locus-tag	class	description
A6768_RS00010	COG5001	Diguanylate cyclase
A6768_RS00010	COG3300	MHYT domain
A6768_RS00030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6768_RS00035	COG0728	peptidoglycan biosynthetic process
A6768_RS00040	COG0180	Tryptophanyl-tRNA synthetase
A6768_RS00050	COG1301	dicarboxylic acid transport
A6768_RS00055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6768_RS00065	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6768_RS00075	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6768_RS00100	COG0318	PFAM AMP-dependent synthetase and ligase
A6768_RS00105	COG5001	Diguanylate cyclase
A6768_RS00110	COG1192	Involved in chromosome partitioning
A6768_RS00120	COG0439	Biotin carboxylase
A6768_RS00125	COG0511	ligase activity, forming carbon-carbon bonds
A6768_RS00135	COG2022	thiamine diphosphate biosynthetic process
A6768_RS00165	COG0537	adenosine 5'-monophosphoramidase activity
A6768_RS00190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6768_RS00235	COG0662	Cupin 2, conserved barrel domain protein
A6768_RS00235	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6768_RS00255	COG1482	cell wall glycoprotein biosynthetic process
A6768_RS00265	COG4149	molybdate abc transporter
A6768_RS00275	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6768_RS00280	COG0243	molybdopterin cofactor binding
A6768_RS00330	COG0643	Histidine kinase
A6768_RS00330	COG0784	Response regulator, receiver
A6768_RS00330	COG2198	Histidine kinase
A6768_RS00340	COG0745	RESPONSE REGULATOR receiver
A6768_RS00345	COG2201	protein-glutamate methylesterase activity
A6768_RS00350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6768_RS00355	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6768_RS00385	COG0840	transmembrane signaling receptor activity
A6768_RS00400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6768_RS00405	COG2917	probably involved in intracellular septation
A6768_RS00410	COG0552	protein localization to endoplasmic reticulum
A6768_RS00415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6768_RS00420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6768_RS00430	COG4206	TonB-dependent receptor
A6768_RS00435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6768_RS00440	COG1120	ATPase activity
A6768_RS00450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6768_RS00455	COG0792	nuclease activity
A6768_RS00460	COG0189	ligase activity
A6768_RS00465	COG0586	Pfam SNARE associated Golgi protein
A6768_RS00495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6768_RS00500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6768_RS00505	COG1505	serine-type exopeptidase activity
A6768_RS00525	COG4166	transmembrane transport
A6768_RS00540	COG0222	ribosome binding
A6768_RS00545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6768_RS00550	COG3657	addiction module killer protein
A6768_RS00555	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6768_RS00570	COG3275	phosphorelay sensor kinase activity
A6768_RS00575	COG3279	Response regulator of the LytR AlgR family
A6768_RS00580	COG4221	oxidoreductase activity
A6768_RS00585	COG2207	Transcriptional regulator
A6768_RS00600	COG0590	tRNA wobble adenosine to inosine editing
A6768_RS00610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6768_RS00685	COG2853	Lipoprotein
A6768_RS00705	COG0582	viral genome integration into host DNA
A6768_RS00735	COG4251	negative regulation of phosphorylation
A6768_RS00760	COG0745	RESPONSE REGULATOR receiver
A6768_RS00765	COG5002	protein histidine kinase activity
A6768_RS00775	COG0071	Belongs to the small heat shock protein (HSP20) family
A6768_RS00785	COG0459	protein refolding
A6768_RS00790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6768_RS00800	COG5425	PFAM Usg family protein
A6768_RS00810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6768_RS00815	COG0583	DNA-binding transcription factor activity
A6768_RS00820	COG2271	Major facilitator Superfamily
A6768_RS00850	COG0798	PFAM Bile acid sodium symporter
A6768_RS00940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6768_RS00965	COG0693	protein deglycase activity
A6768_RS00975	COG0784	Response regulator, receiver
A6768_RS00975	COG4191	Histidine kinase
A6768_RS01030	COG3634	alkyl hydroperoxide reductase activity
A6768_RS01040	COG1309	transcriptional regulator
A6768_RS01055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6768_RS01060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6768_RS01070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6768_RS01075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6768_RS01085	COG0105	UTP biosynthetic process
A6768_RS01120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6768_RS01135	COG1506	peptidase
A6768_RS01135	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS01150	COG0525	valine-tRNA ligase activity
A6768_RS01155	COG0534	Mate efflux family protein
A6768_RS01170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6768_RS01185	COG1160	GTP binding
A6768_RS01200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6768_RS01205	COG4774	siderophore transport
A6768_RS01225	COG1764	response to oxidative stress
A6768_RS01230	COG0697	spore germination
A6768_RS01250	COG0438	transferase activity, transferring glycosyl groups
A6768_RS01275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6768_RS01280	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6768_RS01285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6768_RS01295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6768_RS01300	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6768_RS01310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6768_RS01310	COG2169	Transcriptional regulator
A6768_RS01335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6768_RS01360	COG3447	MASE1 domain protein
A6768_RS01360	COG5002	protein histidine kinase activity
A6768_RS01360	COG3447	MASE1 domain protein
A6768_RS01360	COG5001	Diguanylate cyclase
A6768_RS01360	COG5002	protein histidine kinase activity
A6768_RS01360	COG5001	Diguanylate cyclase
A6768_RS01365	COG0101	tRNA pseudouridine synthase activity
A6768_RS01370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6768_RS01375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6768_RS01385	COG4638	Rieske (2fe-2S)
A6768_RS01390	COG1309	transcriptional regulator
A6768_RS01395	COG0242	peptide deformylase activity
A6768_RS01405	COG0443	Heat shock 70 kDa protein
A6768_RS01410	COG0745	RESPONSE REGULATOR receiver
A6768_RS01415	COG0704	Plays a role in the regulation of phosphate uptake
A6768_RS01420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6768_RS01425	COG0581	inorganic phosphate transmembrane transporter activity
A6768_RS01430	COG0573	inorganic phosphate transmembrane transporter activity
A6768_RS01460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6768_RS01470	COG1309	transcriptional regulator
A6768_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS01495	COG3609	addiction module antidote protein, CC2985 family
A6768_RS01545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6768_RS01550	COG0066	3-isopropylmalate dehydratase activity
A6768_RS01565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6768_RS01600	COG3682	Transcriptional regulator
A6768_RS01610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6768_RS01630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6768_RS01635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6768_RS01655	COG1420	regulation of RNA biosynthetic process
A6768_RS01660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6768_RS01695	COG4771	TonB-dependent receptor
A6768_RS01745	COG1132	(ABC) transporter
A6768_RS01755	COG2186	Transcriptional regulator
A6768_RS01775	COG0129	dihydroxy-acid dehydratase activity
A6768_RS01780	COG3734	2-keto-3-deoxy-galactonokinase
A6768_RS01785	COG0800	Aldolase
A6768_RS01790	COG4191	Histidine kinase
A6768_RS01790	COG0784	Response regulator, receiver
A6768_RS01795	COG1612	heme a metabolic process
A6768_RS01800	COG1324	tolerance protein
A6768_RS01810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6768_RS01815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6768_RS01825	COG3237	CsbD-like
A6768_RS01830	COG1115	amino acid carrier protein
A6768_RS01835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6768_RS01840	COG3813	Protein conserved in bacteria
A6768_RS01845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6768_RS01845	COG0352	thiamine-phosphate diphosphorylase activity
A6768_RS01845	COG0351	phosphomethylpyrimidine kinase
A6768_RS01850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6768_RS01860	COG0531	amino acid
A6768_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS01890	COG2321	neutral zinc metallopeptidase
A6768_RS01905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6768_RS01910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6768_RS01915	COG2833	Protein of unknown function (DUF455)
A6768_RS01920	COG4942	peptidase
A6768_RS01925	COG0316	Belongs to the HesB IscA family
A6768_RS01950	COG3781	membrane
A6768_RS01960	COG0583	DNA-binding transcription factor activity
A6768_RS01965	COG4771	TonB-dependent receptor
A6768_RS01975	COG0456	acetyltransferase
A6768_RS02015	COG3386	PFAM SMP-30 Gluconolaconase
A6768_RS02020	COG0673	inositol 2-dehydrogenase activity
A6768_RS02035	COG2186	Transcriptional regulator
A6768_RS02040	COG1597	lipid kinase activity
A6768_RS02045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6768_RS02050	COG3706	GGDEF domain
A6768_RS02050	COG5001	Diguanylate cyclase
A6768_RS02050	COG2203	Gaf domain
A6768_RS02050	COG4251	negative regulation of phosphorylation
A6768_RS02055	COG0583	DNA-binding transcription factor activity
A6768_RS02065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6768_RS02070	COG2226	methyltransferase
A6768_RS02080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6768_RS02085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6768_RS02100	COG4771	TonB-dependent receptor
A6768_RS02185	COG0659	secondary active sulfate transmembrane transporter activity
A6768_RS02200	COG2205	protein histidine kinase activity
A6768_RS02205	COG1045	serine acetyltransferase
A6768_RS02225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6768_RS02230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6768_RS02235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6768_RS02240	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6768_RS02260	COG0252	asparaginase activity
A6768_RS02270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6768_RS02275	COG1329	Transcriptional regulator
A6768_RS02280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6768_RS02290	COG1253	flavin adenine dinucleotide binding
A6768_RS02295	COG0572	uridine kinase
A6768_RS02305	COG0077	Prephenate dehydratase
A6768_RS02305	COG1605	Chorismate mutase
A6768_RS02310	COG3119	arylsulfatase activity
A6768_RS02330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6768_RS02335	COG2835	tetraacyldisaccharide 4'-kinase activity
A6768_RS02340	COG0248	Ppx GppA phosphatase
A6768_RS02345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6768_RS02360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6768_RS02365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6768_RS02385	COG0739	heme binding
A6768_RS02405	COG1213	nucleotidyl transferase
A6768_RS02435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6768_RS02445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6768_RS02450	COG0039	L-malate dehydrogenase activity
A6768_RS02455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6768_RS02460	COG0567	Dehydrogenase, E1 component
A6768_RS02465	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6768_RS02470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6768_RS02490	COG0546	phosphoglycolate phosphatase activity
A6768_RS02495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6768_RS02500	COG1408	metallophosphoesterase
A6768_RS02505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6768_RS02510	COG3153	acetyltransferase
A6768_RS02510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6768_RS02515	COG0538	isocitrate dehydrogenase activity
A6768_RS02520	COG0688	phosphatidylethanolamine metabolic process
A6768_RS02525	COG1183	phosphatidylcholine synthase activity
A6768_RS02535	COG0052	Belongs to the universal ribosomal protein uS2 family
A6768_RS02540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6768_RS02545	COG0528	UMP kinase activity
A6768_RS02550	COG0233	cytoplasmic translational termination
A6768_RS02555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6768_RS02565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6768_RS02570	COG0750	zinc metalloprotease
A6768_RS02575	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6768_RS02585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6768_RS02590	COG0254	rRNA binding
A6768_RS02595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6768_RS02600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6768_RS02615	COG4974	Belongs to the 'phage' integrase family
A6768_RS02620	COG0825	malonyl-CoA metabolic process
A6768_RS02640	COG0494	nUDIX hydrolase
A6768_RS02655	COG2311	Membrane
A6768_RS02660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6768_RS02660	COG4106	trans-aconitate 2-methyltransferase activity
A6768_RS02665	COG3507	Belongs to the glycosyl hydrolase 43 family
A6768_RS02675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6768_RS02690	COG1722	exodeoxyribonuclease VII activity
A6768_RS02695	COG0142	geranyltranstransferase activity
A6768_RS02700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6768_RS02710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6768_RS02725	COG0583	DNA-binding transcription factor activity
A6768_RS02730	COG1960	acyl-CoA dehydrogenase activity
A6768_RS02740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6768_RS02755	COG2030	dehydratase
A6768_RS02760	COG2301	Belongs to the HpcH HpaI aldolase family
A6768_RS02775	COG0667	Aldo Keto reductase
A6768_RS02785	COG3022	response to hydroperoxide
A6768_RS02790	COG2819	hydrolase of the alpha beta superfamily
A6768_RS02800	COG0300	oxidoreductase activity
A6768_RS02830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6768_RS02840	COG0149	triose-phosphate isomerase activity
A6768_RS02850	COG0504	CTP synthase activity
A6768_RS02855	COG1902	pentaerythritol trinitrate reductase activity
A6768_RS02875	COG2133	pyrroloquinoline quinone binding
A6768_RS02890	COG0779	Required for maturation of 30S ribosomal subunits
A6768_RS02900	COG1942	4-Oxalocrotonate Tautomerase
A6768_RS02910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6768_RS02925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6768_RS02940	COG1435	thymidine kinase activity
A6768_RS02955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6768_RS02960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6768_RS02965	COG1185	polyribonucleotide nucleotidyltransferase activity
A6768_RS02975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6768_RS02995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6768_RS03015	COG2910	NAD(P)H-binding
A6768_RS03020	COG0625	glutathione transferase activity
A6768_RS03025	COG0589	response to stress
A6768_RS03030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6768_RS03035	COG0459	protein refolding
A6768_RS03040	COG3300	MHYT domain
A6768_RS03040	COG5001	Diguanylate cyclase
A6768_RS03045	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6768_RS03045	COG1024	Enoyl-CoA hydratase
A6768_RS03055	COG0343	queuine tRNA-ribosyltransferase activity
A6768_RS03070	COG0784	Response regulator, receiver
A6768_RS03085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6768_RS03090	COG4191	Histidine kinase
A6768_RS03095	COG2204	response regulator
A6768_RS03105	COG2188	Transcriptional regulator
A6768_RS03110	COG0778	Nitroreductase
A6768_RS03115	COG3104	oligopeptide transport
A6768_RS03140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6768_RS03145	COG5487	UPF0391 membrane protein
A6768_RS03160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6768_RS03175	COG0670	Belongs to the BI1 family
A6768_RS03185	COG1506	peptidase
A6768_RS03185	COG4946	Tricorn protease homolog
A6768_RS03185	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS03235	COG0318	PFAM AMP-dependent synthetase and ligase
A6768_RS03240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6768_RS03250	COG0009	L-threonylcarbamoyladenylate synthase
A6768_RS03290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6768_RS03305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6768_RS03310	COG4206	TonB-dependent receptor
A6768_RS03315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6768_RS03325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6768_RS03330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6768_RS03370	COG0729	surface antigen
A6768_RS03380	COG1760	l-serine dehydratase
A6768_RS03400	COG0284	orotidine-5'-phosphate decarboxylase activity
A6768_RS03415	COG0477	Major facilitator Superfamily
A6768_RS03445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6768_RS03460	COG0583	DNA-binding transcription factor activity
A6768_RS03475	COG3661	Belongs to the glycosyl hydrolase 67 family
A6768_RS03480	COG1472	Belongs to the glycosyl hydrolase 3 family
A6768_RS03485	COG1472	Belongs to the glycosyl hydrolase 3 family
A6768_RS03490	COG4948	Mandelate Racemase Muconate Lactonizing
A6768_RS03495	COG2271	Major facilitator Superfamily
A6768_RS03500	COG0246	Mannitol dehydrogenase
A6768_RS03505	COG3250	beta-galactosidase activity
A6768_RS03525	COG1522	sequence-specific DNA binding
A6768_RS03535	COG1764	response to oxidative stress
A6768_RS03540	COG1846	Transcriptional regulator
A6768_RS03555	COG3437	response regulator, receiver
A6768_RS03555	COG3850	Histidine kinase
A6768_RS03555	COG4999	Histidine kinase
A6768_RS03555	COG2205	protein histidine kinase activity
A6768_RS03560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6768_RS03565	COG2202	Pas domain
A6768_RS03565	COG3920	Histidine kinase
A6768_RS03580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6768_RS03605	COG0628	permease
A6768_RS03630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6768_RS03650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6768_RS03655	COG0126	phosphoglycerate kinase activity
A6768_RS03660	COG2814	Major facilitator Superfamily
A6768_RS03665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6768_RS03670	COG3588	fructose-bisphosphate aldolase
A6768_RS03680	COG0352	thiamine-phosphate diphosphorylase activity
A6768_RS03690	COG1376	ErfK ybiS ycfS ynhG family protein
A6768_RS03695	COG4942	peptidase
A6768_RS03700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6768_RS03710	COG0483	inositol monophosphate 1-phosphatase activity
A6768_RS03715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6768_RS03720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6768_RS03725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6768_RS03730	COG0649	NAD binding
A6768_RS03735	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6768_RS03740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6768_RS03750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6768_RS03755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6768_RS03765	COG0713	ATP synthesis coupled electron transport
A6768_RS03780	COG1007	ATP synthesis coupled electron transport
A6768_RS03790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6768_RS03825	COG3739	integral membrane protein
A6768_RS03840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6768_RS03850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6768_RS03855	COG0358	DNA primase activity
A6768_RS03860	COG2852	Protein conserved in bacteria
A6768_RS03865	COG1610	YqeY-like protein
A6768_RS03870	COG0505	Belongs to the CarA family
A6768_RS03885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6768_RS03920	COG0148	phosphopyruvate hydratase activity
A6768_RS03930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6768_RS03935	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6768_RS03935	COG0022	dehydrogenase e1 component
A6768_RS03965	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6768_RS03995	COG0251	oxidation-reduction process
A6768_RS04015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6768_RS04020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6768_RS04030	COG2353	YceI-like domain
A6768_RS04035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6768_RS04040	COG0440	acetolactate synthase activity
A6768_RS04050	COG0028	Belongs to the TPP enzyme family
A6768_RS04055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6768_RS04060	COG0560	Phosphoserine phosphatase
A6768_RS04060	COG3830	Belongs to the UPF0237 family
A6768_RS04080	COG0789	Transcriptional regulator
A6768_RS04090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6768_RS04100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6768_RS04105	COG0154	amidase activity
A6768_RS04110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6768_RS04150	COG0058	SHG alpha-glucan phosphorylase activity
A6768_RS04155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6768_RS04160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6768_RS04165	COG0297	glycogen (starch) synthase activity
A6768_RS04170	COG1523	belongs to the glycosyl hydrolase 13 family
A6768_RS04190	COG0673	inositol 2-dehydrogenase activity
A6768_RS04210	COG3250	beta-galactosidase activity
A6768_RS04215	COG3401	FG-GAP repeat protein
A6768_RS04235	COG1573	uracil-dna glycosylase
A6768_RS04240	COG1742	UPF0060 membrane protein
A6768_RS04275	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS04275	COG1506	peptidase
A6768_RS04275	COG4946	Tricorn protease homolog
A6768_RS04280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6768_RS04290	COG2827	Endonuclease containing a URI domain
A6768_RS04295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6768_RS04300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6768_RS04305	COG0698	ribose 5-phosphate isomerase
A6768_RS04315	COG0071	Belongs to the small heat shock protein (HSP20) family
A6768_RS04325	COG1136	(ABC) transporter
A6768_RS04350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6768_RS04350	COG3153	acetyltransferase
A6768_RS04380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6768_RS04405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6768_RS04410	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6768_RS04435	COG0113	porphobilinogen synthase activity
A6768_RS04440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6768_RS04465	COG0800	Aldolase
A6768_RS04470	COG0837	glucose binding
A6768_RS04475	COG0129	dihydroxy-acid dehydratase activity
A6768_RS04480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6768_RS04500	COG0640	Transcriptional regulator
A6768_RS04515	COG0436	Aminotransferase
A6768_RS04525	COG0363	glucosamine-6-phosphate deaminase activity
A6768_RS04530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6768_RS04540	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6768_RS04540	COG1024	Enoyl-CoA hydratase
A6768_RS04545	COG0183	Belongs to the thiolase family
A6768_RS04555	COG2814	Major facilitator Superfamily
A6768_RS04590	COG2226	methyltransferase
A6768_RS04600	COG1131	(ABC) transporter
A6768_RS04605	COG0842	Transport permease protein
A6768_RS04615	COG0534	Mate efflux family protein
A6768_RS04620	COG2354	Protein conserved in bacteria
A6768_RS04640	COG0359	binds to the 23S rRNA
A6768_RS04645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6768_RS04650	COG0360	Binds together with S18 to 16S ribosomal RNA
A6768_RS04655	COG2610	gluconate transmembrane transporter activity
A6768_RS04675	COG0577	efflux transmembrane transporter activity
A6768_RS04675	COG1136	(ABC) transporter
A6768_RS04680	COG0577	efflux transmembrane transporter activity
A6768_RS04680	COG1136	(ABC) transporter
A6768_RS04695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6768_RS04700	COG1024	Enoyl-CoA hydratase
A6768_RS04720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6768_RS04725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6768_RS04730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6768_RS04735	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6768_RS04770	COG4774	siderophore transport
A6768_RS04780	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS04815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6768_RS04840	COG1252	NADH dehydrogenase
A6768_RS04850	COG2116	formate transmembrane transporter activity
A6768_RS04865	COG4191	Histidine kinase
A6768_RS04865	COG0784	Response regulator, receiver
A6768_RS04870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6768_RS04875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6768_RS04925	COG4206	TonB-dependent receptor
A6768_RS04950	COG3750	Belongs to the UPF0335 family
A6768_RS04990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6768_RS05135	COG4695	Portal protein
A6768_RS05170	COG2308	Evidence 4 Homologs of previously reported genes of
A6768_RS05180	COG1305	Transglutaminase-like
A6768_RS05195	COG0492	ferredoxin-NADP+ reductase activity
A6768_RS05205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6768_RS05215	COG0318	PFAM AMP-dependent synthetase and ligase
A6768_RS05235	COG0489	protein tyrosine kinase activity
A6768_RS05245	COG3409	Peptidoglycan-binding domain 1 protein
A6768_RS05245	COG3267	Type II secretory pathway component ExeA
A6768_RS05265	COG0297	glycogen (starch) synthase activity
A6768_RS05275	COG0367	asparagine synthase
A6768_RS05280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6768_RS05320	COG2084	Dehydrogenase
A6768_RS05325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6768_RS05330	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6768_RS05350	COG1956	GAF domain-containing protein
A6768_RS05360	COG0564	pseudouridine synthase activity
A6768_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS05390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6768_RS05405	COG1741	Belongs to the pirin family
A6768_RS05435	COG1595	DNA-templated transcription, initiation
A6768_RS05445	COG4771	TonB-dependent receptor
A6768_RS05450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6768_RS05455	COG0717	Belongs to the dCTP deaminase family
A6768_RS05460	COG0295	cytidine deaminase activity
A6768_RS05470	COG5328	Belongs to the UPF0262 family
A6768_RS05475	COG0305	Participates in initiation and elongation during chromosome replication
A6768_RS05495	COG0175	sulfate reduction
A6768_RS05520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6768_RS05520	COG1648	precorrin-2 dehydrogenase activity
A6768_RS05525	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS05555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6768_RS05580	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6768_RS05590	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6768_RS05645	COG1506	peptidase
A6768_RS05645	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS05655	COG0583	DNA-binding transcription factor activity
A6768_RS05660	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A6768_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS05695	COG0025	NhaP-type Na H and K H
A6768_RS05700	COG0306	phosphate transporter
A6768_RS05720	COG1063	alcohol dehydrogenase
A6768_RS05725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6768_RS05730	COG1024	Enoyl-CoA hydratase
A6768_RS05755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6768_RS05760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6768_RS05770	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A6768_RS05800	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6768_RS05800	COG1024	Enoyl-CoA hydratase
A6768_RS05815	COG2814	Major facilitator Superfamily
A6768_RS05820	COG1960	acyl-CoA dehydrogenase activity
A6768_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS05855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6768_RS05865	COG0183	Belongs to the thiolase family
A6768_RS05875	COG1024	Enoyl-CoA hydratase
A6768_RS05885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6768_RS05890	COG3474	cytochrome
A6768_RS05900	COG0183	Belongs to the thiolase family
A6768_RS05905	COG1960	acyl-CoA dehydrogenase activity
A6768_RS05910	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A6768_RS05915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6768_RS05920	COG2130	NADP-dependent
A6768_RS05930	COG1960	acyl-CoA dehydrogenase activity
A6768_RS05935	COG2124	cytochrome p450
A6768_RS05950	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS05975	COG0772	Belongs to the SEDS family
A6768_RS06000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6768_RS06005	COG0616	signal peptide processing
A6768_RS06010	COG0588	phosphoglycerate mutase activity
A6768_RS06020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6768_RS06030	COG0196	riboflavin kinase activity
A6768_RS06035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6768_RS06040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6768_RS06065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6768_RS06070	COG3172	ATPase kinase involved in NAD metabolism
A6768_RS06090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6768_RS06090	COG0475	glutathione-regulated potassium exporter activity
A6768_RS06105	COG0667	Aldo Keto reductase
A6768_RS06110	COG1671	Belongs to the UPF0178 family
A6768_RS06115	COG2081	HI0933 family
A6768_RS06140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6768_RS06150	COG0314	molybdopterin synthase activity
A6768_RS06155	COG0583	DNA-binding transcription factor activity
A6768_RS06160	COG0730	response to heat
A6768_RS06165	COG1045	serine acetyltransferase
A6768_RS06175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6768_RS06205	COG1216	Glycosyl transferase, family 2
A6768_RS06210	COG1216	Glycosyl transferase, family 2
A6768_RS06210	COG0463	Glycosyl transferase, family 2
A6768_RS06230	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6768_RS06285	COG1858	cytochrome C peroxidase
A6768_RS06300	COG0598	Magnesium transport protein CorA
A6768_RS06320	COG0300	oxidoreductase activity
A6768_RS06350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6768_RS06355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6768_RS06360	COG2188	Transcriptional regulator
A6768_RS06370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6768_RS06375	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6768_RS06375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6768_RS06380	COG1263	PTS System
A6768_RS06380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6768_RS06385	COG0488	(ABC) transporter
A6768_RS06410	COG0457	Tetratricopeptide repeat
A6768_RS06425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6768_RS06435	COG2986	histidine ammonia-lyase
A6768_RS06440	COG1228	amidohydrolase
A6768_RS06450	COG2188	Transcriptional regulator
A6768_RS06455	COG1228	amidohydrolase
A6768_RS06465	COG1228	amidohydrolase
A6768_RS06480	COG3104	oligopeptide transport
A6768_RS06510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6768_RS06515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6768_RS06530	COG0531	amino acid
A6768_RS06540	COG4206	TonB-dependent receptor
A6768_RS06545	COG0405	Gamma-glutamyltransferase
A6768_RS06550	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS06555	COG3707	response regulator
A6768_RS06560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6768_RS06560	COG1116	anion transmembrane transporter activity
A6768_RS06565	COG2223	nitrite transmembrane transporter activity
A6768_RS06575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6768_RS06585	COG0243	molybdopterin cofactor binding
A6768_RS06590	COG1648	precorrin-2 dehydrogenase activity
A6768_RS06590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6768_RS06610	COG0488	(ABC) transporter
A6768_RS06615	COG1858	cytochrome C peroxidase
A6768_RS06625	COG4771	TonB-dependent receptor
A6768_RS06645	COG3766	membrane
A6768_RS06650	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6768_RS06660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A6768_RS06665	COG0583	DNA-binding transcription factor activity
A6768_RS06670	COG0667	Aldo Keto reductase
A6768_RS06675	COG2814	Major facilitator Superfamily
A6768_RS06715	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6768_RS06735	COG2197	response regulator
A6768_RS06740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6768_RS06750	COG1254	Belongs to the acylphosphatase family
A6768_RS06765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6768_RS06770	COG2867	negative regulation of translational initiation
A6768_RS06775	COG1546	Belongs to the CinA family
A6768_RS06780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6768_RS06780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6768_RS06800	COG5000	phosphorelay sensor kinase activity
A6768_RS06805	COG2204	response regulator
A6768_RS06810	COG1923	regulation of RNA biosynthetic process
A6768_RS06815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6768_RS06825	COG2252	PERMEase
A6768_RS06835	COG3956	TIGRFAM MazG family protein
A6768_RS06840	COG1132	(ABC) transporter
A6768_RS06915	COG1609	Transcriptional regulator
A6768_RS06965	COG0583	DNA-binding transcription factor activity
A6768_RS06970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6768_RS06980	COG2271	Major facilitator Superfamily
A6768_RS06995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6768_RS07005	COG0583	DNA-binding transcription factor activity
A6768_RS07015	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A6768_RS07035	COG0431	NADPH-dependent FMN reductase
A6768_RS07065	COG2814	Major facilitator Superfamily
A6768_RS07075	COG0477	Major facilitator Superfamily
A6768_RS07105	COG4771	TonB-dependent receptor
A6768_RS07125	COG0477	Major facilitator Superfamily
A6768_RS07140	COG0084	hydrolase, TatD family'
A6768_RS07155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6768_RS07160	COG1686	Belongs to the peptidase S11 family
A6768_RS07165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6768_RS07170	COG2951	lytic endotransglycosylase activity
A6768_RS07225	COG1475	DNA binding
A6768_RS07255	COG3001	Fructosamine kinase
A6768_RS07280	COG3916	Acyl-homoserine-lactone synthase
A6768_RS07315	COG1506	peptidase
A6768_RS07315	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS07340	COG2963	transposase activity
A6768_RS07345	COG3436	PFAM IS66 Orf2 family protein
A6768_RS07360	COG3920	Histidine kinase
A6768_RS07390	COG3685	Protein conserved in bacteria
A6768_RS07415	COG3546	catalase activity
A6768_RS07430	COG3920	Histidine kinase
A6768_RS07450	COG1058	Belongs to the CinA family
A6768_RS07450	COG1546	Belongs to the CinA family
A6768_RS07455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6768_RS07455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6768_RS07460	COG4221	oxidoreductase activity
A6768_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS07480	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A6768_RS07500	COG1640	4-alpha-glucanotransferase
A6768_RS07530	COG0583	DNA-binding transcription factor activity
A6768_RS07550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6768_RS07575	COG2207	Transcriptional regulator
A6768_RS07580	COG2814	Major facilitator Superfamily
A6768_RS07770	COG0071	Belongs to the small heat shock protein (HSP20) family
A6768_RS07775	COG0071	Belongs to the small heat shock protein (HSP20) family
A6768_RS07790	COG2095	MarC family integral membrane protein
A6768_RS07800	COG5425	PFAM Usg family protein
A6768_RS07810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6768_RS07815	COG0459	protein refolding
A6768_RS07830	COG0604	alcohol dehydrogenase
A6768_RS07830	COG3321	synthase
A6768_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS07835	COG1309	transcriptional regulator
A6768_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS07865	COG4221	oxidoreductase activity
A6768_RS07880	COG1309	transcriptional regulator
A6768_RS07885	COG0519	Catalyzes the synthesis of GMP from XMP
A6768_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS07915	COG1733	regulation of RNA biosynthetic process
A6768_RS07940	COG1960	acyl-CoA dehydrogenase activity
A6768_RS07975	COG5290	Psort location Cytoplasmic, score
A6768_RS07995	COG0492	ferredoxin-NADP+ reductase activity
A6768_RS08005	COG4191	Histidine kinase
A6768_RS08010	COG4566	intracellular signal transduction
A6768_RS08015	COG0745	RESPONSE REGULATOR receiver
A6768_RS08025	COG2814	Major facilitator Superfamily
A6768_RS08030	COG0583	DNA-binding transcription factor activity
A6768_RS08040	COG2080	2 iron, 2 sulfur cluster binding
A6768_RS08045	COG2010	Cytochrome c
A6768_RS08045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6768_RS08050	COG0783	Belongs to the Dps family
A6768_RS08055	COG2197	response regulator
A6768_RS08060	COG0587	DNA-directed DNA polymerase activity
A6768_RS08110	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS08130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6768_RS08135	COG3059	membrane
A6768_RS08145	COG0028	Belongs to the TPP enzyme family
A6768_RS08150	COG1914	H( )-stimulated, divalent metal cation uptake system
A6768_RS08155	COG4191	Histidine kinase
A6768_RS08200	COG4566	intracellular signal transduction
A6768_RS08205	COG4191	Histidine kinase
A6768_RS08215	COG2814	Major facilitator Superfamily
A6768_RS08220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6768_RS08240	COG0300	oxidoreductase activity
A6768_RS08245	COG0604	alcohol dehydrogenase
A6768_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS08270	COG0667	Aldo Keto reductase
A6768_RS08295	COG4566	intracellular signal transduction
A6768_RS08310	COG2010	Cytochrome c
A6768_RS08310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6768_RS08315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6768_RS08350	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A6768_RS08360	COG4221	oxidoreductase activity
A6768_RS08380	COG2267	carboxylic ester hydrolase activity
A6768_RS08385	COG4191	Histidine kinase
A6768_RS08425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6768_RS08430	COG1275	C4-dicarboxylate transporter malic acid transport protein
A6768_RS08465	COG0753	catalase activity
A6768_RS08480	COG0582	viral genome integration into host DNA
A6768_RS08495	COG1228	amidohydrolase
A6768_RS08520	COG4191	Histidine kinase
A6768_RS08525	COG2244	polysaccharide biosynthetic process
A6768_RS08575	COG0438	transferase activity, transferring glycosyl groups
A6768_RS08580	COG0463	Glycosyl transferase, family 2
A6768_RS08585	COG2327	Polysaccharide pyruvyl transferase
A6768_RS08590	COG1216	Glycosyl transferase, family 2
A6768_RS08600	COG0438	transferase activity, transferring glycosyl groups
A6768_RS08620	COG0653	protein targeting
A6768_RS08630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6768_RS08635	COG0483	inositol monophosphate 1-phosphatase activity
A6768_RS08640	COG0625	glutathione transferase activity
A6768_RS08650	COG1074	ATP-dependent DNA helicase activity
A6768_RS08660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6768_RS08665	COG3178	'Phosphotransferase
A6768_RS08670	COG0802	atpase or kinase
A6768_RS08675	COG2205	protein histidine kinase activity
A6768_RS08680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6768_RS08690	COG1678	Uncharacterized ACR, COG1678
A6768_RS08700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6768_RS08705	COG3447	MASE1 domain protein
A6768_RS08705	COG5002	protein histidine kinase activity
A6768_RS08705	COG5001	Diguanylate cyclase
A6768_RS08715	COG2267	carboxylic ester hydrolase activity
A6768_RS08725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6768_RS08745	COG2271	Major facilitator Superfamily
A6768_RS08760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6768_RS08765	COG4948	Mandelate Racemase Muconate Lactonizing
A6768_RS08770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6768_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS08780	COG0579	oxidoreductase
A6768_RS08790	COG1301	dicarboxylic acid transport
A6768_RS08795	COG4191	Histidine kinase
A6768_RS08800	COG2204	response regulator
A6768_RS08820	COG4555	ABC transporter
A6768_RS08850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6768_RS08855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6768_RS08875	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A6768_RS08885	COG0183	Belongs to the thiolase family
A6768_RS08895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6768_RS08900	COG0477	Major facilitator Superfamily
A6768_RS08905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6768_RS08910	COG4770	biotin carboxylase activity
A6768_RS08925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6768_RS08930	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6768_RS08930	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6768_RS08935	COG0346	lactoylglutathione lyase activity
A6768_RS08945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6768_RS08950	COG1396	sequence-specific DNA binding
A6768_RS08950	COG3800	Transcriptional regulator
A6768_RS08960	COG0583	DNA-binding transcription factor activity
A6768_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS08980	COG0166	Belongs to the GPI family
A6768_RS08990	COG0571	ribonuclease III activity
A6768_RS08995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6768_RS09000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6768_RS09005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6768_RS09005	COG1754	DNA topoisomerase type I activity
A6768_RS09015	COG0758	DNA mediated transformation
A6768_RS09020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6768_RS09030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6768_RS09035	COG0156	8-amino-7-oxononanoate synthase activity
A6768_RS09045	COG2226	methyltransferase
A6768_RS09060	COG1793	dna ligase
A6768_RS09070	COG1748	Saccharopine dehydrogenase
A6768_RS09075	COG0596	Alpha beta hydrolase
A6768_RS09090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6768_RS09095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6768_RS09095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6768_RS09110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6768_RS09130	COG0741	lytic transglycosylase activity
A6768_RS09135	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6768_RS09150	COG3158	transport of potassium into the cell
A6768_RS09160	COG3088	subunit of a heme lyase
A6768_RS09165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6768_RS09170	COG1138	Cytochrome C-type biogenesis protein
A6768_RS09175	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6768_RS09185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6768_RS09190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6768_RS09195	COG4221	oxidoreductase activity
A6768_RS09200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6768_RS09205	COG0415	Belongs to the DNA photolyase family
A6768_RS09210	COG1051	belongs to the nudix hydrolase family
A6768_RS09230	COG3724	N-succinylarginine dihydrolase activity
A6768_RS09255	COG1492	cobalamin metabolic process
A6768_RS09280	COG0052	Belongs to the universal ribosomal protein uS2 family
A6768_RS09285	COG0574	Belongs to the PEP-utilizing enzyme family
A6768_RS09285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6768_RS09290	COG0751	glycine-tRNA ligase activity
A6768_RS09295	COG0752	glycyl-tRNA synthetase alpha subunit
A6768_RS09310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6768_RS09315	COG0193	aminoacyl-tRNA hydrolase activity
A6768_RS09330	COG0033	Phosphoglucomutase
A6768_RS09345	COG0012	GTP binding
A6768_RS09365	COG2030	dehydratase
A6768_RS09365	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS09370	COG1280	lysine exporter protein (LysE YggA)
A6768_RS09375	COG2258	MOSC domain
A6768_RS09385	COG0297	glycogen (starch) synthase activity
A6768_RS09390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6768_RS09480	COG0617	tRNA 3'-terminal CCA addition
A6768_RS09485	COG2202	Pas domain
A6768_RS09485	COG2199	diguanylate cyclase activity
A6768_RS09485	COG2200	EAL domain
A6768_RS09490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6768_RS09505	COG0583	DNA-binding transcription factor activity
A6768_RS09510	COG1877	trehalose-phosphatase activity
A6768_RS09515	COG3387	PFAM Glycoside hydrolase 15-related
A6768_RS09520	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6768_RS09530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6768_RS09540	COG2223	nitrite transmembrane transporter activity
A6768_RS09550	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6768_RS09555	COG0047	phosphoribosylformylglycinamidine synthase activity
A6768_RS09575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6768_RS09590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6768_RS09595	COG0842	Transport permease protein
A6768_RS09615	COG0187	DNA topoisomerase II activity
A6768_RS09625	COG0583	DNA-binding transcription factor activity
A6768_RS09630	COG2967	ApaG domain
A6768_RS09640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6768_RS09650	COG0473	3-isopropylmalate dehydrogenase activity
A6768_RS09655	COG1381	Involved in DNA repair and RecF pathway recombination
A6768_RS09685	COG0322	excinuclease ABC activity
A6768_RS09690	COG1064	alcohol dehydrogenase
A6768_RS09705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6768_RS09710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6768_RS09715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6768_RS09720	COG0356	it plays a direct role in the translocation of protons across the membrane
A6768_RS09745	COG2003	Belongs to the UPF0758 family
A6768_RS09755	COG0513	Belongs to the DEAD box helicase family
A6768_RS09765	COG0277	FAD linked oxidase domain protein
A6768_RS09860	COG0596	Alpha beta hydrolase
A6768_RS09865	COG0583	DNA-binding transcription factor activity
A6768_RS09885	COG0297	glycogen (starch) synthase activity
A6768_RS09895	COG0745	RESPONSE REGULATOR receiver
A6768_RS09920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6768_RS09935	COG2197	response regulator
A6768_RS09950	COG4181	ATPase activity
A6768_RS10030	COG4771	TonB-dependent receptor
A6768_RS10035	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6768_RS10040	COG3119	arylsulfatase activity
A6768_RS10095	COG0557	exoribonuclease II activity
A6768_RS10110	COG0659	secondary active sulfate transmembrane transporter activity
A6768_RS10120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6768_RS10125	COG0134	indole-3-glycerol-phosphate synthase activity
A6768_RS10130	COG0315	cyclic pyranopterin monophosphate synthase activity
A6768_RS10140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6768_RS10145	COG0658	competence protein
A6768_RS10145	COG2333	competence protein COMEC
A6768_RS10150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6768_RS10155	COG0372	Belongs to the citrate synthase family
A6768_RS10165	COG2205	protein histidine kinase activity
A6768_RS10190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6768_RS10195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6768_RS10220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6768_RS10230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6768_RS10260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6768_RS10265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6768_RS10315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6768_RS10325	COG0235	Class ii aldolase
A6768_RS10335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6768_RS10350	COG1116	anion transmembrane transporter activity
A6768_RS10355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6768_RS10360	COG0583	DNA-binding transcription factor activity
A6768_RS10365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6768_RS10460	COG2860	membrane
A6768_RS10470	COG0386	Belongs to the glutathione peroxidase family
A6768_RS10480	COG0488	(ABC) transporter
A6768_RS10510	COG2832	Protein of unknown function (DUF454)
A6768_RS10520	COG1546	Belongs to the CinA family
A6768_RS10520	COG1058	Belongs to the CinA family
A6768_RS10530	COG0024	Methionine aminopeptidase
A6768_RS10535	COG0347	Belongs to the P(II) protein family
A6768_RS10540	COG0174	glutamine synthetase
A6768_RS10550	COG2070	2-Nitropropane dioxygenase
A6768_RS10570	COG0564	pseudouridine synthase activity
A6768_RS10575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6768_RS10605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6768_RS10610	COG0740	serine-type endopeptidase activity
A6768_RS10630	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6768_RS10650	COG3712	iron ion homeostasis
A6768_RS10680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6768_RS10685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6768_RS10720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6768_RS10725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6768_RS10730	COG1309	transcriptional regulator
A6768_RS10735	COG1228	amidohydrolase
A6768_RS10740	COG0612	Peptidase, M16
A6768_RS10745	COG0513	Belongs to the DEAD box helicase family
A6768_RS10755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6768_RS10765	COG0456	acetyltransferase
A6768_RS10765	COG1214	PFAM Peptidase M22, glycoprotease
A6768_RS10770	COG4957	zinc ion binding
A6768_RS10785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6768_RS10790	COG1702	phosphate starvation-inducible protein PhoH
A6768_RS10795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6768_RS10800	COG1253	flavin adenine dinucleotide binding
A6768_RS10810	COG0671	phosphoesterase, PA-phosphatase related
A6768_RS10815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6768_RS10820	COG1607	acyl-coa hydrolase
A6768_RS10825	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6768_RS10860	COG1335	isochorismatase
A6768_RS10865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6768_RS10870	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6768_RS10875	COG2080	2 iron, 2 sulfur cluster binding
A6768_RS10880	COG2211	Major facilitator Superfamily
A6768_RS10885	COG1609	Transcriptional regulator
A6768_RS10905	COG1940	carbohydrate kinase activity
A6768_RS10910	COG1621	beta-fructofuranosidase activity
A6768_RS10915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6768_RS10920	COG0583	DNA-binding transcription factor activity
A6768_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS10950	COG1764	response to oxidative stress
A6768_RS10955	COG0596	Alpha beta hydrolase
A6768_RS10980	COG0745	RESPONSE REGULATOR receiver
A6768_RS10985	COG5002	protein histidine kinase activity
A6768_RS10990	COG0583	DNA-binding transcription factor activity
A6768_RS10995	COG1073	alpha beta
A6768_RS11000	COG1073	alpha beta
A6768_RS11040	COG4771	TonB-dependent receptor
A6768_RS11050	COG2832	Protein of unknown function (DUF454)
A6768_RS11065	COG4774	siderophore transport
A6768_RS11120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6768_RS11135	COG1621	beta-fructofuranosidase activity
A6768_RS11140	COG2814	Major facilitator Superfamily
A6768_RS11145	COG1940	carbohydrate kinase activity
A6768_RS11150	COG1940	carbohydrate kinase activity
A6768_RS11160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6768_RS11160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6768_RS11165	COG1105	Belongs to the carbohydrate kinase PfkB family
A6768_RS11170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6768_RS11170	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6768_RS11175	COG1609	Transcriptional regulator
A6768_RS11180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6768_RS11185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6768_RS11190	COG1621	beta-fructofuranosidase activity
A6768_RS11195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6768_RS11280	COG0477	Major facilitator Superfamily
A6768_RS11310	COG0300	oxidoreductase activity
A6768_RS11315	COG1309	transcriptional regulator
A6768_RS11320	COG0604	alcohol dehydrogenase
A6768_RS11320	COG3321	synthase
A6768_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS11370	COG0667	Aldo Keto reductase
A6768_RS11520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6768_RS11560	COG3550	peptidyl-serine autophosphorylation
A6768_RS11600	COG0583	DNA-binding transcription factor activity
A6768_RS11610	COG0798	PFAM Bile acid sodium symporter
A6768_RS11630	COG4771	TonB-dependent receptor
A6768_RS11660	COG1192	Involved in chromosome partitioning
A6768_RS11725	COG0776	regulation of translation
A6768_RS11775	COG4974	Belongs to the 'phage' integrase family
A6768_RS11795	COG3093	addiction module antidote protein HigA
A6768_RS11815	COG1960	acyl-CoA dehydrogenase activity
A6768_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS11870	COG1024	Enoyl-CoA hydratase
A6768_RS11875	COG0183	Belongs to the thiolase family
A6768_RS11895	COG2192	nodulation
A6768_RS11910	COG0210	DNA helicase
A6768_RS11925	COG3591	Belongs to the peptidase S1B family
A6768_RS12020	COG4771	TonB-dependent receptor
A6768_RS12030	COG2086	electron transfer activity
A6768_RS12055	COG0175	sulfate reduction
A6768_RS12065	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6768_RS12080	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12095	COG2223	nitrite transmembrane transporter activity
A6768_RS12105	COG2124	cytochrome p450
A6768_RS12125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6768_RS12130	COG1024	Enoyl-CoA hydratase
A6768_RS12135	COG1902	pentaerythritol trinitrate reductase activity
A6768_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12155	COG0183	Belongs to the thiolase family
A6768_RS12165	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6768_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12205	COG1024	Enoyl-CoA hydratase
A6768_RS12210	COG0596	Alpha beta hydrolase
A6768_RS12245	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6768_RS12255	COG1960	acyl-CoA dehydrogenase activity
A6768_RS12280	COG4771	TonB-dependent receptor
A6768_RS12325	COG1960	acyl-CoA dehydrogenase activity
A6768_RS12330	COG1960	acyl-CoA dehydrogenase activity
A6768_RS12345	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6768_RS12350	COG1024	Enoyl-CoA hydratase
A6768_RS12370	COG1053	succinate dehydrogenase
A6768_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12395	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12425	COG1024	Enoyl-CoA hydratase
A6768_RS12430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6768_RS12440	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6768_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12460	COG0625	glutathione transferase activity
A6768_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12475	COG0583	DNA-binding transcription factor activity
A6768_RS12495	COG0183	Belongs to the thiolase family
A6768_RS12520	COG0183	Belongs to the thiolase family
A6768_RS12545	COG1309	transcriptional regulator
A6768_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12565	COG0604	alcohol dehydrogenase
A6768_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12605	COG2124	cytochrome p450
A6768_RS12615	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6768_RS12620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6768_RS12630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6768_RS12635	COG0302	gtp cyclohydrolase
A6768_RS12700	COG0583	DNA-binding transcription factor activity
A6768_RS12705	COG1301	dicarboxylic acid transport
A6768_RS12725	COG0477	Major facilitator Superfamily
A6768_RS12745	COG2271	Major facilitator Superfamily
A6768_RS12765	COG3507	Belongs to the glycosyl hydrolase 43 family
A6768_RS12770	COG3507	Belongs to the glycosyl hydrolase 43 family
A6768_RS12785	COG0475	glutathione-regulated potassium exporter activity
A6768_RS12835	COG1472	Belongs to the glycosyl hydrolase 3 family
A6768_RS12845	COG0657	acetylesterase activity
A6768_RS12845	COG2755	lipolytic protein G-D-S-L family
A6768_RS12855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6768_RS12870	COG2207	Transcriptional regulator
A6768_RS12915	COG2207	Transcriptional regulator
A6768_RS12930	COG0667	Aldo Keto reductase
A6768_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS12940	COG1309	transcriptional regulator
A6768_RS12995	COG2207	Transcriptional regulator
A6768_RS13010	COG1566	PFAM secretion protein HlyD family protein
A6768_RS13055	COG0667	Aldo Keto reductase
A6768_RS13060	COG0300	oxidoreductase activity
A6768_RS13090	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6768_RS13095	COG1595	DNA-templated transcription, initiation
A6768_RS13110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6768_RS13120	COG0745	RESPONSE REGULATOR receiver
A6768_RS13150	COG3547	Transposase (IS116 IS110 IS902 family)
A6768_RS13160	COG4974	Belongs to the 'phage' integrase family
A6768_RS13185	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS13185	COG1506	peptidase
A6768_RS13195	COG0482	sulfurtransferase activity
A6768_RS13235	COG0776	regulation of translation
A6768_RS13265	COG2963	transposase activity
A6768_RS13270	COG3436	PFAM IS66 Orf2 family protein
A6768_RS13275	COG2433	Pfam Transposase IS66
A6768_RS13310	COG0297	glycogen (starch) synthase activity
A6768_RS13365	COG4957	zinc ion binding
A6768_RS13375	COG0326	Molecular chaperone. Has ATPase activity
A6768_RS13380	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS13385	COG1733	regulation of RNA biosynthetic process
A6768_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS13430	COG1376	ErfK ybiS ycfS ynhG family protein
A6768_RS13435	COG3108	Peptidase M15
A6768_RS13445	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS13450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6768_RS13465	COG0582	viral genome integration into host DNA
A6768_RS13480	COG2202	Pas domain
A6768_RS13480	COG2205	protein histidine kinase activity
A6768_RS13485	COG1522	sequence-specific DNA binding
A6768_RS13500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6768_RS13520	COG0135	phosphoribosylanthranilate isomerase activity
A6768_RS13525	COG0133	tryptophan synthase activity
A6768_RS13530	COG0159	tryptophan synthase activity
A6768_RS13535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6768_RS13565	COG1187	pseudouridine synthase activity
A6768_RS13570	COG0742	ribosomal rna small subunit methyltransferase
A6768_RS13600	COG0210	DNA helicase
A6768_RS13625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6768_RS13630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6768_RS13635	COG0539	negative regulation of cytoplasmic translation
A6768_RS13640	COG0776	regulation of translation
A6768_RS13660	COG2066	Belongs to the glutaminase family
A6768_RS13675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6768_RS13690	COG0625	glutathione transferase activity
A6768_RS13695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6768_RS13700	COG0583	DNA-binding transcription factor activity
A6768_RS13705	COG0280	phosphate acetyltransferase
A6768_RS13705	COG0281	malic enzyme
A6768_RS13720	COG2814	Major facilitator Superfamily
A6768_RS13745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6768_RS13750	COG4771	TonB-dependent receptor
A6768_RS13775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6768_RS13790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6768_RS13815	COG2945	thiolester hydrolase activity
A6768_RS13840	COG2972	Histidine kinase
A6768_RS13875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6768_RS13905	COG1278	Cold shock
A6768_RS13930	COG2086	electron transfer activity
A6768_RS13935	COG0045	succinate-CoA ligase (ADP-forming) activity
A6768_RS13955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6768_RS13960	COG1215	transferase activity, transferring glycosyl groups
A6768_RS13990	COG0392	lysyltransferase activity
A6768_RS13990	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6768_RS13995	COG0346	lactoylglutathione lyase activity
A6768_RS14000	COG3507	Belongs to the glycosyl hydrolase 43 family
A6768_RS14035	COG2272	Belongs to the type-B carboxylesterase lipase family
A6768_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS14045	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6768_RS14050	COG1609	Transcriptional regulator
A6768_RS14060	COG2271	Major facilitator Superfamily
A6768_RS14070	COG0730	response to heat
A6768_RS14095	COG1294	oxidase, subunit
A6768_RS14105	COG4988	ABC transporter
A6768_RS14110	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6768_RS14115	COG0589	response to stress
A6768_RS14120	COG1960	acyl-CoA dehydrogenase activity
A6768_RS14130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6768_RS14145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6768_RS14180	COG0505	Belongs to the CarA family
A6768_RS14185	COG3537	Alpha-1,2-mannosidase
A6768_RS14195	COG3119	arylsulfatase activity
A6768_RS14200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6768_RS14205	COG2032	superoxide dismutase activity
A6768_RS14210	COG2885	chlorophyll binding
A6768_RS14210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6768_RS14320	COG4695	Portal protein
A6768_RS14340	COG0778	Nitroreductase
A6768_RS14355	COG2234	aminopeptidase activity
A6768_RS14440	COG0004	ammonium transporteR
A6768_RS14450	COG0477	Major facilitator Superfamily
A6768_RS14455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6768_RS14460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6768_RS14465	COG1845	cytochrome c oxidase, subunit III
A6768_RS14470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A6768_RS14475	COG3346	SURF1 family
A6768_RS14485	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A6768_RS14510	COG0463	Glycosyl transferase, family 2
A6768_RS14515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6768_RS14530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6768_RS14565	COG3206	protein involved in exopolysaccharide biosynthesis
A6768_RS14565	COG0489	protein tyrosine kinase activity
A6768_RS14570	COG2197	response regulator
A6768_RS14590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6768_RS14595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6768_RS14605	COG0438	transferase activity, transferring glycosyl groups
A6768_RS14615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6768_RS14625	COG1596	polysaccharide export
A6768_RS14635	COG0438	transferase activity, transferring glycosyl groups
A6768_RS14645	COG2274	protein secretion by the type I secretion system
A6768_RS14655	COG1846	Transcriptional regulator
A6768_RS14680	COG1024	Enoyl-CoA hydratase
A6768_RS14705	COG0540	Belongs to the ATCase OTCase family
A6768_RS14710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6768_RS14715	COG2199	diguanylate cyclase activity
A6768_RS14735	COG0250	Participates in transcription elongation, termination and antitermination
A6768_RS14740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6768_RS14745	COG0081	regulation of translation
A6768_RS14755	COG4651	solute:proton antiporter activity
A6768_RS14755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6768_RS14765	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6768_RS14770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6768_RS14790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6768_RS14795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6768_RS14800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6768_RS14825	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6768_RS14825	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6768_RS14840	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6768_RS14850	COG4133	protoheme IX ABC transporter activity
A6768_RS14855	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6768_RS14860	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6768_RS14865	COG2610	gluconate transmembrane transporter activity
A6768_RS14880	COG1605	Chorismate mutase
A6768_RS14880	COG0287	Prephenate dehydrogenase
A6768_RS14885	COG0142	geranyltranstransferase activity
A6768_RS14900	COG3119	arylsulfatase activity
A6768_RS14905	COG1643	Atp-dependent helicase
A6768_RS14920	COG0156	8-amino-7-oxononanoate synthase activity
A6768_RS14955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6768_RS14960	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6768_RS14965	COG0509	glycine decarboxylation via glycine cleavage system
A6768_RS14970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6768_RS14980	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6768_RS14990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6768_RS14995	COG0849	cell division
A6768_RS15000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6768_RS15005	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6768_RS15010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6768_RS15020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6768_RS15025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6768_RS15035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6768_RS15040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6768_RS15050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6768_RS15065	COG0275	rRNA processing
A6768_RS15085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6768_RS15090	COG3409	Peptidoglycan-binding domain 1 protein
A6768_RS15090	COG3773	Cell wall hydrolase
A6768_RS15100	COG0805	protein transport
A6768_RS15105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6768_RS15110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6768_RS15115	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6768_RS15120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6768_RS15125	COG1472	Belongs to the glycosyl hydrolase 3 family
A6768_RS15135	COG0018	arginyl-trna synthetase
A6768_RS15145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6768_RS15150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6768_RS15155	COG0328	RNA-DNA hybrid ribonuclease activity
A6768_RS15160	COG3422	double-strand break repair
A6768_RS15185	COG4964	Belongs to the GSP D family
A6768_RS15220	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6768_RS15225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6768_RS15230	COG1794	racemase activity, acting on amino acids and derivatives
A6768_RS15275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6768_RS15285	COG4716	Myosin-crossreactive antigen
A6768_RS15300	COG0037	tRNA processing
A6768_RS15320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6768_RS15325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6768_RS15380	COG5507	3-demethylubiquinone-9 3-methyltransferase
A6768_RS15405	COG1733	regulation of RNA biosynthetic process
A6768_RS15420	COG2070	2-Nitropropane dioxygenase
A6768_RS15430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6768_RS15455	COG0457	Tetratricopeptide repeat
A6768_RS15460	COG0642	Histidine kinase
A6768_RS15465	COG0745	RESPONSE REGULATOR receiver
A6768_RS15480	COG2851	Citrate transporter
A6768_RS15490	COG0861	Integral membrane protein TerC family
A6768_RS15495	COG0586	Pfam SNARE associated Golgi protein
A6768_RS15500	COG0667	Aldo Keto reductase
A6768_RS15505	COG3852	Histidine kinase
A6768_RS15520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6768_RS15525	COG1136	(ABC) transporter
A6768_RS15525	COG0577	efflux transmembrane transporter activity
A6768_RS15530	COG1136	(ABC) transporter
A6768_RS15530	COG0577	efflux transmembrane transporter activity
A6768_RS15535	COG3794	PFAM blue (type 1) copper domain protein
A6768_RS15560	COG2301	Belongs to the HpcH HpaI aldolase family
A6768_RS15565	COG0330	HflC and HflK could
A6768_RS15600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6768_RS15605	COG0745	RESPONSE REGULATOR receiver
A6768_RS15610	COG2205	protein histidine kinase activity
A6768_RS15615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6768_RS15620	COG1660	Displays ATPase and GTPase activities
A6768_RS15625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6768_RS15625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6768_RS15630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6768_RS15635	COG3706	GGDEF domain
A6768_RS15640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6768_RS15645	COG0477	Major facilitator Superfamily
A6768_RS15660	COG0335	large ribosomal subunit rRNA binding
A6768_RS15665	COG0336	Belongs to the RNA methyltransferase TrmD family
A6768_RS15690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6768_RS15695	COG0228	four-way junction DNA binding
A6768_RS15700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6768_RS15710	COG0531	amino acid
A6768_RS15715	COG2814	Major facilitator Superfamily
A6768_RS15725	COG1538	Outer membrane efflux protein
A6768_RS15740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6768_RS15740	COG1648	precorrin-2 dehydrogenase activity
A6768_RS15745	COG0019	diaminopimelate decarboxylase activity
A6768_RS15755	COG0165	Argininosuccinate lyase
A6768_RS15760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6768_RS15770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6768_RS15790	COG1131	(ABC) transporter
A6768_RS15800	COG2267	carboxylic ester hydrolase activity
A6768_RS15820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6768_RS15820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6768_RS15835	COG0670	Belongs to the BI1 family
A6768_RS15840	COG0789	Transcriptional regulator
A6768_RS15845	COG0215	cysteine-tRNA ligase activity
A6768_RS15855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6768_RS15865	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6768_RS15875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6768_RS15875	COG2755	lipolytic protein G-D-S-L family
A6768_RS15890	COG1301	dicarboxylic acid transport
A6768_RS15940	COG0642	Histidine kinase
A6768_RS15945	COG0745	RESPONSE REGULATOR receiver
A6768_RS15960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6768_RS15980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6768_RS15985	COG0408	coproporphyrinogen oxidase activity
A6768_RS16000	COG0321	lipoyl(octanoyl) transferase activity
A6768_RS16015	COG0602	queuosine metabolic process
A6768_RS16020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6768_RS16035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6768_RS16040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6768_RS16070	COG1987	bacterial-type flagellum assembly
A6768_RS16120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6768_RS16130	COG1677	Flagellar hook-basal body complex protein FliE
A6768_RS16145	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6768_RS16190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6768_RS16200	COG1558	bacterial-type flagellum-dependent cell motility
A6768_RS16205	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6768_RS16210	COG4786	Flagellar basal body rod
A6768_RS16215	COG4787	bacterial-type flagellum-dependent cell motility
A6768_RS16225	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6768_RS16230	COG1706	bacterial-type flagellum-dependent cell motility
A6768_RS16265	COG2205	protein histidine kinase activity
A6768_RS16280	COG0137	argininosuccinate synthase activity
A6768_RS16335	COG0583	DNA-binding transcription factor activity
A6768_RS16340	COG4771	TonB-dependent receptor
A6768_RS16345	COG1392	Phosphate transport regulator
A6768_RS16350	COG0306	phosphate transporter
A6768_RS16355	COG3800	Transcriptional regulator
A6768_RS16355	COG1396	sequence-specific DNA binding
A6768_RS16375	COG1278	Cold shock
A6768_RS16400	COG0406	alpha-ribazole phosphatase activity
A6768_RS16405	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6768_RS16410	COG0517	IMP dehydrogenase activity
A6768_RS16410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6768_RS16445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6768_RS16455	COG1758	RNA polymerase activity
A6768_RS16485	COG3850	Histidine kinase
A6768_RS16485	COG0642	Histidine kinase
A6768_RS16490	COG0745	RESPONSE REGULATOR receiver
A6768_RS16495	COG0730	response to heat
A6768_RS16500	COG0686	Belongs to the AlaDH PNT family
A6768_RS16505	COG1522	sequence-specific DNA binding
A6768_RS16520	COG0582	viral genome integration into host DNA
A6768_RS16585	COG3657	addiction module killer protein
A6768_RS16590	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6768_RS16740	COG4695	Portal protein
A6768_RS16760	COG2267	carboxylic ester hydrolase activity
A6768_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS16815	COG2814	Major facilitator Superfamily
A6768_RS16820	COG3135	benzoate transporter
A6768_RS16830	COG0668	transmembrane transport
A6768_RS16835	COG0477	Major facilitator Superfamily
A6768_RS16845	COG0527	aspartate kinase activity
A6768_RS16850	COG5285	phytanoyl-CoA dioxygenase
A6768_RS16855	COG1917	Cupin 2, conserved barrel domain protein
A6768_RS16860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6768_RS16905	COG4999	Histidine kinase
A6768_RS16905	COG3437	response regulator, receiver
A6768_RS16905	COG3850	Histidine kinase
A6768_RS16905	COG2205	protein histidine kinase activity
A6768_RS16935	COG2843	Capsule synthesis protein
A6768_RS16950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6768_RS16965	COG2814	Major facilitator Superfamily
A6768_RS16970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6768_RS16980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A6768_RS16980	COG1082	Xylose isomerase domain protein TIM barrel
A6768_RS17025	COG4206	TonB-dependent receptor
A6768_RS17030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6768_RS17070	COG2095	MarC family integral membrane protein
A6768_RS17080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6768_RS17100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6768_RS17110	COG2202	Pas domain
A6768_RS17110	COG2205	protein histidine kinase activity
A6768_RS17130	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS17140	COG2205	protein histidine kinase activity
A6768_RS17200	COG3265	gluconokinase activity
A6768_RS17210	COG3254	rhamnose metabolic process
A6768_RS17215	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS17220	COG2721	sulfolactate sulfo-lyase activity
A6768_RS17240	COG0738	Major facilitator superfamily
A6768_RS17255	COG0657	acetylesterase activity
A6768_RS17255	COG2755	lipolytic protein G-D-S-L family
A6768_RS17275	COG1501	Belongs to the glycosyl hydrolase 31 family
A6768_RS17275	COG1501	Belongs to the glycosyl hydrolase 31 family
A6768_RS17280	COG2723	6-phospho-beta-galactosidase activity
A6768_RS17290	COG1522	sequence-specific DNA binding
A6768_RS17305	COG1082	Xylose isomerase domain protein TIM barrel
A6768_RS17310	COG0366	Alpha amylase catalytic
A6768_RS17320	COG1609	Transcriptional regulator
A6768_RS17340	COG0842	Transport permease protein
A6768_RS17345	COG1129	ABC transporter
A6768_RS17345	COG0842	Transport permease protein
A6768_RS17350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6768_RS17385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6768_RS17395	COG4566	intracellular signal transduction
A6768_RS17410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6768_RS17425	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6768_RS17430	COG4206	TonB-dependent receptor
A6768_RS17455	COG3940	Belongs to the glycosyl hydrolase 43 family
A6768_RS17485	COG2159	amidohydrolase
A6768_RS17495	COG0583	DNA-binding transcription factor activity
A6768_RS17500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6768_RS17510	COG3618	amidohydrolase
A6768_RS17530	COG1024	Enoyl-CoA hydratase
A6768_RS17550	COG0583	DNA-binding transcription factor activity
A6768_RS17575	COG0714	Associated with various cellular activities
A6768_RS17595	COG3128	pkhd-type hydroxylase
A6768_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS17615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6768_RS17625	COG1832	CoA-binding protein
A6768_RS17635	COG0454	-acetyltransferase
A6768_RS17640	COG0489	protein tyrosine kinase activity
A6768_RS17645	COG0330	HflC and HflK could
A6768_RS17650	COG0330	HflC and HflK could
A6768_RS17660	COG0433	COG0433 Predicted ATPase
A6768_RS17665	COG2814	Major facilitator Superfamily
A6768_RS17685	COG0085	RNA polymerase activity
A6768_RS17690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6768_RS17735	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A6768_RS17740	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A6768_RS17745	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A6768_RS17750	COG2205	protein histidine kinase activity
A6768_RS17755	COG0745	RESPONSE REGULATOR receiver
A6768_RS17760	COG3158	transport of potassium into the cell
A6768_RS17780	COG0745	RESPONSE REGULATOR receiver
A6768_RS17785	COG5002	protein histidine kinase activity
A6768_RS17790	COG3386	PFAM SMP-30 Gluconolaconase
A6768_RS17805	COG2186	Transcriptional regulator
A6768_RS17830	COG3940	Belongs to the glycosyl hydrolase 43 family
A6768_RS17875	COG3104	oligopeptide transport
A6768_RS17880	COG1228	amidohydrolase
A6768_RS17890	COG0402	S-adenosylhomocysteine deaminase activity
A6768_RS17900	COG1940	carbohydrate kinase activity
A6768_RS17905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6768_RS17915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6768_RS17920	COG4771	TonB-dependent receptor
A6768_RS17925	COG0402	S-adenosylhomocysteine deaminase activity
A6768_RS17930	COG0583	DNA-binding transcription factor activity
A6768_RS17950	COG4221	oxidoreductase activity
A6768_RS17955	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A6768_RS17975	COG2132	Multicopper oxidase
A6768_RS18000	COG3250	beta-galactosidase activity
A6768_RS18010	COG4774	siderophore transport
A6768_RS18015	COG0583	DNA-binding transcription factor activity
A6768_RS18020	COG4771	TonB-dependent receptor
A6768_RS18025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6768_RS18030	COG3047	cAMP biosynthetic process
A6768_RS18045	COG4191	Histidine kinase
A6768_RS18050	COG4566	intracellular signal transduction
A6768_RS18055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6768_RS18060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6768_RS18070	COG0194	GDP metabolic process
A6768_RS18100	COG0131	Imidazoleglycerol-phosphate dehydratase
A6768_RS18110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6768_RS18115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6768_RS18120	COG0107	imidazoleglycerol-phosphate synthase activity
A6768_RS18130	COG0140	phosphoribosyl-ATP diphosphatase activity
A6768_RS18140	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6768_RS18145	COG2989	Protein conserved in bacteria
A6768_RS18175	COG0546	phosphoglycolate phosphatase activity
A6768_RS18180	COG0564	pseudouridine synthase activity
A6768_RS18185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6768_RS18235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6768_RS18275	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A6768_RS18280	COG0109	protoheme IX farnesyltransferase activity
A6768_RS18285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6768_RS18295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6768_RS18300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6768_RS18305	COG0736	holo-[acyl-carrier-protein] synthase activity
A6768_RS18325	COG0545	Peptidyl-prolyl cis-trans isomerase
A6768_RS18330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6768_RS18350	COG1959	2 iron, 2 sulfur cluster binding
A6768_RS18355	COG0492	ferredoxin-NADP+ reductase activity
A6768_RS18390	COG0402	S-adenosylhomocysteine deaminase activity
A6768_RS18400	COG2239	Acts as a magnesium transporter
A6768_RS18430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6768_RS18440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6768_RS18450	COG1741	Belongs to the pirin family
A6768_RS18460	COG1741	Belongs to the pirin family
A6768_RS18465	COG0583	DNA-binding transcription factor activity
A6768_RS18470	COG2319	Wd-40 repeat
A6768_RS18495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6768_RS18520	COG3534	alpha-L-arabinofuranosidase
A6768_RS18545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6768_RS18550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6768_RS18555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6768_RS18555	COG2813	Specifically methylates the guanine in position
A6768_RS18570	COG0300	oxidoreductase activity
A6768_RS18590	COG0741	lytic transglycosylase activity
A6768_RS18595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6768_RS18600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6768_RS18615	COG0745	RESPONSE REGULATOR receiver
A6768_RS18620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6768_RS18630	COG0840	transmembrane signaling receptor activity
A6768_RS18635	COG2326	polyphosphate kinase activity
A6768_RS18645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6768_RS18650	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6768_RS18705	COG0481	GTPase activity
A6768_RS18715	COG0563	adenylate kinase activity
A6768_RS18720	COG0201	protein transport
A6768_RS18725	COG0200	Binds to the 23S rRNA
A6768_RS18730	COG1841	ribosomal large subunit assembly
A6768_RS18735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6768_RS18740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6768_RS18745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6768_RS18750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6768_RS18755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6768_RS18760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6768_RS18765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6768_RS18770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6768_RS18775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6768_RS18780	COG0255	Belongs to the universal ribosomal protein uL29 family
A6768_RS18785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6768_RS18790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6768_RS18795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6768_RS18800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6768_RS18805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6768_RS18810	COG0089	rRNA binding
A6768_RS18815	COG0088	Forms part of the polypeptide exit tunnel
A6768_RS18820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6768_RS18825	COG0051	transcription antitermination factor activity, RNA binding
A6768_RS18830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6768_RS18835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6768_RS18840	COG0049	tRNA binding
A6768_RS18845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6768_RS18850	COG3300	MHYT domain
A6768_RS18850	COG5001	Diguanylate cyclase
A6768_RS18855	COG0739	heme binding
A6768_RS18870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6768_RS18905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6768_RS18910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6768_RS18915	COG1862	Preprotein translocase
A6768_RS18960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6768_RS18965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6768_RS18970	COG0202	RNA polymerase activity
A6768_RS18975	COG0203	ribosomal protein L17
A6768_RS18980	COG1505	serine-type exopeptidase activity
A6768_RS19015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6768_RS19025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6768_RS19030	COG3590	peptidase
A6768_RS19045	COG2885	chlorophyll binding
A6768_RS19050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6768_RS19055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6768_RS19060	COG0424	maF-like protein
A6768_RS19070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6768_RS19080	COG0582	viral genome integration into host DNA
A6768_RS19090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6768_RS19125	COG0071	Belongs to the small heat shock protein (HSP20) family
A6768_RS19130	COG0071	Belongs to the small heat shock protein (HSP20) family
A6768_RS19205	COG3220	belongs to the UPF0276 family
A6768_RS19215	COG4944	Protein of unknown function (DUF1109)
A6768_RS19235	COG1733	regulation of RNA biosynthetic process
A6768_RS19255	COG4221	oxidoreductase activity
A6768_RS19265	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A6768_RS19280	COG1595	DNA-templated transcription, initiation
A6768_RS19285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6768_RS19315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6768_RS19330	COG3001	Fructosamine kinase
A6768_RS19365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6768_RS19395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6768_RS19415	COG4221	oxidoreductase activity
A6768_RS19430	COG2832	Protein of unknown function (DUF454)
A6768_RS19440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6768_RS19470	COG0583	DNA-binding transcription factor activity
A6768_RS19475	COG0789	Transcriptional regulator
A6768_RS19480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6768_RS19485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6768_RS19505	COG4774	siderophore transport
A6768_RS19515	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6768_RS19520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6768_RS19525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6768_RS19530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6768_RS19535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6768_RS19545	COG0482	sulfurtransferase activity
A6768_RS19565	COG2261	transglycosylase associated protein
A6768_RS19570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6768_RS19580	COG2733	membrane
A6768_RS19600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6768_RS19600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6768_RS19615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6768_RS19620	COG1902	pentaerythritol trinitrate reductase activity
A6768_RS19645	COG0629	single-stranded DNA binding
A6768_RS19670	COG0501	Belongs to the peptidase M48B family
A6768_RS19700	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS19700	COG1506	peptidase
A6768_RS19700	COG4946	Tricorn protease homolog
A6768_RS19705	COG0138	bifunctional purine biosynthesis protein purh
A6768_RS19715	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
A6768_RS19740	COG4152	abc transporter atp-binding protein
A6768_RS19745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6768_RS19760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6768_RS19770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6768_RS19775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6768_RS19780	COG0181	hydroxymethylbilane synthase activity
A6768_RS19805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6768_RS19805	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6768_RS19835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6768_RS19845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6768_RS19860	COG1476	TRANSCRIPTIONal
A6768_RS19865	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6768_RS19880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6768_RS19885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6768_RS19890	COG1280	lysine exporter protein (LysE YggA)
A6768_RS19900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6768_RS19905	COG0072	phenylalanine-tRNA ligase activity
A6768_RS19925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6768_RS19930	COG2814	Major facilitator Superfamily
A6768_RS19950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6768_RS19955	COG0287	Prephenate dehydrogenase
A6768_RS19975	COG2884	Cell division ATP-binding protein ftsE
A6768_RS19985	COG1741	Belongs to the pirin family
A6768_RS20000	COG0443	Heat shock 70 kDa protein
A6768_RS20020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6768_RS20025	COG0783	Belongs to the Dps family
A6768_RS20040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6768_RS20050	COG0784	Response regulator, receiver
A6768_RS20085	COG2814	Major facilitator Superfamily
A6768_RS20100	COG0531	amino acid
A6768_RS20105	COG1496	oxidoreductase activity
A6768_RS20110	COG2186	Transcriptional regulator
A6768_RS20150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6768_RS20165	COG1129	ABC transporter
A6768_RS20170	COG4214	carbohydrate transport
A6768_RS20180	COG0673	inositol 2-dehydrogenase activity
A6768_RS20185	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS20210	COG1850	ribulose-bisphosphate carboxylase activity
A6768_RS20240	COG3940	Belongs to the glycosyl hydrolase 43 family
A6768_RS20260	COG0277	FAD linked oxidase domain protein
A6768_RS20265	COG2186	Transcriptional regulator
A6768_RS20275	COG2814	Major facilitator Superfamily
A6768_RS20290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6768_RS20295	COG3958	Transketolase
A6768_RS20300	COG3959	Transketolase, thiamine diphosphate binding domain
A6768_RS20310	COG1082	Xylose isomerase domain protein TIM barrel
A6768_RS20315	COG3250	beta-galactosidase activity
A6768_RS20355	COG0667	Aldo Keto reductase
A6768_RS20360	COG0175	sulfate reduction
A6768_RS20370	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6768_RS20375	COG2272	Belongs to the type-B carboxylesterase lipase family
A6768_RS20405	COG2175	clavaminate synthase activity
A6768_RS20410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6768_RS20450	COG1960	acyl-CoA dehydrogenase activity
A6768_RS20455	COG1024	Enoyl-CoA hydratase
A6768_RS20470	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS20495	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS20505	COG0318	PFAM AMP-dependent synthetase and ligase
A6768_RS20510	COG0604	alcohol dehydrogenase
A6768_RS20525	COG0300	oxidoreductase activity
A6768_RS20540	COG0457	Tetratricopeptide repeat
A6768_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS20555	COG1063	alcohol dehydrogenase
A6768_RS20565	COG0175	sulfate reduction
A6768_RS20575	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6768_RS20590	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS20605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6768_RS20630	COG4638	Rieske (2fe-2S)
A6768_RS20640	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS20660	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A6768_RS20670	COG1960	acyl-CoA dehydrogenase activity
A6768_RS20690	COG0183	Belongs to the thiolase family
A6768_RS20705	COG0366	Alpha amylase catalytic
A6768_RS20715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6768_RS20730	COG2205	protein histidine kinase activity
A6768_RS20755	COG4993	Dehydrogenase
A6768_RS20775	COG0427	acetyl-CoA hydrolase
A6768_RS20785	COG0318	PFAM AMP-dependent synthetase and ligase
A6768_RS20805	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS20875	COG2244	polysaccharide biosynthetic process
A6768_RS20910	COG2890	protein-(glutamine-N5) methyltransferase activity
A6768_RS20915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6768_RS20930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6768_RS20935	COG0436	Aminotransferase
A6768_RS20940	COG2364	Membrane
A6768_RS20965	COG2818	Glycosylase
A6768_RS20980	COG1201	RNA secondary structure unwinding
A6768_RS20995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6768_RS21010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6768_RS21015	COG1127	ABC transporter
A6768_RS21030	COG0308	aminopeptidase N
A6768_RS21045	COG0357	Ribosomal RNA small subunit methyltransferase G
A6768_RS21050	COG0445	tRNA wobble uridine modification
A6768_RS21055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6768_RS21080	COG0861	Integral membrane protein TerC family
A6768_RS21085	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6768_RS21095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6768_RS21100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6768_RS21115	COG0495	leucyl-tRNA aminoacylation
A6768_RS21145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6768_RS21175	COG2983	Belongs to the UPF0260 family
A6768_RS21180	COG1999	signal sequence binding
A6768_RS21210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6768_RS21215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6768_RS21220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6768_RS21225	COG0237	dephospho-CoA kinase activity
A6768_RS21230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6768_RS21245	COG0424	maF-like protein
A6768_RS21250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6768_RS21255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6768_RS21260	COG1981	membrane
A6768_RS21270	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6768_RS21275	COG1192	Involved in chromosome partitioning
A6768_RS21295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6768_RS21315	COG1674	ftsk spoiiie
A6768_RS21340	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6768_RS21345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6768_RS21350	COG0280	phosphate acetyltransferase
A6768_RS21350	COG0281	malic enzyme
A6768_RS21375	COG1609	Transcriptional regulator
A6768_RS21380	COG1904	glucuronate isomerase
A6768_RS21385	COG2721	sulfolactate sulfo-lyase activity
A6768_RS21390	COG0776	regulation of translation
A6768_RS21405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6768_RS21430	COG2267	carboxylic ester hydrolase activity
A6768_RS21455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6768_RS21470	COG2255	four-way junction helicase activity
A6768_RS21480	COG0632	four-way junction helicase activity
A6768_RS21510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6768_RS21515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6768_RS21520	COG0436	Aminotransferase
A6768_RS21525	COG1196	nuclear chromosome segregation
A6768_RS21545	COG1194	a g-specific adenine glycosylase
A6768_RS21555	COG0312	modulator of DNA gyrase
A6768_RS21560	COG0483	inositol monophosphate 1-phosphatase activity
A6768_RS21575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6768_RS21575	COG3743	rRNA binding
A6768_RS21580	COG0151	Belongs to the GarS family
A6768_RS21585	COG1570	exodeoxyribonuclease VII activity
A6768_RS21625	COG0542	response to heat
A6768_RS21635	COG0612	Peptidase, M16
A6768_RS21660	COG1566	PFAM secretion protein HlyD family protein
A6768_RS21685	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS21690	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6768_RS21700	COG1139	Iron-sulfur cluster binding protein
A6768_RS21705	COG0247	lactate metabolic process
A6768_RS21710	COG0657	acetylesterase activity
A6768_RS21710	COG2755	lipolytic protein G-D-S-L family
A6768_RS21715	COG2755	lipolytic protein G-D-S-L family
A6768_RS21725	COG1414	Transcriptional regulator
A6768_RS21730	COG4948	Mandelate Racemase Muconate Lactonizing
A6768_RS21740	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS21795	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6768_RS21805	COG3254	rhamnose metabolic process
A6768_RS21815	COG2755	lipolytic protein G-D-S-L family
A6768_RS21825	COG1414	Transcriptional regulator
A6768_RS21830	COG2885	chlorophyll binding
A6768_RS21835	COG0823	Involved in the tonB-independent uptake of proteins
A6768_RS21855	COG0824	Thioesterase
A6768_RS21860	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6768_RS21865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6768_RS21870	COG1842	Phage shock protein A
A6768_RS21915	COG0405	Gamma-glutamyltransferase
A6768_RS21920	COG0167	dihydroorotate dehydrogenase activity
A6768_RS21935	COG0719	Fe-S assembly protein
A6768_RS21950	COG0396	ATPase activity
A6768_RS21955	COG0719	Fe-S assembly protein
A6768_RS21965	COG2151	metal-sulfur cluster biosynthetic enzyme
A6768_RS21970	COG0316	Belongs to the HesB IscA family
A6768_RS21990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6768_RS21995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6768_RS22000	COG3038	cytochrome b561
A6768_RS22005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6768_RS22020	COG0583	DNA-binding transcription factor activity
A6768_RS22025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6768_RS22040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6768_RS22045	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6768_RS22080	COG2307	Protein conserved in bacteria
A6768_RS22080	COG2308	Evidence 4 Homologs of previously reported genes of
A6768_RS22095	COG1505	serine-type exopeptidase activity
A6768_RS22105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6768_RS22165	COG1960	acyl-CoA dehydrogenase activity
A6768_RS22170	COG2146	nitrite reductase [NAD(P)H] activity
A6768_RS22175	COG1960	acyl-CoA dehydrogenase activity
A6768_RS22180	COG1960	acyl-CoA dehydrogenase activity
A6768_RS22190	COG4638	Rieske (2fe-2S)
A6768_RS22210	COG0427	acetyl-CoA hydrolase
A6768_RS22220	COG4638	Rieske (2fe-2S)
A6768_RS22240	COG1024	Enoyl-CoA hydratase
A6768_RS22245	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6768_RS22255	COG0318	PFAM AMP-dependent synthetase and ligase
A6768_RS22285	COG0183	Belongs to the thiolase family
A6768_RS22290	COG2814	Major facilitator Superfamily
A6768_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS22310	COG0300	oxidoreductase activity
A6768_RS22335	COG2814	Major facilitator Superfamily
A6768_RS22380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6768_RS22385	COG0022	dehydrogenase e1 component
A6768_RS22390	COG1522	sequence-specific DNA binding
A6768_RS22395	COG3186	Phenylalanine-4-hydroxylase
A6768_RS22400	COG1448	Aminotransferase
A6768_RS22410	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6768_RS22420	COG0625	glutathione transferase activity
A6768_RS22445	COG0778	Nitroreductase
A6768_RS22450	COG5265	(ABC) transporter
A6768_RS22465	COG2850	peptidyl-arginine hydroxylation
A6768_RS22470	COG0746	molybdenum cofactor guanylyltransferase activity
A6768_RS22475	COG0475	glutathione-regulated potassium exporter activity
A6768_RS22505	COG0673	inositol 2-dehydrogenase activity
A6768_RS22550	COG1609	Transcriptional regulator
A6768_RS22565	COG1940	carbohydrate kinase activity
A6768_RS22585	COG4974	Belongs to the 'phage' integrase family
A6768_RS22615	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A6768_RS22620	COG1285	pathogenesis
A6768_RS22650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6768_RS22655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6768_RS22655	COG2010	Cytochrome c
A6768_RS22690	COG1024	Enoyl-CoA hydratase
A6768_RS22690	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6768_RS22695	COG0427	acetyl-CoA hydrolase
A6768_RS22700	COG2116	formate transmembrane transporter activity
A6768_RS22760	COG0753	catalase activity
A6768_RS22770	COG0784	Response regulator, receiver
A6768_RS22770	COG4191	Histidine kinase
A6768_RS22780	COG0784	Response regulator, receiver
A6768_RS22790	COG0366	Alpha amylase catalytic
A6768_RS22800	COG0693	protein deglycase activity
A6768_RS22820	COG0438	transferase activity, transferring glycosyl groups
A6768_RS22830	COG0628	permease
A6768_RS22840	COG4297	protein containing double-stranded beta helix domain
A6768_RS22850	COG0069	glutamate synthase activity
A6768_RS22855	COG0028	Belongs to the TPP enzyme family
A6768_RS22865	COG1695	Transcriptional regulator
A6768_RS22885	COG4529	Protein conserved in bacteria
A6768_RS22890	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS22915	COG0741	lytic transglycosylase activity
A6768_RS22960	COG5489	Protein of unknown function (DUF736)
A6768_RS23000	COG2771	luxR family
A6768_RS23065	COG0302	gtp cyclohydrolase
A6768_RS23070	COG4566	intracellular signal transduction
A6768_RS23140	COG3046	protein related to deoxyribodipyrimidine photolyase
A6768_RS23150	COG1309	transcriptional regulator
A6768_RS23160	COG2197	response regulator
A6768_RS23180	COG1196	nuclear chromosome segregation
A6768_RS23180	COG3264	Mechanosensitive ion channel
A6768_RS23200	COG0798	PFAM Bile acid sodium symporter
A6768_RS23215	COG1204	response to ionizing radiation
A6768_RS23250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6768_RS23255	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6768_RS23260	COG2080	2 iron, 2 sulfur cluster binding
A6768_RS23280	COG0587	DNA-directed DNA polymerase activity
A6768_RS23310	COG4962	Type ii secretion system protein e
A6768_RS23325	COG3451	type IV secretory pathway VirB4
A6768_RS23395	COG1278	Cold shock
A6768_RS23450	COG0006	proline dipeptidase activity
A6768_RS23470	COG4206	TonB-dependent receptor
A6768_RS23480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6768_RS23490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6768_RS23510	COG2171	N-acyltransferase activity
A6768_RS23530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6768_RS23535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6768_RS23540	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6768_RS23550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6768_RS23570	COG1301	dicarboxylic acid transport
A6768_RS23575	COG3781	membrane
A6768_RS23580	COG1301	dicarboxylic acid transport
A6768_RS23585	COG0259	pyridoxamine-phosphate oxidase activity
A6768_RS23590	COG0484	heat shock protein binding
A6768_RS23595	COG1295	ribonuclease BN
A6768_RS23600	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6768_RS23605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6768_RS23610	COG0471	metal ion transport
A6768_RS23610	COG3273	potassium ion transport
A6768_RS23630	COG0514	ATP-dependent DNA helicase (RecQ)
A6768_RS23640	COG1230	cation diffusion facilitator family transporter
A6768_RS23670	COG0004	ammonium transporteR
A6768_RS23675	COG0347	Belongs to the P(II) protein family
A6768_RS23685	COG0312	modulator of DNA gyrase
A6768_RS23715	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6768_RS23720	COG1137	ATPase activity
A6768_RS23735	COG2211	Major facilitator Superfamily
A6768_RS23750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6768_RS23755	COG0243	molybdopterin cofactor binding
A6768_RS23785	COG1968	undecaprenyl-diphosphatase activity
A6768_RS23790	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6768_RS23795	COG2119	membrane
A6768_RS23815	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A6768_RS23825	COG0793	Belongs to the peptidase S41A family
A6768_RS23840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6768_RS23845	COG0799	negative regulation of ribosome biogenesis
A6768_RS23850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6768_RS23855	COG1322	Protein conserved in bacteria
A6768_RS23870	COG0300	oxidoreductase activity
A6768_RS23890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6768_RS23900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6768_RS23900	COG0519	Catalyzes the synthesis of GMP from XMP
A6768_RS23915	COG0412	Dienelactone hydrolase
A6768_RS23920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6768_RS23935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6768_RS23970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6768_RS23975	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6768_RS24000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6768_RS24015	COG5001	Diguanylate cyclase
A6768_RS24015	COG3300	MHYT domain
A6768_RS24025	COG2234	aminopeptidase activity
A6768_RS24080	COG0556	nucleotide-excision repair
A6768_RS24150	COG4774	siderophore transport
A6768_RS24160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6768_RS24160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6768_RS24170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6768_RS24170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6768_RS24220	COG1393	Belongs to the ArsC family
A6768_RS24225	COG0584	glycerophosphoryl diester phosphodiesterase
A6768_RS24230	COG1959	2 iron, 2 sulfur cluster binding
A6768_RS24235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6768_RS24245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6768_RS24250	COG0416	fatty acid biosynthetic process
A6768_RS24255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6768_RS24260	COG0776	regulation of translation
A6768_RS24280	COG1199	ATP-dependent helicase activity
A6768_RS24280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6768_RS24290	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6768_RS24315	COG4251	negative regulation of phosphorylation
A6768_RS24345	COG0436	Aminotransferase
A6768_RS24350	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6768_RS24360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6768_RS24375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6768_RS24380	COG0753	catalase activity
A6768_RS24395	COG1494	fructose-1,6-bisphosphatase
A6768_RS24440	COG1132	(ABC) transporter
A6768_RS24450	COG4948	Mandelate Racemase Muconate Lactonizing
A6768_RS24500	COG2932	Transcriptional regulator
A6768_RS24505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A6768_RS24510	COG2879	small protein
A6768_RS24515	COG1966	Carbon starvation protein
A6768_RS24540	COG2824	Alkylphosphonate utilization operon protein PhnA
A6768_RS24545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6768_RS24550	COG0706	membrane insertase activity
A6768_RS24555	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6768_RS24560	COG0594	ribonuclease P activity
A6768_RS24565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6768_RS24580	COG1530	ribonuclease E activity
A6768_RS24585	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6768_RS24590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6768_RS24625	COG0626	cystathionine gamma-synthase activity
A6768_RS24630	COG2897	thiosulfate sulfurtransferase activity
A6768_RS24640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6768_RS24670	COG1297	OPT oligopeptide transporter protein
A6768_RS24690	COG0582	viral genome integration into host DNA
A6768_RS24705	COG3750	Belongs to the UPF0335 family
A6768_RS24760	COG3657	addiction module killer protein
A6768_RS24765	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6768_RS24910	COG4695	Portal protein
A6768_RS24925	COG3206	protein involved in exopolysaccharide biosynthesis
A6768_RS24925	COG0489	protein tyrosine kinase activity
A6768_RS24955	COG4957	zinc ion binding
A6768_RS24965	COG2205	protein histidine kinase activity
A6768_RS24970	COG5001	Diguanylate cyclase
A6768_RS24980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6768_RS24990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6768_RS25005	COG1045	serine acetyltransferase
A6768_RS25010	COG0297	glycogen (starch) synthase activity
A6768_RS25010	COG0438	transferase activity, transferring glycosyl groups
A6768_RS25020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6768_RS25035	COG1968	undecaprenyl-diphosphatase activity
A6768_RS25060	COG2099	Precorrin-6x reductase
A6768_RS25075	COG2875	Belongs to the precorrin methyltransferase family
A6768_RS25080	COG1797	cobyrinic acid a,c-diamide synthase activity
A6768_RS25105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6768_RS25130	COG2205	protein histidine kinase activity
A6768_RS25150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6768_RS25170	COG3609	addiction module antidote protein, CC2985 family
A6768_RS25175	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A6768_RS25180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6768_RS25200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6768_RS25215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6768_RS25235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6768_RS25240	COG0217	transcriptional regulatory protein
A6768_RS25245	COG0393	Putative heavy-metal-binding
A6768_RS25255	COG3750	Belongs to the UPF0335 family
A6768_RS25265	COG0469	pyruvate kinase activity
A6768_RS25270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6768_RS25280	COG2866	Carboxypeptidase
A6768_RS25295	COG2264	protein methyltransferase activity
A6768_RS25340	COG0443	Heat shock 70 kDa protein
A6768_RS25345	COG0484	heat shock protein binding
A6768_RS25350	COG0531	amino acid
A6768_RS25360	COG1960	acyl-CoA dehydrogenase activity
A6768_RS25370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6768_RS25375	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6768_RS25380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6768_RS25390	COG0297	glycogen (starch) synthase activity
A6768_RS25390	COG0438	transferase activity, transferring glycosyl groups
A6768_RS25400	COG1024	Enoyl-CoA hydratase
A6768_RS25405	COG2207	Transcriptional regulator
A6768_RS25410	COG4638	Rieske (2fe-2S)
A6768_RS25440	COG1053	succinate dehydrogenase
A6768_RS25445	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS25455	COG2226	methyltransferase
A6768_RS25460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6768_RS25465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6768_RS25480	COG4638	Rieske (2fe-2S)
A6768_RS25495	COG2124	cytochrome p450
A6768_RS25500	COG1028	Short-chain dehydrogenase reductase Sdr
A6768_RS25515	COG2365	Tyrosine phosphatase family
A6768_RS25520	COG1012	belongs to the aldehyde dehydrogenase family
A6768_RS25605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6768_RS25615	COG2076	Multidrug Resistance protein
A6768_RS25625	COG2827	Endonuclease containing a URI domain
A6768_RS25630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6768_RS25635	COG4773	Receptor
A6768_RS25640	COG2885	chlorophyll binding
A6768_RS25645	COG0488	(ABC) transporter
A6768_RS25650	COG0628	permease
A6768_RS25700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6768_RS25720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6768_RS25730	COG0756	dUTP diphosphatase activity
A6768_RS25735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6768_RS25740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6768_RS25745	COG2226	methyltransferase
A6768_RS25750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6768_RS25755	COG0268	Binds directly to 16S ribosomal RNA
A6768_RS25760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids