locus-tag	class	description
HF685_RS00020	ENOG4105DZP	Membrane-associated zinc metalloprotease
HF685_RS00025	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF685_RS00035	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HF685_RS00040	ENOG41082FS	50S ribosomal protein L31
HF685_RS00045	ENOG4107R7A	Allophanate hydrolase subunit 2
HF685_RS00050	ENOG4105P4J	Allophanate hydrolase, subunit 1
HF685_RS00055	ENOG4105E7W	lamb ycsf family protein
HF685_RS00060	ENOG4105E7W	lamb ycsf family protein
HF685_RS00065	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HF685_RS00080	ENOG4108RTD	type II secretion system protein K
HF685_RS00115	ENOG41060IM	Heme exporter protein
HF685_RS00125	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HF685_RS00130	ENOG4105DA4	cytochrome c-type biogenesis protein
HF685_RS00140	ENOG4105KWW	Biogenesis protein
HF685_RS00150	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HF685_RS00155	ENOG4108YZG	isomerase
HF685_RS00160	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HF685_RS00165	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HF685_RS00220	ENOG4105E50	uracil-dna glycosylase
HF685_RS00245	ENOG4107QX8	SPFH domain, Band 7 family protein
HF685_RS00260	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HF685_RS00270	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HF685_RS00280	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
HF685_RS00285	ENOG4105DQU	oxidoreductase, subunit beta
HF685_RS00300	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HF685_RS00310	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HF685_RS00320	ENOG4105EMU	Dehydrogenase
HF685_RS00325	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HF685_RS00330	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HF685_RS00340	ENOG4108Z6Z	Transcriptional regulator
HF685_RS00345	ENOG4105CSU	acyl-Coa dehydrogenase
HF685_RS00410	ENOG4106H78	methyltransferase
HF685_RS00430	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HF685_RS00435	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HF685_RS00440	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HF685_RS00445	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HF685_RS00450	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HF685_RS00460	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HF685_RS00470	ENOG4105C83	adenylosuccinate lyase
HF685_RS00475	ENOG4105CTQ	phosphohexokinase
HF685_RS00485	ENOG4105W5Q	DNA repair protein (RadC
HF685_RS00510	ENOG4107PQ6	Inherit from NOG: atp synthase
HF685_RS00515	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HF685_RS00520	ENOG4105VD1	ATP synthase subunit C
HF685_RS00525	ENOG4108VHN	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF685_RS00530	ENOG4108733	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF685_RS00535	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HF685_RS00540	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
HF685_RS00545	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HF685_RS00555	ENOG4105NWN	ApaG protein
HF685_RS00570	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF685_RS00580	ENOG4105E3A	(ABC) transporter
HF685_RS00630	ENOG4106TD9	Diguanylate cyclase
HF685_RS00635	ENOG4105ER2	Ompa motb domain protein
HF685_RS00640	ENOG4107RD7	Flagellar Motor Protein, MotA
HF685_RS00660	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HF685_RS00670	ENOG4105CGA	flagellar basal-body rod protein FlgG
HF685_RS00680	ENOG4105CGA	flagellar basal-body rod protein FlgG
HF685_RS00690	ENOG4108ZC9	flagellar basal-body rod protein flgc
HF685_RS00695	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HF685_RS00705	ENOG4105E14	MotA TolQ exbB proton channel
HF685_RS00735	ENOG4105D7B	Flagellar biosynthesis protein flha
HF685_RS00740	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF685_RS00750	ENOG4105I03	Flagellin
HF685_RS00760	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HF685_RS00765	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HF685_RS00770	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HF685_RS00805	ENOG4105DD5	Flagellar motor switch protein
HF685_RS00815	ENOG4105CN7	Flagellar biosynthetic protein FliP
HF685_RS00820	ENOG4105VS8	Flagellar biosynthetic protein fliq
HF685_RS00825	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HF685_RS00830	ENOG4105D00	flagellar biosynthetic protein flhB
HF685_RS00835	ENOG4105DTS	flagellar hook-associated
HF685_RS00865	ENOG4105W5Q	DNA repair protein (RadC
HF685_RS00915	ENOG4105BZU	Histidine kinase
HF685_RS00935	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HF685_RS00955	ENOG4105E5G	Alpha beta hydrolase fold
HF685_RS00965	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HF685_RS00970	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS00975	ENOG4105BZU	Histidine kinase
HF685_RS00980	ENOG4105BZU	Histidine kinase
HF685_RS00985	ENOG4105C26	Dehydrogenase
HF685_RS01000	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HF685_RS01005	ENOG4107R0V	Pyruvate dehydrogenase
HF685_RS01010	ENOG4105CPP	Dehydrogenase, E1 component
HF685_RS01015	ENOG4107QSN	dihydrolipoamide acetyltransferase
HF685_RS01080	ENOG4105BZA	Phosphoglycerate kinase
HF685_RS01085	ENOG4105WYW	fructose-bisphosphate aldolase
HF685_RS01090	ENOG4106HMZ	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HF685_RS01105	ENOG4105ECY	inositol monophosphatase
HF685_RS01110	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF685_RS01115	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF685_RS01120	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF685_RS01125	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF685_RS01140	ENOG4107QIZ	NADH dehydrogenase
HF685_RS01155	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HF685_RS01160	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF685_RS01165	ENOG4105DF2	NADH dehydrogenase subunit j
HF685_RS01170	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF685_RS01175	ENOG4105D65	subunit l
HF685_RS01180	ENOG4105C8S	subunit m
HF685_RS01185	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF685_RS01190	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HF685_RS01195	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HF685_RS01235	ENOG4105BZN	citrate synthase
HF685_RS01240	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HF685_RS01245	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HF685_RS01250	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HF685_RS01255	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HF685_RS01260	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HF685_RS01265	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HF685_RS01270	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HF685_RS01275	ENOG4105DDQ	anthranilate synthase
HF685_RS01285	ENOG4105CRQ	synthase (Component I)
HF685_RS01295	ENOG4105CP7	Triose-phosphate isomerase
HF685_RS01300	ENOG4107Z7P	Ferredoxin
HF685_RS01305	ENOG4106A3M	Cytochrome p-450
HF685_RS01315	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HF685_RS01320	ENOG4105IJJ	transcriptional regulator, crp fnr family
HF685_RS01325	ENOG4108ZNX	Heat shock protein
HF685_RS01330	ENOG4105D60	lipoprotein releasing system transmembrane protein
HF685_RS01335	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HF685_RS01340	ENOG4108V06	Glutathione peroxidase
HF685_RS01360	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HF685_RS01365	ENOG4105I8F	Histidine kinase
HF685_RS01370	ENOG4105K8N	protein family UPF0079, ATPase
HF685_RS01375	ENOG4105EHM	Aminoglycoside phosphotransferase
HF685_RS01380	ENOG4108S0S	Nucleotidyl transferase
HF685_RS01390	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HF685_RS01400	ENOG4108MWI	inositol mono-phosphatase
HF685_RS01420	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HF685_RS01495	ENOG4105C7K	acetolactate synthase
HF685_RS01540	ENOG4105F8J	Adenylate Guanylate cyclase
HF685_RS01560	ENOG4108JQC	penicillin-binding protein 1A
HF685_RS01610	ENOG4107XZX	Involved in the transcription termination process (By similarity)
HF685_RS01620	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HF685_RS01625	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HF685_RS01645	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HF685_RS01670	ENOG4105CB5	ATP-dependent DNA helicase recG
HF685_RS01680	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HF685_RS01690	ENOG4105EHZ	conserved protein UCP016719
HF685_RS01715	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF685_RS01720	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HF685_RS01750	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HF685_RS01795	ENOG4108JYK	Dehydrogenase
HF685_RS01830	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HF685_RS01855	ENOG4105D1Q	UPF0246 protein
HF685_RS01865	ENOG4105F7P	transcriptional regulator AsnC family
HF685_RS01870	ENOG4105BZU	Histidine kinase
HF685_RS01910	ENOG4105C5H	ABC transporter
HF685_RS01925	ENOG4105CK7	Sodium proline symporter
HF685_RS01935	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HF685_RS01955	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HF685_RS01960	ENOG4108Z1B	Cyclase dehydrase
HF685_RS01975	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HF685_RS01985	ENOG4105CUX	Signal transduction histidine kinase
HF685_RS01990	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HF685_RS01995	ENOG4105ES5	Histidine kinase
HF685_RS02000	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HF685_RS02005	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HF685_RS02010	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HF685_RS02015	ENOG4105DXN	mazG family
HF685_RS02020	ENOG4107XAN	XdhC and CoxI family
HF685_RS02035	ENOG4105F8V	Hydrolase, tatD family
HF685_RS02045	ENOG4107QRG	dna polymerase iii
HF685_RS02050	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HF685_RS02055	ENOG4105DZ1	carboxypeptidase
HF685_RS02065	ENOG4105CVE	Lytic murein transglycosylase
HF685_RS02075	ENOG4105DFP	Integrase
HF685_RS02095	ENOG4108UUM	single-stranded DNA-binding protein
HF685_RS02100	ENOG4105CEY	Amp-dependent synthetase and ligase
HF685_RS02130	ENOG4105C85	amino acid
HF685_RS02145	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
HF685_RS02155	ENOG4107RGD	Major Facilitator superfamily
HF685_RS02180	ENOG4105DIA	mandelate racemase muconate lactonizing
HF685_RS02195	ENOG4107RGH	Aldehyde dehydrogenase
HF685_RS02200	ENOG4107RGH	Aldehyde dehydrogenase
HF685_RS02235	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HF685_RS02245	ENOG4105EHG	Permease protein
HF685_RS02250	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HF685_RS02260	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HF685_RS02270	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HF685_RS02285	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HF685_RS02295	ENOG4108NVM	synthesis repressor PhaR
HF685_RS02300	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HF685_RS02305	ENOG4105CSH	Transporter
HF685_RS02320	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HF685_RS02330	ENOG4108K3A	Glutathione S-transferase
HF685_RS02335	ENOG4108UKI	Enoyl-CoA hydratase
HF685_RS02345	ENOG4105CKW	Inner membrane protein yedI
HF685_RS02360	ENOG4107QX3	carboxylase
HF685_RS02365	ENOG4105DC8	reductase
HF685_RS02370	ENOG4107QP8	phosphohexose isomerase
HF685_RS02375	ENOG4105C3F	Signal peptidase i
HF685_RS02385	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HF685_RS02395	ENOG4105C79	DNA protecting protein DprA
HF685_RS02400	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HF685_RS02405	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HF685_RS02410	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HF685_RS02415	ENOG4107T0X	DNA ligase
HF685_RS02430	ENOG4105E3Q	saccharopine dehydrogenase
HF685_RS02475	ENOG4105C01	Dihydroxy-acid dehydratase
HF685_RS02495	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HF685_RS02505	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HF685_RS02510	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HF685_RS02515	ENOG4108UJU	UPF0301 protein
HF685_RS02520	ENOG4105EHV	domain protein
HF685_RS02555	ENOG4105UYK	outer membrane protein a
HF685_RS02560	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HF685_RS02565	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HF685_RS02570	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HF685_RS02590	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HF685_RS02595	ENOG4105K5M	30s ribosomal protein S16
HF685_RS02605	ENOG4105BZU	Histidine kinase
HF685_RS02610	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HF685_RS02615	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF685_RS02620	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HF685_RS02630	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HF685_RS02640	ENOG4105E51	psp operon transcriptional activator
HF685_RS02650	ENOG41087YS	Phage shock protein A
HF685_RS02695	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HF685_RS02700	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HF685_RS02705	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF685_RS02720	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HF685_RS02750	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HF685_RS02755	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HF685_RS02760	ENOG4108S10	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HF685_RS02765	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HF685_RS02780	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF685_RS02790	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HF685_RS02795	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF685_RS02805	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HF685_RS02810	ENOG4105CXT	aspartate transcarbamylase
HF685_RS02815	ENOG4105CD3	dihydroorotase
HF685_RS02840	ENOG4105EAC	phosphoserine phosphatase
HF685_RS02845	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HF685_RS02850	ENOG4105C7K	acetolactate synthase
HF685_RS02865	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HF685_RS02870	ENOG4108YYC	ycei family
HF685_RS02885	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HF685_RS02900	ENOG4105HHA	aminodeoxychorismate lyase
HF685_RS02905	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HF685_RS02910	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HF685_RS02925	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HF685_RS02935	ENOG4105C1G	acyl-Coa dehydrogenase
HF685_RS02950	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HF685_RS02955	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HF685_RS02960	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HF685_RS02975	ENOG4105EUJ	GTP cyclohydrolase i
HF685_RS02985	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HF685_RS02990	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HF685_RS02995	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HF685_RS03000	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HF685_RS03005	ENOG4108J2R	molybdopterin oxidoreductase
HF685_RS03030	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HF685_RS03035	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HF685_RS03040	ENOG4105C3G	gtp-binding protein
HF685_RS03050	ENOG4105DJG	MaoC domain protein dehydratase
HF685_RS03060	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HF685_RS03070	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HF685_RS03080	ENOG4105CJN	penicillin-binding protein
HF685_RS03085	ENOG4105CNI	cell division protein FtsW
HF685_RS03095	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HF685_RS03115	ENOG4105K70	DNA-binding protein
HF685_RS03120	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HF685_RS03130	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HF685_RS03155	ENOG4107QI6	Cysteine desulfurase
HF685_RS03160	ENOG4105DHZ	alpha beta
HF685_RS03175	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HF685_RS03180	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HF685_RS03185	ENOG4105EB3	Histidine kinase
HF685_RS03190	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HF685_RS03195	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HF685_RS03200	ENOG4105DAS	pts system
HF685_RS03210	ENOG4108RWN	rrna methyltransferase
HF685_RS03225	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HF685_RS03230	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HF685_RS03240	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HF685_RS03245	ENOG4105CAQ	asparagine synthetase
HF685_RS03325	ENOG4105C3M	thioredoxin reductase
HF685_RS03375	ENOG4105JJR	Histidine kinase
HF685_RS03400	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HF685_RS03405	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HF685_RS03410	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF685_RS03415	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF685_RS03420	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF685_RS03425	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HF685_RS03430	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HF685_RS03445	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HF685_RS03455	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HF685_RS03460	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HF685_RS03475	ENOG4105DBV	ornithine carbamoyltransferase
HF685_RS03480	ENOG4105C8Y	Acetylornithine aminotransferase
HF685_RS03520	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HF685_RS03545	ENOG4105BZU	Histidine kinase
HF685_RS03555	ENOG4105C8U	phosphate abc transporter
HF685_RS03560	ENOG4105E2Z	phosphate ABC transporter (Permease
HF685_RS03565	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HF685_RS03575	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF685_RS03580	ENOG4106MAR	Phosphate-selective porin O and P
HF685_RS03590	ENOG4105D7W	serine acetyltransferase
HF685_RS03595	ENOG4105C5Q	Transcriptional regulator
HF685_RS03600	ENOG4108ZAF	Molybdopterin
HF685_RS03605	ENOG4105M00	molybdopterin converting factor, subunit 1
HF685_RS03635	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HF685_RS03675	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HF685_RS03685	ENOG41090R7	Ferric uptake
HF685_RS03695	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF685_RS03700	ENOG4105C9A	Phoh family
HF685_RS03705	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HF685_RS03710	ENOG4107RCQ	(CBS) domain
HF685_RS03715	ENOG4108RPX	mosc domain containing protein
HF685_RS03720	ENOG4105CPK	Glycosyl transferase (Group 1
HF685_RS03730	ENOG4105D1H	recombination factor protein RarA
HF685_RS03770	ENOG4105D05	Receptor
HF685_RS03825	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HF685_RS03830	ENOG4105VJY	transcriptional regulator
HF685_RS03870	ENOG4105FAW	cDP-glucose 4,6-dehydratase
HF685_RS03875	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
HF685_RS03890	ENOG4105CHR	reductase
HF685_RS03910	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HF685_RS03915	ENOG4105CHU	acetyl-coa acetyltransferase
HF685_RS03930	ENOG4105BZU	Histidine kinase
HF685_RS03940	ENOG4105I4A	GCN5-related N-acetyltransferase
HF685_RS03950	ENOG4105E2K	Glycosyl transferase (Group 1
HF685_RS03960	ENOG4105CNG	UPF0061 protein
HF685_RS03965	ENOG4105C26	Dehydrogenase
HF685_RS03970	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HF685_RS03980	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HF685_RS03990	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HF685_RS04010	ENOG4105DHP	deoxycytidine triphosphate deaminase
HF685_RS04015	ENOG4105EG6	Saccharopine dehydrogenase
HF685_RS04020	ENOG4107S1Q	Phosphatase
HF685_RS04030	ENOG4108YZN	class I peptide chain release factor
HF685_RS04075	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HF685_RS04085	ENOG4105EFZ	amidohydrolase
HF685_RS04090	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HF685_RS04095	ENOG4105C7B	Threonine dehydratase
HF685_RS04100	ENOG4105BZU	Histidine kinase
HF685_RS04105	ENOG4105EEI	dihydropteroate synthase
HF685_RS04110	ENOG4105CEC	DNA methylase N-4 N-6
HF685_RS04115	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF685_RS04135	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HF685_RS04140	ENOG4105CK2	sodium dicarboxylate symporter
HF685_RS04145	ENOG4108FN7	Aldo keto reductase
HF685_RS04150	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HF685_RS04160	ENOG4105DUX	Transporter
HF685_RS04170	ENOG4105FDP	GntR family transcriptional regulator
HF685_RS04180	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HF685_RS04195	ENOG4105CFF	transcriptional regulator
HF685_RS04210	ENOG4105CH2	amidohydrolase
HF685_RS04220	ENOG4105CGZ	zinc metallopeptidase
HF685_RS04225	ENOG4105CT7	inner membrane cred family protein
HF685_RS04230	ENOG4105DMF	Dehydrogenase
HF685_RS04245	ENOG410829K	Lysine exporter protein (Lyse ygga)
HF685_RS04250	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HF685_RS04260	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
HF685_RS04265	ENOG4105CHR	reductase
HF685_RS04275	ENOG4105CPN	adenine deaminase
HF685_RS04275	ENOG4105CPN	adenine deaminase
HF685_RS04280	ENOG4105DJB	Major Facilitator Superfamily
HF685_RS04285	ENOG4105C5H	ABC transporter
HF685_RS04290	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HF685_RS04295	ENOG4105MIR	Phenylalanine 4-monooxygenase
HF685_RS04320	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF685_RS04325	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF685_RS04330	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HF685_RS04350	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF685_RS04365	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HF685_RS04370	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HF685_RS04375	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HF685_RS04390	ENOG4107104	thymidine kinase
HF685_RS04395	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HF685_RS04415	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HF685_RS04425	ENOG4105CDH	Citrulline--aspartate ligase
HF685_RS04435	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HF685_RS04440	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HF685_RS04455	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HF685_RS04480	ENOG4105NVB	glycoside hydrolase, family 19
HF685_RS04495	ENOG4105D74	hydrolase
HF685_RS04505	ENOG4105EQH	reductase
HF685_RS04530	ENOG4105CC9	acyl-Coa dehydrogenase
HF685_RS04535	ENOG4105D2B	acyl-CoA dehydrogenase
HF685_RS04545	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HF685_RS04560	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HF685_RS04575	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HF685_RS04585	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HF685_RS04590	ENOG4108JQC	penicillin-binding protein 1A
HF685_RS04595	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HF685_RS04600	ENOG4105C03	ribonuclease
HF685_RS04620	ENOG4107R33	ppx gppa phosphatase
HF685_RS04680	ENOG4108I0Y	(ABC) transporter
HF685_RS04695	ENOG4105CI3	gtp-binding protein typa
HF685_RS04700	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HF685_RS04705	ENOG4105KAF	membrAne
HF685_RS04720	ENOG4105EMU	Dehydrogenase
HF685_RS04725	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS04755	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HF685_RS04770	ENOG4108MUZ	hydrolase
HF685_RS04785	ENOG4105VEQ	Cold shock protein
HF685_RS04805	ENOG4107RET	Isocitrate lyase
HF685_RS04835	ENOG4106TD9	Diguanylate cyclase
HF685_RS04840	ENOG4108UQ8	endoribonuclease L-psp
HF685_RS04855	ENOG4105VUH	addiction module killer protein
HF685_RS04870	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HF685_RS04880	ENOG4107R5W	Monooxygenase
HF685_RS04900	ENOG4107RMN	lycopene cyclase
HF685_RS04910	ENOG4105FE1	phytoene synthase
HF685_RS04915	ENOG4105ECY	inositol monophosphatase
HF685_RS04920	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HF685_RS04930	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF685_RS04945	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HF685_RS04955	ENOG4108RM3	Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo
HF685_RS04960	ENOG4105EZE	Cupin 4 family protein
HF685_RS04965	ENOG4107S2E	monooxygenase
HF685_RS04970	ENOG4105D05	Receptor
HF685_RS04980	ENOG4105J0Q	Transcriptional regulator
HF685_RS04995	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS05005	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HF685_RS05010	ENOG4105DG6	mannose-6-phosphate isomerase
HF685_RS05035	ENOG4105CI0	Citrate lyase
HF685_RS05040	ENOG4107RGH	Aldehyde dehydrogenase
HF685_RS05050	ENOG4105C1J	atp-dependent rna helicase
HF685_RS05055	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HF685_RS05060	ENOG4105C4W	S-formylglutathione hydrolase
HF685_RS05070	ENOG4107QPD	alcohol dehydrogenase
HF685_RS05080	ENOG4105T0Z	Conserved Protein
HF685_RS05085	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HF685_RS05095	ENOG4107RUZ	Sss sodium solute transporter superfamily
HF685_RS05110	ENOG4105J5T	Amp-dependent synthetase and ligase
HF685_RS05120	ENOG4108URH	decarboxylase
HF685_RS05125	ENOG4105D9N	nucleoside
HF685_RS05135	ENOG4105DBI	uridine monophosphokinase
HF685_RS05155	ENOG4105DHJ	ABC, transporter
HF685_RS05170	ENOG4105C28	cystathionine
HF685_RS05180	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HF685_RS05185	ENOG4105CD8	aminopeptidase N
HF685_RS05190	ENOG4105D0M	Protease HtpX homolog
HF685_RS05200	ENOG4108594	Permease of the drug metabolite transporter
HF685_RS05205	ENOG4105C5W	Aldolase
HF685_RS05210	ENOG4108R99	pseudouridine synthase
HF685_RS05240	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF685_RS05260	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
HF685_RS05275	ENOG4105CGU	Enoyl-CoA hydratase
HF685_RS05280	ENOG4105EFZ	amidohydrolase
HF685_RS05285	ENOG410846T	CoA-transferase family III
HF685_RS05290	ENOG4107F3J	Amp-dependent synthetase and ligase
HF685_RS05325	ENOG4105CHR	reductase
HF685_RS05330	ENOG4108QIU	Dehydrogenase
HF685_RS05350	ENOG4108ZB6	transcriptional regulator AsnC family
HF685_RS05385	ENOG4105DTD	Dehydrogenase
HF685_RS05400	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HF685_RS05410	ENOG4105CHR	reductase
HF685_RS05415	ENOG4105CHR	reductase
HF685_RS05420	ENOG4105DAB	fumarate reductase succinate dehydrogenase flavoprotein domain protein
HF685_RS05425	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HF685_RS05455	ENOG4107ZSV	Receptor
HF685_RS05505	ENOG4107YFT	Nadph-dependent fmn reductase
HF685_RS05510	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
HF685_RS05535	ENOG4105CHR	reductase
HF685_RS05540	ENOG4105H37	Glyoxalase Bleomycin resistance protein (Dioxygenase
HF685_RS05560	ENOG4105EA8	2-Nitropropane dioxygenase
HF685_RS05565	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS05570	ENOG4105X7H	acyl-CoA dehydrogenase
HF685_RS05575	ENOG4105D2B	acyl-CoA dehydrogenase
HF685_RS05580	ENOG4105CHU	acetyl-coa acetyltransferase
HF685_RS05595	ENOG4105D2B	acyl-CoA dehydrogenase
HF685_RS05600	ENOG4105CC9	acyl-Coa dehydrogenase
HF685_RS05605	ENOG4105CHR	reductase
HF685_RS05615	ENOG4105X1P	Steroid delta-isomerase
HF685_RS05620	ENOG4105CEY	Amp-dependent synthetase and ligase
HF685_RS05650	ENOG4105ENH	Sulfatase
HF685_RS05675	ENOG4105K59	histidine triad (HIT) protein
HF685_RS05680	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
HF685_RS05695	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HF685_RS05700	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HF685_RS05710	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HF685_RS05720	ENOG4105C9Q	fumarate hydratase class II
HF685_RS05730	ENOG4105EGS	Mechanosensitive ion channel
HF685_RS05745	ENOG4105DSF	transport protein
HF685_RS05750	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HF685_RS05795	ENOG4105CPC	Aldo Keto reductase
HF685_RS05815	ENOG4108UPT	UPF0178 protein
HF685_RS05825	ENOG4105CBX	hi0933 family
HF685_RS05830	ENOG4105CC9	acyl-Coa dehydrogenase
HF685_RS05845	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HF685_RS05855	ENOG4105CAT	Cytidine monophosphate kinase
HF685_RS05860	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HF685_RS05865	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF685_RS05880	ENOG4107QSI	ABC, transporter
HF685_RS05885	ENOG4105DIB	Oligopeptide-binding protein
HF685_RS05900	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HF685_RS05915	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HF685_RS05920	ENOG4105CEY	Amp-dependent synthetase and ligase
HF685_RS05940	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HF685_RS05950	ENOG4105NA0	Transcriptional regulator
HF685_RS05980	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HF685_RS05990	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HF685_RS06020	ENOG4108K3A	Glutathione S-transferase
HF685_RS06035	ENOG4107VAM	peptidase, m28
HF685_RS06045	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HF685_RS06050	ENOG4105C1G	acyl-Coa dehydrogenase
HF685_RS06055	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HF685_RS06060	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HF685_RS06065	ENOG4108IQE	Amp-dependent synthetase and ligase
HF685_RS06075	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HF685_RS06115	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HF685_RS06135	ENOG4105C22	threonyL-tRNA synthetase
HF685_RS06145	ENOG4107U7B	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HF685_RS06165	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HF685_RS06175	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF685_RS06205	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HF685_RS06220	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
HF685_RS06225	ENOG4105DFP	Integrase
HF685_RS06245	ENOG4107T5V	SNARE associated Golgi
HF685_RS06270	ENOG4105VW4	glutaredoxin 3
HF685_RS06285	ENOG4105M6F	mutator MutT protein
HF685_RS06305	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HF685_RS06310	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF685_RS06325	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HF685_RS06335	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HF685_RS06360	ENOG4108XC3	NADH ubiquinone oxidoreductase
HF685_RS06380	ENOG4105D9P	serine threonine protein kinase
HF685_RS06400	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HF685_RS06405	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HF685_RS06415	ENOG4105CFG	Acts as a chaperone (By similarity)
HF685_RS06430	ENOG4107QI1	Mate efflux family protein
HF685_RS06440	ENOG4105CY2	Citrate transporter
HF685_RS06455	ENOG4105E2A	Dehydrogenase
HF685_RS06470	ENOG4105C5X	domain protein
HF685_RS06475	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF685_RS06480	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HF685_RS06485	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HF685_RS06505	ENOG4105CSA	Coproporphyrinogen iii oxidase
HF685_RS06510	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF685_RS06515	ENOG4105VC4	domain protein
HF685_RS06525	ENOG4105D7Z	glutathione synthase
HF685_RS06530	ENOG41082FP	UPF0102 protein
HF685_RS06535	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HF685_RS06540	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HF685_RS06545	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HF685_RS06555	ENOG4105C25	Primosomal protein n'
HF685_RS06580	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HF685_RS06585	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF685_RS06590	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HF685_RS06595	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HF685_RS06600	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HF685_RS06605	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HF685_RS06625	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HF685_RS06630	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS06635	ENOG4105CGU	Enoyl-CoA hydratase
HF685_RS06640	ENOG4105C1G	acyl-Coa dehydrogenase
HF685_RS06660	ENOG4105C26	Dehydrogenase
HF685_RS06680	ENOG4105VPX	protein, conserved in bacteria
HF685_RS06685	ENOG4105E3B	Multicopper oxidase
HF685_RS06710	ENOG4105C09	Bile acid
HF685_RS06715	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF685_RS06720	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF685_RS06725	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HF685_RS06730	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HF685_RS06735	ENOG4105K4T	epimerase
HF685_RS06755	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HF685_RS06760	ENOG4108UFP	Essential cell division protein (By similarity)
HF685_RS06765	ENOG4105CPF	Cell wall formation (By similarity)
HF685_RS06770	ENOG4105D4A	Cell wall formation (By similarity)
HF685_RS06775	ENOG4105DFU	Cell wall formation (By similarity)
HF685_RS06780	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HF685_RS06790	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HF685_RS06795	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HF685_RS06820	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HF685_RS06840	ENOG4105C6T	cysteine synthase
HF685_RS06850	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS06885	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
HF685_RS06895	ENOG4107ENK	receptor
HF685_RS06905	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HF685_RS06910	ENOG41081BE	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HF685_RS06915	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HF685_RS06920	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HF685_RS06925	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HF685_RS06940	ENOG4105C75	arginyL-tRNA synthetase
HF685_RS06950	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HF685_RS06960	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF685_RS06965	ENOG4106178	UPF0339 protein
HF685_RS06970	ENOG4105FC8	fad dependent oxidoreductase
HF685_RS07025	ENOG4108RXX	maleylacetoacetate isomerase
HF685_RS07035	ENOG4108Z03	MAF-like protein
HF685_RS07040	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HF685_RS07085	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF685_RS07090	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF685_RS07095	ENOG4105CHR	reductase
HF685_RS07100	ENOG4108NRW	Phospholipase, patatin family
HF685_RS07105	ENOG4107GFK	fumarate
HF685_RS07140	ENOG4108JJ7	ABC transporter
HF685_RS07145	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HF685_RS07175	ENOG4105BZU	Histidine kinase
HF685_RS07180	ENOG4108YZA	Nitrogen regulatory protein pii
HF685_RS07185	ENOG4105D78	K07001 NTE family protein
HF685_RS07210	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HF685_RS07245	ENOG4105DA5	(ABC) transporter
HF685_RS07250	ENOG4108IYU	L-aspartate oxidase
HF685_RS07260	ENOG4107SQI	penicillin amidase
HF685_RS07265	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HF685_RS07285	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HF685_RS07295	ENOG4108K5P	(LipO)protein
HF685_RS07305	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HF685_RS07315	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HF685_RS07345	ENOG4105CP2	von willebrand factor, type a
HF685_RS07355	ENOG41080PD	NADH ubiquinone oxidoreductase 41 kD complex I subunit
HF685_RS07365	ENOG4108ZG0	Ompa motb domain protein
HF685_RS07370	ENOG4105CHR	reductase
HF685_RS07380	ENOG4105CNU	cell division protein FtsK
HF685_RS07395	ENOG4107QJN	gtp cyclohydrolase ii
HF685_RS07405	ENOG4108UUM	single-stranded DNA-binding protein
HF685_RS07410	ENOG4105CE1	Ferrous iron transport protein b
HF685_RS07425	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF685_RS07480	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HF685_RS07485	ENOG4105DZQ	phospholipase D Transphosphatidylase
HF685_RS07505	ENOG4105KBH	arsR family transcriptional regulator
HF685_RS07510	ENOG4105SYT	Methylenetetrahydrofolate reductase
HF685_RS07515	ENOG4105C3R	Methionine synthase
HF685_RS07520	ENOG4105C3R	Methionine synthase
HF685_RS07585	ENOG4105CH2	amidohydrolase
HF685_RS07595	ENOG4107YD3	Thioesterase
HF685_RS07600	ENOG4105E02	MotA TolQ exbB proton channel
HF685_RS07605	ENOG4105SG9	biopolymer transport protein, ExbD
HF685_RS07615	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HF685_RS07620	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HF685_RS07635	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HF685_RS07650	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF685_RS07655	ENOG4105F04	LysR family Transcriptional regulator
HF685_RS07660	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HF685_RS07685	ENOG4105CJW	magnesium transporter
HF685_RS07720	ENOG4105CEN	a g-specific adenine glycosylase
HF685_RS07755	ENOG4108Z4X	TRANSCRIPTIONal
HF685_RS07775	ENOG4105CHR	reductase
HF685_RS07780	ENOG4105C1G	acyl-Coa dehydrogenase
HF685_RS07785	ENOG4105CC9	acyl-Coa dehydrogenase
HF685_RS07800	ENOG4105CC9	acyl-Coa dehydrogenase
HF685_RS07815	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HF685_RS07840	ENOG4108ZT0	50S ribosomal protein l17
HF685_RS07845	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF685_RS07855	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF685_RS07870	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HF685_RS07875	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HF685_RS07890	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HF685_RS07895	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HF685_RS07900	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HF685_RS07905	ENOG41084HQ	50S ribosomal protein L30
HF685_RS07910	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HF685_RS07915	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HF685_RS07920	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HF685_RS07925	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HF685_RS07930	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HF685_RS07935	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HF685_RS07940	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HF685_RS07945	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HF685_RS07950	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HF685_RS07960	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HF685_RS07965	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HF685_RS07970	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HF685_RS07975	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HF685_RS07980	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF685_RS07985	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HF685_RS07990	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HF685_RS07995	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HF685_RS08000	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HF685_RS08005	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF685_RS08010	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HF685_RS08015	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HF685_RS08020	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HF685_RS08055	ENOG41065KQ	synthase
HF685_RS08080	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HF685_RS08115	ENOG4105PGM	cation diffusion facilitator family transporter
HF685_RS08125	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HF685_RS08135	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HF685_RS08145	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
HF685_RS08150	ENOG4105D2B	acyl-CoA dehydrogenase
HF685_RS08160	ENOG4105CI2	imidazolone-5-propionate hydrolase
HF685_RS08180	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HF685_RS08200	ENOG4108D7R	p-hydroxycinnamoyl CoA hydratase lyase
HF685_RS08255	ENOG4105DNH	Major Facilitator
HF685_RS08265	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS08315	ENOG4105CHM	Aminotransferase
HF685_RS08345	ENOG4108J2R	molybdopterin oxidoreductase
HF685_RS08370	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
HF685_RS08375	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF685_RS08380	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HF685_RS08415	ENOG4108UKI	Enoyl-CoA hydratase
HF685_RS08470	ENOG4105CGK	Exodeoxyribonuclease III
HF685_RS08475	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HF685_RS08480	ENOG4105DR5	peptidase
HF685_RS08485	ENOG4105ED9	Protein of unknown function (DUF455)
HF685_RS08490	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF685_RS08495	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HF685_RS08505	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HF685_RS08520	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HF685_RS08530	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HF685_RS08560	ENOG4105EMU	Dehydrogenase
HF685_RS08565	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HF685_RS08585	ENOG4105DHF	Membrane
HF685_RS08595	ENOG4108UQY	Iron-storage protein
HF685_RS08605	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HF685_RS08620	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HF685_RS08630	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HF685_RS08640	ENOG4105S2T	inner membrane protein YbcI
HF685_RS08645	ENOG4105KUZ	arsenate reductase
HF685_RS08660	ENOG4108R6G	acetyltransferase
HF685_RS08700	ENOG4105CEY	Amp-dependent synthetase and ligase
HF685_RS08770	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HF685_RS08780	ENOG4105D8V	Glucose sorbosone dehydrogenase
HF685_RS08805	ENOG4105P8F	nudix hydrolase
HF685_RS08810	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HF685_RS08820	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF685_RS08850	ENOG4107QPR	SAICAR synthetase
HF685_RS08865	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
HF685_RS08870	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HF685_RS08880	ENOG4105UYK	outer membrane protein a
HF685_RS08935	ENOG4105BZG	amino acid carrier protein
HF685_RS08940	ENOG4108UM1	dedA family
HF685_RS08950	ENOG4107ZSV	Receptor
HF685_RS08965	ENOG4105C2C	drug resistance transporter, Bcr CflA
HF685_RS08995	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HF685_RS09000	ENOG4105W8H	transhydrogenase (subunit alpha
HF685_RS09010	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HF685_RS09035	ENOG4105C1J	atp-dependent rna helicase
HF685_RS09080	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HF685_RS09085	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HF685_RS09090	ENOG41082R8	50S ribosomal protein l32
HF685_RS09110	ENOG4105C5X	domain protein
HF685_RS09135	ENOG4105CPK	Glycosyl transferase (Group 1
HF685_RS09150	ENOG4107S8C	mandelate racemase muconate lactonizing
HF685_RS09165	ENOG4105CHU	acetyl-coa acetyltransferase
HF685_RS09170	ENOG4105D64	Mechanosensitive ion channel
HF685_RS09175	ENOG4105DX0	Hemolysin A
HF685_RS09190	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HF685_RS09205	ENOG4105CH7	arginosuccinase
HF685_RS09210	ENOG4107ZT5	Thiol disulfide interchange protein
HF685_RS09220	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HF685_RS09235	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HF685_RS09240	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HF685_RS09250	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HF685_RS09270	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HF685_RS09275	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HF685_RS09300	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HF685_RS09325	ENOG4105CSM	endonuclease III
HF685_RS09410	ENOG4108QDE	fad dependent oxidoreductase
HF685_RS09425	ENOG4105K6V	RNA polymerase
HF685_RS09455	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HF685_RS09475	ENOG41073TP	transcriptional regulator
HF685_RS09485	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HF685_RS09490	ENOG4105C1G	acyl-Coa dehydrogenase
HF685_RS09495	ENOG4105DJG	MaoC domain protein dehydratase
HF685_RS09520	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HF685_RS09535	ENOG4105DNH	Major Facilitator
HF685_RS09550	ENOG4108I5G	Major Facilitator superfamily
HF685_RS09560	ENOG4105CC9	acyl-Coa dehydrogenase
HF685_RS09580	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HF685_RS09625	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
HF685_RS09635	ENOG4108IUW	ABC transporter
HF685_RS09645	ENOG4105DAB	fumarate reductase succinate dehydrogenase flavoprotein domain protein
HF685_RS09690	ENOG4105C7I	Dehydrogenase
HF685_RS09695	ENOG4106BRA	Membrane
HF685_RS09705	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HF685_RS09725	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HF685_RS09740	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HF685_RS09745	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HF685_RS09755	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF685_RS09760	ENOG4107U9T	Pfam:Ribonuclease_BN
HF685_RS09765	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HF685_RS09775	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HF685_RS09795	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HF685_RS09800	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
HF685_RS09860	ENOG4105C2M	dna polymerase I
HF685_RS09865	ENOG4105BZU	Histidine kinase
HF685_RS09900	ENOG4105EQ0	Major Facilitator superfamily
HF685_RS09905	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HF685_RS09910	ENOG4105EJQ	L-serine dehydratase
HF685_RS09920	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HF685_RS09925	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HF685_RS09935	ENOG4105E18	UPF0276 protein
HF685_RS09950	ENOG4105NCT	RNA Polymerase
HF685_RS09960	ENOG4105D07	Signal peptide peptidase, SppA
HF685_RS09965	ENOG4105EN6	Membrane
HF685_RS09985	ENOG4105C7S	Dehydrogenase
HF685_RS10005	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HF685_RS10020	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HF685_RS10025	ENOG4105D6Z	AFG1 family ATPase
HF685_RS10055	ENOG4105EBR	Carboxylesterase
HF685_RS10070	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HF685_RS10075	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HF685_RS10090	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HF685_RS10100	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HF685_RS10110	ENOG4105DWY	Agmatine deiminase
HF685_RS10115	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HF685_RS10130	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HF685_RS10135	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HF685_RS10140	ENOG4105CDY	transcriptional regulatory protein
HF685_RS10150	ENOG4105K8R	UPF0145 protein
HF685_RS10160	ENOG4105Y2X	UPF0335 protein
HF685_RS10180	ENOG4105YK5	50S ribosomal protein L36
HF685_RS10235	ENOG4105DCF	alanine dehydrogenase
HF685_RS10250	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF685_RS10255	ENOG4108IUZ	ABC transporter
HF685_RS10300	ENOG4105W0E	50S ribosomal protein L33
HF685_RS10340	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HF685_RS10365	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
HF685_RS10390	ENOG4105F4G	Membrane
HF685_RS10425	ENOG4105C72	UPF0176 protein
HF685_RS10440	ENOG4105DFA	alanine racemase domain protein
HF685_RS10455	ENOG4105TXM	Domain of unknown function (DUF3576)
HF685_RS10460	ENOG4105C8T	Leucyl-tRNA synthetase
HF685_RS10480	ENOG4105E0X	reductase
HF685_RS10485	ENOG4108JQC	penicillin-binding protein 1A
HF685_RS10495	ENOG4108ZZ3	UPF0260 protein
HF685_RS10530	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HF685_RS10535	ENOG4107TNS	sigma 54 modulation protein ribosomal protein S30ea
HF685_RS10540	ENOG4107RZZ	dna polymerase iii epsilon subunit
HF685_RS10545	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HF685_RS10550	ENOG4105E2X	shikimate dehydrogenase
HF685_RS10555	ENOG4108UHJ	MAF-like protein
HF685_RS10560	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HF685_RS10565	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HF685_RS10570	ENOG4108YXA	Membrane
HF685_RS10575	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HF685_RS10580	ENOG4108ZCF	integral membrane protein
HF685_RS10605	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HF685_RS10610	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HF685_RS10615	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
HF685_RS10675	ENOG41060WC	Enoyl-CoA hydratase
HF685_RS10680	ENOG4107QX3	carboxylase
HF685_RS10685	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF685_RS10690	ENOG4105CHU	acetyl-coa acetyltransferase
HF685_RS10695	ENOG4105C1G	acyl-Coa dehydrogenase
HF685_RS10700	ENOG4107YFT	Nadph-dependent fmn reductase
HF685_RS10735	ENOG4108QV3	biosynthesis protein
HF685_RS10740	ENOG4105JEU	Glycosyl transferase, family 2
HF685_RS10765	ENOG4107T8Q	Glycosyl transferase (Group 1
HF685_RS10790	ENOG4105CAK	Cell division ATP-binding protein ftsE
HF685_RS10815	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HF685_RS10825	ENOG4105DWV	Homoserine O-trans-acetylase
HF685_RS10830	ENOG4105VTW	prevent-host-death family
HF685_RS10835	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
HF685_RS10855	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HF685_RS10860	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HF685_RS10865	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HF685_RS10870	ENOG41082BR	50S ribosomal protein L35
HF685_RS10890	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HF685_RS10905	ENOG4105C4K	Nad synthetase
HF685_RS10925	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HF685_RS10960	ENOG4107MV2	Inherit from COG: Hemolysin-type calcium-binding
HF685_RS11015	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HF685_RS11020	ENOG4107QQG	Dehydrogenase
HF685_RS11035	ENOG4105EXC	Acyl-transferase
HF685_RS11055	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HF685_RS11065	ENOG4105C5E	polysaccharide biosynthesis protein
HF685_RS11070	ENOG4108REZ	Imidazole glycerol phosphate synthase
HF685_RS11075	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HF685_RS11090	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HF685_RS11115	ENOG4105D75	Capsular exopolysaccharide family
HF685_RS11120	ENOG4107YJ4	chain length determinant protein
HF685_RS11165	ENOG4105EMN	RNA polymerase sigma factor
HF685_RS11200	ENOG4107QN1	sodium solute
HF685_RS11235	ENOG4105C3K	feS assembly ATPase SufC
HF685_RS11245	ENOG4105JRK	feS assembly protein SufD
HF685_RS11255	ENOG4105VG1	fes assembly suf system protein
HF685_RS11260	ENOG4108Z4V	iron-sulfur cluster assembly
HF685_RS11275	ENOG4105C10	Electron transfer flavoprotein
HF685_RS11280	ENOG4105BZJ	Electron transfer flavoprotein
HF685_RS11290	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HF685_RS11305	ENOG4105F0N	pyrophosphate phospho-hydrolase
HF685_RS11315	ENOG4105CUT	histidyl-tRNA synthetase
HF685_RS11320	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HF685_RS11325	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HF685_RS11335	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
HF685_RS11340	ENOG4105EKE	dihydroorotase
HF685_RS11345	ENOG4105FR1	rard protein
HF685_RS11390	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HF685_RS11395	ENOG4105MP9	class II Aldolase
HF685_RS11400	ENOG4105CFC	Transporter
HF685_RS11405	ENOG4105CHR	reductase
HF685_RS11435	ENOG4105C31	Tryptophanyl-tRNA synthetase
HF685_RS11440	ENOG4105CJR	Integral membrane protein (MviN
HF685_RS11445	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HF685_RS11465	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HF685_RS11475	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HF685_RS11485	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HF685_RS11495	ENOG41084B3	50S ribosomal protein l34
HF685_RS11510	ENOG4105C0P	Mg chelatase subunit ChlI
HF685_RS11525	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HF685_RS11530	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HF685_RS11540	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HF685_RS11550	ENOG4105CN1	protease
HF685_RS11585	ENOG4105EA8	2-Nitropropane dioxygenase
HF685_RS11590	ENOG4105CFH	Aspartokinase
HF685_RS11595	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HF685_RS11645	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HF685_RS11660	ENOG410679B	prophage CP4-57 regulatory protein alpA
HF685_RS11745	ENOG4105CVR	type I restriction-modification system
HF685_RS11755	ENOG4105DZR	Type I site-specific deoxyribonuclease
HF685_RS11765	ENOG4105DFP	Integrase
HF685_RS11820	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HF685_RS11855	ENOG4105DFU	Cell wall formation (By similarity)
HF685_RS11860	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HF685_RS11870	ENOG4108UAU	isochorismatase
HF685_RS11875	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF685_RS11880	ENOG4108UUM	single-stranded DNA-binding protein
HF685_RS11995	ENOG4108K3A	Glutathione S-transferase
HF685_RS12010	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HF685_RS12045	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF685_RS12065	ENOG4105CGP	Urocanate hydratase
HF685_RS12070	ENOG4105C84	Histidine ammonia-lyase
HF685_RS12075	ENOG4105CI2	imidazolone-5-propionate hydrolase
HF685_RS12080	ENOG41088SP	formiminoglutamate hydrolase
HF685_RS12090	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
HF685_RS12100	ENOG4105CC9	acyl-Coa dehydrogenase
HF685_RS12105	ENOG4108KC2	acyl-Coa dehydrogenase
HF685_RS12110	ENOG4106YT9	Enoyl-CoA hydratase
HF685_RS12130	ENOG4105ES4	Nitrilase
HF685_RS12140	ENOG4105CHR	reductase
HF685_RS12145	ENOG4105EA8	2-Nitropropane dioxygenase
HF685_RS12155	ENOG4105X7H	acyl-CoA dehydrogenase
HF685_RS12160	ENOG4105EUZ	Beta-lactamase domain protein
HF685_RS12165	ENOG4105E39	Enoyl-CoA hydratase
HF685_RS12175	ENOG4105X5Z	General secretion pathway protein I
HF685_RS12205	ENOG4105CHU	acetyl-coa acetyltransferase
HF685_RS12235	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HF685_RS12245	ENOG4108XM1	transcriptional regulator AsnC family
HF685_RS12270	ENOG4105DJB	Major Facilitator Superfamily
HF685_RS12305	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HF685_RS12335	ENOG4105CHR	reductase
HF685_RS12370	ENOG4105D0M	Protease HtpX homolog
HF685_RS12375	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HF685_RS12390	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HF685_RS12405	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HF685_RS12415	ENOG4105DTN	riboflavin biosynthesis protein ribF
HF685_RS12420	ENOG4108IGT	Dipeptidase
HF685_RS12430	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HF685_RS12435	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HF685_RS12440	ENOG4105BZU	Histidine kinase
HF685_RS12445	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HF685_RS12460	ENOG4107ZSV	Receptor
HF685_RS12465	ENOG4105C0A	alcohol dehydrogenase
HF685_RS12505	ENOG4105C5F	glutamine synthetase
HF685_RS12510	ENOG4108YZA	Nitrogen regulatory protein pii
HF685_RS12520	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HF685_RS12530	ENOG4105CEV	competence damage-inducible protein
HF685_RS12560	ENOG4105DK7	lysyl-tRNA synthetase
HF685_RS12575	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HF685_RS12590	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF685_RS12605	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HF685_RS12630	ENOG4105E90	ABC transporter
HF685_RS12635	ENOG4108IJ8	ABC transporter
HF685_RS12640	ENOG4105CHR	reductase
HF685_RS12645	ENOG4105KZX	Pterin carbinolamine dehydratase
HF685_RS12690	ENOG4105CD3	dihydroorotase
HF685_RS12700	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HF685_RS12705	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HF685_RS12710	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HF685_RS12715	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HF685_RS12725	ENOG4108NEV	two component transcriptional regulator, LytTR family
HF685_RS12730	ENOG4108HRK	Histidine kinase
HF685_RS12770	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HF685_RS12775	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HF685_RS12795	ENOG4105K46	50S ribosomal protein l27
HF685_RS12800	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HF685_RS12815	ENOG4108Z0R	Transferase
HF685_RS12825	ENOG4105D52	delta-aminolevulinic acid dehydratase
HF685_RS12835	ENOG4105DR5	peptidase
HF685_RS12850	ENOG4108Z4U	Ferredoxin
HF685_RS12855	ENOG4108VJ1	Transcriptional regulator (CarD family
HF685_RS12865	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HF685_RS12895	ENOG4105CSU	acyl-Coa dehydrogenase
HF685_RS12900	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF685_RS12905	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HF685_RS12910	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HF685_RS12915	ENOG4105BZS	acriflavin resistance protein
HF685_RS12920	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HF685_RS12945	ENOG4105CC0	LysR family Transcriptional regulator
HF685_RS12950	ENOG4105C2I	pirin domain protein
HF685_RS12955	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HF685_RS12960	ENOG4107EFQ	arachidonate 15-lipoxygenase
HF685_RS12965	ENOG4105BZU	Histidine kinase
HF685_RS12970	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF685_RS12980	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF685_RS12990	ENOG4105VMP	Transcriptional regulator
HF685_RS13000	ENOG41068WN	
HF685_RS13040	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HF685_RS13055	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HF685_RS13060	ENOG4108VZM	50s ribosomal protein L10
HF685_RS13080	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HF685_RS13095	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HF685_RS13130	ENOG4105WD1	Membrane
HF685_RS13135	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HF685_RS13145	ENOG4105C5Q	Transcriptional regulator
HF685_RS13150	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HF685_RS13175	ENOG4105GB5	regulatory protein RecX
HF685_RS13180	ENOG4107RCI	amp-dependent synthetase and ligase
HF685_RS13190	ENOG4107QJE	Chromosome Partitioning Protein
HF685_RS13195	ENOG4105K89	arsenate reductase
HF685_RS13200	ENOG4108ESX	Receptor
HF685_RS13210	ENOG4105MP9	class II Aldolase
HF685_RS13215	ENOG4105K5G	30S ribosomal protein S21
HF685_RS13225	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HF685_RS13250	ENOG4108HRK	Histidine kinase
HF685_RS13255	ENOG4108NEV	two component transcriptional regulator, LytTR family
HF685_RS13260	ENOG4105KDC	50s ribosomal protein l28
HF685_RS13340	ENOG4108R85	Short chain dehydrogenase
HF685_RS13345	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HF685_RS13360	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HF685_RS13370	ENOG4105CHU	acetyl-coa acetyltransferase
HF685_RS13385	ENOG4105X1P	Steroid delta-isomerase
HF685_RS13390	ENOG4105C1G	acyl-Coa dehydrogenase
HF685_RS13395	ENOG4105D2B	acyl-CoA dehydrogenase
HF685_RS13400	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HF685_RS13415	ENOG4107RUY	(E1 component), alpha subunit
HF685_RS13435	ENOG41060I7	thioesterase Superfamily protein
HF685_RS13445	ENOG4105DVW	rieske (2Fe-2S)
HF685_RS13465	ENOG4105CHR	reductase
HF685_RS13480	ENOG4105CFU	surface antigen
HF685_RS13495	ENOG4107S2Z	UPF0761 membrane protein
HF685_RS13510	ENOG4105EGS	Mechanosensitive ion channel
HF685_RS13520	ENOG4105EMU	Dehydrogenase
HF685_RS13540	ENOG4107ZSV	Receptor
HF685_RS13550	ENOG4107YCY	Transcriptional regulator
HF685_RS13560	ENOG4105EY3	heparinase II III family protein
HF685_RS13570	ENOG4108I5G	Major Facilitator superfamily
HF685_RS13575	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HF685_RS13580	ENOG4108UHU	Aldolase
HF685_RS13595	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HF685_RS13665	ENOG4105NAU	thioesterase Superfamily protein
HF685_RS13720	ENOG4105D44	asparaginase
HF685_RS13735	ENOG4105DGU	Histone deacetylase
HF685_RS13760	ENOG4105DEN	Luciferase family
HF685_RS13765	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HF685_RS13775	ENOG4105CUB	amino acid
HF685_RS13785	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HF685_RS13805	ENOG4105E0X	reductase
HF685_RS13815	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HF685_RS13830	ENOG4107RUZ	Sss sodium solute transporter superfamily
HF685_RS13855	ENOG4108S01	response regulator
HF685_RS13865	ENOG4108IUX	(ABC) transporter
HF685_RS13870	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HF685_RS13900	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HF685_RS13910	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HF685_RS13935	ENOG4105DC7	peptidase M24
HF685_RS13940	ENOG4107YD3	Thioesterase
HF685_RS13955	ENOG4105CYC	Transferase
HF685_RS13965	ENOG4108IUZ	ABC transporter
HF685_RS13980	ENOG4107QX3	carboxylase
HF685_RS14000	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF685_RS14005	ENOG4105CEY	Amp-dependent synthetase and ligase
HF685_RS14010	ENOG4105C29	acyl-CoA thioesterase
HF685_RS14015	ENOG4105CHU	acetyl-coa acetyltransferase
HF685_RS14030	ENOG4105W5Q	DNA repair protein (RadC
HF685_RS14060	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HF685_RS14070	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HF685_RS14085	ENOG4105CHR	reductase
HF685_RS14090	ENOG4105ETE	Transcriptional regulator (LacI family
HF685_RS14140	ENOG4105DHF	Membrane
HF685_RS14160	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HF685_RS14180	ENOG4105D8X	mechanosensitive ion channel
HF685_RS14200	ENOG41074H6	response regulator
HF685_RS14220	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HF685_RS14240	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
HF685_RS14250	ENOG4105CSH	Transporter
HF685_RS14255	ENOG4105E2S	oxidase) subunit II
HF685_RS14260	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HF685_RS14265	ENOG4105CCU	oxidase (Subunit III)
HF685_RS14270	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HF685_RS14280	ENOG4105TX3	Histidine kinase
HF685_RS14285	ENOG4108UYB	regulatoR
HF685_RS14300	ENOG4107T65	Integrase
HF685_RS14305	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF685_RS14310	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HF685_RS14330	ENOG41076YT	nitrate reductase, gamma subunit
HF685_RS14335	ENOG4105R3A	Nitrate reductase
HF685_RS14340	ENOG4108IUE	nitrate reductase beta subunit
HF685_RS14345	ENOG4105CRU	nitrate reductase, alpha subunit
HF685_RS14350	ENOG4105DQQ	Major facilitator superfamily MFS_1
HF685_RS14365	ENOG4108UUM	single-stranded DNA-binding protein
HF685_RS14425	ENOG4108UUM	single-stranded DNA-binding protein
HF685_RS14440	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HF685_RS14460	ENOG4105CBT	Fructose-1,6-bisphosphatase
HF685_RS14470	ENOG4105D6E	homoserine dehydrogenase
HF685_RS14490	ENOG4105M8F	Biopolymer transport protein exbD tolR
HF685_RS14500	ENOG4105BZ1	(ABC) transporter
HF685_RS14520	ENOG4105II7	pyrroline-5-carboxylate reductase
HF685_RS14525	ENOG41090HR	transcriptional regulator
HF685_RS14530	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HF685_RS14540	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF685_RS14550	ENOG4105C08	Histidine kinase
HF685_RS14565	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HF685_RS14585	ENOG4105C2F	Histidine kinase
HF685_RS14590	ENOG4105DY9	regulatoR
HF685_RS14595	ENOG410846T	CoA-transferase family III
HF685_RS14620	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HF685_RS14625	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HF685_RS14640	ENOG4105EYW	Ion transport protein
HF685_RS14655	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HF685_RS14660	ENOG4105BZU	Histidine kinase
HF685_RS14665	ENOG4105CT3	Monooxygenase
HF685_RS14670	ENOG4105CT3	Monooxygenase
HF685_RS14675	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HF685_RS14680	ENOG4107SN7	NLP P60 protein
HF685_RS14695	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HF685_RS14705	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HF685_RS14715	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HF685_RS14720	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HF685_RS14730	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HF685_RS14735	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HF685_RS14750	ENOG4105D98	threonine synthase
HF685_RS14765	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HF685_RS14795	ENOG4105C7K	acetolactate synthase
HF685_RS14820	ENOG4105GVR	general secretion pathway protein D
HF685_RS14830	ENOG4105D7Q	type ii secretion system
HF685_RS14835	ENOG4108VAU	general secretion pathway protein G
HF685_RS14905	ENOG4105D9P	serine threonine protein kinase
HF685_RS14915	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HF685_RS14950	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HF685_RS14955	ENOG41067HS	methyltransferase
HF685_RS14960	ENOG4108PVD	exported protein
HF685_RS14965	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF685_RS14970	ENOG4105CIR	epoxide hydrolase
HF685_RS14980	ENOG4108Z6Z	Transcriptional regulator
HF685_RS14985	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HF685_RS14990	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HF685_RS14995	ENOG4108JQ5	ABC transporter
HF685_RS15010	ENOG4105D64	Mechanosensitive ion channel
HF685_RS15015	ENOG4105C28	cystathionine
HF685_RS15020	ENOG4105KHC	sulfurtransferase
HF685_RS15025	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HF685_RS15040	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HF685_RS15060	ENOG4105D7A	ATP-binding protein
HF685_RS15080	ENOG4105D1F	ATP-binding protein
HF685_RS15085	ENOG4105K4P	CoA-binding domain protein
HF685_RS15095	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HF685_RS15110	ENOG41085J0	Protein CrcB homolog
HF685_RS15115	ENOG4105EI2	Pseudouridine synthase
HF685_RS15125	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HF685_RS15145	ENOG4105FYV	Amp nucleosidase
HF685_RS15160	ENOG4107QN2	dihydrolipoyl dehydrogenase
HF685_RS15180	ENOG4105DGW	oligopeptidase A
HF685_RS15185	ENOG4105BZS	acriflavin resistance protein
HF685_RS15210	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF685_RS15230	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HF685_RS15235	ENOG4105CEY	Amp-dependent synthetase and ligase
HF685_RS15240	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HF685_RS15260	ENOG4105C6K	Malic enzyme
HF685_RS15265	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HF685_RS15270	ENOG4105CAS	nag kinase
HF685_RS15280	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HF685_RS15290	ENOG41081FY	multiple antibiotic resistance (MarC)-related
HF685_RS15295	ENOG4105W49	UPF0434 protein
HF685_RS15300	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HF685_RS15305	ENOG4105K63	Thioredoxin
HF685_RS15340	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF685_RS15355	ENOG41089UC	methyltransferase, type 11
HF685_RS15360	ENOG41082SX	arsR family transcriptional regulator
HF685_RS15365	ENOG4105D3R	alkyl hydroperoxide reductase
HF685_RS15380	ENOG4105KFG	YeeE YedE family protein
HF685_RS15385	ENOG4105C01	Dihydroxy-acid dehydratase
HF685_RS15410	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HF685_RS15415	ENOG4105KJF	protein tyrosine phosphatase
HF685_RS15420	ENOG4105HFZ	Membrane
HF685_RS15465	ENOG4105CEY	Amp-dependent synthetase and ligase
HF685_RS15525	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HF685_RS15565	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HF685_RS15570	ENOG4105BZU	Histidine kinase
HF685_RS15595	ENOG4105CY0	Metallo-Beta-Lactamase
HF685_RS15640	ENOG4105VIE	preprotein translocase, subunit YajC
HF685_RS15650	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HF685_RS15660	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HF685_RS15680	ENOG4105C5H	ABC transporter
HF685_RS15685	ENOG4105F0I	Aminotransferase
HF685_RS15700	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HF685_RS15705	ENOG4105IFJ	Histidine kinase
HF685_RS15710	ENOG4105BZ8	glutamate synthase
HF685_RS15720	ENOG4105EAH	synthase
HF685_RS15740	ENOG4105HA9	of methanol dehydrogenase type
HF685_RS15745	ENOG4108V0P	LemA family
HF685_RS15750	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HF685_RS15775	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
HF685_RS15780	ENOG4105F4X	arginine
HF685_RS15785	ENOG4105CH2	amidohydrolase
HF685_RS15790	ENOG4107QP3	malate synthase g
HF685_RS15795	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HF685_RS15810	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HF685_RS15815	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HF685_RS15830	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HF685_RS15840	ENOG4105V9V	Short-chain dehydrogenase reductase Sdr
HF685_RS15850	ENOG4105K6V	RNA polymerase
HF685_RS15865	ENOG4105BZU	Histidine kinase
HF685_RS15870	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HF685_RS15875	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HF685_RS15890	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HF685_RS15900	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HF685_RS15915	ENOG4105C9M	aspartyl-trna synthetase
HF685_RS15920	ENOG4108YIQ	Alpha beta hydrolase
HF685_RS15930	ENOG4105CSR	polyphosphate kinase 2
HF685_RS15940	ENOG4105E4C	Lytic transglycosylase catalytic
HF685_RS15945	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HF685_RS15950	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HF685_RS15975	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HF685_RS15980	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HF685_RS16005	ENOG4105CE9	30S ribosomal protein S2
HF685_RS16010	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)