locus-tag	class	description
H5J25_RS00040	COG1230	cation diffusion facilitator family transporter
H5J25_RS00055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5J25_RS00135	COG0318	PFAM AMP-dependent synthetase and ligase
H5J25_RS00165	COG4181	ATPase activity
H5J25_RS00275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5J25_RS00275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5J25_RS00285	COG2814	Major facilitator Superfamily
H5J25_RS00300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5J25_RS00305	COG3958	Transketolase
H5J25_RS00310	COG3959	Transketolase, thiamine diphosphate binding domain
H5J25_RS00315	COG1349	DNA-binding transcription factor activity
H5J25_RS00320	COG1082	Xylose isomerase domain protein TIM barrel
H5J25_RS00325	COG1304	FMN binding
H5J25_RS00340	COG0277	FAD linked oxidase domain protein
H5J25_RS00345	COG0247	lactate metabolic process
H5J25_RS00360	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS00370	COG3250	beta-galactosidase activity
H5J25_RS00380	COG2271	Major facilitator Superfamily
H5J25_RS00390	COG1850	ribulose-bisphosphate carboxylase activity
H5J25_RS00400	COG2186	Transcriptional regulator
H5J25_RS00410	COG3940	Belongs to the glycosyl hydrolase 43 family
H5J25_RS00420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5J25_RS00435	COG1129	ABC transporter
H5J25_RS00440	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5J25_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS00540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5J25_RS00565	COG2851	Citrate transporter
H5J25_RS00580	COG0745	RESPONSE REGULATOR receiver
H5J25_RS00585	COG0642	Histidine kinase
H5J25_RS00655	COG4977	sequence-specific DNA binding
H5J25_RS00655	COG1917	Cupin 2, conserved barrel domain protein
H5J25_RS00665	COG4771	TonB-dependent receptor
H5J25_RS00675	COG0745	RESPONSE REGULATOR receiver
H5J25_RS00680	COG2205	protein histidine kinase activity
H5J25_RS00685	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H5J25_RS00690	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H5J25_RS00710	COG1285	pathogenesis
H5J25_RS00715	COG4993	Dehydrogenase
H5J25_RS00725	COG0471	metal ion transport
H5J25_RS00725	COG3273	potassium ion transport
H5J25_RS00735	COG2130	NADP-dependent
H5J25_RS00745	COG4771	TonB-dependent receptor
H5J25_RS00760	COG2814	Major facilitator Superfamily
H5J25_RS00780	COG0745	RESPONSE REGULATOR receiver
H5J25_RS00785	COG2205	protein histidine kinase activity
H5J25_RS00790	COG3920	Histidine kinase
H5J25_RS00800	COG4771	TonB-dependent receptor
H5J25_RS00805	COG0277	FAD linked oxidase domain protein
H5J25_RS00810	COG3540	Alkaline phosphatase
H5J25_RS00820	COG2885	chlorophyll binding
H5J25_RS00840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5J25_RS00860	COG2814	Major facilitator Superfamily
H5J25_RS00870	COG1408	metallophosphoesterase
H5J25_RS00880	COG0745	RESPONSE REGULATOR receiver
H5J25_RS00885	COG0784	Response regulator, receiver
H5J25_RS00890	COG5002	protein histidine kinase activity
H5J25_RS00895	COG2176	DNA-directed DNA polymerase activity
H5J25_RS00895	COG5002	protein histidine kinase activity
H5J25_RS00900	COG0137	argininosuccinate synthase activity
H5J25_RS00920	COG0275	rRNA processing
H5J25_RS00945	COG0583	DNA-binding transcription factor activity
H5J25_RS00960	COG2239	Acts as a magnesium transporter
H5J25_RS00990	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H5J25_RS00995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5J25_RS01010	COG1496	oxidoreductase activity
H5J25_RS01025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5J25_RS01030	COG0318	PFAM AMP-dependent synthetase and ligase
H5J25_RS01040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5J25_RS01045	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS01060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5J25_RS01070	COG0590	tRNA wobble adenosine to inosine editing
H5J25_RS01075	COG2885	chlorophyll binding
H5J25_RS01080	COG1253	flavin adenine dinucleotide binding
H5J25_RS01085	COG0052	Belongs to the universal ribosomal protein uS2 family
H5J25_RS01090	COG0151	Belongs to the GarS family
H5J25_RS01105	COG0739	heme binding
H5J25_RS01110	COG4771	TonB-dependent receptor
H5J25_RS01115	COG0542	response to heat
H5J25_RS01130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5J25_RS01135	COG1845	cytochrome c oxidase, subunit III
H5J25_RS01140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5J25_RS01145	COG4771	TonB-dependent receptor
H5J25_RS01150	COG0673	inositol 2-dehydrogenase activity
H5J25_RS01155	COG0667	Aldo Keto reductase
H5J25_RS01165	COG0431	NADPH-dependent FMN reductase
H5J25_RS01190	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5J25_RS01205	COG0583	DNA-binding transcription factor activity
H5J25_RS01210	COG2814	Major facilitator Superfamily
H5J25_RS01235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H5J25_RS01240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H5J25_RS01250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5J25_RS01275	COG0501	Belongs to the peptidase M48B family
H5J25_RS01305	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS01320	COG0280	phosphate acetyltransferase
H5J25_RS01320	COG0281	malic enzyme
H5J25_RS01345	COG4771	TonB-dependent receptor
H5J25_RS01350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H5J25_RS01365	COG1619	proteins homologs of microcin C7 resistance protein MccF
H5J25_RS01370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5J25_RS01385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5J25_RS01405	COG4152	abc transporter atp-binding protein
H5J25_RS01410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5J25_RS01535	COG2885	chlorophyll binding
H5J25_RS01535	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5J25_RS01540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H5J25_RS01545	COG0354	folic acid binding
H5J25_RS01615	COG1012	belongs to the aldehyde dehydrogenase family
H5J25_RS01630	COG0784	Response regulator, receiver
H5J25_RS01630	COG2198	Histidine kinase
H5J25_RS01630	COG2205	protein histidine kinase activity
H5J25_RS01645	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5J25_RS01675	COG2205	protein histidine kinase activity
H5J25_RS01680	COG0745	RESPONSE REGULATOR receiver
H5J25_RS01685	COG1234	tRNA 3'-trailer cleavage
H5J25_RS01700	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS01710	COG0583	DNA-binding transcription factor activity
H5J25_RS01720	COG1942	4-Oxalocrotonate Tautomerase
H5J25_RS01725	COG1309	transcriptional regulator
H5J25_RS01780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5J25_RS01790	COG4191	Histidine kinase
H5J25_RS01790	COG0784	Response regulator, receiver
H5J25_RS01895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5J25_RS01905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5J25_RS01915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5J25_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS01935	COG1312	Catalyzes the dehydration of D-mannonate
H5J25_RS01945	COG2814	Major facilitator Superfamily
H5J25_RS01995	COG0667	Aldo Keto reductase
H5J25_RS02005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5J25_RS02010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5J25_RS02045	COG4774	siderophore transport
H5J25_RS02050	COG1309	transcriptional regulator
H5J25_RS02065	COG2723	6-phospho-beta-galactosidase activity
H5J25_RS02095	COG2814	Major facilitator Superfamily
H5J25_RS02110	COG4974	Belongs to the 'phage' integrase family
H5J25_RS02115	COG0517	IMP dehydrogenase activity
H5J25_RS02120	COG2814	Major facilitator Superfamily
H5J25_RS02125	COG1309	transcriptional regulator
H5J25_RS02145	COG0653	protein targeting
H5J25_RS02175	COG4771	TonB-dependent receptor
H5J25_RS02195	COG1621	beta-fructofuranosidase activity
H5J25_RS02200	COG3842	ATPase activity
H5J25_RS02205	COG0395	ABC-type sugar transport system, permease component
H5J25_RS02210	COG1175	transmembrane transport
H5J25_RS02215	COG1940	carbohydrate kinase activity
H5J25_RS02225	COG1609	Transcriptional regulator
H5J25_RS02245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5J25_RS02245	COG3153	acetyltransferase
H5J25_RS02250	COG1162	GTPase activity
H5J25_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
H5J25_RS02310	COG0318	PFAM AMP-dependent synthetase and ligase
H5J25_RS02315	COG4771	TonB-dependent receptor
H5J25_RS02330	COG0673	inositol 2-dehydrogenase activity
H5J25_RS02335	COG0300	oxidoreductase activity
H5J25_RS02355	COG1024	Enoyl-CoA hydratase
H5J25_RS02360	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS02370	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5J25_RS02380	COG2030	dehydratase
H5J25_RS02395	COG1024	Enoyl-CoA hydratase
H5J25_RS02405	COG1024	Enoyl-CoA hydratase
H5J25_RS02410	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS02430	COG2301	Belongs to the HpcH HpaI aldolase family
H5J25_RS02440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5J25_RS02450	COG3246	L-lysine catabolic process to acetate
H5J25_RS02465	COG3088	subunit of a heme lyase
H5J25_RS02505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5J25_RS02525	COG4235	cytochrome complex assembly
H5J25_RS02565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5J25_RS02570	COG2223	nitrite transmembrane transporter activity
H5J25_RS02585	COG0243	molybdopterin cofactor binding
H5J25_RS02590	COG1648	precorrin-2 dehydrogenase activity
H5J25_RS02590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5J25_RS02595	COG2814	Major facilitator Superfamily
H5J25_RS02610	COG0583	DNA-binding transcription factor activity
H5J25_RS02615	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H5J25_RS02630	COG2188	Transcriptional regulator
H5J25_RS02635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5J25_RS02640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5J25_RS02645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H5J25_RS02650	COG2971	BadF BadG BcrA BcrD
H5J25_RS02660	COG4948	Mandelate Racemase Muconate Lactonizing
H5J25_RS02665	COG1301	dicarboxylic acid transport
H5J25_RS02680	COG2989	Protein conserved in bacteria
H5J25_RS02690	COG3685	Protein conserved in bacteria
H5J25_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS02720	COG0667	Aldo Keto reductase
H5J25_RS02735	COG4191	Histidine kinase
H5J25_RS02735	COG0784	Response regulator, receiver
H5J25_RS02805	COG1131	(ABC) transporter
H5J25_RS02815	COG2272	Belongs to the type-B carboxylesterase lipase family
H5J25_RS02820	COG0583	DNA-binding transcription factor activity
H5J25_RS02825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5J25_RS02835	COG4771	TonB-dependent receptor
H5J25_RS02840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5J25_RS02850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5J25_RS02870	COG1473	amidohydrolase
H5J25_RS02915	COG1566	PFAM secretion protein HlyD family protein
H5J25_RS02935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5J25_RS02940	COG1741	Belongs to the pirin family
H5J25_RS02945	COG0583	DNA-binding transcription factor activity
H5J25_RS03050	COG2197	response regulator
H5J25_RS03065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H5J25_RS03075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5J25_RS03085	COG0424	maF-like protein
H5J25_RS03090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5J25_RS03105	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H5J25_RS03110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5J25_RS03130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5J25_RS03135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5J25_RS03140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5J25_RS03155	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H5J25_RS03175	COG0583	DNA-binding transcription factor activity
H5J25_RS03180	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS03195	COG2030	dehydratase
H5J25_RS03215	COG2733	membrane
H5J25_RS03225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5J25_RS03230	COG1127	ABC transporter
H5J25_RS03260	COG1959	2 iron, 2 sulfur cluster binding
H5J25_RS03265	COG0077	Prephenate dehydratase
H5J25_RS03270	COG3474	cytochrome
H5J25_RS03275	COG1611	Belongs to the LOG family
H5J25_RS03290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5J25_RS03305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5J25_RS03315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5J25_RS03325	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5J25_RS03330	COG1295	ribonuclease BN
H5J25_RS03335	COG0484	heat shock protein binding
H5J25_RS03350	COG0259	pyridoxamine-phosphate oxidase activity
H5J25_RS03365	COG0482	sulfurtransferase activity
H5J25_RS03385	COG2968	Membrane
H5J25_RS03390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5J25_RS03400	COG1970	mechanosensitive ion channel activity
H5J25_RS03440	COG0142	geranyltranstransferase activity
H5J25_RS03445	COG1605	Chorismate mutase
H5J25_RS03445	COG0287	Prephenate dehydrogenase
H5J25_RS03465	COG1185	polyribonucleotide nucleotidyltransferase activity
H5J25_RS03470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5J25_RS03475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5J25_RS03480	COG1435	thymidine kinase activity
H5J25_RS03495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H5J25_RS03500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H5J25_RS03520	COG0779	Required for maturation of 30S ribosomal subunits
H5J25_RS03525	COG2133	pyrroloquinoline quinone binding
H5J25_RS03560	COG1136	(ABC) transporter
H5J25_RS03560	COG0577	efflux transmembrane transporter activity
H5J25_RS03575	COG3608	succinylglutamate desuccinylase aspartoacylase
H5J25_RS03575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H5J25_RS03580	COG0584	glycerophosphoryl diester phosphodiesterase
H5J25_RS03595	COG3186	Phenylalanine-4-hydroxylase
H5J25_RS03600	COG2161	toxin-antitoxin pair type II binding
H5J25_RS03605	COG4115	mRNA cleavage
H5J25_RS03610	COG2264	protein methyltransferase activity
H5J25_RS03615	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS03660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5J25_RS03670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5J25_RS03675	COG0039	L-malate dehydrogenase activity
H5J25_RS03680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H5J25_RS03690	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5J25_RS03695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5J25_RS03740	COG1609	Transcriptional regulator
H5J25_RS03760	COG1082	Xylose isomerase domain protein TIM barrel
H5J25_RS03770	COG0517	IMP dehydrogenase activity
H5J25_RS03775	COG4974	Belongs to the 'phage' integrase family
H5J25_RS03780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5J25_RS03800	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5J25_RS03800	COG0596	Alpha beta hydrolase
H5J25_RS03815	COG1230	cation diffusion facilitator family transporter
H5J25_RS03910	COG0517	IMP dehydrogenase activity
H5J25_RS03915	COG4974	Belongs to the 'phage' integrase family
H5J25_RS03935	COG0628	permease
H5J25_RS03945	COG3239	Fatty acid desaturase
H5J25_RS03965	COG1917	Cupin 2, conserved barrel domain protein
H5J25_RS03970	COG0517	IMP dehydrogenase activity
H5J25_RS03975	COG4974	Belongs to the 'phage' integrase family
H5J25_RS04050	COG4974	Belongs to the 'phage' integrase family
H5J25_RS04075	COG2851	Citrate transporter
H5J25_RS04110	COG2197	response regulator
H5J25_RS04120	COG2885	chlorophyll binding
H5J25_RS04130	COG0668	transmembrane transport
H5J25_RS04175	COG3706	GGDEF domain
H5J25_RS04185	COG4191	Histidine kinase
H5J25_RS04190	COG3920	Histidine kinase
H5J25_RS04210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5J25_RS04225	COG0251	oxidation-reduction process
H5J25_RS04230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5J25_RS04240	COG1522	sequence-specific DNA binding
H5J25_RS04290	COG0626	cystathionine gamma-synthase activity
H5J25_RS04295	COG1573	uracil-dna glycosylase
H5J25_RS04315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5J25_RS04315	COG1017	nitric oxide dioxygenase activity
H5J25_RS04330	COG1959	2 iron, 2 sulfur cluster binding
H5J25_RS04345	COG0288	reversible hydration of carbon dioxide
H5J25_RS04360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5J25_RS04380	COG2351	hydroxyisourate hydrolase activity
H5J25_RS04455	COG1793	dna ligase
H5J25_RS04495	COG0596	Alpha beta hydrolase
H5J25_RS04530	COG0776	regulation of translation
H5J25_RS04625	COG0501	Belongs to the peptidase M48B family
H5J25_RS04630	COG1704	LemA family
H5J25_RS04645	COG0667	Aldo Keto reductase
H5J25_RS04650	COG0583	DNA-binding transcription factor activity
H5J25_RS04655	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS04665	COG0583	DNA-binding transcription factor activity
H5J25_RS04670	COG0583	DNA-binding transcription factor activity
H5J25_RS04675	COG4948	Mandelate Racemase Muconate Lactonizing
H5J25_RS04690	COG3685	Protein conserved in bacteria
H5J25_RS04705	COG0432	Pfam Uncharacterised protein family UPF0047
H5J25_RS04715	COG4221	oxidoreductase activity
H5J25_RS04730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5J25_RS04735	COG0746	molybdenum cofactor guanylyltransferase activity
H5J25_RS04740	COG0303	'Molybdopterin
H5J25_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS04765	COG2204	response regulator
H5J25_RS04825	COG0438	transferase activity, transferring glycosyl groups
H5J25_RS04845	COG1045	serine acetyltransferase
H5J25_RS04905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5J25_RS04910	COG2274	protein secretion by the type I secretion system
H5J25_RS04935	COG0667	Aldo Keto reductase
H5J25_RS04940	COG0640	Transcriptional regulator
H5J25_RS04950	COG0477	Major facilitator Superfamily
H5J25_RS04955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5J25_RS04960	COG4206	TonB-dependent receptor
H5J25_RS04975	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H5J25_RS05010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5J25_RS05030	COG1372	Participates in initiation and elongation during chromosome replication
H5J25_RS05030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5J25_RS05060	COG5001	Diguanylate cyclase
H5J25_RS05060	COG3300	MHYT domain
H5J25_RS05065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H5J25_RS05065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H5J25_RS05075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5J25_RS05085	COG1420	regulation of RNA biosynthetic process
H5J25_RS05090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H5J25_RS05100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5J25_RS05125	COG0484	heat shock protein binding
H5J25_RS05135	COG2003	Belongs to the UPF0758 family
H5J25_RS05160	COG0356	it plays a direct role in the translocation of protons across the membrane
H5J25_RS05165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5J25_RS05170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H5J25_RS05175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H5J25_RS05185	COG0322	excinuclease ABC activity
H5J25_RS05210	COG1381	Involved in DNA repair and RecF pathway recombination
H5J25_RS05215	COG0473	3-isopropylmalate dehydrogenase activity
H5J25_RS05235	COG2967	ApaG domain
H5J25_RS05240	COG0583	DNA-binding transcription factor activity
H5J25_RS05260	COG0187	DNA topoisomerase II activity
H5J25_RS05275	COG0842	Transport permease protein
H5J25_RS05280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5J25_RS05285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5J25_RS05300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5J25_RS05305	COG0602	queuosine metabolic process
H5J25_RS05320	COG0321	lipoyl(octanoyl) transferase activity
H5J25_RS05355	COG0723	plastoquinol--plastocyanin reductase activity
H5J25_RS05375	COG2030	dehydratase
H5J25_RS05375	COG1012	belongs to the aldehyde dehydrogenase family
H5J25_RS05400	COG0012	GTP binding
H5J25_RS05430	COG0193	aminoacyl-tRNA hydrolase activity
H5J25_RS05435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H5J25_RS05460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5J25_RS05460	COG0574	Belongs to the PEP-utilizing enzyme family
H5J25_RS05490	COG4964	Belongs to the GSP D family
H5J25_RS05515	COG0328	RNA-DNA hybrid ribonuclease activity
H5J25_RS05520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5J25_RS05525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5J25_RS05540	COG0509	glycine decarboxylation via glycine cleavage system
H5J25_RS05545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5J25_RS05590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5J25_RS05600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5J25_RS05610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5J25_RS05615	COG0154	amidase activity
H5J25_RS05620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5J25_RS05650	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5J25_RS05660	COG0740	serine-type endopeptidase activity
H5J25_RS05665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5J25_RS05670	COG0387	Pfam Sodium calcium exchanger
H5J25_RS05690	COG0776	regulation of translation
H5J25_RS05710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5J25_RS05740	COG2165	general secretion pathway protein
H5J25_RS05795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5J25_RS05800	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H5J25_RS05805	COG1138	Cytochrome C-type biogenesis protein
H5J25_RS05810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5J25_RS05815	COG3088	subunit of a heme lyase
H5J25_RS05830	COG0686	Belongs to the AlaDH PNT family
H5J25_RS05835	COG1522	sequence-specific DNA binding
H5J25_RS05855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5J25_RS05860	COG0492	ferredoxin-NADP+ reductase activity
H5J25_RS05895	COG3206	protein involved in exopolysaccharide biosynthesis
H5J25_RS05895	COG0489	protein tyrosine kinase activity
H5J25_RS05910	COG3409	Peptidoglycan-binding domain 1 protein
H5J25_RS05910	COG3267	Type II secretory pathway component ExeA
H5J25_RS05965	COG1054	Belongs to the UPF0176 family
H5J25_RS05975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H5J25_RS05980	COG0049	tRNA binding
H5J25_RS05985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5J25_RS05990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5J25_RS05995	COG0051	transcription antitermination factor activity, RNA binding
H5J25_RS06000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5J25_RS06005	COG0088	Forms part of the polypeptide exit tunnel
H5J25_RS06010	COG0089	rRNA binding
H5J25_RS06015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H5J25_RS06020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5J25_RS06025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H5J25_RS06030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5J25_RS06035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H5J25_RS06040	COG0255	Belongs to the universal ribosomal protein uL29 family
H5J25_RS06045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5J25_RS06050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H5J25_RS06055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5J25_RS06060	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5J25_RS06065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5J25_RS06070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5J25_RS06075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5J25_RS06080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H5J25_RS06085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H5J25_RS06090	COG1841	ribosomal large subunit assembly
H5J25_RS06095	COG0200	Binds to the 23S rRNA
H5J25_RS06100	COG0201	protein transport
H5J25_RS06105	COG0563	adenylate kinase activity
H5J25_RS06110	COG0745	RESPONSE REGULATOR receiver
H5J25_RS06115	COG2205	protein histidine kinase activity
H5J25_RS06130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H5J25_RS06135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H5J25_RS06140	COG0202	RNA polymerase activity
H5J25_RS06145	COG0203	ribosomal protein L17
H5J25_RS06150	COG1505	serine-type exopeptidase activity
H5J25_RS06155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5J25_RS06155	COG0519	Catalyzes the synthesis of GMP from XMP
H5J25_RS06165	COG1393	Belongs to the ArsC family
H5J25_RS06180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5J25_RS06195	COG1160	GTP binding
H5J25_RS06220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5J25_RS06230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5J25_RS06245	COG0511	ligase activity, forming carbon-carbon bonds
H5J25_RS06250	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5J25_RS06255	COG2022	thiamine diphosphate biosynthetic process
H5J25_RS06270	COG4251	negative regulation of phosphorylation
H5J25_RS06275	COG2066	Belongs to the glutaminase family
H5J25_RS06280	COG1045	serine acetyltransferase
H5J25_RS06285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H5J25_RS06310	COG0513	Belongs to the DEAD box helicase family
H5J25_RS06350	COG1192	Involved in chromosome partitioning
H5J25_RS06365	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H5J25_RS06375	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5J25_RS06380	COG2003	Belongs to the UPF0758 family
H5J25_RS06385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H5J25_RS06405	COG4221	oxidoreductase activity
H5J25_RS06425	COG0196	riboflavin kinase activity
H5J25_RS06430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5J25_RS06435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H5J25_RS06455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5J25_RS06460	COG0438	transferase activity, transferring glycosyl groups
H5J25_RS06470	COG1297	OPT oligopeptide transporter protein
H5J25_RS06475	COG1473	amidohydrolase
H5J25_RS06480	COG0433	COG0433 Predicted ATPase
H5J25_RS06490	COG0330	HflC and HflK could
H5J25_RS06495	COG0330	HflC and HflK could
H5J25_RS06500	COG0489	protein tyrosine kinase activity
H5J25_RS06505	COG1832	CoA-binding protein
H5J25_RS06530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5J25_RS06535	COG0739	heme binding
H5J25_RS06540	COG0316	Belongs to the HesB IscA family
H5J25_RS06560	COG0456	acetyltransferase
H5J25_RS06600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5J25_RS06605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5J25_RS06610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H5J25_RS06630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H5J25_RS06635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5J25_RS06660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5J25_RS06680	COG0047	phosphoribosylformylglycinamidine synthase activity
H5J25_RS06685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5J25_RS06690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5J25_RS06725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5J25_RS06745	COG0596	Alpha beta hydrolase
H5J25_RS06760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5J25_RS06785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H5J25_RS06790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5J25_RS06795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5J25_RS06800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5J25_RS06805	COG0805	protein transport
H5J25_RS06835	COG0784	Response regulator, receiver
H5J25_RS06855	COG2814	Major facilitator Superfamily
H5J25_RS06875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5J25_RS06880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5J25_RS06885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H5J25_RS06890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H5J25_RS06895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5J25_RS06910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5J25_RS06910	COG2169	Transcriptional regulator
H5J25_RS06925	COG5002	protein histidine kinase activity
H5J25_RS06925	COG5001	Diguanylate cyclase
H5J25_RS06925	COG3447	MASE1 domain protein
H5J25_RS06940	COG0586	Pfam SNARE associated Golgi protein
H5J25_RS06945	COG0189	ligase activity
H5J25_RS06950	COG0792	nuclease activity
H5J25_RS06955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H5J25_RS06965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5J25_RS06990	COG0477	Major facilitator Superfamily
H5J25_RS07005	COG0154	amidase activity
H5J25_RS07025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5J25_RS07030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5J25_RS07035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5J25_RS07055	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5J25_RS07060	COG1253	flavin adenine dinucleotide binding
H5J25_RS07065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H5J25_RS07070	COG1702	phosphate starvation-inducible protein PhoH
H5J25_RS07075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5J25_RS07090	COG4957	zinc ion binding
H5J25_RS07110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5J25_RS07120	COG0612	Peptidase, M16
H5J25_RS07130	COG1022	Amp-dependent synthetase and ligase
H5J25_RS07135	COG0405	Gamma-glutamyltransferase
H5J25_RS07155	COG0719	Fe-S assembly protein
H5J25_RS07165	COG0396	ATPase activity
H5J25_RS07170	COG0719	Fe-S assembly protein
H5J25_RS07180	COG2151	metal-sulfur cluster biosynthetic enzyme
H5J25_RS07185	COG0316	Belongs to the HesB IscA family
H5J25_RS07235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5J25_RS07245	COG0314	molybdopterin synthase activity
H5J25_RS07250	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H5J25_RS07255	COG0583	DNA-binding transcription factor activity
H5J25_RS07260	COG0450	alkyl hydroperoxide reductase
H5J25_RS07270	COG0730	response to heat
H5J25_RS07275	COG1045	serine acetyltransferase
H5J25_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS07305	COG0745	RESPONSE REGULATOR receiver
H5J25_RS07310	COG0704	Plays a role in the regulation of phosphate uptake
H5J25_RS07315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5J25_RS07325	COG0573	inorganic phosphate transmembrane transporter activity
H5J25_RS07340	COG5002	protein histidine kinase activity
H5J25_RS07375	COG0546	phosphoglycolate phosphatase activity
H5J25_RS07380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5J25_RS07385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5J25_RS07395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5J25_RS07400	COG0484	heat shock protein binding
H5J25_RS07405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5J25_RS07435	COG0438	transferase activity, transferring glycosyl groups
H5J25_RS07445	COG1215	transferase activity, transferring glycosyl groups
H5J25_RS07465	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H5J25_RS07480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5J25_RS07520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5J25_RS07550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5J25_RS07560	COG0745	RESPONSE REGULATOR receiver
H5J25_RS07575	COG3201	nicotinamide mononucleotide transporter
H5J25_RS07605	COG0481	GTPase activity
H5J25_RS07615	COG4149	molybdate abc transporter
H5J25_RS07625	COG4771	TonB-dependent receptor
H5J25_RS07630	COG0215	cysteine-tRNA ligase activity
H5J25_RS07635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5J25_RS07655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H5J25_RS07660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H5J25_RS07675	COG0756	dUTP diphosphatase activity
H5J25_RS07690	COG0028	Belongs to the TPP enzyme family
H5J25_RS07695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5J25_RS07715	COG0066	3-isopropylmalate dehydratase activity
H5J25_RS07720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5J25_RS07755	COG3682	Transcriptional regulator
H5J25_RS07775	COG2205	protein histidine kinase activity
H5J25_RS07785	COG0372	Belongs to the citrate synthase family
H5J25_RS07790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5J25_RS07795	COG2333	competence protein COMEC
H5J25_RS07795	COG0658	competence protein
H5J25_RS07800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5J25_RS07805	COG0303	'Molybdopterin
H5J25_RS07810	COG4771	TonB-dependent receptor
H5J25_RS07820	COG0134	indole-3-glycerol-phosphate synthase activity
H5J25_RS07825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5J25_RS07850	COG0149	triose-phosphate isomerase activity
H5J25_RS07855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5J25_RS07860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5J25_RS07865	COG3665	Urea carboxylase-associated protein
H5J25_RS07875	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H5J25_RS07895	COG0729	surface antigen
H5J25_RS07905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5J25_RS07920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H5J25_RS07925	COG0706	membrane insertase activity
H5J25_RS07935	COG0594	ribonuclease P activity
H5J25_RS07940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H5J25_RS07995	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS08000	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS08005	COG4771	TonB-dependent receptor
H5J25_RS08010	COG2814	Major facilitator Superfamily
H5J25_RS08025	COG3268	Saccharopine dehydrogenase
H5J25_RS08030	COG1132	(ABC) transporter
H5J25_RS08045	COG0183	Belongs to the thiolase family
H5J25_RS08055	COG0668	transmembrane transport
H5J25_RS08065	COG0693	protein deglycase activity
H5J25_RS08120	COG0729	surface antigen
H5J25_RS08140	COG3483	tryptophan 2,3-dioxygenase activity
H5J25_RS08160	COG0174	glutamine synthetase
H5J25_RS08165	COG0347	Belongs to the P(II) protein family
H5J25_RS08170	COG0024	Methionine aminopeptidase
H5J25_RS08175	COG1058	Belongs to the CinA family
H5J25_RS08175	COG1546	Belongs to the CinA family
H5J25_RS08185	COG1846	Transcriptional regulator
H5J25_RS08195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5J25_RS08210	COG2814	Major facilitator Superfamily
H5J25_RS08215	COG1566	PFAM secretion protein HlyD family protein
H5J25_RS08225	COG4774	siderophore transport
H5J25_RS08230	COG3128	pkhd-type hydroxylase
H5J25_RS08240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5J25_RS08250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5J25_RS08255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5J25_RS08260	COG1612	heme a metabolic process
H5J25_RS08275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5J25_RS08285	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H5J25_RS08300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H5J25_RS08305	COG1846	Transcriptional regulator
H5J25_RS08330	COG0463	Glycosyl transferase, family 2
H5J25_RS08340	COG1595	DNA-templated transcription, initiation
H5J25_RS08375	COG0531	amino acid
H5J25_RS08385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5J25_RS08415	COG0183	Belongs to the thiolase family
H5J25_RS08420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H5J25_RS08435	COG1012	belongs to the aldehyde dehydrogenase family
H5J25_RS08445	COG3876	Protein conserved in bacteria
H5J25_RS08470	COG1522	sequence-specific DNA binding
H5J25_RS08510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5J25_RS08520	COG2827	Endonuclease containing a URI domain
H5J25_RS08545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5J25_RS08580	COG0148	phosphopyruvate hydratase activity
H5J25_RS08595	COG2814	Major facilitator Superfamily
H5J25_RS08645	COG0210	DNA helicase
H5J25_RS08665	COG0306	phosphate transporter
H5J25_RS08670	COG0477	Major facilitator Superfamily
H5J25_RS08675	COG0742	ribosomal rna small subunit methyltransferase
H5J25_RS08705	COG2852	Protein conserved in bacteria
H5J25_RS08710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5J25_RS08715	COG0159	tryptophan synthase activity
H5J25_RS08725	COG0133	tryptophan synthase activity
H5J25_RS08730	COG0135	phosphoribosylanthranilate isomerase activity
H5J25_RS08735	COG0284	orotidine-5'-phosphate decarboxylase activity
H5J25_RS08790	COG0438	transferase activity, transferring glycosyl groups
H5J25_RS08795	COG0625	glutathione transferase activity
H5J25_RS08825	COG2363	Small membrane protein
H5J25_RS08835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5J25_RS08875	COG0494	nUDIX hydrolase
H5J25_RS08890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5J25_RS08915	COG0525	valine-tRNA ligase activity
H5J25_RS08920	COG0534	Mate efflux family protein
H5J25_RS08925	COG1597	lipid kinase activity
H5J25_RS08935	COG0113	porphobilinogen synthase activity
H5J25_RS08965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5J25_RS08985	COG0386	Belongs to the glutathione peroxidase family
H5J25_RS09010	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5J25_RS09025	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H5J25_RS09025	COG0644	oxidoreductase
H5J25_RS09035	COG0129	dihydroxy-acid dehydratase activity
H5J25_RS09045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5J25_RS09045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5J25_RS09050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5J25_RS09055	COG0101	tRNA pseudouridine synthase activity
H5J25_RS09060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5J25_RS09065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5J25_RS09070	COG0242	peptide deformylase activity
H5J25_RS09075	COG3590	peptidase
H5J25_RS09085	COG0784	Response regulator, receiver
H5J25_RS09090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5J25_RS09100	COG1301	dicarboxylic acid transport
H5J25_RS09105	COG0006	proline dipeptidase activity
H5J25_RS09115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5J25_RS09125	COG0538	isocitrate dehydrogenase activity
H5J25_RS09130	COG0688	phosphatidylethanolamine metabolic process
H5J25_RS09150	COG0528	UMP kinase activity
H5J25_RS09155	COG0233	cytoplasmic translational termination
H5J25_RS09170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H5J25_RS09175	COG0750	zinc metalloprotease
H5J25_RS09190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5J25_RS09195	COG0254	rRNA binding
H5J25_RS09235	COG2951	lytic endotransglycosylase activity
H5J25_RS09240	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5J25_RS09245	COG1686	Belongs to the peptidase S11 family
H5J25_RS09250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5J25_RS09265	COG0084	hydrolase, TatD family'
H5J25_RS09270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H5J25_RS09270	COG0321	lipoyl(octanoyl) transferase activity
H5J25_RS09280	COG3956	TIGRFAM MazG family protein
H5J25_RS09285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5J25_RS09295	COG2204	response regulator
H5J25_RS09310	COG3852	Histidine kinase
H5J25_RS09320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H5J25_RS09320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5J25_RS09330	COG1058	Belongs to the CinA family
H5J25_RS09330	COG1546	Belongs to the CinA family
H5J25_RS09335	COG2867	negative regulation of translational initiation
H5J25_RS09340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5J25_RS09345	COG0288	reversible hydration of carbon dioxide
H5J25_RS09355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H5J25_RS09360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H5J25_RS09375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H5J25_RS09390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5J25_RS09395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5J25_RS09415	COG0105	UTP biosynthetic process
H5J25_RS09425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5J25_RS09435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5J25_RS09440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5J25_RS09445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5J25_RS09460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5J25_RS09470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5J25_RS09475	COG0745	RESPONSE REGULATOR receiver
H5J25_RS09485	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H5J25_RS09490	COG1660	Displays ATPase and GTPase activities
H5J25_RS09495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5J25_RS09495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5J25_RS09500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5J25_RS09510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5J25_RS09515	COG1322	Protein conserved in bacteria
H5J25_RS09520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H5J25_RS09535	COG0840	transmembrane signaling receptor activity
H5J25_RS09540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5J25_RS09545	COG0741	lytic transglycosylase activity
H5J25_RS09555	COG2259	Doxx family
H5J25_RS09570	COG1254	Belongs to the acylphosphatase family
H5J25_RS09675	COG1392	Phosphate transport regulator
H5J25_RS09680	COG0306	phosphate transporter
H5J25_RS09710	COG2244	polysaccharide biosynthetic process
H5J25_RS09715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5J25_RS09720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5J25_RS09750	COG1522	sequence-specific DNA binding
H5J25_RS09760	COG3022	response to hydroperoxide
H5J25_RS09800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H5J25_RS09830	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5J25_RS09830	COG0022	dehydrogenase e1 component
H5J25_RS09835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5J25_RS09840	COG2814	Major facilitator Superfamily
H5J25_RS09880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5J25_RS09895	COG4221	oxidoreductase activity
H5J25_RS09905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5J25_RS09910	COG0415	Belongs to the DNA photolyase family
H5J25_RS09920	COG0123	including yeast histone deacetylase and acetoin utilization protein
H5J25_RS09925	COG0657	acetylesterase activity
H5J25_RS09930	COG1051	belongs to the nudix hydrolase family
H5J25_RS09950	COG3724	N-succinylarginine dihydrolase activity
H5J25_RS09960	COG0598	Magnesium transport protein CorA
H5J25_RS09965	COG4771	TonB-dependent receptor
H5J25_RS09970	COG0071	Belongs to the small heat shock protein (HSP20) family
H5J25_RS09975	COG0504	CTP synthase activity
H5J25_RS10000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5J25_RS10005	COG0363	glucosamine-6-phosphate deaminase activity
H5J25_RS10010	COG0129	dihydroxy-acid dehydratase activity
H5J25_RS10015	COG0837	glucose binding
H5J25_RS10020	COG0800	Aldolase
H5J25_RS10025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5J25_RS10030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5J25_RS10035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5J25_RS10050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5J25_RS10060	COG0360	Binds together with S18 to 16S ribosomal RNA
H5J25_RS10065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H5J25_RS10070	COG0359	binds to the 23S rRNA
H5J25_RS10105	COG0772	Belongs to the SEDS family
H5J25_RS10190	COG3949	Membrane
H5J25_RS10210	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H5J25_RS10230	COG4948	Mandelate Racemase Muconate Lactonizing
H5J25_RS10235	COG3104	oligopeptide transport
H5J25_RS10245	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H5J25_RS10255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5J25_RS10260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H5J25_RS10265	COG1522	sequence-specific DNA binding
H5J25_RS10285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5J25_RS10285	COG0517	IMP dehydrogenase activity
H5J25_RS10290	COG0473	3-isopropylmalate dehydrogenase activity
H5J25_RS10290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5J25_RS10310	COG0492	ferredoxin-NADP+ reductase activity
H5J25_RS10315	COG4566	intracellular signal transduction
H5J25_RS10320	COG2204	response regulator
H5J25_RS10330	COG2814	Major facilitator Superfamily
H5J25_RS10335	COG0583	DNA-binding transcription factor activity
H5J25_RS10390	COG1312	Catalyzes the dehydration of D-mannonate
H5J25_RS10400	COG3264	Mechanosensitive ion channel
H5J25_RS10400	COG1196	nuclear chromosome segregation
H5J25_RS10405	COG4191	Histidine kinase
H5J25_RS10405	COG0784	Response regulator, receiver
H5J25_RS10440	COG1609	Transcriptional regulator
H5J25_RS10445	COG0657	acetylesterase activity
H5J25_RS10455	COG0457	Tetratricopeptide repeat
H5J25_RS10475	COG0492	ferredoxin-NADP+ reductase activity
H5J25_RS10485	COG0628	permease
H5J25_RS10495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5J25_RS10500	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H5J25_RS10505	COG2080	2 iron, 2 sulfur cluster binding
H5J25_RS10510	COG1120	ATPase activity
H5J25_RS10515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5J25_RS10525	COG4206	TonB-dependent receptor
H5J25_RS10540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5J25_RS10565	COG2365	Tyrosine phosphatase family
H5J25_RS10590	COG1301	dicarboxylic acid transport
H5J25_RS10595	COG4191	Histidine kinase
H5J25_RS10600	COG2204	response regulator
H5J25_RS10605	COG0175	sulfate reduction
H5J25_RS10615	COG1218	3'(2'),5'-bisphosphate nucleotidase
H5J25_RS10625	COG2304	oxidoreductase activity
H5J25_RS10635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5J25_RS10660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5J25_RS10665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5J25_RS10680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H5J25_RS10685	COG1562	ergosterol biosynthetic process
H5J25_RS10690	COG1562	ergosterol biosynthetic process
H5J25_RS10700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5J25_RS10710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5J25_RS10720	COG3394	polysaccharide catabolic process
H5J25_RS10735	COG0488	(ABC) transporter
H5J25_RS10740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5J25_RS10750	COG2081	HI0933 family
H5J25_RS10760	COG1671	Belongs to the UPF0178 family
H5J25_RS10765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5J25_RS10770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5J25_RS10795	COG2226	methyltransferase
H5J25_RS10795	COG0596	Alpha beta hydrolase
H5J25_RS10795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5J25_RS10825	COG2124	cytochrome p450
H5J25_RS10825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5J25_RS10830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H5J25_RS10840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5J25_RS10855	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5J25_RS10865	COG2234	aminopeptidase activity
H5J25_RS10870	COG1956	GAF domain-containing protein
H5J25_RS10880	COG0564	pseudouridine synthase activity
H5J25_RS10890	COG0655	NAD(P)H dehydrogenase (quinone) activity
H5J25_RS10895	COG1741	Belongs to the pirin family
H5J25_RS10900	COG0583	DNA-binding transcription factor activity
H5J25_RS10915	COG1228	amidohydrolase
H5J25_RS10920	COG2084	Dehydrogenase
H5J25_RS10925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5J25_RS10945	COG2308	Evidence 4 Homologs of previously reported genes of
H5J25_RS10970	COG1410	methionine synthase
H5J25_RS10970	COG0646	methionine synthase
H5J25_RS11000	COG0667	Aldo Keto reductase
H5J25_RS11015	COG2311	Membrane
H5J25_RS11020	COG2818	Glycosylase
H5J25_RS11035	COG0335	large ribosomal subunit rRNA binding
H5J25_RS11055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5J25_RS11060	COG0228	four-way junction DNA binding
H5J25_RS11065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5J25_RS11070	COG5001	Diguanylate cyclase
H5J25_RS11070	COG3300	MHYT domain
H5J25_RS11075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5J25_RS11080	COG0552	protein localization to endoplasmic reticulum
H5J25_RS11085	COG2917	probably involved in intracellular septation
H5J25_RS11090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5J25_RS11095	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H5J25_RS11100	COG1842	Phage shock protein A
H5J25_RS11130	COG2166	iron-sulfur cluster assembly
H5J25_RS11145	COG0484	heat shock protein binding
H5J25_RS11155	COG3023	N-Acetylmuramoyl-L-alanine amidase
H5J25_RS11165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5J25_RS11170	COG2201	protein-glutamate methylesterase activity
H5J25_RS11200	COG0564	pseudouridine synthase activity
H5J25_RS11205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5J25_RS11220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5J25_RS11225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5J25_RS11260	COG3830	Belongs to the UPF0237 family
H5J25_RS11260	COG0560	Phosphoserine phosphatase
H5J25_RS11265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H5J25_RS11270	COG0028	Belongs to the TPP enzyme family
H5J25_RS11285	COG2353	YceI-like domain
H5J25_RS11310	COG0302	gtp cyclohydrolase
H5J25_RS11315	COG4771	TonB-dependent receptor
H5J25_RS11365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H5J25_RS11370	COG2226	methyltransferase
H5J25_RS11375	COG2205	protein histidine kinase activity
H5J25_RS11375	COG0784	Response regulator, receiver
H5J25_RS11375	COG2198	Histidine kinase
H5J25_RS11380	COG0784	Response regulator, receiver
H5J25_RS11380	COG2198	Histidine kinase
H5J25_RS11380	COG5002	protein histidine kinase activity
H5J25_RS11395	COG3300	MHYT domain
H5J25_RS11395	COG5001	Diguanylate cyclase
H5J25_RS11415	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H5J25_RS11435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5J25_RS11440	COG0268	Binds directly to 16S ribosomal RNA
H5J25_RS11445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5J25_RS11450	COG2226	methyltransferase
H5J25_RS11455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5J25_RS11485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5J25_RS11490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5J25_RS11495	COG0539	negative regulation of cytoplasmic translation
H5J25_RS11500	COG0776	regulation of translation
H5J25_RS11540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5J25_RS11580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H5J25_RS11590	COG1007	ATP synthesis coupled electron transport
H5J25_RS11605	COG0713	ATP synthesis coupled electron transport
H5J25_RS11615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5J25_RS11620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H5J25_RS11625	COG1034	ATP synthesis coupled electron transport
H5J25_RS11645	COG0649	NAD binding
H5J25_RS11650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5J25_RS11655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5J25_RS11660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5J25_RS11665	COG0483	inositol monophosphate 1-phosphatase activity
H5J25_RS11670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5J25_RS11675	COG0739	heme binding
H5J25_RS11680	COG1376	ErfK ybiS ycfS ynhG family protein
H5J25_RS11685	COG3108	Peptidase M15
H5J25_RS11690	COG0352	thiamine-phosphate diphosphorylase activity
H5J25_RS11695	COG1830	Aldolase
H5J25_RS11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5J25_RS11705	COG0126	phosphoglycerate kinase activity
H5J25_RS11715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5J25_RS11750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5J25_RS11760	COG0789	Transcriptional regulator
H5J25_RS11775	COG1024	Enoyl-CoA hydratase
H5J25_RS11775	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5J25_RS11780	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS11785	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS11790	COG1946	Acyl-CoA thioesterase
H5J25_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS11815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5J25_RS11840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5J25_RS11845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5J25_RS11855	COG3384	dioxygenase
H5J25_RS11875	COG0402	S-adenosylhomocysteine deaminase activity
H5J25_RS11885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5J25_RS11895	COG2351	hydroxyisourate hydrolase activity
H5J25_RS11900	COG2072	flavoprotein involved in K transport
H5J25_RS11920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5J25_RS11960	COG5001	Diguanylate cyclase
H5J25_RS12030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5J25_RS12050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5J25_RS12070	COG3706	GGDEF domain
H5J25_RS12070	COG5001	Diguanylate cyclase
H5J25_RS12070	COG4251	negative regulation of phosphorylation
H5J25_RS12070	COG2203	Gaf domain
H5J25_RS12075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5J25_RS12080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5J25_RS12110	COG0653	protein targeting
H5J25_RS12145	COG1074	ATP-dependent DNA helicase activity
H5J25_RS12155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5J25_RS12160	COG3178	'Phosphotransferase
H5J25_RS12165	COG0802	atpase or kinase
H5J25_RS12170	COG2205	protein histidine kinase activity
H5J25_RS12175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H5J25_RS12185	COG1678	Uncharacterized ACR, COG1678
H5J25_RS12240	COG0670	Belongs to the BI1 family
H5J25_RS12245	COG2032	superoxide dismutase activity
H5J25_RS12270	COG0300	oxidoreductase activity
H5J25_RS12280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5J25_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
H5J25_RS12295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5J25_RS12295	COG1648	precorrin-2 dehydrogenase activity
H5J25_RS12305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5J25_RS12315	COG0175	sulfate reduction
H5J25_RS12325	COG0305	Participates in initiation and elongation during chromosome replication
H5J25_RS12340	COG0840	transmembrane signaling receptor activity
H5J25_RS12345	COG5328	Belongs to the UPF0262 family
H5J25_RS12350	COG3757	hydrolase, family 25
H5J25_RS12355	COG0295	cytidine deaminase activity
H5J25_RS12370	COG0717	Belongs to the dCTP deaminase family
H5J25_RS12435	COG0617	tRNA 3'-terminal CCA addition
H5J25_RS12480	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS12485	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5J25_RS12490	COG2321	neutral zinc metallopeptidase
H5J25_RS12495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H5J25_RS12505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5J25_RS12510	COG0849	cell division
H5J25_RS12515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5J25_RS12520	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5J25_RS12525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5J25_RS12530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5J25_RS12535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5J25_RS12550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5J25_RS12555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5J25_RS12560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5J25_RS12575	COG0275	rRNA processing
H5J25_RS12580	COG2001	Belongs to the MraZ family
H5J25_RS12620	COG1192	Involved in chromosome partitioning
H5J25_RS12625	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5J25_RS12635	COG3761	NADH ubiquinone oxidoreductase 17.2 kD subunit
H5J25_RS12645	COG1278	Cold shock
H5J25_RS12660	COG3300	MHYT domain
H5J25_RS12660	COG5001	Diguanylate cyclase
H5J25_RS12670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5J25_RS12670	COG2755	lipolytic protein G-D-S-L family
H5J25_RS12680	COG0250	Participates in transcription elongation, termination and antitermination
H5J25_RS12700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5J25_RS12705	COG0081	regulation of translation
H5J25_RS12720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5J25_RS12725	COG0222	ribosome binding
H5J25_RS12740	COG3655	Transcriptional regulator
H5J25_RS12765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5J25_RS12775	COG0745	RESPONSE REGULATOR receiver
H5J25_RS12785	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H5J25_RS12820	COG2186	Transcriptional regulator
H5J25_RS12830	COG2755	lipolytic protein G-D-S-L family
H5J25_RS12835	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS12840	COG2271	Major facilitator Superfamily
H5J25_RS12895	COG2268	Band 7 protein
H5J25_RS12905	COG0604	alcohol dehydrogenase
H5J25_RS12920	COG3706	GGDEF domain
H5J25_RS12930	COG0318	PFAM AMP-dependent synthetase and ligase
H5J25_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
H5J25_RS12945	COG1722	exodeoxyribonuclease VII activity
H5J25_RS12955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5J25_RS12965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5J25_RS12970	COG4206	TonB-dependent receptor
H5J25_RS12990	COG0343	queuine tRNA-ribosyltransferase activity
H5J25_RS13010	COG1530	ribonuclease E activity
H5J25_RS13015	COG0501	Belongs to the peptidase M48B family
H5J25_RS13025	COG1131	(ABC) transporter
H5J25_RS13030	COG0842	Transport permease protein
H5J25_RS13040	COG1494	fructose-1,6-bisphosphatase
H5J25_RS13045	COG2171	N-acyltransferase activity
H5J25_RS13060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5J25_RS13065	COG0784	Response regulator, receiver
H5J25_RS13070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5J25_RS13120	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H5J25_RS13120	COG0662	Cupin 2, conserved barrel domain protein
H5J25_RS13125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5J25_RS13135	COG2204	response regulator
H5J25_RS13145	COG0187	DNA topoisomerase II activity
H5J25_RS13150	COG0488	(ABC) transporter
H5J25_RS13170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5J25_RS13175	COG0513	Belongs to the DEAD box helicase family
H5J25_RS13185	COG0183	Belongs to the thiolase family
H5J25_RS13200	COG4770	biotin carboxylase activity
H5J25_RS13210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5J25_RS13225	COG1024	Enoyl-CoA hydratase
H5J25_RS13230	COG0346	lactoylglutathione lyase activity
H5J25_RS13240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5J25_RS13250	COG3590	peptidase
H5J25_RS13260	COG3275	phosphorelay sensor kinase activity
H5J25_RS13265	COG3279	Response regulator of the LytR AlgR family
H5J25_RS13305	COG0312	modulator of DNA gyrase
H5J25_RS13345	COG2271	Major facilitator Superfamily
H5J25_RS13355	COG2721	sulfolactate sulfo-lyase activity
H5J25_RS13360	COG1609	Transcriptional regulator
H5J25_RS13365	COG1904	glucuronate isomerase
H5J25_RS13370	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H5J25_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS13385	COG2272	Belongs to the type-B carboxylesterase lipase family
H5J25_RS13485	COG0688	phosphatidylethanolamine metabolic process
H5J25_RS13570	COG5507	3-demethylubiquinone-9 3-methyltransferase
H5J25_RS13605	COG0494	nUDIX hydrolase
H5J25_RS13610	COG1741	Belongs to the pirin family
H5J25_RS13615	COG0596	Alpha beta hydrolase
H5J25_RS13630	COG2080	2 iron, 2 sulfur cluster binding
H5J25_RS13635	COG0243	molybdopterin cofactor binding
H5J25_RS13660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5J25_RS13665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5J25_RS13690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5J25_RS13810	COG0358	DNA primase activity
H5J25_RS14020	COG0582	viral genome integration into host DNA
H5J25_RS14030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5J25_RS14040	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H5J25_RS14050	COG1914	H( )-stimulated, divalent metal cation uptake system
H5J25_RS14070	COG2301	Belongs to the HpcH HpaI aldolase family
H5J25_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS14100	COG2272	Belongs to the type-B carboxylesterase lipase family
H5J25_RS14105	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5J25_RS14120	COG2814	Major facilitator Superfamily
H5J25_RS14145	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H5J25_RS14150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5J25_RS14160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H5J25_RS14170	COG0443	Heat shock 70 kDa protein
H5J25_RS14210	COG1196	nuclear chromosome segregation
H5J25_RS14240	COG0586	Pfam SNARE associated Golgi protein
H5J25_RS14265	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H5J25_RS14275	COG0793	Belongs to the peptidase S41A family
H5J25_RS14285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H5J25_RS14290	COG0799	negative regulation of ribosome biogenesis
H5J25_RS14295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H5J25_RS14310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5J25_RS14330	COG0037	tRNA processing
H5J25_RS14340	COG1426	Protein conserved in bacteria
H5J25_RS14350	COG2255	four-way junction helicase activity
H5J25_RS14365	COG0632	four-way junction helicase activity
H5J25_RS14370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5J25_RS14375	COG0217	transcriptional regulatory protein
H5J25_RS14385	COG3750	Belongs to the UPF0335 family
H5J25_RS14400	COG0469	pyruvate kinase activity
H5J25_RS14415	COG1011	Hydrolase
H5J25_RS14420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5J25_RS14435	COG0454	-acetyltransferase
H5J25_RS14440	COG0588	phosphoglycerate mutase activity
H5J25_RS14445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H5J25_RS14450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5J25_RS14465	COG3100	YcgL domain-containing protein
H5J25_RS14465	COG0561	phosphatase activity
H5J25_RS14485	COG1881	PFAM PEBP family protein
H5J25_RS14490	COG0753	catalase activity
H5J25_RS14540	COG0625	glutathione transferase activity
H5J25_RS14545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H5J25_RS14550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5J25_RS14580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H5J25_RS14585	COG0235	Class ii aldolase
H5J25_RS14615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5J25_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS14660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5J25_RS14670	COG0406	alpha-ribazole phosphatase activity
H5J25_RS14690	COG0673	inositol 2-dehydrogenase activity
H5J25_RS14715	COG0800	Aldolase
H5J25_RS14740	COG2186	Transcriptional regulator
H5J25_RS14780	COG3940	Belongs to the glycosyl hydrolase 43 family
H5J25_RS14785	COG3507	Belongs to the glycosyl hydrolase 43 family
H5J25_RS14800	COG0129	dihydroxy-acid dehydratase activity
H5J25_RS14815	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS14840	COG2706	6-phosphogluconolactonase activity
H5J25_RS14845	COG1063	alcohol dehydrogenase
H5J25_RS14850	COG4221	oxidoreductase activity
H5J25_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS14875	COG3920	Histidine kinase
H5J25_RS14915	COG1335	isochorismatase
H5J25_RS14920	COG3546	catalase activity
H5J25_RS14935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5J25_RS14960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5J25_RS14965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5J25_RS14965	COG2010	Cytochrome c
H5J25_RS14975	COG0243	molybdopterin cofactor binding
H5J25_RS14985	COG2354	Protein conserved in bacteria
H5J25_RS14990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5J25_RS15005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5J25_RS15010	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H5J25_RS15015	COG2080	2 iron, 2 sulfur cluster binding
H5J25_RS15020	COG0823	Involved in the tonB-independent uptake of proteins
H5J25_RS15025	COG0840	transmembrane signaling receptor activity
H5J25_RS15040	COG0784	Response regulator, receiver
H5J25_RS15040	COG4191	Histidine kinase
H5J25_RS15060	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS15065	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS15080	COG0612	Peptidase, M16
H5J25_RS15090	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
H5J25_RS15120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5J25_RS15125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5J25_RS15200	COG1024	Enoyl-CoA hydratase
H5J25_RS15210	COG1215	transferase activity, transferring glycosyl groups
H5J25_RS15230	COG2205	protein histidine kinase activity
H5J25_RS15240	COG4191	Histidine kinase
H5J25_RS15240	COG0784	Response regulator, receiver
H5J25_RS15275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5J25_RS15295	COG4771	TonB-dependent receptor
H5J25_RS15305	COG0288	reversible hydration of carbon dioxide
H5J25_RS15330	COG4191	Histidine kinase
H5J25_RS15335	COG3346	SURF1 family
H5J25_RS15340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5J25_RS15345	COG1845	cytochrome c oxidase, subunit III
H5J25_RS15350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5J25_RS15355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5J25_RS15360	COG0477	Major facilitator Superfamily
H5J25_RS15390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5J25_RS15395	COG4133	protoheme IX ABC transporter activity
H5J25_RS15405	COG2154	pterin-4-alpha-carbinolamine dehydratase
H5J25_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
H5J25_RS15435	COG1174	glycine betaine transport
H5J25_RS15445	COG1335	isochorismatase
H5J25_RS15450	COG0251	oxidation-reduction process
H5J25_RS15455	COG2267	carboxylic ester hydrolase activity
H5J25_RS15460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5J25_RS15545	COG4181	ATPase activity
H5J25_RS15570	COG0246	Mannitol dehydrogenase
H5J25_RS15585	COG1522	sequence-specific DNA binding
H5J25_RS15615	COG4206	TonB-dependent receptor
H5J25_RS15620	COG0436	Aminotransferase
H5J25_RS15630	COG0531	amino acid
H5J25_RS15645	COG0840	transmembrane signaling receptor activity
H5J25_RS15660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5J25_RS15685	COG4771	TonB-dependent receptor
H5J25_RS15740	COG2244	polysaccharide biosynthetic process
H5J25_RS15745	COG0517	IMP dehydrogenase activity
H5J25_RS15750	COG1733	regulation of RNA biosynthetic process
H5J25_RS15755	COG0702	epimerase
H5J25_RS15770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5J25_RS15790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5J25_RS15800	COG2076	Multidrug Resistance protein
H5J25_RS15825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5J25_RS15860	COG2885	chlorophyll binding
H5J25_RS15865	COG0823	Involved in the tonB-independent uptake of proteins
H5J25_RS15885	COG0824	Thioesterase
H5J25_RS15890	COG2070	2-Nitropropane dioxygenase
H5J25_RS15900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5J25_RS15925	COG0297	glycogen (starch) synthase activity
H5J25_RS15930	COG0625	glutathione transferase activity
H5J25_RS15935	COG0628	permease
H5J25_RS15940	COG0681	Belongs to the peptidase S26 family
H5J25_RS15945	COG0736	holo-[acyl-carrier-protein] synthase activity
H5J25_RS15950	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5J25_RS15955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5J25_RS15960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5J25_RS15960	COG1565	acr, cog1565
H5J25_RS15965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5J25_RS15970	COG0109	protoheme IX farnesyltransferase activity
H5J25_RS15980	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H5J25_RS16010	COG0183	Belongs to the thiolase family
H5J25_RS16015	COG0459	protein refolding
H5J25_RS16020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5J25_RS16025	COG0534	Mate efflux family protein
H5J25_RS16045	COG2860	membrane
H5J25_RS16050	COG1764	response to oxidative stress
H5J25_RS16065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5J25_RS16095	COG2226	methyltransferase
H5J25_RS16100	COG0194	GDP metabolic process
H5J25_RS16125	COG0131	Imidazoleglycerol-phosphate dehydratase
H5J25_RS16140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5J25_RS16145	COG0107	imidazoleglycerol-phosphate synthase activity
H5J25_RS16155	COG0140	phosphoribosyl-ATP diphosphatase activity
H5J25_RS16165	COG0531	amino acid
H5J25_RS16170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5J25_RS16180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H5J25_RS16240	COG2204	response regulator
H5J25_RS16260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5J25_RS16265	COG0351	phosphomethylpyrimidine kinase
H5J25_RS16265	COG0352	thiamine-phosphate diphosphorylase activity
H5J25_RS16270	COG3813	Protein conserved in bacteria
H5J25_RS16275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5J25_RS16280	COG1301	dicarboxylic acid transport
H5J25_RS16305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5J25_RS16320	COG2095	MarC family integral membrane protein
H5J25_RS16325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5J25_RS16330	COG1872	DUF167
H5J25_RS16340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5J25_RS16350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5J25_RS16430	COG1862	Preprotein translocase
H5J25_RS16440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5J25_RS16455	COG1482	cell wall glycoprotein biosynthetic process
H5J25_RS16460	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5J25_RS16470	COG1278	Cold shock
H5J25_RS16480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5J25_RS16495	COG0166	Belongs to the GPI family
H5J25_RS16500	COG0681	Belongs to the peptidase S26 family
H5J25_RS16505	COG0571	ribonuclease III activity
H5J25_RS16510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5J25_RS16515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5J25_RS16520	COG0659	secondary active sulfate transmembrane transporter activity
H5J25_RS16525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5J25_RS16530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5J25_RS16550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5J25_RS16595	COG0583	DNA-binding transcription factor activity
H5J25_RS16630	COG1024	Enoyl-CoA hydratase
H5J25_RS16635	COG1024	Enoyl-CoA hydratase
H5J25_RS16695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5J25_RS16715	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H5J25_RS16720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5J25_RS16725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5J25_RS16740	COG0484	heat shock protein binding
H5J25_RS16745	COG1192	Involved in chromosome partitioning
H5J25_RS16750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5J25_RS16760	COG1754	DNA topoisomerase type I activity
H5J25_RS16760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5J25_RS16765	COG3548	integral membrane protein
H5J25_RS16775	COG0758	DNA mediated transformation
H5J25_RS16780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H5J25_RS16785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5J25_RS16795	COG0156	8-amino-7-oxononanoate synthase activity
H5J25_RS16820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5J25_RS16840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5J25_RS16845	COG4786	Flagellar basal body rod
H5J25_RS16860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5J25_RS16875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5J25_RS16930	COG1677	Flagellar hook-basal body complex protein FliE
H5J25_RS16940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5J25_RS16990	COG1987	bacterial-type flagellum assembly
H5J25_RS17000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5J25_RS17025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5J25_RS17025	COG1648	precorrin-2 dehydrogenase activity
H5J25_RS17040	COG0165	Argininosuccinate lyase
H5J25_RS17050	COG5001	Diguanylate cyclase
H5J25_RS17075	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5J25_RS17085	COG1758	RNA polymerase activity
H5J25_RS17090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5J25_RS17105	COG0436	Aminotransferase
H5J25_RS17110	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5J25_RS17120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5J25_RS17130	COG1329	Transcriptional regulator
H5J25_RS17135	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5J25_RS17150	COG0739	heme binding
H5J25_RS17165	COG0730	response to heat
H5J25_RS17175	COG1215	transferase activity, transferring glycosyl groups
H5J25_RS17180	COG2373	Large extracellular alpha-helical protein
H5J25_RS17185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5J25_RS17190	COG0308	aminopeptidase N
H5J25_RS17200	COG0501	Belongs to the peptidase M48B family
H5J25_RS17220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5J25_RS17230	COG1960	acyl-CoA dehydrogenase activity
H5J25_RS17250	COG3104	oligopeptide transport
H5J25_RS17310	COG0783	Belongs to the Dps family
H5J25_RS17315	COG1408	metallophosphoesterase
H5J25_RS17320	COG1793	dna ligase
H5J25_RS17320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H5J25_RS17340	COG1278	Cold shock
H5J25_RS17345	COG0861	Integral membrane protein TerC family
H5J25_RS17365	COG1137	ATPase activity
H5J25_RS17390	COG1201	RNA secondary structure unwinding
H5J25_RS17425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5J25_RS17440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5J25_RS17445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5J25_RS17455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H5J25_RS17460	COG0416	fatty acid biosynthetic process
H5J25_RS17465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5J25_RS17475	COG0776	regulation of translation
H5J25_RS17490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5J25_RS17490	COG1199	ATP-dependent helicase activity
H5J25_RS17500	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H5J25_RS17510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5J25_RS17525	COG2086	electron transfer activity
H5J25_RS17530	COG0045	succinate-CoA ligase (ADP-forming) activity
H5J25_RS17550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5J25_RS17555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5J25_RS17570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5J25_RS17570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5J25_RS17580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H5J25_RS17600	COG1902	pentaerythritol trinitrate reductase activity
H5J25_RS17625	COG0629	single-stranded DNA binding
H5J25_RS17640	COG2813	Specifically methylates the guanine in position
H5J25_RS17640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5J25_RS17645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5J25_RS17650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5J25_RS17655	COG0287	Prephenate dehydrogenase
H5J25_RS17675	COG2884	Cell division ATP-binding protein ftsE
H5J25_RS17720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5J25_RS17730	COG2983	Belongs to the UPF0260 family
H5J25_RS17735	COG1999	signal sequence binding
H5J25_RS17765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5J25_RS17770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5J25_RS17775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5J25_RS17780	COG0237	dephospho-CoA kinase activity
H5J25_RS17785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5J25_RS17790	COG0424	maF-like protein
H5J25_RS17795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H5J25_RS17810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H5J25_RS17820	COG0861	Integral membrane protein TerC family
H5J25_RS17835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H5J25_RS17840	COG0445	tRNA wobble uridine modification
H5J25_RS17845	COG0357	Ribosomal RNA small subunit methyltransferase G
H5J25_RS17870	COG0495	leucyl-tRNA aminoacylation
H5J25_RS17885	COG0352	thiamine-phosphate diphosphorylase activity
H5J25_RS17895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5J25_RS17905	COG0708	Exodeoxyribonuclease III
H5J25_RS17915	COG1674	ftsk spoiiie
H5J25_RS17920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5J25_RS17965	COG0181	hydroxymethylbilane synthase activity
H5J25_RS17970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5J25_RS17975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5J25_RS17995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5J25_RS18005	COG0138	bifunctional purine biosynthesis protein purh
H5J25_RS18040	COG1131	(ABC) transporter
H5J25_RS18055	COG0312	modulator of DNA gyrase
H5J25_RS18070	COG0347	Belongs to the P(II) protein family
H5J25_RS18075	COG0004	ammonium transporteR
H5J25_RS18105	COG0514	ATP-dependent DNA helicase (RecQ)
H5J25_RS18125	COG0339	signal peptide processing
H5J25_RS18130	COG5265	(ABC) transporter
H5J25_RS18155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H5J25_RS18160	COG3038	cytochrome b561
H5J25_RS18170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H5J25_RS18180	COG1595	DNA-templated transcription, initiation
H5J25_RS18185	COG0698	ribose 5-phosphate isomerase
H5J25_RS18190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5J25_RS18200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5J25_RS18215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H5J25_RS18230	COG2957	Belongs to the agmatine deiminase family
H5J25_RS18235	COG0587	DNA-directed DNA polymerase activity
H5J25_RS18250	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H5J25_RS18255	COG1088	dTDP-glucose 4,6-dehydratase activity
H5J25_RS18265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H5J25_RS18280	COG1968	undecaprenyl-diphosphatase activity
H5J25_RS18310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5J25_RS18310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5J25_RS18335	COG1309	transcriptional regulator
H5J25_RS18345	COG2814	Major facilitator Superfamily
H5J25_RS18355	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5J25_RS18365	COG0072	phenylalanine-tRNA ligase activity
H5J25_RS18370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5J25_RS18380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H5J25_RS18385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5J25_RS18410	COG2824	Alkylphosphonate utilization operon protein PhnA
H5J25_RS18435	COG3609	addiction module antidote protein, CC2985 family
H5J25_RS18455	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H5J25_RS18510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5J25_RS18525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5J25_RS18530	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H5J25_RS18585	COG0671	phosphoesterase, PA-phosphatase related
H5J25_RS18595	COG4206	TonB-dependent receptor
H5J25_RS18635	COG2271	Major facilitator Superfamily
H5J25_RS18715	COG1196	nuclear chromosome segregation
H5J25_RS18715	COG0741	lytic transglycosylase activity
H5J25_RS18715	COG0739	heme binding
H5J25_RS18725	COG0587	DNA-directed DNA polymerase activity
H5J25_RS18750	COG0776	regulation of translation
H5J25_RS18840	COG0629	single-stranded DNA binding
H5J25_RS19055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5J25_RS19080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5J25_RS19095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5J25_RS19095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5J25_RS19105	COG0730	response to heat
H5J25_RS19110	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5J25_RS19120	COG2391	methyltransferase activity
H5J25_RS19135	COG0450	alkyl hydroperoxide reductase
H5J25_RS19160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5J25_RS19165	COG1742	UPF0060 membrane protein
H5J25_RS19170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5J25_RS19170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5J25_RS19225	COG1230	cation diffusion facilitator family transporter
H5J25_RS19275	COG2132	Multicopper oxidase
H5J25_RS19315	COG0789	Transcriptional regulator
H5J25_RS19320	COG0789	Transcriptional regulator
H5J25_RS19370	COG1677	Flagellar hook-basal body complex protein FliE
H5J25_RS19390	COG0492	ferredoxin-NADP+ reductase activity
H5J25_RS19430	COG0784	Response regulator, receiver
H5J25_RS19430	COG4191	Histidine kinase
H5J25_RS19470	COG0135	phosphoribosylanthranilate isomerase activity
H5J25_RS19485	COG1846	Transcriptional regulator
H5J25_RS19525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5J25_RS19540	COG0667	Aldo Keto reductase
H5J25_RS19645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5J25_RS19670	COG0210	DNA helicase
H5J25_RS19725	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H5J25_RS19730	COG2124	cytochrome p450
H5J25_RS19745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5J25_RS19750	COG0673	inositol 2-dehydrogenase activity
H5J25_RS19785	COG0784	Response regulator, receiver
H5J25_RS19785	COG4191	Histidine kinase
H5J25_RS19795	COG2172	sigma factor antagonist activity
H5J25_RS19800	COG1366	Belongs to the anti-sigma-factor antagonist family
H5J25_RS19805	COG1366	Belongs to the anti-sigma-factor antagonist family
H5J25_RS19810	COG4191	Histidine kinase
H5J25_RS19810	COG0784	Response regulator, receiver
H5J25_RS19835	COG1064	alcohol dehydrogenase
H5J25_RS19855	COG0693	protein deglycase activity
H5J25_RS20005	COG3736	Type IV secretory pathway, component VirB8
H5J25_RS20015	COG2948	multi-organism process
H5J25_RS20020	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
H5J25_RS20035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5J25_RS20040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5J25_RS20050	COG2070	2-Nitropropane dioxygenase
H5J25_RS20070	COG0583	DNA-binding transcription factor activity
H5J25_RS20085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5J25_RS20100	COG2267	carboxylic ester hydrolase activity
H5J25_RS20140	COG0613	PHP domain protein
H5J25_RS20170	COG2378	regulation of single-species biofilm formation
H5J25_RS20350	COG3250	beta-galactosidase activity
H5J25_RS20360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde