locus-tag	class	description
SLG_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SLG_RS00010	COG0424	maF-like protein
SLG_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SLG_RS00020	COG0237	dephospho-CoA kinase activity
SLG_RS00025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SLG_RS00030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SLG_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLG_RS00060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SLG_RS00070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SLG_RS00075	COG2902	Dehydrogenase
SLG_RS00110	COG3920	Histidine kinase
SLG_RS00115	COG2268	Band 7 protein
SLG_RS00125	COG3038	cytochrome b561
SLG_RS00130	COG2255	four-way junction helicase activity
SLG_RS00140	COG0632	four-way junction helicase activity
SLG_RS00150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SLG_RS00155	COG0594	ribonuclease P activity
SLG_RS00160	COG0706	membrane insertase activity
SLG_RS00165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SLG_RS00180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLG_RS00190	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SLG_RS00200	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SLG_RS00205	COG0728	peptidoglycan biosynthetic process
SLG_RS00210	COG0180	Tryptophanyl-tRNA synthetase
SLG_RS00225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SLG_RS00230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SLG_RS00235	COG0181	hydroxymethylbilane synthase activity
SLG_RS00255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SLG_RS00275	COG0471	metal ion transport
SLG_RS00275	COG3273	potassium ion transport
SLG_RS00315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SLG_RS00325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SLG_RS00335	COG0039	L-malate dehydrogenase activity
SLG_RS00350	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLG_RS00355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLG_RS00370	COG2860	membrane
SLG_RS00380	COG0616	signal peptide processing
SLG_RS00385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SLG_RS00390	COG0459	protein refolding
SLG_RS00430	COG0617	tRNA 3'-terminal CCA addition
SLG_RS00435	COG2203	Gaf domain
SLG_RS00435	COG5001	Diguanylate cyclase
SLG_RS00435	COG3706	GGDEF domain
SLG_RS00435	COG4251	negative regulation of phosphorylation
SLG_RS00440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLG_RS00445	COG0113	porphobilinogen synthase activity
SLG_RS00450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLG_RS00455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SLG_RS00465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SLG_RS00470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SLG_RS00480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLG_RS00490	COG0477	Major facilitator Superfamily
SLG_RS00495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SLG_RS00500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SLG_RS00520	COG0156	8-amino-7-oxononanoate synthase activity
SLG_RS00545	COG0456	acetyltransferase
SLG_RS00560	COG0004	ammonium transporteR
SLG_RS00570	COG0077	Prephenate dehydratase
SLG_RS00570	COG1605	Chorismate mutase
SLG_RS00575	COG3474	cytochrome
SLG_RS00580	COG1611	Belongs to the LOG family
SLG_RS00590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SLG_RS00595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SLG_RS00600	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SLG_RS00625	COG1305	Transglutaminase-like
SLG_RS00630	COG0268	Binds directly to 16S ribosomal RNA
SLG_RS00640	COG0628	permease
SLG_RS00645	COG1393	Belongs to the ArsC family
SLG_RS00655	COG1959	2 iron, 2 sulfur cluster binding
SLG_RS00660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SLG_RS00670	COG0659	secondary active sulfate transmembrane transporter activity
SLG_RS00675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SLG_RS00680	COG0215	cysteine-tRNA ligase activity
SLG_RS00690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SLG_RS00695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SLG_RS00725	COG4269	membrane
SLG_RS00730	COG0501	Belongs to the peptidase M48B family
SLG_RS00735	COG3920	Histidine kinase
SLG_RS00735	COG2202	Pas domain
SLG_RS00750	COG1022	Amp-dependent synthetase and ligase
SLG_RS00755	COG0405	Gamma-glutamyltransferase
SLG_RS00770	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SLG_RS00775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLG_RS00790	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SLG_RS00810	COG0138	bifunctional purine biosynthesis protein purh
SLG_RS00825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLG_RS00825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SLG_RS00830	COG1304	FMN binding
SLG_RS00835	COG0587	DNA-directed DNA polymerase activity
SLG_RS00855	COG0861	Integral membrane protein TerC family
SLG_RS00860	COG0670	Belongs to the BI1 family
SLG_RS00875	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SLG_RS00885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLG_RS00890	COG0165	Argininosuccinate lyase
SLG_RS00900	COG0019	diaminopimelate decarboxylase activity
SLG_RS00905	COG1648	precorrin-2 dehydrogenase activity
SLG_RS00905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SLG_RS00920	COG0823	Involved in the tonB-independent uptake of proteins
SLG_RS00920	COG1506	peptidase
SLG_RS00920	COG4946	Tricorn protease homolog
SLG_RS00930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SLG_RS00995	COG5265	(ABC) transporter
SLG_RS01005	COG2066	Belongs to the glutaminase family
SLG_RS01010	COG1301	dicarboxylic acid transport
SLG_RS01015	COG2814	Major facilitator Superfamily
SLG_RS01020	COG2813	Specifically methylates the guanine in position
SLG_RS01020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLG_RS01030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLG_RS01035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SLG_RS01040	COG0287	Prephenate dehydrogenase
SLG_RS01050	COG0557	exoribonuclease II activity
SLG_RS01055	COG0668	transmembrane transport
SLG_RS01065	COG2171	N-acyltransferase activity
SLG_RS01075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SLG_RS01085	COG2205	protein histidine kinase activity
SLG_RS01125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLG_RS01135	COG0151	Belongs to the GarS family
SLG_RS01140	COG1570	exodeoxyribonuclease VII activity
SLG_RS01185	COG0542	response to heat
SLG_RS01190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SLG_RS01195	COG0612	Peptidase, M16
SLG_RS01210	COG2885	chlorophyll binding
SLG_RS01215	COG0823	Involved in the tonB-independent uptake of proteins
SLG_RS01235	COG0824	Thioesterase
SLG_RS01250	COG0131	Imidazoleglycerol-phosphate dehydratase
SLG_RS01255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SLG_RS01260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SLG_RS01265	COG0107	imidazoleglycerol-phosphate synthase activity
SLG_RS01275	COG0140	phosphoribosyl-ATP diphosphatase activity
SLG_RS01285	COG0531	amino acid
SLG_RS01290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SLG_RS01295	COG0432	Pfam Uncharacterised protein family UPF0047
SLG_RS01305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SLG_RS01310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SLG_RS01315	COG1295	ribonuclease BN
SLG_RS01320	COG0484	heat shock protein binding
SLG_RS01330	COG0259	pyridoxamine-phosphate oxidase activity
SLG_RS01335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SLG_RS01355	COG2354	Protein conserved in bacteria
SLG_RS01360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SLG_RS01380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SLG_RS01385	COG1684	flagellar biosynthetic protein fliR
SLG_RS01440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SLG_RS01450	COG1677	Flagellar hook-basal body complex protein FliE
SLG_RS01465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SLG_RS01475	COG0842	Transport permease protein
SLG_RS01480	COG0842	Transport permease protein
SLG_RS01485	COG1131	(ABC) transporter
SLG_RS01495	COG1309	transcriptional regulator
SLG_RS01520	COG2205	protein histidine kinase activity
SLG_RS01525	COG3708	Transcriptional regulator
SLG_RS01525	COG2207	Transcriptional regulator
SLG_RS01540	COG1454	alcohol dehydrogenase
SLG_RS01545	COG0454	-acetyltransferase
SLG_RS01550	COG1253	flavin adenine dinucleotide binding
SLG_RS01555	COG2885	chlorophyll binding
SLG_RS01560	COG1607	acyl-coa hydrolase
SLG_RS01575	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLG_RS01580	COG0789	Transcriptional regulator
SLG_RS01585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SLG_RS01595	COG1473	amidohydrolase
SLG_RS01605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SLG_RS01620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SLG_RS01630	COG2095	MarC family integral membrane protein
SLG_RS01635	COG3384	dioxygenase
SLG_RS01655	COG3384	dioxygenase
SLG_RS01675	COG2824	Alkylphosphonate utilization operon protein PhnA
SLG_RS01705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SLG_RS01720	COG0135	phosphoribosylanthranilate isomerase activity
SLG_RS01730	COG0662	Cupin 2, conserved barrel domain protein
SLG_RS01730	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SLG_RS01755	COG4964	Belongs to the GSP D family
SLG_RS01785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLG_RS01800	COG0343	queuine tRNA-ribosyltransferase activity
SLG_RS01820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLG_RS01820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLG_RS01830	COG0217	transcriptional regulatory protein
SLG_RS01835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SLG_RS01865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SLG_RS01870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLG_RS01885	COG5001	Diguanylate cyclase
SLG_RS01885	COG1716	ATPase activity
SLG_RS01900	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SLG_RS01920	COG0484	heat shock protein binding
SLG_RS01935	COG2423	ornithine cyclodeaminase activity
SLG_RS01945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLG_RS01950	COG3023	N-Acetylmuramoyl-L-alanine amidase
SLG_RS01955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SLG_RS01960	COG2201	protein-glutamate methylesterase activity
SLG_RS01965	COG0745	RESPONSE REGULATOR receiver
SLG_RS01975	COG0643	Histidine kinase
SLG_RS01975	COG0784	Response regulator, receiver
SLG_RS01975	COG2198	Histidine kinase
SLG_RS01990	COG0564	pseudouridine synthase activity
SLG_RS01995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SLG_RS02010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SLG_RS02015	COG0564	pseudouridine synthase activity
SLG_RS02025	COG2271	Major facilitator Superfamily
SLG_RS02030	COG0625	glutathione transferase activity
SLG_RS02060	COG2884	Cell division ATP-binding protein ftsE
SLG_RS02070	COG0534	Mate efflux family protein
SLG_RS02090	COG0243	molybdopterin cofactor binding
SLG_RS02095	COG0730	response to heat
SLG_RS02100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SLG_RS02105	COG1058	Belongs to the CinA family
SLG_RS02105	COG1546	Belongs to the CinA family
SLG_RS02120	COG1285	pathogenesis
SLG_RS02125	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SLG_RS02175	COG4993	Dehydrogenase
SLG_RS02210	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SLG_RS02215	COG3387	PFAM Glycoside hydrolase 15-related
SLG_RS02220	COG1877	trehalose-phosphatase activity
SLG_RS02225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SLG_RS02230	COG4166	transmembrane transport
SLG_RS02235	COG4166	transmembrane transport
SLG_RS02240	COG4174	ABC transporter (Permease)
SLG_RS02245	COG4239	(ABC) transporter, permease
SLG_RS02250	COG4172	Belongs to the ABC transporter superfamily
SLG_RS02260	COG0194	GDP metabolic process
SLG_RS02280	COG2249	NAD(P)H dehydrogenase (quinone) activity
SLG_RS02305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SLG_RS02305	COG1372	Participates in initiation and elongation during chromosome replication
SLG_RS02325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SLG_RS02325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SLG_RS02335	COG2814	Major facilitator Superfamily
SLG_RS02340	COG0840	transmembrane signaling receptor activity
SLG_RS02355	COG2801	Transposase and inactivated derivatives
SLG_RS02355	COG3415	Transposase
SLG_RS02375	COG2261	transglycosylase associated protein
SLG_RS02405	COG0556	nucleotide-excision repair
SLG_RS02410	COG0583	DNA-binding transcription factor activity
SLG_RS02435	COG2733	membrane
SLG_RS02450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SLG_RS02460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SLG_RS02465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SLG_RS02470	COG1420	regulation of RNA biosynthetic process
SLG_RS02475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SLG_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS02495	COG0393	Putative heavy-metal-binding
SLG_RS02500	COG3750	Belongs to the UPF0335 family
SLG_RS02505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SLG_RS02515	COG0513	Belongs to the DEAD box helicase family
SLG_RS02540	COG0469	pyruvate kinase activity
SLG_RS02570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SLG_RS02580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SLG_RS02595	COG2866	Carboxypeptidase
SLG_RS02600	COG0024	Methionine aminopeptidase
SLG_RS02625	COG0588	phosphoglycerate mutase activity
SLG_RS02640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SLG_RS02650	COG0196	riboflavin kinase activity
SLG_RS02665	COG3713	MltA-interacting MipA family protein
SLG_RS02680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SLG_RS02685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SLG_RS02705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SLG_RS02730	COG1301	dicarboxylic acid transport
SLG_RS02735	COG1960	acyl-CoA dehydrogenase activity
SLG_RS02740	COG4771	TonB-dependent receptor
SLG_RS02760	COG0339	signal peptide processing
SLG_RS02765	COG2832	Protein of unknown function (DUF454)
SLG_RS02775	COG0328	RNA-DNA hybrid ribonuclease activity
SLG_RS02780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SLG_RS02785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SLG_RS02795	COG0018	arginyl-trna synthetase
SLG_RS02805	COG1472	Belongs to the glycosyl hydrolase 3 family
SLG_RS02810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SLG_RS02815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SLG_RS02820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLG_RS02825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLG_RS02830	COG0805	protein transport
SLG_RS02840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLG_RS02860	COG0275	rRNA processing
SLG_RS02875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SLG_RS02880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SLG_RS02885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SLG_RS02890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SLG_RS02900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLG_RS02905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SLG_RS02915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SLG_RS02920	COG1181	Belongs to the D-alanine--D-alanine ligase family
SLG_RS02925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SLG_RS02935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SLG_RS02945	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SLG_RS02980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLG_RS02995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SLG_RS03005	COG2096	Adenosyltransferase
SLG_RS03015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SLG_RS03035	COG0436	Aminotransferase
SLG_RS03040	COG3243	poly(R)-hydroxyalkanoic acid synthase
SLG_RS03050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SLG_RS03060	COG1393	Belongs to the ArsC family
SLG_RS03065	COG0798	PFAM Bile acid sodium symporter
SLG_RS03070	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SLG_RS03085	COG2239	Acts as a magnesium transporter
SLG_RS03090	COG2814	Major facilitator Superfamily
SLG_RS03145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SLG_RS03165	COG4181	ATPase activity
SLG_RS03170	COG2755	lipolytic protein G-D-S-L family
SLG_RS03190	COG0511	ligase activity, forming carbon-carbon bonds
SLG_RS03190	COG5016	pyruvate
SLG_RS03195	COG0439	Biotin carboxylase
SLG_RS03200	COG0511	ligase activity, forming carbon-carbon bonds
SLG_RS03220	COG0477	Major facilitator Superfamily
SLG_RS03225	COG0662	Cupin 2, conserved barrel domain protein
SLG_RS03240	COG4771	TonB-dependent receptor
SLG_RS03305	COG3772	lysozyme
SLG_RS03325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SLG_RS03330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SLG_RS03345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLG_RS03355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SLG_RS03360	COG0416	fatty acid biosynthetic process
SLG_RS03365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLG_RS03370	COG0776	regulation of translation
SLG_RS03385	COG1199	ATP-dependent helicase activity
SLG_RS03385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SLG_RS03395	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SLG_RS03415	COG1538	Outer membrane efflux protein
SLG_RS03420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLG_RS03425	COG0842	Transport permease protein
SLG_RS03425	COG1129	ABC transporter
SLG_RS03430	COG0842	Transport permease protein
SLG_RS03435	COG0589	response to stress
SLG_RS03445	COG3685	Protein conserved in bacteria
SLG_RS03450	COG3546	catalase activity
SLG_RS03475	COG2319	Wd-40 repeat
SLG_RS03480	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS03495	COG1522	sequence-specific DNA binding
SLG_RS03515	COG1902	pentaerythritol trinitrate reductase activity
SLG_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS03530	COG0366	Alpha amylase catalytic
SLG_RS03535	COG0659	secondary active sulfate transmembrane transporter activity
SLG_RS03595	COG0702	epimerase
SLG_RS03610	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SLG_RS03630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SLG_RS03645	COG1846	Transcriptional regulator
SLG_RS03675	COG2205	protein histidine kinase activity
SLG_RS03680	COG0745	RESPONSE REGULATOR receiver
SLG_RS03685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLG_RS03690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SLG_RS03740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SLG_RS03750	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS03755	COG0667	Aldo Keto reductase
SLG_RS03765	COG1960	acyl-CoA dehydrogenase activity
SLG_RS03780	COG1024	Enoyl-CoA hydratase
SLG_RS03815	COG0473	3-isopropylmalate dehydrogenase activity
SLG_RS03815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SLG_RS03820	COG2159	amidohydrolase
SLG_RS03830	COG4638	Rieske (2fe-2S)
SLG_RS03855	COG0028	Belongs to the TPP enzyme family
SLG_RS03860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SLG_RS03870	COG1846	Transcriptional regulator
SLG_RS03875	COG1024	Enoyl-CoA hydratase
SLG_RS03965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SLG_RS03970	COG1917	Cupin 2, conserved barrel domain protein
SLG_RS03975	COG5285	phytanoyl-CoA dioxygenase
SLG_RS03980	COG0527	aspartate kinase activity
SLG_RS03990	COG0477	Major facilitator Superfamily
SLG_RS04005	COG0745	RESPONSE REGULATOR receiver
SLG_RS04020	COG1940	carbohydrate kinase activity
SLG_RS04025	COG1621	beta-fructofuranosidase activity
SLG_RS04030	COG1609	Transcriptional regulator
SLG_RS04040	COG4771	TonB-dependent receptor
SLG_RS04075	COG0235	Class ii aldolase
SLG_RS04085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SLG_RS04090	COG0545	Peptidyl-prolyl cis-trans isomerase
SLG_RS04095	COG0628	permease
SLG_RS04100	COG0681	Belongs to the peptidase S26 family
SLG_RS04105	COG0736	holo-[acyl-carrier-protein] synthase activity
SLG_RS04110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SLG_RS04115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SLG_RS04125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SLG_RS04130	COG0109	protoheme IX farnesyltransferase activity
SLG_RS04135	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SLG_RS04165	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SLG_RS04170	COG4133	protoheme IX ABC transporter activity
SLG_RS04175	COG2154	pterin-4-alpha-carbinolamine dehydratase
SLG_RS04180	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SLG_RS04185	COG0633	Ferredoxin
SLG_RS04200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLG_RS04215	COG0028	Belongs to the TPP enzyme family
SLG_RS04220	COG1846	Transcriptional regulator
SLG_RS04225	COG0058	SHG alpha-glucan phosphorylase activity
SLG_RS04230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SLG_RS04235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SLG_RS04240	COG0297	glycogen (starch) synthase activity
SLG_RS04245	COG0033	Phosphoglucomutase
SLG_RS04250	COG1523	belongs to the glycosyl hydrolase 13 family
SLG_RS04280	COG0438	transferase activity, transferring glycosyl groups
SLG_RS04290	COG0438	transferase activity, transferring glycosyl groups
SLG_RS04330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SLG_RS04335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SLG_RS04340	COG0314	molybdopterin synthase activity
SLG_RS04350	COG0583	DNA-binding transcription factor activity
SLG_RS04355	COG0730	response to heat
SLG_RS04360	COG1045	serine acetyltransferase
SLG_RS04370	COG3746	phosphate-selective porin O and P
SLG_RS04375	COG0745	RESPONSE REGULATOR receiver
SLG_RS04380	COG0704	Plays a role in the regulation of phosphate uptake
SLG_RS04385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SLG_RS04395	COG0573	inorganic phosphate transmembrane transporter activity
SLG_RS04405	COG5002	protein histidine kinase activity
SLG_RS04430	COG0546	phosphoglycolate phosphatase activity
SLG_RS04435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SLG_RS04440	COG0628	permease
SLG_RS04455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SLG_RS04460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SLG_RS04460	COG2010	Cytochrome c
SLG_RS04490	COG1597	lipid kinase activity
SLG_RS04495	COG0483	inositol monophosphate 1-phosphatase activity
SLG_RS04515	COG1295	ribonuclease BN
SLG_RS04515	COG1959	2 iron, 2 sulfur cluster binding
SLG_RS04535	COG1125	glycine betaine transport
SLG_RS04540	COG1174	glycine betaine transport
SLG_RS04545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SLG_RS04550	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SLG_RS04555	COG4771	TonB-dependent receptor
SLG_RS04580	COG1396	sequence-specific DNA binding
SLG_RS04580	COG3800	Transcriptional regulator
SLG_RS04620	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS04635	COG0657	acetylesterase activity
SLG_RS04660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SLG_RS04670	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SLG_RS04675	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS04705	COG1733	regulation of RNA biosynthetic process
SLG_RS04715	COG0114	fumarate hydratase activity
SLG_RS04720	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
SLG_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS04730	COG1522	sequence-specific DNA binding
SLG_RS04735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SLG_RS04755	COG1607	acyl-coa hydrolase
SLG_RS04775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SLG_RS04785	COG1960	acyl-CoA dehydrogenase activity
SLG_RS04790	COG0583	DNA-binding transcription factor activity
SLG_RS04795	COG2910	NAD(P)H-binding
SLG_RS04805	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SLG_RS04820	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SLG_RS04860	COG5383	Protein conserved in bacteria
SLG_RS04865	COG3724	N-succinylarginine dihydrolase activity
SLG_RS04870	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS04885	COG2814	Major facilitator Superfamily
SLG_RS04900	COG1802	Transcriptional regulator
SLG_RS04915	COG0784	Response regulator, receiver
SLG_RS04920	COG3920	Histidine kinase
SLG_RS04925	COG0783	Belongs to the Dps family
SLG_RS04980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLG_RS05060	COG1640	4-alpha-glucanotransferase
SLG_RS05075	COG1793	dna ligase
SLG_RS05090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SLG_RS05100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SLG_RS05115	COG3920	Histidine kinase
SLG_RS05155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SLG_RS05180	COG2175	clavaminate synthase activity
SLG_RS05195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SLG_RS05235	COG0753	catalase activity
SLG_RS05245	COG0596	Alpha beta hydrolase
SLG_RS05250	COG4566	intracellular signal transduction
SLG_RS05255	COG4566	intracellular signal transduction
SLG_RS05260	COG4191	Histidine kinase
SLG_RS05265	COG4566	intracellular signal transduction
SLG_RS05270	COG4566	intracellular signal transduction
SLG_RS05280	COG4771	TonB-dependent receptor
SLG_RS05335	COG0583	DNA-binding transcription factor activity
SLG_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS05355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLG_RS05360	COG0430	RNA-3'-phosphate cyclase activity
SLG_RS05365	COG1690	Belongs to the RtcB family
SLG_RS05380	COG4650	regulator
SLG_RS05400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SLG_RS05405	COG1573	uracil-dna glycosylase
SLG_RS05410	COG3920	Histidine kinase
SLG_RS05410	COG2202	Pas domain
SLG_RS05415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SLG_RS05420	COG3850	Histidine kinase
SLG_RS05420	COG4999	Histidine kinase
SLG_RS05420	COG3437	response regulator, receiver
SLG_RS05420	COG2205	protein histidine kinase activity
SLG_RS05425	COG1793	dna ligase
SLG_RS05450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLG_RS05460	COG2879	small protein
SLG_RS05465	COG1966	Carbon starvation protein
SLG_RS05470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLG_RS05475	COG1999	signal sequence binding
SLG_RS05500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SLG_RS05505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLG_RS05510	COG1414	Transcriptional regulator
SLG_RS05530	COG0179	Fumarylacetoacetate (FAA) hydrolase
SLG_RS05550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SLG_RS05555	COG2368	4-hydroxyphenylacetate
SLG_RS05595	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS05655	COG2133	pyrroloquinoline quinone binding
SLG_RS05670	COG0779	Required for maturation of 30S ribosomal subunits
SLG_RS05680	COG1942	4-Oxalocrotonate Tautomerase
SLG_RS05690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SLG_RS05695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SLG_RS05700	COG1435	thymidine kinase activity
SLG_RS05710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLG_RS05725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SLG_RS05730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SLG_RS05735	COG1185	polyribonucleotide nucleotidyltransferase activity
SLG_RS05750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SLG_RS05755	COG0497	DNA recombination
SLG_RS05770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLG_RS05780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SLG_RS05785	COG1473	amidohydrolase
SLG_RS05815	COG3186	Phenylalanine-4-hydroxylase
SLG_RS05835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SLG_RS05860	COG0729	surface antigen
SLG_RS05870	COG0534	Mate efflux family protein
SLG_RS05880	COG0174	glutamine synthetase
SLG_RS05890	COG0024	Methionine aminopeptidase
SLG_RS05895	COG1546	Belongs to the CinA family
SLG_RS05895	COG1058	Belongs to the CinA family
SLG_RS05915	COG0657	acetylesterase activity
SLG_RS05925	COG2814	Major facilitator Superfamily
SLG_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS05970	COG3246	L-lysine catabolic process to acetate
SLG_RS06020	COG5265	(ABC) transporter
SLG_RS06030	COG0778	Nitroreductase
SLG_RS06035	COG5001	Diguanylate cyclase
SLG_RS06045	COG1741	Belongs to the pirin family
SLG_RS06050	COG0583	DNA-binding transcription factor activity
SLG_RS06055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SLG_RS06060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SLG_RS06085	COG2271	Major facilitator Superfamily
SLG_RS06105	COG0667	Aldo Keto reductase
SLG_RS06130	COG2159	amidohydrolase
SLG_RS06140	COG0583	DNA-binding transcription factor activity
SLG_RS06145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SLG_RS06155	COG3618	amidohydrolase
SLG_RS06170	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SLG_RS06175	COG1733	regulation of RNA biosynthetic process
SLG_RS06230	COG1063	alcohol dehydrogenase
SLG_RS06245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SLG_RS06250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SLG_RS06255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SLG_RS06285	COG2814	Major facilitator Superfamily
SLG_RS06295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLG_RS06320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SLG_RS06330	COG3383	formate dehydrogenase (NAD+) activity
SLG_RS06335	COG0746	molybdenum cofactor guanylyltransferase activity
SLG_RS06360	COG1160	GTP binding
SLG_RS06375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SLG_RS06415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SLG_RS06420	COG1815	bacterial-type flagellum-dependent cell motility
SLG_RS06425	COG1558	bacterial-type flagellum-dependent cell motility
SLG_RS06435	COG4786	Flagellar basal body rod
SLG_RS06450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SLG_RS06455	COG1706	bacterial-type flagellum-dependent cell motility
SLG_RS06510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SLG_RS06545	COG2968	Membrane
SLG_RS06550	COG0488	(ABC) transporter
SLG_RS06555	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SLG_RS06560	COG2945	thiolester hydrolase activity
SLG_RS06565	COG1104	cysteine desulfurase activity
SLG_RS06570	COG1104	cysteine desulfurase activity
SLG_RS06575	COG0633	Ferredoxin
SLG_RS06580	COG3104	oligopeptide transport
SLG_RS06585	COG0697	spore germination
SLG_RS06590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SLG_RS06595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SLG_RS06620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SLG_RS06630	COG0789	Transcriptional regulator
SLG_RS06635	COG1960	acyl-CoA dehydrogenase activity
SLG_RS06640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLG_RS06670	COG0210	DNA helicase
SLG_RS06685	COG0742	ribosomal rna small subunit methyltransferase
SLG_RS06690	COG1187	pseudouridine synthase activity
SLG_RS06695	COG0784	Response regulator, receiver
SLG_RS06695	COG0835	chemotaxis
SLG_RS06700	COG2223	nitrite transmembrane transporter activity
SLG_RS06705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SLG_RS06720	COG0285	dihydrofolate synthase activity
SLG_RS06725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SLG_RS06730	COG0159	tryptophan synthase activity
SLG_RS06740	COG0133	tryptophan synthase activity
SLG_RS06745	COG0135	phosphoribosylanthranilate isomerase activity
SLG_RS06820	COG3118	belongs to the thioredoxin family
SLG_RS06825	COG0450	alkyl hydroperoxide reductase
SLG_RS06830	COG0640	Transcriptional regulator
SLG_RS06845	COG2201	protein-glutamate methylesterase activity
SLG_RS06855	COG2198	Histidine kinase
SLG_RS06855	COG0643	Histidine kinase
SLG_RS06860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SLG_RS06865	COG2201	protein-glutamate methylesterase activity
SLG_RS06875	COG0840	transmembrane signaling receptor activity
SLG_RS06885	COG1320	monovalent cation:proton antiporter activity
SLG_RS06890	COG2212	antiporter activity
SLG_RS06900	COG0651	ATP synthesis coupled electron transport
SLG_RS06905	COG1006	Multisubunit Na H antiporter MnhC subunit
SLG_RS06910	COG2111	Na H antiporter
SLG_RS06910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLG_RS06925	COG0300	oxidoreductase activity
SLG_RS06930	COG3920	Histidine kinase
SLG_RS06935	COG2850	peptidyl-arginine hydroxylation
SLG_RS06945	COG0488	(ABC) transporter
SLG_RS06950	COG1136	(ABC) transporter
SLG_RS06965	COG1301	dicarboxylic acid transport
SLG_RS06970	COG0583	DNA-binding transcription factor activity
SLG_RS06980	COG4948	Mandelate Racemase Muconate Lactonizing
SLG_RS06990	COG1301	dicarboxylic acid transport
SLG_RS07000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SLG_RS07005	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SLG_RS07015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLG_RS07025	COG2271	Major facilitator Superfamily
SLG_RS07040	COG4771	TonB-dependent receptor
SLG_RS07050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLG_RS07075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SLG_RS07080	COG1131	(ABC) transporter
SLG_RS07085	COG0842	Transport permease protein
SLG_RS07090	COG1494	fructose-1,6-bisphosphatase
SLG_RS07135	COG1132	(ABC) transporter
SLG_RS07140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SLG_RS07145	COG1690	Belongs to the RtcB family
SLG_RS07160	COG4948	Mandelate Racemase Muconate Lactonizing
SLG_RS07175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SLG_RS07180	COG0527	aspartate kinase activity
SLG_RS07185	COG2070	2-Nitropropane dioxygenase
SLG_RS07190	COG2205	protein histidine kinase activity
SLG_RS07195	COG0802	atpase or kinase
SLG_RS07200	COG3178	'Phosphotransferase
SLG_RS07205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SLG_RS07215	COG1074	ATP-dependent DNA helicase activity
SLG_RS07225	COG0483	inositol monophosphate 1-phosphatase activity
SLG_RS07230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SLG_RS07245	COG0653	protein targeting
SLG_RS07250	COG0477	Major facilitator Superfamily
SLG_RS07260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLG_RS07265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLG_RS07265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLG_RS07270	COG1660	Displays ATPase and GTPase activities
SLG_RS07275	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SLG_RS07280	COG2205	protein histidine kinase activity
SLG_RS07285	COG0745	RESPONSE REGULATOR receiver
SLG_RS07290	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SLG_RS07300	COG0330	HflC and HflK could
SLG_RS07320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SLG_RS07330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SLG_RS07335	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SLG_RS07350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SLG_RS07365	COG0105	UTP biosynthetic process
SLG_RS07375	COG1605	Chorismate mutase
SLG_RS07375	COG0287	Prephenate dehydrogenase
SLG_RS07380	COG0142	geranyltranstransferase activity
SLG_RS07385	COG1643	Atp-dependent helicase
SLG_RS07395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SLG_RS07400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SLG_RS07415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SLG_RS07420	COG0248	Ppx GppA phosphatase
SLG_RS07430	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SLG_RS07435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SLG_RS07460	COG0741	lytic transglycosylase activity
SLG_RS07465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SLG_RS07500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SLG_RS07545	COG0587	DNA-directed DNA polymerase activity
SLG_RS07565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SLG_RS07570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SLG_RS07570	COG0475	glutathione-regulated potassium exporter activity
SLG_RS07575	COG0538	isocitrate dehydrogenase activity
SLG_RS07580	COG0688	phosphatidylethanolamine metabolic process
SLG_RS07585	COG1183	phosphatidylcholine synthase activity
SLG_RS07595	COG0052	Belongs to the universal ribosomal protein uS2 family
SLG_RS07600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SLG_RS07605	COG0528	UMP kinase activity
SLG_RS07610	COG0233	cytoplasmic translational termination
SLG_RS07615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SLG_RS07625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SLG_RS07630	COG0750	zinc metalloprotease
SLG_RS07645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SLG_RS07650	COG0254	rRNA binding
SLG_RS07660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SLG_RS07665	COG0085	RNA polymerase activity
SLG_RS07670	COG2032	superoxide dismutase activity
SLG_RS07685	COG0445	tRNA wobble uridine modification
SLG_RS07730	COG1794	racemase activity, acting on amino acids and derivatives
SLG_RS07755	COG0187	DNA topoisomerase II activity
SLG_RS07760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SLG_RS07805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLG_RS07835	COG0438	transferase activity, transferring glycosyl groups
SLG_RS07865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SLG_RS07880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SLG_RS07885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SLG_RS07920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLG_RS07940	COG0443	Heat shock 70 kDa protein
SLG_RS07945	COG0484	heat shock protein binding
SLG_RS07950	COG4221	oxidoreductase activity
SLG_RS07955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SLG_RS07960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SLG_RS07965	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SLG_RS07970	COG1138	Cytochrome C-type biogenesis protein
SLG_RS07975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLG_RS07980	COG3088	subunit of a heme lyase
SLG_RS07990	COG3158	transport of potassium into the cell
SLG_RS08015	COG2010	Cytochrome c
SLG_RS08015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLG_RS08025	COG1393	Belongs to the ArsC family
SLG_RS08035	COG0439	Biotin carboxylase
SLG_RS08040	COG0511	ligase activity, forming carbon-carbon bonds
SLG_RS08050	COG2022	thiamine diphosphate biosynthetic process
SLG_RS08065	COG2264	protein methyltransferase activity
SLG_RS08085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SLG_RS08090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLG_RS08095	COG0066	3-isopropylmalate dehydratase activity
SLG_RS08110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SLG_RS08115	COG3682	Transcriptional regulator
SLG_RS08135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SLG_RS08145	COG1505	serine-type exopeptidase activity
SLG_RS08175	COG0776	regulation of translation
SLG_RS08180	COG0539	negative regulation of cytoplasmic translation
SLG_RS08185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SLG_RS08195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SLG_RS08210	COG4638	Rieske (2fe-2S)
SLG_RS08215	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SLG_RS08220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLG_RS08230	COG1522	sequence-specific DNA binding
SLG_RS08235	COG2205	protein histidine kinase activity
SLG_RS08280	COG0776	regulation of translation
SLG_RS08300	COG2815	serine threonine protein kinase
SLG_RS08300	COG0515	serine threonine protein kinase
SLG_RS08315	COG2801	Transposase and inactivated derivatives
SLG_RS08315	COG3415	Transposase
SLG_RS08330	COG0574	Belongs to the PEP-utilizing enzyme family
SLG_RS08330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLG_RS08335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLG_RS08335	COG2111	Na H antiporter
SLG_RS08340	COG1006	Multisubunit Na H antiporter MnhC subunit
SLG_RS08345	COG0651	ATP synthesis coupled electron transport
SLG_RS08350	COG1863	multisubunit Na H antiporter MnhE subunit
SLG_RS08355	COG2212	antiporter activity
SLG_RS08400	COG2271	Major facilitator Superfamily
SLG_RS08405	COG1454	alcohol dehydrogenase
SLG_RS08410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLG_RS08415	COG0583	DNA-binding transcription factor activity
SLG_RS08450	COG0772	Belongs to the SEDS family
SLG_RS08475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SLG_RS08480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SLG_RS08485	COG3540	Alkaline phosphatase
SLG_RS08495	COG0012	GTP binding
SLG_RS08515	COG0193	aminoacyl-tRNA hydrolase activity
SLG_RS08520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SLG_RS08540	COG0752	glycyl-tRNA synthetase alpha subunit
SLG_RS08545	COG0751	glycine-tRNA ligase activity
SLG_RS08550	COG0574	Belongs to the PEP-utilizing enzyme family
SLG_RS08550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLG_RS08610	COG1468	defense response to virus
SLG_RS08615	COG1518	maintenance of DNA repeat elements
SLG_RS08620	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SLG_RS08640	COG3293	Transposase
SLG_RS08670	COG0582	viral genome integration into host DNA
SLG_RS08690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLG_RS08690	COG3153	acetyltransferase
SLG_RS08705	COG0686	Belongs to the AlaDH PNT family
SLG_RS08715	COG1051	belongs to the nudix hydrolase family
SLG_RS08730	COG0415	Belongs to the DNA photolyase family
SLG_RS08735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SLG_RS08740	COG1752	Esterase of the alpha-beta hydrolase superfamily
SLG_RS08775	COG2363	Small membrane protein
SLG_RS08780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SLG_RS08785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SLG_RS08795	COG4974	Belongs to the 'phage' integrase family
SLG_RS08800	COG0825	malonyl-CoA metabolic process
SLG_RS08820	COG0494	nUDIX hydrolase
SLG_RS08835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SLG_RS08840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLG_RS08860	COG3956	TIGRFAM MazG family protein
SLG_RS08865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SLG_RS08875	COG2204	response regulator
SLG_RS08880	COG5000	phosphorelay sensor kinase activity
SLG_RS08900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SLG_RS08900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SLG_RS08905	COG1546	Belongs to the CinA family
SLG_RS08905	COG1058	Belongs to the CinA family
SLG_RS08910	COG2867	negative regulation of translational initiation
SLG_RS08915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SLG_RS08920	COG0288	reversible hydration of carbon dioxide
SLG_RS08930	COG1254	Belongs to the acylphosphatase family
SLG_RS08935	COG0488	(ABC) transporter
SLG_RS08950	COG0531	amino acid
SLG_RS08965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SLG_RS08970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SLG_RS08990	COG0405	Gamma-glutamyltransferase
SLG_RS09010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLG_RS09020	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SLG_RS09025	COG4771	TonB-dependent receptor
SLG_RS09040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SLG_RS09095	COG3436	PFAM IS66 Orf2 family protein
SLG_RS09100	COG2433	Pfam Transposase IS66
SLG_RS09115	COG4771	TonB-dependent receptor
SLG_RS09120	COG0667	Aldo Keto reductase
SLG_RS09160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SLG_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS09215	COG2814	Major facilitator Superfamily
SLG_RS09220	COG2814	Major facilitator Superfamily
SLG_RS09225	COG2814	Major facilitator Superfamily
SLG_RS09255	COG0145	ligase activity
SLG_RS09260	COG4221	oxidoreductase activity
SLG_RS09270	COG2271	Major facilitator Superfamily
SLG_RS09280	COG4771	TonB-dependent receptor
SLG_RS09295	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SLG_RS09305	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SLG_RS09315	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS09330	COG2814	Major facilitator Superfamily
SLG_RS09345	COG4771	TonB-dependent receptor
SLG_RS09350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SLG_RS09355	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLG_RS09355	COG0022	dehydrogenase e1 component
SLG_RS09360	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLG_RS09365	COG2186	Transcriptional regulator
SLG_RS09380	COG2159	amidohydrolase
SLG_RS09385	COG3384	dioxygenase
SLG_RS09395	COG0473	3-isopropylmalate dehydrogenase activity
SLG_RS09395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SLG_RS09400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SLG_RS09400	COG0473	3-isopropylmalate dehydrogenase activity
SLG_RS09405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SLG_RS09565	COG5265	(ABC) transporter
SLG_RS09615	COG4957	zinc ion binding
SLG_RS09635	COG0464	growth
SLG_RS09655	COG3916	Acyl-homoserine-lactone synthase
SLG_RS09685	COG1595	DNA-templated transcription, initiation
SLG_RS09700	COG0823	Involved in the tonB-independent uptake of proteins
SLG_RS09700	COG1506	peptidase
SLG_RS09890	COG2814	Major facilitator Superfamily
SLG_RS09895	COG0583	DNA-binding transcription factor activity
SLG_RS09935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SLG_RS09940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SLG_RS09950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLG_RS09955	COG2124	cytochrome p450
SLG_RS09970	COG0321	lipoyl(octanoyl) transferase activity
SLG_RS09970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SLG_RS09975	COG0084	hydrolase, TatD family'
SLG_RS09995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLG_RS10000	COG1686	Belongs to the peptidase S11 family
SLG_RS10010	COG2951	lytic endotransglycosylase activity
SLG_RS10040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SLG_RS10045	COG1742	UPF0060 membrane protein
SLG_RS10050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SLG_RS10055	COG0156	8-amino-7-oxononanoate synthase activity
SLG_RS10060	COG2203	Gaf domain
SLG_RS10060	COG3706	GGDEF domain
SLG_RS10060	COG4251	negative regulation of phosphorylation
SLG_RS10060	COG5001	Diguanylate cyclase
SLG_RS10065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SLG_RS10070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SLG_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS10095	COG2814	Major facilitator Superfamily
SLG_RS10100	COG1309	transcriptional regulator
SLG_RS10110	COG0596	Alpha beta hydrolase
SLG_RS10110	COG2945	thiolester hydrolase activity
SLG_RS10115	COG2814	Major facilitator Superfamily
SLG_RS10120	COG0438	transferase activity, transferring glycosyl groups
SLG_RS10130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SLG_RS10135	COG0740	serine-type endopeptidase activity
SLG_RS10145	COG0544	peptidyl-prolyl cis-trans isomerase activity
SLG_RS10160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SLG_RS10165	COG0318	PFAM AMP-dependent synthetase and ligase
SLG_RS10170	COG0154	amidase activity
SLG_RS10175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SLG_RS10190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SLG_RS10200	COG0540	Belongs to the ATCase OTCase family
SLG_RS10205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLG_RS10230	COG0560	Phosphoserine phosphatase
SLG_RS10235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SLG_RS10245	COG0028	Belongs to the TPP enzyme family
SLG_RS10255	COG0440	acetolactate synthase activity
SLG_RS10260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SLG_RS10265	COG0438	transferase activity, transferring glycosyl groups
SLG_RS10270	COG2353	YceI-like domain
SLG_RS10285	COG0438	transferase activity, transferring glycosyl groups
SLG_RS10300	COG0463	Glycosyl transferase, family 2
SLG_RS10315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SLG_RS10320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SLG_RS10375	COG2205	protein histidine kinase activity
SLG_RS10405	COG2258	MOSC domain
SLG_RS10425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SLG_RS10430	COG0081	regulation of translation
SLG_RS10440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SLG_RS10445	COG0222	ribosome binding
SLG_RS10455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SLG_RS10500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SLG_RS10515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SLG_RS10520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SLG_RS10525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLG_RS10545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SLG_RS10550	COG0038	chloride channel
SLG_RS10555	COG0360	Binds together with S18 to 16S ribosomal RNA
SLG_RS10560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SLG_RS10565	COG0359	binds to the 23S rRNA
SLG_RS10580	COG0302	gtp cyclohydrolase
SLG_RS10585	COG0183	Belongs to the thiolase family
SLG_RS10590	COG1024	Enoyl-CoA hydratase
SLG_RS10590	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLG_RS10595	COG0297	glycogen (starch) synthase activity
SLG_RS10610	COG1695	Transcriptional regulator
SLG_RS10615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SLG_RS10635	COG0489	protein tyrosine kinase activity
SLG_RS10635	COG3206	protein involved in exopolysaccharide biosynthesis
SLG_RS10650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SLG_RS10680	COG0318	PFAM AMP-dependent synthetase and ligase
SLG_RS10845	COG3750	Belongs to the UPF0335 family
SLG_RS11085	COG0438	transferase activity, transferring glycosyl groups
SLG_RS11085	COG1216	Glycosyl transferase, family 2
SLG_RS11110	COG1218	3'(2'),5'-bisphosphate nucleotidase
SLG_RS11120	COG0175	sulfate reduction
SLG_RS11125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SLG_RS11125	COG1754	DNA topoisomerase type I activity
SLG_RS11130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLG_RS11130	COG0758	DNA mediated transformation
SLG_RS11135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SLG_RS11140	COG1506	peptidase
SLG_RS11140	COG0823	Involved in the tonB-independent uptake of proteins
SLG_RS11140	COG4946	Tricorn protease homolog
SLG_RS11150	COG5001	Diguanylate cyclase
SLG_RS11155	COG0318	PFAM AMP-dependent synthetase and ligase
SLG_RS11180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SLG_RS11200	COG0250	Participates in transcription elongation, termination and antitermination
SLG_RS11205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SLG_RS11210	COG2119	membrane
SLG_RS11215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SLG_RS11220	COG0352	thiamine-phosphate diphosphorylase activity
SLG_RS11220	COG0351	phosphomethylpyrimidine kinase
SLG_RS11225	COG3813	Protein conserved in bacteria
SLG_RS11230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SLG_RS11235	COG3104	oligopeptide transport
SLG_RS11245	COG2188	Transcriptional regulator
SLG_RS11250	COG2204	response regulator
SLG_RS11255	COG4251	negative regulation of phosphorylation
SLG_RS11260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SLG_RS11270	COG1322	Protein conserved in bacteria
SLG_RS11300	COG1136	(ABC) transporter
SLG_RS11310	COG0071	Belongs to the small heat shock protein (HSP20) family
SLG_RS11320	COG0504	CTP synthase activity
SLG_RS11335	COG0322	excinuclease ABC activity
SLG_RS11340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SLG_RS11345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SLG_RS11355	COG0356	it plays a direct role in the translocation of protons across the membrane
SLG_RS11380	COG2003	Belongs to the UPF0758 family
SLG_RS11390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SLG_RS11400	COG0284	orotidine-5'-phosphate decarboxylase activity
SLG_RS11415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SLG_RS11425	COG1007	ATP synthesis coupled electron transport
SLG_RS11440	COG0713	ATP synthesis coupled electron transport
SLG_RS11450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLG_RS11455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SLG_RS11460	COG1034	ATP synthesis coupled electron transport
SLG_RS11470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SLG_RS11475	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SLG_RS11485	COG0649	NAD binding
SLG_RS11490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLG_RS11495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLG_RS11500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLG_RS11515	COG0483	inositol monophosphate 1-phosphatase activity
SLG_RS11525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SLG_RS11540	COG0352	thiamine-phosphate diphosphorylase activity
SLG_RS11550	COG0386	Belongs to the glutathione peroxidase family
SLG_RS11555	COG3588	fructose-bisphosphate aldolase
SLG_RS11565	COG0126	phosphoglycerate kinase activity
SLG_RS11570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SLG_RS11610	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SLG_RS11625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SLG_RS11630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLG_RS11635	COG0552	protein localization to endoplasmic reticulum
SLG_RS11640	COG2917	probably involved in intracellular septation
SLG_RS11645	COG2329	Antibiotic biosynthesis monooxygenase
SLG_RS11650	COG0275	rRNA processing
SLG_RS11660	COG1758	RNA polymerase activity
SLG_RS11675	COG0037	tRNA processing
SLG_RS11700	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SLG_RS11705	COG1678	Uncharacterized ACR, COG1678
SLG_RS11710	COG0678	peroxiredoxin activity
SLG_RS11720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SLG_RS11745	COG2814	Major facilitator Superfamily
SLG_RS11760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SLG_RS11775	COG0789	Transcriptional regulator
SLG_RS11790	COG0335	large ribosomal subunit rRNA binding
SLG_RS11795	COG0336	Belongs to the RNA methyltransferase TrmD family
SLG_RS11815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SLG_RS11820	COG0228	four-way junction DNA binding
SLG_RS11825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SLG_RS11845	COG0477	Major facilitator Superfamily
SLG_RS11860	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SLG_RS11890	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLG_RS11890	COG0022	dehydrogenase e1 component
SLG_RS11895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SLG_RS11905	COG0148	phosphopyruvate hydratase activity
SLG_RS11940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SLG_RS11955	COG0505	Belongs to the CarA family
SLG_RS11960	COG1610	YqeY-like protein
SLG_RS11975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SLG_RS11980	COG0297	glycogen (starch) synthase activity
SLG_RS11990	COG2337	Toxic component of a toxin-antitoxin (TA) module
SLG_RS12000	COG3876	Protein conserved in bacteria
SLG_RS12010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SLG_RS12025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SLG_RS12035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SLG_RS12045	COG1346	cytolysis
SLG_RS12055	COG0514	ATP-dependent DNA helicase (RecQ)
SLG_RS12065	COG4106	trans-aconitate 2-methyltransferase activity
SLG_RS12075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SLG_RS12090	COG1748	Saccharopine dehydrogenase
SLG_RS12120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SLG_RS12125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SLG_RS12125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SLG_RS12135	COG0129	dihydroxy-acid dehydratase activity
SLG_RS12145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SLG_RS12150	COG0006	proline dipeptidase activity
SLG_RS12165	COG0741	lytic transglycosylase activity
SLG_RS12170	COG0521	Mo-molybdopterin cofactor biosynthetic process
SLG_RS12175	COG2885	chlorophyll binding
SLG_RS12180	COG0442	prolyl-tRNA aminoacylation
SLG_RS12185	COG4771	TonB-dependent receptor
SLG_RS12195	COG3243	poly(R)-hydroxyalkanoic acid synthase
SLG_RS12210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SLG_RS12215	COG0477	Major facilitator Superfamily
SLG_RS12220	COG4770	biotin carboxylase activity
SLG_RS12225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SLG_RS12235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLG_RS12235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLG_RS12240	COG1024	Enoyl-CoA hydratase
SLG_RS12245	COG0346	lactoylglutathione lyase activity
SLG_RS12250	COG0183	Belongs to the thiolase family
SLG_RS12255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SLG_RS12260	COG3800	Transcriptional regulator
SLG_RS12260	COG1396	sequence-specific DNA binding
SLG_RS12270	COG0166	Belongs to the GPI family
SLG_RS12275	COG0681	Belongs to the peptidase S26 family
SLG_RS12280	COG0571	ribonuclease III activity
SLG_RS12285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SLG_RS12295	COG3246	L-lysine catabolic process to acetate
SLG_RS12305	COG0475	glutathione-regulated potassium exporter activity
SLG_RS12305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SLG_RS12315	COG3243	poly(R)-hydroxyalkanoic acid synthase
SLG_RS12325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SLG_RS12330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SLG_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS12355	COG1063	alcohol dehydrogenase
SLG_RS12365	COG3246	L-lysine catabolic process to acetate
SLG_RS12385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SLG_RS12390	COG2267	carboxylic ester hydrolase activity
SLG_RS12400	COG1024	Enoyl-CoA hydratase
SLG_RS12425	COG3119	arylsulfatase activity
SLG_RS12480	COG2226	methyltransferase
SLG_RS12495	COG3781	membrane
SLG_RS12505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SLG_RS12510	COG2333	competence protein COMEC
SLG_RS12510	COG0658	competence protein
SLG_RS12515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SLG_RS12520	COG0372	Belongs to the citrate synthase family
SLG_RS12530	COG0242	peptide deformylase activity
SLG_RS12545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SLG_RS12550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SLG_RS12555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SLG_RS12560	COG0101	tRNA pseudouridine synthase activity
SLG_RS12570	COG0367	asparagine synthase
SLG_RS12580	COG0438	transferase activity, transferring glycosyl groups
SLG_RS12595	COG3409	Peptidoglycan-binding domain 1 protein
SLG_RS12595	COG3267	Type II secretory pathway component ExeA
SLG_RS12645	COG0492	ferredoxin-NADP+ reductase activity
SLG_RS12650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SLG_RS12660	COG1305	Transglutaminase-like
SLG_RS12670	COG2308	Evidence 4 Homologs of previously reported genes of
SLG_RS12675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLG_RS12680	COG1446	asparaginase
SLG_RS12700	COG1301	dicarboxylic acid transport
SLG_RS12705	COG0640	Transcriptional regulator
SLG_RS12725	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLG_RS12745	COG1448	Aminotransferase
SLG_RS12750	COG1522	sequence-specific DNA binding
SLG_RS12765	COG2967	ApaG domain
SLG_RS12780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SLG_RS12785	COG0473	3-isopropylmalate dehydrogenase activity
SLG_RS12790	COG1381	Involved in DNA repair and RecF pathway recombination
SLG_RS12795	COG0545	Peptidyl-prolyl cis-trans isomerase
SLG_RS12800	COG0149	triose-phosphate isomerase activity
SLG_RS12805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SLG_RS12810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SLG_RS12820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SLG_RS12825	COG0252	asparaginase activity
SLG_RS12840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SLG_RS12845	COG0134	indole-3-glycerol-phosphate synthase activity
SLG_RS12850	COG0315	cyclic pyranopterin monophosphate synthase activity
SLG_RS12855	COG0303	'Molybdopterin
SLG_RS12865	COG0582	viral genome integration into host DNA
SLG_RS12880	COG2948	multi-organism process
SLG_RS12895	COG3846	protein secretion by the type IV secretion system
SLG_RS12905	COG3451	type IV secretory pathway VirB4
SLG_RS12915	COG3838	Conjugal transfer protein Trbc
SLG_RS12920	COG4962	Type ii secretion system protein e
SLG_RS12960	COG0741	lytic transglycosylase activity
SLG_RS12975	COG5489	Protein of unknown function (DUF736)
SLG_RS12995	COG4227	nucleotidyltransferase activity
SLG_RS13015	COG3916	Acyl-homoserine-lactone synthase
SLG_RS13115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SLG_RS13125	COG2912	Transglutaminase-like superfamily
SLG_RS13155	COG0587	DNA-directed DNA polymerase activity
SLG_RS13160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLG_RS13215	COG3436	PFAM IS66 Orf2 family protein
SLG_RS13220	COG2433	Pfam Transposase IS66
SLG_RS13235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLG_RS13240	COG0459	protein refolding
SLG_RS13245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SLG_RS13255	COG5425	PFAM Usg family protein
SLG_RS13270	COG0071	Belongs to the small heat shock protein (HSP20) family
SLG_RS13275	COG0071	Belongs to the small heat shock protein (HSP20) family
SLG_RS13315	COG1595	DNA-templated transcription, initiation
SLG_RS13325	COG4771	TonB-dependent receptor
SLG_RS13330	COG0823	Involved in the tonB-independent uptake of proteins
SLG_RS13330	COG1506	peptidase
SLG_RS13335	COG0367	asparagine synthase
SLG_RS13390	COG0582	viral genome integration into host DNA
SLG_RS13395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLG_RS13400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SLG_RS13405	COG2080	2 iron, 2 sulfur cluster binding
SLG_RS13410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SLG_RS13420	COG0577	efflux transmembrane transporter activity
SLG_RS13425	COG1136	(ABC) transporter
SLG_RS13430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLG_RS13440	COG2204	response regulator
SLG_RS13460	COG2226	methyltransferase
SLG_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS13500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLG_RS13510	COG2814	Major facilitator Superfamily
SLG_RS13545	COG4774	siderophore transport
SLG_RS13545	COG1629	transport
SLG_RS13550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SLG_RS13595	COG0583	DNA-binding transcription factor activity
SLG_RS13605	COG0445	tRNA wobble uridine modification
SLG_RS13625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLG_RS13630	COG2207	Transcriptional regulator
SLG_RS13645	COG0702	epimerase
SLG_RS13685	COG2814	Major facilitator Superfamily
SLG_RS13705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SLG_RS13705	COG1648	precorrin-2 dehydrogenase activity
SLG_RS13710	COG0243	molybdopterin cofactor binding
SLG_RS13720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SLG_RS13730	COG2223	nitrite transmembrane transporter activity
SLG_RS13735	COG1116	anion transmembrane transporter activity
SLG_RS13735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SLG_RS13750	COG1802	Transcriptional regulator
SLG_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS13825	COG0300	oxidoreductase activity
SLG_RS13920	COG0179	Fumarylacetoacetate (FAA) hydrolase
SLG_RS13940	COG4774	siderophore transport
SLG_RS13960	COG3415	Transposase
SLG_RS13960	COG2801	Transposase and inactivated derivatives
SLG_RS13975	COG4221	oxidoreductase activity
SLG_RS14005	COG0297	glycogen (starch) synthase activity
SLG_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS14055	COG3665	Urea carboxylase-associated protein
SLG_RS14070	COG1294	oxidase, subunit
SLG_RS14075	COG1271	oxidase subunit
SLG_RS14080	COG1573	uracil-dna glycosylase
SLG_RS14125	COG1846	Transcriptional regulator
SLG_RS14155	COG0179	Fumarylacetoacetate (FAA) hydrolase
SLG_RS14160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLG_RS14170	COG4771	TonB-dependent receptor
SLG_RS14175	COG0702	epimerase
SLG_RS14185	COG2188	Transcriptional regulator
SLG_RS14190	COG2814	Major facilitator Superfamily
SLG_RS14215	COG2814	Major facilitator Superfamily
SLG_RS14355	COG0277	FAD linked oxidase domain protein
SLG_RS14370	COG0513	Belongs to the DEAD box helicase family
SLG_RS14385	COG0582	viral genome integration into host DNA
SLG_RS14395	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SLG_RS14445	COG0642	Histidine kinase
SLG_RS14450	COG0745	RESPONSE REGULATOR receiver
SLG_RS14460	COG3038	cytochrome b561
SLG_RS14475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SLG_RS14480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SLG_RS14485	COG0702	epimerase
SLG_RS14490	COG1968	undecaprenyl-diphosphatase activity
SLG_RS14530	COG3706	GGDEF domain
SLG_RS14540	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SLG_RS14545	COG1214	PFAM Peptidase M22, glycoprotease
SLG_RS14555	COG4957	zinc ion binding
SLG_RS14570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLG_RS14590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SLG_RS14595	COG1702	phosphate starvation-inducible protein PhoH
SLG_RS14600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SLG_RS14605	COG1253	flavin adenine dinucleotide binding
SLG_RS14625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SLG_RS14680	COG0047	phosphoribosylformylglycinamidine synthase activity
SLG_RS14685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLG_RS14690	COG0584	glycerophosphoryl diester phosphodiesterase
SLG_RS14715	COG0438	transferase activity, transferring glycosyl groups
SLG_RS14720	COG0698	ribose 5-phosphate isomerase
SLG_RS14725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SLG_RS14735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SLG_RS14750	COG0640	Transcriptional regulator
SLG_RS14760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SLG_RS14770	COG0823	Involved in the tonB-independent uptake of proteins
SLG_RS14770	COG1506	peptidase
SLG_RS14780	COG0517	IMP dehydrogenase activity
SLG_RS14780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SLG_RS14785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SLG_RS14805	COG0438	transferase activity, transferring glycosyl groups
SLG_RS14815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLG_RS14830	COG5002	protein histidine kinase activity
SLG_RS14845	COG0513	Belongs to the DEAD box helicase family
SLG_RS14850	COG1671	Belongs to the UPF0178 family
SLG_RS14865	COG3540	Alkaline phosphatase
SLG_RS14890	COG2080	2 iron, 2 sulfur cluster binding
SLG_RS14895	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SLG_RS14900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLG_RS14905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SLG_RS14920	COG0582	viral genome integration into host DNA
SLG_RS14975	COG1238	metal cluster binding
SLG_RS15000	COG2948	multi-organism process
SLG_RS15030	COG3451	type IV secretory pathway VirB4
SLG_RS15045	COG4962	Type ii secretion system protein e
SLG_RS15080	COG0741	lytic transglycosylase activity
SLG_RS15135	COG3609	addiction module antidote protein, CC2985 family
SLG_RS15155	COG3118	belongs to the thioredoxin family
SLG_RS15170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLG_RS15175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SLG_RS15180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLG_RS15200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SLG_RS15200	COG4106	trans-aconitate 2-methyltransferase activity
SLG_RS15210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLG_RS15230	COG1722	exodeoxyribonuclease VII activity
SLG_RS15240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SLG_RS15260	COG3590	peptidase
SLG_RS15270	COG0745	RESPONSE REGULATOR receiver
SLG_RS15290	COG0586	Pfam SNARE associated Golgi protein
SLG_RS15295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SLG_RS15310	COG4771	TonB-dependent receptor
SLG_RS15320	COG1278	Cold shock
SLG_RS15325	COG1301	dicarboxylic acid transport
SLG_RS15355	COG0745	RESPONSE REGULATOR receiver
SLG_RS15360	COG2205	protein histidine kinase activity
SLG_RS15365	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SLG_RS15370	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SLG_RS15375	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SLG_RS15410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SLG_RS15415	COG1113	amino acid transport
SLG_RS15420	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS15425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SLG_RS15455	COG4206	TonB-dependent receptor
SLG_RS15480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLG_RS15510	COG0583	DNA-binding transcription factor activity
SLG_RS15515	COG1301	dicarboxylic acid transport
SLG_RS15520	COG2814	Major facilitator Superfamily
SLG_RS15530	COG4771	TonB-dependent receptor
SLG_RS15560	COG1414	Transcriptional regulator
SLG_RS15565	COG0183	Belongs to the thiolase family
SLG_RS15570	COG1414	Transcriptional regulator
SLG_RS15575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SLG_RS15590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SLG_RS15605	COG0525	valine-tRNA ligase activity
SLG_RS15610	COG0534	Mate efflux family protein
SLG_RS15615	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS15620	COG0501	Belongs to the peptidase M48B family
SLG_RS15650	COG1215	transferase activity, transferring glycosyl groups
SLG_RS15655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SLG_RS15660	COG0799	negative regulation of ribosome biogenesis
SLG_RS15665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SLG_RS15675	COG0793	Belongs to the peptidase S41A family
SLG_RS15685	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SLG_RS15705	COG1228	amidohydrolase
SLG_RS15750	COG4771	TonB-dependent receptor
SLG_RS15755	COG0483	inositol monophosphate 1-phosphatase activity
SLG_RS15760	COG0312	modulator of DNA gyrase
SLG_RS15765	COG2816	NAD+ diphosphatase activity
SLG_RS15790	COG1196	nuclear chromosome segregation
SLG_RS15820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SLG_RS15835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SLG_RS15845	COG0045	succinate-CoA ligase (ADP-forming) activity
SLG_RS15850	COG2086	electron transfer activity
SLG_RS15865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SLG_RS15875	COG3609	addiction module antidote protein, CC2985 family
SLG_RS15890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SLG_RS15895	COG0129	dihydroxy-acid dehydratase activity
SLG_RS15900	COG0837	glucose binding
SLG_RS15905	COG0800	Aldolase
SLG_RS15925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLG_RS15930	COG0004	ammonium transporteR
SLG_RS15955	COG0438	transferase activity, transferring glycosyl groups
SLG_RS15960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLG_RS15965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SLG_RS15970	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS15985	COG1648	precorrin-2 dehydrogenase activity
SLG_RS15985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SLG_RS15995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SLG_RS16005	COG0175	sulfate reduction
SLG_RS16010	COG4106	trans-aconitate 2-methyltransferase activity
SLG_RS16015	COG2081	HI0933 family
SLG_RS16025	COG3791	Glutathione-dependent formaldehyde-activating
SLG_RS16030	COG0305	Participates in initiation and elongation during chromosome replication
SLG_RS16035	COG5328	Belongs to the UPF0262 family
SLG_RS16045	COG0295	cytidine deaminase activity
SLG_RS16055	COG0717	Belongs to the dCTP deaminase family
SLG_RS16060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SLG_RS16075	COG0564	pseudouridine synthase activity
SLG_RS16100	COG1956	GAF domain-containing protein
SLG_RS16110	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SLG_RS16120	COG4149	molybdate abc transporter
SLG_RS16125	COG0725	ABC transporter, periplasmic molybdate-binding protein
SLG_RS16135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SLG_RS16140	COG2084	Dehydrogenase
SLG_RS16145	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SLG_RS16150	COG1482	cell wall glycoprotein biosynthetic process
SLG_RS16170	COG0494	nUDIX hydrolase
SLG_RS16180	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SLG_RS16190	COG1970	mechanosensitive ion channel activity
SLG_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS16235	COG2321	neutral zinc metallopeptidase
SLG_RS16255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SLG_RS16260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SLG_RS16270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SLG_RS16275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLG_RS16285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SLG_RS16300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLG_RS16315	COG0009	L-threonylcarbamoyladenylate synthase
SLG_RS16340	COG0318	PFAM AMP-dependent synthetase and ligase
SLG_RS16355	COG0438	transferase activity, transferring glycosyl groups
SLG_RS16365	COG0625	glutathione transferase activity
SLG_RS16370	COG0604	alcohol dehydrogenase
SLG_RS16370	COG3321	synthase
SLG_RS16390	COG0625	glutathione transferase activity
SLG_RS16395	COG0670	Belongs to the BI1 family
SLG_RS16470	COG4695	Portal protein
SLG_RS16475	COG2197	response regulator
SLG_RS16490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SLG_RS16495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SLG_RS16500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SLG_RS16510	COG2207	Transcriptional regulator
SLG_RS16515	COG4221	oxidoreductase activity
SLG_RS16520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SLG_RS16540	COG0667	Aldo Keto reductase
SLG_RS16565	COG0137	argininosuccinate synthase activity
SLG_RS16580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SLG_RS16595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SLG_RS16620	COG2032	superoxide dismutase activity
SLG_RS16625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SLG_RS16640	COG3300	MHYT domain
SLG_RS16640	COG5001	Diguanylate cyclase
SLG_RS16650	COG1056	cytidyltransferase-related domain
SLG_RS16650	COG3172	ATPase kinase involved in NAD metabolism
SLG_RS16655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SLG_RS16670	COG0481	GTPase activity
SLG_RS16695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SLG_RS16720	COG1217	gtp-binding protein TYPA
SLG_RS16730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SLG_RS16730	COG4651	solute:proton antiporter activity
SLG_RS16785	COG0590	tRNA wobble adenosine to inosine editing
SLG_RS16790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SLG_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS16810	COG3279	Response regulator of the LytR AlgR family
SLG_RS16815	COG3275	phosphorelay sensor kinase activity
SLG_RS16820	COG1733	regulation of RNA biosynthetic process
SLG_RS16845	COG1329	Transcriptional regulator
SLG_RS16850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SLG_RS16865	COG0739	heme binding
SLG_RS16875	COG4771	TonB-dependent receptor
SLG_RS16945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SLG_RS16985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SLG_RS16990	COG0408	coproporphyrinogen oxidase activity
SLG_RS17000	COG0321	lipoyl(octanoyl) transferase activity
SLG_RS17010	COG0602	queuosine metabolic process
SLG_RS17015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SLG_RS17030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SLG_RS17035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SLG_RS17055	COG1131	(ABC) transporter
SLG_RS17070	COG0546	phosphoglycolate phosphatase activity
SLG_RS17080	COG0435	Glutathione S-transferase
SLG_RS17090	COG1477	protein flavinylation
SLG_RS17115	COG4774	siderophore transport
SLG_RS17120	COG3128	pkhd-type hydroxylase
SLG_RS17155	COG1538	Outer membrane efflux protein
SLG_RS17170	COG1136	(ABC) transporter
SLG_RS17170	COG0577	efflux transmembrane transporter activity
SLG_RS17175	COG0577	efflux transmembrane transporter activity
SLG_RS17175	COG1136	(ABC) transporter
SLG_RS17195	COG5039	Polysaccharide pyruvyl transferase
SLG_RS17200	COG0110	maltose O-acetyltransferase activity
SLG_RS17205	COG0058	SHG alpha-glucan phosphorylase activity
SLG_RS17215	COG1063	alcohol dehydrogenase
SLG_RS17235	COG0247	lactate metabolic process
SLG_RS17240	COG0277	FAD linked oxidase domain protein
SLG_RS17245	COG0277	FAD linked oxidase domain protein
SLG_RS17250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SLG_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS17320	COG4638	Rieske (2fe-2S)
SLG_RS17330	COG4771	TonB-dependent receptor
SLG_RS17345	COG1024	Enoyl-CoA hydratase
SLG_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS17390	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SLG_RS17400	COG0424	maF-like protein
SLG_RS17405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SLG_RS17410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SLG_RS17415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SLG_RS17420	COG0156	8-amino-7-oxononanoate synthase activity
SLG_RS17425	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SLG_RS17430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SLG_RS17435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLG_RS17440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SLG_RS17445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SLG_RS17455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SLG_RS17470	COG0482	sulfurtransferase activity
SLG_RS17485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLG_RS17500	COG1988	membrane-bound metal-dependent
SLG_RS17510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SLG_RS17510	COG0519	Catalyzes the synthesis of GMP from XMP
SLG_RS17520	COG1505	serine-type exopeptidase activity
SLG_RS17525	COG0203	ribosomal protein L17
SLG_RS17530	COG0202	RNA polymerase activity
SLG_RS17535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SLG_RS17540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SLG_RS17555	COG0563	adenylate kinase activity
SLG_RS17560	COG0201	protein transport
SLG_RS17565	COG0200	Binds to the 23S rRNA
SLG_RS17575	COG1841	ribosomal large subunit assembly
SLG_RS17580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SLG_RS17585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SLG_RS17590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SLG_RS17595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SLG_RS17600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SLG_RS17605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SLG_RS17610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SLG_RS17615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SLG_RS17620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SLG_RS17625	COG0255	Belongs to the universal ribosomal protein uL29 family
SLG_RS17630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SLG_RS17635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SLG_RS17640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SLG_RS17645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SLG_RS17650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SLG_RS17655	COG0089	rRNA binding
SLG_RS17660	COG0088	Forms part of the polypeptide exit tunnel
SLG_RS17665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SLG_RS17670	COG0051	transcription antitermination factor activity, RNA binding
SLG_RS17675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SLG_RS17680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SLG_RS17685	COG0049	tRNA binding
SLG_RS17690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SLG_RS17700	COG2226	methyltransferase
SLG_RS17705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SLG_RS17710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SLG_RS17715	COG0756	dUTP diphosphatase activity
SLG_RS17725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SLG_RS17750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SLG_RS17755	COG2267	carboxylic ester hydrolase activity
SLG_RS17760	COG1741	Belongs to the pirin family
SLG_RS17780	COG4771	TonB-dependent receptor
SLG_RS17810	COG2833	Protein of unknown function (DUF455)
SLG_RS17820	COG0316	Belongs to the HesB IscA family
SLG_RS17840	COG1733	regulation of RNA biosynthetic process
SLG_RS17845	COG5507	3-demethylubiquinone-9 3-methyltransferase
SLG_RS17905	COG1842	Phage shock protein A
SLG_RS17910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SLG_RS17915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SLG_RS17925	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLG_RS17930	COG1607	acyl-coa hydrolase
SLG_RS17935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLG_RS17940	COG0671	phosphoesterase, PA-phosphatase related
SLG_RS17945	COG1228	amidohydrolase
SLG_RS17960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLG_RS17965	COG0354	folic acid binding
SLG_RS17985	COG1530	ribonuclease E activity
SLG_RS17995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SLG_RS18000	COG3706	GGDEF domain
SLG_RS18060	COG0438	transferase activity, transferring glycosyl groups
SLG_RS18075	COG0730	response to heat
SLG_RS18120	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SLG_RS18135	COG2890	protein-(glutamine-N5) methyltransferase activity
SLG_RS18140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SLG_RS18145	COG0124	histidyl-tRNA synthetase
SLG_RS18165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SLG_RS18175	COG0129	dihydroxy-acid dehydratase activity
SLG_RS18180	COG0667	Aldo Keto reductase
SLG_RS18205	COG4774	siderophore transport
SLG_RS18235	COG1404	Belongs to the peptidase S8 family
SLG_RS18240	COG0629	single-stranded DNA binding
SLG_RS18260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SLG_RS18270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLG_RS18270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLG_RS18285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SLG_RS18285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SLG_RS18300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SLG_RS18310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SLG_RS18335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLG_RS18345	COG2244	polysaccharide biosynthetic process
SLG_RS18400	COG0494	nUDIX hydrolase
SLG_RS18405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SLG_RS18415	COG0586	Pfam SNARE associated Golgi protein
SLG_RS18420	COG0189	ligase activity
SLG_RS18425	COG0792	nuclease activity
SLG_RS18430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SLG_RS18440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SLG_RS18460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SLG_RS18460	COG2169	Transcriptional regulator
SLG_RS18475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SLG_RS18480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SLG_RS18485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SLG_RS18490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SLG_RS18495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SLG_RS18505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SLG_RS18595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SLG_RS18605	COG1999	signal sequence binding
SLG_RS18610	COG2983	Belongs to the UPF0260 family
SLG_RS18625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLG_RS18635	COG2346	COG2346, Truncated hemoglobins
SLG_RS18650	COG0495	leucyl-tRNA aminoacylation
SLG_RS18665	COG0352	thiamine-phosphate diphosphorylase activity
SLG_RS18670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SLG_RS18675	COG4771	TonB-dependent receptor
SLG_RS18685	COG1054	Belongs to the UPF0176 family
SLG_RS18695	COG1201	RNA secondary structure unwinding
SLG_RS18715	COG1192	Involved in chromosome partitioning
SLG_RS18720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SLG_RS18750	COG0784	Response regulator, receiver
SLG_RS18755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SLG_RS18770	COG0783	Belongs to the Dps family
SLG_RS18775	COG1278	Cold shock
SLG_RS18795	COG1137	ATPase activity
SLG_RS18800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SLG_RS18810	COG5487	UPF0391 membrane protein
SLG_RS18835	COG2814	Major facilitator Superfamily
SLG_RS18855	COG0300	oxidoreductase activity
SLG_RS18875	COG1609	Transcriptional regulator
SLG_RS18880	COG1012	belongs to the aldehyde dehydrogenase family
SLG_RS18905	COG0280	phosphate acetyltransferase
SLG_RS18905	COG0281	malic enzyme
SLG_RS18910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SLG_RS18915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SLG_RS18925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SLG_RS18930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SLG_RS18935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SLG_RS18940	COG0072	phenylalanine-tRNA ligase activity
SLG_RS18955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SLG_RS18965	COG4942	peptidase
SLG_RS18980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SLG_RS18985	COG3047	cAMP biosynthetic process
SLG_RS19010	COG2010	Cytochrome c
SLG_RS19030	COG4191	Histidine kinase
SLG_RS19060	COG0312	modulator of DNA gyrase
SLG_RS19070	COG2989	Protein conserved in bacteria
SLG_RS19085	COG0488	(ABC) transporter
SLG_RS19090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SLG_RS19095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SLG_RS19105	COG1612	heme a metabolic process
SLG_RS19120	COG0316	Belongs to the HesB IscA family
SLG_RS19125	COG2151	metal-sulfur cluster biosynthetic enzyme
SLG_RS19135	COG0719	Fe-S assembly protein
SLG_RS19145	COG0396	ATPase activity
SLG_RS19155	COG0719	Fe-S assembly protein
SLG_RS19175	COG0167	dihydroorotate dehydrogenase activity
SLG_RS19180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SLG_RS19190	COG1028	Short-chain dehydrogenase reductase Sdr
SLG_RS19195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SLG_RS19200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLG_RS19200	COG2010	Cytochrome c
SLG_RS19205	COG0489	protein tyrosine kinase activity
SLG_RS19210	COG0330	HflC and HflK could
SLG_RS19225	COG0433	COG0433 Predicted ATPase
SLG_RS19230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SLG_RS19235	COG2897	thiosulfate sulfurtransferase activity
SLG_RS19240	COG0626	cystathionine gamma-synthase activity
SLG_RS19250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SLG_RS19260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SLG_RS19280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SLG_RS19285	COG1127	ABC transporter
SLG_RS19300	COG0308	aminopeptidase N
SLG_RS19320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SLG_RS19340	COG0357	Ribosomal RNA small subunit methyltransferase G
SLG_RS19345	COG0445	tRNA wobble uridine modification
SLG_RS19350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SLG_RS19360	COG0861	Integral membrane protein TerC family
SLG_RS19365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SLG_RS19370	COG0778	Nitroreductase
SLG_RS19380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SLG_RS19555	COG0632	four-way junction helicase activity
SLG_RS19600	COG0728	peptidoglycan biosynthetic process
SLG_RS19605	COG0728	peptidoglycan biosynthetic process
SLG_RS19710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SLG_RS20070	COG0628	permease
SLG_RS20090	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SLG_RS20180	COG2010	Cytochrome c
SLG_RS20240	COG2311	Membrane
SLG_RS20250	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLG_RS20255	COG1216	Glycosyl transferase, family 2
SLG_RS20255	COG1442	glycosyl transferase family 8
SLG_RS20270	COG4191	Histidine kinase
SLG_RS20275	COG2200	EAL domain
SLG_RS20300	COG0425	Belongs to the sulfur carrier protein TusA family
SLG_RS20325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SLG_RS20325	COG2755	lipolytic protein G-D-S-L family
SLG_RS20385	COG3300	MHYT domain
SLG_RS20385	COG5001	Diguanylate cyclase
SLG_RS20500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLG_RS20505	COG0438	transferase activity, transferring glycosyl groups
SLG_RS20610	COG0739	heme binding
SLG_RS20610	COG0741	lytic transglycosylase activity
SLG_RS20610	COG1196	nuclear chromosome segregation
SLG_RS20615	COG1216	Glycosyl transferase, family 2
SLG_RS20620	COG1215	transferase activity, transferring glycosyl groups