locus-tag	class	description
SmB9_RS00005	COG2003	Belongs to the UPF0758 family
SmB9_RS00075	COG1959	2 iron, 2 sulfur cluster binding
SmB9_RS00130	COG1309	transcriptional regulator
SmB9_RS00180	COG0596	Alpha beta hydrolase
SmB9_RS00185	COG0028	Belongs to the TPP enzyme family
SmB9_RS00200	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS00230	COG0596	Alpha beta hydrolase
SmB9_RS00280	COG1506	peptidase
SmB9_RS00280	COG0823	Involved in the tonB-independent uptake of proteins
SmB9_RS00335	COG3104	oligopeptide transport
SmB9_RS00355	COG0733	neurotransmitter:sodium symporter activity
SmB9_RS00360	COG1448	Aminotransferase
SmB9_RS00370	COG2936	dipeptidyl-peptidase activity
SmB9_RS00375	COG2814	Major facilitator Superfamily
SmB9_RS00385	COG0277	FAD linked oxidase domain protein
SmB9_RS00390	COG2211	Major facilitator Superfamily
SmB9_RS00395	COG0534	Mate efflux family protein
SmB9_RS00400	COG1802	Transcriptional regulator
SmB9_RS00405	COG4771	TonB-dependent receptor
SmB9_RS00410	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS00415	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SmB9_RS00435	COG4948	Mandelate Racemase Muconate Lactonizing
SmB9_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS00450	COG2843	Capsule synthesis protein
SmB9_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS00495	COG1053	succinate dehydrogenase
SmB9_RS00525	COG1309	transcriptional regulator
SmB9_RS00530	COG4771	TonB-dependent receptor
SmB9_RS00535	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS00540	COG2814	Major facilitator Superfamily
SmB9_RS00560	COG3104	oligopeptide transport
SmB9_RS00575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS00585	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS00595	COG1024	Enoyl-CoA hydratase
SmB9_RS00600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SmB9_RS00605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SmB9_RS00625	COG1024	Enoyl-CoA hydratase
SmB9_RS00655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS00665	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS00675	COG4771	TonB-dependent receptor
SmB9_RS00715	COG1968	undecaprenyl-diphosphatase activity
SmB9_RS00745	COG2902	Dehydrogenase
SmB9_RS00765	COG0582	viral genome integration into host DNA
SmB9_RS00780	COG4957	zinc ion binding
SmB9_RS00805	COG0657	acetylesterase activity
SmB9_RS00825	COG0183	Belongs to the thiolase family
SmB9_RS00835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS00840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SmB9_RS00845	COG4771	TonB-dependent receptor
SmB9_RS00855	COG0154	amidase activity
SmB9_RS00865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SmB9_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS00935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SmB9_RS00940	COG0022	dehydrogenase e1 component
SmB9_RS00950	COG0095	Lipoate-protein ligase
SmB9_RS00955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS00965	COG4771	TonB-dependent receptor
SmB9_RS00975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS00995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS01005	COG1522	sequence-specific DNA binding
SmB9_RS01030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SmB9_RS01040	COG1271	oxidase subunit
SmB9_RS01045	COG1294	oxidase, subunit
SmB9_RS01060	COG0583	DNA-binding transcription factor activity
SmB9_RS01090	COG4771	TonB-dependent receptor
SmB9_RS01095	COG3474	cytochrome
SmB9_RS01135	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SmB9_RS01140	COG1418	mRNA catabolic process
SmB9_RS01145	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SmB9_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS01170	COG1522	sequence-specific DNA binding
SmB9_RS01210	COG3088	subunit of a heme lyase
SmB9_RS01215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SmB9_RS01220	COG1138	Cytochrome C-type biogenesis protein
SmB9_RS01230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SmB9_RS01240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SmB9_RS01245	COG0339	signal peptide processing
SmB9_RS01255	COG0513	Belongs to the DEAD box helicase family
SmB9_RS01315	COG0306	phosphate transporter
SmB9_RS01320	COG1392	Phosphate transport regulator
SmB9_RS01325	COG0640	Transcriptional regulator
SmB9_RS01340	COG0625	glutathione transferase activity
SmB9_RS01355	COG3038	cytochrome b561
SmB9_RS01360	COG1238	metal cluster binding
SmB9_RS01370	COG3422	double-strand break repair
SmB9_RS01375	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SmB9_RS01395	COG0823	Involved in the tonB-independent uptake of proteins
SmB9_RS01395	COG1506	peptidase
SmB9_RS01395	COG4946	Tricorn protease homolog
SmB9_RS01415	COG1278	Cold shock
SmB9_RS01430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SmB9_RS01440	COG0626	cystathionine gamma-synthase activity
SmB9_RS01450	COG3920	Histidine kinase
SmB9_RS01455	COG0072	phenylalanine-tRNA ligase activity
SmB9_RS01460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SmB9_RS01465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SmB9_RS01470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SmB9_RS01475	COG1280	lysine exporter protein (LysE YggA)
SmB9_RS01490	COG0483	inositol monophosphate 1-phosphatase activity
SmB9_RS01510	COG0436	Aminotransferase
SmB9_RS01550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SmB9_RS01600	COG3038	cytochrome b561
SmB9_RS01610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SmB9_RS01625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SmB9_RS01630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SmB9_RS01655	COG0360	Binds together with S18 to 16S ribosomal RNA
SmB9_RS01660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SmB9_RS01665	COG0359	binds to the 23S rRNA
SmB9_RS01680	COG3949	Membrane
SmB9_RS01695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SmB9_RS01700	COG4948	Mandelate Racemase Muconate Lactonizing
SmB9_RS01745	COG2010	Cytochrome c
SmB9_RS01780	COG3047	cAMP biosynthetic process
SmB9_RS01785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SmB9_RS01800	COG3383	formate dehydrogenase (NAD+) activity
SmB9_RS01810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SmB9_RS01820	COG1764	response to oxidative stress
SmB9_RS01825	COG1643	Atp-dependent helicase
SmB9_RS01850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SmB9_RS01860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SmB9_RS01865	COG0235	Class ii aldolase
SmB9_RS01875	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS01880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SmB9_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS01935	COG1737	Transcriptional regulator
SmB9_RS01950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SmB9_RS01965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SmB9_RS01970	COG1522	sequence-specific DNA binding
SmB9_RS01985	COG0583	DNA-binding transcription factor activity
SmB9_RS01990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SmB9_RS02000	COG2205	protein histidine kinase activity
SmB9_RS02020	COG1024	Enoyl-CoA hydratase
SmB9_RS02025	COG1024	Enoyl-CoA hydratase
SmB9_RS02030	COG0343	queuine tRNA-ribosyltransferase activity
SmB9_RS02040	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SmB9_RS02050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SmB9_RS02060	COG1722	exodeoxyribonuclease VII activity
SmB9_RS02075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SmB9_RS02080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SmB9_RS02085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SmB9_RS02090	COG0509	glycine decarboxylation via glycine cleavage system
SmB9_RS02095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SmB9_RS02105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SmB9_RS02110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SmB9_RS02115	COG0328	RNA-DNA hybrid ribonuclease activity
SmB9_RS02145	COG4964	Belongs to the GSP D family
SmB9_RS02175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS02180	COG3743	rRNA binding
SmB9_RS02180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SmB9_RS02205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SmB9_RS02205	COG0574	Belongs to the PEP-utilizing enzyme family
SmB9_RS02210	COG0751	glycine-tRNA ligase activity
SmB9_RS02215	COG0752	glycyl-tRNA synthetase alpha subunit
SmB9_RS02240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SmB9_RS02245	COG0193	aminoacyl-tRNA hydrolase activity
SmB9_RS02250	COG0012	GTP binding
SmB9_RS02260	COG2030	dehydratase
SmB9_RS02265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SmB9_RS02270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SmB9_RS02285	COG0723	plastoquinol--plastocyanin reductase activity
SmB9_RS02290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SmB9_RS02295	COG0408	coproporphyrinogen oxidase activity
SmB9_RS02305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SmB9_RS02310	COG0271	Belongs to the BolA IbaG family
SmB9_RS02325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SmB9_RS02335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SmB9_RS02340	COG0047	phosphoribosylformylglycinamidine synthase activity
SmB9_RS02365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SmB9_RS02370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SmB9_RS02395	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SmB9_RS02405	COG0425	Belongs to the sulfur carrier protein TusA family
SmB9_RS02440	COG5001	Diguanylate cyclase
SmB9_RS02440	COG3300	MHYT domain
SmB9_RS02475	COG0308	aminopeptidase N
SmB9_RS02490	COG2814	Major facilitator Superfamily
SmB9_RS02505	COG1473	amidohydrolase
SmB9_RS02515	COG0625	glutathione transferase activity
SmB9_RS02520	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS02530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SmB9_RS02540	COG0438	transferase activity, transferring glycosyl groups
SmB9_RS02555	COG4221	oxidoreductase activity
SmB9_RS02555	COG3321	synthase
SmB9_RS02555	COG0604	alcohol dehydrogenase
SmB9_RS02555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SmB9_RS02570	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS02585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SmB9_RS02595	COG1505	serine-type exopeptidase activity
SmB9_RS02615	COG2032	superoxide dismutase activity
SmB9_RS02665	COG0670	Belongs to the BI1 family
SmB9_RS02675	COG4181	ATPase activity
SmB9_RS02685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SmB9_RS02690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SmB9_RS02705	COG0596	Alpha beta hydrolase
SmB9_RS02710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SmB9_RS02715	COG0321	lipoyl(octanoyl) transferase activity
SmB9_RS02740	COG2885	chlorophyll binding
SmB9_RS02740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SmB9_RS02840	COG4695	Portal protein
SmB9_RS02885	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS02900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SmB9_RS02905	COG0312	modulator of DNA gyrase
SmB9_RS02910	COG1832	CoA-binding protein
SmB9_RS02915	COG0489	protein tyrosine kinase activity
SmB9_RS02920	COG0330	HflC and HflK could
SmB9_RS02940	COG0433	COG0433 Predicted ATPase
SmB9_RS02950	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SmB9_RS02955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SmB9_RS02960	COG0196	riboflavin kinase activity
SmB9_RS02975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SmB9_RS02980	COG1215	transferase activity, transferring glycosyl groups
SmB9_RS03005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SmB9_RS03005	COG2169	Transcriptional regulator
SmB9_RS03010	COG0730	response to heat
SmB9_RS03030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SmB9_RS03040	COG0316	Belongs to the HesB IscA family
SmB9_RS03045	COG2151	metal-sulfur cluster biosynthetic enzyme
SmB9_RS03055	COG0719	Fe-S assembly protein
SmB9_RS03060	COG0396	ATPase activity
SmB9_RS03065	COG0719	Fe-S assembly protein
SmB9_RS03080	COG0167	dihydroorotate dehydrogenase activity
SmB9_RS03090	COG1022	Amp-dependent synthetase and ligase
SmB9_RS03095	COG0697	spore germination
SmB9_RS03110	COG4152	abc transporter atp-binding protein
SmB9_RS03115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SmB9_RS03125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SmB9_RS03130	COG0531	amino acid
SmB9_RS03140	COG0140	phosphoribosyl-ATP diphosphatase activity
SmB9_RS03145	COG0107	imidazoleglycerol-phosphate synthase activity
SmB9_RS03150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SmB9_RS03155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SmB9_RS03160	COG0131	Imidazoleglycerol-phosphate dehydratase
SmB9_RS03170	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SmB9_RS03175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SmB9_RS03200	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SmB9_RS03210	COG0180	Tryptophanyl-tRNA synthetase
SmB9_RS03230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SmB9_RS03235	COG0778	Nitroreductase
SmB9_RS03240	COG1214	PFAM Peptidase M22, glycoprotease
SmB9_RS03260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SmB9_RS03265	COG1702	phosphate starvation-inducible protein PhoH
SmB9_RS03270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SmB9_RS03275	COG4535	Mg2 and Co2 transporter CorC
SmB9_RS03280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SmB9_RS03290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SmB9_RS03310	COG0739	heme binding
SmB9_RS03315	COG2154	pterin-4-alpha-carbinolamine dehydratase
SmB9_RS03325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SmB9_RS03340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SmB9_RS03350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SmB9_RS03375	COG0204	Acyl-transferase
SmB9_RS03375	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS03405	COG0745	RESPONSE REGULATOR receiver
SmB9_RS03410	COG2205	protein histidine kinase activity
SmB9_RS03430	COG1760	l-serine dehydratase
SmB9_RS03445	COG0587	DNA-directed DNA polymerase activity
SmB9_RS03470	COG0640	Transcriptional regulator
SmB9_RS03475	COG2832	Protein of unknown function (DUF454)
SmB9_RS03485	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SmB9_RS03515	COG0582	viral genome integration into host DNA
SmB9_RS03520	COG5489	Protein of unknown function (DUF736)
SmB9_RS03525	COG4957	zinc ion binding
SmB9_RS03535	COG3344	reverse transcriptase
SmB9_RS03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmB9_RS03565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmB9_RS03585	COG0672	)-iron permease
SmB9_RS03710	COG3118	belongs to the thioredoxin family
SmB9_RS03725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SmB9_RS03730	COG1674	ftsk spoiiie
SmB9_RS03735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SmB9_RS03760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SmB9_RS03780	COG0495	leucyl-tRNA aminoacylation
SmB9_RS03810	COG5328	Belongs to the UPF0262 family
SmB9_RS03815	COG0717	Belongs to the dCTP deaminase family
SmB9_RS03820	COG2962	Rard protein
SmB9_RS03825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SmB9_RS03855	COG2983	Belongs to the UPF0260 family
SmB9_RS03860	COG1999	signal sequence binding
SmB9_RS03875	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SmB9_RS03900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SmB9_RS03905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SmB9_RS03920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SmB9_RS03925	COG0424	maF-like protein
SmB9_RS03930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SmB9_RS03935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SmB9_RS03940	COG1981	membrane
SmB9_RS03945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SmB9_RS03950	COG0861	Integral membrane protein TerC family
SmB9_RS03980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SmB9_RS03985	COG0445	tRNA wobble uridine modification
SmB9_RS03990	COG0357	Ribosomal RNA small subunit methyltransferase G
SmB9_RS04005	COG1970	mechanosensitive ion channel activity
SmB9_RS04015	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SmB9_RS04025	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS04045	COG0302	gtp cyclohydrolase
SmB9_RS04060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SmB9_RS04070	COG0477	Major facilitator Superfamily
SmB9_RS04075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SmB9_RS04085	COG1230	cation diffusion facilitator family transporter
SmB9_RS04095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SmB9_RS04100	COG1250	3-hydroxyacyl-CoA dehydrogenase
SmB9_RS04110	COG2086	electron transfer activity
SmB9_RS04145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SmB9_RS04165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SmB9_RS04175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SmB9_RS04180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SmB9_RS04190	COG0456	acetyltransferase
SmB9_RS04195	COG2267	carboxylic ester hydrolase activity
SmB9_RS04200	COG0280	phosphate acetyltransferase
SmB9_RS04200	COG0281	malic enzyme
SmB9_RS04205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SmB9_RS04210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SmB9_RS04230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SmB9_RS04240	COG0596	Alpha beta hydrolase
SmB9_RS04250	COG1136	(ABC) transporter
SmB9_RS04255	COG4591	ABC-type transport system involved in lipoprotein release permease component
SmB9_RS04260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmB9_RS04275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SmB9_RS04285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SmB9_RS04290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SmB9_RS04295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SmB9_RS04315	COG0577	efflux transmembrane transporter activity
SmB9_RS04315	COG1136	(ABC) transporter
SmB9_RS04320	COG0577	efflux transmembrane transporter activity
SmB9_RS04320	COG1136	(ABC) transporter
SmB9_RS04330	COG1959	2 iron, 2 sulfur cluster binding
SmB9_RS04355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SmB9_RS04390	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS04400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SmB9_RS04405	COG2151	metal-sulfur cluster biosynthetic enzyme
SmB9_RS04410	COG3396	Phenylacetate-CoA oxygenase
SmB9_RS04415	COG3460	Phenylacetate-CoA oxygenase
SmB9_RS04420	COG3396	Phenylacetate-CoA oxygenase
SmB9_RS04425	COG0183	Belongs to the thiolase family
SmB9_RS04430	COG2050	protein possibly involved in aromatic compounds catabolism
SmB9_RS04435	COG1024	Enoyl-CoA hydratase
SmB9_RS04440	COG2030	dehydratase
SmB9_RS04440	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS04455	COG4771	TonB-dependent receptor
SmB9_RS04460	COG4771	TonB-dependent receptor
SmB9_RS04480	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SmB9_RS04485	COG0145	ligase activity
SmB9_RS04495	COG4647	ligase activity
SmB9_RS04500	COG0145	ligase activity
SmB9_RS04505	COG1309	transcriptional regulator
SmB9_RS04510	COG2267	carboxylic ester hydrolase activity
SmB9_RS04520	COG0514	ATP-dependent DNA helicase (RecQ)
SmB9_RS04540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SmB9_RS04545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SmB9_RS04555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SmB9_RS04560	COG0424	maF-like protein
SmB9_RS04570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
SmB9_RS04580	COG0582	viral genome integration into host DNA
SmB9_RS04585	COG1396	sequence-specific DNA binding
SmB9_RS04600	COG0251	oxidation-reduction process
SmB9_RS04615	COG0183	Belongs to the thiolase family
SmB9_RS04625	COG3384	dioxygenase
SmB9_RS04635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SmB9_RS04645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SmB9_RS04660	COG0179	Fumarylacetoacetate (FAA) hydrolase
SmB9_RS04665	COG0028	Belongs to the TPP enzyme family
SmB9_RS04670	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS04675	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS04685	COG0183	Belongs to the thiolase family
SmB9_RS04690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SmB9_RS04695	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS04700	COG4771	TonB-dependent receptor
SmB9_RS04715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SmB9_RS04725	COG0308	aminopeptidase N
SmB9_RS04740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SmB9_RS04745	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS04750	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS04855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SmB9_RS04905	COG2079	MmgE PrpD family protein
SmB9_RS04915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SmB9_RS04920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SmB9_RS04955	COG3226	Transcriptional regulator
SmB9_RS04960	COG4773	Receptor
SmB9_RS04965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SmB9_RS04975	COG0833	amino acid
SmB9_RS04990	COG3706	GGDEF domain
SmB9_RS04995	COG0513	Belongs to the DEAD box helicase family
SmB9_RS05010	COG0277	FAD linked oxidase domain protein
SmB9_RS05015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SmB9_RS05025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SmB9_RS05030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SmB9_RS05040	COG1131	(ABC) transporter
SmB9_RS05055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SmB9_RS05055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SmB9_RS05060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SmB9_RS05065	COG5425	PFAM Usg family protein
SmB9_RS05070	COG0443	Heat shock 70 kDa protein
SmB9_RS05080	COG2070	2-Nitropropane dioxygenase
SmB9_RS05095	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS05110	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS05115	COG1024	Enoyl-CoA hydratase
SmB9_RS05120	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS05130	COG1024	Enoyl-CoA hydratase
SmB9_RS05135	COG2124	cytochrome p450
SmB9_RS05140	COG0427	acetyl-CoA hydrolase
SmB9_RS05145	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS05205	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS05220	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS05225	COG1024	Enoyl-CoA hydratase
SmB9_RS05245	COG2205	protein histidine kinase activity
SmB9_RS05250	COG0745	RESPONSE REGULATOR receiver
SmB9_RS05255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmB9_RS05260	COG0577	efflux transmembrane transporter activity
SmB9_RS05260	COG1136	(ABC) transporter
SmB9_RS05310	COG0517	IMP dehydrogenase activity
SmB9_RS05325	COG4974	Belongs to the 'phage' integrase family
SmB9_RS05350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SmB9_RS05405	COG0582	viral genome integration into host DNA
SmB9_RS05415	COG1546	Belongs to the CinA family
SmB9_RS05415	COG1058	Belongs to the CinA family
SmB9_RS05425	COG0024	Methionine aminopeptidase
SmB9_RS05430	COG0454	-acetyltransferase
SmB9_RS05440	COG2003	Belongs to the UPF0758 family
SmB9_RS05445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SmB9_RS05455	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
SmB9_RS05465	COG0588	phosphoglycerate mutase activity
SmB9_RS05470	COG2866	Carboxypeptidase
SmB9_RS05485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SmB9_RS05490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SmB9_RS05500	COG0469	pyruvate kinase activity
SmB9_RS05510	COG3750	Belongs to the UPF0335 family
SmB9_RS05525	COG0393	Putative heavy-metal-binding
SmB9_RS05530	COG0217	transcriptional regulatory protein
SmB9_RS05535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SmB9_RS05540	COG0632	four-way junction helicase activity
SmB9_RS05550	COG2255	four-way junction helicase activity
SmB9_RS05555	COG0824	Thioesterase
SmB9_RS05575	COG0823	Involved in the tonB-independent uptake of proteins
SmB9_RS05580	COG2885	chlorophyll binding
SmB9_RS05590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SmB9_RS05610	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SmB9_RS05615	COG0124	histidyl-tRNA synthetase
SmB9_RS05620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SmB9_RS05625	COG2890	protein-(glutamine-N5) methyltransferase activity
SmB9_RS05635	COG3746	phosphate-selective porin O and P
SmB9_RS05645	COG0517	IMP dehydrogenase activity
SmB9_RS05685	COG1285	pathogenesis
SmB9_RS05695	COG0659	secondary active sulfate transmembrane transporter activity
SmB9_RS05705	COG1024	Enoyl-CoA hydratase
SmB9_RS05710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SmB9_RS05715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SmB9_RS05720	COG0109	protoheme IX farnesyltransferase activity
SmB9_RS05725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SmB9_RS05750	COG2323	membrane
SmB9_RS05770	COG0612	Peptidase, M16
SmB9_RS05775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SmB9_RS05775	COG0116	Belongs to the methyltransferase superfamily
SmB9_RS05780	COG0456	acetyltransferase
SmB9_RS05785	COG0739	heme binding
SmB9_RS05800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SmB9_RS05805	COG1329	Transcriptional regulator
SmB9_RS05830	COG1671	Belongs to the UPF0178 family
SmB9_RS05835	COG0513	Belongs to the DEAD box helicase family
SmB9_RS05845	COG4206	TonB-dependent receptor
SmB9_RS05875	COG4774	siderophore transport
SmB9_RS05880	COG0473	3-isopropylmalate dehydrogenase activity
SmB9_RS05900	COG2851	Citrate transporter
SmB9_RS05915	COG0642	Histidine kinase
SmB9_RS05945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS05955	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS05990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SmB9_RS05995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SmB9_RS06010	COG0494	nUDIX hydrolase
SmB9_RS06045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SmB9_RS06050	COG3386	PFAM SMP-30 Gluconolaconase
SmB9_RS06055	COG1322	Protein conserved in bacteria
SmB9_RS06065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SmB9_RS06070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SmB9_RS06070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SmB9_RS06075	COG1660	Displays ATPase and GTPase activities
SmB9_RS06080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SmB9_RS06085	COG0642	Histidine kinase
SmB9_RS06090	COG0745	RESPONSE REGULATOR receiver
SmB9_RS06095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SmB9_RS06105	COG0484	heat shock protein binding
SmB9_RS06125	COG2166	iron-sulfur cluster assembly
SmB9_RS06175	COG1842	Phage shock protein A
SmB9_RS06180	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SmB9_RS06205	COG2917	probably involved in intracellular septation
SmB9_RS06210	COG0552	protein localization to endoplasmic reticulum
SmB9_RS06215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SmB9_RS06220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SmB9_RS06235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SmB9_RS06240	COG0228	four-way junction DNA binding
SmB9_RS06245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SmB9_RS06250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS06255	COG0336	Belongs to the RNA methyltransferase TrmD family
SmB9_RS06260	COG0335	large ribosomal subunit rRNA binding
SmB9_RS06270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SmB9_RS06275	COG0066	3-isopropylmalate dehydratase activity
SmB9_RS06280	COG0473	3-isopropylmalate dehydrogenase activity
SmB9_RS06290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SmB9_RS06295	COG2814	Major facilitator Superfamily
SmB9_RS06320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SmB9_RS06330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SmB9_RS06340	COG1678	Uncharacterized ACR, COG1678
SmB9_RS06355	COG2205	protein histidine kinase activity
SmB9_RS06360	COG0802	atpase or kinase
SmB9_RS06365	COG3178	'Phosphotransferase
SmB9_RS06370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SmB9_RS06380	COG1074	ATP-dependent DNA helicase activity
SmB9_RS06395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SmB9_RS06400	COG2308	Evidence 4 Homologs of previously reported genes of
SmB9_RS06410	COG1305	Transglutaminase-like
SmB9_RS06435	COG2132	Multicopper oxidase
SmB9_RS06445	COG0789	Transcriptional regulator
SmB9_RS06455	COG0653	protein targeting
SmB9_RS06465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SmB9_RS06470	COG0049	tRNA binding
SmB9_RS06475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SmB9_RS06480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SmB9_RS06485	COG0051	transcription antitermination factor activity, RNA binding
SmB9_RS06490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SmB9_RS06495	COG0088	Forms part of the polypeptide exit tunnel
SmB9_RS06500	COG0089	rRNA binding
SmB9_RS06505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SmB9_RS06510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SmB9_RS06515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SmB9_RS06520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SmB9_RS06525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SmB9_RS06530	COG0255	Belongs to the universal ribosomal protein uL29 family
SmB9_RS06535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SmB9_RS06540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SmB9_RS06545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SmB9_RS06550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SmB9_RS06555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SmB9_RS06560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SmB9_RS06565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SmB9_RS06570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SmB9_RS06575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SmB9_RS06580	COG1841	ribosomal large subunit assembly
SmB9_RS06585	COG0200	Binds to the 23S rRNA
SmB9_RS06590	COG0201	protein transport
SmB9_RS06595	COG0563	adenylate kinase activity
SmB9_RS06620	COG0477	Major facilitator Superfamily
SmB9_RS06625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SmB9_RS06630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SmB9_RS06635	COG0202	RNA polymerase activity
SmB9_RS06640	COG0203	ribosomal protein L17
SmB9_RS06645	COG1454	alcohol dehydrogenase
SmB9_RS06680	COG0519	Catalyzes the synthesis of GMP from XMP
SmB9_RS06680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SmB9_RS06695	COG1393	Belongs to the ArsC family
SmB9_RS06700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SmB9_RS06710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SmB9_RS06715	COG1160	GTP binding
SmB9_RS06725	COG0584	glycerophosphoryl diester phosphodiesterase
SmB9_RS06735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SmB9_RS06760	COG0009	L-threonylcarbamoyladenylate synthase
SmB9_RS06765	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS06775	COG0686	Belongs to the AlaDH PNT family
SmB9_RS06780	COG1522	sequence-specific DNA binding
SmB9_RS06785	COG3158	transport of potassium into the cell
SmB9_RS06800	COG2211	Major facilitator Superfamily
SmB9_RS06805	COG1278	Cold shock
SmB9_RS06820	COG0640	Transcriptional regulator
SmB9_RS06845	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SmB9_RS06865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SmB9_RS06870	COG2095	MarC family integral membrane protein
SmB9_RS06895	COG0137	argininosuccinate synthase activity
SmB9_RS06905	COG1404	Belongs to the peptidase S8 family
SmB9_RS06915	COG2171	N-acyltransferase activity
SmB9_RS06920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SmB9_RS06925	COG1137	ATPase activity
SmB9_RS06930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SmB9_RS06945	COG1253	flavin adenine dinucleotide binding
SmB9_RS06960	COG0181	hydroxymethylbilane synthase activity
SmB9_RS06965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SmB9_RS06970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SmB9_RS06990	COG0501	Belongs to the peptidase M48B family
SmB9_RS07010	COG0138	bifunctional purine biosynthesis protein purh
SmB9_RS07025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SmB9_RS07030	COG1024	Enoyl-CoA hydratase
SmB9_RS07035	COG2133	pyrroloquinoline quinone binding
SmB9_RS07040	COG0779	Required for maturation of 30S ribosomal subunits
SmB9_RS07055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SmB9_RS07060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SmB9_RS07065	COG1435	thymidine kinase activity
SmB9_RS07075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SmB9_RS07080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SmB9_RS07085	COG1185	polyribonucleotide nucleotidyltransferase activity
SmB9_RS07115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SmB9_RS07120	COG0756	dUTP diphosphatase activity
SmB9_RS07125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SmB9_RS07130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SmB9_RS07135	COG2226	methyltransferase
SmB9_RS07140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SmB9_RS07145	COG1024	Enoyl-CoA hydratase
SmB9_RS07155	COG0268	Binds directly to 16S ribosomal RNA
SmB9_RS07160	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SmB9_RS07180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SmB9_RS07185	COG0405	Gamma-glutamyltransferase
SmB9_RS07205	COG0501	Belongs to the peptidase M48B family
SmB9_RS07210	COG4269	membrane
SmB9_RS07215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SmB9_RS07225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SmB9_RS07230	COG1902	pentaerythritol trinitrate reductase activity
SmB9_RS07245	COG2224	Isocitrate lyase
SmB9_RS07255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SmB9_RS07285	COG0438	transferase activity, transferring glycosyl groups
SmB9_RS07290	COG0367	asparagine synthase
SmB9_RS07315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SmB9_RS07340	COG0539	negative regulation of cytoplasmic translation
SmB9_RS07345	COG0776	regulation of translation
SmB9_RS07355	COG0284	orotidine-5'-phosphate decarboxylase activity
SmB9_RS07365	COG0133	tryptophan synthase activity
SmB9_RS07370	COG0159	tryptophan synthase activity
SmB9_RS07375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SmB9_RS07380	COG0285	dihydrofolate synthase activity
SmB9_RS07385	COG2211	Major facilitator Superfamily
SmB9_RS07390	COG4638	Rieske (2fe-2S)
SmB9_RS07395	COG1301	dicarboxylic acid transport
SmB9_RS07405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SmB9_RS07460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SmB9_RS07520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SmB9_RS07530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SmB9_RS07535	COG0706	membrane insertase activity
SmB9_RS07540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SmB9_RS07545	COG0625	glutathione transferase activity
SmB9_RS07550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SmB9_RS07555	COG0165	Argininosuccinate lyase
SmB9_RS07565	COG0019	diaminopimelate decarboxylase activity
SmB9_RS07575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SmB9_RS07580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SmB9_RS07580	COG0596	Alpha beta hydrolase
SmB9_RS07580	COG2226	methyltransferase
SmB9_RS07585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SmB9_RS07590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SmB9_RS07595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SmB9_RS07600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SmB9_RS07605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SmB9_RS07615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SmB9_RS07620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SmB9_RS07625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SmB9_RS07635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SmB9_RS07650	COG0586	Pfam SNARE associated Golgi protein
SmB9_RS07655	COG0189	ligase activity
SmB9_RS07660	COG0792	nuclease activity
SmB9_RS07665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SmB9_RS07675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SmB9_RS07680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SmB9_RS07685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SmB9_RS07690	COG1420	regulation of RNA biosynthetic process
SmB9_RS07695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SmB9_RS07720	COG0443	Heat shock 70 kDa protein
SmB9_RS07725	COG0484	heat shock protein binding
SmB9_RS07730	COG0625	glutathione transferase activity
SmB9_RS07745	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SmB9_RS07750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SmB9_RS07760	COG0793	Belongs to the peptidase S41A family
SmB9_RS07770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SmB9_RS07775	COG0799	negative regulation of ribosome biogenesis
SmB9_RS07780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SmB9_RS07785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SmB9_RS07790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SmB9_RS07795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SmB9_RS07800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SmB9_RS07810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SmB9_RS07815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SmB9_RS07840	COG4771	TonB-dependent receptor
SmB9_RS07850	COG2124	cytochrome p450
SmB9_RS07855	COG1522	sequence-specific DNA binding
SmB9_RS07895	COG0071	Belongs to the small heat shock protein (HSP20) family
SmB9_RS07900	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SmB9_RS07905	COG3387	PFAM Glycoside hydrolase 15-related
SmB9_RS07910	COG1877	trehalose-phosphatase activity
SmB9_RS07930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SmB9_RS07935	COG0081	regulation of translation
SmB9_RS07940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SmB9_RS07945	COG0222	ribosome binding
SmB9_RS07955	COG0477	Major facilitator Superfamily
SmB9_RS07960	COG0085	RNA polymerase activity
SmB9_RS07965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SmB9_RS07985	COG0114	fumarate hydratase activity
SmB9_RS07990	COG5001	Diguanylate cyclase
SmB9_RS07995	COG3706	GGDEF domain
SmB9_RS08000	COG0194	GDP metabolic process
SmB9_RS08005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SmB9_RS08010	COG4770	biotin carboxylase activity
SmB9_RS08035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SmB9_RS08040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SmB9_RS08060	COG0546	phosphoglycolate phosphatase activity
SmB9_RS08070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SmB9_RS08095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SmB9_RS08100	COG1695	Transcriptional regulator
SmB9_RS08110	COG1301	dicarboxylic acid transport
SmB9_RS08115	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS08120	COG4948	Mandelate Racemase Muconate Lactonizing
SmB9_RS08130	COG0583	DNA-binding transcription factor activity
SmB9_RS08135	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS08185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS08190	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS08200	COG4166	transmembrane transport
SmB9_RS08210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SmB9_RS08215	COG4172	Belongs to the ABC transporter superfamily
SmB9_RS08225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS08240	COG2879	small protein
SmB9_RS08245	COG1966	Carbon starvation protein
SmB9_RS08260	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS08275	COG2081	HI0933 family
SmB9_RS08280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SmB9_RS08315	COG0583	DNA-binding transcription factor activity
SmB9_RS08320	COG2814	Major facilitator Superfamily
SmB9_RS08325	COG3104	oligopeptide transport
SmB9_RS08355	COG3246	L-lysine catabolic process to acetate
SmB9_RS08375	COG1802	Transcriptional regulator
SmB9_RS08380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SmB9_RS08385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS08400	COG2271	Major facilitator Superfamily
SmB9_RS08405	COG1228	amidohydrolase
SmB9_RS08410	COG0671	phosphoesterase, PA-phosphatase related
SmB9_RS08415	COG1454	alcohol dehydrogenase
SmB9_RS08435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmB9_RS08460	COG0508	dehydrogenase complex catalyzes the overall conversion of
SmB9_RS08465	COG0022	dehydrogenase e1 component
SmB9_RS08470	COG1448	Aminotransferase
SmB9_RS08475	COG1522	sequence-specific DNA binding
SmB9_RS08510	COG2268	Band 7 protein
SmB9_RS08530	COG0330	HflC and HflK could
SmB9_RS08545	COG0346	lactoylglutathione lyase activity
SmB9_RS08550	COG1946	Acyl-CoA thioesterase
SmB9_RS08555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SmB9_RS08570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SmB9_RS08575	COG3119	arylsulfatase activity
SmB9_RS08585	COG3119	arylsulfatase activity
SmB9_RS08610	COG2200	EAL domain
SmB9_RS08625	COG2205	protein histidine kinase activity
SmB9_RS08625	COG0784	Response regulator, receiver
SmB9_RS08625	COG2198	Histidine kinase
SmB9_RS08635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SmB9_RS08705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SmB9_RS08720	COG0473	3-isopropylmalate dehydrogenase activity
SmB9_RS08730	COG1522	sequence-specific DNA binding
SmB9_RS08735	COG1473	amidohydrolase
SmB9_RS08755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SmB9_RS08775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SmB9_RS08780	COG2423	ornithine cyclodeaminase activity
SmB9_RS08800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS08855	COG3668	Plasmid stabilization system
SmB9_RS08860	COG0431	NADPH-dependent FMN reductase
SmB9_RS08875	COG0251	oxidation-reduction process
SmB9_RS08880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS08890	COG1522	sequence-specific DNA binding
SmB9_RS08900	COG0583	DNA-binding transcription factor activity
SmB9_RS08915	COG0154	amidase activity
SmB9_RS08925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS08930	COG2188	Transcriptional regulator
SmB9_RS08940	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SmB9_RS08945	COG1335	isochorismatase
SmB9_RS08965	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS08975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS08990	COG1054	Belongs to the UPF0176 family
SmB9_RS08995	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SmB9_RS08995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS09020	COG0477	Major facilitator Superfamily
SmB9_RS09025	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS09045	COG4771	TonB-dependent receptor
SmB9_RS09060	COG0339	signal peptide processing
SmB9_RS09065	COG0492	ferredoxin-NADP+ reductase activity
SmB9_RS09075	COG0312	modulator of DNA gyrase
SmB9_RS09080	COG0312	modulator of DNA gyrase
SmB9_RS09105	COG0392	lysyltransferase activity
SmB9_RS09105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SmB9_RS09130	COG0745	RESPONSE REGULATOR receiver
SmB9_RS09135	COG2205	protein histidine kinase activity
SmB9_RS09155	COG4771	TonB-dependent receptor
SmB9_RS09165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SmB9_RS09175	COG3246	L-lysine catabolic process to acetate
SmB9_RS09210	COG4774	siderophore transport
SmB9_RS09255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SmB9_RS09270	COG0446	pyridine nucleotide-disulphide oxidoreductase
SmB9_RS09270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SmB9_RS09305	COG1506	peptidase
SmB9_RS09305	COG0823	Involved in the tonB-independent uptake of proteins
SmB9_RS09305	COG4946	Tricorn protease homolog
SmB9_RS09325	COG2814	Major facilitator Superfamily
SmB9_RS09335	COG1228	amidohydrolase
SmB9_RS09440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SmB9_RS09445	COG3031	protein transport across the cell outer membrane
SmB9_RS09455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SmB9_RS09465	COG2165	general secretion pathway protein
SmB9_RS09485	COG3156	type II secretion system protein K
SmB9_RS09515	COG0175	sulfate reduction
SmB9_RS09530	COG0534	Mate efflux family protein
SmB9_RS09550	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS09560	COG0783	Belongs to the Dps family
SmB9_RS09565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SmB9_RS09590	COG1192	Involved in chromosome partitioning
SmB9_RS09610	COG5001	Diguanylate cyclase
SmB9_RS09640	COG0784	Response regulator, receiver
SmB9_RS09645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SmB9_RS09655	COG0557	exoribonuclease II activity
SmB9_RS09665	COG3609	addiction module antidote protein, CC2985 family
SmB9_RS09680	COG1754	DNA topoisomerase type I activity
SmB9_RS09680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SmB9_RS09685	COG1393	Belongs to the ArsC family
SmB9_RS09695	COG0439	Biotin carboxylase
SmB9_RS09700	COG0511	ligase activity, forming carbon-carbon bonds
SmB9_RS09705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SmB9_RS09730	COG0494	nUDIX hydrolase
SmB9_RS09735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SmB9_RS09735	COG0674	pyruvate-flavodoxin oxidoreductase activity
SmB9_RS09740	COG1013	pyruvate-flavodoxin oxidoreductase activity
SmB9_RS09775	COG0415	Belongs to the DNA photolyase family
SmB9_RS09780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SmB9_RS09790	COG1301	dicarboxylic acid transport
SmB9_RS09805	COG2967	ApaG domain
SmB9_RS09820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SmB9_RS09825	COG0842	Transport permease protein
SmB9_RS09835	COG0653	protein targeting
SmB9_RS09840	COG3243	poly(R)-hydroxyalkanoic acid synthase
SmB9_RS09845	COG0436	Aminotransferase
SmB9_RS09855	COG1494	fructose-1,6-bisphosphatase
SmB9_RS09860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SmB9_RS09870	COG3634	alkyl hydroperoxide reductase activity
SmB9_RS09890	COG4650	regulator
SmB9_RS09905	COG1690	Belongs to the RtcB family
SmB9_RS09910	COG0430	RNA-3'-phosphate cyclase activity
SmB9_RS09915	COG1741	Belongs to the pirin family
SmB9_RS09920	COG0583	DNA-binding transcription factor activity
SmB9_RS09930	COG2814	Major facilitator Superfamily
SmB9_RS09940	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SmB9_RS09955	COG1335	isochorismatase
SmB9_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS09970	COG4771	TonB-dependent receptor
SmB9_RS09980	COG0655	NAD(P)H dehydrogenase (quinone) activity
SmB9_RS09985	COG0596	Alpha beta hydrolase
SmB9_RS09995	COG1414	Transcriptional regulator
SmB9_RS10000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS10015	COG0582	viral genome integration into host DNA
SmB9_RS10020	COG0583	DNA-binding transcription factor activity
SmB9_RS10035	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS10040	COG0657	acetylesterase activity
SmB9_RS10050	COG1396	sequence-specific DNA binding
SmB9_RS10070	COG1228	amidohydrolase
SmB9_RS10080	COG2423	ornithine cyclodeaminase activity
SmB9_RS10085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS10090	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS10130	COG4773	Receptor
SmB9_RS10170	COG4638	Rieske (2fe-2S)
SmB9_RS10190	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS10205	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SmB9_RS10230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmB9_RS10240	COG1538	Outer membrane efflux protein
SmB9_RS10250	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS10255	COG1506	peptidase
SmB9_RS10255	COG0823	Involved in the tonB-independent uptake of proteins
SmB9_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS10275	COG3246	L-lysine catabolic process to acetate
SmB9_RS10295	COG3104	oligopeptide transport
SmB9_RS10300	COG2207	Transcriptional regulator
SmB9_RS10315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SmB9_RS10350	COG4771	TonB-dependent receptor
SmB9_RS10395	COG4771	TonB-dependent receptor
SmB9_RS10415	COG4206	TonB-dependent receptor
SmB9_RS10425	COG1228	amidohydrolase
SmB9_RS10440	COG1396	sequence-specific DNA binding
SmB9_RS10455	COG1522	sequence-specific DNA binding
SmB9_RS10480	COG0531	amino acid
SmB9_RS10500	COG0745	RESPONSE REGULATOR receiver
SmB9_RS10530	COG1592	Rubrerythrin
SmB9_RS10555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SmB9_RS10565	COG4638	Rieske (2fe-2S)
SmB9_RS10585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SmB9_RS10590	COG0564	pseudouridine synthase activity
SmB9_RS10600	COG1278	Cold shock
SmB9_RS10610	COG2198	Histidine kinase
SmB9_RS10610	COG0784	Response regulator, receiver
SmB9_RS10610	COG0643	Histidine kinase
SmB9_RS10615	COG0835	chemotaxis
SmB9_RS10645	COG3023	N-Acetylmuramoyl-L-alanine amidase
SmB9_RS10660	COG1213	nucleotidyl transferase
SmB9_RS10670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SmB9_RS10685	COG0789	Transcriptional regulator
SmB9_RS10695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SmB9_RS10710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS10715	COG4774	siderophore transport
SmB9_RS10720	COG1024	Enoyl-CoA hydratase
SmB9_RS10740	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS10745	COG2211	Major facilitator Superfamily
SmB9_RS10755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SmB9_RS10765	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS10775	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS10780	COG3268	Saccharopine dehydrogenase
SmB9_RS10805	COG0604	alcohol dehydrogenase
SmB9_RS10810	COG0385	Bile acid
SmB9_RS10825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SmB9_RS10835	COG1846	Transcriptional regulator
SmB9_RS10845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SmB9_RS10850	COG1917	Cupin 2, conserved barrel domain protein
SmB9_RS10855	COG5285	phytanoyl-CoA dioxygenase
SmB9_RS10860	COG0527	aspartate kinase activity
SmB9_RS10870	COG0477	Major facilitator Superfamily
SmB9_RS10885	COG2072	flavoprotein involved in K transport
SmB9_RS10890	COG4771	TonB-dependent receptor
SmB9_RS10895	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SmB9_RS10900	COG2124	cytochrome p450
SmB9_RS10905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS10925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SmB9_RS10940	COG0488	(ABC) transporter
SmB9_RS10945	COG0840	transmembrane signaling receptor activity
SmB9_RS10960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SmB9_RS10970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SmB9_RS10975	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SmB9_RS10990	COG0482	sulfurtransferase activity
SmB9_RS11015	COG0259	pyridoxamine-phosphate oxidase activity
SmB9_RS11035	COG0798	PFAM Bile acid sodium symporter
SmB9_RS11040	COG0484	heat shock protein binding
SmB9_RS11050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SmB9_RS11055	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SmB9_RS11060	COG1254	Belongs to the acylphosphatase family
SmB9_RS11065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SmB9_RS11075	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SmB9_RS11080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SmB9_RS11090	COG1304	FMN binding
SmB9_RS11095	COG5001	Diguanylate cyclase
SmB9_RS11110	COG2311	Membrane
SmB9_RS11115	COG3474	cytochrome
SmB9_RS11130	COG1192	Involved in chromosome partitioning
SmB9_RS11140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SmB9_RS11145	COG0039	L-malate dehydrogenase activity
SmB9_RS11150	COG0045	succinate-CoA ligase (ADP-forming) activity
SmB9_RS11155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SmB9_RS11160	COG0567	Dehydrogenase, E1 component
SmB9_RS11165	COG0508	dehydrogenase complex catalyzes the overall conversion of
SmB9_RS11175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SmB9_RS11185	COG0616	signal peptide processing
SmB9_RS11190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SmB9_RS11195	COG0459	protein refolding
SmB9_RS11205	COG2853	Lipoprotein
SmB9_RS11225	COG1410	methionine synthase
SmB9_RS11225	COG0646	methionine synthase
SmB9_RS11235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SmB9_RS11250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SmB9_RS11255	COG2084	Dehydrogenase
SmB9_RS11260	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SmB9_RS11270	COG0113	porphobilinogen synthase activity
SmB9_RS11275	COG2258	MOSC domain
SmB9_RS11280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SmB9_RS11290	COG1024	Enoyl-CoA hydratase
SmB9_RS11305	COG0156	8-amino-7-oxononanoate synthase activity
SmB9_RS11320	COG0698	ribose 5-phosphate isomerase
SmB9_RS11325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SmB9_RS11330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SmB9_RS11335	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SmB9_RS11345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SmB9_RS11380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SmB9_RS11390	COG0028	Belongs to the TPP enzyme family
SmB9_RS11400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SmB9_RS11440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SmB9_RS11445	COG0540	Belongs to the ATCase OTCase family
SmB9_RS11455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SmB9_RS11465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS11470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SmB9_RS11475	COG0154	amidase activity
SmB9_RS11485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SmB9_RS11515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmB9_RS11520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmB9_RS11540	COG1196	nuclear chromosome segregation
SmB9_RS11550	COG0356	it plays a direct role in the translocation of protons across the membrane
SmB9_RS11560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SmB9_RS11575	COG3153	acetyltransferase
SmB9_RS11595	COG0714	Associated with various cellular activities
SmB9_RS11605	COG0494	nUDIX hydrolase
SmB9_RS11610	COG0617	tRNA 3'-terminal CCA addition
SmB9_RS11615	COG5001	Diguanylate cyclase
SmB9_RS11625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SmB9_RS11630	COG0583	DNA-binding transcription factor activity
SmB9_RS11635	COG1381	Involved in DNA repair and RecF pathway recombination
SmB9_RS11645	COG0730	response to heat
SmB9_RS11650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SmB9_RS11655	COG0640	Transcriptional regulator
SmB9_RS11670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SmB9_RS11675	COG0571	ribonuclease III activity
SmB9_RS11685	COG0166	Belongs to the GPI family
SmB9_RS11695	COG1217	gtp-binding protein TYPA
SmB9_RS11700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS11720	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SmB9_RS11730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SmB9_RS11735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SmB9_RS11745	COG2986	histidine ammonia-lyase
SmB9_RS11770	COG0772	Belongs to the SEDS family
SmB9_RS11775	COG0768	penicillin binding
SmB9_RS11795	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SmB9_RS11805	COG0531	amino acid
SmB9_RS11810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SmB9_RS11810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SmB9_RS11815	COG0501	Belongs to the peptidase M48B family
SmB9_RS11820	COG1530	ribonuclease E activity
SmB9_RS11825	COG0860	N-Acetylmuramoyl-L-alanine amidase
SmB9_RS11840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SmB9_RS11855	COG0626	cystathionine gamma-synthase activity
SmB9_RS11860	COG2897	thiosulfate sulfurtransferase activity
SmB9_RS11865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SmB9_RS11870	COG0602	queuosine metabolic process
SmB9_RS11875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SmB9_RS11890	COG0187	DNA topoisomerase II activity
SmB9_RS11910	COG0174	glutamine synthetase
SmB9_RS11915	COG0347	Belongs to the P(II) protein family
SmB9_RS11930	COG0729	surface antigen
SmB9_RS11975	COG0297	glycogen (starch) synthase activity
SmB9_RS11990	COG0668	transmembrane transport
SmB9_RS12010	COG0183	Belongs to the thiolase family
SmB9_RS12020	COG0837	glucose binding
SmB9_RS12030	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS12035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmB9_RS12060	COG1250	3-hydroxyacyl-CoA dehydrogenase
SmB9_RS12065	COG0477	Major facilitator Superfamily
SmB9_RS12070	COG3246	L-lysine catabolic process to acetate
SmB9_RS12100	COG3609	addiction module antidote protein, CC2985 family
SmB9_RS12105	COG3668	Plasmid stabilization system
SmB9_RS12120	COG1429	ligase activity, forming nitrogen-metal bonds
SmB9_RS12135	COG4771	TonB-dependent receptor
SmB9_RS12170	COG0457	Tetratricopeptide repeat
SmB9_RS12180	COG0582	viral genome integration into host DNA
SmB9_RS12190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SmB9_RS12205	COG0525	valine-tRNA ligase activity
SmB9_RS12210	COG0354	folic acid binding
SmB9_RS12215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SmB9_RS12220	COG0477	Major facilitator Superfamily
SmB9_RS12225	COG0412	Dienelactone hydrolase
SmB9_RS12250	COG5507	3-demethylubiquinone-9 3-methyltransferase
SmB9_RS12260	COG2824	Alkylphosphonate utilization operon protein PhnA
SmB9_RS12295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SmB9_RS12360	COG1959	2 iron, 2 sulfur cluster binding
SmB9_RS12365	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SmB9_RS12370	COG1199	ATP-dependent helicase activity
SmB9_RS12370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SmB9_RS12390	COG0640	Transcriptional regulator
SmB9_RS12400	COG0556	nucleotide-excision repair
SmB9_RS12415	COG1473	amidohydrolase
SmB9_RS12435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SmB9_RS12435	COG4651	solute:proton antiporter activity
SmB9_RS12450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SmB9_RS12450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SmB9_RS12460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SmB9_RS12480	COG3609	addiction module antidote protein, CC2985 family
SmB9_RS12490	COG1872	DUF167
SmB9_RS12515	COG4771	TonB-dependent receptor
SmB9_RS12520	COG1506	peptidase
SmB9_RS12520	COG0823	Involved in the tonB-independent uptake of proteins
SmB9_RS12530	COG1902	pentaerythritol trinitrate reductase activity
SmB9_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS12545	COG1024	Enoyl-CoA hydratase
SmB9_RS12550	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS12565	COG3483	tryptophan 2,3-dioxygenase activity
SmB9_RS12580	COG0251	oxidation-reduction process
SmB9_RS12600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SmB9_RS12620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SmB9_RS12625	COG0126	phosphoglycerate kinase activity
SmB9_RS12635	COG1830	Aldolase
SmB9_RS12640	COG0352	thiamine-phosphate diphosphorylase activity
SmB9_RS12650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SmB9_RS12655	COG0483	inositol monophosphate 1-phosphatase activity
SmB9_RS12660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmB9_RS12665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmB9_RS12670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmB9_RS12675	COG0649	NAD binding
SmB9_RS12700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SmB9_RS12710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmB9_RS12720	COG0713	ATP synthesis coupled electron transport
SmB9_RS12735	COG1007	ATP synthesis coupled electron transport
SmB9_RS12745	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SmB9_RS12780	COG1260	myo-inositol-1-phosphate synthase
SmB9_RS12785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SmB9_RS12800	COG2205	protein histidine kinase activity
SmB9_RS12810	COG0372	Belongs to the citrate synthase family
SmB9_RS12815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SmB9_RS12820	COG2333	competence protein COMEC
SmB9_RS12820	COG0658	competence protein
SmB9_RS12830	COG1230	cation diffusion facilitator family transporter
SmB9_RS12835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SmB9_RS12840	COG0303	'Molybdopterin
SmB9_RS12845	COG0315	cyclic pyranopterin monophosphate synthase activity
SmB9_RS12855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SmB9_RS12865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SmB9_RS12870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SmB9_RS12875	COG0149	triose-phosphate isomerase activity
SmB9_RS12880	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
SmB9_RS12885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SmB9_RS12890	COG0504	CTP synthase activity
SmB9_RS12900	COG0662	Cupin 2, conserved barrel domain protein
SmB9_RS12900	COG2207	Transcriptional regulator
SmB9_RS12905	COG0442	prolyl-tRNA aminoacylation
SmB9_RS12915	COG1136	(ABC) transporter
SmB9_RS12935	COG1024	Enoyl-CoA hydratase
SmB9_RS12945	COG0129	dihydroxy-acid dehydratase activity
SmB9_RS12950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SmB9_RS12950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SmB9_RS12955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SmB9_RS12985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SmB9_RS13020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SmB9_RS13035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SmB9_RS13050	COG0505	Belongs to the CarA family
SmB9_RS13065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SmB9_RS13080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SmB9_RS13090	COG3474	cytochrome
SmB9_RS13115	COG0148	phosphopyruvate hydratase activity
SmB9_RS13125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SmB9_RS13130	COG0508	dehydrogenase complex catalyzes the overall conversion of
SmB9_RS13130	COG0022	dehydrogenase e1 component
SmB9_RS13135	COG0508	dehydrogenase complex catalyzes the overall conversion of
SmB9_RS13145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SmB9_RS13150	COG0288	reversible hydration of carbon dioxide
SmB9_RS13155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SmB9_RS13160	COG2867	negative regulation of translational initiation
SmB9_RS13165	COG1546	Belongs to the CinA family
SmB9_RS13165	COG1058	Belongs to the CinA family
SmB9_RS13175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SmB9_RS13175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SmB9_RS13190	COG2204	response regulator
SmB9_RS13195	COG5000	phosphorelay sensor kinase activity
SmB9_RS13200	COG2204	response regulator
SmB9_RS13205	COG1923	regulation of RNA biosynthetic process
SmB9_RS13210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SmB9_RS13215	COG3956	TIGRFAM MazG family protein
SmB9_RS13240	COG0321	lipoyl(octanoyl) transferase activity
SmB9_RS13240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SmB9_RS13245	COG0084	hydrolase, TatD family'
SmB9_RS13250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SmB9_RS13255	COG0470	DNA polymerase III
SmB9_RS13260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SmB9_RS13265	COG1686	Belongs to the peptidase S11 family
SmB9_RS13280	COG2951	lytic endotransglycosylase activity
SmB9_RS13290	COG0582	viral genome integration into host DNA
SmB9_RS13300	COG3311	Transcriptional regulator
SmB9_RS13325	COG0861	Integral membrane protein TerC family
SmB9_RS13335	COG0302	gtp cyclohydrolase
SmB9_RS13340	COG4566	intracellular signal transduction
SmB9_RS13345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SmB9_RS13365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SmB9_RS13385	COG0405	Gamma-glutamyltransferase
SmB9_RS13405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SmB9_RS13410	COG2814	Major facilitator Superfamily
SmB9_RS13445	COG0346	lactoylglutathione lyase activity
SmB9_RS13450	COG0254	rRNA binding
SmB9_RS13470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SmB9_RS13475	COG0583	DNA-binding transcription factor activity
SmB9_RS13480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SmB9_RS13485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SmB9_RS13495	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS13510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SmB9_RS13520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SmB9_RS13525	COG0750	zinc metalloprotease
SmB9_RS13530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SmB9_RS13540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SmB9_RS13545	COG0233	cytoplasmic translational termination
SmB9_RS13550	COG0528	UMP kinase activity
SmB9_RS13555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SmB9_RS13560	COG0052	Belongs to the universal ribosomal protein uS2 family
SmB9_RS13570	COG2954	triphosphatase activity
SmB9_RS13580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SmB9_RS13595	COG1573	uracil-dna glycosylase
SmB9_RS13600	COG0521	Mo-molybdopterin cofactor biosynthetic process
SmB9_RS13615	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS13625	COG0688	phosphatidylethanolamine metabolic process
SmB9_RS13630	COG0538	isocitrate dehydrogenase activity
SmB9_RS13640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SmB9_RS13645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SmB9_RS13650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SmB9_RS13660	COG2814	Major facilitator Superfamily
SmB9_RS13670	COG1686	Belongs to the peptidase S11 family
SmB9_RS13675	COG1250	3-hydroxyacyl-CoA dehydrogenase
SmB9_RS13675	COG1024	Enoyl-CoA hydratase
SmB9_RS13680	COG0183	Belongs to the thiolase family
SmB9_RS13685	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS13695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SmB9_RS13700	COG0668	transmembrane transport
SmB9_RS13705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SmB9_RS13710	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS13740	COG0745	RESPONSE REGULATOR receiver
SmB9_RS13745	COG3158	transport of potassium into the cell
SmB9_RS13765	COG0242	peptide deformylase activity
SmB9_RS13770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SmB9_RS13775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SmB9_RS13780	COG0101	tRNA pseudouridine synthase activity
SmB9_RS13790	COG0367	asparagine synthase
SmB9_RS13815	COG3267	Type II secretory pathway component ExeA
SmB9_RS13815	COG3409	Peptidoglycan-binding domain 1 protein
SmB9_RS13890	COG1446	asparaginase
SmB9_RS13895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SmB9_RS13915	COG2226	methyltransferase
SmB9_RS13920	COG0463	Glycosyl transferase, family 2
SmB9_RS13935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SmB9_RS13940	COG1573	uracil-dna glycosylase
SmB9_RS13955	COG2957	Belongs to the agmatine deiminase family
SmB9_RS13960	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SmB9_RS14005	COG0488	(ABC) transporter
SmB9_RS14010	COG4774	siderophore transport
SmB9_RS14015	COG3128	pkhd-type hydroxylase
SmB9_RS14020	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SmB9_RS14025	COG1477	protein flavinylation
SmB9_RS14045	COG1132	(ABC) transporter
SmB9_RS14055	COG0861	Integral membrane protein TerC family
SmB9_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS14065	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS14110	COG0322	excinuclease ABC activity
SmB9_RS14115	COG0625	glutathione transferase activity
SmB9_RS14135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SmB9_RS14140	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SmB9_RS14145	COG0314	molybdopterin synthase activity
SmB9_RS14150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SmB9_RS14165	COG0583	DNA-binding transcription factor activity
SmB9_RS14170	COG0492	ferredoxin-NADP+ reductase activity
SmB9_RS14175	COG2205	protein histidine kinase activity
SmB9_RS14180	COG1522	sequence-specific DNA binding
SmB9_RS14190	COG2814	Major facilitator Superfamily
SmB9_RS14195	COG1250	3-hydroxyacyl-CoA dehydrogenase
SmB9_RS14195	COG1024	Enoyl-CoA hydratase
SmB9_RS14240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SmB9_RS14245	COG0740	serine-type endopeptidase activity
SmB9_RS14250	COG0544	peptidyl-prolyl cis-trans isomerase activity
SmB9_RS14260	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SmB9_RS14265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SmB9_RS14280	COG1324	tolerance protein
SmB9_RS14325	COG0776	regulation of translation
SmB9_RS14330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SmB9_RS14335	COG0416	fatty acid biosynthetic process
SmB9_RS14340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SmB9_RS14345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SmB9_RS14365	COG2733	membrane
SmB9_RS14380	COG2261	transglycosylase associated protein
SmB9_RS14385	COG2968	Membrane
SmB9_RS14390	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS14395	COG0183	Belongs to the thiolase family
SmB9_RS14400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SmB9_RS14405	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SmB9_RS14410	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS14420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SmB9_RS14430	COG0583	DNA-binding transcription factor activity
SmB9_RS14435	COG1612	heme a metabolic process
SmB9_RS14440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SmB9_RS14445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SmB9_RS14465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SmB9_RS14470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SmB9_RS14480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SmB9_RS14530	COG2204	response regulator
SmB9_RS14535	COG4191	Histidine kinase
SmB9_RS14540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SmB9_RS14545	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SmB9_RS14545	COG0662	Cupin 2, conserved barrel domain protein
SmB9_RS14555	COG0582	viral genome integration into host DNA
SmB9_RS14590	COG3609	addiction module antidote protein, CC2985 family
SmB9_RS14610	COG2176	DNA-directed DNA polymerase activity
SmB9_RS14620	COG4227	nucleotidyltransferase activity
SmB9_RS14630	COG3344	reverse transcriptase
SmB9_RS14650	COG0739	heme binding
SmB9_RS14650	COG0741	lytic transglycosylase activity
SmB9_RS14650	COG1196	nuclear chromosome segregation
SmB9_RS14675	COG4771	TonB-dependent receptor
SmB9_RS14680	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS14685	COG0477	Major facilitator Superfamily
SmB9_RS14720	COG0776	regulation of translation
SmB9_RS14745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SmB9_RS14765	COG4977	sequence-specific DNA binding
SmB9_RS14765	COG1917	Cupin 2, conserved barrel domain protein
SmB9_RS14770	COG4772	TonB-dependent receptor
SmB9_RS14790	COG0156	8-amino-7-oxononanoate synthase activity
SmB9_RS14795	COG0402	S-adenosylhomocysteine deaminase activity
SmB9_RS14800	COG1228	amidohydrolase
SmB9_RS14805	COG0582	viral genome integration into host DNA
SmB9_RS14815	COG1187	pseudouridine synthase activity
SmB9_RS14820	COG0742	ribosomal rna small subunit methyltransferase
SmB9_RS14855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SmB9_RS14860	COG0497	DNA recombination
SmB9_RS14865	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SmB9_RS14870	COG0438	transferase activity, transferring glycosyl groups
SmB9_RS14880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SmB9_RS14885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SmB9_RS14890	COG1862	Preprotein translocase
SmB9_RS14900	COG3273	potassium ion transport
SmB9_RS14900	COG0471	metal ion transport
SmB9_RS14910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmB9_RS14920	COG0842	Transport permease protein
SmB9_RS14925	COG1131	(ABC) transporter
SmB9_RS14935	COG2195	Cleaves the N-terminal amino acid of tripeptides
SmB9_RS14940	COG1309	transcriptional regulator
SmB9_RS14945	COG0531	amino acid
SmB9_RS14955	COG0457	Tetratricopeptide repeat
SmB9_RS14965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS14970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SmB9_RS14975	COG0174	glutamine synthetase
SmB9_RS14980	COG1278	Cold shock
SmB9_RS15010	COG1177	transmembrane transport
SmB9_RS15015	COG3842	ATPase activity
SmB9_RS15040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SmB9_RS15070	COG0142	geranyltranstransferase activity
SmB9_RS15075	COG1605	Chorismate mutase
SmB9_RS15075	COG0287	Prephenate dehydrogenase
SmB9_RS15100	COG1482	cell wall glycoprotein biosynthetic process
SmB9_RS15110	COG2972	Histidine kinase
SmB9_RS15115	COG3279	Response regulator of the LytR AlgR family
SmB9_RS15140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SmB9_RS15165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SmB9_RS15175	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SmB9_RS15180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SmB9_RS15185	COG2321	neutral zinc metallopeptidase
SmB9_RS15300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SmB9_RS15360	COG3590	peptidase
SmB9_RS15375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SmB9_RS15380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SmB9_RS15385	COG0741	lytic transglycosylase activity
SmB9_RS15405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SmB9_RS15410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SmB9_RS15420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SmB9_RS15430	COG0628	permease
SmB9_RS15440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SmB9_RS15455	COG0105	UTP biosynthetic process
SmB9_RS15465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SmB9_RS15475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SmB9_RS15480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SmB9_RS15485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SmB9_RS15495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SmB9_RS15495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SmB9_RS15510	COG5443	negative regulation of bacterial-type flagellum assembly
SmB9_RS15515	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SmB9_RS15520	COG4149	molybdate abc transporter
SmB9_RS15525	COG0725	ABC transporter, periplasmic molybdate-binding protein
SmB9_RS15560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SmB9_RS15580	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SmB9_RS15610	COG0488	(ABC) transporter
SmB9_RS15625	COG1696	Membrane protein involved in D-alanine export
SmB9_RS15630	COG0436	Aminotransferase
SmB9_RS15680	COG1764	response to oxidative stress
SmB9_RS15685	COG0431	NADPH-dependent FMN reductase
SmB9_RS15705	COG0596	Alpha beta hydrolase
SmB9_RS15710	COG0596	Alpha beta hydrolase
SmB9_RS15715	COG1335	isochorismatase
SmB9_RS15740	COG2070	2-Nitropropane dioxygenase
SmB9_RS15745	COG1942	4-Oxalocrotonate Tautomerase
SmB9_RS15760	COG0596	Alpha beta hydrolase
SmB9_RS15770	COG4566	intracellular signal transduction
SmB9_RS15795	COG4191	Histidine kinase
SmB9_RS15800	COG4191	Histidine kinase
SmB9_RS15805	COG4771	TonB-dependent receptor
SmB9_RS15825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SmB9_RS15860	COG3311	Transcriptional regulator
SmB9_RS15870	COG1475	DNA binding
SmB9_RS15900	COG0583	DNA-binding transcription factor activity
SmB9_RS15905	COG0702	epimerase
SmB9_RS15920	COG0582	viral genome integration into host DNA
SmB9_RS15930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SmB9_RS15960	COG1846	Transcriptional regulator
SmB9_RS15985	COG1104	cysteine desulfurase activity
SmB9_RS15995	COG2945	thiolester hydrolase activity
SmB9_RS16000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SmB9_RS16005	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SmB9_RS16010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SmB9_RS16025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SmB9_RS16030	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SmB9_RS16035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SmB9_RS16055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SmB9_RS16065	COG3706	GGDEF domain
SmB9_RS16065	COG4251	negative regulation of phosphorylation
SmB9_RS16065	COG2203	Gaf domain
SmB9_RS16065	COG5001	Diguanylate cyclase
SmB9_RS16070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SmB9_RS16075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SmB9_RS16130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SmB9_RS16165	COG0556	nucleotide-excision repair
SmB9_RS16170	COG4227	nucleotidyltransferase activity
SmB9_RS16195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SmB9_RS16205	COG5489	Protein of unknown function (DUF736)
SmB9_RS16230	COG2197	response regulator
SmB9_RS16235	COG4566	intracellular signal transduction
SmB9_RS16260	COG0367	asparagine synthase
SmB9_RS16265	COG1506	peptidase
SmB9_RS16265	COG0823	Involved in the tonB-independent uptake of proteins
SmB9_RS16290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS16310	COG1522	sequence-specific DNA binding
SmB9_RS16315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SmB9_RS16320	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS16355	COG1024	Enoyl-CoA hydratase
SmB9_RS16360	COG1250	3-hydroxyacyl-CoA dehydrogenase
SmB9_RS16365	COG0183	Belongs to the thiolase family
SmB9_RS16370	COG0667	Aldo Keto reductase
SmB9_RS16380	COG2186	Transcriptional regulator
SmB9_RS16390	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SmB9_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS16420	COG3618	amidohydrolase
SmB9_RS16445	COG4638	Rieske (2fe-2S)
SmB9_RS16485	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS16505	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS16520	COG1228	amidohydrolase
SmB9_RS16555	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS16565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SmB9_RS16590	COG3609	addiction module antidote protein, CC2985 family
SmB9_RS16630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SmB9_RS16635	COG0583	DNA-binding transcription factor activity
SmB9_RS16640	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS16645	COG4771	TonB-dependent receptor
SmB9_RS16660	COG4251	negative regulation of phosphorylation
SmB9_RS16670	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS16695	COG1228	amidohydrolase
SmB9_RS16710	COG4774	siderophore transport
SmB9_RS16720	COG0531	amino acid
SmB9_RS16745	COG1741	Belongs to the pirin family
SmB9_RS16750	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS16770	COG0037	tRNA processing
SmB9_RS16790	COG2070	2-Nitropropane dioxygenase
SmB9_RS16800	COG0612	Peptidase, M16
SmB9_RS16825	COG1201	RNA secondary structure unwinding
SmB9_RS16850	COG3275	phosphorelay sensor kinase activity
SmB9_RS16855	COG3279	Response regulator of the LytR AlgR family
SmB9_RS16860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SmB9_RS16865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS16890	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SmB9_RS16910	COG0542	response to heat
SmB9_RS16930	COG4771	TonB-dependent receptor
SmB9_RS16940	COG1570	exodeoxyribonuclease VII activity
SmB9_RS16945	COG0151	Belongs to the GarS family
SmB9_RS16960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SmB9_RS16975	COG1253	flavin adenine dinucleotide binding
SmB9_RS16985	COG2885	chlorophyll binding
SmB9_RS16990	COG1234	tRNA 3'-trailer cleavage
SmB9_RS16995	COG2226	methyltransferase
SmB9_RS17000	COG5642	Protein of unknown function (DUF2384)
SmB9_RS17010	COG0667	Aldo Keto reductase
SmB9_RS17015	COG1053	succinate dehydrogenase
SmB9_RS17020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SmB9_RS17050	COG3321	synthase
SmB9_RS17050	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS17050	COG0604	alcohol dehydrogenase
SmB9_RS17055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SmB9_RS17060	COG0583	DNA-binding transcription factor activity
SmB9_RS17065	COG0730	response to heat
SmB9_RS17070	COG1045	serine acetyltransferase
SmB9_RS17080	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS17085	COG0745	RESPONSE REGULATOR receiver
SmB9_RS17090	COG0704	Plays a role in the regulation of phosphate uptake
SmB9_RS17095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SmB9_RS17105	COG0573	inorganic phosphate transmembrane transporter activity
SmB9_RS17110	COG5002	protein histidine kinase activity
SmB9_RS17135	COG0546	phosphoglycolate phosphatase activity
SmB9_RS17140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SmB9_RS17145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SmB9_RS17170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SmB9_RS17185	COG0481	GTPase activity
SmB9_RS17195	COG0564	pseudouridine synthase activity
SmB9_RS17210	COG1758	RNA polymerase activity
SmB9_RS17215	COG3384	dioxygenase
SmB9_RS17225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SmB9_RS17230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SmB9_RS17235	COG0736	holo-[acyl-carrier-protein] synthase activity
SmB9_RS17240	COG0681	Belongs to the peptidase S26 family
SmB9_RS17250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SmB9_RS17265	COG1918	ferrous iron import across plasma membrane
SmB9_RS17265	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SmB9_RS17270	COG0629	single-stranded DNA binding
SmB9_RS17300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SmB9_RS17305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SmB9_RS17310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SmB9_RS17325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SmB9_RS17325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SmB9_RS17340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SmB9_RS17350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SmB9_RS17355	COG0758	DNA mediated transformation
SmB9_RS17360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SmB9_RS17385	COG1278	Cold shock
SmB9_RS17400	COG2068	MobA-Related Protein
SmB9_RS17410	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS17420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SmB9_RS17425	COG0156	8-amino-7-oxononanoate synthase activity
SmB9_RS17470	COG0456	acetyltransferase
SmB9_RS17480	COG0316	Belongs to the HesB IscA family
SmB9_RS17485	COG0739	heme binding
SmB9_RS17490	COG2833	Protein of unknown function (DUF455)
SmB9_RS17495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SmB9_RS17500	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SmB9_RS17510	COG0784	Response regulator, receiver
SmB9_RS17525	COG0805	protein transport
SmB9_RS17530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SmB9_RS17535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SmB9_RS17540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SmB9_RS17545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SmB9_RS17550	COG1472	Belongs to the glycosyl hydrolase 3 family
SmB9_RS17560	COG0018	arginyl-trna synthetase
SmB9_RS17565	COG3706	GGDEF domain
SmB9_RS17570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SmB9_RS17580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SmB9_RS17585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SmB9_RS17590	COG0849	cell division
SmB9_RS17595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SmB9_RS17600	COG1181	Belongs to the D-alanine--D-alanine ligase family
SmB9_RS17605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SmB9_RS17610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SmB9_RS17615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SmB9_RS17625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SmB9_RS17630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SmB9_RS17635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SmB9_RS17640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SmB9_RS17655	COG0275	rRNA processing
SmB9_RS17660	COG2001	Belongs to the MraZ family
SmB9_RS17670	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS17685	COG0205	6-phosphofructokinase activity
SmB9_RS17700	COG2239	Acts as a magnesium transporter
SmB9_RS17715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SmB9_RS17725	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS17730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SmB9_RS17745	COG0318	PFAM AMP-dependent synthetase and ligase
SmB9_RS17750	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS17755	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS17760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SmB9_RS17775	COG1496	oxidoreductase activity
SmB9_RS17785	COG0519	Catalyzes the synthesis of GMP from XMP
SmB9_RS17790	COG5265	(ABC) transporter
SmB9_RS17805	COG0305	Participates in initiation and elongation during chromosome replication
SmB9_RS17810	COG1752	Esterase of the alpha-beta hydrolase superfamily
SmB9_RS17820	COG0215	cysteine-tRNA ligase activity
SmB9_RS17825	COG1286	toxin biosynthetic process
SmB9_RS17835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SmB9_RS17840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SmB9_RS17855	COG2020	methyltransferase activity
SmB9_RS17875	COG0251	oxidation-reduction process
SmB9_RS17880	COG1960	acyl-CoA dehydrogenase activity
SmB9_RS17885	COG2363	Small membrane protein
SmB9_RS17890	COG2130	NADP-dependent
SmB9_RS17905	COG0235	Class ii aldolase
SmB9_RS17910	COG3540	Alkaline phosphatase
SmB9_RS17915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SmB9_RS17930	COG4974	Belongs to the 'phage' integrase family
SmB9_RS17935	COG0825	malonyl-CoA metabolic process
SmB9_RS17965	COG2814	Major facilitator Superfamily
SmB9_RS17985	COG1024	Enoyl-CoA hydratase
SmB9_RS17990	COG2350	Protein conserved in bacteria
SmB9_RS18000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SmB9_RS18025	COG3916	Acyl-homoserine-lactone synthase
SmB9_RS18035	COG0590	tRNA wobble adenosine to inosine editing
SmB9_RS18045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SmB9_RS18050	COG0287	Prephenate dehydrogenase
SmB9_RS18075	COG2884	Cell division ATP-binding protein ftsE
SmB9_RS18085	COG4166	transmembrane transport
SmB9_RS18090	COG0183	Belongs to the thiolase family
SmB9_RS18100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SmB9_RS18110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SmB9_RS18115	COG0351	phosphomethylpyrimidine kinase
SmB9_RS18115	COG0352	thiamine-phosphate diphosphorylase activity
SmB9_RS18120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SmB9_RS18125	COG1115	amino acid carrier protein
SmB9_RS18130	COG0667	Aldo Keto reductase
SmB9_RS18135	COG0300	oxidoreductase activity
SmB9_RS18145	COG0402	S-adenosylhomocysteine deaminase activity
SmB9_RS18150	COG1228	amidohydrolase
SmB9_RS18155	COG3104	oligopeptide transport
SmB9_RS18170	COG0778	Nitroreductase
SmB9_RS18180	COG1218	3'(2'),5'-bisphosphate nucleotidase
SmB9_RS18210	COG0312	modulator of DNA gyrase
SmB9_RS18225	COG0347	Belongs to the P(II) protein family
SmB9_RS18230	COG0004	ammonium transporteR
SmB9_RS18255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SmB9_RS18270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SmB9_RS18270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SmB9_RS18330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SmB9_RS18335	COG0438	transferase activity, transferring glycosyl groups
SmB9_RS18345	COG1309	transcriptional regulator
SmB9_RS18350	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SmB9_RS18355	COG3724	N-succinylarginine dihydrolase activity
SmB9_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
SmB9_RS18375	COG0028	Belongs to the TPP enzyme family
SmB9_RS18380	COG1024	Enoyl-CoA hydratase
SmB9_RS18385	COG1648	precorrin-2 dehydrogenase activity
SmB9_RS18385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SmB9_RS18395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SmB9_RS18405	COG0175	sulfate reduction
SmB9_RS18410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SmB9_RS18410	COG1648	precorrin-2 dehydrogenase activity
SmB9_RS18420	COG3437	response regulator, receiver
SmB9_RS18455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SmB9_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
SmB9_RS18470	COG0655	NAD(P)H dehydrogenase (quinone) activity
SmB9_RS18500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SmB9_RS18525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SmB9_RS18535	COG1987	bacterial-type flagellum assembly
SmB9_RS18585	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SmB9_RS18595	COG1677	Flagellar hook-basal body complex protein FliE
SmB9_RS18610	COG3135	benzoate transporter
SmB9_RS18630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SmB9_RS18670	COG1558	bacterial-type flagellum-dependent cell motility
SmB9_RS18675	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SmB9_RS18680	COG1749	Flagellar hook protein flgE
SmB9_RS18690	COG4786	Flagellar basal body rod
SmB9_RS18695	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SmB9_RS18700	COG1706	bacterial-type flagellum-dependent cell motility
SmB9_RS18715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SmB9_RS18730	COG2119	membrane
SmB9_RS18740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS18750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SmB9_RS18750	COG0446	pyridine nucleotide-disulphide oxidoreductase
SmB9_RS18770	COG0582	viral genome integration into host DNA
SmB9_RS18785	COG2948	multi-organism process
SmB9_RS18810	COG3451	type IV secretory pathway VirB4
SmB9_RS18825	COG4962	Type ii secretion system protein e
SmB9_RS18860	COG2223	nitrite transmembrane transporter activity
SmB9_RS18865	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SmB9_RS18870	COG1140	nitrate reductase beta subunit
SmB9_RS18875	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SmB9_RS18880	COG2181	nitrate reductase activity
SmB9_RS18890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SmB9_RS18895	COG0521	Mo-molybdopterin cofactor biosynthetic process
SmB9_RS18900	COG0303	'Molybdopterin
SmB9_RS18925	COG3177	Filamentation induced by cAMP protein fic
SmB9_RS18945	COG1475	DNA binding
SmB9_RS18950	COG3344	reverse transcriptase
SmB9_RS18970	COG1522	sequence-specific DNA binding
SmB9_RS18980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmB9_RS18985	COG0251	oxidation-reduction process