locus-tag	class	description
H9L12_RS00010	COG1192	Involved in chromosome partitioning
H9L12_RS00025	COG2885	chlorophyll binding
H9L12_RS00030	COG0823	Involved in the tonB-independent uptake of proteins
H9L12_RS00050	COG0824	Thioesterase
H9L12_RS00060	COG2255	four-way junction helicase activity
H9L12_RS00080	COG0189	ligase activity
H9L12_RS00085	COG0632	four-way junction helicase activity
H9L12_RS00095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9L12_RS00100	COG0217	transcriptional regulatory protein
H9L12_RS00105	COG0393	Putative heavy-metal-binding
H9L12_RS00110	COG3750	Belongs to the UPF0335 family
H9L12_RS00115	COG0469	pyruvate kinase activity
H9L12_RS00120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9L12_RS00130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L12_RS00140	COG0346	lactoylglutathione lyase activity
H9L12_RS00145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L12_RS00145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L12_RS00165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9L12_RS00175	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS00180	COG1024	Enoyl-CoA hydratase
H9L12_RS00190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L12_RS00195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H9L12_RS00205	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H9L12_RS00235	COG4447	cellulose binding
H9L12_RS00245	COG1501	Belongs to the glycosyl hydrolase 31 family
H9L12_RS00265	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L12_RS00290	COG0129	dihydroxy-acid dehydratase activity
H9L12_RS00295	COG0477	Major facilitator Superfamily
H9L12_RS00305	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L12_RS00320	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L12_RS00320	COG3693	PFAM glycoside hydrolase, family 10
H9L12_RS00320	COG2382	esterase
H9L12_RS00335	COG3345	alpha-galactosidase
H9L12_RS00400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H9L12_RS00415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9L12_RS00420	COG1278	Cold shock
H9L12_RS00440	COG1494	fructose-1,6-bisphosphatase
H9L12_RS00465	COG0546	phosphoglycolate phosphatase activity
H9L12_RS00470	COG0564	pseudouridine synthase activity
H9L12_RS00485	COG2962	Rard protein
H9L12_RS00510	COG0436	Aminotransferase
H9L12_RS00525	COG0194	GDP metabolic process
H9L12_RS00535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9L12_RS00555	COG2733	membrane
H9L12_RS00595	COG0482	sulfurtransferase activity
H9L12_RS00615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9L12_RS00620	COG0259	pyridoxamine-phosphate oxidase activity
H9L12_RS00625	COG0484	heat shock protein binding
H9L12_RS00630	COG1295	ribonuclease BN
H9L12_RS00635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9L12_RS00640	COG1254	Belongs to the acylphosphatase family
H9L12_RS00645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9L12_RS00655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9L12_RS00670	COG0739	heme binding
H9L12_RS00680	COG0708	Exodeoxyribonuclease III
H9L12_RS00690	COG0456	acetyltransferase
H9L12_RS00725	COG0156	8-amino-7-oxononanoate synthase activity
H9L12_RS00745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L12_RS00775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L12_RS00780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L12_RS00815	COG1475	DNA binding
H9L12_RS00830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9L12_RS00860	COG0430	RNA-3'-phosphate cyclase activity
H9L12_RS00865	COG1690	Belongs to the RtcB family
H9L12_RS00870	COG4650	regulator
H9L12_RS00895	COG4771	TonB-dependent receptor
H9L12_RS00905	COG2272	Belongs to the type-B carboxylesterase lipase family
H9L12_RS00910	COG0318	PFAM AMP-dependent synthetase and ligase
H9L12_RS00975	COG4974	Belongs to the 'phage' integrase family
H9L12_RS01000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L12_RS01045	COG4957	zinc ion binding
H9L12_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
H9L12_RS01165	COG4771	TonB-dependent receptor
H9L12_RS01170	COG0277	FAD linked oxidase domain protein
H9L12_RS01180	COG0477	Major facilitator Superfamily
H9L12_RS01230	COG1309	transcriptional regulator
H9L12_RS01240	COG0457	Tetratricopeptide repeat
H9L12_RS01245	COG0438	transferase activity, transferring glycosyl groups
H9L12_RS01255	COG1682	transport, permease protein
H9L12_RS01260	COG1134	teichoic acid transport
H9L12_RS01265	COG3524	carbohydrate:proton symporter activity
H9L12_RS01270	COG4783	chaperone-mediated protein folding
H9L12_RS01270	COG1560	Kdo2-lipid A biosynthetic process
H9L12_RS01300	COG4771	TonB-dependent receptor
H9L12_RS01315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9L12_RS01325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9L12_RS01325	COG0131	Imidazoleglycerol-phosphate dehydratase
H9L12_RS01330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9L12_RS01335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9L12_RS01345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9L12_RS01345	COG0140	phosphoribosyl-ATP diphosphatase activity
H9L12_RS01355	COG3577	Aspartyl protease
H9L12_RS01385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L12_RS01430	COG3206	protein involved in exopolysaccharide biosynthesis
H9L12_RS01430	COG0489	protein tyrosine kinase activity
H9L12_RS01460	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H9L12_RS01515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H9L12_RS01585	COG0366	Alpha amylase catalytic
H9L12_RS01590	COG1082	Xylose isomerase domain protein TIM barrel
H9L12_RS01600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9L12_RS01605	COG0363	glucosamine-6-phosphate deaminase activity
H9L12_RS01610	COG0129	dihydroxy-acid dehydratase activity
H9L12_RS01640	COG0477	Major facilitator Superfamily
H9L12_RS01655	COG1064	alcohol dehydrogenase
H9L12_RS01660	COG2301	Belongs to the HpcH HpaI aldolase family
H9L12_RS01665	COG2030	dehydratase
H9L12_RS01685	COG1999	signal sequence binding
H9L12_RS01700	COG0473	3-isopropylmalate dehydrogenase activity
H9L12_RS01705	COG1012	belongs to the aldehyde dehydrogenase family
H9L12_RS01710	COG1733	regulation of RNA biosynthetic process
H9L12_RS01715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L12_RS01720	COG2259	Doxx family
H9L12_RS01725	COG3485	protocatechuate 3,4-dioxygenase
H9L12_RS01735	COG0022	dehydrogenase e1 component
H9L12_RS01760	COG1842	Phage shock protein A
H9L12_RS01770	COG4771	TonB-dependent receptor
H9L12_RS01775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L12_RS01775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L12_RS01805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9L12_RS01810	COG1695	Transcriptional regulator
H9L12_RS01815	COG0438	transferase activity, transferring glycosyl groups
H9L12_RS01865	COG1131	(ABC) transporter
H9L12_RS01895	COG1643	Atp-dependent helicase
H9L12_RS01910	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H9L12_RS01955	COG0488	(ABC) transporter
H9L12_RS01960	COG0438	transferase activity, transferring glycosyl groups
H9L12_RS01965	COG0366	Alpha amylase catalytic
H9L12_RS01970	COG2204	response regulator
H9L12_RS01990	COG0667	Aldo Keto reductase
H9L12_RS02005	COG2321	neutral zinc metallopeptidase
H9L12_RS02035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9L12_RS02040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9L12_RS02050	COG1435	thymidine kinase activity
H9L12_RS02060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L12_RS02085	COG0779	Required for maturation of 30S ribosomal subunits
H9L12_RS02090	COG1755	Isoprenylcysteine carboxyl methyltransferase
H9L12_RS02100	COG2133	pyrroloquinoline quinone binding
H9L12_RS02110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9L12_RS02120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L12_RS02125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9L12_RS02130	COG1253	flavin adenine dinucleotide binding
H9L12_RS02135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L12_RS02140	COG1702	phosphate starvation-inducible protein PhoH
H9L12_RS02145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L12_RS02185	COG1024	Enoyl-CoA hydratase
H9L12_RS02195	COG3243	poly(R)-hydroxyalkanoic acid synthase
H9L12_RS02200	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS02205	COG0625	glutathione transferase activity
H9L12_RS02255	COG0431	NADPH-dependent FMN reductase
H9L12_RS02260	COG3422	double-strand break repair
H9L12_RS02285	COG1012	belongs to the aldehyde dehydrogenase family
H9L12_RS02305	COG0837	glucose binding
H9L12_RS02310	COG0800	Aldolase
H9L12_RS02320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9L12_RS02335	COG0823	Involved in the tonB-independent uptake of proteins
H9L12_RS02335	COG1506	peptidase
H9L12_RS02350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L12_RS02360	COG0113	porphobilinogen synthase activity
H9L12_RS02400	COG3724	N-succinylarginine dihydrolase activity
H9L12_RS02415	COG1051	belongs to the nudix hydrolase family
H9L12_RS02425	COG0674	pyruvate-flavodoxin oxidoreductase activity
H9L12_RS02425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H9L12_RS02430	COG1013	pyruvate-flavodoxin oxidoreductase activity
H9L12_RS02445	COG0415	Belongs to the DNA photolyase family
H9L12_RS02450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L12_RS02460	COG4221	oxidoreductase activity
H9L12_RS02465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9L12_RS02475	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS02480	COG5001	Diguanylate cyclase
H9L12_RS02505	COG1278	Cold shock
H9L12_RS02515	COG2202	Pas domain
H9L12_RS02515	COG3920	Histidine kinase
H9L12_RS02525	COG0215	cysteine-tRNA ligase activity
H9L12_RS02540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9L12_RS02560	COG4974	Belongs to the 'phage' integrase family
H9L12_RS02565	COG0825	malonyl-CoA metabolic process
H9L12_RS02590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L12_RS02605	COG0302	gtp cyclohydrolase
H9L12_RS02630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L12_RS02665	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H9L12_RS02690	COG4695	Portal protein
H9L12_RS02700	COG2032	superoxide dismutase activity
H9L12_RS02705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L12_RS02715	COG0670	Belongs to the BI1 family
H9L12_RS02760	COG1722	exodeoxyribonuclease VII activity
H9L12_RS02765	COG0142	geranyltranstransferase activity
H9L12_RS02770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9L12_RS02780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9L12_RS02790	COG0730	response to heat
H9L12_RS02795	COG0343	queuine tRNA-ribosyltransferase activity
H9L12_RS02800	COG0513	Belongs to the DEAD box helicase family
H9L12_RS02835	COG1294	oxidase, subunit
H9L12_RS02860	COG0463	Glycosyl transferase, family 2
H9L12_RS02865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9L12_RS02875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L12_RS02880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L12_RS02885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L12_RS02890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L12_RS02900	COG0454	-acetyltransferase
H9L12_RS02910	COG2169	Transcriptional regulator
H9L12_RS02910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L12_RS02915	COG2169	Transcriptional regulator
H9L12_RS02915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L12_RS02935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L12_RS02950	COG0612	Peptidase, M16
H9L12_RS02990	COG5001	Diguanylate cyclase
H9L12_RS02995	COG1595	DNA-templated transcription, initiation
H9L12_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
H9L12_RS03075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L12_RS03080	COG1132	(ABC) transporter
H9L12_RS03095	COG0477	Major facilitator Superfamily
H9L12_RS03120	COG0183	Belongs to the thiolase family
H9L12_RS03135	COG0668	transmembrane transport
H9L12_RS03145	COG0693	protein deglycase activity
H9L12_RS03175	COG0729	surface antigen
H9L12_RS03195	COG0174	glutamine synthetase
H9L12_RS03225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9L12_RS03230	COG0024	Methionine aminopeptidase
H9L12_RS03270	COG0798	PFAM Bile acid sodium symporter
H9L12_RS03320	COG0789	Transcriptional regulator
H9L12_RS03365	COG2132	Multicopper oxidase
H9L12_RS03385	COG2226	methyltransferase
H9L12_RS03435	COG0070	glutamate synthase
H9L12_RS03435	COG0067	glutamate synthase
H9L12_RS03435	COG0069	glutamate synthase activity
H9L12_RS03450	COG0347	Belongs to the P(II) protein family
H9L12_RS03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L12_RS03500	COG0295	cytidine deaminase activity
H9L12_RS03510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9L12_RS03520	COG1566	PFAM secretion protein HlyD family protein
H9L12_RS03530	COG1164	Oligoendopeptidase f
H9L12_RS03535	COG2267	carboxylic ester hydrolase activity
H9L12_RS03545	COG0640	Transcriptional regulator
H9L12_RS03555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9L12_RS03560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9L12_RS03570	COG1612	heme a metabolic process
H9L12_RS03585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9L12_RS03605	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H9L12_RS03620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9L12_RS03625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L12_RS03655	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L12_RS03665	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS03675	COG1012	belongs to the aldehyde dehydrogenase family
H9L12_RS03700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L12_RS03710	COG0009	L-threonylcarbamoyladenylate synthase
H9L12_RS03715	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS03720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L12_RS03730	COG3104	oligopeptide transport
H9L12_RS03735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L12_RS03740	COG0402	S-adenosylhomocysteine deaminase activity
H9L12_RS03755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L12_RS03765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L12_RS03775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L12_RS03780	COG3698	Phosphodiester glycosidase
H9L12_RS03815	COG1794	racemase activity, acting on amino acids and derivatives
H9L12_RS03835	COG2967	ApaG domain
H9L12_RS03845	COG2003	Belongs to the UPF0758 family
H9L12_RS03855	COG0438	transferase activity, transferring glycosyl groups
H9L12_RS03860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9L12_RS03870	COG3206	protein involved in exopolysaccharide biosynthesis
H9L12_RS03870	COG0489	protein tyrosine kinase activity
H9L12_RS03920	COG1132	(ABC) transporter
H9L12_RS03925	COG1132	(ABC) transporter
H9L12_RS03935	COG0438	transferase activity, transferring glycosyl groups
H9L12_RS03955	COG0438	transferase activity, transferring glycosyl groups
H9L12_RS03965	COG1216	Glycosyl transferase, family 2
H9L12_RS03965	COG1442	glycosyl transferase family 8
H9L12_RS03975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9L12_RS04000	COG1454	alcohol dehydrogenase
H9L12_RS04040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9L12_RS04050	COG0772	Belongs to the SEDS family
H9L12_RS04075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9L12_RS04085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9L12_RS04090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L12_RS04095	COG3830	Belongs to the UPF0237 family
H9L12_RS04095	COG0560	Phosphoserine phosphatase
H9L12_RS04100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9L12_RS04125	COG0540	Belongs to the ATCase OTCase family
H9L12_RS04130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L12_RS04145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L12_RS04150	COG0154	amidase activity
H9L12_RS04155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L12_RS04170	COG0501	Belongs to the peptidase M48B family
H9L12_RS04190	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L12_RS04205	COG0740	serine-type endopeptidase activity
H9L12_RS04210	COG1392	Phosphate transport regulator
H9L12_RS04215	COG0306	phosphate transporter
H9L12_RS04235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9L12_RS04275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L12_RS04280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H9L12_RS04300	COG4235	cytochrome complex assembly
H9L12_RS04305	COG0686	Belongs to the AlaDH PNT family
H9L12_RS04310	COG3158	transport of potassium into the cell
H9L12_RS04340	COG0175	sulfate reduction
H9L12_RS04355	COG0438	transferase activity, transferring glycosyl groups
H9L12_RS04360	COG0442	prolyl-tRNA aminoacylation
H9L12_RS04370	COG1136	(ABC) transporter
H9L12_RS04380	COG0386	Belongs to the glutathione peroxidase family
H9L12_RS04385	COG2311	Membrane
H9L12_RS04410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9L12_RS04420	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L12_RS04425	COG0335	large ribosomal subunit rRNA binding
H9L12_RS04435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9L12_RS04465	COG0678	peroxiredoxin activity
H9L12_RS04470	COG1678	Uncharacterized ACR, COG1678
H9L12_RS04480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H9L12_RS04490	COG2205	protein histidine kinase activity
H9L12_RS04495	COG0802	atpase or kinase
H9L12_RS04505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9L12_RS04530	COG0653	protein targeting
H9L12_RS04550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9L12_RS04575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9L12_RS04585	COG3876	Protein conserved in bacteria
H9L12_RS04620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L12_RS04660	COG1610	YqeY-like protein
H9L12_RS04665	COG0505	Belongs to the CarA family
H9L12_RS04680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L12_RS04715	COG0148	phosphopyruvate hydratase activity
H9L12_RS04725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9L12_RS04730	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L12_RS04730	COG0022	dehydrogenase e1 component
H9L12_RS04750	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H9L12_RS04765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L12_RS04780	COG2202	Pas domain
H9L12_RS04780	COG2205	protein histidine kinase activity
H9L12_RS04790	COG1940	carbohydrate kinase activity
H9L12_RS04815	COG0741	lytic transglycosylase activity
H9L12_RS04840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9L12_RS04845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9L12_RS04845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9L12_RS04850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L12_RS04895	COG2945	thiolester hydrolase activity
H9L12_RS04905	COG1104	cysteine desulfurase activity
H9L12_RS04925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L12_RS04930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9L12_RS04935	COG0318	PFAM AMP-dependent synthetase and ligase
H9L12_RS04945	COG2259	Doxx family
H9L12_RS04965	COG0288	reversible hydration of carbon dioxide
H9L12_RS04970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9L12_RS04980	COG1058	Belongs to the CinA family
H9L12_RS04980	COG1546	Belongs to the CinA family
H9L12_RS04985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9L12_RS04985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9L12_RS04995	COG5000	phosphorelay sensor kinase activity
H9L12_RS05000	COG2204	response regulator
H9L12_RS05010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L12_RS05015	COG3956	TIGRFAM MazG family protein
H9L12_RS05040	COG0470	DNA polymerase III
H9L12_RS05045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9L12_RS05050	COG1686	Belongs to the peptidase S11 family
H9L12_RS05055	COG2951	lytic endotransglycosylase activity
H9L12_RS05065	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS05075	COG0254	rRNA binding
H9L12_RS05100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H9L12_RS05105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9L12_RS05115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L12_RS05120	COG0750	zinc metalloprotease
H9L12_RS05135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L12_RS05140	COG0233	cytoplasmic translational termination
H9L12_RS05145	COG0528	UMP kinase activity
H9L12_RS05150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L12_RS05155	COG0052	Belongs to the universal ribosomal protein uS2 family
H9L12_RS05170	COG0688	phosphatidylethanolamine metabolic process
H9L12_RS05175	COG0538	isocitrate dehydrogenase activity
H9L12_RS05180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L12_RS05195	COG0492	ferredoxin-NADP+ reductase activity
H9L12_RS05200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L12_RS05205	COG0228	four-way junction DNA binding
H9L12_RS05225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9L12_RS05230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L12_RS05235	COG0552	protein localization to endoplasmic reticulum
H9L12_RS05240	COG2917	probably involved in intracellular septation
H9L12_RS05245	COG1131	(ABC) transporter
H9L12_RS05250	COG0842	Transport permease protein
H9L12_RS05260	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9L12_RS05265	COG1842	Phage shock protein A
H9L12_RS05305	COG2166	iron-sulfur cluster assembly
H9L12_RS05325	COG3023	N-Acetylmuramoyl-L-alanine amidase
H9L12_RS05340	COG0745	RESPONSE REGULATOR receiver
H9L12_RS05350	COG2198	Histidine kinase
H9L12_RS05350	COG0784	Response regulator, receiver
H9L12_RS05350	COG0643	Histidine kinase
H9L12_RS05360	COG0564	pseudouridine synthase activity
H9L12_RS05365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L12_RS05375	COG1301	dicarboxylic acid transport
H9L12_RS05380	COG0006	proline dipeptidase activity
H9L12_RS05390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9L12_RS05405	COG3590	peptidase
H9L12_RS05420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L12_RS05430	COG0741	lytic transglycosylase activity
H9L12_RS05445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L12_RS05450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H9L12_RS05490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L12_RS05495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9L12_RS05510	COG0105	UTP biosynthetic process
H9L12_RS05525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L12_RS05530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H9L12_RS05540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9L12_RS05545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L12_RS05565	COG2301	Belongs to the HpcH HpaI aldolase family
H9L12_RS05570	COG0330	HflC and HflK could
H9L12_RS05580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9L12_RS05585	COG0745	RESPONSE REGULATOR receiver
H9L12_RS05595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H9L12_RS05600	COG1660	Displays ATPase and GTPase activities
H9L12_RS05605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L12_RS05605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L12_RS05610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L12_RS05645	COG0242	peptide deformylase activity
H9L12_RS05650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L12_RS05655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9L12_RS05660	COG0101	tRNA pseudouridine synthase activity
H9L12_RS05665	COG0019	diaminopimelate decarboxylase activity
H9L12_RS05670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H9L12_RS05685	COG0492	ferredoxin-NADP+ reductase activity
H9L12_RS05705	COG0504	CTP synthase activity
H9L12_RS05715	COG0149	triose-phosphate isomerase activity
H9L12_RS05730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L12_RS05745	COG0658	competence protein
H9L12_RS05745	COG2333	competence protein COMEC
H9L12_RS05750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L12_RS05800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H9L12_RS05815	COG1007	ATP synthesis coupled electron transport
H9L12_RS05830	COG0713	ATP synthesis coupled electron transport
H9L12_RS05840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L12_RS05845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9L12_RS05850	COG1034	ATP synthesis coupled electron transport
H9L12_RS05870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H9L12_RS05885	COG0649	NAD binding
H9L12_RS05890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L12_RS05895	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L12_RS05900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L12_RS05910	COG0483	inositol monophosphate 1-phosphatase activity
H9L12_RS05915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L12_RS05945	COG3588	fructose-bisphosphate aldolase
H9L12_RS05955	COG0126	phosphoglycerate kinase activity
H9L12_RS06020	COG0606	chelatase, subunit chli
H9L12_RS06045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9L12_RS06050	COG0594	ribonuclease P activity
H9L12_RS06055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9L12_RS06060	COG0706	membrane insertase activity
H9L12_RS06065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9L12_RS06080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L12_RS06085	COG3300	MHYT domain
H9L12_RS06085	COG5001	Diguanylate cyclase
H9L12_RS06105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9L12_RS06110	COG0728	peptidoglycan biosynthetic process
H9L12_RS06115	COG0180	Tryptophanyl-tRNA synthetase
H9L12_RS06130	COG0268	Binds directly to 16S ribosomal RNA
H9L12_RS06140	COG2226	methyltransferase
H9L12_RS06155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9L12_RS06160	COG0756	dUTP diphosphatase activity
H9L12_RS06165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9L12_RS06180	COG0758	DNA mediated transformation
H9L12_RS06190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9L12_RS06195	COG0156	8-amino-7-oxononanoate synthase activity
H9L12_RS06200	COG0698	ribose 5-phosphate isomerase
H9L12_RS06205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L12_RS06210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L12_RS06235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L12_RS06245	COG2957	Belongs to the agmatine deiminase family
H9L12_RS06260	COG1573	uracil-dna glycosylase
H9L12_RS06265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9L12_RS06305	COG0671	phosphoesterase, PA-phosphatase related
H9L12_RS06325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L12_RS06330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L12_RS06335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L12_RS06340	COG0509	glycine decarboxylation via glycine cleavage system
H9L12_RS06345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9L12_RS06355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9L12_RS06360	COG0328	RNA-DNA hybrid ribonuclease activity
H9L12_RS06380	COG4964	Belongs to the GSP D family
H9L12_RS06440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9L12_RS06445	COG0193	aminoacyl-tRNA hydrolase activity
H9L12_RS06460	COG0012	GTP binding
H9L12_RS06475	COG2234	aminopeptidase activity
H9L12_RS06490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L12_RS06495	COG2857	Cytochrome c1
H9L12_RS06495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9L12_RS06505	COG0723	plastoquinol--plastocyanin reductase activity
H9L12_RS06510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9L12_RS06515	COG0408	coproporphyrinogen oxidase activity
H9L12_RS06525	COG0321	lipoyl(octanoyl) transferase activity
H9L12_RS06545	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9L12_RS06560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9L12_RS06570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L12_RS06575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9L12_RS06590	COG0842	Transport permease protein
H9L12_RS06600	COG0071	Belongs to the small heat shock protein (HSP20) family
H9L12_RS06605	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H9L12_RS06615	COG0187	DNA topoisomerase II activity
H9L12_RS06625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L12_RS06635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L12_RS06645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L12_RS06665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9L12_RS06670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L12_RS06675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L12_RS06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L12_RS06695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L12_RS06700	COG1420	regulation of RNA biosynthetic process
H9L12_RS06715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L12_RS06725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L12_RS06735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9L12_RS06740	COG0792	nuclease activity
H9L12_RS06745	COG0189	ligase activity
H9L12_RS06750	COG0586	Pfam SNARE associated Golgi protein
H9L12_RS06755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H9L12_RS06765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9L12_RS06770	COG1024	Enoyl-CoA hydratase
H9L12_RS06815	COG0166	Belongs to the GPI family
H9L12_RS06825	COG0571	ribonuclease III activity
H9L12_RS06830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9L12_RS06835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9L12_RS06850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9L12_RS06885	COG2267	carboxylic ester hydrolase activity
H9L12_RS06890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9L12_RS06905	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H9L12_RS06915	COG0640	Transcriptional regulator
H9L12_RS06945	COG4251	negative regulation of phosphorylation
H9L12_RS06950	COG0784	Response regulator, receiver
H9L12_RS06955	COG0745	RESPONSE REGULATOR receiver
H9L12_RS06960	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L12_RS06965	COG0022	dehydrogenase e1 component
H9L12_RS06970	COG1448	Aminotransferase
H9L12_RS06975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9L12_RS06980	COG3396	Phenylacetate-CoA oxygenase
H9L12_RS06985	COG3460	Phenylacetate-CoA oxygenase
H9L12_RS06990	COG3396	Phenylacetate-CoA oxygenase
H9L12_RS06995	COG1733	regulation of RNA biosynthetic process
H9L12_RS07010	COG1024	Enoyl-CoA hydratase
H9L12_RS07025	COG1012	belongs to the aldehyde dehydrogenase family
H9L12_RS07025	COG2030	dehydratase
H9L12_RS07030	COG0517	IMP dehydrogenase activity
H9L12_RS07040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L12_RS07045	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L12_RS07050	COG0356	it plays a direct role in the translocation of protons across the membrane
H9L12_RS07080	COG2003	Belongs to the UPF0758 family
H9L12_RS07090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9L12_RS07110	COG0443	Heat shock 70 kDa protein
H9L12_RS07125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H9L12_RS07160	COG0359	binds to the 23S rRNA
H9L12_RS07185	COG3549	Plasmid maintenance system killer
H9L12_RS07240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9L12_RS07245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L12_RS07250	COG3590	peptidase
H9L12_RS07255	COG2202	Pas domain
H9L12_RS07255	COG3920	Histidine kinase
H9L12_RS07265	COG0387	Pfam Sodium calcium exchanger
H9L12_RS07275	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS07285	COG0183	Belongs to the thiolase family
H9L12_RS07310	COG1408	metallophosphoesterase
H9L12_RS07350	COG1704	LemA family
H9L12_RS07355	COG1970	mechanosensitive ion channel activity
H9L12_RS07385	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9L12_RS07390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L12_RS07445	COG0210	DNA helicase
H9L12_RS07485	COG0284	orotidine-5'-phosphate decarboxylase activity
H9L12_RS07495	COG0285	dihydrofolate synthase activity
H9L12_RS07500	COG2223	nitrite transmembrane transporter activity
H9L12_RS07505	COG4638	Rieske (2fe-2S)
H9L12_RS07520	COG0742	ribosomal rna small subunit methyltransferase
H9L12_RS07550	COG1045	serine acetyltransferase
H9L12_RS07560	COG0583	DNA-binding transcription factor activity
H9L12_RS07565	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9L12_RS07570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L12_RS07585	COG3300	MHYT domain
H9L12_RS07585	COG5001	Diguanylate cyclase
H9L12_RS07600	COG0539	negative regulation of cytoplasmic translation
H9L12_RS07625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L12_RS07680	COG1522	sequence-specific DNA binding
H9L12_RS07685	COG3384	dioxygenase
H9L12_RS07715	COG0747	negative chemotaxis
H9L12_RS07735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9L12_RS07760	COG0297	glycogen (starch) synthase activity
H9L12_RS07765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9L12_RS07865	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS07890	COG0028	Belongs to the TPP enzyme family
H9L12_RS07895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9L12_RS07905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9L12_RS07910	COG0511	ligase activity, forming carbon-carbon bonds
H9L12_RS07915	COG0439	Biotin carboxylase
H9L12_RS07940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9L12_RS07960	COG1278	Cold shock
H9L12_RS07985	COG0250	Participates in transcription elongation, termination and antitermination
H9L12_RS07990	COG4191	Histidine kinase
H9L12_RS07990	COG0784	Response regulator, receiver
H9L12_RS08010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L12_RS08015	COG0081	regulation of translation
H9L12_RS08025	COG2326	polyphosphate kinase activity
H9L12_RS08040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9L12_RS08050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9L12_RS08055	COG0222	ribosome binding
H9L12_RS08065	COG3920	Histidine kinase
H9L12_RS08075	COG0085	RNA polymerase activity
H9L12_RS08080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L12_RS08150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9L12_RS08160	COG1530	ribonuclease E activity
H9L12_RS08165	COG0501	Belongs to the peptidase M48B family
H9L12_RS08180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9L12_RS08185	COG0248	Ppx GppA phosphatase
H9L12_RS08200	COG3773	Cell wall hydrolase
H9L12_RS08200	COG3409	Peptidoglycan-binding domain 1 protein
H9L12_RS08245	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L12_RS08245	COG1024	Enoyl-CoA hydratase
H9L12_RS08270	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS08275	COG1960	acyl-CoA dehydrogenase activity
H9L12_RS08290	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L12_RS08405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9L12_RS08430	COG0071	Belongs to the small heat shock protein (HSP20) family
H9L12_RS08440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9L12_RS08450	COG0277	FAD linked oxidase domain protein
H9L12_RS08465	COG0563	adenylate kinase activity
H9L12_RS08470	COG0201	protein transport
H9L12_RS08475	COG0200	Binds to the 23S rRNA
H9L12_RS08480	COG1841	ribosomal large subunit assembly
H9L12_RS08485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L12_RS08490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L12_RS08495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9L12_RS08500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L12_RS08505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9L12_RS08510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L12_RS08515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L12_RS08520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L12_RS08525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L12_RS08530	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L12_RS08535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L12_RS08540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L12_RS08545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L12_RS08550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L12_RS08555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L12_RS08560	COG0089	rRNA binding
H9L12_RS08565	COG0088	Forms part of the polypeptide exit tunnel
H9L12_RS08570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L12_RS08575	COG0051	transcription antitermination factor activity, RNA binding
H9L12_RS08580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L12_RS08585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L12_RS08590	COG0049	tRNA binding
H9L12_RS08595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9L12_RS08605	COG0662	Cupin 2, conserved barrel domain protein
H9L12_RS08615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L12_RS08630	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L12_RS08645	COG1956	GAF domain-containing protein
H9L12_RS08655	COG0564	pseudouridine synthase activity
H9L12_RS08660	COG0745	RESPONSE REGULATOR receiver
H9L12_RS08675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9L12_RS08680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9L12_RS08730	COG1842	Phage shock protein A
H9L12_RS08740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9L12_RS08745	COG0534	Mate efflux family protein
H9L12_RS08750	COG0616	signal peptide processing
H9L12_RS08765	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L12_RS08775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9L12_RS08780	COG0039	L-malate dehydrogenase activity
H9L12_RS08790	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9L12_RS08810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9L12_RS08835	COG0784	Response regulator, receiver
H9L12_RS08845	COG0805	protein transport
H9L12_RS08850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L12_RS08855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L12_RS08860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9L12_RS08865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H9L12_RS08870	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L12_RS08885	COG0018	arginyl-trna synthetase
H9L12_RS08890	COG1823	symporter activity
H9L12_RS08900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9L12_RS08910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9L12_RS08915	COG0849	cell division
H9L12_RS08920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9L12_RS08925	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L12_RS08930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L12_RS08935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L12_RS08940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L12_RS08950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L12_RS08955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L12_RS08960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L12_RS08965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L12_RS08985	COG2001	Belongs to the MraZ family
H9L12_RS09035	COG2311	Membrane
H9L12_RS09050	COG1160	GTP binding
H9L12_RS09065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9L12_RS09080	COG1393	Belongs to the ArsC family
H9L12_RS09095	COG0519	Catalyzes the synthesis of GMP from XMP
H9L12_RS09095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L12_RS09105	COG0745	RESPONSE REGULATOR receiver
H9L12_RS09140	COG0203	ribosomal protein L17
H9L12_RS09145	COG0202	RNA polymerase activity
H9L12_RS09150	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9L12_RS09155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L12_RS09160	COG0196	riboflavin kinase activity
H9L12_RS09165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9L12_RS09180	COG0745	RESPONSE REGULATOR receiver
H9L12_RS09195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9L12_RS09205	COG1297	OPT oligopeptide transporter protein
H9L12_RS09225	COG0433	COG0433 Predicted ATPase
H9L12_RS09245	COG0489	protein tyrosine kinase activity
H9L12_RS09250	COG1832	CoA-binding protein
H9L12_RS09255	COG0312	modulator of DNA gyrase
H9L12_RS09260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9L12_RS09265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L12_RS09275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9L12_RS09295	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H9L12_RS09325	COG5002	protein histidine kinase activity
H9L12_RS09335	COG0573	inorganic phosphate transmembrane transporter activity
H9L12_RS09350	COG0704	Plays a role in the regulation of phosphate uptake
H9L12_RS09355	COG0745	RESPONSE REGULATOR receiver
H9L12_RS09360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L12_RS09380	COG4999	Histidine kinase
H9L12_RS09380	COG2205	protein histidine kinase activity
H9L12_RS09380	COG3850	Histidine kinase
H9L12_RS09380	COG3437	response regulator, receiver
H9L12_RS09385	COG0784	Response regulator, receiver
H9L12_RS09385	COG4191	Histidine kinase
H9L12_RS09390	COG1609	Transcriptional regulator
H9L12_RS09405	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L12_RS09465	COG0582	viral genome integration into host DNA
H9L12_RS09520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L12_RS09530	COG2070	2-Nitropropane dioxygenase
H9L12_RS09555	COG0037	tRNA processing
H9L12_RS09575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L12_RS09580	COG0799	negative regulation of ribosome biogenesis
H9L12_RS09585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9L12_RS09595	COG0793	Belongs to the peptidase S41A family
H9L12_RS09605	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H9L12_RS09625	COG3128	pkhd-type hydroxylase
H9L12_RS09645	COG1196	nuclear chromosome segregation
H9L12_RS09660	COG1194	a g-specific adenine glycosylase
H9L12_RS09665	COG2816	NAD+ diphosphatase activity
H9L12_RS09670	COG3474	cytochrome
H9L12_RS09680	COG1611	Belongs to the LOG family
H9L12_RS09685	COG1053	succinate dehydrogenase
H9L12_RS09700	COG0840	transmembrane signaling receptor activity
H9L12_RS09750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L12_RS09760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L12_RS09765	COG1862	Preprotein translocase
H9L12_RS09775	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L12_RS09800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9L12_RS09805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9L12_RS09815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L12_RS09850	COG0556	nucleotide-excision repair
H9L12_RS09870	COG1597	lipid kinase activity
H9L12_RS09890	COG1372	Participates in initiation and elongation during chromosome replication
H9L12_RS09890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L12_RS09950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L12_RS09980	COG1496	oxidoreductase activity
H9L12_RS09995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9L12_RS10000	COG0318	PFAM AMP-dependent synthetase and ligase
H9L12_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
H9L12_RS10160	COG0156	8-amino-7-oxononanoate synthase activity
H9L12_RS10165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L12_RS10240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L12_RS10260	COG0659	secondary active sulfate transmembrane transporter activity
H9L12_RS10360	COG0308	aminopeptidase N
H9L12_RS10400	COG0625	glutathione transferase activity
H9L12_RS10405	COG0235	Class ii aldolase
H9L12_RS10435	COG0493	'glutamate synthase
H9L12_RS10455	COG0542	response to heat
H9L12_RS10465	COG0457	Tetratricopeptide repeat
H9L12_RS10480	COG1570	exodeoxyribonuclease VII activity
H9L12_RS10495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L12_RS10495	COG3743	rRNA binding
H9L12_RS10500	COG1253	flavin adenine dinucleotide binding
H9L12_RS10505	COG0590	tRNA wobble adenosine to inosine editing
H9L12_RS10515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L12_RS10550	COG5507	3-demethylubiquinone-9 3-methyltransferase
H9L12_RS10590	COG0484	heat shock protein binding
H9L12_RS10600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L12_RS10620	COG0596	Alpha beta hydrolase
H9L12_RS10625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L12_RS10630	COG2819	hydrolase of the alpha beta superfamily
H9L12_RS10640	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H9L12_RS10650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L12_RS10655	COG0424	maF-like protein
H9L12_RS10670	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H9L12_RS10680	COG0460	homoserine dehydrogenase
H9L12_RS10690	COG0083	homoserine kinase activity
H9L12_RS10695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9L12_RS10705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9L12_RS10725	COG1595	DNA-templated transcription, initiation
H9L12_RS10755	COG2086	electron transfer activity
H9L12_RS10800	COG2239	Acts as a magnesium transporter
H9L12_RS10810	COG2311	Membrane
H9L12_RS10820	COG4221	oxidoreductase activity
H9L12_RS10825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L12_RS10845	COG1758	RNA polymerase activity
H9L12_RS10865	COG0280	phosphate acetyltransferase
H9L12_RS10865	COG0281	malic enzyme
H9L12_RS10875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H9L12_RS10880	COG4771	TonB-dependent receptor
H9L12_RS10885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L12_RS10965	COG0167	dihydroorotate dehydrogenase activity
H9L12_RS10980	COG0719	Fe-S assembly protein
H9L12_RS10990	COG0396	ATPase activity
H9L12_RS11000	COG0719	Fe-S assembly protein
H9L12_RS11005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L12_RS11010	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L12_RS11015	COG0316	Belongs to the HesB IscA family
H9L12_RS11025	COG2020	methyltransferase activity
H9L12_RS11030	COG1404	Belongs to the peptidase S8 family
H9L12_RS11040	COG2171	N-acyltransferase activity
H9L12_RS11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L12_RS11055	COG0165	Argininosuccinate lyase
H9L12_RS11070	COG0745	RESPONSE REGULATOR receiver
H9L12_RS11095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L12_RS11110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L12_RS11115	COG2095	MarC family integral membrane protein
H9L12_RS11130	COG0463	Glycosyl transferase, family 2
H9L12_RS11145	COG0137	argininosuccinate synthase activity
H9L12_RS11170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9L12_RS11190	COG1215	transferase activity, transferring glycosyl groups
H9L12_RS11220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9L12_RS11230	COG0739	heme binding
H9L12_RS11245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9L12_RS11300	COG2267	carboxylic ester hydrolase activity
H9L12_RS11330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9L12_RS11360	COG5265	(ABC) transporter
H9L12_RS11400	COG0514	ATP-dependent DNA helicase (RecQ)
H9L12_RS11415	COG0312	modulator of DNA gyrase
H9L12_RS11430	COG1131	(ABC) transporter
H9L12_RS11440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9L12_RS11455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L12_RS11455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L12_RS11465	COG0138	bifunctional purine biosynthesis protein purh
H9L12_RS11485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9L12_RS11505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L12_RS11510	COG0181	hydroxymethylbilane synthase activity
H9L12_RS11535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L12_RS11550	COG3118	belongs to the thioredoxin family
H9L12_RS11560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L12_RS11565	COG1674	ftsk spoiiie
H9L12_RS11585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L12_RS11585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9L12_RS11595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9L12_RS11645	COG0445	tRNA wobble uridine modification
H9L12_RS11650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9L12_RS11655	COG0861	Integral membrane protein TerC family
H9L12_RS11670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9L12_RS11675	COG0424	maF-like protein
H9L12_RS11680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9L12_RS11685	COG0237	dephospho-CoA kinase activity
H9L12_RS11690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L12_RS11695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9L12_RS11700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L12_RS11730	COG2983	Belongs to the UPF0260 family
H9L12_RS11810	COG0204	Acyl-transferase
H9L12_RS11835	COG2224	Isocitrate lyase
H9L12_RS11845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9L12_RS11855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L12_RS11860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L12_RS11905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9L12_RS11910	COG1902	pentaerythritol trinitrate reductase activity
H9L12_RS11955	COG3483	tryptophan 2,3-dioxygenase activity
H9L12_RS11970	COG4771	TonB-dependent receptor
H9L12_RS11980	COG2814	Major facilitator Superfamily
H9L12_RS12015	COG0513	Belongs to the DEAD box helicase family
H9L12_RS12035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H9L12_RS12040	COG1137	ATPase activity
H9L12_RS12060	COG1278	Cold shock
H9L12_RS12090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L12_RS12160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9L12_RS12170	COG0697	spore germination
H9L12_RS12180	COG2076	Multidrug Resistance protein
H9L12_RS12185	COG0154	amidase activity
H9L12_RS12190	COG4771	TonB-dependent receptor
H9L12_RS12200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9L12_RS12210	COG0124	histidyl-tRNA synthetase
H9L12_RS12215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L12_RS12235	COG3746	phosphate-selective porin O and P
H9L12_RS12255	COG1607	acyl-coa hydrolase
H9L12_RS12265	COG0517	IMP dehydrogenase activity
H9L12_RS12300	COG0488	(ABC) transporter
H9L12_RS12310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9L12_RS12310	COG0512	Glutamine amidotransferase of anthranilate synthase
H9L12_RS12320	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H9L12_RS12360	COG0010	Belongs to the arginase family
H9L12_RS12370	COG1253	flavin adenine dinucleotide binding
H9L12_RS12380	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9L12_RS12400	COG2986	histidine ammonia-lyase
H9L12_RS12430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L12_RS12435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L12_RS12445	COG2354	Protein conserved in bacteria
H9L12_RS12450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L12_RS12455	COG0625	glutathione transferase activity
H9L12_RS12505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9L12_RS12520	COG0588	phosphoglycerate mutase activity
H9L12_RS12525	COG2866	Carboxypeptidase
H9L12_RS12535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9L12_RS12555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9L12_RS12560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H9L12_RS12565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9L12_RS12570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9L12_RS12605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9L12_RS12610	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L12_RS12620	COG0681	Belongs to the peptidase S26 family
H9L12_RS12625	COG0736	holo-[acyl-carrier-protein] synthase activity
H9L12_RS12630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9L12_RS12635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9L12_RS12640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9L12_RS12645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9L12_RS12665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L12_RS12670	COG0109	protoheme IX farnesyltransferase activity
H9L12_RS12675	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H9L12_RS12695	COG0612	Peptidase, M16
H9L12_RS12705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L12_RS12710	COG4133	protoheme IX ABC transporter activity
H9L12_RS12745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L12_RS12755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9L12_RS12765	COG0133	tryptophan synthase activity
H9L12_RS12770	COG0159	tryptophan synthase activity
H9L12_RS12775	COG1278	Cold shock
H9L12_RS12780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L12_RS12790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9L12_RS12800	COG3279	Response regulator of the LytR AlgR family
H9L12_RS12805	COG3275	phosphorelay sensor kinase activity
H9L12_RS12815	COG3300	MHYT domain
H9L12_RS12815	COG5001	Diguanylate cyclase
H9L12_RS12825	COG0745	RESPONSE REGULATOR receiver
H9L12_RS12835	COG5001	Diguanylate cyclase
H9L12_RS12845	COG3186	Phenylalanine-4-hydroxylase
H9L12_RS12850	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9L12_RS12860	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L12_RS12870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9L12_RS12875	COG1301	dicarboxylic acid transport
H9L12_RS12880	COG0531	amino acid
H9L12_RS12895	COG0114	fumarate hydratase activity
H9L12_RS12910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H9L12_RS12950	COG0596	Alpha beta hydrolase
H9L12_RS12980	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H9L12_RS12995	COG0776	regulation of translation
H9L12_RS13000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L12_RS13005	COG0416	fatty acid biosynthetic process
H9L12_RS13010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L12_RS13025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L12_RS13060	COG1201	RNA secondary structure unwinding