locus-tag	class	description
HF685_RS00015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HF685_RS00020	COG0750	zinc metalloprotease
HF685_RS00025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF685_RS00035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF685_RS00040	COG0254	rRNA binding
HF685_RS00045	COG1984	allophanate hydrolase subunit 2
HF685_RS00050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HF685_RS00055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HF685_RS00060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HF685_RS00115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HF685_RS00125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HF685_RS00130	COG1138	Cytochrome C-type biogenesis protein
HF685_RS00140	COG4235	cytochrome complex assembly
HF685_RS00140	COG3088	subunit of a heme lyase
HF685_RS00150	COG3158	transport of potassium into the cell
HF685_RS00155	COG0698	ribose 5-phosphate isomerase
HF685_RS00160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HF685_RS00165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HF685_RS00180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HF685_RS00220	COG1573	uracil-dna glycosylase
HF685_RS00245	COG0330	HflC and HflK could
HF685_RS00260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HF685_RS00270	COG1051	belongs to the nudix hydrolase family
HF685_RS00280	COG0674	pyruvate-flavodoxin oxidoreductase activity
HF685_RS00280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HF685_RS00285	COG1013	pyruvate-flavodoxin oxidoreductase activity
HF685_RS00300	COG0415	Belongs to the DNA photolyase family
HF685_RS00310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HF685_RS00320	COG4221	oxidoreductase activity
HF685_RS00325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HF685_RS00330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HF685_RS00340	COG0789	Transcriptional regulator
HF685_RS00345	COG1960	acyl-CoA dehydrogenase activity
HF685_RS00410	COG0742	ribosomal rna small subunit methyltransferase
HF685_RS00415	COG1187	pseudouridine synthase activity
HF685_RS00430	COG0285	dihydrofolate synthase activity
HF685_RS00435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HF685_RS00440	COG0159	tryptophan synthase activity
HF685_RS00445	COG0133	tryptophan synthase activity
HF685_RS00450	COG0135	phosphoribosylanthranilate isomerase activity
HF685_RS00460	COG0284	orotidine-5'-phosphate decarboxylase activity
HF685_RS00470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HF685_RS00475	COG0205	6-phosphofructokinase activity
HF685_RS00485	COG2003	Belongs to the UPF0758 family
HF685_RS00515	COG0356	it plays a direct role in the translocation of protons across the membrane
HF685_RS00520	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF685_RS00525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HF685_RS00530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HF685_RS00535	COG0322	excinuclease ABC activity
HF685_RS00540	COG1381	Involved in DNA repair and RecF pathway recombination
HF685_RS00545	COG0473	3-isopropylmalate dehydrogenase activity
HF685_RS00555	COG2967	ApaG domain
HF685_RS00570	COG0187	DNA topoisomerase II activity
HF685_RS00580	COG0842	Transport permease protein
HF685_RS00630	COG3706	GGDEF domain
HF685_RS00635	COG1360	Flagellar Motor Protein
HF685_RS00660	COG1706	bacterial-type flagellum-dependent cell motility
HF685_RS00665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HF685_RS00670	COG4786	Flagellar basal body rod
HF685_RS00690	COG1558	bacterial-type flagellum-dependent cell motility
HF685_RS00695	COG1815	bacterial-type flagellum-dependent cell motility
HF685_RS00705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HF685_RS00740	COG1191	sigma factor activity
HF685_RS00750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HF685_RS00760	COG1677	Flagellar hook-basal body complex protein FliE
HF685_RS00770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HF685_RS00820	COG1987	bacterial-type flagellum assembly
HF685_RS00825	COG1684	flagellar biosynthetic protein fliR
HF685_RS00865	COG2003	Belongs to the UPF0758 family
HF685_RS00915	COG3706	GGDEF domain
HF685_RS00940	COG2937	Belongs to the GPAT DAPAT family
HF685_RS00945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HF685_RS00955	COG2267	carboxylic ester hydrolase activity
HF685_RS00965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HF685_RS00970	COG1024	Enoyl-CoA hydratase
HF685_RS00975	COG0784	Response regulator, receiver
HF685_RS00975	COG2205	protein histidine kinase activity
HF685_RS00975	COG2198	Histidine kinase
HF685_RS00985	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HF685_RS00985	COG0506	proline dehydrogenase activity
HF685_RS00985	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HF685_RS01000	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HF685_RS01075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HF685_RS01080	COG0126	phosphoglycerate kinase activity
HF685_RS01085	COG3588	fructose-bisphosphate aldolase
HF685_RS01090	COG0352	thiamine-phosphate diphosphorylase activity
HF685_RS01100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HF685_RS01105	COG0483	inositol monophosphate 1-phosphatase activity
HF685_RS01110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF685_RS01115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF685_RS01120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF685_RS01125	COG0649	NAD binding
HF685_RS01140	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF685_RS01150	COG1034	ATP synthesis coupled electron transport
HF685_RS01155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HF685_RS01160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF685_RS01170	COG0713	ATP synthesis coupled electron transport
HF685_RS01185	COG1007	ATP synthesis coupled electron transport
HF685_RS01195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HF685_RS01235	COG0372	Belongs to the citrate synthase family
HF685_RS01240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF685_RS01245	COG0658	competence protein
HF685_RS01245	COG2333	competence protein COMEC
HF685_RS01250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HF685_RS01255	COG0303	'Molybdopterin
HF685_RS01265	COG0134	indole-3-glycerol-phosphate synthase activity
HF685_RS01270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HF685_RS01285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HF685_RS01295	COG0149	triose-phosphate isomerase activity
HF685_RS01300	COG0633	Ferredoxin
HF685_RS01305	COG2124	cytochrome p450
HF685_RS01315	COG0504	CTP synthase activity
HF685_RS01320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF685_RS01325	COG0071	Belongs to the small heat shock protein (HSP20) family
HF685_RS01335	COG1136	(ABC) transporter
HF685_RS01340	COG0386	Belongs to the glutathione peroxidase family
HF685_RS01360	COG0521	Mo-molybdopterin cofactor biosynthetic process
HF685_RS01365	COG2205	protein histidine kinase activity
HF685_RS01370	COG0802	atpase or kinase
HF685_RS01375	COG3178	'Phosphotransferase
HF685_RS01380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HF685_RS01390	COG1074	ATP-dependent DNA helicase activity
HF685_RS01395	COG3118	belongs to the thioredoxin family
HF685_RS01400	COG0483	inositol monophosphate 1-phosphatase activity
HF685_RS01410	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HF685_RS01420	COG0653	protein targeting
HF685_RS01490	COG1012	belongs to the aldehyde dehydrogenase family
HF685_RS01560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HF685_RS01595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HF685_RS01600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HF685_RS01610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HF685_RS01620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HF685_RS01625	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HF685_RS01645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HF685_RS01655	COG4251	negative regulation of phosphorylation
HF685_RS01655	COG3706	GGDEF domain
HF685_RS01655	COG2203	Gaf domain
HF685_RS01655	COG5001	Diguanylate cyclase
HF685_RS01660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HF685_RS01670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HF685_RS01680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HF685_RS01690	COG3876	Protein conserved in bacteria
HF685_RS01705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF685_RS01715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HF685_RS01730	COG0505	Belongs to the CarA family
HF685_RS01750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF685_RS01795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HF685_RS01800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF685_RS01800	COG0022	dehydrogenase e1 component
HF685_RS01830	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HF685_RS01845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HF685_RS01855	COG3022	response to hydroperoxide
HF685_RS01865	COG1522	sequence-specific DNA binding
HF685_RS01870	COG2205	protein histidine kinase activity
HF685_RS01910	COG0488	(ABC) transporter
HF685_RS01925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF685_RS01955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HF685_RS01960	COG2867	negative regulation of translational initiation
HF685_RS01975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HF685_RS01975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HF685_RS01985	COG3852	Histidine kinase
HF685_RS01990	COG2204	response regulator
HF685_RS01995	COG5000	phosphorelay sensor kinase activity
HF685_RS02000	COG2204	response regulator
HF685_RS02005	COG1923	regulation of RNA biosynthetic process
HF685_RS02010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HF685_RS02015	COG3956	TIGRFAM MazG family protein
HF685_RS02020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HF685_RS02035	COG0084	hydrolase, TatD family'
HF685_RS02050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HF685_RS02055	COG1686	Belongs to the peptidase S11 family
HF685_RS02065	COG2951	lytic endotransglycosylase activity
HF685_RS02075	COG0582	viral genome integration into host DNA
HF685_RS02095	COG0629	single-stranded DNA binding
HF685_RS02100	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS02130	COG1113	amino acid transport
HF685_RS02155	COG2814	Major facilitator Superfamily
HF685_RS02185	COG2175	clavaminate synthase activity
HF685_RS02190	COG0028	Belongs to the TPP enzyme family
HF685_RS02200	COG1012	belongs to the aldehyde dehydrogenase family
HF685_RS02235	COG4206	TonB-dependent receptor
HF685_RS02245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HF685_RS02250	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HF685_RS02265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF685_RS02270	COG2852	Protein conserved in bacteria
HF685_RS02285	COG0557	exoribonuclease II activity
HF685_RS02295	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HF685_RS02300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HF685_RS02305	COG0477	Major facilitator Superfamily
HF685_RS02310	COG4770	biotin carboxylase activity
HF685_RS02320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HF685_RS02325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF685_RS02325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF685_RS02330	COG0625	glutathione transferase activity
HF685_RS02335	COG1024	Enoyl-CoA hydratase
HF685_RS02345	COG2354	Protein conserved in bacteria
HF685_RS02360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF685_RS02370	COG0166	Belongs to the GPI family
HF685_RS02375	COG0681	Belongs to the peptidase S26 family
HF685_RS02380	COG0571	ribonuclease III activity
HF685_RS02385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HF685_RS02390	COG1754	DNA topoisomerase type I activity
HF685_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF685_RS02395	COG0758	DNA mediated transformation
HF685_RS02400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HF685_RS02405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HF685_RS02410	COG0156	8-amino-7-oxononanoate synthase activity
HF685_RS02415	COG1793	dna ligase
HF685_RS02415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HF685_RS02430	COG1748	Saccharopine dehydrogenase
HF685_RS02460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HF685_RS02465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HF685_RS02465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HF685_RS02475	COG0129	dihydroxy-acid dehydratase activity
HF685_RS02485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HF685_RS02495	COG0644	oxidoreductase
HF685_RS02495	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HF685_RS02505	COG0741	lytic transglycosylase activity
HF685_RS02510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HF685_RS02515	COG1678	Uncharacterized ACR, COG1678
HF685_RS02520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HF685_RS02520	COG0678	peroxiredoxin activity
HF685_RS02560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HF685_RS02565	COG0335	large ribosomal subunit rRNA binding
HF685_RS02570	COG0336	Belongs to the RNA methyltransferase TrmD family
HF685_RS02590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HF685_RS02595	COG0228	four-way junction DNA binding
HF685_RS02600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF685_RS02605	COG5001	Diguanylate cyclase
HF685_RS02605	COG3300	MHYT domain
HF685_RS02610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HF685_RS02615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF685_RS02620	COG0552	protein localization to endoplasmic reticulum
HF685_RS02640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HF685_RS02650	COG1842	Phage shock protein A
HF685_RS02700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF685_RS02700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF685_RS02705	COG0484	heat shock protein binding
HF685_RS02720	COG3023	N-Acetylmuramoyl-L-alanine amidase
HF685_RS02735	COG0564	pseudouridine synthase activity
HF685_RS02750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HF685_RS02755	COG0740	serine-type endopeptidase activity
HF685_RS02760	COG0740	serine-type endopeptidase activity
HF685_RS02765	COG0544	peptidyl-prolyl cis-trans isomerase activity
HF685_RS02780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF685_RS02790	COG0154	amidase activity
HF685_RS02795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF685_RS02805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HF685_RS02810	COG0540	Belongs to the ATCase OTCase family
HF685_RS02815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HF685_RS02840	COG0560	Phosphoserine phosphatase
HF685_RS02845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HF685_RS02850	COG0028	Belongs to the TPP enzyme family
HF685_RS02855	COG0440	acetolactate synthase activity
HF685_RS02865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HF685_RS02870	COG2353	YceI-like domain
HF685_RS02885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF685_RS02900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HF685_RS02905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF685_RS02910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HF685_RS02935	COG1960	acyl-CoA dehydrogenase activity
HF685_RS02950	COG0360	Binds together with S18 to 16S ribosomal RNA
HF685_RS02955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HF685_RS02960	COG0359	binds to the 23S rRNA
HF685_RS02970	COG3128	pkhd-type hydroxylase
HF685_RS02975	COG0302	gtp cyclohydrolase
HF685_RS02985	COG0574	Belongs to the PEP-utilizing enzyme family
HF685_RS02985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HF685_RS02990	COG0751	glycine-tRNA ligase activity
HF685_RS02995	COG0751	glycine-tRNA ligase activity
HF685_RS03000	COG0752	glycyl-tRNA synthetase alpha subunit
HF685_RS03030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HF685_RS03035	COG0193	aminoacyl-tRNA hydrolase activity
HF685_RS03040	COG0012	GTP binding
HF685_RS03050	COG2030	dehydratase
HF685_RS03060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HF685_RS03070	COG1792	Involved in formation and maintenance of cell shape
HF685_RS03080	COG0768	penicillin binding
HF685_RS03085	COG0772	Belongs to the SEDS family
HF685_RS03095	COG4206	TonB-dependent receptor
HF685_RS03115	COG0776	regulation of translation
HF685_RS03125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HF685_RS03155	COG1104	cysteine desulfurase activity
HF685_RS03160	COG2945	thiolester hydrolase activity
HF685_RS03175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HF685_RS03180	COG0745	RESPONSE REGULATOR receiver
HF685_RS03185	COG0642	Histidine kinase
HF685_RS03190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HF685_RS03195	COG1660	Displays ATPase and GTPase activities
HF685_RS03200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HF685_RS03200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HF685_RS03210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF685_RS03220	COG1322	Protein conserved in bacteria
HF685_RS03225	COG0242	peptide deformylase activity
HF685_RS03230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HF685_RS03240	COG0101	tRNA pseudouridine synthase activity
HF685_RS03245	COG0367	asparagine synthase
HF685_RS03270	COG3267	Type II secretory pathway component ExeA
HF685_RS03270	COG3409	Peptidoglycan-binding domain 1 protein
HF685_RS03300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HF685_RS03325	COG0492	ferredoxin-NADP+ reductase activity
HF685_RS03375	COG2205	protein histidine kinase activity
HF685_RS03380	COG0745	RESPONSE REGULATOR receiver
HF685_RS03405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HF685_RS03410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HF685_RS03410	COG2857	Cytochrome c1
HF685_RS03420	COG0723	plastoquinol--plastocyanin reductase activity
HF685_RS03425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HF685_RS03430	COG0408	coproporphyrinogen oxidase activity
HF685_RS03445	COG0321	lipoyl(octanoyl) transferase activity
HF685_RS03455	COG0602	queuosine metabolic process
HF685_RS03460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HF685_RS03475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HF685_RS03480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HF685_RS03485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HF685_RS03500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HF685_RS03520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HF685_RS03545	COG5002	protein histidine kinase activity
HF685_RS03555	COG0573	inorganic phosphate transmembrane transporter activity
HF685_RS03560	COG0581	inorganic phosphate transmembrane transporter activity
HF685_RS03565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HF685_RS03570	COG0704	Plays a role in the regulation of phosphate uptake
HF685_RS03575	COG0745	RESPONSE REGULATOR receiver
HF685_RS03580	COG3746	phosphate-selective porin O and P
HF685_RS03590	COG1045	serine acetyltransferase
HF685_RS03595	COG0583	DNA-binding transcription factor activity
HF685_RS03600	COG0314	molybdopterin synthase activity
HF685_RS03605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HF685_RS03635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HF685_RS03675	COG0456	acetyltransferase
HF685_RS03680	COG4957	zinc ion binding
HF685_RS03695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF685_RS03700	COG1702	phosphate starvation-inducible protein PhoH
HF685_RS03705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HF685_RS03710	COG1253	flavin adenine dinucleotide binding
HF685_RS03715	COG2258	MOSC domain
HF685_RS03720	COG0438	transferase activity, transferring glycosyl groups
HF685_RS03730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HF685_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS03745	COG3321	synthase
HF685_RS03745	COG0604	alcohol dehydrogenase
HF685_RS03750	COG0668	transmembrane transport
HF685_RS03765	COG4771	TonB-dependent receptor
HF685_RS03770	COG4771	TonB-dependent receptor
HF685_RS03825	COG4206	TonB-dependent receptor
HF685_RS03830	COG2771	luxR family
HF685_RS03875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HF685_RS03910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HF685_RS03915	COG0183	Belongs to the thiolase family
HF685_RS03930	COG0004	ammonium transporteR
HF685_RS03940	COG0454	-acetyltransferase
HF685_RS03950	COG0438	transferase activity, transferring glycosyl groups
HF685_RS03960	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HF685_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
HF685_RS03970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HF685_RS03970	COG1648	precorrin-2 dehydrogenase activity
HF685_RS03980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HF685_RS03990	COG0175	sulfate reduction
HF685_RS04010	COG0717	Belongs to the dCTP deaminase family
HF685_RS04015	COG3268	Saccharopine dehydrogenase
HF685_RS04020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HF685_RS04065	COG1956	GAF domain-containing protein
HF685_RS04075	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HF685_RS04085	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HF685_RS04090	COG2084	Dehydrogenase
HF685_RS04095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HF685_RS04100	COG5001	Diguanylate cyclase
HF685_RS04100	COG3300	MHYT domain
HF685_RS04105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HF685_RS04110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HF685_RS04115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HF685_RS04120	COG0351	phosphomethylpyrimidine kinase
HF685_RS04135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HF685_RS04140	COG1301	dicarboxylic acid transport
HF685_RS04145	COG0667	Aldo Keto reductase
HF685_RS04150	COG0402	S-adenosylhomocysteine deaminase activity
HF685_RS04160	COG3104	oligopeptide transport
HF685_RS04170	COG2188	Transcriptional regulator
HF685_RS04180	COG2204	response regulator
HF685_RS04185	COG5002	protein histidine kinase activity
HF685_RS04190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HF685_RS04195	COG1396	sequence-specific DNA binding
HF685_RS04195	COG3800	Transcriptional regulator
HF685_RS04210	COG1473	amidohydrolase
HF685_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS04220	COG2321	neutral zinc metallopeptidase
HF685_RS04225	COG4452	Inner membrane protein CreD
HF685_RS04230	COG1304	FMN binding
HF685_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS04275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HF685_RS04275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HF685_RS04280	COG2271	Major facilitator Superfamily
HF685_RS04285	COG0488	(ABC) transporter
HF685_RS04290	COG2264	protein methyltransferase activity
HF685_RS04295	COG3186	Phenylalanine-4-hydroxylase
HF685_RS04320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF685_RS04325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF685_RS04330	COG2852	Protein conserved in bacteria
HF685_RS04350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF685_RS04365	COG1185	polyribonucleotide nucleotidyltransferase activity
HF685_RS04370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HF685_RS04375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HF685_RS04390	COG1435	thymidine kinase activity
HF685_RS04395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HF685_RS04400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HF685_RS04415	COG0779	Required for maturation of 30S ribosomal subunits
HF685_RS04425	COG0137	argininosuccinate synthase activity
HF685_RS04435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HF685_RS04440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HF685_RS04445	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HF685_RS04455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HF685_RS04480	COG3179	chitinase
HF685_RS04495	COG0596	Alpha beta hydrolase
HF685_RS04505	COG0493	'glutamate synthase
HF685_RS04530	COG1960	acyl-CoA dehydrogenase activity
HF685_RS04535	COG1960	acyl-CoA dehydrogenase activity
HF685_RS04560	COG2814	Major facilitator Superfamily
HF685_RS04575	COG0275	rRNA processing
HF685_RS04590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HF685_RS04595	COG0860	N-Acetylmuramoyl-L-alanine amidase
HF685_RS04600	COG1530	ribonuclease E activity
HF685_RS04620	COG0248	Ppx GppA phosphatase
HF685_RS04660	COG0067	glutamate synthase
HF685_RS04660	COG0069	glutamate synthase activity
HF685_RS04660	COG0070	glutamate synthase
HF685_RS04680	COG4181	ATPase activity
HF685_RS04700	COG1234	tRNA 3'-trailer cleavage
HF685_RS04705	COG3152	Membrane
HF685_RS04720	COG4221	oxidoreductase activity
HF685_RS04725	COG1024	Enoyl-CoA hydratase
HF685_RS04755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HF685_RS04770	COG2267	carboxylic ester hydrolase activity
HF685_RS04785	COG1278	Cold shock
HF685_RS04800	COG2211	Major facilitator Superfamily
HF685_RS04835	COG3706	GGDEF domain
HF685_RS04840	COG0251	oxidation-reduction process
HF685_RS04855	COG3657	addiction module killer protein
HF685_RS04870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HF685_RS04880	COG2072	flavoprotein involved in K transport
HF685_RS04915	COG0483	inositol monophosphate 1-phosphatase activity
HF685_RS04920	COG0312	modulator of DNA gyrase
HF685_RS04930	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF685_RS04930	COG1902	pentaerythritol trinitrate reductase activity
HF685_RS04945	COG0175	sulfate reduction
HF685_RS04955	COG1218	3'(2'),5'-bisphosphate nucleotidase
HF685_RS04960	COG2850	peptidyl-arginine hydroxylation
HF685_RS04965	COG2072	flavoprotein involved in K transport
HF685_RS04970	COG4771	TonB-dependent receptor
HF685_RS04995	COG1024	Enoyl-CoA hydratase
HF685_RS05000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF685_RS05005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HF685_RS05010	COG1482	cell wall glycoprotein biosynthetic process
HF685_RS05035	COG2301	Belongs to the HpcH HpaI aldolase family
HF685_RS05040	COG1012	belongs to the aldehyde dehydrogenase family
HF685_RS05050	COG0513	Belongs to the DEAD box helicase family
HF685_RS05055	COG0405	Gamma-glutamyltransferase
HF685_RS05060	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HF685_RS05070	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HF685_RS05080	COG3214	Protein conserved in bacteria
HF685_RS05085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HF685_RS05095	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF685_RS05110	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS05125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HF685_RS05135	COG0572	uridine kinase
HF685_RS05155	COG1127	ABC transporter
HF685_RS05160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HF685_RS05185	COG0308	aminopeptidase N
HF685_RS05190	COG0501	Belongs to the peptidase M48B family
HF685_RS05200	COG0697	spore germination
HF685_RS05240	COG1902	pentaerythritol trinitrate reductase activity
HF685_RS05260	COG0300	oxidoreductase activity
HF685_RS05275	COG1024	Enoyl-CoA hydratase
HF685_RS05280	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HF685_RS05285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF685_RS05290	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05350	COG1522	sequence-specific DNA binding
HF685_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05385	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05390	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HF685_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05420	COG1053	succinate dehydrogenase
HF685_RS05455	COG4771	TonB-dependent receptor
HF685_RS05505	COG0431	NADPH-dependent FMN reductase
HF685_RS05510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF685_RS05515	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HF685_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05540	COG0346	lactoylglutathione lyase activity
HF685_RS05555	COG1024	Enoyl-CoA hydratase
HF685_RS05565	COG1024	Enoyl-CoA hydratase
HF685_RS05570	COG1960	acyl-CoA dehydrogenase activity
HF685_RS05575	COG1960	acyl-CoA dehydrogenase activity
HF685_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05595	COG1960	acyl-CoA dehydrogenase activity
HF685_RS05600	COG1960	acyl-CoA dehydrogenase activity
HF685_RS05650	COG3119	arylsulfatase activity
HF685_RS05665	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HF685_RS05680	COG0140	phosphoribosyl-ATP diphosphatase activity
HF685_RS05695	COG0107	imidazoleglycerol-phosphate synthase activity
HF685_RS05700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HF685_RS05705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HF685_RS05710	COG0131	Imidazoleglycerol-phosphate dehydratase
HF685_RS05720	COG0114	fumarate hydratase activity
HF685_RS05730	COG3264	Mechanosensitive ion channel
HF685_RS05730	COG1196	nuclear chromosome segregation
HF685_RS05745	COG0628	permease
HF685_RS05750	COG0194	GDP metabolic process
HF685_RS05765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HF685_RS05795	COG0667	Aldo Keto reductase
HF685_RS05815	COG1671	Belongs to the UPF0178 family
HF685_RS05825	COG2081	HI0933 family
HF685_RS05830	COG1960	acyl-CoA dehydrogenase activity
HF685_RS05845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HF685_RS05855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HF685_RS05860	COG0539	negative regulation of cytoplasmic translation
HF685_RS05865	COG0776	regulation of translation
HF685_RS05880	COG4166	transmembrane transport
HF685_RS05885	COG4166	transmembrane transport
HF685_RS05915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HF685_RS05920	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS05940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF685_RS05960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HF685_RS05975	COG3321	synthase
HF685_RS05975	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS05975	COG0604	alcohol dehydrogenase
HF685_RS05980	COG0066	3-isopropylmalate dehydratase activity
HF685_RS05990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HF685_RS06020	COG0625	glutathione transferase activity
HF685_RS06035	COG2234	aminopeptidase activity
HF685_RS06050	COG1960	acyl-CoA dehydrogenase activity
HF685_RS06055	COG0167	dihydroorotate dehydrogenase activity
HF685_RS06060	COG0405	Gamma-glutamyltransferase
HF685_RS06065	COG1022	Amp-dependent synthetase and ligase
HF685_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF685_RS06115	COG0596	Alpha beta hydrolase
HF685_RS06135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HF685_RS06140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HF685_RS06145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HF685_RS06160	COG5001	Diguanylate cyclase
HF685_RS06165	COG2824	Alkylphosphonate utilization operon protein PhnA
HF685_RS06175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF685_RS06185	COG0583	DNA-binding transcription factor activity
HF685_RS06205	COG0823	Involved in the tonB-independent uptake of proteins
HF685_RS06205	COG1506	peptidase
HF685_RS06205	COG4946	Tricorn protease homolog
HF685_RS06220	COG3483	tryptophan 2,3-dioxygenase activity
HF685_RS06225	COG0582	viral genome integration into host DNA
HF685_RS06245	COG0586	Pfam SNARE associated Golgi protein
HF685_RS06265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HF685_RS06270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HF685_RS06285	COG0494	nUDIX hydrolase
HF685_RS06305	COG0825	malonyl-CoA metabolic process
HF685_RS06310	COG4974	Belongs to the 'phage' integrase family
HF685_RS06325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HF685_RS06330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HF685_RS06360	COG3738	Protein conserved in bacteria
HF685_RS06365	COG1752	Esterase of the alpha-beta hydrolase superfamily
HF685_RS06365	COG1752	Esterase of the alpha-beta hydrolase superfamily
HF685_RS06380	COG2815	serine threonine protein kinase
HF685_RS06380	COG0515	serine threonine protein kinase
HF685_RS06400	COG2130	NADP-dependent
HF685_RS06405	COG2130	NADP-dependent
HF685_RS06410	COG0484	heat shock protein binding
HF685_RS06415	COG0443	Heat shock 70 kDa protein
HF685_RS06430	COG0534	Mate efflux family protein
HF685_RS06440	COG2610	gluconate transmembrane transporter activity
HF685_RS06470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF685_RS06475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF685_RS06480	COG1420	regulation of RNA biosynthetic process
HF685_RS06485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HF685_RS06490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HF685_RS06505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HF685_RS06510	COG4974	Belongs to the 'phage' integrase family
HF685_RS06515	COG2827	Endonuclease containing a URI domain
HF685_RS06525	COG0189	ligase activity
HF685_RS06530	COG0792	nuclease activity
HF685_RS06535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HF685_RS06540	COG3107	peptidoglycan biosynthetic process
HF685_RS06545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HF685_RS06580	COG2169	Transcriptional regulator
HF685_RS06580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HF685_RS06585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF685_RS06590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HF685_RS06595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HF685_RS06600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HF685_RS06605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HF685_RS06630	COG1024	Enoyl-CoA hydratase
HF685_RS06635	COG1024	Enoyl-CoA hydratase
HF685_RS06640	COG1960	acyl-CoA dehydrogenase activity
HF685_RS06680	COG1937	Protein conserved in bacteria
HF685_RS06685	COG2132	Multicopper oxidase
HF685_RS06710	COG0385	Bile acid
HF685_RS06715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF685_RS06720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF685_RS06725	COG0509	glycine decarboxylation via glycine cleavage system
HF685_RS06730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HF685_RS06735	COG0702	epimerase
HF685_RS06760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HF685_RS06765	COG1181	Belongs to the D-alanine--D-alanine ligase family
HF685_RS06770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HF685_RS06775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HF685_RS06780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HF685_RS06790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HF685_RS06795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HF685_RS06805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HF685_RS06820	COG0275	rRNA processing
HF685_RS06850	COG1024	Enoyl-CoA hydratase
HF685_RS06885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HF685_RS06895	COG4771	TonB-dependent receptor
HF685_RS06905	COG0805	protein transport
HF685_RS06910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF685_RS06915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF685_RS06920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HF685_RS06925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HF685_RS06940	COG0018	arginyl-trna synthetase
HF685_RS06950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HF685_RS06955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HF685_RS06960	COG0328	RNA-DNA hybrid ribonuclease activity
HF685_RS06965	COG3422	double-strand break repair
HF685_RS06990	COG4964	Belongs to the GSP D family
HF685_RS07025	COG0625	glutathione transferase activity
HF685_RS07035	COG0424	maF-like protein
HF685_RS07040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HF685_RS07085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF685_RS07085	COG1372	Participates in initiation and elongation during chromosome replication
HF685_RS07090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF685_RS07090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HF685_RS07100	COG4667	esterase of the alpha-beta hydrolase superfamily
HF685_RS07105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HF685_RS07105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HF685_RS07140	COG5265	(ABC) transporter
HF685_RS07145	COG0514	ATP-dependent DNA helicase (RecQ)
HF685_RS07175	COG0004	ammonium transporteR
HF685_RS07180	COG0347	Belongs to the P(II) protein family
HF685_RS07185	COG1752	Esterase of the alpha-beta hydrolase superfamily
HF685_RS07210	COG0312	modulator of DNA gyrase
HF685_RS07245	COG1131	(ABC) transporter
HF685_RS07260	COG2366	antibiotic biosynthetic process
HF685_RS07265	COG0542	response to heat
HF685_RS07285	COG4206	TonB-dependent receptor
HF685_RS07295	COG1388	LysM domain
HF685_RS07295	COG4942	peptidase
HF685_RS07305	COG1570	exodeoxyribonuclease VII activity
HF685_RS07310	COG0151	Belongs to the GarS family
HF685_RS07315	COG2130	NADP-dependent
HF685_RS07345	COG2304	oxidoreductase activity
HF685_RS07365	COG2885	chlorophyll binding
HF685_RS07375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF685_RS07380	COG1674	ftsk spoiiie
HF685_RS07405	COG0629	single-stranded DNA binding
HF685_RS07425	COG1902	pentaerythritol trinitrate reductase activity
HF685_RS07460	COG0037	tRNA processing
HF685_RS07480	COG1758	RNA polymerase activity
HF685_RS07485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF685_RS07505	COG0640	Transcriptional regulator
HF685_RS07515	COG1410	methionine synthase
HF685_RS07515	COG0646	methionine synthase
HF685_RS07520	COG1410	methionine synthase
HF685_RS07520	COG0646	methionine synthase
HF685_RS07560	COG0556	nucleotide-excision repair
HF685_RS07585	COG1473	amidohydrolase
HF685_RS07595	COG0824	Thioesterase
HF685_RS07615	COG0823	Involved in the tonB-independent uptake of proteins
HF685_RS07620	COG2885	chlorophyll binding
HF685_RS07630	COG0612	Peptidase, M16
HF685_RS07635	COG0275	rRNA processing
HF685_RS07650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF685_RS07655	COG0583	DNA-binding transcription factor activity
HF685_RS07660	COG0297	glycogen (starch) synthase activity
HF685_RS07685	COG2239	Acts as a magnesium transporter
HF685_RS07755	COG0789	Transcriptional regulator
HF685_RS07780	COG1960	acyl-CoA dehydrogenase activity
HF685_RS07785	COG1960	acyl-CoA dehydrogenase activity
HF685_RS07795	COG2211	Major facilitator Superfamily
HF685_RS07800	COG1960	acyl-CoA dehydrogenase activity
HF685_RS07805	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HF685_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS07835	COG1505	serine-type exopeptidase activity
HF685_RS07840	COG0203	ribosomal protein L17
HF685_RS07845	COG0202	RNA polymerase activity
HF685_RS07850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HF685_RS07855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF685_RS07870	COG0189	ligase activity
HF685_RS07875	COG0189	ligase activity
HF685_RS07875	COG4067	protein conserved in archaea
HF685_RS07890	COG0563	adenylate kinase activity
HF685_RS07895	COG0201	protein transport
HF685_RS07900	COG0200	Binds to the 23S rRNA
HF685_RS07905	COG1841	ribosomal large subunit assembly
HF685_RS07910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HF685_RS07915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HF685_RS07920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HF685_RS07925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HF685_RS07930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HF685_RS07935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HF685_RS07940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HF685_RS07945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HF685_RS07950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HF685_RS07955	COG0255	Belongs to the universal ribosomal protein uL29 family
HF685_RS07960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HF685_RS07965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HF685_RS07970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HF685_RS07975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HF685_RS07980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF685_RS07985	COG0089	rRNA binding
HF685_RS07990	COG0088	Forms part of the polypeptide exit tunnel
HF685_RS07995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HF685_RS08000	COG0051	transcription antitermination factor activity, RNA binding
HF685_RS08005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF685_RS08010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HF685_RS08015	COG0049	tRNA binding
HF685_RS08020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HF685_RS08050	COG1755	Isoprenylcysteine carboxyl methyltransferase
HF685_RS08055	COG3424	synthase
HF685_RS08080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HF685_RS08125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HF685_RS08135	COG0746	molybdenum cofactor guanylyltransferase activity
HF685_RS08145	COG1473	amidohydrolase
HF685_RS08150	COG1960	acyl-CoA dehydrogenase activity
HF685_RS08160	COG1228	amidohydrolase
HF685_RS08180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HF685_RS08200	COG1024	Enoyl-CoA hydratase
HF685_RS08225	COG0730	response to heat
HF685_RS08255	COG2814	Major facilitator Superfamily
HF685_RS08265	COG1024	Enoyl-CoA hydratase
HF685_RS08315	COG0436	Aminotransferase
HF685_RS08345	COG0243	molybdopterin cofactor binding
HF685_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS08375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF685_RS08380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HF685_RS08385	COG0702	epimerase
HF685_RS08415	COG1024	Enoyl-CoA hydratase
HF685_RS08470	COG0708	Exodeoxyribonuclease III
HF685_RS08475	COG0316	Belongs to the HesB IscA family
HF685_RS08480	COG0739	heme binding
HF685_RS08485	COG2833	Protein of unknown function (DUF455)
HF685_RS08490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF685_RS08495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HF685_RS08505	COG0343	queuine tRNA-ribosyltransferase activity
HF685_RS08520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HF685_RS08530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HF685_RS08540	COG1722	exodeoxyribonuclease VII activity
HF685_RS08560	COG4221	oxidoreductase activity
HF685_RS08565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HF685_RS08585	COG2311	Membrane
HF685_RS08605	COG1160	GTP binding
HF685_RS08620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HF685_RS08630	COG0584	glycerophosphoryl diester phosphodiesterase
HF685_RS08640	COG1988	membrane-bound metal-dependent
HF685_RS08645	COG1393	Belongs to the ArsC family
HF685_RS08680	COG0519	Catalyzes the synthesis of GMP from XMP
HF685_RS08680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HF685_RS08695	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HF685_RS08700	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS08725	COG2308	Evidence 4 Homologs of previously reported genes of
HF685_RS08770	COG0519	Catalyzes the synthesis of GMP from XMP
HF685_RS08780	COG2133	pyrroloquinoline quinone binding
HF685_RS08810	COG0617	tRNA 3'-terminal CCA addition
HF685_RS08820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HF685_RS08850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HF685_RS08865	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HF685_RS08870	COG0047	phosphoribosylformylglycinamidine synthase activity
HF685_RS08910	COG4695	Portal protein
HF685_RS08935	COG1115	amino acid carrier protein
HF685_RS08940	COG1238	metal cluster binding
HF685_RS08950	COG4771	TonB-dependent receptor
HF685_RS08965	COG2814	Major facilitator Superfamily
HF685_RS09035	COG0513	Belongs to the DEAD box helicase family
HF685_RS09080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HF685_RS09085	COG0416	fatty acid biosynthetic process
HF685_RS09090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HF685_RS09110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF685_RS09135	COG0438	transferase activity, transferring glycosyl groups
HF685_RS09150	COG4948	Mandelate Racemase Muconate Lactonizing
HF685_RS09165	COG0183	Belongs to the thiolase family
HF685_RS09170	COG0668	transmembrane transport
HF685_RS09175	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HF685_RS09190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HF685_RS09190	COG1648	precorrin-2 dehydrogenase activity
HF685_RS09195	COG0019	diaminopimelate decarboxylase activity
HF685_RS09205	COG0165	Argininosuccinate lyase
HF685_RS09210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HF685_RS09220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF685_RS09235	COG0268	Binds directly to 16S ribosomal RNA
HF685_RS09240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HF685_RS09245	COG2226	methyltransferase
HF685_RS09270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HF685_RS09275	COG0756	dUTP diphosphatase activity
HF685_RS09300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HF685_RS09305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HF685_RS09325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HF685_RS09350	COG0438	transferase activity, transferring glycosyl groups
HF685_RS09395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HF685_RS09410	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HF685_RS09420	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HF685_RS09425	COG1595	DNA-templated transcription, initiation
HF685_RS09455	COG0154	amidase activity
HF685_RS09475	COG2186	Transcriptional regulator
HF685_RS09485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF685_RS09495	COG2030	dehydratase
HF685_RS09520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF685_RS09535	COG2814	Major facilitator Superfamily
HF685_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS09550	COG2271	Major facilitator Superfamily
HF685_RS09560	COG1960	acyl-CoA dehydrogenase activity
HF685_RS09580	COG0714	Associated with various cellular activities
HF685_RS09625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF685_RS09635	COG4555	ABC transporter
HF685_RS09645	COG1053	succinate dehydrogenase
HF685_RS09690	COG2902	Dehydrogenase
HF685_RS09695	COG2733	membrane
HF685_RS09705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF685_RS09725	COG0482	sulfurtransferase activity
HF685_RS09745	COG0259	pyridoxamine-phosphate oxidase activity
HF685_RS09755	COG0484	heat shock protein binding
HF685_RS09760	COG1295	ribonuclease BN
HF685_RS09765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HF685_RS09775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HF685_RS09780	COG3273	potassium ion transport
HF685_RS09780	COG0471	metal ion transport
HF685_RS09785	COG1301	dicarboxylic acid transport
HF685_RS09795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HF685_RS09800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HF685_RS09805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HF685_RS09835	COG3474	cytochrome
HF685_RS09840	COG0077	Prephenate dehydratase
HF685_RS09840	COG1605	Chorismate mutase
HF685_RS09860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF685_RS09860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF685_RS09865	COG3706	GGDEF domain
HF685_RS09870	COG0583	DNA-binding transcription factor activity
HF685_RS09890	COG2855	membrane
HF685_RS09900	COG2814	Major facilitator Superfamily
HF685_RS09905	COG2130	NADP-dependent
HF685_RS09910	COG1760	l-serine dehydratase
HF685_RS09920	COG0459	protein refolding
HF685_RS09925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HF685_RS09935	COG3220	belongs to the UPF0276 family
HF685_RS09950	COG1595	DNA-templated transcription, initiation
HF685_RS09960	COG0616	signal peptide processing
HF685_RS09985	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF685_RS09995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HF685_RS10005	COG0039	L-malate dehydrogenase activity
HF685_RS10020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF685_RS10025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HF685_RS10070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HF685_RS10075	COG1612	heme a metabolic process
HF685_RS10090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HF685_RS10100	COG2171	N-acyltransferase activity
HF685_RS10105	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HF685_RS10110	COG2957	Belongs to the agmatine deiminase family
HF685_RS10115	COG2255	four-way junction helicase activity
HF685_RS10130	COG0632	four-way junction helicase activity
HF685_RS10135	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HF685_RS10140	COG0217	transcriptional regulatory protein
HF685_RS10150	COG0393	Putative heavy-metal-binding
HF685_RS10160	COG3750	Belongs to the UPF0335 family
HF685_RS10180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HF685_RS10195	COG2866	Carboxypeptidase
HF685_RS10235	COG0686	Belongs to the AlaDH PNT family
HF685_RS10250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HF685_RS10255	COG1137	ATPase activity
HF685_RS10280	COG1278	Cold shock
HF685_RS10290	COG2119	membrane
HF685_RS10300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HF685_RS10340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HF685_RS10345	COG1192	Involved in chromosome partitioning
HF685_RS10365	COG5507	3-demethylubiquinone-9 3-methyltransferase
HF685_RS10380	COG1733	regulation of RNA biosynthetic process
HF685_RS10390	COG0628	permease
HF685_RS10440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HF685_RS10460	COG0495	leucyl-tRNA aminoacylation
HF685_RS10480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HF685_RS10495	COG2983	Belongs to the UPF0260 family
HF685_RS10500	COG1999	signal sequence binding
HF685_RS10530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HF685_RS10535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HF685_RS10540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HF685_RS10545	COG0237	dephospho-CoA kinase activity
HF685_RS10550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HF685_RS10555	COG0424	maF-like protein
HF685_RS10560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HF685_RS10565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HF685_RS10575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HF685_RS10580	COG0861	Integral membrane protein TerC family
HF685_RS10605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HF685_RS10610	COG0445	tRNA wobble uridine modification
HF685_RS10615	COG0357	Ribosomal RNA small subunit methyltransferase G
HF685_RS10665	COG2070	2-Nitropropane dioxygenase
HF685_RS10670	COG4770	biotin carboxylase activity
HF685_RS10675	COG1024	Enoyl-CoA hydratase
HF685_RS10680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF685_RS10685	COG1024	Enoyl-CoA hydratase
HF685_RS10685	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF685_RS10690	COG0183	Belongs to the thiolase family
HF685_RS10695	COG1960	acyl-CoA dehydrogenase activity
HF685_RS10700	COG0431	NADPH-dependent FMN reductase
HF685_RS10725	COG1596	polysaccharide export
HF685_RS10735	COG0489	protein tyrosine kinase activity
HF685_RS10790	COG2884	Cell division ATP-binding protein ftsE
HF685_RS10810	COG0287	Prephenate dehydrogenase
HF685_RS10815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HF685_RS10825	COG2813	Specifically methylates the guanine in position
HF685_RS10825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HF685_RS10830	COG2161	toxin-antitoxin pair type II binding
HF685_RS10835	COG4115	mRNA cleavage
HF685_RS10855	COG0072	phenylalanine-tRNA ligase activity
HF685_RS10860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HF685_RS10865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HF685_RS10870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HF685_RS10890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HF685_RS10925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF685_RS10925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF685_RS11035	COG2755	lipolytic protein G-D-S-L family
HF685_RS11035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HF685_RS11065	COG1086	Polysaccharide biosynthesis protein
HF685_RS11075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HF685_RS11120	COG0489	protein tyrosine kinase activity
HF685_RS11150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HF685_RS11165	COG1595	DNA-templated transcription, initiation
HF685_RS11190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF685_RS11200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF685_RS11225	COG0719	Fe-S assembly protein
HF685_RS11235	COG0396	ATPase activity
HF685_RS11245	COG0719	Fe-S assembly protein
HF685_RS11255	COG2151	metal-sulfur cluster biosynthetic enzyme
HF685_RS11260	COG0316	Belongs to the HesB IscA family
HF685_RS11280	COG2086	electron transfer activity
HF685_RS11290	COG0045	succinate-CoA ligase (ADP-forming) activity
HF685_RS11305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HF685_RS11315	COG0124	histidyl-tRNA synthetase
HF685_RS11320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HF685_RS11325	COG2890	protein-(glutamine-N5) methyltransferase activity
HF685_RS11340	COG0418	dihydroorotase activity
HF685_RS11345	COG2962	Rard protein
HF685_RS11390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HF685_RS11395	COG0235	Class ii aldolase
HF685_RS11400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HF685_RS11435	COG0180	Tryptophanyl-tRNA synthetase
HF685_RS11440	COG0728	peptidoglycan biosynthetic process
HF685_RS11445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HF685_RS11450	COG4395	Tim44
HF685_RS11465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF685_RS11475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HF685_RS11480	COG0706	membrane insertase activity
HF685_RS11485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HF685_RS11495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HF685_RS11525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HF685_RS11530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HF685_RS11535	COG0799	negative regulation of ribosome biogenesis
HF685_RS11540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HF685_RS11550	COG0793	Belongs to the peptidase S41A family
HF685_RS11560	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HF685_RS11585	COG2070	2-Nitropropane dioxygenase
HF685_RS11590	COG0527	aspartate kinase activity
HF685_RS11595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF685_RS11645	COG1968	undecaprenyl-diphosphatase activity
HF685_RS11660	COG3311	Transcriptional regulator
HF685_RS11745	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HF685_RS11755	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HF685_RS11765	COG0582	viral genome integration into host DNA
HF685_RS11770	COG0582	viral genome integration into host DNA
HF685_RS11820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF685_RS11855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HF685_RS11860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF685_RS11870	COG1335	isochorismatase
HF685_RS11875	COG4974	Belongs to the 'phage' integrase family
HF685_RS11880	COG0629	single-stranded DNA binding
HF685_RS11995	COG0625	glutathione transferase activity
HF685_RS12010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HF685_RS12045	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF685_RS12045	COG1024	Enoyl-CoA hydratase
HF685_RS12065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HF685_RS12070	COG2986	histidine ammonia-lyase
HF685_RS12075	COG1228	amidohydrolase
HF685_RS12080	COG0010	Belongs to the arginase family
HF685_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS12100	COG1960	acyl-CoA dehydrogenase activity
HF685_RS12105	COG1960	acyl-CoA dehydrogenase activity
HF685_RS12110	COG1024	Enoyl-CoA hydratase
HF685_RS12130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HF685_RS12140	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS12155	COG1960	acyl-CoA dehydrogenase activity
HF685_RS12160	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HF685_RS12165	COG1024	Enoyl-CoA hydratase
HF685_RS12205	COG0183	Belongs to the thiolase family
HF685_RS12215	COG1024	Enoyl-CoA hydratase
HF685_RS12245	COG1522	sequence-specific DNA binding
HF685_RS12270	COG2271	Major facilitator Superfamily
HF685_RS12305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HF685_RS12320	COG2267	carboxylic ester hydrolase activity
HF685_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS12370	COG0501	Belongs to the peptidase M48B family
HF685_RS12380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HF685_RS12390	COG0138	bifunctional purine biosynthesis protein purh
HF685_RS12405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HF685_RS12415	COG0196	riboflavin kinase activity
HF685_RS12430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HF685_RS12435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HF685_RS12445	COG0588	phosphoglycerate mutase activity
HF685_RS12460	COG4771	TonB-dependent receptor
HF685_RS12465	COG1454	alcohol dehydrogenase
HF685_RS12505	COG0174	glutamine synthetase
HF685_RS12520	COG0024	Methionine aminopeptidase
HF685_RS12530	COG1546	Belongs to the CinA family
HF685_RS12530	COG1058	Belongs to the CinA family
HF685_RS12560	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HF685_RS12575	COG0588	phosphoglycerate mutase activity
HF685_RS12590	COG0776	regulation of translation
HF685_RS12630	COG1174	glycine betaine transport
HF685_RS12635	COG1125	glycine betaine transport
HF685_RS12635	COG0517	IMP dehydrogenase activity
HF685_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS12645	COG2154	pterin-4-alpha-carbinolamine dehydratase
HF685_RS12650	COG4133	protoheme IX ABC transporter activity
HF685_RS12690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HF685_RS12700	COG0439	Biotin carboxylase
HF685_RS12705	COG0511	ligase activity, forming carbon-carbon bonds
HF685_RS12710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HF685_RS12715	COG2022	thiamine diphosphate biosynthetic process
HF685_RS12730	COG3275	phosphorelay sensor kinase activity
HF685_RS12770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HF685_RS12775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HF685_RS12780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HF685_RS12795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HF685_RS12800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HF685_RS12815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HF685_RS12825	COG0113	porphobilinogen synthase activity
HF685_RS12835	COG0739	heme binding
HF685_RS12850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HF685_RS12855	COG1329	Transcriptional regulator
HF685_RS12865	COG2226	methyltransferase
HF685_RS12895	COG1960	acyl-CoA dehydrogenase activity
HF685_RS12900	COG0009	L-threonylcarbamoyladenylate synthase
HF685_RS12915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF685_RS12920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HF685_RS12940	COG1280	lysine exporter protein (LysE YggA)
HF685_RS12945	COG0583	DNA-binding transcription factor activity
HF685_RS12950	COG1741	Belongs to the pirin family
HF685_RS12955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HF685_RS12960	COG0753	catalase activity
HF685_RS12970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HF685_RS12980	COG0085	RNA polymerase activity
HF685_RS12990	COG3655	Transcriptional regulator
HF685_RS13000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HF685_RS13020	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HF685_RS13040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HF685_RS13055	COG0222	ribosome binding
HF685_RS13060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HF685_RS13080	COG0081	regulation of translation
HF685_RS13085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HF685_RS13130	COG2832	Protein of unknown function (DUF454)
HF685_RS13135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HF685_RS13145	COG0583	DNA-binding transcription factor activity
HF685_RS13150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HF685_RS13175	COG2137	regulation of response to DNA damage stimulus
HF685_RS13180	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS13185	COG5001	Diguanylate cyclase
HF685_RS13190	COG1192	Involved in chromosome partitioning
HF685_RS13195	COG1393	Belongs to the ArsC family
HF685_RS13200	COG4774	siderophore transport
HF685_RS13210	COG0235	Class ii aldolase
HF685_RS13215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HF685_RS13250	COG3275	phosphorelay sensor kinase activity
HF685_RS13255	COG3279	Response regulator of the LytR AlgR family
HF685_RS13260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HF685_RS13320	COG0398	Pfam SNARE associated Golgi protein
HF685_RS13325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF685_RS13335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HF685_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS13345	COG4206	TonB-dependent receptor
HF685_RS13360	COG2130	NADP-dependent
HF685_RS13370	COG0183	Belongs to the thiolase family
HF685_RS13390	COG1960	acyl-CoA dehydrogenase activity
HF685_RS13395	COG1960	acyl-CoA dehydrogenase activity
HF685_RS13400	COG2130	NADP-dependent
HF685_RS13415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HF685_RS13420	COG0022	dehydrogenase e1 component
HF685_RS13465	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS13480	COG0729	surface antigen
HF685_RS13495	COG1959	2 iron, 2 sulfur cluster binding
HF685_RS13495	COG1295	ribonuclease BN
HF685_RS13510	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HF685_RS13510	COG3264	Mechanosensitive ion channel
HF685_RS13520	COG4221	oxidoreductase activity
HF685_RS13540	COG4771	TonB-dependent receptor
HF685_RS13550	COG2186	Transcriptional regulator
HF685_RS13570	COG2271	Major facilitator Superfamily
HF685_RS13580	COG0800	Aldolase
HF685_RS13595	COG1312	Catalyzes the dehydration of D-mannonate
HF685_RS13665	COG1607	acyl-coa hydrolase
HF685_RS13675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HF685_RS13675	COG3620	sequence-specific DNA binding
HF685_RS13675	COG0617	tRNA 3'-terminal CCA addition
HF685_RS13725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HF685_RS13735	COG0123	including yeast histone deacetylase and acetoin utilization protein
HF685_RS13760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HF685_RS13765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HF685_RS13775	COG0531	amino acid
HF685_RS13785	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HF685_RS13815	COG0673	inositol 2-dehydrogenase activity
HF685_RS13820	COG0656	L-ascorbic acid biosynthetic process
HF685_RS13830	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF685_RS13840	COG1404	Belongs to the peptidase S8 family
HF685_RS13855	COG2197	response regulator
HF685_RS13865	COG4152	abc transporter atp-binding protein
HF685_RS13870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HF685_RS13890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HF685_RS13900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HF685_RS13910	COG0181	hydroxymethylbilane synthase activity
HF685_RS13935	COG0006	proline dipeptidase activity
HF685_RS13940	COG0824	Thioesterase
HF685_RS13955	COG0427	acetyl-CoA hydrolase
HF685_RS13965	COG1137	ATPase activity
HF685_RS14000	COG1024	Enoyl-CoA hydratase
HF685_RS14000	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF685_RS14005	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS14010	COG1946	Acyl-CoA thioesterase
HF685_RS14015	COG0183	Belongs to the thiolase family
HF685_RS14030	COG2003	Belongs to the UPF0758 family
HF685_RS14060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HF685_RS14085	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS14140	COG2311	Membrane
HF685_RS14160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF685_RS14180	COG0668	transmembrane transport
HF685_RS14200	COG0784	Response regulator, receiver
HF685_RS14220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF685_RS14240	COG1573	uracil-dna glycosylase
HF685_RS14250	COG0477	Major facilitator Superfamily
HF685_RS14255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HF685_RS14260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF685_RS14265	COG1845	cytochrome c oxidase, subunit III
HF685_RS14270	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HF685_RS14285	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HF685_RS14305	COG4974	Belongs to the 'phage' integrase family
HF685_RS14310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF685_RS14330	COG2181	nitrate reductase activity
HF685_RS14335	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HF685_RS14340	COG1140	nitrate reductase beta subunit
HF685_RS14345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HF685_RS14350	COG2223	nitrite transmembrane transporter activity
HF685_RS14365	COG0629	single-stranded DNA binding
HF685_RS14425	COG0629	single-stranded DNA binding
HF685_RS14430	COG0582	viral genome integration into host DNA
HF685_RS14440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HF685_RS14460	COG1494	fructose-1,6-bisphosphatase
HF685_RS14500	COG1132	(ABC) transporter
HF685_RS14525	COG1846	Transcriptional regulator
HF685_RS14530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HF685_RS14540	COG0745	RESPONSE REGULATOR receiver
HF685_RS14550	COG2205	protein histidine kinase activity
HF685_RS14565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HF685_RS14585	COG2972	Histidine kinase
HF685_RS14590	COG3279	Response regulator of the LytR AlgR family
HF685_RS14595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HF685_RS14620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HF685_RS14625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HF685_RS14640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF685_RS14655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF685_RS14660	COG3300	MHYT domain
HF685_RS14660	COG5001	Diguanylate cyclase
HF685_RS14665	COG2072	flavoprotein involved in K transport
HF685_RS14670	COG2072	flavoprotein involved in K transport
HF685_RS14675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF685_RS14680	COG0791	NLP P60 protein
HF685_RS14695	COG0736	holo-[acyl-carrier-protein] synthase activity
HF685_RS14700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HF685_RS14705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HF685_RS14710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HF685_RS14715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF685_RS14720	COG0109	protoheme IX farnesyltransferase activity
HF685_RS14730	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HF685_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS14775	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HF685_RS14780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HF685_RS14795	COG0028	Belongs to the TPP enzyme family
HF685_RS14830	COG1459	type II secretion system
HF685_RS14905	COG2815	serine threonine protein kinase
HF685_RS14905	COG0515	serine threonine protein kinase
HF685_RS14915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HF685_RS14950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HF685_RS14955	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HF685_RS14960	COG5342	invasion associated locus B
HF685_RS14965	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF685_RS14970	COG0596	Alpha beta hydrolase
HF685_RS14980	COG0789	Transcriptional regulator
HF685_RS14990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HF685_RS14995	COG4172	Belongs to the ABC transporter superfamily
HF685_RS15010	COG0668	transmembrane transport
HF685_RS15015	COG0626	cystathionine gamma-synthase activity
HF685_RS15020	COG2897	thiosulfate sulfurtransferase activity
HF685_RS15025	COG3046	protein related to deoxyribodipyrimidine photolyase
HF685_RS15040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HF685_RS15060	COG0433	COG0433 Predicted ATPase
HF685_RS15080	COG0489	protein tyrosine kinase activity
HF685_RS15085	COG1832	CoA-binding protein
HF685_RS15095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HF685_RS15110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HF685_RS15125	COG0546	phosphoglycolate phosphatase activity
HF685_RS15145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HF685_RS15160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF685_RS15180	COG0339	signal peptide processing
HF685_RS15185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF685_RS15200	COG1309	transcriptional regulator
HF685_RS15210	COG1902	pentaerythritol trinitrate reductase activity
HF685_RS15210	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF685_RS15230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HF685_RS15235	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS15240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HF685_RS15260	COG0280	phosphate acetyltransferase
HF685_RS15260	COG0281	malic enzyme
HF685_RS15265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HF685_RS15270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HF685_RS15280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HF685_RS15290	COG2095	MarC family integral membrane protein
HF685_RS15295	COG2835	tetraacyldisaccharide 4'-kinase activity
HF685_RS15340	COG0745	RESPONSE REGULATOR receiver
HF685_RS15355	COG2226	methyltransferase
HF685_RS15360	COG0640	Transcriptional regulator
HF685_RS15365	COG0450	alkyl hydroperoxide reductase
HF685_RS15380	COG2391	methyltransferase activity
HF685_RS15390	COG0837	glucose binding
HF685_RS15410	COG2032	superoxide dismutase activity
HF685_RS15415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HF685_RS15420	COG0670	Belongs to the BI1 family
HF685_RS15445	COG0604	alcohol dehydrogenase
HF685_RS15445	COG1028	Short-chain dehydrogenase reductase Sdr
HF685_RS15445	COG3321	synthase
HF685_RS15465	COG0318	PFAM AMP-dependent synthetase and ligase
HF685_RS15525	COG2010	Cytochrome c
HF685_RS15565	COG4566	intracellular signal transduction
HF685_RS15570	COG4191	Histidine kinase
HF685_RS15595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HF685_RS15640	COG1862	Preprotein translocase
HF685_RS15645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF685_RS15650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF685_RS15660	COG0438	transferase activity, transferring glycosyl groups
HF685_RS15685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HF685_RS15705	COG2205	protein histidine kinase activity
HF685_RS15710	COG0493	'glutamate synthase
HF685_RS15720	COG0142	geranyltranstransferase activity
HF685_RS15740	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HF685_RS15745	COG1704	LemA family
HF685_RS15750	COG1970	mechanosensitive ion channel activity
HF685_RS15775	COG3724	N-succinylarginine dihydrolase activity
HF685_RS15785	COG1473	amidohydrolase
HF685_RS15790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HF685_RS15795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HF685_RS15800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HF685_RS15810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HF685_RS15815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF685_RS15830	COG0105	UTP biosynthetic process
HF685_RS15850	COG1595	DNA-templated transcription, initiation
HF685_RS15865	COG4566	intracellular signal transduction
HF685_RS15870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HF685_RS15875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HF685_RS15890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HF685_RS15895	COG0248	Ppx GppA phosphatase
HF685_RS15900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HF685_RS15915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HF685_RS15920	COG0596	Alpha beta hydrolase
HF685_RS15940	COG0741	lytic transglycosylase activity
HF685_RS15945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF685_RS15950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HF685_RS15965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HF685_RS15975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HF685_RS15990	COG0538	isocitrate dehydrogenase activity
HF685_RS16005	COG0052	Belongs to the universal ribosomal protein uS2 family
HF685_RS16010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome