locus-tag	class	description
HL653_RS00005	ENOG4108ZP8	Acetolactate synthase small subunit
HL653_RS00010	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HL653_RS00070	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HL653_RS00080	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HL653_RS00090	ENOG4105YVS	arsR family transcriptional regulator
HL653_RS00095	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HL653_RS00100	ENOG4107SDU	Methyl-accepting chemotaxis
HL653_RS00105	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HL653_RS00120	ENOG4105CP7	Triose-phosphate isomerase
HL653_RS00125	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HL653_RS00130	ENOG4105CRQ	synthase (Component I)
HL653_RS00150	ENOG4105DDQ	anthranilate synthase
HL653_RS00155	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HL653_RS00165	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HL653_RS00170	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL653_RS00175	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HL653_RS00180	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HL653_RS00205	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS00210	ENOG4105CUB	amino acid
HL653_RS00225	ENOG4105C57	major facilitator superfamily
HL653_RS00235	ENOG4105D9R	oxidoreductase
HL653_RS00245	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL653_RS00255	ENOG4105C0B	DNA polymerase III (alpha subunit)
HL653_RS00260	ENOG4105BZU	Histidine kinase
HL653_RS00300	ENOG4105D85	methylase
HL653_RS00310	ENOG4105F6A	helicase
HL653_RS00315	ENOG4105ECI	YeeC-like protein
HL653_RS00350	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HL653_RS00355	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HL653_RS00415	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HL653_RS00420	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
HL653_RS00425	ENOG4107RE3	peptidase, S41
HL653_RS00435	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HL653_RS00445	ENOG4105VIE	preprotein translocase, subunit YajC
HL653_RS00465	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS00490	ENOG4107Z36	nucleotidyl transferase
HL653_RS00515	ENOG4105CI3	gtp-binding protein typa
HL653_RS00570	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HL653_RS00585	ENOG4107T5V	SNARE associated Golgi
HL653_RS00600	ENOG4105C1J	atp-dependent rna helicase
HL653_RS00610	ENOG41083MR	nifu domain-containing protein
HL653_RS00620	ENOG41072GX	Peptidase M22 Glycoprotease
HL653_RS00630	ENOG41090R7	Ferric uptake
HL653_RS00640	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HL653_RS00665	ENOG4105CI0	Citrate lyase
HL653_RS00675	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HL653_RS00685	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HL653_RS00690	ENOG4107E2E	PKHD-type hydroxylase
HL653_RS00695	ENOG4105WQ5	TonB family
HL653_RS00700	ENOG4108ESX	Receptor
HL653_RS00710	ENOG4105CHR	reductase
HL653_RS00725	ENOG4105D7W	serine acetyltransferase
HL653_RS00730	ENOG4105BZG	amino acid carrier protein
HL653_RS00750	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HL653_RS00765	ENOG4105CG5	Glycosyl transferase (Group 1
HL653_RS00780	ENOG4105D05	Receptor
HL653_RS00810	ENOG4105CMG	Carbohydrate kinase
HL653_RS00830	ENOG4105GSS	Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity)
HL653_RS00845	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HL653_RS00855	ENOG4105DA5	(ABC) transporter
HL653_RS00860	ENOG4105E3A	(ABC) transporter
HL653_RS00865	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HL653_RS00870	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL653_RS00895	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HL653_RS00910	ENOG4105C79	DNA protecting protein DprA
HL653_RS00915	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HL653_RS00920	ENOG41067RQ	csbd family
HL653_RS00935	ENOG4105CHM	Aminotransferase
HL653_RS00940	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HL653_RS00975	ENOG4108K5P	(LipO)protein
HL653_RS00975	ENOG4108K5P	(LipO)protein
HL653_RS00980	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HL653_RS00985	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HL653_RS01005	ENOG4105C8Y	Acetylornithine aminotransferase
HL653_RS01010	ENOG4105DBV	ornithine carbamoyltransferase
HL653_RS01020	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HL653_RS01025	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HL653_RS01040	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HL653_RS01055	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HL653_RS01060	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HL653_RS01065	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HL653_RS01070	ENOG4105EIX	cytochrome c1
HL653_RS01090	ENOG4108UJV	acyl-CoA thioesterase i
HL653_RS01095	ENOG4108I0Y	(ABC) transporter
HL653_RS01105	ENOG4107SQD	Transcriptional regulator, GntR family
HL653_RS01130	ENOG4105CNT	hydrolase family 2
HL653_RS01135	ENOG4105JXH	GntR family transcriptional regulator
HL653_RS01140	ENOG4105DPW	Major facilitator superfamily MFS_1
HL653_RS01150	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
HL653_RS01160	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HL653_RS01175	ENOG4107ZSV	Receptor
HL653_RS01200	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HL653_RS01225	ENOG4105CFG	Acts as a chaperone (By similarity)
HL653_RS01240	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL653_RS01245	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HL653_RS01260	ENOG4105DHZ	alpha beta
HL653_RS01265	ENOG4105C3J	Cysteine desulfurase
HL653_RS01280	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HL653_RS01285	ENOG4105MPN	Membrane
HL653_RS01295	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HL653_RS01300	ENOG4105F4X	arginine
HL653_RS01310	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HL653_RS01320	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HL653_RS01325	ENOG4105PDP	Short chain dehydrogenase
HL653_RS01330	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HL653_RS01335	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HL653_RS01350	ENOG4105DC7	peptidase M24
HL653_RS01370	ENOG4105EMU	Dehydrogenase
HL653_RS01390	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HL653_RS01410	ENOG4108I0Z	Aconitate hydratase
HL653_RS01430	ENOG4105CD3	dihydroorotase
HL653_RS01440	ENOG4105C28	cystathionine
HL653_RS01450	ENOG4105HHA	aminodeoxychorismate lyase
HL653_RS01455	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HL653_RS01475	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HL653_RS01490	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HL653_RS01500	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HL653_RS01510	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HL653_RS01520	ENOG4105CSA	Coproporphyrinogen iii oxidase
HL653_RS01525	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HL653_RS01530	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HL653_RS01535	ENOG41082FP	UPF0102 protein
HL653_RS01540	ENOG4105D7Z	glutathione synthase
HL653_RS01545	ENOG4105UGU	tonB-dependent Receptor
HL653_RS01550	ENOG4105E90	ABC transporter
HL653_RS01555	ENOG4108IJ8	ABC transporter
HL653_RS01560	ENOG4105KZX	Pterin carbinolamine dehydratase
HL653_RS01570	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HL653_RS01575	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HL653_RS01590	ENOG4105C1V	Peptidase, M16
HL653_RS01595	ENOG4105D98	threonine synthase
HL653_RS01605	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HL653_RS01615	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HL653_RS01620	ENOG4108W2P	Methyl-accepting chemotaxis
HL653_RS01630	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HL653_RS01640	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HL653_RS01650	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HL653_RS01655	ENOG4105C3F	Signal peptidase i
HL653_RS01665	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HL653_RS01700	ENOG4105D7A	ATP-binding protein
HL653_RS01720	ENOG4107QJR	hflk protein
HL653_RS01725	ENOG4105D1F	ATP-binding protein
HL653_RS01730	ENOG4105K4P	CoA-binding domain protein
HL653_RS01740	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HL653_RS01745	ENOG4105KVH	Transcriptional regulator
HL653_RS01750	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HL653_RS01850	ENOG4105CW7	secretion protein, HlyD family
HL653_RS01855	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HL653_RS01870	ENOG410856B	UPF0235 protein
HL653_RS01885	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HL653_RS01890	ENOG4105DR5	peptidase
HL653_RS01895	ENOG4105ED9	Protein of unknown function (DUF455)
HL653_RS01900	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HL653_RS01905	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HL653_RS01925	ENOG41074H6	response regulator
HL653_RS01945	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HL653_RS01970	ENOG4105EN6	Membrane
HL653_RS01975	ENOG4107QRT	dEAD DEAH box helicase
HL653_RS01990	ENOG4105NVB	glycoside hydrolase, family 19
HL653_RS02050	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HL653_RS02055	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HL653_RS02065	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HL653_RS02075	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HL653_RS02090	ENOG4108RXX	maleylacetoacetate isomerase
HL653_RS02130	ENOG41082BR	50S ribosomal protein L35
HL653_RS02135	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HL653_RS02145	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HL653_RS02150	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HL653_RS02155	ENOG4105DWV	Homoserine O-trans-acetylase
HL653_RS02180	ENOG4105D6E	homoserine dehydrogenase
HL653_RS02205	ENOG4105CBT	Fructose-1,6-bisphosphatase
HL653_RS02210	ENOG4106KE4	Dehydrogenase
HL653_RS02220	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HL653_RS02225	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HL653_RS02240	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
HL653_RS02250	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HL653_RS02255	ENOG4105K5M	30s ribosomal protein S16
HL653_RS02260	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HL653_RS02285	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
HL653_RS02325	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HL653_RS02330	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HL653_RS02345	ENOG4107XZX	Involved in the transcription termination process (By similarity)
HL653_RS02355	ENOG4107VBH	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HL653_RS02365	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HL653_RS02400	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
HL653_RS02435	ENOG4105KDC	50s ribosomal protein l28
HL653_RS02465	ENOG4105XDF	Protein of unknown function (DUF1272)
HL653_RS02480	ENOG4105C7N	Xanthine uracil vitamin C permease
HL653_RS02485	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HL653_RS02495	ENOG4105C5R	Aminotransferase
HL653_RS02515	ENOG4105E1J	oxidoreductase
HL653_RS02520	ENOG4105VT2	5-hydroxyisourate hydrolase
HL653_RS02535	ENOG4107QUY	Guanine deaminase
HL653_RS02540	ENOG4105CQZ	Histidine kinase
HL653_RS02545	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HL653_RS02565	ENOG4105D52	delta-aminolevulinic acid dehydratase
HL653_RS02570	ENOG4105KNA	-acetyltransferase
HL653_RS02575	ENOG4108YYQ	gCN5-related N-acetyltransferase
HL653_RS02650	ENOG4107T65	Integrase
HL653_RS02665	ENOG4105EW9	transcriptional regulator AsnC family
HL653_RS02690	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HL653_RS02695	ENOG4105C9B	Cysteine desulfurase
HL653_RS02725	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HL653_RS02730	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HL653_RS02735	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HL653_RS02745	ENOG4105BZU	Histidine kinase
HL653_RS02750	ENOG4108JIR	Flagellum-specific ATP synthase
HL653_RS02775	ENOG4105DD5	Flagellar motor switch protein
HL653_RS02785	ENOG4105CN7	Flagellar biosynthetic protein FliP
HL653_RS02790	ENOG4105VS8	Flagellar biosynthetic protein fliq
HL653_RS02795	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HL653_RS02805	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HL653_RS02815	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HL653_RS02820	ENOG4105CUT	histidyl-tRNA synthetase
HL653_RS02825	ENOG4105F0N	pyrophosphate phospho-hydrolase
HL653_RS02840	ENOG4105ER2	Ompa motb domain protein
HL653_RS02845	ENOG4107RD7	Flagellar Motor Protein, MotA
HL653_RS02850	ENOG4105I03	Flagellin
HL653_RS02855	ENOG4105E1Q	flagellar hook-associated protein
HL653_RS02865	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HL653_RS02875	ENOG4105CGA	flagellar basal-body rod protein FlgG
HL653_RS02880	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HL653_RS02885	ENOG4105BZE	flagellar hook protein, FlgE
HL653_RS02890	ENOG4105W00	Flagellar hook capping protein
HL653_RS02895	ENOG4108ZC9	flagellar basal-body rod protein flgc
HL653_RS02905	ENOG4105E14	MotA TolQ exbB proton channel
HL653_RS02930	ENOG4105D7B	Flagellar biosynthesis protein flha
HL653_RS02935	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL653_RS02950	ENOG41067HS	methyltransferase
HL653_RS02960	ENOG4108WBT	adenosyltransferase
HL653_RS02970	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HL653_RS02980	ENOG4108KPJ	rna polymerase sigma factor
HL653_RS02985	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HL653_RS02990	ENOG4105CD8	aminopeptidase N
HL653_RS03005	ENOG4105C5W	Aldolase
HL653_RS03015	ENOG4105CAS	nag kinase
HL653_RS03025	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HL653_RS03035	ENOG41081FY	multiple antibiotic resistance (MarC)-related
HL653_RS03065	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HL653_RS03080	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HL653_RS03085	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
HL653_RS03090	ENOG4107Z5Z	endoribonuclease L-PSP
HL653_RS03095	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HL653_RS03100	ENOG4105CPU	Monooxygenase
HL653_RS03120	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HL653_RS03125	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HL653_RS03150	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HL653_RS03155	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HL653_RS03160	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HL653_RS03175	ENOG4105DVT	helicase
HL653_RS03250	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS03255	ENOG4105CBS	Chea signal transduction histidine kinase
HL653_RS03260	ENOG4105C8Q	Methyl-accepting chemotaxis
HL653_RS03270	ENOG4105BZU	Histidine kinase
HL653_RS03280	ENOG4105CWC	Acetylornithine deacetylase
HL653_RS03285	ENOG4107GRR	phosphate transport regulator
HL653_RS03290	ENOG4107QXV	Phosphate transporter
HL653_RS03295	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HL653_RS03335	ENOG4105DUX	Transporter
HL653_RS03370	ENOG4105D05	Receptor
HL653_RS03490	ENOG4106CY5	excisionase
HL653_RS03510	ENOG4105CPC	Aldo Keto reductase
HL653_RS03515	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
HL653_RS03520	ENOG4105C7W	Xanthine dehydrogenase
HL653_RS03525	ENOG4105C7W	Xanthine dehydrogenase
HL653_RS03530	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HL653_RS03535	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
HL653_RS03540	ENOG4105EQ2	LysR family Transcriptional regulator
HL653_RS03620	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL653_RS03670	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HL653_RS03695	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
HL653_RS03700	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HL653_RS03715	ENOG4105CJW	magnesium transporter
HL653_RS03745	ENOG4108VJ1	Transcriptional regulator (CarD family
HL653_RS03765	ENOG4105DR5	peptidase
HL653_RS03770	ENOG4108JJ7	ABC transporter
HL653_RS03780	ENOG4105DGW	oligopeptidase A
HL653_RS03785	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HL653_RS03790	ENOG4107U9T	Pfam:Ribonuclease_BN
HL653_RS03800	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HL653_RS03810	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HL653_RS03820	ENOG4108ZT0	50S ribosomal protein l17
HL653_RS03825	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL653_RS03840	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HL653_RS03845	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HL653_RS03850	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HL653_RS03855	ENOG4105EXC	Acyl-transferase
HL653_RS03860	ENOG41084HQ	50S ribosomal protein L30
HL653_RS03865	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HL653_RS03870	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HL653_RS03875	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HL653_RS03880	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HL653_RS03885	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HL653_RS03890	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL653_RS03895	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HL653_RS03900	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HL653_RS03905	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HL653_RS03915	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HL653_RS03920	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HL653_RS03925	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HL653_RS03930	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HL653_RS03935	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL653_RS03940	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HL653_RS03950	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HL653_RS03955	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HL653_RS03960	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HL653_RS03965	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HL653_RS03970	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HL653_RS03975	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HL653_RS04020	ENOG4105NAU	thioesterase Superfamily protein
HL653_RS04030	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HL653_RS04050	ENOG4108Z4V	iron-sulfur cluster assembly
HL653_RS04055	ENOG4105VG1	fes assembly suf system protein
HL653_RS04060	ENOG4105C9B	Cysteine desulfurase
HL653_RS04065	ENOG4105JRK	feS assembly protein SufD
HL653_RS04080	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HL653_RS04095	ENOG4105WD1	Membrane
HL653_RS04100	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HL653_RS04110	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HL653_RS04115	ENOG4108IQE	Amp-dependent synthetase and ligase
HL653_RS04125	ENOG4105EA8	2-Nitropropane dioxygenase
HL653_RS04135	ENOG4107835	probably involved in intracellular septation (By similarity)
HL653_RS04140	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HL653_RS04145	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL653_RS04150	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HL653_RS04155	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HL653_RS04170	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HL653_RS04175	ENOG4107U9T	Pfam:Ribonuclease_BN
HL653_RS04180	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HL653_RS04190	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HL653_RS04200	ENOG4105NPQ	Pfam:DUF403
HL653_RS04250	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HL653_RS04275	ENOG4108JJ6	Type I secretion system ATPase
HL653_RS04280	ENOG4107QZV	Type I secretion membrane fusion protein
HL653_RS04305	ENOG4107XZC	Restriction modification system DNA (Specificity
HL653_RS04390	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
HL653_RS04415	ENOG4105E4C	Lytic transglycosylase catalytic
HL653_RS04515	ENOG4105CHR	reductase
HL653_RS04520	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HL653_RS04525	ENOG4105CHR	reductase
HL653_RS04560	ENOG4105ECR	NmrA family
HL653_RS04565	ENOG4105KVH	Transcriptional regulator
HL653_RS04570	ENOG4105EG6	Saccharopine dehydrogenase
HL653_RS04600	ENOG4108NVR	Methyl-accepting chemotaxis
HL653_RS04605	ENOG4105D9N	nucleoside
HL653_RS04615	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HL653_RS04630	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HL653_RS04635	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HL653_RS04645	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL653_RS04650	ENOG4108IUZ	ABC transporter
HL653_RS04660	ENOG4107T8Q	Glycosyl transferase (Group 1
HL653_RS04665	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HL653_RS04670	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HL653_RS04685	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HL653_RS04690	ENOG410802X	bacteriophage n4 adsorption protein b
HL653_RS04700	ENOG4105C22	threonyL-tRNA synthetase
HL653_RS04715	ENOG41084X4	Acylphosphatase (EC 3.6.1.7)
HL653_RS04725	ENOG4105C10	Electron transfer flavoprotein
HL653_RS04730	ENOG4105BZJ	Electron transfer flavoprotein
HL653_RS04735	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HL653_RS04740	ENOG4105IJY	hydroxylase
HL653_RS04745	ENOG4105D3R	alkyl hydroperoxide reductase
HL653_RS04750	ENOG4108JU3	Alkyl hydroperoxide reductase
HL653_RS04755	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HL653_RS04760	ENOG4105MH3	Protein of unknown function (DUF2490)
HL653_RS04770	ENOG4108URH	decarboxylase
HL653_RS04795	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HL653_RS04805	ENOG4107ZT5	Thiol disulfide interchange protein
HL653_RS04810	ENOG4105CH7	arginosuccinase
HL653_RS04825	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HL653_RS04830	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HL653_RS04870	ENOG4105E0X	reductase
HL653_RS04875	ENOG4108JQC	penicillin-binding protein 1A
HL653_RS04885	ENOG4108ZZ3	UPF0260 protein
HL653_RS04910	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HL653_RS04915	ENOG4107TNS	sigma 54 modulation protein ribosomal protein S30ea
HL653_RS04925	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HL653_RS04930	ENOG4105E2X	shikimate dehydrogenase
HL653_RS04940	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HL653_RS04945	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HL653_RS04950	ENOG4108YXA	Membrane
HL653_RS04955	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HL653_RS04960	ENOG4108ZCF	integral membrane protein
HL653_RS04965	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HL653_RS04980	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HL653_RS04985	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HL653_RS04990	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
HL653_RS05015	ENOG4105C8T	Leucyl-tRNA synthetase
HL653_RS05020	ENOG4105TXM	Domain of unknown function (DUF3576)
HL653_RS05035	ENOG4105DFA	alanine racemase domain protein
HL653_RS05045	ENOG4107QJN	gtp cyclohydrolase ii
HL653_RS05050	ENOG4105CGK	Exodeoxyribonuclease III
HL653_RS05065	ENOG4105CNU	cell division protein FtsK
HL653_RS05080	ENOG4105DHJ	ABC, transporter
HL653_RS05100	ENOG4105CSM	endonuclease III
HL653_RS05115	ENOG4105CDH	Citrulline--aspartate ligase
HL653_RS05125	ENOG4105D3Q	Sugar transferase
HL653_RS05130	ENOG4108S0S	Nucleotidyl transferase
HL653_RS05135	ENOG4107SBE	Glycosyl transferase (Group 1
HL653_RS05140	ENOG4108TJN	glycosyl transferase group 1
HL653_RS05170	ENOG4105D75	Capsular exopolysaccharide family
HL653_RS05185	ENOG4105CV8	reductase
HL653_RS05190	ENOG4105D9R	oxidoreductase
HL653_RS05230	ENOG4105CPK	Glycosyl transferase (Group 1
HL653_RS05290	ENOG4105E51	psp operon transcriptional activator
HL653_RS05300	ENOG41087YS	Phage shock protein A
HL653_RS05350	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HL653_RS05355	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HL653_RS05360	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HL653_RS05365	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HL653_RS05380	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HL653_RS05385	ENOG4105WJX	transcriptional regulator MERR family
HL653_RS05390	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HL653_RS05395	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL653_RS05400	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HL653_RS05405	ENOG41082R8	50S ribosomal protein l32
HL653_RS05415	ENOG4105C5X	domain protein
HL653_RS05420	ENOG4105CRQ	synthase (Component I)
HL653_RS05430	ENOG4107U7B	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HL653_RS05440	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HL653_RS05445	ENOG4108Z03	MAF-like protein
HL653_RS05475	ENOG4108WIW	Aspartyl protease
HL653_RS05480	ENOG4107QPD	alcohol dehydrogenase
HL653_RS05490	ENOG4105C4W	S-formylglutathione hydrolase
HL653_RS05500	ENOG4105PGM	cation diffusion facilitator family transporter
HL653_RS05510	ENOG4105CH2	amidohydrolase
HL653_RS05520	ENOG4105DTS	flagellar hook-associated
HL653_RS05525	ENOG4105D00	flagellar biosynthetic protein flhB
HL653_RS05530	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HL653_RS05565	ENOG4105DFP	Integrase
HL653_RS05595	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HL653_RS05600	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HL653_RS05610	ENOG4105CF1	Alkylated DNA repair protein
HL653_RS05620	ENOG4105CBN	LysR family transcriptional regulator
HL653_RS05640	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HL653_RS05670	ENOG4105I4A	GCN5-related N-acetyltransferase
HL653_RS05690	ENOG4105JJR	Histidine kinase
HL653_RS05695	ENOG4105BZS	acriflavin resistance protein
HL653_RS05705	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS05715	ENOG4105CC0	LysR family Transcriptional regulator
HL653_RS05735	ENOG4105CPC	Aldo Keto reductase
HL653_RS05740	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HL653_RS05745	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL653_RS05765	ENOG4107SFI	Major Facilitator superfamily
HL653_RS05770	ENOG4105CPC	Aldo Keto reductase
HL653_RS05815	ENOG41061MD	high-affinity nickel-transporter
HL653_RS05820	ENOG4105VPX	protein, conserved in bacteria
HL653_RS05830	ENOG4107SET	aldo keto reductase
HL653_RS05835	ENOG4105C2C	drug resistance transporter, Bcr CflA
HL653_RS05850	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HL653_RS05855	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
HL653_RS05865	ENOG4105EQ2	LysR family Transcriptional regulator
HL653_RS05925	ENOG4108YXV	Transcriptional regulator
HL653_RS05940	ENOG4108YXV	Transcriptional regulator
HL653_RS05970	ENOG4105BZU	Histidine kinase
HL653_RS06030	ENOG4105CN7	Flagellar biosynthetic protein FliP
HL653_RS06035	ENOG410680W	Flagellar biosynthesis protein, FliO
HL653_RS06045	ENOG4108ZC9	flagellar basal-body rod protein flgc
HL653_RS06050	ENOG4105UVF	flagellar hook-basal body complex protein fliE
HL653_RS06060	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HL653_RS06065	ENOG4105D00	flagellar biosynthetic protein flhB
HL653_RS06070	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HL653_RS06075	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HL653_RS06110	ENOG4105IE4	repressor protein FlbT
HL653_RS06135	ENOG4107W75	Flagellin
HL653_RS06145	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HL653_RS06150	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HL653_RS06155	ENOG4108T1X	regulatory protein FlaEY
HL653_RS06160	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HL653_RS06170	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HL653_RS06175	ENOG4105DD5	Flagellar motor switch protein
HL653_RS06180	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL653_RS06185	ENOG4105D7B	Flagellar biosynthesis protein flha
HL653_RS06195	ENOG410822I	Flagellar hook capping protein
HL653_RS06205	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HL653_RS06215	ENOG4105CGA	flagellar basal-body rod protein FlgG
HL653_RS06220	ENOG4105KTQ	flagellar basal-body rod protein
HL653_RS06265	ENOG4105BZU	Histidine kinase
HL653_RS06270	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS06280	ENOG4108V3W	Chemotaxis protein, CheW
HL653_RS06290	ENOG41060XD	Flagellar protein FlaF
HL653_RS06295	ENOG4107RD7	Flagellar Motor Protein, MotA
HL653_RS06305	ENOG4108VYJ	response regulator receiver protein
HL653_RS06310	ENOG4105CBS	Chea signal transduction histidine kinase
HL653_RS06315	ENOG4108VYJ	response regulator receiver protein
HL653_RS06325	ENOG4105ER2	Ompa motb domain protein
HL653_RS06335	ENOG4108Z6B	deaminase
HL653_RS06340	ENOG4105BZU	Histidine kinase
HL653_RS06345	ENOG4105BZU	Histidine kinase
HL653_RS06350	ENOG4105BZU	Histidine kinase
HL653_RS06360	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HL653_RS06365	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HL653_RS06375	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HL653_RS06385	ENOG4105CN1	protease
HL653_RS06410	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HL653_RS06415	ENOG4105K46	50S ribosomal protein l27
HL653_RS06420	ENOG4105D9U	N-acetyltransferase
HL653_RS06425	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL653_RS06430	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HL653_RS06440	ENOG4105KUZ	arsenate reductase
HL653_RS06450	ENOG4107TE5	Lipid kinase
HL653_RS06460	ENOG4105BZU	Histidine kinase
HL653_RS06465	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HL653_RS06470	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HL653_RS06475	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HL653_RS06480	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HL653_RS06485	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HL653_RS06490	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HL653_RS06510	ENOG4105C3M	thioredoxin reductase
HL653_RS06535	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HL653_RS06560	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HL653_RS06565	ENOG4105BZS	acriflavin resistance protein
HL653_RS06575	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS06580	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HL653_RS06590	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HL653_RS06595	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HL653_RS06610	ENOG410901P	UPF0249 protein
HL653_RS06615	ENOG4105D4P	Coproporphyrinogen iii oxidase
HL653_RS06635	ENOG4105FBD	synthase
HL653_RS06640	ENOG4105FE1	phytoene synthase
HL653_RS06645	ENOG4107S11	squalene-associated FAD-dependent desaturase
HL653_RS06660	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL653_RS06675	ENOG410903C	(LipO)protein
HL653_RS06705	ENOG4107QX3	carboxylase
HL653_RS06725	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HL653_RS06745	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HL653_RS06750	ENOG4105KHC	sulfurtransferase
HL653_RS06755	ENOG4105C28	cystathionine
HL653_RS06795	ENOG41081HM	2'-5' rna ligase
HL653_RS06800	ENOG4105HFZ	Membrane
HL653_RS06805	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HL653_RS06815	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HL653_RS06820	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HL653_RS06825	ENOG4105CDY	transcriptional regulatory protein
HL653_RS06835	ENOG4105Y2X	UPF0335 protein
HL653_RS06840	ENOG4105EJQ	L-serine dehydratase
HL653_RS06845	ENOG4105DCF	alanine dehydrogenase
HL653_RS06855	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HL653_RS06875	ENOG4105C5H	ABC transporter
HL653_RS06885	ENOG4107T8Q	Glycosyl transferase (Group 1
HL653_RS06890	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HL653_RS06895	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HL653_RS06910	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HL653_RS06920	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HL653_RS06945	ENOG4107QJQ	Mate efflux family protein
HL653_RS06965	ENOG4105BZU	Histidine kinase
HL653_RS07005	ENOG4105C1J	atp-dependent rna helicase
HL653_RS07010	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HL653_RS07015	ENOG4108Z9K	Osmotically inducible protein
HL653_RS07070	ENOG4105VJY	transcriptional regulator
HL653_RS07095	ENOG4108UJD	30S ribosomal protein S9
HL653_RS07100	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HL653_RS07115	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HL653_RS07135	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HL653_RS07170	ENOG4105DG6	mannose-6-phosphate isomerase
HL653_RS07180	ENOG4108W6C	Dehydrogenase
HL653_RS07195	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HL653_RS07205	ENOG4105C2X	Arabinose 5-phosphate isomerase
HL653_RS07210	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HL653_RS07220	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HL653_RS07320	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HL653_RS07335	ENOG4108RDB	capsule polysaccharide export inner-membrane protein
HL653_RS07345	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HL653_RS07360	ENOG4105EV8	ectoine hydroxylase
HL653_RS07365	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HL653_RS07370	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HL653_RS07380	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HL653_RS07420	ENOG4107GD3	Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity)
HL653_RS07425	ENOG4107GD3	Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity)
HL653_RS07435	ENOG4105DTD	Dehydrogenase
HL653_RS07445	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HL653_RS07465	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HL653_RS07485	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HL653_RS07490	ENOG4105D8V	Glucose sorbosone dehydrogenase
HL653_RS07495	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HL653_RS07500	ENOG4108JQC	penicillin-binding protein 1A
HL653_RS07510	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
HL653_RS07520	ENOG4105C03	ribonuclease
HL653_RS07555	ENOG4105GVR	general secretion pathway protein D
HL653_RS07565	ENOG4105X5Z	General secretion pathway protein I
HL653_RS07575	ENOG4108VAU	general secretion pathway protein G
HL653_RS07590	ENOG4107QHF	type ii secretion system protein e
HL653_RS07595	ENOG4105D7Q	type ii secretion system
HL653_RS07610	ENOG4108WWZ	General secretion pathway protein J
HL653_RS07640	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HL653_RS07680	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL653_RS07685	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HL653_RS07700	ENOG4105M6F	mutator MutT protein
HL653_RS07710	ENOG41081UC	Inherit from COG: Competence protein
HL653_RS07760	ENOG4105E4I	Glycoside hydrolase family 28
HL653_RS07765	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS07785	ENOG4105ETE	Transcriptional regulator (LacI family
HL653_RS07790	ENOG4108UYB	regulatoR
HL653_RS07795	ENOG4105C08	Histidine kinase
HL653_RS07800	ENOG4108R6F	Surfeit locus 1 family protein
HL653_RS07805	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HL653_RS07810	ENOG4105CCU	oxidase (Subunit III)
HL653_RS07815	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HL653_RS07820	ENOG4105E2S	oxidase) subunit II
HL653_RS07825	ENOG4105CSH	Transporter
HL653_RS07840	ENOG4105F7F	Chaperone
HL653_RS07865	ENOG4105D05	Receptor
HL653_RS07875	ENOG4105C08	Histidine kinase
HL653_RS07890	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS07915	ENOG4105Y49	secretion protein, HlyD family
HL653_RS07925	ENOG4107Z11	Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity)
HL653_RS07935	ENOG4107RET	Isocitrate lyase
HL653_RS07945	ENOG4105C72	UPF0176 protein
HL653_RS07960	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HL653_RS07970	ENOG4107EJG	GntR family transcriptional regulator
HL653_RS07990	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HL653_RS08000	ENOG4108RTU	Aldolase
HL653_RS08025	ENOG4107EJG	GntR family transcriptional regulator
HL653_RS08035	ENOG4107QR9	Iron-sulfur cluster binding protein
HL653_RS08040	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HL653_RS08050	ENOG4107TDE	lipolytic protein G-D-S-L family
HL653_RS08055	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HL653_RS08060	ENOG4105J4Q	Transcriptional regulator
HL653_RS08065	ENOG4105CXK	mandelate racemase muconate lactonizing
HL653_RS08075	ENOG4106517	Short-chain dehydrogenase reductase Sdr
HL653_RS08085	ENOG4107YRA	Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity)
HL653_RS08120	ENOG4105DDI	hemolysin-type calcium-binding region
HL653_RS08125	ENOG4105F5H	Glycosyl Hydrolase Family 88
HL653_RS08135	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
HL653_RS08140	ENOG4105DDI	hemolysin-type calcium-binding region
HL653_RS08145	ENOG4107TDE	lipolytic protein G-D-S-L family
HL653_RS08175	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HL653_RS08180	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
HL653_RS08225	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HL653_RS08230	ENOG4105FDP	GntR family transcriptional regulator
HL653_RS08235	ENOG41069NU	Nitroreductase
HL653_RS08245	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL653_RS08250	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HL653_RS08255	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HL653_RS08265	ENOG4105DWF	phosphomethylpyrimidine kinase
HL653_RS08275	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HL653_RS08280	ENOG4105E0C	molybdate abc transporter
HL653_RS08285	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HL653_RS08310	ENOG4107QP3	malate synthase g
HL653_RS08320	ENOG4105X54	addiction module antidote protein
HL653_RS08325	ENOG4105KRP	Plasmid stabilization system
HL653_RS08335	ENOG4105EMN	RNA polymerase sigma factor
HL653_RS08350	ENOG4105DX0	Hemolysin A
HL653_RS08385	ENOG4108ETT	Dehydrogenase
HL653_RS08400	ENOG4105C08	Histidine kinase
HL653_RS08410	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HL653_RS08415	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HL653_RS08440	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HL653_RS08455	ENOG4105CNM	Receptor
HL653_RS08465	ENOG4105C6T	cysteine synthase
HL653_RS08480	ENOG4107YUR	Cell division protein mraZ
HL653_RS08485	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HL653_RS08510	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HL653_RS08530	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HL653_RS08535	ENOG4105DFU	Cell wall formation (By similarity)
HL653_RS08545	ENOG4105D4A	Cell wall formation (By similarity)
HL653_RS08555	ENOG4105CPF	Cell wall formation (By similarity)
HL653_RS08565	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HL653_RS08570	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HL653_RS08600	ENOG4105C75	arginyL-tRNA synthetase
HL653_RS08610	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HL653_RS08620	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HL653_RS08625	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HL653_RS08635	ENOG4105K89	arsenate reductase
HL653_RS08640	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HL653_RS08645	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HL653_RS08650	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HL653_RS08675	ENOG4105CSH	Transporter
HL653_RS08690	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HL653_RS08695	ENOG4105G9V	cytochrome C
HL653_RS08710	ENOG4105CEN	a g-specific adenine glycosylase
HL653_RS08730	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HL653_RS08745	ENOG4105CV8	reductase
HL653_RS08750	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
HL653_RS08760	ENOG4105DQ4	alcohol dehydrogenase
HL653_RS08765	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HL653_RS08770	ENOG4105DEN	Luciferase family
HL653_RS08775	ENOG4107ZSV	Receptor
HL653_RS08785	ENOG4105DT9	hydrolase family 43
HL653_RS08800	ENOG4105UYK	outer membrane protein a
HL653_RS08805	ENOG4107S1E	Beta-lactamase
HL653_RS08810	ENOG4105CSH	Transporter
HL653_RS08815	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL653_RS08830	ENOG4105C2M	dna polymerase I
HL653_RS08835	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HL653_RS08855	ENOG4105E66	phosphoriboisomerase A
HL653_RS08865	ENOG4108J5G	6-phosphogluconate dehydrogenase
HL653_RS08870	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HL653_RS08905	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HL653_RS08915	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HL653_RS08920	ENOG41090HR	transcriptional regulator
HL653_RS08940	ENOG4105D1H	recombination factor protein RarA
HL653_RS08960	ENOG4105CXG	d-lactate dehydrogenase
HL653_RS08980	ENOG4105TW1	Carbohydrate-selective porin OprB
HL653_RS09030	ENOG4105C26	Dehydrogenase
HL653_RS09055	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HL653_RS09060	ENOG4105W8H	transhydrogenase (subunit alpha
HL653_RS09065	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HL653_RS09070	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HL653_RS09080	ENOG4105CEC	DNA methylase N-4 N-6
HL653_RS09090	ENOG4105EEI	dihydropteroate synthase
HL653_RS09095	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HL653_RS09105	ENOG4105CPK	Glycosyl transferase (Group 1
HL653_RS09125	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL653_RS09130	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL653_RS09135	ENOG4108NVR	Methyl-accepting chemotaxis
HL653_RS09150	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HL653_RS09155	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HL653_RS09170	ENOG4105VEQ	Cold shock protein
HL653_RS09195	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HL653_RS09205	ENOG410642W	LysR family Transcriptional regulator
HL653_RS09210	ENOG4107S5I	aldo keto reductase
HL653_RS09230	ENOG41062BN	Preprotein translocase SecE subunit
HL653_RS09235	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HL653_RS09240	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HL653_RS09245	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HL653_RS09270	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HL653_RS09285	ENOG4108VZM	50s ribosomal protein L10
HL653_RS09290	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HL653_RS09300	ENOG4108YZS	Had-superfamily hydrolase, subfamily ia, variant 1
HL653_RS09310	ENOG4105C12	Phosphoribosylglycinamide synthetase
HL653_RS09330	ENOG4105Y3U	Transglycosylase-associated protein
HL653_RS09345	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HL653_RS09350	ENOG4107RKG	DJ-1/PfpI family
HL653_RS09355	ENOG4108YZA	Nitrogen regulatory protein pii
HL653_RS09360	ENOG4105C5F	glutamine synthetase
HL653_RS09370	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HL653_RS09375	ENOG4105BZU	Histidine kinase
HL653_RS09390	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HL653_RS09395	ENOG4105D07	Signal peptide peptidase, SppA
HL653_RS09405	ENOG4107S8C	mandelate racemase muconate lactonizing
HL653_RS09430	ENOG4107RNH	Outer membrane receptor FepA
HL653_RS09440	ENOG4105FC8	fad dependent oxidoreductase
HL653_RS09475	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HL653_RS09510	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HL653_RS09515	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HL653_RS09530	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HL653_RS09535	ENOG4105CEV	competence damage-inducible protein
HL653_RS09545	ENOG4105CYM	Glutathione S-transferase
HL653_RS09580	ENOG4105C2C	drug resistance transporter, Bcr CflA
HL653_RS09590	ENOG4105CFU	surface antigen
HL653_RS09630	ENOG4105BZ1	(ABC) transporter
HL653_RS09645	ENOG4107F9Y	LysR family transcriptional regulator
HL653_RS09650	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
HL653_RS09665	ENOG4108HRK	Histidine kinase
HL653_RS09675	ENOG4108ESX	Receptor
HL653_RS09690	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HL653_RS09700	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HL653_RS09725	ENOG4105GAK	amidohydrolase 2
HL653_RS09735	ENOG4105JSC	dimethylmenaquinone methyltransferase
HL653_RS09740	ENOG4105DDW	LysR family Transcriptional regulator
HL653_RS09750	ENOG4105KHM	amidohydrolase 2
HL653_RS09775	ENOG41072AC	4-hydroxybenzoate 3-monooxygenase
HL653_RS09780	ENOG4105CPC	Aldo Keto reductase
HL653_RS09790	ENOG4108D7R	p-hydroxycinnamoyl CoA hydratase lyase
HL653_RS09810	ENOG4108SC4	)-transporter
HL653_RS09815	ENOG4105D75	Capsular exopolysaccharide family
HL653_RS09835	ENOG410635A	Membrane
HL653_RS09840	ENOG4108UPT	UPF0178 protein
HL653_RS09845	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HL653_RS09865	ENOG4108ZNX	Heat shock protein
HL653_RS09885	ENOG4105CEY	Amp-dependent synthetase and ligase
HL653_RS09900	ENOG4105CHU	acetyl-coa acetyltransferase
HL653_RS09910	ENOG4105CSU	acyl-Coa dehydrogenase
HL653_RS09920	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HL653_RS09925	ENOG4105DHP	deoxycytidine triphosphate deaminase
HL653_RS09930	ENOG4105KG3	cytidine deaminase
HL653_RS09935	ENOG4108ZTZ	UPF0262 protein
HL653_RS09950	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HL653_RS09960	ENOG4107QHM	Sulfite reductase
HL653_RS09970	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HL653_RS09975	ENOG4105BZU	Histidine kinase
HL653_RS09985	ENOG4105CNG	UPF0061 protein
HL653_RS10000	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HL653_RS10005	ENOG4105C5I	Dehydrogenase
HL653_RS10010	ENOG4105DNH	Major Facilitator
HL653_RS10015	ENOG4105DP0	ferredoxin-NADP reductase
HL653_RS10030	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HL653_RS10045	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HL653_RS10055	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HL653_RS10130	ENOG4106UW1	Major Facilitator superfamily
HL653_RS10135	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL653_RS10140	ENOG4105BZU	Histidine kinase
HL653_RS10145	ENOG4105DJ0	Poly(A) Polymerase
HL653_RS10150	ENOG4105P8F	nudix hydrolase
HL653_RS10190	ENOG4105SG9	biopolymer transport protein, ExbD
HL653_RS10210	ENOG4105E32	cytoplasmic protein
HL653_RS10215	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HL653_RS10230	ENOG4105CPI	Metal Dependent Phosphohydrolase
HL653_RS10235	ENOG4105C4R	Atp-dependent dna helicase
HL653_RS10245	ENOG4105RK9	auxin efflux carrier
HL653_RS10250	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HL653_RS10255	ENOG4105CFF	transcriptional regulator
HL653_RS10270	ENOG4105CH6	catalase
HL653_RS10280	ENOG4107TSN	permease
HL653_RS10300	ENOG4105K34	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound
HL653_RS10320	ENOG4105CA0	peroxidase
HL653_RS10330	ENOG4105D05	Receptor
HL653_RS10350	ENOG4107ZSV	Receptor
HL653_RS10365	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HL653_RS10390	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
HL653_RS10400	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HL653_RS10405	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HL653_RS10430	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HL653_RS10435	ENOG4108KEZ	Dehydrogenase
HL653_RS10455	ENOG4108IIH	CoA-transferase subunit B
HL653_RS10465	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HL653_RS10510	ENOG4107ZSV	Receptor
HL653_RS10515	ENOG4105ERH	Fumarylacetoacetate hydrolase
HL653_RS10520	ENOG4105D2S	major facilitator superfamily
HL653_RS10545	ENOG41069M3	Transcriptional regulator
HL653_RS10555	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HL653_RS10560	ENOG4105EUB	pirin domain protein
HL653_RS10605	ENOG4108RXX	maleylacetoacetate isomerase
HL653_RS10625	ENOG4105EIK	Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity)
HL653_RS10635	ENOG4105EEQ	Na H antiporter
HL653_RS10640	ENOG4108KF1	Membrane
HL653_RS10655	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HL653_RS10705	ENOG4105ENX	hydrolase
HL653_RS10710	ENOG4107RTG	Major Facilitator superfamily
HL653_RS10715	ENOG4105EQ2	LysR family Transcriptional regulator
HL653_RS10745	ENOG41081FY	multiple antibiotic resistance (MarC)-related
HL653_RS10760	ENOG4105VN1	Heat shock protein
HL653_RS10765	ENOG4108ZNX	Heat shock protein
HL653_RS10785	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS10790	ENOG4105RAK	Histidine kinase
HL653_RS10795	ENOG4105BZU	Histidine kinase
HL653_RS10835	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS10865	ENOG4105EQ2	LysR family Transcriptional regulator
HL653_RS10870	ENOG4105DZG	Dehydrogenase
HL653_RS10910	ENOG4105DY9	regulatoR
HL653_RS10920	ENOG4107S1E	Beta-lactamase
HL653_RS10940	ENOG4105HEI	LysR family (Transcriptional regulator
HL653_RS10955	ENOG410804D	Sensor Signal Transduction Histidine Kinase
HL653_RS10970	ENOG4105EQ2	LysR family Transcriptional regulator
HL653_RS10975	ENOG4105D74	hydrolase
HL653_RS10980	ENOG4108594	Permease of the drug metabolite transporter
HL653_RS10990	ENOG4105CIR	epoxide hydrolase
HL653_RS10995	ENOG4105T0Z	Conserved Protein
HL653_RS11000	ENOG4108J2P	Alpha beta hydrolase fold
HL653_RS11005	ENOG4105KVH	Transcriptional regulator
HL653_RS11010	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
HL653_RS11040	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HL653_RS11080	ENOG4105C26	Dehydrogenase
HL653_RS11090	ENOG4105E3B	Multicopper oxidase
HL653_RS11110	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HL653_RS11115	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HL653_RS11120	ENOG4105BZU	Histidine kinase
HL653_RS11180	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HL653_RS11190	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HL653_RS11195	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HL653_RS11210	ENOG41081R2	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HL653_RS11225	ENOG4107WCG	it plays a direct role in the translocation of protons across the membrane (By similarity)
HL653_RS11235	ENOG4108Q71	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HL653_RS11240	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HL653_RS11275	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HL653_RS11285	ENOG41067SE	Tetr family transcriptional regulator
HL653_RS11290	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS11305	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HL653_RS11310	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL653_RS11315	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HL653_RS11325	ENOG4105DQ4	alcohol dehydrogenase
HL653_RS11340	ENOG4105DJB	Major Facilitator Superfamily
HL653_RS11345	ENOG4105CXK	mandelate racemase muconate lactonizing
HL653_RS11365	ENOG4105EBR	Carboxylesterase
HL653_RS11370	ENOG4105EBR	Carboxylesterase
HL653_RS11410	ENOG4105ETE	Transcriptional regulator (LacI family
HL653_RS11415	ENOG4105CT4	transporter
HL653_RS11450	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL653_RS11475	ENOG4107EJG	GntR family transcriptional regulator
HL653_RS11485	ENOG4105CXK	mandelate racemase muconate lactonizing
HL653_RS11490	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HL653_RS11515	ENOG4105EI3	2-dehydro-3-deoxygalactonokinase EC 2.7.1.58
HL653_RS11530	ENOG4105EQR	Transposase IS116 IS110 IS902
HL653_RS11550	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HL653_RS11555	ENOG4107W9I	Creatinine amidohydrolase
HL653_RS11560	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS11565	ENOG4105DUM	transcriptional regulator, lysR family
HL653_RS11570	ENOG4108Q27	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)
HL653_RS11595	ENOG4105NTK	Transcriptional repressor Mpra
HL653_RS11615	ENOG4107ZSV	Receptor
HL653_RS11620	ENOG4105EBR	Carboxylesterase
HL653_RS11655	ENOG4105D63	family UPF0324
HL653_RS11695	ENOG4107R11	Transcriptional regulator
HL653_RS11755	ENOG4105CA9	Pyruvate kinase
HL653_RS11760	ENOG4106IPI	cyclase, family
HL653_RS11770	ENOG4105D05	Receptor
HL653_RS11775	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HL653_RS11795	ENOG4105DAA	L-lactate
HL653_RS11920	ENOG4105CJW	magnesium transporter
HL653_RS11930	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
HL653_RS11935	ENOG4105C7W	Xanthine dehydrogenase
HL653_RS11940	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
HL653_RS11945	ENOG4105C7W	Xanthine dehydrogenase
HL653_RS11950	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HL653_RS11955	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
HL653_RS11960	ENOG4107XAN	XdhC and CoxI family
HL653_RS11965	ENOG4107RTG	Major Facilitator superfamily
HL653_RS11975	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HL653_RS11980	ENOG4105D8V	Glucose sorbosone dehydrogenase
HL653_RS11995	ENOG4105BZU	Histidine kinase
HL653_RS12005	ENOG4108C33	Resolvase
HL653_RS12030	ENOG4108YXQ	IS66 Orf2 family protein
HL653_RS12040	ENOG4105KAK	Plasmid pRiA4b ORF-3 family protein
HL653_RS12075	ENOG4105KT7	mgtC SapB transporter
HL653_RS12085	ENOG4105ECQ	AraC Family Transcriptional Regulator
HL653_RS12270	ENOG4105TCH	Asparagine synthase
HL653_RS12445	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL653_RS12490	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HL653_RS12495	ENOG410856B	UPF0235 protein
HL653_RS12585	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HL653_RS12590	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL653_RS12655	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HL653_RS12675	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HL653_RS12680	ENOG4105BZU	Histidine kinase
HL653_RS12690	ENOG4105CD8	aminopeptidase N
HL653_RS12710	ENOG4105CQ7	ATP-dependent helicase
HL653_RS12725	ENOG4107104	thymidine kinase
HL653_RS12735	ENOG4105EAH	synthase
HL653_RS12740	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
HL653_RS12770	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HL653_RS12810	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HL653_RS12820	ENOG4105F7P	transcriptional regulator AsnC family
HL653_RS12840	ENOG4105CPC	Aldo Keto reductase
HL653_RS12845	ENOG4105HEI	LysR family (Transcriptional regulator
HL653_RS12850	ENOG4105CN2	monooxygenase, FAD-binding
HL653_RS12855	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HL653_RS12910	ENOG4105D05	Receptor
HL653_RS12915	ENOG4106KE4	Dehydrogenase
HL653_RS12920	ENOG4105CXK	mandelate racemase muconate lactonizing
HL653_RS12925	ENOG4105DPW	Major facilitator superfamily MFS_1
HL653_RS12940	ENOG4105EEQ	Na H antiporter
HL653_RS12980	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
HL653_RS12985	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HL653_RS12990	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HL653_RS13020	ENOG4105E3B	Multicopper oxidase
HL653_RS13050	ENOG4107VZS	Nicotinamide-nucleotide adenylyltransferase
HL653_RS13065	ENOG4105CNM	Receptor
HL653_RS13080	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HL653_RS13090	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS13100	ENOG4105DGU	Histone deacetylase
HL653_RS13105	ENOG4105CQZ	Histidine kinase
HL653_RS13110	ENOG4108IYU	L-aspartate oxidase
HL653_RS13120	ENOG4105DA5	(ABC) transporter
HL653_RS13135	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HL653_RS13140	ENOG4108YZA	Nitrogen regulatory protein pii
HL653_RS13145	ENOG4105BZU	Histidine kinase
HL653_RS13150	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HL653_RS13165	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HL653_RS13170	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HL653_RS13185	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HL653_RS13205	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HL653_RS13210	ENOG4105C9M	aspartyl-trna synthetase
HL653_RS13215	ENOG4105CSR	polyphosphate kinase 2
HL653_RS13220	ENOG4108RRZ	Transcription elongation factor GreB
HL653_RS13225	ENOG4105E4C	Lytic transglycosylase catalytic
HL653_RS13230	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HL653_RS13235	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HL653_RS13245	ENOG41074H6	response regulator
HL653_RS13255	ENOG4105CSH	Transporter
HL653_RS13260	ENOG4106H78	methyltransferase
HL653_RS13265	ENOG4105FE9	pseudouridine synthase
HL653_RS13295	ENOG4105C83	adenylosuccinate lyase
HL653_RS13305	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HL653_RS13310	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
HL653_RS13315	ENOG4106TD9	Diguanylate cyclase
HL653_RS13330	ENOG4105CYM	Glutathione S-transferase
HL653_RS13355	ENOG4108VRQ	UPF0314 protein
HL653_RS13380	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HL653_RS13390	ENOG4105EI2	Pseudouridine synthase
HL653_RS13395	ENOG41082CG	Protein CrcB homolog
HL653_RS13435	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HL653_RS13450	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HL653_RS13455	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HL653_RS13460	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HL653_RS13470	ENOG4105D6F	Phosphatase
HL653_RS13485	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HL653_RS13510	ENOG4107QN2	dihydrolipoyl dehydrogenase
HL653_RS13520	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HL653_RS13530	ENOG4105FKN	transcriptional regulator, AsnC family
HL653_RS13550	ENOG4108VHC	Short-chain dehydrogenase reductase Sdr
HL653_RS13555	ENOG4105KVH	Transcriptional regulator
HL653_RS13565	ENOG4107S78	Band 7 protein
HL653_RS13575	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HL653_RS13580	ENOG4105CKW	Inner membrane protein yedI
HL653_RS13620	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS13635	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HL653_RS13640	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HL653_RS13660	ENOG4108MFN	small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex)
HL653_RS13665	ENOG4106FI7	cytochrome c-type biogenesis protein
HL653_RS13670	ENOG4105MIR	Phenylalanine 4-monooxygenase
HL653_RS13680	ENOG4105D7W	serine acetyltransferase
HL653_RS13705	ENOG4105NA0	Transcriptional regulator
HL653_RS13720	ENOG4105E0F	Histidine kinase
HL653_RS13725	ENOG4105EQ2	LysR family Transcriptional regulator
HL653_RS13755	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HL653_RS13760	ENOG4105K63	Thioredoxin
HL653_RS13775	ENOG4108733	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HL653_RS13790	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HL653_RS13800	ENOG4105W5Q	DNA repair protein (RadC
HL653_RS13825	ENOG4105EB3	Histidine kinase
HL653_RS13835	ENOG4107R0V	Pyruvate dehydrogenase
HL653_RS13840	ENOG4105CPP	Dehydrogenase, E1 component
HL653_RS13845	ENOG4107QSN	dihydrolipoamide acetyltransferase
HL653_RS13850	ENOG4105CS9	pantothenic acid kinase
HL653_RS13855	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HL653_RS13860	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HL653_RS13865	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HL653_RS13900	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HL653_RS13915	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HL653_RS13920	ENOG4107Y2H	ErfK ybiS ycfS ynhG family protein
HL653_RS13940	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HL653_RS13945	ENOG4105ECY	inositol monophosphatase
HL653_RS13950	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HL653_RS13955	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL653_RS13960	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HL653_RS13965	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL653_RS13985	ENOG4107QIZ	NADH dehydrogenase
HL653_RS13990	ENOG4108IEH	NADH dehydrogenase subunit g
HL653_RS13995	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HL653_RS14000	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL653_RS14005	ENOG4105DF2	NADH dehydrogenase subunit j
HL653_RS14010	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL653_RS14015	ENOG4105D65	subunit l
HL653_RS14020	ENOG4105C8S	subunit m
HL653_RS14025	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL653_RS14030	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HL653_RS14035	ENOG4105EN6	Membrane
HL653_RS14045	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS14050	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HL653_RS14065	ENOG4105EA8	2-Nitropropane dioxygenase
HL653_RS14075	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HL653_RS14080	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HL653_RS14115	ENOG4105C5H	ABC transporter
HL653_RS14125	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HL653_RS14130	ENOG4105IFJ	Histidine kinase
HL653_RS14145	ENOG4105CHH	sulfate transporter
HL653_RS14150	ENOG4107B2H	carbonic anhydrase
HL653_RS14155	ENOG410804D	Sensor Signal Transduction Histidine Kinase
HL653_RS14160	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HL653_RS14170	ENOG4105HEI	LysR family (Transcriptional regulator
HL653_RS14175	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HL653_RS14180	ENOG4107VGR	Catalase
HL653_RS14185	ENOG4105CPW	cytochrome b561
HL653_RS14210	ENOG4105EFZ	amidohydrolase
HL653_RS14225	ENOG4108W2Y	isochorismatase
HL653_RS14245	ENOG4105E2R	ROK family
HL653_RS14250	ENOG4105EQ0	Major Facilitator superfamily
HL653_RS14290	ENOG4107ZSV	Receptor
HL653_RS14295	ENOG4105GVF	(ABC) transporter
HL653_RS14300	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
HL653_RS14310	ENOG4108DBC	nitroreductase
HL653_RS14315	ENOG4105D4R	Catalyzes the desulfonation of aliphatic sulfonates (By similarity)
HL653_RS14330	ENOG4105EMU	Dehydrogenase
HL653_RS14335	ENOG4105CPC	Aldo Keto reductase
HL653_RS14345	ENOG4105EEQ	Na H antiporter
HL653_RS14350	ENOG4105CEP	NADH dehydrogenase
HL653_RS14365	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HL653_RS14370	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
HL653_RS14375	ENOG4108Z0R	Transferase
HL653_RS14385	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HL653_RS14390	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HL653_RS14395	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HL653_RS14400	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HL653_RS14405	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HL653_RS14410	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HL653_RS14420	ENOG4108MJ5	VirK protein
HL653_RS14425	ENOG4105C25	Primosomal protein n'
HL653_RS14435	ENOG4105BZN	citrate synthase
HL653_RS14440	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HL653_RS14445	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HL653_RS14450	ENOG4105CQZ	Histidine kinase
HL653_RS14455	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HL653_RS14465	ENOG4108RU0	short-chain dehydrogenase reductase
HL653_RS14475	ENOG4105DSF	transport protein
HL653_RS14525	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HL653_RS14540	ENOG4105BZA	Phosphoglycerate kinase
HL653_RS14555	ENOG4105WYW	fructose-bisphosphate aldolase
HL653_RS14565	ENOG4106HMZ	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HL653_RS14590	ENOG4105CUB	amino acid
HL653_RS14605	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HL653_RS14615	ENOG4105VC4	domain protein
HL653_RS14620	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HL653_RS14625	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HL653_RS14630	ENOG4108YZG	isomerase
HL653_RS14645	ENOG4105D6Z	AFG1 family ATPase
HL653_RS14660	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HL653_RS14670	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HL653_RS14680	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HL653_RS14695	ENOG4105CNI	cell division protein FtsW
HL653_RS14710	ENOG4107MBT	Plasmid stabilisation system protein
HL653_RS14720	ENOG4105CBS	Chea signal transduction histidine kinase
HL653_RS14725	ENOG4105BZU	Histidine kinase
HL653_RS14730	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS14740	ENOG4108VYJ	response regulator receiver protein
HL653_RS14750	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS14755	ENOG4108V3W	Chemotaxis protein, CheW
HL653_RS14765	ENOG4105BZU	Histidine kinase
HL653_RS14785	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HL653_RS14795	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL653_RS14830	ENOG4106CY5	excisionase
HL653_RS14980	ENOG4108HRK	Histidine kinase
HL653_RS14985	ENOG4108NEV	two component transcriptional regulator, LytTR family
HL653_RS14990	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HL653_RS15000	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL653_RS15010	ENOG4105BZU	Histidine kinase
HL653_RS15015	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HL653_RS15020	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HL653_RS15025	ENOG4105BZU	Histidine kinase
HL653_RS15045	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HL653_RS15060	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HL653_RS15065	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HL653_RS15105	ENOG4105C31	Tryptophanyl-tRNA synthetase
HL653_RS15115	ENOG4105CJR	Integral membrane protein (MviN
HL653_RS15120	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HL653_RS15130	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HL653_RS15140	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HL653_RS15145	ENOG4108TGY	Glutathione S-transferase
HL653_RS15155	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HL653_RS15165	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HL653_RS15170	ENOG41067YR	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HL653_RS15175	ENOG4105VG0	50S ribosomal protein l34
HL653_RS15185	ENOG4105C0P	Mg chelatase subunit ChlI
HL653_RS15190	ENOG4105KAF	membrAne
HL653_RS15200	ENOG4105EUJ	GTP cyclohydrolase i
HL653_RS15210	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HL653_RS15230	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS15240	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HL653_RS15265	ENOG4105C5I	Dehydrogenase
HL653_RS15280	ENOG4105HEI	LysR family (Transcriptional regulator
HL653_RS15300	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HL653_RS15305	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HL653_RS15310	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HL653_RS15320	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HL653_RS15345	ENOG4105CGZ	zinc metallopeptidase
HL653_RS15360	ENOG4105K6V	RNA polymerase
HL653_RS15415	ENOG4105D44	asparaginase
HL653_RS15435	ENOG4105TW1	Carbohydrate-selective porin OprB
HL653_RS15460	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HL653_RS15470	ENOG4108RM3	Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo
HL653_RS15475	ENOG4105KVH	Transcriptional regulator
HL653_RS15480	ENOG4105ECR	NmrA family
HL653_RS15490	ENOG4105F27	Major Facilitator
HL653_RS15500	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HL653_RS15505	ENOG4105K70	DNA-binding protein
HL653_RS15520	ENOG4105CHU	acetyl-coa acetyltransferase
HL653_RS15525	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HL653_RS15545	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HL653_RS15560	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HL653_RS15575	ENOG4105DJP	Membrane
HL653_RS15580	ENOG41060IM	Heme exporter protein
HL653_RS15590	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HL653_RS15595	ENOG4105DA4	cytochrome c-type biogenesis protein
HL653_RS15605	ENOG4105KWW	Biogenesis protein
HL653_RS15620	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HL653_RS15625	ENOG4105C8U	phosphate abc transporter
HL653_RS15630	ENOG4105E2Z	phosphate ABC transporter (Permease
HL653_RS15665	ENOG4107RCQ	(CBS) domain
HL653_RS15670	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HL653_RS15685	ENOG4105C9A	Phoh family
HL653_RS15690	ENOG4105E0X	reductase
HL653_RS15700	ENOG4108IUX	(ABC) transporter
HL653_RS15705	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HL653_RS15715	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HL653_RS15725	ENOG4105EDK	PfkB domain protein
HL653_RS15730	ENOG4105CUB	amino acid
HL653_RS15735	ENOG4105K59	histidine triad (HIT) protein
HL653_RS15740	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
HL653_RS15745	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HL653_RS15750	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
HL653_RS15780	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HL653_RS15785	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HL653_RS15790	ENOG4105CAT	Cytidine monophosphate kinase
HL653_RS15800	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HL653_RS15840	ENOG4105EGS	Mechanosensitive ion channel
HL653_RS15850	ENOG4105C4C	beta-galactosidase
HL653_RS15870	ENOG4105DZG	Dehydrogenase
HL653_RS15890	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HL653_RS15895	ENOG4105DZG	Dehydrogenase
HL653_RS15900	ENOG4105DZG	Dehydrogenase
HL653_RS15915	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HL653_RS15920	ENOG4105E39	Enoyl-CoA hydratase
HL653_RS15925	ENOG4105DMF	Dehydrogenase
HL653_RS15930	ENOG4105DJB	Major Facilitator Superfamily
HL653_RS15935	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL653_RS15945	ENOG4108PC0	lipolytic protein G-D-S-L family
HL653_RS15965	ENOG4105ETE	Transcriptional regulator (LacI family
HL653_RS15975	ENOG4105PNM	synthesis protein
HL653_RS15985	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS16000	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HL653_RS16010	ENOG4108MUZ	hydrolase
HL653_RS16020	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS16025	ENOG4108I5G	Major Facilitator superfamily
HL653_RS16050	ENOG4105DZG	Dehydrogenase
HL653_RS16055	ENOG4105EXG	Transcriptional regulator
HL653_RS16085	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL653_RS16090	ENOG4105DHQ	Histidine kinase
HL653_RS16125	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS16140	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HL653_RS16155	ENOG4105DDC	Oxidoreductase domain protein
HL653_RS16165	ENOG4105F5H	Glycosyl Hydrolase Family 88
HL653_RS16225	ENOG4105D4P	Coproporphyrinogen iii oxidase
HL653_RS16230	ENOG4108JJ8	(ABC) transporter
HL653_RS16235	ENOG4108JJ9	ABC, transporter
HL653_RS16240	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HL653_RS16245	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HL653_RS16255	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HL653_RS16275	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HL653_RS16290	ENOG4105BZP	glycoside hydrolase 15-related
HL653_RS16300	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HL653_RS16310	ENOG4105ETE	Transcriptional regulator (LacI family
HL653_RS16345	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HL653_RS16350	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HL653_RS16355	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HL653_RS16360	ENOG4105E98	transcriptional regulator DeoR family
HL653_RS16365	ENOG4105DPW	Major facilitator superfamily MFS_1
HL653_RS16375	ENOG4107ZSV	Receptor
HL653_RS16400	ENOG4107YCY	Transcriptional regulator
HL653_RS16410	ENOG4105DSG	hydrolase family 43
HL653_RS16450	ENOG4107QI1	Mate efflux family protein
HL653_RS16455	ENOG4105CSV	Glutaminase
HL653_RS16460	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
HL653_RS16500	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HL653_RS16505	ENOG4105EHG	Permease protein
HL653_RS16565	ENOG4105DQE	DNA ligase
HL653_RS16570	ENOG4105FDF	Could be involved in DNA repair (By similarity)
HL653_RS16575	ENOG4105CNT	hydrolase family 2
HL653_RS16580	ENOG4106KED	esterase YpfH
HL653_RS16585	ENOG4105CHF	Glutathione S-transferase
HL653_RS16595	ENOG4105DS1	cytochrome b561
HL653_RS16600	ENOG4108YYC	ycei family
HL653_RS16605	ENOG4105EJC	lysr family transcriptional regulator
HL653_RS16610	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HL653_RS16615	ENOG4105DAA	L-lactate
HL653_RS16625	ENOG4105EJC	lysr family transcriptional regulator
HL653_RS16640	ENOG4105C26	Dehydrogenase
HL653_RS16645	ENOG4105C1G	acyl-Coa dehydrogenase
HL653_RS16650	ENOG4105CGU	Enoyl-CoA hydratase
HL653_RS16665	ENOG4105BZU	Histidine kinase
HL653_RS16685	ENOG4105BZU	Histidine kinase
HL653_RS16695	ENOG4105DQE	DNA ligase
HL653_RS16700	ENOG4105FDF	Could be involved in DNA repair (By similarity)
HL653_RS16720	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HL653_RS16725	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HL653_RS16735	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HL653_RS16745	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HL653_RS16800	ENOG4105CYW	agmatinase
HL653_RS16820	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
HL653_RS16830	ENOG4105DJ2	Major Facilitator Superfamily
HL653_RS16855	ENOG4105C8Q	Methyl-accepting chemotaxis
HL653_RS16865	ENOG4105CK5	oxidoreductase
HL653_RS16870	ENOG4105BZP	glycoside hydrolase 15-related
HL653_RS16880	ENOG4107FW0	short-chain dehydrogenase reductase
HL653_RS16895	ENOG4105DQ4	alcohol dehydrogenase
HL653_RS16910	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL653_RS16920	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL653_RS16945	ENOG4105ETE	Transcriptional regulator (LacI family
HL653_RS16955	ENOG4105CPC	Aldo Keto reductase
HL653_RS16960	ENOG4105CPN	adenine deaminase
HL653_RS16965	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HL653_RS16970	ENOG4105DZG	Dehydrogenase
HL653_RS16980	ENOG4105FQP	Beta-lactamase
HL653_RS16990	ENOG4105D05	Receptor
HL653_RS17005	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HL653_RS17025	ENOG4105CPT	Alpha beta hydrolase
HL653_RS17030	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HL653_RS17055	ENOG4108KTU	conserved protein with FAD NAD(P)-binding domain
HL653_RS17075	ENOG4105C7W	Xanthine dehydrogenase
HL653_RS17080	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HL653_RS17085	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
HL653_RS17105	ENOG4105CV8	reductase
HL653_RS17110	ENOG4105CWX	Alpha-1,2-mannosidase
HL653_RS17150	ENOG4105F4G	Membrane
HL653_RS17165	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HL653_RS17215	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HL653_RS17220	ENOG4105C7W	Xanthine dehydrogenase
HL653_RS17230	ENOG4105BZU	Histidine kinase
HL653_RS17235	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
HL653_RS17250	ENOG4105DZG	Dehydrogenase
HL653_RS17275	ENOG4105DJB	Major Facilitator Superfamily
HL653_RS17285	ENOG4105R1U	AraC Family Transcriptional Regulator
HL653_RS17305	ENOG4108IG5	Transcriptional regulator
HL653_RS17320	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HL653_RS17325	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HL653_RS17340	ENOG4105DDI	hemolysin-type calcium-binding region
HL653_RS17390	ENOG4105CF7	AraC family transcriptional regulator
HL653_RS17410	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HL653_RS17415	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HL653_RS17425	ENOG4105CC0	LysR family Transcriptional regulator
HL653_RS17435	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HL653_RS17450	ENOG4105EQ2	LysR family Transcriptional regulator
HL653_RS17455	ENOG4105CIR	epoxide hydrolase
HL653_RS17470	ENOG410903D	sensor protein
HL653_RS17475	ENOG4105CQZ	Histidine kinase
HL653_RS17480	ENOG4107S1E	Beta-lactamase
HL653_RS17505	ENOG4108XEP	Alpha Beta Hydrolase Fold protein
HL653_RS17515	ENOG4107XII	Glycosyl Hydrolase Family 88
HL653_RS17545	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS17585	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HL653_RS17600	ENOG4108IRC	dna polymerase iii
HL653_RS17610	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HL653_RS17620	ENOG4105C3M	thioredoxin reductase
HL653_RS17685	ENOG4105K70	DNA-binding protein
HL653_RS17690	ENOG41063JG	Transcriptional regulator
HL653_RS17715	ENOG4108YXV	Transcriptional regulator
HL653_RS17735	ENOG4108JQC	penicillin-binding protein 1A
HL653_RS17780	ENOG4105C8Q	Methyl-accepting chemotaxis
HL653_RS17785	ENOG4105YVF	chew protein
HL653_RS17790	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS17795	ENOG4105BZU	Histidine kinase
HL653_RS17800	ENOG4105CBS	Chea signal transduction histidine kinase
HL653_RS17860	ENOG4105C7I	Dehydrogenase
HL653_RS17865	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HL653_RS17870	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HL653_RS17885	ENOG4105ECY	inositol monophosphatase
HL653_RS17920	ENOG4106BRA	Membrane
HL653_RS17935	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HL653_RS17940	ENOG4105CHR	reductase
HL653_RS17945	ENOG4107SDU	Methyl-accepting chemotaxis
HL653_RS17950	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
HL653_RS17980	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
HL653_RS17995	ENOG4105CPN	adenine deaminase
HL653_RS18005	ENOG4105CF7	AraC family transcriptional regulator
HL653_RS18010	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HL653_RS18025	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HL653_RS18030	ENOG4108Z1B	Cyclase dehydrase
HL653_RS18035	ENOG4105CEV	competence damage-inducible protein
HL653_RS18045	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HL653_RS18070	ENOG4105ES5	Histidine kinase
HL653_RS18075	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL653_RS18080	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HL653_RS18085	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HL653_RS18100	ENOG4105DXN	mazG family
HL653_RS18110	ENOG4105NCT	RNA Polymerase
HL653_RS18130	ENOG4105HEI	LysR family (Transcriptional regulator
HL653_RS18145	ENOG4105F8V	Hydrolase, tatD family
HL653_RS18165	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HL653_RS18170	ENOG4105DZ1	carboxypeptidase
HL653_RS18180	ENOG4105DJV	ribulose-phosphate 3-epimerase
HL653_RS18190	ENOG410903C	(LipO)protein
HL653_RS18195	ENOG41082BM	Transcriptional regulator, arsr family
HL653_RS18200	ENOG4105SYT	Methylenetetrahydrofolate reductase
HL653_RS18205	ENOG4105C3R	Methionine synthase
HL653_RS18210	ENOG4105C3R	Methionine synthase
HL653_RS18225	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HL653_RS18240	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HL653_RS18245	ENOG4105C7B	Threonine dehydratase
HL653_RS18250	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HL653_RS18255	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HL653_RS18280	ENOG4108KPZ	tonB-dependent Receptor
HL653_RS18295	ENOG4105DHJ	ABC, transporter
HL653_RS18305	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HL653_RS18330	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
HL653_RS18340	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HL653_RS18350	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS18360	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HL653_RS18380	ENOG4107QP8	phosphohexose isomerase
HL653_RS18385	ENOG4105C3F	Signal peptidase i
HL653_RS18425	ENOG4105E3A	(ABC) transporter
HL653_RS18440	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL653_RS18455	ENOG4105NWN	ApaG protein
HL653_RS18465	ENOG4108V06	Glutathione peroxidase
HL653_RS18475	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HL653_RS18495	ENOG4105DZ0	fad dependent oxidoreductase
HL653_RS18505	ENOG4105ED2	Beta-lactamase
HL653_RS18510	ENOG4107ZSV	Receptor
HL653_RS18550	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HL653_RS18555	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HL653_RS18565	ENOG4105CPF	Cell wall formation (By similarity)
HL653_RS18575	ENOG4105CKB	glycosidase
HL653_RS18580	ENOG4105JNK	Glycosyl transferase (Group 1
HL653_RS18605	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL653_RS18610	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL653_RS18615	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HL653_RS18620	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HL653_RS18630	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HL653_RS18640	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HL653_RS18645	ENOG4105FC8	fad dependent oxidoreductase
HL653_RS18700	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HL653_RS18705	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HL653_RS18710	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HL653_RS18725	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HL653_RS18730	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HL653_RS18780	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HL653_RS18805	ENOG4105C9K	Endothelin-converting enzyme 1
HL653_RS18815	ENOG4105CFH	Aspartokinase
HL653_RS18855	ENOG4105EA8	2-Nitropropane dioxygenase
HL653_RS18865	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HL653_RS18915	ENOG4105CVE	Lytic murein transglycosylase
HL653_RS18940	ENOG41082FS	50S ribosomal protein L31
HL653_RS18945	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HL653_RS18955	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL653_RS18960	ENOG4105DZP	Membrane-associated zinc metalloprotease
HL653_RS18980	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HL653_RS18990	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HL653_RS18995	ENOG4105CE9	30S ribosomal protein S2
HL653_RS19010	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HL653_RS19025	ENOG4105C5Q	Transcriptional regulator
HL653_RS19040	ENOG4108ZAF	Molybdopterin
HL653_RS19055	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HL653_RS19070	ENOG4105DWY	Agmatine deiminase
HL653_RS19085	ENOG4105E50	uracil-dna glycosylase
HL653_RS19090	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HL653_RS19110	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HL653_RS19115	ENOG4105FFC	UPF0187 protein
HL653_RS19125	ENOG4105FFC	UPF0187 protein
HL653_RS19135	ENOG4105CB5	ATP-dependent DNA helicase recG
HL653_RS19155	ENOG4108YIQ	Alpha beta hydrolase
HL653_RS19180	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL653_RS19185	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL653_RS19195	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL653_RS19200	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL653_RS19215	ENOG4106NZI	LysR family Transcriptional regulator
HL653_RS19225	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HL653_RS19230	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS19245	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HL653_RS19255	ENOG4105DTN	riboflavin biosynthesis protein ribF
HL653_RS19260	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HL653_RS19275	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HL653_RS19280	ENOG4105W5Q	DNA repair protein (RadC
HL653_RS19290	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HL653_RS19295	ENOG4105BZU	Histidine kinase
HL653_RS19300	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL653_RS19410	ENOG4107T0X	DNA ligase
HL653_RS19430	ENOG4105W0E	50S ribosomal protein L33
HL653_RS19440	ENOG4105EUB	pirin domain protein
HL653_RS19445	ENOG4105C2I	pirin domain protein
HL653_RS19455	ENOG4105C5Q	Transcriptional regulator
HL653_RS19465	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HL653_RS19470	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HL653_RS19480	ENOG4105SG9	biopolymer transport protein, ExbD
HL653_RS19485	ENOG4105E02	MotA TolQ exbB proton channel
HL653_RS19490	ENOG4107YD3	Thioesterase
HL653_RS19535	ENOG4107RDJ	Sulfotransferase
HL653_RS19540	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS19575	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HL653_RS19595	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HL653_RS19605	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HL653_RS19620	ENOG4105C3G	gtp-binding protein
HL653_RS19625	ENOG4105DXM	phenylacetic acid degradation protein
HL653_RS19635	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HL653_RS19650	ENOG4105DHU	Bile acid
HL653_RS19655	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HL653_RS19660	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HL653_RS19670	ENOG4108T5G	Adenylate
HL653_RS19690	ENOG4105CHH	sulfate transporter
HL653_RS19700	ENOG4105IIU	Aminopeptidase
HL653_RS19735	ENOG4105CA9	Pyruvate kinase
HL653_RS19750	ENOG4105C54	Major Facilitator superfamily
HL653_RS19770	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HL653_RS19780	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HL653_RS19785	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HL653_RS19795	ENOG4105BZU	Histidine kinase
HL653_RS19800	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HL653_RS19805	ENOG4105EB3	Histidine kinase
HL653_RS19810	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HL653_RS19815	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HL653_RS19820	ENOG4105DAS	pts system
HL653_RS19825	ENOG41080Z8	PHOSPHOCARRIER protein
HL653_RS19830	ENOG4105BZU	Histidine kinase
HL653_RS19835	ENOG4108RWN	rrna methyltransferase
HL653_RS19840	ENOG4105BZU	Histidine kinase
HL653_RS19845	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL653_RS19850	ENOG4105BZU	Histidine kinase
HL653_RS19855	ENOG4105BZU	Histidine kinase
HL653_RS19885	ENOG4108UQ8	endoribonuclease L-psp
HL653_RS19890	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HL653_RS19900	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HL653_RS19905	ENOG4105KVH	Transcriptional regulator
HL653_RS19920	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HL653_RS19925	ENOG4105C01	Dihydroxy-acid dehydratase
HL653_RS19940	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HL653_RS19950	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HL653_RS19960	ENOG4107SC1	transglycosylase
HL653_RS19965	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HL653_RS19980	ENOG4108UQY	Iron-storage protein
HL653_RS19995	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HL653_RS20000	ENOG4105ECK	Fatty Acid Desaturase
HL653_RS20050	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HL653_RS20055	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL653_RS20065	ENOG4107SFI	Major Facilitator superfamily
HL653_RS20075	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL653_RS20085	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HL653_RS20110	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS20115	ENOG4105BZS	acriflavin resistance protein
HL653_RS20120	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HL653_RS20125	ENOG4108YZT	Adenosylcobinamide kinase
HL653_RS20135	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
HL653_RS20140	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HL653_RS20150	ENOG4108374	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HL653_RS20160	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HL653_RS20205	ENOG4105EBR	Carboxylesterase
HL653_RS20215	ENOG4105CHR	reductase
HL653_RS20220	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
HL653_RS20225	ENOG4105D2H	Uronic isomerase
HL653_RS20230	ENOG4107KJX	Transcriptional regulator
HL653_RS20235	ENOG4105CTX	dehydratase
HL653_RS20240	ENOG4105DEI	Mannitol dehydrogenase
HL653_RS20250	ENOG4105DPW	Major facilitator superfamily MFS_1
HL653_RS20270	ENOG4108S0S	Nucleotidyl transferase
HL653_RS20275	ENOG4105EHM	Aminoglycoside phosphotransferase
HL653_RS20280	ENOG4105K8N	protein family UPF0079, ATPase
HL653_RS20285	ENOG4105I8F	Histidine kinase
HL653_RS20290	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HL653_RS20300	ENOG4108UJU	UPF0301 protein
HL653_RS20310	ENOG4105FYV	Amp nucleosidase
HL653_RS20315	ENOG4105BZU	Histidine kinase
HL653_RS20320	ENOG41082A2	Alpha beta hydrolase
HL653_RS20330	ENOG4105CHR	reductase
HL653_RS20340	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HL653_RS20345	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HL653_RS20355	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HL653_RS20365	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HL653_RS20370	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HL653_RS20375	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HL653_RS20380	ENOG4105D06	uba thif-type nad fad binding protein
HL653_RS20400	ENOG4108Z7R	Chaperone CsaA
HL653_RS20405	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HL653_RS20430	ENOG41089I4	Inherit from COG: Glycosyl transferase, family 2
HL653_RS20435	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HL653_RS20455	ENOG4105FAT	Acyl-transferase
HL653_RS20460	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HL653_RS20480	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HL653_RS20485	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HL653_RS20500	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HL653_RS20505	ENOG4105CXT	aspartate transcarbamylase
HL653_RS20510	ENOG4105CD3	dihydroorotase
HL653_RS20520	ENOG4105DC7	peptidase M24
HL653_RS20525	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HL653_RS20535	ENOG4105DJB	Major Facilitator Superfamily
HL653_RS20540	ENOG4105UVJ	5-dehydro-4-deoxyglucarate dehydratase
HL653_RS20550	ENOG4107RSM	transcriptional regulator
HL653_RS20555	ENOG4105EQX	glucarate dehydratase
HL653_RS20565	ENOG4105D64	Mechanosensitive ion channel
HL653_RS20570	ENOG4105DIA	mandelate racemase muconate lactonizing
HL653_RS20610	ENOG4108JSS	Haloalkane dehalogenase
HL653_RS20635	ENOG4105D05	Receptor
HL653_RS20685	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HL653_RS20715	ENOG4105D05	Receptor
HL653_RS20730	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HL653_RS20755	ENOG4105C26	Dehydrogenase
HL653_RS20760	ENOG4105CF7	AraC family transcriptional regulator
HL653_RS20765	ENOG4105EMU	Dehydrogenase
HL653_RS20780	ENOG4105CX8	fg-gap repeat protein
HL653_RS20785	ENOG4107TDE	lipolytic protein G-D-S-L family
HL653_RS20790	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS20800	ENOG4105EKC	
HL653_RS20825	ENOG4105M2Z	protein tyrosine serine phosphatase
HL653_RS20830	ENOG4108ESX	Receptor
HL653_RS20855	ENOG4107RNH	Outer membrane receptor FepA
HL653_RS20875	ENOG4105CNM	Receptor
HL653_RS20880	ENOG4108SF5	RNA Polymerase
HL653_RS20890	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS20895	ENOG4105E6M	Sulphatase-modifying factor protein
HL653_RS20980	ENOG4105WH1	Two component transcriptional regulator luxr family
HL653_RS20985	ENOG4108TN6	type iii secretion
HL653_RS21010	ENOG4105D00	flagellar biosynthetic protein flhB
HL653_RS21015	ENOG4105E4C	Lytic transglycosylase catalytic
HL653_RS21020	ENOG4108HR8	type iii secretion
HL653_RS21045	ENOG4107Y59	type iii secretion
HL653_RS21060	ENOG4108JIR	Flagellum-specific ATP synthase
HL653_RS21100	ENOG4105CHJ	isochorismatase hydrolase
HL653_RS21105	ENOG4105CC0	LysR family Transcriptional regulator
HL653_RS21115	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
HL653_RS21130	ENOG4105DJG	MaoC domain protein dehydratase
HL653_RS21140	ENOG4107QX3	carboxylase
HL653_RS21145	ENOG4105C1G	acyl-Coa dehydrogenase
HL653_RS21185	ENOG4105D05	Receptor
HL653_RS21205	ENOG4108R99	pseudouridine synthase
HL653_RS21210	ENOG4105D6S	protein involved in catabolism of external DNA
HL653_RS21215	ENOG4107ZSV	Receptor
HL653_RS21220	ENOG4105D2S	major facilitator superfamily
HL653_RS21225	ENOG4105C2C	drug resistance transporter, Bcr CflA
HL653_RS21230	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HL653_RS21235	ENOG4105C10	Electron transfer flavoprotein
HL653_RS21240	ENOG4105BZJ	Electron transfer flavoprotein
HL653_RS21270	ENOG4105D2S	major facilitator superfamily
HL653_RS21280	ENOG4105C26	Dehydrogenase
HL653_RS21300	ENOG41073TP	transcriptional regulator
HL653_RS21310	ENOG4105CD3	dihydroorotase
HL653_RS21315	ENOG4105JJR	Histidine kinase
HL653_RS21325	ENOG4108ESX	Receptor
HL653_RS21350	ENOG4105C7K	acetolactate synthase
HL653_RS21365	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
HL653_RS21380	ENOG4105HEI	LysR family (Transcriptional regulator
HL653_RS21405	ENOG4108XEP	Alpha Beta Hydrolase Fold protein
HL653_RS21440	ENOG4105CX8	fg-gap repeat protein
HL653_RS21475	ENOG4105EMN	RNA polymerase sigma factor
HL653_RS21525	ENOG4105E0F	Histidine kinase
HL653_RS21535	ENOG4105CNM	Receptor
HL653_RS21560	ENOG4105C4X	radical SAM domain protein
HL653_RS21585	ENOG4105C2J	ABC transporter
HL653_RS21605	ENOG4108C33	Resolvase
HL653_RS21620	ENOG4105CAK	Cell division ATP-binding protein ftsE
HL653_RS21650	ENOG4105CE1	Ferrous iron transport protein b
HL653_RS21655	ENOG4108UUM	single-stranded DNA-binding protein
HL653_RS21675	ENOG4105C6K	Malic enzyme
HL653_RS21690	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HL653_RS21695	ENOG4105K56	Transcriptional regulator
HL653_RS21700	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HL653_RS21770	ENOG4105DJ4	phosphatidylserine decarboxylase
HL653_RS21785	ENOG4107UX3	phosphatidylethanolamine N-methyltransferase
HL653_RS21790	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HL653_RS21795	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HL653_RS21800	ENOG4108Q9H	CobQ/CobB/MinD/ParA nucleotide binding domain
HL653_RS21830	ENOG4105DJB	Major Facilitator Superfamily
HL653_RS21835	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HL653_RS21840	ENOG4105DZG	Dehydrogenase
HL653_RS21860	ENOG4105D05	Receptor
HL653_RS21870	ENOG4107S9B	Shikimate dehydrogenase
HL653_RS21875	ENOG4108NEV	two component transcriptional regulator, LytTR family
HL653_RS21880	ENOG4105C2F	Histidine kinase
HL653_RS21890	ENOG4105DGI	Alkaline phosphatase
HL653_RS21905	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HL653_RS21920	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HL653_RS21990	ENOG4105E6M	Sulphatase-modifying factor protein
HL653_RS22020	ENOG4105EMN	RNA polymerase sigma factor
HL653_RS22045	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL653_RS22070	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HL653_RS22090	ENOG4108F3G	Type I restriction-modification system, R subunit
HL653_RS22120	ENOG4108YXV	Transcriptional regulator
HL653_RS22155	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HL653_RS22165	ENOG4108S3W	Anti-feci sigma factor, fecr
HL653_RS22170	ENOG4108KPJ	rna polymerase sigma factor
HL653_RS22190	ENOG41064T2	transcriptional regulator, lysR family
HL653_RS22200	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HL653_RS22205	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS22215	ENOG4107XII	Glycosyl Hydrolase Family 88
HL653_RS22240	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HL653_RS22245	ENOG4105BZU	Histidine kinase
HL653_RS22260	ENOG4105C26	Dehydrogenase
HL653_RS22275	ENOG4105BZU	Histidine kinase
HL653_RS22295	ENOG4105DZG	Dehydrogenase
HL653_RS22310	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HL653_RS22315	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HL653_RS22340	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HL653_RS22360	ENOG4105DZG	Dehydrogenase
HL653_RS22370	ENOG4105D05	Receptor
HL653_RS22375	ENOG4107HP6	Transcriptional regulator
HL653_RS22380	ENOG4108I5G	Major Facilitator superfamily
HL653_RS22395	ENOG4105CXK	mandelate racemase muconate lactonizing
HL653_RS22400	ENOG4105CSP	Major Facilitator Superfamily
HL653_RS22405	ENOG4107QNK	)-transporter
HL653_RS22410	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HL653_RS22415	ENOG4105CXK	mandelate racemase muconate lactonizing
HL653_RS22420	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HL653_RS22430	ENOG4105DIN	metallophosphoesterase
HL653_RS22435	ENOG4105VEQ	Cold shock protein
HL653_RS22440	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HL653_RS22455	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HL653_RS22460	ENOG4105CCU	oxidase (Subunit III)
HL653_RS22465	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HL653_RS22470	ENOG4105E2S	oxidase) subunit II
HL653_RS22485	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HL653_RS22490	ENOG4108Z0Z	intracellular protease Pfpi family
HL653_RS22500	ENOG4105WH1	Two component transcriptional regulator luxr family
HL653_RS22510	ENOG4108J2P	Alpha beta hydrolase fold
HL653_RS22585	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
HL653_RS22660	ENOG4108YXV	Transcriptional regulator
HL653_RS22760	ENOG4105CQZ	Histidine kinase
HL653_RS22775	ENOG4107XGZ	Hydrolase
HL653_RS22790	ENOG4108UJV	acyl-CoA thioesterase i
HL653_RS22795	ENOG41074H6	response regulator
HL653_RS22800	ENOG4105CQZ	Histidine kinase
HL653_RS22810	ENOG4105BZU	Histidine kinase
HL653_RS22840	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HL653_RS22875	ENOG4105BZ1	(ABC) transporter
HL653_RS22960	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HL653_RS22965	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HL653_RS22975	ENOG4105P0T	Usg family
HL653_RS22980	ENOG4105VN1	Heat shock protein
HL653_RS22985	ENOG4108ZNX	Heat shock protein
HL653_RS22990	ENOG4105KT7	mgtC SapB transporter
HL653_RS23015	ENOG4105EQR	Transposase IS116 IS110 IS902
HL653_RS23020	ENOG4105EQR	Transposase IS116 IS110 IS902
HL653_RS23025	ENOG4107QHQ	amino acid
HL653_RS23040	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HL653_RS23060	ENOG41074H6	response regulator
HL653_RS23090	ENOG4105CHR	reductase
HL653_RS23095	ENOG4105KVH	Transcriptional regulator
HL653_RS23100	ENOG4105CBN	LysR family transcriptional regulator
HL653_RS23110	ENOG4105E1F	short-chain dehydrogenase reductase
HL653_RS23120	ENOG4108M8H	domain protein
HL653_RS23165	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HL653_RS23170	ENOG4105HMI	Membrane
HL653_RS23175	ENOG4105DUM	transcriptional regulator, lysR family
HL653_RS23245	ENOG4108HKT	sucrose-6-phosphate hydrolase
HL653_RS23255	ENOG4105DRS	transport system, permease
HL653_RS23260	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL653_RS23280	ENOG4105ETE	Transcriptional regulator (LacI family
HL653_RS23325	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HL653_RS23340	ENOG4105EMN	RNA polymerase sigma factor
HL653_RS23395	ENOG4105FDF	Could be involved in DNA repair (By similarity)
HL653_RS23415	ENOG4105DQE	DNA ligase
HL653_RS23420	ENOG4105CGK	Exodeoxyribonuclease III
HL653_RS23475	ENOG4107FW0	short-chain dehydrogenase reductase
HL653_RS23495	ENOG4107JEE	Short-chain dehydrogenase reductase Sdr
HL653_RS23515	ENOG4105GN4	DNA ligase
HL653_RS23525	ENOG4105GTG	Isochorismatase
HL653_RS23530	ENOG4105CHR	reductase
HL653_RS23540	ENOG4105BZU	Histidine kinase
HL653_RS23545	ENOG41074H6	response regulator
HL653_RS23580	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HL653_RS23585	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL653_RS23590	ENOG4107XKX	isoquinoline 1-oxidoreductase, alpha subunit
HL653_RS23595	ENOG4105DIP	Molybdopterin dehydrogenase FAD-binding
HL653_RS23600	ENOG4105C7W	Xanthine dehydrogenase
HL653_RS23635	ENOG4105DFP	Integrase
HL653_RS23665	ENOG4105CBX	hi0933 family
HL653_RS23695	ENOG4108KPJ	rna polymerase sigma factor
HL653_RS23720	ENOG4105E2K	Glycosyl transferase (Group 1
HL653_RS23745	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HL653_RS23750	ENOG4105BZS	acriflavin resistance protein
HL653_RS23755	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HL653_RS23770	ENOG4105EAC	phosphoserine phosphatase
HL653_RS23775	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HL653_RS23785	ENOG4105C7K	acetolactate synthase
HL653_RS23790	ENOG4108C33	Resolvase
HL653_RS23825	ENOG4105K89	arsenate reductase
HL653_RS23845	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase