locus-tag	class	description
SPBM01_RS00015	COG1823	symporter activity
SPBM01_RS00025	COG0180	Tryptophanyl-tRNA synthetase
SPBM01_RS00030	COG0728	peptidoglycan biosynthetic process
SPBM01_RS00035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SPBM01_RS00040	COG4395	Tim44
SPBM01_RS00055	COG3300	MHYT domain
SPBM01_RS00055	COG5001	Diguanylate cyclase
SPBM01_RS00060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPBM01_RS00070	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPBM01_RS00080	COG0175	sulfate reduction
SPBM01_RS00090	COG1218	3'(2'),5'-bisphosphate nucleotidase
SPBM01_RS00095	COG0659	secondary active sulfate transmembrane transporter activity
SPBM01_RS00105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SPBM01_RS00135	COG0318	PFAM AMP-dependent synthetase and ligase
SPBM01_RS00140	COG5001	Diguanylate cyclase
SPBM01_RS00150	COG1393	Belongs to the ArsC family
SPBM01_RS00155	COG0439	Biotin carboxylase
SPBM01_RS00170	COG2022	thiamine diphosphate biosynthetic process
SPBM01_RS00190	COG0537	adenosine 5'-monophosphoramidase activity
SPBM01_RS00235	COG0456	acetyltransferase
SPBM01_RS00240	COG1597	lipid kinase activity
SPBM01_RS00245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SPBM01_RS00250	COG2226	methyltransferase
SPBM01_RS00255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPBM01_RS00260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPBM01_RS00265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPBM01_RS00305	COG0598	Magnesium transport protein CorA
SPBM01_RS00325	COG0659	secondary active sulfate transmembrane transporter activity
SPBM01_RS00340	COG2205	protein histidine kinase activity
SPBM01_RS00345	COG1045	serine acetyltransferase
SPBM01_RS00365	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPBM01_RS00375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPBM01_RS00395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPBM01_RS00400	COG0252	asparaginase activity
SPBM01_RS00410	COG1329	Transcriptional regulator
SPBM01_RS00415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SPBM01_RS00430	COG0739	heme binding
SPBM01_RS00440	COG3300	MHYT domain
SPBM01_RS00440	COG5001	Diguanylate cyclase
SPBM01_RS00460	COG3237	CsbD-like
SPBM01_RS00465	COG1115	amino acid carrier protein
SPBM01_RS00470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPBM01_RS00475	COG3813	Protein conserved in bacteria
SPBM01_RS00480	COG0351	phosphomethylpyrimidine kinase
SPBM01_RS00480	COG0352	thiamine-phosphate diphosphorylase activity
SPBM01_RS00485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPBM01_RS00495	COG4774	siderophore transport
SPBM01_RS00520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SPBM01_RS00565	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS00570	COG0704	Plays a role in the regulation of phosphate uptake
SPBM01_RS00575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPBM01_RS00585	COG0573	inorganic phosphate transmembrane transporter activity
SPBM01_RS00605	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS00650	COG2321	neutral zinc metallopeptidase
SPBM01_RS00665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SPBM01_RS00670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPBM01_RS00680	COG4942	peptidase
SPBM01_RS00685	COG0316	Belongs to the HesB IscA family
SPBM01_RS00700	COG4149	molybdate abc transporter
SPBM01_RS00705	COG0725	ABC transporter, periplasmic molybdate-binding protein
SPBM01_RS00710	COG0243	molybdopterin cofactor binding
SPBM01_RS00715	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS00740	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SPBM01_RS00750	COG1970	mechanosensitive ion channel activity
SPBM01_RS00760	COG0643	Histidine kinase
SPBM01_RS00760	COG0784	Response regulator, receiver
SPBM01_RS00760	COG2198	Histidine kinase
SPBM01_RS00770	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS00775	COG2201	protein-glutamate methylesterase activity
SPBM01_RS00780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SPBM01_RS00785	COG3023	N-Acetylmuramoyl-L-alanine amidase
SPBM01_RS00795	COG0484	heat shock protein binding
SPBM01_RS00830	COG0552	protein localization to endoplasmic reticulum
SPBM01_RS00835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPBM01_RS00840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SPBM01_RS00855	COG0531	amino acid
SPBM01_RS00860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPBM01_RS00865	COG0228	four-way junction DNA binding
SPBM01_RS00870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPBM01_RS00895	COG0336	Belongs to the RNA methyltransferase TrmD family
SPBM01_RS00900	COG0335	large ribosomal subunit rRNA binding
SPBM01_RS00905	COG0477	Major facilitator Superfamily
SPBM01_RS00910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPBM01_RS00915	COG0628	permease
SPBM01_RS00920	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS00955	COG1758	RNA polymerase activity
SPBM01_RS00960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPBM01_RS00965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPBM01_RS00965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPBM01_RS00970	COG1660	Displays ATPase and GTPase activities
SPBM01_RS00980	COG0222	ribosome binding
SPBM01_RS00985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPBM01_RS00995	COG1733	regulation of RNA biosynthetic process
SPBM01_RS01000	COG3275	phosphorelay sensor kinase activity
SPBM01_RS01005	COG3279	Response regulator of the LytR AlgR family
SPBM01_RS01025	COG0590	tRNA wobble adenosine to inosine editing
SPBM01_RS01035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPBM01_RS01105	COG0477	Major facilitator Superfamily
SPBM01_RS01130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPBM01_RS01135	COG0066	3-isopropylmalate dehydratase activity
SPBM01_RS01150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SPBM01_RS01155	COG3682	Transcriptional regulator
SPBM01_RS01165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPBM01_RS01175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPBM01_RS01180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SPBM01_RS01190	COG1420	regulation of RNA biosynthetic process
SPBM01_RS01195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPBM01_RS01215	COG2866	Carboxypeptidase
SPBM01_RS01225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPBM01_RS01230	COG0469	pyruvate kinase activity
SPBM01_RS01245	COG0217	transcriptional regulatory protein
SPBM01_RS01250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SPBM01_RS01280	COG1053	succinate dehydrogenase
SPBM01_RS01290	COG3609	addiction module antidote protein, CC2985 family
SPBM01_RS01305	COG0443	Heat shock 70 kDa protein
SPBM01_RS01310	COG0484	heat shock protein binding
SPBM01_RS01315	COG0531	amino acid
SPBM01_RS01320	COG1408	metallophosphoesterase
SPBM01_RS01325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPBM01_RS01335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPBM01_RS01335	COG3153	acetyltransferase
SPBM01_RS01340	COG0538	isocitrate dehydrogenase activity
SPBM01_RS01345	COG0688	phosphatidylethanolamine metabolic process
SPBM01_RS01350	COG1183	phosphatidylcholine synthase activity
SPBM01_RS01360	COG0052	Belongs to the universal ribosomal protein uS2 family
SPBM01_RS01365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPBM01_RS01370	COG0528	UMP kinase activity
SPBM01_RS01375	COG0233	cytoplasmic translational termination
SPBM01_RS01380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPBM01_RS01390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPBM01_RS01395	COG0750	zinc metalloprotease
SPBM01_RS01400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPBM01_RS01410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPBM01_RS01415	COG0254	rRNA binding
SPBM01_RS01420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPBM01_RS01425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPBM01_RS01440	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS01445	COG0825	malonyl-CoA metabolic process
SPBM01_RS01465	COG0494	nUDIX hydrolase
SPBM01_RS01480	COG2311	Membrane
SPBM01_RS01485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPBM01_RS01485	COG4106	trans-aconitate 2-methyltransferase activity
SPBM01_RS01490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPBM01_RS01495	COG0517	IMP dehydrogenase activity
SPBM01_RS01500	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS01510	COG1722	exodeoxyribonuclease VII activity
SPBM01_RS01515	COG0142	geranyltranstransferase activity
SPBM01_RS01520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPBM01_RS01530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPBM01_RS01555	COG0583	DNA-binding transcription factor activity
SPBM01_RS01560	COG1228	amidohydrolase
SPBM01_RS01565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPBM01_RS01580	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPBM01_RS01585	COG4771	TonB-dependent receptor
SPBM01_RS01590	COG0657	acetylesterase activity
SPBM01_RS01600	COG0657	acetylesterase activity
SPBM01_RS01600	COG2755	lipolytic protein G-D-S-L family
SPBM01_RS01615	COG3940	Belongs to the glycosyl hydrolase 43 family
SPBM01_RS01700	COG3328	transposase activity
SPBM01_RS01825	COG0484	heat shock protein binding
SPBM01_RS01915	COG0517	IMP dehydrogenase activity
SPBM01_RS01920	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS01935	COG0045	succinate-CoA ligase (ADP-forming) activity
SPBM01_RS01940	COG2086	electron transfer activity
SPBM01_RS01960	COG1278	Cold shock
SPBM01_RS01990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPBM01_RS02010	COG3279	Response regulator of the LytR AlgR family
SPBM01_RS02015	COG3275	phosphorelay sensor kinase activity
SPBM01_RS02050	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPBM01_RS02050	COG1024	Enoyl-CoA hydratase
SPBM01_RS02055	COG0183	Belongs to the thiolase family
SPBM01_RS02060	COG2814	Major facilitator Superfamily
SPBM01_RS02065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPBM01_RS02065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPBM01_RS02095	COG1024	Enoyl-CoA hydratase
SPBM01_RS02100	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS02115	COG1131	(ABC) transporter
SPBM01_RS02120	COG0842	Transport permease protein
SPBM01_RS02130	COG0534	Mate efflux family protein
SPBM01_RS02135	COG2354	Protein conserved in bacteria
SPBM01_RS02155	COG0359	binds to the 23S rRNA
SPBM01_RS02160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPBM01_RS02165	COG0360	Binds together with S18 to 16S ribosomal RNA
SPBM01_RS02170	COG2610	gluconate transmembrane transporter activity
SPBM01_RS02190	COG1136	(ABC) transporter
SPBM01_RS02190	COG0577	efflux transmembrane transporter activity
SPBM01_RS02195	COG1136	(ABC) transporter
SPBM01_RS02195	COG0577	efflux transmembrane transporter activity
SPBM01_RS02210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPBM01_RS02225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPBM01_RS02230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPBM01_RS02235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPBM01_RS02300	COG4191	Histidine kinase
SPBM01_RS02305	COG4566	intracellular signal transduction
SPBM01_RS02315	COG3300	MHYT domain
SPBM01_RS02315	COG5001	Diguanylate cyclase
SPBM01_RS02335	COG2801	Transposase and inactivated derivatives
SPBM01_RS02355	COG5001	Diguanylate cyclase
SPBM01_RS02355	COG3300	MHYT domain
SPBM01_RS02365	COG4191	Histidine kinase
SPBM01_RS02410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPBM01_RS02440	COG0640	Transcriptional regulator
SPBM01_RS02460	COG3453	Protein conserved in bacteria
SPBM01_RS02460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPBM01_RS02480	COG2308	Evidence 4 Homologs of previously reported genes of
SPBM01_RS02490	COG1305	Transglutaminase-like
SPBM01_RS02510	COG0492	ferredoxin-NADP+ reductase activity
SPBM01_RS02525	COG0318	PFAM AMP-dependent synthetase and ligase
SPBM01_RS02555	COG3267	Type II secretory pathway component ExeA
SPBM01_RS02555	COG3409	Peptidoglycan-binding domain 1 protein
SPBM01_RS02585	COG0367	asparagine synthase
SPBM01_RS02590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPBM01_RS02610	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS02630	COG2084	Dehydrogenase
SPBM01_RS02635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPBM01_RS02640	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SPBM01_RS02645	COG5001	Diguanylate cyclase
SPBM01_RS02655	COG1956	GAF domain-containing protein
SPBM01_RS02665	COG0823	Involved in the tonB-independent uptake of proteins
SPBM01_RS02665	COG4946	Tricorn protease homolog
SPBM01_RS02665	COG1506	peptidase
SPBM01_RS02675	COG1741	Belongs to the pirin family
SPBM01_RS02705	COG1595	DNA-templated transcription, initiation
SPBM01_RS02720	COG0717	Belongs to the dCTP deaminase family
SPBM01_RS02725	COG0295	cytidine deaminase activity
SPBM01_RS02730	COG3757	hydrolase, family 25
SPBM01_RS02735	COG5328	Belongs to the UPF0262 family
SPBM01_RS02740	COG0305	Participates in initiation and elongation during chromosome replication
SPBM01_RS02755	COG0175	sulfate reduction
SPBM01_RS02775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPBM01_RS02775	COG1648	precorrin-2 dehydrogenase activity
SPBM01_RS02780	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS02790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SPBM01_RS02850	COG0284	orotidine-5'-phosphate decarboxylase activity
SPBM01_RS02865	COG0477	Major facilitator Superfamily
SPBM01_RS02895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPBM01_RS02905	COG3661	Belongs to the glycosyl hydrolase 67 family
SPBM01_RS02910	COG1472	Belongs to the glycosyl hydrolase 3 family
SPBM01_RS02915	COG1472	Belongs to the glycosyl hydrolase 3 family
SPBM01_RS02920	COG4948	Mandelate Racemase Muconate Lactonizing
SPBM01_RS02925	COG2271	Major facilitator Superfamily
SPBM01_RS02930	COG1904	glucuronate isomerase
SPBM01_RS02935	COG0246	Mannitol dehydrogenase
SPBM01_RS02955	COG1522	sequence-specific DNA binding
SPBM01_RS02975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPBM01_RS02985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPBM01_RS02995	COG1610	YqeY-like protein
SPBM01_RS03000	COG0505	Belongs to the CarA family
SPBM01_RS03015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPBM01_RS03050	COG0148	phosphopyruvate hydratase activity
SPBM01_RS03060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPBM01_RS03065	COG0022	dehydrogenase e1 component
SPBM01_RS03065	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPBM01_RS03095	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SPBM01_RS03110	COG1301	dicarboxylic acid transport
SPBM01_RS03115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPBM01_RS03120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPBM01_RS03125	COG2353	YceI-like domain
SPBM01_RS03130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPBM01_RS03145	COG0028	Belongs to the TPP enzyme family
SPBM01_RS03150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPBM01_RS03155	COG0560	Phosphoserine phosphatase
SPBM01_RS03165	COG2989	Protein conserved in bacteria
SPBM01_RS03170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPBM01_RS03180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPBM01_RS03185	COG0154	amidase activity
SPBM01_RS03200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPBM01_RS03210	COG4771	TonB-dependent receptor
SPBM01_RS03230	COG0058	SHG alpha-glucan phosphorylase activity
SPBM01_RS03235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPBM01_RS03240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPBM01_RS03245	COG0297	glycogen (starch) synthase activity
SPBM01_RS03250	COG1523	belongs to the glycosyl hydrolase 13 family
SPBM01_RS03260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPBM01_RS03265	COG1573	uracil-dna glycosylase
SPBM01_RS03270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPBM01_RS03275	COG1605	Chorismate mutase
SPBM01_RS03275	COG0287	Prephenate dehydrogenase
SPBM01_RS03285	COG2827	Endonuclease containing a URI domain
SPBM01_RS03290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPBM01_RS03295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPBM01_RS03300	COG0698	ribose 5-phosphate isomerase
SPBM01_RS03310	COG2945	thiolester hydrolase activity
SPBM01_RS03315	COG1104	cysteine desulfurase activity
SPBM01_RS03330	COG2367	Beta-lactamase
SPBM01_RS03345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPBM01_RS03375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SPBM01_RS03400	COG2814	Major facilitator Superfamily
SPBM01_RS03410	COG0280	phosphate acetyltransferase
SPBM01_RS03410	COG0281	malic enzyme
SPBM01_RS03415	COG0583	DNA-binding transcription factor activity
SPBM01_RS03420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SPBM01_RS03425	COG1376	ErfK ybiS ycfS ynhG family protein
SPBM01_RS03430	COG4942	peptidase
SPBM01_RS03435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPBM01_RS03440	COG0483	inositol monophosphate 1-phosphatase activity
SPBM01_RS03445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPBM01_RS03450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPBM01_RS03455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPBM01_RS03460	COG0649	NAD binding
SPBM01_RS03470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SPBM01_RS03480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPBM01_RS03490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPBM01_RS03500	COG0713	ATP synthesis coupled electron transport
SPBM01_RS03515	COG1007	ATP synthesis coupled electron transport
SPBM01_RS03525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SPBM01_RS03540	COG0784	Response regulator, receiver
SPBM01_RS03540	COG4191	Histidine kinase
SPBM01_RS03555	COG3022	response to hydroperoxide
SPBM01_RS03570	COG4983	Phage plasmid primase, P4 family domain protein
SPBM01_RS03620	COG0772	Belongs to the SEDS family
SPBM01_RS03635	COG1792	Involved in formation and maintenance of cell shape
SPBM01_RS03645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPBM01_RS03655	COG2030	dehydratase
SPBM01_RS03655	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS03660	COG3540	Alkaline phosphatase
SPBM01_RS03670	COG0012	GTP binding
SPBM01_RS03685	COG0033	Phosphoglucomutase
SPBM01_RS03695	COG0193	aminoacyl-tRNA hydrolase activity
SPBM01_RS03700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SPBM01_RS03715	COG0752	glycyl-tRNA synthetase alpha subunit
SPBM01_RS03720	COG0751	glycine-tRNA ligase activity
SPBM01_RS03725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPBM01_RS03725	COG0574	Belongs to the PEP-utilizing enzyme family
SPBM01_RS03745	COG1492	cobalamin metabolic process
SPBM01_RS03770	COG3724	N-succinylarginine dihydrolase activity
SPBM01_RS03790	COG1051	belongs to the nudix hydrolase family
SPBM01_RS03795	COG0415	Belongs to the DNA photolyase family
SPBM01_RS03800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SPBM01_RS03805	COG4221	oxidoreductase activity
SPBM01_RS03810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPBM01_RS03820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPBM01_RS03825	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SPBM01_RS03830	COG1138	Cytochrome C-type biogenesis protein
SPBM01_RS03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPBM01_RS03840	COG3088	subunit of a heme lyase
SPBM01_RS03850	COG3158	transport of potassium into the cell
SPBM01_RS03855	COG0071	Belongs to the small heat shock protein (HSP20) family
SPBM01_RS03865	COG1136	(ABC) transporter
SPBM01_RS03880	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPBM01_RS03885	COG0741	lytic transglycosylase activity
SPBM01_RS03905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPBM01_RS03920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPBM01_RS03935	COG1748	Saccharopine dehydrogenase
SPBM01_RS03940	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SPBM01_RS03965	COG1793	dna ligase
SPBM01_RS03980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPBM01_RS03985	COG0156	8-amino-7-oxononanoate synthase activity
SPBM01_RS03990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPBM01_RS03995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SPBM01_RS04035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SPBM01_RS04250	COG4584	PFAM Integrase catalytic
SPBM01_RS04255	COG1484	DNA-dependent DNA replication
SPBM01_RS04285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPBM01_RS04285	COG1754	DNA topoisomerase type I activity
SPBM01_RS04295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPBM01_RS04300	COG0571	ribonuclease III activity
SPBM01_RS04305	COG0681	Belongs to the peptidase S26 family
SPBM01_RS04310	COG0166	Belongs to the GPI family
SPBM01_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS04325	COG0583	DNA-binding transcription factor activity
SPBM01_RS04330	COG0864	Transcriptional regulator
SPBM01_RS04340	COG1396	sequence-specific DNA binding
SPBM01_RS04340	COG3800	Transcriptional regulator
SPBM01_RS04345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPBM01_RS04350	COG0346	lactoylglutathione lyase activity
SPBM01_RS04355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPBM01_RS04355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPBM01_RS04360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPBM01_RS04370	COG4770	biotin carboxylase activity
SPBM01_RS04375	COG2890	protein-(glutamine-N5) methyltransferase activity
SPBM01_RS04380	COG0477	Major facilitator Superfamily
SPBM01_RS04385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPBM01_RS04400	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
SPBM01_RS04415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SPBM01_RS04420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SPBM01_RS04440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPBM01_RS04455	COG2267	carboxylic ester hydrolase activity
SPBM01_RS04470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPBM01_RS04480	COG1678	Uncharacterized ACR, COG1678
SPBM01_RS04485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SPBM01_RS04490	COG2205	protein histidine kinase activity
SPBM01_RS04495	COG0802	atpase or kinase
SPBM01_RS04505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPBM01_RS04515	COG1074	ATP-dependent DNA helicase activity
SPBM01_RS04525	COG0483	inositol monophosphate 1-phosphatase activity
SPBM01_RS04530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SPBM01_RS04545	COG0653	protein targeting
SPBM01_RS04565	COG2951	lytic endotransglycosylase activity
SPBM01_RS04575	COG1686	Belongs to the peptidase S11 family
SPBM01_RS04580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPBM01_RS04595	COG0084	hydrolase, TatD family'
SPBM01_RS04610	COG0477	Major facilitator Superfamily
SPBM01_RS04615	COG2801	Transposase and inactivated derivatives
SPBM01_RS04620	COG2801	Transposase and inactivated derivatives
SPBM01_RS04625	COG3956	TIGRFAM MazG family protein
SPBM01_RS04640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPBM01_RS04650	COG2204	response regulator
SPBM01_RS04655	COG5000	phosphorelay sensor kinase activity
SPBM01_RS04675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPBM01_RS04675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPBM01_RS04680	COG1546	Belongs to the CinA family
SPBM01_RS04685	COG2867	negative regulation of translational initiation
SPBM01_RS04690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPBM01_RS04900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPBM01_RS04905	COG0134	indole-3-glycerol-phosphate synthase activity
SPBM01_RS04910	COG0315	cyclic pyranopterin monophosphate synthase activity
SPBM01_RS04920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPBM01_RS04925	COG2333	competence protein COMEC
SPBM01_RS04925	COG0658	competence protein
SPBM01_RS04930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPBM01_RS04935	COG0372	Belongs to the citrate synthase family
SPBM01_RS04940	COG2205	protein histidine kinase activity
SPBM01_RS04980	COG3739	integral membrane protein
SPBM01_RS04985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SPBM01_RS04990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SPBM01_RS05005	COG3153	acetyltransferase
SPBM01_RS05010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPBM01_RS05015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SPBM01_RS05020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPBM01_RS05035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPBM01_RS05040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SPBM01_RS05160	COG2814	Major facilitator Superfamily
SPBM01_RS05225	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS05245	COG0798	PFAM Bile acid sodium symporter
SPBM01_RS05260	COG1475	DNA binding
SPBM01_RS05275	COG3916	Acyl-homoserine-lactone synthase
SPBM01_RS05285	COG1846	Transcriptional regulator
SPBM01_RS05300	COG4771	TonB-dependent receptor
SPBM01_RS05305	COG1506	peptidase
SPBM01_RS05305	COG0823	Involved in the tonB-independent uptake of proteins
SPBM01_RS05340	COG3328	transposase activity
SPBM01_RS05350	COG4771	TonB-dependent receptor
SPBM01_RS05380	COG3328	transposase activity
SPBM01_RS05520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPBM01_RS05550	COG2207	Transcriptional regulator
SPBM01_RS05550	COG1917	Cupin 2, conserved barrel domain protein
SPBM01_RS05615	COG0672	)-iron permease
SPBM01_RS05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPBM01_RS05665	COG2132	Multicopper oxidase
SPBM01_RS05685	COG2372	response to copper ion
SPBM01_RS05690	COG1276	copper resistance
SPBM01_RS05700	COG0789	Transcriptional regulator
SPBM01_RS05710	COG1230	cation diffusion facilitator family transporter
SPBM01_RS05735	COG0798	PFAM Bile acid sodium symporter
SPBM01_RS05765	COG1538	Outer membrane efflux protein
SPBM01_RS05770	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS05780	COG2066	Belongs to the glutaminase family
SPBM01_RS05785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPBM01_RS05790	COG4774	siderophore transport
SPBM01_RS05810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPBM01_RS05820	COG0436	Aminotransferase
SPBM01_RS05835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPBM01_RS05840	COG0129	dihydroxy-acid dehydratase activity
SPBM01_RS05845	COG0837	glucose binding
SPBM01_RS05850	COG0800	Aldolase
SPBM01_RS05860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SPBM01_RS05865	COG0113	porphobilinogen synthase activity
SPBM01_RS05870	COG0346	lactoylglutathione lyase activity
SPBM01_RS05890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPBM01_RS05895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPBM01_RS05920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPBM01_RS05925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPBM01_RS05930	COG1309	transcriptional regulator
SPBM01_RS05935	COG0612	Peptidase, M16
SPBM01_RS05940	COG0513	Belongs to the DEAD box helicase family
SPBM01_RS05950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SPBM01_RS05955	COG1214	PFAM Peptidase M22, glycoprotease
SPBM01_RS05960	COG0456	acetyltransferase
SPBM01_RS05960	COG1214	PFAM Peptidase M22, glycoprotease
SPBM01_RS05965	COG4957	zinc ion binding
SPBM01_RS05980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPBM01_RS05985	COG1702	phosphate starvation-inducible protein PhoH
SPBM01_RS05990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPBM01_RS05995	COG1253	flavin adenine dinucleotide binding
SPBM01_RS06010	COG0564	pseudouridine synthase activity
SPBM01_RS06015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPBM01_RS06030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SPBM01_RS06035	COG0740	serine-type endopeptidase activity
SPBM01_RS06045	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPBM01_RS06070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPBM01_RS06075	COG0004	ammonium transporteR
SPBM01_RS06085	COG0477	Major facilitator Superfamily
SPBM01_RS06095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPBM01_RS06100	COG1845	cytochrome c oxidase, subunit III
SPBM01_RS06105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SPBM01_RS06110	COG3346	SURF1 family
SPBM01_RS06120	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SPBM01_RS06130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPBM01_RS06135	COG0784	Response regulator, receiver
SPBM01_RS06135	COG4191	Histidine kinase
SPBM01_RS06160	COG1045	serine acetyltransferase
SPBM01_RS06165	COG0730	response to heat
SPBM01_RS06170	COG0583	DNA-binding transcription factor activity
SPBM01_RS06175	COG0314	molybdopterin synthase activity
SPBM01_RS06185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPBM01_RS06205	COG2081	HI0933 family
SPBM01_RS06210	COG1671	Belongs to the UPF0178 family
SPBM01_RS06220	COG0475	glutathione-regulated potassium exporter activity
SPBM01_RS06220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPBM01_RS06225	COG2363	Small membrane protein
SPBM01_RS06235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPBM01_RS06250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPBM01_RS06255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPBM01_RS06260	COG0196	riboflavin kinase activity
SPBM01_RS06275	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPBM01_RS06285	COG0588	phosphoglycerate mutase activity
SPBM01_RS06290	COG0616	signal peptide processing
SPBM01_RS06295	COG0006	proline dipeptidase activity
SPBM01_RS06300	COG0625	glutathione transferase activity
SPBM01_RS06305	COG0352	thiamine-phosphate diphosphorylase activity
SPBM01_RS06310	COG3588	fructose-bisphosphate aldolase
SPBM01_RS06315	COG0126	phosphoglycerate kinase activity
SPBM01_RS06320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPBM01_RS06340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPBM01_RS06350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPBM01_RS06365	COG0628	permease
SPBM01_RS06390	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SPBM01_RS06415	COG1058	Belongs to the CinA family
SPBM01_RS06415	COG1546	Belongs to the CinA family
SPBM01_RS06420	COG0024	Methionine aminopeptidase
SPBM01_RS06425	COG0347	Belongs to the P(II) protein family
SPBM01_RS06430	COG0174	glutamine synthetase
SPBM01_RS06440	COG0671	phosphoesterase, PA-phosphatase related
SPBM01_RS06445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPBM01_RS06450	COG1607	acyl-coa hydrolase
SPBM01_RS06455	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPBM01_RS06465	COG0557	exoribonuclease II activity
SPBM01_RS06475	COG2258	MOSC domain
SPBM01_RS06485	COG0297	glycogen (starch) synthase activity
SPBM01_RS06490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPBM01_RS06545	COG0617	tRNA 3'-terminal CCA addition
SPBM01_RS06550	COG5001	Diguanylate cyclase
SPBM01_RS06555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPBM01_RS06575	COG3387	PFAM Glycoside hydrolase 15-related
SPBM01_RS06580	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SPBM01_RS06585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPBM01_RS06600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPBM01_RS06605	COG0047	phosphoribosylformylglycinamidine synthase activity
SPBM01_RS06620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SPBM01_RS06650	COG0187	DNA topoisomerase II activity
SPBM01_RS06660	COG2860	membrane
SPBM01_RS06670	COG0386	Belongs to the glutathione peroxidase family
SPBM01_RS06680	COG0488	(ABC) transporter
SPBM01_RS06710	COG2832	Protein of unknown function (DUF454)
SPBM01_RS06740	COG1760	l-serine dehydratase
SPBM01_RS06750	COG0729	surface antigen
SPBM01_RS06795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPBM01_RS06805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPBM01_RS06810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPBM01_RS06825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPBM01_RS06865	COG0009	L-threonylcarbamoyladenylate synthase
SPBM01_RS06875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPBM01_RS06880	COG0318	PFAM AMP-dependent synthetase and ligase
SPBM01_RS06890	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS06920	COG0670	Belongs to the BI1 family
SPBM01_RS06925	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SPBM01_RS06930	COG2032	superoxide dismutase activity
SPBM01_RS06935	COG2885	chlorophyll binding
SPBM01_RS06935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPBM01_RS07030	COG4695	Portal protein
SPBM01_RS07050	COG2852	Protein conserved in bacteria
SPBM01_RS07090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPBM01_RS07095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPBM01_RS07110	COG2205	protein histidine kinase activity
SPBM01_RS07115	COG1522	sequence-specific DNA binding
SPBM01_RS07165	COG0135	phosphoribosylanthranilate isomerase activity
SPBM01_RS07170	COG0133	tryptophan synthase activity
SPBM01_RS07175	COG0159	tryptophan synthase activity
SPBM01_RS07180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPBM01_RS07185	COG0285	dihydrofolate synthase activity
SPBM01_RS07205	COG1187	pseudouridine synthase activity
SPBM01_RS07210	COG0742	ribosomal rna small subunit methyltransferase
SPBM01_RS07225	COG0210	DNA helicase
SPBM01_RS07250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPBM01_RS07260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPBM01_RS07265	COG0539	negative regulation of cytoplasmic translation
SPBM01_RS07370	COG4584	PFAM Integrase catalytic
SPBM01_RS07375	COG1484	DNA-dependent DNA replication
SPBM01_RS07485	COG0758	DNA mediated transformation
SPBM01_RS07485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPBM01_RS07730	COG0583	DNA-binding transcription factor activity
SPBM01_RS07735	COG2967	ApaG domain
SPBM01_RS07745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPBM01_RS07750	COG0473	3-isopropylmalate dehydrogenase activity
SPBM01_RS07755	COG1381	Involved in DNA repair and RecF pathway recombination
SPBM01_RS07760	COG0840	transmembrane signaling receptor activity
SPBM01_RS07770	COG0322	excinuclease ABC activity
SPBM01_RS07775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SPBM01_RS07785	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPBM01_RS07790	COG0356	it plays a direct role in the translocation of protons across the membrane
SPBM01_RS07815	COG2003	Belongs to the UPF0758 family
SPBM01_RS07820	COG0513	Belongs to the DEAD box helicase family
SPBM01_RS07830	COG0277	FAD linked oxidase domain protein
SPBM01_RS07855	COG1522	sequence-specific DNA binding
SPBM01_RS07900	COG0505	Belongs to the CarA family
SPBM01_RS07910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SPBM01_RS07920	COG1049	propionate catabolic process, 2-methylcitrate cycle
SPBM01_RS07935	COG5487	UPF0391 membrane protein
SPBM01_RS07960	COG3104	oligopeptide transport
SPBM01_RS07970	COG2188	Transcriptional regulator
SPBM01_RS07980	COG2204	response regulator
SPBM01_RS07985	COG2205	protein histidine kinase activity
SPBM01_RS07985	COG0784	Response regulator, receiver
SPBM01_RS07990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPBM01_RS08005	COG0784	Response regulator, receiver
SPBM01_RS08020	COG0343	queuine tRNA-ribosyltransferase activity
SPBM01_RS08035	COG3300	MHYT domain
SPBM01_RS08035	COG5001	Diguanylate cyclase
SPBM01_RS08040	COG0459	protein refolding
SPBM01_RS08045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPBM01_RS08050	COG0625	glutathione transferase activity
SPBM01_RS08055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPBM01_RS08070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPBM01_RS08080	COG1185	polyribonucleotide nucleotidyltransferase activity
SPBM01_RS08085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SPBM01_RS08090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPBM01_RS08100	COG1435	thymidine kinase activity
SPBM01_RS08110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPBM01_RS08115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPBM01_RS08125	COG1942	4-Oxalocrotonate Tautomerase
SPBM01_RS08135	COG0779	Required for maturation of 30S ribosomal subunits
SPBM01_RS08140	COG2133	pyrroloquinoline quinone binding
SPBM01_RS08145	COG0504	CTP synthase activity
SPBM01_RS08155	COG0149	triose-phosphate isomerase activity
SPBM01_RS08165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPBM01_RS08180	COG0457	Tetratricopeptide repeat
SPBM01_RS08220	COG0564	pseudouridine synthase activity
SPBM01_RS08240	COG2957	Belongs to the agmatine deiminase family
SPBM01_RS08255	COG0831	urea catabolic process
SPBM01_RS08260	COG0832	Belongs to the urease beta subunit family
SPBM01_RS08265	COG0804	urea catabolic process
SPBM01_RS08270	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SPBM01_RS08275	COG0830	nickel cation binding
SPBM01_RS08280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SPBM01_RS08285	COG0784	Response regulator, receiver
SPBM01_RS08285	COG5002	protein histidine kinase activity
SPBM01_RS08285	COG2198	Histidine kinase
SPBM01_RS08310	COG0833	amino acid
SPBM01_RS08315	COG0129	dihydroxy-acid dehydratase activity
SPBM01_RS08320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SPBM01_RS08325	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SPBM01_RS08330	COG3668	Plasmid stabilization system
SPBM01_RS08340	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS08350	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS08355	COG2205	protein histidine kinase activity
SPBM01_RS08360	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SPBM01_RS08365	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SPBM01_RS08370	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SPBM01_RS08500	COG1846	Transcriptional regulator
SPBM01_RS08520	COG1024	Enoyl-CoA hydratase
SPBM01_RS08540	COG0540	Belongs to the ATCase OTCase family
SPBM01_RS08545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPBM01_RS08550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPBM01_RS08555	COG0546	phosphoglycolate phosphatase activity
SPBM01_RS08560	COG1024	Enoyl-CoA hydratase
SPBM01_RS08565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPBM01_RS08575	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPBM01_RS08585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SPBM01_RS08590	COG0039	L-malate dehydrogenase activity
SPBM01_RS08595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SPBM01_RS08605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPBM01_RS08625	COG1213	nucleotidyl transferase
SPBM01_RS08665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPBM01_RS08680	COG1612	heme a metabolic process
SPBM01_RS08685	COG0800	Aldolase
SPBM01_RS08695	COG0129	dihydroxy-acid dehydratase activity
SPBM01_RS08710	COG2186	Transcriptional regulator
SPBM01_RS08755	COG1132	(ABC) transporter
SPBM01_RS08800	COG4771	TonB-dependent receptor
SPBM01_RS08825	COG3128	pkhd-type hydroxylase
SPBM01_RS08835	COG4774	siderophore transport
SPBM01_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS08850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPBM01_RS08860	COG1832	CoA-binding protein
SPBM01_RS08865	COG0489	protein tyrosine kinase activity
SPBM01_RS08870	COG0330	HflC and HflK could
SPBM01_RS08875	COG0330	HflC and HflK could
SPBM01_RS08885	COG0433	COG0433 Predicted ATPase
SPBM01_RS08895	COG2814	Major facilitator Superfamily
SPBM01_RS08910	COG0085	RNA polymerase activity
SPBM01_RS08915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPBM01_RS08935	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SPBM01_RS08955	COG0789	Transcriptional regulator
SPBM01_RS08960	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS08965	COG1295	ribonuclease BN
SPBM01_RS08980	COG0250	Participates in transcription elongation, termination and antitermination
SPBM01_RS08985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPBM01_RS08990	COG0081	regulation of translation
SPBM01_RS09000	COG4651	solute:proton antiporter activity
SPBM01_RS09000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPBM01_RS09010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPBM01_RS09015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPBM01_RS09045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPBM01_RS09050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPBM01_RS09055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPBM01_RS09075	COG1752	Esterase of the alpha-beta hydrolase superfamily
SPBM01_RS09075	COG1752	Esterase of the alpha-beta hydrolase superfamily
SPBM01_RS09085	COG2154	pterin-4-alpha-carbinolamine dehydratase
SPBM01_RS09095	COG4133	protoheme IX ABC transporter activity
SPBM01_RS09100	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPBM01_RS09110	COG1605	Chorismate mutase
SPBM01_RS09110	COG0287	Prephenate dehydrogenase
SPBM01_RS09115	COG0142	geranyltranstransferase activity
SPBM01_RS09130	COG1643	Atp-dependent helicase
SPBM01_RS09145	COG0156	8-amino-7-oxononanoate synthase activity
SPBM01_RS09165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPBM01_RS09170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPBM01_RS09175	COG0509	glycine decarboxylation via glycine cleavage system
SPBM01_RS09180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPBM01_RS09185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SPBM01_RS09195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SPBM01_RS09200	COG0849	cell division
SPBM01_RS09205	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPBM01_RS09210	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPBM01_RS09215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPBM01_RS09225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPBM01_RS09230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPBM01_RS09240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPBM01_RS09245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPBM01_RS09255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPBM01_RS09270	COG0275	rRNA processing
SPBM01_RS09290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPBM01_RS09295	COG3409	Peptidoglycan-binding domain 1 protein
SPBM01_RS09295	COG3773	Cell wall hydrolase
SPBM01_RS09305	COG0805	protein transport
SPBM01_RS09310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPBM01_RS09315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPBM01_RS09320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPBM01_RS09325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPBM01_RS09330	COG1472	Belongs to the glycosyl hydrolase 3 family
SPBM01_RS09340	COG0018	arginyl-trna synthetase
SPBM01_RS09350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPBM01_RS09355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SPBM01_RS09360	COG0328	RNA-DNA hybrid ribonuclease activity
SPBM01_RS09365	COG3422	double-strand break repair
SPBM01_RS09390	COG4964	Belongs to the GSP D family
SPBM01_RS09420	COG0242	peptide deformylase activity
SPBM01_RS09425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPBM01_RS09430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPBM01_RS09435	COG0101	tRNA pseudouridine synthase activity
SPBM01_RS09460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPBM01_RS09485	COG2885	chlorophyll binding
SPBM01_RS09490	COG2199	diguanylate cyclase activity
SPBM01_RS09500	COG2169	Transcriptional regulator
SPBM01_RS09500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPBM01_RS09510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPBM01_RS09515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SPBM01_RS09520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPBM01_RS09525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SPBM01_RS09530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPBM01_RS09545	COG0697	spore germination
SPBM01_RS09550	COG1764	response to oxidative stress
SPBM01_RS09570	COG4771	TonB-dependent receptor
SPBM01_RS09575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPBM01_RS09590	COG1160	GTP binding
SPBM01_RS09605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPBM01_RS09620	COG0534	Mate efflux family protein
SPBM01_RS09625	COG0525	valine-tRNA ligase activity
SPBM01_RS09640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SPBM01_RS09660	COG0105	UTP biosynthetic process
SPBM01_RS09670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPBM01_RS09680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPBM01_RS09685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SPBM01_RS09690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPBM01_RS09705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPBM01_RS09705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPBM01_RS09725	COG0037	tRNA processing
SPBM01_RS09735	COG1426	Protein conserved in bacteria
SPBM01_RS09745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPBM01_RS09750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPBM01_RS09775	COG5507	3-demethylubiquinone-9 3-methyltransferase
SPBM01_RS09780	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SPBM01_RS09785	COG1733	regulation of RNA biosynthetic process
SPBM01_RS09795	COG2070	2-Nitropropane dioxygenase
SPBM01_RS09805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPBM01_RS09815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPBM01_RS09830	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SPBM01_RS09845	COG5001	Diguanylate cyclase
SPBM01_RS09850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPBM01_RS09870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPBM01_RS09890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPBM01_RS09895	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SPBM01_RS09900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPBM01_RS09910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPBM01_RS09930	COG2205	protein histidine kinase activity
SPBM01_RS09960	COG1217	gtp-binding protein TYPA
SPBM01_RS09995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SPBM01_RS10005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SPBM01_RS10015	COG1530	ribonuclease E activity
SPBM01_RS10030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SPBM01_RS10035	COG0594	ribonuclease P activity
SPBM01_RS10040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPBM01_RS10045	COG0706	membrane insertase activity
SPBM01_RS10050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SPBM01_RS10055	COG2824	Alkylphosphonate utilization operon protein PhnA
SPBM01_RS10065	COG1966	Carbon starvation protein
SPBM01_RS10070	COG2879	small protein
SPBM01_RS10075	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SPBM01_RS10115	COG0693	protein deglycase activity
SPBM01_RS10135	COG4948	Mandelate Racemase Muconate Lactonizing
SPBM01_RS10140	COG1132	(ABC) transporter
SPBM01_RS10185	COG1494	fructose-1,6-bisphosphatase
SPBM01_RS10200	COG0753	catalase activity
SPBM01_RS10205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPBM01_RS10220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SPBM01_RS10230	COG3243	poly(R)-hydroxyalkanoic acid synthase
SPBM01_RS10235	COG0436	Aminotransferase
SPBM01_RS10280	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SPBM01_RS10290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPBM01_RS10290	COG1199	ATP-dependent helicase activity
SPBM01_RS10310	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS10310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPBM01_RS10360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPBM01_RS10385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPBM01_RS10390	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS10405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPBM01_RS10410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPBM01_RS10415	COG0741	lytic transglycosylase activity
SPBM01_RS10435	COG0840	transmembrane signaling receptor activity
SPBM01_RS10440	COG2326	polyphosphate kinase activity
SPBM01_RS10445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPBM01_RS10450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SPBM01_RS10470	COG1253	flavin adenine dinucleotide binding
SPBM01_RS10480	COG2095	MarC family integral membrane protein
SPBM01_RS10490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPBM01_RS10495	COG1872	DUF167
SPBM01_RS10510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPBM01_RS10525	COG0248	Ppx GppA phosphatase
SPBM01_RS10530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPBM01_RS10545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPBM01_RS10550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPBM01_RS10555	COG1131	(ABC) transporter
SPBM01_RS10560	COG2852	Protein conserved in bacteria
SPBM01_RS10570	COG2267	carboxylic ester hydrolase activity
SPBM01_RS10575	COG2367	Beta-lactamase
SPBM01_RS10580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPBM01_RS10580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPBM01_RS10590	COG0670	Belongs to the BI1 family
SPBM01_RS10595	COG0215	cysteine-tRNA ligase activity
SPBM01_RS10610	COG0488	(ABC) transporter
SPBM01_RS10615	COG3386	PFAM SMP-30 Gluconolaconase
SPBM01_RS10630	COG2186	Transcriptional regulator
SPBM01_RS10645	COG3534	alpha-L-arabinofuranosidase
SPBM01_RS10650	COG3507	Belongs to the glycosyl hydrolase 43 family
SPBM01_RS10655	COG3940	Belongs to the glycosyl hydrolase 43 family
SPBM01_RS10685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPBM01_RS10705	COG4771	TonB-dependent receptor
SPBM01_RS10710	COG0457	Tetratricopeptide repeat
SPBM01_RS10715	COG1137	ATPase activity
SPBM01_RS10720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SPBM01_RS10725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPBM01_RS10755	COG0312	modulator of DNA gyrase
SPBM01_RS10765	COG0347	Belongs to the P(II) protein family
SPBM01_RS10770	COG0004	ammonium transporteR
SPBM01_RS10800	COG1230	cation diffusion facilitator family transporter
SPBM01_RS10820	COG0514	ATP-dependent DNA helicase (RecQ)
SPBM01_RS10840	COG3273	potassium ion transport
SPBM01_RS10840	COG0471	metal ion transport
SPBM01_RS10845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SPBM01_RS10860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SPBM01_RS10865	COG1295	ribonuclease BN
SPBM01_RS10870	COG0484	heat shock protein binding
SPBM01_RS10875	COG0259	pyridoxamine-phosphate oxidase activity
SPBM01_RS10880	COG1301	dicarboxylic acid transport
SPBM01_RS10885	COG3781	membrane
SPBM01_RS10900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPBM01_RS10905	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SPBM01_RS10910	COG2852	Protein conserved in bacteria
SPBM01_RS10915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPBM01_RS10920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPBM01_RS10930	COG1611	Belongs to the LOG family
SPBM01_RS10940	COG2171	N-acyltransferase activity
SPBM01_RS10950	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS10980	COG4566	intracellular signal transduction
SPBM01_RS11010	COG1297	OPT oligopeptide transporter protein
SPBM01_RS11030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPBM01_RS11040	COG2897	thiosulfate sulfurtransferase activity
SPBM01_RS11045	COG0626	cystathionine gamma-synthase activity
SPBM01_RS11060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPBM01_RS11100	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SPBM01_RS11110	COG0109	protoheme IX farnesyltransferase activity
SPBM01_RS11115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPBM01_RS11125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPBM01_RS11130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SPBM01_RS11135	COG0736	holo-[acyl-carrier-protein] synthase activity
SPBM01_RS11140	COG0681	Belongs to the peptidase S26 family
SPBM01_RS11145	COG0628	permease
SPBM01_RS11160	COG0006	proline dipeptidase activity
SPBM01_RS11200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPBM01_RS11205	COG0583	DNA-binding transcription factor activity
SPBM01_RS11220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPBM01_RS11230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPBM01_RS11235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPBM01_RS11250	COG0072	phenylalanine-tRNA ligase activity
SPBM01_RS11255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPBM01_RS11260	COG1280	lysine exporter protein (LysE YggA)
SPBM01_RS11265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPBM01_RS11270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPBM01_RS11295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPBM01_RS11315	COG0181	hydroxymethylbilane synthase activity
SPBM01_RS11320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPBM01_RS11325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPBM01_RS11335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPBM01_RS11350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPBM01_RS11355	COG4152	abc transporter atp-binding protein
SPBM01_RS11380	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SPBM01_RS11390	COG0138	bifunctional purine biosynthesis protein purh
SPBM01_RS11435	COG0629	single-stranded DNA binding
SPBM01_RS11460	COG1902	pentaerythritol trinitrate reductase activity
SPBM01_RS11465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPBM01_RS11470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPBM01_RS11470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPBM01_RS11480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPBM01_RS11480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPBM01_RS11500	COG2733	membrane
SPBM01_RS11510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPBM01_RS11515	COG2261	transglycosylase associated protein
SPBM01_RS11520	COG2261	transglycosylase associated protein
SPBM01_RS11535	COG0482	sulfurtransferase activity
SPBM01_RS11540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPBM01_RS11545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPBM01_RS11550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPBM01_RS11565	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SPBM01_RS11585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPBM01_RS11590	COG3590	peptidase
SPBM01_RS11595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPBM01_RS11600	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPBM01_RS11605	COG0424	maF-like protein
SPBM01_RS11615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SPBM01_RS11725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPBM01_RS11745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPBM01_RS11755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPBM01_RS11790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SPBM01_RS11795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPBM01_RS11815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPBM01_RS11830	COG5001	Diguanylate cyclase
SPBM01_RS11830	COG3300	MHYT domain
SPBM01_RS11835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPBM01_RS11840	COG0287	Prephenate dehydrogenase
SPBM01_RS11860	COG2884	Cell division ATP-binding protein ftsE
SPBM01_RS11870	COG1741	Belongs to the pirin family
SPBM01_RS11890	COG0443	Heat shock 70 kDa protein
SPBM01_RS11910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPBM01_RS11915	COG0783	Belongs to the Dps family
SPBM01_RS11920	COG2119	membrane
SPBM01_RS11930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPBM01_RS11940	COG0784	Response regulator, receiver
SPBM01_RS11975	COG2814	Major facilitator Superfamily
SPBM01_RS11980	COG0531	amino acid
SPBM01_RS11985	COG1496	oxidoreductase activity
SPBM01_RS12030	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS12035	COG1024	Enoyl-CoA hydratase
SPBM01_RS12050	COG2814	Major facilitator Superfamily
SPBM01_RS12080	COG2159	amidohydrolase
SPBM01_RS12095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SPBM01_RS12105	COG3618	amidohydrolase
SPBM01_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS12130	COG1309	transcriptional regulator
SPBM01_RS12135	COG2175	clavaminate synthase activity
SPBM01_RS12140	COG3668	Plasmid stabilization system
SPBM01_RS12150	COG4638	Rieske (2fe-2S)
SPBM01_RS12160	COG0427	acetyl-CoA hydrolase
SPBM01_RS12175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS12185	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS12190	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS12200	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS12210	COG0667	Aldo Keto reductase
SPBM01_RS12220	COG0022	dehydrogenase e1 component
SPBM01_RS12225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPBM01_RS12235	COG1053	succinate dehydrogenase
SPBM01_RS12260	COG0671	phosphoesterase, PA-phosphatase related
SPBM01_RS12275	COG4221	oxidoreductase activity
SPBM01_RS12290	COG1309	transcriptional regulator
SPBM01_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS12310	COG2814	Major facilitator Superfamily
SPBM01_RS12315	COG0183	Belongs to the thiolase family
SPBM01_RS12335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS12345	COG0318	PFAM AMP-dependent synthetase and ligase
SPBM01_RS12350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS12355	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SPBM01_RS12360	COG1024	Enoyl-CoA hydratase
SPBM01_RS12405	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS12410	COG1024	Enoyl-CoA hydratase
SPBM01_RS12420	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS12455	COG0604	alcohol dehydrogenase
SPBM01_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS12510	COG1063	alcohol dehydrogenase
SPBM01_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS12535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPBM01_RS12560	COG4638	Rieske (2fe-2S)
SPBM01_RS12570	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS12575	COG2267	carboxylic ester hydrolase activity
SPBM01_RS12590	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS12610	COG1192	Involved in chromosome partitioning
SPBM01_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS12640	COG2205	protein histidine kinase activity
SPBM01_RS12695	COG4181	ATPase activity
SPBM01_RS12735	COG2132	Multicopper oxidase
SPBM01_RS12745	COG1473	amidohydrolase
SPBM01_RS12750	COG1522	sequence-specific DNA binding
SPBM01_RS12760	COG0473	3-isopropylmalate dehydrogenase activity
SPBM01_RS12805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPBM01_RS12820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPBM01_RS12875	COG4771	TonB-dependent receptor
SPBM01_RS12880	COG2271	Major facilitator Superfamily
SPBM01_RS12890	COG2272	Belongs to the type-B carboxylesterase lipase family
SPBM01_RS12895	COG0583	DNA-binding transcription factor activity
SPBM01_RS12900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPBM01_RS13135	COG1802	Transcriptional regulator
SPBM01_RS13155	COG0823	Involved in the tonB-independent uptake of proteins
SPBM01_RS13155	COG1506	peptidase
SPBM01_RS13190	COG0464	growth
SPBM01_RS13195	COG1404	Belongs to the peptidase S8 family
SPBM01_RS13220	COG3920	Histidine kinase
SPBM01_RS13245	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SPBM01_RS13255	COG1053	succinate dehydrogenase
SPBM01_RS13265	COG1053	succinate dehydrogenase
SPBM01_RS13270	COG4771	TonB-dependent receptor
SPBM01_RS13285	COG3246	L-lysine catabolic process to acetate
SPBM01_RS13295	COG1073	alpha beta
SPBM01_RS13315	COG0583	DNA-binding transcription factor activity
SPBM01_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS13330	COG2808	Putative FMN-binding domain
SPBM01_RS13370	COG4191	Histidine kinase
SPBM01_RS13370	COG0784	Response regulator, receiver
SPBM01_RS13385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPBM01_RS13410	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS13415	COG0753	catalase activity
SPBM01_RS13430	COG0590	tRNA wobble adenosine to inosine editing
SPBM01_RS13435	COG4529	Protein conserved in bacteria
SPBM01_RS13450	COG4191	Histidine kinase
SPBM01_RS13450	COG0784	Response regulator, receiver
SPBM01_RS13460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPBM01_RS13470	COG0483	inositol monophosphate 1-phosphatase activity
SPBM01_RS13505	COG0300	oxidoreductase activity
SPBM01_RS13520	COG2003	Belongs to the UPF0758 family
SPBM01_RS13565	COG4957	zinc ion binding
SPBM01_RS13725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SPBM01_RS13730	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS13745	COG0163	prenyltransferase activity
SPBM01_RS13750	COG4771	TonB-dependent receptor
SPBM01_RS13760	COG4638	Rieske (2fe-2S)
SPBM01_RS13765	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SPBM01_RS13780	COG4638	Rieske (2fe-2S)
SPBM01_RS13795	COG4638	Rieske (2fe-2S)
SPBM01_RS13800	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SPBM01_RS13830	COG3971	2-oxopent-4-enoate hydratase activity
SPBM01_RS13850	COG1942	4-Oxalocrotonate Tautomerase
SPBM01_RS13860	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS13880	COG1484	DNA-dependent DNA replication
SPBM01_RS13885	COG4584	PFAM Integrase catalytic
SPBM01_RS13885	COG2390	Transcriptional regulator
SPBM01_RS13895	COG3328	transposase activity
SPBM01_RS13900	COG3547	Transposase (IS116 IS110 IS902 family)
SPBM01_RS13915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPBM01_RS13920	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS13935	COG3547	Transposase (IS116 IS110 IS902 family)
SPBM01_RS13950	COG4584	PFAM Integrase catalytic
SPBM01_RS13955	COG1484	DNA-dependent DNA replication
SPBM01_RS13975	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SPBM01_RS13985	COG2814	Major facilitator Superfamily
SPBM01_RS13990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPBM01_RS14065	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SPBM01_RS14080	COG3328	transposase activity
SPBM01_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS14105	COG4638	Rieske (2fe-2S)
SPBM01_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS14125	COG2030	dehydratase
SPBM01_RS14135	COG0183	Belongs to the thiolase family
SPBM01_RS14140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS14155	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SPBM01_RS14160	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS14165	COG2301	Belongs to the HpcH HpaI aldolase family
SPBM01_RS14170	COG3971	2-oxopent-4-enoate hydratase activity
SPBM01_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS14190	COG1484	DNA-dependent DNA replication
SPBM01_RS14195	COG4584	PFAM Integrase catalytic
SPBM01_RS14195	COG2390	Transcriptional regulator
SPBM01_RS14200	COG3436	PFAM IS66 Orf2 family protein
SPBM01_RS14225	COG2962	Rard protein
SPBM01_RS14230	COG2962	Rard protein
SPBM01_RS14235	COG4771	TonB-dependent receptor
SPBM01_RS14250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS14260	COG3971	2-oxopent-4-enoate hydratase activity
SPBM01_RS14285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPBM01_RS14310	COG2267	carboxylic ester hydrolase activity
SPBM01_RS14320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SPBM01_RS14330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPBM01_RS14335	COG1127	ABC transporter
SPBM01_RS14385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPBM01_RS14395	COG1484	DNA-dependent DNA replication
SPBM01_RS14400	COG4584	PFAM Integrase catalytic
SPBM01_RS14415	COG1017	nitric oxide dioxygenase activity
SPBM01_RS14415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPBM01_RS14420	COG1959	2 iron, 2 sulfur cluster binding
SPBM01_RS14455	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS14460	COG4771	TonB-dependent receptor
SPBM01_RS14500	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SPBM01_RS14515	COG2186	Transcriptional regulator
SPBM01_RS14530	COG2271	Major facilitator Superfamily
SPBM01_RS14535	COG4948	Mandelate Racemase Muconate Lactonizing
SPBM01_RS14540	COG2084	Dehydrogenase
SPBM01_RS14575	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SPBM01_RS14575	COG1082	Xylose isomerase domain protein TIM barrel
SPBM01_RS14585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPBM01_RS14625	COG0513	Belongs to the DEAD box helicase family
SPBM01_RS14635	COG3220	belongs to the UPF0276 family
SPBM01_RS14645	COG4944	Protein of unknown function (DUF1109)
SPBM01_RS14690	COG2211	Major facilitator Superfamily
SPBM01_RS14705	COG1940	carbohydrate kinase activity
SPBM01_RS14735	COG2086	electron transfer activity
SPBM01_RS14740	COG2186	Transcriptional regulator
SPBM01_RS14755	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS14760	COG0583	DNA-binding transcription factor activity
SPBM01_RS14770	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS14800	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS14820	COG1309	transcriptional regulator
SPBM01_RS14825	COG4771	TonB-dependent receptor
SPBM01_RS14830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPBM01_RS14840	COG3976	FMN-binding domain protein
SPBM01_RS14840	COG0431	NADPH-dependent FMN reductase
SPBM01_RS14840	COG1053	succinate dehydrogenase
SPBM01_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS14865	COG0596	Alpha beta hydrolase
SPBM01_RS14910	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS14915	COG2124	cytochrome p450
SPBM01_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS14945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPBM01_RS14970	COG4221	oxidoreductase activity
SPBM01_RS14975	COG2130	NADP-dependent
SPBM01_RS14985	COG4993	Dehydrogenase
SPBM01_RS15030	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS15050	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPBM01_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15070	COG0183	Belongs to the thiolase family
SPBM01_RS15075	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPBM01_RS15075	COG1024	Enoyl-CoA hydratase
SPBM01_RS15080	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS15085	COG2030	dehydratase
SPBM01_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15105	COG0604	alcohol dehydrogenase
SPBM01_RS15120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS15125	COG4771	TonB-dependent receptor
SPBM01_RS15130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPBM01_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15150	COG1053	succinate dehydrogenase
SPBM01_RS15170	COG1309	transcriptional regulator
SPBM01_RS15190	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15200	COG2365	Tyrosine phosphatase family
SPBM01_RS15230	COG2814	Major facilitator Superfamily
SPBM01_RS15245	COG2271	Major facilitator Superfamily
SPBM01_RS15255	COG4771	TonB-dependent receptor
SPBM01_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15285	COG4529	Protein conserved in bacteria
SPBM01_RS15290	COG0753	catalase activity
SPBM01_RS15300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SPBM01_RS15310	COG3186	Phenylalanine-4-hydroxylase
SPBM01_RS15315	COG1522	sequence-specific DNA binding
SPBM01_RS15330	COG4771	TonB-dependent receptor
SPBM01_RS15335	COG0366	Alpha amylase catalytic
SPBM01_RS15350	COG3250	beta-galactosidase activity
SPBM01_RS15355	COG0673	inositol 2-dehydrogenase activity
SPBM01_RS15375	COG0642	Histidine kinase
SPBM01_RS15380	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS15395	COG2851	Citrate transporter
SPBM01_RS15405	COG0861	Integral membrane protein TerC family
SPBM01_RS15415	COG0477	Major facilitator Superfamily
SPBM01_RS15445	COG0583	DNA-binding transcription factor activity
SPBM01_RS15450	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS15455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPBM01_RS15460	COG2852	Protein conserved in bacteria
SPBM01_RS15470	COG2030	dehydratase
SPBM01_RS15495	COG0583	DNA-binding transcription factor activity
SPBM01_RS15500	COG1082	Xylose isomerase domain protein TIM barrel
SPBM01_RS15500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SPBM01_RS15510	COG0657	acetylesterase activity
SPBM01_RS15530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SPBM01_RS15535	COG2271	Major facilitator Superfamily
SPBM01_RS15540	COG4206	TonB-dependent receptor
SPBM01_RS15545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPBM01_RS15550	COG0339	signal peptide processing
SPBM01_RS15560	COG0657	acetylesterase activity
SPBM01_RS15570	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15575	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15580	COG2721	sulfolactate sulfo-lyase activity
SPBM01_RS15585	COG2271	Major facilitator Superfamily
SPBM01_RS15595	COG1609	Transcriptional regulator
SPBM01_RS15600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SPBM01_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS15610	COG2272	Belongs to the type-B carboxylesterase lipase family
SPBM01_RS15625	COG1538	Outer membrane efflux protein
SPBM01_RS15660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SPBM01_RS15665	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SPBM01_RS15675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SPBM01_RS15685	COG0778	Nitroreductase
SPBM01_RS15700	COG1797	cobyrinic acid a,c-diamide synthase activity
SPBM01_RS15705	COG2875	Belongs to the precorrin methyltransferase family
SPBM01_RS15720	COG2099	Precorrin-6x reductase
SPBM01_RS15755	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPBM01_RS15760	COG4771	TonB-dependent receptor
SPBM01_RS15770	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS15775	COG0183	Belongs to the thiolase family
SPBM01_RS15785	COG1024	Enoyl-CoA hydratase
SPBM01_RS15790	COG0183	Belongs to the thiolase family
SPBM01_RS15800	COG1082	Xylose isomerase domain protein TIM barrel
SPBM01_RS15805	COG0366	Alpha amylase catalytic
SPBM01_RS15830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPBM01_RS15850	COG3474	cytochrome
SPBM01_RS15855	COG0024	Methionine aminopeptidase
SPBM01_RS15865	COG2801	Transposase and inactivated derivatives
SPBM01_RS15875	COG0318	PFAM AMP-dependent synthetase and ligase
SPBM01_RS15880	COG3507	Belongs to the glycosyl hydrolase 43 family
SPBM01_RS15900	COG0776	regulation of translation
SPBM01_RS15915	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
SPBM01_RS15920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPBM01_RS15970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPBM01_RS15975	COG0784	Response regulator, receiver
SPBM01_RS15975	COG2205	protein histidine kinase activity
SPBM01_RS15975	COG5002	protein histidine kinase activity
SPBM01_RS15980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SPBM01_RS15985	COG3920	Histidine kinase
SPBM01_RS16005	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS16015	COG2124	cytochrome p450
SPBM01_RS16020	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS16030	COG2130	NADP-dependent
SPBM01_RS16035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS16040	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SPBM01_RS16045	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS16050	COG0183	Belongs to the thiolase family
SPBM01_RS16075	COG1024	Enoyl-CoA hydratase
SPBM01_RS16090	COG0183	Belongs to the thiolase family
SPBM01_RS16100	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPBM01_RS16115	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SPBM01_RS16130	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS16135	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS16140	COG2814	Major facilitator Superfamily
SPBM01_RS16145	COG0318	PFAM AMP-dependent synthetase and ligase
SPBM01_RS16155	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPBM01_RS16155	COG1024	Enoyl-CoA hydratase
SPBM01_RS16180	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SPBM01_RS16190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPBM01_RS16195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPBM01_RS16215	COG2272	Belongs to the type-B carboxylesterase lipase family
SPBM01_RS16220	COG1024	Enoyl-CoA hydratase
SPBM01_RS16225	COG2301	Belongs to the HpcH HpaI aldolase family
SPBM01_RS16230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SPBM01_RS16240	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPBM01_RS16270	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS16295	COG5002	protein histidine kinase activity
SPBM01_RS16305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPBM01_RS16320	COG1621	beta-fructofuranosidase activity
SPBM01_RS16325	COG1940	carbohydrate kinase activity
SPBM01_RS16330	COG0475	glutathione-regulated potassium exporter activity
SPBM01_RS16360	COG2211	Major facilitator Superfamily
SPBM01_RS16365	COG0405	Gamma-glutamyltransferase
SPBM01_RS16370	COG4206	TonB-dependent receptor
SPBM01_RS16380	COG0823	Involved in the tonB-independent uptake of proteins
SPBM01_RS16385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPBM01_RS16395	COG0251	oxidation-reduction process
SPBM01_RS16400	COG1335	isochorismatase
SPBM01_RS16415	COG0798	PFAM Bile acid sodium symporter
SPBM01_RS16420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPBM01_RS16430	COG1116	anion transmembrane transporter activity
SPBM01_RS16435	COG3046	protein related to deoxyribodipyrimidine photolyase
SPBM01_RS16450	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
SPBM01_RS16465	COG4946	Tricorn protease homolog
SPBM01_RS16465	COG0823	Involved in the tonB-independent uptake of proteins
SPBM01_RS16465	COG1506	peptidase
SPBM01_RS16470	COG3250	beta-galactosidase activity
SPBM01_RS16475	COG1162	GTPase activity
SPBM01_RS16490	COG3547	Transposase (IS116 IS110 IS902 family)
SPBM01_RS16530	COG3328	transposase activity
SPBM01_RS16540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPBM01_RS16545	COG4584	PFAM Integrase catalytic
SPBM01_RS16550	COG1484	DNA-dependent DNA replication
SPBM01_RS16570	COG4584	PFAM Integrase catalytic
SPBM01_RS16575	COG1484	DNA-dependent DNA replication
SPBM01_RS16580	COG3436	PFAM IS66 Orf2 family protein
SPBM01_RS16640	COG3012	SEC-C Motif Domain Protein
SPBM01_RS16645	COG4372	Transposase
SPBM01_RS16650	COG3436	PFAM IS66 Orf2 family protein
SPBM01_RS16670	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS16685	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS16730	COG1132	(ABC) transporter
SPBM01_RS16735	COG0438	transferase activity, transferring glycosyl groups
SPBM01_RS16815	COG0489	protein tyrosine kinase activity
SPBM01_RS16815	COG3206	protein involved in exopolysaccharide biosynthesis
SPBM01_RS16830	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS16835	COG0517	IMP dehydrogenase activity
SPBM01_RS16845	COG1484	DNA-dependent DNA replication
SPBM01_RS16850	COG4584	PFAM Integrase catalytic
SPBM01_RS16855	COG4372	Transposase
SPBM01_RS16860	COG3436	PFAM IS66 Orf2 family protein
SPBM01_RS16865	COG4584	PFAM Integrase catalytic
SPBM01_RS16870	COG1484	DNA-dependent DNA replication
SPBM01_RS16875	COG3436	PFAM IS66 Orf2 family protein
SPBM01_RS16905	COG4467	Involved in initiation control of chromosome replication
SPBM01_RS17005	COG4372	Transposase
SPBM01_RS17010	COG3436	PFAM IS66 Orf2 family protein
SPBM01_RS17035	COG1802	Transcriptional regulator
SPBM01_RS17045	COG0300	oxidoreductase activity
SPBM01_RS17060	COG2223	nitrite transmembrane transporter activity
SPBM01_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS17105	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS17110	COG1733	regulation of RNA biosynthetic process
SPBM01_RS17120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPBM01_RS17125	COG3119	arylsulfatase activity
SPBM01_RS17130	COG4771	TonB-dependent receptor
SPBM01_RS17135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPBM01_RS17140	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS17145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPBM01_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS17160	COG2814	Major facilitator Superfamily
SPBM01_RS17180	COG3158	transport of potassium into the cell
SPBM01_RS17195	COG1609	Transcriptional regulator
SPBM01_RS17220	COG0385	Bile acid
SPBM01_RS17230	COG2252	PERMEase
SPBM01_RS17235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPBM01_RS17250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPBM01_RS17270	COG2072	flavoprotein involved in K transport
SPBM01_RS17285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPBM01_RS17290	COG3608	succinylglutamate desuccinylase aspartoacylase
SPBM01_RS17290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SPBM01_RS17295	COG0402	S-adenosylhomocysteine deaminase activity
SPBM01_RS17320	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SPBM01_RS17325	COG0583	DNA-binding transcription factor activity
SPBM01_RS17330	COG4774	siderophore transport
SPBM01_RS17450	COG1309	transcriptional regulator
SPBM01_RS17460	COG1024	Enoyl-CoA hydratase
SPBM01_RS17465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPBM01_RS17475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPBM01_RS17475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPBM01_RS17500	COG1024	Enoyl-CoA hydratase
SPBM01_RS17515	COG4771	TonB-dependent receptor
SPBM01_RS17525	COG0517	IMP dehydrogenase activity
SPBM01_RS17535	COG0123	including yeast histone deacetylase and acetoin utilization protein
SPBM01_RS17565	COG2207	Transcriptional regulator
SPBM01_RS17570	COG4771	TonB-dependent receptor
SPBM01_RS17575	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS17585	COG0318	PFAM AMP-dependent synthetase and ligase
SPBM01_RS17605	COG1024	Enoyl-CoA hydratase
SPBM01_RS17620	COG1960	acyl-CoA dehydrogenase activity
SPBM01_RS17625	COG1063	alcohol dehydrogenase
SPBM01_RS17650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPBM01_RS17665	COG3609	addiction module antidote protein, CC2985 family
SPBM01_RS17695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPBM01_RS17700	COG4584	PFAM Integrase catalytic
SPBM01_RS17705	COG1484	DNA-dependent DNA replication
SPBM01_RS17745	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS17810	COG2244	polysaccharide biosynthetic process
SPBM01_RS17815	COG0517	IMP dehydrogenase activity
SPBM01_RS17845	COG2890	protein-(glutamine-N5) methyltransferase activity
SPBM01_RS17850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPBM01_RS17855	COG0124	histidyl-tRNA synthetase
SPBM01_RS17865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SPBM01_RS17870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPBM01_RS17875	COG2364	Membrane
SPBM01_RS17910	COG0753	catalase activity
SPBM01_RS17915	COG1201	RNA secondary structure unwinding
SPBM01_RS17925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPBM01_RS17935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPBM01_RS17940	COG1127	ABC transporter
SPBM01_RS17955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SPBM01_RS17960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPBM01_RS17965	COG0280	phosphate acetyltransferase
SPBM01_RS17965	COG0281	malic enzyme
SPBM01_RS18000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPBM01_RS18020	COG0308	aminopeptidase N
SPBM01_RS18035	COG0357	Ribosomal RNA small subunit methyltransferase G
SPBM01_RS18040	COG0445	tRNA wobble uridine modification
SPBM01_RS18045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPBM01_RS18065	COG0861	Integral membrane protein TerC family
SPBM01_RS18070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SPBM01_RS18085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPBM01_RS18090	COG0644	oxidoreductase
SPBM01_RS18115	COG0495	leucyl-tRNA aminoacylation
SPBM01_RS18140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPBM01_RS18145	COG4771	TonB-dependent receptor
SPBM01_RS18165	COG2983	Belongs to the UPF0260 family
SPBM01_RS18170	COG1999	signal sequence binding
SPBM01_RS18200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPBM01_RS18205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SPBM01_RS18210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPBM01_RS18215	COG0237	dephospho-CoA kinase activity
SPBM01_RS18220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPBM01_RS18225	COG0424	maF-like protein
SPBM01_RS18230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPBM01_RS18235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPBM01_RS18240	COG1981	membrane
SPBM01_RS18245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SPBM01_RS18250	COG1192	Involved in chromosome partitioning
SPBM01_RS18265	COG2067	long-chain fatty acid transport protein
SPBM01_RS18270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPBM01_RS18310	COG0483	inositol monophosphate 1-phosphatase activity
SPBM01_RS18315	COG0312	modulator of DNA gyrase
SPBM01_RS18325	COG1194	a g-specific adenine glycosylase
SPBM01_RS18360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPBM01_RS18400	COG0632	four-way junction helicase activity
SPBM01_RS18410	COG2255	four-way junction helicase activity
SPBM01_RS18425	COG2801	Transposase and inactivated derivatives
SPBM01_RS18440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPBM01_RS18465	COG2267	carboxylic ester hydrolase activity
SPBM01_RS18475	COG0582	viral genome integration into host DNA
SPBM01_RS18495	COG1484	DNA-dependent DNA replication
SPBM01_RS18500	COG4584	PFAM Integrase catalytic
SPBM01_RS18530	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SPBM01_RS18560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPBM01_RS18560	COG3743	rRNA binding
SPBM01_RS18565	COG0151	Belongs to the GarS family
SPBM01_RS18570	COG1570	exodeoxyribonuclease VII activity
SPBM01_RS18590	COG4206	TonB-dependent receptor
SPBM01_RS18610	COG0542	response to heat
SPBM01_RS18620	COG0612	Peptidase, M16
SPBM01_RS18630	COG1846	Transcriptional regulator
SPBM01_RS18670	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS18675	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SPBM01_RS18685	COG1139	Iron-sulfur cluster binding protein
SPBM01_RS18690	COG0247	lactate metabolic process
SPBM01_RS18695	COG0657	acetylesterase activity
SPBM01_RS18695	COG2755	lipolytic protein G-D-S-L family
SPBM01_RS18700	COG2755	lipolytic protein G-D-S-L family
SPBM01_RS18710	COG1414	Transcriptional regulator
SPBM01_RS18715	COG4948	Mandelate Racemase Muconate Lactonizing
SPBM01_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
SPBM01_RS18730	COG3618	amidohydrolase
SPBM01_RS18750	COG1609	Transcriptional regulator
SPBM01_RS18770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SPBM01_RS18780	COG3254	rhamnose metabolic process
SPBM01_RS18790	COG2755	lipolytic protein G-D-S-L family
SPBM01_RS18805	COG1414	Transcriptional regulator
SPBM01_RS18810	COG2885	chlorophyll binding
SPBM01_RS18815	COG0823	Involved in the tonB-independent uptake of proteins
SPBM01_RS18835	COG0824	Thioesterase
SPBM01_RS18840	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPBM01_RS18845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SPBM01_RS18855	COG1842	Phage shock protein A
SPBM01_RS18900	COG0405	Gamma-glutamyltransferase
SPBM01_RS18905	COG0167	dihydroorotate dehydrogenase activity
SPBM01_RS18920	COG0719	Fe-S assembly protein
SPBM01_RS18940	COG0396	ATPase activity
SPBM01_RS18945	COG0719	Fe-S assembly protein
SPBM01_RS18950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPBM01_RS18955	COG2151	metal-sulfur cluster biosynthetic enzyme
SPBM01_RS18960	COG0316	Belongs to the HesB IscA family
SPBM01_RS18985	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SPBM01_RS18995	COG0793	Belongs to the peptidase S41A family
SPBM01_RS19005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SPBM01_RS19010	COG0799	negative regulation of ribosome biogenesis
SPBM01_RS19015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPBM01_RS19030	COG2202	Pas domain
SPBM01_RS19030	COG2205	protein histidine kinase activity
SPBM01_RS19045	COG1012	belongs to the aldehyde dehydrogenase family
SPBM01_RS19055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPBM01_RS19060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SPBM01_RS19065	COG2080	2 iron, 2 sulfur cluster binding
SPBM01_RS19145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SPBM01_RS19145	COG2755	lipolytic protein G-D-S-L family
SPBM01_RS19190	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS19195	COG5265	(ABC) transporter
SPBM01_RS19205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPBM01_RS19205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPBM01_RS19250	COG0556	nucleotide-excision repair
SPBM01_RS19275	COG1393	Belongs to the ArsC family
SPBM01_RS19280	COG0584	glycerophosphoryl diester phosphodiesterase
SPBM01_RS19285	COG1959	2 iron, 2 sulfur cluster binding
SPBM01_RS19290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPBM01_RS19300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SPBM01_RS19305	COG0416	fatty acid biosynthetic process
SPBM01_RS19310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPBM01_RS19315	COG0776	regulation of translation
SPBM01_RS19320	COG1609	Transcriptional regulator
SPBM01_RS19325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPBM01_RS19345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPBM01_RS19370	COG2239	Acts as a magnesium transporter
SPBM01_RS19410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SPBM01_RS19415	COG0545	Peptidyl-prolyl cis-trans isomerase
SPBM01_RS19445	COG1968	undecaprenyl-diphosphatase activity
SPBM01_RS19455	COG2119	membrane
SPBM01_RS19470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPBM01_RS19480	COG1862	Preprotein translocase
SPBM01_RS19510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPBM01_RS19515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPBM01_RS19520	COG0202	RNA polymerase activity
SPBM01_RS19525	COG0203	ribosomal protein L17
SPBM01_RS19530	COG1505	serine-type exopeptidase activity
SPBM01_RS19545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPBM01_RS19545	COG0519	Catalyzes the synthesis of GMP from XMP
SPBM01_RS19595	COG1322	Protein conserved in bacteria
SPBM01_RS19615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPBM01_RS19620	COG0564	pseudouridine synthase activity
SPBM01_RS19630	COG0546	phosphoglycolate phosphatase activity
SPBM01_RS19660	COG2989	Protein conserved in bacteria
SPBM01_RS19665	COG2201	protein-glutamate methylesterase activity
SPBM01_RS19685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPBM01_RS19725	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SPBM01_RS19730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPBM01_RS19745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPBM01_RS19750	COG2814	Major facilitator Superfamily
SPBM01_RS19755	COG4771	TonB-dependent receptor
SPBM01_RS19765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPBM01_RS19765	COG2813	Specifically methylates the guanine in position
SPBM01_RS19770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPBM01_RS19775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPBM01_RS19785	COG0140	phosphoribosyl-ATP diphosphatase activity
SPBM01_RS19795	COG0107	imidazoleglycerol-phosphate synthase activity
SPBM01_RS19800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPBM01_RS19805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SPBM01_RS19810	COG0131	Imidazoleglycerol-phosphate dehydratase
SPBM01_RS19825	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SPBM01_RS19830	COG0114	fumarate hydratase activity
SPBM01_RS19845	COG0194	GDP metabolic process
SPBM01_RS19855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPBM01_RS19865	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SPBM01_RS20010	COG0739	heme binding
SPBM01_RS20015	COG5001	Diguanylate cyclase
SPBM01_RS20020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPBM01_RS20025	COG0049	tRNA binding
SPBM01_RS20030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPBM01_RS20035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPBM01_RS20040	COG0051	transcription antitermination factor activity, RNA binding
SPBM01_RS20045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPBM01_RS20050	COG0088	Forms part of the polypeptide exit tunnel
SPBM01_RS20055	COG0089	rRNA binding
SPBM01_RS20060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPBM01_RS20065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPBM01_RS20070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPBM01_RS20075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPBM01_RS20080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPBM01_RS20085	COG0255	Belongs to the universal ribosomal protein uL29 family
SPBM01_RS20090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPBM01_RS20095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPBM01_RS20100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SPBM01_RS20105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPBM01_RS20110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPBM01_RS20115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPBM01_RS20120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPBM01_RS20125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SPBM01_RS20130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPBM01_RS20135	COG1841	ribosomal large subunit assembly
SPBM01_RS20140	COG0200	Binds to the 23S rRNA
SPBM01_RS20145	COG0201	protein transport
SPBM01_RS20150	COG0563	adenylate kinase activity
SPBM01_RS20170	COG0481	GTPase activity
SPBM01_RS20205	COG2850	peptidyl-arginine hydroxylation
SPBM01_RS20220	COG0517	IMP dehydrogenase activity
SPBM01_RS20225	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS20240	COG0517	IMP dehydrogenase activity
SPBM01_RS20245	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS20250	COG3474	cytochrome
SPBM01_RS20255	COG1605	Chorismate mutase
SPBM01_RS20255	COG0077	Prephenate dehydratase
SPBM01_RS20275	COG3118	belongs to the thioredoxin family
SPBM01_RS20280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SPBM01_RS20285	COG2835	tetraacyldisaccharide 4'-kinase activity
SPBM01_RS20305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPBM01_RS20315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPBM01_RS20320	COG0165	Argininosuccinate lyase
SPBM01_RS20330	COG0019	diaminopimelate decarboxylase activity
SPBM01_RS20335	COG1648	precorrin-2 dehydrogenase activity
SPBM01_RS20335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPBM01_RS20360	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS20370	COG1538	Outer membrane efflux protein
SPBM01_RS20380	COG2814	Major facilitator Superfamily
SPBM01_RS20385	COG3707	response regulator
SPBM01_RS20390	COG1116	anion transmembrane transporter activity
SPBM01_RS20390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPBM01_RS20395	COG2223	nitrite transmembrane transporter activity
SPBM01_RS20405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPBM01_RS20415	COG0243	molybdopterin cofactor binding
SPBM01_RS20420	COG1648	precorrin-2 dehydrogenase activity
SPBM01_RS20420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPBM01_RS20425	COG0746	molybdenum cofactor guanylyltransferase activity
SPBM01_RS20435	COG4206	TonB-dependent receptor
SPBM01_RS20445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPBM01_RS20450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SPBM01_RS20460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPBM01_RS20465	COG0792	nuclease activity
SPBM01_RS20470	COG0189	ligase activity
SPBM01_RS20475	COG0586	Pfam SNARE associated Golgi protein
SPBM01_RS20485	COG4974	Belongs to the 'phage' integrase family
SPBM01_RS20500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SPBM01_RS20520	COG4166	transmembrane transport
SPBM01_RS20525	COG3746	phosphate-selective porin O and P
SPBM01_RS20530	COG2205	protein histidine kinase activity
SPBM01_RS20535	COG0745	RESPONSE REGULATOR receiver
SPBM01_RS20540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPBM01_RS20560	COG2301	Belongs to the HpcH HpaI aldolase family
SPBM01_RS20565	COG0243	molybdopterin cofactor binding
SPBM01_RS20615	COG1522	sequence-specific DNA binding
SPBM01_RS20620	COG0686	Belongs to the AlaDH PNT family
SPBM01_RS20625	COG0730	response to heat
SPBM01_RS20635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPBM01_RS20675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SPBM01_RS20705	COG1278	Cold shock
SPBM01_RS20715	COG3781	membrane
SPBM01_RS20720	COG1396	sequence-specific DNA binding
SPBM01_RS20720	COG3800	Transcriptional regulator
SPBM01_RS20730	COG0306	phosphate transporter
SPBM01_RS20735	COG1392	Phosphate transport regulator
SPBM01_RS20740	COG4206	TonB-dependent receptor
SPBM01_RS20745	COG0583	DNA-binding transcription factor activity
SPBM01_RS20750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPBM01_RS20755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPBM01_RS20760	COG3959	Transketolase, thiamine diphosphate binding domain
SPBM01_RS20765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPBM01_RS20770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPBM01_RS20790	COG0463	Glycosyl transferase, family 2
SPBM01_RS20825	COG0137	argininosuccinate synthase activity
SPBM01_RS20840	COG2205	protein histidine kinase activity
SPBM01_RS20845	COG1360	Flagellar Motor Protein
SPBM01_RS20870	COG1706	bacterial-type flagellum-dependent cell motility
SPBM01_RS20875	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SPBM01_RS20885	COG4787	bacterial-type flagellum-dependent cell motility
SPBM01_RS20890	COG4786	Flagellar basal body rod
SPBM01_RS20900	COG1558	bacterial-type flagellum-dependent cell motility
SPBM01_RS20910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SPBM01_RS20940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SPBM01_RS20970	COG1677	Flagellar hook-basal body complex protein FliE
SPBM01_RS20980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SPBM01_RS21030	COG1987	bacterial-type flagellum assembly
SPBM01_RS21040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SPBM01_RS21065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPBM01_RS21070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPBM01_RS21085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SPBM01_RS21090	COG0602	queuosine metabolic process
SPBM01_RS21105	COG0321	lipoyl(octanoyl) transferase activity
SPBM01_RS21120	COG0408	coproporphyrinogen oxidase activity
SPBM01_RS21125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SPBM01_RS21145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPBM01_RS21155	COG3328	transposase activity
SPBM01_RS21160	COG3547	Transposase (IS116 IS110 IS902 family)
SPBM01_RS21165	COG4584	PFAM Integrase catalytic
SPBM01_RS21170	COG1484	DNA-dependent DNA replication
SPBM01_RS21190	COG1301	dicarboxylic acid transport
SPBM01_RS21205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SPBM01_RS21205	COG2755	lipolytic protein G-D-S-L family
SPBM01_RS21210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SPBM01_RS21215	COG1253	flavin adenine dinucleotide binding
SPBM01_RS21225	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SPBM01_RS21250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPBM01_RS21255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPBM01_RS21270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPBM01_RS21280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPBM01_RS21285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPBM01_RS21300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPBM01_RS21310	COG0756	dUTP diphosphatase activity
SPBM01_RS21315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPBM01_RS21330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SPBM01_RS21335	COG2226	methyltransferase
SPBM01_RS21340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPBM01_RS21345	COG0268	Binds directly to 16S ribosomal RNA
SPBM01_RS21355	COG3002	Belongs to the UPF0753 family
SPBM01_RS21360	COG2274	protein secretion by the type I secretion system
SPBM01_RS21390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPBM01_RS21405	COG0288	reversible hydration of carbon dioxide
SPBM01_RS21425	COG3093	addiction module antidote protein HigA
SPBM01_RS21430	COG4691	Plasmid stability protein
SPBM01_RS21435	COG1487	ribonuclease activity
SPBM01_RS21450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SPBM01_RS21460	COG0489	protein tyrosine kinase activity
SPBM01_RS21550	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SPBM01_RS21555	COG2948	multi-organism process
SPBM01_RS21560	COG3504	Conjugal transfer protein
SPBM01_RS21585	COG3451	type IV secretory pathway VirB4
SPBM01_RS21625	COG3620	sequence-specific DNA binding
SPBM01_RS21655	COG4227	nucleotidyltransferase activity
SPBM01_RS21705	COG0583	DNA-binding transcription factor activity