locus-tag	class	description
H9L13_RS00015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L13_RS00015	COG1372	Participates in initiation and elongation during chromosome replication
H9L13_RS00020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9L13_RS00110	COG0308	aminopeptidase N
H9L13_RS00125	COG1127	ABC transporter
H9L13_RS00130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L13_RS00175	COG1496	oxidoreductase activity
H9L13_RS00190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9L13_RS00195	COG0318	PFAM AMP-dependent synthetase and ligase
H9L13_RS00200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9L13_RS00205	COG1028	Short-chain dehydrogenase reductase Sdr
H9L13_RS00250	COG4935	Belongs to the peptidase S8 family
H9L13_RS00250	COG1404	Belongs to the peptidase S8 family
H9L13_RS00260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9L13_RS00265	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9L13_RS00280	COG0697	spore germination
H9L13_RS00300	COG0006	proline dipeptidase activity
H9L13_RS00315	COG0625	glutathione transferase activity
H9L13_RS00320	COG0235	Class ii aldolase
H9L13_RS00325	COG1304	FMN binding
H9L13_RS00350	COG0542	response to heat
H9L13_RS00380	COG1570	exodeoxyribonuclease VII activity
H9L13_RS00385	COG0151	Belongs to the GarS family
H9L13_RS00400	COG1253	flavin adenine dinucleotide binding
H9L13_RS00410	COG0590	tRNA wobble adenosine to inosine editing
H9L13_RS00420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L13_RS00440	COG1733	regulation of RNA biosynthetic process
H9L13_RS00450	COG5507	3-demethylubiquinone-9 3-methyltransferase
H9L13_RS00490	COG1741	Belongs to the pirin family
H9L13_RS00495	COG0596	Alpha beta hydrolase
H9L13_RS00500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L13_RS00510	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H9L13_RS00520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L13_RS00525	COG0424	maF-like protein
H9L13_RS00535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H9L13_RS00605	COG2086	electron transfer activity
H9L13_RS00610	COG0045	succinate-CoA ligase (ADP-forming) activity
H9L13_RS00645	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H9L13_RS00660	COG2239	Acts as a magnesium transporter
H9L13_RS00665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L13_RS00670	COG4221	oxidoreductase activity
H9L13_RS00695	COG1758	RNA polymerase activity
H9L13_RS00700	COG1733	regulation of RNA biosynthetic process
H9L13_RS00710	COG0281	malic enzyme
H9L13_RS00710	COG0280	phosphate acetyltransferase
H9L13_RS00715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9L13_RS00735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L13_RS00740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L13_RS00770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L13_RS00780	COG1022	Amp-dependent synthetase and ligase
H9L13_RS00785	COG0405	Gamma-glutamyltransferase
H9L13_RS00790	COG0167	dihydroorotate dehydrogenase activity
H9L13_RS00800	COG0719	Fe-S assembly protein
H9L13_RS00810	COG0396	ATPase activity
H9L13_RS00820	COG0719	Fe-S assembly protein
H9L13_RS00825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L13_RS00830	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L13_RS00835	COG0316	Belongs to the HesB IscA family
H9L13_RS00855	COG2171	N-acyltransferase activity
H9L13_RS00865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L13_RS00875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H9L13_RS00880	COG0745	RESPONSE REGULATOR receiver
H9L13_RS00890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L13_RS00905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L13_RS00920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L13_RS00930	COG2095	MarC family integral membrane protein
H9L13_RS00950	COG0463	Glycosyl transferase, family 2
H9L13_RS00970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L13_RS00975	COG1215	transferase activity, transferring glycosyl groups
H9L13_RS00990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L13_RS01000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9L13_RS01025	COG1215	transferase activity, transferring glycosyl groups
H9L13_RS01085	COG0739	heme binding
H9L13_RS01095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L13_RS01100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9L13_RS01115	COG0175	sulfate reduction
H9L13_RS01135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9L13_RS01180	COG1671	Belongs to the UPF0178 family
H9L13_RS01210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9L13_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
H9L13_RS01250	COG5265	(ABC) transporter
H9L13_RS01270	COG0312	modulator of DNA gyrase
H9L13_RS01290	COG1131	(ABC) transporter
H9L13_RS01305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L13_RS01315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L13_RS01315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L13_RS01325	COG0138	bifunctional purine biosynthesis protein purh
H9L13_RS01340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L13_RS01340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L13_RS01350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9L13_RS01360	COG0181	hydroxymethylbilane synthase activity
H9L13_RS01385	COG0730	response to heat
H9L13_RS01400	COG3118	belongs to the thioredoxin family
H9L13_RS01410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L13_RS01435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L13_RS01435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L13_RS01460	COG0495	leucyl-tRNA aminoacylation
H9L13_RS01485	COG0357	Ribosomal RNA small subunit methyltransferase G
H9L13_RS01490	COG0445	tRNA wobble uridine modification
H9L13_RS01495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9L13_RS01500	COG0861	Integral membrane protein TerC family
H9L13_RS01505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H9L13_RS01510	COG1981	membrane
H9L13_RS01520	COG0424	maF-like protein
H9L13_RS01525	COG0237	dephospho-CoA kinase activity
H9L13_RS01530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L13_RS01535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9L13_RS01540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L13_RS01565	COG2983	Belongs to the UPF0260 family
H9L13_RS01575	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9L13_RS01580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L13_RS01640	COG0204	Acyl-transferase
H9L13_RS01645	COG0072	phenylalanine-tRNA ligase activity
H9L13_RS01650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L13_RS01665	COG2224	Isocitrate lyase
H9L13_RS01675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9L13_RS01685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L13_RS01690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L13_RS01720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L13_RS01735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9L13_RS01735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9L13_RS01745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L13_RS01745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L13_RS01750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9L13_RS01805	COG3483	tryptophan 2,3-dioxygenase activity
H9L13_RS01825	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H9L13_RS01845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L13_RS01850	COG0513	Belongs to the DEAD box helicase family
H9L13_RS01870	COG1137	ATPase activity
H9L13_RS01890	COG1278	Cold shock
H9L13_RS01895	COG1793	dna ligase
H9L13_RS01900	COG4294	response to UV
H9L13_RS01915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L13_RS01930	COG4221	oxidoreductase activity
H9L13_RS01940	COG0584	glycerophosphoryl diester phosphodiesterase
H9L13_RS01965	COG2319	Wd-40 repeat
H9L13_RS01970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9L13_RS01980	COG2076	Multidrug Resistance protein
H9L13_RS01990	COG0124	histidyl-tRNA synthetase
H9L13_RS01995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L13_RS02000	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L13_RS02020	COG1607	acyl-coa hydrolase
H9L13_RS02030	COG0517	IMP dehydrogenase activity
H9L13_RS02075	COG0501	Belongs to the peptidase M48B family
H9L13_RS02090	COG0189	ligase activity
H9L13_RS02095	COG1793	dna ligase
H9L13_RS02105	COG0010	Belongs to the arginase family
H9L13_RS02110	COG1228	amidohydrolase
H9L13_RS02120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9L13_RS02135	COG2986	histidine ammonia-lyase
H9L13_RS02175	COG0596	Alpha beta hydrolase
H9L13_RS02180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L13_RS02185	COG2354	Protein conserved in bacteria
H9L13_RS02215	COG0183	Belongs to the thiolase family
H9L13_RS02220	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L13_RS02225	COG4948	Mandelate Racemase Muconate Lactonizing
H9L13_RS02230	COG2723	6-phospho-beta-galactosidase activity
H9L13_RS02240	COG3734	2-keto-3-deoxy-galactonokinase
H9L13_RS02245	COG0800	Aldolase
H9L13_RS02260	COG0418	dihydroorotase activity
H9L13_RS02320	COG0114	fumarate hydratase activity
H9L13_RS02335	COG0531	amino acid
H9L13_RS02340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L13_RS02350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9L13_RS02355	COG4152	abc transporter atp-binding protein
H9L13_RS02380	COG0573	inorganic phosphate transmembrane transporter activity
H9L13_RS02385	COG0581	inorganic phosphate transmembrane transporter activity
H9L13_RS02390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9L13_RS02395	COG0704	Plays a role in the regulation of phosphate uptake
H9L13_RS02400	COG0745	RESPONSE REGULATOR receiver
H9L13_RS02405	COG1392	Phosphate transport regulator
H9L13_RS02410	COG0306	phosphate transporter
H9L13_RS02425	COG5002	protein histidine kinase activity
H9L13_RS02450	COG3279	Response regulator of the LytR AlgR family
H9L13_RS02455	COG3275	phosphorelay sensor kinase activity
H9L13_RS02470	COG5001	Diguanylate cyclase
H9L13_RS02470	COG3300	MHYT domain
H9L13_RS02475	COG5001	Diguanylate cyclase
H9L13_RS02490	COG4585	Histidine kinase
H9L13_RS02515	COG3657	addiction module killer protein
H9L13_RS02540	COG0481	GTPase activity
H9L13_RS02550	COG0612	Peptidase, M16
H9L13_RS02555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9L13_RS02570	COG0588	phosphoglycerate mutase activity
H9L13_RS02575	COG2866	Carboxypeptidase
H9L13_RS02580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L13_RS02590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9L13_RS02605	COG3655	Transcriptional regulator
H9L13_RS02625	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9L13_RS02650	COG2989	Protein conserved in bacteria
H9L13_RS02660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9L13_RS02665	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L13_RS02675	COG0681	Belongs to the peptidase S26 family
H9L13_RS02680	COG0736	holo-[acyl-carrier-protein] synthase activity
H9L13_RS02690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9L13_RS02705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9L13_RS02710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9L13_RS02715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9L13_RS02735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L13_RS02745	COG0109	protoheme IX farnesyltransferase activity
H9L13_RS02780	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L13_RS02785	COG4133	protoheme IX ABC transporter activity
H9L13_RS02805	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H9L13_RS02810	COG1595	DNA-templated transcription, initiation
H9L13_RS02875	COG0582	viral genome integration into host DNA
H9L13_RS02880	COG0069	glutamate synthase activity
H9L13_RS02885	COG0484	heat shock protein binding
H9L13_RS02935	COG2885	chlorophyll binding
H9L13_RS02935	COG3047	cAMP biosynthetic process
H9L13_RS02970	COG4206	TonB-dependent receptor
H9L13_RS03000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9L13_RS03005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9L13_RS03010	COG1845	cytochrome c oxidase, subunit III
H9L13_RS03015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9L13_RS03085	COG4964	Belongs to the GSP D family
H9L13_RS03115	COG0739	heme binding
H9L13_RS03130	COG2080	2 iron, 2 sulfur cluster binding
H9L13_RS03180	COG0776	regulation of translation
H9L13_RS03185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L13_RS03190	COG0416	fatty acid biosynthetic process
H9L13_RS03195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L13_RS03205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L13_RS03240	COG1201	RNA secondary structure unwinding
H9L13_RS03255	COG3920	Histidine kinase
H9L13_RS03260	COG0784	Response regulator, receiver
H9L13_RS03295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9L13_RS03310	COG0823	Involved in the tonB-independent uptake of proteins
H9L13_RS03315	COG0824	Thioesterase
H9L13_RS03325	COG2255	four-way junction helicase activity
H9L13_RS03335	COG0632	four-way junction helicase activity
H9L13_RS03340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9L13_RS03345	COG0217	transcriptional regulatory protein
H9L13_RS03350	COG3750	Belongs to the UPF0335 family
H9L13_RS03355	COG0222	ribosome binding
H9L13_RS03360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9L13_RS03370	COG0081	regulation of translation
H9L13_RS03375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L13_RS03405	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9L13_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
H9L13_RS03425	COG0318	PFAM AMP-dependent synthetase and ligase
H9L13_RS03435	COG1278	Cold shock
H9L13_RS03455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9L13_RS03480	COG0598	Magnesium transport protein CorA
H9L13_RS03485	COG0439	Biotin carboxylase
H9L13_RS03490	COG0511	ligase activity, forming carbon-carbon bonds
H9L13_RS03500	COG2022	thiamine diphosphate biosynthetic process
H9L13_RS03505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9L13_RS03555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H9L13_RS03575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L13_RS03595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9L13_RS03600	COG0297	glycogen (starch) synthase activity
H9L13_RS03620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9L13_RS03650	COG4166	transmembrane transport
H9L13_RS03670	COG0745	RESPONSE REGULATOR receiver
H9L13_RS03685	COG2205	protein histidine kinase activity
H9L13_RS03685	COG3437	response regulator, receiver
H9L13_RS03685	COG3850	Histidine kinase
H9L13_RS03685	COG4999	Histidine kinase
H9L13_RS03690	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H9L13_RS03695	COG4191	Histidine kinase
H9L13_RS03695	COG0784	Response regulator, receiver
H9L13_RS03710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L13_RS03720	COG5001	Diguanylate cyclase
H9L13_RS03720	COG3300	MHYT domain
H9L13_RS03730	COG3655	Transcriptional regulator
H9L13_RS03740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L13_RS03750	COG1968	undecaprenyl-diphosphatase activity
H9L13_RS03765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L13_RS03805	COG0037	tRNA processing
H9L13_RS03830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L13_RS03835	COG0799	negative regulation of ribosome biogenesis
H9L13_RS03845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9L13_RS03860	COG0793	Belongs to the peptidase S41A family
H9L13_RS03870	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H9L13_RS03900	COG1573	uracil-dna glycosylase
H9L13_RS03905	COG4774	siderophore transport
H9L13_RS03910	COG2124	cytochrome p450
H9L13_RS03940	COG3474	cytochrome
H9L13_RS03945	COG1611	Belongs to the LOG family
H9L13_RS03975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L13_RS04005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H9L13_RS04015	COG3920	Histidine kinase
H9L13_RS04050	COG0312	modulator of DNA gyrase
H9L13_RS04055	COG1832	CoA-binding protein
H9L13_RS04060	COG0489	protein tyrosine kinase activity
H9L13_RS04065	COG0330	HflC and HflK could
H9L13_RS04080	COG0433	COG0433 Predicted ATPase
H9L13_RS04090	COG1297	OPT oligopeptide transporter protein
H9L13_RS04095	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9L13_RS04100	COG2897	thiosulfate sulfurtransferase activity
H9L13_RS04110	COG0745	RESPONSE REGULATOR receiver
H9L13_RS04120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9L13_RS04130	COG0196	riboflavin kinase activity
H9L13_RS04135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L13_RS04140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9L13_RS04145	COG0202	RNA polymerase activity
H9L13_RS04200	COG0156	8-amino-7-oxononanoate synthase activity
H9L13_RS04210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9L13_RS04215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L13_RS04220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9L13_RS04245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L13_RS04250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L13_RS04275	COG0135	phosphoribosylanthranilate isomerase activity
H9L13_RS04275	COG0134	indole-3-glycerol-phosphate synthase activity
H9L13_RS04295	COG4181	ATPase activity
H9L13_RS04305	COG1138	Cytochrome C-type biogenesis protein
H9L13_RS04310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L13_RS04390	COG0363	glucosamine-6-phosphate deaminase activity
H9L13_RS04410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9L13_RS04415	COG1064	alcohol dehydrogenase
H9L13_RS04420	COG2301	Belongs to the HpcH HpaI aldolase family
H9L13_RS04425	COG2030	dehydratase
H9L13_RS04430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9L13_RS04435	COG2311	Membrane
H9L13_RS04445	COG0625	glutathione transferase activity
H9L13_RS04465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L13_RS04470	COG0085	RNA polymerase activity
H9L13_RS04480	COG0596	Alpha beta hydrolase
H9L13_RS04480	COG2945	thiolester hydrolase activity
H9L13_RS04485	COG0469	pyruvate kinase activity
H9L13_RS04490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9L13_RS04535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L13_RS04545	COG0346	lactoylglutathione lyase activity
H9L13_RS04550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L13_RS04550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L13_RS04565	COG3920	Histidine kinase
H9L13_RS04570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9L13_RS04585	COG1024	Enoyl-CoA hydratase
H9L13_RS04605	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H9L13_RS04610	COG3174	membrane
H9L13_RS04640	COG3402	PFAM membrane-flanked domain
H9L13_RS04645	COG1494	fructose-1,6-bisphosphatase
H9L13_RS04675	COG1473	amidohydrolase
H9L13_RS04680	COG0556	nucleotide-excision repair
H9L13_RS04705	COG2197	response regulator
H9L13_RS04730	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H9L13_RS04765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9L13_RS04780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9L13_RS04795	COG1862	Preprotein translocase
H9L13_RS04800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L13_RS04805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L13_RS04810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L13_RS04830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L13_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
H9L13_RS04905	COG0471	metal ion transport
H9L13_RS04905	COG3273	potassium ion transport
H9L13_RS04910	COG0539	negative regulation of cytoplasmic translation
H9L13_RS04915	COG0776	regulation of translation
H9L13_RS04935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L13_RS04940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L13_RS04945	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9L13_RS04950	COG0583	DNA-binding transcription factor activity
H9L13_RS04955	COG0730	response to heat
H9L13_RS04960	COG1045	serine acetyltransferase
H9L13_RS04980	COG0113	porphobilinogen synthase activity
H9L13_RS05075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L13_RS05095	COG3724	N-succinylarginine dihydrolase activity
H9L13_RS05100	COG3138	arginine N-succinyltransferase
H9L13_RS05110	COG1051	belongs to the nudix hydrolase family
H9L13_RS05120	COG0674	pyruvate-flavodoxin oxidoreductase activity
H9L13_RS05120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H9L13_RS05125	COG1013	pyruvate-flavodoxin oxidoreductase activity
H9L13_RS05135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L13_RS05145	COG4221	oxidoreductase activity
H9L13_RS05160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9L13_RS05165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L13_RS05175	COG1960	acyl-CoA dehydrogenase activity
H9L13_RS05195	COG5001	Diguanylate cyclase
H9L13_RS05210	COG2267	carboxylic ester hydrolase activity
H9L13_RS05220	COG2050	protein possibly involved in aromatic compounds catabolism
H9L13_RS05240	COG0215	cysteine-tRNA ligase activity
H9L13_RS05250	COG0475	glutathione-regulated potassium exporter activity
H9L13_RS05250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9L13_RS05265	COG4974	Belongs to the 'phage' integrase family
H9L13_RS05270	COG0825	malonyl-CoA metabolic process
H9L13_RS05275	COG4783	chaperone-mediated protein folding
H9L13_RS05285	COG2226	methyltransferase
H9L13_RS05290	COG1040	competence protein
H9L13_RS05295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L13_RS05300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L13_RS05325	COG0302	gtp cyclohydrolase
H9L13_RS05340	COG1301	dicarboxylic acid transport
H9L13_RS05355	COG3275	phosphorelay sensor kinase activity
H9L13_RS05380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L13_RS05385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H9L13_RS05425	COG1970	mechanosensitive ion channel activity
H9L13_RS05430	COG1704	LemA family
H9L13_RS05435	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H9L13_RS05445	COG0494	nUDIX hydrolase
H9L13_RS05475	COG0251	oxidation-reduction process
H9L13_RS05480	COG0183	Belongs to the thiolase family
H9L13_RS05485	COG1960	acyl-CoA dehydrogenase activity
H9L13_RS05505	COG4770	biotin carboxylase activity
H9L13_RS05510	COG2032	superoxide dismutase activity
H9L13_RS05560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L13_RS05575	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H9L13_RS05605	COG0670	Belongs to the BI1 family
H9L13_RS05655	COG0604	alcohol dehydrogenase
H9L13_RS05665	COG1722	exodeoxyribonuclease VII activity
H9L13_RS05670	COG0142	geranyltranstransferase activity
H9L13_RS05675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9L13_RS05685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9L13_RS05695	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H9L13_RS05705	COG0343	queuine tRNA-ribosyltransferase activity
H9L13_RS05710	COG0625	glutathione transferase activity
H9L13_RS05715	COG0513	Belongs to the DEAD box helicase family
H9L13_RS05750	COG3665	Urea carboxylase-associated protein
H9L13_RS05780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9L13_RS05790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L13_RS05795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L13_RS05800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L13_RS05805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L13_RS05810	COG0454	-acetyltransferase
H9L13_RS05815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L13_RS05815	COG2169	Transcriptional regulator
H9L13_RS05820	COG1266	CAAX protease self-immunity
H9L13_RS05830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L13_RS05850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L13_RS05855	COG5001	Diguanylate cyclase
H9L13_RS05865	COG4566	intracellular signal transduction
H9L13_RS05870	COG0617	tRNA 3'-terminal CCA addition
H9L13_RS05885	COG1028	Short-chain dehydrogenase reductase Sdr
H9L13_RS05915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9L13_RS05930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L13_RS05940	COG0583	DNA-binding transcription factor activity
H9L13_RS05960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9L13_RS05965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9L13_RS05975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9L13_RS05985	COG0571	ribonuclease III activity
H9L13_RS05990	COG0681	Belongs to the peptidase S26 family
H9L13_RS05995	COG0166	Belongs to the GPI family
H9L13_RS06010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9L13_RS06035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L13_RS06065	COG1024	Enoyl-CoA hydratase
H9L13_RS06070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9L13_RS06085	COG4974	Belongs to the 'phage' integrase family
H9L13_RS06090	COG0586	Pfam SNARE associated Golgi protein
H9L13_RS06095	COG0189	ligase activity
H9L13_RS06100	COG0792	nuclease activity
H9L13_RS06105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9L13_RS06115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L13_RS06120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L13_RS06125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9L13_RS06130	COG1420	regulation of RNA biosynthetic process
H9L13_RS06135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L13_RS06160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L13_RS06165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L13_RS06170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9L13_RS06190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L13_RS06195	COG0723	plastoquinol--plastocyanin reductase activity
H9L13_RS06205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9L13_RS06205	COG2857	Cytochrome c1
H9L13_RS06215	COG2030	dehydratase
H9L13_RS06215	COG1012	belongs to the aldehyde dehydrogenase family
H9L13_RS06220	COG0457	Tetratricopeptide repeat
H9L13_RS06230	COG0671	phosphoesterase, PA-phosphatase related
H9L13_RS06235	COG0012	GTP binding
H9L13_RS06255	COG0193	aminoacyl-tRNA hydrolase activity
H9L13_RS06260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9L13_RS06275	COG0752	glycyl-tRNA synthetase alpha subunit
H9L13_RS06280	COG0751	glycine-tRNA ligase activity
H9L13_RS06310	COG4964	Belongs to the GSP D family
H9L13_RS06335	COG0328	RNA-DNA hybrid ribonuclease activity
H9L13_RS06340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9L13_RS06350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9L13_RS06355	COG0509	glycine decarboxylation via glycine cleavage system
H9L13_RS06360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L13_RS06365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L13_RS06370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L13_RS06425	COG2264	protein methyltransferase activity
H9L13_RS06435	COG0367	asparagine synthase
H9L13_RS06440	COG1132	(ABC) transporter
H9L13_RS06460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H9L13_RS06465	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H9L13_RS06470	COG1088	dTDP-glucose 4,6-dehydratase activity
H9L13_RS06475	COG1091	dTDP-4-dehydrorhamnose reductase activity
H9L13_RS06510	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H9L13_RS06520	COG2226	methyltransferase
H9L13_RS06530	COG1215	transferase activity, transferring glycosyl groups
H9L13_RS06545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L13_RS06565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9L13_RS06590	COG1454	alcohol dehydrogenase
H9L13_RS06630	COG1538	Outer membrane efflux protein
H9L13_RS06635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9L13_RS06640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L13_RS06655	COG1562	ergosterol biosynthetic process
H9L13_RS06680	COG2197	response regulator
H9L13_RS06695	COG4232	protein-disulfide reductase activity
H9L13_RS06715	COG2132	Multicopper oxidase
H9L13_RS06745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9L13_RS06745	COG0131	Imidazoleglycerol-phosphate dehydratase
H9L13_RS06755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9L13_RS06765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9L13_RS06765	COG0140	phosphoribosyl-ATP diphosphatase activity
H9L13_RS06770	COG0483	inositol monophosphate 1-phosphatase activity
H9L13_RS06775	COG0582	viral genome integration into host DNA
H9L13_RS06800	COG4983	Phage plasmid primase, P4 family domain protein
H9L13_RS06815	COG1401	restriction endodeoxyribonuclease activity
H9L13_RS06820	COG4268	DNA restriction-modification system
H9L13_RS06890	COG0772	Belongs to the SEDS family
H9L13_RS06895	COG0768	penicillin binding
H9L13_RS06920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9L13_RS06930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9L13_RS06940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9L13_RS06950	COG0560	Phosphoserine phosphatase
H9L13_RS06975	COG0540	Belongs to the ATCase OTCase family
H9L13_RS06980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L13_RS06995	COG1285	pathogenesis
H9L13_RS07000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L13_RS07005	COG0154	amidase activity
H9L13_RS07010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L13_RS07025	COG0501	Belongs to the peptidase M48B family
H9L13_RS07045	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L13_RS07055	COG0740	serine-type endopeptidase activity
H9L13_RS07075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9L13_RS07080	COG2814	Major facilitator Superfamily
H9L13_RS07090	COG0010	Belongs to the arginase family
H9L13_RS07095	COG1301	dicarboxylic acid transport
H9L13_RS07115	COG2244	polysaccharide biosynthetic process
H9L13_RS07120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L13_RS07130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L13_RS07135	COG0564	pseudouridine synthase activity
H9L13_RS07145	COG0643	Histidine kinase
H9L13_RS07145	COG2198	Histidine kinase
H9L13_RS07155	COG0745	RESPONSE REGULATOR receiver
H9L13_RS07160	COG2201	protein-glutamate methylesterase activity
H9L13_RS07165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9L13_RS07170	COG3023	N-Acetylmuramoyl-L-alanine amidase
H9L13_RS07185	COG2166	iron-sulfur cluster assembly
H9L13_RS07220	COG1842	Phage shock protein A
H9L13_RS07225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9L13_RS07240	COG0842	Transport permease protein
H9L13_RS07245	COG1131	(ABC) transporter
H9L13_RS07250	COG2917	probably involved in intracellular septation
H9L13_RS07255	COG0552	protein localization to endoplasmic reticulum
H9L13_RS07260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L13_RS07265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9L13_RS07275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9L13_RS07280	COG0228	four-way junction DNA binding
H9L13_RS07285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L13_RS07290	COG0492	ferredoxin-NADP+ reductase activity
H9L13_RS07300	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L13_RS07305	COG0335	large ribosomal subunit rRNA binding
H9L13_RS07330	COG3128	pkhd-type hydroxylase
H9L13_RS07340	COG2989	Protein conserved in bacteria
H9L13_RS07345	COG2267	carboxylic ester hydrolase activity
H9L13_RS07360	COG0678	peroxiredoxin activity
H9L13_RS07360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L13_RS07365	COG1678	Uncharacterized ACR, COG1678
H9L13_RS07370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H9L13_RS07375	COG2205	protein histidine kinase activity
H9L13_RS07380	COG0802	atpase or kinase
H9L13_RS07390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9L13_RS07395	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H9L13_RS07405	COG1074	ATP-dependent DNA helicase activity
H9L13_RS07415	COG0653	protein targeting
H9L13_RS07435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9L13_RS07440	COG5001	Diguanylate cyclase
H9L13_RS07440	COG3300	MHYT domain
H9L13_RS07445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9L13_RS07450	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H9L13_RS07455	COG2311	Membrane
H9L13_RS07460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9L13_RS07465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9L13_RS07475	COG3876	Protein conserved in bacteria
H9L13_RS07505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H9L13_RS07510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L13_RS07525	COG1278	Cold shock
H9L13_RS07545	COG3360	Dodecin
H9L13_RS07570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L13_RS07575	COG0358	DNA primase activity
H9L13_RS07590	COG0505	Belongs to the CarA family
H9L13_RS07600	COG2852	Protein conserved in bacteria
H9L13_RS07610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L13_RS07650	COG0148	phosphopyruvate hydratase activity
H9L13_RS07660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9L13_RS07665	COG0022	dehydrogenase e1 component
H9L13_RS07665	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L13_RS07690	COG2200	EAL domain
H9L13_RS07695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H9L13_RS07735	COG2205	protein histidine kinase activity
H9L13_RS07830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9L13_RS07835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9L13_RS07835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9L13_RS07840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L13_RS07850	COG1228	amidohydrolase
H9L13_RS07905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L13_RS07910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9L13_RS07945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9L13_RS07960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9L13_RS07960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9L13_RS07975	COG5000	phosphorelay sensor kinase activity
H9L13_RS07980	COG2204	response regulator
H9L13_RS07985	COG1923	regulation of RNA biosynthetic process
H9L13_RS07990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L13_RS07995	COG3956	TIGRFAM MazG family protein
H9L13_RS08005	COG0321	lipoyl(octanoyl) transferase activity
H9L13_RS08005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9L13_RS08010	COG0084	hydrolase, TatD family'
H9L13_RS08025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9L13_RS08030	COG1686	Belongs to the peptidase S11 family
H9L13_RS08035	COG2951	lytic endotransglycosylase activity
H9L13_RS08080	COG1960	acyl-CoA dehydrogenase activity
H9L13_RS08090	COG1704	LemA family
H9L13_RS08105	COG0254	rRNA binding
H9L13_RS08120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9L13_RS08130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L13_RS08135	COG0750	zinc metalloprotease
H9L13_RS08140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9L13_RS08150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L13_RS08155	COG0233	cytoplasmic translational termination
H9L13_RS08160	COG0528	UMP kinase activity
H9L13_RS08170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L13_RS08175	COG0052	Belongs to the universal ribosomal protein uS2 family
H9L13_RS08180	COG1183	phosphatidylcholine synthase activity
H9L13_RS08185	COG0688	phosphatidylethanolamine metabolic process
H9L13_RS08190	COG0538	isocitrate dehydrogenase activity
H9L13_RS08205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9L13_RS08205	COG0475	glutathione-regulated potassium exporter activity
H9L13_RS08245	COG1136	(ABC) transporter
H9L13_RS08255	COG0442	prolyl-tRNA aminoacylation
H9L13_RS08270	COG0626	cystathionine gamma-synthase activity
H9L13_RS08320	COG3158	transport of potassium into the cell
H9L13_RS08325	COG0686	Belongs to the AlaDH PNT family
H9L13_RS08330	COG4235	cytochrome complex assembly
H9L13_RS08340	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H9L13_RS08350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L13_RS08355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9L13_RS08400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9L13_RS08410	COG0784	Response regulator, receiver
H9L13_RS08425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L13_RS08430	COG0741	lytic transglycosylase activity
H9L13_RS08440	COG2326	polyphosphate kinase activity
H9L13_RS08445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L13_RS08450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H9L13_RS08470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L13_RS08485	COG0105	UTP biosynthetic process
H9L13_RS08495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L13_RS08530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L13_RS08530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L13_RS08540	COG2301	Belongs to the HpcH HpaI aldolase family
H9L13_RS08545	COG0330	HflC and HflK could
H9L13_RS08580	COG0745	RESPONSE REGULATOR receiver
H9L13_RS08590	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H9L13_RS08595	COG1660	Displays ATPase and GTPase activities
H9L13_RS08600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L13_RS08600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L13_RS08610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L13_RS08625	COG1322	Protein conserved in bacteria
H9L13_RS08635	COG0242	peptide deformylase activity
H9L13_RS08640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L13_RS08645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9L13_RS08650	COG0101	tRNA pseudouridine synthase activity
H9L13_RS08655	COG0492	ferredoxin-NADP+ reductase activity
H9L13_RS08660	COG0504	CTP synthase activity
H9L13_RS08670	COG0149	triose-phosphate isomerase activity
H9L13_RS08680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L13_RS08695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L13_RS08700	COG0372	Belongs to the citrate synthase family
H9L13_RS08705	COG2205	protein histidine kinase activity
H9L13_RS08735	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H9L13_RS08760	COG0713	ATP synthesis coupled electron transport
H9L13_RS08770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L13_RS08775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9L13_RS08780	COG1034	ATP synthesis coupled electron transport
H9L13_RS08815	COG0649	NAD binding
H9L13_RS08820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L13_RS08825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L13_RS08830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L13_RS08835	COG0483	inositol monophosphate 1-phosphatase activity
H9L13_RS08840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L13_RS08845	COG0739	heme binding
H9L13_RS08850	COG1376	ErfK ybiS ycfS ynhG family protein
H9L13_RS08855	COG0352	thiamine-phosphate diphosphorylase activity
H9L13_RS08865	COG3588	fructose-bisphosphate aldolase
H9L13_RS08870	COG0126	phosphoglycerate kinase activity
H9L13_RS08875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9L13_RS08900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9L13_RS08915	COG0484	heat shock protein binding
H9L13_RS08935	COG0602	queuosine metabolic process
H9L13_RS08960	COG0594	ribonuclease P activity
H9L13_RS08965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9L13_RS08970	COG0706	membrane insertase activity
H9L13_RS08975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9L13_RS08980	COG0625	glutathione transferase activity
H9L13_RS08995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L13_RS09005	COG5001	Diguanylate cyclase
H9L13_RS09005	COG3300	MHYT domain
H9L13_RS09030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9L13_RS09035	COG0728	peptidoglycan biosynthetic process
H9L13_RS09040	COG0180	Tryptophanyl-tRNA synthetase
H9L13_RS09045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9L13_RS09050	COG0268	Binds directly to 16S ribosomal RNA
H9L13_RS09055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L13_RS09060	COG2226	methyltransferase
H9L13_RS09090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9L13_RS09095	COG0756	dUTP diphosphatase activity
H9L13_RS09100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9L13_RS09100	COG1754	DNA topoisomerase type I activity
H9L13_RS09125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9L13_RS09130	COG0156	8-amino-7-oxononanoate synthase activity
H9L13_RS09135	COG0698	ribose 5-phosphate isomerase
H9L13_RS09140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L13_RS09145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L13_RS09160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L13_RS09175	COG1573	uracil-dna glycosylase
H9L13_RS09180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9L13_RS09200	COG0489	protein tyrosine kinase activity
H9L13_RS09210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9L13_RS09215	COG2967	ApaG domain
H9L13_RS09220	COG1381	Involved in DNA repair and RecF pathway recombination
H9L13_RS09225	COG0322	excinuclease ABC activity
H9L13_RS09230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L13_RS09255	COG5001	Diguanylate cyclase
H9L13_RS09255	COG4251	negative regulation of phosphorylation
H9L13_RS09255	COG3706	GGDEF domain
H9L13_RS09255	COG2203	Gaf domain
H9L13_RS09260	COG0432	Pfam Uncharacterised protein family UPF0047
H9L13_RS09265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9L13_RS09295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L13_RS09300	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H9L13_RS09305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L13_RS09310	COG0351	phosphomethylpyrimidine kinase
H9L13_RS09310	COG0352	thiamine-phosphate diphosphorylase activity
H9L13_RS09315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L13_RS09325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L13_RS09330	COG0402	S-adenosylhomocysteine deaminase activity
H9L13_RS09335	COG3104	oligopeptide transport
H9L13_RS09345	COG2188	Transcriptional regulator
H9L13_RS09350	COG0009	L-threonylcarbamoyladenylate synthase
H9L13_RS09355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L13_RS09365	COG0745	RESPONSE REGULATOR receiver
H9L13_RS09370	COG2203	Gaf domain
H9L13_RS09370	COG4251	negative regulation of phosphorylation
H9L13_RS09370	COG3706	GGDEF domain
H9L13_RS09370	COG5001	Diguanylate cyclase
H9L13_RS09375	COG1012	belongs to the aldehyde dehydrogenase family
H9L13_RS09385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L13_RS09385	COG0678	peroxiredoxin activity
H9L13_RS09420	COG5002	protein histidine kinase activity
H9L13_RS09435	COG0314	molybdopterin synthase activity
H9L13_RS09440	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9L13_RS09445	COG0315	cyclic pyranopterin monophosphate synthase activity
H9L13_RS09455	COG0746	molybdenum cofactor guanylyltransferase activity
H9L13_RS09460	COG0730	response to heat
H9L13_RS09470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L13_RS09495	COG2181	nitrate reductase activity
H9L13_RS09500	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H9L13_RS09510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H9L13_RS09515	COG2223	nitrite transmembrane transporter activity
H9L13_RS09520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9L13_RS09525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L13_RS09600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9L13_RS09615	COG1612	heme a metabolic process
H9L13_RS09620	COG1324	tolerance protein
H9L13_RS09635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9L13_RS09640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9L13_RS09645	COG1164	Oligoendopeptidase f
H9L13_RS09675	COG0024	Methionine aminopeptidase
H9L13_RS09690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9L13_RS09705	COG0408	coproporphyrinogen oxidase activity
H9L13_RS09720	COG0321	lipoyl(octanoyl) transferase activity
H9L13_RS09735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9L13_RS09750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9L13_RS09755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9L13_RS09765	COG0842	Transport permease protein
H9L13_RS09775	COG2267	carboxylic ester hydrolase activity
H9L13_RS09790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L13_RS09810	COG3920	Histidine kinase
H9L13_RS09815	COG2201	protein-glutamate methylesterase activity
H9L13_RS09820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L13_RS09820	COG0678	peroxiredoxin activity
H9L13_RS09830	COG0071	Belongs to the small heat shock protein (HSP20) family
H9L13_RS09840	COG0187	DNA topoisomerase II activity
H9L13_RS09855	COG1278	Cold shock
H9L13_RS09870	COG4771	TonB-dependent receptor
H9L13_RS09885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L13_RS09890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H9L13_RS09895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9L13_RS09900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L13_RS09915	COG0174	glutamine synthetase
H9L13_RS09930	COG0477	Major facilitator Superfamily
H9L13_RS09935	COG2852	Protein conserved in bacteria
H9L13_RS09940	COG0531	amino acid
H9L13_RS09975	COG0693	protein deglycase activity
H9L13_RS09985	COG0668	transmembrane transport
H9L13_RS09995	COG0183	Belongs to the thiolase family
H9L13_RS10010	COG0477	Major facilitator Superfamily
H9L13_RS10030	COG1132	(ABC) transporter
H9L13_RS10065	COG0784	Response regulator, receiver
H9L13_RS10080	COG0628	permease
H9L13_RS10090	COG0022	dehydrogenase e1 component
H9L13_RS10095	COG1448	Aminotransferase
H9L13_RS10100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9L13_RS10110	COG3460	Phenylacetate-CoA oxygenase
H9L13_RS10115	COG3396	Phenylacetate-CoA oxygenase
H9L13_RS10120	COG2050	protein possibly involved in aromatic compounds catabolism
H9L13_RS10125	COG1024	Enoyl-CoA hydratase
H9L13_RS10135	COG1960	acyl-CoA dehydrogenase activity
H9L13_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
H9L13_RS10145	COG1012	belongs to the aldehyde dehydrogenase family
H9L13_RS10145	COG2030	dehydratase
H9L13_RS10155	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H9L13_RS10160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L13_RS10165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L13_RS10170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L13_RS10175	COG0356	it plays a direct role in the translocation of protons across the membrane
H9L13_RS10200	COG2003	Belongs to the UPF0758 family
H9L13_RS10210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9L13_RS10220	COG0484	heat shock protein binding
H9L13_RS10225	COG0443	Heat shock 70 kDa protein
H9L13_RS10235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H9L13_RS10240	COG0531	amino acid
H9L13_RS10250	COG4638	Rieske (2fe-2S)
H9L13_RS10260	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L13_RS10265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L13_RS10270	COG0359	binds to the 23S rRNA
H9L13_RS10350	COG4695	Portal protein
H9L13_RS10405	COG0438	transferase activity, transferring glycosyl groups
H9L13_RS10445	COG0284	orotidine-5'-phosphate decarboxylase activity
H9L13_RS10450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9L13_RS10455	COG0285	dihydrofolate synthase activity
H9L13_RS10460	COG2223	nitrite transmembrane transporter activity
H9L13_RS10465	COG0784	Response regulator, receiver
H9L13_RS10465	COG2205	protein histidine kinase activity
H9L13_RS10470	COG1187	pseudouridine synthase activity
H9L13_RS10475	COG0742	ribosomal rna small subunit methyltransferase
H9L13_RS10485	COG0525	valine-tRNA ligase activity
H9L13_RS10500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9L13_RS10510	COG0165	Argininosuccinate lyase
H9L13_RS10520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L13_RS10525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9L13_RS10530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H9L13_RS10535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9L13_RS10540	COG1438	arginine binding
H9L13_RS10555	COG0577	efflux transmembrane transporter activity
H9L13_RS10555	COG1136	(ABC) transporter
H9L13_RS10560	COG0577	efflux transmembrane transporter activity
H9L13_RS10560	COG1136	(ABC) transporter
H9L13_RS10570	COG2204	response regulator
H9L13_RS10575	COG3852	Histidine kinase
H9L13_RS10585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9L13_RS10590	COG1012	belongs to the aldehyde dehydrogenase family
H9L13_RS10600	COG0717	Belongs to the dCTP deaminase family
H9L13_RS10610	COG2259	Doxx family
H9L13_RS10615	COG0431	NADPH-dependent FMN reductase
H9L13_RS10620	COG0557	exoribonuclease II activity
H9L13_RS10630	COG2852	Protein conserved in bacteria
H9L13_RS10635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9L13_RS10660	COG1960	acyl-CoA dehydrogenase activity
H9L13_RS10665	COG3243	poly(R)-hydroxyalkanoic acid synthase
H9L13_RS10670	COG1024	Enoyl-CoA hydratase
H9L13_RS10670	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L13_RS10705	COG4957	zinc ion binding
H9L13_RS10720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L13_RS10730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L13_RS10735	COG1253	flavin adenine dinucleotide binding
H9L13_RS10745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9L13_RS10750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L13_RS10765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9L13_RS10770	COG2133	pyrroloquinoline quinone binding
H9L13_RS10780	COG1755	Isoprenylcysteine carboxyl methyltransferase
H9L13_RS10790	COG0779	Required for maturation of 30S ribosomal subunits
H9L13_RS10805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9L13_RS10810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L13_RS10820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9L13_RS10825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9L13_RS10830	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L13_RS10910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L13_RS10965	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H9L13_RS10990	COG2226	methyltransferase
H9L13_RS11025	COG2130	NADP-dependent
H9L13_RS11030	COG2321	neutral zinc metallopeptidase
H9L13_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
H9L13_RS11050	COG0667	Aldo Keto reductase
H9L13_RS11055	COG2205	protein histidine kinase activity
H9L13_RS11060	COG2204	response regulator
H9L13_RS11080	COG0488	(ABC) transporter
H9L13_RS11100	COG0142	geranyltranstransferase activity
H9L13_RS11110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L13_RS11130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L13_RS11140	COG4206	TonB-dependent receptor
H9L13_RS11180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9L13_RS11185	COG0668	transmembrane transport
H9L13_RS11240	COG1842	Phage shock protein A
H9L13_RS11285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L13_RS11290	COG1733	regulation of RNA biosynthetic process
H9L13_RS11295	COG2003	Belongs to the UPF0758 family
H9L13_RS11315	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9L13_RS11315	COG1388	LysM domain
H9L13_RS11320	COG1530	ribonuclease E activity
H9L13_RS11335	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9L13_RS11390	COG1217	gtp-binding protein TYPA
H9L13_RS11420	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L13_RS11420	COG1024	Enoyl-CoA hydratase
H9L13_RS11435	COG1960	acyl-CoA dehydrogenase activity
H9L13_RS11445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L13_RS11450	COG0047	phosphoribosylformylglycinamidine synthase activity
H9L13_RS11470	COG0277	FAD linked oxidase domain protein
H9L13_RS11475	COG2226	methyltransferase
H9L13_RS11490	COG0563	adenylate kinase activity
H9L13_RS11495	COG0201	protein transport
H9L13_RS11500	COG0200	Binds to the 23S rRNA
H9L13_RS11510	COG1841	ribosomal large subunit assembly
H9L13_RS11515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L13_RS11520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L13_RS11525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9L13_RS11530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L13_RS11535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9L13_RS11540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L13_RS11545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L13_RS11550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L13_RS11555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L13_RS11560	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L13_RS11565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L13_RS11570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L13_RS11575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L13_RS11580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L13_RS11585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L13_RS11590	COG0089	rRNA binding
H9L13_RS11595	COG0088	Forms part of the polypeptide exit tunnel
H9L13_RS11600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L13_RS11605	COG0051	transcription antitermination factor activity, RNA binding
H9L13_RS11610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L13_RS11615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L13_RS11620	COG0049	tRNA binding
H9L13_RS11625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9L13_RS11635	COG1301	dicarboxylic acid transport
H9L13_RS11650	COG1228	amidohydrolase
H9L13_RS11655	COG0662	Cupin 2, conserved barrel domain protein
H9L13_RS11665	COG1228	amidohydrolase
H9L13_RS11670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L13_RS11685	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L13_RS11695	COG1956	GAF domain-containing protein
H9L13_RS11705	COG0564	pseudouridine synthase activity
H9L13_RS11710	COG0745	RESPONSE REGULATOR receiver
H9L13_RS11735	COG2815	serine threonine protein kinase
H9L13_RS11735	COG0515	serine threonine protein kinase
H9L13_RS11745	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9L13_RS11755	COG1228	amidohydrolase
H9L13_RS11760	COG1410	methionine synthase
H9L13_RS11760	COG0646	methionine synthase
H9L13_RS11790	COG0459	protein refolding
H9L13_RS11795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9L13_RS11805	COG0534	Mate efflux family protein
H9L13_RS11810	COG0616	signal peptide processing
H9L13_RS11820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L13_RS11855	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L13_RS11870	COG2827	Endonuclease containing a URI domain
H9L13_RS11875	COG0039	L-malate dehydrogenase activity
H9L13_RS11895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9L13_RS11905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9L13_RS11915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9L13_RS11920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9L13_RS11940	COG0784	Response regulator, receiver
H9L13_RS11955	COG0805	protein transport
H9L13_RS11960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L13_RS11965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L13_RS11970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9L13_RS11975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H9L13_RS11980	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L13_RS11995	COG0018	arginyl-trna synthetase
H9L13_RS12005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9L13_RS12015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9L13_RS12030	COG2271	Major facilitator Superfamily
H9L13_RS12035	COG0849	cell division
H9L13_RS12040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9L13_RS12045	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L13_RS12050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L13_RS12055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L13_RS12060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L13_RS12070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L13_RS12075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L13_RS12080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L13_RS12085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L13_RS12125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L13_RS12130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L13_RS12145	COG2193	ferroxidase activity
H9L13_RS12155	COG1160	GTP binding
H9L13_RS12160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L13_RS12170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9L13_RS12185	COG1959	2 iron, 2 sulfur cluster binding
H9L13_RS12200	COG0519	Catalyzes the synthesis of GMP from XMP
H9L13_RS12200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L13_RS12210	COG0203	ribosomal protein L17
H9L13_RS12220	COG0456	acetyltransferase
H9L13_RS12245	COG0316	Belongs to the HesB IscA family
H9L13_RS12250	COG0739	heme binding
H9L13_RS12280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9L13_RS12285	COG1254	Belongs to the acylphosphatase family
H9L13_RS12295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9L13_RS12305	COG0484	heat shock protein binding
H9L13_RS12315	COG0259	pyridoxamine-phosphate oxidase activity
H9L13_RS12330	COG0531	amino acid
H9L13_RS12340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L13_RS12345	COG0482	sulfurtransferase activity
H9L13_RS12370	COG2261	transglycosylase associated protein
H9L13_RS12385	COG2733	membrane
H9L13_RS12395	COG1228	amidohydrolase
H9L13_RS12400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9L13_RS12405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9L13_RS12415	COG0194	GDP metabolic process
H9L13_RS12430	COG0546	phosphoglycolate phosphatase activity
H9L13_RS12465	COG3243	poly(R)-hydroxyalkanoic acid synthase
H9L13_RS12485	COG0436	Aminotransferase
H9L13_RS12500	COG0861	Integral membrane protein TerC family
H9L13_RS12520	COG3710	Transcriptional regulator