locus-tag	class	description
HL653_RS00005	COG0440	acetolactate synthase activity
HL653_RS00010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HL653_RS00050	COG0556	nucleotide-excision repair
HL653_RS00070	COG1136	(ABC) transporter
HL653_RS00080	COG0442	prolyl-tRNA aminoacylation
HL653_RS00090	COG0640	Transcriptional regulator
HL653_RS00095	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS00105	COG0504	CTP synthase activity
HL653_RS00120	COG0149	triose-phosphate isomerase activity
HL653_RS00125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL653_RS00130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HL653_RS00155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL653_RS00165	COG0134	indole-3-glycerol-phosphate synthase activity
HL653_RS00170	COG0315	cyclic pyranopterin monophosphate synthase activity
HL653_RS00175	COG0303	'Molybdopterin
HL653_RS00180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HL653_RS00195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL653_RS00210	COG0531	amino acid
HL653_RS00225	COG0477	Major facilitator Superfamily
HL653_RS00230	COG0443	Heat shock 70 kDa protein
HL653_RS00235	COG0673	inositol 2-dehydrogenase activity
HL653_RS00245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL653_RS00255	COG0587	DNA-directed DNA polymerase activity
HL653_RS00260	COG5001	Diguanylate cyclase
HL653_RS00260	COG3300	MHYT domain
HL653_RS00300	COG1002	Type II restriction enzyme, methylase subunits
HL653_RS00310	COG1061	Type III restriction enzyme res subunit
HL653_RS00315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL653_RS00350	COG0655	NAD(P)H dehydrogenase (quinone) activity
HL653_RS00355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL653_RS00415	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HL653_RS00420	COG0412	Dienelactone hydrolase
HL653_RS00425	COG4946	Tricorn protease homolog
HL653_RS00425	COG0793	Belongs to the peptidase S41A family
HL653_RS00435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL653_RS00445	COG1862	Preprotein translocase
HL653_RS00465	COG2201	protein-glutamate methylesterase activity
HL653_RS00490	COG1213	nucleotidyl transferase
HL653_RS00510	COG3664	PFAM glycoside hydrolase family 39
HL653_RS00565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HL653_RS00570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HL653_RS00585	COG0586	Pfam SNARE associated Golgi protein
HL653_RS00600	COG0513	Belongs to the DEAD box helicase family
HL653_RS00610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HL653_RS00640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HL653_RS00645	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HL653_RS00665	COG2301	Belongs to the HpcH HpaI aldolase family
HL653_RS00685	COG0138	bifunctional purine biosynthesis protein purh
HL653_RS00690	COG3128	pkhd-type hydroxylase
HL653_RS00700	COG4774	siderophore transport
HL653_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS00715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HL653_RS00725	COG1045	serine acetyltransferase
HL653_RS00730	COG1115	amino acid carrier protein
HL653_RS00750	COG0438	transferase activity, transferring glycosyl groups
HL653_RS00765	COG0438	transferase activity, transferring glycosyl groups
HL653_RS00780	COG4771	TonB-dependent receptor
HL653_RS00805	COG2814	Major facilitator Superfamily
HL653_RS00810	COG1070	Carbohydrate kinase
HL653_RS00845	COG1902	pentaerythritol trinitrate reductase activity
HL653_RS00855	COG1131	(ABC) transporter
HL653_RS00860	COG0842	Transport permease protein
HL653_RS00865	COG0497	DNA recombination
HL653_RS00870	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL653_RS00895	COG2852	Protein conserved in bacteria
HL653_RS00910	COG0758	DNA mediated transformation
HL653_RS00915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HL653_RS00920	COG3237	CsbD-like
HL653_RS00935	COG0436	Aminotransferase
HL653_RS00940	COG3243	poly(R)-hydroxyalkanoic acid synthase
HL653_RS00980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HL653_RS00985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HL653_RS01005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL653_RS01010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL653_RS01020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HL653_RS01025	COG0602	queuosine metabolic process
HL653_RS01040	COG0321	lipoyl(octanoyl) transferase activity
HL653_RS01055	COG0408	coproporphyrinogen oxidase activity
HL653_RS01060	COG0723	plastoquinol--plastocyanin reductase activity
HL653_RS01095	COG4181	ATPase activity
HL653_RS01105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL653_RS01130	COG3250	beta-galactosidase activity
HL653_RS01135	COG2186	Transcriptional regulator
HL653_RS01140	COG2271	Major facilitator Superfamily
HL653_RS01150	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HL653_RS01160	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HL653_RS01175	COG4771	TonB-dependent receptor
HL653_RS01200	COG0525	valine-tRNA ligase activity
HL653_RS01220	COG0484	heat shock protein binding
HL653_RS01225	COG0443	Heat shock 70 kDa protein
HL653_RS01240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL653_RS01245	COG1420	regulation of RNA biosynthetic process
HL653_RS01260	COG2945	thiolester hydrolase activity
HL653_RS01265	COG1104	cysteine desulfurase activity
HL653_RS01270	COG1104	cysteine desulfurase activity
HL653_RS01280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HL653_RS01285	COG2968	Membrane
HL653_RS01295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL653_RS01310	COG1051	belongs to the nudix hydrolase family
HL653_RS01320	COG0415	Belongs to the DNA photolyase family
HL653_RS01325	COG4221	oxidoreductase activity
HL653_RS01330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HL653_RS01335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HL653_RS01350	COG0006	proline dipeptidase activity
HL653_RS01370	COG4221	oxidoreductase activity
HL653_RS01390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HL653_RS01410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HL653_RS01430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL653_RS01450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HL653_RS01455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL653_RS01460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL653_RS01475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL653_RS01485	COG0360	Binds together with S18 to 16S ribosomal RNA
HL653_RS01490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HL653_RS01495	COG0359	binds to the 23S rRNA
HL653_RS01500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL653_RS01510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HL653_RS01515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HL653_RS01520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL653_RS01525	COG3107	peptidoglycan biosynthetic process
HL653_RS01530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HL653_RS01535	COG0792	nuclease activity
HL653_RS01540	COG0189	ligase activity
HL653_RS01550	COG1174	glycine betaine transport
HL653_RS01555	COG0517	IMP dehydrogenase activity
HL653_RS01555	COG1125	glycine betaine transport
HL653_RS01560	COG2154	pterin-4-alpha-carbinolamine dehydratase
HL653_RS01570	COG4133	protoheme IX ABC transporter activity
HL653_RS01575	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL653_RS01590	COG0612	Peptidase, M16
HL653_RS01615	COG0109	protoheme IX farnesyltransferase activity
HL653_RS01630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HL653_RS01635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HL653_RS01640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HL653_RS01645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HL653_RS01650	COG0736	holo-[acyl-carrier-protein] synthase activity
HL653_RS01655	COG0681	Belongs to the peptidase S26 family
HL653_RS01665	COG0545	Peptidyl-prolyl cis-trans isomerase
HL653_RS01670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HL653_RS01700	COG0433	COG0433 Predicted ATPase
HL653_RS01720	COG0330	HflC and HflK could
HL653_RS01725	COG0489	protein tyrosine kinase activity
HL653_RS01730	COG1832	CoA-binding protein
HL653_RS01740	COG0312	modulator of DNA gyrase
HL653_RS01745	COG1733	regulation of RNA biosynthetic process
HL653_RS01750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HL653_RS01815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL653_RS01850	COG1566	PFAM secretion protein HlyD family protein
HL653_RS01855	COG2814	Major facilitator Superfamily
HL653_RS01870	COG1872	DUF167
HL653_RS01885	COG0316	Belongs to the HesB IscA family
HL653_RS01890	COG0739	heme binding
HL653_RS01895	COG2833	Protein of unknown function (DUF455)
HL653_RS01900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HL653_RS01905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HL653_RS01925	COG0784	Response regulator, receiver
HL653_RS01945	COG0805	protein transport
HL653_RS01950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL653_RS01955	COG1253	flavin adenine dinucleotide binding
HL653_RS01970	COG2860	membrane
HL653_RS01975	COG1201	RNA secondary structure unwinding
HL653_RS01990	COG3179	chitinase
HL653_RS02010	COG1192	Involved in chromosome partitioning
HL653_RS02050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HL653_RS02065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL653_RS02065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL653_RS02075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL653_RS02105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL653_RS02130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HL653_RS02135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HL653_RS02145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HL653_RS02150	COG0072	phenylalanine-tRNA ligase activity
HL653_RS02155	COG2813	Specifically methylates the guanine in position
HL653_RS02155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL653_RS02165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL653_RS02170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL653_RS02175	COG0287	Prephenate dehydrogenase
HL653_RS02205	COG1494	fructose-1,6-bisphosphatase
HL653_RS02210	COG2084	Dehydrogenase
HL653_RS02220	COG0335	large ribosomal subunit rRNA binding
HL653_RS02225	COG0336	Belongs to the RNA methyltransferase TrmD family
HL653_RS02250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HL653_RS02255	COG0228	four-way junction DNA binding
HL653_RS02260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HL653_RS02275	COG2308	Evidence 4 Homologs of previously reported genes of
HL653_RS02285	COG0745	RESPONSE REGULATOR receiver
HL653_RS02290	COG0564	pseudouridine synthase activity
HL653_RS02300	COG1956	GAF domain-containing protein
HL653_RS02320	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HL653_RS02330	COG1758	RNA polymerase activity
HL653_RS02345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL653_RS02350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL653_RS02355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HL653_RS02365	COG1051	belongs to the nudix hydrolase family
HL653_RS02400	COG5507	3-demethylubiquinone-9 3-methyltransferase
HL653_RS02435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL653_RS02450	COG1231	oxidoreductase activity
HL653_RS02465	COG3813	Protein conserved in bacteria
HL653_RS02480	COG2252	PERMEase
HL653_RS02495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HL653_RS02515	COG2072	flavoprotein involved in K transport
HL653_RS02520	COG2351	hydroxyisourate hydrolase activity
HL653_RS02535	COG0402	S-adenosylhomocysteine deaminase activity
HL653_RS02540	COG0784	Response regulator, receiver
HL653_RS02540	COG4191	Histidine kinase
HL653_RS02545	COG0156	8-amino-7-oxononanoate synthase activity
HL653_RS02565	COG0113	porphobilinogen synthase activity
HL653_RS02665	COG1522	sequence-specific DNA binding
HL653_RS02690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL653_RS02695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL653_RS02725	COG1677	Flagellar hook-basal body complex protein FliE
HL653_RS02735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL653_RS02745	COG3706	GGDEF domain
HL653_RS02790	COG1987	bacterial-type flagellum assembly
HL653_RS02805	COG2890	protein-(glutamine-N5) methyltransferase activity
HL653_RS02815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HL653_RS02820	COG0124	histidyl-tRNA synthetase
HL653_RS02825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HL653_RS02840	COG1360	Flagellar Motor Protein
HL653_RS02850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HL653_RS02855	COG1256	bacterial-type flagellum assembly
HL653_RS02855	COG4786	Flagellar basal body rod
HL653_RS02865	COG1706	bacterial-type flagellum-dependent cell motility
HL653_RS02870	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HL653_RS02885	COG1749	Flagellar hook protein flgE
HL653_RS02890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HL653_RS02895	COG1558	bacterial-type flagellum-dependent cell motility
HL653_RS02905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HL653_RS02930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL653_RS02950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HL653_RS02955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HL653_RS02960	COG2096	Adenosyltransferase
HL653_RS02970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL653_RS02980	COG1595	DNA-templated transcription, initiation
HL653_RS02985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL653_RS02990	COG0308	aminopeptidase N
HL653_RS03015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL653_RS03025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HL653_RS03035	COG2095	MarC family integral membrane protein
HL653_RS03065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL653_RS03065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL653_RS03080	COG2166	iron-sulfur cluster assembly
HL653_RS03085	COG1335	isochorismatase
HL653_RS03090	COG0251	oxidation-reduction process
HL653_RS03095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HL653_RS03100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL653_RS03120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL653_RS03125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HL653_RS03150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HL653_RS03155	COG0346	lactoylglutathione lyase activity
HL653_RS03160	COG2824	Alkylphosphonate utilization operon protein PhnA
HL653_RS03175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL653_RS03175	COG1199	ATP-dependent helicase activity
HL653_RS03225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL653_RS03260	COG0840	transmembrane signaling receptor activity
HL653_RS03280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL653_RS03285	COG1392	Phosphate transport regulator
HL653_RS03290	COG0306	phosphate transporter
HL653_RS03335	COG3104	oligopeptide transport
HL653_RS03350	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS03355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HL653_RS03360	COG1522	sequence-specific DNA binding
HL653_RS03370	COG4771	TonB-dependent receptor
HL653_RS03375	COG1522	sequence-specific DNA binding
HL653_RS03475	COG3668	Plasmid stabilization system
HL653_RS03480	COG3077	Addiction module antitoxin, RelB DinJ family
HL653_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS03510	COG0667	Aldo Keto reductase
HL653_RS03515	COG1335	isochorismatase
HL653_RS03520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL653_RS03525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL653_RS03530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL653_RS03535	COG2080	2 iron, 2 sulfur cluster binding
HL653_RS03620	COG4974	Belongs to the 'phage' integrase family
HL653_RS03655	COG0582	viral genome integration into host DNA
HL653_RS03670	COG1968	undecaprenyl-diphosphatase activity
HL653_RS03695	COG2329	Antibiotic biosynthesis monooxygenase
HL653_RS03700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL653_RS03705	COG0583	DNA-binding transcription factor activity
HL653_RS03715	COG2239	Acts as a magnesium transporter
HL653_RS03745	COG1329	Transcriptional regulator
HL653_RS03765	COG0739	heme binding
HL653_RS03770	COG5265	(ABC) transporter
HL653_RS03785	COG0514	ATP-dependent DNA helicase (RecQ)
HL653_RS03790	COG1295	ribonuclease BN
HL653_RS03800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HL653_RS03810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HL653_RS03815	COG1505	serine-type exopeptidase activity
HL653_RS03820	COG0203	ribosomal protein L17
HL653_RS03825	COG0202	RNA polymerase activity
HL653_RS03830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL653_RS03835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL653_RS03840	COG0563	adenylate kinase activity
HL653_RS03845	COG0201	protein transport
HL653_RS03850	COG0200	Binds to the 23S rRNA
HL653_RS03855	COG2755	lipolytic protein G-D-S-L family
HL653_RS03855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HL653_RS03860	COG1841	ribosomal large subunit assembly
HL653_RS03865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HL653_RS03870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HL653_RS03875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HL653_RS03880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HL653_RS03885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HL653_RS03890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL653_RS03895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HL653_RS03900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HL653_RS03905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HL653_RS03910	COG0255	Belongs to the universal ribosomal protein uL29 family
HL653_RS03915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HL653_RS03920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HL653_RS03925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HL653_RS03930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HL653_RS03935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL653_RS03940	COG0089	rRNA binding
HL653_RS03945	COG0088	Forms part of the polypeptide exit tunnel
HL653_RS03950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HL653_RS03955	COG0051	transcription antitermination factor activity, RNA binding
HL653_RS03960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL653_RS03965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL653_RS03970	COG0049	tRNA binding
HL653_RS03975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HL653_RS04015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL653_RS04025	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL653_RS04050	COG0316	Belongs to the HesB IscA family
HL653_RS04055	COG2151	metal-sulfur cluster biosynthetic enzyme
HL653_RS04060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL653_RS04065	COG0719	Fe-S assembly protein
HL653_RS04070	COG0396	ATPase activity
HL653_RS04080	COG2852	Protein conserved in bacteria
HL653_RS04085	COG0719	Fe-S assembly protein
HL653_RS04095	COG2832	Protein of unknown function (DUF454)
HL653_RS04100	COG0167	dihydroorotate dehydrogenase activity
HL653_RS04110	COG0405	Gamma-glutamyltransferase
HL653_RS04115	COG1022	Amp-dependent synthetase and ligase
HL653_RS04125	COG2070	2-Nitropropane dioxygenase
HL653_RS04135	COG2917	probably involved in intracellular septation
HL653_RS04140	COG0552	protein localization to endoplasmic reticulum
HL653_RS04145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL653_RS04150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL653_RS04155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HL653_RS04170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HL653_RS04175	COG1295	ribonuclease BN
HL653_RS04180	COG0484	heat shock protein binding
HL653_RS04190	COG0584	glycerophosphoryl diester phosphodiesterase
HL653_RS04200	COG2307	Protein conserved in bacteria
HL653_RS04200	COG2308	Evidence 4 Homologs of previously reported genes of
HL653_RS04250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HL653_RS04360	COG5489	Protein of unknown function (DUF736)
HL653_RS04390	COG1192	Involved in chromosome partitioning
HL653_RS04415	COG0739	heme binding
HL653_RS04415	COG0741	lytic transglycosylase activity
HL653_RS04415	COG1196	nuclear chromosome segregation
HL653_RS04455	COG4962	Type ii secretion system protein e
HL653_RS04470	COG3451	type IV secretory pathway VirB4
HL653_RS04485	COG3846	protein secretion by the type IV secretion system
HL653_RS04520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL653_RS04560	COG0702	epimerase
HL653_RS04565	COG1733	regulation of RNA biosynthetic process
HL653_RS04570	COG3268	Saccharopine dehydrogenase
HL653_RS04590	COG0582	viral genome integration into host DNA
HL653_RS04595	COG0519	Catalyzes the synthesis of GMP from XMP
HL653_RS04595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HL653_RS04605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL653_RS04615	COG1648	precorrin-2 dehydrogenase activity
HL653_RS04615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HL653_RS04630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HL653_RS04635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL653_RS04645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HL653_RS04650	COG1137	ATPase activity
HL653_RS04660	COG0438	transferase activity, transferring glycosyl groups
HL653_RS04665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HL653_RS04685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HL653_RS04690	COG1215	transferase activity, transferring glycosyl groups
HL653_RS04700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL653_RS04710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HL653_RS04715	COG1254	Belongs to the acylphosphatase family
HL653_RS04730	COG2086	electron transfer activity
HL653_RS04735	COG0045	succinate-CoA ligase (ADP-forming) activity
HL653_RS04755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL653_RS04795	COG2852	Protein conserved in bacteria
HL653_RS04805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HL653_RS04810	COG0165	Argininosuccinate lyase
HL653_RS04820	COG0019	diaminopimelate decarboxylase activity
HL653_RS04825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HL653_RS04830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HL653_RS04870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL653_RS04875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HL653_RS04885	COG2983	Belongs to the UPF0260 family
HL653_RS04890	COG1999	signal sequence binding
HL653_RS04910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL653_RS04915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HL653_RS04925	COG0237	dephospho-CoA kinase activity
HL653_RS04930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL653_RS04935	COG0424	maF-like protein
HL653_RS04940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HL653_RS04945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HL653_RS04955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HL653_RS04960	COG0861	Integral membrane protein TerC family
HL653_RS04980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL653_RS04985	COG0445	tRNA wobble uridine modification
HL653_RS04990	COG0357	Ribosomal RNA small subunit methyltransferase G
HL653_RS05015	COG0495	leucyl-tRNA aminoacylation
HL653_RS05035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL653_RS05050	COG0708	Exodeoxyribonuclease III
HL653_RS05065	COG1674	ftsk spoiiie
HL653_RS05080	COG1127	ABC transporter
HL653_RS05095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL653_RS05100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HL653_RS05115	COG0137	argininosuccinate synthase activity
HL653_RS05125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL653_RS05130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HL653_RS05135	COG0438	transferase activity, transferring glycosyl groups
HL653_RS05160	COG1596	polysaccharide export
HL653_RS05170	COG3206	protein involved in exopolysaccharide biosynthesis
HL653_RS05170	COG0489	protein tyrosine kinase activity
HL653_RS05185	COG0656	L-ascorbic acid biosynthetic process
HL653_RS05190	COG0673	inositol 2-dehydrogenase activity
HL653_RS05230	COG0438	transferase activity, transferring glycosyl groups
HL653_RS05260	COG2267	carboxylic ester hydrolase activity
HL653_RS05290	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HL653_RS05300	COG1842	Phage shock protein A
HL653_RS05330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HL653_RS05345	COG0135	phosphoribosylanthranilate isomerase activity
HL653_RS05350	COG0133	tryptophan synthase activity
HL653_RS05355	COG0159	tryptophan synthase activity
HL653_RS05360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HL653_RS05365	COG0285	dihydrofolate synthase activity
HL653_RS05380	COG2852	Protein conserved in bacteria
HL653_RS05390	COG0776	regulation of translation
HL653_RS05395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL653_RS05400	COG0416	fatty acid biosynthetic process
HL653_RS05405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HL653_RS05415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL653_RS05430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL653_RS05440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL653_RS05445	COG0424	maF-like protein
HL653_RS05455	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HL653_RS05475	COG3577	Aspartyl protease
HL653_RS05480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HL653_RS05490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HL653_RS05510	COG1473	amidohydrolase
HL653_RS05525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL653_RS05530	COG0517	IMP dehydrogenase activity
HL653_RS05530	COG0516	GMP reductase activity
HL653_RS05565	COG0582	viral genome integration into host DNA
HL653_RS05595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL653_RS05595	COG2169	Transcriptional regulator
HL653_RS05600	COG2169	Transcriptional regulator
HL653_RS05600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL653_RS05620	COG0583	DNA-binding transcription factor activity
HL653_RS05640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HL653_RS05670	COG0454	-acetyltransferase
HL653_RS05690	COG2205	protein histidine kinase activity
HL653_RS05715	COG0583	DNA-binding transcription factor activity
HL653_RS05735	COG0667	Aldo Keto reductase
HL653_RS05740	COG0601	transmembrane transport
HL653_RS05745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL653_RS05750	COG0444	Belongs to the ABC transporter superfamily
HL653_RS05755	COG4608	Belongs to the ABC transporter superfamily
HL653_RS05765	COG2814	Major facilitator Superfamily
HL653_RS05770	COG0667	Aldo Keto reductase
HL653_RS05775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL653_RS05780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL653_RS05820	COG1937	Protein conserved in bacteria
HL653_RS05830	COG0667	Aldo Keto reductase
HL653_RS05835	COG2814	Major facilitator Superfamily
HL653_RS05855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL653_RS05925	COG4957	zinc ion binding
HL653_RS05940	COG4957	zinc ion binding
HL653_RS05970	COG3300	MHYT domain
HL653_RS05970	COG5001	Diguanylate cyclase
HL653_RS06030	COG1338	Plays a role in the flagellum-specific transport system
HL653_RS06035	COG3190	flagellar
HL653_RS06045	COG1558	bacterial-type flagellum-dependent cell motility
HL653_RS06050	COG1677	Flagellar hook-basal body complex protein FliE
HL653_RS06055	COG1987	bacterial-type flagellum assembly
HL653_RS06060	COG1684	flagellar biosynthetic protein fliR
HL653_RS06065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL653_RS06070	COG1706	bacterial-type flagellum-dependent cell motility
HL653_RS06075	COG1705	Flagellar rod assembly protein muramidase FlgJ
HL653_RS06075	COG3951	Flagellar rod assembly protein muramidase FlgJ
HL653_RS06110	COG5443	negative regulation of bacterial-type flagellum assembly
HL653_RS06135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HL653_RS06145	COG4566	intracellular signal transduction
HL653_RS06150	COG1815	bacterial-type flagellum-dependent cell motility
HL653_RS06155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL653_RS06160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL653_RS06170	COG1766	The M ring may be actively involved in energy transduction
HL653_RS06175	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL653_RS06180	COG2204	response regulator
HL653_RS06185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL653_RS06195	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HL653_RS06205	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HL653_RS06215	COG4786	Flagellar basal body rod
HL653_RS06220	COG4786	Flagellar basal body rod
HL653_RS06260	COG0840	transmembrane signaling receptor activity
HL653_RS06265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HL653_RS06270	COG2201	protein-glutamate methylesterase activity
HL653_RS06280	COG0835	chemotaxis
HL653_RS06290	COG5442	Flagellar protein FlaF
HL653_RS06295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HL653_RS06305	COG0745	RESPONSE REGULATOR receiver
HL653_RS06310	COG2198	Histidine kinase
HL653_RS06310	COG0643	Histidine kinase
HL653_RS06315	COG0745	RESPONSE REGULATOR receiver
HL653_RS06335	COG0590	tRNA wobble adenosine to inosine editing
HL653_RS06340	COG2198	Histidine kinase
HL653_RS06340	COG0784	Response regulator, receiver
HL653_RS06340	COG2205	protein histidine kinase activity
HL653_RS06345	COG0784	Response regulator, receiver
HL653_RS06345	COG2205	protein histidine kinase activity
HL653_RS06360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HL653_RS06365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HL653_RS06370	COG0799	negative regulation of ribosome biogenesis
HL653_RS06375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HL653_RS06385	COG0793	Belongs to the peptidase S41A family
HL653_RS06395	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HL653_RS06410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HL653_RS06415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HL653_RS06420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL653_RS06425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL653_RS06430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HL653_RS06440	COG1393	Belongs to the ArsC family
HL653_RS06450	COG1597	lipid kinase activity
HL653_RS06460	COG5001	Diguanylate cyclase
HL653_RS06460	COG3447	MASE1 domain protein
HL653_RS06460	COG5002	protein histidine kinase activity
HL653_RS06465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HL653_RS06470	COG0459	protein refolding
HL653_RS06475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL653_RS06480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HL653_RS06485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL653_RS06490	COG0101	tRNA pseudouridine synthase activity
HL653_RS06510	COG0492	ferredoxin-NADP+ reductase activity
HL653_RS06535	COG0242	peptide deformylase activity
HL653_RS06545	COG1322	Protein conserved in bacteria
HL653_RS06560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL653_RS06565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL653_RS06580	COG0671	phosphoesterase, PA-phosphatase related
HL653_RS06590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL653_RS06595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HL653_RS06610	COG3394	polysaccharide catabolic process
HL653_RS06615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL653_RS06625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL653_RS06635	COG1562	ergosterol biosynthetic process
HL653_RS06640	COG1562	ergosterol biosynthetic process
HL653_RS06645	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HL653_RS06650	COG1657	PFAM Prenyltransferase squalene oxidase
HL653_RS06660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL653_RS06665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL653_RS06675	COG2853	Lipoprotein
HL653_RS06705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HL653_RS06715	COG0346	lactoylglutathione lyase activity
HL653_RS06720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL653_RS06720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HL653_RS06725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL653_RS06730	COG4770	biotin carboxylase activity
HL653_RS06745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HL653_RS06750	COG2897	thiosulfate sulfurtransferase activity
HL653_RS06755	COG0626	cystathionine gamma-synthase activity
HL653_RS06790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HL653_RS06790	COG2885	chlorophyll binding
HL653_RS06795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HL653_RS06800	COG0670	Belongs to the BI1 family
HL653_RS06805	COG2255	four-way junction helicase activity
HL653_RS06815	COG0632	four-way junction helicase activity
HL653_RS06820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HL653_RS06825	COG0217	transcriptional regulatory protein
HL653_RS06835	COG3750	Belongs to the UPF0335 family
HL653_RS06840	COG1760	l-serine dehydratase
HL653_RS06845	COG0686	Belongs to the AlaDH PNT family
HL653_RS06850	COG1522	sequence-specific DNA binding
HL653_RS06855	COG3158	transport of potassium into the cell
HL653_RS06875	COG0488	(ABC) transporter
HL653_RS06890	COG3940	Belongs to the glycosyl hydrolase 43 family
HL653_RS06895	COG0343	queuine tRNA-ribosyltransferase activity
HL653_RS06910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HL653_RS06920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HL653_RS06930	COG1722	exodeoxyribonuclease VII activity
HL653_RS06945	COG0534	Mate efflux family protein
HL653_RS06965	COG4251	negative regulation of phosphorylation
HL653_RS06970	COG1940	carbohydrate kinase activity
HL653_RS07005	COG0513	Belongs to the DEAD box helicase family
HL653_RS07010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL653_RS07015	COG1764	response to oxidative stress
HL653_RS07045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL653_RS07070	COG2197	response regulator
HL653_RS07085	COG4771	TonB-dependent receptor
HL653_RS07085	COG1629	transport
HL653_RS07095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HL653_RS07100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HL653_RS07105	COG1612	heme a metabolic process
HL653_RS07115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HL653_RS07135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HL653_RS07170	COG1482	cell wall glycoprotein biosynthetic process
HL653_RS07180	COG0300	oxidoreductase activity
HL653_RS07195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HL653_RS07200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HL653_RS07205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL653_RS07205	COG0517	IMP dehydrogenase activity
HL653_RS07210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HL653_RS07220	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HL653_RS07320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL653_RS07345	COG0156	8-amino-7-oxononanoate synthase activity
HL653_RS07360	COG5285	phytanoyl-CoA dioxygenase
HL653_RS07370	COG1088	dTDP-glucose 4,6-dehydratase activity
HL653_RS07375	COG1091	dTDP-4-dehydrorhamnose reductase activity
HL653_RS07380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HL653_RS07400	COG2205	protein histidine kinase activity
HL653_RS07420	COG4689	acetoacetate decarboxylase
HL653_RS07425	COG4689	acetoacetate decarboxylase
HL653_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS07445	COG0477	Major facilitator Superfamily
HL653_RS07465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL653_RS07485	COG0779	Required for maturation of 30S ribosomal subunits
HL653_RS07490	COG2133	pyrroloquinoline quinone binding
HL653_RS07500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HL653_RS07510	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL653_RS07520	COG1530	ribonuclease E activity
HL653_RS07610	COG4795	General secretion pathway protein
HL653_RS07640	COG0475	glutathione-regulated potassium exporter activity
HL653_RS07640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HL653_RS07660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL653_RS07680	COG4974	Belongs to the 'phage' integrase family
HL653_RS07685	COG0825	malonyl-CoA metabolic process
HL653_RS07700	COG0494	nUDIX hydrolase
HL653_RS07710	COG1040	competence protein
HL653_RS07715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HL653_RS07720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL653_RS07750	COG0477	Major facilitator Superfamily
HL653_RS07790	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HL653_RS07795	COG2205	protein histidine kinase activity
HL653_RS07800	COG3346	SURF1 family
HL653_RS07805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HL653_RS07815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HL653_RS07820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HL653_RS07825	COG0477	Major facilitator Superfamily
HL653_RS07830	COG1231	oxidoreductase activity
HL653_RS07840	COG0443	Heat shock 70 kDa protein
HL653_RS07865	COG4771	TonB-dependent receptor
HL653_RS07875	COG2205	protein histidine kinase activity
HL653_RS07915	COG1566	PFAM secretion protein HlyD family protein
HL653_RS07925	COG1289	transmembrane transporter activity
HL653_RS07970	COG2186	Transcriptional regulator
HL653_RS08000	COG0800	Aldolase
HL653_RS08015	COG0129	dihydroxy-acid dehydratase activity
HL653_RS08025	COG2186	Transcriptional regulator
HL653_RS08035	COG1139	Iron-sulfur cluster binding protein
HL653_RS08040	COG0247	lactate metabolic process
HL653_RS08045	COG0657	acetylesterase activity
HL653_RS08045	COG2755	lipolytic protein G-D-S-L family
HL653_RS08050	COG2755	lipolytic protein G-D-S-L family
HL653_RS08060	COG1414	Transcriptional regulator
HL653_RS08065	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS08110	COG2211	Major facilitator Superfamily
HL653_RS08125	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HL653_RS08135	COG3254	rhamnose metabolic process
HL653_RS08145	COG2755	lipolytic protein G-D-S-L family
HL653_RS08165	COG0837	glucose binding
HL653_RS08170	COG0129	dihydroxy-acid dehydratase activity
HL653_RS08175	COG1619	proteins homologs of microcin C7 resistance protein MccF
HL653_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS08210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL653_RS08210	COG1754	DNA topoisomerase type I activity
HL653_RS08225	COG0009	L-threonylcarbamoyladenylate synthase
HL653_RS08230	COG2188	Transcriptional regulator
HL653_RS08235	COG0778	Nitroreductase
HL653_RS08245	COG1228	amidohydrolase
HL653_RS08250	COG0402	S-adenosylhomocysteine deaminase activity
HL653_RS08255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL653_RS08265	COG0351	phosphomethylpyrimidine kinase
HL653_RS08265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HL653_RS08265	COG0352	thiamine-phosphate diphosphorylase activity
HL653_RS08275	COG0725	ABC transporter, periplasmic molybdate-binding protein
HL653_RS08280	COG4149	molybdate abc transporter
HL653_RS08290	COG0628	permease
HL653_RS08295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL653_RS08310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HL653_RS08320	COG3609	addiction module antidote protein, CC2985 family
HL653_RS08325	COG3668	Plasmid stabilization system
HL653_RS08335	COG1595	DNA-templated transcription, initiation
HL653_RS08350	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HL653_RS08385	COG0300	oxidoreductase activity
HL653_RS08400	COG2205	protein histidine kinase activity
HL653_RS08410	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HL653_RS08415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HL653_RS08440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL653_RS08450	COG0702	epimerase
HL653_RS08480	COG2001	Belongs to the MraZ family
HL653_RS08485	COG0275	rRNA processing
HL653_RS08500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL653_RS08505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HL653_RS08510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL653_RS08515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HL653_RS08530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HL653_RS08535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL653_RS08545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HL653_RS08555	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL653_RS08560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HL653_RS08565	COG0849	cell division
HL653_RS08570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HL653_RS08580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HL653_RS08600	COG0018	arginyl-trna synthetase
HL653_RS08610	COG1472	Belongs to the glycosyl hydrolase 3 family
HL653_RS08620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HL653_RS08625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL653_RS08635	COG1393	Belongs to the ArsC family
HL653_RS08640	COG0439	Biotin carboxylase
HL653_RS08645	COG0511	ligase activity, forming carbon-carbon bonds
HL653_RS08675	COG0477	Major facilitator Superfamily
HL653_RS08690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HL653_RS08695	COG3474	cytochrome
HL653_RS08710	COG1194	a g-specific adenine glycosylase
HL653_RS08730	COG1196	nuclear chromosome segregation
HL653_RS08745	COG0656	L-ascorbic acid biosynthetic process
HL653_RS08750	COG1573	uracil-dna glycosylase
HL653_RS08760	COG1064	alcohol dehydrogenase
HL653_RS08765	COG1902	pentaerythritol trinitrate reductase activity
HL653_RS08770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL653_RS08775	COG4771	TonB-dependent receptor
HL653_RS08810	COG0477	Major facilitator Superfamily
HL653_RS08815	COG1228	amidohydrolase
HL653_RS08830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL653_RS08830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL653_RS08835	COG2032	superoxide dismutase activity
HL653_RS08855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HL653_RS08865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HL653_RS08870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL653_RS08880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL653_RS08905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL653_RS08915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL653_RS08920	COG1846	Transcriptional regulator
HL653_RS08940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HL653_RS08960	COG0277	FAD linked oxidase domain protein
HL653_RS09030	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS09065	COG2852	Protein conserved in bacteria
HL653_RS09080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HL653_RS09090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL653_RS09095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HL653_RS09105	COG0438	transferase activity, transferring glycosyl groups
HL653_RS09125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HL653_RS09130	COG0085	RNA polymerase activity
HL653_RS09150	COG4946	Tricorn protease homolog
HL653_RS09150	COG0823	Involved in the tonB-independent uptake of proteins
HL653_RS09150	COG1506	peptidase
HL653_RS09155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL653_RS09170	COG1278	Cold shock
HL653_RS09195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HL653_RS09205	COG0583	DNA-binding transcription factor activity
HL653_RS09210	COG0667	Aldo Keto reductase
HL653_RS09235	COG0250	Participates in transcription elongation, termination and antitermination
HL653_RS09240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HL653_RS09245	COG0081	regulation of translation
HL653_RS09270	COG1953	Uracil, thiamine, allantoin
HL653_RS09285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HL653_RS09290	COG0222	ribosome binding
HL653_RS09300	COG0546	phosphoglycolate phosphatase activity
HL653_RS09310	COG0151	Belongs to the GarS family
HL653_RS09315	COG1570	exodeoxyribonuclease VII activity
HL653_RS09330	COG2261	transglycosylase associated protein
HL653_RS09345	COG0482	sulfurtransferase activity
HL653_RS09350	COG0693	protein deglycase activity
HL653_RS09355	COG0347	Belongs to the P(II) protein family
HL653_RS09360	COG0174	glutamine synthetase
HL653_RS09370	COG4566	intracellular signal transduction
HL653_RS09375	COG4191	Histidine kinase
HL653_RS09390	COG1959	2 iron, 2 sulfur cluster binding
HL653_RS09395	COG0616	signal peptide processing
HL653_RS09405	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS09450	COG2843	Capsule synthesis protein
HL653_RS09460	COG2304	oxidoreductase activity
HL653_RS09475	COG0714	Associated with various cellular activities
HL653_RS09480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HL653_RS09485	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HL653_RS09510	COG0259	pyridoxamine-phosphate oxidase activity
HL653_RS09530	COG0024	Methionine aminopeptidase
HL653_RS09535	COG1546	Belongs to the CinA family
HL653_RS09535	COG1058	Belongs to the CinA family
HL653_RS09545	COG0625	glutathione transferase activity
HL653_RS09555	COG4957	zinc ion binding
HL653_RS09575	COG4957	zinc ion binding
HL653_RS09580	COG2814	Major facilitator Superfamily
HL653_RS09590	COG0729	surface antigen
HL653_RS09630	COG1132	(ABC) transporter
HL653_RS09645	COG0583	DNA-binding transcription factor activity
HL653_RS09650	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HL653_RS09665	COG3275	phosphorelay sensor kinase activity
HL653_RS09675	COG4774	siderophore transport
HL653_RS09690	COG0584	glycerophosphoryl diester phosphodiesterase
HL653_RS09700	COG0384	phenazine biosynthesis protein PhzF
HL653_RS09710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL653_RS09725	COG3618	amidohydrolase
HL653_RS09735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HL653_RS09740	COG0583	DNA-binding transcription factor activity
HL653_RS09750	COG2159	amidohydrolase
HL653_RS09775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL653_RS09780	COG0667	Aldo Keto reductase
HL653_RS09790	COG1024	Enoyl-CoA hydratase
HL653_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS09810	COG2814	Major facilitator Superfamily
HL653_RS09835	COG0730	response to heat
HL653_RS09840	COG1671	Belongs to the UPF0178 family
HL653_RS09845	COG0494	nUDIX hydrolase
HL653_RS09865	COG0071	Belongs to the small heat shock protein (HSP20) family
HL653_RS09885	COG0318	PFAM AMP-dependent synthetase and ligase
HL653_RS09900	COG0183	Belongs to the thiolase family
HL653_RS09905	COG1024	Enoyl-CoA hydratase
HL653_RS09905	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL653_RS09910	COG1960	acyl-CoA dehydrogenase activity
HL653_RS09920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL653_RS09925	COG0717	Belongs to the dCTP deaminase family
HL653_RS09930	COG0295	cytidine deaminase activity
HL653_RS09935	COG5328	Belongs to the UPF0262 family
HL653_RS09940	COG0305	Participates in initiation and elongation during chromosome replication
HL653_RS09950	COG0175	sulfate reduction
HL653_RS09960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL653_RS09975	COG5001	Diguanylate cyclase
HL653_RS09975	COG3300	MHYT domain
HL653_RS09985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HL653_RS10000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HL653_RS10000	COG0519	Catalyzes the synthesis of GMP from XMP
HL653_RS10005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL653_RS10010	COG2814	Major facilitator Superfamily
HL653_RS10030	COG1696	Membrane protein involved in D-alanine export
HL653_RS10045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL653_RS10080	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HL653_RS10130	COG2223	nitrite transmembrane transporter activity
HL653_RS10135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL653_RS10145	COG0617	tRNA 3'-terminal CCA addition
HL653_RS10210	COG5383	Protein conserved in bacteria
HL653_RS10215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HL653_RS10235	COG0210	DNA helicase
HL653_RS10245	COG0679	Auxin Efflux Carrier
HL653_RS10250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL653_RS10255	COG3800	Transcriptional regulator
HL653_RS10255	COG1396	sequence-specific DNA binding
HL653_RS10270	COG0753	catalase activity
HL653_RS10280	COG0730	response to heat
HL653_RS10300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HL653_RS10315	COG4774	siderophore transport
HL653_RS10320	COG1858	cytochrome C peroxidase
HL653_RS10330	COG4771	TonB-dependent receptor
HL653_RS10350	COG4771	TonB-dependent receptor
HL653_RS10390	COG3246	L-lysine catabolic process to acetate
HL653_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS10405	COG2084	Dehydrogenase
HL653_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS10455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HL653_RS10465	COG3622	Belongs to the hyi family
HL653_RS10510	COG4771	TonB-dependent receptor
HL653_RS10515	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL653_RS10555	COG2814	Major facilitator Superfamily
HL653_RS10560	COG1741	Belongs to the pirin family
HL653_RS10605	COG0625	glutathione transferase activity
HL653_RS10635	COG0025	NhaP-type Na H and K H
HL653_RS10640	COG0586	Pfam SNARE associated Golgi protein
HL653_RS10655	COG0297	glycogen (starch) synthase activity
HL653_RS10745	COG2095	MarC family integral membrane protein
HL653_RS10760	COG0071	Belongs to the small heat shock protein (HSP20) family
HL653_RS10765	COG0071	Belongs to the small heat shock protein (HSP20) family
HL653_RS10785	COG2201	protein-glutamate methylesterase activity
HL653_RS10790	COG3920	Histidine kinase
HL653_RS10800	COG0784	Response regulator, receiver
HL653_RS10800	COG4191	Histidine kinase
HL653_RS10870	COG4993	Dehydrogenase
HL653_RS10910	COG3279	Response regulator of the LytR AlgR family
HL653_RS10935	COG0604	alcohol dehydrogenase
HL653_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS10935	COG3321	synthase
HL653_RS10940	COG0583	DNA-binding transcription factor activity
HL653_RS10960	COG0745	RESPONSE REGULATOR receiver
HL653_RS10970	COG0583	DNA-binding transcription factor activity
HL653_RS10975	COG2267	carboxylic ester hydrolase activity
HL653_RS10980	COG0697	spore germination
HL653_RS10990	COG0596	Alpha beta hydrolase
HL653_RS10995	COG3214	Protein conserved in bacteria
HL653_RS11000	COG0596	Alpha beta hydrolase
HL653_RS11040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL653_RS11080	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS11090	COG2132	Multicopper oxidase
HL653_RS11115	COG4566	intracellular signal transduction
HL653_RS11120	COG4191	Histidine kinase
HL653_RS11190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HL653_RS11195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HL653_RS11210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL653_RS11225	COG0356	it plays a direct role in the translocation of protons across the membrane
HL653_RS11235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HL653_RS11235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL653_RS11240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL653_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS11285	COG1309	transcriptional regulator
HL653_RS11305	COG0405	Gamma-glutamyltransferase
HL653_RS11310	COG1228	amidohydrolase
HL653_RS11315	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS11325	COG1064	alcohol dehydrogenase
HL653_RS11340	COG2271	Major facilitator Superfamily
HL653_RS11345	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS11370	COG2272	Belongs to the type-B carboxylesterase lipase family
HL653_RS11380	COG1472	Belongs to the glycosyl hydrolase 3 family
HL653_RS11395	COG3940	Belongs to the glycosyl hydrolase 43 family
HL653_RS11405	COG3940	Belongs to the glycosyl hydrolase 43 family
HL653_RS11415	COG2211	Major facilitator Superfamily
HL653_RS11450	COG1228	amidohydrolase
HL653_RS11475	COG2186	Transcriptional regulator
HL653_RS11485	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS11495	COG2814	Major facilitator Superfamily
HL653_RS11515	COG3734	2-keto-3-deoxy-galactonokinase
HL653_RS11555	COG1402	creatininase
HL653_RS11570	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HL653_RS11595	COG1846	Transcriptional regulator
HL653_RS11615	COG4771	TonB-dependent receptor
HL653_RS11620	COG2272	Belongs to the type-B carboxylesterase lipase family
HL653_RS11655	COG2855	membrane
HL653_RS11730	COG0582	viral genome integration into host DNA
HL653_RS11755	COG0469	pyruvate kinase activity
HL653_RS11760	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HL653_RS11770	COG4771	TonB-dependent receptor
HL653_RS11775	COG2084	Dehydrogenase
HL653_RS11795	COG1620	l-lactate permease
HL653_RS11920	COG2239	Acts as a magnesium transporter
HL653_RS11930	COG3386	PFAM SMP-30 Gluconolaconase
HL653_RS11935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL653_RS11940	COG1335	isochorismatase
HL653_RS11945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL653_RS11950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL653_RS11955	COG2080	2 iron, 2 sulfur cluster binding
HL653_RS11960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HL653_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS11980	COG2133	pyrroloquinoline quinone binding
HL653_RS11995	COG2205	protein histidine kinase activity
HL653_RS12030	COG3436	PFAM IS66 Orf2 family protein
HL653_RS12040	COG3012	SEC-C Motif Domain Protein
HL653_RS12075	COG1285	pathogenesis
HL653_RS12270	COG0367	asparagine synthase
HL653_RS12325	COG4957	zinc ion binding
HL653_RS12445	COG4974	Belongs to the 'phage' integrase family
HL653_RS12490	COG2824	Alkylphosphonate utilization operon protein PhnA
HL653_RS12495	COG1872	DUF167
HL653_RS12585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HL653_RS12590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL653_RS12615	COG2169	Transcriptional regulator
HL653_RS12655	COG0148	phosphopyruvate hydratase activity
HL653_RS12675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL653_RS12675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL653_RS12680	COG3706	GGDEF domain
HL653_RS12690	COG0308	aminopeptidase N
HL653_RS12710	COG1643	Atp-dependent helicase
HL653_RS12725	COG1435	thymidine kinase activity
HL653_RS12735	COG0142	geranyltranstransferase activity
HL653_RS12740	COG1605	Chorismate mutase
HL653_RS12740	COG0287	Prephenate dehydrogenase
HL653_RS12770	COG1970	mechanosensitive ion channel activity
HL653_RS12810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HL653_RS12820	COG1522	sequence-specific DNA binding
HL653_RS12840	COG0667	Aldo Keto reductase
HL653_RS12845	COG0583	DNA-binding transcription factor activity
HL653_RS12855	COG1506	peptidase
HL653_RS12855	COG0823	Involved in the tonB-independent uptake of proteins
HL653_RS12855	COG4946	Tricorn protease homolog
HL653_RS12870	COG1501	Belongs to the glycosyl hydrolase 31 family
HL653_RS12910	COG4771	TonB-dependent receptor
HL653_RS12915	COG2084	Dehydrogenase
HL653_RS12920	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS12925	COG2271	Major facilitator Superfamily
HL653_RS12940	COG0025	NhaP-type Na H and K H
HL653_RS12980	COG0243	molybdopterin cofactor binding
HL653_RS12985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HL653_RS12990	COG0746	molybdenum cofactor guanylyltransferase activity
HL653_RS13020	COG2132	Multicopper oxidase
HL653_RS13080	COG0481	GTPase activity
HL653_RS13100	COG0123	including yeast histone deacetylase and acetoin utilization protein
HL653_RS13105	COG4191	Histidine kinase
HL653_RS13105	COG0784	Response regulator, receiver
HL653_RS13120	COG1131	(ABC) transporter
HL653_RS13135	COG0312	modulator of DNA gyrase
HL653_RS13140	COG0347	Belongs to the P(II) protein family
HL653_RS13145	COG0004	ammonium transporteR
HL653_RS13150	COG0105	UTP biosynthetic process
HL653_RS13165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HL653_RS13170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HL653_RS13185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HL653_RS13205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HL653_RS13210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HL653_RS13215	COG2326	polyphosphate kinase activity
HL653_RS13225	COG0741	lytic transglycosylase activity
HL653_RS13230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL653_RS13235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HL653_RS13245	COG0784	Response regulator, receiver
HL653_RS13250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HL653_RS13255	COG0477	Major facilitator Superfamily
HL653_RS13260	COG0742	ribosomal rna small subunit methyltransferase
HL653_RS13265	COG1187	pseudouridine synthase activity
HL653_RS13275	COG1301	dicarboxylic acid transport
HL653_RS13295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HL653_RS13305	COG0322	excinuclease ABC activity
HL653_RS13310	COG1381	Involved in DNA repair and RecF pathway recombination
HL653_RS13315	COG3706	GGDEF domain
HL653_RS13330	COG0625	glutathione transferase activity
HL653_RS13360	COG0194	GDP metabolic process
HL653_RS13380	COG0546	phosphoglycolate phosphatase activity
HL653_RS13395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HL653_RS13415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HL653_RS13420	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL653_RS13420	COG0022	dehydrogenase e1 component
HL653_RS13440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HL653_RS13445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HL653_RS13450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL653_RS13455	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HL653_RS13460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HL653_RS13485	COG0039	L-malate dehydrogenase activity
HL653_RS13490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HL653_RS13500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL653_RS13510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL653_RS13530	COG1522	sequence-specific DNA binding
HL653_RS13550	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HL653_RS13555	COG1733	regulation of RNA biosynthetic process
HL653_RS13565	COG2268	Band 7 protein
HL653_RS13575	COG3158	transport of potassium into the cell
HL653_RS13580	COG2354	Protein conserved in bacteria
HL653_RS13635	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HL653_RS13640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HL653_RS13660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL653_RS13665	COG4235	cytochrome complex assembly
HL653_RS13670	COG3186	Phenylalanine-4-hydroxylase
HL653_RS13680	COG1045	serine acetyltransferase
HL653_RS13700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HL653_RS13715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HL653_RS13755	COG1074	ATP-dependent DNA helicase activity
HL653_RS13775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HL653_RS13785	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL653_RS13790	COG0356	it plays a direct role in the translocation of protons across the membrane
HL653_RS13800	COG2003	Belongs to the UPF0758 family
HL653_RS13820	COG0745	RESPONSE REGULATOR receiver
HL653_RS13825	COG2205	protein histidine kinase activity
HL653_RS13850	COG1072	(Pantothenic acid kinase))
HL653_RS13855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HL653_RS13860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HL653_RS13865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HL653_RS13900	COG0653	protein targeting
HL653_RS13915	COG3108	Peptidase M15
HL653_RS13920	COG1376	ErfK ybiS ycfS ynhG family protein
HL653_RS13940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HL653_RS13945	COG0483	inositol monophosphate 1-phosphatase activity
HL653_RS13950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL653_RS13955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL653_RS13960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL653_RS13965	COG0649	NAD binding
HL653_RS13985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HL653_RS13990	COG1034	ATP synthesis coupled electron transport
HL653_RS13995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL653_RS14000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL653_RS14010	COG0713	ATP synthesis coupled electron transport
HL653_RS14025	COG1007	ATP synthesis coupled electron transport
HL653_RS14035	COG2860	membrane
HL653_RS14040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HL653_RS14050	COG2814	Major facilitator Superfamily
HL653_RS14075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL653_RS14080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HL653_RS14130	COG2205	protein histidine kinase activity
HL653_RS14145	COG0659	secondary active sulfate transmembrane transporter activity
HL653_RS14170	COG0583	DNA-binding transcription factor activity
HL653_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS14180	COG0753	catalase activity
HL653_RS14185	COG3038	cytochrome b561
HL653_RS14210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HL653_RS14225	COG1335	isochorismatase
HL653_RS14245	COG1846	Transcriptional regulator
HL653_RS14245	COG1940	carbohydrate kinase activity
HL653_RS14250	COG2814	Major facilitator Superfamily
HL653_RS14290	COG4771	TonB-dependent receptor
HL653_RS14295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL653_RS14300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL653_RS14310	COG0778	Nitroreductase
HL653_RS14315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL653_RS14330	COG4221	oxidoreductase activity
HL653_RS14335	COG0667	Aldo Keto reductase
HL653_RS14350	COG1252	NADH dehydrogenase
HL653_RS14355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HL653_RS14365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL653_RS14370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL653_RS14385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL653_RS14390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HL653_RS14395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HL653_RS14400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL653_RS14405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL653_RS14410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL653_RS14410	COG2169	Transcriptional regulator
HL653_RS14420	COG2990	Protein conserved in bacteria
HL653_RS14435	COG0372	Belongs to the citrate synthase family
HL653_RS14440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL653_RS14445	COG2333	competence protein COMEC
HL653_RS14445	COG0658	competence protein
HL653_RS14450	COG4191	Histidine kinase
HL653_RS14450	COG0784	Response regulator, receiver
HL653_RS14455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL653_RS14475	COG0628	permease
HL653_RS14530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL653_RS14540	COG0126	phosphoglycerate kinase activity
HL653_RS14555	COG3588	fructose-bisphosphate aldolase
HL653_RS14565	COG0352	thiamine-phosphate diphosphorylase activity
HL653_RS14570	COG2203	Gaf domain
HL653_RS14570	COG3706	GGDEF domain
HL653_RS14570	COG4251	negative regulation of phosphorylation
HL653_RS14570	COG5001	Diguanylate cyclase
HL653_RS14590	COG0531	amino acid
HL653_RS14605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HL653_RS14615	COG2827	Endonuclease containing a URI domain
HL653_RS14620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL653_RS14625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HL653_RS14630	COG0698	ribose 5-phosphate isomerase
HL653_RS14645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HL653_RS14660	COG0456	acetyltransferase
HL653_RS14670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HL653_RS14695	COG0772	Belongs to the SEDS family
HL653_RS14710	COG3668	Plasmid stabilization system
HL653_RS14720	COG0643	Histidine kinase
HL653_RS14720	COG2198	Histidine kinase
HL653_RS14725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HL653_RS14730	COG2201	protein-glutamate methylesterase activity
HL653_RS14735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HL653_RS14750	COG2201	protein-glutamate methylesterase activity
HL653_RS14755	COG0835	chemotaxis
HL653_RS14760	COG0840	transmembrane signaling receptor activity
HL653_RS14765	COG4191	Histidine kinase
HL653_RS14785	COG2885	chlorophyll binding
HL653_RS14795	COG1228	amidohydrolase
HL653_RS14940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL653_RS14980	COG3275	phosphorelay sensor kinase activity
HL653_RS14985	COG3279	Response regulator of the LytR AlgR family
HL653_RS14990	COG0066	3-isopropylmalate dehydratase activity
HL653_RS15000	COG0745	RESPONSE REGULATOR receiver
HL653_RS15005	COG0704	Plays a role in the regulation of phosphate uptake
HL653_RS15010	COG5002	protein histidine kinase activity
HL653_RS15015	COG0546	phosphoglycolate phosphatase activity
HL653_RS15020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL653_RS15025	COG5001	Diguanylate cyclase
HL653_RS15025	COG3300	MHYT domain
HL653_RS15035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL653_RS15045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HL653_RS15060	COG2814	Major facilitator Superfamily
HL653_RS15065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HL653_RS15070	COG0753	catalase activity
HL653_RS15105	COG0180	Tryptophanyl-tRNA synthetase
HL653_RS15115	COG0728	peptidoglycan biosynthetic process
HL653_RS15120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HL653_RS15130	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HL653_RS15140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL653_RS15145	COG0625	glutathione transferase activity
HL653_RS15155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HL653_RS15160	COG0706	membrane insertase activity
HL653_RS15165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HL653_RS15170	COG0594	ribonuclease P activity
HL653_RS15175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HL653_RS15185	COG0606	chelatase, subunit chli
HL653_RS15190	COG3152	Membrane
HL653_RS15200	COG0302	gtp cyclohydrolase
HL653_RS15210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HL653_RS15215	COG0571	ribonuclease III activity
HL653_RS15220	COG2010	Cytochrome c
HL653_RS15240	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HL653_RS15265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL653_RS15280	COG0583	DNA-binding transcription factor activity
HL653_RS15300	COG1185	polyribonucleotide nucleotidyltransferase activity
HL653_RS15305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HL653_RS15310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HL653_RS15320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HL653_RS15345	COG2321	neutral zinc metallopeptidase
HL653_RS15360	COG1595	DNA-templated transcription, initiation
HL653_RS15415	COG1446	asparaginase
HL653_RS15425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HL653_RS15460	COG0175	sulfate reduction
HL653_RS15470	COG1218	3'(2'),5'-bisphosphate nucleotidase
HL653_RS15475	COG1733	regulation of RNA biosynthetic process
HL653_RS15480	COG0702	epimerase
HL653_RS15485	COG1301	dicarboxylic acid transport
HL653_RS15490	COG2814	Major facilitator Superfamily
HL653_RS15505	COG0776	regulation of translation
HL653_RS15520	COG0183	Belongs to the thiolase family
HL653_RS15525	COG3243	poly(R)-hydroxyalkanoic acid synthase
HL653_RS15545	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL653_RS15560	COG0284	orotidine-5'-phosphate decarboxylase activity
HL653_RS15575	COG0697	spore germination
HL653_RS15580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL653_RS15590	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HL653_RS15595	COG1138	Cytochrome C-type biogenesis protein
HL653_RS15605	COG3088	subunit of a heme lyase
HL653_RS15620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL653_RS15625	COG0573	inorganic phosphate transmembrane transporter activity
HL653_RS15630	COG0581	inorganic phosphate transmembrane transporter activity
HL653_RS15635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HL653_RS15665	COG1253	flavin adenine dinucleotide binding
HL653_RS15670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HL653_RS15685	COG1702	phosphate starvation-inducible protein PhoH
HL653_RS15690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HL653_RS15700	COG4152	abc transporter atp-binding protein
HL653_RS15705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL653_RS15715	COG0346	lactoylglutathione lyase activity
HL653_RS15730	COG0531	amino acid
HL653_RS15740	COG0140	phosphoribosyl-ATP diphosphatase activity
HL653_RS15745	COG0047	phosphoribosylformylglycinamidine synthase activity
HL653_RS15750	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL653_RS15780	COG0776	regulation of translation
HL653_RS15785	COG0539	negative regulation of cytoplasmic translation
HL653_RS15790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HL653_RS15800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HL653_RS15840	COG1196	nuclear chromosome segregation
HL653_RS15840	COG3264	Mechanosensitive ion channel
HL653_RS15855	COG1501	Belongs to the glycosyl hydrolase 31 family
HL653_RS15870	COG2010	Cytochrome c
HL653_RS15870	COG4993	Dehydrogenase
HL653_RS15885	COG3794	PFAM blue (type 1) copper domain protein
HL653_RS15890	COG2706	6-phosphogluconolactonase activity
HL653_RS15895	COG4993	Dehydrogenase
HL653_RS15900	COG4993	Dehydrogenase
HL653_RS15915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HL653_RS15920	COG1024	Enoyl-CoA hydratase
HL653_RS15925	COG1304	FMN binding
HL653_RS15930	COG2271	Major facilitator Superfamily
HL653_RS15935	COG1228	amidohydrolase
HL653_RS15945	COG2755	lipolytic protein G-D-S-L family
HL653_RS15975	COG2843	Capsule synthesis protein
HL653_RS15985	COG4206	TonB-dependent receptor
HL653_RS16000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL653_RS16010	COG2267	carboxylic ester hydrolase activity
HL653_RS16025	COG2271	Major facilitator Superfamily
HL653_RS16040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL653_RS16050	COG4993	Dehydrogenase
HL653_RS16085	COG0745	RESPONSE REGULATOR receiver
HL653_RS16090	COG0642	Histidine kinase
HL653_RS16125	COG4206	TonB-dependent receptor
HL653_RS16140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL653_RS16155	COG0673	inositol 2-dehydrogenase activity
HL653_RS16165	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HL653_RS16205	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HL653_RS16220	COG3047	cAMP biosynthetic process
HL653_RS16225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL653_RS16230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HL653_RS16235	COG4988	ABC transporter
HL653_RS16245	COG1294	oxidase, subunit
HL653_RS16255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL653_RS16275	COG0557	exoribonuclease II activity
HL653_RS16285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HL653_RS16290	COG3387	PFAM Glycoside hydrolase 15-related
HL653_RS16295	COG1877	trehalose-phosphatase activity
HL653_RS16335	COG0475	glutathione-regulated potassium exporter activity
HL653_RS16340	COG1472	Belongs to the glycosyl hydrolase 3 family
HL653_RS16345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HL653_RS16350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HL653_RS16365	COG2271	Major facilitator Superfamily
HL653_RS16375	COG4771	TonB-dependent receptor
HL653_RS16385	COG3250	beta-galactosidase activity
HL653_RS16395	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS16400	COG2186	Transcriptional regulator
HL653_RS16410	COG3507	Belongs to the glycosyl hydrolase 43 family
HL653_RS16450	COG0534	Mate efflux family protein
HL653_RS16455	COG2066	Belongs to the glutaminase family
HL653_RS16460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HL653_RS16505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL653_RS16545	COG0753	catalase activity
HL653_RS16570	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HL653_RS16575	COG3250	beta-galactosidase activity
HL653_RS16580	COG0400	carboxylic ester hydrolase activity
HL653_RS16585	COG0435	Glutathione S-transferase
HL653_RS16595	COG3038	cytochrome b561
HL653_RS16600	COG2353	YceI-like domain
HL653_RS16605	COG0583	DNA-binding transcription factor activity
HL653_RS16610	COG3384	dioxygenase
HL653_RS16615	COG1620	l-lactate permease
HL653_RS16625	COG0583	DNA-binding transcription factor activity
HL653_RS16645	COG1960	acyl-CoA dehydrogenase activity
HL653_RS16650	COG1024	Enoyl-CoA hydratase
HL653_RS16665	COG4251	negative regulation of phosphorylation
HL653_RS16700	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HL653_RS16720	COG1640	4-alpha-glucanotransferase
HL653_RS16725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HL653_RS16735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HL653_RS16745	COG0297	glycogen (starch) synthase activity
HL653_RS16820	COG0243	molybdopterin cofactor binding
HL653_RS16830	COG2807	transmembrane transport
HL653_RS16865	COG0673	inositol 2-dehydrogenase activity
HL653_RS16870	COG3387	PFAM Glycoside hydrolase 15-related
HL653_RS16880	COG0300	oxidoreductase activity
HL653_RS16895	COG1064	alcohol dehydrogenase
HL653_RS16910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL653_RS16920	COG1136	(ABC) transporter
HL653_RS16920	COG0577	efflux transmembrane transporter activity
HL653_RS16945	COG1609	Transcriptional regulator
HL653_RS16955	COG0667	Aldo Keto reductase
HL653_RS16965	COG1914	H( )-stimulated, divalent metal cation uptake system
HL653_RS16980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL653_RS16990	COG4771	TonB-dependent receptor
HL653_RS17005	COG0033	Phosphoglucomutase
HL653_RS17025	COG0596	Alpha beta hydrolase
HL653_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS17045	COG0753	catalase activity
HL653_RS17055	COG4529	Protein conserved in bacteria
HL653_RS17075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL653_RS17080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL653_RS17085	COG2080	2 iron, 2 sulfur cluster binding
HL653_RS17105	COG0656	L-ascorbic acid biosynthetic process
HL653_RS17110	COG3537	Alpha-1,2-mannosidase
HL653_RS17150	COG0628	permease
HL653_RS17165	COG0776	regulation of translation
HL653_RS17215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL653_RS17220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL653_RS17235	COG0596	Alpha beta hydrolase
HL653_RS17245	COG3547	Transposase (IS116 IS110 IS902 family)
HL653_RS17275	COG2271	Major facilitator Superfamily
HL653_RS17285	COG2207	Transcriptional regulator
HL653_RS17305	COG1309	transcriptional regulator
HL653_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS17385	COG3547	Transposase (IS116 IS110 IS902 family)
HL653_RS17390	COG2207	Transcriptional regulator
HL653_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS17410	COG0519	Catalyzes the synthesis of GMP from XMP
HL653_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS17425	COG0583	DNA-binding transcription factor activity
HL653_RS17455	COG0596	Alpha beta hydrolase
HL653_RS17470	COG3920	Histidine kinase
HL653_RS17475	COG4191	Histidine kinase
HL653_RS17475	COG0784	Response regulator, receiver
HL653_RS17505	COG0596	Alpha beta hydrolase
HL653_RS17505	COG2945	thiolester hydrolase activity
HL653_RS17515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HL653_RS17545	COG4206	TonB-dependent receptor
HL653_RS17585	COG2885	chlorophyll binding
HL653_RS17600	COG2176	DNA-directed DNA polymerase activity
HL653_RS17600	COG5002	protein histidine kinase activity
HL653_RS17620	COG0492	ferredoxin-NADP+ reductase activity
HL653_RS17685	COG0776	regulation of translation
HL653_RS17690	COG2912	Transglutaminase-like superfamily
HL653_RS17710	COG0587	DNA-directed DNA polymerase activity
HL653_RS17715	COG4957	zinc ion binding
HL653_RS17780	COG0840	transmembrane signaling receptor activity
HL653_RS17785	COG0835	chemotaxis
HL653_RS17790	COG2201	protein-glutamate methylesterase activity
HL653_RS17795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HL653_RS17800	COG2198	Histidine kinase
HL653_RS17800	COG0643	Histidine kinase
HL653_RS17845	COG0582	viral genome integration into host DNA
HL653_RS17865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HL653_RS17870	COG0181	hydroxymethylbilane synthase activity
HL653_RS17885	COG0483	inositol monophosphate 1-phosphatase activity
HL653_RS17890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HL653_RS17920	COG2733	membrane
HL653_RS17935	COG2264	protein methyltransferase activity
HL653_RS17940	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS17950	COG2009	succinate dehydrogenase
HL653_RS17955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HL653_RS17980	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS17995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HL653_RS18005	COG2207	Transcriptional regulator
HL653_RS18010	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS18020	COG0288	reversible hydration of carbon dioxide
HL653_RS18025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HL653_RS18030	COG2867	negative regulation of translational initiation
HL653_RS18035	COG1058	Belongs to the CinA family
HL653_RS18035	COG1546	Belongs to the CinA family
HL653_RS18045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HL653_RS18045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HL653_RS18070	COG5000	phosphorelay sensor kinase activity
HL653_RS18075	COG2204	response regulator
HL653_RS18080	COG1923	regulation of RNA biosynthetic process
HL653_RS18085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HL653_RS18100	COG3956	TIGRFAM MazG family protein
HL653_RS18110	COG1595	DNA-templated transcription, initiation
HL653_RS18130	COG0583	DNA-binding transcription factor activity
HL653_RS18145	COG0084	hydrolase, TatD family'
HL653_RS18165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HL653_RS18170	COG1686	Belongs to the peptidase S11 family
HL653_RS18190	COG2853	Lipoprotein
HL653_RS18195	COG0640	Transcriptional regulator
HL653_RS18200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HL653_RS18210	COG1410	methionine synthase
HL653_RS18210	COG0646	methionine synthase
HL653_RS18225	COG4232	protein-disulfide reductase activity
HL653_RS18240	COG2084	Dehydrogenase
HL653_RS18245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HL653_RS18250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HL653_RS18255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL653_RS18290	COG0678	peroxiredoxin activity
HL653_RS18295	COG1127	ABC transporter
HL653_RS18300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HL653_RS18305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HL653_RS18310	COG1611	Belongs to the LOG family
HL653_RS18325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL653_RS18330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HL653_RS18340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HL653_RS18350	COG4206	TonB-dependent receptor
HL653_RS18360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL653_RS18365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HL653_RS18375	COG0028	Belongs to the TPP enzyme family
HL653_RS18380	COG0166	Belongs to the GPI family
HL653_RS18385	COG0681	Belongs to the peptidase S26 family
HL653_RS18425	COG0842	Transport permease protein
HL653_RS18440	COG0187	DNA topoisomerase II activity
HL653_RS18450	COG0583	DNA-binding transcription factor activity
HL653_RS18455	COG2967	ApaG domain
HL653_RS18465	COG0386	Belongs to the glutathione peroxidase family
HL653_RS18475	COG0473	3-isopropylmalate dehydrogenase activity
HL653_RS18495	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HL653_RS18510	COG4771	TonB-dependent receptor
HL653_RS18550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HL653_RS18555	COG0156	8-amino-7-oxononanoate synthase activity
HL653_RS18565	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL653_RS18575	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HL653_RS18580	COG0438	transferase activity, transferring glycosyl groups
HL653_RS18590	COG0215	cysteine-tRNA ligase activity
HL653_RS18605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL653_RS18610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HL653_RS18615	COG0509	glycine decarboxylation via glycine cleavage system
HL653_RS18620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HL653_RS18630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL653_RS18635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HL653_RS18640	COG0328	RNA-DNA hybrid ribonuclease activity
HL653_RS18660	COG4964	Belongs to the GSP D family
HL653_RS18700	COG0574	Belongs to the PEP-utilizing enzyme family
HL653_RS18700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL653_RS18705	COG0751	glycine-tRNA ligase activity
HL653_RS18710	COG0752	glycyl-tRNA synthetase alpha subunit
HL653_RS18725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HL653_RS18730	COG0193	aminoacyl-tRNA hydrolase activity
HL653_RS18740	COG0456	acetyltransferase
HL653_RS18780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HL653_RS18805	COG3590	peptidase
HL653_RS18815	COG0527	aspartate kinase activity
HL653_RS18830	COG1278	Cold shock
HL653_RS18855	COG2070	2-Nitropropane dioxygenase
HL653_RS18865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL653_RS18880	COG0037	tRNA processing
HL653_RS18915	COG2951	lytic endotransglycosylase activity
HL653_RS18940	COG0254	rRNA binding
HL653_RS18945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL653_RS18960	COG0750	zinc metalloprotease
HL653_RS18965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HL653_RS18975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL653_RS18980	COG0233	cytoplasmic translational termination
HL653_RS18985	COG0528	UMP kinase activity
HL653_RS18990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HL653_RS18995	COG0052	Belongs to the universal ribosomal protein uS2 family
HL653_RS19010	COG0688	phosphatidylethanolamine metabolic process
HL653_RS19015	COG0538	isocitrate dehydrogenase activity
HL653_RS19025	COG0583	DNA-binding transcription factor activity
HL653_RS19050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL653_RS19055	COG0519	Catalyzes the synthesis of GMP from XMP
HL653_RS19070	COG2957	Belongs to the agmatine deiminase family
HL653_RS19085	COG1573	uracil-dna glycosylase
HL653_RS19090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HL653_RS19110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HL653_RS19115	COG3781	membrane
HL653_RS19125	COG3781	membrane
HL653_RS19135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL653_RS19150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HL653_RS19155	COG0596	Alpha beta hydrolase
HL653_RS19180	COG1136	(ABC) transporter
HL653_RS19180	COG0577	efflux transmembrane transporter activity
HL653_RS19185	COG1136	(ABC) transporter
HL653_RS19185	COG0577	efflux transmembrane transporter activity
HL653_RS19195	COG1136	(ABC) transporter
HL653_RS19195	COG0577	efflux transmembrane transporter activity
HL653_RS19200	COG0577	efflux transmembrane transporter activity
HL653_RS19200	COG1136	(ABC) transporter
HL653_RS19215	COG0583	DNA-binding transcription factor activity
HL653_RS19225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL653_RS19235	COG0432	Pfam Uncharacterised protein family UPF0047
HL653_RS19245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HL653_RS19250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HL653_RS19255	COG0196	riboflavin kinase activity
HL653_RS19260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL653_RS19275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HL653_RS19280	COG2003	Belongs to the UPF0758 family
HL653_RS19290	COG3023	N-Acetylmuramoyl-L-alanine amidase
HL653_RS19300	COG2201	protein-glutamate methylesterase activity
HL653_RS19305	COG0745	RESPONSE REGULATOR receiver
HL653_RS19315	COG0643	Histidine kinase
HL653_RS19315	COG2198	Histidine kinase
HL653_RS19315	COG0784	Response regulator, receiver
HL653_RS19330	COG0564	pseudouridine synthase activity
HL653_RS19335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL653_RS19395	COG1278	Cold shock
HL653_RS19410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HL653_RS19410	COG1793	dna ligase
HL653_RS19415	COG5487	UPF0391 membrane protein
HL653_RS19420	COG0783	Belongs to the Dps family
HL653_RS19430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL653_RS19440	COG1741	Belongs to the pirin family
HL653_RS19445	COG1741	Belongs to the pirin family
HL653_RS19455	COG0583	DNA-binding transcription factor activity
HL653_RS19460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL653_RS19465	COG2885	chlorophyll binding
HL653_RS19470	COG0823	Involved in the tonB-independent uptake of proteins
HL653_RS19490	COG0824	Thioesterase
HL653_RS19535	COG0457	Tetratricopeptide repeat
HL653_RS19565	COG0612	Peptidase, M16
HL653_RS19575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HL653_RS19575	COG0662	Cupin 2, conserved barrel domain protein
HL653_RS19595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL653_RS19605	COG2852	Protein conserved in bacteria
HL653_RS19620	COG0012	GTP binding
HL653_RS19625	COG2030	dehydratase
HL653_RS19625	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS19635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HL653_RS19650	COG0385	Bile acid
HL653_RS19655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HL653_RS19660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HL653_RS19670	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HL653_RS19690	COG0659	secondary active sulfate transmembrane transporter activity
HL653_RS19700	COG2234	aminopeptidase activity
HL653_RS19720	COG2866	Carboxypeptidase
HL653_RS19730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL653_RS19735	COG0469	pyruvate kinase activity
HL653_RS19750	COG2814	Major facilitator Superfamily
HL653_RS19770	COG0131	Imidazoleglycerol-phosphate dehydratase
HL653_RS19775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL653_RS19780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HL653_RS19785	COG0107	imidazoleglycerol-phosphate synthase activity
HL653_RS19795	COG3706	GGDEF domain
HL653_RS19800	COG0745	RESPONSE REGULATOR receiver
HL653_RS19805	COG2205	protein histidine kinase activity
HL653_RS19810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HL653_RS19815	COG1660	Displays ATPase and GTPase activities
HL653_RS19820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL653_RS19820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL653_RS19825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL653_RS19830	COG5001	Diguanylate cyclase
HL653_RS19830	COG3300	MHYT domain
HL653_RS19835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL653_RS19840	COG5001	Diguanylate cyclase
HL653_RS19840	COG3300	MHYT domain
HL653_RS19845	COG0745	RESPONSE REGULATOR receiver
HL653_RS19850	COG2205	protein histidine kinase activity
HL653_RS19850	COG2198	Histidine kinase
HL653_RS19850	COG0784	Response regulator, receiver
HL653_RS19855	COG2205	protein histidine kinase activity
HL653_RS19855	COG2198	Histidine kinase
HL653_RS19855	COG0784	Response regulator, receiver
HL653_RS19885	COG0251	oxidation-reduction process
HL653_RS19890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HL653_RS19900	COG0588	phosphoglycerate mutase activity
HL653_RS19905	COG1733	regulation of RNA biosynthetic process
HL653_RS19915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL653_RS19920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HL653_RS19920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HL653_RS19925	COG0129	dihydroxy-acid dehydratase activity
HL653_RS19940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HL653_RS19960	COG0741	lytic transglycosylase activity
HL653_RS19965	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL653_RS19995	COG1160	GTP binding
HL653_RS20000	COG3239	Fatty acid desaturase
HL653_RS20020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL653_RS20035	COG0505	Belongs to the CarA family
HL653_RS20050	COG0358	DNA primase activity
HL653_RS20055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL653_RS20065	COG2814	Major facilitator Superfamily
HL653_RS20075	COG4974	Belongs to the 'phage' integrase family
HL653_RS20085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HL653_RS20115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL653_RS20120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL653_RS20140	COG1492	cobalamin metabolic process
HL653_RS20150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HL653_RS20160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HL653_RS20180	COG0800	Aldolase
HL653_RS20205	COG2272	Belongs to the type-B carboxylesterase lipase family
HL653_RS20215	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS20220	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HL653_RS20225	COG1904	glucuronate isomerase
HL653_RS20230	COG1609	Transcriptional regulator
HL653_RS20235	COG2721	sulfolactate sulfo-lyase activity
HL653_RS20240	COG0246	Mannitol dehydrogenase
HL653_RS20250	COG2271	Major facilitator Superfamily
HL653_RS20270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HL653_RS20275	COG3178	'Phosphotransferase
HL653_RS20280	COG0802	atpase or kinase
HL653_RS20285	COG2205	protein histidine kinase activity
HL653_RS20290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HL653_RS20300	COG1678	Uncharacterized ACR, COG1678
HL653_RS20305	COG0678	peroxiredoxin activity
HL653_RS20310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL653_RS20315	COG3706	GGDEF domain
HL653_RS20335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HL653_RS20340	COG0268	Binds directly to 16S ribosomal RNA
HL653_RS20345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HL653_RS20350	COG2226	methyltransferase
HL653_RS20365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL653_RS20370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HL653_RS20375	COG0756	dUTP diphosphatase activity
HL653_RS20380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL653_RS20400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL653_RS20405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL653_RS20410	COG0740	serine-type endopeptidase activity
HL653_RS20420	COG0463	Glycosyl transferase, family 2
HL653_RS20435	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL653_RS20460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL653_RS20475	COG2244	polysaccharide biosynthetic process
HL653_RS20480	COG0154	amidase activity
HL653_RS20485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL653_RS20500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HL653_RS20505	COG0540	Belongs to the ATCase OTCase family
HL653_RS20510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL653_RS20520	COG0006	proline dipeptidase activity
HL653_RS20525	COG1312	Catalyzes the dehydration of D-mannonate
HL653_RS20535	COG2271	Major facilitator Superfamily
HL653_RS20540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL653_RS20550	COG0583	DNA-binding transcription factor activity
HL653_RS20555	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS20565	COG0668	transmembrane transport
HL653_RS20610	COG0596	Alpha beta hydrolase
HL653_RS20625	COG0671	phosphoesterase, PA-phosphatase related
HL653_RS20635	COG4771	TonB-dependent receptor
HL653_RS20685	COG0823	Involved in the tonB-independent uptake of proteins
HL653_RS20685	COG1506	peptidase
HL653_RS20685	COG4946	Tricorn protease homolog
HL653_RS20715	COG4771	TonB-dependent receptor
HL653_RS20725	COG4191	Histidine kinase
HL653_RS20755	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS20760	COG2207	Transcriptional regulator
HL653_RS20765	COG4221	oxidoreductase activity
HL653_RS20770	COG3250	beta-galactosidase activity
HL653_RS20780	COG3401	FG-GAP repeat protein
HL653_RS20785	COG2755	lipolytic protein G-D-S-L family
HL653_RS20785	COG3401	FG-GAP repeat protein
HL653_RS20790	COG4206	TonB-dependent receptor
HL653_RS20825	COG2365	Tyrosine phosphatase family
HL653_RS20830	COG4774	siderophore transport
HL653_RS20870	COG0583	DNA-binding transcription factor activity
HL653_RS20880	COG1595	DNA-templated transcription, initiation
HL653_RS20890	COG4206	TonB-dependent receptor
HL653_RS20895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HL653_RS20980	COG2197	response regulator
HL653_RS20990	COG4794	Type iii secretion
HL653_RS20995	COG4790	Type iii secretion
HL653_RS21010	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL653_RS21015	COG0739	heme binding
HL653_RS21015	COG0741	lytic transglycosylase activity
HL653_RS21015	COG1196	nuclear chromosome segregation
HL653_RS21100	COG1335	isochorismatase
HL653_RS21105	COG0583	DNA-binding transcription factor activity
HL653_RS21115	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS21130	COG2030	dehydratase
HL653_RS21140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HL653_RS21145	COG1960	acyl-CoA dehydrogenase activity
HL653_RS21185	COG4771	TonB-dependent receptor
HL653_RS21210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HL653_RS21215	COG4771	TonB-dependent receptor
HL653_RS21225	COG2814	Major facilitator Superfamily
HL653_RS21240	COG2086	electron transfer activity
HL653_RS21280	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS21300	COG2186	Transcriptional regulator
HL653_RS21310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL653_RS21315	COG2205	protein histidine kinase activity
HL653_RS21325	COG4774	siderophore transport
HL653_RS21335	COG0517	IMP dehydrogenase activity
HL653_RS21340	COG4974	Belongs to the 'phage' integrase family
HL653_RS21350	COG0028	Belongs to the TPP enzyme family
HL653_RS21355	COG3507	Belongs to the glycosyl hydrolase 43 family
HL653_RS21365	COG0584	glycerophosphoryl diester phosphodiesterase
HL653_RS21370	COG1940	carbohydrate kinase activity
HL653_RS21380	COG0583	DNA-binding transcription factor activity
HL653_RS21405	COG2945	thiolester hydrolase activity
HL653_RS21405	COG0596	Alpha beta hydrolase
HL653_RS21440	COG3401	FG-GAP repeat protein
HL653_RS21475	COG1595	DNA-templated transcription, initiation
HL653_RS21530	COG0745	RESPONSE REGULATOR receiver
HL653_RS21545	COG3547	Transposase (IS116 IS110 IS902 family)
HL653_RS21560	COG0641	radical SAM
HL653_RS21585	COG1129	ABC transporter
HL653_RS21605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HL653_RS21620	COG2884	Cell division ATP-binding protein ftsE
HL653_RS21655	COG0629	single-stranded DNA binding
HL653_RS21675	COG0280	phosphate acetyltransferase
HL653_RS21675	COG0281	malic enzyme
HL653_RS21680	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HL653_RS21690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HL653_RS21695	COG1846	Transcriptional regulator
HL653_RS21700	COG1764	response to oxidative stress
HL653_RS21790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL653_RS21795	COG0438	transferase activity, transferring glycosyl groups
HL653_RS21800	COG1192	Involved in chromosome partitioning
HL653_RS21830	COG2271	Major facilitator Superfamily
HL653_RS21835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HL653_RS21840	COG4993	Dehydrogenase
HL653_RS21860	COG4771	TonB-dependent receptor
HL653_RS21870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL653_RS21880	COG2972	Histidine kinase
HL653_RS21890	COG3540	Alkaline phosphatase
HL653_RS21900	COG4251	negative regulation of phosphorylation
HL653_RS21900	COG3706	GGDEF domain
HL653_RS21900	COG5001	Diguanylate cyclase
HL653_RS21900	COG2203	Gaf domain
HL653_RS21905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HL653_RS21915	COG1914	H( )-stimulated, divalent metal cation uptake system
HL653_RS21940	COG4977	sequence-specific DNA binding
HL653_RS21990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HL653_RS22045	COG0202	RNA polymerase activity
HL653_RS22070	COG2176	DNA-directed DNA polymerase activity
HL653_RS22110	COG0517	IMP dehydrogenase activity
HL653_RS22115	COG4974	Belongs to the 'phage' integrase family
HL653_RS22120	COG4957	zinc ion binding
HL653_RS22155	COG1506	peptidase
HL653_RS22155	COG4946	Tricorn protease homolog
HL653_RS22155	COG0823	Involved in the tonB-independent uptake of proteins
HL653_RS22165	COG3712	iron ion homeostasis
HL653_RS22170	COG1595	DNA-templated transcription, initiation
HL653_RS22190	COG0583	DNA-binding transcription factor activity
HL653_RS22200	COG2814	Major facilitator Superfamily
HL653_RS22215	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HL653_RS22240	COG0745	RESPONSE REGULATOR receiver
HL653_RS22245	COG5002	protein histidine kinase activity
HL653_RS22255	COG3794	PFAM blue (type 1) copper domain protein
HL653_RS22260	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS22275	COG0784	Response regulator, receiver
HL653_RS22275	COG2198	Histidine kinase
HL653_RS22275	COG2205	protein histidine kinase activity
HL653_RS22295	COG4993	Dehydrogenase
HL653_RS22295	COG2010	Cytochrome c
HL653_RS22310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HL653_RS22315	COG1234	tRNA 3'-trailer cleavage
HL653_RS22360	COG4993	Dehydrogenase
HL653_RS22370	COG4771	TonB-dependent receptor
HL653_RS22375	COG1414	Transcriptional regulator
HL653_RS22380	COG2271	Major facilitator Superfamily
HL653_RS22395	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS22400	COG2271	Major facilitator Superfamily
HL653_RS22405	COG2814	Major facilitator Superfamily
HL653_RS22405	COG0477	Major facilitator Superfamily
HL653_RS22410	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS22415	COG4948	Mandelate Racemase Muconate Lactonizing
HL653_RS22420	COG0545	Peptidyl-prolyl cis-trans isomerase
HL653_RS22430	COG1408	metallophosphoesterase
HL653_RS22435	COG1278	Cold shock
HL653_RS22440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL653_RS22455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HL653_RS22460	COG1845	cytochrome c oxidase, subunit III
HL653_RS22465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HL653_RS22470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HL653_RS22485	COG0475	glutathione-regulated potassium exporter activity
HL653_RS22485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HL653_RS22490	COG0693	protein deglycase activity
HL653_RS22500	COG2197	response regulator
HL653_RS22510	COG0596	Alpha beta hydrolase
HL653_RS22515	COG1012	belongs to the aldehyde dehydrogenase family
HL653_RS22585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL653_RS22620	COG2948	multi-organism process
HL653_RS22630	COG3701	Conjugal transfer protein
HL653_RS22635	COG3846	protein secretion by the type IV secretion system
HL653_RS22660	COG4957	zinc ion binding
HL653_RS22665	COG3451	type IV secretory pathway VirB4
HL653_RS22675	COG3838	Conjugal transfer protein Trbc
HL653_RS22680	COG4962	Type ii secretion system protein e
HL653_RS22760	COG0784	Response regulator, receiver
HL653_RS22760	COG4191	Histidine kinase
HL653_RS22775	COG0546	phosphoglycolate phosphatase activity
HL653_RS22795	COG0784	Response regulator, receiver
HL653_RS22800	COG4191	Histidine kinase
HL653_RS22800	COG0784	Response regulator, receiver
HL653_RS22810	COG2202	Pas domain
HL653_RS22810	COG3920	Histidine kinase
HL653_RS22840	COG0297	glycogen (starch) synthase activity
HL653_RS22875	COG1132	(ABC) transporter
HL653_RS22960	COG0459	protein refolding
HL653_RS22965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL653_RS22975	COG5425	PFAM Usg family protein
HL653_RS22980	COG0071	Belongs to the small heat shock protein (HSP20) family
HL653_RS22985	COG0071	Belongs to the small heat shock protein (HSP20) family
HL653_RS22990	COG1285	pathogenesis
HL653_RS23025	COG0531	amino acid
HL653_RS23040	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS23045	COG0583	DNA-binding transcription factor activity
HL653_RS23060	COG0784	Response regulator, receiver
HL653_RS23090	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS23100	COG0583	DNA-binding transcription factor activity
HL653_RS23110	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS23120	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HL653_RS23125	COG3547	Transposase (IS116 IS110 IS902 family)
HL653_RS23170	COG2855	membrane
HL653_RS23175	COG0583	DNA-binding transcription factor activity
HL653_RS23185	COG3547	Transposase (IS116 IS110 IS902 family)
HL653_RS23235	COG0129	dihydroxy-acid dehydratase activity
HL653_RS23240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL653_RS23245	COG1621	beta-fructofuranosidase activity
HL653_RS23255	COG0395	ABC-type sugar transport system, permease component
HL653_RS23260	COG1175	transmembrane transport
HL653_RS23325	COG0823	Involved in the tonB-independent uptake of proteins
HL653_RS23325	COG4946	Tricorn protease homolog
HL653_RS23325	COG1506	peptidase
HL653_RS23340	COG1595	DNA-templated transcription, initiation
HL653_RS23370	COG5489	Protein of unknown function (DUF736)
HL653_RS23395	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HL653_RS23450	COG5487	UPF0391 membrane protein
HL653_RS23455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HL653_RS23475	COG0300	oxidoreductase activity
HL653_RS23495	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS23510	COG0753	catalase activity
HL653_RS23515	COG1793	dna ligase
HL653_RS23525	COG1335	isochorismatase
HL653_RS23530	COG1028	Short-chain dehydrogenase reductase Sdr
HL653_RS23545	COG0784	Response regulator, receiver
HL653_RS23565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HL653_RS23580	COG3046	protein related to deoxyribodipyrimidine photolyase
HL653_RS23585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL653_RS23590	COG2080	2 iron, 2 sulfur cluster binding
HL653_RS23595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL653_RS23600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL653_RS23635	COG0582	viral genome integration into host DNA
HL653_RS23655	COG0745	RESPONSE REGULATOR receiver
HL653_RS23665	COG2081	HI0933 family
HL653_RS23695	COG1595	DNA-templated transcription, initiation
HL653_RS23720	COG0438	transferase activity, transferring glycosyl groups
HL653_RS23745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL653_RS23770	COG3830	Belongs to the UPF0237 family
HL653_RS23770	COG0560	Phosphoserine phosphatase
HL653_RS23775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL653_RS23785	COG0028	Belongs to the TPP enzyme family
HL653_RS23790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HL653_RS23810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HL653_RS23825	COG1393	Belongs to the ArsC family
HL653_RS23845	COG1192	Involved in chromosome partitioning