locus-tag	class	description
E5554_RS00010	COG2239	Acts as a magnesium transporter
E5554_RS00040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5554_RS00050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5554_RS00060	COG1741	Belongs to the pirin family
E5554_RS00070	COG1741	Belongs to the pirin family
E5554_RS00075	COG0583	DNA-binding transcription factor activity
E5554_RS00080	COG2319	Wd-40 repeat
E5554_RS00105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5554_RS00130	COG3534	alpha-L-arabinofuranosidase
E5554_RS00155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5554_RS00160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5554_RS00165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5554_RS00165	COG2813	Specifically methylates the guanine in position
E5554_RS00180	COG0300	oxidoreductase activity
E5554_RS00200	COG0741	lytic transglycosylase activity
E5554_RS00205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5554_RS00210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5554_RS00225	COG0745	RESPONSE REGULATOR receiver
E5554_RS00230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5554_RS00240	COG0840	transmembrane signaling receptor activity
E5554_RS00245	COG2326	polyphosphate kinase activity
E5554_RS00255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5554_RS00260	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E5554_RS00315	COG0481	GTPase activity
E5554_RS00325	COG0563	adenylate kinase activity
E5554_RS00330	COG0201	protein transport
E5554_RS00335	COG0200	Binds to the 23S rRNA
E5554_RS00340	COG1841	ribosomal large subunit assembly
E5554_RS00345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5554_RS00350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5554_RS00355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5554_RS00360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5554_RS00365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5554_RS00370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5554_RS00375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5554_RS00380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5554_RS00385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5554_RS00390	COG0255	Belongs to the universal ribosomal protein uL29 family
E5554_RS00395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5554_RS00400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5554_RS00405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5554_RS00410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5554_RS00415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5554_RS00420	COG0089	rRNA binding
E5554_RS00425	COG0088	Forms part of the polypeptide exit tunnel
E5554_RS00430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5554_RS00435	COG0051	transcription antitermination factor activity, RNA binding
E5554_RS00440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5554_RS00445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5554_RS00450	COG0049	tRNA binding
E5554_RS00455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5554_RS00460	COG5001	Diguanylate cyclase
E5554_RS00460	COG3300	MHYT domain
E5554_RS00465	COG0739	heme binding
E5554_RS00480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5554_RS00515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5554_RS00520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5554_RS00525	COG1862	Preprotein translocase
E5554_RS00570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5554_RS00575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5554_RS00580	COG0202	RNA polymerase activity
E5554_RS00585	COG0203	ribosomal protein L17
E5554_RS00590	COG1505	serine-type exopeptidase activity
E5554_RS00605	COG2268	Band 7 protein
E5554_RS00635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5554_RS00645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5554_RS00650	COG3590	peptidase
E5554_RS00665	COG2885	chlorophyll binding
E5554_RS00670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5554_RS00675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5554_RS00680	COG0424	maF-like protein
E5554_RS00690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5554_RS00700	COG0582	viral genome integration into host DNA
E5554_RS00710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5554_RS00745	COG0071	Belongs to the small heat shock protein (HSP20) family
E5554_RS00750	COG0071	Belongs to the small heat shock protein (HSP20) family
E5554_RS00795	COG0784	Response regulator, receiver
E5554_RS00795	COG4191	Histidine kinase
E5554_RS00820	COG3220	belongs to the UPF0276 family
E5554_RS00830	COG4944	Protein of unknown function (DUF1109)
E5554_RS00885	COG3001	Fructosamine kinase
E5554_RS00920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5554_RS00950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5554_RS00970	COG4221	oxidoreductase activity
E5554_RS00985	COG0582	viral genome integration into host DNA
E5554_RS00995	COG4774	siderophore transport
E5554_RS01005	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E5554_RS01010	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E5554_RS01015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5554_RS01020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5554_RS01025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5554_RS01035	COG0482	sulfurtransferase activity
E5554_RS01055	COG2261	transglycosylase associated protein
E5554_RS01060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5554_RS01070	COG2733	membrane
E5554_RS01090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5554_RS01090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5554_RS01105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5554_RS01110	COG1902	pentaerythritol trinitrate reductase activity
E5554_RS01135	COG0629	single-stranded DNA binding
E5554_RS01140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5554_RS01160	COG0501	Belongs to the peptidase M48B family
E5554_RS01195	COG4946	Tricorn protease homolog
E5554_RS01195	COG1506	peptidase
E5554_RS01195	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS01200	COG0138	bifunctional purine biosynthesis protein purh
E5554_RS01235	COG4152	abc transporter atp-binding protein
E5554_RS01240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5554_RS01255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5554_RS01265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5554_RS01270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5554_RS01275	COG0181	hydroxymethylbilane synthase activity
E5554_RS01300	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E5554_RS01300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5554_RS01340	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E5554_RS01355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5554_RS01360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5554_RS01365	COG1280	lysine exporter protein (LysE YggA)
E5554_RS01370	COG2827	Endonuclease containing a URI domain
E5554_RS01375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5554_RS01380	COG0072	phenylalanine-tRNA ligase activity
E5554_RS01400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5554_RS01405	COG2814	Major facilitator Superfamily
E5554_RS01410	COG4771	TonB-dependent receptor
E5554_RS01425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5554_RS01430	COG0287	Prephenate dehydrogenase
E5554_RS01450	COG2884	Cell division ATP-binding protein ftsE
E5554_RS01460	COG1741	Belongs to the pirin family
E5554_RS01495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5554_RS01500	COG0783	Belongs to the Dps family
E5554_RS01515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5554_RS01525	COG0784	Response regulator, receiver
E5554_RS01560	COG2814	Major facilitator Superfamily
E5554_RS01575	COG0531	amino acid
E5554_RS01580	COG1496	oxidoreductase activity
E5554_RS01585	COG2186	Transcriptional regulator
E5554_RS01620	COG0438	transferase activity, transferring glycosyl groups
E5554_RS01640	COG2205	protein histidine kinase activity
E5554_RS01665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5554_RS01675	COG0671	phosphoesterase, PA-phosphatase related
E5554_RS01710	COG0438	transferase activity, transferring glycosyl groups
E5554_RS01725	COG0438	transferase activity, transferring glycosyl groups
E5554_RS01745	COG1538	Outer membrane efflux protein
E5554_RS01760	COG4774	siderophore transport
E5554_RS01775	COG3128	pkhd-type hydroxylase
E5554_RS01790	COG4774	siderophore transport
E5554_RS01835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5554_RS01880	COG0433	COG0433 Predicted ATPase
E5554_RS01905	COG4957	zinc ion binding
E5554_RS01910	COG0582	viral genome integration into host DNA
E5554_RS01915	COG4372	Transposase
E5554_RS01920	COG3436	PFAM IS66 Orf2 family protein
E5554_RS01960	COG0667	Aldo Keto reductase
E5554_RS01965	COG0175	sulfate reduction
E5554_RS01975	COG1218	3'(2'),5'-bisphosphate nucleotidase
E5554_RS01980	COG2272	Belongs to the type-B carboxylesterase lipase family
E5554_RS02010	COG2175	clavaminate synthase activity
E5554_RS02015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5554_RS02055	COG1960	acyl-CoA dehydrogenase activity
E5554_RS02060	COG1024	Enoyl-CoA hydratase
E5554_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS02110	COG0318	PFAM AMP-dependent synthetase and ligase
E5554_RS02115	COG0604	alcohol dehydrogenase
E5554_RS02145	COG0457	Tetratricopeptide repeat
E5554_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS02160	COG1063	alcohol dehydrogenase
E5554_RS02170	COG0175	sulfate reduction
E5554_RS02180	COG1218	3'(2'),5'-bisphosphate nucleotidase
E5554_RS02195	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS02210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5554_RS02235	COG4638	Rieske (2fe-2S)
E5554_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS02265	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5554_RS02275	COG1960	acyl-CoA dehydrogenase activity
E5554_RS02300	COG0183	Belongs to the thiolase family
E5554_RS02310	COG0366	Alpha amylase catalytic
E5554_RS02320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5554_RS02335	COG2205	protein histidine kinase activity
E5554_RS02360	COG4993	Dehydrogenase
E5554_RS02380	COG0427	acetyl-CoA hydrolase
E5554_RS02390	COG0318	PFAM AMP-dependent synthetase and ligase
E5554_RS02395	COG3474	cytochrome
E5554_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS02445	COG2124	cytochrome p450
E5554_RS02480	COG2244	polysaccharide biosynthetic process
E5554_RS02515	COG2890	protein-(glutamine-N5) methyltransferase activity
E5554_RS02520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5554_RS02525	COG0124	histidyl-tRNA synthetase
E5554_RS02535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5554_RS02545	COG2364	Membrane
E5554_RS02570	COG2818	Glycosylase
E5554_RS02585	COG1201	RNA secondary structure unwinding
E5554_RS02600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5554_RS02615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5554_RS02620	COG1127	ABC transporter
E5554_RS02635	COG0308	aminopeptidase N
E5554_RS02650	COG0357	Ribosomal RNA small subunit methyltransferase G
E5554_RS02655	COG0445	tRNA wobble uridine modification
E5554_RS02660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5554_RS02685	COG0861	Integral membrane protein TerC family
E5554_RS02690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5554_RS02700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5554_RS02705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5554_RS02720	COG0495	leucyl-tRNA aminoacylation
E5554_RS02750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5554_RS02780	COG2983	Belongs to the UPF0260 family
E5554_RS02785	COG1999	signal sequence binding
E5554_RS02815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5554_RS02820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5554_RS02825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5554_RS02830	COG0237	dephospho-CoA kinase activity
E5554_RS02835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5554_RS02840	COG0424	maF-like protein
E5554_RS02845	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5554_RS02850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5554_RS02855	COG1981	membrane
E5554_RS02865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5554_RS02870	COG1192	Involved in chromosome partitioning
E5554_RS02890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5554_RS02910	COG1674	ftsk spoiiie
E5554_RS02935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5554_RS02940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5554_RS02945	COG0281	malic enzyme
E5554_RS02945	COG0280	phosphate acetyltransferase
E5554_RS02970	COG1609	Transcriptional regulator
E5554_RS02975	COG1904	glucuronate isomerase
E5554_RS02980	COG2721	sulfolactate sulfo-lyase activity
E5554_RS02985	COG0776	regulation of translation
E5554_RS03000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5554_RS03060	COG1482	cell wall glycoprotein biosynthetic process
E5554_RS03190	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E5554_RS03240	COG5489	Protein of unknown function (DUF736)
E5554_RS03335	COG1506	peptidase
E5554_RS03335	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS03360	COG3547	Transposase (IS116 IS110 IS902 family)
E5554_RS03365	COG0640	Transcriptional regulator
E5554_RS03370	COG0450	alkyl hydroperoxide reductase
E5554_RS03405	COG1271	oxidase subunit
E5554_RS03410	COG1294	oxidase, subunit
E5554_RS03440	COG0798	PFAM Bile acid sodium symporter
E5554_RS03460	COG4962	Type ii secretion system protein e
E5554_RS03465	COG3838	Conjugal transfer protein Trbc
E5554_RS03475	COG3451	type IV secretory pathway VirB4
E5554_RS03485	COG3846	protein secretion by the type IV secretion system
E5554_RS03500	COG2948	multi-organism process
E5554_RS03520	COG3547	Transposase (IS116 IS110 IS902 family)
E5554_RS03570	COG0745	RESPONSE REGULATOR receiver
E5554_RS03575	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E5554_RS03585	COG0784	Response regulator, receiver
E5554_RS03585	COG2205	protein histidine kinase activity
E5554_RS03585	COG2198	Histidine kinase
E5554_RS03590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5554_RS03600	COG2205	protein histidine kinase activity
E5554_RS03605	COG0582	viral genome integration into host DNA
E5554_RS03635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5554_RS03650	COG2255	four-way junction helicase activity
E5554_RS03655	COG0632	four-way junction helicase activity
E5554_RS03685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5554_RS03690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5554_RS03695	COG0436	Aminotransferase
E5554_RS03720	COG1194	a g-specific adenine glycosylase
E5554_RS03725	COG2816	NAD+ diphosphatase activity
E5554_RS03730	COG0312	modulator of DNA gyrase
E5554_RS03735	COG0483	inositol monophosphate 1-phosphatase activity
E5554_RS03750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5554_RS03750	COG3743	rRNA binding
E5554_RS03755	COG0151	Belongs to the GarS family
E5554_RS03760	COG1570	exodeoxyribonuclease VII activity
E5554_RS03795	COG0457	Tetratricopeptide repeat
E5554_RS03815	COG0542	response to heat
E5554_RS03825	COG0612	Peptidase, M16
E5554_RS03840	COG1289	transmembrane transporter activity
E5554_RS03850	COG1566	PFAM secretion protein HlyD family protein
E5554_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS03880	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E5554_RS03890	COG1139	Iron-sulfur cluster binding protein
E5554_RS03895	COG0247	lactate metabolic process
E5554_RS03900	COG2755	lipolytic protein G-D-S-L family
E5554_RS03900	COG0657	acetylesterase activity
E5554_RS03905	COG2755	lipolytic protein G-D-S-L family
E5554_RS03915	COG1414	Transcriptional regulator
E5554_RS03920	COG4948	Mandelate Racemase Muconate Lactonizing
E5554_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS03985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
E5554_RS03995	COG3254	rhamnose metabolic process
E5554_RS04005	COG2755	lipolytic protein G-D-S-L family
E5554_RS04015	COG1414	Transcriptional regulator
E5554_RS04020	COG2885	chlorophyll binding
E5554_RS04025	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS04045	COG0824	Thioesterase
E5554_RS04050	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5554_RS04055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E5554_RS04060	COG1842	Phage shock protein A
E5554_RS04105	COG0405	Gamma-glutamyltransferase
E5554_RS04110	COG0167	dihydroorotate dehydrogenase activity
E5554_RS04125	COG0719	Fe-S assembly protein
E5554_RS04135	COG0396	ATPase activity
E5554_RS04140	COG0719	Fe-S assembly protein
E5554_RS04145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5554_RS04150	COG2151	metal-sulfur cluster biosynthetic enzyme
E5554_RS04155	COG0316	Belongs to the HesB IscA family
E5554_RS04175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5554_RS04180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5554_RS04185	COG3038	cytochrome b561
E5554_RS04190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5554_RS04205	COG0583	DNA-binding transcription factor activity
E5554_RS04210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5554_RS04225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5554_RS04230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E5554_RS04260	COG2308	Evidence 4 Homologs of previously reported genes of
E5554_RS04260	COG2307	Protein conserved in bacteria
E5554_RS04275	COG1505	serine-type exopeptidase activity
E5554_RS04285	COG1733	regulation of RNA biosynthetic process
E5554_RS04295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5554_RS04305	COG4115	mRNA cleavage
E5554_RS04350	COG1960	acyl-CoA dehydrogenase activity
E5554_RS04365	COG1960	acyl-CoA dehydrogenase activity
E5554_RS04370	COG1960	acyl-CoA dehydrogenase activity
E5554_RS04380	COG4638	Rieske (2fe-2S)
E5554_RS04400	COG0427	acetyl-CoA hydrolase
E5554_RS04405	COG1024	Enoyl-CoA hydratase
E5554_RS04410	COG4638	Rieske (2fe-2S)
E5554_RS04430	COG1024	Enoyl-CoA hydratase
E5554_RS04435	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E5554_RS04445	COG0318	PFAM AMP-dependent synthetase and ligase
E5554_RS04475	COG0183	Belongs to the thiolase family
E5554_RS04480	COG2814	Major facilitator Superfamily
E5554_RS04485	COG4771	TonB-dependent receptor
E5554_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS04505	COG0300	oxidoreductase activity
E5554_RS04530	COG2814	Major facilitator Superfamily
E5554_RS04570	COG0604	alcohol dehydrogenase
E5554_RS04570	COG3321	synthase
E5554_RS04575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5554_RS04580	COG0022	dehydrogenase e1 component
E5554_RS04585	COG1522	sequence-specific DNA binding
E5554_RS04590	COG3186	Phenylalanine-4-hydroxylase
E5554_RS04595	COG1448	Aminotransferase
E5554_RS04605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E5554_RS04615	COG0625	glutathione transferase activity
E5554_RS04640	COG0778	Nitroreductase
E5554_RS04645	COG5265	(ABC) transporter
E5554_RS04665	COG2850	peptidyl-arginine hydroxylation
E5554_RS04670	COG0746	molybdenum cofactor guanylyltransferase activity
E5554_RS04675	COG0475	glutathione-regulated potassium exporter activity
E5554_RS04705	COG0673	inositol 2-dehydrogenase activity
E5554_RS04750	COG1609	Transcriptional regulator
E5554_RS04765	COG1940	carbohydrate kinase activity
E5554_RS04785	COG4974	Belongs to the 'phage' integrase family
E5554_RS04810	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E5554_RS04815	COG1285	pathogenesis
E5554_RS04845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5554_RS04850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5554_RS04850	COG2010	Cytochrome c
E5554_RS04870	COG0784	Response regulator, receiver
E5554_RS04870	COG4191	Histidine kinase
E5554_RS04890	COG0427	acetyl-CoA hydrolase
E5554_RS04895	COG2116	formate transmembrane transporter activity
E5554_RS04955	COG0753	catalase activity
E5554_RS04965	COG0784	Response regulator, receiver
E5554_RS04965	COG4191	Histidine kinase
E5554_RS04985	COG0366	Alpha amylase catalytic
E5554_RS04995	COG0693	protein deglycase activity
E5554_RS05015	COG0297	glycogen (starch) synthase activity
E5554_RS05025	COG0628	permease
E5554_RS05035	COG4297	protein containing double-stranded beta helix domain
E5554_RS05055	COG0069	glutamate synthase activity
E5554_RS05060	COG0028	Belongs to the TPP enzyme family
E5554_RS05070	COG1695	Transcriptional regulator
E5554_RS05090	COG4529	Protein conserved in bacteria
E5554_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS05120	COG0741	lytic transglycosylase activity
E5554_RS05165	COG5489	Protein of unknown function (DUF736)
E5554_RS05205	COG2771	luxR family
E5554_RS05270	COG0302	gtp cyclohydrolase
E5554_RS05275	COG4566	intracellular signal transduction
E5554_RS05315	COG2197	response regulator
E5554_RS05335	COG0459	protein refolding
E5554_RS05340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5554_RS05350	COG5425	PFAM Usg family protein
E5554_RS05365	COG0071	Belongs to the small heat shock protein (HSP20) family
E5554_RS05370	COG0071	Belongs to the small heat shock protein (HSP20) family
E5554_RS05390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5554_RS05395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5554_RS05400	COG2080	2 iron, 2 sulfur cluster binding
E5554_RS05415	COG0587	DNA-directed DNA polymerase activity
E5554_RS05445	COG4962	Type ii secretion system protein e
E5554_RS05460	COG3451	type IV secretory pathway VirB4
E5554_RS05535	COG1278	Cold shock
E5554_RS05595	COG0006	proline dipeptidase activity
E5554_RS05615	COG4206	TonB-dependent receptor
E5554_RS05625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5554_RS05635	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5554_RS05655	COG2171	N-acyltransferase activity
E5554_RS05665	COG1611	Belongs to the LOG family
E5554_RS05675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5554_RS05680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5554_RS05685	COG2852	Protein conserved in bacteria
E5554_RS05690	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5554_RS05700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5554_RS05720	COG1301	dicarboxylic acid transport
E5554_RS05725	COG3781	membrane
E5554_RS05730	COG1301	dicarboxylic acid transport
E5554_RS05735	COG0259	pyridoxamine-phosphate oxidase activity
E5554_RS05740	COG0484	heat shock protein binding
E5554_RS05745	COG1295	ribonuclease BN
E5554_RS05750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5554_RS05755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5554_RS05760	COG0471	metal ion transport
E5554_RS05760	COG3273	potassium ion transport
E5554_RS05780	COG0514	ATP-dependent DNA helicase (RecQ)
E5554_RS05790	COG1230	cation diffusion facilitator family transporter
E5554_RS05825	COG0004	ammonium transporteR
E5554_RS05830	COG0347	Belongs to the P(II) protein family
E5554_RS05840	COG0312	modulator of DNA gyrase
E5554_RS05870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5554_RS05875	COG1137	ATPase activity
E5554_RS05890	COG2211	Major facilitator Superfamily
E5554_RS05895	COG4771	TonB-dependent receptor
E5554_RS05905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5554_RS05910	COG0243	molybdopterin cofactor binding
E5554_RS05940	COG1968	undecaprenyl-diphosphatase activity
E5554_RS05945	COG1091	dTDP-4-dehydrorhamnose reductase activity
E5554_RS05950	COG2119	membrane
E5554_RS05970	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E5554_RS05980	COG0793	Belongs to the peptidase S41A family
E5554_RS05995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5554_RS06000	COG0799	negative regulation of ribosome biogenesis
E5554_RS06005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5554_RS06010	COG2755	lipolytic protein G-D-S-L family
E5554_RS06010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5554_RS06015	COG1322	Protein conserved in bacteria
E5554_RS06030	COG0300	oxidoreductase activity
E5554_RS06050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5554_RS06060	COG3706	GGDEF domain
E5554_RS06065	COG0519	Catalyzes the synthesis of GMP from XMP
E5554_RS06065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5554_RS06075	COG0412	Dienelactone hydrolase
E5554_RS06080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5554_RS06095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5554_RS06130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5554_RS06135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5554_RS06160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5554_RS06175	COG5001	Diguanylate cyclase
E5554_RS06175	COG3300	MHYT domain
E5554_RS06185	COG2234	aminopeptidase activity
E5554_RS06235	COG3093	addiction module antidote protein HigA
E5554_RS06245	COG0556	nucleotide-excision repair
E5554_RS06315	COG4771	TonB-dependent receptor
E5554_RS06320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5554_RS06320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5554_RS06330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5554_RS06330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5554_RS06380	COG1393	Belongs to the ArsC family
E5554_RS06385	COG0584	glycerophosphoryl diester phosphodiesterase
E5554_RS06390	COG1959	2 iron, 2 sulfur cluster binding
E5554_RS06400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5554_RS06410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5554_RS06415	COG0416	fatty acid biosynthetic process
E5554_RS06420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5554_RS06425	COG0776	regulation of translation
E5554_RS06445	COG1199	ATP-dependent helicase activity
E5554_RS06445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5554_RS06455	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E5554_RS06480	COG4251	negative regulation of phosphorylation
E5554_RS06500	COG0436	Aminotransferase
E5554_RS06505	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5554_RS06515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5554_RS06530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5554_RS06535	COG0753	catalase activity
E5554_RS06550	COG1494	fructose-1,6-bisphosphatase
E5554_RS06595	COG1132	(ABC) transporter
E5554_RS06605	COG4948	Mandelate Racemase Muconate Lactonizing
E5554_RS06655	COG2932	Transcriptional regulator
E5554_RS06660	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5554_RS06665	COG2879	small protein
E5554_RS06670	COG1966	Carbon starvation protein
E5554_RS06695	COG2824	Alkylphosphonate utilization operon protein PhnA
E5554_RS06700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5554_RS06705	COG0706	membrane insertase activity
E5554_RS06710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5554_RS06715	COG0594	ribonuclease P activity
E5554_RS06720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5554_RS06735	COG1530	ribonuclease E activity
E5554_RS06740	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5554_RS06745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E5554_RS06790	COG0626	cystathionine gamma-synthase activity
E5554_RS06795	COG2897	thiosulfate sulfurtransferase activity
E5554_RS06805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5554_RS06835	COG1297	OPT oligopeptide transporter protein
E5554_RS06870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5554_RS06885	COG2267	carboxylic ester hydrolase activity
E5554_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS06940	COG2814	Major facilitator Superfamily
E5554_RS06945	COG3135	benzoate transporter
E5554_RS06970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5554_RS06995	COG2205	protein histidine kinase activity
E5554_RS07015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5554_RS07035	COG3609	addiction module antidote protein, CC2985 family
E5554_RS07040	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E5554_RS07045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5554_RS07065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5554_RS07080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5554_RS07100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5554_RS07105	COG0217	transcriptional regulatory protein
E5554_RS07125	COG0469	pyruvate kinase activity
E5554_RS07130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5554_RS07140	COG2866	Carboxypeptidase
E5554_RS07155	COG2264	protein methyltransferase activity
E5554_RS07175	COG1053	succinate dehydrogenase
E5554_RS07195	COG0443	Heat shock 70 kDa protein
E5554_RS07200	COG0484	heat shock protein binding
E5554_RS07205	COG0531	amino acid
E5554_RS07215	COG1960	acyl-CoA dehydrogenase activity
E5554_RS07225	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E5554_RS07235	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5554_RS07250	COG0438	transferase activity, transferring glycosyl groups
E5554_RS07250	COG0297	glycogen (starch) synthase activity
E5554_RS07260	COG1024	Enoyl-CoA hydratase
E5554_RS07265	COG2207	Transcriptional regulator
E5554_RS07270	COG4638	Rieske (2fe-2S)
E5554_RS07300	COG1053	succinate dehydrogenase
E5554_RS07315	COG2226	methyltransferase
E5554_RS07320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5554_RS07325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5554_RS07340	COG4638	Rieske (2fe-2S)
E5554_RS07355	COG2124	cytochrome p450
E5554_RS07360	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS07370	COG4771	TonB-dependent receptor
E5554_RS07375	COG2365	Tyrosine phosphatase family
E5554_RS07380	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS07385	COG1482	cell wall glycoprotein biosynthetic process
E5554_RS07465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5554_RS07475	COG2076	Multidrug Resistance protein
E5554_RS07485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E5554_RS07495	COG4773	Receptor
E5554_RS07500	COG2885	chlorophyll binding
E5554_RS07505	COG0488	(ABC) transporter
E5554_RS07510	COG0628	permease
E5554_RS07560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5554_RS07575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5554_RS07580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5554_RS07595	COG1476	TRANSCRIPTIONal
E5554_RS07615	COG0756	dUTP diphosphatase activity
E5554_RS07620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5554_RS07625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5554_RS07630	COG2226	methyltransferase
E5554_RS07635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5554_RS07640	COG0268	Binds directly to 16S ribosomal RNA
E5554_RS07645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5554_RS07675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5554_RS07680	COG0728	peptidoglycan biosynthetic process
E5554_RS07685	COG0180	Tryptophanyl-tRNA synthetase
E5554_RS07695	COG1301	dicarboxylic acid transport
E5554_RS07700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5554_RS07710	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5554_RS07720	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5554_RS07745	COG0318	PFAM AMP-dependent synthetase and ligase
E5554_RS07750	COG5001	Diguanylate cyclase
E5554_RS07755	COG1192	Involved in chromosome partitioning
E5554_RS07765	COG0439	Biotin carboxylase
E5554_RS07770	COG0511	ligase activity, forming carbon-carbon bonds
E5554_RS07780	COG2022	thiamine diphosphate biosynthetic process
E5554_RS07810	COG0537	adenosine 5'-monophosphoramidase activity
E5554_RS07830	COG4149	molybdate abc transporter
E5554_RS07835	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5554_RS07840	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5554_RS07845	COG0243	molybdopterin cofactor binding
E5554_RS07855	COG0438	transferase activity, transferring glycosyl groups
E5554_RS07900	COG0784	Response regulator, receiver
E5554_RS07900	COG2198	Histidine kinase
E5554_RS07900	COG0643	Histidine kinase
E5554_RS07910	COG0745	RESPONSE REGULATOR receiver
E5554_RS07915	COG2201	protein-glutamate methylesterase activity
E5554_RS07920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5554_RS07925	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5554_RS07955	COG0840	transmembrane signaling receptor activity
E5554_RS07970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5554_RS07980	COG2917	probably involved in intracellular septation
E5554_RS07985	COG0552	protein localization to endoplasmic reticulum
E5554_RS07990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5554_RS07995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5554_RS08005	COG4206	TonB-dependent receptor
E5554_RS08010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5554_RS08015	COG1120	ATPase activity
E5554_RS08025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5554_RS08030	COG0792	nuclease activity
E5554_RS08035	COG0189	ligase activity
E5554_RS08040	COG0586	Pfam SNARE associated Golgi protein
E5554_RS08065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5554_RS08070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5554_RS08075	COG1505	serine-type exopeptidase activity
E5554_RS08100	COG4166	transmembrane transport
E5554_RS08115	COG0222	ribosome binding
E5554_RS08120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5554_RS08125	COG3657	addiction module killer protein
E5554_RS08130	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5554_RS08145	COG3275	phosphorelay sensor kinase activity
E5554_RS08150	COG3279	Response regulator of the LytR AlgR family
E5554_RS08155	COG4221	oxidoreductase activity
E5554_RS08160	COG2207	Transcriptional regulator
E5554_RS08175	COG0590	tRNA wobble adenosine to inosine editing
E5554_RS08185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5554_RS08220	COG0646	methionine synthase
E5554_RS08220	COG1410	methionine synthase
E5554_RS08260	COG2853	Lipoprotein
E5554_RS08280	COG0582	viral genome integration into host DNA
E5554_RS08310	COG4251	negative regulation of phosphorylation
E5554_RS08335	COG0745	RESPONSE REGULATOR receiver
E5554_RS08340	COG5002	protein histidine kinase activity
E5554_RS08460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5554_RS08490	COG0693	protein deglycase activity
E5554_RS08500	COG0784	Response regulator, receiver
E5554_RS08500	COG4191	Histidine kinase
E5554_RS08535	COG3920	Histidine kinase
E5554_RS08535	COG2202	Pas domain
E5554_RS08565	COG1309	transcriptional regulator
E5554_RS08575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5554_RS08580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5554_RS08590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E5554_RS08595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5554_RS08605	COG0105	UTP biosynthetic process
E5554_RS08640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5554_RS08655	COG1506	peptidase
E5554_RS08655	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS08670	COG0525	valine-tRNA ligase activity
E5554_RS08675	COG0534	Mate efflux family protein
E5554_RS08690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5554_RS08705	COG1160	GTP binding
E5554_RS08720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5554_RS08725	COG4771	TonB-dependent receptor
E5554_RS08745	COG1764	response to oxidative stress
E5554_RS08750	COG0697	spore germination
E5554_RS08770	COG0438	transferase activity, transferring glycosyl groups
E5554_RS08790	COG0463	Glycosyl transferase, family 2
E5554_RS08805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5554_RS08810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5554_RS08815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5554_RS08825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5554_RS08830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5554_RS08840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5554_RS08840	COG2169	Transcriptional regulator
E5554_RS08850	COG2199	diguanylate cyclase activity
E5554_RS08855	COG2885	chlorophyll binding
E5554_RS08875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5554_RS08885	COG3706	GGDEF domain
E5554_RS08905	COG3447	MASE1 domain protein
E5554_RS08905	COG5002	protein histidine kinase activity
E5554_RS08905	COG3447	MASE1 domain protein
E5554_RS08905	COG5001	Diguanylate cyclase
E5554_RS08905	COG5002	protein histidine kinase activity
E5554_RS08905	COG5001	Diguanylate cyclase
E5554_RS08910	COG0101	tRNA pseudouridine synthase activity
E5554_RS08915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5554_RS08920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5554_RS08950	COG1278	Cold shock
E5554_RS08970	COG1396	sequence-specific DNA binding
E5554_RS08970	COG3800	Transcriptional regulator
E5554_RS08975	COG0306	phosphate transporter
E5554_RS08980	COG1392	Phosphate transport regulator
E5554_RS08985	COG4771	TonB-dependent receptor
E5554_RS08990	COG0583	DNA-binding transcription factor activity
E5554_RS09045	COG0137	argininosuccinate synthase activity
E5554_RS09060	COG2205	protein histidine kinase activity
E5554_RS09095	COG1706	bacterial-type flagellum-dependent cell motility
E5554_RS09100	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5554_RS09110	COG4787	bacterial-type flagellum-dependent cell motility
E5554_RS09115	COG4786	Flagellar basal body rod
E5554_RS09120	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E5554_RS09125	COG1558	bacterial-type flagellum-dependent cell motility
E5554_RS09135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5554_RS09180	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E5554_RS09195	COG1677	Flagellar hook-basal body complex protein FliE
E5554_RS09205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5554_RS09255	COG1987	bacterial-type flagellum assembly
E5554_RS09285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5554_RS09290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5554_RS09305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5554_RS09310	COG0602	queuosine metabolic process
E5554_RS09325	COG0321	lipoyl(octanoyl) transferase activity
E5554_RS09340	COG0408	coproporphyrinogen oxidase activity
E5554_RS09345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5554_RS09365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5554_RS09385	COG1301	dicarboxylic acid transport
E5554_RS09400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5554_RS09400	COG2755	lipolytic protein G-D-S-L family
E5554_RS09410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E5554_RS09420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5554_RS09430	COG0215	cysteine-tRNA ligase activity
E5554_RS09435	COG0789	Transcriptional regulator
E5554_RS09440	COG0670	Belongs to the BI1 family
E5554_RS09455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5554_RS09455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5554_RS09475	COG2267	carboxylic ester hydrolase activity
E5554_RS09485	COG1131	(ABC) transporter
E5554_RS09505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5554_RS09515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5554_RS09520	COG0165	Argininosuccinate lyase
E5554_RS09530	COG0019	diaminopimelate decarboxylase activity
E5554_RS09535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5554_RS09535	COG1648	precorrin-2 dehydrogenase activity
E5554_RS09550	COG1538	Outer membrane efflux protein
E5554_RS09560	COG2814	Major facilitator Superfamily
E5554_RS09565	COG0531	amino acid
E5554_RS09575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5554_RS09580	COG0228	four-way junction DNA binding
E5554_RS09585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5554_RS09610	COG0336	Belongs to the RNA methyltransferase TrmD family
E5554_RS09615	COG0335	large ribosomal subunit rRNA binding
E5554_RS09630	COG0477	Major facilitator Superfamily
E5554_RS09635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5554_RS09640	COG3706	GGDEF domain
E5554_RS09645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5554_RS09650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5554_RS09650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5554_RS09655	COG1660	Displays ATPase and GTPase activities
E5554_RS09660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5554_RS09665	COG2205	protein histidine kinase activity
E5554_RS09670	COG0745	RESPONSE REGULATOR receiver
E5554_RS09675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E5554_RS09720	COG0330	HflC and HflK could
E5554_RS09725	COG2301	Belongs to the HpcH HpaI aldolase family
E5554_RS09735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5554_RS09750	COG3794	PFAM blue (type 1) copper domain protein
E5554_RS09755	COG0577	efflux transmembrane transporter activity
E5554_RS09755	COG1136	(ABC) transporter
E5554_RS09760	COG0577	efflux transmembrane transporter activity
E5554_RS09760	COG1136	(ABC) transporter
E5554_RS09765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5554_RS09780	COG4191	Histidine kinase
E5554_RS09785	COG0667	Aldo Keto reductase
E5554_RS09790	COG0586	Pfam SNARE associated Golgi protein
E5554_RS09795	COG0861	Integral membrane protein TerC family
E5554_RS09805	COG2851	Citrate transporter
E5554_RS09820	COG0745	RESPONSE REGULATOR receiver
E5554_RS09825	COG0642	Histidine kinase
E5554_RS09830	COG0457	Tetratricopeptide repeat
E5554_RS09855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5554_RS09865	COG2070	2-Nitropropane dioxygenase
E5554_RS09880	COG1733	regulation of RNA biosynthetic process
E5554_RS09905	COG5507	3-demethylubiquinone-9 3-methyltransferase
E5554_RS09960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5554_RS09965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5554_RS09985	COG0037	tRNA processing
E5554_RS10000	COG4716	Myosin-crossreactive antigen
E5554_RS10010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5554_RS10060	COG1794	racemase activity, acting on amino acids and derivatives
E5554_RS10065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5554_RS10070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E5554_RS10105	COG4964	Belongs to the GSP D family
E5554_RS10130	COG3422	double-strand break repair
E5554_RS10135	COG0328	RNA-DNA hybrid ribonuclease activity
E5554_RS10140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5554_RS10145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5554_RS10155	COG0018	arginyl-trna synthetase
E5554_RS10170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5554_RS10175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5554_RS10180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5554_RS10185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5554_RS10190	COG0805	protein transport
E5554_RS10200	COG3409	Peptidoglycan-binding domain 1 protein
E5554_RS10200	COG3773	Cell wall hydrolase
E5554_RS10205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5554_RS10225	COG0275	rRNA processing
E5554_RS10240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5554_RS10250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5554_RS10255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5554_RS10265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5554_RS10270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5554_RS10280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5554_RS10285	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5554_RS10290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5554_RS10295	COG0849	cell division
E5554_RS10300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5554_RS10310	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E5554_RS10350	COG3537	Alpha-1,2-mannosidase
E5554_RS10355	COG0505	Belongs to the CarA family
E5554_RS10360	COG3386	PFAM SMP-30 Gluconolaconase
E5554_RS10365	COG0673	inositol 2-dehydrogenase activity
E5554_RS10380	COG2186	Transcriptional regulator
E5554_RS10390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5554_RS10395	COG0509	glycine decarboxylation via glycine cleavage system
E5554_RS10400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5554_RS10405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5554_RS10430	COG0156	8-amino-7-oxononanoate synthase activity
E5554_RS10445	COG1643	Atp-dependent helicase
E5554_RS10450	COG3119	arylsulfatase activity
E5554_RS10460	COG0142	geranyltranstransferase activity
E5554_RS10465	COG0287	Prephenate dehydrogenase
E5554_RS10465	COG1605	Chorismate mutase
E5554_RS10480	COG2610	gluconate transmembrane transporter activity
E5554_RS10490	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5554_RS10495	COG4133	protoheme IX ABC transporter activity
E5554_RS10505	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5554_RS10530	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5554_RS10530	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5554_RS10540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5554_RS10545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5554_RS10550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5554_RS10570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5554_RS10575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5554_RS10585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5554_RS10585	COG4651	solute:proton antiporter activity
E5554_RS10595	COG0081	regulation of translation
E5554_RS10600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5554_RS10605	COG0250	Participates in transcription elongation, termination and antitermination
E5554_RS10625	COG3706	GGDEF domain
E5554_RS10630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5554_RS10635	COG0540	Belongs to the ATCase OTCase family
E5554_RS10660	COG1024	Enoyl-CoA hydratase
E5554_RS10685	COG1846	Transcriptional regulator
E5554_RS10715	COG2099	Precorrin-6x reductase
E5554_RS10730	COG2875	Belongs to the precorrin methyltransferase family
E5554_RS10735	COG1797	cobyrinic acid a,c-diamide synthase activity
E5554_RS10780	COG0477	Major facilitator Superfamily
E5554_RS10795	COG4771	TonB-dependent receptor
E5554_RS10805	COG0583	DNA-binding transcription factor activity
E5554_RS10810	COG0667	Aldo Keto reductase
E5554_RS10815	COG2814	Major facilitator Superfamily
E5554_RS10855	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E5554_RS10875	COG2197	response regulator
E5554_RS10880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5554_RS10885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5554_RS10890	COG2267	carboxylic ester hydrolase activity
E5554_RS10895	COG0251	oxidation-reduction process
E5554_RS10900	COG1335	isochorismatase
E5554_RS10905	COG2814	Major facilitator Superfamily
E5554_RS10910	COG0583	DNA-binding transcription factor activity
E5554_RS10915	COG0596	Alpha beta hydrolase
E5554_RS10935	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E5554_RS10945	COG3346	SURF1 family
E5554_RS10950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5554_RS10955	COG1845	cytochrome c oxidase, subunit III
E5554_RS10960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5554_RS10965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5554_RS10970	COG0477	Major facilitator Superfamily
E5554_RS10980	COG0004	ammonium transporteR
E5554_RS11085	COG2234	aminopeptidase activity
E5554_RS11095	COG0778	Nitroreductase
E5554_RS11110	COG4695	Portal protein
E5554_RS11205	COG2885	chlorophyll binding
E5554_RS11205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E5554_RS11210	COG2032	superoxide dismutase activity
E5554_RS11250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5554_RS11260	COG4191	Histidine kinase
E5554_RS11260	COG0784	Response regulator, receiver
E5554_RS11265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5554_RS11270	COG1309	transcriptional regulator
E5554_RS11275	COG1960	acyl-CoA dehydrogenase activity
E5554_RS11280	COG0589	response to stress
E5554_RS11285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E5554_RS11290	COG4988	ABC transporter
E5554_RS11300	COG1294	oxidase, subunit
E5554_RS11325	COG0730	response to heat
E5554_RS11335	COG2271	Major facilitator Superfamily
E5554_RS11345	COG1609	Transcriptional regulator
E5554_RS11350	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E5554_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS11360	COG2272	Belongs to the type-B carboxylesterase lipase family
E5554_RS11395	COG3507	Belongs to the glycosyl hydrolase 43 family
E5554_RS11400	COG0346	lactoylglutathione lyase activity
E5554_RS11405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E5554_RS11405	COG0392	lysyltransferase activity
E5554_RS11435	COG1215	transferase activity, transferring glycosyl groups
E5554_RS11440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5554_RS11460	COG0045	succinate-CoA ligase (ADP-forming) activity
E5554_RS11465	COG2086	electron transfer activity
E5554_RS11490	COG1278	Cold shock
E5554_RS11525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5554_RS11555	COG2972	Histidine kinase
E5554_RS11580	COG2945	thiolester hydrolase activity
E5554_RS11615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5554_RS11640	COG4771	TonB-dependent receptor
E5554_RS11645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5554_RS11670	COG2814	Major facilitator Superfamily
E5554_RS11685	COG0280	phosphate acetyltransferase
E5554_RS11685	COG0281	malic enzyme
E5554_RS11690	COG0583	DNA-binding transcription factor activity
E5554_RS11695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5554_RS11700	COG0625	glutathione transferase activity
E5554_RS11710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5554_RS11725	COG2066	Belongs to the glutaminase family
E5554_RS11745	COG0776	regulation of translation
E5554_RS11750	COG0539	negative regulation of cytoplasmic translation
E5554_RS11755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5554_RS11760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5554_RS11785	COG0210	DNA helicase
E5554_RS11810	COG0742	ribosomal rna small subunit methyltransferase
E5554_RS11815	COG1187	pseudouridine synthase activity
E5554_RS11825	COG2223	nitrite transmembrane transporter activity
E5554_RS11845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5554_RS11850	COG0159	tryptophan synthase activity
E5554_RS11855	COG0133	tryptophan synthase activity
E5554_RS11860	COG0135	phosphoribosylanthranilate isomerase activity
E5554_RS11880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5554_RS11895	COG1522	sequence-specific DNA binding
E5554_RS11900	COG2202	Pas domain
E5554_RS11900	COG2205	protein histidine kinase activity
E5554_RS11915	COG0582	viral genome integration into host DNA
E5554_RS11935	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS11945	COG3108	Peptidase M15
E5554_RS11950	COG1376	ErfK ybiS ycfS ynhG family protein
E5554_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS12000	COG1733	regulation of RNA biosynthetic process
E5554_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS12010	COG0326	Molecular chaperone. Has ATPase activity
E5554_RS12020	COG4957	zinc ion binding
E5554_RS12050	COG4372	Transposase
E5554_RS12055	COG3436	PFAM IS66 Orf2 family protein
E5554_RS12095	COG0297	glycogen (starch) synthase activity
E5554_RS12175	COG0583	DNA-binding transcription factor activity
E5554_RS12180	COG1902	pentaerythritol trinitrate reductase activity
E5554_RS12210	COG3781	membrane
E5554_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS12335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5554_RS12340	COG1621	beta-fructofuranosidase activity
E5554_RS12345	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5554_RS12350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5554_RS12355	COG1609	Transcriptional regulator
E5554_RS12360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5554_RS12360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5554_RS12365	COG1105	Belongs to the carbohydrate kinase PfkB family
E5554_RS12370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5554_RS12370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5554_RS12380	COG1940	carbohydrate kinase activity
E5554_RS12390	COG1940	carbohydrate kinase activity
E5554_RS12395	COG2814	Major facilitator Superfamily
E5554_RS12400	COG1621	beta-fructofuranosidase activity
E5554_RS12415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5554_RS12465	COG3300	MHYT domain
E5554_RS12465	COG5001	Diguanylate cyclase
E5554_RS12470	COG0667	Aldo Keto reductase
E5554_RS12480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5554_RS12500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5554_RS12505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5554_RS12530	COG0113	porphobilinogen synthase activity
E5554_RS12535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5554_RS12560	COG0800	Aldolase
E5554_RS12565	COG0837	glucose binding
E5554_RS12570	COG0129	dihydroxy-acid dehydratase activity
E5554_RS12575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5554_RS12595	COG0640	Transcriptional regulator
E5554_RS12610	COG0436	Aminotransferase
E5554_RS12620	COG0363	glucosamine-6-phosphate deaminase activity
E5554_RS12625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5554_RS12635	COG1024	Enoyl-CoA hydratase
E5554_RS12635	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5554_RS12640	COG0183	Belongs to the thiolase family
E5554_RS12650	COG2814	Major facilitator Superfamily
E5554_RS12685	COG2226	methyltransferase
E5554_RS12695	COG1131	(ABC) transporter
E5554_RS12700	COG0842	Transport permease protein
E5554_RS12710	COG0534	Mate efflux family protein
E5554_RS12715	COG2354	Protein conserved in bacteria
E5554_RS12740	COG0359	binds to the 23S rRNA
E5554_RS12745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5554_RS12750	COG0360	Binds together with S18 to 16S ribosomal RNA
E5554_RS12755	COG2610	gluconate transmembrane transporter activity
E5554_RS12775	COG0577	efflux transmembrane transporter activity
E5554_RS12775	COG1136	(ABC) transporter
E5554_RS12780	COG1136	(ABC) transporter
E5554_RS12780	COG0577	efflux transmembrane transporter activity
E5554_RS12795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5554_RS12800	COG1024	Enoyl-CoA hydratase
E5554_RS12815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5554_RS12820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5554_RS12825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5554_RS12830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5554_RS12865	COG4774	siderophore transport
E5554_RS12875	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS12910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5554_RS12935	COG1252	NADH dehydrogenase
E5554_RS12945	COG2308	Evidence 4 Homologs of previously reported genes of
E5554_RS12955	COG1305	Transglutaminase-like
E5554_RS12965	COG2267	carboxylic ester hydrolase activity
E5554_RS12970	COG0492	ferredoxin-NADP+ reductase activity
E5554_RS12975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5554_RS12985	COG0318	PFAM AMP-dependent synthetase and ligase
E5554_RS13005	COG0489	protein tyrosine kinase activity
E5554_RS13015	COG3409	Peptidoglycan-binding domain 1 protein
E5554_RS13015	COG3267	Type II secretory pathway component ExeA
E5554_RS13045	COG0367	asparagine synthase
E5554_RS13050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5554_RS13090	COG2084	Dehydrogenase
E5554_RS13095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5554_RS13100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E5554_RS13105	COG5001	Diguanylate cyclase
E5554_RS13105	COG4251	negative regulation of phosphorylation
E5554_RS13105	COG3706	GGDEF domain
E5554_RS13105	COG2203	Gaf domain
E5554_RS13120	COG1956	GAF domain-containing protein
E5554_RS13135	COG0564	pseudouridine synthase activity
E5554_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS13165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5554_RS13180	COG1741	Belongs to the pirin family
E5554_RS13210	COG1595	DNA-templated transcription, initiation
E5554_RS13220	COG4771	TonB-dependent receptor
E5554_RS13225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5554_RS13230	COG0717	Belongs to the dCTP deaminase family
E5554_RS13235	COG0295	cytidine deaminase activity
E5554_RS13240	COG3757	hydrolase, family 25
E5554_RS13245	COG5328	Belongs to the UPF0262 family
E5554_RS13250	COG0305	Participates in initiation and elongation during chromosome replication
E5554_RS13270	COG0175	sulfate reduction
E5554_RS13290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5554_RS13290	COG1648	precorrin-2 dehydrogenase activity
E5554_RS13295	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS13325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5554_RS13350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5554_RS13360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5554_RS13410	COG1506	peptidase
E5554_RS13410	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS13420	COG0583	DNA-binding transcription factor activity
E5554_RS13425	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5554_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS13460	COG0025	NhaP-type Na H and K H
E5554_RS13465	COG0306	phosphate transporter
E5554_RS13485	COG1063	alcohol dehydrogenase
E5554_RS13490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5554_RS13495	COG1024	Enoyl-CoA hydratase
E5554_RS13520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5554_RS13525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5554_RS13535	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5554_RS13560	COG1024	Enoyl-CoA hydratase
E5554_RS13560	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5554_RS13575	COG2814	Major facilitator Superfamily
E5554_RS13580	COG1960	acyl-CoA dehydrogenase activity
E5554_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS13615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5554_RS13625	COG0183	Belongs to the thiolase family
E5554_RS13635	COG1024	Enoyl-CoA hydratase
E5554_RS13645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5554_RS13650	COG3474	cytochrome
E5554_RS13660	COG0183	Belongs to the thiolase family
E5554_RS13665	COG1960	acyl-CoA dehydrogenase activity
E5554_RS13670	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E5554_RS13675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5554_RS13680	COG2130	NADP-dependent
E5554_RS13690	COG1960	acyl-CoA dehydrogenase activity
E5554_RS13695	COG2124	cytochrome p450
E5554_RS13710	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS13740	COG0772	Belongs to the SEDS family
E5554_RS13765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5554_RS13770	COG0616	signal peptide processing
E5554_RS13775	COG0588	phosphoglycerate mutase activity
E5554_RS13785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5554_RS13795	COG0196	riboflavin kinase activity
E5554_RS13800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5554_RS13805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5554_RS13830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5554_RS13835	COG3172	ATPase kinase involved in NAD metabolism
E5554_RS13870	COG0667	Aldo Keto reductase
E5554_RS13875	COG1671	Belongs to the UPF0178 family
E5554_RS13880	COG2081	HI0933 family
E5554_RS13885	COG0784	Response regulator, receiver
E5554_RS13885	COG4191	Histidine kinase
E5554_RS13905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5554_RS13915	COG0314	molybdopterin synthase activity
E5554_RS13920	COG0583	DNA-binding transcription factor activity
E5554_RS13925	COG0730	response to heat
E5554_RS13930	COG1045	serine acetyltransferase
E5554_RS13940	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5554_RS13970	COG1216	Glycosyl transferase, family 2
E5554_RS13975	COG0463	Glycosyl transferase, family 2
E5554_RS13995	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E5554_RS14050	COG1858	cytochrome C peroxidase
E5554_RS14065	COG0598	Magnesium transport protein CorA
E5554_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS14085	COG4221	oxidoreductase activity
E5554_RS14115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5554_RS14120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5554_RS14125	COG2188	Transcriptional regulator
E5554_RS14135	COG3525	Glycosyl hydrolase, family 20, catalytic domain
E5554_RS14140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5554_RS14140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5554_RS14145	COG1263	PTS System
E5554_RS14145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5554_RS14150	COG0488	(ABC) transporter
E5554_RS14175	COG0457	Tetratricopeptide repeat
E5554_RS14190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5554_RS14200	COG2986	histidine ammonia-lyase
E5554_RS14205	COG1228	amidohydrolase
E5554_RS14215	COG2188	Transcriptional regulator
E5554_RS14220	COG1228	amidohydrolase
E5554_RS14230	COG1228	amidohydrolase
E5554_RS14245	COG3104	oligopeptide transport
E5554_RS14275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5554_RS14280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5554_RS14285	COG3938	Belongs to the proline racemase family
E5554_RS14295	COG0531	amino acid
E5554_RS14305	COG4206	TonB-dependent receptor
E5554_RS14310	COG0405	Gamma-glutamyltransferase
E5554_RS14315	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS14320	COG3707	response regulator
E5554_RS14325	COG1116	anion transmembrane transporter activity
E5554_RS14325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5554_RS14330	COG2223	nitrite transmembrane transporter activity
E5554_RS14340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5554_RS14350	COG0243	molybdopterin cofactor binding
E5554_RS14355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5554_RS14355	COG1648	precorrin-2 dehydrogenase activity
E5554_RS14375	COG0488	(ABC) transporter
E5554_RS14380	COG1858	cytochrome C peroxidase
E5554_RS14390	COG1254	Belongs to the acylphosphatase family
E5554_RS14405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5554_RS14410	COG2867	negative regulation of translational initiation
E5554_RS14415	COG1546	Belongs to the CinA family
E5554_RS14420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5554_RS14420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5554_RS14440	COG5000	phosphorelay sensor kinase activity
E5554_RS14445	COG2204	response regulator
E5554_RS14450	COG1923	regulation of RNA biosynthetic process
E5554_RS14455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5554_RS14465	COG2252	PERMEase
E5554_RS14475	COG3956	TIGRFAM MazG family protein
E5554_RS14480	COG1132	(ABC) transporter
E5554_RS14515	COG1482	cell wall glycoprotein biosynthetic process
E5554_RS14530	COG0438	transferase activity, transferring glycosyl groups
E5554_RS14540	COG1216	Glycosyl transferase, family 2
E5554_RS14545	COG2327	Polysaccharide pyruvyl transferase
E5554_RS14550	COG0463	Glycosyl transferase, family 2
E5554_RS14555	COG0438	transferase activity, transferring glycosyl groups
E5554_RS14605	COG2244	polysaccharide biosynthetic process
E5554_RS14610	COG4191	Histidine kinase
E5554_RS14660	COG0582	viral genome integration into host DNA
E5554_RS14665	COG4957	zinc ion binding
E5554_RS14770	COG2951	lytic endotransglycosylase activity
E5554_RS14775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5554_RS14780	COG1686	Belongs to the peptidase S11 family
E5554_RS14785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5554_RS14800	COG0084	hydrolase, TatD family'
E5554_RS14815	COG0477	Major facilitator Superfamily
E5554_RS14825	COG0653	protein targeting
E5554_RS14835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5554_RS14840	COG0483	inositol monophosphate 1-phosphatase activity
E5554_RS14845	COG0625	glutathione transferase activity
E5554_RS14855	COG1074	ATP-dependent DNA helicase activity
E5554_RS14865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5554_RS14870	COG3178	'Phosphotransferase
E5554_RS14875	COG0802	atpase or kinase
E5554_RS14880	COG2205	protein histidine kinase activity
E5554_RS14885	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5554_RS14895	COG1678	Uncharacterized ACR, COG1678
E5554_RS14905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5554_RS14910	COG5001	Diguanylate cyclase
E5554_RS14910	COG5002	protein histidine kinase activity
E5554_RS14910	COG3447	MASE1 domain protein
E5554_RS14920	COG2267	carboxylic ester hydrolase activity
E5554_RS14930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5554_RS14950	COG2271	Major facilitator Superfamily
E5554_RS14955	COG3734	2-keto-3-deoxy-galactonokinase
E5554_RS14965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5554_RS14970	COG4948	Mandelate Racemase Muconate Lactonizing
E5554_RS14975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5554_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS14985	COG0579	oxidoreductase
E5554_RS14995	COG1301	dicarboxylic acid transport
E5554_RS15005	COG2204	response regulator
E5554_RS15025	COG4555	ABC transporter
E5554_RS15055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5554_RS15060	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5554_RS15080	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E5554_RS15090	COG0183	Belongs to the thiolase family
E5554_RS15095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5554_RS15100	COG0477	Major facilitator Superfamily
E5554_RS15105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5554_RS15110	COG4770	biotin carboxylase activity
E5554_RS15120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5554_RS15125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5554_RS15125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5554_RS15130	COG0346	lactoylglutathione lyase activity
E5554_RS15135	COG2827	Endonuclease containing a URI domain
E5554_RS15140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5554_RS15145	COG1396	sequence-specific DNA binding
E5554_RS15145	COG3800	Transcriptional regulator
E5554_RS15155	COG0583	DNA-binding transcription factor activity
E5554_RS15160	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS15175	COG0166	Belongs to the GPI family
E5554_RS15185	COG0571	ribonuclease III activity
E5554_RS15190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5554_RS15195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5554_RS15200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5554_RS15200	COG1754	DNA topoisomerase type I activity
E5554_RS15210	COG0758	DNA mediated transformation
E5554_RS15215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5554_RS15225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5554_RS15230	COG0156	8-amino-7-oxononanoate synthase activity
E5554_RS15240	COG2226	methyltransferase
E5554_RS15265	COG1748	Saccharopine dehydrogenase
E5554_RS15270	COG0596	Alpha beta hydrolase
E5554_RS15285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5554_RS15290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5554_RS15290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5554_RS15305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5554_RS15325	COG0741	lytic transglycosylase activity
E5554_RS15330	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5554_RS15345	COG3158	transport of potassium into the cell
E5554_RS15355	COG3088	subunit of a heme lyase
E5554_RS15360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5554_RS15365	COG1138	Cytochrome C-type biogenesis protein
E5554_RS15370	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E5554_RS15380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5554_RS15385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5554_RS15390	COG4221	oxidoreductase activity
E5554_RS15395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5554_RS15400	COG0415	Belongs to the DNA photolyase family
E5554_RS15405	COG1051	belongs to the nudix hydrolase family
E5554_RS15425	COG3724	N-succinylarginine dihydrolase activity
E5554_RS15450	COG1492	cobalamin metabolic process
E5554_RS15475	COG0052	Belongs to the universal ribosomal protein uS2 family
E5554_RS15480	COG0574	Belongs to the PEP-utilizing enzyme family
E5554_RS15480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5554_RS15485	COG0751	glycine-tRNA ligase activity
E5554_RS15490	COG0752	glycyl-tRNA synthetase alpha subunit
E5554_RS15505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5554_RS15510	COG0193	aminoacyl-tRNA hydrolase activity
E5554_RS15525	COG0033	Phosphoglucomutase
E5554_RS15540	COG0012	GTP binding
E5554_RS15565	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS15565	COG2030	dehydratase
E5554_RS15570	COG1280	lysine exporter protein (LysE YggA)
E5554_RS15575	COG2258	MOSC domain
E5554_RS15585	COG0297	glycogen (starch) synthase activity
E5554_RS15590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5554_RS15650	COG0617	tRNA 3'-terminal CCA addition
E5554_RS15655	COG2199	diguanylate cyclase activity
E5554_RS15655	COG2202	Pas domain
E5554_RS15655	COG2200	EAL domain
E5554_RS15660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5554_RS15670	COG0583	DNA-binding transcription factor activity
E5554_RS15675	COG1877	trehalose-phosphatase activity
E5554_RS15680	COG3387	PFAM Glycoside hydrolase 15-related
E5554_RS15685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5554_RS15695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5554_RS15705	COG2223	nitrite transmembrane transporter activity
E5554_RS15715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5554_RS15720	COG0047	phosphoribosylformylglycinamidine synthase activity
E5554_RS15740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5554_RS15750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5554_RS15755	COG0842	Transport permease protein
E5554_RS15775	COG0187	DNA topoisomerase II activity
E5554_RS15785	COG0583	DNA-binding transcription factor activity
E5554_RS15790	COG2967	ApaG domain
E5554_RS15800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5554_RS15810	COG0473	3-isopropylmalate dehydrogenase activity
E5554_RS15815	COG1381	Involved in DNA repair and RecF pathway recombination
E5554_RS15845	COG0322	excinuclease ABC activity
E5554_RS15850	COG1064	alcohol dehydrogenase
E5554_RS15865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5554_RS15870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5554_RS15875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5554_RS15880	COG0356	it plays a direct role in the translocation of protons across the membrane
E5554_RS15910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5554_RS16170	COG0513	Belongs to the DEAD box helicase family
E5554_RS16180	COG0277	FAD linked oxidase domain protein
E5554_RS16205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5554_RS16270	COG1475	DNA binding
E5554_RS16280	COG3001	Fructosamine kinase
E5554_RS16305	COG0776	regulation of translation
E5554_RS16315	COG3916	Acyl-homoserine-lactone synthase
E5554_RS16410	COG1595	DNA-templated transcription, initiation
E5554_RS16425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5554_RS16465	COG1506	peptidase
E5554_RS16465	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS16615	COG0583	DNA-binding transcription factor activity
E5554_RS16620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5554_RS16645	COG2351	hydroxyisourate hydrolase activity
E5554_RS16650	COG2072	flavoprotein involved in K transport
E5554_RS16665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5554_RS16700	COG2233	PERMEase
E5554_RS16705	COG4771	TonB-dependent receptor
E5554_RS16710	COG0583	DNA-binding transcription factor activity
E5554_RS16725	COG3153	acetyltransferase
E5554_RS16725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5554_RS16745	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5554_RS16755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5554_RS16760	COG0583	DNA-binding transcription factor activity
E5554_RS16870	COG0297	glycogen (starch) synthase activity
E5554_RS16880	COG0745	RESPONSE REGULATOR receiver
E5554_RS16905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5554_RS16920	COG2197	response regulator
E5554_RS16935	COG4181	ATPase activity
E5554_RS17015	COG4771	TonB-dependent receptor
E5554_RS17020	COG1049	propionate catabolic process, 2-methylcitrate cycle
E5554_RS17025	COG3119	arylsulfatase activity
E5554_RS17075	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS17085	COG0557	exoribonuclease II activity
E5554_RS17100	COG0659	secondary active sulfate transmembrane transporter activity
E5554_RS17110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5554_RS17115	COG0134	indole-3-glycerol-phosphate synthase activity
E5554_RS17120	COG0315	cyclic pyranopterin monophosphate synthase activity
E5554_RS17130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5554_RS17135	COG2333	competence protein COMEC
E5554_RS17135	COG0658	competence protein
E5554_RS17140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5554_RS17145	COG0372	Belongs to the citrate synthase family
E5554_RS17155	COG2205	protein histidine kinase activity
E5554_RS17180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5554_RS17185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5554_RS17200	COG2852	Protein conserved in bacteria
E5554_RS17205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5554_RS17215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5554_RS17240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5554_RS17245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5554_RS17290	COG4771	TonB-dependent receptor
E5554_RS17295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5554_RS17305	COG0235	Class ii aldolase
E5554_RS17315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5554_RS17330	COG1116	anion transmembrane transporter activity
E5554_RS17335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5554_RS17340	COG0583	DNA-binding transcription factor activity
E5554_RS17345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5554_RS17365	COG4677	pectinesterase activity
E5554_RS17380	COG2271	Major facilitator Superfamily
E5554_RS17390	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E5554_RS17395	COG3250	beta-galactosidase activity
E5554_RS17470	COG2860	membrane
E5554_RS17480	COG0386	Belongs to the glutathione peroxidase family
E5554_RS17490	COG0488	(ABC) transporter
E5554_RS17520	COG2832	Protein of unknown function (DUF454)
E5554_RS17530	COG1058	Belongs to the CinA family
E5554_RS17530	COG1546	Belongs to the CinA family
E5554_RS17540	COG0024	Methionine aminopeptidase
E5554_RS17545	COG0347	Belongs to the P(II) protein family
E5554_RS17550	COG0174	glutamine synthetase
E5554_RS17560	COG2070	2-Nitropropane dioxygenase
E5554_RS17580	COG0564	pseudouridine synthase activity
E5554_RS17585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5554_RS17615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5554_RS17620	COG0740	serine-type endopeptidase activity
E5554_RS17640	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5554_RS17660	COG3712	iron ion homeostasis
E5554_RS17685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5554_RS17690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5554_RS17715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5554_RS17720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5554_RS17725	COG1309	transcriptional regulator
E5554_RS17730	COG1228	amidohydrolase
E5554_RS17735	COG0612	Peptidase, M16
E5554_RS17740	COG0513	Belongs to the DEAD box helicase family
E5554_RS17750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E5554_RS17760	COG1214	PFAM Peptidase M22, glycoprotease
E5554_RS17760	COG0456	acetyltransferase
E5554_RS17765	COG4957	zinc ion binding
E5554_RS17780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5554_RS17785	COG1702	phosphate starvation-inducible protein PhoH
E5554_RS17790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5554_RS17795	COG1253	flavin adenine dinucleotide binding
E5554_RS17805	COG0671	phosphoesterase, PA-phosphatase related
E5554_RS17810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5554_RS17815	COG1607	acyl-coa hydrolase
E5554_RS17820	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5554_RS17860	COG1335	isochorismatase
E5554_RS17865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5554_RS17870	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5554_RS17875	COG2080	2 iron, 2 sulfur cluster binding
E5554_RS17905	COG3153	acetyltransferase
E5554_RS17905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5554_RS17930	COG1136	(ABC) transporter
E5554_RS17940	COG0071	Belongs to the small heat shock protein (HSP20) family
E5554_RS17950	COG0698	ribose 5-phosphate isomerase
E5554_RS17955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5554_RS17960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5554_RS17975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5554_RS17990	COG0754	glutathionylspermidine amidase activity
E5554_RS18020	COG1742	UPF0060 membrane protein
E5554_RS18025	COG1573	uracil-dna glycosylase
E5554_RS18045	COG3401	FG-GAP repeat protein
E5554_RS18050	COG3250	beta-galactosidase activity
E5554_RS18070	COG0673	inositol 2-dehydrogenase activity
E5554_RS18090	COG1523	belongs to the glycosyl hydrolase 13 family
E5554_RS18095	COG0297	glycogen (starch) synthase activity
E5554_RS18100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5554_RS18105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5554_RS18110	COG0058	SHG alpha-glucan phosphorylase activity
E5554_RS18150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5554_RS18155	COG0154	amidase activity
E5554_RS18160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5554_RS18170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5554_RS18180	COG0789	Transcriptional regulator
E5554_RS18200	COG3830	Belongs to the UPF0237 family
E5554_RS18200	COG0560	Phosphoserine phosphatase
E5554_RS18205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5554_RS18210	COG0028	Belongs to the TPP enzyme family
E5554_RS18220	COG0440	acetolactate synthase activity
E5554_RS18225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5554_RS18230	COG2353	YceI-like domain
E5554_RS18240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5554_RS18245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5554_RS18265	COG0251	oxidation-reduction process
E5554_RS18295	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E5554_RS18325	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5554_RS18325	COG0022	dehydrogenase e1 component
E5554_RS18330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5554_RS18340	COG0148	phosphopyruvate hydratase activity
E5554_RS18375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5554_RS18390	COG0505	Belongs to the CarA family
E5554_RS18395	COG1610	YqeY-like protein
E5554_RS18405	COG0358	DNA primase activity
E5554_RS18410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5554_RS18420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5554_RS18435	COG3739	integral membrane protein
E5554_RS18465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E5554_RS18475	COG1007	ATP synthesis coupled electron transport
E5554_RS18490	COG0713	ATP synthesis coupled electron transport
E5554_RS18500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5554_RS18505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5554_RS18515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5554_RS18520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E5554_RS18525	COG0649	NAD binding
E5554_RS18530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5554_RS18535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5554_RS18540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5554_RS18545	COG0483	inositol monophosphate 1-phosphatase activity
E5554_RS18555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5554_RS18560	COG4942	peptidase
E5554_RS18565	COG1376	ErfK ybiS ycfS ynhG family protein
E5554_RS18575	COG0352	thiamine-phosphate diphosphorylase activity
E5554_RS18590	COG3588	fructose-bisphosphate aldolase
E5554_RS18595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5554_RS18600	COG2814	Major facilitator Superfamily
E5554_RS18605	COG0126	phosphoglycerate kinase activity
E5554_RS18610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5554_RS18630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5554_RS18655	COG0628	permease
E5554_RS18680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5554_RS18740	COG0656	L-ascorbic acid biosynthetic process
E5554_RS18745	COG1309	transcriptional regulator
E5554_RS18765	COG0693	protein deglycase activity
E5554_RS18785	COG4221	oxidoreductase activity
E5554_RS18795	COG1902	pentaerythritol trinitrate reductase activity
E5554_RS18820	COG0210	DNA helicase
E5554_RS18875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5554_RS18885	COG2003	Belongs to the UPF0758 family
E5554_RS18895	COG3920	Histidine kinase
E5554_RS18895	COG2202	Pas domain
E5554_RS18900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5554_RS18905	COG2205	protein histidine kinase activity
E5554_RS18905	COG4999	Histidine kinase
E5554_RS18905	COG3850	Histidine kinase
E5554_RS18905	COG3437	response regulator, receiver
E5554_RS18915	COG1846	Transcriptional regulator
E5554_RS18920	COG1764	response to oxidative stress
E5554_RS18930	COG1522	sequence-specific DNA binding
E5554_RS18950	COG3250	beta-galactosidase activity
E5554_RS18955	COG0246	Mannitol dehydrogenase
E5554_RS18960	COG2271	Major facilitator Superfamily
E5554_RS18965	COG4948	Mandelate Racemase Muconate Lactonizing
E5554_RS18970	COG1472	Belongs to the glycosyl hydrolase 3 family
E5554_RS18975	COG1472	Belongs to the glycosyl hydrolase 3 family
E5554_RS18980	COG3661	Belongs to the glycosyl hydrolase 67 family
E5554_RS19000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5554_RS19030	COG0477	Major facilitator Superfamily
E5554_RS19045	COG0284	orotidine-5'-phosphate decarboxylase activity
E5554_RS19065	COG1760	l-serine dehydratase
E5554_RS19075	COG0729	surface antigen
E5554_RS19115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5554_RS19120	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5554_RS19130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5554_RS19135	COG4206	TonB-dependent receptor
E5554_RS19140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5554_RS19155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5554_RS19195	COG0009	L-threonylcarbamoyladenylate synthase
E5554_RS19205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5554_RS19210	COG0318	PFAM AMP-dependent synthetase and ligase
E5554_RS19220	COG0438	transferase activity, transferring glycosyl groups
E5554_RS19265	COG0823	Involved in the tonB-independent uptake of proteins
E5554_RS19265	COG1506	peptidase
E5554_RS19265	COG4946	Tricorn protease homolog
E5554_RS19275	COG0670	Belongs to the BI1 family
E5554_RS19290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5554_RS19310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5554_RS19345	COG3104	oligopeptide transport
E5554_RS19350	COG0778	Nitroreductase
E5554_RS19355	COG2188	Transcriptional regulator
E5554_RS19365	COG2204	response regulator
E5554_RS19370	COG4191	Histidine kinase
E5554_RS19375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5554_RS19390	COG0784	Response regulator, receiver
E5554_RS19405	COG0343	queuine tRNA-ribosyltransferase activity
E5554_RS19415	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5554_RS19415	COG1024	Enoyl-CoA hydratase
E5554_RS19420	COG5001	Diguanylate cyclase
E5554_RS19420	COG3300	MHYT domain
E5554_RS19425	COG0459	protein refolding
E5554_RS19430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5554_RS19445	COG0589	response to stress
E5554_RS19450	COG0625	glutathione transferase activity
E5554_RS19455	COG2910	NAD(P)H-binding
E5554_RS19475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5554_RS19490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5554_RS19500	COG1185	polyribonucleotide nucleotidyltransferase activity
E5554_RS19505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5554_RS19510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5554_RS19525	COG1435	thymidine kinase activity
E5554_RS19540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5554_RS19555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5554_RS19565	COG1942	4-Oxalocrotonate Tautomerase
E5554_RS19575	COG0779	Required for maturation of 30S ribosomal subunits
E5554_RS19590	COG2133	pyrroloquinoline quinone binding
E5554_RS19605	COG1902	pentaerythritol trinitrate reductase activity
E5554_RS19610	COG0504	CTP synthase activity
E5554_RS19620	COG0149	triose-phosphate isomerase activity
E5554_RS19630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5554_RS19660	COG0300	oxidoreductase activity
E5554_RS19675	COG3022	response to hydroperoxide
E5554_RS19685	COG0667	Aldo Keto reductase
E5554_RS19700	COG2301	Belongs to the HpcH HpaI aldolase family
E5554_RS19705	COG2030	dehydratase
E5554_RS19720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5554_RS19730	COG1960	acyl-CoA dehydrogenase activity
E5554_RS19735	COG0583	DNA-binding transcription factor activity
E5554_RS19755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5554_RS19765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5554_RS19770	COG0142	geranyltranstransferase activity
E5554_RS19775	COG1722	exodeoxyribonuclease VII activity
E5554_RS19790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5554_RS19800	COG3507	Belongs to the glycosyl hydrolase 43 family
E5554_RS19805	COG4106	trans-aconitate 2-methyltransferase activity
E5554_RS19805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5554_RS19810	COG2311	Membrane
E5554_RS19825	COG0494	nUDIX hydrolase
E5554_RS19845	COG0825	malonyl-CoA metabolic process
E5554_RS19850	COG4974	Belongs to the 'phage' integrase family
E5554_RS19865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5554_RS19870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5554_RS19875	COG0254	rRNA binding
E5554_RS19880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5554_RS19890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5554_RS19895	COG0750	zinc metalloprotease
E5554_RS19900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5554_RS19910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5554_RS19915	COG0233	cytoplasmic translational termination
E5554_RS19920	COG0528	UMP kinase activity
E5554_RS19925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5554_RS19930	COG0052	Belongs to the universal ribosomal protein uS2 family
E5554_RS19940	COG1183	phosphatidylcholine synthase activity
E5554_RS19945	COG0688	phosphatidylethanolamine metabolic process
E5554_RS19950	COG0538	isocitrate dehydrogenase activity
E5554_RS19955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5554_RS19955	COG3153	acetyltransferase
E5554_RS19960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5554_RS19965	COG1408	metallophosphoesterase
E5554_RS19970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5554_RS19975	COG0546	phosphoglycolate phosphatase activity
E5554_RS19980	COG1024	Enoyl-CoA hydratase
E5554_RS19995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5554_RS20000	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5554_RS20005	COG0567	Dehydrogenase, E1 component
E5554_RS20010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5554_RS20015	COG0039	L-malate dehydrogenase activity
E5554_RS20020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5554_RS20030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5554_RS20065	COG1213	nucleotidyl transferase
E5554_RS20085	COG0739	heme binding
E5554_RS20100	COG3713	MltA-interacting MipA family protein
E5554_RS20105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5554_RS20110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5554_RS20125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5554_RS20130	COG0248	Ppx GppA phosphatase
E5554_RS20135	COG2835	tetraacyldisaccharide 4'-kinase activity
E5554_RS20140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5554_RS20170	COG0077	Prephenate dehydratase
E5554_RS20170	COG1605	Chorismate mutase
E5554_RS20185	COG1253	flavin adenine dinucleotide binding
E5554_RS20195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5554_RS20200	COG1329	Transcriptional regulator
E5554_RS20205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5554_RS20215	COG0252	asparaginase activity
E5554_RS20235	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E5554_RS20240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5554_RS20245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5554_RS20250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E5554_RS20265	COG1045	serine acetyltransferase
E5554_RS20270	COG2205	protein histidine kinase activity
E5554_RS20285	COG0659	secondary active sulfate transmembrane transporter activity
E5554_RS20370	COG4771	TonB-dependent receptor
E5554_RS20385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5554_RS20390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5554_RS20400	COG2226	methyltransferase
E5554_RS20405	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E5554_RS20415	COG0583	DNA-binding transcription factor activity
E5554_RS20420	COG2203	Gaf domain
E5554_RS20420	COG3706	GGDEF domain
E5554_RS20420	COG4251	negative regulation of phosphorylation
E5554_RS20420	COG5001	Diguanylate cyclase
E5554_RS20425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5554_RS20430	COG1597	lipid kinase activity
E5554_RS20460	COG0456	acetyltransferase
E5554_RS20465	COG0583	DNA-binding transcription factor activity
E5554_RS20475	COG3781	membrane
E5554_RS20495	COG0316	Belongs to the HesB IscA family
E5554_RS20500	COG4942	peptidase
E5554_RS20505	COG2833	Protein of unknown function (DUF455)
E5554_RS20510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5554_RS20515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5554_RS20530	COG2321	neutral zinc metallopeptidase
E5554_RS20540	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS20545	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS20560	COG0531	amino acid
E5554_RS20570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5554_RS20575	COG0351	phosphomethylpyrimidine kinase
E5554_RS20575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5554_RS20575	COG0352	thiamine-phosphate diphosphorylase activity
E5554_RS20580	COG3813	Protein conserved in bacteria
E5554_RS20585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5554_RS20590	COG1115	amino acid carrier protein
E5554_RS20595	COG3237	CsbD-like
E5554_RS20605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5554_RS20610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5554_RS20620	COG1324	tolerance protein
E5554_RS20625	COG1612	heme a metabolic process
E5554_RS20630	COG0784	Response regulator, receiver
E5554_RS20630	COG4191	Histidine kinase
E5554_RS20635	COG0800	Aldolase
E5554_RS20640	COG3734	2-keto-3-deoxy-galactonokinase
E5554_RS20645	COG0129	dihydroxy-acid dehydratase activity
E5554_RS20665	COG2186	Transcriptional regulator
E5554_RS20675	COG1132	(ABC) transporter
E5554_RS20730	COG4771	TonB-dependent receptor
E5554_RS20765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5554_RS20770	COG1420	regulation of RNA biosynthetic process
E5554_RS20790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5554_RS20795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5554_RS20815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5554_RS20825	COG3682	Transcriptional regulator
E5554_RS20830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5554_RS20845	COG0066	3-isopropylmalate dehydratase activity
E5554_RS20850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5554_RS20885	COG0477	Major facilitator Superfamily
E5554_RS20915	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS20920	COG1309	transcriptional regulator
E5554_RS20930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5554_RS20960	COG0573	inorganic phosphate transmembrane transporter activity
E5554_RS20965	COG0581	inorganic phosphate transmembrane transporter activity
E5554_RS20970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5554_RS20975	COG0704	Plays a role in the regulation of phosphate uptake
E5554_RS20980	COG0745	RESPONSE REGULATOR receiver
E5554_RS20985	COG0242	peptide deformylase activity
E5554_RS20990	COG1309	transcriptional regulator
E5554_RS20995	COG4638	Rieske (2fe-2S)
E5554_RS21020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E5554_RS21025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5554_RS21025	COG0517	IMP dehydrogenase activity
E5554_RS21060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5554_RS21070	COG1758	RNA polymerase activity
E5554_RS21100	COG3850	Histidine kinase
E5554_RS21100	COG0642	Histidine kinase
E5554_RS21105	COG0745	RESPONSE REGULATOR receiver
E5554_RS21110	COG0730	response to heat
E5554_RS21115	COG0686	Belongs to the AlaDH PNT family
E5554_RS21120	COG1522	sequence-specific DNA binding
E5554_RS21145	COG1222	aaa ATPase
E5554_RS21260	COG2197	response regulator
E5554_RS21285	COG0642	Histidine kinase
E5554_RS21290	COG0745	RESPONSE REGULATOR receiver
E5554_RS21305	COG2084	Dehydrogenase
E5554_RS21310	COG4948	Mandelate Racemase Muconate Lactonizing
E5554_RS21315	COG2271	Major facilitator Superfamily
E5554_RS21330	COG2186	Transcriptional regulator
E5554_RS21335	COG0668	transmembrane transport
E5554_RS21340	COG0477	Major facilitator Superfamily
E5554_RS21350	COG0527	aspartate kinase activity
E5554_RS21355	COG5285	phytanoyl-CoA dioxygenase
E5554_RS21360	COG1917	Cupin 2, conserved barrel domain protein
E5554_RS21365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5554_RS21410	COG4999	Histidine kinase
E5554_RS21410	COG2205	protein histidine kinase activity
E5554_RS21410	COG3437	response regulator, receiver
E5554_RS21410	COG3850	Histidine kinase
E5554_RS21440	COG2843	Capsule synthesis protein
E5554_RS21455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5554_RS21470	COG2814	Major facilitator Superfamily
E5554_RS21475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5554_RS21480	COG3659	wide pore channel activity
E5554_RS21485	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E5554_RS21485	COG1082	Xylose isomerase domain protein TIM barrel
E5554_RS21530	COG4206	TonB-dependent receptor
E5554_RS21535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5554_RS21575	COG2095	MarC family integral membrane protein
E5554_RS21585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5554_RS21590	COG1872	DUF167
E5554_RS21605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5554_RS21615	COG2205	protein histidine kinase activity
E5554_RS21615	COG2202	Pas domain
E5554_RS21635	COG1012	belongs to the aldehyde dehydrogenase family
E5554_RS21645	COG2205	protein histidine kinase activity
E5554_RS21705	COG3265	gluconokinase activity
E5554_RS21715	COG3254	rhamnose metabolic process
E5554_RS21720	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS21725	COG2721	sulfolactate sulfo-lyase activity
E5554_RS21745	COG0738	Major facilitator superfamily
E5554_RS21760	COG0657	acetylesterase activity
E5554_RS21760	COG2755	lipolytic protein G-D-S-L family
E5554_RS21780	COG1501	Belongs to the glycosyl hydrolase 31 family
E5554_RS21780	COG1501	Belongs to the glycosyl hydrolase 31 family
E5554_RS21785	COG2723	6-phospho-beta-galactosidase activity
E5554_RS21795	COG1522	sequence-specific DNA binding
E5554_RS21810	COG1082	Xylose isomerase domain protein TIM barrel
E5554_RS21815	COG0366	Alpha amylase catalytic
E5554_RS21825	COG1609	Transcriptional regulator
E5554_RS21850	COG0842	Transport permease protein
E5554_RS21855	COG1129	ABC transporter
E5554_RS21855	COG0842	Transport permease protein
E5554_RS21860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5554_RS21895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5554_RS21905	COG4566	intracellular signal transduction
E5554_RS21920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5554_RS21935	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5554_RS21940	COG4206	TonB-dependent receptor
E5554_RS21965	COG3940	Belongs to the glycosyl hydrolase 43 family
E5554_RS21995	COG2159	amidohydrolase
E5554_RS22005	COG0583	DNA-binding transcription factor activity
E5554_RS22010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5554_RS22020	COG3618	amidohydrolase
E5554_RS22040	COG1024	Enoyl-CoA hydratase
E5554_RS22055	COG0583	DNA-binding transcription factor activity
E5554_RS22080	COG0714	Associated with various cellular activities
E5554_RS22100	COG3128	pkhd-type hydroxylase
E5554_RS22115	COG1028	Short-chain dehydrogenase reductase Sdr
E5554_RS22120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5554_RS22130	COG1832	CoA-binding protein
E5554_RS22140	COG0454	-acetyltransferase
E5554_RS22145	COG0489	protein tyrosine kinase activity
E5554_RS22150	COG0330	HflC and HflK could
E5554_RS22155	COG0330	HflC and HflK could
E5554_RS22165	COG0433	COG0433 Predicted ATPase
E5554_RS22170	COG2814	Major facilitator Superfamily
E5554_RS22195	COG3119	arylsulfatase activity
E5554_RS22200	COG0085	RNA polymerase activity
E5554_RS22205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5554_RS22250	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5554_RS22255	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5554_RS22260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E5554_RS22265	COG2205	protein histidine kinase activity
E5554_RS22270	COG0745	RESPONSE REGULATOR receiver
E5554_RS22275	COG3158	transport of potassium into the cell
E5554_RS22295	COG0745	RESPONSE REGULATOR receiver
E5554_RS22300	COG5002	protein histidine kinase activity
E5554_RS22305	COG3386	PFAM SMP-30 Gluconolaconase
E5554_RS22320	COG2186	Transcriptional regulator
E5554_RS22345	COG3940	Belongs to the glycosyl hydrolase 43 family
E5554_RS22390	COG3104	oligopeptide transport
E5554_RS22395	COG1228	amidohydrolase
E5554_RS22405	COG0402	S-adenosylhomocysteine deaminase activity
E5554_RS22415	COG1940	carbohydrate kinase activity
E5554_RS22420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5554_RS22430	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E5554_RS22440	COG0402	S-adenosylhomocysteine deaminase activity
E5554_RS22445	COG0583	DNA-binding transcription factor activity
E5554_RS22465	COG4221	oxidoreductase activity
E5554_RS22470	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E5554_RS22490	COG2132	Multicopper oxidase
E5554_RS22515	COG3250	beta-galactosidase activity
E5554_RS22525	COG4771	TonB-dependent receptor
E5554_RS22530	COG0583	DNA-binding transcription factor activity
E5554_RS22535	COG4771	TonB-dependent receptor
E5554_RS22540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5554_RS22545	COG3047	cAMP biosynthetic process
E5554_RS22560	COG4191	Histidine kinase
E5554_RS22565	COG4566	intracellular signal transduction
E5554_RS22570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5554_RS22575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5554_RS22585	COG0194	GDP metabolic process
E5554_RS22615	COG0131	Imidazoleglycerol-phosphate dehydratase
E5554_RS22625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5554_RS22630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5554_RS22635	COG0107	imidazoleglycerol-phosphate synthase activity
E5554_RS22645	COG0140	phosphoribosyl-ATP diphosphatase activity
E5554_RS22655	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5554_RS22660	COG2989	Protein conserved in bacteria
E5554_RS22690	COG0546	phosphoglycolate phosphatase activity
E5554_RS22695	COG0564	pseudouridine synthase activity
E5554_RS22700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5554_RS22750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5554_RS22795	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E5554_RS22800	COG0109	protoheme IX farnesyltransferase activity
E5554_RS22805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5554_RS22815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5554_RS22820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5554_RS22825	COG0736	holo-[acyl-carrier-protein] synthase activity
E5554_RS22845	COG0545	Peptidyl-prolyl cis-trans isomerase
E5554_RS22850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5554_RS22865	COG1959	2 iron, 2 sulfur cluster binding
E5554_RS22870	COG0492	ferredoxin-NADP+ reductase activity
E5554_RS22900	COG1573	uracil-dna glycosylase
E5554_RS22905	COG0402	S-adenosylhomocysteine deaminase activity