locus-tag	class	description
SERIO_RS00040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SERIO_RS00055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SERIO_RS00115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SERIO_RS00215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SERIO_RS00240	COG1349	DNA-binding transcription factor activity
SERIO_RS00290	COG0254	rRNA binding
SERIO_RS00365	COG3845	ABC transporter
SERIO_RS00560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SERIO_RS00580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SERIO_RS00625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SERIO_RS00680	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SERIO_RS00770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SERIO_RS00850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SERIO_RS00860	COG0484	heat shock protein binding
SERIO_RS00880	COG0416	fatty acid biosynthetic process
SERIO_RS01105	COG1192	Involved in chromosome partitioning
SERIO_RS01110	COG1475	DNA binding
SERIO_RS01120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SERIO_RS01250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SERIO_RS01295	COG1098	S1 RNA binding domain
SERIO_RS01305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SERIO_RS01420	COG0089	rRNA binding
SERIO_RS01495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SERIO_RS01530	COG0202	RNA polymerase activity
SERIO_RS01710	COG1217	gtp-binding protein TYPA
SERIO_RS01810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SERIO_RS01845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SERIO_RS02095	COG0543	2 iron, 2 sulfur cluster binding
SERIO_RS02100	COG0167	dihydroorotate dehydrogenase activity
SERIO_RS02105	COG0284	orotidine-5'-phosphate decarboxylase activity
SERIO_RS02130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SERIO_RS02140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SERIO_RS02220	COG0251	oxidation-reduction process
SERIO_RS02270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SERIO_RS02275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SERIO_RS02280	COG1187	pseudouridine synthase activity
SERIO_RS02345	COG1077	Cell shape determining protein MreB Mrl
SERIO_RS02375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SERIO_RS02495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SERIO_RS02525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SERIO_RS02645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SERIO_RS02680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SERIO_RS02690	COG1722	exodeoxyribonuclease VII activity
SERIO_RS02705	COG0006	proline dipeptidase activity
SERIO_RS02840	COG0124	histidyl-tRNA synthetase
SERIO_RS02920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SERIO_RS03195	COG3052	prosthetic group binding
SERIO_RS03245	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SERIO_RS03280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SERIO_RS03310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SERIO_RS03560	COG0322	excinuclease ABC activity
SERIO_RS03580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SERIO_RS03695	COG2131	deaminase
SERIO_RS03705	COG0564	pseudouridine synthase activity
SERIO_RS03725	COG2302	S4 RNA-binding domain
SERIO_RS03870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SERIO_RS03975	COG1136	(ABC) transporter
SERIO_RS03985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SERIO_RS04110	COG0513	Belongs to the DEAD box helicase family
SERIO_RS04395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SERIO_RS04520	COG0194	GDP metabolic process
SERIO_RS04525	COG0742	ribosomal rna small subunit methyltransferase
SERIO_RS04565	COG1214	PFAM Peptidase M22, glycoprotease
SERIO_RS04695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SERIO_RS04700	COG1546	Belongs to the CinA family
SERIO_RS04700	COG1058	Belongs to the CinA family
SERIO_RS04755	COG3599	regulation of cell shape
SERIO_RS04770	COG0776	regulation of translation
SERIO_RS04850	COG0180	Tryptophanyl-tRNA synthetase
SERIO_RS04865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SERIO_RS04895	COG4221	oxidoreductase activity
SERIO_RS04900	COG3142	Participates in the control of copper homeostasis
SERIO_RS04995	COG1461	Dihydroxyacetone kinase
SERIO_RS05060	COG0515	serine threonine protein kinase
SERIO_RS05060	COG2815	serine threonine protein kinase
SERIO_RS05100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SERIO_RS05105	COG1358	cellular component organization or biogenesis
SERIO_RS05185	COG0037	tRNA processing
SERIO_RS05185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SERIO_RS05205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SERIO_RS05220	COG0335	large ribosomal subunit rRNA binding
SERIO_RS05230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SERIO_RS05340	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SERIO_RS05525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SERIO_RS05575	COG0569	domain protein
SERIO_RS05600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SERIO_RS05760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SERIO_RS05825	COG0719	Fe-S assembly protein
SERIO_RS05900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SERIO_RS05955	COG1739	Uncharacterized protein family UPF0029
SERIO_RS06000	COG0222	ribosome binding
SERIO_RS06005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SERIO_RS06140	COG2169	Transcriptional regulator
SERIO_RS06160	COG1077	Cell shape determining protein MreB Mrl
SERIO_RS06195	COG0594	ribonuclease P activity
SERIO_RS06210	COG0517	IMP dehydrogenase activity
SERIO_RS06210	COG0516	GMP reductase activity
SERIO_RS06240	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SERIO_RS06305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system