locus-tag class description HU175_RS00010 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HU175_RS00015 ENOG4108SA1 esterase HU175_RS00025 ENOG4105EEQ Na H antiporter HU175_RS00050 ENOG4105BZ1 (ABC) transporter HU175_RS00055 ENOG4107R6T Involved in the transcription termination process (By similarity) HU175_RS00070 ENOG4105VIE preprotein translocase, subunit YajC HU175_RS00080 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HU175_RS00115 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HU175_RS00120 ENOG4107RBB ABC transporter, permease HU175_RS00125 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HU175_RS00130 ENOG4105E08 Glycoside hydrolase, family 9 HU175_RS00145 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HU175_RS00190 ENOG4108CSZ Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HU175_RS00195 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HU175_RS00200 ENOG41068JE domain protein HU175_RS00205 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HU175_RS00210 ENOG4105BZU Histidine kinase HU175_RS00215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU175_RS00230 ENOG4107RBB ABC transporter, permease HU175_RS00235 ENOG4105C19 ABC transporter HU175_RS00300 ENOG4105EGS Mechanosensitive ion channel HU175_RS00310 ENOG4105CPQ Dehydrogenase HU175_RS00315 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HU175_RS00330 ENOG4105CN1 protease HU175_RS00335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HU175_RS00340 ENOG4105FE9 pseudouridine synthase HU175_RS00345 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HU175_RS00350 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HU175_RS00355 ENOG4105CSH Transporter HU175_RS00375 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HU175_RS00380 ENOG4108N5B 2-phosphosulfolactate phosphatase HU175_RS00385 ENOG4105D8V Glucose sorbosone dehydrogenase HU175_RS00400 ENOG4107S2Z UPF0761 membrane protein HU175_RS00415 ENOG4108ZHJ Organic hydroperoxide resistance protein HU175_RS00420 ENOG4105K56 Transcriptional regulator HU175_RS00430 ENOG4105C0R drug resistance transporter emrb qaca subfamily HU175_RS00465 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HU175_RS00470 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HU175_RS00475 ENOG4105C7W Xanthine dehydrogenase HU175_RS00530 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family HU175_RS00590 ENOG4108VYJ response regulator receiver protein HU175_RS00595 ENOG41067HS methyltransferase HU175_RS00610 ENOG4105C3M thioredoxin reductase HU175_RS00650 ENOG4105FA2 dna polymerase iii HU175_RS00655 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HU175_RS00660 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HU175_RS00675 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HU175_RS00680 ENOG41062JF Transcriptional regulator HU175_RS00690 ENOG4105ECP epimerase HU175_RS00695 ENOG410902V Modulates RecA activity (By similarity) HU175_RS00715 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HU175_RS00720 ENOG4107RE3 peptidase, S41 HU175_RS00730 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HU175_RS00790 ENOG4108YZ4 nudix hydrolase HU175_RS00805 ENOG4107S5I aldo keto reductase HU175_RS00830 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HU175_RS00875 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HU175_RS00900 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HU175_RS00910 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HU175_RS00945 ENOG4108VAC response regulator HU175_RS00970 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HU175_RS00985 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HU175_RS01035 ENOG4108NEV two component transcriptional regulator, LytTR family HU175_RS01040 ENOG4108HRK Histidine kinase HU175_RS01055 ENOG41080R2 UPF0102 protein HU175_RS01075 ENOG4105E0A ABC, transporter HU175_RS01080 ENOG4105EHG Permease protein HU175_RS01110 ENOG4105CHR reductase HU175_RS01115 ENOG4105E2A Dehydrogenase HU175_RS01135 ENOG4105D64 Mechanosensitive ion channel HU175_RS01155 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HU175_RS01220 ENOG4105EPD Oligopeptide transporter, Opt family HU175_RS01230 ENOG4105CMG Carbohydrate kinase HU175_RS01245 ENOG41061MV Arylsulfatase HU175_RS01255 ENOG4105C93 Xylose Isomerase HU175_RS01275 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HU175_RS01280 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HU175_RS01305 ENOG4105EUB pirin domain protein HU175_RS01310 ENOG4107ZXU DSBA oxidoreductase HU175_RS01315 ENOG4108RCM Nitroreductase HU175_RS01320 ENOG41076HS cation diffusion facilitator family transporter HU175_RS01340 ENOG4105UYK outer membrane protein a HU175_RS01355 ENOG4105D78 K07001 NTE family protein HU175_RS01360 ENOG4105C8F Beta-lactamase domain protein HU175_RS01380 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HU175_RS01390 ENOG4105CJN penicillin-binding protein HU175_RS01400 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HU175_RS01430 ENOG4105CND Glycosyl transferase, family 2 HU175_RS01475 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS01525 ENOG4105K64 Glycosyl transferase, family 2 HU175_RS01535 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HU175_RS01540 ENOG4107RA4 Glycosyl transferase (Group 1 HU175_RS01550 ENOG4105ER6 polysaccharide biosynthesis protein HU175_RS01555 ENOG4105D3Q Sugar transferase HU175_RS01575 ENOG4105C8Y Acetylornithine aminotransferase HU175_RS01585 ENOG4105KDC 50s ribosomal protein l28 HU175_RS01590 ENOG4105EI2 Pseudouridine synthase HU175_RS01600 ENOG4108ZHJ Organic hydroperoxide resistance protein HU175_RS01620 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HU175_RS01625 ENOG4105DR9 pseudouridine synthase HU175_RS01635 ENOG4105D29 Helix-turn-helix type 11 domain protein HU175_RS01665 ENOG4105C8S subunit m HU175_RS01670 ENOG4105D65 subunit l HU175_RS01695 ENOG4105CPP Dehydrogenase, E1 component HU175_RS01705 ENOG4108ZGC gaf domain protein HU175_RS01740 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HU175_RS01745 ENOG4105DZP Membrane-associated zinc metalloprotease HU175_RS01755 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HU175_RS01765 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HU175_RS01770 ENOG4105C01 Dihydroxy-acid dehydratase HU175_RS01775 ENOG4105C7K acetolactate synthase HU175_RS01785 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HU175_RS01790 ENOG4107QIJ Aconitate hydratase 2 HU175_RS01800 ENOG4105C7B Threonine dehydratase HU175_RS01810 ENOG4105VXP Protein of unknown function DUF86 HU175_RS01815 ENOG4105E7U AraC family transcriptional regulator HU175_RS01820 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HU175_RS01825 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HU175_RS01830 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HU175_RS01835 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HU175_RS01840 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HU175_RS01870 ENOG4105EYH Exonuclease HU175_RS01880 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HU175_RS01890 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HU175_RS01900 ENOG4105D44 asparaginase HU175_RS01920 ENOG4106N3A copper homeostasis protein cutc HU175_RS01925 ENOG4105CIY formyltetrahydrofolate deformylase HU175_RS01935 ENOG4108RIR Molybdenum cofactor biosynthesis protein HU175_RS01940 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HU175_RS01950 ENOG4105C1J atp-dependent rna helicase HU175_RS01965 ENOG4105C30 Nad-dependent epimerase dehydratase HU175_RS02010 ENOG4108SJC Membrane HU175_RS02015 ENOG4108KF3 Electron transport protein SCO1 SenC HU175_RS02025 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HU175_RS02035 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HU175_RS02040 ENOG4107SF2 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HU175_RS02045 ENOG4105BZ9 Cytochrome C oxidase, subunit I HU175_RS02075 ENOG4107SFQ iron-sulfur binding HU175_RS02090 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HU175_RS02100 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HU175_RS02115 ENOG4105CUJ penicillin amidase HU175_RS02120 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HU175_RS02135 ENOG4107RAJ Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HU175_RS02140 ENOG4105F32 YngK protein HU175_RS02150 ENOG4108ZRZ Transcriptional regulator (AsnC family) HU175_RS02160 ENOG4108UGV hypoxanthine phosphoribosyltransferase HU175_RS02165 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS02170 ENOG41083ND 50S ribosomal protein L33 HU175_RS02180 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HU175_RS02205 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HU175_RS02215 ENOG4105VXP Protein of unknown function DUF86 HU175_RS02220 ENOG41074B2 UPF0747 protein HU175_RS02225 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HU175_RS02230 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HU175_RS02285 ENOG4105CJ3 phosphate transporter HU175_RS02290 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HU175_RS02300 ENOG4105KTH gatB Yqey HU175_RS02305 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HU175_RS02320 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HU175_RS02325 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HU175_RS02335 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HU175_RS02345 ENOG4105KCK Peptidoglycan-associated lipoprotein HU175_RS02365 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HU175_RS02380 ENOG4105K64 Glycosyl transferase, family 2 HU175_RS02390 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS02405 ENOG4105IIU Aminopeptidase HU175_RS02415 ENOG4105CI2 imidazolone-5-propionate hydrolase HU175_RS02455 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HU175_RS02460 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HU175_RS02480 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HU175_RS02495 ENOG4105CFH Aspartokinase HU175_RS02500 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HU175_RS02515 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HU175_RS02520 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HU175_RS02525 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HU175_RS02535 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HU175_RS02560 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HU175_RS02570 ENOG4105C0K Gdp-mannose 4,6-dehydratase HU175_RS02580 ENOG4107R0I Cell wall formation (By similarity) HU175_RS02600 ENOG4105DHJ ABC, transporter HU175_RS02605 ENOG4105DN3 alpha-2-macroglobulin domain protein HU175_RS02615 ENOG4105BZU Histidine kinase HU175_RS02620 ENOG4105DVT helicase HU175_RS02645 ENOG4105DU6 RNA polymerase HU175_RS02650 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HU175_RS02680 ENOG4105C0D helicase HU175_RS02685 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HU175_RS02690 ENOG4105D9R oxidoreductase HU175_RS02705 ENOG4105XRQ Xanthine dehydrogenase accessory factor HU175_RS02715 ENOG4107ZNS Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HU175_RS02720 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HU175_RS02740 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family HU175_RS02760 ENOG4105WMR Protein CrcB homolog HU175_RS02765 ENOG4105E5D amino acid HU175_RS02795 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HU175_RS02810 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HU175_RS02820 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HU175_RS02840 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HU175_RS02850 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HU175_RS02875 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HU175_RS02890 ENOG4105BZ1 (ABC) transporter HU175_RS02900 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HU175_RS02910 ENOG4105DF6 Fe-S oxidoreductase HU175_RS02915 ENOG4105DF6 Fe-S oxidoreductase HU175_RS02935 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HU175_RS02940 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HU175_RS02950 ENOG4107VAM peptidase, m28 HU175_RS02955 ENOG4105C8N cysteinyl-tRNA synthetase HU175_RS02970 ENOG4108URH decarboxylase HU175_RS02975 ENOG4105DFU Cell wall formation (By similarity) HU175_RS02985 ENOG4105D82 Glutamate dehydrogenase HU175_RS02990 ENOG4105SCY DNAK suppressor HU175_RS03005 ENOG4108RCS geranylgeranylglyceryl phosphate synthase HU175_RS03020 ENOG4105C1G acyl-Coa dehydrogenase HU175_RS03040 ENOG4105C28 cystathionine HU175_RS03065 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HU175_RS03070 ENOG4105CFH Aspartokinase HU175_RS03085 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HU175_RS03100 ENOG4105C5H ABC transporter HU175_RS03105 ENOG4105CM2 brancheD-chain amino acid aminotransferase HU175_RS03110 ENOG41080AX Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HU175_RS03140 ENOG4105C26 Dehydrogenase HU175_RS03145 ENOG4105D98 threonine synthase HU175_RS03155 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HU175_RS03160 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HU175_RS03175 ENOG4105MJ2 Competence protein HU175_RS03180 ENOG4105E6M Sulphatase-modifying factor protein HU175_RS03185 ENOG4108JA2 transcriptioN-repair coupling factor HU175_RS03210 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HU175_RS03220 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HU175_RS03265 ENOG4105CI3 gtp-binding protein typa HU175_RS03290 ENOG4105EMN RNA polymerase sigma factor HU175_RS03310 ENOG4107T8J thymidine kinase HU175_RS03335 ENOG4105D5U fad dependent oxidoreductase HU175_RS03345 ENOG4107RAN Peptidase, M16 HU175_RS03350 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HU175_RS03360 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HU175_RS03365 ENOG4105CUB amino acid HU175_RS03385 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HU175_RS03390 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HU175_RS03395 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HU175_RS03400 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HU175_RS03405 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HU175_RS03410 ENOG4105WXV 50S ribosomal protein L32 HU175_RS03440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HU175_RS03445 ENOG4105BZU Histidine kinase HU175_RS03450 ENOG4105DZP Membrane-associated zinc metalloprotease HU175_RS03455 ENOG4105CP7 Triose-phosphate isomerase HU175_RS03485 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HU175_RS03500 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HU175_RS03535 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS03555 ENOG4105C0H protease HU175_RS03560 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HU175_RS03565 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HU175_RS03570 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HU175_RS03575 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HU175_RS03610 ENOG4105C2F Histidine kinase HU175_RS03620 ENOG4105C2F Histidine kinase HU175_RS03630 ENOG4108VAC response regulator HU175_RS03640 ENOG4108IYU L-aspartate oxidase HU175_RS03655 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HU175_RS03665 ENOG4105DBI uridine monophosphokinase HU175_RS03670 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HU175_RS03675 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HU175_RS03680 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) HU175_RS03690 ENOG4105C19 ABC transporter HU175_RS03710 ENOG4107V8H Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HU175_RS03715 ENOG4105CSR polyphosphate kinase 2 HU175_RS03720 ENOG4105CSR polyphosphate kinase 2 HU175_RS03740 ENOG4105DC1 bifunctional purine biosynthesis protein purh HU175_RS03750 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HU175_RS03770 ENOG4105BZU Histidine kinase HU175_RS03775 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HU175_RS03795 ENOG4105E0X reductase HU175_RS03800 ENOG4105C9U ATP-dependent DNA helicase RecQ HU175_RS03805 ENOG4108K0D peptidase, M48 HU175_RS03820 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HU175_RS03840 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HU175_RS03845 ENOG4105CRQ synthase (Component I) HU175_RS03855 ENOG4107RI6 Anthranilate phosphoribosyltransferase HU175_RS03860 ENOG4105DK0 Indole-3-glycerol phosphate synthase HU175_RS03865 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HU175_RS03880 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HU175_RS03885 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HU175_RS03890 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HU175_RS03905 ENOG4105C1G acyl-Coa dehydrogenase HU175_RS03910 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HU175_RS03915 ENOG4105CHU acetyl-coa acetyltransferase HU175_RS03925 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS03930 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HU175_RS03950 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS03955 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HU175_RS03960 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS03965 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HU175_RS03980 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HU175_RS03985 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HU175_RS04050 ENOG4105CY0 Metallo-Beta-Lactamase HU175_RS04065 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HU175_RS04085 ENOG4105EPC oxidoreductase HU175_RS04090 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HU175_RS04095 ENOG4108MKI Glycosyl transferase, family 2 HU175_RS04100 ENOG410839U amino acid HU175_RS04110 ENOG4105CQB FAD linked oxidase domain protein HU175_RS04115 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS04150 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HU175_RS04165 ENOG4105E33 succinate dehydrogenase HU175_RS04170 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HU175_RS04175 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HU175_RS04180 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HU175_RS04200 ENOG4108DEF Globin HU175_RS04255 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS04270 ENOG4105C5I Dehydrogenase HU175_RS04295 ENOG4108Z6B deaminase HU175_RS04305 ENOG4105D17 glycoside hydrolase, family 3 domain protein HU175_RS04330 ENOG4105D52 delta-aminolevulinic acid dehydratase HU175_RS04335 ENOG4105CD3 dihydroorotase HU175_RS04400 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HU175_RS04410 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HU175_RS04415 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HU175_RS04450 ENOG4105DKW ABC transporter HU175_RS04460 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HU175_RS04465 ENOG4105BZ9 Cytochrome C oxidase, subunit I HU175_RS04475 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HU175_RS04490 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HU175_RS04505 ENOG4105C0K Gdp-mannose 4,6-dehydratase HU175_RS04525 ENOG4105ER6 polysaccharide biosynthesis protein HU175_RS04535 ENOG4105H63 Glycosyl transferase, family 2 HU175_RS04565 ENOG4108TJN glycosyl transferase group 1 HU175_RS04595 ENOG4105FQP Beta-lactamase HU175_RS04610 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HU175_RS04615 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HU175_RS04640 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS04645 ENOG4105D65 subunit l HU175_RS04650 ENOG4105C8S subunit m HU175_RS04655 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS04685 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HU175_RS04690 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HU175_RS04700 ENOG4107QTF adenylosuccinate lyase HU175_RS04705 ENOG4105II7 pyrroline-5-carboxylate reductase HU175_RS04710 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HU175_RS04730 ENOG4105EMN RNA polymerase sigma factor HU175_RS04735 ENOG4105C2X Arabinose 5-phosphate isomerase HU175_RS04740 ENOG4105C9U ATP-dependent DNA helicase RecQ HU175_RS04745 ENOG4107QNG Phosphoribosylglycinamide synthetase HU175_RS04750 ENOG4105MA4 psp1 domain protein HU175_RS04785 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HU175_RS04795 ENOG4105C9K Endothelin-converting enzyme 1 HU175_RS04840 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HU175_RS04845 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HU175_RS04850 ENOG4107VNI ribosomal protein l10 HU175_RS04855 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HU175_RS04860 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HU175_RS04865 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HU175_RS04900 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HU175_RS04905 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HU175_RS04930 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HU175_RS04935 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HU175_RS04945 ENOG4108V1T peptidylprolyl cis-trans isomerase HU175_RS04950 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HU175_RS04985 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HU175_RS04995 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HU175_RS05020 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HU175_RS05035 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HU175_RS05045 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HU175_RS05060 ENOG4105DY0 carbon monoxide dehydrogenase operon C protein HU175_RS05075 ENOG4105C03 ribonuclease HU175_RS05085 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HU175_RS05095 ENOG4108UUM single-stranded DNA-binding protein HU175_RS05100 ENOG4108JU5 Magnesium and cobalt efflux protein HU175_RS05120 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HU175_RS05140 ENOG4105CXB phosphoribosylaminoimidazole synthetase HU175_RS05160 ENOG4108ZIP spheroidene monooxygenase HU175_RS05165 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HU175_RS05170 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HU175_RS05180 ENOG4105SFS phosphoesterase RecJ domain protein HU175_RS05185 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HU175_RS05190 ENOG4105CSM endonuclease III HU175_RS05200 ENOG4105EMN RNA polymerase sigma factor HU175_RS05210 ENOG4107QN2 dihydrolipoyl dehydrogenase HU175_RS05215 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HU175_RS05230 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HU175_RS05235 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HU175_RS05240 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HU175_RS05245 ENOG4108UJD 30S ribosomal protein S9 HU175_RS05250 ENOG4105CE9 30S ribosomal protein S2 HU175_RS05255 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HU175_RS05280 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HU175_RS05285 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HU175_RS05290 ENOG4105CNI cell division protein FtsW HU175_RS05295 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HU175_RS05300 ENOG4105DFU Cell wall formation (By similarity) HU175_RS05310 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HU175_RS05315 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HU175_RS05370 ENOG4107QNR UPF0135 protein HU175_RS05385 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HU175_RS05415 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HU175_RS05435 ENOG4105KRF dihydroneopterin aldolase HU175_RS05455 ENOG41063JG Transcriptional regulator HU175_RS05460 ENOG4105CMR udp-glucose 4-epimerase HU175_RS05465 ENOG4105C1B dTDP-glucose 4-6-dehydratase HU175_RS05500 ENOG4105CVP deoxyribo-dipyrimidine photolyase HU175_RS05505 ENOG4108V0P LemA family HU175_RS05525 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HU175_RS05530 ENOG4105DEN Luciferase family HU175_RS05545 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS05560 ENOG4105CXK mandelate racemase muconate lactonizing HU175_RS05595 ENOG4105E2D ec 3.2.1.52 HU175_RS05635 ENOG4105CWX Alpha-1,2-mannosidase HU175_RS05700 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HU175_RS05715 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HU175_RS05720 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HU175_RS05725 ENOG4107RWD Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HU175_RS05780 ENOG410903D sensor protein HU175_RS05800 ENOG4105D05 Receptor HU175_RS05805 ENOG4106QJH hemin transport protein HU175_RS05810 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HU175_RS05815 ENOG4105EHG Permease protein HU175_RS05820 ENOG4107R4I Periplasmic binding protein HU175_RS05840 ENOG4107X8C Efflux transporter RND family MFP subunit HU175_RS05895 ENOG4105CPC Aldo Keto reductase HU175_RS05970 ENOG4105C3M thioredoxin reductase HU175_RS06020 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HU175_RS06035 ENOG4105C9M aspartyl-trna synthetase HU175_RS06040 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HU175_RS06080 ENOG4105C3J Cysteine desulfurase HU175_RS06105 ENOG4105DQ4 alcohol dehydrogenase HU175_RS06165 ENOG4105C5H ABC transporter HU175_RS06170 ENOG4105FFC UPF0187 protein HU175_RS06180 ENOG4105C3G gtp-binding protein HU175_RS06190 ENOG4105K6T rare lipoprotein A HU175_RS06200 ENOG4108V06 Glutathione peroxidase HU175_RS06210 ENOG4105CTQ phosphohexokinase HU175_RS06225 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HU175_RS06245 ENOG4105D2T synthase HU175_RS06260 ENOG4105F0R Cytidylyltransferase HU175_RS06265 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HU175_RS06285 ENOG4105C5E polysaccharide biosynthesis protein HU175_RS06305 ENOG4105C3R Methionine synthase HU175_RS06335 ENOG4105CA0 peroxidase HU175_RS06370 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HU175_RS06380 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HU175_RS06405 ENOG4108HRK Histidine kinase HU175_RS06410 ENOG4105DY9 regulatoR HU175_RS06425 ENOG4105CNM Receptor HU175_RS06430 ENOG4105CJ1 ABC, transporter HU175_RS06450 ENOG4105CUB amino acid HU175_RS06460 ENOG4105DA5 (ABC) transporter HU175_RS06475 ENOG4105CIH Imidazole acetol-phosphate transaminase HU175_RS06505 ENOG4105C1V Peptidase, M16 HU175_RS06510 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HU175_RS06520 ENOG4105CEP NADH dehydrogenase HU175_RS06525 ENOG4105CPK Glycosyl transferase (Group 1 HU175_RS06530 ENOG4105YVS arsR family transcriptional regulator HU175_RS06535 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU175_RS06540 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HU175_RS06550 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HU175_RS06570 ENOG4105EPC oxidoreductase HU175_RS06575 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HU175_RS06610 ENOG4105CPC Aldo Keto reductase HU175_RS06615 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HU175_RS06620 ENOG4105CD3 dihydroorotase HU175_RS06675 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HU175_RS06700 ENOG4105DTQ mandelate racemase muconate lactonizing HU175_RS06710 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HU175_RS06740 ENOG4105C6E dna polymerase iii HU175_RS06755 ENOG4107S1Q Phosphatase HU175_RS06790 ENOG4105C9U ATP-dependent DNA helicase RecQ HU175_RS06800 ENOG4105CPC Aldo Keto reductase HU175_RS06805 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HU175_RS06835 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HU175_RS06840 ENOG4108IUZ ABC transporter HU175_RS06850 ENOG41060VI Involved in DNA repair and RecF pathway recombination (By similarity) HU175_RS06855 ENOG4105ERH Fumarylacetoacetate hydrolase HU175_RS06860 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HU175_RS06870 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS06875 ENOG4105CM2 brancheD-chain amino acid aminotransferase HU175_RS06885 ENOG4105D0S secretion protein (HlyD HU175_RS06895 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HU175_RS06910 ENOG4105C0H protease HU175_RS06920 ENOG4105M00 molybdopterin converting factor, subunit 1 HU175_RS06925 ENOG4108ZAF Molybdopterin HU175_RS06935 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HU175_RS06940 ENOG4105CHV Transcription elongation factor NusA HU175_RS06945 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HU175_RS06965 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HU175_RS06970 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HU175_RS06980 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HU175_RS06995 ENOG4105EXC Acyl-transferase HU175_RS07005 ENOG4107TE5 Lipid kinase HU175_RS07015 ENOG4108TJN glycosyl transferase group 1 HU175_RS07020 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HU175_RS07025 ENOG41068WN HU175_RS07030 ENOG4105D1H recombination factor protein RarA HU175_RS07040 ENOG4105CPN adenine deaminase HU175_RS07050 ENOG4105CTX dehydratase HU175_RS07055 ENOG4105CHR reductase HU175_RS07060 ENOG4105ERH Fumarylacetoacetate hydrolase HU175_RS07075 ENOG4105CMG Carbohydrate kinase HU175_RS07095 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HU175_RS07115 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HU175_RS07140 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HU175_RS07145 ENOG4105SKN orotidine 5''-phosphate decarboxylase HU175_RS07200 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HU175_RS07210 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HU175_RS07220 ENOG4105JZI cytochrome P450 HU175_RS07255 ENOG4105EFZ amidohydrolase HU175_RS07265 ENOG4107VMU Membrane HU175_RS07280 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HU175_RS07300 ENOG4105E6M Sulphatase-modifying factor protein HU175_RS07320 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HU175_RS07325 ENOG4108JQC penicillin-binding protein 1A HU175_RS07345 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HU175_RS07355 ENOG4107Z65 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HU175_RS07360 ENOG4105RGC F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HU175_RS07370 ENOG4105K4T epimerase HU175_RS07385 ENOG4105CNI cell division protein FtsW HU175_RS07390 ENOG4108NEV two component transcriptional regulator, LytTR family HU175_RS07430 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HU175_RS07435 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HU175_RS07445 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HU175_RS07480 ENOG4105C2N RNA methyltransferase TrmH family group 3 HU175_RS07495 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HU175_RS07535 ENOG4105C1J atp-dependent rna helicase HU175_RS07570 ENOG4105BZA Phosphoglycerate kinase HU175_RS07580 ENOG4108V1U phospholipid-binding protein HU175_RS07595 ENOG4105EGD dinuclear metal center protein, YbgI family HU175_RS07660 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HU175_RS07670 ENOG4105QVC MOSC domain-containing protein HU175_RS07675 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HU175_RS07690 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HU175_RS07695 ENOG4108JQC penicillin-binding protein 1A HU175_RS07700 ENOG4105E0X reductase HU175_RS07720 ENOG4105C26 Dehydrogenase HU175_RS07740 ENOG4105VRS hydrolase family 18 HU175_RS07770 ENOG4105CYP glycoside hydrolase, family HU175_RS07775 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HU175_RS07780 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU175_RS07785 ENOG4105WH1 Two component transcriptional regulator luxr family HU175_RS07790 ENOG4105CAK Cell division ATP-binding protein ftsE HU175_RS07795 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HU175_RS07800 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HU175_RS07825 ENOG4105ES5 Histidine kinase HU175_RS07840 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HU175_RS07845 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HU175_RS07850 ENOG4105C5X domain protein HU175_RS07860 ENOG4105D74 hydrolase HU175_RS07860 ENOG4105D74 hydrolase HU175_RS07865 ENOG4108KPZ tonB-dependent Receptor HU175_RS07870 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HU175_RS07905 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HU175_RS07945 ENOG4105QE3 oxidoreductase HU175_RS07990 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HU175_RS07995 ENOG4105EXC Acyl-transferase HU175_RS08040 ENOG4106R7G Glycoside hydrolase family 5 HU175_RS08090 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HU175_RS08095 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HU175_RS08105 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HU175_RS08115 ENOG4105E0X reductase HU175_RS08125 ENOG4107QJE Chromosome Partitioning Protein HU175_RS08130 ENOG4105FA0 parb-like partition protein HU175_RS08140 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HU175_RS08145 ENOG4105C3F Signal peptidase i HU175_RS08150 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HU175_RS08175 ENOG41061AI Protein of unknown function (DUF2905) HU175_RS08185 ENOG4105D2N Aldolase HU175_RS08230 ENOG4105DXN mazG family HU175_RS08235 ENOG4105C9X ppx gppa phosphatase HU175_RS08240 ENOG41083X6 30S ribosomal protein S21 HU175_RS08245 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HU175_RS08280 ENOG4108V1T peptidylprolyl cis-trans isomerase HU175_RS08285 ENOG4108Y6J UPF0403 protein HU175_RS08290 ENOG4105VG1 fes assembly suf system protein HU175_RS08310 ENOG4105C9B Cysteine desulfurase HU175_RS08320 ENOG4105C3K feS assembly ATPase SufC HU175_RS08325 ENOG4105CEU Arginine dihydrolase HU175_RS08365 ENOG4105CHR reductase HU175_RS08375 ENOG4105E2D ec 3.2.1.52 HU175_RS08390 ENOG4108TZY GntR Family Transcriptional Regulator HU175_RS08430 ENOG4105DKQ ROK family HU175_RS08450 ENOG4105F5W AtP-binding protein HU175_RS08455 ENOG4105D70 Integrase catalytic subunit HU175_RS08470 ENOG4107QMH DNA methylase HU175_RS08490 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HU175_RS08515 ENOG4107QQG Dehydrogenase HU175_RS08535 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HU175_RS08540 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HU175_RS08560 ENOG4105DMT epimerase dehydratase HU175_RS08565 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HU175_RS08575 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HU175_RS08600 ENOG4105C25 Primosomal protein n' HU175_RS08605 ENOG4105C3M thioredoxin reductase HU175_RS08615 ENOG4105F1N DNA alkylation repair HU175_RS08630 ENOG4105C0D helicase HU175_RS08640 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HU175_RS08660 ENOG4105FQP Beta-lactamase HU175_RS08720 ENOG4105CVR type I restriction-modification system HU175_RS08755 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HU175_RS08775 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HU175_RS08780 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU175_RS08785 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU175_RS08790 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU175_RS08795 ENOG4105DCI Phosphohydrolase HU175_RS08895 ENOG4105CHR reductase HU175_RS08910 ENOG4108I0Y (ABC) transporter HU175_RS08915 ENOG4108UJV acyl-CoA thioesterase i HU175_RS08930 ENOG4105EE5 Membrane protein terC HU175_RS08935 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS08940 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HU175_RS08960 ENOG4105VEQ Cold shock protein HU175_RS08980 ENOG4105BZ1 (ABC) transporter HU175_RS09010 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HU175_RS09020 ENOG4107QI1 Mate efflux family protein HU175_RS09030 ENOG4105CN1 protease HU175_RS09040 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HU175_RS09045 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HU175_RS09060 ENOG4105FAA peptidase M23 HU175_RS09065 ENOG4107QTZ amino acid HU175_RS09070 ENOG4105E2D ec 3.2.1.52 HU175_RS09075 ENOG4107RDY Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HU175_RS09120 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HU175_RS09125 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HU175_RS09130 ENOG4108KPZ tonB-dependent Receptor HU175_RS09145 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HU175_RS09150 ENOG4107QJT sodium dicarboxylate symporter HU175_RS09160 ENOG4107RNH Outer membrane receptor FepA HU175_RS09210 ENOG4105CQB FAD linked oxidase domain protein HU175_RS09240 ENOG4107RBB ABC transporter, permease HU175_RS09245 ENOG4105CHR reductase HU175_RS09250 ENOG4105C5E polysaccharide biosynthesis protein HU175_RS09255 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HU175_RS09285 ENOG4105CI2 imidazolone-5-propionate hydrolase HU175_RS09315 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS09320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS09325 ENOG4107RBB ABC transporter, permease HU175_RS09330 ENOG4108VAC response regulator HU175_RS09345 ENOG4108HRK Histidine kinase HU175_RS09350 ENOG4107RBB ABC transporter, permease HU175_RS09360 ENOG4107RBB ABC transporter, permease HU175_RS09370 ENOG4105EHZ conserved protein UCP016719 HU175_RS09375 ENOG4107RBB ABC transporter, permease HU175_RS09380 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HU175_RS09385 ENOG4107RBB ABC transporter, permease HU175_RS09390 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS09395 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS09400 ENOG4107RBB ABC transporter, permease HU175_RS09405 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS09410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS09435 ENOG4107RBB ABC transporter, permease HU175_RS09465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU175_RS09485 ENOG4105BZU Histidine kinase HU175_RS09490 ENOG4105BZU Histidine kinase HU175_RS09525 ENOG4105PGM cation diffusion facilitator family transporter HU175_RS09530 ENOG4105NRA 50s ribosomal protein l31 type b HU175_RS09535 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HU175_RS09560 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HU175_RS09570 ENOG4105CEY Amp-dependent synthetase and ligase HU175_RS09580 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HU175_RS09585 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HU175_RS09595 ENOG4105DCF alanine dehydrogenase HU175_RS09600 ENOG4105K8N protein family UPF0079, ATPase HU175_RS09610 ENOG4105CPF Cell wall formation (By similarity) HU175_RS09615 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HU175_RS09635 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HU175_RS09640 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HU175_RS09645 ENOG41080B9 Binds together with S18 to 16S ribosomal RNA (By similarity) HU175_RS09655 ENOG4105DFA alanine racemase domain protein HU175_RS09670 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HU175_RS09695 ENOG4105CZV ABC transporter HU175_RS09705 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HU175_RS09715 ENOG41077A9 carbonic anhydrase HU175_RS09720 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HU175_RS09725 ENOG4105GR3 Histidine kinase HU175_RS09740 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HU175_RS09745 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HU175_RS09765 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HU175_RS09780 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HU175_RS09785 ENOG4105C31 Tryptophanyl-tRNA synthetase HU175_RS09790 ENOG4105C6K Malic enzyme HU175_RS09795 ENOG4105KA0 thioesterase Superfamily protein HU175_RS09800 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HU175_RS09805 ENOG4108HRK Histidine kinase HU175_RS09810 ENOG4108NEV two component transcriptional regulator, LytTR family HU175_RS09825 ENOG4105DCF alanine dehydrogenase HU175_RS09830 ENOG4105EW9 transcriptional regulator AsnC family HU175_RS09850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HU175_RS09875 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HU175_RS09895 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HU175_RS09920 ENOG4105CG3 alpha amylase, catalytic region HU175_RS09925 ENOG4108IUK alpha amylase, catalytic HU175_RS09930 ENOG4105BZU Histidine kinase HU175_RS09940 ENOG41074H6 response regulator HU175_RS09945 ENOG4107URF beta-phospho-glucomutase HU175_RS09970 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HU175_RS09975 ENOG410823G oxidoreductase HU175_RS09995 ENOG4108YBP pseudouridine synthase HU175_RS10000 ENOG4108NEV two component transcriptional regulator, LytTR family HU175_RS10040 ENOG4108MGY Histidine kinase HU175_RS10045 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HU175_RS10055 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HU175_RS10075 ENOG4105CWX Alpha-1,2-mannosidase HU175_RS10080 ENOG4105C0D helicase HU175_RS10085 ENOG4107QMH DNA methylase HU175_RS10090 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HU175_RS10135 ENOG4105C7W Xanthine dehydrogenase HU175_RS10150 ENOG4108W6C Dehydrogenase HU175_RS10160 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HU175_RS10175 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU175_RS10180 ENOG4108FN7 Aldo keto reductase HU175_RS10190 ENOG4105BZU Histidine kinase HU175_RS10200 ENOG4107QZF nitrite reductase NADPH large subunit HU175_RS10205 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HU175_RS10215 ENOG4107RNU major facilitator superfamily MFS_1 HU175_RS10230 ENOG4105CGZ zinc metallopeptidase HU175_RS10270 ENOG4105CPC Aldo Keto reductase HU175_RS10275 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HU175_RS10280 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HU175_RS10290 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HU175_RS10300 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HU175_RS10315 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HU175_RS10320 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HU175_RS10330 ENOG4105DY9 regulatoR HU175_RS10340 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HU175_RS10365 ENOG4105FTV AraC Family Transcriptional Regulator HU175_RS10370 ENOG4107TTA Xylose isomerase domain protein TIM barrel HU175_RS10380 ENOG41090JD Blue (Type 1) copper domain protein HU175_RS10405 ENOG4105CG3 alpha amylase, catalytic region HU175_RS10410 ENOG4108QG2 Membrane HU175_RS10425 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HU175_RS10445 ENOG4105VIZ double-strand break repair protein HU175_RS10465 ENOG4105EAA nucleoside HU175_RS10480 ENOG4105CGK Exodeoxyribonuclease III HU175_RS10490 ENOG4105W5Q DNA repair protein (RadC HU175_RS10495 ENOG4105RA3 Binds directly to 16S ribosomal RNA (By similarity) HU175_RS10525 ENOG4105DR4 Methyltransferase HU175_RS10535 ENOG4105K63 Thioredoxin HU175_RS10545 ENOG4105D8X mechanosensitive ion channel HU175_RS10550 ENOG4107QI6 Cysteine desulfurase HU175_RS10570 ENOG4105E39 Enoyl-CoA hydratase HU175_RS10575 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HU175_RS10585 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HU175_RS10590 ENOG4107RJ1 sodium solute HU175_RS10600 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HU175_RS10610 ENOG4105C1J atp-dependent rna helicase HU175_RS10615 ENOG4105EMU Dehydrogenase HU175_RS10645 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HU175_RS10650 ENOG4105C5S asparaginyl-tRNA synthetase HU175_RS10665 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HU175_RS10670 ENOG4105D74 hydrolase HU175_RS10685 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HU175_RS10690 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HU175_RS10700 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HU175_RS10720 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C HU175_RS10730 ENOG4105CEV competence damage-inducible protein HU175_RS10745 ENOG4105KUZ arsenate reductase HU175_RS10775 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HU175_RS10835 ENOG4105CHR reductase HU175_RS10845 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HU175_RS10855 ENOG4108NEV two component transcriptional regulator, LytTR family HU175_RS10875 ENOG4108IUX (ABC) transporter HU175_RS10890 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HU175_RS10925 ENOG4108Z9Z response to DNA damage stimulus HU175_RS10940 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HU175_RS10945 ENOG4105DGU Histone deacetylase HU175_RS10975 ENOG4105DR9 pseudouridine synthase HU175_RS10995 ENOG4105F5H Glycosyl Hydrolase Family 88 HU175_RS11060 ENOG4105DZG Dehydrogenase HU175_RS11075 ENOG4105E6M Sulphatase-modifying factor protein HU175_RS11080 ENOG4105CBG Sulfatase HU175_RS11095 ENOG4105H4N Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HU175_RS11100 ENOG4105D60 lipoprotein releasing system transmembrane protein HU175_RS11110 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HU175_RS11130 ENOG4105EDR glucose galactose transporter HU175_RS11135 ENOG4105EPC oxidoreductase HU175_RS11150 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HU175_RS11155 ENOG4105EUJ GTP cyclohydrolase i HU175_RS11160 ENOG4108MR6 WD40-like Beta Propeller Repeat HU175_RS11165 ENOG4105CHR reductase HU175_RS11200 ENOG4105EMN RNA polymerase sigma factor HU175_RS11210 ENOG4105BZS acriflavin resistance protein HU175_RS11215 ENOG410624X efflux transporter, rnd family, mfp subunit HU175_RS11240 ENOG4105DZ0 fad dependent oxidoreductase HU175_RS11245 ENOG4108HKT sucrose-6-phosphate hydrolase HU175_RS11295 ENOG4105C1G acyl-Coa dehydrogenase HU175_RS11345 ENOG4105CCT upf0313 protein HU175_RS11370 ENOG4105IIU Aminopeptidase HU175_RS11380 ENOG4105CXT aspartate transcarbamylase HU175_RS11390 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HU175_RS11410 ENOG4105D05 Receptor HU175_RS11440 ENOG4105NQG DoxX HU175_RS11450 ENOG4105CG3 alpha amylase, catalytic region HU175_RS11455 ENOG4105CG3 alpha amylase, catalytic region HU175_RS11470 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS11495 ENOG4108Z03 MAF-like protein HU175_RS11510 ENOG4108YYC ycei family HU175_RS11520 ENOG4105FYV Amp nucleosidase HU175_RS11530 ENOG4107Y70 Heat shock protein HU175_RS11535 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HU175_RS11540 ENOG4105CKW Inner membrane protein yedI HU175_RS11560 ENOG4105CH7 arginosuccinase HU175_RS11585 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HU175_RS11590 ENOG4105BZ9 Cytochrome C oxidase, subunit I HU175_RS11610 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HU175_RS11615 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HU175_RS11620 ENOG4107QZW Altronate oxidoreductase HU175_RS11635 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HU175_RS11645 ENOG4105D2H Uronic isomerase HU175_RS11650 ENOG4105D74 hydrolase HU175_RS11665 ENOG4105C9K Endothelin-converting enzyme 1 HU175_RS11680 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HU175_RS11685 ENOG4108JQ1 Dehydrogenase HU175_RS11690 ENOG4105VXP Protein of unknown function DUF86 HU175_RS11700 ENOG4105DNZ Alpha Beta Hydrolase HU175_RS11720 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HU175_RS11725 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HU175_RS11730 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HU175_RS11745 ENOG4105BZU Histidine kinase HU175_RS11750 ENOG4105BZU Histidine kinase HU175_RS11755 ENOG4105BZU Histidine kinase HU175_RS11760 ENOG4105BZU Histidine kinase HU175_RS11765 ENOG4107Z5C methylesterase HU175_RS11785 ENOG4105ETE Transcriptional regulator (LacI family HU175_RS11790 ENOG4105CE4 GlcNAc 6-P deacetylase HU175_RS11795 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HU175_RS11820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HU175_RS11825 ENOG4107Y7Q pfkb domain protein HU175_RS11830 ENOG4105CT4 transporter HU175_RS11865 ENOG4105EMN RNA polymerase sigma factor HU175_RS11870 ENOG4105CM2 brancheD-chain amino acid aminotransferase HU175_RS11875 ENOG4108WBT adenosyltransferase HU175_RS11885 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HU175_RS11890 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HU175_RS11920 ENOG4105C5X domain protein HU175_RS11940 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HU175_RS11975 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HU175_RS11980 ENOG4105JAB phenazine biosynthesis protein, phzf family HU175_RS11995 ENOG4105CSA Coproporphyrinogen iii oxidase HU175_RS12000 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HU175_RS12010 ENOG4108UKZ OsmC family HU175_RS12015 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HU175_RS12040 ENOG4105DCG PHP domain protein HU175_RS12070 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HU175_RS12085 ENOG4107Y2X deaminase HU175_RS12095 ENOG4105EXC Acyl-transferase HU175_RS12135 ENOG4108REF Sporulation integral membrane protein ytvi HU175_RS12140 ENOG4105EJQ L-serine dehydratase HU175_RS12150 ENOG4107QKZ Ompa motb domain protein HU175_RS12165 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HU175_RS12170 ENOG4108VVK transcriptional Regulator, AsnC HU175_RS12175 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HU175_RS12215 ENOG4105CY0 Metallo-Beta-Lactamase HU175_RS12220 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HU175_RS12260 ENOG4105DVT helicase HU175_RS12270 ENOG4108YZG isomerase HU175_RS12275 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HU175_RS12280 ENOG4105M5J Cupin 2, conserved barrel domain protein HU175_RS12285 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) HU175_RS12310 ENOG4105CNM Receptor HU175_RS12325 ENOG4105C1J atp-dependent rna helicase HU175_RS12330 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HU175_RS12335 ENOG4105DPW Major facilitator superfamily MFS_1 HU175_RS12355 ENOG4105C72 UPF0176 protein HU175_RS12370 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HU175_RS12400 ENOG4108I0Z Aconitate hydratase HU175_RS12410 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HU175_RS12415 ENOG4105D3Q Sugar transferase HU175_RS12475 ENOG4105PSV Polysaccharide Biosynthesis Protein HU175_RS12480 ENOG4108STX response regulator HU175_RS12485 ENOG4105GR3 Histidine kinase HU175_RS12500 ENOG4107QZ7 Cellulose synthase catalytic subunit HU175_RS12520 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HU175_RS12525 ENOG4105M5P UPF0310 protein HU175_RS12570 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS12585 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU175_RS12590 ENOG4105DFH Transport of potassium into the cell (By similarity) HU175_RS12600 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HU175_RS12620 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HU175_RS12650 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU175_RS12715 ENOG4105F5W AtP-binding protein HU175_RS12720 ENOG4105D70 Integrase catalytic subunit HU175_RS12755 ENOG4107QIK phosphoribosylformylglycinamidine synthase HU175_RS12760 ENOG4105ECY inositol monophosphatase HU175_RS12785 ENOG4105D7N magnesium and cobalt transport protein CorA HU175_RS12790 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HU175_RS12795 ENOG4105F5H Glycosyl Hydrolase Family 88 HU175_RS12815 ENOG4107SUZ Sodium/hydrogen exchanger family HU175_RS12830 ENOG4105DKB L-sorbosone dehydrogenase HU175_RS12855 ENOG4105C37 (CBS) domain HU175_RS12865 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HU175_RS12870 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HU175_RS12885 ENOG4105BZU Histidine kinase HU175_RS12900 ENOG4105Q95 Cupin 2, conserved barrel domain protein HU175_RS12930 ENOG4105C6Z Gluconate HU175_RS12940 ENOG4105E2D ec 3.2.1.52 HU175_RS12945 ENOG4105E98 transcriptional regulator DeoR family HU175_RS12970 ENOG4105C9K Endothelin-converting enzyme 1 HU175_RS12980 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HU175_RS13010 ENOG4105CHR reductase HU175_RS13095 ENOG4107R55 ethanolamine transporter HU175_RS13105 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HU175_RS13115 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HU175_RS13125 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HU175_RS13160 ENOG4107RTD sua5 ycio yrdc ywlc family protein HU175_RS13165 ENOG4107QJZ Glycosyl transferase, family 2 HU175_RS13170 ENOG4107U9T Pfam:Ribonuclease_BN HU175_RS13180 ENOG4105HHA aminodeoxychorismate lyase HU175_RS13205 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HU175_RS13210 ENOG4105E2D ec 3.2.1.52 HU175_RS13230 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HU175_RS13270 ENOG4107YWA deoxycytidylate deaminase HU175_RS13300 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HU175_RS13320 ENOG4105FQP Beta-lactamase HU175_RS13360 ENOG4106R7G Glycoside hydrolase family 5 HU175_RS13380 ENOG41062D9 Histidine kinase HU175_RS13385 ENOG4108STX response regulator HU175_RS13405 ENOG4105VCH membrane HU175_RS13415 ENOG410874W AraC family transcriptional regulator HU175_RS13425 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HU175_RS13445 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HU175_RS13480 ENOG4105R8A Heat shock protein HU175_RS13490 ENOG4107V8H Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HU175_RS13505 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HU175_RS13570 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HU175_RS13695 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HU175_RS13705 ENOG4105BZU Histidine kinase HU175_RS13710 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HU175_RS13715 ENOG4105ESV Glycosyl transferase, family 4 HU175_RS13725 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HU175_RS13730 ENOG4106WTF Glycosyl transferase, family 2 HU175_RS13740 ENOG4107RA4 Glycosyl transferase (Group 1 HU175_RS13745 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HU175_RS13760 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HU175_RS13790 ENOG4105EXC Acyl-transferase HU175_RS13795 ENOG4105JNK Glycosyl transferase (Group 1 HU175_RS13820 ENOG4105EY8 ABC transporter HU175_RS13840 ENOG4105DNX Dna topoisomerase iv (Subunit b) HU175_RS13860 ENOG4107QUV Domain protein HU175_RS13870 ENOG4105C98 muts2 protein HU175_RS13885 ENOG4105WEF catalase HU175_RS13905 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) HU175_RS13925 ENOG4105K5M 30s ribosomal protein S16 HU175_RS13930 ENOG4107YAY An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HU175_RS13935 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HU175_RS13985 ENOG4105EPC oxidoreductase HU175_RS13990 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS14000 ENOG4108Z9K Osmotically inducible protein HU175_RS14020 ENOG4108JYZ YitT family HU175_RS14050 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HU175_RS14070 ENOG4105C28 cystathionine HU175_RS14075 ENOG410635A Membrane HU175_RS14085 ENOG4105C8T Leucyl-tRNA synthetase HU175_RS14090 ENOG4105VEQ Cold shock protein HU175_RS14140 ENOG4108Z40 Transcriptional regulator HU175_RS14150 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HU175_RS14160 ENOG4105UYK outer membrane protein a HU175_RS14175 ENOG4105CSM endonuclease III HU175_RS14180 ENOG4105T16 Transcriptional regulator (AraC family) HU175_RS14185 ENOG4105CPC Aldo Keto reductase HU175_RS14190 ENOG4105CPC Aldo Keto reductase HU175_RS14195 ENOG4106UW1 Major Facilitator superfamily HU175_RS14210 ENOG4105DQ4 alcohol dehydrogenase HU175_RS14215 ENOG4105KVH Transcriptional regulator HU175_RS14220 ENOG4105ECR NmrA family HU175_RS14225 ENOG4108MYR Secreted protein HU175_RS14230 ENOG4105E0X reductase HU175_RS14240 ENOG4105C7W Xanthine dehydrogenase HU175_RS14250 ENOG4105C7W Xanthine dehydrogenase HU175_RS14255 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HU175_RS14260 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HU175_RS14265 ENOG4108UW5 maltose o-acetyltransferase HU175_RS14280 ENOG4107SET aldo keto reductase HU175_RS14290 ENOG4105CPC Aldo Keto reductase HU175_RS14315 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HU175_RS14355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU175_RS14370 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HU175_RS14400 ENOG4108IPT Naphthoate synthase HU175_RS14410 ENOG4107R6D beta-lactam binding protein AmpH HU175_RS14460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HU175_RS14470 ENOG4105C1J atp-dependent rna helicase HU175_RS14480 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis HU175_RS14485 ENOG4105C1J atp-dependent rna helicase HU175_RS14490 ENOG4105CD3 dihydroorotase HU175_RS14555 ENOG4108ETT Dehydrogenase HU175_RS14585 ENOG4105EKQ RNA-directed DNA polymerase HU175_RS14600 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HU175_RS14605 ENOG4105CFG Acts as a chaperone (By similarity) HU175_RS14630 ENOG4105DEU major facilitator superfamily HU175_RS14645 ENOG4105C7Z Conserved Protein HU175_RS14650 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HU175_RS14675 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HU175_RS14700 ENOG4105BZU Histidine kinase HU175_RS14705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HU175_RS14735 ENOG4105BZU Histidine kinase HU175_RS14740 ENOG4107Z5C methylesterase HU175_RS14755 ENOG4105CDV Ompa motb domain protein HU175_RS14795 ENOG4105D64 Mechanosensitive ion channel HU175_RS14810 ENOG4105CMR udp-glucose 4-epimerase HU175_RS14815 ENOG4105BZU Histidine kinase HU175_RS14825 ENOG4105CIR epoxide hydrolase HU175_RS14830 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HU175_RS14855 ENOG4105C28 cystathionine HU175_RS14870 ENOG4105E7U AraC family transcriptional regulator HU175_RS14875 ENOG4108JUA Transcriptional regulator HU175_RS14895 ENOG4105RAK Histidine kinase HU175_RS14920 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HU175_RS14925 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HU175_RS14930 ENOG4108YIQ Alpha beta hydrolase HU175_RS14945 ENOG41063TF transcriptional regulator (AraC HU175_RS14955 ENOG4108URH decarboxylase HU175_RS15015 ENOG4105NQG DoxX HU175_RS15030 ENOG4105C26 Dehydrogenase HU175_RS15070 ENOG4105EEI dihydropteroate synthase HU175_RS15100 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HU175_RS15120 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HU175_RS15145 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HU175_RS15170 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HU175_RS15175 ENOG4105DTQ mandelate racemase muconate lactonizing HU175_RS15180 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HU175_RS15220 ENOG4107SFI Major Facilitator superfamily HU175_RS15250 ENOG410870W N-acetyltransferase HU175_RS15305 ENOG4107QYX exodeoxyribonuclease v alpha HU175_RS15350 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HU175_RS15355 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HU175_RS15360 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HU175_RS15405 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HU175_RS15410 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HU175_RS15420 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HU175_RS15430 ENOG4105K64 Glycosyl transferase, family 2 HU175_RS15445 ENOG4105CUT histidyl-tRNA synthetase HU175_RS15480 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HU175_RS15485 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HU175_RS15515 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HU175_RS15530 ENOG4107UGT Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HU175_RS15535 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HU175_RS15540 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HU175_RS15560 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HU175_RS15600 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HU175_RS15605 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HU175_RS15610 ENOG41082BM Transcriptional regulator, arsr family HU175_RS15675 ENOG4105CP2 von willebrand factor, type a HU175_RS15690 ENOG4105D8V Glucose sorbosone dehydrogenase HU175_RS15700 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HU175_RS15705 ENOG4105VJV 50s ribosomal protein L35 HU175_RS15710 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HU175_RS15715 ENOG4105C22 threonyL-tRNA synthetase HU175_RS15725 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HU175_RS15745 ENOG4108UB4 uncharacterized protein ygjQ HU175_RS15750 ENOG4105DF5 DNA topoisomerase IV, subunit A HU175_RS15765 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HU175_RS15770 ENOG4105KZX Pterin carbinolamine dehydratase HU175_RS15775 ENOG4105BZU Histidine kinase HU175_RS15790 ENOG4105BZU Histidine kinase HU175_RS15805 ENOG4105CHM Aminotransferase HU175_RS15825 ENOG4105CXK mandelate racemase muconate lactonizing HU175_RS15830 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS15840 ENOG4105CXK mandelate racemase muconate lactonizing HU175_RS15865 ENOG4105DZG Dehydrogenase HU175_RS15870 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HU175_RS15875 ENOG4108UHU Aldolase HU175_RS15880 ENOG4105DPW Major facilitator superfamily MFS_1 HU175_RS15925 ENOG4105D7W serine acetyltransferase HU175_RS15940 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HU175_RS15950 ENOG4105DKQ ROK family HU175_RS15955 ENOG4108RAV Conserved protein HU175_RS15975 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HU175_RS15985 ENOG4105CPQ Dehydrogenase HU175_RS15990 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HU175_RS15995 ENOG4107XPB Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HU175_RS16000 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HU175_RS16010 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HU175_RS16070 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS16085 ENOG4105DGW oligopeptidase A HU175_RS16090 ENOG4105EQK -acetyltransferase HU175_RS16095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HU175_RS16100 ENOG4105BZU Histidine kinase HU175_RS16125 ENOG4105BZU Histidine kinase HU175_RS16190 ENOG4105D70 Integrase catalytic subunit HU175_RS16195 ENOG4105F5W AtP-binding protein HU175_RS16200 ENOG4105EKQ RNA-directed DNA polymerase HU175_RS16235 ENOG4105C7W Xanthine dehydrogenase HU175_RS16240 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HU175_RS16245 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HU175_RS16255 ENOG4105EUB pirin domain protein HU175_RS16270 ENOG4105CA0 peroxidase HU175_RS16290 ENOG4105G6Z alkaline phosphatase HU175_RS16290 ENOG4105G6Z alkaline phosphatase HU175_RS16310 ENOG4107QJT sodium dicarboxylate symporter HU175_RS16325 ENOG4105VDW Csbd family HU175_RS16340 ENOG4105FDR Membrane HU175_RS16345 ENOG4105CHR reductase HU175_RS16350 ENOG4105C01 Dihydroxy-acid dehydratase HU175_RS16360 ENOG4108Z7R Chaperone CsaA HU175_RS16370 ENOG4105E4C Lytic transglycosylase catalytic HU175_RS16375 ENOG4105CY3 ABC transporter, permease HU175_RS16380 ENOG4105DHJ ABC, transporter HU175_RS16430 ENOG4105CHR reductase HU175_RS16435 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HU175_RS16490 ENOG4108YZY peptidylprolyl cis-trans isomerase HU175_RS16495 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HU175_RS16520 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HU175_RS16530 ENOG4105ETE Transcriptional regulator (LacI family HU175_RS16540 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) HU175_RS16545 ENOG4105CHR reductase HU175_RS16550 ENOG4105DT9 hydrolase family 43 HU175_RS16555 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HU175_RS16585 ENOG4105EK5 Glycoside hydrolase family 8 HU175_RS16590 ENOG4105DYC esterase HU175_RS16625 ENOG4105CGS Alpha-glucosidase HU175_RS16665 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HU175_RS16675 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HU175_RS16680 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HU175_RS16705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HU175_RS16710 ENOG4105EB3 Histidine kinase HU175_RS16745 ENOG4105EMU Dehydrogenase HU175_RS16750 ENOG4105ECQ AraC Family Transcriptional Regulator HU175_RS16795 ENOG4105CDU Replicative dna helicase HU175_RS16825 ENOG4105C3M thioredoxin reductase HU175_RS16830 ENOG4105DR5 peptidase HU175_RS16845 ENOG4105C10 Electron transfer flavoprotein HU175_RS16850 ENOG4105BZJ Electron transfer flavoprotein HU175_RS16865 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HU175_RS16870 ENOG4108RMU ferritin dps family protein HU175_RS16935 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HU175_RS16940 ENOG4105CNT hydrolase family 2 HU175_RS16970 ENOG4105ETE Transcriptional regulator (LacI family HU175_RS17015 ENOG4105C6Z Gluconate HU175_RS17055 ENOG4105K46 50S ribosomal protein l27 HU175_RS17060 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HU175_RS17070 ENOG41061P3 phosphosulfolactate synthase HU175_RS17075 ENOG4105DQR SNARE associated Golgi HU175_RS17080 ENOG4105E2X shikimate dehydrogenase HU175_RS17090 ENOG4108UQ1 hydrolase, family 25 HU175_RS17100 ENOG4105D3R alkyl hydroperoxide reductase HU175_RS17105 ENOG4105WH1 Two component transcriptional regulator luxr family HU175_RS17110 ENOG4105ENE Histidine kinase HU175_RS17125 ENOG4105VEQ Cold shock protein HU175_RS17135 ENOG4108QBX (LipO)protein HU175_RS17190 ENOG4105CQC Prephenate dehydratase HU175_RS17210 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HU175_RS17215 ENOG4108UVJ appr-1-p processing domain protein HU175_RS17255 ENOG4108JPW Aminotransferase HU175_RS17270 ENOG4105CX6 glutaminyL-tRNA synthetase HU175_RS17280 ENOG4108Z0Z intracellular protease Pfpi family HU175_RS17285 ENOG4105SYT Methylenetetrahydrofolate reductase HU175_RS17295 ENOG4107QKA exodeoxyribonuclease V beta HU175_RS17305 ENOG4105CIH Imidazole acetol-phosphate transaminase HU175_RS17310 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HU175_RS17325 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HU175_RS17330 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HU175_RS17345 ENOG4108NEV two component transcriptional regulator, LytTR family HU175_RS17350 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HU175_RS17355 ENOG4106VK6 Flagellar motor protein HU175_RS17360 ENOG4105C59 p-type ATPase HU175_RS17420 ENOG4105M3Z response regulator HU175_RS17450 ENOG4105C5Z peptidase HU175_RS17470 ENOG4105EBR Carboxylesterase HU175_RS17565 ENOG4105D70 Integrase catalytic subunit HU175_RS17575 ENOG4105F5W AtP-binding protein HU175_RS17580 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HU175_RS17605 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HU175_RS17610 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 HU175_RS17615 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HU175_RS17650 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HU175_RS17660 ENOG4108KF3 Electron transport protein SCO1 SenC HU175_RS17680 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HU175_RS17685 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HU175_RS17715 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HU175_RS17720 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HU175_RS17730 ENOG4107X35 defense response to bacterium HU175_RS17745 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HU175_RS17780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HU175_RS17785 ENOG4105GR3 Histidine kinase HU175_RS17790 ENOG4105EGS Mechanosensitive ion channel HU175_RS17805 ENOG4105DJY efflux transporter, rnd family, mfp subunit HU175_RS17850 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HU175_RS17860 ENOG4105F8J Adenylate Guanylate cyclase HU175_RS17880 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the HU175_RS17890 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HU175_RS17910 ENOG4105CBX hi0933 family HU175_RS17915 ENOG4105DTN riboflavin biosynthesis protein ribF HU175_RS17920 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HU175_RS17925 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HU175_RS17935 ENOG4107RJ9 Cell division protein FtsX HU175_RS17945 ENOG4108HKT sucrose-6-phosphate hydrolase HU175_RS17970 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HU175_RS17975 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HU175_RS17980 ENOG4105CS1 NAD(P)H quinone oxidoreductase HU175_RS17995 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS18010 ENOG4105CKB glycosidase HU175_RS18035 ENOG4107TT5 NLP P60 protein HU175_RS18040 ENOG4107T6X nag kinase HU175_RS18050 ENOG4105C8Y Acetylornithine aminotransferase HU175_RS18075 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HU175_RS18090 ENOG4105CN9 Peptidase m42 family protein HU175_RS18110 ENOG4108ZX5 transcriptional regulator HU175_RS18130 ENOG4105EV8 ectoine hydroxylase HU175_RS18140 ENOG4105CE4 GlcNAc 6-P deacetylase HU175_RS18145 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU175_RS18150 ENOG4105WAB arsR family transcriptional regulator HU175_RS18160 ENOG4107RPQ ABC transporter HU175_RS18180 ENOG4105CND Glycosyl transferase, family 2 HU175_RS18190 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS18195 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS18205 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HU175_RS18235 ENOG4107ZSV Receptor HU175_RS18245 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HU175_RS18265 ENOG4105DG4 malate L-lactate dehydrogenase HU175_RS18290 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HU175_RS18295 ENOG4105C7N Xanthine uracil vitamin C permease HU175_RS18300 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HU175_RS18330 ENOG4105DWV Homoserine O-trans-acetylase HU175_RS18360 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS18385 ENOG4105C0R drug resistance transporter emrb qaca subfamily HU175_RS18390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HU175_RS18475 ENOG4105CSH Transporter HU175_RS18505 ENOG4107QKV phosphomannomutase HU175_RS18515 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HU175_RS18525 ENOG4105EHZ conserved protein UCP016719 HU175_RS18530 ENOG4107R34 abc transporter permease protein HU175_RS18540 ENOG4105DHU Bile acid HU175_RS18550 ENOG4105CUB amino acid HU175_RS18565 ENOG4108NEV two component transcriptional regulator, LytTR family HU175_RS18575 ENOG4105DWT malate dehydrogenase (quinone) HU175_RS18580 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HU175_RS18600 ENOG4106H3A restriction HU175_RS18610 ENOG4105CHR reductase HU175_RS18620 ENOG4105C9Q fumarate hydratase class II HU175_RS18660 ENOG4105D3R alkyl hydroperoxide reductase HU175_RS18675 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HU175_RS18685 ENOG4105K64 Glycosyl transferase, family 2 HU175_RS18690 ENOG4108ZJ4 polysaccharide deacetylase HU175_RS18700 ENOG4105F8V Hydrolase, tatD family HU175_RS18705 ENOG4105HDK L-asparaginase HU175_RS18790 ENOG4105CAY ferredoxin--nadp reductase HU175_RS18800 ENOG4105K8R UPF0145 protein HU175_RS18815 ENOG4108JQ1 Dehydrogenase HU175_RS18820 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HU175_RS18825 ENOG4105DSJ YicC domain protein HU175_RS18835 ENOG4108VX5 3-methyladenine DNA glycosylase HU175_RS18840 ENOG4105EYM Major Facilitator superfamily HU175_RS18855 ENOG4108IJ8 ABC transporter HU175_RS18880 ENOG4107QR9 Iron-sulfur cluster binding protein HU175_RS18895 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HU175_RS18900 ENOG4105QJH Domain of unknown function (DUF718) HU175_RS18905 ENOG4105EDR glucose galactose transporter HU175_RS18915 ENOG4105DG6 mannose-6-phosphate isomerase HU175_RS18945 ENOG4109066 lysm domain bon superfamily protein HU175_RS18960 ENOG4105KVH Transcriptional regulator HU175_RS18965 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HU175_RS18970 ENOG4105VFE sira family HU175_RS18985 ENOG4108R6K riboflavin synthase, subunit alpha HU175_RS19035 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HU175_RS19050 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HU175_RS19055 ENOG4105BZU Histidine kinase HU175_RS19080 ENOG4105C98 muts2 protein HU175_RS19085 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HU175_RS19095 ENOG4105EEX Two component transcriptional regulator (Winged helix family HU175_RS19100 ENOG4105RAK Histidine kinase HU175_RS19160 ENOG4105DN9 Na H antiporter HU175_RS19195 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HU175_RS19220 ENOG4105D7N magnesium and cobalt transport protein CorA HU175_RS19225 ENOG4105E4F Isochorismate synthase HU175_RS19240 ENOG4105CKB glycosidase HU175_RS19250 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HU175_RS19265 ENOG4105CDV Ompa motb domain protein HU175_RS19310 ENOG4105BZU Histidine kinase HU175_RS19325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU175_RS19330 ENOG4105DY9 regulatoR HU175_RS19360 ENOG4107VIJ nudix hydrolase HU175_RS19365 ENOG4105E98 transcriptional regulator DeoR family HU175_RS19425 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HU175_RS19430 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HU175_RS19450 ENOG4108UW5 maltose o-acetyltransferase HU175_RS19455 ENOG41061MV Arylsulfatase HU175_RS19460 ENOG41061MV Arylsulfatase HU175_RS19530 ENOG4105C4K Nad synthetase HU175_RS19590 ENOG4105E8G Major facilitator Superfamily HU175_RS19615 ENOG4107VFR oxidoreductase HU175_RS19635 ENOG4105DAP Nicotinate phosphoribosyltransferase HU175_RS19640 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HU175_RS19650 ENOG4105CGU Enoyl-CoA hydratase HU175_RS19675 ENOG4107QJE Chromosome Partitioning Protein HU175_RS19720 ENOG4105G6Z alkaline phosphatase HU175_RS19725 ENOG4105CKI cobalamin synthesis protein HU175_RS19760 ENOG4105CYP glycoside hydrolase, family HU175_RS19765 ENOG4105CYP glycoside hydrolase, family HU175_RS19780 ENOG4105BZU Histidine kinase HU175_RS19785 ENOG4105WH1 Two component transcriptional regulator luxr family HU175_RS19800 ENOG4107RDY Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HU175_RS19820 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HU175_RS19825 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HU175_RS19830 ENOG4105D41 biosynthesis protein thiH HU175_RS19865 ENOG4107SYN Glycosyl hydrolases family 43 HU175_RS19875 ENOG4105EMN RNA polymerase sigma factor HU175_RS19915 ENOG4105C09 Bile acid HU175_RS19920 ENOG4105JSC dimethylmenaquinone methyltransferase HU175_RS19925 ENOG4105CD3 dihydroorotase HU175_RS19935 ENOG4105KME endoribonuclease L-psp HU175_RS19940 ENOG41067HZ cytochrome C, class I HU175_RS19950 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HU175_RS19965 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS19980 ENOG4108RWN rrna methyltransferase HU175_RS19985 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HU175_RS19990 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HU175_RS20000 ENOG4107WT5 transcriptional regulator (NifA HU175_RS20025 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HU175_RS20030 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HU175_RS20035 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HU175_RS20040 ENOG4105CMV Succinyl-CoA synthetase subunit beta HU175_RS20050 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HU175_RS20060 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HU175_RS20065 ENOG4108HHA Transketolase HU175_RS20070 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HU175_RS20080 ENOG4108IUS Transketolase HU175_RS20085 ENOG4105EMN RNA polymerase sigma factor HU175_RS20115 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HU175_RS20125 ENOG4107VXZ Hydrolase HU175_RS20130 ENOG4105DWY Agmatine deiminase HU175_RS20145 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HU175_RS20150 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HU175_RS20155 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HU175_RS20165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HU175_RS20175 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HU175_RS20205 ENOG4105C6Z Gluconate HU175_RS20210 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HU175_RS20225 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HU175_RS20230 ENOG4105IRK Glycosyl transferase (Group 1 HU175_RS20235 ENOG4105BZ1 (ABC) transporter HU175_RS20260 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HU175_RS20265 ENOG4105DY9 regulatoR HU175_RS20270 ENOG4108HRK Histidine kinase HU175_RS20280 ENOG4108YYC ycei family HU175_RS20300 ENOG4107UWA esterase HU175_RS20330 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HU175_RS20335 ENOG4105EN6 Membrane HU175_RS20340 ENOG4108XM1 transcriptional regulator AsnC family HU175_RS20345 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HU175_RS20360 ENOG4108VAC response regulator HU175_RS20390 ENOG4105EXW epimerase dehydratase HU175_RS20395 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HU175_RS20410 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HU175_RS20415 ENOG4105C0H protease HU175_RS20480 ENOG4105K63 Thioredoxin HU175_RS20520 ENOG4105EPC oxidoreductase HU175_RS20530 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HU175_RS20545 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HU175_RS20585 ENOG4105Y7M Transcriptional regulator, TetR family HU175_RS20590 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HU175_RS20640 ENOG4105E1F short-chain dehydrogenase reductase HU175_RS20645 ENOG4105E0C molybdate abc transporter HU175_RS20650 ENOG4108IJ6 ABC transporter HU175_RS20655 ENOG4107R4J Chloride channel HU175_RS20660 ENOG4105C9K Endothelin-converting enzyme 1 HU175_RS20685 ENOG4105D29 Helix-turn-helix type 11 domain protein HU175_RS20705 ENOG4107Y03 Nitroreductase HU175_RS20715 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HU175_RS20720 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HU175_RS20725 ENOG4105DWF phosphomethylpyrimidine kinase HU175_RS20730 ENOG4105ETU transcriptional activator (TenA HU175_RS20765 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HU175_RS20780 ENOG4105EB3 Histidine kinase HU175_RS20800 ENOG4105ENT Efflux transporter rnd family, mfp subunit HU175_RS20865 ENOG4105D70 Integrase catalytic subunit HU175_RS20870 ENOG4105F5W AtP-binding protein HU175_RS20910 ENOG4105EMU Dehydrogenase HU175_RS20915 ENOG4108VB1 regulatoR HU175_RS20920 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS20945 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HU175_RS20970 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HU175_RS21000 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HU175_RS21035 ENOG4106KE4 Dehydrogenase HU175_RS21065 ENOG410841Q phosphoesterase PA-phosphatase related protein HU175_RS21105 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HU175_RS21115 ENOG4105F27 Major Facilitator HU175_RS21125 ENOG4105ES4 Nitrilase HU175_RS21135 ENOG4105C2C drug resistance transporter, Bcr CflA HU175_RS21145 ENOG4105C2M dna polymerase I HU175_RS21160 ENOG4108S4H thioesterase Superfamily protein HU175_RS21185 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HU175_RS21200 ENOG4105D4T Citrate transporter HU175_RS21240 ENOG4105C0B DNA polymerase III (alpha subunit) HU175_RS21280 ENOG4105BZ1 (ABC) transporter HU175_RS21300 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HU175_RS21305 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HU175_RS21320 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HU175_RS21325 ENOG4107SID ATP-dependent exodnase (exonuclease v) HU175_RS21335 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HU175_RS21345 ENOG4105FFC UPF0187 protein HU175_RS21350 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HU175_RS21355 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HU175_RS21360 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HU175_RS21370 ENOG4105CE1 Ferrous iron transport protein b HU175_RS21435 ENOG4105C37 (CBS) domain HU175_RS21440 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HU175_RS21445 ENOG4105DC8 reductase HU175_RS21450 ENOG4105F4R Transcriptional regulator mode HU175_RS21465 ENOG4105C5H ABC transporter HU175_RS21470 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HU175_RS21495 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HU175_RS21505 ENOG4105C1P efflux transporter, rnd family, mfp subunit HU175_RS21515 ENOG4107T66 Releases the N-terminal proline from various substrates (By similarity) HU175_RS21520 ENOG4105E0F Histidine kinase HU175_RS21530 ENOG4105CH2 amidohydrolase HU175_RS21540 ENOG4105W2Z cytochrome C, class I HU175_RS21565 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS21585 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HU175_RS21605 ENOG4107FQ9 ethanolamine ammonia-lyase HU175_RS21615 ENOG4105CPD ethanolamine ammonia-lyase HU175_RS21630 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HU175_RS21635 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HU175_RS21640 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HU175_RS21645 ENOG4105I7S Abortive infection protein HU175_RS21660 ENOG4105K63 Thioredoxin HU175_RS21685 ENOG4107YDW inorganic pyrophosphatase EC 3.6.1.1 HU175_RS21690 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS21695 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HU175_RS21700 ENOG4108B1Q Ribonuclease HU175_RS21710 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HU175_RS21725 ENOG4105U6W MutT NUDIX family protein HU175_RS21735 ENOG4107R5B glutamine synthetase HU175_RS21745 ENOG4105BZU Histidine kinase HU175_RS21755 ENOG4107QHZ cell cycle protein HU175_RS21765 ENOG4108ZF3 Phosphatase HU175_RS21780 ENOG4108IXY short-chain dehydrogenase reductase HU175_RS21785 ENOG4105EMU Dehydrogenase HU175_RS21805 ENOG4108UXN response regulator HU175_RS21810 ENOG4105E3W Two component transcriptional regulator (Winged helix family HU175_RS21845 ENOG4105CHU acetyl-coa acetyltransferase HU175_RS21850 ENOG4107QWK SAICAR synthetase HU175_RS21860 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HU175_RS21865 ENOG4105C8B TIGR00159 family HU175_RS21880 ENOG41082BM Transcriptional regulator, arsr family HU175_RS21890 ENOG4105CS2 ec 3.2.1.21 HU175_RS21900 ENOG4105CYC Transferase HU175_RS21910 ENOG4105CJW magnesium transporter HU175_RS21915 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HU175_RS21975 ENOG4105BZU Histidine kinase HU175_RS22010 ENOG4105CDU Replicative dna helicase HU175_RS22365 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HU175_RS22370 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HU175_RS22375 ENOG4105DJV ribulose-phosphate 3-epimerase HU175_RS22400 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS22405 ENOG4108IUS Transketolase HU175_RS22415 ENOG4105EXC Acyl-transferase HU175_RS22420 ENOG4105CKK Glycosyl transferase, family 2 HU175_RS22440 ENOG4105FJR Lmbe family HU175_RS22480 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HU175_RS22495 ENOG4105DDQ anthranilate synthase HU175_RS22510 ENOG4105C5Q Transcriptional regulator HU175_RS22520 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HU175_RS22545 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HU175_RS22550 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HU175_RS22560 ENOG4105C9F isomerase HU175_RS22620 ENOG4105E0Y RtcB Protein HU175_RS22635 ENOG4105BZP glycoside hydrolase 15-related HU175_RS22645 ENOG4105DU0 nucleoside hydrolase HU175_RS22655 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HU175_RS22670 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HU175_RS22675 ENOG4108V06 Glutathione peroxidase HU175_RS22685 ENOG4105C75 arginyL-tRNA synthetase HU175_RS22695 ENOG4105EMU Dehydrogenase HU175_RS22700 ENOG4105D49 3-dehydroquinate synthase HU175_RS22715 ENOG4105DFH Transport of potassium into the cell (By similarity) HU175_RS22720 ENOG4105C1B dTDP-glucose 4-6-dehydratase HU175_RS22740 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HU175_RS22745 ENOG4106UW1 Major Facilitator superfamily HU175_RS22770 ENOG4105CIB oxidoreductase Domain protein HU175_RS22825 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HU175_RS22835 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU175_RS22845 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HU175_RS22855 ENOG4107RAQ aminopeptidase HU175_RS22885 ENOG4105C1B dTDP-glucose 4-6-dehydratase HU175_RS22890 ENOG4105C6Y Udp-glucose 6-dehydrogenase HU175_RS22900 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HU175_RS22955 ENOG4107R91 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HU175_RS22980 ENOG4105KRQ Addiction module toxin, Txe YoeB family HU175_RS23005 ENOG4105K63 Thioredoxin HU175_RS23020 ENOG41082JN Transcriptional regulator HU175_RS23050 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein HU175_RS23065 ENOG4105CAT Cytidine monophosphate kinase HU175_RS23085 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HU175_RS23090 ENOG4108HRK Histidine kinase HU175_RS23095 ENOG4108VAC response regulator HU175_RS23110 ENOG4105DUX Transporter HU175_RS23130 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HU175_RS23205 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HU175_RS23215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU175_RS23230 ENOG4105BZU Histidine kinase HU175_RS23235 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HU175_RS23245 ENOG4108UJU UPF0301 protein HU175_RS23260 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU175_RS23270 ENOG4107RGD Major Facilitator superfamily HU175_RS23285 ENOG4107RGD Major Facilitator superfamily HU175_RS23290 ENOG4105EXC Acyl-transferase HU175_RS23300 ENOG4108WBT adenosyltransferase HU175_RS23315 ENOG4107QZB decarboxylase HU175_RS23330 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HU175_RS23350 ENOG4105CTK cobaltochelatase, cobn subunit HU175_RS23355 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HU175_RS23370 ENOG4107RNH Outer membrane receptor FepA HU175_RS23385 ENOG4108VAC response regulator HU175_RS23395 ENOG4108HRK Histidine kinase HU175_RS23415 ENOG4105VG0 50S ribosomal protein l34 HU175_RS23420 ENOG4105WG6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HU175_RS23425 ENOG4105CN1 protease HU175_RS23430 ENOG41072GX Peptidase M22 Glycoprotease HU175_RS23450 ENOG4105CRK lysyL-tRNA synthetase HU175_RS23470 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HU175_RS23480 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HU175_RS23485 ENOG4105K63 Thioredoxin HU175_RS23500 ENOG4105DTQ mandelate racemase muconate lactonizing HU175_RS23505 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HU175_RS23510 ENOG4105C3F Signal peptidase i HU175_RS23535 ENOG4105D16 lipopolysaccharide heptosyltransferase i HU175_RS23540 ENOG4106CD9 glycosyl transferase group 1 HU175_RS23550 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HU175_RS23570 ENOG4105BZF Glycosyl transferase (Group 1 HU175_RS23580 ENOG4105EQK -acetyltransferase HU175_RS23595 ENOG4108QV3 biosynthesis protein HU175_RS23625 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HU175_RS23630 ENOG4105CI2 imidazolone-5-propionate hydrolase HU175_RS23640 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HU175_RS23650 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HU175_RS23660 ENOG4105KJF protein tyrosine phosphatase HU175_RS23665 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HU175_RS23670 ENOG4105C7S Dehydrogenase HU175_RS23675 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HU175_RS23680 ENOG4105EYW Ion transport protein HU175_RS23690 ENOG4108VYJ response regulator receiver protein HU175_RS23710 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HU175_RS23740 ENOG4105F4E fad dependent oxidoreductase HU175_RS23745 ENOG4105CTU Proline racemase HU175_RS23750 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HU175_RS23755 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HU175_RS23780 ENOG41065KQ synthase HU175_RS23790 ENOG4105DU1 integral membrane protein, terc HU175_RS23805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HU175_RS23810 ENOG4108ZT0 50S ribosomal protein l17 HU175_RS23815 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HU175_RS23820 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HU175_RS23825 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HU175_RS23830 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HU175_RS23835 ENOG410864M 50S ribosomal protein L36 HU175_RS23840 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HU175_RS23845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HU175_RS23855 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HU175_RS23860 ENOG41084HK 50S ribosomal protein L30 HU175_RS23865 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HU175_RS23870 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HU175_RS23875 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HU175_RS23880 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HU175_RS23885 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HU175_RS23890 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HU175_RS23895 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HU175_RS23900 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HU175_RS23905 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HU175_RS23910 ENOG4108628 50s ribosomal protein l29 HU175_RS23915 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HU175_RS23920 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HU175_RS23925 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HU175_RS23930 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HU175_RS23935 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HU175_RS23940 ENOG41081DX One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HU175_RS23945 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HU175_RS23950 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HU175_RS23955 ENOG4107QN2 dihydrolipoyl dehydrogenase HU175_RS24000 ENOG4108YYC ycei family HU175_RS24015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HU175_RS24030 ENOG4105DUM transcriptional regulator, lysR family HU175_RS24055 ENOG4108V3E phosphoribosylglycinamide formyltransferase HU175_RS24060 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HU175_RS24075 ENOG41063C6 UPF0235 protein HU175_RS24080 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HU175_RS24110 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HU175_RS24115 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HU175_RS24140 ENOG4105CIH Imidazole acetol-phosphate transaminase HU175_RS24160 ENOG4105C4M (Ubiquinol oxidase) subunit I HU175_RS24165 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HU175_RS24170 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HU175_RS24200 ENOG4105KME endoribonuclease L-psp HU175_RS24205 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HU175_RS24240 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HU175_RS24275 ENOG4105C5H ABC transporter HU175_RS24280 ENOG4105DQR SNARE associated Golgi HU175_RS24305 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HU175_RS24310 ENOG4108A04 Beta-lactamase HU175_RS24330 ENOG4105C0P Mg chelatase subunit ChlI HU175_RS24340 ENOG4106VK6 Flagellar motor protein HU175_RS24345 ENOG4107T7F This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HU175_RS24355 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase HU175_RS24365 ENOG4105C27 TonB-dependent Receptor Plug HU175_RS24370 ENOG4105CEP NADH dehydrogenase HU175_RS24385 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HU175_RS24385 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HU175_RS24435 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HU175_RS24450 ENOG4105CEY Amp-dependent synthetase and ligase HU175_RS24460 ENOG4105C6T cysteine synthase HU175_RS24465 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HU175_RS24470 ENOG4105CNU cell division protein FtsK HU175_RS24480 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HU175_RS24490 ENOG4105CFH Aspartokinase HU175_RS24495 ENOG4105C02 permease HU175_RS24505 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HU175_RS24585 ENOG4105Y2X UPF0335 protein HU175_RS24600 ENOG4108UUM single-stranded DNA-binding protein