locus-tag	class	description
GVO57_RS00065	COG4191	Histidine kinase
GVO57_RS00090	COG2267	carboxylic ester hydrolase activity
GVO57_RS00095	COG3706	GGDEF domain
GVO57_RS00115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GVO57_RS00125	COG1024	Enoyl-CoA hydratase
GVO57_RS00130	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS00135	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS00160	COG0202	RNA polymerase activity
GVO57_RS00165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GVO57_RS00170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GVO57_RS00175	COG0563	adenylate kinase activity
GVO57_RS00180	COG0201	protein transport
GVO57_RS00185	COG0200	Binds to the 23S rRNA
GVO57_RS00190	COG1841	ribosomal large subunit assembly
GVO57_RS00195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GVO57_RS00200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GVO57_RS00205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GVO57_RS00210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GVO57_RS00215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GVO57_RS00220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GVO57_RS00225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GVO57_RS00230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GVO57_RS00235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GVO57_RS00240	COG0255	Belongs to the universal ribosomal protein uL29 family
GVO57_RS00245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GVO57_RS00250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GVO57_RS00255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GVO57_RS00260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GVO57_RS00265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GVO57_RS00270	COG0089	rRNA binding
GVO57_RS00275	COG0088	Forms part of the polypeptide exit tunnel
GVO57_RS00280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GVO57_RS00285	COG0051	transcription antitermination factor activity, RNA binding
GVO57_RS00290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GVO57_RS00295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GVO57_RS00300	COG0049	tRNA binding
GVO57_RS00305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GVO57_RS00310	COG1959	2 iron, 2 sulfur cluster binding
GVO57_RS00340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GVO57_RS00355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GVO57_RS00360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GVO57_RS00365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GVO57_RS00405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GVO57_RS00410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GVO57_RS00415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GVO57_RS00435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GVO57_RS00440	COG0386	Belongs to the glutathione peroxidase family
GVO57_RS00445	COG0587	DNA-directed DNA polymerase activity
GVO57_RS00460	COG0321	lipoyl(octanoyl) transferase activity
GVO57_RS00480	COG1136	(ABC) transporter
GVO57_RS00490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GVO57_RS00495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GVO57_RS00500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GVO57_RS00505	COG1472	Belongs to the glycosyl hydrolase 3 family
GVO57_RS00515	COG0018	arginyl-trna synthetase
GVO57_RS00520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GVO57_RS00530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GVO57_RS00540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GVO57_RS00545	COG1181	Belongs to the D-alanine--D-alanine ligase family
GVO57_RS00550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GVO57_RS00575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GVO57_RS00585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GVO57_RS00600	COG0275	rRNA processing
GVO57_RS00615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GVO57_RS00625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GVO57_RS00630	COG0316	Belongs to the HesB IscA family
GVO57_RS00635	COG0739	heme binding
GVO57_RS00640	COG2833	Protein of unknown function (DUF455)
GVO57_RS00645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GVO57_RS00650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GVO57_RS00660	COG0784	Response regulator, receiver
GVO57_RS00675	COG0805	protein transport
GVO57_RS00680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GVO57_RS00685	COG0071	Belongs to the small heat shock protein (HSP20) family
GVO57_RS00700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GVO57_RS00705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GVO57_RS00710	COG1420	regulation of RNA biosynthetic process
GVO57_RS00715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GVO57_RS00720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GVO57_RS00730	COG1250	3-hydroxyacyl-CoA dehydrogenase
GVO57_RS00750	COG1940	carbohydrate kinase activity
GVO57_RS00760	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GVO57_RS00765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GVO57_RS00780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GVO57_RS00790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GVO57_RS00810	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GVO57_RS00815	COG1595	DNA-templated transcription, initiation
GVO57_RS00825	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GVO57_RS00830	COG0584	glycerophosphoryl diester phosphodiesterase
GVO57_RS00840	COG0481	GTPase activity
GVO57_RS00860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GVO57_RS00875	COG0840	transmembrane signaling receptor activity
GVO57_RS00885	COG2201	protein-glutamate methylesterase activity
GVO57_RS00895	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GVO57_RS00900	COG0745	RESPONSE REGULATOR receiver
GVO57_RS00905	COG0643	Histidine kinase
GVO57_RS00905	COG2198	Histidine kinase
GVO57_RS00915	COG0745	RESPONSE REGULATOR receiver
GVO57_RS00990	COG0129	dihydroxy-acid dehydratase activity
GVO57_RS01000	COG0837	glucose binding
GVO57_RS01015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GVO57_RS01020	COG0592	DNA-directed DNA polymerase activity
GVO57_RS01035	COG0248	Ppx GppA phosphatase
GVO57_RS01040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GVO57_RS01055	COG1530	ribonuclease E activity
GVO57_RS01065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GVO57_RS01080	COG2003	Belongs to the UPF0758 family
GVO57_RS01090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GVO57_RS01095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GVO57_RS01100	COG0799	negative regulation of ribosome biogenesis
GVO57_RS01105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GVO57_RS01115	COG0793	Belongs to the peptidase S41A family
GVO57_RS01145	COG1131	(ABC) transporter
GVO57_RS01155	COG0312	modulator of DNA gyrase
GVO57_RS01175	COG0004	ammonium transporteR
GVO57_RS01180	COG0347	Belongs to the P(II) protein family
GVO57_RS01195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GVO57_RS01205	COG1758	RNA polymerase activity
GVO57_RS01235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GVO57_RS01240	COG1192	Involved in chromosome partitioning
GVO57_RS01270	COG1201	RNA secondary structure unwinding
GVO57_RS01290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVO57_RS01345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GVO57_RS01350	COG0483	inositol monophosphate 1-phosphatase activity
GVO57_RS01355	COG0312	modulator of DNA gyrase
GVO57_RS01360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GVO57_RS01365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GVO57_RS01375	COG0642	Histidine kinase
GVO57_RS01380	COG0745	RESPONSE REGULATOR receiver
GVO57_RS01410	COG4191	Histidine kinase
GVO57_RS01415	COG4566	intracellular signal transduction
GVO57_RS01420	COG0840	transmembrane signaling receptor activity
GVO57_RS01420	COG2972	Histidine kinase
GVO57_RS01445	COG1157	protein secretion by the type III secretion system
GVO57_RS01450	COG5443	negative regulation of bacterial-type flagellum assembly
GVO57_RS01510	COG4786	Flagellar basal body rod
GVO57_RS01515	COG4786	Flagellar basal body rod
GVO57_RS01525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GVO57_RS01540	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GVO57_RS01550	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GVO57_RS01555	COG2204	response regulator
GVO57_RS01560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GVO57_RS01575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GVO57_RS01585	COG1815	bacterial-type flagellum-dependent cell motility
GVO57_RS01600	COG1706	bacterial-type flagellum-dependent cell motility
GVO57_RS01610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GVO57_RS01615	COG1684	flagellar biosynthetic protein fliR
GVO57_RS01625	COG1677	Flagellar hook-basal body complex protein FliE
GVO57_RS01630	COG1558	bacterial-type flagellum-dependent cell motility
GVO57_RS01645	COG1338	Plays a role in the flagellum-specific transport system
GVO57_RS01660	COG1360	Flagellar Motor Protein
GVO57_RS01670	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GVO57_RS01675	COG0745	RESPONSE REGULATOR receiver
GVO57_RS01680	COG2201	protein-glutamate methylesterase activity
GVO57_RS01695	COG0643	Histidine kinase
GVO57_RS01695	COG2198	Histidine kinase
GVO57_RS01700	COG0745	RESPONSE REGULATOR receiver
GVO57_RS01710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GVO57_RS01715	COG5442	Flagellar protein FlaF
GVO57_RS01725	COG4191	Histidine kinase
GVO57_RS01775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GVO57_RS01780	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GVO57_RS01785	COG1088	dTDP-glucose 4,6-dehydratase activity
GVO57_RS01790	COG1091	dTDP-4-dehydrorhamnose reductase activity
GVO57_RS01810	COG1802	Transcriptional regulator
GVO57_RS01815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GVO57_RS01830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GVO57_RS01835	COG1335	isochorismatase
GVO57_RS01845	COG0625	glutathione transferase activity
GVO57_RS01870	COG0531	amino acid
GVO57_RS01875	COG1024	Enoyl-CoA hydratase
GVO57_RS01880	COG0477	Major facilitator Superfamily
GVO57_RS01885	COG0577	efflux transmembrane transporter activity
GVO57_RS01885	COG1136	(ABC) transporter
GVO57_RS01890	COG1136	(ABC) transporter
GVO57_RS01890	COG0577	efflux transmembrane transporter activity
GVO57_RS01925	COG0196	riboflavin kinase activity
GVO57_RS01945	COG0626	cystathionine gamma-synthase activity
GVO57_RS01955	COG3046	protein related to deoxyribodipyrimidine photolyase
GVO57_RS01960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GVO57_RS01970	COG4269	membrane
GVO57_RS01975	COG0501	Belongs to the peptidase M48B family
GVO57_RS01985	COG0596	Alpha beta hydrolase
GVO57_RS02000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVO57_RS02020	COG0167	dihydroorotate dehydrogenase activity
GVO57_RS02025	COG0280	phosphate acetyltransferase
GVO57_RS02025	COG0281	malic enzyme
GVO57_RS02045	COG2267	carboxylic ester hydrolase activity
GVO57_RS02060	COG0427	acetyl-CoA hydrolase
GVO57_RS02075	COG4566	intracellular signal transduction
GVO57_RS02100	COG2890	protein-(glutamine-N5) methyltransferase activity
GVO57_RS02110	COG0124	histidyl-tRNA synthetase
GVO57_RS02120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GVO57_RS02130	COG0183	Belongs to the thiolase family
GVO57_RS02135	COG0778	Nitroreductase
GVO57_RS02195	COG1607	acyl-coa hydrolase
GVO57_RS02205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GVO57_RS02210	COG0416	fatty acid biosynthetic process
GVO57_RS02215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GVO57_RS02220	COG0776	regulation of translation
GVO57_RS02245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GVO57_RS02260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GVO57_RS02280	COG0010	Belongs to the arginase family
GVO57_RS02330	COG2814	Major facilitator Superfamily
GVO57_RS02385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GVO57_RS02395	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GVO57_RS02405	COG0424	maF-like protein
GVO57_RS02410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GVO57_RS02430	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GVO57_RS02435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GVO57_RS02440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GVO57_RS02445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GVO57_RS02450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GVO57_RS02455	COG0596	Alpha beta hydrolase
GVO57_RS02460	COG1741	Belongs to the pirin family
GVO57_RS02495	COG5265	(ABC) transporter
GVO57_RS02510	COG2086	electron transfer activity
GVO57_RS02515	COG0045	succinate-CoA ligase (ADP-forming) activity
GVO57_RS02570	COG3713	MltA-interacting MipA family protein
GVO57_RS02575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GVO57_RS02605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GVO57_RS02615	COG2154	pterin-4-alpha-carbinolamine dehydratase
GVO57_RS02625	COG4133	protoheme IX ABC transporter activity
GVO57_RS02630	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GVO57_RS02635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GVO57_RS02670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GVO57_RS02680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GVO57_RS02685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GVO57_RS02690	COG0736	holo-[acyl-carrier-protein] synthase activity
GVO57_RS02695	COG0681	Belongs to the peptidase S26 family
GVO57_RS02700	COG0545	Peptidyl-prolyl cis-trans isomerase
GVO57_RS02705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GVO57_RS02720	COG0482	sulfurtransferase activity
GVO57_RS02740	COG0259	pyridoxamine-phosphate oxidase activity
GVO57_RS02745	COG0077	Prephenate dehydratase
GVO57_RS02750	COG3474	cytochrome
GVO57_RS02755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GVO57_RS02765	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GVO57_RS02770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GVO57_RS02785	COG1611	Belongs to the LOG family
GVO57_RS02790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GVO57_RS02795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GVO57_RS02820	COG1194	a g-specific adenine glycosylase
GVO57_RS02850	COG1278	Cold shock
GVO57_RS02875	COG1137	ATPase activity
GVO57_RS02880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GVO57_RS02895	COG1522	sequence-specific DNA binding
GVO57_RS02915	COG0187	DNA topoisomerase II activity
GVO57_RS02940	COG0784	Response regulator, receiver
GVO57_RS02945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GVO57_RS02960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GVO57_RS02965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GVO57_RS02980	COG0235	Class ii aldolase
GVO57_RS03010	COG2733	membrane
GVO57_RS03020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GVO57_RS03030	COG3243	poly(R)-hydroxyalkanoic acid synthase
GVO57_RS03040	COG0436	Aminotransferase
GVO57_RS03060	COG0556	nucleotide-excision repair
GVO57_RS03070	COG1473	amidohydrolase
GVO57_RS03100	COG0730	response to heat
GVO57_RS03120	COG0531	amino acid
GVO57_RS03125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GVO57_RS03135	COG0469	pyruvate kinase activity
GVO57_RS03150	COG3750	Belongs to the UPF0335 family
GVO57_RS03155	COG0217	transcriptional regulatory protein
GVO57_RS03160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GVO57_RS03165	COG0632	four-way junction helicase activity
GVO57_RS03170	COG2255	four-way junction helicase activity
GVO57_RS03175	COG0824	Thioesterase
GVO57_RS03185	COG0848	biopolymer transport protein
GVO57_RS03200	COG2885	chlorophyll binding
GVO57_RS03225	COG3118	belongs to the thioredoxin family
GVO57_RS03235	COG2076	Multidrug Resistance protein
GVO57_RS03250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GVO57_RS03260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GVO57_RS03290	COG0708	Exodeoxyribonuclease III
GVO57_RS03300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GVO57_RS03305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GVO57_RS03325	COG0495	leucyl-tRNA aminoacylation
GVO57_RS03340	COG1475	DNA binding
GVO57_RS03345	COG1192	Involved in chromosome partitioning
GVO57_RS03350	COG0357	Ribosomal RNA small subunit methyltransferase G
GVO57_RS03355	COG0445	tRNA wobble uridine modification
GVO57_RS03360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GVO57_RS03375	COG0861	Integral membrane protein TerC family
GVO57_RS03380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GVO57_RS03390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GVO57_RS03395	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GVO57_RS03400	COG0424	maF-like protein
GVO57_RS03405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GVO57_RS03410	COG0237	dephospho-CoA kinase activity
GVO57_RS03415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GVO57_RS03420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GVO57_RS03425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVO57_RS03455	COG1999	signal sequence binding
GVO57_RS03460	COG2983	Belongs to the UPF0260 family
GVO57_RS03470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GVO57_RS03475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVO57_RS03480	COG0446	pyridine nucleotide-disulphide oxidoreductase
GVO57_RS03495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GVO57_RS03500	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GVO57_RS03505	COG4771	TonB-dependent receptor
GVO57_RS03530	COG0433	COG0433 Predicted ATPase
GVO57_RS03535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GVO57_RS03545	COG0330	HflC and HflK could
GVO57_RS03550	COG0489	protein tyrosine kinase activity
GVO57_RS03560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GVO57_RS03560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GVO57_RS03580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GVO57_RS03580	COG1372	Participates in initiation and elongation during chromosome replication
GVO57_RS03615	COG0739	heme binding
GVO57_RS03635	COG1329	Transcriptional regulator
GVO57_RS03650	COG2239	Acts as a magnesium transporter
GVO57_RS03655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GVO57_RS03660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GVO57_RS03670	COG0546	phosphoglycolate phosphatase activity
GVO57_RS03690	COG0194	GDP metabolic process
GVO57_RS03700	COG0140	phosphoribosyl-ATP diphosphatase activity
GVO57_RS03710	COG0107	imidazoleglycerol-phosphate synthase activity
GVO57_RS03715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GVO57_RS03720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GVO57_RS03725	COG0131	Imidazoleglycerol-phosphate dehydratase
GVO57_RS03735	COG0114	fumarate hydratase activity
GVO57_RS03775	COG0110	maltose O-acetyltransferase activity
GVO57_RS03780	COG4106	trans-aconitate 2-methyltransferase activity
GVO57_RS03885	COG1793	dna ligase
GVO57_RS03885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GVO57_RS03890	COG0483	inositol monophosphate 1-phosphatase activity
GVO57_RS03900	COG2267	carboxylic ester hydrolase activity
GVO57_RS03905	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GVO57_RS03910	COG0583	DNA-binding transcription factor activity
GVO57_RS03915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GVO57_RS03920	COG3002	Belongs to the UPF0753 family
GVO57_RS03945	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS03950	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS03955	COG1946	Acyl-CoA thioesterase
GVO57_RS03965	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS03975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GVO57_RS03985	COG1360	Flagellar Motor Protein
GVO57_RS04020	COG1706	bacterial-type flagellum-dependent cell motility
GVO57_RS04025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GVO57_RS04030	COG4786	Flagellar basal body rod
GVO57_RS04045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GVO57_RS04050	COG1558	bacterial-type flagellum-dependent cell motility
GVO57_RS04105	COG2204	response regulator
GVO57_RS04110	COG1677	Flagellar hook-basal body complex protein FliE
GVO57_RS04120	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GVO57_RS04155	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GVO57_RS04170	COG1987	bacterial-type flagellum assembly
GVO57_RS04205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GVO57_RS04210	COG1435	thymidine kinase activity
GVO57_RS04215	COG4191	Histidine kinase
GVO57_RS04215	COG0784	Response regulator, receiver
GVO57_RS04220	COG4191	Histidine kinase
GVO57_RS04225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GVO57_RS04225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GVO57_RS04230	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GVO57_RS04240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GVO57_RS04250	COG0138	bifunctional purine biosynthesis protein purh
GVO57_RS04255	COG1250	3-hydroxyacyl-CoA dehydrogenase
GVO57_RS04255	COG1024	Enoyl-CoA hydratase
GVO57_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS04285	COG2211	Major facilitator Superfamily
GVO57_RS04295	COG2814	Major facilitator Superfamily
GVO57_RS04300	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS04330	COG0602	queuosine metabolic process
GVO57_RS04345	COG0181	hydroxymethylbilane synthase activity
GVO57_RS04355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GVO57_RS04370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVO57_RS04375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVO57_RS04375	COG2813	Specifically methylates the guanine in position
GVO57_RS04395	COG0072	phenylalanine-tRNA ligase activity
GVO57_RS04400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GVO57_RS04410	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GVO57_RS04430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GVO57_RS04435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GVO57_RS04440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GVO57_RS04470	COG1215	transferase activity, transferring glycosyl groups
GVO57_RS04510	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GVO57_RS04520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GVO57_RS04525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GVO57_RS04535	COG3206	protein involved in exopolysaccharide biosynthesis
GVO57_RS04535	COG0489	protein tyrosine kinase activity
GVO57_RS04565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GVO57_RS04570	COG1494	fructose-1,6-bisphosphatase
GVO57_RS04605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GVO57_RS04610	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GVO57_RS04615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GVO57_RS04620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GVO57_RS04625	COG0137	argininosuccinate synthase activity
GVO57_RS04650	COG0463	Glycosyl transferase, family 2
GVO57_RS04670	COG2095	MarC family integral membrane protein
GVO57_RS04675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GVO57_RS04685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GVO57_RS04725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GVO57_RS04735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GVO57_RS04755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GVO57_RS04765	COG3186	Phenylalanine-4-hydroxylase
GVO57_RS04770	COG2264	protein methyltransferase activity
GVO57_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS04795	COG1053	succinate dehydrogenase
GVO57_RS04810	COG1595	DNA-templated transcription, initiation
GVO57_RS04820	COG0670	Belongs to the BI1 family
GVO57_RS04825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GVO57_RS04830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GVO57_RS04835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GVO57_RS04840	COG0142	geranyltranstransferase activity
GVO57_RS04845	COG1722	exodeoxyribonuclease VII activity
GVO57_RS04855	COG5328	Belongs to the UPF0262 family
GVO57_RS04860	COG0295	cytidine deaminase activity
GVO57_RS04865	COG0717	Belongs to the dCTP deaminase family
GVO57_RS04870	COG1605	Chorismate mutase
GVO57_RS04870	COG0287	Prephenate dehydrogenase
GVO57_RS04875	COG0142	geranyltranstransferase activity
GVO57_RS04880	COG2066	Belongs to the glutaminase family
GVO57_RS04885	COG0745	RESPONSE REGULATOR receiver
GVO57_RS04890	COG0704	Plays a role in the regulation of phosphate uptake
GVO57_RS04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GVO57_RS04920	COG0546	phosphoglycolate phosphatase activity
GVO57_RS04925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GVO57_RS04930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GVO57_RS04940	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GVO57_RS04960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GVO57_RS04965	COG0477	Major facilitator Superfamily
GVO57_RS04995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GVO57_RS05005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GVO57_RS05015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GVO57_RS05020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GVO57_RS05025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GVO57_RS05040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GVO57_RS05045	COG2267	carboxylic ester hydrolase activity
GVO57_RS05055	COG1764	response to oxidative stress
GVO57_RS05070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GVO57_RS05080	COG0586	Pfam SNARE associated Golgi protein
GVO57_RS05085	COG0189	ligase activity
GVO57_RS05090	COG0792	nuclease activity
GVO57_RS05095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GVO57_RS05105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GVO57_RS05110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GVO57_RS05115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GVO57_RS05120	COG0085	RNA polymerase activity
GVO57_RS05125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GVO57_RS05145	COG1648	precorrin-2 dehydrogenase activity
GVO57_RS05145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GVO57_RS05150	COG0019	diaminopimelate decarboxylase activity
GVO57_RS05160	COG0165	Argininosuccinate lyase
GVO57_RS05165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GVO57_RS05170	COG2171	N-acyltransferase activity
GVO57_RS05185	COG0316	Belongs to the HesB IscA family
GVO57_RS05190	COG2151	metal-sulfur cluster biosynthetic enzyme
GVO57_RS05200	COG0719	Fe-S assembly protein
GVO57_RS05205	COG0396	ATPase activity
GVO57_RS05215	COG0719	Fe-S assembly protein
GVO57_RS05230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GVO57_RS05235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GVO57_RS05240	COG0745	RESPONSE REGULATOR receiver
GVO57_RS05250	COG2130	NADP-dependent
GVO57_RS05255	COG2321	neutral zinc metallopeptidase
GVO57_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS05275	COG1473	amidohydrolase
GVO57_RS05285	COG3920	Histidine kinase
GVO57_RS05290	COG2224	Isocitrate lyase
GVO57_RS05330	COG3483	tryptophan 2,3-dioxygenase activity
GVO57_RS05345	COG1253	flavin adenine dinucleotide binding
GVO57_RS05350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GVO57_RS05350	COG3743	rRNA binding
GVO57_RS05360	COG0151	Belongs to the GarS family
GVO57_RS05385	COG4206	TonB-dependent receptor
GVO57_RS05400	COG0542	response to heat
GVO57_RS05410	COG0612	Peptidase, M16
GVO57_RS05420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GVO57_RS05425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GVO57_RS05430	COG0588	phosphoglycerate mutase activity
GVO57_RS05435	COG2866	Carboxypeptidase
GVO57_RS05445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GVO57_RS05450	COG1011	Hydrolase
GVO57_RS05455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GVO57_RS05460	COG4771	TonB-dependent receptor
GVO57_RS05470	COG3275	phosphorelay sensor kinase activity
GVO57_RS05475	COG3279	Response regulator of the LytR AlgR family
GVO57_RS05495	COG0456	acetyltransferase
GVO57_RS05500	COG3746	phosphate-selective porin O and P
GVO57_RS05540	COG0156	8-amino-7-oxononanoate synthase activity
GVO57_RS05550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GVO57_RS05555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GVO57_RS05560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GVO57_RS05590	COG0752	glycyl-tRNA synthetase alpha subunit
GVO57_RS05595	COG0751	glycine-tRNA ligase activity
GVO57_RS05600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GVO57_RS05600	COG0574	Belongs to the PEP-utilizing enzyme family
GVO57_RS05625	COG4964	Belongs to the GSP D family
GVO57_RS05645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GVO57_RS05645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GVO57_RS05650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GVO57_RS05665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GVO57_RS05670	COG0154	amidase activity
GVO57_RS05690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GVO57_RS05710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GVO57_RS05715	COG5001	Diguanylate cyclase
GVO57_RS05720	COG0617	tRNA 3'-terminal CCA addition
GVO57_RS05740	COG0625	glutathione transferase activity
GVO57_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS05750	COG3474	cytochrome
GVO57_RS05760	COG0840	transmembrane signaling receptor activity
GVO57_RS05775	COG1278	Cold shock
GVO57_RS05780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GVO57_RS05810	COG0081	regulation of translation
GVO57_RS05815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GVO57_RS05840	COG5001	Diguanylate cyclase
GVO57_RS05855	COG1278	Cold shock
GVO57_RS05875	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GVO57_RS05880	COG1192	Involved in chromosome partitioning
GVO57_RS05920	COG3920	Histidine kinase
GVO57_RS05920	COG2202	Pas domain
GVO57_RS05925	COG3300	MHYT domain
GVO57_RS05925	COG5001	Diguanylate cyclase
GVO57_RS06000	COG4771	TonB-dependent receptor
GVO57_RS06060	COG4566	intracellular signal transduction
GVO57_RS06065	COG4191	Histidine kinase
GVO57_RS06075	COG0517	IMP dehydrogenase activity
GVO57_RS06085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GVO57_RS06140	COG0745	RESPONSE REGULATOR receiver
GVO57_RS06150	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GVO57_RS06155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GVO57_RS06160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GVO57_RS06195	COG2197	response regulator
GVO57_RS06200	COG4585	Histidine kinase
GVO57_RS06205	COG0842	Transport permease protein
GVO57_RS06210	COG1131	(ABC) transporter
GVO57_RS06230	COG0523	cobalamin synthesis protein
GVO57_RS06315	COG3409	Peptidoglycan-binding domain 1 protein
GVO57_RS06315	COG0793	Belongs to the peptidase S41A family
GVO57_RS06375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVO57_RS06415	COG0745	RESPONSE REGULATOR receiver
GVO57_RS06420	COG2205	protein histidine kinase activity
GVO57_RS06425	COG3590	peptidase
GVO57_RS06435	COG0412	Dienelactone hydrolase
GVO57_RS06440	COG4946	Tricorn protease homolog
GVO57_RS06440	COG0823	Involved in the tonB-independent uptake of proteins
GVO57_RS06440	COG1506	peptidase
GVO57_RS06445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GVO57_RS06465	COG0779	Required for maturation of 30S ribosomal subunits
GVO57_RS06470	COG2133	pyrroloquinoline quinone binding
GVO57_RS06495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GVO57_RS06515	COG2132	Multicopper oxidase
GVO57_RS06535	COG1309	transcriptional regulator
GVO57_RS06545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GVO57_RS06555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GVO57_RS06585	COG1253	flavin adenine dinucleotide binding
GVO57_RS06590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GVO57_RS06595	COG1702	phosphate starvation-inducible protein PhoH
GVO57_RS06600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GVO57_RS06615	COG4957	zinc ion binding
GVO57_RS06630	COG0778	Nitroreductase
GVO57_RS06635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GVO57_RS06645	COG0513	Belongs to the DEAD box helicase family
GVO57_RS06655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GVO57_RS06665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GVO57_RS06675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GVO57_RS06680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GVO57_RS06700	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS06730	COG3047	cAMP biosynthetic process
GVO57_RS06735	COG1573	uracil-dna glycosylase
GVO57_RS06770	COG2884	Cell division ATP-binding protein ftsE
GVO57_RS06800	COG0287	Prephenate dehydrogenase
GVO57_RS06805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GVO57_RS06820	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GVO57_RS06830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GVO57_RS06845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GVO57_RS06845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GVO57_RS06860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GVO57_RS06870	COG1902	pentaerythritol trinitrate reductase activity
GVO57_RS06895	COG0629	single-stranded DNA binding
GVO57_RS06910	COG4771	TonB-dependent receptor
GVO57_RS06915	COG0302	gtp cyclohydrolase
GVO57_RS06920	COG0359	binds to the 23S rRNA
GVO57_RS06925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GVO57_RS06930	COG0360	Binds together with S18 to 16S ribosomal RNA
GVO57_RS06960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GVO57_RS06970	COG0126	phosphoglycerate kinase activity
GVO57_RS06980	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
GVO57_RS06985	COG1830	Aldolase
GVO57_RS06990	COG0352	thiamine-phosphate diphosphorylase activity
GVO57_RS06995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GVO57_RS07000	COG0483	inositol monophosphate 1-phosphatase activity
GVO57_RS07015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVO57_RS07020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVO57_RS07025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVO57_RS07030	COG0649	NAD binding
GVO57_RS07035	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GVO57_RS07050	COG1034	ATP synthesis coupled electron transport
GVO57_RS07055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GVO57_RS07060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GVO57_RS07070	COG0713	ATP synthesis coupled electron transport
GVO57_RS07085	COG1007	ATP synthesis coupled electron transport
GVO57_RS07095	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GVO57_RS07125	COG0183	Belongs to the thiolase family
GVO57_RS07135	COG0800	Aldolase
GVO57_RS07140	COG0336	Belongs to the RNA methyltransferase TrmD family
GVO57_RS07145	COG0335	large ribosomal subunit rRNA binding
GVO57_RS07150	COG0318	PFAM AMP-dependent synthetase and ligase
GVO57_RS07155	COG2030	dehydratase
GVO57_RS07155	COG1012	belongs to the aldehyde dehydrogenase family
GVO57_RS07165	COG0012	GTP binding
GVO57_RS07175	COG0193	aminoacyl-tRNA hydrolase activity
GVO57_RS07180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GVO57_RS07195	COG4695	Portal protein
GVO57_RS07305	COG4373	Mu-like prophage FluMu protein gp28
GVO57_RS07340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GVO57_RS07375	COG3423	Transcriptional regulator
GVO57_RS07380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GVO57_RS07515	COG3750	Belongs to the UPF0335 family
GVO57_RS07530	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GVO57_RS07530	COG2885	chlorophyll binding
GVO57_RS07535	COG2032	superoxide dismutase activity
GVO57_RS07545	COG0343	queuine tRNA-ribosyltransferase activity
GVO57_RS07605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GVO57_RS07615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GVO57_RS07620	COG5001	Diguanylate cyclase
GVO57_RS07620	COG3706	GGDEF domain
GVO57_RS07620	COG2203	Gaf domain
GVO57_RS07620	COG4251	negative regulation of phosphorylation
GVO57_RS07625	COG0539	negative regulation of cytoplasmic translation
GVO57_RS07630	COG0776	regulation of translation
GVO57_RS07640	COG0328	RNA-DNA hybrid ribonuclease activity
GVO57_RS07660	COG0222	ribosome binding
GVO57_RS07665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GVO57_RS07690	COG1301	dicarboxylic acid transport
GVO57_RS07705	COG3275	phosphorelay sensor kinase activity
GVO57_RS07735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GVO57_RS07740	COG0174	glutamine synthetase
GVO57_RS07755	COG0024	Methionine aminopeptidase
GVO57_RS07780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GVO57_RS07810	COG1228	amidohydrolase
GVO57_RS07815	COG2084	Dehydrogenase
GVO57_RS07825	COG0037	tRNA processing
GVO57_RS07860	COG1181	Belongs to the D-alanine--D-alanine ligase family
GVO57_RS07870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GVO57_RS07880	COG1136	(ABC) transporter
GVO57_RS07885	COG0577	efflux transmembrane transporter activity
GVO57_RS07885	COG1136	(ABC) transporter
GVO57_RS07895	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GVO57_RS07900	COG0039	L-malate dehydrogenase activity
GVO57_RS07905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GVO57_RS07915	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVO57_RS07920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVO57_RS07930	COG2860	membrane
GVO57_RS07935	COG1247	-acetyltransferase
GVO57_RS07940	COG0616	signal peptide processing
GVO57_RS07945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GVO57_RS07950	COG0459	protein refolding
GVO57_RS07960	COG1160	GTP binding
GVO57_RS07995	COG0366	Alpha amylase catalytic
GVO57_RS08020	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GVO57_RS08035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GVO57_RS08040	COG1845	cytochrome c oxidase, subunit III
GVO57_RS08045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GVO57_RS08050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GVO57_RS08075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GVO57_RS08080	COG1492	cobalamin metabolic process
GVO57_RS08090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GVO57_RS08100	COG4206	TonB-dependent receptor
GVO57_RS08125	COG0318	PFAM AMP-dependent synthetase and ligase
GVO57_RS08135	COG0521	Mo-molybdopterin cofactor biosynthetic process
GVO57_RS08140	COG0741	lytic transglycosylase activity
GVO57_RS08170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GVO57_RS08185	COG0129	dihydroxy-acid dehydratase activity
GVO57_RS08195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GVO57_RS08230	COG2945	thiolester hydrolase activity
GVO57_RS08240	COG1104	cysteine desulfurase activity
GVO57_RS08255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GVO57_RS08260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GVO57_RS08270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GVO57_RS08275	COG0564	pseudouridine synthase activity
GVO57_RS08305	COG2201	protein-glutamate methylesterase activity
GVO57_RS08310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GVO57_RS08320	COG3023	N-Acetylmuramoyl-L-alanine amidase
GVO57_RS08330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GVO57_RS08345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GVO57_RS08350	COG0840	transmembrane signaling receptor activity
GVO57_RS08355	COG2003	Belongs to the UPF0758 family
GVO57_RS08385	COG0356	it plays a direct role in the translocation of protons across the membrane
GVO57_RS08390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GVO57_RS08395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GVO57_RS08400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GVO57_RS08410	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GVO57_RS08415	COG0322	excinuclease ABC activity
GVO57_RS08420	COG1381	Involved in DNA repair and RecF pathway recombination
GVO57_RS08425	COG0473	3-isopropylmalate dehydrogenase activity
GVO57_RS08435	COG2967	ApaG domain
GVO57_RS08440	COG0583	DNA-binding transcription factor activity
GVO57_RS08465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GVO57_RS08500	COG3156	type II secretion system protein K
GVO57_RS08540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GVO57_RS08550	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GVO57_RS08555	COG1138	Cytochrome C-type biogenesis protein
GVO57_RS08565	COG3088	subunit of a heme lyase
GVO57_RS08570	COG4235	cytochrome complex assembly
GVO57_RS08580	COG0686	Belongs to the AlaDH PNT family
GVO57_RS08590	COG3158	transport of potassium into the cell
GVO57_RS08595	COG0625	glutathione transferase activity
GVO57_RS08605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GVO57_RS08650	COG0840	transmembrane signaling receptor activity
GVO57_RS08665	COG2855	membrane
GVO57_RS08670	COG2030	dehydratase
GVO57_RS08680	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS08685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GVO57_RS08700	COG0431	NADPH-dependent FMN reductase
GVO57_RS08705	COG1218	3'(2'),5'-bisphosphate nucleotidase
GVO57_RS08715	COG1902	pentaerythritol trinitrate reductase activity
GVO57_RS08725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GVO57_RS08730	COG1573	uracil-dna glycosylase
GVO57_RS08735	COG0175	sulfate reduction
GVO57_RS08760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GVO57_RS08760	COG1648	precorrin-2 dehydrogenase activity
GVO57_RS08765	COG1012	belongs to the aldehyde dehydrogenase family
GVO57_RS08770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GVO57_RS08860	COG0557	exoribonuclease II activity
GVO57_RS08880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GVO57_RS08880	COG1754	DNA topoisomerase type I activity
GVO57_RS08890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GVO57_RS08910	COG2226	methyltransferase
GVO57_RS08930	COG0187	DNA topoisomerase II activity
GVO57_RS08945	COG0842	Transport permease protein
GVO57_RS08950	COG0412	Dienelactone hydrolase
GVO57_RS08960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GVO57_RS08965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GVO57_RS08970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GVO57_RS08980	COG4771	TonB-dependent receptor
GVO57_RS08985	COG1012	belongs to the aldehyde dehydrogenase family
GVO57_RS09005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GVO57_RS09015	COG0484	heat shock protein binding
GVO57_RS09025	COG2166	iron-sulfur cluster assembly
GVO57_RS09065	COG1842	Phage shock protein A
GVO57_RS09070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GVO57_RS09075	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GVO57_RS09080	COG2917	probably involved in intracellular septation
GVO57_RS09085	COG0552	protein localization to endoplasmic reticulum
GVO57_RS09090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GVO57_RS09095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GVO57_RS09100	COG5001	Diguanylate cyclase
GVO57_RS09100	COG3300	MHYT domain
GVO57_RS09110	COG0215	cysteine-tRNA ligase activity
GVO57_RS09115	COG0745	RESPONSE REGULATOR receiver
GVO57_RS09115	COG3706	GGDEF domain
GVO57_RS09120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GVO57_RS09125	COG0594	ribonuclease P activity
GVO57_RS09130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GVO57_RS09135	COG0706	membrane insertase activity
GVO57_RS09140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GVO57_RS09145	COG0625	glutathione transferase activity
GVO57_RS09150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GVO57_RS09160	COG1045	serine acetyltransferase
GVO57_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS09190	COG0439	Biotin carboxylase
GVO57_RS09195	COG0511	ligase activity, forming carbon-carbon bonds
GVO57_RS09200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GVO57_RS09215	COG1612	heme a metabolic process
GVO57_RS09230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GVO57_RS09265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GVO57_RS09275	COG0789	Transcriptional regulator
GVO57_RS09280	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS09295	COG4974	Belongs to the 'phage' integrase family
GVO57_RS09300	COG0825	malonyl-CoA metabolic process
GVO57_RS09400	COG0494	nUDIX hydrolase
GVO57_RS09415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GVO57_RS09420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GVO57_RS09485	COG1136	(ABC) transporter
GVO57_RS09485	COG0577	efflux transmembrane transporter activity
GVO57_RS09500	COG4191	Histidine kinase
GVO57_RS09515	COG1116	anion transmembrane transporter activity
GVO57_RS09555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GVO57_RS09570	COG0505	Belongs to the CarA family
GVO57_RS09580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GVO57_RS09615	COG0148	phosphopyruvate hydratase activity
GVO57_RS09625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GVO57_RS09630	COG0022	dehydrogenase e1 component
GVO57_RS09630	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVO57_RS09660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GVO57_RS09670	COG4957	zinc ion binding
GVO57_RS09675	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GVO57_RS09680	COG4235	cytochrome complex assembly
GVO57_RS09685	COG4771	TonB-dependent receptor
GVO57_RS09690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GVO57_RS09695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVO57_RS09700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVO57_RS09705	COG1660	Displays ATPase and GTPase activities
GVO57_RS09715	COG2205	protein histidine kinase activity
GVO57_RS09720	COG0745	RESPONSE REGULATOR receiver
GVO57_RS09730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GVO57_RS09755	COG0435	Glutathione S-transferase
GVO57_RS09760	COG1301	dicarboxylic acid transport
GVO57_RS09765	COG0154	amidase activity
GVO57_RS09780	COG0488	(ABC) transporter
GVO57_RS09790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GVO57_RS09795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GVO57_RS09800	COG5001	Diguanylate cyclase
GVO57_RS09805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GVO57_RS09815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GVO57_RS09825	COG0166	Belongs to the GPI family
GVO57_RS09830	COG0681	Belongs to the peptidase S26 family
GVO57_RS09835	COG0571	ribonuclease III activity
GVO57_RS09840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GVO57_RS09850	COG0047	phosphoribosylformylglycinamidine synthase activity
GVO57_RS09855	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GVO57_RS09860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GVO57_RS09885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GVO57_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS09900	COG1505	serine-type exopeptidase activity
GVO57_RS09910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GVO57_RS09910	COG0519	Catalyzes the synthesis of GMP from XMP
GVO57_RS09915	COG1733	regulation of RNA biosynthetic process
GVO57_RS09920	COG0702	epimerase
GVO57_RS09925	COG1393	Belongs to the ArsC family
GVO57_RS09930	COG0492	ferredoxin-NADP+ reductase activity
GVO57_RS09960	COG0544	peptidyl-prolyl cis-trans isomerase activity
GVO57_RS09965	COG0740	serine-type endopeptidase activity
GVO57_RS09970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GVO57_RS09975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GVO57_RS10000	COG0101	tRNA pseudouridine synthase activity
GVO57_RS10005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GVO57_RS10010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GVO57_RS10015	COG0242	peptide deformylase activity
GVO57_RS10020	COG1322	Protein conserved in bacteria
GVO57_RS10035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GVO57_RS10040	COG0228	four-way junction DNA binding
GVO57_RS10045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GVO57_RS10055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GVO57_RS10065	COG1132	(ABC) transporter
GVO57_RS10070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GVO57_RS10080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GVO57_RS10085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GVO57_RS10090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GVO57_RS10100	COG0009	L-threonylcarbamoyladenylate synthase
GVO57_RS10105	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS10110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GVO57_RS10115	COG2188	Transcriptional regulator
GVO57_RS10120	COG0778	Nitroreductase
GVO57_RS10130	COG3104	oligopeptide transport
GVO57_RS10135	COG0402	S-adenosylhomocysteine deaminase activity
GVO57_RS10150	COG0667	Aldo Keto reductase
GVO57_RS10155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GVO57_RS10160	COG3813	Protein conserved in bacteria
GVO57_RS10165	COG0351	phosphomethylpyrimidine kinase
GVO57_RS10170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GVO57_RS10180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GVO57_RS10195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GVO57_RS10200	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GVO57_RS10205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GVO57_RS10225	COG1904	glucuronate isomerase
GVO57_RS10235	COG0246	Mannitol dehydrogenase
GVO57_RS10245	COG2271	Major facilitator Superfamily
GVO57_RS10270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GVO57_RS10275	COG1414	Transcriptional regulator
GVO57_RS10295	COG2267	carboxylic ester hydrolase activity
GVO57_RS10320	COG2205	protein histidine kinase activity
GVO57_RS10330	COG0745	RESPONSE REGULATOR receiver
GVO57_RS10425	COG0582	viral genome integration into host DNA
GVO57_RS10500	COG2951	lytic endotransglycosylase activity
GVO57_RS10505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GVO57_RS10510	COG0470	DNA polymerase III
GVO57_RS10520	COG0084	hydrolase, TatD family'
GVO57_RS10525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GVO57_RS10525	COG0321	lipoyl(octanoyl) transferase activity
GVO57_RS10560	COG1819	glycosyl
GVO57_RS10580	COG3956	TIGRFAM MazG family protein
GVO57_RS10585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GVO57_RS10610	COG2010	Cytochrome c
GVO57_RS10630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GVO57_RS10640	COG1923	regulation of RNA biosynthetic process
GVO57_RS10645	COG2204	response regulator
GVO57_RS10650	COG5000	phosphorelay sensor kinase activity
GVO57_RS10670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GVO57_RS10670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GVO57_RS10675	COG1058	Belongs to the CinA family
GVO57_RS10675	COG1546	Belongs to the CinA family
GVO57_RS10680	COG2867	negative regulation of translational initiation
GVO57_RS10685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GVO57_RS10695	COG0254	rRNA binding
GVO57_RS10700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GVO57_RS10710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GVO57_RS10715	COG0750	zinc metalloprotease
GVO57_RS10720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GVO57_RS10730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GVO57_RS10735	COG0233	cytoplasmic translational termination
GVO57_RS10740	COG0528	UMP kinase activity
GVO57_RS10745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GVO57_RS10750	COG0052	Belongs to the universal ribosomal protein uS2 family
GVO57_RS10765	COG0688	phosphatidylethanolamine metabolic process
GVO57_RS10800	COG0354	folic acid binding
GVO57_RS10805	COG0418	dihydroorotase activity
GVO57_RS10820	COG2133	pyrroloquinoline quinone binding
GVO57_RS10830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GVO57_RS10865	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GVO57_RS10870	COG0318	PFAM AMP-dependent synthetase and ligase
GVO57_RS10875	COG0183	Belongs to the thiolase family
GVO57_RS10880	COG0183	Belongs to the thiolase family
GVO57_RS10895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GVO57_RS10900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GVO57_RS10905	COG2188	Transcriptional regulator
GVO57_RS10915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GVO57_RS10920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GVO57_RS10920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GVO57_RS10925	COG1263	PTS System
GVO57_RS10925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GVO57_RS10935	COG0583	DNA-binding transcription factor activity
GVO57_RS10945	COG1252	NADH dehydrogenase
GVO57_RS10955	COG3220	belongs to the UPF0276 family
GVO57_RS10970	COG3220	belongs to the UPF0276 family
GVO57_RS11055	COG5377	YqaJ viral recombinase family
GVO57_RS11105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GVO57_RS11120	COG1522	sequence-specific DNA binding
GVO57_RS11130	COG3022	response to hydroperoxide
GVO57_RS11140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GVO57_RS11195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GVO57_RS11205	COG1476	TRANSCRIPTIONal
GVO57_RS11230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GVO57_RS11235	COG4771	TonB-dependent receptor
GVO57_RS11245	COG0667	Aldo Keto reductase
GVO57_RS11275	COG1410	methionine synthase
GVO57_RS11275	COG0646	methionine synthase
GVO57_RS11285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GVO57_RS11295	COG0443	Heat shock 70 kDa protein
GVO57_RS11310	COG0149	triose-phosphate isomerase activity
GVO57_RS11315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GVO57_RS11320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GVO57_RS11325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GVO57_RS11335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GVO57_RS11340	COG0134	indole-3-glycerol-phosphate synthase activity
GVO57_RS11345	COG0315	cyclic pyranopterin monophosphate synthase activity
GVO57_RS11355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GVO57_RS11365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GVO57_RS11370	COG0372	Belongs to the citrate synthase family
GVO57_RS11380	COG2205	protein histidine kinase activity
GVO57_RS11390	COG0747	negative chemotaxis
GVO57_RS11405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GVO57_RS11410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GVO57_RS11425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GVO57_RS11445	COG0066	3-isopropylmalate dehydratase activity
GVO57_RS11450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GVO57_RS11475	COG0028	Belongs to the TPP enzyme family
GVO57_RS11490	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GVO57_RS11495	COG0644	oxidoreductase
GVO57_RS11525	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GVO57_RS11530	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GVO57_RS11535	COG1429	ligase activity, forming nitrogen-metal bonds
GVO57_RS11540	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GVO57_RS11545	COG2226	methyltransferase
GVO57_RS11545	COG1073	alpha beta
GVO57_RS11575	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GVO57_RS11585	COG0156	8-amino-7-oxononanoate synthase activity
GVO57_RS11620	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GVO57_RS11625	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GVO57_RS11630	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GVO57_RS11640	COG0500	methyltransferase
GVO57_RS11670	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GVO57_RS11675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GVO57_RS11680	COG1301	dicarboxylic acid transport
GVO57_RS11685	COG0758	DNA mediated transformation
GVO57_RS11695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GVO57_RS11700	COG0156	8-amino-7-oxononanoate synthase activity
GVO57_RS11720	COG1678	Uncharacterized ACR, COG1678
GVO57_RS11725	COG0678	peroxiredoxin activity
GVO57_RS11730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GVO57_RS11745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GVO57_RS11750	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GVO57_RS11765	COG0671	phosphoesterase, PA-phosphatase related
GVO57_RS11770	COG1228	amidohydrolase
GVO57_RS11775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GVO57_RS11780	COG1607	acyl-coa hydrolase
GVO57_RS11785	COG0508	dehydrogenase complex catalyzes the overall conversion of
GVO57_RS11795	COG1956	GAF domain-containing protein
GVO57_RS11805	COG0564	pseudouridine synthase activity
GVO57_RS11810	COG0655	NAD(P)H dehydrogenase (quinone) activity
GVO57_RS11815	COG1741	Belongs to the pirin family
GVO57_RS11840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GVO57_RS11850	COG0640	Transcriptional regulator
GVO57_RS11855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GVO57_RS11860	COG0730	response to heat
GVO57_RS11870	COG0653	protein targeting
GVO57_RS11880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GVO57_RS11890	COG1074	ATP-dependent DNA helicase activity
GVO57_RS11900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GVO57_RS11905	COG3178	'Phosphotransferase
GVO57_RS11910	COG0802	atpase or kinase
GVO57_RS11915	COG2205	protein histidine kinase activity
GVO57_RS11930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GVO57_RS11960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GVO57_RS11965	COG1127	ABC transporter
GVO57_RS11980	COG0308	aminopeptidase N
GVO57_RS11985	COG0583	DNA-binding transcription factor activity
GVO57_RS11990	COG1132	(ABC) transporter
GVO57_RS12005	COG0183	Belongs to the thiolase family
GVO57_RS12020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GVO57_RS12035	COG0698	ribose 5-phosphate isomerase
GVO57_RS12040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GVO57_RS12045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GVO57_RS12065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GVO57_RS12075	COG2957	Belongs to the agmatine deiminase family
GVO57_RS12100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GVO57_RS12110	COG0113	porphobilinogen synthase activity
GVO57_RS12115	COG1597	lipid kinase activity
GVO57_RS12120	COG0534	Mate efflux family protein
GVO57_RS12125	COG0525	valine-tRNA ligase activity
GVO57_RS12140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GVO57_RS12155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GVO57_RS12180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GVO57_RS12190	COG1024	Enoyl-CoA hydratase
GVO57_RS12200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GVO57_RS12220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GVO57_RS12225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GVO57_RS12240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GVO57_RS12250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GVO57_RS12255	COG3963	phosphatidate phosphatase activity
GVO57_RS12300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GVO57_RS12305	COG1846	Transcriptional regulator
GVO57_RS12310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GVO57_RS12320	COG3706	GGDEF domain
GVO57_RS12320	COG0745	RESPONSE REGULATOR receiver
GVO57_RS12335	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GVO57_RS12340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GVO57_RS12360	COG3876	Protein conserved in bacteria
GVO57_RS12370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GVO57_RS12395	COG1051	belongs to the nudix hydrolase family
GVO57_RS12410	COG3724	N-succinylarginine dihydrolase activity
GVO57_RS12435	COG0540	Belongs to the ATCase OTCase family
GVO57_RS12455	COG1192	Involved in chromosome partitioning
GVO57_RS12470	COG0560	Phosphoserine phosphatase
GVO57_RS12475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GVO57_RS12490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GVO57_RS12495	COG2353	YceI-like domain
GVO57_RS12500	COG2200	EAL domain
GVO57_RS12525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GVO57_RS12530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GVO57_RS12535	COG2363	Small membrane protein
GVO57_RS12580	COG0133	tryptophan synthase activity
GVO57_RS12585	COG0159	tryptophan synthase activity
GVO57_RS12590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GVO57_RS12595	COG0285	dihydrofolate synthase activity
GVO57_RS12605	COG2203	Gaf domain
GVO57_RS12605	COG4251	negative regulation of phosphorylation
GVO57_RS12605	COG5001	Diguanylate cyclase
GVO57_RS12605	COG3706	GGDEF domain
GVO57_RS12620	COG4395	Tim44
GVO57_RS12625	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GVO57_RS12630	COG0728	peptidoglycan biosynthetic process
GVO57_RS12635	COG0180	Tryptophanyl-tRNA synthetase
GVO57_RS12645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GVO57_RS12650	COG0268	Binds directly to 16S ribosomal RNA
GVO57_RS12655	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS12660	COG1960	acyl-CoA dehydrogenase activity
GVO57_RS12670	COG0105	UTP biosynthetic process
GVO57_RS12680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GVO57_RS12700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GVO57_RS12715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GVO57_RS12720	COG0741	lytic transglycosylase activity
GVO57_RS12735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GVO57_RS12740	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GVO57_RS12750	COG0248	Ppx GppA phosphatase
GVO57_RS12755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GVO57_RS12770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GVO57_RS12775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GVO57_RS12790	COG0183	Belongs to the thiolase family
GVO57_RS12810	COG2308	Evidence 4 Homologs of previously reported genes of
GVO57_RS12840	COG0529	Catalyzes the synthesis of activated sulfate
GVO57_RS12840	COG2895	sulfate adenylyltransferase (ATP) activity
GVO57_RS12890	COG0606	chelatase, subunit chli
GVO57_RS12895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GVO57_RS12900	COG0450	alkyl hydroperoxide reductase
GVO57_RS12905	COG0583	DNA-binding transcription factor activity
GVO57_RS12910	COG0314	molybdopterin synthase activity
GVO57_RS12945	COG1609	Transcriptional regulator
GVO57_RS12950	COG2271	Major facilitator Superfamily
GVO57_RS12955	COG4771	TonB-dependent receptor
GVO57_RS12975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GVO57_RS12985	COG2986	histidine ammonia-lyase
GVO57_RS12990	COG1228	amidohydrolase
GVO57_RS13005	COG2814	Major facilitator Superfamily
GVO57_RS13040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GVO57_RS13045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GVO57_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS13055	COG0123	including yeast histone deacetylase and acetoin utilization protein
GVO57_RS13060	COG0415	Belongs to the DNA photolyase family
GVO57_RS13080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GVO57_RS13085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GVO57_RS13120	COG1187	pseudouridine synthase activity
GVO57_RS13125	COG0742	ribosomal rna small subunit methyltransferase
GVO57_RS13130	COG3422	double-strand break repair
GVO57_RS13145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GVO57_RS13165	COG0768	penicillin binding
GVO57_RS13180	COG4152	abc transporter atp-binding protein
GVO57_RS13205	COG1477	protein flavinylation
GVO57_RS13210	COG3128	pkhd-type hydroxylase
GVO57_RS13215	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GVO57_RS13220	COG4774	siderophore transport
GVO57_RS13245	COG2272	Belongs to the type-B carboxylesterase lipase family
GVO57_RS13255	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS13265	COG1609	Transcriptional regulator
GVO57_RS13300	COG2365	Tyrosine phosphatase family
GVO57_RS13315	COG0523	cobalamin synthesis protein
GVO57_RS13320	COG3706	GGDEF domain
GVO57_RS13365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GVO57_RS13380	COG1414	Transcriptional regulator
GVO57_RS13420	COG1902	pentaerythritol trinitrate reductase activity
GVO57_RS13425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GVO57_RS13440	COG0765	amino acid transport
GVO57_RS13445	COG0765	amino acid transport
GVO57_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
GVO57_RS13475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GVO57_RS13610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GVO57_RS13635	COG0582	viral genome integration into host DNA
GVO57_RS13660	COG2832	Protein of unknown function (DUF454)
GVO57_RS13665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GVO57_RS13675	COG4191	Histidine kinase
GVO57_RS13680	COG0745	RESPONSE REGULATOR receiver
GVO57_RS13715	COG0203	ribosomal protein L17
GVO57_RS13725	COG1228	amidohydrolase
GVO57_RS13735	COG0488	(ABC) transporter
GVO57_RS13740	COG1136	(ABC) transporter
GVO57_RS13755	COG2755	lipolytic protein G-D-S-L family
GVO57_RS13760	COG4181	ATPase activity
GVO57_RS13795	COG1968	undecaprenyl-diphosphatase activity
GVO57_RS13850	COG0754	glutathionylspermidine amidase activity
GVO57_RS13870	COG2070	2-Nitropropane dioxygenase
GVO57_RS13895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GVO57_RS13900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GVO57_RS13905	COG1185	polyribonucleotide nucleotidyltransferase activity
GVO57_RS13920	COG2801	Transposase and inactivated derivatives
GVO57_RS13930	COG1970	mechanosensitive ion channel activity
GVO57_RS14035	COG0745	RESPONSE REGULATOR receiver
GVO57_RS14055	COG4957	zinc ion binding
GVO57_RS14120	COG3550	peptidyl-serine autophosphorylation
GVO57_RS14190	COG4691	Plasmid stability protein
GVO57_RS14210	COG1322	Protein conserved in bacteria
GVO57_RS14285	COG3436	PFAM IS66 Orf2 family protein
GVO57_RS14360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GVO57_RS14375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GVO57_RS14380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GVO57_RS14440	COG2003	Belongs to the UPF0758 family
GVO57_RS14490	COG3279	Response regulator of the LytR AlgR family
GVO57_RS14495	COG1770	oligopeptidase
GVO57_RS14500	COG1770	oligopeptidase
GVO57_RS14510	COG1794	racemase activity, acting on amino acids and derivatives