locus-tag	class	description
SPYCW_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPYCW_RS00015	COG0180	Tryptophanyl-tRNA synthetase
SPYCW_RS00020	COG0728	peptidoglycan biosynthetic process
SPYCW_RS00025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SPYCW_RS00035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SPYCW_RS00045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYCW_RS00055	COG1280	lysine exporter protein (LysE YggA)
SPYCW_RS00065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SPYCW_RS00070	COG0706	membrane insertase activity
SPYCW_RS00075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPYCW_RS00080	COG0594	ribonuclease P activity
SPYCW_RS00105	COG0625	glutathione transferase activity
SPYCW_RS00120	COG5507	3-demethylubiquinone-9 3-methyltransferase
SPYCW_RS00130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPYCW_RS00150	COG1309	transcriptional regulator
SPYCW_RS00175	COG0739	heme binding
SPYCW_RS00175	COG1196	nuclear chromosome segregation
SPYCW_RS00175	COG0741	lytic transglycosylase activity
SPYCW_RS00200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYCW_RS00280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SPYCW_RS00290	COG4650	regulator
SPYCW_RS00295	COG1690	Belongs to the RtcB family
SPYCW_RS00305	COG0430	RNA-3'-phosphate cyclase activity
SPYCW_RS00335	COG0577	efflux transmembrane transporter activity
SPYCW_RS00335	COG1136	(ABC) transporter
SPYCW_RS00345	COG1538	Outer membrane efflux protein
SPYCW_RS00350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SPYCW_RS00355	COG0583	DNA-binding transcription factor activity
SPYCW_RS00365	COG4948	Mandelate Racemase Muconate Lactonizing
SPYCW_RS00370	COG1301	dicarboxylic acid transport
SPYCW_RS00375	COG2223	nitrite transmembrane transporter activity
SPYCW_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS00440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPYCW_RS00445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPYCW_RS00455	COG1832	CoA-binding protein
SPYCW_RS00460	COG0489	protein tyrosine kinase activity
SPYCW_RS00465	COG0330	HflC and HflK could
SPYCW_RS00475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYCW_RS00485	COG0433	COG0433 Predicted ATPase
SPYCW_RS00510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SPYCW_RS00520	COG2897	thiosulfate sulfurtransferase activity
SPYCW_RS00525	COG0626	cystathionine gamma-synthase activity
SPYCW_RS00530	COG1196	nuclear chromosome segregation
SPYCW_RS00530	COG3264	Mechanosensitive ion channel
SPYCW_RS00535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SPYCW_RS00545	COG0124	histidyl-tRNA synthetase
SPYCW_RS00550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPYCW_RS00555	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYCW_RS00585	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SPYCW_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS00640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPYCW_RS00665	COG1136	(ABC) transporter
SPYCW_RS00675	COG0488	(ABC) transporter
SPYCW_RS00705	COG0138	bifunctional purine biosynthesis protein purh
SPYCW_RS00745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYCW_RS00765	COG0339	signal peptide processing
SPYCW_RS00780	COG0183	Belongs to the thiolase family
SPYCW_RS00795	COG0194	GDP metabolic process
SPYCW_RS00805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYCW_RS00815	COG0114	fumarate hydratase activity
SPYCW_RS00830	COG0131	Imidazoleglycerol-phosphate dehydratase
SPYCW_RS00835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SPYCW_RS00840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPYCW_RS00845	COG0107	imidazoleglycerol-phosphate synthase activity
SPYCW_RS00850	COG0387	Pfam Sodium calcium exchanger
SPYCW_RS00865	COG0730	response to heat
SPYCW_RS00890	COG4771	TonB-dependent receptor
SPYCW_RS00920	COG1309	transcriptional regulator
SPYCW_RS00925	COG4771	TonB-dependent receptor
SPYCW_RS00960	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS00970	COG1063	alcohol dehydrogenase
SPYCW_RS00975	COG1024	Enoyl-CoA hydratase
SPYCW_RS00990	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS00995	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS01000	COG1012	belongs to the aldehyde dehydrogenase family
SPYCW_RS01010	COG1024	Enoyl-CoA hydratase
SPYCW_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS01020	COG0300	oxidoreductase activity
SPYCW_RS01045	COG1024	Enoyl-CoA hydratase
SPYCW_RS01045	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPYCW_RS01050	COG2130	NADP-dependent
SPYCW_RS01060	COG0183	Belongs to the thiolase family
SPYCW_RS01070	COG1309	transcriptional regulator
SPYCW_RS01075	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS01080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPYCW_RS01095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPYCW_RS01095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SPYCW_RS01100	COG0823	Involved in the tonB-independent uptake of proteins
SPYCW_RS01100	COG1506	peptidase
SPYCW_RS01135	COG1017	nitric oxide dioxygenase activity
SPYCW_RS01135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPYCW_RS01150	COG4191	Histidine kinase
SPYCW_RS01155	COG4566	intracellular signal transduction
SPYCW_RS01175	COG1621	beta-fructofuranosidase activity
SPYCW_RS01180	COG1940	carbohydrate kinase activity
SPYCW_RS01195	COG0318	PFAM AMP-dependent synthetase and ligase
SPYCW_RS01215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPYCW_RS01220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPYCW_RS01225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SPYCW_RS01270	COG0318	PFAM AMP-dependent synthetase and ligase
SPYCW_RS01275	COG0745	RESPONSE REGULATOR receiver
SPYCW_RS01315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPYCW_RS01335	COG1609	Transcriptional regulator
SPYCW_RS01355	COG0837	glucose binding
SPYCW_RS01360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SPYCW_RS01400	COG0823	Involved in the tonB-independent uptake of proteins
SPYCW_RS01400	COG4946	Tricorn protease homolog
SPYCW_RS01400	COG1506	peptidase
SPYCW_RS01415	COG3706	GGDEF domain
SPYCW_RS01450	COG2202	Pas domain
SPYCW_RS01450	COG3920	Histidine kinase
SPYCW_RS01465	COG0598	Magnesium transport protein CorA
SPYCW_RS01515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPYCW_RS01520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPYCW_RS01545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPYCW_RS01550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SPYCW_RS01575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPYCW_RS01610	COG3186	Phenylalanine-4-hydroxylase
SPYCW_RS01615	COG2264	protein methyltransferase activity
SPYCW_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS01630	COG1522	sequence-specific DNA binding
SPYCW_RS01635	COG0686	Belongs to the AlaDH PNT family
SPYCW_RS01680	COG1872	DUF167
SPYCW_RS01685	COG3321	synthase
SPYCW_RS01685	COG0604	alcohol dehydrogenase
SPYCW_RS01690	COG0066	3-isopropylmalate dehydratase activity
SPYCW_RS01700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPYCW_RS01715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPYCW_RS01760	COG0583	DNA-binding transcription factor activity
SPYCW_RS01840	COG0617	tRNA 3'-terminal CCA addition
SPYCW_RS01850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPYCW_RS01865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYCW_RS01910	COG0564	pseudouridine synthase activity
SPYCW_RS01915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPYCW_RS01940	COG2234	aminopeptidase activity
SPYCW_RS01960	COG1956	GAF domain-containing protein
SPYCW_RS01965	COG1505	serine-type exopeptidase activity
SPYCW_RS01975	COG0203	ribosomal protein L17
SPYCW_RS01980	COG0202	RNA polymerase activity
SPYCW_RS01985	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPYCW_RS01990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SPYCW_RS02005	COG0483	inositol monophosphate 1-phosphatase activity
SPYCW_RS02010	COG0312	modulator of DNA gyrase
SPYCW_RS02030	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SPYCW_RS02040	COG0793	Belongs to the peptidase S41A family
SPYCW_RS02050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SPYCW_RS02055	COG0799	negative regulation of ribosome biogenesis
SPYCW_RS02060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPYCW_RS02070	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SPYCW_RS02080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SPYCW_RS02095	COG1024	Enoyl-CoA hydratase
SPYCW_RS02100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPYCW_RS02105	COG0753	catalase activity
SPYCW_RS02125	COG0612	Peptidase, M16
SPYCW_RS02130	COG0789	Transcriptional regulator
SPYCW_RS02155	COG0047	phosphoribosylformylglycinamidine synthase activity
SPYCW_RS02160	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYCW_RS02170	COG2193	ferroxidase activity
SPYCW_RS02195	COG0183	Belongs to the thiolase family
SPYCW_RS02220	COG0438	transferase activity, transferring glycosyl groups
SPYCW_RS02240	COG2932	Transcriptional regulator
SPYCW_RS02250	COG0840	transmembrane signaling receptor activity
SPYCW_RS02255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYCW_RS02260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPYCW_RS02270	COG2199	diguanylate cyclase activity
SPYCW_RS02280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS02290	COG1612	heme a metabolic process
SPYCW_RS02300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYCW_RS02305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPYCW_RS02335	COG0420	3'-5' exonuclease activity
SPYCW_RS02345	COG0657	acetylesterase activity
SPYCW_RS02355	COG1213	nucleotidyl transferase
SPYCW_RS02385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPYCW_RS02395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SPYCW_RS02405	COG0039	L-malate dehydrogenase activity
SPYCW_RS02425	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYCW_RS02430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYCW_RS02435	COG1473	amidohydrolase
SPYCW_RS02440	COG2860	membrane
SPYCW_RS02455	COG0616	signal peptide processing
SPYCW_RS02465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SPYCW_RS02475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPYCW_RS02505	COG1585	Membrane protein implicated in regulation of membrane protease activity
SPYCW_RS02510	COG0330	HflC and HflK could
SPYCW_RS02525	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SPYCW_RS02535	COG1393	Belongs to the ArsC family
SPYCW_RS02540	COG0584	glycerophosphoryl diester phosphodiesterase
SPYCW_RS02545	COG1476	TRANSCRIPTIONal
SPYCW_RS02555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPYCW_RS02570	COG1160	GTP binding
SPYCW_RS02585	COG2311	Membrane
SPYCW_RS02605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYCW_RS02620	COG1722	exodeoxyribonuclease VII activity
SPYCW_RS02625	COG0142	geranyltranstransferase activity
SPYCW_RS02630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SPYCW_RS02640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPYCW_RS02680	COG5001	Diguanylate cyclase
SPYCW_RS02690	COG0343	queuine tRNA-ribosyltransferase activity
SPYCW_RS02695	COG0784	Response regulator, receiver
SPYCW_RS02700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SPYCW_RS02705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPYCW_RS02710	COG2833	Protein of unknown function (DUF455)
SPYCW_RS02715	COG4942	peptidase
SPYCW_RS02730	COG0456	acetyltransferase
SPYCW_RS02785	COG0534	Mate efflux family protein
SPYCW_RS02795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPYCW_RS02800	COG0459	protein refolding
SPYCW_RS02850	COG0646	methionine synthase
SPYCW_RS02850	COG1410	methionine synthase
SPYCW_RS02875	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYCW_RS02890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYCW_RS02895	COG1846	Transcriptional regulator
SPYCW_RS02900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYCW_RS02910	COG0025	NhaP-type Na H and K H
SPYCW_RS02915	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS02920	COG1024	Enoyl-CoA hydratase
SPYCW_RS02930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPYCW_RS02945	COG3119	arylsulfatase activity
SPYCW_RS02980	COG1459	type II secretion system
SPYCW_RS02990	COG2165	general secretion pathway protein
SPYCW_RS03025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SPYCW_RS03030	COG2885	chlorophyll binding
SPYCW_RS03035	COG0823	Involved in the tonB-independent uptake of proteins
SPYCW_RS03045	COG0848	biopolymer transport protein
SPYCW_RS03055	COG0824	Thioesterase
SPYCW_RS03060	COG2255	four-way junction helicase activity
SPYCW_RS03075	COG0632	four-way junction helicase activity
SPYCW_RS03080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SPYCW_RS03085	COG0217	transcriptional regulatory protein
SPYCW_RS03090	COG0393	Putative heavy-metal-binding
SPYCW_RS03095	COG3750	Belongs to the UPF0335 family
SPYCW_RS03110	COG0469	pyruvate kinase activity
SPYCW_RS03115	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SPYCW_RS03130	COG0492	ferredoxin-NADP+ reductase activity
SPYCW_RS03160	COG0215	cysteine-tRNA ligase activity
SPYCW_RS03195	COG0271	Belongs to the BolA IbaG family
SPYCW_RS03200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SPYCW_RS03215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPYCW_RS03260	COG2733	membrane
SPYCW_RS03270	COG0308	aminopeptidase N
SPYCW_RS03285	COG1127	ABC transporter
SPYCW_RS03290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SPYCW_RS03305	COG0471	metal ion transport
SPYCW_RS03310	COG1496	oxidoreductase activity
SPYCW_RS03325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPYCW_RS03330	COG0318	PFAM AMP-dependent synthetase and ligase
SPYCW_RS03340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPYCW_RS03350	COG2378	regulation of single-species biofilm formation
SPYCW_RS03365	COG0137	argininosuccinate synthase activity
SPYCW_RS03385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPYCW_RS03415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SPYCW_RS03425	COG3243	poly(R)-hydroxyalkanoic acid synthase
SPYCW_RS03430	COG0436	Aminotransferase
SPYCW_RS03440	COG0154	amidase activity
SPYCW_RS03445	COG2814	Major facilitator Superfamily
SPYCW_RS03455	COG0596	Alpha beta hydrolase
SPYCW_RS03460	COG1522	sequence-specific DNA binding
SPYCW_RS03470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPYCW_RS03485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SPYCW_RS03490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPYCW_RS03495	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SPYCW_RS03505	COG1611	Belongs to the LOG family
SPYCW_RS03510	COG3474	cytochrome
SPYCW_RS03515	COG3474	cytochrome
SPYCW_RS03520	COG0077	Prephenate dehydratase
SPYCW_RS03520	COG1605	Chorismate mutase
SPYCW_RS03540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYCW_RS03540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYCW_RS03560	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SPYCW_RS03570	COG0625	glutathione transferase activity
SPYCW_RS03575	COG1733	regulation of RNA biosynthetic process
SPYCW_RS03590	COG1074	ATP-dependent DNA helicase activity
SPYCW_RS03705	COG0741	lytic transglycosylase activity
SPYCW_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS03725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPYCW_RS03745	COG0583	DNA-binding transcription factor activity
SPYCW_RS03760	COG4962	Type ii secretion system protein e
SPYCW_RS03775	COG3451	type IV secretory pathway VirB4
SPYCW_RS03790	COG3846	protein secretion by the type IV secretion system
SPYCW_RS03795	COG3701	Conjugal transfer protein
SPYCW_RS03825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPYCW_RS03825	COG0519	Catalyzes the synthesis of GMP from XMP
SPYCW_RS03835	COG0438	transferase activity, transferring glycosyl groups
SPYCW_RS03845	COG1012	belongs to the aldehyde dehydrogenase family
SPYCW_RS03850	COG0028	Belongs to the TPP enzyme family
SPYCW_RS03860	COG2852	Protein conserved in bacteria
SPYCW_RS03865	COG2814	Major facilitator Superfamily
SPYCW_RS03895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SPYCW_RS03905	COG1741	Belongs to the pirin family
SPYCW_RS03910	COG0596	Alpha beta hydrolase
SPYCW_RS03915	COG4977	sequence-specific DNA binding
SPYCW_RS03940	COG0259	pyridoxamine-phosphate oxidase activity
SPYCW_RS03945	COG0484	heat shock protein binding
SPYCW_RS03950	COG1295	ribonuclease BN
SPYCW_RS03955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SPYCW_RS03965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SPYCW_RS03970	COG3273	potassium ion transport
SPYCW_RS03970	COG0471	metal ion transport
SPYCW_RS03980	COG1301	dicarboxylic acid transport
SPYCW_RS04000	COG0316	Belongs to the HesB IscA family
SPYCW_RS04005	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYCW_RS04010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYCW_RS04015	COG0719	Fe-S assembly protein
SPYCW_RS04020	COG0396	ATPase activity
SPYCW_RS04035	COG0719	Fe-S assembly protein
SPYCW_RS04055	COG0167	dihydroorotate dehydrogenase activity
SPYCW_RS04060	COG0405	Gamma-glutamyltransferase
SPYCW_RS04065	COG1022	Amp-dependent synthetase and ligase
SPYCW_RS04075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPYCW_RS04120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SPYCW_RS04150	COG4181	ATPase activity
SPYCW_RS04160	COG1742	UPF0060 membrane protein
SPYCW_RS04175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPYCW_RS04220	COG0791	NLP P60 protein
SPYCW_RS04220	COG0741	lytic transglycosylase activity
SPYCW_RS04225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPYCW_RS04240	COG1392	Phosphate transport regulator
SPYCW_RS04245	COG0306	phosphate transporter
SPYCW_RS04255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPYCW_RS04260	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYCW_RS04270	COG2986	histidine ammonia-lyase
SPYCW_RS04275	COG1228	amidohydrolase
SPYCW_RS04335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYCW_RS04340	COG4335	DNA alkylation repair
SPYCW_RS04350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPYCW_RS04370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPYCW_RS04375	COG0250	Participates in transcription elongation, termination and antitermination
SPYCW_RS04380	COG1946	Acyl-CoA thioesterase
SPYCW_RS04385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPYCW_RS04390	COG0081	regulation of translation
SPYCW_RS04395	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPYCW_RS04400	COG4133	protoheme IX ABC transporter activity
SPYCW_RS04410	COG2154	pterin-4-alpha-carbinolamine dehydratase
SPYCW_RS04420	COG0531	amino acid
SPYCW_RS04445	COG3655	Transcriptional regulator
SPYCW_RS04465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPYCW_RS04470	COG0222	ribosome binding
SPYCW_RS04480	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPYCW_RS04490	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SPYCW_RS04495	COG1309	transcriptional regulator
SPYCW_RS04525	COG0741	lytic transglycosylase activity
SPYCW_RS04530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYCW_RS04535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SPYCW_RS04545	COG3590	peptidase
SPYCW_RS04560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPYCW_RS04570	COG0010	Belongs to the arginase family
SPYCW_RS04590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPYCW_RS04625	COG1862	Preprotein translocase
SPYCW_RS04630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPYCW_RS04635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPYCW_RS04640	COG0438	transferase activity, transferring glycosyl groups
SPYCW_RS04655	COG0488	(ABC) transporter
SPYCW_RS04680	COG2832	Protein of unknown function (DUF454)
SPYCW_RS04690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SPYCW_RS04695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SPYCW_RS04700	COG1138	Cytochrome C-type biogenesis protein
SPYCW_RS04705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYCW_RS04710	COG3088	subunit of a heme lyase
SPYCW_RS04715	COG4235	cytochrome complex assembly
SPYCW_RS04720	COG3158	transport of potassium into the cell
SPYCW_RS04760	COG3795	YCII-related domain
SPYCW_RS04765	COG4941	Belongs to the sigma-70 factor family
SPYCW_RS04790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPYCW_RS04795	COG1278	Cold shock
SPYCW_RS04805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPYCW_RS04835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPYCW_RS04840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPYCW_RS04855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPYCW_RS04865	COG0028	Belongs to the TPP enzyme family
SPYCW_RS04870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPYCW_RS04875	COG3830	Belongs to the UPF0237 family
SPYCW_RS04875	COG0560	Phosphoserine phosphatase
SPYCW_RS04930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYCW_RS04935	COG0564	pseudouridine synthase activity
SPYCW_RS04955	COG0643	Histidine kinase
SPYCW_RS04955	COG2198	Histidine kinase
SPYCW_RS04955	COG0784	Response regulator, receiver
SPYCW_RS04970	COG2201	protein-glutamate methylesterase activity
SPYCW_RS04975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SPYCW_RS04980	COG3023	N-Acetylmuramoyl-L-alanine amidase
SPYCW_RS04985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPYCW_RS04990	COG0540	Belongs to the ATCase OTCase family
SPYCW_RS04995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPYCW_RS05005	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SPYCW_RS05010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPYCW_RS05015	COG0154	amidase activity
SPYCW_RS05020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPYCW_RS05045	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPYCW_RS05060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYCW_RS05070	COG1505	serine-type exopeptidase activity
SPYCW_RS05095	COG1131	(ABC) transporter
SPYCW_RS05100	COG0842	Transport permease protein
SPYCW_RS05110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYCW_RS05115	COG0776	regulation of translation
SPYCW_RS05120	COG0539	negative regulation of cytoplasmic translation
SPYCW_RS05125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPYCW_RS05135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SPYCW_RS05170	COG1024	Enoyl-CoA hydratase
SPYCW_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS05180	COG1329	Transcriptional regulator
SPYCW_RS05185	COG0101	tRNA pseudouridine synthase activity
SPYCW_RS05190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPYCW_RS05195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPYCW_RS05200	COG0242	peptide deformylase activity
SPYCW_RS05205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPYCW_RS05210	COG1420	regulation of RNA biosynthetic process
SPYCW_RS05220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SPYCW_RS05225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPYCW_RS05230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYCW_RS05235	COG4974	Belongs to the 'phage' integrase family
SPYCW_RS05240	COG0586	Pfam SNARE associated Golgi protein
SPYCW_RS05245	COG0189	ligase activity
SPYCW_RS05250	COG0792	nuclease activity
SPYCW_RS05255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPYCW_RS05265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPYCW_RS05295	COG3657	addiction module killer protein
SPYCW_RS05300	COG0673	inositol 2-dehydrogenase activity
SPYCW_RS05305	COG0556	nucleotide-excision repair
SPYCW_RS05330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYCW_RS05335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYCW_RS05340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYCW_RS05370	COG0596	Alpha beta hydrolase
SPYCW_RS05370	COG2226	methyltransferase
SPYCW_RS05370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPYCW_RS05390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SPYCW_RS05395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SPYCW_RS05435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPYCW_RS05440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPYCW_RS05445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYCW_RS05450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SPYCW_RS05455	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SPYCW_RS05460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPYCW_RS05475	COG0545	Peptidyl-prolyl cis-trans isomerase
SPYCW_RS05495	COG0642	Histidine kinase
SPYCW_RS05505	COG3268	Saccharopine dehydrogenase
SPYCW_RS05515	COG0717	Belongs to the dCTP deaminase family
SPYCW_RS05520	COG0295	cytidine deaminase activity
SPYCW_RS05530	COG5328	Belongs to the UPF0262 family
SPYCW_RS05535	COG0305	Participates in initiation and elongation during chromosome replication
SPYCW_RS05550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPYCW_RS05565	COG1012	belongs to the aldehyde dehydrogenase family
SPYCW_RS05570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPYCW_RS05575	COG0438	transferase activity, transferring glycosyl groups
SPYCW_RS05585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPYCW_RS05600	COG0183	Belongs to the thiolase family
SPYCW_RS05605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SPYCW_RS05610	COG1012	belongs to the aldehyde dehydrogenase family
SPYCW_RS05615	COG0628	permease
SPYCW_RS05635	COG1595	DNA-templated transcription, initiation
SPYCW_RS05655	COG2957	Belongs to the agmatine deiminase family
SPYCW_RS05670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPYCW_RS05695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYCW_RS05705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPYCW_RS05710	COG0698	ribose 5-phosphate isomerase
SPYCW_RS05715	COG2945	thiolester hydrolase activity
SPYCW_RS05720	COG1104	cysteine desulfurase activity
SPYCW_RS05740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPYCW_RS05750	COG0776	regulation of translation
SPYCW_RS05780	COG0625	glutathione transferase activity
SPYCW_RS05785	COG0287	Prephenate dehydrogenase
SPYCW_RS05785	COG1605	Chorismate mutase
SPYCW_RS05790	COG0142	geranyltranstransferase activity
SPYCW_RS05800	COG1643	Atp-dependent helicase
SPYCW_RS05835	COG0148	phosphopyruvate hydratase activity
SPYCW_RS05845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYCW_RS05850	COG0022	dehydrogenase e1 component
SPYCW_RS05850	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYCW_RS05860	COG1045	serine acetyltransferase
SPYCW_RS05875	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS05880	COG3746	phosphate-selective porin O and P
SPYCW_RS05890	COG0745	RESPONSE REGULATOR receiver
SPYCW_RS05895	COG0704	Plays a role in the regulation of phosphate uptake
SPYCW_RS05900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPYCW_RS05910	COG0573	inorganic phosphate transmembrane transporter activity
SPYCW_RS05935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPYCW_RS05940	COG3590	peptidase
SPYCW_RS05945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPYCW_RS05970	COG3275	phosphorelay sensor kinase activity
SPYCW_RS05975	COG0525	valine-tRNA ligase activity
SPYCW_RS05980	COG0823	Involved in the tonB-independent uptake of proteins
SPYCW_RS05980	COG1506	peptidase
SPYCW_RS05985	COG1228	amidohydrolase
SPYCW_RS05990	COG2321	neutral zinc metallopeptidase
SPYCW_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS06010	COG1473	amidohydrolase
SPYCW_RS06020	COG1024	Enoyl-CoA hydratase
SPYCW_RS06030	COG0861	Integral membrane protein TerC family
SPYCW_RS06055	COG0662	Cupin 2, conserved barrel domain protein
SPYCW_RS06055	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SPYCW_RS06060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPYCW_RS06065	COG4191	Histidine kinase
SPYCW_RS06070	COG2204	response regulator
SPYCW_RS06080	COG2188	Transcriptional regulator
SPYCW_RS06095	COG0402	S-adenosylhomocysteine deaminase activity
SPYCW_RS06115	COG0667	Aldo Keto reductase
SPYCW_RS06125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYCW_RS06130	COG3813	Protein conserved in bacteria
SPYCW_RS06135	COG0351	phosphomethylpyrimidine kinase
SPYCW_RS06135	COG0352	thiamine-phosphate diphosphorylase activity
SPYCW_RS06140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPYCW_RS06145	COG4221	oxidoreductase activity
SPYCW_RS06150	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SPYCW_RS06185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SPYCW_RS06190	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SPYCW_RS06205	COG1794	racemase activity, acting on amino acids and derivatives
SPYCW_RS06260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPYCW_RS06285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPYCW_RS06315	COG0667	Aldo Keto reductase
SPYCW_RS06330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYCW_RS06345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SPYCW_RS06350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPYCW_RS06355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SPYCW_RS06365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SPYCW_RS06370	COG0602	queuosine metabolic process
SPYCW_RS06380	COG0321	lipoyl(octanoyl) transferase activity
SPYCW_RS06395	COG0408	coproporphyrinogen oxidase activity
SPYCW_RS06420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYCW_RS06450	COG1477	protein flavinylation
SPYCW_RS06455	COG3128	pkhd-type hydroxylase
SPYCW_RS06460	COG4774	siderophore transport
SPYCW_RS06470	COG2267	carboxylic ester hydrolase activity
SPYCW_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS06505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SPYCW_RS06555	COG0628	permease
SPYCW_RS06570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPYCW_RS06590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPYCW_RS06595	COG0126	phosphoglycerate kinase activity
SPYCW_RS06600	COG3588	fructose-bisphosphate aldolase
SPYCW_RS06605	COG4122	O-methyltransferase activity
SPYCW_RS06615	COG0352	thiamine-phosphate diphosphorylase activity
SPYCW_RS06620	COG1297	OPT oligopeptide transporter protein
SPYCW_RS06625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPYCW_RS06630	COG0483	inositol monophosphate 1-phosphatase activity
SPYCW_RS06645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPYCW_RS06650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPYCW_RS06655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPYCW_RS06660	COG0649	NAD binding
SPYCW_RS06675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SPYCW_RS06685	COG1034	ATP synthesis coupled electron transport
SPYCW_RS06690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SPYCW_RS06695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SPYCW_RS06705	COG0713	ATP synthesis coupled electron transport
SPYCW_RS06720	COG1007	ATP synthesis coupled electron transport
SPYCW_RS06730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SPYCW_RS06765	COG1522	sequence-specific DNA binding
SPYCW_RS06770	COG2205	protein histidine kinase activity
SPYCW_RS06830	COG0288	reversible hydration of carbon dioxide
SPYCW_RS06835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPYCW_RS06840	COG2867	negative regulation of translational initiation
SPYCW_RS06845	COG1058	Belongs to the CinA family
SPYCW_RS06845	COG1546	Belongs to the CinA family
SPYCW_RS06850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SPYCW_RS06850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPYCW_RS06860	COG3852	Histidine kinase
SPYCW_RS06870	COG5000	phosphorelay sensor kinase activity
SPYCW_RS06875	COG2204	response regulator
SPYCW_RS06880	COG1923	regulation of RNA biosynthetic process
SPYCW_RS06885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYCW_RS06890	COG3956	TIGRFAM MazG family protein
SPYCW_RS06900	COG0084	hydrolase, TatD family'
SPYCW_RS06905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYCW_RS06910	COG0470	DNA polymerase III
SPYCW_RS06915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPYCW_RS06920	COG1686	Belongs to the peptidase S11 family
SPYCW_RS06930	COG2951	lytic endotransglycosylase activity
SPYCW_RS06960	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS06965	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS06970	COG1234	tRNA 3'-trailer cleavage
SPYCW_RS06990	COG0625	glutathione transferase activity
SPYCW_RS06995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPYCW_RS07000	COG0823	Involved in the tonB-independent uptake of proteins
SPYCW_RS07000	COG1506	peptidase
SPYCW_RS07000	COG4946	Tricorn protease homolog
SPYCW_RS07025	COG0842	Transport permease protein
SPYCW_RS07045	COG0187	DNA topoisomerase II activity
SPYCW_RS07070	COG0473	3-isopropylmalate dehydrogenase activity
SPYCW_RS07075	COG1381	Involved in DNA repair and RecF pathway recombination
SPYCW_RS07085	COG0322	excinuclease ABC activity
SPYCW_RS07090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SPYCW_RS07095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SPYCW_RS07100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SPYCW_RS07110	COG0356	it plays a direct role in the translocation of protons across the membrane
SPYCW_RS07135	COG2003	Belongs to the UPF0758 family
SPYCW_RS07150	COG2176	DNA-directed DNA polymerase activity
SPYCW_RS07180	COG1475	DNA binding
SPYCW_RS07215	COG4691	Plasmid stability protein
SPYCW_RS07230	COG5489	Protein of unknown function (DUF736)
SPYCW_RS07280	COG1192	Involved in chromosome partitioning
SPYCW_RS07300	COG5489	Protein of unknown function (DUF736)
SPYCW_RS07305	COG0741	lytic transglycosylase activity
SPYCW_RS07325	COG4962	Type ii secretion system protein e
SPYCW_RS07340	COG3451	type IV secretory pathway VirB4
SPYCW_RS07355	COG3846	protein secretion by the type IV secretion system
SPYCW_RS07370	COG2948	multi-organism process
SPYCW_RS07410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYCW_RS07425	COG1074	ATP-dependent DNA helicase activity
SPYCW_RS07430	COG0556	nucleotide-excision repair
SPYCW_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS07470	COG0625	glutathione transferase activity
SPYCW_RS07475	COG0625	glutathione transferase activity
SPYCW_RS07495	COG1902	pentaerythritol trinitrate reductase activity
SPYCW_RS07500	COG1309	transcriptional regulator
SPYCW_RS07515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS07525	COG0583	DNA-binding transcription factor activity
SPYCW_RS07530	COG3547	Transposase (IS116 IS110 IS902 family)
SPYCW_RS07535	COG0582	viral genome integration into host DNA
SPYCW_RS07615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPYCW_RS07665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS07675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS07680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS07685	COG2076	Multidrug Resistance protein
SPYCW_RS07690	COG3059	membrane
SPYCW_RS07700	COG0251	oxidation-reduction process
SPYCW_RS07705	COG0583	DNA-binding transcription factor activity
SPYCW_RS07715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYCW_RS07720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYCW_RS07745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS07750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYCW_RS07780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYCW_RS07790	COG0284	orotidine-5'-phosphate decarboxylase activity
SPYCW_RS07795	COG0135	phosphoribosylanthranilate isomerase activity
SPYCW_RS07800	COG0133	tryptophan synthase activity
SPYCW_RS07805	COG0159	tryptophan synthase activity
SPYCW_RS07810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPYCW_RS07820	COG2223	nitrite transmembrane transporter activity
SPYCW_RS07825	COG0745	RESPONSE REGULATOR receiver
SPYCW_RS07830	COG1187	pseudouridine synthase activity
SPYCW_RS07835	COG0742	ribosomal rna small subunit methyltransferase
SPYCW_RS07840	COG0477	Major facilitator Superfamily
SPYCW_RS07860	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS07870	COG2130	NADP-dependent
SPYCW_RS07885	COG0277	FAD linked oxidase domain protein
SPYCW_RS07915	COG2211	Major facilitator Superfamily
SPYCW_RS07955	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SPYCW_RS07970	COG0314	molybdopterin synthase activity
SPYCW_RS07980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYCW_RS07995	COG1218	3'(2'),5'-bisphosphate nucleotidase
SPYCW_RS08005	COG0175	sulfate reduction
SPYCW_RS08015	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS08030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPYCW_RS08035	COG2732	(Barnase) inhibitor
SPYCW_RS08040	COG4770	biotin carboxylase activity
SPYCW_RS08045	COG2030	dehydratase
SPYCW_RS08060	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS08065	COG0789	Transcriptional regulator
SPYCW_RS08075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SPYCW_RS08080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPYCW_RS08085	COG4221	oxidoreductase activity
SPYCW_RS08100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SPYCW_RS08105	COG0415	Belongs to the DNA photolyase family
SPYCW_RS08115	COG1013	pyruvate-flavodoxin oxidoreductase activity
SPYCW_RS08120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SPYCW_RS08120	COG0674	pyruvate-flavodoxin oxidoreductase activity
SPYCW_RS08125	COG0657	acetylesterase activity
SPYCW_RS08130	COG1051	belongs to the nudix hydrolase family
SPYCW_RS08135	COG1573	uracil-dna glycosylase
SPYCW_RS08140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPYCW_RS08155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPYCW_RS08160	COG2119	membrane
SPYCW_RS08175	COG0729	surface antigen
SPYCW_RS08185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SPYCW_RS08210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPYCW_RS08220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPYCW_RS08225	COG0438	transferase activity, transferring glycosyl groups
SPYCW_RS08235	COG0438	transferase activity, transferring glycosyl groups
SPYCW_RS08245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPYCW_RS08270	COG3436	PFAM IS66 Orf2 family protein
SPYCW_RS08275	COG4372	Transposase
SPYCW_RS08310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPYCW_RS08315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPYCW_RS08320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SPYCW_RS08325	COG1482	cell wall glycoprotein biosynthetic process
SPYCW_RS08330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SPYCW_RS08335	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SPYCW_RS08350	COG0037	tRNA processing
SPYCW_RS08375	COG1758	RNA polymerase activity
SPYCW_RS08395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYCW_RS08440	COG3436	PFAM IS66 Orf2 family protein
SPYCW_RS08445	COG4372	Transposase
SPYCW_RS08470	COG2323	membrane
SPYCW_RS08490	COG0583	DNA-binding transcription factor activity
SPYCW_RS08505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS08510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYCW_RS08525	COG0662	Cupin 2, conserved barrel domain protein
SPYCW_RS08525	COG2207	Transcriptional regulator
SPYCW_RS08530	COG0783	Belongs to the Dps family
SPYCW_RS08545	COG0625	glutathione transferase activity
SPYCW_RS08550	COG0598	Magnesium transport protein CorA
SPYCW_RS08575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPYCW_RS08695	COG2827	Endonuclease containing a URI domain
SPYCW_RS08720	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS08725	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS08735	COG0183	Belongs to the thiolase family
SPYCW_RS08740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPYCW_RS08745	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS08750	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS08755	COG1024	Enoyl-CoA hydratase
SPYCW_RS08760	COG2365	Tyrosine phosphatase family
SPYCW_RS08765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPYCW_RS08785	COG0671	phosphoesterase, PA-phosphatase related
SPYCW_RS08795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYCW_RS08800	COG2852	Protein conserved in bacteria
SPYCW_RS08805	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYCW_RS08825	COG0557	exoribonuclease II activity
SPYCW_RS08835	COG0442	prolyl-tRNA aminoacylation
SPYCW_RS08860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPYCW_RS08865	COG0477	Major facilitator Superfamily
SPYCW_RS08870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SPYCW_RS08885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYCW_RS08905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPYCW_RS08910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPYCW_RS08910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SPYCW_RS08915	COG0346	lactoylglutathione lyase activity
SPYCW_RS08920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPYCW_RS08925	COG1396	sequence-specific DNA binding
SPYCW_RS08925	COG3800	Transcriptional regulator
SPYCW_RS08935	COG0166	Belongs to the GPI family
SPYCW_RS08940	COG0681	Belongs to the peptidase S26 family
SPYCW_RS08945	COG0571	ribonuclease III activity
SPYCW_RS08950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPYCW_RS08965	COG1754	DNA topoisomerase type I activity
SPYCW_RS08965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYCW_RS08985	COG0758	DNA mediated transformation
SPYCW_RS08995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPYCW_RS09005	COG0156	8-amino-7-oxononanoate synthase activity
SPYCW_RS09020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SPYCW_RS09030	COG1595	DNA-templated transcription, initiation
SPYCW_RS09050	COG1748	Saccharopine dehydrogenase
SPYCW_RS09055	COG0596	Alpha beta hydrolase
SPYCW_RS09085	COG2072	flavoprotein involved in K transport
SPYCW_RS09105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPYCW_RS09120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPYCW_RS09125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SPYCW_RS09125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPYCW_RS09135	COG0129	dihydroxy-acid dehydratase activity
SPYCW_RS09145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPYCW_RS09170	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPYCW_RS09195	COG0386	Belongs to the glutathione peroxidase family
SPYCW_RS09205	COG1136	(ABC) transporter
SPYCW_RS09220	COG0504	CTP synthase activity
SPYCW_RS09230	COG0149	triose-phosphate isomerase activity
SPYCW_RS09240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYCW_RS09245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPYCW_RS09255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SPYCW_RS09260	COG0134	indole-3-glycerol-phosphate synthase activity
SPYCW_RS09265	COG0315	cyclic pyranopterin monophosphate synthase activity
SPYCW_RS09270	COG0303	'Molybdopterin
SPYCW_RS09275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPYCW_RS09280	COG0658	competence protein
SPYCW_RS09280	COG2333	competence protein COMEC
SPYCW_RS09285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPYCW_RS09300	COG5002	protein histidine kinase activity
SPYCW_RS09320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPYCW_RS09330	COG1228	amidohydrolase
SPYCW_RS09350	COG2070	2-Nitropropane dioxygenase
SPYCW_RS09360	COG2239	Acts as a magnesium transporter
SPYCW_RS09365	COG5510	response to toxic substance
SPYCW_RS09370	COG0805	protein transport
SPYCW_RS09375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPYCW_RS09380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPYCW_RS09385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPYCW_RS09390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPYCW_RS09405	COG0018	arginyl-trna synthetase
SPYCW_RS09415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPYCW_RS09420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SPYCW_RS09425	COG0328	RNA-DNA hybrid ribonuclease activity
SPYCW_RS09430	COG3422	double-strand break repair
SPYCW_RS09435	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SPYCW_RS09435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYCW_RS09450	COG4964	Belongs to the GSP D family
SPYCW_RS09485	COG5002	protein histidine kinase activity
SPYCW_RS09490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPYCW_RS09500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYCW_RS09505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPYCW_RS09510	COG0174	glutamine synthetase
SPYCW_RS09525	COG1177	transmembrane transport
SPYCW_RS09540	COG2354	Protein conserved in bacteria
SPYCW_RS09550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPYCW_RS09570	COG0574	Belongs to the PEP-utilizing enzyme family
SPYCW_RS09570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYCW_RS09575	COG0751	glycine-tRNA ligase activity
SPYCW_RS09580	COG0752	glycyl-tRNA synthetase alpha subunit
SPYCW_RS09605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SPYCW_RS09610	COG0193	aminoacyl-tRNA hydrolase activity
SPYCW_RS09615	COG4221	oxidoreductase activity
SPYCW_RS09630	COG0012	GTP binding
SPYCW_RS09640	COG0789	Transcriptional regulator
SPYCW_RS09660	COG3540	Alkaline phosphatase
SPYCW_RS09670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPYCW_RS09690	COG0768	penicillin binding
SPYCW_RS09695	COG0772	Belongs to the SEDS family
SPYCW_RS09765	COG1074	ATP-dependent DNA helicase activity
SPYCW_RS09780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYCW_RS09940	COG4227	nucleotidyltransferase activity
SPYCW_RS09955	COG0071	Belongs to the small heat shock protein (HSP20) family
SPYCW_RS09960	COG0071	Belongs to the small heat shock protein (HSP20) family
SPYCW_RS09985	COG0071	Belongs to the small heat shock protein (HSP20) family
SPYCW_RS10015	COG0783	Belongs to the Dps family
SPYCW_RS10035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SPYCW_RS10040	COG0443	Heat shock 70 kDa protein
SPYCW_RS10050	COG0484	heat shock protein binding
SPYCW_RS10055	COG3118	belongs to the thioredoxin family
SPYCW_RS10095	COG0668	transmembrane transport
SPYCW_RS10130	COG5642	Protein of unknown function (DUF2384)
SPYCW_RS10145	COG0741	lytic transglycosylase activity
SPYCW_RS10145	COG1196	nuclear chromosome segregation
SPYCW_RS10145	COG0739	heme binding
SPYCW_RS10160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYCW_RS10190	COG2010	Cytochrome c
SPYCW_RS10210	COG3047	cAMP biosynthetic process
SPYCW_RS10215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYCW_RS10245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYCW_RS10280	COG1538	Outer membrane efflux protein
SPYCW_RS10285	COG2274	protein secretion by the type I secretion system
SPYCW_RS10295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYCW_RS10320	COG3949	Membrane
SPYCW_RS10340	COG4948	Mandelate Racemase Muconate Lactonizing
SPYCW_RS10345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYCW_RS10355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SPYCW_RS10395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SPYCW_RS10400	COG0109	protoheme IX farnesyltransferase activity
SPYCW_RS10405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SPYCW_RS10410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPYCW_RS10410	COG1565	acr, cog1565
SPYCW_RS10415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPYCW_RS10420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SPYCW_RS10425	COG0736	holo-[acyl-carrier-protein] synthase activity
SPYCW_RS10435	COG0628	permease
SPYCW_RS10440	COG0545	Peptidyl-prolyl cis-trans isomerase
SPYCW_RS10455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SPYCW_RS10460	COG0235	Class ii aldolase
SPYCW_RS10475	COG1228	amidohydrolase
SPYCW_RS10480	COG5001	Diguanylate cyclase
SPYCW_RS10500	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SPYCW_RS10505	COG3321	synthase
SPYCW_RS10505	COG0604	alcohol dehydrogenase
SPYCW_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS10520	COG1199	ATP-dependent helicase activity
SPYCW_RS10525	COG2062	phosphohistidine phosphatase, SixA
SPYCW_RS10535	COG0776	regulation of translation
SPYCW_RS10540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SPYCW_RS10545	COG0416	fatty acid biosynthetic process
SPYCW_RS10550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SPYCW_RS10560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPYCW_RS10580	COG0354	folic acid binding
SPYCW_RS10585	COG0418	dihydroorotase activity
SPYCW_RS10635	COG2022	thiamine diphosphate biosynthetic process
SPYCW_RS10655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SPYCW_RS10665	COG0439	Biotin carboxylase
SPYCW_RS10675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPYCW_RS10680	COG0085	RNA polymerase activity
SPYCW_RS10710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPYCW_RS10720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SPYCW_RS10725	COG0248	Ppx GppA phosphatase
SPYCW_RS10730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPYCW_RS10745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPYCW_RS10750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYCW_RS10755	COG0105	UTP biosynthetic process
SPYCW_RS10770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPYCW_RS10780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPYCW_RS10785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SPYCW_RS10790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPYCW_RS10800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYCW_RS10810	COG1733	regulation of RNA biosynthetic process
SPYCW_RS10825	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SPYCW_RS10830	COG0318	PFAM AMP-dependent synthetase and ligase
SPYCW_RS10840	COG0183	Belongs to the thiolase family
SPYCW_RS10845	COG4771	TonB-dependent receptor
SPYCW_RS10860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYCW_RS10865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SPYCW_RS10875	COG2188	Transcriptional regulator
SPYCW_RS10880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPYCW_RS10885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPYCW_RS10890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYCW_RS10890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYCW_RS10895	COG2190	(PTS) system
SPYCW_RS10895	COG1263	PTS System
SPYCW_RS10895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYCW_RS10900	COG2076	Multidrug Resistance protein
SPYCW_RS10910	COG0697	spore germination
SPYCW_RS10935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPYCW_RS10940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPYCW_RS10950	COG0509	glycine decarboxylation via glycine cleavage system
SPYCW_RS10955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPYCW_RS10965	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SPYCW_RS10980	COG0849	cell division
SPYCW_RS10985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPYCW_RS10990	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPYCW_RS10995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPYCW_RS11005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPYCW_RS11010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPYCW_RS11020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPYCW_RS11025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYCW_RS11030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYCW_RS11035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPYCW_RS11050	COG0275	rRNA processing
SPYCW_RS11055	COG2001	Belongs to the MraZ family
SPYCW_RS11075	COG4771	TonB-dependent receptor
SPYCW_RS11090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYCW_RS11100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPYCW_RS11110	COG0360	Binds together with S18 to 16S ribosomal RNA
SPYCW_RS11115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPYCW_RS11120	COG0359	binds to the 23S rRNA
SPYCW_RS11125	COG0302	gtp cyclohydrolase
SPYCW_RS11150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SPYCW_RS11160	COG0424	maF-like protein
SPYCW_RS11165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPYCW_RS11180	COG0367	asparagine synthase
SPYCW_RS11205	COG3267	Type II secretory pathway component ExeA
SPYCW_RS11205	COG3409	Peptidoglycan-binding domain 1 protein
SPYCW_RS11215	COG0489	protein tyrosine kinase activity
SPYCW_RS11235	COG0318	PFAM AMP-dependent synthetase and ligase
SPYCW_RS11260	COG0492	ferredoxin-NADP+ reductase activity
SPYCW_RS11265	COG2226	methyltransferase
SPYCW_RS11290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SPYCW_RS11315	COG3724	N-succinylarginine dihydrolase activity
SPYCW_RS11340	COG0477	Major facilitator Superfamily
SPYCW_RS11345	COG0513	Belongs to the DEAD box helicase family
SPYCW_RS11355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYCW_RS11360	COG0640	Transcriptional regulator
SPYCW_RS11370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SPYCW_RS11375	COG0254	rRNA binding
SPYCW_RS11380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPYCW_RS11395	COG0750	zinc metalloprotease
SPYCW_RS11400	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPYCW_RS11410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPYCW_RS11415	COG0233	cytoplasmic translational termination
SPYCW_RS11420	COG0528	UMP kinase activity
SPYCW_RS11425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPYCW_RS11430	COG0052	Belongs to the universal ribosomal protein uS2 family
SPYCW_RS11440	COG1183	phosphatidylcholine synthase activity
SPYCW_RS11445	COG0688	phosphatidylethanolamine metabolic process
SPYCW_RS11450	COG0538	isocitrate dehydrogenase activity
SPYCW_RS11460	COG0612	Peptidase, M16
SPYCW_RS11465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPYCW_RS11490	COG3279	Response regulator of the LytR AlgR family
SPYCW_RS11495	COG2972	Histidine kinase
SPYCW_RS11520	COG2205	protein histidine kinase activity
SPYCW_RS11520	COG2198	Histidine kinase
SPYCW_RS11520	COG0784	Response regulator, receiver
SPYCW_RS11530	COG3300	MHYT domain
SPYCW_RS11530	COG5001	Diguanylate cyclase
SPYCW_RS11555	COG3436	PFAM IS66 Orf2 family protein
SPYCW_RS11560	COG4372	Transposase
SPYCW_RS11610	COG3436	PFAM IS66 Orf2 family protein
SPYCW_RS11895	COG4957	zinc ion binding
SPYCW_RS11975	COG0583	DNA-binding transcription factor activity
SPYCW_RS11980	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS12060	COG0582	viral genome integration into host DNA
SPYCW_RS12075	COG1968	undecaprenyl-diphosphatase activity
SPYCW_RS12110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SPYCW_RS12115	COG0527	aspartate kinase activity
SPYCW_RS12130	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SPYCW_RS12135	COG4774	siderophore transport
SPYCW_RS12135	COG1629	transport
SPYCW_RS12145	COG2070	2-Nitropropane dioxygenase
SPYCW_RS12165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYCW_RS12170	COG0297	glycogen (starch) synthase activity
SPYCW_RS12175	COG1253	flavin adenine dinucleotide binding
SPYCW_RS12180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SPYCW_RS12195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SPYCW_RS12205	COG1702	phosphate starvation-inducible protein PhoH
SPYCW_RS12210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPYCW_RS12225	COG4957	zinc ion binding
SPYCW_RS12230	COG1214	PFAM Peptidase M22, glycoprotease
SPYCW_RS12230	COG0456	acetyltransferase
SPYCW_RS12245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SPYCW_RS12265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SPYCW_RS12270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SPYCW_RS12275	COG2080	2 iron, 2 sulfur cluster binding
SPYCW_RS12295	COG1970	mechanosensitive ion channel activity
SPYCW_RS12325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPYCW_RS12340	COG0505	Belongs to the CarA family
SPYCW_RS12350	COG2852	Protein conserved in bacteria
SPYCW_RS12355	COG0358	DNA primase activity
SPYCW_RS12360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYCW_RS12375	COG0542	response to heat
SPYCW_RS12410	COG3739	integral membrane protein
SPYCW_RS12415	COG0006	proline dipeptidase activity
SPYCW_RS12420	COG3876	Protein conserved in bacteria
SPYCW_RS12430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SPYCW_RS12450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYCW_RS12460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPYCW_RS12465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SPYCW_RS12475	COG0582	viral genome integration into host DNA
SPYCW_RS12500	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SPYCW_RS12505	COG0732	type I restriction modification DNA specificity domain
SPYCW_RS12510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYCW_RS12530	COG2003	Belongs to the UPF0758 family
SPYCW_RS12555	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
SPYCW_RS12585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPYCW_RS12590	COG0346	lactoylglutathione lyase activity
SPYCW_RS12600	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPYCW_RS12605	COG0730	response to heat
SPYCW_RS12610	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
SPYCW_RS12630	COG1113	amino acid transport
SPYCW_RS12640	COG1012	belongs to the aldehyde dehydrogenase family
SPYCW_RS12645	COG0028	Belongs to the TPP enzyme family
SPYCW_RS12665	COG4774	siderophore transport
SPYCW_RS12685	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SPYCW_RS12695	COG4771	TonB-dependent receptor
SPYCW_RS12705	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS12710	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS12735	COG1228	amidohydrolase
SPYCW_RS12740	COG1012	belongs to the aldehyde dehydrogenase family
SPYCW_RS12750	COG3158	transport of potassium into the cell
SPYCW_RS12755	COG0745	RESPONSE REGULATOR receiver
SPYCW_RS12770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYCW_RS12785	COG0494	nUDIX hydrolase
SPYCW_RS12805	COG0825	malonyl-CoA metabolic process
SPYCW_RS12810	COG4974	Belongs to the 'phage' integrase family
SPYCW_RS12825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPYCW_RS12850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYCW_RS12855	COG1024	Enoyl-CoA hydratase
SPYCW_RS12870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPYCW_RS12875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYCW_RS12895	COG2308	Evidence 4 Homologs of previously reported genes of
SPYCW_RS12905	COG0653	protein targeting
SPYCW_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS12970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SPYCW_RS12980	COG2081	HI0933 family
SPYCW_RS12995	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SPYCW_RS13015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SPYCW_RS13025	COG1760	l-serine dehydratase
SPYCW_RS13030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPYCW_RS13040	COG1793	dna ligase
SPYCW_RS13040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SPYCW_RS13055	COG2202	Pas domain
SPYCW_RS13055	COG3920	Histidine kinase
SPYCW_RS13060	COG0784	Response regulator, receiver
SPYCW_RS13085	COG2133	pyrroloquinoline quinone binding
SPYCW_RS13090	COG2267	carboxylic ester hydrolase activity
SPYCW_RS13095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPYCW_RS13130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPYCW_RS13135	COG2084	Dehydrogenase
SPYCW_RS13140	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SPYCW_RS13150	COG1304	FMN binding
SPYCW_RS13165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPYCW_RS13180	COG4935	Belongs to the peptidase S8 family
SPYCW_RS13180	COG2234	aminopeptidase activity
SPYCW_RS13190	COG1185	polyribonucleotide nucleotidyltransferase activity
SPYCW_RS13195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SPYCW_RS13200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPYCW_RS13215	COG1435	thymidine kinase activity
SPYCW_RS13250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SPYCW_RS13260	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS13270	COG0009	L-threonylcarbamoyladenylate synthase
SPYCW_RS13275	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS13280	COG3300	MHYT domain
SPYCW_RS13280	COG5001	Diguanylate cyclase
SPYCW_RS13285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYCW_RS13285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYCW_RS13295	COG1372	Participates in initiation and elongation during chromosome replication
SPYCW_RS13295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYCW_RS13345	COG0482	sulfurtransferase activity
SPYCW_RS13380	COG0481	GTPase activity
SPYCW_RS13415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPYCW_RS13415	COG1648	precorrin-2 dehydrogenase activity
SPYCW_RS13420	COG0019	diaminopimelate decarboxylase activity
SPYCW_RS13430	COG0165	Argininosuccinate lyase
SPYCW_RS13435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYCW_RS13445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPYCW_RS13455	COG2267	carboxylic ester hydrolase activity
SPYCW_RS13465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPYCW_RS13470	COG2937	Belongs to the GPAT DAPAT family
SPYCW_RS13480	COG0800	Aldolase
SPYCW_RS13485	COG0129	dihydroxy-acid dehydratase activity
SPYCW_RS13490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPYCW_RS13505	COG0300	oxidoreductase activity
SPYCW_RS13510	COG2207	Transcriptional regulator
SPYCW_RS13515	COG2258	MOSC domain
SPYCW_RS13535	COG0746	molybdenum cofactor guanylyltransferase activity
SPYCW_RS13540	COG0243	molybdopterin cofactor binding
SPYCW_RS13545	COG0642	Histidine kinase
SPYCW_RS13550	COG0745	RESPONSE REGULATOR receiver
SPYCW_RS13565	COG4948	Mandelate Racemase Muconate Lactonizing
SPYCW_RS13580	COG1132	(ABC) transporter
SPYCW_RS13595	COG2885	chlorophyll binding
SPYCW_RS13595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SPYCW_RS13620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPYCW_RS13630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPYCW_RS13645	COG0779	Required for maturation of 30S ribosomal subunits
SPYCW_RS13650	COG1278	Cold shock
SPYCW_RS13685	COG0730	response to heat
SPYCW_RS13700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPYCW_RS13710	COG3483	tryptophan 2,3-dioxygenase activity
SPYCW_RS13715	COG0604	alcohol dehydrogenase
SPYCW_RS13715	COG3321	synthase
SPYCW_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS13730	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYCW_RS13760	COG0045	succinate-CoA ligase (ADP-forming) activity
SPYCW_RS13775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS13795	COG0318	PFAM AMP-dependent synthetase and ligase
SPYCW_RS13820	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SPYCW_RS13820	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SPYCW_RS13855	COG1678	Uncharacterized ACR, COG1678
SPYCW_RS13860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYCW_RS13860	COG0678	peroxiredoxin activity
SPYCW_RS13865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYCW_RS13910	COG1566	PFAM secretion protein HlyD family protein
SPYCW_RS13915	COG2814	Major facilitator Superfamily
SPYCW_RS13945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPYCW_RS13950	COG3738	Protein conserved in bacteria
SPYCW_RS13955	COG0335	large ribosomal subunit rRNA binding
SPYCW_RS13960	COG0336	Belongs to the RNA methyltransferase TrmD family
SPYCW_RS13985	COG3706	GGDEF domain
SPYCW_RS13995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPYCW_RS14000	COG0228	four-way junction DNA binding
SPYCW_RS14005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYCW_RS14010	COG3300	MHYT domain
SPYCW_RS14010	COG5001	Diguanylate cyclase
SPYCW_RS14020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SPYCW_RS14025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPYCW_RS14030	COG0552	protein localization to endoplasmic reticulum
SPYCW_RS14045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SPYCW_RS14060	COG0113	porphobilinogen synthase activity
SPYCW_RS14065	COG0739	heme binding
SPYCW_RS14075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPYCW_RS14080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SPYCW_RS14085	COG0740	serine-type endopeptidase activity
SPYCW_RS14090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SPYCW_RS14140	COG1842	Phage shock protein A
SPYCW_RS14145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SPYCW_RS14150	COG1846	Transcriptional regulator
SPYCW_RS14170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPYCW_RS14175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYCW_RS14210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPYCW_RS14215	COG0745	RESPONSE REGULATOR receiver
SPYCW_RS14220	COG0642	Histidine kinase
SPYCW_RS14225	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPYCW_RS14230	COG1660	Displays ATPase and GTPase activities
SPYCW_RS14245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYCW_RS14255	COG1322	Protein conserved in bacteria
SPYCW_RS14280	COG0443	Heat shock 70 kDa protein
SPYCW_RS14285	COG0484	heat shock protein binding
SPYCW_RS14290	COG1752	Esterase of the alpha-beta hydrolase superfamily
SPYCW_RS14325	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SPYCW_RS14335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPYCW_RS14335	COG2169	Transcriptional regulator
SPYCW_RS14355	COG0412	Dienelactone hydrolase
SPYCW_RS14360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYCW_RS14365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SPYCW_RS14370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPYCW_RS14375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SPYCW_RS14380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SPYCW_RS14405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SPYCW_RS14435	COG5001	Diguanylate cyclase
SPYCW_RS14450	COG4774	siderophore transport
SPYCW_RS14475	COG1217	gtp-binding protein TYPA
SPYCW_RS14485	COG1271	oxidase subunit
SPYCW_RS14490	COG1294	oxidase, subunit
SPYCW_RS14500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYCW_RS14525	COG1585	Membrane protein implicated in regulation of membrane protease activity
SPYCW_RS14530	COG2268	Band 7 protein
SPYCW_RS14585	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS14605	COG1473	amidohydrolase
SPYCW_RS14645	COG0312	modulator of DNA gyrase
SPYCW_RS14680	COG0347	Belongs to the P(II) protein family
SPYCW_RS14685	COG0004	ammonium transporteR
SPYCW_RS14690	COG4771	TonB-dependent receptor
SPYCW_RS14745	COG0514	ATP-dependent DNA helicase (RecQ)
SPYCW_RS14750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SPYCW_RS14750	COG4651	solute:proton antiporter activity
SPYCW_RS14775	COG5265	(ABC) transporter
SPYCW_RS14795	COG1278	Cold shock
SPYCW_RS14800	COG0783	Belongs to the Dps family
SPYCW_RS14825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPYCW_RS14840	COG0196	riboflavin kinase activity
SPYCW_RS14850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPYCW_RS14855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPYCW_RS14880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPYCW_RS14915	COG1942	4-Oxalocrotonate Tautomerase
SPYCW_RS14930	COG2378	regulation of single-species biofilm formation
SPYCW_RS14970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPYCW_RS14975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPYCW_RS15010	COG1764	response to oxidative stress
SPYCW_RS15020	COG1671	Belongs to the UPF0178 family
SPYCW_RS15030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SPYCW_RS15040	COG0140	phosphoribosyl-ATP diphosphatase activity
SPYCW_RS15050	COG2373	Large extracellular alpha-helical protein
SPYCW_RS15055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYCW_RS15060	COG0531	amino acid
SPYCW_RS15065	COG2814	Major facilitator Superfamily
SPYCW_RS15075	COG0612	Peptidase, M16
SPYCW_RS15085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPYCW_RS15090	COG0542	response to heat
SPYCW_RS15110	COG4206	TonB-dependent receptor
SPYCW_RS15125	COG1570	exodeoxyribonuclease VII activity
SPYCW_RS15130	COG0151	Belongs to the GarS family
SPYCW_RS15135	COG3743	rRNA binding
SPYCW_RS15135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SPYCW_RS15145	COG1253	flavin adenine dinucleotide binding
SPYCW_RS15150	COG2885	chlorophyll binding
SPYCW_RS15155	COG2095	MarC family integral membrane protein
SPYCW_RS15165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPYCW_RS15175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SPYCW_RS15185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYCW_RS15200	COG0596	Alpha beta hydrolase
SPYCW_RS15210	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPYCW_RS15215	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SPYCW_RS15220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SPYCW_RS15235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPYCW_RS15255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SPYCW_RS15260	COG0457	Tetratricopeptide repeat
SPYCW_RS15270	COG4771	TonB-dependent receptor
SPYCW_RS15275	COG2205	protein histidine kinase activity
SPYCW_RS15285	COG3178	'Phosphotransferase
SPYCW_RS15290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SPYCW_RS15295	COG2887	Belongs to the helicase family. UvrD subfamily
SPYCW_RS15320	COG0174	glutamine synthetase
SPYCW_RS15330	COG1476	TRANSCRIPTIONal
SPYCW_RS15355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SPYCW_RS15360	COG0024	Methionine aminopeptidase
SPYCW_RS15415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPYCW_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS15430	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS15435	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS15445	COG2211	Major facilitator Superfamily
SPYCW_RS15450	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS15465	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS15470	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS15480	COG1024	Enoyl-CoA hydratase
SPYCW_RS15480	COG1250	3-hydroxyacyl-CoA dehydrogenase
SPYCW_RS15495	COG1024	Enoyl-CoA hydratase
SPYCW_RS15500	COG1024	Enoyl-CoA hydratase
SPYCW_RS15535	COG0583	DNA-binding transcription factor activity
SPYCW_RS15540	COG0246	Mannitol dehydrogenase
SPYCW_RS15545	COG1904	glucuronate isomerase
SPYCW_RS15550	COG2271	Major facilitator Superfamily
SPYCW_RS15560	COG2721	sulfolactate sulfo-lyase activity
SPYCW_RS15565	COG3507	Belongs to the glycosyl hydrolase 43 family
SPYCW_RS15590	COG2272	Belongs to the type-B carboxylesterase lipase family
SPYCW_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS15610	COG1609	Transcriptional regulator
SPYCW_RS15615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYCW_RS15620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPYCW_RS15640	COG0587	DNA-directed DNA polymerase activity
SPYCW_RS15645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SPYCW_RS15650	COG1677	Flagellar hook-basal body complex protein FliE
SPYCW_RS15715	COG1987	bacterial-type flagellum assembly
SPYCW_RS15720	COG1684	flagellar biosynthetic protein fliR
SPYCW_RS15725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SPYCW_RS15745	COG1360	Flagellar Motor Protein
SPYCW_RS15760	COG1256	bacterial-type flagellum assembly
SPYCW_RS15760	COG4786	Flagellar basal body rod
SPYCW_RS15770	COG1706	bacterial-type flagellum-dependent cell motility
SPYCW_RS15775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SPYCW_RS15785	COG4787	bacterial-type flagellum-dependent cell motility
SPYCW_RS15790	COG4786	Flagellar basal body rod
SPYCW_RS15800	COG1558	bacterial-type flagellum-dependent cell motility
SPYCW_RS15865	COG0183	Belongs to the thiolase family
SPYCW_RS15870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SPYCW_RS15875	COG1522	sequence-specific DNA binding
SPYCW_RS15895	COG2855	membrane
SPYCW_RS15905	COG2884	Cell division ATP-binding protein ftsE
SPYCW_RS15925	COG0287	Prephenate dehydrogenase
SPYCW_RS15930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPYCW_RS15935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPYCW_RS15940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPYCW_RS15940	COG2813	Specifically methylates the guanine in position
SPYCW_RS15950	COG1309	transcriptional regulator
SPYCW_RS15955	COG4771	TonB-dependent receptor
SPYCW_RS15965	COG1960	acyl-CoA dehydrogenase activity
SPYCW_RS15980	COG0181	hydroxymethylbilane synthase activity
SPYCW_RS15985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPYCW_RS15990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPYCW_RS16005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPYCW_RS16020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYCW_RS16025	COG4152	abc transporter atp-binding protein
SPYCW_RS16060	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SPYCW_RS16100	COG0357	Ribosomal RNA small subunit methyltransferase G
SPYCW_RS16105	COG0445	tRNA wobble uridine modification
SPYCW_RS16110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPYCW_RS16135	COG0861	Integral membrane protein TerC family
SPYCW_RS16140	COG2329	Antibiotic biosynthesis monooxygenase
SPYCW_RS16145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SPYCW_RS16150	COG1981	membrane
SPYCW_RS16155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPYCW_RS16165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPYCW_RS16170	COG0424	maF-like protein
SPYCW_RS16175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYCW_RS16180	COG0237	dephospho-CoA kinase activity
SPYCW_RS16185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYCW_RS16190	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SPYCW_RS16195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYCW_RS16215	COG2866	Carboxypeptidase
SPYCW_RS16220	COG0454	-acetyltransferase
SPYCW_RS16225	COG0071	Belongs to the small heat shock protein (HSP20) family
SPYCW_RS16230	COG0588	phosphoglycerate mutase activity
SPYCW_RS16240	COG2171	N-acyltransferase activity
SPYCW_RS16250	COG1404	Belongs to the peptidase S8 family
SPYCW_RS16255	COG1228	amidohydrolase
SPYCW_RS16265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPYCW_RS16270	COG0049	tRNA binding
SPYCW_RS16275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPYCW_RS16280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPYCW_RS16285	COG0051	transcription antitermination factor activity, RNA binding
SPYCW_RS16290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPYCW_RS16295	COG0088	Forms part of the polypeptide exit tunnel
SPYCW_RS16300	COG0089	rRNA binding
SPYCW_RS16305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPYCW_RS16310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPYCW_RS16315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPYCW_RS16320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPYCW_RS16325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPYCW_RS16330	COG0255	Belongs to the universal ribosomal protein uL29 family
SPYCW_RS16335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPYCW_RS16340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPYCW_RS16345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SPYCW_RS16350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SPYCW_RS16355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPYCW_RS16360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPYCW_RS16365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPYCW_RS16370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SPYCW_RS16375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPYCW_RS16380	COG1841	ribosomal large subunit assembly
SPYCW_RS16390	COG0200	Binds to the 23S rRNA
SPYCW_RS16395	COG0201	protein transport
SPYCW_RS16400	COG0563	adenylate kinase activity
SPYCW_RS16425	COG0281	malic enzyme
SPYCW_RS16425	COG0280	phosphate acetyltransferase
SPYCW_RS16430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPYCW_RS16435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SPYCW_RS16455	COG0072	phenylalanine-tRNA ligase activity
SPYCW_RS16460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPYCW_RS16470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPYCW_RS16475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPYCW_RS16510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPYCW_RS16520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPYCW_RS16530	COG0784	Response regulator, receiver
SPYCW_RS16560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SPYCW_RS16575	COG1137	ATPase activity
SPYCW_RS16580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SPYCW_RS16585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPYCW_RS16605	COG0006	proline dipeptidase activity
SPYCW_RS16620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPYCW_RS16620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPYCW_RS16635	COG0629	single-stranded DNA binding
SPYCW_RS16660	COG1902	pentaerythritol trinitrate reductase activity
SPYCW_RS16670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPYCW_RS16685	COG1999	signal sequence binding
SPYCW_RS16690	COG2983	Belongs to the UPF0260 family
SPYCW_RS16700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYCW_RS16705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPYCW_RS16710	COG0644	oxidoreductase
SPYCW_RS16755	COG0495	leucyl-tRNA aminoacylation
SPYCW_RS16770	COG4771	TonB-dependent receptor
SPYCW_RS16790	COG1201	RNA secondary structure unwinding
SPYCW_RS16810	COG2066	Belongs to the glutaminase family
SPYCW_RS16825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SPYCW_RS16860	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SPYCW_RS16860	COG0778	Nitroreductase
SPYCW_RS16880	COG0714	Associated with various cellular activities
SPYCW_RS16910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SPYCW_RS16910	COG0546	phosphoglycolate phosphatase activity
SPYCW_RS16920	COG2076	Multidrug Resistance protein
SPYCW_RS16925	COG1228	amidohydrolase
SPYCW_RS16945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYCW_RS16960	COG1136	(ABC) transporter
SPYCW_RS17005	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SPYCW_RS17055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYCW_RS17065	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SPYCW_RS17075	COG1494	fructose-1,6-bisphosphatase
SPYCW_RS17120	COG2032	superoxide dismutase activity
SPYCW_RS17130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYCW_RS17135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SPYCW_RS17140	COG0670	Belongs to the BI1 family
SPYCW_RS17155	COG1546	Belongs to the CinA family
SPYCW_RS17155	COG1058	Belongs to the CinA family
SPYCW_RS17175	COG1522	sequence-specific DNA binding
SPYCW_RS17190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPYCW_RS17225	COG3275	phosphorelay sensor kinase activity
SPYCW_RS17230	COG3279	Response regulator of the LytR AlgR family
SPYCW_RS17250	COG1674	ftsk spoiiie
SPYCW_RS17255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SPYCW_RS17270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SPYCW_RS17275	COG3118	belongs to the thioredoxin family
SPYCW_RS17335	COG1993	acr, cog1993
SPYCW_RS17365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SPYCW_RS17365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPYCW_RS17385	COG0672	)-iron permease
SPYCW_RS17395	COG0789	Transcriptional regulator
SPYCW_RS17420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPYCW_RS17425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYCW_RS17480	COG2226	methyltransferase
SPYCW_RS17510	COG1595	DNA-templated transcription, initiation
SPYCW_RS17550	COG0583	DNA-binding transcription factor activity
SPYCW_RS17555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYCW_RS17560	COG4597	amino acid ABC transporter
SPYCW_RS17565	COG0626	cystathionine gamma-synthase activity
SPYCW_RS17570	COG1126	abc transporter atp-binding protein
SPYCW_RS17600	COG2226	methyltransferase
SPYCW_RS17655	COG1803	Methylglyoxal synthase
SPYCW_RS17655	COG1597	lipid kinase activity
SPYCW_RS17690	COG4221	oxidoreductase activity
SPYCW_RS17695	COG0653	protein targeting
SPYCW_RS17710	COG1196	nuclear chromosome segregation
SPYCW_RS17750	COG4974	Belongs to the 'phage' integrase family
SPYCW_RS17775	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS17795	COG2200	EAL domain
SPYCW_RS17810	COG1538	Outer membrane efflux protein
SPYCW_RS17845	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPYCW_RS17860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYCW_RS17870	COG2771	luxR family
SPYCW_RS17940	COG0823	Involved in the tonB-independent uptake of proteins
SPYCW_RS17940	COG1506	peptidase
SPYCW_RS17965	COG2948	multi-organism process
SPYCW_RS17980	COG3846	protein secretion by the type IV secretion system
SPYCW_RS17995	COG3451	type IV secretory pathway VirB4
SPYCW_RS18010	COG4962	Type ii secretion system protein e
SPYCW_RS18035	COG0741	lytic transglycosylase activity
SPYCW_RS18045	COG4959	Type IV secretory pathway protease TraF
SPYCW_RS18080	COG0583	DNA-binding transcription factor activity
SPYCW_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
SPYCW_RS18125	COG0776	regulation of translation
SPYCW_RS18170	COG0523	cobalamin synthesis protein
SPYCW_RS18285	COG4974	Belongs to the 'phage' integrase family
SPYCW_RS18330	COG0582	viral genome integration into host DNA
SPYCW_RS18335	COG0776	regulation of translation
SPYCW_RS18345	COG1492	cobalamin metabolic process
SPYCW_RS18360	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SPYCW_RS18370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SPYCW_RS18395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SPYCW_RS18400	COG0248	Ppx GppA phosphatase
SPYCW_RS18415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPYCW_RS18420	COG0590	tRNA wobble adenosine to inosine editing
SPYCW_RS18425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPYCW_RS18430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPYCW_RS18440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYCW_RS18445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYCW_RS18455	COG4638	Rieske (2fe-2S)
SPYCW_RS18475	COG0457	Tetratricopeptide repeat
SPYCW_RS18485	COG0501	Belongs to the peptidase M48B family
SPYCW_RS18490	COG1530	ribonuclease E activity
SPYCW_RS18495	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYCW_RS18510	COG1309	transcriptional regulator
SPYCW_RS18515	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SPYCW_RS18525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SPYCW_RS18540	COG0756	dUTP diphosphatase activity
SPYCW_RS18545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYCW_RS18560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SPYCW_RS18565	COG2226	methyltransferase
SPYCW_RS18570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPYCW_RS18575	COG0268	Binds directly to 16S ribosomal RNA
SPYCW_RS18670	COG3093	addiction module antidote protein HigA