SSF47413 4 63 2.48E-5 T 21-04-2016 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SPH21_RS21150 77e0cacf348f0d1ee04b04f4f4f3f620 369 Pfam PF00211 Adenylate and Guanylate cyclase catalytic domain 183 355 2.2E-15 T 21-04-2016 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SPH21_RS21150 77e0cacf348f0d1ee04b04f4f4f3f620 369 Gene3D G3DSA:3.30.70.1230 179 359 1.7E-22 T 21-04-2016 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SPH21_RS21150 77e0cacf348f0d1ee04b04f4f4f3f620 369 SUPERFAMILY SSF55073 174 362 2.51E-34 T 21-04-2016 IPR029787 Nucleotide cyclase SPH21_RS17315 cb481c00069ae2d938a01b4bffe8c871 72 SUPERFAMILY SSF51344 5 57 6.67E-5 T 21-04-2016 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS17315 cb481c00069ae2d938a01b4bffe8c871 72 Pfam PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 5 57 2.1E-4 T 21-04-2016 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS17315 cb481c00069ae2d938a01b4bffe8c871 72 Gene3D G3DSA:2.60.15.10 5 57 1.4E-4 T 21-04-2016 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 SPH21_RS11040 9f69c10cd40273d1e4222325587210b9 417 Pfam PF00999 Sodium/hydrogen exchanger family 9 406 2.9E-61 T 21-04-2016 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SPH21_RS11040 9f69c10cd40273d1e4222325587210b9 417 PANTHER PTHR10110 7 403 6.0E-84 T 21-04-2016 IPR018422 Cation/H+ exchanger, CPA1 family GO:0006812|GO:0015299|GO:0016021 Reactome: REACT_15518 SPH21_RS11040 9f69c10cd40273d1e4222325587210b9 417 PANTHER PTHR10110:SF86 7 403 6.0E-84 T 21-04-2016 SPH21_RS00700 b598116a86c0eeab743c0d5eb9bb4c3f 67 Gene3D G3DSA:3.10.20.30 1 62 9.4E-4 T 21-04-2016 IPR012675 Beta-grasp domain SPH21_RS01695 98881ffb769b8bb51a0f41874c036947 689 Pfam PF14121 Putative porin 54 689 3.1E-144 T 21-04-2016 IPR025631 Putative porin-10 SPH21_RS12560 9e0902f425cbe87a21fb13040fd54935 323 Pfam PF02470 MlaD protein 38 108 6.9E-13 T 21-04-2016 IPR003399 Mce/MlaD SPH21_RS12560 9e0902f425cbe87a21fb13040fd54935 323 PANTHER PTHR33371:SF4 1 309 8.1E-25 T 21-04-2016 SPH21_RS12560 9e0902f425cbe87a21fb13040fd54935 323 PANTHER PTHR33371 1 309 8.1E-25 T 21-04-2016 SPH21_RS19055 00bd11a29d1f409611e33e65c9b32c94 148 Gene3D G3DSA:1.20.1250.20 11 75 6.4E-4 T 21-04-2016 SPH21_RS19055 00bd11a29d1f409611e33e65c9b32c94 148 Pfam PF04120 Low affinity iron permease 7 131 8.5E-57 T 21-04-2016 IPR007251 Low affinity iron permease, Fet4 GO:0055085 SPH21_RS26235 41631b95090cdb96c24abec552a8bb40 303 Pfam PF09922 Cell wall-active antibiotics response 4TMS YvqF 201 271 2.1E-7 T 21-04-2016 IPR024425 Cell wall-active antibiotics response 4TMS YvqF SPH21_RS06220 3e6cd3e5fe55c0a428b83fa296361777 265 PANTHER PTHR33570 1 128 9.4E-36 T 21-04-2016 SPH21_RS06220 3e6cd3e5fe55c0a428b83fa296361777 265 Pfam PF02627 Carboxymuconolactone decarboxylase family 172 256 5.0E-16 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS06220 3e6cd3e5fe55c0a428b83fa296361777 265 Pfam PF02627 Carboxymuconolactone decarboxylase family 33 116 1.9E-16 T 21-04-2016 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SPH21_RS06220 3e6cd3e5fe55c0a428b83fa296361777 265 SUPERFAMILY SSF69118 1 262 1.13E-63 T 21-04-2016 IPR029032 AhpD-like SPH21_RS06220 3e6cd3e5fe55c0a428b83fa296361777 265 PANTHER PTHR33570:SF4 1 128 9.4E-36 T 21-04-2016 SPH21_RS06220 3e6cd3e5fe55c0a428b83fa296361777 265 Gene3D G3DSA:1.20.1290.10 1 130 1.8E-34 T 21-04-2016 IPR029032 AhpD-like SPH21_RS06220 3e6cd3e5fe55c0a428b83fa296361777 265 Gene3D G3DSA:1.20.1290.10 142 263 4.7E-29 T 21-04-2016 IPR029032 AhpD-like SPH21_RS11155 092dfb226c4854ac7e6730c640a0db1b 359 Pfam PF04773 FecR protein 146 232 2.7E-17 T 21-04-2016 IPR006860 FecR protein SPH21_RS11155 092dfb226c4854ac7e6730c640a0db1b 359 PANTHER PTHR30273:SF2 5 359 1.2E-44 T 21-04-2016 SPH21_RS11155 092dfb226c4854ac7e6730c640a0db1b 359 Pfam PF16344 Domain of unknown function (DUF4974) 248 353 8.1E-13 T 21-04-2016 IPR032508 Protein FecR, C-terminal SPH21_RS11155 092dfb226c4854ac7e6730c640a0db1b 359 PANTHER PTHR30273 5 359 1.2E-44 T 21-04-2016 IPR012373 Fe(2+)-dicitrate sensor, transmembrane component SPH21_RS08085 ee3e784fca8e33499904e947719cf890 512 Pfam PF14092 Domain of unknown function (DUF4270) 67 510 2.3E-45 T 21-04-2016 IPR025366 Protein of unknown function DUF4270 SPH21_RS01045 af3bb252c0ff76b4b1d509b433abb11d 200 SUPERFAMILY SSF109854 23 193 6.56E-20 T 21-04-2016 SPH21_RS01045 af3bb252c0ff76b4b1d509b433abb11d 200 Pfam PF12867 DinB superfamily 34 188 1.0E-16 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS01045 af3bb252c0ff76b4b1d509b433abb11d 200 Gene3D G3DSA:1.20.120.450 24 194 8.8E-23 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS18730 80dca44003c135e997209797321e5d95 523 Pfam PF05299 M61 glycyl aminopeptidase 307 413 1.3E-14 T 21-04-2016 IPR007963 Peptidase M61, catalytic domain SPH21_RS18730 80dca44003c135e997209797321e5d95 523 SUPERFAMILY SSF55486 221 422 1.32E-8 T 21-04-2016 SPH21_RS19205 875a0520c8ba58bafce9f9f7cd8c2c86 129 Pfam PF07843 Protein of unknown function (DUF1634) 15 124 3.9E-28 T 21-04-2016 IPR012861 Protein of unknown function DUF1634 SPH21_RS18895 f9279297404e0e1c1ead85b4140c3592 239 Pfam PF08867 FRG domain 29 117 1.0E-21 T 21-04-2016 IPR014966 FRG domain SPH21_RS18895 f9279297404e0e1c1ead85b4140c3592 239 SMART SM00901 26 128 2.3E-26 T 21-04-2016 IPR014966 FRG domain SPH21_RS03850 92e71deae1c9967ba1111d0feb25d783 98 Pfam PF13591 MerR HTH family regulatory protein 7 88 6.1E-22 T 21-04-2016 SPH21_RS08310 6b143d8f0ce4782dd245484968d32f9f 318 Gene3D G3DSA:3.10.50.40 22 203 1.8E-9 T 21-04-2016 SPH21_RS08310 6b143d8f0ce4782dd245484968d32f9f 318 Gene3D G3DSA:3.10.50.40 204 316 5.8E-19 T 21-04-2016 SPH21_RS08310 6b143d8f0ce4782dd245484968d32f9f 318 SUPERFAMILY SSF54534 207 311 6.68E-17 T 21-04-2016 SPH21_RS08310 6b143d8f0ce4782dd245484968d32f9f 318 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 232 311 1.1E-5 T 21-04-2016 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SPH21_RS13880 1dac993b598316e19d7e5909084f28bc 152 Pfam PF11026 Protein of unknown function (DUF2721) 5 122 3.1E-35 T 21-04-2016 IPR021279 Protein of unknown function DUF2721 SPH21_RS10715 8986fe593a6e6d77e9fd04d4378ef067 118 SUPERFAMILY SSF55785 29 106 7.04E-6 T 21-04-2016 IPR000014 PAS domain SPH21_RS10715 8986fe593a6e6d77e9fd04d4378ef067 118 Gene3D G3DSA:3.30.450.20 29 105 2.3E-4 T 21-04-2016 SPH21_RS17985 ae9cf16c05ee463807195855c0798937 1564 Gene3D G3DSA:3.40.50.300 204 313 2.3E-7 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS17985 ae9cf16c05ee463807195855c0798937 1564 SUPERFAMILY SSF52540 195 356 4.41E-10 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS09325 3cec54303abd4b82b02019bc010f64bc 432 Pfam PF14322 Starch-binding associating with outer membrane 31 215 4.9E-24 T 21-04-2016 SPH21_RS09325 3cec54303abd4b82b02019bc010f64bc 432 Pfam PF07980 SusD family 319 432 3.9E-15 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS09325 3cec54303abd4b82b02019bc010f64bc 432 Gene3D G3DSA:1.25.40.10 197 384 1.9E-21 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09325 3cec54303abd4b82b02019bc010f64bc 432 SUPERFAMILY SSF48452 26 432 7.97E-88 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS09320 cbf6b5ce7feaf4992fd4827e8a893ff1 304 Pfam PF09992 Phosphodiester glycosidase 125 299 9.3E-37 T 21-04-2016 IPR018711 Phosphodiester glycosidase SPH21_RS04835 6db11af9292b361dbb9eb9b737968e5b 224 PANTHER PTHR15629 33 195 1.7E-46 T 21-04-2016 SPH21_RS04835 6db11af9292b361dbb9eb9b737968e5b 224 Pfam PF04366 Las17-binding protein actin regulator 102 221 3.7E-30 T 21-04-2016 IPR007461 Ysc84 actin-binding domain SPH21_RS24495 154c54e3238fc125efe53e1d39c70de5 393 Pfam PF17170 6-bladed beta-propeller 29 324 3.7E-20 T 21-04-2016 SPH21_RS10995 b8bc4772409d72acb5e7522192e11344 281 PANTHER PTHR30168 2 281 2.0E-124 T 21-04-2016 SPH21_RS10995 b8bc4772409d72acb5e7522192e11344 281 Pfam PF04228 Putative neutral zinc metallopeptidase 1 277 2.3E-111 T 21-04-2016 IPR007343 Uncharacterised protein family, zinc metallopeptidase putative SPH21_RS13380 63c66e2acb1db15488a3310aef472a7a 103 Pfam PF14542 GCN5-related N-acetyl-transferase 18 94 1.1E-21 T 21-04-2016 IPR031165 Yjdj-type Gcn5-related N-acetyltransferase SPH21_RS13380 63c66e2acb1db15488a3310aef472a7a 103 Gene3D G3DSA:3.40.630.30 8 95 2.4E-24 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS13380 63c66e2acb1db15488a3310aef472a7a 103 PANTHER PTHR31435 1 100 2.2E-19 T 21-04-2016 SPH21_RS13380 63c66e2acb1db15488a3310aef472a7a 103 SUPERFAMILY SSF55729 11 96 1.59E-22 T 21-04-2016 IPR016181 Acyl-CoA N-acyltransferase SPH21_RS11340 7c767ed6aae3ae88b824f263dfa91962 520 SUPERFAMILY SSF48208 74 506 1.02E-39 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS01570 fe3cac59592c934fd20c799b75a97c9b 243 SUPERFAMILY SSF56925 76 196 7.85E-5 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS24435 0b2e9d1f0b70a7b3be59a73b03404f3f 316 TIGRFAM TIGR04033 export_SdpB: antimicrobial peptide system protein, SdpB family 13 284 1.6E-71 T 21-04-2016 IPR023894 Sporulation delaying protein SdpB SPH21_RS24435 0b2e9d1f0b70a7b3be59a73b03404f3f 316 ProDom PD031536 MEMBRANE TRANSMEMBRANE YVAX YITN 188 288 3.0E-10 T 21-04-2016 SPH21_RS24435 0b2e9d1f0b70a7b3be59a73b03404f3f 316 ProDom PD027642 TRANSMEMBRANE MEMBRANE YVAX YITO 89 139 4.0E-9 T 21-04-2016 SPH21_RS24435 0b2e9d1f0b70a7b3be59a73b03404f3f 316 SMART SM00752 12 285 2.9E-25 T 21-04-2016 IPR011020 HTTM SPH21_RS17410 e991f1b3acd93a235da601cea26fd834 185 Gene3D G3DSA:1.10.3210.10 21 183 1.5E-38 T 21-04-2016 IPR006674 HD domain SPH21_RS17410 e991f1b3acd93a235da601cea26fd834 185 SUPERFAMILY SSF109604 22 170 2.48E-33 T 21-04-2016 SPH21_RS18240 501401dc4ff319295ecd2a8f86bc651e 236 Pfam PF11750 Protein of unknown function (DUF3307) 3 110 6.0E-32 T 21-04-2016 IPR021737 Bacteriophage phiKZ, Orf197 SPH21_RS13640 0ca55debf27fc0d5c5b330fc2da08616 129 Pfam PF16231 Domain of unknown function (DUF4890) 20 108 4.7E-7 T 21-04-2016 IPR032612 Protein of unknown function DUF4890 SPH21_RS09915 2d81bb38acd67f274abbe9c34f70e015 344 TIGRFAM TIGR03523 GldN: gliding motility associated protein GldN 64 297 1.4E-31 T 21-04-2016 IPR019847 Gliding motility associated protein GldN SPH21_RS06750 0e8f5c08eda1e044b7343b4063b4ed56 335 Pfam PF01384 Phosphate transporter family 172 324 7.3E-51 T 21-04-2016 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: REACT_15518 SPH21_RS06750 0e8f5c08eda1e044b7343b4063b4ed56 335 Pfam PF01384 Phosphate transporter family 19 166 2.3E-36 T 21-04-2016 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: REACT_15518 SPH21_RS06750 0e8f5c08eda1e044b7343b4063b4ed56 335 PANTHER PTHR11101 1 335 1.6E-83 T 21-04-2016 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: REACT_15518 SPH21_RS07675 8c0ac53d2a7704c33c525ba1e901ac7d 178 PANTHER PTHR40394 7 167 1.4E-16 T 21-04-2016 SPH21_RS07675 8c0ac53d2a7704c33c525ba1e901ac7d 178 Pfam PF11821 Protein of unknown function (DUF3341) 5 167 8.1E-58 T 21-04-2016 IPR021776 Protein of unknown function DUF3341 SPH21_RS08160 da5be4198050167098bb0334b7481740 329 PANTHER PTHR11732 1 319 1.2E-138 T 21-04-2016 IPR001395 Aldo/keto reductase/potassium channel subunit beta SPH21_RS08160 da5be4198050167098bb0334b7481740 329 Gene3D G3DSA:3.20.20.100 1 320 3.2E-105 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS08160 da5be4198050167098bb0334b7481740 329 PRINTS PR01577 KCNAB voltage-gated K+ channel beta subunit family signature 114 124 5.0E-12 T 21-04-2016 IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related SPH21_RS08160 da5be4198050167098bb0334b7481740 329 PRINTS PR01577 KCNAB voltage-gated K+ channel beta subunit family signature 165 184 5.0E-12 T 21-04-2016 IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related SPH21_RS08160 da5be4198050167098bb0334b7481740 329 PRINTS PR01577 KCNAB voltage-gated K+ channel beta subunit family signature 210 216 5.0E-12 T 21-04-2016 IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related SPH21_RS08160 da5be4198050167098bb0334b7481740 329 PRINTS PR01577 KCNAB voltage-gated K+ channel beta subunit family signature 261 273 5.0E-12 T 21-04-2016 IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related SPH21_RS08160 da5be4198050167098bb0334b7481740 329 PRINTS PR01577 KCNAB voltage-gated K+ channel beta subunit family signature 274 287 5.0E-12 T 21-04-2016 IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related SPH21_RS08160 da5be4198050167098bb0334b7481740 329 SUPERFAMILY SSF51430 1 320 2.36E-96 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS08160 da5be4198050167098bb0334b7481740 329 Pfam PF00248 Aldo/keto reductase family 16 320 1.4E-71 T 21-04-2016 IPR023210 NADP-dependent oxidoreductase domain SPH21_RS04165 85c2d8b17d1a86a03d0edf3fb8d381f9 150 Gene3D G3DSA:3.30.70.1060 36 142 1.4E-6 T 21-04-2016 SPH21_RS04165 85c2d8b17d1a86a03d0edf3fb8d381f9 150 SUPERFAMILY SSF54909 49 142 6.43E-6 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 Gene3D G3DSA:2.115.10.20 55 148 2.6E-95 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 Gene3D G3DSA:2.115.10.20 247 492 2.6E-95 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 PANTHER PTHR34106:SF4 3 150 3.9E-139 T 21-04-2016 SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 PANTHER PTHR34106:SF4 237 495 3.9E-139 T 21-04-2016 SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 PANTHER PTHR34106 3 150 3.9E-139 T 21-04-2016 SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 PANTHER PTHR34106 237 495 3.9E-139 T 21-04-2016 SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 SUPERFAMILY SSF75005 269 482 3.77E-53 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS10445 e634098c1f4c5e498197c1986c40166f 497 Pfam PF04041 beta-1,4-mannooligosaccharide phosphorylase 264 485 6.5E-23 T 21-04-2016 IPR007184 Mannoside phosphorylase SPH21_RS12765 b593c027afbdadf41c13caca705a1a18 541 SUPERFAMILY SSF51126 50 335 3.14E-61 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS12765 b593c027afbdadf41c13caca705a1a18 541 SUPERFAMILY SSF51126 362 427 3.14E-61 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS12765 b593c027afbdadf41c13caca705a1a18 541 Gene3D G3DSA:4.10.1080.10 492 529 9.8E-4 T 21-04-2016 IPR028974 TSP type-3 repeat GO:0005509 SPH21_RS12765 b593c027afbdadf41c13caca705a1a18 541 Gene3D G3DSA:2.160.20.10 69 424 4.4E-52 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS12765 b593c027afbdadf41c13caca705a1a18 541 PANTHER PTHR31683:SF9 81 415 1.2E-120 T 21-04-2016 SPH21_RS12765 b593c027afbdadf41c13caca705a1a18 541 PANTHER PTHR31683 81 415 1.2E-120 T 21-04-2016 SPH21_RS06435 b21f63c21dc97de4c38f1c9baa05b9d5 170 Pfam PF11138 Protein of unknown function (DUF2911) 29 168 4.7E-47 T 21-04-2016 IPR021314 Protein of unknown function DUF2911 SPH21_RS19545 37a1c1bf03afcd4d71e4a6aeed4c5e66 324 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 8 307 2.9E-31 T 21-04-2016 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SPH21_RS08060 28e30179e45a1c5a63b58a808e79349a 492 Pfam PF14667 Polysaccharide biosynthesis C-terminal domain 344 474 4.3E-8 T 21-04-2016 IPR029303 Polysaccharide biosynthesis protein, C-terminal domain SPH21_RS08060 28e30179e45a1c5a63b58a808e79349a 492 Pfam PF01943 Polysaccharide biosynthesis protein 16 268 1.5E-8 T 21-04-2016 IPR002797 Polysaccharide biosynthesis protein GO:0016020 SPH21_RS02020 6ae223c41156680a75803d486a467602 210 SUPERFAMILY SSF53807 36 195 1.33E-15 T 21-04-2016 SPH21_RS02020 6ae223c41156680a75803d486a467602 210 Gene3D G3DSA:3.40.50.1980 145 195 2.4E-6 T 21-04-2016 SPH21_RS20110 c64651471a6ddc7778b7231ab9fe2345 213 Gene3D G3DSA:2.130.10.130 70 163 1.8E-5 T 21-04-2016 SPH21_RS10360 85534153dd34a1ce951ec01dcd3ae3eb 127 Pfam PF10861 Protein of Unknown function (DUF2784) 8 119 3.5E-25 T 21-04-2016 IPR021218 Protein of unknown function DUF2784 SPH21_RS09315 a1a41fca69fd2b6b15c272ea427f5277 523 SUPERFAMILY SSF51445 400 453 8.99E-8 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS09315 a1a41fca69fd2b6b15c272ea427f5277 523 SUPERFAMILY SSF51445 100 335 8.99E-8 T 21-04-2016 IPR017853 Glycoside hydrolase superfamily SPH21_RS09315 a1a41fca69fd2b6b15c272ea427f5277 523 Pfam PF16116 Domain of unknown function (DUF4832) 375 496 3.4E-7 T 21-04-2016 IPR032267 Domain of unknown function DUF4832 SPH21_RS21845 aa84da9a902630e9c3deffa39ce29da1 480 Pfam PF07980 SusD family 337 480 3.8E-36 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS21845 aa84da9a902630e9c3deffa39ce29da1 480 SUPERFAMILY SSF48452 18 480 5.06E-134 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS21845 aa84da9a902630e9c3deffa39ce29da1 480 Pfam PF14322 Starch-binding associating with outer membrane 24 224 3.1E-28 T 21-04-2016 SPH21_RS21845 aa84da9a902630e9c3deffa39ce29da1 480 Gene3D G3DSA:1.25.40.10 204 427 1.1E-43 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS02340 db4428ea0c108543949c20bd23a10354 420 SUPERFAMILY SSF82171 99 183 3.14E-18 T 21-04-2016 SPH21_RS02340 db4428ea0c108543949c20bd23a10354 420 SUPERFAMILY SSF82171 210 416 3.14E-18 T 21-04-2016 SPH21_RS02340 db4428ea0c108543949c20bd23a10354 420 Gene3D G3DSA:2.130.10.10 31 417 1.9E-49 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS02340 db4428ea0c108543949c20bd23a10354 420 Pfam PF14583 Oligogalacturonate lyase 100 415 1.9E-16 T 21-04-2016 IPR027946 Oligogalacturonate lyase domain GO:0045490|GO:0047487 KEGG: 00040+4.2.2.6|UniPathway: UPA00545 SPH21_RS21955 ca87aea8d88f58667138b588891bf0a1 167 Pfam PF02517 CAAX protease self-immunity 59 155 2.6E-8 T 21-04-2016 IPR003675 CAAX amino terminal protease GO:0016020 SPH21_RS09665 4c7f60df306b4504a9cd25a751a29944 465 Pfam PF14052 Capsule assembly protein Wzi 38 343 1.7E-27 T 21-04-2016 IPR026950 Capsule assembly protein Wzi SPH21_RS14595 863aae4d82583d3fd81eb06015c2cb7c 155 SUPERFAMILY SSF55811 5 150 2.98E-16 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS14595 863aae4d82583d3fd81eb06015c2cb7c 155 Pfam PF00293 NUDIX domain 8 134 1.2E-12 T 21-04-2016 IPR000086 NUDIX hydrolase domain GO:0016787 SPH21_RS14595 863aae4d82583d3fd81eb06015c2cb7c 155 Gene3D G3DSA:3.90.79.10 6 153 8.7E-18 T 21-04-2016 IPR015797 NUDIX hydrolase domain-like GO:0016787 SPH21_RS10205 ee6b2379dc6dec12a63fb9f4ffe934ba 402 Pfam PF04932 O-Antigen ligase 204 334 3.0E-9 T 21-04-2016 IPR007016 O-antigen ligase-related SPH21_RS19420 03373a536fd494ead7291f3f371cdd56 171 TIGRFAM TIGR04183 Por_Secre_tail: Por secretion system C-terminal sorting domain 92 168 4.2E-10 T 21-04-2016 IPR026444 Secretion system C-terminal sorting domain SPH21_RS10765 e8fc4ca0b6133df16917aeda643e2eb8 125 Pfam PF03779 SPW repeat 15 52 4.0E-5 T 21-04-2016 IPR005530 SPW repeat SPH21_RS10765 e8fc4ca0b6133df16917aeda643e2eb8 125 Pfam PF03779 SPW repeat 73 110 2.1E-5 T 21-04-2016 IPR005530 SPW repeat SPH21_RS18510 0e410c9595524f44d7416f365717f1ae 264 Pfam PF14054 Domain of unknown function (DUF4249) 3 259 5.1E-32 T 21-04-2016 IPR025345 Protein of unknown function DUF4249 SPH21_RS13920 c840970fa39c0ce16c08bac1a9e759b8 186 Pfam PF06037 Bacterial protein of unknown function (DUF922) 97 161 5.4E-6 T 21-04-2016 IPR010321 Protein of unknown function DUF922 SPH21_RS00530 6a97dbe85241803db87b8debde6d5879 729 SUPERFAMILY SSF48208 314 655 3.33E-8 T 21-04-2016 IPR008928 Six-hairpin glycosidase-like GO:0003824 SPH21_RS08155 6ac24ae9a61dcc8c6e9cafc34cb4cff3 625 Gene3D G3DSA:1.25.40.10 445 533 1.3E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08155 6ac24ae9a61dcc8c6e9cafc34cb4cff3 625 Gene3D G3DSA:1.25.40.10 203 356 1.3E-30 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08155 6ac24ae9a61dcc8c6e9cafc34cb4cff3 625 SUPERFAMILY SSF48452 20 228 9.74E-107 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08155 6ac24ae9a61dcc8c6e9cafc34cb4cff3 625 SUPERFAMILY SSF48452 257 560 9.74E-107 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08155 6ac24ae9a61dcc8c6e9cafc34cb4cff3 625 SUPERFAMILY SSF48452 593 625 9.74E-107 T 21-04-2016 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SPH21_RS08155 6ac24ae9a61dcc8c6e9cafc34cb4cff3 625 Pfam PF07980 SusD family 326 625 9.5E-55 T 21-04-2016 IPR012944 RagB/SusD domain SPH21_RS08155 6ac24ae9a61dcc8c6e9cafc34cb4cff3 625 Pfam PF14322 Starch-binding associating with outer membrane 24 220 5.5E-28 T 21-04-2016 SPH21_RS23810 9398e2c0dfeddb4bc7f279d1d810a45c 403 Pfam PF00668 Condensation domain 28 156 1.3E-10 T 21-04-2016 IPR001242 Condensation domain SPH21_RS23810 9398e2c0dfeddb4bc7f279d1d810a45c 403 SUPERFAMILY SSF52777 168 367 1.33E-12 T 21-04-2016 SPH21_RS23810 9398e2c0dfeddb4bc7f279d1d810a45c 403 SUPERFAMILY SSF52777 11 154 1.89E-21 T 21-04-2016 SPH21_RS10235 047ccc188064bb40d546cf1b681120e3 67 Pfam PF02416 mttA/Hcf106 family 10 51 5.8E-13 T 21-04-2016 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 SPH21_RS10235 047ccc188064bb40d546cf1b681120e3 67 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA]. 7 63 16.281 T 21-04-2016 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 SPH21_RS06180 3f3604845c33523a3620435a836f1e01 284 Pfam PF03279 Bacterial lipid A biosynthesis acyltransferase 2 277 1.9E-38 T 21-04-2016 IPR004960 Bacterial lipid A biosynthesis acyltransferase GO:0016021|GO:0016740 SPH21_RS06180 3f3604845c33523a3620435a836f1e01 284 PANTHER PTHR30606 1 277 4.0E-48 T 21-04-2016 SPH21_RS07080 105f896daaaa2cf950c273cbbda131d3 172 Pfam PF12867 DinB superfamily 30 161 2.4E-11 T 21-04-2016 IPR024775 DinB-like domain SPH21_RS07080 105f896daaaa2cf950c273cbbda131d3 172 Gene3D G3DSA:1.20.120.450 12 168 6.8E-38 T 21-04-2016 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SPH21_RS07080 105f896daaaa2cf950c273cbbda131d3 172 SUPERFAMILY SSF109854 18 165 6.26E-26 T 21-04-2016 SPH21_RS17700 40dc6a11ea6ffcce7204d5f850c8d91b 177 Pfam PF07275 Antirestriction protein (ArdA) 12 173 8.0E-36 T 21-04-2016 IPR009899 Antirestriction SPH21_RS10035 aff57781e09bcdc1dd45b3a644c233c7 381 Pfam PF00534 Glycosyl transferases group 1 197 329 7.7E-23 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS10035 aff57781e09bcdc1dd45b3a644c233c7 381 PANTHER PTHR12526 4 362 2.8E-38 T 21-04-2016 SPH21_RS10035 aff57781e09bcdc1dd45b3a644c233c7 381 SUPERFAMILY SSF53756 5 348 2.63E-52 T 21-04-2016 SPH21_RS10035 aff57781e09bcdc1dd45b3a644c233c7 381 Gene3D G3DSA:3.40.50.2000 198 341 1.3E-14 T 21-04-2016 SPH21_RS08035 1ded47f069334130ae11388795874839 816 PANTHER PTHR38454 1 810 3.2E-30 T 21-04-2016 SPH21_RS08035 1ded47f069334130ae11388795874839 816 PANTHER PTHR38454:SF1 1 810 3.2E-30 T 21-04-2016 SPH21_RS08035 1ded47f069334130ae11388795874839 816 Pfam PF09586 Bacterial membrane protein YfhO 710 791 2.1E-10 T 21-04-2016 IPR018580 Uncharacterised protein family YfhO SPH21_RS02330 b3ae44cea1af4261c73d9f1a1165b9f3 478 SUPERFAMILY SSF51126 33 382 7.33E-44 T 21-04-2016 IPR011050 Pectin lyase fold/virulence factor SPH21_RS02330 b3ae44cea1af4261c73d9f1a1165b9f3 478 PANTHER PTHR31683:SF9 43 307 3.4E-78 T 21-04-2016 SPH21_RS02330 b3ae44cea1af4261c73d9f1a1165b9f3 478 Gene3D G3DSA:2.160.20.10 44 380 1.6E-41 T 21-04-2016 IPR012334 Pectin lyase fold SPH21_RS02330 b3ae44cea1af4261c73d9f1a1165b9f3 478 PANTHER PTHR31683 43 307 3.4E-78 T 21-04-2016 SPH21_RS10695 ad2da9e2a1d49b677b8f36fdfe22b439 150 Pfam PF04239 Protein of unknown function (DUF421) 84 147 3.9E-12 T 21-04-2016 IPR007353 Protein of unknown function DUF421 SPH21_RS10695 ad2da9e2a1d49b677b8f36fdfe22b439 150 PANTHER PTHR34582 1 146 1.9E-25 T 21-04-2016 SPH21_RS10695 ad2da9e2a1d49b677b8f36fdfe22b439 150 Gene3D G3DSA:3.30.240.20 78 147 4.9E-19 T 21-04-2016 IPR023090 Uncharacterised domain UPF0702, alpha/beta domain SPH21_RS21385 b26554462339615b246474ff10c24db2 125 Gene3D G3DSA:1.10.10.60 8 49 1.2E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS18165 b79797c69f11b6942ba22660762bb68a 197 Pfam PF13036 Peptidoglycan-synthase activator LpoB 12 191 9.7E-48 T 21-04-2016 IPR014094 Penicillin-binding protein activator LpoB SPH21_RS09395 6241398594bfdd0fe3b2daf8c7f340dc 742 Gene3D G3DSA:2.130.10.10 124 251 3.8E-6 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS09395 6241398594bfdd0fe3b2daf8c7f340dc 742 Gene3D G3DSA:2.130.10.10 299 317 3.8E-6 T 21-04-2016 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SPH21_RS09395 6241398594bfdd0fe3b2daf8c7f340dc 742 SUPERFAMILY SSF63829 126 316 3.07E-7 T 21-04-2016 SPH21_RS20865 65b9e3294527c4f3644349fbd4930fcd 82 SUPERFAMILY SSF51338 28 66 9.35E-5 T 21-04-2016 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SPH21_RS22310 caae7a3858f1fde84e61ee1498893df3 127 Gene3D G3DSA:1.10.10.60 9 46 1.1E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS22065 a438c1cb0997d69cfeeb95f3ced81df5 193 Pfam PF13376 Bacteriocin-protection, YdeI or OmpD-Associated 129 187 3.1E-18 T 21-04-2016 SPH21_RS08880 d4bbaa3823b49d477e2921bc742d9ddd 363 Pfam PF02706 Chain length determinant protein 33 220 1.3E-8 T 21-04-2016 IPR003856 Lipopolysaccharide biosynthesis GO:0009103|GO:0016020 SPH21_RS04015 e8f74f292c9c651ddc370e43980d2712 214 Gene3D G3DSA:2.170.15.10 44 199 4.5E-4 T 21-04-2016 IPR023307 Aerolysin-like toxin, beta complex domain SPH21_RS17545 d3f02ec03f162a597df8af434b48b948 65 Pfam PF03597 Cytochrome oxidase maturation protein cbb3-type 2 45 5.0E-20 T 21-04-2016 IPR004714 Cytochrome oxidase maturation protein cbb3-type SPH21_RS17545 d3f02ec03f162a597df8af434b48b948 65 TIGRFAM TIGR00847 ccoS: cytochrome oxidase maturation protein, cbb3-type 1 46 6.1E-13 T 21-04-2016 IPR004714 Cytochrome oxidase maturation protein cbb3-type SPH21_RS16145 b074e4f5a6b0c8744b955e2fd9dbf6ab 246 SUPERFAMILY SSF52540 64 168 3.19E-17 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16145 b074e4f5a6b0c8744b955e2fd9dbf6ab 246 Gene3D G3DSA:3.40.50.300 64 168 2.2E-20 T 21-04-2016 IPR027417 P-loop containing nucleoside triphosphate hydrolase SPH21_RS16145 b074e4f5a6b0c8744b955e2fd9dbf6ab 246 PIRSF PIRSF034285 1 241 3.1E-48 T 21-04-2016 IPR017026 Inducible mutagenesis protein A SPH21_RS25350 5c7ffb55fd54b1cbeb1b90f43047f9e0 254 SUPERFAMILY SSF49464 25 105 7.72E-6 T 21-04-2016 IPR008969 Carboxypeptidase-like, regulatory domain SPH21_RS04495 8b9bc89558e8c874b84c083c98417043 115 SUPERFAMILY SSF54427 2 110 1.11E-13 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS04495 8b9bc89558e8c874b84c083c98417043 115 Gene3D G3DSA:3.10.450.50 1 111 2.5E-8 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS04495 8b9bc89558e8c874b84c083c98417043 115 Pfam PF12680 SnoaL-like domain 8 76 7.1E-9 T 21-04-2016 IPR009959 Polyketide cyclase SnoaL-like domain SPH21_RS10415 82ef14e00662489da9c8b07981214287 197 Pfam PF01618 MotA/TolQ/ExbB proton channel family 78 157 8.7E-11 T 21-04-2016 IPR002898 MotA/TolQ/ExbB proton channel GO:0006810|GO:0008565|GO:0016020 SPH21_RS07995 ec1e64bd6f00cfc6116530a8d12aa258 785 Gene3D G3DSA:2.60.450.10 136 232 4.3E-5 T 21-04-2016 SPH21_RS07995 ec1e64bd6f00cfc6116530a8d12aa258 785 Gene3D G3DSA:2.60.450.10 37 135 6.7E-12 T 21-04-2016 SPH21_RS07995 ec1e64bd6f00cfc6116530a8d12aa258 785 Gene3D G3DSA:2.60.450.10 514 580 1.7E-5 T 21-04-2016 SPH21_RS07995 ec1e64bd6f00cfc6116530a8d12aa258 785 Pfam PF13100 OstA-like protein 28 159 1.0E-31 T 21-04-2016 IPR005653 Organic solvent tolerance-like, N-terminal SPH21_RS17745 1c29c4df68f55452132fe6475482c897 185 Pfam PF10626 Conjugative transposon protein TraO 24 184 5.7E-61 T 21-04-2016 IPR018899 Conjugative transposon, TraO SPH21_RS12400 3531fec60997074e818e310081070408 315 Pfam PF13536 Putative multidrug resistance efflux transporter 37 298 6.5E-79 T 21-04-2016 IPR032713 Putative multidrug resistance efflux transporter SPH21_RS13860 e22bb6faa2792a97ae804565ec058bba 641 Pfam PF16120 Domain of unknown function (DUF4836) 28 157 9.3E-7 T 21-04-2016 IPR032276 Protein of unknown function DUF4836 SPH21_RS06965 b9c1ddca00459bffbd22aa05274c21b8 184 Pfam PF13505 Outer membrane protein beta-barrel domain 11 182 8.3E-10 T 21-04-2016 IPR027385 Outer membrane protein beta-barrel SPH21_RS06965 b9c1ddca00459bffbd22aa05274c21b8 184 Gene3D G3DSA:2.40.160.20 45 182 4.3E-6 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS06965 b9c1ddca00459bffbd22aa05274c21b8 184 SUPERFAMILY SSF56925 41 182 2.88E-6 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS23585 24a28042c2bcaf34d4bc10b6f6879bdd 334 SUPERFAMILY SSF48576 19 315 2.79E-34 T 21-04-2016 IPR008949 Isoprenoid synthase domain SPH21_RS23585 24a28042c2bcaf34d4bc10b6f6879bdd 334 Gene3D G3DSA:1.10.600.10 19 314 7.4E-44 T 21-04-2016 IPR008949 Isoprenoid synthase domain SPH21_RS08935 6a2ced30b946f836af60b56e710f8ced 582 Pfam PF14052 Capsule assembly protein Wzi 208 499 7.8E-15 T 21-04-2016 IPR026950 Capsule assembly protein Wzi SPH21_RS22015 ce36e0de1bccb4f00bbbcb33154d0ee7 260 SUPERFAMILY SSF54909 149 259 1.07E-15 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS22015 ce36e0de1bccb4f00bbbcb33154d0ee7 260 Gene3D G3DSA:3.30.70.900 29 140 3.0E-4 T 21-04-2016 SPH21_RS22015 ce36e0de1bccb4f00bbbcb33154d0ee7 260 Gene3D G3DSA:3.30.70.900 149 259 9.2E-6 T 21-04-2016 SPH21_RS22015 ce36e0de1bccb4f00bbbcb33154d0ee7 260 Pfam PF07978 NIPSNAP 157 259 1.3E-11 T 21-04-2016 IPR012577 NIPSNAP SPH21_RS22015 ce36e0de1bccb4f00bbbcb33154d0ee7 260 SUPERFAMILY SSF54909 34 144 2.68E-8 T 21-04-2016 IPR011008 Dimeric alpha-beta barrel SPH21_RS20405 6edc88521007ec9600696e2ce4848783 269 SUPERFAMILY SSF51735 5 263 8.47E-22 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS20405 6edc88521007ec9600696e2ce4848783 269 Gene3D G3DSA:3.40.50.720 2 222 9.0E-14 T 21-04-2016 IPR016040 NAD(P)-binding domain SPH21_RS00790 a79273e66ca65f0e38face770e07c16b 258 PANTHER PTHR33678 7 246 8.5E-63 T 21-04-2016 SPH21_RS00790 a79273e66ca65f0e38face770e07c16b 258 Pfam PF03050 Transposase IS66 family 4 203 2.7E-66 T 21-04-2016 IPR004291 Transposase, IS66 SPH21_RS00790 a79273e66ca65f0e38face770e07c16b 258 PANTHER PTHR33678:SF1 7 246 8.5E-63 T 21-04-2016 SPH21_RS03735 ece3db39c33fb4a7ec401e09d273c69c 347 PANTHER PTHR21716 1 337 2.9E-52 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS03735 ece3db39c33fb4a7ec401e09d273c69c 347 Pfam PF01594 Domain of unknown function DUF20 17 330 1.3E-39 T 21-04-2016 IPR002549 Transmembrane protein TqsA-like SPH21_RS03735 ece3db39c33fb4a7ec401e09d273c69c 347 PANTHER PTHR21716:SF13 1 337 2.9E-52 T 21-04-2016 SPH21_RS15765 5c5b2e1e0bf19b76a0d23e800e92d670 161 Gene3D G3DSA:1.20.1260.10 23 160 5.3E-5 T 21-04-2016 IPR012347 Ferritin-related SPH21_RS15765 5c5b2e1e0bf19b76a0d23e800e92d670 161 Pfam PF13628 Domain of unknown function (DUF4142) 30 160 1.4E-12 T 21-04-2016 IPR025419 Domain of unknown function DUF4142 SPH21_RS13715 b8cecf701b25f8f80c4670eb60260854 915 SUPERFAMILY SSF56935 749 825 8.7E-6 T 21-04-2016 SPH21_RS13715 b8cecf701b25f8f80c4670eb60260854 915 Gene3D G3DSA:2.170.130.10 751 817 2.1E-5 T 21-04-2016 IPR012910 TonB-dependent receptor, plug domain GO:0004872|GO:0006810|GO:0016020 SPH21_RS23890 c74a3cec507302294d2132dd244238ba 779 SUPERFAMILY SSF53300 325 486 3.89E-6 T 21-04-2016 IPR002035 von Willebrand factor, type A SPH21_RS21785 3c6a92939fee082bf575ee911059cab2 130 Pfam PF14087 Domain of unknown function (DUF4267) 17 122 2.2E-18 T 21-04-2016 IPR025363 Protein of unknown function DUF4267 SPH21_RS01765 882c18e5494bb71c65f7a7623a292055 162 SUPERFAMILY SSF55961 16 155 4.81E-21 T 21-04-2016 SPH21_RS02550 e63826429c4b152c3b2ed4f60e8242e3 358 Pfam PF06379 L-rhamnose-proton symport protein (RhaT) 4 353 8.8E-66 T 21-04-2016 IPR004673 L-rhamnose-proton symport, RhaT GO:0008645|GO:0015153|GO:0016021 SPH21_RS09020 9db9114f1f0b6c04d597dd54b0468e7b 277 Pfam PF01757 Acyltransferase family 1 265 1.9E-21 T 21-04-2016 IPR002656 Acyltransferase 3 GO:0016747 SPH21_RS05935 41a69890d86ce7a3879778f880929cc7 113 Pfam PF01934 Protein of unknown function DUF86 13 106 4.3E-24 T 21-04-2016 IPR008201 Protein of unknown function DUF86 SPH21_RS05935 41a69890d86ce7a3879778f880929cc7 113 PANTHER PTHR34139 1 113 1.6E-30 T 21-04-2016 SPH21_RS19970 4932546780d542052a61ee432c90fb89 202 Pfam PF14063 Protein of unknown function (DUF4254) 37 180 7.7E-65 T 21-04-2016 IPR025350 Protein of unknown function DUF4254 SPH21_RS09995 d75a0ec6551fce74555dbf221e897b20 378 Pfam PF07429 4-alpha-L-fucosyltransferase glycosyl transferase group 56 197 318 2.1E-9 T 21-04-2016 IPR009993 TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase GO:0008417|GO:0009246|GO:0036065 UniPathway: UPA00566 SPH21_RS24950 88347a7c6cfabc8a16af78f689abb405 178 Pfam PF13767 Domain of unknown function (DUF4168) 103 157 1.6E-7 T 21-04-2016 IPR025433 Domain of unknown function DUF4168 SPH21_RS24950 88347a7c6cfabc8a16af78f689abb405 178 Pfam PF13767 Domain of unknown function (DUF4168) 44 98 3.5E-8 T 21-04-2016 IPR025433 Domain of unknown function DUF4168 SPH21_RS09080 74aeb43834e26d951112561535ebdaca 294 Pfam PF16227 Domain of unknown function (DUF4886) 32 280 2.4E-105 T 21-04-2016 IPR032616 Domain of unknown function DUF4886 SPH21_RS10310 cf1e8038b1ce8de0c5fd1e3967c08913 335 Pfam PF11751 Protein of unknown function (DUF3308) 23 319 3.1E-76 T 21-04-2016 IPR019861 Type IX secretion system membrane protein, PorP/SprF family SPH21_RS10310 cf1e8038b1ce8de0c5fd1e3967c08913 335 TIGRFAM TIGR03519 T9SS_PorP_fam: type IX secretion system membrane protein, PorP/SprF family 9 322 4.0E-78 T 21-04-2016 IPR019861 Type IX secretion system membrane protein, PorP/SprF family SPH21_RS21570 1e80fb9d6a8686828014b5644914ebc7 118 Pfam PF14079 Domain of unknown function (DUF4260) 3 114 2.8E-46 T 21-04-2016 IPR025356 Protein of unknown function DUF4260 SPH21_RS02250 d42a2839b2068d1733e2223583ba5ca8 359 Pfam PF14486 Domain of unknown function (DUF4432) 33 341 3.7E-98 T 21-04-2016 IPR027839 Protein of unknown function DUF4432 SPH21_RS14915 1de47abca45026a7593b99c66186225b 212 Pfam PF14127 Domain of unknown function (DUF4294) 53 202 2.8E-56 T 21-04-2016 IPR025636 Protein of unknown function DUF4294 SPH21_RS19395 ad03567fc2f5cf1f1647cd6ce1ba62e1 328 SUPERFAMILY SSF56801 192 317 4.58E-6 T 21-04-2016 SPH21_RS19395 ad03567fc2f5cf1f1647cd6ce1ba62e1 328 Pfam PF04443 Acyl-protein synthetase, LuxE 17 326 4.1E-12 T 21-04-2016 IPR007534 Acyl-protein synthetase, LuxE GO:0008218|GO:0047474 MetaCyc: PWY-7723|UniPathway: UPA00569 SPH21_RS20980 64e0821165c7b5d51f457f6dd353db9a 155 Pfam PF04403 Paraquat-inducible protein A 35 99 2.6E-8 T 21-04-2016 IPR007498 Paraquat-inducible protein A SPH21_RS03280 b582e5b855c6c8c4489a8ac7d820bc53 244 Pfam PF02754 Cysteine-rich domain 3 84 2.5E-16 T 21-04-2016 IPR004017 Cysteine-rich domain SPH21_RS03280 b582e5b855c6c8c4489a8ac7d820bc53 244 Pfam PF02754 Cysteine-rich domain 127 221 6.7E-10 T 21-04-2016 IPR004017 Cysteine-rich domain SPH21_RS03280 b582e5b855c6c8c4489a8ac7d820bc53 244 PANTHER PTHR30296:SF0 2 244 3.9E-104 T 21-04-2016 SPH21_RS03280 b582e5b855c6c8c4489a8ac7d820bc53 244 PANTHER PTHR30296 2 244 3.9E-104 T 21-04-2016 SPH21_RS07010 6947b5d1dc7410c17dcae88667be97d0 227 Pfam PF14344 Domain of unknown function (DUF4397) 26 141 2.0E-13 T 21-04-2016 IPR025510 Domain of unknown function DUF4397 SPH21_RS22020 2c090e0da366023ef56cbe69bb9152ff 107 Gene3D G3DSA:3.10.450.50 5 104 5.7E-7 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS22020 2c090e0da366023ef56cbe69bb9152ff 107 SUPERFAMILY SSF54427 5 86 1.16E-10 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS08305 03ad086f18e6cff06be9ec5d2069ba19 202 Gene3D G3DSA:3.10.50.40 71 200 8.6E-12 T 21-04-2016 SPH21_RS08305 03ad086f18e6cff06be9ec5d2069ba19 202 SUPERFAMILY SSF54534 57 190 1.57E-8 T 21-04-2016 SPH21_RS03485 65f76d400401efe9293e0e0aa2a9e2a5 106 Pfam PF10825 Protein of unknown function (DUF2752) 25 72 5.6E-17 T 21-04-2016 IPR021215 Protein of unknown function DUF2752 SPH21_RS25715 4137ed45d15c67b767bb6dad9d0fb67b 184 Pfam PF13590 Domain of unknown function (DUF4136) 25 179 4.8E-28 T 21-04-2016 IPR025411 Domain of unknown function DUF4136 SPH21_RS22265 ee311b05ee532dd5c18e8a85dea01aa1 130 Gene3D G3DSA:1.10.10.60 9 46 1.7E-5 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS15085 a04dbf98d1ca516708045e10749a632a 143 Pfam PF04138 GtrA-like protein 19 133 6.0E-19 T 21-04-2016 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 SPH21_RS09880 87cfc208b9b7387590bc317b63c1baa3 244 PANTHER PTHR39181:SF1 18 213 3.3E-44 T 21-04-2016 SPH21_RS09880 87cfc208b9b7387590bc317b63c1baa3 244 SUPERFAMILY SSF89550 14 228 7.06E-15 T 21-04-2016 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 SPH21_RS09880 87cfc208b9b7387590bc317b63c1baa3 244 PIRSF PIRSF016557 17 244 1.8E-39 T 21-04-2016 IPR016667 Capsular polysaccharide synthesis, CpsB/CapC GO:0004725|GO:0030145 UniPathway: UPA00934 SPH21_RS09880 87cfc208b9b7387590bc317b63c1baa3 244 PANTHER PTHR39181 18 213 3.3E-44 T 21-04-2016 SPH21_RS24520 6adbf823f595051bbc4f49504b6fd615 714 Gene3D G3DSA:3.30.2010.10 105 194 1.3E-7 T 21-04-2016 SPH21_RS24520 6adbf823f595051bbc4f49504b6fd615 714 Pfam PF01435 Peptidase family M48 113 377 2.7E-12 T 21-04-2016 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SPH21_RS12420 e2ed8f6cb5b4ebbee0b34cea7a37dc1d 101 Pfam PF13648 Lipocalin-like domain 6 97 8.2E-5 T 21-04-2016 IPR024311 Lipocalin-like domain SPH21_RS09580 7a664d6be27def8b77880997c8350803 163 SUPERFAMILY SSF51182 71 146 3.83E-8 T 21-04-2016 IPR011051 RmlC-like cupin domain SPH21_RS09580 7a664d6be27def8b77880997c8350803 163 Gene3D G3DSA:2.60.120.10 70 132 1.1E-6 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS16170 61bf718079534f09ecbd3193363dc87a 531 PANTHER PTHR30047:SF2 7 512 2.1E-230 T 21-04-2016 SPH21_RS16170 61bf718079534f09ecbd3193363dc87a 531 PANTHER PTHR30047 7 512 2.1E-230 T 21-04-2016 SPH21_RS16170 61bf718079534f09ecbd3193363dc87a 531 Pfam PF02028 BCCT, betaine/carnitine/choline family transporter 15 496 5.8E-194 T 21-04-2016 IPR000060 BCCT transporter family GO:0005215|GO:0006810|GO:0016020 SPH21_RS16170 61bf718079534f09ecbd3193363dc87a 531 TIGRFAM TIGR00842 bcct: transporter, betaine/carnitine/choline transporter (BCCT) family 53 496 1.7E-160 T 21-04-2016 IPR000060 BCCT transporter family GO:0005215|GO:0006810|GO:0016020 SPH21_RS00985 1eba26d1d6cfc30671231b9428fae70e 170 Pfam PF10652 Protein of unknown function (DUF2480) 5 167 7.6E-48 T 21-04-2016 IPR018914 Protein of unknown function DUF2480 SPH21_RS02285 e19fbed31a30ae41fe5a32dce72b1858 245 Pfam PF06439 Domain of Unknown Function (DUF1080) 57 231 1.5E-29 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS17570 76b3c8a3002cad0af8bccc6ef814c381 141 Pfam PF05751 FixH 3 138 4.6E-17 T 21-04-2016 IPR008620 Nitrogen fixation protein FixH SPH21_RS07740 a3f67472a9a13fe788adee300e036fce 129 Pfam PF06170 Protein of unknown function (DUF983) 36 109 5.7E-5 T 21-04-2016 IPR009325 Protein of unknown function DUF983 SPH21_RS11775 8123ffee28b7819505909441b2d3af28 489 SUPERFAMILY SSF56601 155 472 3.18E-60 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS11775 8123ffee28b7819505909441b2d3af28 489 ProSitePatterns PS00336 Beta-lactamase class-C active site. 209 216 - T 21-04-2016 IPR001586 Beta-lactamase, class-C active site GO:0008800|GO:0017001|GO:0030288 KEGG: 00311+3.5.2.6 SPH21_RS11775 8123ffee28b7819505909441b2d3af28 489 PANTHER PTHR22935 157 469 3.9E-48 T 21-04-2016 SPH21_RS11775 8123ffee28b7819505909441b2d3af28 489 Pfam PF00144 Beta-lactamase 171 473 9.4E-43 T 21-04-2016 IPR001466 Beta-lactamase-related SPH21_RS11775 8123ffee28b7819505909441b2d3af28 489 Gene3D G3DSA:3.40.710.10 161 477 1.9E-64 T 21-04-2016 IPR012338 Beta-lactamase/transpeptidase-like SPH21_RS23950 75c91b84034f23aa3de4e0b5b85cd723 338 Pfam PF12294 Protein of unknown function (DUF3626) 113 301 1.8E-11 T 21-04-2016 IPR022074 Protein of unknown function DUF3626 SPH21_RS00470 fea8aa96c4afe2c5d27413eb4158d32c 449 Pfam PF04773 FecR protein 194 275 7.8E-6 T 21-04-2016 IPR006860 FecR protein SPH21_RS26170 131845d087a984cee2e01f40baf6142a 296 PANTHER PTHR22916 1 260 5.2E-43 T 21-04-2016 SPH21_RS26170 131845d087a984cee2e01f40baf6142a 296 Gene3D G3DSA:3.90.550.10 2 231 5.0E-49 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS26170 131845d087a984cee2e01f40baf6142a 296 Pfam PF00535 Glycosyl transferase family 2 3 132 7.5E-30 T 21-04-2016 IPR001173 Glycosyltransferase 2-like SPH21_RS26170 131845d087a984cee2e01f40baf6142a 296 SUPERFAMILY SSF53448 1 223 4.69E-51 T 21-04-2016 IPR029044 Nucleotide-diphospho-sugar transferases SPH21_RS25870 08285d1b1c70a221fa6658ca3a4dead1 394 Pfam PF07681 DoxX 15 101 9.8E-9 T 21-04-2016 IPR032808 DoxX family SPH21_RS00725 67eab3458400c8fa8271abdbe15865eb 446 Pfam PF04773 FecR protein 195 286 1.7E-4 T 21-04-2016 IPR006860 FecR protein SPH21_RS02805 d4d18ec76ce93ab6b95cb612d02262e9 67 TIGRFAM TIGR02537 arch_flag_Nterm: archaeal flagellin N-terminal-like domain 29 48 0.0027 T 21-04-2016 IPR013373 Flagellin/pilin, N-terminal SPH21_RS16065 67203002580585228f71ae46a1902c26 381 Pfam PF01103 Surface antigen 193 351 7.3E-9 T 21-04-2016 IPR000184 Bacterial surface antigen (D15) GO:0019867 SPH21_RS02700 22d4504430135cff89293ba50faa7dd7 77 Pfam PF11297 Protein of unknown function (DUF3098) 18 75 4.6E-16 T 21-04-2016 IPR021448 Protein of unknown function DUF3098 SPH21_RS17040 b78855d282b16c5b1bc18614b1853836 463 Pfam PF14092 Domain of unknown function (DUF4270) 47 462 1.6E-58 T 21-04-2016 IPR025366 Protein of unknown function DUF4270 SPH21_RS19800 ce185ab304d6cde36f1e5b445d9b9f33 456 Pfam PF06439 Domain of Unknown Function (DUF1080) 27 215 4.4E-42 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS19800 ce185ab304d6cde36f1e5b445d9b9f33 456 Pfam PF06439 Domain of Unknown Function (DUF1080) 246 454 1.1E-37 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS00820 92d591fcbf2ccd0d44a81f7b50a03a89 223 Pfam PF13320 Domain of unknown function (DUF4091) 113 171 2.9E-19 T 21-04-2016 IPR025150 Domain of unknown function DUF4091 SPH21_RS24640 e09000fa977f8d9d25cf76a8ac036a90 138 SUPERFAMILY SSF54427 27 124 2.87E-8 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS24640 e09000fa977f8d9d25cf76a8ac036a90 138 Gene3D G3DSA:3.10.450.50 55 124 1.8E-6 T 21-04-2016 IPR032710 NTF2-like domain SPH21_RS12790 7f6dce3108f37977c9fc35d2df1be34a 221 Pfam PF06439 Domain of Unknown Function (DUF1080) 61 217 2.2E-8 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS12310 5250cdbee71d872f5cc618c02911e40c 412 Pfam PF14298 Domain of unknown function (DUF4374) 32 194 2.1E-13 T 21-04-2016 IPR025401 Protein of unknown function DUF4374 SPH21_RS12310 5250cdbee71d872f5cc618c02911e40c 412 Pfam PF14298 Domain of unknown function (DUF4374) 209 399 2.0E-29 T 21-04-2016 IPR025401 Protein of unknown function DUF4374 SPH21_RS12190 f96228437d8e4c5d4f7184ab62edf3d2 153 Pfam PF13588 Type I restriction enzyme R protein N terminus (HSDR_N) 38 147 1.1E-36 T 21-04-2016 IPR029464 Type I restriction enzyme R protein, N-terminal domain SPH21_RS18075 872de953ce8deff6ed0b554f6ecfd777 896 SUPERFAMILY SSF56935 273 373 1.4E-6 T 21-04-2016 SPH21_RS18075 872de953ce8deff6ed0b554f6ecfd777 896 SUPERFAMILY SSF56935 139 246 1.4E-6 T 21-04-2016 SPH21_RS18075 872de953ce8deff6ed0b554f6ecfd777 896 SUPERFAMILY SSF56935 830 896 1.4E-6 T 21-04-2016 SPH21_RS18075 872de953ce8deff6ed0b554f6ecfd777 896 SUPERFAMILY SSF56935 416 791 1.4E-6 T 21-04-2016 SPH21_RS00045 468b4363c4620a5c127f7d18f78563ba 178 Pfam PF02620 Uncharacterized ACR, COG1399 59 175 1.0E-14 T 21-04-2016 IPR003772 Protein of unknown function DUF177 SPH21_RS11045 0f8d5b50a821733b33aefcc028420e11 188 Pfam PF01914 MarC family integral membrane protein 6 182 2.7E-31 T 21-04-2016 IPR002771 Multiple antibiotic resistance (MarC)-related GO:0016021 SPH21_RS11045 0f8d5b50a821733b33aefcc028420e11 188 PANTHER PTHR33508 1 185 4.0E-35 T 21-04-2016 SPH21_RS04265 4222a07a151edbc8eb0d7fd4086734f9 128 SUPERFAMILY SSF46785 65 114 1.41E-7 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS04265 4222a07a151edbc8eb0d7fd4086734f9 128 Gene3D G3DSA:1.10.10.10 65 113 6.4E-8 T 21-04-2016 IPR011991 Winged helix-turn-helix DNA-binding domain SPH21_RS01190 0bf6bc75e1d11549d53d9804dd29605c 371 Pfam PF12508 Protein of unknown function (DUF3714) 216 357 4.2E-39 T 21-04-2016 IPR022187 Conjugative transposon, TraM SPH21_RS22725 88fac4ca9614399fdfbdc9f85f5d9796 262 Pfam PF11459 Transcriptional regulator, AbiEi antitoxin, Type IV TA system 100 257 1.4E-56 T 21-04-2016 IPR021561 Transcriptional regulator, AbiEi_3 antitoxin, Type IV TA system SPH21_RS22725 88fac4ca9614399fdfbdc9f85f5d9796 262 Pfam PF17194 Transcriptional regulator, AbiEi antitoxin N-terminal domain 6 96 1.9E-29 T 21-04-2016 IPR033455 Transcriptional regulator AbiEi antitoxin, N-terminal domain SPH21_RS11915 02498d83e60fb7aee7705a238f3dd740 101 Pfam PF11950 Protein of unknown function (DUF3467) 3 83 3.6E-27 T 21-04-2016 IPR021857 Protein of unknown function DUF3467 SPH21_RS09620 c76d55eaf540e3e5b11eb43b0b51657a 386 SUPERFAMILY SSF53756 12 366 3.56E-20 T 21-04-2016 SPH21_RS09620 c76d55eaf540e3e5b11eb43b0b51657a 386 Pfam PF00534 Glycosyl transferases group 1 205 362 8.9E-12 T 21-04-2016 IPR001296 Glycosyl transferase, family 1 SPH21_RS08840 07a60e5c24ec0d9445d5895e4240fb5f 370 Pfam PF14897 EpsG family 29 359 1.2E-46 T 21-04-2016 SPH21_RS04060 88081b57738c1f68a53cd368da7df34e 368 PANTHER PTHR31061:SF1 47 368 4.8E-19 T 21-04-2016 SPH21_RS04060 88081b57738c1f68a53cd368da7df34e 368 PANTHER PTHR31061:SF1 3 29 4.8E-19 T 21-04-2016 SPH21_RS04060 88081b57738c1f68a53cd368da7df34e 368 PANTHER PTHR31061 47 368 4.8E-19 T 21-04-2016 SPH21_RS04060 88081b57738c1f68a53cd368da7df34e 368 PANTHER PTHR31061 3 29 4.8E-19 T 21-04-2016 SPH21_RS12470 1ed9191ca959d780e89227ad180657ae 228 Pfam PF12729 Four helix bundle sensory module for signal transduction 7 184 3.3E-29 T 21-04-2016 IPR024478 4HB MCP domain SPH21_RS00460 2c6f2bfeb76b2b91fb040297780ab8ee 179 Pfam PF07291 Methylamine utilisation protein MauE 24 122 2.8E-10 T 21-04-2016 IPR009908 Methylamine utilisation protein, MauE GO:0016021|GO:0030416 UniPathway: UPA00895 SPH21_RS20835 c89693f83c148b2cc1f406ad77a7786b 197 Pfam PF13505 Outer membrane protein beta-barrel domain 11 187 9.3E-10 T 21-04-2016 IPR027385 Outer membrane protein beta-barrel SPH21_RS20835 c89693f83c148b2cc1f406ad77a7786b 197 SUPERFAMILY SSF56925 32 194 6.28E-7 T 21-04-2016 IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel GO:0016021 SPH21_RS13030 11626bf7bd688315ebbcbc00d36cf2c5 79 SUPERFAMILY SSF55008 18 78 2.23E-7 T 21-04-2016 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SPH21_RS13030 11626bf7bd688315ebbcbc00d36cf2c5 79 Gene3D G3DSA:3.30.70.100 22 78 4.8E-7 T 21-04-2016 SPH21_RS14195 8f03a9add1db0416f910f5b03409b2f2 417 Pfam PF01566 Natural resistance-associated macrophage protein 49 389 4.9E-70 T 21-04-2016 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: REACT_15518 SPH21_RS18800 0e58cd9097b42b56b61f588d444b4d3b 208 SUPERFAMILY SSF160574 39 193 2.62E-11 T 21-04-2016 SPH21_RS24270 078410091a175ad9343a9b8393b3cd3e 382 Pfam PF12686 Protein of unknown function (DUF3800) 6 198 1.1E-27 T 21-04-2016 IPR024524 Protein of unknown function DUF3800 SPH21_RS14935 06c1e5f3cbf3a6da8edeb19c3707be0a 340 Pfam PF05893 Acyl-CoA reductase (LuxC) 80 163 4.1E-6 T 21-04-2016 IPR008670 Acyl-CoA reductase, LuxC GO:0003995|GO:0008218|GO:0055114 KEGG: 00073+1.2.1.50|MetaCyc: PWY-7723|UniPathway: UPA00569 SPH21_RS14935 06c1e5f3cbf3a6da8edeb19c3707be0a 340 SUPERFAMILY SSF53720 77 256 1.54E-5 T 21-04-2016 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SPH21_RS15570 e8b6e4836954d21a8195417d75aac8de 147 Pfam PF07681 DoxX 18 100 1.5E-9 T 21-04-2016 IPR032808 DoxX family SPH21_RS10230 d79d3da156370cad32507a528d2de46f 397 Pfam PF04230 Polysaccharide pyruvyl transferase 14 333 2.4E-23 T 21-04-2016 IPR007345 Polysaccharide pyruvyl transferase SPH21_RS02470 b7a12e74aebfa3c65c7cd82c0d32c655 369 Gene3D G3DSA:2.115.10.20 50 119 2.8E-4 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02470 b7a12e74aebfa3c65c7cd82c0d32c655 369 Gene3D G3DSA:2.115.10.20 143 322 2.3E-6 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS02470 b7a12e74aebfa3c65c7cd82c0d32c655 369 SUPERFAMILY SSF75005 61 283 1.21E-12 T 21-04-2016 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SPH21_RS26500 3ba7ba6a43858c77d653c4b4b94b075d 335 Pfam PF14093 Domain of unknown function (DUF4271) 130 333 3.5E-34 T 21-04-2016 IPR025367 Protein of unknown function DUF4271 SPH21_RS09625 1c93c18607ebe740b7a389bcc1501935 284 Pfam PF04230 Polysaccharide pyruvyl transferase 66 225 2.2E-13 T 21-04-2016 IPR007345 Polysaccharide pyruvyl transferase SPH21_RS01320 22d8845e974882dee148e5e176f90ec0 191 Gene3D G3DSA:2.60.120.10 6 160 6.0E-12 T 21-04-2016 IPR014710 RmlC-like jelly roll fold SPH21_RS01320 22d8845e974882dee148e5e176f90ec0 191 SUPERFAMILY SSF51206 28 138 7.46E-8 T 21-04-2016 IPR018490 Cyclic nucleotide-binding-like SPH21_RS02985 5494f37cfabd4e2a41d7c1001dbc1e42 225 Pfam PF12866 Protein of unknown function (DUF3823) 12 223 9.7E-59 T 21-04-2016 IPR024278 Protein of unknown function DUF3823 SPH21_RS07790 84743a5419e69c461116202f67ea2c52 346 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 35 331 6.8E-12 T 21-04-2016 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SPH21_RS12710 00f90f083cae697b5f52499159e300df 93 Pfam PF13453 Transcription factor zinc-finger 2 41 1.2E-19 T 21-04-2016 IPR027392 Transcription factor zinc-finger SPH21_RS22035 44975125e41e3aa77ee4700044c0d78e 160 SUPERFAMILY SSF55961 3 145 1.65E-12 T 21-04-2016 SPH21_RS14590 1dffee492efd31606bc3a7a1cc188d93 273 Pfam PF06439 Domain of Unknown Function (DUF1080) 35 265 7.6E-33 T 21-04-2016 IPR010496 Domain of unknown function DUF1080 SPH21_RS09450 3759865dcae53d66e775cffd36214c9d 160 Pfam PF13648 Lipocalin-like domain 57 138 2.2E-5 T 21-04-2016 IPR024311 Lipocalin-like domain SPH21_RS24575 293e0c9b7b6aef7045e8e7a8cf1034f6 223 Gene3D G3DSA:1.10.10.60 175 204 1.5E-4 T 21-04-2016 IPR009057 Homeodomain-like GO:0003677 SPH21_RS09170 c3212ec3a2a35b3985173bed845aa4fc 297 SMART SM00752 6 278 1.2E-4 T 21-04-2016 IPR011020 HTTM SPH21_RS01955 72a2b55e92c8dfd7df859d4056c665bb 300 Pfam PF16119 Domain of unknown function (DUF4835) 22 297 4.4E-101 T 21-04-2016 IPR032274 Protein of unknown function DUF4835 SPH21_RS26030 6fa6f0a7e5349b58f316365fd7f082d9 111 SUPERFAMILY SSF54534 2 69 4.52E-8 T 21-04-2016 SPH21_RS26030 6fa6f0a7e5349b58f316365fd7f082d9 111 Gene3D G3DSA:3.10.50.40 2 69 3.0E-4 T 21-04-2016 SPH21_RS17770 787bd5cd417e9616e2103aa41162cfb6 207 TIGRFAM TIGR03781 Bac_Flav_CT_K: Bacteroides conjugative transposon TraK protein 6 207 1.8E-104 T 21-04-2016 IPR022276 Conjugative transposon, TraK SPH21_RS09895 f9f18688cd4866a8f0909dd858ec858e 139 Pfam PF04892 VanZ like family 10 131 1.2E-21 T 21-04-2016 IPR006976 VanZ-like SPH21_RS06765 0d156ae3ea3b29be891de5c5d04b2781 135 Pfam PF13858 Protein of unknown function (DUF4199) 7 107 1.1E-12 T 21-04-2016 IPR025250 Protein of unknown function DUF4199 SPH21_RS14875 245230377a71e6784d3e96a70dda47fa 133 Pfam PF16022 Domain of unknown function (DUF4783) 28 130 1.9E-30 T 21-04-2016 IPR031977 Protein of unknown function DUF4783 SPH21_RS20545 7bed55ce18e405dcace1975faeef7c8b 273 Pfam PF14054 Domain of unknown function (DUF4249) 24 267 1.2E-36 T 21-04-2016 IPR025345 Protein of unknown function DUF4249 SPH21_RS02225 a0b58b935f57dd6110c22cb35c431edd 123 Pfam PF15071 Transmembrane family 220, helix 15 118 1.3E-24 T 21-04-2016 IPR029377 TMEM220 protein SPH21_RS19250 def6570402b18d1e47a759fd0324c816 218 Pfam PF14344 Domain of unknown function (DUF4397) 19 135 1.3E-18 T 21-04-2016 IPR025510 Domain of unknown function DUF4397 SPH21_RS08775 05dec58f626f8755d6bbba2c7b94b32a 161 Pfam PF16132 Domain of unknown function (DUF4843) 68 148 6.2E-8 T 21-04-2016 IPR032299 Protein of unknown function DUF4843 SPH21_RS03795 97dc3d15fb38bc359ef886a2584c7cde 341 Pfam PF11276 Protein of unknown function (DUF3078) 75 165 1.5E-22 T 21-04-2016 IPR021428 Protein of unknown function DUF3078 SPH21_RS18795 bf218db92c83b784d170c1133e69d96a 226 Pfam PF10677 Protein of unknown function (DUF2490) 31 206 8.7E-20 T 21-04-2016 IPR019619 Protein of unknown function DUF2490 SPH21_RS01270 b0812eda9a991b1abadb39d6468ec652 397 PANTHER PTHR34220 38 395 9.5E-35 T 21-04-2016 SPH21_RS01270 b0812eda9a991b1abadb39d6468ec652 397 Pfam PF06580 Histidine kinase 201 279 4.2E-20 T 21-04-2016 IPR010559 Signal transduction histidine kinase, internal region GO:0000155|GO:0000160|GO:0016021 SPH21_RS16960 4a8cb76591bc33b382e4374b9c9c6623 302 Pfam PF01040 UbiA prenyltransferase family 92 275 3.2E-11 T 21-04-2016 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SPH21_RS25865 10ecf74ea58a5375815835362f595100 186 Pfam PF07659 Domain of Unknown Function (DUF1599) 21 81 1.7E-27 T 21-04-2016 IPR011630 Clostridium phage phiCTP1, Gp74 SPH21_RS25865 10ecf74ea58a5375815835362f595100 186 Pfam PF07659 Domain of Unknown Function (DUF1599) 114 175 2.0E-25 T 21-04-2016 IPR011630 Clostridium phage phiCTP1, Gp74 SPH21_RS25075 e556a3ca296ac1cd92097247ffa0e644 124 Pfam PF13564 DoxX-like family 7 109 6.8E-8 T 21-04-2016 IPR032808 DoxX family SPH21_RS12125 30ff10e5583edd3d96a02e40dd780e7d 243 Pfam PF04338 Protein of unknown function, DUF481 49 227 7.9E-9 T 21-04-2016 IPR007433 Protein of unknown function DUF481 SPH21_RS06130 214d71c802b9b3f6e38895f9784af7d5 365 Pfam PF11199 Protein of unknown function (DUF2891) 43 361 1.5E-136 T 21-04-2016 IPR021365 Protein of unknown function DUF2891 SPH21_RS12075 9afcd7e714823969413d63556fc7760a 340 SUPERFAMILY SSF53756 7 231 1.35E-15 T 21-04-2016