locus-tag	class	description
AN936_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN936_RS00015	COG0180	Tryptophanyl-tRNA synthetase
AN936_RS00020	COG0728	peptidoglycan biosynthetic process
AN936_RS00025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AN936_RS00035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AN936_RS00045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN936_RS00065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AN936_RS00070	COG0706	membrane insertase activity
AN936_RS00075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AN936_RS00080	COG0594	ribonuclease P activity
AN936_RS00085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AN936_RS00105	COG1309	transcriptional regulator
AN936_RS00130	COG0625	glutathione transferase activity
AN936_RS00135	COG5507	3-demethylubiquinone-9 3-methyltransferase
AN936_RS00190	COG1196	nuclear chromosome segregation
AN936_RS00190	COG0741	lytic transglycosylase activity
AN936_RS00190	COG0739	heme binding
AN936_RS00200	COG4771	TonB-dependent receptor
AN936_RS00205	COG0433	COG0433 Predicted ATPase
AN936_RS00230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AN936_RS00240	COG2897	thiosulfate sulfurtransferase activity
AN936_RS00245	COG0626	cystathionine gamma-synthase activity
AN936_RS00250	COG1196	nuclear chromosome segregation
AN936_RS00250	COG3264	Mechanosensitive ion channel
AN936_RS00255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN936_RS00270	COG0124	histidyl-tRNA synthetase
AN936_RS00275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN936_RS00280	COG2890	protein-(glutamine-N5) methyltransferase activity
AN936_RS00310	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AN936_RS00370	COG2814	Major facilitator Superfamily
AN936_RS00380	COG1301	dicarboxylic acid transport
AN936_RS00385	COG1301	dicarboxylic acid transport
AN936_RS00390	COG0488	(ABC) transporter
AN936_RS00410	COG0138	bifunctional purine biosynthesis protein purh
AN936_RS00455	COG0339	signal peptide processing
AN936_RS00485	COG0194	GDP metabolic process
AN936_RS00500	COG0114	fumarate hydratase activity
AN936_RS00515	COG0131	Imidazoleglycerol-phosphate dehydratase
AN936_RS00520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN936_RS00525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AN936_RS00530	COG0107	imidazoleglycerol-phosphate synthase activity
AN936_RS00535	COG0387	Pfam Sodium calcium exchanger
AN936_RS00560	COG2193	ferroxidase activity
AN936_RS00565	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN936_RS00570	COG0047	phosphoribosylformylglycinamidine synthase activity
AN936_RS00590	COG3590	peptidase
AN936_RS00600	COG0789	Transcriptional regulator
AN936_RS00605	COG3590	peptidase
AN936_RS00610	COG4771	TonB-dependent receptor
AN936_RS00620	COG2814	Major facilitator Superfamily
AN936_RS00630	COG4771	TonB-dependent receptor
AN936_RS00650	COG0028	Belongs to the TPP enzyme family
AN936_RS00655	COG1012	belongs to the aldehyde dehydrogenase family
AN936_RS00665	COG1113	amino acid transport
AN936_RS00685	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AN936_RS00690	COG0730	response to heat
AN936_RS00705	COG0346	lactoylglutathione lyase activity
AN936_RS00710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN936_RS00740	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
AN936_RS00795	COG0481	GTPase activity
AN936_RS00815	COG0482	sulfurtransferase activity
AN936_RS00875	COG1372	Participates in initiation and elongation during chromosome replication
AN936_RS00875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN936_RS00880	COG2852	Protein conserved in bacteria
AN936_RS00885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN936_RS00885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN936_RS00890	COG3300	MHYT domain
AN936_RS00890	COG5001	Diguanylate cyclase
AN936_RS00930	COG2234	aminopeptidase activity
AN936_RS00930	COG4935	Belongs to the peptidase S8 family
AN936_RS00955	COG0436	Aminotransferase
AN936_RS00960	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS00960	COG1506	peptidase
AN936_RS00960	COG4946	Tricorn protease homolog
AN936_RS00975	COG4695	Portal protein
AN936_RS01065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AN936_RS01065	COG2885	chlorophyll binding
AN936_RS01080	COG1132	(ABC) transporter
AN936_RS01095	COG4948	Mandelate Racemase Muconate Lactonizing
AN936_RS01110	COG0789	Transcriptional regulator
AN936_RS01120	COG0183	Belongs to the thiolase family
AN936_RS01145	COG0438	transferase activity, transferring glycosyl groups
AN936_RS01165	COG2932	Transcriptional regulator
AN936_RS01175	COG0840	transmembrane signaling receptor activity
AN936_RS01180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AN936_RS01185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AN936_RS01190	COG2885	chlorophyll binding
AN936_RS01205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN936_RS01215	COG1612	heme a metabolic process
AN936_RS01225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AN936_RS01230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AN936_RS01250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AN936_RS01270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN936_RS01285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN936_RS01300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AN936_RS01315	COG0039	L-malate dehydrogenase activity
AN936_RS01325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AN936_RS01335	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN936_RS01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN936_RS01355	COG2860	membrane
AN936_RS01365	COG0616	signal peptide processing
AN936_RS01375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AN936_RS01385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN936_RS01420	COG1585	Membrane protein implicated in regulation of membrane protease activity
AN936_RS01425	COG0330	HflC and HflK could
AN936_RS01430	COG2301	Belongs to the HpcH HpaI aldolase family
AN936_RS01440	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AN936_RS01450	COG1393	Belongs to the ArsC family
AN936_RS01455	COG0584	glycerophosphoryl diester phosphodiesterase
AN936_RS01465	COG1476	TRANSCRIPTIONal
AN936_RS01475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AN936_RS01490	COG1160	GTP binding
AN936_RS01505	COG2311	Membrane
AN936_RS01525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN936_RS01540	COG1722	exodeoxyribonuclease VII activity
AN936_RS01550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AN936_RS01560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AN936_RS01575	COG1595	DNA-templated transcription, initiation
AN936_RS01585	COG5001	Diguanylate cyclase
AN936_RS01585	COG3300	MHYT domain
AN936_RS01595	COG0343	queuine tRNA-ribosyltransferase activity
AN936_RS01600	COG0784	Response regulator, receiver
AN936_RS01605	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AN936_RS01610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AN936_RS01615	COG2833	Protein of unknown function (DUF455)
AN936_RS01620	COG0741	lytic transglycosylase activity
AN936_RS01620	COG1196	nuclear chromosome segregation
AN936_RS01620	COG0739	heme binding
AN936_RS01645	COG4452	Inner membrane protein CreD
AN936_RS01650	COG1304	FMN binding
AN936_RS01665	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AN936_RS01670	COG2084	Dehydrogenase
AN936_RS01675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN936_RS01705	COG2264	protein methyltransferase activity
AN936_RS01715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN936_RS01720	COG2133	pyrroloquinoline quinone binding
AN936_RS01750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN936_RS01755	COG5001	Diguanylate cyclase
AN936_RS01760	COG0617	tRNA 3'-terminal CCA addition
AN936_RS01835	COG0596	Alpha beta hydrolase
AN936_RS01855	COG1566	PFAM secretion protein HlyD family protein
AN936_RS01860	COG2814	Major facilitator Superfamily
AN936_RS01865	COG0598	Magnesium transport protein CorA
AN936_RS01870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN936_RS01880	COG0488	(ABC) transporter
AN936_RS01910	COG2814	Major facilitator Superfamily
AN936_RS01915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN936_RS01930	COG4771	TonB-dependent receptor
AN936_RS01965	COG1309	transcriptional regulator
AN936_RS01970	COG4771	TonB-dependent receptor
AN936_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS02015	COG1063	alcohol dehydrogenase
AN936_RS02020	COG1024	Enoyl-CoA hydratase
AN936_RS02035	COG1960	acyl-CoA dehydrogenase activity
AN936_RS02040	COG1960	acyl-CoA dehydrogenase activity
AN936_RS02045	COG1012	belongs to the aldehyde dehydrogenase family
AN936_RS02055	COG1024	Enoyl-CoA hydratase
AN936_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS02065	COG0300	oxidoreductase activity
AN936_RS02090	COG1024	Enoyl-CoA hydratase
AN936_RS02090	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN936_RS02095	COG2130	NADP-dependent
AN936_RS02105	COG0183	Belongs to the thiolase family
AN936_RS02115	COG1309	transcriptional regulator
AN936_RS02120	COG1960	acyl-CoA dehydrogenase activity
AN936_RS02125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS02135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN936_RS02135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN936_RS02140	COG1506	peptidase
AN936_RS02140	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS02160	COG1802	Transcriptional regulator
AN936_RS02170	COG3916	Acyl-homoserine-lactone synthase
AN936_RS02175	COG2771	luxR family
AN936_RS02225	COG1396	sequence-specific DNA binding
AN936_RS02230	COG3550	peptidyl-serine autophosphorylation
AN936_RS02310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN936_RS02310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN936_RS02330	COG0672	)-iron permease
AN936_RS02340	COG0789	Transcriptional regulator
AN936_RS02370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN936_RS02390	COG0517	IMP dehydrogenase activity
AN936_RS02395	COG4974	Belongs to the 'phage' integrase family
AN936_RS02425	COG1017	nitric oxide dioxygenase activity
AN936_RS02425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN936_RS02440	COG4191	Histidine kinase
AN936_RS02445	COG4566	intracellular signal transduction
AN936_RS02465	COG1621	beta-fructofuranosidase activity
AN936_RS02470	COG1940	carbohydrate kinase activity
AN936_RS02485	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS02495	COG3547	Transposase (IS116 IS110 IS902 family)
AN936_RS02525	COG5489	Protein of unknown function (DUF736)
AN936_RS02545	COG4959	Type IV secretory pathway protease TraF
AN936_RS02555	COG0741	lytic transglycosylase activity
AN936_RS02595	COG2948	multi-organism process
AN936_RS02610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN936_RS02620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN936_RS02625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AN936_RS02675	COG0745	RESPONSE REGULATOR receiver
AN936_RS02690	COG1024	Enoyl-CoA hydratase
AN936_RS02710	COG0564	pseudouridine synthase activity
AN936_RS02715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN936_RS02735	COG2814	Major facilitator Superfamily
AN936_RS02745	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS02765	COG0657	acetylesterase activity
AN936_RS02775	COG0657	acetylesterase activity
AN936_RS02790	COG1595	DNA-templated transcription, initiation
AN936_RS02800	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS02805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN936_RS02850	COG1309	transcriptional regulator
AN936_RS02870	COG0745	RESPONSE REGULATOR receiver
AN936_RS02890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AN936_RS02895	COG1522	sequence-specific DNA binding
AN936_RS02900	COG3186	Phenylalanine-4-hydroxylase
AN936_RS02905	COG1448	Aminotransferase
AN936_RS02915	COG1595	DNA-templated transcription, initiation
AN936_RS02925	COG2885	chlorophyll binding
AN936_RS02930	COG0730	response to heat
AN936_RS02940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN936_RS02945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN936_RS02955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AN936_RS02975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN936_RS02985	COG3876	Protein conserved in bacteria
AN936_RS02995	COG3739	integral membrane protein
AN936_RS03025	COG0542	response to heat
AN936_RS03040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN936_RS03045	COG0358	DNA primase activity
AN936_RS03060	COG0505	Belongs to the CarA family
AN936_RS03070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN936_RS03085	COG0494	nUDIX hydrolase
AN936_RS03105	COG1970	mechanosensitive ion channel activity
AN936_RS03150	COG4771	TonB-dependent receptor
AN936_RS03155	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS03155	COG1506	peptidase
AN936_RS03155	COG4946	Tricorn protease homolog
AN936_RS03175	COG4771	TonB-dependent receptor
AN936_RS03180	COG0154	amidase activity
AN936_RS03200	COG1228	amidohydrolase
AN936_RS03205	COG3590	peptidase
AN936_RS03235	COG4772	TonB-dependent receptor
AN936_RS03240	COG2366	antibiotic biosynthetic process
AN936_RS03260	COG0583	DNA-binding transcription factor activity
AN936_RS03270	COG0531	amino acid
AN936_RS03275	COG0686	Belongs to the AlaDH PNT family
AN936_RS03285	COG2080	2 iron, 2 sulfur cluster binding
AN936_RS03290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AN936_RS03295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AN936_RS03300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN936_RS03305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AN936_RS03315	COG0137	argininosuccinate synthase activity
AN936_RS03345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN936_RS03430	COG2885	chlorophyll binding
AN936_RS03435	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS03445	COG0848	biopolymer transport protein
AN936_RS03455	COG0824	Thioesterase
AN936_RS03460	COG2255	four-way junction helicase activity
AN936_RS03475	COG0632	four-way junction helicase activity
AN936_RS03480	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AN936_RS03485	COG0217	transcriptional regulatory protein
AN936_RS03490	COG0393	Putative heavy-metal-binding
AN936_RS03500	COG3750	Belongs to the UPF0335 family
AN936_RS03510	COG0469	pyruvate kinase activity
AN936_RS03515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AN936_RS03520	COG0492	ferredoxin-NADP+ reductase activity
AN936_RS03555	COG0215	cysteine-tRNA ligase activity
AN936_RS03595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AN936_RS03600	COG1959	2 iron, 2 sulfur cluster binding
AN936_RS03640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AN936_RS03660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN936_RS03675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN936_RS03685	COG2733	membrane
AN936_RS03695	COG0308	aminopeptidase N
AN936_RS03710	COG1522	sequence-specific DNA binding
AN936_RS03725	COG1127	ABC transporter
AN936_RS03730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN936_RS03745	COG0477	Major facilitator Superfamily
AN936_RS03750	COG1496	oxidoreductase activity
AN936_RS03765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AN936_RS03775	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AN936_RS03780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AN936_RS03785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AN936_RS03805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN936_RS03805	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN936_RS03815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN936_RS03820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN936_RS03825	COG4206	TonB-dependent receptor
AN936_RS03830	COG1506	peptidase
AN936_RS03830	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS03830	COG4946	Tricorn protease homolog
AN936_RS03835	COG1505	serine-type exopeptidase activity
AN936_RS03860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AN936_RS03865	COG2819	hydrolase of the alpha beta superfamily
AN936_RS03885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AN936_RS03905	COG4957	zinc ion binding
AN936_RS03920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN936_RS03925	COG1702	phosphate starvation-inducible protein PhoH
AN936_RS03945	COG3706	GGDEF domain
AN936_RS03950	COG2259	Doxx family
AN936_RS03955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AN936_RS03975	COG0439	Biotin carboxylase
AN936_RS03985	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS03990	COG0183	Belongs to the thiolase family
AN936_RS03995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AN936_RS04000	COG1253	flavin adenine dinucleotide binding
AN936_RS04005	COG0297	glycogen (starch) synthase activity
AN936_RS04010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AN936_RS04035	COG2070	2-Nitropropane dioxygenase
AN936_RS04045	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AN936_RS04105	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AN936_RS04115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN936_RS04125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN936_RS04140	COG4946	Tricorn protease homolog
AN936_RS04140	COG1506	peptidase
AN936_RS04140	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS04155	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN936_RS04160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN936_RS04190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN936_RS04205	COG0538	isocitrate dehydrogenase activity
AN936_RS04210	COG0688	phosphatidylethanolamine metabolic process
AN936_RS04215	COG1183	phosphatidylcholine synthase activity
AN936_RS04225	COG0052	Belongs to the universal ribosomal protein uS2 family
AN936_RS04230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AN936_RS04235	COG0528	UMP kinase activity
AN936_RS04240	COG0233	cytoplasmic translational termination
AN936_RS04245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN936_RS04255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AN936_RS04260	COG0750	zinc metalloprotease
AN936_RS04275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AN936_RS04280	COG0254	rRNA binding
AN936_RS04285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN936_RS04290	COG0513	Belongs to the DEAD box helicase family
AN936_RS04295	COG0477	Major facilitator Superfamily
AN936_RS04340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN936_RS04345	COG3138	arginine N-succinyltransferase
AN936_RS04350	COG3724	N-succinylarginine dihydrolase activity
AN936_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS04385	COG2226	methyltransferase
AN936_RS04390	COG0492	ferredoxin-NADP+ reductase activity
AN936_RS04435	COG0489	protein tyrosine kinase activity
AN936_RS04445	COG3267	Type II secretory pathway component ExeA
AN936_RS04445	COG3409	Peptidoglycan-binding domain 1 protein
AN936_RS04470	COG0367	asparagine synthase
AN936_RS04485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN936_RS04490	COG0424	maF-like protein
AN936_RS04500	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AN936_RS04510	COG0745	RESPONSE REGULATOR receiver
AN936_RS04545	COG2814	Major facilitator Superfamily
AN936_RS04550	COG4206	TonB-dependent receptor
AN936_RS04555	COG1770	oligopeptidase
AN936_RS04570	COG0596	Alpha beta hydrolase
AN936_RS04575	COG2076	Multidrug Resistance protein
AN936_RS04585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN936_RS04595	COG1946	Acyl-CoA thioesterase
AN936_RS04600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AN936_RS04605	COG0081	regulation of translation
AN936_RS04610	COG0346	lactoylglutathione lyase activity
AN936_RS04615	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN936_RS04620	COG4133	protoheme IX ABC transporter activity
AN936_RS04630	COG2154	pterin-4-alpha-carbinolamine dehydratase
AN936_RS04640	COG0531	amino acid
AN936_RS04650	COG3655	Transcriptional regulator
AN936_RS04675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AN936_RS04680	COG0222	ribosome binding
AN936_RS04695	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN936_RS04705	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AN936_RS04710	COG1309	transcriptional regulator
AN936_RS04770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN936_RS04775	COG0540	Belongs to the ATCase OTCase family
AN936_RS04780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN936_RS04790	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AN936_RS04795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN936_RS04800	COG0154	amidase activity
AN936_RS04805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN936_RS04835	COG0544	peptidyl-prolyl cis-trans isomerase activity
AN936_RS04860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN936_RS04870	COG0582	viral genome integration into host DNA
AN936_RS04890	COG4974	Belongs to the 'phage' integrase family
AN936_RS04895	COG0582	viral genome integration into host DNA
AN936_RS04900	COG4974	Belongs to the 'phage' integrase family
AN936_RS04905	COG4974	Belongs to the 'phage' integrase family
AN936_RS04910	COG4974	Belongs to the 'phage' integrase family
AN936_RS04915	COG4974	Belongs to the 'phage' integrase family
AN936_RS04925	COG5642	Protein of unknown function (DUF2384)
AN936_RS04940	COG0071	Belongs to the small heat shock protein (HSP20) family
AN936_RS04945	COG4372	Transposase
AN936_RS04950	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AN936_RS04980	COG3328	transposase activity
AN936_RS04995	COG4227	nucleotidyltransferase activity
AN936_RS05090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AN936_RS05100	COG1074	ATP-dependent DNA helicase activity
AN936_RS05135	COG3328	transposase activity
AN936_RS05300	COG0784	Response regulator, receiver
AN936_RS05300	COG4191	Histidine kinase
AN936_RS05345	COG4451	ribulose bisphosphate carboxylase, small
AN936_RS05375	COG0693	protein deglycase activity
AN936_RS05410	COG3791	Glutathione-dependent formaldehyde-activating
AN936_RS05430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AN936_RS05495	COG3665	Urea carboxylase-associated protein
AN936_RS05500	COG4191	Histidine kinase
AN936_RS05500	COG0784	Response regulator, receiver
AN936_RS05520	COG0492	ferredoxin-NADP+ reductase activity
AN936_RS05525	COG0753	catalase activity
AN936_RS05530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN936_RS05530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AN936_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS05545	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AN936_RS05580	COG3220	belongs to the UPF0276 family
AN936_RS05595	COG2259	Doxx family
AN936_RS05620	COG0668	transmembrane transport
AN936_RS05625	COG0477	Major facilitator Superfamily
AN936_RS05635	COG0527	aspartate kinase activity
AN936_RS05640	COG5285	phytanoyl-CoA dioxygenase
AN936_RS05645	COG1917	Cupin 2, conserved barrel domain protein
AN936_RS05650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AN936_RS05685	COG0583	DNA-binding transcription factor activity
AN936_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS05755	COG0405	Gamma-glutamyltransferase
AN936_RS05770	COG2267	carboxylic ester hydrolase activity
AN936_RS05775	COG0583	DNA-binding transcription factor activity
AN936_RS05795	COG0222	ribosome binding
AN936_RS05810	COG3328	transposase activity
AN936_RS05830	COG0745	RESPONSE REGULATOR receiver
AN936_RS05840	COG4773	Receptor
AN936_RS05850	COG1846	Transcriptional regulator
AN936_RS05860	COG3706	GGDEF domain
AN936_RS05890	COG3920	Histidine kinase
AN936_RS05890	COG2202	Pas domain
AN936_RS05895	COG0625	glutathione transferase activity
AN936_RS05905	COG0405	Gamma-glutamyltransferase
AN936_RS05910	COG1960	acyl-CoA dehydrogenase activity
AN936_RS05915	COG0009	L-threonylcarbamoyladenylate synthase
AN936_RS05975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AN936_RS05985	COG0456	acetyltransferase
AN936_RS06050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN936_RS06055	COG0459	protein refolding
AN936_RS06090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AN936_RS06105	COG1410	methionine synthase
AN936_RS06105	COG0646	methionine synthase
AN936_RS06130	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AN936_RS06145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AN936_RS06150	COG1846	Transcriptional regulator
AN936_RS06155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN936_RS06170	COG2801	Transposase and inactivated derivatives
AN936_RS06205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN936_RS06205	COG1017	nitric oxide dioxygenase activity
AN936_RS06220	COG4191	Histidine kinase
AN936_RS06225	COG4566	intracellular signal transduction
AN936_RS06230	COG0583	DNA-binding transcription factor activity
AN936_RS06275	COG0772	Belongs to the SEDS family
AN936_RS06280	COG0768	penicillin binding
AN936_RS06300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AN936_RS06310	COG3540	Alkaline phosphatase
AN936_RS06320	COG2132	Multicopper oxidase
AN936_RS06330	COG0789	Transcriptional regulator
AN936_RS06335	COG0012	GTP binding
AN936_RS06350	COG4221	oxidoreductase activity
AN936_RS06360	COG0193	aminoacyl-tRNA hydrolase activity
AN936_RS06365	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN936_RS06395	COG0752	glycyl-tRNA synthetase alpha subunit
AN936_RS06400	COG0751	glycine-tRNA ligase activity
AN936_RS06405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN936_RS06405	COG0574	Belongs to the PEP-utilizing enzyme family
AN936_RS06430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AN936_RS06435	COG2819	hydrolase of the alpha beta superfamily
AN936_RS06440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AN936_RS06460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN936_RS06500	COG2205	protein histidine kinase activity
AN936_RS06505	COG1505	serine-type exopeptidase activity
AN936_RS06515	COG0747	negative chemotaxis
AN936_RS06530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN936_RS06550	COG1131	(ABC) transporter
AN936_RS06555	COG0842	Transport permease protein
AN936_RS06560	COG0776	regulation of translation
AN936_RS06565	COG0539	negative regulation of cytoplasmic translation
AN936_RS06570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AN936_RS06580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN936_RS06620	COG1024	Enoyl-CoA hydratase
AN936_RS06635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AN936_RS06645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AN936_RS06655	COG0582	viral genome integration into host DNA
AN936_RS06670	COG0517	IMP dehydrogenase activity
AN936_RS06675	COG4974	Belongs to the 'phage' integrase family
AN936_RS06685	COG0303	'Molybdopterin
AN936_RS06690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AN936_RS06695	COG0243	molybdopterin cofactor binding
AN936_RS06705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN936_RS06715	COG2223	nitrite transmembrane transporter activity
AN936_RS06720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN936_RS06720	COG1116	anion transmembrane transporter activity
AN936_RS06740	COG2205	protein histidine kinase activity
AN936_RS06755	COG3268	Saccharopine dehydrogenase
AN936_RS06770	COG0717	Belongs to the dCTP deaminase family
AN936_RS06775	COG0295	cytidine deaminase activity
AN936_RS06785	COG5328	Belongs to the UPF0262 family
AN936_RS06790	COG0305	Participates in initiation and elongation during chromosome replication
AN936_RS06795	COG2827	Endonuclease containing a URI domain
AN936_RS06810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN936_RS06825	COG1012	belongs to the aldehyde dehydrogenase family
AN936_RS06830	COG0596	Alpha beta hydrolase
AN936_RS06835	COG0438	transferase activity, transferring glycosyl groups
AN936_RS06845	COG2827	Endonuclease containing a URI domain
AN936_RS06850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AN936_RS06870	COG0183	Belongs to the thiolase family
AN936_RS06875	COG1012	belongs to the aldehyde dehydrogenase family
AN936_RS06895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AN936_RS06910	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AN936_RS06940	COG1475	DNA binding
AN936_RS06985	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AN936_RS06990	COG2948	multi-organism process
AN936_RS06995	COG3504	Conjugal transfer protein
AN936_RS07000	COG3736	Type IV secretory pathway, component VirB8
AN936_RS07020	COG3451	type IV secretory pathway VirB4
AN936_RS07025	COG3702	type iv secretory pathway
AN936_RS07040	COG2771	luxR family
AN936_RS07045	COG2801	Transposase and inactivated derivatives
AN936_RS07085	COG3328	transposase activity
AN936_RS07090	COG0837	glucose binding
AN936_RS07095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AN936_RS07105	COG2354	Protein conserved in bacteria
AN936_RS07115	COG1177	transmembrane transport
AN936_RS07130	COG0174	glutamine synthetase
AN936_RS07135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AN936_RS07140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN936_RS07155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN936_RS07160	COG1278	Cold shock
AN936_RS07200	COG4964	Belongs to the GSP D family
AN936_RS07220	COG0328	RNA-DNA hybrid ribonuclease activity
AN936_RS07225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AN936_RS07230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AN936_RS07240	COG0018	arginyl-trna synthetase
AN936_RS07250	COG1472	Belongs to the glycosyl hydrolase 3 family
AN936_RS07255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AN936_RS07260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AN936_RS07265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN936_RS07270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN936_RS07275	COG0805	protein transport
AN936_RS07280	COG5510	response to toxic substance
AN936_RS07285	COG2239	Acts as a magnesium transporter
AN936_RS07295	COG2070	2-Nitropropane dioxygenase
AN936_RS07320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AN936_RS07330	COG0314	molybdopterin synthase activity
AN936_RS07345	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AN936_RS07385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN936_RS07400	COG5002	protein histidine kinase activity
AN936_RS07410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN936_RS07415	COG2333	competence protein COMEC
AN936_RS07415	COG0658	competence protein
AN936_RS07420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN936_RS07425	COG0303	'Molybdopterin
AN936_RS07430	COG0315	cyclic pyranopterin monophosphate synthase activity
AN936_RS07435	COG0134	indole-3-glycerol-phosphate synthase activity
AN936_RS07440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AN936_RS07450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AN936_RS07460	COG0149	triose-phosphate isomerase activity
AN936_RS07470	COG0504	CTP synthase activity
AN936_RS07485	COG1136	(ABC) transporter
AN936_RS07490	COG0386	Belongs to the glutathione peroxidase family
AN936_RS07515	COG0521	Mo-molybdopterin cofactor biosynthetic process
AN936_RS07540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AN936_RS07550	COG0129	dihydroxy-acid dehydratase activity
AN936_RS07560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AN936_RS07560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AN936_RS07565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN936_RS07580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS07610	COG1446	asparaginase
AN936_RS07620	COG0596	Alpha beta hydrolase
AN936_RS07625	COG1748	Saccharopine dehydrogenase
AN936_RS07660	COG0156	8-amino-7-oxononanoate synthase activity
AN936_RS07670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN936_RS07680	COG0758	DNA mediated transformation
AN936_RS07695	COG1754	DNA topoisomerase type I activity
AN936_RS07695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN936_RS07710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN936_RS07715	COG0571	ribonuclease III activity
AN936_RS07720	COG0681	Belongs to the peptidase S26 family
AN936_RS07725	COG0166	Belongs to the GPI family
AN936_RS07740	COG1396	sequence-specific DNA binding
AN936_RS07740	COG3800	Transcriptional regulator
AN936_RS07745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN936_RS07755	COG0346	lactoylglutathione lyase activity
AN936_RS07760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AN936_RS07760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AN936_RS07780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AN936_RS07785	COG3755	Protein conserved in bacteria
AN936_RS07790	COG4770	biotin carboxylase activity
AN936_RS07795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN936_RS07800	COG3104	oligopeptide transport
AN936_RS07810	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AN936_RS07815	COG0477	Major facilitator Superfamily
AN936_RS07820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN936_RS07825	COG4771	TonB-dependent receptor
AN936_RS07840	COG0442	prolyl-tRNA aminoacylation
AN936_RS07850	COG0557	exoribonuclease II activity
AN936_RS07870	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN936_RS07880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN936_RS07890	COG0671	phosphoesterase, PA-phosphatase related
AN936_RS07900	COG1228	amidohydrolase
AN936_RS07910	COG1024	Enoyl-CoA hydratase
AN936_RS07915	COG1960	acyl-CoA dehydrogenase activity
AN936_RS07920	COG1960	acyl-CoA dehydrogenase activity
AN936_RS07925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS07935	COG0183	Belongs to the thiolase family
AN936_RS07945	COG1960	acyl-CoA dehydrogenase activity
AN936_RS07950	COG1960	acyl-CoA dehydrogenase activity
AN936_RS07965	COG1960	acyl-CoA dehydrogenase activity
AN936_RS07980	COG1024	Enoyl-CoA hydratase
AN936_RS07985	COG1024	Enoyl-CoA hydratase
AN936_RS07995	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08000	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08035	COG0657	acetylesterase activity
AN936_RS08040	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08085	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS08110	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08115	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08120	COG1024	Enoyl-CoA hydratase
AN936_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08130	COG1024	Enoyl-CoA hydratase
AN936_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08145	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08160	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08170	COG4771	TonB-dependent receptor
AN936_RS08205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08225	COG4221	oxidoreductase activity
AN936_RS08230	COG0477	Major facilitator Superfamily
AN936_RS08250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS08285	COG3328	transposase activity
AN936_RS08290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN936_RS08300	COG1024	Enoyl-CoA hydratase
AN936_RS08410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AN936_RS08415	COG1573	uracil-dna glycosylase
AN936_RS08420	COG1051	belongs to the nudix hydrolase family
AN936_RS08425	COG0657	acetylesterase activity
AN936_RS08430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AN936_RS08430	COG0674	pyruvate-flavodoxin oxidoreductase activity
AN936_RS08435	COG1013	pyruvate-flavodoxin oxidoreductase activity
AN936_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS08465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AN936_RS08470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AN936_RS08480	COG0789	Transcriptional regulator
AN936_RS08485	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08500	COG2030	dehydratase
AN936_RS08515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN936_RS08520	COG3590	peptidase
AN936_RS08535	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08545	COG0175	sulfate reduction
AN936_RS08555	COG1218	3'(2'),5'-bisphosphate nucleotidase
AN936_RS08560	COG1063	alcohol dehydrogenase
AN936_RS08620	COG0277	FAD linked oxidase domain protein
AN936_RS08635	COG2130	NADP-dependent
AN936_RS08660	COG0477	Major facilitator Superfamily
AN936_RS08665	COG0742	ribosomal rna small subunit methyltransferase
AN936_RS08670	COG1187	pseudouridine synthase activity
AN936_RS08680	COG2211	Major facilitator Superfamily
AN936_RS08685	COG0285	dihydrofolate synthase activity
AN936_RS08690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AN936_RS08695	COG0159	tryptophan synthase activity
AN936_RS08705	COG0133	tryptophan synthase activity
AN936_RS08710	COG0135	phosphoribosylanthranilate isomerase activity
AN936_RS08715	COG0284	orotidine-5'-phosphate decarboxylase activity
AN936_RS08725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN936_RS08745	COG2003	Belongs to the UPF0758 family
AN936_RS08770	COG0356	it plays a direct role in the translocation of protons across the membrane
AN936_RS08780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN936_RS08785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN936_RS08800	COG0288	reversible hydration of carbon dioxide
AN936_RS08805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN936_RS08820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AN936_RS08820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AN936_RS08840	COG5000	phosphorelay sensor kinase activity
AN936_RS08845	COG2204	response regulator
AN936_RS08850	COG1923	regulation of RNA biosynthetic process
AN936_RS08855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AN936_RS08860	COG3956	TIGRFAM MazG family protein
AN936_RS08870	COG0084	hydrolase, TatD family'
AN936_RS08880	COG0470	DNA polymerase III
AN936_RS08885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN936_RS08890	COG1686	Belongs to the peptidase S11 family
AN936_RS08900	COG2951	lytic endotransglycosylase activity
AN936_RS08940	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08945	COG1960	acyl-CoA dehydrogenase activity
AN936_RS08965	COG0625	glutathione transferase activity
AN936_RS08970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS08975	COG1228	amidohydrolase
AN936_RS08995	COG0842	Transport permease protein
AN936_RS09015	COG0187	DNA topoisomerase II activity
AN936_RS09030	COG2967	ApaG domain
AN936_RS09040	COG0473	3-isopropylmalate dehydrogenase activity
AN936_RS09045	COG1381	Involved in DNA repair and RecF pathway recombination
AN936_RS09055	COG0322	excinuclease ABC activity
AN936_RS09060	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AN936_RS09090	COG0346	lactoylglutathione lyase activity
AN936_RS09100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN936_RS09115	COG2205	protein histidine kinase activity
AN936_RS09120	COG1522	sequence-specific DNA binding
AN936_RS09150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AN936_RS09160	COG1007	ATP synthesis coupled electron transport
AN936_RS09175	COG0713	ATP synthesis coupled electron transport
AN936_RS09185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN936_RS09190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AN936_RS09195	COG1034	ATP synthesis coupled electron transport
AN936_RS09205	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AN936_RS09220	COG0649	NAD binding
AN936_RS09225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN936_RS09230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN936_RS09235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN936_RS09245	COG0483	inositol monophosphate 1-phosphatase activity
AN936_RS09250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN936_RS09255	COG1297	OPT oligopeptide transporter protein
AN936_RS09260	COG0739	heme binding
AN936_RS09270	COG0352	thiamine-phosphate diphosphorylase activity
AN936_RS09280	COG4122	O-methyltransferase activity
AN936_RS09285	COG3588	fructose-bisphosphate aldolase
AN936_RS09295	COG0126	phosphoglycerate kinase activity
AN936_RS09300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN936_RS09320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AN936_RS09335	COG0628	permease
AN936_RS09375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AN936_RS09380	COG2003	Belongs to the UPF0758 family
AN936_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS09410	COG2267	carboxylic ester hydrolase activity
AN936_RS09420	COG4774	siderophore transport
AN936_RS09425	COG3128	pkhd-type hydroxylase
AN936_RS09430	COG1477	protein flavinylation
AN936_RS09450	COG0519	Catalyzes the synthesis of GMP from XMP
AN936_RS09450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN936_RS09470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN936_RS09475	COG2857	Cytochrome c1
AN936_RS09475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AN936_RS09485	COG0723	plastoquinol--plastocyanin reductase activity
AN936_RS09490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN936_RS09495	COG0408	coproporphyrinogen oxidase activity
AN936_RS09510	COG0321	lipoyl(octanoyl) transferase activity
AN936_RS09520	COG0602	queuosine metabolic process
AN936_RS09525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AN936_RS09540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AN936_RS09545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AN936_RS09550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN936_RS09565	COG0667	Aldo Keto reductase
AN936_RS09585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN936_RS09595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN936_RS09615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN936_RS09620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN936_RS09625	COG0546	phosphoglycolate phosphatase activity
AN936_RS09675	COG1794	racemase activity, acting on amino acids and derivatives
AN936_RS09690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AN936_RS09695	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AN936_RS09720	COG0640	Transcriptional regulator
AN936_RS09730	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AN936_RS09740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN936_RS09745	COG0351	phosphomethylpyrimidine kinase
AN936_RS09750	COG3813	Protein conserved in bacteria
AN936_RS09755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN936_RS09765	COG0667	Aldo Keto reductase
AN936_RS09785	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AN936_RS09790	COG1228	amidohydrolase
AN936_RS09795	COG3104	oligopeptide transport
AN936_RS09805	COG2188	Transcriptional regulator
AN936_RS09815	COG2204	response regulator
AN936_RS09820	COG4191	Histidine kinase
AN936_RS09825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AN936_RS09830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN936_RS09830	COG3153	acetyltransferase
AN936_RS09850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN936_RS09855	COG2203	Gaf domain
AN936_RS09855	COG4251	negative regulation of phosphorylation
AN936_RS09855	COG3706	GGDEF domain
AN936_RS09855	COG5001	Diguanylate cyclase
AN936_RS09875	COG0861	Integral membrane protein TerC family
AN936_RS09885	COG1024	Enoyl-CoA hydratase
AN936_RS09900	COG1473	amidohydrolase
AN936_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS09920	COG2321	neutral zinc metallopeptidase
AN936_RS09925	COG1228	amidohydrolase
AN936_RS09940	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS09940	COG1506	peptidase
AN936_RS09945	COG0525	valine-tRNA ligase activity
AN936_RS09955	COG0534	Mate efflux family protein
AN936_RS09960	COG3275	phosphorelay sensor kinase activity
AN936_RS09980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN936_RS09985	COG3590	peptidase
AN936_RS09990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AN936_RS10005	COG3328	transposase activity
AN936_RS10015	COG0573	inorganic phosphate transmembrane transporter activity
AN936_RS10025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN936_RS10030	COG0704	Plays a role in the regulation of phosphate uptake
AN936_RS10035	COG0745	RESPONSE REGULATOR receiver
AN936_RS10045	COG3746	phosphate-selective porin O and P
AN936_RS10050	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS10065	COG1045	serine acetyltransferase
AN936_RS10075	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN936_RS10075	COG0022	dehydrogenase e1 component
AN936_RS10080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AN936_RS10095	COG0148	phosphopyruvate hydratase activity
AN936_RS10130	COG1643	Atp-dependent helicase
AN936_RS10140	COG0142	geranyltranstransferase activity
AN936_RS10145	COG0287	Prephenate dehydrogenase
AN936_RS10145	COG1605	Chorismate mutase
AN936_RS10150	COG0625	glutathione transferase activity
AN936_RS10175	COG0776	regulation of translation
AN936_RS10185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AN936_RS10205	COG1104	cysteine desulfurase activity
AN936_RS10210	COG2945	thiolester hydrolase activity
AN936_RS10225	COG0698	ribose 5-phosphate isomerase
AN936_RS10230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN936_RS10240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN936_RS10255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AN936_RS10270	COG2957	Belongs to the agmatine deiminase family
AN936_RS10275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN936_RS10275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN936_RS10320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN936_RS10325	COG4774	siderophore transport
AN936_RS10330	COG1737	Transcriptional regulator
AN936_RS10340	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS10345	COG3268	Saccharopine dehydrogenase
AN936_RS10355	COG4771	TonB-dependent receptor
AN936_RS10360	COG2197	response regulator
AN936_RS10380	COG3949	Membrane
AN936_RS10400	COG4948	Mandelate Racemase Muconate Lactonizing
AN936_RS10405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AN936_RS10455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AN936_RS10470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN936_RS10475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN936_RS10490	COG1472	Belongs to the glycosyl hydrolase 3 family
AN936_RS10560	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AN936_RS10565	COG0109	protoheme IX farnesyltransferase activity
AN936_RS10570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AN936_RS10580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AN936_RS10585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AN936_RS10590	COG0736	holo-[acyl-carrier-protein] synthase activity
AN936_RS10605	COG0545	Peptidyl-prolyl cis-trans isomerase
AN936_RS10610	COG1758	RNA polymerase activity
AN936_RS10630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN936_RS10650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN936_RS10655	COG5006	permease, DMT superfamily
AN936_RS10675	COG0354	folic acid binding
AN936_RS10680	COG0418	dihydroorotase activity
AN936_RS10720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AN936_RS10725	COG0235	Class ii aldolase
AN936_RS10740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN936_RS10745	COG3300	MHYT domain
AN936_RS10745	COG5001	Diguanylate cyclase
AN936_RS10760	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AN936_RS10775	COG2062	phosphohistidine phosphatase, SixA
AN936_RS10785	COG0776	regulation of translation
AN936_RS10790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN936_RS10795	COG0416	fatty acid biosynthetic process
AN936_RS10800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AN936_RS10805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN936_RS10810	COG2119	membrane
AN936_RS10830	COG0729	surface antigen
AN936_RS10835	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AN936_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS10900	COG0583	DNA-binding transcription factor activity
AN936_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS10960	COG4774	siderophore transport
AN936_RS10990	COG0574	Belongs to the PEP-utilizing enzyme family
AN936_RS10990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN936_RS11005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AN936_RS11025	COG1024	Enoyl-CoA hydratase
AN936_RS11035	COG1609	Transcriptional regulator
AN936_RS11040	COG1472	Belongs to the glycosyl hydrolase 3 family
AN936_RS11050	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
AN936_RS11060	COG2272	Belongs to the type-B carboxylesterase lipase family
AN936_RS11125	COG1505	serine-type exopeptidase activity
AN936_RS11135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN936_RS11155	COG3473	Maleate cis-trans isomerase
AN936_RS11160	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN936_RS11180	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AN936_RS11185	COG3483	tryptophan 2,3-dioxygenase activity
AN936_RS11190	COG3186	Phenylalanine-4-hydroxylase
AN936_RS11200	COG1522	sequence-specific DNA binding
AN936_RS11210	COG2828	Protein conserved in bacteria
AN936_RS11225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AN936_RS11230	COG3800	Transcriptional regulator
AN936_RS11230	COG1396	sequence-specific DNA binding
AN936_RS11240	COG0483	inositol monophosphate 1-phosphatase activity
AN936_RS11245	COG0673	inositol 2-dehydrogenase activity
AN936_RS11260	COG2271	Major facilitator Superfamily
AN936_RS11265	COG3718	enzyme involved in inositol metabolism
AN936_RS11275	COG3962	Belongs to the TPP enzyme family
AN936_RS11280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN936_RS11285	COG1737	Transcriptional regulator
AN936_RS11290	COG0673	inositol 2-dehydrogenase activity
AN936_RS11335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AN936_RS11340	COG0028	Belongs to the TPP enzyme family
AN936_RS11350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AN936_RS11365	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AN936_RS11370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AN936_RS11410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN936_RS11440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN936_RS11455	COG4941	Belongs to the sigma-70 factor family
AN936_RS11460	COG3795	YCII-related domain
AN936_RS11490	COG3158	transport of potassium into the cell
AN936_RS11495	COG4235	cytochrome complex assembly
AN936_RS11500	COG3088	subunit of a heme lyase
AN936_RS11510	COG1138	Cytochrome C-type biogenesis protein
AN936_RS11515	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AN936_RS11520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN936_RS11525	COG2832	Protein of unknown function (DUF454)
AN936_RS11550	COG0488	(ABC) transporter
AN936_RS11565	COG0438	transferase activity, transferring glycosyl groups
AN936_RS11570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN936_RS11575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN936_RS11580	COG1862	Preprotein translocase
AN936_RS11620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN936_RS11640	COG0010	Belongs to the arginase family
AN936_RS11645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AN936_RS11660	COG3590	peptidase
AN936_RS11670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AN936_RS11675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN936_RS11680	COG0741	lytic transglycosylase activity
AN936_RS11695	COG3023	N-Acetylmuramoyl-L-alanine amidase
AN936_RS11700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AN936_RS11705	COG2201	protein-glutamate methylesterase activity
AN936_RS11720	COG0643	Histidine kinase
AN936_RS11720	COG0784	Response regulator, receiver
AN936_RS11720	COG2198	Histidine kinase
AN936_RS11730	COG0564	pseudouridine synthase activity
AN936_RS11735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN936_RS11750	COG0484	heat shock protein binding
AN936_RS11770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AN936_RS11785	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AN936_RS11790	COG0248	Ppx GppA phosphatase
AN936_RS11795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AN936_RS11810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AN936_RS11815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AN936_RS11820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN936_RS11830	COG0105	UTP biosynthetic process
AN936_RS11840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN936_RS11850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN936_RS11855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AN936_RS11860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN936_RS11870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AN936_RS11895	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AN936_RS11900	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS11905	COG0183	Belongs to the thiolase family
AN936_RS11910	COG0183	Belongs to the thiolase family
AN936_RS11925	COG0824	Thioesterase
AN936_RS11940	COG2207	Transcriptional regulator
AN936_RS11945	COG2814	Major facilitator Superfamily
AN936_RS11950	COG0746	molybdenum cofactor guanylyltransferase activity
AN936_RS11955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN936_RS11960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS11965	COG0625	glutathione transferase activity
AN936_RS11970	COG0625	glutathione transferase activity
AN936_RS11990	COG0625	glutathione transferase activity
AN936_RS11995	COG4221	oxidoreductase activity
AN936_RS12000	COG2814	Major facilitator Superfamily
AN936_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS12045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN936_RS12050	COG0596	Alpha beta hydrolase
AN936_RS12055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN936_RS12075	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS12080	COG1846	Transcriptional regulator
AN936_RS12090	COG2022	thiamine diphosphate biosynthetic process
AN936_RS12100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AN936_RS12110	COG0439	Biotin carboxylase
AN936_RS12125	COG1393	Belongs to the ArsC family
AN936_RS12140	COG1136	(ABC) transporter
AN936_RS12140	COG0577	efflux transmembrane transporter activity
AN936_RS12145	COG0577	efflux transmembrane transporter activity
AN936_RS12145	COG1136	(ABC) transporter
AN936_RS12155	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS12160	COG2267	carboxylic ester hydrolase activity
AN936_RS12165	COG0583	DNA-binding transcription factor activity
AN936_RS12170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN936_RS12185	COG4771	TonB-dependent receptor
AN936_RS12190	COG0006	proline dipeptidase activity
AN936_RS12215	COG0443	Heat shock 70 kDa protein
AN936_RS12220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN936_RS12240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AN936_RS12245	COG0085	RNA polymerase activity
AN936_RS12265	COG4771	TonB-dependent receptor
AN936_RS12280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AN936_RS12285	COG4774	siderophore transport
AN936_RS12290	COG3119	arylsulfatase activity
AN936_RS12310	COG0277	FAD linked oxidase domain protein
AN936_RS12315	COG4771	TonB-dependent receptor
AN936_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS12325	COG2272	Belongs to the type-B carboxylesterase lipase family
AN936_RS12330	COG1522	sequence-specific DNA binding
AN936_RS12360	COG3383	formate dehydrogenase (NAD+) activity
AN936_RS12370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AN936_RS12375	COG2188	Transcriptional regulator
AN936_RS12385	COG1228	amidohydrolase
AN936_RS12390	COG2986	histidine ammonia-lyase
AN936_RS12400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AN936_RS12410	COG3706	GGDEF domain
AN936_RS12445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN936_RS12450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN936_RS12460	COG0509	glycine decarboxylation via glycine cleavage system
AN936_RS12465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN936_RS12475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AN936_RS12490	COG0849	cell division
AN936_RS12495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AN936_RS12500	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN936_RS12505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AN936_RS12510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN936_RS12515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN936_RS12525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN936_RS12530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN936_RS12535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN936_RS12540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN936_RS12555	COG0275	rRNA processing
AN936_RS12560	COG2001	Belongs to the MraZ family
AN936_RS12580	COG4771	TonB-dependent receptor
AN936_RS12595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AN936_RS12605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN936_RS12610	COG0360	Binds together with S18 to 16S ribosomal RNA
AN936_RS12615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AN936_RS12620	COG0359	binds to the 23S rRNA
AN936_RS12625	COG0302	gtp cyclohydrolase
AN936_RS12630	COG4771	TonB-dependent receptor
AN936_RS12635	COG4771	TonB-dependent receptor
AN936_RS12640	COG4946	Tricorn protease homolog
AN936_RS12640	COG0823	Involved in the tonB-independent uptake of proteins
AN936_RS12640	COG1506	peptidase
AN936_RS12645	COG2814	Major facilitator Superfamily
AN936_RS12665	COG1012	belongs to the aldehyde dehydrogenase family
AN936_RS12680	COG0583	DNA-binding transcription factor activity
AN936_RS12700	COG4771	TonB-dependent receptor
AN936_RS12765	COG3328	transposase activity
AN936_RS12780	COG2132	Multicopper oxidase
AN936_RS12795	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AN936_RS12795	COG1473	amidohydrolase
AN936_RS12820	COG2264	protein methyltransferase activity
AN936_RS12830	COG1937	Protein conserved in bacteria
AN936_RS12885	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN936_RS12945	COG0681	Belongs to the peptidase S26 family
AN936_RS13010	COG0625	glutathione transferase activity
AN936_RS13015	COG0277	FAD linked oxidase domain protein
AN936_RS13025	COG3328	transposase activity
AN936_RS13030	COG0277	FAD linked oxidase domain protein
AN936_RS13035	COG0625	glutathione transferase activity
AN936_RS13040	COG1942	4-Oxalocrotonate Tautomerase
AN936_RS13060	COG3328	transposase activity
AN936_RS13065	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AN936_RS13090	COG3328	transposase activity
AN936_RS13110	COG2211	Major facilitator Superfamily
AN936_RS13125	COG2211	Major facilitator Superfamily
AN936_RS13170	COG2211	Major facilitator Superfamily
AN936_RS13205	COG0629	single-stranded DNA binding
AN936_RS13235	COG4227	nucleotidyltransferase activity
AN936_RS13250	COG4974	Belongs to the 'phage' integrase family
AN936_RS13255	COG4974	Belongs to the 'phage' integrase family
AN936_RS13260	COG4974	Belongs to the 'phage' integrase family
AN936_RS13270	COG4974	Belongs to the 'phage' integrase family
AN936_RS13275	COG0582	viral genome integration into host DNA
AN936_RS13280	COG4974	Belongs to the 'phage' integrase family
AN936_RS13305	COG3328	transposase activity
AN936_RS13310	COG0582	viral genome integration into host DNA
AN936_RS13335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AN936_RS13340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AN936_RS13360	COG0556	nucleotide-excision repair
AN936_RS13375	COG1309	transcriptional regulator
AN936_RS13390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AN936_RS13400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AN936_RS13405	COG0792	nuclease activity
AN936_RS13410	COG0189	ligase activity
AN936_RS13415	COG0586	Pfam SNARE associated Golgi protein
AN936_RS13420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AN936_RS13425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN936_RS13435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AN936_RS13440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AN936_RS13445	COG1420	regulation of RNA biosynthetic process
AN936_RS13450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN936_RS13455	COG0242	peptide deformylase activity
AN936_RS13465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN936_RS13470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AN936_RS13475	COG0101	tRNA pseudouridine synthase activity
AN936_RS13480	COG1329	Transcriptional regulator
AN936_RS13485	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS13490	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AN936_RS13495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AN936_RS13500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN936_RS13505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN936_RS13510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN936_RS13565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AN936_RS13570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AN936_RS13585	COG2363	Small membrane protein
AN936_RS13590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN936_RS13600	COG0306	phosphate transporter
AN936_RS13605	COG1392	Phosphate transport regulator
AN936_RS13610	COG2072	flavoprotein involved in K transport
AN936_RS13625	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS13635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN936_RS13640	COG0791	NLP P60 protein
AN936_RS13680	COG1733	regulation of RNA biosynthetic process
AN936_RS13685	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AN936_RS13695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN936_RS13705	COG0076	glutamate decarboxylase activity
AN936_RS13715	COG1742	UPF0060 membrane protein
AN936_RS13720	COG2258	MOSC domain
AN936_RS13730	COG4181	ATPase activity
AN936_RS13755	COG1408	metallophosphoesterase
AN936_RS13760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AN936_RS13770	COG1968	undecaprenyl-diphosphatase activity
AN936_RS13805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN936_RS13810	COG0527	aspartate kinase activity
AN936_RS13830	COG2197	response regulator
AN936_RS13835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AN936_RS13840	COG4948	Mandelate Racemase Muconate Lactonizing
AN936_RS13850	COG0531	amino acid
AN936_RS13855	COG0457	Tetratricopeptide repeat
AN936_RS13865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AN936_RS13875	COG1737	Transcriptional regulator
AN936_RS13885	COG0436	Aminotransferase
AN936_RS13890	COG1396	sequence-specific DNA binding
AN936_RS13900	COG0436	Aminotransferase
AN936_RS13910	COG0066	3-isopropylmalate dehydratase activity
AN936_RS13915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AN936_RS13920	COG0583	DNA-binding transcription factor activity
AN936_RS13925	COG4771	TonB-dependent receptor
AN936_RS13930	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AN936_RS13935	COG1473	amidohydrolase
AN936_RS13945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN936_RS13955	COG0583	DNA-binding transcription factor activity
AN936_RS13970	COG0251	oxidation-reduction process
AN936_RS14000	COG4771	TonB-dependent receptor
AN936_RS14020	COG0745	RESPONSE REGULATOR receiver
AN936_RS14025	COG2205	protein histidine kinase activity
AN936_RS14030	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AN936_RS14035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AN936_RS14055	COG2801	Transposase and inactivated derivatives
AN936_RS14075	COG2072	flavoprotein involved in K transport
AN936_RS14085	COG1960	acyl-CoA dehydrogenase activity
AN936_RS14090	COG1960	acyl-CoA dehydrogenase activity
AN936_RS14105	COG2070	2-Nitropropane dioxygenase
AN936_RS14120	COG0633	Ferredoxin
AN936_RS14140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN936_RS14140	COG0596	Alpha beta hydrolase
AN936_RS14160	COG4206	TonB-dependent receptor
AN936_RS14180	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS14200	COG3436	PFAM IS66 Orf2 family protein
AN936_RS14205	COG4372	Transposase
AN936_RS14225	COG1127	ABC transporter
AN936_RS14240	COG2801	Transposase and inactivated derivatives
AN936_RS14245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN936_RS14270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AN936_RS14305	COG4771	TonB-dependent receptor
AN936_RS14320	COG3436	PFAM IS66 Orf2 family protein
AN936_RS14330	COG2801	Transposase and inactivated derivatives
AN936_RS14465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AN936_RS14495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN936_RS14515	COG3328	transposase activity
AN936_RS14525	COG3177	Filamentation induced by cAMP protein fic
AN936_RS14535	COG0604	alcohol dehydrogenase
AN936_RS14580	COG2723	6-phospho-beta-galactosidase activity
AN936_RS14590	COG4771	TonB-dependent receptor
AN936_RS14595	COG1609	Transcriptional regulator
AN936_RS14665	COG4974	Belongs to the 'phage' integrase family
AN936_RS14670	COG0582	viral genome integration into host DNA
AN936_RS14675	COG4974	Belongs to the 'phage' integrase family
AN936_RS14740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN936_RS14760	COG0167	dihydroorotate dehydrogenase activity
AN936_RS14780	COG0719	Fe-S assembly protein
AN936_RS14790	COG0396	ATPase activity
AN936_RS14795	COG0719	Fe-S assembly protein
AN936_RS14800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AN936_RS14805	COG2151	metal-sulfur cluster biosynthetic enzyme
AN936_RS14810	COG0316	Belongs to the HesB IscA family
AN936_RS14830	COG1301	dicarboxylic acid transport
AN936_RS14835	COG0471	metal ion transport
AN936_RS14835	COG3273	potassium ion transport
AN936_RS14840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AN936_RS14850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AN936_RS14855	COG1295	ribonuclease BN
AN936_RS14860	COG0484	heat shock protein binding
AN936_RS14865	COG0259	pyridoxamine-phosphate oxidase activity
AN936_RS14875	COG0475	glutathione-regulated potassium exporter activity
AN936_RS14895	COG4977	sequence-specific DNA binding
AN936_RS14905	COG0596	Alpha beta hydrolase
AN936_RS14915	COG1741	Belongs to the pirin family
AN936_RS14955	COG0477	Major facilitator Superfamily
AN936_RS14965	COG3328	transposase activity
AN936_RS14970	COG0028	Belongs to the TPP enzyme family
AN936_RS14975	COG2827	Endonuclease containing a URI domain
AN936_RS14980	COG1012	belongs to the aldehyde dehydrogenase family
AN936_RS14990	COG0438	transferase activity, transferring glycosyl groups
AN936_RS15000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN936_RS15000	COG0519	Catalyzes the synthesis of GMP from XMP
AN936_RS15010	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS15030	COG1024	Enoyl-CoA hydratase
AN936_RS15035	COG1960	acyl-CoA dehydrogenase activity
AN936_RS15040	COG1960	acyl-CoA dehydrogenase activity
AN936_RS15045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS15060	COG0183	Belongs to the thiolase family
AN936_RS15075	COG1024	Enoyl-CoA hydratase
AN936_RS15085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AN936_RS15105	COG2124	cytochrome p450
AN936_RS15110	COG1960	acyl-CoA dehydrogenase activity
AN936_RS15125	COG0243	molybdopterin cofactor binding
AN936_RS15140	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS15165	COG4771	TonB-dependent receptor
AN936_RS15195	COG0243	molybdopterin cofactor binding
AN936_RS15200	COG2814	Major facilitator Superfamily
AN936_RS15225	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS15230	COG4638	Rieske (2fe-2S)
AN936_RS15235	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AN936_RS15240	COG4771	TonB-dependent receptor
AN936_RS15255	COG1218	3'(2'),5'-bisphosphate nucleotidase
AN936_RS15265	COG0175	sulfate reduction
AN936_RS15290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN936_RS15295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AN936_RS15310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN936_RS15310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN936_RS15315	COG0443	Heat shock 70 kDa protein
AN936_RS15330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AN936_RS15335	COG1605	Chorismate mutase
AN936_RS15335	COG0077	Prephenate dehydratase
AN936_RS15345	COG3474	cytochrome
AN936_RS15360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AN936_RS15365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN936_RS15380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN936_RS15385	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AN936_RS15400	COG2814	Major facilitator Superfamily
AN936_RS15405	COG0154	amidase activity
AN936_RS15415	COG0436	Aminotransferase
AN936_RS15420	COG3243	poly(R)-hydroxyalkanoic acid synthase
AN936_RS15430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN936_RS15465	COG4774	siderophore transport
AN936_RS15475	COG0436	Aminotransferase
AN936_RS15480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AN936_RS15480	COG1648	precorrin-2 dehydrogenase activity
AN936_RS15485	COG0019	diaminopimelate decarboxylase activity
AN936_RS15495	COG0165	Argininosuccinate lyase
AN936_RS15500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN936_RS15505	COG1414	Transcriptional regulator
AN936_RS15510	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS15515	COG2030	dehydratase
AN936_RS15525	COG0183	Belongs to the thiolase family
AN936_RS15540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN936_RS15550	COG2267	carboxylic ester hydrolase activity
AN936_RS15565	COG2937	Belongs to the GPAT DAPAT family
AN936_RS15575	COG0800	Aldolase
AN936_RS15580	COG0129	dihydroxy-acid dehydratase activity
AN936_RS15585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AN936_RS15605	COG3634	alkyl hydroperoxide reductase activity
AN936_RS15610	COG0450	alkyl hydroperoxide reductase
AN936_RS15615	COG2814	Major facilitator Superfamily
AN936_RS15620	COG0583	DNA-binding transcription factor activity
AN936_RS15630	COG1566	PFAM secretion protein HlyD family protein
AN936_RS15655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS15660	COG0183	Belongs to the thiolase family
AN936_RS15670	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AN936_RS15675	COG1285	pathogenesis
AN936_RS15685	COG4771	TonB-dependent receptor
AN936_RS15715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AN936_RS15720	COG1040	competence protein
AN936_RS15730	COG0494	nUDIX hydrolase
AN936_RS15750	COG0825	malonyl-CoA metabolic process
AN936_RS15755	COG4974	Belongs to the 'phage' integrase family
AN936_RS15775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AN936_RS15800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN936_RS15805	COG1024	Enoyl-CoA hydratase
AN936_RS15815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN936_RS15835	COG2308	Evidence 4 Homologs of previously reported genes of
AN936_RS15840	COG0653	protein targeting
AN936_RS15855	COG0300	oxidoreductase activity
AN936_RS15885	COG2081	HI0933 family
AN936_RS15900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AN936_RS15920	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AN936_RS15925	COG0583	DNA-binding transcription factor activity
AN936_RS15935	COG1760	l-serine dehydratase
AN936_RS15940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AN936_RS15950	COG1793	dna ligase
AN936_RS15950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AN936_RS15955	COG1573	uracil-dna glycosylase
AN936_RS15965	COG3920	Histidine kinase
AN936_RS15965	COG2202	Pas domain
AN936_RS15970	COG0784	Response regulator, receiver
AN936_RS15975	COG0583	DNA-binding transcription factor activity
AN936_RS16015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AN936_RS16020	COG0066	3-isopropylmalate dehydratase activity
AN936_RS16025	COG3321	synthase
AN936_RS16025	COG0604	alcohol dehydrogenase
AN936_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS16080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AN936_RS16085	COG0678	peroxiredoxin activity
AN936_RS16085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AN936_RS16090	COG1678	Uncharacterized ACR, COG1678
AN936_RS16100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AN936_RS16105	COG2205	protein histidine kinase activity
AN936_RS16110	COG0802	atpase or kinase
AN936_RS16115	COG3178	'Phosphotransferase
AN936_RS16120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AN936_RS16125	COG2887	Belongs to the helicase family. UvrD subfamily
AN936_RS16130	COG1074	ATP-dependent DNA helicase activity
AN936_RS16140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AN936_RS16155	COG1476	TRANSCRIPTIONal
AN936_RS16165	COG0174	glutamine synthetase
AN936_RS16180	COG0024	Methionine aminopeptidase
AN936_RS16205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AN936_RS16210	COG3738	Protein conserved in bacteria
AN936_RS16215	COG0335	large ribosomal subunit rRNA binding
AN936_RS16220	COG0336	Belongs to the RNA methyltransferase TrmD family
AN936_RS16235	COG0583	DNA-binding transcription factor activity
AN936_RS16250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN936_RS16255	COG0228	four-way junction DNA binding
AN936_RS16260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AN936_RS16265	COG5001	Diguanylate cyclase
AN936_RS16265	COG3300	MHYT domain
AN936_RS16270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AN936_RS16275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN936_RS16280	COG0552	protein localization to endoplasmic reticulum
AN936_RS16285	COG2917	probably involved in intracellular septation
AN936_RS16295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AN936_RS16305	COG0113	porphobilinogen synthase activity
AN936_RS16310	COG0739	heme binding
AN936_RS16325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AN936_RS16330	COG0740	serine-type endopeptidase activity
AN936_RS16335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AN936_RS16350	COG2166	iron-sulfur cluster assembly
AN936_RS16390	COG1842	Phage shock protein A
AN936_RS16395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AN936_RS16405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN936_RS16410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AN936_RS16445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AN936_RS16450	COG0745	RESPONSE REGULATOR receiver
AN936_RS16455	COG2205	protein histidine kinase activity
AN936_RS16460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AN936_RS16465	COG1660	Displays ATPase and GTPase activities
AN936_RS16470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN936_RS16470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN936_RS16480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN936_RS16490	COG1322	Protein conserved in bacteria
AN936_RS16505	COG0443	Heat shock 70 kDa protein
AN936_RS16510	COG0484	heat shock protein binding
AN936_RS16520	COG1752	Esterase of the alpha-beta hydrolase superfamily
AN936_RS16550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AN936_RS16555	COG2169	Transcriptional regulator
AN936_RS16555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN936_RS16570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN936_RS16580	COG0412	Dienelactone hydrolase
AN936_RS16585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN936_RS16590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AN936_RS16595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AN936_RS16600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AN936_RS16605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AN936_RS16610	COG3842	ATPase activity
AN936_RS16645	COG0730	response to heat
AN936_RS16660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN936_RS16700	COG1024	Enoyl-CoA hydratase
AN936_RS16740	COG2086	electron transfer activity
AN936_RS16745	COG0045	succinate-CoA ligase (ADP-forming) activity
AN936_RS16760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN936_RS16770	COG4771	TonB-dependent receptor
AN936_RS16775	COG0436	Aminotransferase
AN936_RS16790	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS16810	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AN936_RS16810	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AN936_RS16880	COG0612	Peptidase, M16
AN936_RS16890	COG0753	catalase activity
AN936_RS16895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN936_RS16900	COG1024	Enoyl-CoA hydratase
AN936_RS16920	COG1956	GAF domain-containing protein
AN936_RS16930	COG1505	serine-type exopeptidase activity
AN936_RS16940	COG3011	Protein conserved in bacteria
AN936_RS16960	COG0203	ribosomal protein L17
AN936_RS16965	COG0202	RNA polymerase activity
AN936_RS16970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AN936_RS16975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN936_RS16985	COG0312	modulator of DNA gyrase
AN936_RS17000	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AN936_RS17010	COG0793	Belongs to the peptidase S41A family
AN936_RS17020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AN936_RS17025	COG0799	negative regulation of ribosome biogenesis
AN936_RS17030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AN936_RS17045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AN936_RS17105	COG0564	pseudouridine synthase activity
AN936_RS17110	COG3384	dioxygenase
AN936_RS17115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AN936_RS17125	COG0583	DNA-binding transcription factor activity
AN936_RS17160	COG0686	Belongs to the AlaDH PNT family
AN936_RS17165	COG1522	sequence-specific DNA binding
AN936_RS17175	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS17180	COG2264	protein methyltransferase activity
AN936_RS17185	COG3186	Phenylalanine-4-hydroxylase
AN936_RS17190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AN936_RS17195	COG4149	molybdate abc transporter
AN936_RS17200	COG0725	ABC transporter, periplasmic molybdate-binding protein
AN936_RS17225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN936_RS17245	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN936_RS17265	COG1185	polyribonucleotide nucleotidyltransferase activity
AN936_RS17270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AN936_RS17275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN936_RS17290	COG1435	thymidine kinase activity
AN936_RS17300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AN936_RS17310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN936_RS17315	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AN936_RS17325	COG0779	Required for maturation of 30S ribosomal subunits
AN936_RS17330	COG4372	Transposase
AN936_RS17335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AN936_RS17360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AN936_RS17375	COG2137	regulation of response to DNA damage stimulus
AN936_RS17380	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS17385	COG5001	Diguanylate cyclase
AN936_RS17400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN936_RS17405	COG0330	HflC and HflK could
AN936_RS17415	COG0489	protein tyrosine kinase activity
AN936_RS17420	COG1832	CoA-binding protein
AN936_RS17435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AN936_RS17440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AN936_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS17490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN936_RS17505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN936_RS17520	COG1473	amidohydrolase
AN936_RS17530	COG1505	serine-type exopeptidase activity
AN936_RS17555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AN936_RS17570	COG2816	NAD+ diphosphatase activity
AN936_RS17600	COG1196	nuclear chromosome segregation
AN936_RS17605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AN936_RS17625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN936_RS17645	COG0783	Belongs to the Dps family
AN936_RS17670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AN936_RS17685	COG0196	riboflavin kinase activity
AN936_RS17700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN936_RS17705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AN936_RS17720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN936_RS17745	COG0670	Belongs to the BI1 family
AN936_RS17760	COG1063	alcohol dehydrogenase
AN936_RS17770	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS17795	COG1063	alcohol dehydrogenase
AN936_RS17840	COG4774	siderophore transport
AN936_RS17855	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AN936_RS17860	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS17885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AN936_RS17890	COG0583	DNA-binding transcription factor activity
AN936_RS17910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AN936_RS17925	COG2814	Major facilitator Superfamily
AN936_RS17950	COG0604	alcohol dehydrogenase
AN936_RS17955	COG0583	DNA-binding transcription factor activity
AN936_RS17960	COG0667	Aldo Keto reductase
AN936_RS17985	COG0798	PFAM Bile acid sodium symporter
AN936_RS18020	COG1126	abc transporter atp-binding protein
AN936_RS18025	COG0626	cystathionine gamma-synthase activity
AN936_RS18030	COG4597	amino acid ABC transporter
AN936_RS18035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN936_RS18040	COG0583	DNA-binding transcription factor activity
AN936_RS18075	COG1595	DNA-templated transcription, initiation
AN936_RS18105	COG2226	methyltransferase
AN936_RS18135	COG4957	zinc ion binding
AN936_RS18165	COG0500	methyltransferase
AN936_RS18180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AN936_RS18190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AN936_RS18205	COG0037	tRNA processing
AN936_RS18255	COG2003	Belongs to the UPF0758 family
AN936_RS18280	COG0367	asparagine synthase
AN936_RS18310	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AN936_RS18335	COG4206	TonB-dependent receptor
AN936_RS18345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN936_RS18350	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AN936_RS18360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN936_RS18365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AN936_RS18370	COG1086	Polysaccharide biosynthesis protein
AN936_RS18455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AN936_RS18460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AN936_RS18465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AN936_RS18525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AN936_RS18535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN936_RS18540	COG1674	ftsk spoiiie
AN936_RS18560	COG3279	Response regulator of the LytR AlgR family
AN936_RS18565	COG3275	phosphorelay sensor kinase activity
AN936_RS18605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN936_RS18620	COG1522	sequence-specific DNA binding
AN936_RS18670	COG1764	response to oxidative stress
AN936_RS18690	COG1671	Belongs to the UPF0178 family
AN936_RS18700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AN936_RS18705	COG0140	phosphoribosyl-ATP diphosphatase activity
AN936_RS18715	COG2373	Large extracellular alpha-helical protein
AN936_RS18720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN936_RS18725	COG0531	amino acid
AN936_RS18730	COG2814	Major facilitator Superfamily
AN936_RS18740	COG0612	Peptidase, M16
AN936_RS18750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN936_RS18755	COG0542	response to heat
AN936_RS18760	COG4771	TonB-dependent receptor
AN936_RS18790	COG0457	Tetratricopeptide repeat
AN936_RS18810	COG1570	exodeoxyribonuclease VII activity
AN936_RS18815	COG0151	Belongs to the GarS family
AN936_RS18820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN936_RS18820	COG3743	rRNA binding
AN936_RS18825	COG0670	Belongs to the BI1 family
AN936_RS18830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AN936_RS18835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AN936_RS18840	COG2814	Major facilitator Superfamily
AN936_RS18845	COG2032	superoxide dismutase activity
AN936_RS18850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AN936_RS18890	COG1494	fructose-1,6-bisphosphatase
AN936_RS18895	COG1253	flavin adenine dinucleotide binding
AN936_RS18900	COG2885	chlorophyll binding
AN936_RS18905	COG2095	MarC family integral membrane protein
AN936_RS18915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN936_RS18925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN936_RS18935	COG1506	peptidase
AN936_RS18940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AN936_RS18955	COG0596	Alpha beta hydrolase
AN936_RS18965	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN936_RS18970	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AN936_RS18975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AN936_RS18990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN936_RS19010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AN936_RS19020	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS19025	COG1960	acyl-CoA dehydrogenase activity
AN936_RS19030	COG1960	acyl-CoA dehydrogenase activity
AN936_RS19035	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS19040	COG2211	Major facilitator Superfamily
AN936_RS19045	COG1960	acyl-CoA dehydrogenase activity
AN936_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS19070	COG0667	Aldo Keto reductase
AN936_RS19080	COG1024	Enoyl-CoA hydratase
AN936_RS19080	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN936_RS19100	COG1024	Enoyl-CoA hydratase
AN936_RS19105	COG1024	Enoyl-CoA hydratase
AN936_RS19140	COG0246	Mannitol dehydrogenase
AN936_RS19145	COG1904	glucuronate isomerase
AN936_RS19150	COG2271	Major facilitator Superfamily
AN936_RS19160	COG1609	Transcriptional regulator
AN936_RS19180	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS19185	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AN936_RS19195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN936_RS19215	COG0587	DNA-directed DNA polymerase activity
AN936_RS19225	COG1677	Flagellar hook-basal body complex protein FliE
AN936_RS19235	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AN936_RS19285	COG1987	bacterial-type flagellum assembly
AN936_RS19290	COG1684	flagellar biosynthetic protein fliR
AN936_RS19295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AN936_RS19315	COG1360	Flagellar Motor Protein
AN936_RS19320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN936_RS19340	COG1706	bacterial-type flagellum-dependent cell motility
AN936_RS19345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AN936_RS19360	COG4786	Flagellar basal body rod
AN936_RS19370	COG1558	bacterial-type flagellum-dependent cell motility
AN936_RS19430	COG2186	Transcriptional regulator
AN936_RS19440	COG4948	Mandelate Racemase Muconate Lactonizing
AN936_RS19465	COG1454	alcohol dehydrogenase
AN936_RS19480	COG2197	response regulator
AN936_RS19490	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AN936_RS19530	COG1309	transcriptional regulator
AN936_RS19540	COG4773	Receptor
AN936_RS19545	COG4974	Belongs to the 'phage' integrase family
AN936_RS19550	COG0517	IMP dehydrogenase activity
AN936_RS19555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN936_RS19580	COG2010	Cytochrome c
AN936_RS19615	COG4974	Belongs to the 'phage' integrase family
AN936_RS19620	COG3621	Patatin-like phospholipase
AN936_RS19630	COG1396	sequence-specific DNA binding
AN936_RS19680	COG4227	nucleotidyltransferase activity
AN936_RS19725	COG4974	Belongs to the 'phage' integrase family
AN936_RS19730	COG0582	viral genome integration into host DNA
AN936_RS19735	COG4974	Belongs to the 'phage' integrase family
AN936_RS19765	COG5489	Protein of unknown function (DUF736)
AN936_RS19770	COG3550	peptidyl-serine autophosphorylation
AN936_RS19775	COG3620	sequence-specific DNA binding
AN936_RS19795	COG1192	Involved in chromosome partitioning
AN936_RS19820	COG0741	lytic transglycosylase activity
AN936_RS19845	COG3846	protein secretion by the type IV secretion system
AN936_RS19860	COG2948	multi-organism process
AN936_RS19880	COG3415	Transposase
AN936_RS19880	COG2801	Transposase and inactivated derivatives
AN936_RS19900	COG3328	transposase activity
AN936_RS19920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AN936_RS19935	COG1074	ATP-dependent DNA helicase activity
AN936_RS19945	COG3328	transposase activity
AN936_RS19960	COG3328	transposase activity
AN936_RS19975	COG0430	RNA-3'-phosphate cyclase activity
AN936_RS19985	COG3541	Predicted nucleotidyltransferase
AN936_RS19990	COG1690	Belongs to the RtcB family
AN936_RS19995	COG4650	regulator
AN936_RS20000	COG2855	membrane
AN936_RS20010	COG2884	Cell division ATP-binding protein ftsE
AN936_RS20030	COG0287	Prephenate dehydrogenase
AN936_RS20035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN936_RS20040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN936_RS20045	COG2813	Specifically methylates the guanine in position
AN936_RS20045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN936_RS20050	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN936_RS20080	COG1309	transcriptional regulator
AN936_RS20085	COG4771	TonB-dependent receptor
AN936_RS20090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN936_RS20095	COG1960	acyl-CoA dehydrogenase activity
AN936_RS20110	COG0181	hydroxymethylbilane synthase activity
AN936_RS20115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AN936_RS20120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN936_RS20135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN936_RS20150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AN936_RS20155	COG4152	abc transporter atp-binding protein
AN936_RS20180	COG0024	Methionine aminopeptidase
AN936_RS20195	COG0730	response to heat
AN936_RS20225	COG0357	Ribosomal RNA small subunit methyltransferase G
AN936_RS20230	COG0445	tRNA wobble uridine modification
AN936_RS20235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AN936_RS20255	COG0069	glutamate synthase activity
AN936_RS20265	COG0861	Integral membrane protein TerC family
AN936_RS20275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AN936_RS20280	COG1981	membrane
AN936_RS20285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AN936_RS20290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AN936_RS20295	COG0424	maF-like protein
AN936_RS20300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AN936_RS20305	COG0237	dephospho-CoA kinase activity
AN936_RS20310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN936_RS20315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN936_RS20320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN936_RS20340	COG2866	Carboxypeptidase
AN936_RS20345	COG0454	-acetyltransferase
AN936_RS20350	COG0071	Belongs to the small heat shock protein (HSP20) family
AN936_RS20355	COG0588	phosphoglycerate mutase activity
AN936_RS20370	COG2171	N-acyltransferase activity
AN936_RS20380	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AN936_RS20390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AN936_RS20395	COG0049	tRNA binding
AN936_RS20400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN936_RS20405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN936_RS20410	COG0051	transcription antitermination factor activity, RNA binding
AN936_RS20415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AN936_RS20420	COG0088	Forms part of the polypeptide exit tunnel
AN936_RS20425	COG0089	rRNA binding
AN936_RS20430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AN936_RS20435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AN936_RS20440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AN936_RS20445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AN936_RS20450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AN936_RS20455	COG0255	Belongs to the universal ribosomal protein uL29 family
AN936_RS20460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AN936_RS20465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AN936_RS20470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AN936_RS20475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN936_RS20480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN936_RS20485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AN936_RS20490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AN936_RS20495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AN936_RS20500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AN936_RS20505	COG1841	ribosomal large subunit assembly
AN936_RS20515	COG0200	Binds to the 23S rRNA
AN936_RS20520	COG0201	protein transport
AN936_RS20525	COG0563	adenylate kinase activity
AN936_RS20550	COG0281	malic enzyme
AN936_RS20550	COG0280	phosphate acetyltransferase
AN936_RS20555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AN936_RS20560	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AN936_RS20570	COG0072	phenylalanine-tRNA ligase activity
AN936_RS20575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AN936_RS20590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AN936_RS20595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AN936_RS20620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN936_RS20630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN936_RS20670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AN936_RS20685	COG1137	ATPase activity
AN936_RS20690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AN936_RS20695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN936_RS20715	COG0006	proline dipeptidase activity
AN936_RS20730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN936_RS20730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN936_RS20745	COG0629	single-stranded DNA binding
AN936_RS20750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AN936_RS20750	COG1918	ferrous iron import across plasma membrane
AN936_RS20770	COG1902	pentaerythritol trinitrate reductase activity
AN936_RS20780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AN936_RS20795	COG1999	signal sequence binding
AN936_RS20800	COG2983	Belongs to the UPF0260 family
AN936_RS20810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN936_RS20815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN936_RS20820	COG0644	oxidoreductase
AN936_RS20850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AN936_RS20870	COG0495	leucyl-tRNA aminoacylation
AN936_RS20905	COG1278	Cold shock
AN936_RS20925	COG5265	(ABC) transporter
AN936_RS20930	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
AN936_RS20940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN936_RS20940	COG4651	solute:proton antiporter activity
AN936_RS20945	COG0514	ATP-dependent DNA helicase (RecQ)
AN936_RS20965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AN936_RS20985	COG0004	ammonium transporteR
AN936_RS20990	COG0347	Belongs to the P(II) protein family
AN936_RS21030	COG0312	modulator of DNA gyrase
AN936_RS21050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AN936_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
AN936_RS21090	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AN936_RS21095	COG1217	gtp-binding protein TYPA
AN936_RS21105	COG1271	oxidase subunit
AN936_RS21110	COG1294	oxidase, subunit
AN936_RS21145	COG2175	clavaminate synthase activity
AN936_RS21150	COG4335	DNA alkylation repair
AN936_RS21190	COG1960	acyl-CoA dehydrogenase activity
AN936_RS21195	COG1473	amidohydrolase
AN936_RS21210	COG1131	(ABC) transporter
AN936_RS21240	COG2066	Belongs to the glutaminase family
AN936_RS21260	COG1201	RNA secondary structure unwinding
AN936_RS21270	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AN936_RS21270	COG0778	Nitroreductase
AN936_RS21290	COG0714	Associated with various cellular activities
AN936_RS21315	COG4566	intracellular signal transduction
AN936_RS21325	COG2723	6-phospho-beta-galactosidase activity
AN936_RS21345	COG2814	Major facilitator Superfamily
AN936_RS21380	COG1741	Belongs to the pirin family
AN936_RS21385	COG1741	Belongs to the pirin family
AN936_RS21390	COG0583	DNA-binding transcription factor activity
AN936_RS21395	COG0583	DNA-binding transcription factor activity
AN936_RS21400	COG2814	Major facilitator Superfamily
AN936_RS21420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AN936_RS21435	COG1335	isochorismatase
AN936_RS21440	COG4771	TonB-dependent receptor
AN936_RS21445	COG2814	Major facilitator Superfamily
AN936_RS21455	COG0318	PFAM AMP-dependent synthetase and ligase
AN936_RS21465	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS21490	COG0531	amino acid
AN936_RS21505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN936_RS21510	COG3938	Belongs to the proline racemase family
AN936_RS21515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN936_RS21525	COG1228	amidohydrolase
AN936_RS21530	COG1309	transcriptional regulator
AN936_RS21535	COG1131	(ABC) transporter
AN936_RS21740	COG3750	Belongs to the UPF0335 family
AN936_RS21880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AN936_RS21890	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AN936_RS21905	COG1058	Belongs to the CinA family
AN936_RS21905	COG1546	Belongs to the CinA family
AN936_RS21940	COG3177	Filamentation induced by cAMP protein fic
AN936_RS21950	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AN936_RS21975	COG1942	4-Oxalocrotonate Tautomerase
AN936_RS21990	COG0583	DNA-binding transcription factor activity
AN936_RS22020	COG3665	Urea carboxylase-associated protein
AN936_RS22025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AN936_RS22035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN936_RS22045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AN936_RS22050	COG0248	Ppx GppA phosphatase
AN936_RS22065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN936_RS22070	COG0590	tRNA wobble adenosine to inosine editing
AN936_RS22075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AN936_RS22080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN936_RS22085	COG0501	Belongs to the peptidase M48B family
AN936_RS22090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AN936_RS22095	COG1028	Short-chain dehydrogenase reductase Sdr
AN936_RS22100	COG1309	transcriptional regulator
AN936_RS22105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN936_RS22110	COG2207	Transcriptional regulator
AN936_RS22115	COG4221	oxidoreductase activity
AN936_RS22120	COG1309	transcriptional regulator
AN936_RS22125	COG4638	Rieske (2fe-2S)
AN936_RS22140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN936_RS22145	COG0531	amino acid
AN936_RS22155	COG0457	Tetratricopeptide repeat
AN936_RS22170	COG1530	ribonuclease E activity
AN936_RS22175	COG0860	N-Acetylmuramoyl-L-alanine amidase
AN936_RS22195	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AN936_RS22220	COG0756	dUTP diphosphatase activity
AN936_RS22225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AN936_RS22245	COG2226	methyltransferase
AN936_RS22250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AN936_RS22255	COG0268	Binds directly to 16S ribosomal RNA
AN936_RS22265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN936_RS22775	COG4771	TonB-dependent receptor
AN936_RS23165	COG0728	peptidoglycan biosynthetic process
AN936_RS23175	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AN936_RS23250	COG0706	membrane insertase activity
AN936_RS23860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division