locus-tag	class	description
GFH32_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFH32_RS00020	COG1663	tetraacyldisaccharide 4'-kinase activity
GFH32_RS00030	COG1774	PSP1 C-terminal conserved region
GFH32_RS00035	COG0470	DNA polymerase III
GFH32_RS00040	COG0592	DNA-directed DNA polymerase activity
GFH32_RS00045	COG0586	Pfam SNARE associated Golgi protein
GFH32_RS00050	COG0586	Pfam SNARE associated Golgi protein
GFH32_RS00060	COG1561	YicC-like family, N-terminal region
GFH32_RS00065	COG0194	GDP metabolic process
GFH32_RS00070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFH32_RS00080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GFH32_RS00090	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GFH32_RS00095	COG0653	protein targeting
GFH32_RS00105	COG1473	amidohydrolase
GFH32_RS00125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFH32_RS00130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFH32_RS00145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFH32_RS00150	COG0564	pseudouridine synthase activity
GFH32_RS00170	COG1278	Cold shock
GFH32_RS00175	COG1381	Involved in DNA repair and RecF pathway recombination
GFH32_RS00185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFH32_RS00190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFH32_RS00200	COG0552	protein localization to endoplasmic reticulum
GFH32_RS00205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH32_RS00210	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GFH32_RS00225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH32_RS00225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH32_RS00245	COG0494	nUDIX hydrolase
GFH32_RS00250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH32_RS00260	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS00295	COG4974	Belongs to the 'phage' integrase family
GFH32_RS00300	COG1629	transport
GFH32_RS00310	COG2323	membrane
GFH32_RS00345	COG3264	Mechanosensitive ion channel
GFH32_RS00345	COG1511	domain protein
GFH32_RS00365	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GFH32_RS00390	COG3685	Protein conserved in bacteria
GFH32_RS00395	COG1063	alcohol dehydrogenase
GFH32_RS00405	COG2801	Transposase and inactivated derivatives
GFH32_RS00420	COG4251	negative regulation of phosphorylation
GFH32_RS00445	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GFH32_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS00460	COG1595	DNA-templated transcription, initiation
GFH32_RS00470	COG2197	response regulator
GFH32_RS00495	COG2801	Transposase and inactivated derivatives
GFH32_RS00525	COG1196	nuclear chromosome segregation
GFH32_RS00555	COG2963	transposase activity
GFH32_RS00570	COG0702	epimerase
GFH32_RS00595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFH32_RS00600	COG1115	amino acid carrier protein
GFH32_RS00625	COG1278	Cold shock
GFH32_RS00635	COG0513	Belongs to the DEAD box helicase family
GFH32_RS00640	COG1278	Cold shock
GFH32_RS00645	COG4771	TonB-dependent receptor
GFH32_RS00650	COG0702	epimerase
GFH32_RS00695	COG0673	inositol 2-dehydrogenase activity
GFH32_RS00750	COG0702	epimerase
GFH32_RS00755	COG4771	TonB-dependent receptor
GFH32_RS00765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH32_RS00775	COG0657	acetylesterase activity
GFH32_RS00775	COG2755	lipolytic protein G-D-S-L family
GFH32_RS00780	COG2271	Major facilitator Superfamily
GFH32_RS00790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH32_RS00800	COG1629	transport
GFH32_RS00805	COG2186	Transcriptional regulator
GFH32_RS00815	COG0702	epimerase
GFH32_RS00820	COG4771	TonB-dependent receptor
GFH32_RS00825	COG2188	Transcriptional regulator
GFH32_RS00830	COG1629	transport
GFH32_RS00850	COG1629	transport
GFH32_RS00850	COG4206	TonB-dependent receptor
GFH32_RS00865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH32_RS00910	COG4206	TonB-dependent receptor
GFH32_RS00910	COG1629	transport
GFH32_RS00940	COG1609	Transcriptional regulator
GFH32_RS00955	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GFH32_RS00960	COG2819	hydrolase of the alpha beta superfamily
GFH32_RS00980	COG1629	transport
GFH32_RS00980	COG4206	TonB-dependent receptor
GFH32_RS00985	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH32_RS00995	COG0366	Alpha amylase catalytic
GFH32_RS01000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH32_RS01040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFH32_RS01050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFH32_RS01080	COG1904	glucuronate isomerase
GFH32_RS01090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS01095	COG0363	glucosamine-6-phosphate deaminase activity
GFH32_RS01115	COG4774	siderophore transport
GFH32_RS01135	COG0156	8-amino-7-oxononanoate synthase activity
GFH32_RS01140	COG1217	gtp-binding protein TYPA
GFH32_RS01155	COG4574	serine-type endopeptidase inhibitor activity
GFH32_RS01170	COG0339	signal peptide processing
GFH32_RS01180	COG1132	(ABC) transporter
GFH32_RS01185	COG0101	tRNA pseudouridine synthase activity
GFH32_RS01205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFH32_RS01215	COG1522	sequence-specific DNA binding
GFH32_RS01220	COG0719	Fe-S assembly protein
GFH32_RS01225	COG0396	ATPase activity
GFH32_RS01230	COG0719	Fe-S assembly protein
GFH32_RS01240	COG1629	transport
GFH32_RS01255	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GFH32_RS01275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS01285	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GFH32_RS01310	COG1570	exodeoxyribonuclease VII activity
GFH32_RS01315	COG1722	exodeoxyribonuclease VII activity
GFH32_RS01320	COG1595	DNA-templated transcription, initiation
GFH32_RS01330	COG4771	TonB-dependent receptor
GFH32_RS01340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS01345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS01350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFH32_RS01360	COG1959	2 iron, 2 sulfur cluster binding
GFH32_RS01365	COG0346	lactoylglutathione lyase activity
GFH32_RS01370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFH32_RS01380	COG0205	6-phosphofructokinase activity
GFH32_RS01385	COG4232	protein-disulfide reductase activity
GFH32_RS01395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GFH32_RS01395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GFH32_RS01400	COG0799	negative regulation of ribosome biogenesis
GFH32_RS01405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH32_RS01410	COG1556	Lactate utilization protein
GFH32_RS01465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH32_RS01470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFH32_RS01485	COG4771	TonB-dependent receptor
GFH32_RS01495	COG0673	inositol 2-dehydrogenase activity
GFH32_RS01500	COG1082	Xylose isomerase domain protein TIM barrel
GFH32_RS01530	COG1054	Belongs to the UPF0176 family
GFH32_RS01535	COG3530	Putative quorum-sensing-regulated virulence factor
GFH32_RS01575	COG1349	DNA-binding transcription factor activity
GFH32_RS01585	COG0217	transcriptional regulatory protein
GFH32_RS01590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH32_RS01595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFH32_RS01620	COG1335	isochorismatase
GFH32_RS01630	COG1309	transcriptional regulator
GFH32_RS01635	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH32_RS01640	COG1760	l-serine dehydratase
GFH32_RS01645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFH32_RS01660	COG4771	TonB-dependent receptor
GFH32_RS01680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS01685	COG0321	lipoyl(octanoyl) transferase activity
GFH32_RS01690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFH32_RS01695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFH32_RS01700	COG0251	oxidation-reduction process
GFH32_RS01705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GFH32_RS01710	COG1649	PFAM Uncharacterised BCR, COG1649
GFH32_RS01715	COG3876	Protein conserved in bacteria
GFH32_RS01720	COG1629	transport
GFH32_RS01730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GFH32_RS01735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFH32_RS01740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH32_RS01780	COG1192	Involved in chromosome partitioning
GFH32_RS01785	COG1475	DNA binding
GFH32_RS01795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFH32_RS01800	COG0681	Belongs to the peptidase S26 family
GFH32_RS01805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GFH32_RS01820	COG0277	FAD linked oxidase domain protein
GFH32_RS01820	COG0247	lactate metabolic process
GFH32_RS01845	COG3852	Histidine kinase
GFH32_RS01850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFH32_RS01860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH32_RS01865	COG1629	transport
GFH32_RS01870	COG0702	epimerase
GFH32_RS01885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFH32_RS01895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH32_RS01910	COG0708	Exodeoxyribonuclease III
GFH32_RS01915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFH32_RS01920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFH32_RS01940	COG1960	acyl-CoA dehydrogenase activity
GFH32_RS01945	COG0450	alkyl hydroperoxide reductase
GFH32_RS01955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH32_RS01995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFH32_RS02000	COG2076	Multidrug Resistance protein
GFH32_RS02005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH32_RS02010	COG1505	serine-type exopeptidase activity
GFH32_RS02020	COG3579	cysteine-type endopeptidase activity
GFH32_RS02030	COG0142	geranyltranstransferase activity
GFH32_RS02050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFH32_RS02075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFH32_RS02090	COG1132	(ABC) transporter
GFH32_RS02110	COG1702	phosphate starvation-inducible protein PhoH
GFH32_RS02115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFH32_RS02125	COG1234	tRNA 3'-trailer cleavage
GFH32_RS02130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH32_RS02135	COG0131	Imidazoleglycerol-phosphate dehydratase
GFH32_RS02145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFH32_RS02150	COG0107	imidazoleglycerol-phosphate synthase activity
GFH32_RS02155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFH32_RS02155	COG0140	phosphoribosyl-ATP diphosphatase activity
GFH32_RS02170	COG1956	GAF domain-containing protein
GFH32_RS02175	COG0632	four-way junction helicase activity
GFH32_RS02180	COG0280	phosphate acetyltransferase
GFH32_RS02180	COG0281	malic enzyme
GFH32_RS02190	COG0006	proline dipeptidase activity
GFH32_RS02195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFH32_RS02205	COG1940	carbohydrate kinase activity
GFH32_RS02210	COG4206	TonB-dependent receptor
GFH32_RS02210	COG1629	transport
GFH32_RS02225	COG1185	polyribonucleotide nucleotidyltransferase activity
GFH32_RS02240	COG3537	Alpha-1,2-mannosidase
GFH32_RS02245	COG1609	Transcriptional regulator
GFH32_RS02260	COG0437	4 iron, 4 sulfur cluster binding
GFH32_RS02285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFH32_RS02290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFH32_RS02295	COG1612	heme a metabolic process
GFH32_RS02300	COG0109	protoheme IX farnesyltransferase activity
GFH32_RS02305	COG1845	cytochrome c oxidase, subunit III
GFH32_RS02305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFH32_RS02310	COG1845	cytochrome c oxidase, subunit III
GFH32_RS02325	COG2322	membrane
GFH32_RS02335	COG2259	Doxx family
GFH32_RS02340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH32_RS02340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH32_RS02345	COG1114	Component of the transport system for branched-chain amino acids
GFH32_RS02350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFH32_RS02360	COG0009	L-threonylcarbamoyladenylate synthase
GFH32_RS02365	COG2171	N-acyltransferase activity
GFH32_RS02370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFH32_RS02380	COG4771	TonB-dependent receptor
GFH32_RS02385	COG0702	epimerase
GFH32_RS02405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH32_RS02410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFH32_RS02415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GFH32_RS02440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GFH32_RS02460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH32_RS02460	COG0758	DNA mediated transformation
GFH32_RS02470	COG0357	Ribosomal RNA small subunit methyltransferase G
GFH32_RS02475	COG1215	transferase activity, transferring glycosyl groups
GFH32_RS02480	COG0343	queuine tRNA-ribosyltransferase activity
GFH32_RS02495	COG1160	GTP binding
GFH32_RS02500	COG0215	cysteine-tRNA ligase activity
GFH32_RS02515	COG2706	6-phosphogluconolactonase activity
GFH32_RS02520	COG1320	monovalent cation:proton antiporter activity
GFH32_RS02525	COG2212	antiporter activity
GFH32_RS02530	COG1863	multisubunit Na H antiporter MnhE subunit
GFH32_RS02535	COG0651	ATP synthesis coupled electron transport
GFH32_RS02540	COG1006	Multisubunit Na H antiporter MnhC subunit
GFH32_RS02545	COG2111	Na H antiporter
GFH32_RS02550	COG2111	Na H antiporter
GFH32_RS02550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH32_RS02560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFH32_RS02570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH32_RS02580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFH32_RS02585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GFH32_RS02590	COG0617	tRNA 3'-terminal CCA addition
GFH32_RS02590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFH32_RS02590	COG0517	IMP dehydrogenase activity
GFH32_RS02600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFH32_RS02605	COG3250	beta-galactosidase activity
GFH32_RS02625	COG1629	transport
GFH32_RS02625	COG4206	TonB-dependent receptor
GFH32_RS02640	COG1137	ATPase activity
GFH32_RS02645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFH32_RS02645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFH32_RS02655	COG0490	domain, Protein
GFH32_RS02660	COG0475	glutathione-regulated potassium exporter activity
GFH32_RS02665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFH32_RS02685	COG0069	glutamate synthase activity
GFH32_RS02685	COG0067	glutamate synthase
GFH32_RS02685	COG0070	glutamate synthase
GFH32_RS02690	COG4948	Mandelate Racemase Muconate Lactonizing
GFH32_RS02705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFH32_RS02715	COG0037	tRNA processing
GFH32_RS02730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFH32_RS02740	COG2962	Rard protein
GFH32_RS02760	COG0009	L-threonylcarbamoyladenylate synthase
GFH32_RS02765	COG0017	Asparaginyl-tRNA synthetase
GFH32_RS02770	COG0113	porphobilinogen synthase activity
GFH32_RS02775	COG0181	hydroxymethylbilane synthase activity
GFH32_RS02780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFH32_RS02805	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GFH32_RS02810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFH32_RS02815	COG0165	Argininosuccinate lyase
GFH32_RS02830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GFH32_RS02855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFH32_RS02865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH32_RS02880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH32_RS02890	COG2205	protein histidine kinase activity
GFH32_RS02890	COG0784	Response regulator, receiver
GFH32_RS02900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GFH32_RS02905	COG0784	Response regulator, receiver
GFH32_RS02905	COG2205	protein histidine kinase activity
GFH32_RS02915	COG4864	UPF0365 protein
GFH32_RS02920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GFH32_RS02925	COG0424	maF-like protein
GFH32_RS02940	COG0159	tryptophan synthase activity
GFH32_RS02945	COG0133	tryptophan synthase activity
GFH32_RS02950	COG0135	phosphoribosylanthranilate isomerase activity
GFH32_RS02955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFH32_RS02995	COG3591	Belongs to the peptidase S1B family
GFH32_RS03000	COG0513	Belongs to the DEAD box helicase family
GFH32_RS03025	COG3275	phosphorelay sensor kinase activity
GFH32_RS03030	COG1607	acyl-coa hydrolase
GFH32_RS03040	COG2234	aminopeptidase activity
GFH32_RS03040	COG4935	Belongs to the peptidase S8 family
GFH32_RS03045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFH32_RS03050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GFH32_RS03055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFH32_RS03070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFH32_RS03075	COG1595	DNA-templated transcription, initiation
GFH32_RS03210	COG1278	Cold shock
GFH32_RS03230	COG3237	CsbD-like
GFH32_RS03235	COG3685	Protein conserved in bacteria
GFH32_RS03240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFH32_RS03330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFH32_RS03335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS03340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS03345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFH32_RS03350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFH32_RS03365	COG0233	cytoplasmic translational termination
GFH32_RS03370	COG0528	UMP kinase activity
GFH32_RS03375	COG0438	transferase activity, transferring glycosyl groups
GFH32_RS03380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFH32_RS03415	COG0484	heat shock protein binding
GFH32_RS03420	COG1528	Iron-storage protein
GFH32_RS03440	COG1131	(ABC) transporter
GFH32_RS03445	COG2234	aminopeptidase activity
GFH32_RS03450	COG0698	ribose 5-phosphate isomerase
GFH32_RS03455	COG0805	protein transport
GFH32_RS03460	COG0439	Biotin carboxylase
GFH32_RS03470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH32_RS03475	COG0416	fatty acid biosynthetic process
GFH32_RS03480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFH32_RS03490	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFH32_RS03515	COG0577	efflux transmembrane transporter activity
GFH32_RS03525	COG0577	efflux transmembrane transporter activity
GFH32_RS03530	COG0577	efflux transmembrane transporter activity
GFH32_RS03530	COG1136	(ABC) transporter
GFH32_RS03535	COG1136	(ABC) transporter
GFH32_RS03550	COG2204	response regulator
GFH32_RS03555	COG3852	Histidine kinase
GFH32_RS03610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFH32_RS03615	COG0081	regulation of translation
GFH32_RS03620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFH32_RS03625	COG0222	ribosome binding
GFH32_RS03630	COG0085	RNA polymerase activity
GFH32_RS03635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFH32_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS03660	COG1312	Catalyzes the dehydration of D-mannonate
GFH32_RS03670	COG1674	ftsk spoiiie
GFH32_RS03680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFH32_RS03690	COG0531	amino acid
GFH32_RS03700	COG3158	transport of potassium into the cell
GFH32_RS03725	COG0193	aminoacyl-tRNA hydrolase activity
GFH32_RS03730	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GFH32_RS03745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFH32_RS03750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFH32_RS03765	COG2801	Transposase and inactivated derivatives
GFH32_RS03785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFH32_RS03790	COG0540	Belongs to the ATCase OTCase family
GFH32_RS03810	COG0811	peptide transport
GFH32_RS03825	COG0285	dihydrofolate synthase activity
GFH32_RS03830	COG0252	asparaginase activity
GFH32_RS03835	COG0084	hydrolase, TatD family'
GFH32_RS03840	COG0545	Peptidyl-prolyl cis-trans isomerase
GFH32_RS03845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFH32_RS03855	COG2363	Small membrane protein
GFH32_RS03865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFH32_RS03875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GFH32_RS03885	COG1607	acyl-coa hydrolase
GFH32_RS03900	COG1012	belongs to the aldehyde dehydrogenase family
GFH32_RS03905	COG2207	Transcriptional regulator
GFH32_RS03905	COG1609	Transcriptional regulator
GFH32_RS03910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFH32_RS03915	COG0156	8-amino-7-oxononanoate synthase activity
GFH32_RS03920	COG0456	acetyltransferase
GFH32_RS03925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH32_RS03970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH32_RS04015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFH32_RS04025	COG0268	Binds directly to 16S ribosomal RNA
GFH32_RS04040	COG0427	acetyl-CoA hydrolase
GFH32_RS04065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFH32_RS04090	COG1045	serine acetyltransferase
GFH32_RS04110	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFH32_RS04135	COG4452	Inner membrane protein CreD
GFH32_RS04140	COG0823	Involved in the tonB-independent uptake of proteins
GFH32_RS04140	COG1506	peptidase
GFH32_RS04150	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFH32_RS04155	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFH32_RS04160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GFH32_RS04165	COG1058	Belongs to the CinA family
GFH32_RS04165	COG1546	Belongs to the CinA family
GFH32_RS04170	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH32_RS04185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFH32_RS04190	COG2183	response to ionizing radiation
GFH32_RS04195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GFH32_RS04210	COG1960	acyl-CoA dehydrogenase activity
GFH32_RS04215	COG0706	membrane insertase activity
GFH32_RS04220	COG0504	CTP synthase activity
GFH32_RS04225	COG0667	Aldo Keto reductase
GFH32_RS04230	COG0335	large ribosomal subunit rRNA binding
GFH32_RS04265	COG3119	arylsulfatase activity
GFH32_RS04280	COG1629	transport
GFH32_RS04280	COG4206	TonB-dependent receptor
GFH32_RS04295	COG3119	arylsulfatase activity
GFH32_RS04300	COG3119	arylsulfatase activity
GFH32_RS04305	COG3119	arylsulfatase activity
GFH32_RS04310	COG0702	epimerase
GFH32_RS04315	COG4771	TonB-dependent receptor
GFH32_RS04330	COG0587	DNA-directed DNA polymerase activity
GFH32_RS04350	COG1131	(ABC) transporter
GFH32_RS04355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH32_RS04360	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFH32_RS04390	COG1073	alpha beta
GFH32_RS04405	COG4771	TonB-dependent receptor
GFH32_RS04410	COG4948	Mandelate Racemase Muconate Lactonizing
GFH32_RS04415	COG0791	NLP P60 protein
GFH32_RS04420	COG1446	asparaginase
GFH32_RS04425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH32_RS04440	COG4771	TonB-dependent receptor
GFH32_RS04450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS04465	COG0438	transferase activity, transferring glycosyl groups
GFH32_RS04475	COG0438	transferase activity, transferring glycosyl groups
GFH32_RS04475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFH32_RS04490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFH32_RS04505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH32_RS04510	COG2814	Major facilitator Superfamily
GFH32_RS04515	COG0628	permease
GFH32_RS04525	COG2986	histidine ammonia-lyase
GFH32_RS04530	COG1228	amidohydrolase
GFH32_RS04535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFH32_RS04545	COG1741	Belongs to the pirin family
GFH32_RS04555	COG2183	response to ionizing radiation
GFH32_RS04555	COG0539	negative regulation of cytoplasmic translation
GFH32_RS04560	COG2205	protein histidine kinase activity
GFH32_RS04560	COG0784	Response regulator, receiver
GFH32_RS04565	COG1295	ribonuclease BN
GFH32_RS04570	COG0824	Thioesterase
GFH32_RS04575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFH32_RS04585	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFH32_RS04600	COG0386	Belongs to the glutathione peroxidase family
GFH32_RS04605	COG1435	thymidine kinase activity
GFH32_RS04620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFH32_RS04625	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFH32_RS04645	COG1183	phosphatidylcholine synthase activity
GFH32_RS04660	COG0616	signal peptide processing
GFH32_RS04665	COG0126	phosphoglycerate kinase activity
GFH32_RS04675	COG2239	Acts as a magnesium transporter
GFH32_RS04690	COG0583	DNA-binding transcription factor activity
GFH32_RS04705	COG1595	DNA-templated transcription, initiation
GFH32_RS04710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFH32_RS04715	COG1309	transcriptional regulator
GFH32_RS04720	COG0492	ferredoxin-NADP+ reductase activity
GFH32_RS04725	COG1289	transmembrane transporter activity
GFH32_RS04730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFH32_RS04740	COG0673	inositol 2-dehydrogenase activity
GFH32_RS04755	COG0247	lactate metabolic process
GFH32_RS04755	COG2181	nitrate reductase activity
GFH32_RS04760	COG0247	lactate metabolic process
GFH32_RS04760	COG2181	nitrate reductase activity
GFH32_RS04785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFH32_RS04790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFH32_RS04815	COG1610	YqeY-like protein
GFH32_RS04820	COG4221	oxidoreductase activity
GFH32_RS04825	COG2226	methyltransferase
GFH32_RS04830	COG0305	Participates in initiation and elongation during chromosome replication
GFH32_RS04845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFH32_RS04850	COG2353	YceI-like domain
GFH32_RS04855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GFH32_RS04870	COG0022	dehydrogenase e1 component
GFH32_RS04880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFH32_RS04890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFH32_RS04895	COG1605	Chorismate mutase
GFH32_RS04895	COG0077	Prephenate dehydratase
GFH32_RS04900	COG0697	spore germination
GFH32_RS04905	COG1739	Uncharacterized protein family UPF0029
GFH32_RS04915	COG0772	Belongs to the SEDS family
GFH32_RS04935	COG1077	Cell shape determining protein MreB Mrl
GFH32_RS04945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFH32_RS04945	COG1796	DNA polymerase
GFH32_RS04950	COG1252	NADH dehydrogenase
GFH32_RS04960	COG0492	ferredoxin-NADP+ reductase activity
GFH32_RS04975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFH32_RS04980	COG2166	iron-sulfur cluster assembly
GFH32_RS04985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFH32_RS05000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFH32_RS05005	COG2814	Major facilitator Superfamily
GFH32_RS05010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFH32_RS05015	COG1363	Peptidase, m42
GFH32_RS05030	COG3153	acetyltransferase
GFH32_RS05030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH32_RS05050	COG1309	transcriptional regulator
GFH32_RS05070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFH32_RS05080	COG0525	valine-tRNA ligase activity
GFH32_RS05085	COG1368	sulfuric ester hydrolase activity
GFH32_RS05090	COG1368	sulfuric ester hydrolase activity
GFH32_RS05110	COG0415	Belongs to the DNA photolyase family
GFH32_RS05125	COG0367	asparagine synthase
GFH32_RS05135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH32_RS05140	COG1522	sequence-specific DNA binding
GFH32_RS05150	COG4251	negative regulation of phosphorylation
GFH32_RS05160	COG1113	amino acid transport
GFH32_RS05190	COG0671	phosphoesterase, PA-phosphatase related
GFH32_RS05195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH32_RS05210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFH32_RS05215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFH32_RS05245	COG1132	(ABC) transporter
GFH32_RS05255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFH32_RS05300	COG0237	dephospho-CoA kinase activity
GFH32_RS05320	COG0482	sulfurtransferase activity
GFH32_RS05325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFH32_RS05335	COG0205	6-phosphofructokinase activity
GFH32_RS05370	COG5006	permease, DMT superfamily
GFH32_RS05380	COG1295	ribonuclease BN
GFH32_RS05385	COG0189	ligase activity
GFH32_RS05405	COG2197	response regulator
GFH32_RS05410	COG2132	Multicopper oxidase
GFH32_RS05450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFH32_RS05455	COG2003	Belongs to the UPF0758 family
GFH32_RS05460	COG1741	Belongs to the pirin family
GFH32_RS05470	COG2885	chlorophyll binding
GFH32_RS05480	COG3040	lipid binding
GFH32_RS05505	COG3590	peptidase
GFH32_RS05510	COG3422	double-strand break repair
GFH32_RS05515	COG3012	SEC-C Motif Domain Protein
GFH32_RS05525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFH32_RS05550	COG2814	Major facilitator Superfamily
GFH32_RS05555	COG2217	Heavy metal translocating P-type atpase
GFH32_RS05565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFH32_RS05575	COG0284	orotidine-5'-phosphate decarboxylase activity
GFH32_RS05600	COG0515	serine threonine protein kinase
GFH32_RS05600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFH32_RS05605	COG0673	inositol 2-dehydrogenase activity
GFH32_RS05620	COG2211	Major facilitator Superfamily
GFH32_RS05630	COG0673	inositol 2-dehydrogenase activity
GFH32_RS05655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFH32_RS05655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GFH32_RS05660	COG0328	RNA-DNA hybrid ribonuclease activity
GFH32_RS05670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFH32_RS05705	COG1166	arginine decarboxylase activity
GFH32_RS05710	COG0018	arginyl-trna synthetase
GFH32_RS05715	COG0673	inositol 2-dehydrogenase activity
GFH32_RS05720	COG2081	HI0933 family
GFH32_RS05745	COG0460	homoserine dehydrogenase
GFH32_RS05750	COG2873	o-acetylhomoserine
GFH32_RS05760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH32_RS05765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH32_RS05770	COG1216	Glycosyl transferase, family 2
GFH32_RS05790	COG0110	maltose O-acetyltransferase activity
GFH32_RS05810	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFH32_RS05815	COG2267	carboxylic ester hydrolase activity
GFH32_RS05830	COG0563	adenylate kinase activity
GFH32_RS05835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFH32_RS05850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFH32_RS05860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFH32_RS05870	COG0517	IMP dehydrogenase activity
GFH32_RS05870	COG0516	GMP reductase activity
GFH32_RS05875	COG0662	Cupin 2, conserved barrel domain protein
GFH32_RS05875	COG2207	Transcriptional regulator
GFH32_RS05880	COG0738	Major facilitator superfamily
GFH32_RS05890	COG2721	sulfolactate sulfo-lyase activity
GFH32_RS05895	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS05900	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH32_RS05910	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS05920	COG4771	TonB-dependent receptor
GFH32_RS05925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFH32_RS05930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GFH32_RS05955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH32_RS05965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFH32_RS05970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFH32_RS05975	COG2022	thiamine diphosphate biosynthetic process
GFH32_RS05980	COG0352	thiamine-phosphate diphosphorylase activity
GFH32_RS05985	COG0352	thiamine-phosphate diphosphorylase activity
GFH32_RS06015	COG0387	Pfam Sodium calcium exchanger
GFH32_RS06045	COG1629	transport
GFH32_RS06050	COG0702	epimerase
GFH32_RS06065	COG2271	Major facilitator Superfamily
GFH32_RS06075	COG4948	Mandelate Racemase Muconate Lactonizing
GFH32_RS06080	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS06085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GFH32_RS06085	COG0473	3-isopropylmalate dehydrogenase activity
GFH32_RS06090	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GFH32_RS06115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFH32_RS06135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH32_RS06140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH32_RS06155	COG0824	Thioesterase
GFH32_RS06160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFH32_RS06170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH32_RS06175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH32_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS06185	COG2986	histidine ammonia-lyase
GFH32_RS06190	COG0492	ferredoxin-NADP+ reductase activity
GFH32_RS06215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GFH32_RS06220	COG0673	inositol 2-dehydrogenase activity
GFH32_RS06230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH32_RS06235	COG4771	TonB-dependent receptor
GFH32_RS06260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH32_RS06265	COG1595	DNA-templated transcription, initiation
GFH32_RS06275	COG4771	TonB-dependent receptor
GFH32_RS06280	COG0702	epimerase
GFH32_RS06285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH32_RS06310	COG1629	transport
GFH32_RS06315	COG0702	epimerase
GFH32_RS06330	COG4206	TonB-dependent receptor
GFH32_RS06330	COG1629	transport
GFH32_RS06335	COG0702	epimerase
GFH32_RS06365	COG1629	transport
GFH32_RS06400	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH32_RS06405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH32_RS06405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH32_RS06420	COG1609	Transcriptional regulator
GFH32_RS06425	COG0163	prenyltransferase activity
GFH32_RS06430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH32_RS06445	COG0463	Glycosyl transferase, family 2
GFH32_RS06450	COG1216	Glycosyl transferase, family 2
GFH32_RS06450	COG0463	Glycosyl transferase, family 2
GFH32_RS06460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFH32_RS06460	COG0321	lipoyl(octanoyl) transferase activity
GFH32_RS06475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFH32_RS06485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFH32_RS06490	COG0297	glycogen (starch) synthase activity
GFH32_RS06495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFH32_RS06500	COG0697	spore germination
GFH32_RS06510	COG0247	lactate metabolic process
GFH32_RS06510	COG0277	FAD linked oxidase domain protein
GFH32_RS06550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFH32_RS06555	COG1253	flavin adenine dinucleotide binding
GFH32_RS06565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GFH32_RS06580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GFH32_RS06590	COG1131	(ABC) transporter
GFH32_RS06605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH32_RS06615	COG0488	(ABC) transporter
GFH32_RS06635	COG1115	amino acid carrier protein
GFH32_RS06650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFH32_RS06685	COG0492	ferredoxin-NADP+ reductase activity
GFH32_RS06690	COG0561	phosphatase activity
GFH32_RS06715	COG1418	mRNA catabolic process
GFH32_RS06745	COG1609	Transcriptional regulator
GFH32_RS06750	COG1132	(ABC) transporter
GFH32_RS06755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFH32_RS06770	COG2363	Small membrane protein
GFH32_RS06775	COG3118	belongs to the thioredoxin family
GFH32_RS06780	COG2824	Alkylphosphonate utilization operon protein PhnA
GFH32_RS06785	COG2321	neutral zinc metallopeptidase
GFH32_RS06805	COG0579	oxidoreductase
GFH32_RS06830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH32_RS06840	COG0527	aspartate kinase activity
GFH32_RS06855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFH32_RS06865	COG1193	negative regulation of DNA recombination
GFH32_RS06885	COG1611	Belongs to the LOG family
GFH32_RS06890	COG0673	inositol 2-dehydrogenase activity
GFH32_RS06895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFH32_RS06900	COG0657	acetylesterase activity
GFH32_RS06900	COG2755	lipolytic protein G-D-S-L family
GFH32_RS06910	COG0737	Belongs to the 5'-nucleotidase family
GFH32_RS06915	COG0737	Belongs to the 5'-nucleotidase family
GFH32_RS06920	COG1940	carbohydrate kinase activity
GFH32_RS06920	COG1846	Transcriptional regulator
GFH32_RS06925	COG2133	pyrroloquinoline quinone binding
GFH32_RS06930	COG1678	Uncharacterized ACR, COG1678
GFH32_RS06935	COG0259	pyridoxamine-phosphate oxidase activity
GFH32_RS06940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS06945	COG0649	NAD binding
GFH32_RS06955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH32_RS06965	COG1538	Outer membrane efflux protein
GFH32_RS06975	COG2910	NAD(P)H-binding
GFH32_RS06990	COG1393	Belongs to the ArsC family
GFH32_RS06995	COG0191	fructose-bisphosphate aldolase activity
GFH32_RS07000	COG4974	Belongs to the 'phage' integrase family
GFH32_RS07015	COG1528	Iron-storage protein
GFH32_RS07025	COG3321	synthase
GFH32_RS07025	COG0604	alcohol dehydrogenase
GFH32_RS07030	COG3537	Alpha-1,2-mannosidase
GFH32_RS07045	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFH32_RS07055	COG1301	dicarboxylic acid transport
GFH32_RS07060	COG3339	Conserved Protein
GFH32_RS07195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH32_RS07200	COG0506	proline dehydrogenase activity
GFH32_RS07210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFH32_RS07225	COG2270	Major facilitator Superfamily
GFH32_RS07230	COG0247	lactate metabolic process
GFH32_RS07245	COG3104	oligopeptide transport
GFH32_RS07250	COG3104	oligopeptide transport
GFH32_RS07255	COG0463	Glycosyl transferase, family 2
GFH32_RS07260	COG2255	four-way junction helicase activity
GFH32_RS07275	COG1506	peptidase
GFH32_RS07275	COG0823	Involved in the tonB-independent uptake of proteins
GFH32_RS07295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFH32_RS07320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH32_RS07350	COG1129	ABC transporter
GFH32_RS07350	COG0842	Transport permease protein
GFH32_RS07355	COG0842	Transport permease protein
GFH32_RS07360	COG1131	(ABC) transporter
GFH32_RS07365	COG1131	(ABC) transporter
GFH32_RS07370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH32_RS07380	COG1309	transcriptional regulator
GFH32_RS07395	COG0673	inositol 2-dehydrogenase activity
GFH32_RS07400	COG4106	trans-aconitate 2-methyltransferase activity
GFH32_RS07405	COG0823	Involved in the tonB-independent uptake of proteins
GFH32_RS07405	COG1506	peptidase
GFH32_RS07440	COG4771	TonB-dependent receptor
GFH32_RS07525	COG2801	Transposase and inactivated derivatives
GFH32_RS07605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFH32_RS07610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFH32_RS07625	COG1629	transport
GFH32_RS07625	COG4206	TonB-dependent receptor
GFH32_RS07670	COG3118	belongs to the thioredoxin family
GFH32_RS07680	COG4206	TonB-dependent receptor
GFH32_RS07700	COG0667	Aldo Keto reductase
GFH32_RS07705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GFH32_RS07710	COG1428	Deoxynucleoside kinase
GFH32_RS07715	COG0180	Tryptophanyl-tRNA synthetase
GFH32_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS07735	COG2326	polyphosphate kinase activity
GFH32_RS07755	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GFH32_RS07760	COG3852	Histidine kinase
GFH32_RS07770	COG0481	GTPase activity
GFH32_RS07775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFH32_RS07800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GFH32_RS07805	COG0084	hydrolase, TatD family'
GFH32_RS07820	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFH32_RS07840	COG1104	cysteine desulfurase activity
GFH32_RS07845	COG0668	transmembrane transport
GFH32_RS07850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFH32_RS07855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH32_RS07860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFH32_RS07865	COG0673	inositol 2-dehydrogenase activity
GFH32_RS07875	COG1196	nuclear chromosome segregation
GFH32_RS07895	COG0326	Molecular chaperone. Has ATPase activity
GFH32_RS07905	COG0419	ATPase involved in DNA repair
GFH32_RS07910	COG0420	3'-5' exonuclease activity
GFH32_RS07945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFH32_RS07945	COG0519	Catalyzes the synthesis of GMP from XMP
GFH32_RS07955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFH32_RS07955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFH32_RS07960	COG0589	response to stress
GFH32_RS07970	COG0012	GTP binding
GFH32_RS07985	COG1132	(ABC) transporter
GFH32_RS08000	COG0488	(ABC) transporter
GFH32_RS08005	COG0167	dihydroorotate dehydrogenase activity
GFH32_RS08010	COG3015	lipoprotein NlpE involved in copper resistance
GFH32_RS08015	COG0517	IMP dehydrogenase activity
GFH32_RS08020	COG0351	phosphomethylpyrimidine kinase
GFH32_RS08045	COG0723	plastoquinol--plastocyanin reductase activity
GFH32_RS08045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH32_RS08085	COG4895	conserved protein (DUF2196)
GFH32_RS08090	COG1525	nuclease
GFH32_RS08130	COG0488	(ABC) transporter
GFH32_RS08140	COG2079	MmgE PrpD family protein
GFH32_RS08150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GFH32_RS08170	COG0564	pseudouridine synthase activity
GFH32_RS08175	COG0667	Aldo Keto reductase
GFH32_RS08180	COG0783	Belongs to the Dps family
GFH32_RS08200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFH32_RS08205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFH32_RS08210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFH32_RS08215	COG0527	aspartate kinase activity
GFH32_RS08220	COG0019	diaminopimelate decarboxylase activity
GFH32_RS08225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFH32_RS08235	COG2801	Transposase and inactivated derivatives
GFH32_RS08245	COG1278	Cold shock
GFH32_RS08265	COG4771	TonB-dependent receptor
GFH32_RS08270	COG0702	epimerase
GFH32_RS08295	COG4771	TonB-dependent receptor
GFH32_RS08310	COG3458	cephalosporin-C deacetylase activity
GFH32_RS08320	COG3275	phosphorelay sensor kinase activity
GFH32_RS08325	COG3279	Response regulator of the LytR AlgR family
GFH32_RS08395	COG1629	transport
GFH32_RS08415	COG1629	transport
GFH32_RS08420	COG0702	epimerase
GFH32_RS08425	COG2378	regulation of single-species biofilm formation
GFH32_RS08430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH32_RS08460	COG5002	protein histidine kinase activity
GFH32_RS08465	COG0745	RESPONSE REGULATOR receiver
GFH32_RS08470	COG2204	response regulator
GFH32_RS08485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GFH32_RS08495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GFH32_RS08505	COG2205	protein histidine kinase activity
GFH32_RS08520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH32_RS08545	COG0564	pseudouridine synthase activity
GFH32_RS08565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFH32_RS08575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH32_RS08580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH32_RS08590	COG1442	glycosyl transferase family 8
GFH32_RS08605	COG3475	LICD family
GFH32_RS08615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GFH32_RS08620	COG1216	Glycosyl transferase, family 2
GFH32_RS08635	COG0438	transferase activity, transferring glycosyl groups
GFH32_RS08640	COG0438	transferase activity, transferring glycosyl groups
GFH32_RS08655	COG1132	(ABC) transporter
GFH32_RS08670	COG3206	protein involved in exopolysaccharide biosynthesis
GFH32_RS08670	COG0489	protein tyrosine kinase activity
GFH32_RS08700	COG2223	nitrite transmembrane transporter activity
GFH32_RS08725	COG3250	beta-galactosidase activity
GFH32_RS08730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH32_RS08745	COG0702	epimerase
GFH32_RS08750	COG4771	TonB-dependent receptor
GFH32_RS08755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFH32_RS08770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS08775	COG0604	alcohol dehydrogenase
GFH32_RS08790	COG1629	transport
GFH32_RS08870	COG1595	DNA-templated transcription, initiation
GFH32_RS08880	COG4771	TonB-dependent receptor
GFH32_RS08885	COG0702	epimerase
GFH32_RS08890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS08895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH32_RS08900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS08905	COG0129	dihydroxy-acid dehydratase activity
GFH32_RS08920	COG3292	Two component regulator propeller
GFH32_RS08920	COG0745	RESPONSE REGULATOR receiver
GFH32_RS08920	COG2205	protein histidine kinase activity
GFH32_RS08925	COG0738	Major facilitator superfamily
GFH32_RS08935	COG1629	transport
GFH32_RS08935	COG4206	TonB-dependent receptor
GFH32_RS08940	COG0702	epimerase
GFH32_RS08965	COG1629	transport
GFH32_RS09050	COG2801	Transposase and inactivated derivatives
GFH32_RS09055	COG2801	Transposase and inactivated derivatives
GFH32_RS09145	COG2801	Transposase and inactivated derivatives
GFH32_RS09180	COG4221	oxidoreductase activity
GFH32_RS09220	COG2801	Transposase and inactivated derivatives
GFH32_RS09280	COG2801	Transposase and inactivated derivatives
GFH32_RS09340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFH32_RS09365	COG0196	riboflavin kinase activity
GFH32_RS09370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFH32_RS09375	COG1968	undecaprenyl-diphosphatase activity
GFH32_RS09385	COG2177	Part of the ABC transporter FtsEX involved in
GFH32_RS09390	COG0495	leucyl-tRNA aminoacylation
GFH32_RS09415	COG4974	Belongs to the 'phage' integrase family
GFH32_RS09420	COG0612	Peptidase, M16
GFH32_RS09430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFH32_RS09435	COG0254	rRNA binding
GFH32_RS09445	COG0149	triose-phosphate isomerase activity
GFH32_RS09450	COG2264	protein methyltransferase activity
GFH32_RS09455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFH32_RS09465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFH32_RS09470	COG3655	Transcriptional regulator
GFH32_RS09475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFH32_RS09485	COG0589	response to stress
GFH32_RS09485	COG0475	glutathione-regulated potassium exporter activity
GFH32_RS09490	COG0538	isocitrate dehydrogenase activity
GFH32_RS09500	COG1595	DNA-templated transcription, initiation
GFH32_RS09510	COG1629	transport
GFH32_RS09510	COG4206	TonB-dependent receptor
GFH32_RS09515	COG0702	epimerase
GFH32_RS09530	COG1966	Carbon starvation protein
GFH32_RS09540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GFH32_RS09585	COG4771	TonB-dependent receptor
GFH32_RS09610	COG1609	Transcriptional regulator
GFH32_RS09615	COG4771	TonB-dependent receptor
GFH32_RS09635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH32_RS09705	COG0702	epimerase
GFH32_RS09710	COG4771	TonB-dependent receptor
GFH32_RS09730	COG1629	transport
GFH32_RS09735	COG0702	epimerase
GFH32_RS09750	COG0583	DNA-binding transcription factor activity
GFH32_RS09760	COG3956	TIGRFAM MazG family protein
GFH32_RS09770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH32_RS09780	COG2885	chlorophyll binding
GFH32_RS09800	COG2885	chlorophyll binding
GFH32_RS09805	COG4771	TonB-dependent receptor
GFH32_RS09815	COG2895	sulfate adenylyltransferase (ATP) activity
GFH32_RS09820	COG0175	sulfate reduction
GFH32_RS09825	COG0175	sulfate reduction
GFH32_RS09830	COG1648	precorrin-2 dehydrogenase activity
GFH32_RS09830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFH32_RS09840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFH32_RS09845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFH32_RS09850	COG0573	inorganic phosphate transmembrane transporter activity
GFH32_RS09855	COG0581	inorganic phosphate transmembrane transporter activity
GFH32_RS09860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH32_RS09865	COG1301	dicarboxylic acid transport
GFH32_RS09875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFH32_RS09890	COG2884	Cell division ATP-binding protein ftsE
GFH32_RS09895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFH32_RS09900	COG0484	heat shock protein binding
GFH32_RS09905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GFH32_RS09910	COG0514	ATP-dependent DNA helicase (RecQ)
GFH32_RS09915	COG0517	IMP dehydrogenase activity
GFH32_RS09915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GFH32_RS09925	COG0436	Aminotransferase
GFH32_RS09945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFH32_RS09960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFH32_RS09965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GFH32_RS09970	COG4152	abc transporter atp-binding protein
GFH32_RS09975	COG1668	transmembrane transport
GFH32_RS09980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFH32_RS10005	COG0346	lactoylglutathione lyase activity
GFH32_RS10035	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GFH32_RS10040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFH32_RS10050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFH32_RS10065	COG1611	Belongs to the LOG family
GFH32_RS10070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFH32_RS10105	COG1201	RNA secondary structure unwinding
GFH32_RS10110	COG0431	NADPH-dependent FMN reductase
GFH32_RS10125	COG1253	flavin adenine dinucleotide binding
GFH32_RS10135	COG1253	flavin adenine dinucleotide binding
GFH32_RS10140	COG3118	belongs to the thioredoxin family
GFH32_RS10145	COG3757	hydrolase, family 25
GFH32_RS10150	COG3781	membrane
GFH32_RS10175	COG1215	transferase activity, transferring glycosyl groups
GFH32_RS10195	COG1917	Cupin 2, conserved barrel domain protein
GFH32_RS10195	COG2207	Transcriptional regulator
GFH32_RS10215	COG1566	PFAM secretion protein HlyD family protein
GFH32_RS10230	COG3279	Response regulator of the LytR AlgR family
GFH32_RS10235	COG0475	glutathione-regulated potassium exporter activity
GFH32_RS10245	COG2217	Heavy metal translocating P-type atpase
GFH32_RS10280	COG4771	TonB-dependent receptor
GFH32_RS10315	COG4152	abc transporter atp-binding protein
GFH32_RS10320	COG4133	protoheme IX ABC transporter activity
GFH32_RS10355	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GFH32_RS10395	COG3621	Patatin-like phospholipase
GFH32_RS10405	COG1803	Methylglyoxal synthase
GFH32_RS10415	COG1072	(Pantothenic acid kinase))
GFH32_RS10425	COG0825	malonyl-CoA metabolic process
GFH32_RS10430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH32_RS10480	COG0360	Binds together with S18 to 16S ribosomal RNA
GFH32_RS10485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFH32_RS10490	COG0359	binds to the 23S rRNA
GFH32_RS10500	COG0386	Belongs to the glutathione peroxidase family
GFH32_RS10510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH32_RS10520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFH32_RS10530	COG2502	aspartate--ammonia ligase
GFH32_RS10535	COG1199	ATP-dependent helicase activity
GFH32_RS10535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFH32_RS10540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFH32_RS10560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH32_RS10575	COG0693	protein deglycase activity
GFH32_RS10585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFH32_RS10615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFH32_RS10660	COG1609	Transcriptional regulator
GFH32_RS10665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GFH32_RS10675	COG0363	glucosamine-6-phosphate deaminase activity
GFH32_RS10680	COG0673	inositol 2-dehydrogenase activity
GFH32_RS10685	COG0673	inositol 2-dehydrogenase activity
GFH32_RS10700	COG4771	TonB-dependent receptor
GFH32_RS10710	COG3458	cephalosporin-C deacetylase activity
GFH32_RS10715	COG3132	Protein of unknown function, DUF480
GFH32_RS10740	COG4771	TonB-dependent receptor
GFH32_RS10770	COG0612	Peptidase, M16
GFH32_RS10775	COG0408	coproporphyrinogen oxidase activity
GFH32_RS10780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFH32_RS10795	COG0798	PFAM Bile acid sodium symporter
GFH32_RS10815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS10845	COG1733	regulation of RNA biosynthetic process
GFH32_RS10870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFH32_RS10875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFH32_RS10880	COG1480	7TM receptor with intracellular HD hydrolase
GFH32_RS10895	COG0300	oxidoreductase activity
GFH32_RS10905	COG0024	Methionine aminopeptidase
GFH32_RS10930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFH32_RS10940	COG0542	response to heat
GFH32_RS10945	COG1024	Enoyl-CoA hydratase
GFH32_RS10945	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH32_RS10950	COG1960	acyl-CoA dehydrogenase activity
GFH32_RS10965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH32_RS11060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFH32_RS11070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFH32_RS11075	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFH32_RS11080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GFH32_RS11085	COG0156	8-amino-7-oxononanoate synthase activity
GFH32_RS11095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH32_RS11185	COG3537	Alpha-1,2-mannosidase
GFH32_RS11190	COG0697	spore germination
GFH32_RS11210	COG0004	ammonium transporteR
GFH32_RS11220	COG3384	dioxygenase
GFH32_RS11240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFH32_RS11240	COG5180	pathogenesis
GFH32_RS11245	COG0195	Participates in both transcription termination and antitermination
GFH32_RS11250	COG0779	Required for maturation of 30S ribosomal subunits
GFH32_RS11295	COG0436	Aminotransferase
GFH32_RS11300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GFH32_RS11330	COG1629	transport
GFH32_RS11380	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GFH32_RS11400	COG3186	Phenylalanine-4-hydroxylase
GFH32_RS11405	COG1022	Amp-dependent synthetase and ligase
GFH32_RS11415	COG0402	S-adenosylhomocysteine deaminase activity
GFH32_RS11430	COG3189	MarR family transcriptional regulator
GFH32_RS11455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH32_RS11460	COG0038	chloride channel
GFH32_RS11465	COG3591	Belongs to the peptidase S1B family
GFH32_RS11465	COG4990	cell redox homeostasis
GFH32_RS11475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GFH32_RS11480	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GFH32_RS11490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFH32_RS11495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFH32_RS11515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFH32_RS11565	COG1595	DNA-templated transcription, initiation
GFH32_RS11570	COG1278	Cold shock
GFH32_RS11580	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GFH32_RS11585	COG3387	PFAM Glycoside hydrolase 15-related
GFH32_RS11595	COG5002	protein histidine kinase activity
GFH32_RS11600	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS11605	COG1058	Belongs to the CinA family
GFH32_RS11605	COG1546	Belongs to the CinA family
GFH32_RS11610	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GFH32_RS11620	COG2801	Transposase and inactivated derivatives
GFH32_RS11635	COG2801	Transposase and inactivated derivatives
GFH32_RS11650	COG2197	response regulator
GFH32_RS11655	COG1595	DNA-templated transcription, initiation
GFH32_RS11675	COG3685	Protein conserved in bacteria
GFH32_RS11750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFH32_RS11780	COG2197	response regulator
GFH32_RS11800	COG0673	inositol 2-dehydrogenase activity
GFH32_RS11815	COG4771	TonB-dependent receptor
GFH32_RS11835	COG3279	Response regulator of the LytR AlgR family
GFH32_RS11840	COG3275	phosphorelay sensor kinase activity
GFH32_RS11925	COG1629	transport
GFH32_RS11950	COG1793	dna ligase
GFH32_RS11975	COG0745	RESPONSE REGULATOR receiver
GFH32_RS11980	COG3437	response regulator, receiver
GFH32_RS11980	COG2205	protein histidine kinase activity
GFH32_RS11980	COG3850	Histidine kinase
GFH32_RS11980	COG4999	Histidine kinase
GFH32_RS12020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GFH32_RS12030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFH32_RS12030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFH32_RS12050	COG1131	(ABC) transporter
GFH32_RS12105	COG2885	chlorophyll binding
GFH32_RS12120	COG2207	Transcriptional regulator
GFH32_RS12120	COG1917	Cupin 2, conserved barrel domain protein
GFH32_RS12125	COG1609	Transcriptional regulator
GFH32_RS12135	COG1904	glucuronate isomerase
GFH32_RS12140	COG2721	sulfolactate sulfo-lyase activity
GFH32_RS12145	COG0246	Mannitol dehydrogenase
GFH32_RS12150	COG2205	protein histidine kinase activity
GFH32_RS12160	COG3386	PFAM SMP-30 Gluconolaconase
GFH32_RS12175	COG2186	Transcriptional regulator
GFH32_RS12200	COG2819	hydrolase of the alpha beta superfamily
GFH32_RS12205	COG2207	Transcriptional regulator
GFH32_RS12210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GFH32_RS12215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH32_RS12220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFH32_RS12250	COG1929	Belongs to the glycerate kinase type-1 family
GFH32_RS12260	COG2271	Major facilitator Superfamily
GFH32_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS12315	COG2186	Transcriptional regulator
GFH32_RS12320	COG0702	epimerase
GFH32_RS12325	COG1629	transport
GFH32_RS12330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH32_RS12335	COG3781	membrane
GFH32_RS12385	COG0561	phosphatase activity
GFH32_RS12390	COG1629	transport
GFH32_RS12405	COG1940	carbohydrate kinase activity
GFH32_RS12410	COG4771	TonB-dependent receptor
GFH32_RS12420	COG0745	RESPONSE REGULATOR receiver
GFH32_RS12420	COG2205	protein histidine kinase activity
GFH32_RS12420	COG3292	Two component regulator propeller
GFH32_RS12435	COG1629	transport
GFH32_RS12440	COG3250	beta-galactosidase activity
GFH32_RS12445	COG2354	Protein conserved in bacteria
GFH32_RS12465	COG0702	epimerase
GFH32_RS12470	COG4771	TonB-dependent receptor
GFH32_RS12480	COG0363	glucosamine-6-phosphate deaminase activity
GFH32_RS12485	COG1609	Transcriptional regulator
GFH32_RS12490	COG0673	inositol 2-dehydrogenase activity
GFH32_RS12510	COG1473	amidohydrolase
GFH32_RS12550	COG4771	TonB-dependent receptor
GFH32_RS12555	COG0673	inositol 2-dehydrogenase activity
GFH32_RS12560	COG1595	DNA-templated transcription, initiation
GFH32_RS12570	COG1629	transport
GFH32_RS12615	COG3237	CsbD-like
GFH32_RS12625	COG0577	efflux transmembrane transporter activity
GFH32_RS12630	COG4181	ATPase activity
GFH32_RS12645	COG0659	secondary active sulfate transmembrane transporter activity
GFH32_RS12650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH32_RS12655	COG0581	inorganic phosphate transmembrane transporter activity
GFH32_RS12660	COG0573	inorganic phosphate transmembrane transporter activity
GFH32_RS12670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS12680	COG1629	transport
GFH32_RS12685	COG0702	epimerase
GFH32_RS12705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFH32_RS12705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH32_RS12760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFH32_RS12770	COG0557	exoribonuclease II activity
GFH32_RS12775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFH32_RS12780	COG0049	tRNA binding
GFH32_RS12785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFH32_RS12790	COG0051	transcription antitermination factor activity, RNA binding
GFH32_RS12795	COG0300	oxidoreductase activity
GFH32_RS12815	COG3142	Participates in the control of copper homeostasis
GFH32_RS12830	COG0584	glycerophosphoryl diester phosphodiesterase
GFH32_RS12835	COG0823	Involved in the tonB-independent uptake of proteins
GFH32_RS12840	COG4232	protein-disulfide reductase activity
GFH32_RS12845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFH32_RS12850	COG1522	sequence-specific DNA binding
GFH32_RS12855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS12890	COG1629	transport
GFH32_RS12890	COG4206	TonB-dependent receptor
GFH32_RS12895	COG2226	methyltransferase
GFH32_RS12940	COG0673	inositol 2-dehydrogenase activity
GFH32_RS12950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFH32_RS12955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFH32_RS12960	COG0745	RESPONSE REGULATOR receiver
GFH32_RS12965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS12970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFH32_RS12985	COG2885	chlorophyll binding
GFH32_RS12995	COG0531	amino acid
GFH32_RS13000	COG0513	Belongs to the DEAD box helicase family
GFH32_RS13010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH32_RS13015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFH32_RS13020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFH32_RS13030	COG0791	NLP P60 protein
GFH32_RS13045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH32_RS13050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFH32_RS13055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFH32_RS13075	COG1022	Amp-dependent synthetase and ligase
GFH32_RS13080	COG1295	ribonuclease BN
GFH32_RS13085	COG0697	spore germination
GFH32_RS13095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFH32_RS13110	COG0348	domain, Protein
GFH32_RS13135	COG1187	pseudouridine synthase activity
GFH32_RS13145	COG1242	4 iron, 4 sulfur cluster binding
GFH32_RS13190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH32_RS13205	COG2217	Heavy metal translocating P-type atpase
GFH32_RS13210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH32_RS13225	COG4191	Histidine kinase
GFH32_RS13230	COG0488	(ABC) transporter
GFH32_RS13235	COG0542	response to heat
GFH32_RS13250	COG0497	DNA recombination
GFH32_RS13275	COG0626	cystathionine gamma-synthase activity
GFH32_RS13285	COG0442	prolyl-tRNA aminoacylation
GFH32_RS13310	COG1030	water channel activity
GFH32_RS13320	COG3942	CHAP domain
GFH32_RS13320	COG1388	LysM domain
GFH32_RS13325	COG0572	uridine kinase
GFH32_RS13330	COG2814	Major facilitator Superfamily
GFH32_RS13345	COG1999	signal sequence binding
GFH32_RS13365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH32_RS13400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFH32_RS13405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFH32_RS13430	COG0148	phosphopyruvate hydratase activity
GFH32_RS13435	COG0505	Belongs to the CarA family
GFH32_RS13440	COG0750	zinc metalloprotease
GFH32_RS13445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GFH32_RS13470	COG3275	phosphorelay sensor kinase activity
GFH32_RS13475	COG3279	Response regulator of the LytR AlgR family
GFH32_RS13490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFH32_RS13495	COG2382	esterase
GFH32_RS13500	COG0138	bifunctional purine biosynthesis protein purh
GFH32_RS13520	COG4067	protein conserved in archaea
GFH32_RS13520	COG0189	ligase activity
GFH32_RS13525	COG0189	ligase activity
GFH32_RS13540	COG0406	alpha-ribazole phosphatase activity
GFH32_RS13545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH32_RS13550	COG1070	Carbohydrate kinase
GFH32_RS13555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH32_RS13560	COG2814	Major facilitator Superfamily
GFH32_RS13570	COG0445	tRNA wobble uridine modification
GFH32_RS13575	COG2271	Major facilitator Superfamily
GFH32_RS13580	COG1349	DNA-binding transcription factor activity
GFH32_RS13585	COG4771	TonB-dependent receptor
GFH32_RS13590	COG0702	epimerase
GFH32_RS13600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFH32_RS13605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFH32_RS13610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFH32_RS13615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFH32_RS13625	COG0602	queuosine metabolic process
GFH32_RS13630	COG2885	chlorophyll binding
GFH32_RS13635	COG0673	inositol 2-dehydrogenase activity
GFH32_RS13640	COG0673	inositol 2-dehydrogenase activity
GFH32_RS13665	COG4206	TonB-dependent receptor
GFH32_RS13675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFH32_RS13685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GFH32_RS13690	COG1104	cysteine desulfurase activity
GFH32_RS13705	COG2086	electron transfer activity
GFH32_RS13710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFH32_RS13720	COG2211	Major facilitator Superfamily
GFH32_RS13735	COG1136	(ABC) transporter
GFH32_RS13740	COG0577	efflux transmembrane transporter activity
GFH32_RS13750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFH32_RS13755	COG1253	flavin adenine dinucleotide binding
GFH32_RS13770	COG0586	Pfam SNARE associated Golgi protein
GFH32_RS13775	COG0537	adenosine 5'-monophosphoramidase activity
GFH32_RS13780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFH32_RS13785	COG0745	RESPONSE REGULATOR receiver
GFH32_RS13790	COG5002	protein histidine kinase activity
GFH32_RS13815	COG0564	pseudouridine synthase activity
GFH32_RS13825	COG1127	ABC transporter
GFH32_RS13830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFH32_RS13840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFH32_RS13845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFH32_RS13850	COG2373	Large extracellular alpha-helical protein
GFH32_RS13855	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GFH32_RS13860	COG0514	ATP-dependent DNA helicase (RecQ)
GFH32_RS13865	COG2333	competence protein COMEC
GFH32_RS13865	COG0658	competence protein
GFH32_RS13885	COG0187	DNA topoisomerase II activity
GFH32_RS13895	COG0598	Magnesium transport protein CorA
GFH32_RS13900	COG1214	PFAM Peptidase M22, glycoprotease
GFH32_RS13905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFH32_RS13910	COG0594	ribonuclease P activity
GFH32_RS13915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GFH32_RS13920	COG1970	mechanosensitive ion channel activity
GFH32_RS13925	COG2197	response regulator
GFH32_RS13940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFH32_RS13955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFH32_RS13960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFH32_RS13965	COG0772	Belongs to the SEDS family
GFH32_RS13970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFH32_RS13975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH32_RS13980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFH32_RS13995	COG0275	rRNA processing
GFH32_RS14000	COG2001	Belongs to the MraZ family
GFH32_RS14005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFH32_RS14010	COG1139	Iron-sulfur cluster binding protein
GFH32_RS14015	COG2304	oxidoreductase activity
GFH32_RS14030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFH32_RS14055	COG1595	DNA-templated transcription, initiation
GFH32_RS14070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH32_RS14085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFH32_RS14090	COG0083	homoserine kinase activity
GFH32_RS14095	COG0527	aspartate kinase activity
GFH32_RS14095	COG0460	homoserine dehydrogenase
GFH32_RS14100	COG0791	NLP P60 protein
GFH32_RS14115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFH32_RS14135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFH32_RS14140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFH32_RS14145	COG0052	Belongs to the universal ribosomal protein uS2 family
GFH32_RS14150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFH32_RS14160	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS14165	COG4771	TonB-dependent receptor
GFH32_RS14175	COG1233	COG1233 Phytoene dehydrogenase and related
GFH32_RS14180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFH32_RS14195	COG0488	(ABC) transporter
GFH32_RS14230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH32_RS14230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH32_RS14235	COG1012	belongs to the aldehyde dehydrogenase family
GFH32_RS14245	COG1981	membrane
GFH32_RS14250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFH32_RS14260	COG0745	RESPONSE REGULATOR receiver
GFH32_RS14265	COG5002	protein histidine kinase activity
GFH32_RS14270	COG1011	Hydrolase
GFH32_RS14295	COG2721	sulfolactate sulfo-lyase activity
GFH32_RS14300	COG2721	sulfolactate sulfo-lyase activity
GFH32_RS14320	COG4771	TonB-dependent receptor
GFH32_RS14345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GFH32_RS14350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH32_RS14360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFH32_RS14365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFH32_RS14370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH32_RS14375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFH32_RS14380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH32_RS14385	COG0356	it plays a direct role in the translocation of protons across the membrane
GFH32_RS14400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH32_RS14415	COG0788	formyltetrahydrofolate deformylase activity
GFH32_RS14425	COG0116	Belongs to the methyltransferase superfamily
GFH32_RS14425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GFH32_RS14430	COG1127	ABC transporter
GFH32_RS14435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFH32_RS14445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFH32_RS14455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFH32_RS14465	COG0839	Belongs to the complex I subunit 6 family
GFH32_RS14470	COG0713	ATP synthesis coupled electron transport
GFH32_RS14475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH32_RS14485	COG1007	ATP synthesis coupled electron transport
GFH32_RS14505	COG0438	transferase activity, transferring glycosyl groups
GFH32_RS14515	COG1215	transferase activity, transferring glycosyl groups
GFH32_RS14530	COG1215	transferase activity, transferring glycosyl groups
GFH32_RS14545	COG1331	Highly conserved protein containing a thioredoxin domain
GFH32_RS14550	COG1047	Peptidyl-prolyl cis-trans
GFH32_RS14560	COG1301	dicarboxylic acid transport
GFH32_RS14575	COG1138	Cytochrome C-type biogenesis protein
GFH32_RS14585	COG0069	glutamate synthase activity
GFH32_RS14600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH32_RS14620	COG0322	excinuclease ABC activity
GFH32_RS14635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFH32_RS14640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFH32_RS14645	COG0297	glycogen (starch) synthase activity
GFH32_RS14650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFH32_RS14655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFH32_RS14665	COG4771	TonB-dependent receptor
GFH32_RS14675	COG0545	Peptidyl-prolyl cis-trans isomerase
GFH32_RS14690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH32_RS14690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFH32_RS14705	COG2837	iron assimilation
GFH32_RS14720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFH32_RS14745	COG0673	inositol 2-dehydrogenase activity
GFH32_RS14770	COG2234	aminopeptidase activity
GFH32_RS14815	COG1629	transport
GFH32_RS14825	COG4952	isomerase
GFH32_RS14830	COG3347	Dehydrogenase
GFH32_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS14840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFH32_RS14845	COG0183	Belongs to the thiolase family
GFH32_RS14850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GFH32_RS14860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFH32_RS14865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFH32_RS14875	COG0129	dihydroxy-acid dehydratase activity
GFH32_RS14880	COG0028	Belongs to the TPP enzyme family
GFH32_RS14885	COG0440	acetolactate synthase activity
GFH32_RS14895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFH32_RS14900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFH32_RS14905	COG2329	Antibiotic biosynthesis monooxygenase
GFH32_RS14910	COG0066	3-isopropylmalate dehydratase activity
GFH32_RS14915	COG1119	ATPase activity
GFH32_RS14925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH32_RS14930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFH32_RS14950	COG1780	Probably involved in ribonucleotide reductase function
GFH32_RS14955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFH32_RS14960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFH32_RS14980	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH32_RS14990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFH32_RS14995	COG0423	glycine-tRNA ligase activity
GFH32_RS15030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GFH32_RS15045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFH32_RS15050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFH32_RS15055	COG1012	belongs to the aldehyde dehydrogenase family
GFH32_RS15070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH32_RS15090	COG1053	succinate dehydrogenase
GFH32_RS15110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GFH32_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS15135	COG4771	TonB-dependent receptor
GFH32_RS15140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH32_RS15170	COG1215	transferase activity, transferring glycosyl groups
GFH32_RS15180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GFH32_RS15190	COG1522	sequence-specific DNA binding
GFH32_RS15195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH32_RS15200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFH32_RS15205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFH32_RS15210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFH32_RS15220	COG0203	ribosomal protein L17
GFH32_RS15225	COG0202	RNA polymerase activity
GFH32_RS15230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFH32_RS15235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFH32_RS15240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFH32_RS15245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFH32_RS15250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFH32_RS15260	COG0201	protein transport
GFH32_RS15265	COG0200	Binds to the 23S rRNA
GFH32_RS15270	COG1841	ribosomal large subunit assembly
GFH32_RS15275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFH32_RS15285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFH32_RS15290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFH32_RS15295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFH32_RS15300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFH32_RS15305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFH32_RS15310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFH32_RS15315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFH32_RS15320	COG0255	Belongs to the universal ribosomal protein uL29 family
GFH32_RS15325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFH32_RS15330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFH32_RS15335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFH32_RS15340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFH32_RS15345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFH32_RS15350	COG0089	rRNA binding
GFH32_RS15355	COG0088	Forms part of the polypeptide exit tunnel
GFH32_RS15360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFH32_RS15365	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH32_RS15375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFH32_RS15390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFH32_RS15395	COG0124	histidyl-tRNA synthetase
GFH32_RS15400	COG0571	ribonuclease III activity
GFH32_RS15405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH32_RS15410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH32_RS15420	COG0469	pyruvate kinase activity
GFH32_RS15445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFH32_RS15450	COG0531	amino acid
GFH32_RS15465	COG1304	FMN binding
GFH32_RS15470	COG0556	nucleotide-excision repair
GFH32_RS15475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFH32_RS15495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFH32_RS15515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFH32_RS15525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFH32_RS15530	COG0673	inositol 2-dehydrogenase activity
GFH32_RS15540	COG1609	Transcriptional regulator
GFH32_RS15565	COG1136	(ABC) transporter
GFH32_RS15570	COG0045	succinate-CoA ligase (ADP-forming) activity
GFH32_RS15575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFH32_RS15590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFH32_RS15595	COG0456	acetyltransferase
GFH32_RS15600	COG0137	argininosuccinate synthase activity
GFH32_RS15640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFH32_RS15645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH32_RS15685	COG1960	acyl-CoA dehydrogenase activity
GFH32_RS15690	COG1012	belongs to the aldehyde dehydrogenase family
GFH32_RS15700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFH32_RS15745	COG3853	Toxic anion resistance protein (TelA)
GFH32_RS15760	COG4682	membrane
GFH32_RS15780	COG3047	cAMP biosynthetic process
GFH32_RS15790	COG0116	Belongs to the methyltransferase superfamily
GFH32_RS15790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GFH32_RS15795	COG1418	mRNA catabolic process
GFH32_RS15805	COG0584	glycerophosphoryl diester phosphodiesterase
GFH32_RS15820	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFH32_RS15845	COG2855	membrane
GFH32_RS15850	COG1090	epimerase
GFH32_RS15860	COG1960	acyl-CoA dehydrogenase activity
GFH32_RS15865	COG0183	Belongs to the thiolase family
GFH32_RS15875	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH32_RS15875	COG1024	Enoyl-CoA hydratase
GFH32_RS15890	COG2315	Protein conserved in bacteria
GFH32_RS15900	COG0443	Heat shock 70 kDa protein
GFH32_RS15915	COG0433	COG0433 Predicted ATPase
GFH32_RS15925	COG0659	secondary active sulfate transmembrane transporter activity
GFH32_RS15930	COG0288	reversible hydration of carbon dioxide
GFH32_RS15940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFH32_RS15950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GFH32_RS15955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFH32_RS15960	COG1629	transport
GFH32_RS15970	COG0228	four-way junction DNA binding
GFH32_RS15975	COG1074	ATP-dependent DNA helicase activity
GFH32_RS16005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFH32_RS16020	COG0519	Catalyzes the synthesis of GMP from XMP
GFH32_RS16025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GFH32_RS16030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH32_RS16035	COG0489	protein tyrosine kinase activity
GFH32_RS16045	COG1629	transport
GFH32_RS16045	COG4206	TonB-dependent receptor
GFH32_RS16060	COG1629	transport
GFH32_RS16060	COG4206	TonB-dependent receptor
GFH32_RS16065	COG0336	Belongs to the RNA methyltransferase TrmD family
GFH32_RS16070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFH32_RS16075	COG0512	Glutamine amidotransferase of anthranilate synthase
GFH32_RS16080	COG0134	indole-3-glycerol-phosphate synthase activity
GFH32_RS16085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFH32_RS16090	COG2244	polysaccharide biosynthetic process
GFH32_RS16095	COG1254	Belongs to the acylphosphatase family
GFH32_RS16100	COG0402	S-adenosylhomocysteine deaminase activity
GFH32_RS16115	COG1694	Mazg nucleotide pyrophosphohydrolase
GFH32_RS16125	COG0405	Gamma-glutamyltransferase
GFH32_RS16135	COG0010	Belongs to the arginase family
GFH32_RS16140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH32_RS16145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH32_RS16150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFH32_RS16155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFH32_RS16160	COG4133	protoheme IX ABC transporter activity
GFH32_RS16165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH32_RS16170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GFH32_RS16170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFH32_RS16175	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH32_RS16180	COG1078	dGTPase activity
GFH32_RS16185	COG5002	protein histidine kinase activity
GFH32_RS16185	COG0784	Response regulator, receiver
GFH32_RS16185	COG2205	protein histidine kinase activity
GFH32_RS16190	COG0802	atpase or kinase
GFH32_RS16220	COG0686	Belongs to the AlaDH PNT family
GFH32_RS16235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFH32_RS16290	COG0702	epimerase
GFH32_RS16295	COG4771	TonB-dependent receptor
GFH32_RS16300	COG1028	Short-chain dehydrogenase reductase Sdr
GFH32_RS16305	COG4677	pectinesterase activity
GFH32_RS16310	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GFH32_RS16330	COG2197	response regulator
GFH32_RS16340	COG4771	TonB-dependent receptor
GFH32_RS16365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS16385	COG0667	Aldo Keto reductase
GFH32_RS16405	COG0459	protein refolding
GFH32_RS16410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFH32_RS16430	COG2204	response regulator
GFH32_RS16435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH32_RS16445	COG2885	chlorophyll binding
GFH32_RS16460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFH32_RS16470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFH32_RS16480	COG1194	a g-specific adenine glycosylase
GFH32_RS16485	COG0739	heme binding
GFH32_RS16505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GFH32_RS16530	COG1136	(ABC) transporter
GFH32_RS16580	COG1690	Belongs to the RtcB family
GFH32_RS16605	COG3177	Filamentation induced by cAMP protein fic
GFH32_RS16610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH32_RS16620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFH32_RS16620	COG1519	Transferase
GFH32_RS16625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH32_RS16630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFH32_RS16640	COG2207	Transcriptional regulator
GFH32_RS16660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFH32_RS16670	COG0626	cystathionine gamma-synthase activity
GFH32_RS16675	COG1595	DNA-templated transcription, initiation
GFH32_RS16685	COG4206	TonB-dependent receptor
GFH32_RS16685	COG1629	transport
GFH32_RS16705	COG4771	TonB-dependent receptor
GFH32_RS16710	COG0745	RESPONSE REGULATOR receiver
GFH32_RS16710	COG3292	Two component regulator propeller
GFH32_RS16710	COG2205	protein histidine kinase activity
GFH32_RS16730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFH32_RS16735	COG1085	galactose-1-phosphate uridylyltransferase
GFH32_RS16765	COG1408	metallophosphoesterase
GFH32_RS16770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GFH32_RS16775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GFH32_RS16785	COG0105	UTP biosynthetic process
GFH32_RS16805	COG3119	arylsulfatase activity
GFH32_RS16820	COG1629	transport
GFH32_RS16840	COG4948	Mandelate Racemase Muconate Lactonizing
GFH32_RS16845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFH32_RS16850	COG1802	Transcriptional regulator
GFH32_RS16860	COG0561	phosphatase activity
GFH32_RS16865	COG1629	transport
GFH32_RS16870	COG2885	chlorophyll binding
GFH32_RS16885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFH32_RS16890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFH32_RS16915	COG1629	transport
GFH32_RS16925	COG5652	VanZ like family
GFH32_RS16935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH32_RS16955	COG4771	TonB-dependent receptor
GFH32_RS17000	COG1629	transport
GFH32_RS17025	COG4771	TonB-dependent receptor
GFH32_RS17105	COG3279	Response regulator of the LytR AlgR family
GFH32_RS17145	COG1629	transport
GFH32_RS17145	COG4206	TonB-dependent receptor
GFH32_RS17180	COG1132	(ABC) transporter
GFH32_RS17205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH32_RS17205	COG2755	lipolytic protein G-D-S-L family
GFH32_RS17215	COG0358	DNA primase activity
GFH32_RS17225	COG0489	protein tyrosine kinase activity
GFH32_RS17240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH32_RS17270	COG0110	maltose O-acetyltransferase activity
GFH32_RS17280	COG1045	serine acetyltransferase
GFH32_RS17285	COG0297	glycogen (starch) synthase activity
GFH32_RS17285	COG0438	transferase activity, transferring glycosyl groups
GFH32_RS17295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GFH32_RS17300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH32_RS17310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFH32_RS17330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFH32_RS17360	COG2176	DNA-directed DNA polymerase activity
GFH32_RS17365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFH32_RS17375	COG0793	Belongs to the peptidase S41A family
GFH32_RS17385	COG4771	TonB-dependent receptor
GFH32_RS17415	COG0673	inositol 2-dehydrogenase activity
GFH32_RS17420	COG1473	amidohydrolase
GFH32_RS17430	COG4771	TonB-dependent receptor
GFH32_RS17465	COG1024	Enoyl-CoA hydratase
GFH32_RS17475	COG1007	ATP synthesis coupled electron transport
GFH32_RS17480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS17485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH32_RS17490	COG0713	ATP synthesis coupled electron transport
GFH32_RS17495	COG0839	Belongs to the complex I subunit 6 family
GFH32_RS17500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS17505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFH32_RS17510	COG1034	ATP synthesis coupled electron transport
GFH32_RS17520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GFH32_RS17525	COG0649	NAD binding
GFH32_RS17530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS17535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS17540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH32_RS17560	COG0848	biopolymer transport protein
GFH32_RS17585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFH32_RS17590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFH32_RS17595	COG0612	Peptidase, M16
GFH32_RS17600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH32_RS17605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH32_RS17630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFH32_RS17640	COG0569	domain protein
GFH32_RS17645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFH32_RS17655	COG1162	GTPase activity
GFH32_RS17660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH32_RS17660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH32_RS17670	COG0688	phosphatidylethanolamine metabolic process
GFH32_RS17675	COG5002	protein histidine kinase activity
GFH32_RS17685	COG0306	phosphate transporter
GFH32_RS17690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH32_RS17690	COG2885	chlorophyll binding
GFH32_RS17700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFH32_RS17710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH32_RS17715	COG4591	ABC-type transport system involved in lipoprotein release permease component
GFH32_RS17745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFH32_RS17745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GFH32_RS17790	COG2860	membrane
GFH32_RS17795	COG0242	peptide deformylase activity
GFH32_RS17805	COG0673	inositol 2-dehydrogenase activity
GFH32_RS17815	COG1530	ribonuclease E activity
GFH32_RS17825	COG0776	regulation of translation
GFH32_RS17845	COG2972	Histidine kinase
GFH32_RS17850	COG3279	Response regulator of the LytR AlgR family
GFH32_RS17875	COG0688	phosphatidylethanolamine metabolic process
GFH32_RS17970	COG1629	transport
GFH32_RS17990	COG0457	Tetratricopeptide repeat
GFH32_RS18000	COG0450	alkyl hydroperoxide reductase
GFH32_RS18030	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH32_RS18045	COG1388	LysM domain
GFH32_RS18045	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFH32_RS18060	COG0302	gtp cyclohydrolase
GFH32_RS18075	COG0022	dehydrogenase e1 component
GFH32_RS18075	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH32_RS18085	COG0509	glycine decarboxylation via glycine cleavage system
GFH32_RS18090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GFH32_RS18115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFH32_RS18120	COG0793	Belongs to the peptidase S41A family
GFH32_RS18120	COG4946	Tricorn protease homolog
GFH32_RS18130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFH32_RS18140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFH32_RS18150	COG0488	(ABC) transporter
GFH32_RS18155	COG0445	tRNA wobble uridine modification
GFH32_RS18165	COG4451	ribulose bisphosphate carboxylase, small
GFH32_RS18165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFH32_RS18170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFH32_RS18175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFH32_RS18180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GFH32_RS18185	COG2197	response regulator
GFH32_RS18190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH32_RS18195	COG1960	acyl-CoA dehydrogenase activity
GFH32_RS18210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GFH32_RS18215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)