locus-tag	class	description
SMM_RS00020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMM_RS00055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMM_RS00115	COG1136	(ABC) transporter
SMM_RS00150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMM_RS00165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMM_RS00195	COG0254	rRNA binding
SMM_RS00270	COG3845	ABC transporter
SMM_RS00345	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMM_RS00450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMM_RS00455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMM_RS00495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMM_RS00540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SMM_RS00720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMM_RS00730	COG0484	heat shock protein binding
SMM_RS00745	COG0416	fatty acid biosynthetic process
SMM_RS00855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMM_RS00950	COG1192	Involved in chromosome partitioning
SMM_RS00955	COG1475	DNA binding
SMM_RS01095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMM_RS01160	COG1098	S1 RNA binding domain
SMM_RS01170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMM_RS01295	COG0089	rRNA binding
SMM_RS01370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMM_RS01395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMM_RS01720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMM_RS01810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMM_RS01920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMM_RS01930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMM_RS02030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMM_RS02045	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMM_RS02050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMM_RS02105	COG1077	Cell shape determining protein MreB Mrl
SMM_RS02275	COG0632	four-way junction helicase activity
SMM_RS02295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMM_RS02325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMM_RS02355	COG1737	Transcriptional regulator
SMM_RS02365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMM_RS02405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMM_RS02440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMM_RS02450	COG1722	exodeoxyribonuclease VII activity
SMM_RS02465	COG0006	proline dipeptidase activity
SMM_RS02610	COG0124	histidyl-tRNA synthetase
SMM_RS02620	COG4224	UPF0291 protein
SMM_RS02690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMM_RS02960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SMM_RS02990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMM_RS03255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMM_RS03345	COG2131	deaminase
SMM_RS03355	COG0564	pseudouridine synthase activity
SMM_RS03380	COG1799	cell septum assembly
SMM_RS03505	COG3842	ATPase activity
SMM_RS03535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMM_RS03620	COG1136	(ABC) transporter
SMM_RS03625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMM_RS03705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMM_RS04010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMM_RS04055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMM_RS04125	COG0018	arginyl-trna synthetase
SMM_RS04135	COG0194	GDP metabolic process
SMM_RS04140	COG0742	ribosomal rna small subunit methyltransferase
SMM_RS04165	COG1214	PFAM Peptidase M22, glycoprotease
SMM_RS04245	COG1546	Belongs to the CinA family
SMM_RS04245	COG1058	Belongs to the CinA family
SMM_RS04310	COG3599	regulation of cell shape
SMM_RS04320	COG0776	regulation of translation
SMM_RS04390	COG0180	Tryptophanyl-tRNA synthetase
SMM_RS04540	COG1461	Dihydroxyacetone kinase
SMM_RS04600	COG2815	serine threonine protein kinase
SMM_RS04600	COG0515	serine threonine protein kinase
SMM_RS04630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMM_RS04635	COG1358	cellular component organization or biogenesis
SMM_RS04710	COG0037	tRNA processing
SMM_RS04710	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMM_RS04750	COG0335	large ribosomal subunit rRNA binding
SMM_RS04760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMM_RS04885	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMM_RS04910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMM_RS05140	COG0569	domain protein
SMM_RS05160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMM_RS05255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMM_RS05330	COG0719	Fe-S assembly protein
SMM_RS05405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMM_RS05545	COG0222	ribosome binding
SMM_RS05550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMM_RS05670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMM_RS05690	COG2169	Transcriptional regulator
SMM_RS05710	COG1077	Cell shape determining protein MreB Mrl
SMM_RS05745	COG0594	ribonuclease P activity
SMM_RS05775	COG0517	IMP dehydrogenase activity
SMM_RS05775	COG0516	GMP reductase activity
SMM_RS05805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMM_RS05815	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMM_RS05865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMM_RS05965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMM_RS05965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMM_RS05965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMM_RS05975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMM_RS05975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMM_RS05975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMM_RS06020	COG1131	(ABC) transporter
SMM_RS06140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMM_RS06140	COG1263	PTS System
SMM_RS06150	COG2222	sugar isomerase
SMM_RS06155	COG2222	sugar isomerase
SMM_RS06190	COG1739	Uncharacterized protein family UPF0029