locus-tag	class	description
HU175_RS00010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HU175_RS00015	COG2819	hydrolase of the alpha beta superfamily
HU175_RS00050	COG1132	(ABC) transporter
HU175_RS00055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HU175_RS00080	COG0237	dephospho-CoA kinase activity
HU175_RS00115	COG0405	Gamma-glutamyltransferase
HU175_RS00120	COG0577	efflux transmembrane transporter activity
HU175_RS00125	COG0366	Alpha amylase catalytic
HU175_RS00130	COG3291	Pkd domain containing protein
HU175_RS00145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HU175_RS00170	COG1629	transport
HU175_RS00190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HU175_RS00195	COG0154	amidase activity
HU175_RS00205	COG0632	four-way junction helicase activity
HU175_RS00210	COG4191	Histidine kinase
HU175_RS00215	COG2204	response regulator
HU175_RS00230	COG0577	efflux transmembrane transporter activity
HU175_RS00235	COG1136	(ABC) transporter
HU175_RS00250	COG4771	TonB-dependent receptor
HU175_RS00300	COG3264	Mechanosensitive ion channel
HU175_RS00300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HU175_RS00310	COG1063	alcohol dehydrogenase
HU175_RS00315	COG1401	restriction endodeoxyribonuclease activity
HU175_RS00330	COG0793	Belongs to the peptidase S41A family
HU175_RS00335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HU175_RS00340	COG1187	pseudouridine synthase activity
HU175_RS00345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HU175_RS00355	COG0477	Major facilitator Superfamily
HU175_RS00375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HU175_RS00380	COG2045	Belongs to the ComB family
HU175_RS00385	COG2133	pyrroloquinoline quinone binding
HU175_RS00390	COG0657	acetylesterase activity
HU175_RS00390	COG2755	lipolytic protein G-D-S-L family
HU175_RS00415	COG1764	response to oxidative stress
HU175_RS00420	COG1846	Transcriptional regulator
HU175_RS00430	COG2814	Major facilitator Superfamily
HU175_RS00445	COG1012	belongs to the aldehyde dehydrogenase family
HU175_RS00465	COG2080	2 iron, 2 sulfur cluster binding
HU175_RS00470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HU175_RS00475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HU175_RS00505	COG1629	transport
HU175_RS00530	COG1959	2 iron, 2 sulfur cluster binding
HU175_RS00565	COG0702	epimerase
HU175_RS00570	COG4771	TonB-dependent receptor
HU175_RS00590	COG0745	RESPONSE REGULATOR receiver
HU175_RS00595	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HU175_RS00600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HU175_RS00610	COG0492	ferredoxin-NADP+ reductase activity
HU175_RS00650	COG0470	DNA polymerase III
HU175_RS00655	COG0189	ligase activity
HU175_RS00655	COG4067	protein conserved in archaea
HU175_RS00660	COG0189	ligase activity
HU175_RS00665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HU175_RS00665	COG4221	oxidoreductase activity
HU175_RS00665	COG0604	alcohol dehydrogenase
HU175_RS00665	COG3321	synthase
HU175_RS00675	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HU175_RS00690	COG1090	epimerase
HU175_RS00695	COG2137	regulation of response to DNA damage stimulus
HU175_RS00715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HU175_RS00720	COG0793	Belongs to the peptidase S41A family
HU175_RS00720	COG4946	Tricorn protease homolog
HU175_RS00730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HU175_RS00790	COG0494	nUDIX hydrolase
HU175_RS00800	COG0287	Prephenate dehydrogenase
HU175_RS00805	COG0667	Aldo Keto reductase
HU175_RS00830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HU175_RS00875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HU175_RS00900	COG0316	Belongs to the HesB IscA family
HU175_RS00945	COG3279	Response regulator of the LytR AlgR family
HU175_RS00970	COG0557	exoribonuclease II activity
HU175_RS00985	COG0321	lipoyl(octanoyl) transferase activity
HU175_RS00990	COG3781	membrane
HU175_RS01035	COG3279	Response regulator of the LytR AlgR family
HU175_RS01040	COG3275	phosphorelay sensor kinase activity
HU175_RS01055	COG0792	nuclease activity
HU175_RS01075	COG1120	ATPase activity
HU175_RS01080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HU175_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS01115	COG1063	alcohol dehydrogenase
HU175_RS01135	COG0668	transmembrane transport
HU175_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS01170	COG2133	pyrroloquinoline quinone binding
HU175_RS01220	COG1297	OPT oligopeptide transporter protein
HU175_RS01230	COG1070	Carbohydrate kinase
HU175_RS01245	COG3119	arylsulfatase activity
HU175_RS01255	COG2115	Belongs to the xylose isomerase family
HU175_RS01275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HU175_RS01280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HU175_RS01310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HU175_RS01320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HU175_RS01325	COG1446	asparaginase
HU175_RS01330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HU175_RS01345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU175_RS01350	COG4771	TonB-dependent receptor
HU175_RS01355	COG1752	Esterase of the alpha-beta hydrolase superfamily
HU175_RS01360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HU175_RS01380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HU175_RS01390	COG0768	penicillin binding
HU175_RS01400	COG2195	Cleaves the N-terminal amino acid of tripeptides
HU175_RS01430	COG1215	transferase activity, transferring glycosyl groups
HU175_RS01475	COG0463	Glycosyl transferase, family 2
HU175_RS01525	COG0463	Glycosyl transferase, family 2
HU175_RS01535	COG0438	transferase activity, transferring glycosyl groups
HU175_RS01540	COG0438	transferase activity, transferring glycosyl groups
HU175_RS01540	COG0297	glycogen (starch) synthase activity
HU175_RS01550	COG2244	polysaccharide biosynthetic process
HU175_RS01555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HU175_RS01560	COG0489	protein tyrosine kinase activity
HU175_RS01560	COG3206	protein involved in exopolysaccharide biosynthesis
HU175_RS01575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HU175_RS01585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HU175_RS01590	COG0564	pseudouridine synthase activity
HU175_RS01600	COG1764	response to oxidative stress
HU175_RS01620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HU175_RS01625	COG0564	pseudouridine synthase activity
HU175_RS01635	COG2378	regulation of single-species biofilm formation
HU175_RS01655	COG0436	Aminotransferase
HU175_RS01670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HU175_RS01705	COG1956	GAF domain-containing protein
HU175_RS01740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HU175_RS01755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HU175_RS01765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HU175_RS01770	COG0129	dihydroxy-acid dehydratase activity
HU175_RS01775	COG0028	Belongs to the TPP enzyme family
HU175_RS01785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HU175_RS01800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HU175_RS01810	COG2361	Protein of unknown function DUF86
HU175_RS01820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HU175_RS01825	COG0066	3-isopropylmalate dehydratase activity
HU175_RS01830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HU175_RS01835	COG0473	3-isopropylmalate dehydrogenase activity
HU175_RS01840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HU175_RS01865	COG0420	3'-5' exonuclease activity
HU175_RS01870	COG0419	ATPase involved in DNA repair
HU175_RS01880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HU175_RS01890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HU175_RS01890	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HU175_RS01900	COG1446	asparaginase
HU175_RS01920	COG3142	Participates in the control of copper homeostasis
HU175_RS01925	COG0788	formyltetrahydrofolate deformylase activity
HU175_RS01935	COG0521	Mo-molybdopterin cofactor biosynthetic process
HU175_RS01940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HU175_RS01945	COG3001	Fructosamine kinase
HU175_RS01950	COG0513	Belongs to the DEAD box helicase family
HU175_RS01965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU175_RS02010	COG2322	membrane
HU175_RS02015	COG1999	signal sequence binding
HU175_RS02030	COG1845	cytochrome c oxidase, subunit III
HU175_RS02035	COG0109	protoheme IX farnesyltransferase activity
HU175_RS02040	COG1612	heme a metabolic process
HU175_RS02045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HU175_RS02050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HU175_RS02075	COG0437	4 iron, 4 sulfur cluster binding
HU175_RS02090	COG0539	negative regulation of cytoplasmic translation
HU175_RS02100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HU175_RS02120	COG0584	glycerophosphoryl diester phosphodiesterase
HU175_RS02135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HU175_RS02140	COG1649	PFAM Uncharacterised BCR, COG1649
HU175_RS02150	COG1522	sequence-specific DNA binding
HU175_RS02165	COG0649	NAD binding
HU175_RS02170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HU175_RS02180	COG0552	protein localization to endoplasmic reticulum
HU175_RS02205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HU175_RS02215	COG2361	Protein of unknown function DUF86
HU175_RS02220	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HU175_RS02225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HU175_RS02230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HU175_RS02285	COG0306	phosphate transporter
HU175_RS02290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HU175_RS02300	COG1610	YqeY-like protein
HU175_RS02305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HU175_RS02320	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HU175_RS02320	COG0662	Cupin 2, conserved barrel domain protein
HU175_RS02325	COG1538	Outer membrane efflux protein
HU175_RS02335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HU175_RS02345	COG2885	chlorophyll binding
HU175_RS02365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HU175_RS02365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HU175_RS02375	COG1215	transferase activity, transferring glycosyl groups
HU175_RS02380	COG1216	Glycosyl transferase, family 2
HU175_RS02405	COG2234	aminopeptidase activity
HU175_RS02415	COG1228	amidohydrolase
HU175_RS02455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HU175_RS02460	COG1160	GTP binding
HU175_RS02480	COG2255	four-way junction helicase activity
HU175_RS02495	COG0527	aspartate kinase activity
HU175_RS02500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HU175_RS02515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HU175_RS02520	COG0051	transcription antitermination factor activity, RNA binding
HU175_RS02525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HU175_RS02535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HU175_RS02560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HU175_RS02570	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HU175_RS02580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HU175_RS02590	COG0300	oxidoreductase activity
HU175_RS02595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HU175_RS02600	COG1127	ABC transporter
HU175_RS02605	COG2373	Large extracellular alpha-helical protein
HU175_RS02610	COG1505	serine-type exopeptidase activity
HU175_RS02620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HU175_RS02620	COG1199	ATP-dependent helicase activity
HU175_RS02645	COG1595	DNA-templated transcription, initiation
HU175_RS02650	COG2264	protein methyltransferase activity
HU175_RS02680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HU175_RS02685	COG0363	glucosamine-6-phosphate deaminase activity
HU175_RS02690	COG0673	inositol 2-dehydrogenase activity
HU175_RS02705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HU175_RS02715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HU175_RS02720	COG0242	peptide deformylase activity
HU175_RS02740	COG1959	2 iron, 2 sulfur cluster binding
HU175_RS02760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HU175_RS02765	COG0531	amino acid
HU175_RS02795	COG1696	Membrane protein involved in D-alanine export
HU175_RS02810	COG0688	phosphatidylethanolamine metabolic process
HU175_RS02820	COG0525	valine-tRNA ligase activity
HU175_RS02840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HU175_RS02850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HU175_RS02875	COG0107	imidazoleglycerol-phosphate synthase activity
HU175_RS02890	COG1132	(ABC) transporter
HU175_RS02900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HU175_RS02910	COG2181	nitrate reductase activity
HU175_RS02910	COG0247	lactate metabolic process
HU175_RS02915	COG2181	nitrate reductase activity
HU175_RS02915	COG0247	lactate metabolic process
HU175_RS02935	COG0194	GDP metabolic process
HU175_RS02940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HU175_RS02950	COG2234	aminopeptidase activity
HU175_RS02955	COG0215	cysteine-tRNA ligase activity
HU175_RS02975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HU175_RS02985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HU175_RS02990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HU175_RS03005	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HU175_RS03020	COG1960	acyl-CoA dehydrogenase activity
HU175_RS03040	COG0626	cystathionine gamma-synthase activity
HU175_RS03045	COG1629	transport
HU175_RS03065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HU175_RS03070	COG0527	aspartate kinase activity
HU175_RS03085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HU175_RS03100	COG0488	(ABC) transporter
HU175_RS03105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HU175_RS03110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HU175_RS03140	COG1012	belongs to the aldehyde dehydrogenase family
HU175_RS03145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HU175_RS03155	COG2226	methyltransferase
HU175_RS03160	COG0445	tRNA wobble uridine modification
HU175_RS03175	COG1040	competence protein
HU175_RS03180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HU175_RS03185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HU175_RS03210	COG0346	lactoylglutathione lyase activity
HU175_RS03215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HU175_RS03220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HU175_RS03290	COG1595	DNA-templated transcription, initiation
HU175_RS03310	COG1435	thymidine kinase activity
HU175_RS03330	COG0783	Belongs to the Dps family
HU175_RS03335	COG0579	oxidoreductase
HU175_RS03345	COG0612	Peptidase, M16
HU175_RS03360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HU175_RS03365	COG0531	amino acid
HU175_RS03375	COG0022	dehydrogenase e1 component
HU175_RS03375	COG0508	dehydrogenase complex catalyzes the overall conversion of
HU175_RS03385	COG0439	Biotin carboxylase
HU175_RS03395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HU175_RS03400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HU175_RS03405	COG0416	fatty acid biosynthetic process
HU175_RS03410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HU175_RS03435	COG0628	permease
HU175_RS03440	COG0745	RESPONSE REGULATOR receiver
HU175_RS03445	COG5002	protein histidine kinase activity
HU175_RS03450	COG0750	zinc metalloprotease
HU175_RS03455	COG0149	triose-phosphate isomerase activity
HU175_RS03485	COG0709	Synthesizes selenophosphate from selenide and ATP
HU175_RS03500	COG1598	PFAM Uncharacterised protein family UPF0150
HU175_RS03510	COG2885	chlorophyll binding
HU175_RS03510	COG3047	cAMP biosynthetic process
HU175_RS03535	COG1629	transport
HU175_RS03535	COG4206	TonB-dependent receptor
HU175_RS03555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HU175_RS03560	COG0571	ribonuclease III activity
HU175_RS03565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HU175_RS03570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HU175_RS03575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HU175_RS03610	COG2972	Histidine kinase
HU175_RS03620	COG2972	Histidine kinase
HU175_RS03630	COG3279	Response regulator of the LytR AlgR family
HU175_RS03655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HU175_RS03665	COG0572	uridine kinase
HU175_RS03670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HU175_RS03675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HU175_RS03680	COG1640	4-alpha-glucanotransferase
HU175_RS03690	COG1136	(ABC) transporter
HU175_RS03710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HU175_RS03715	COG2326	polyphosphate kinase activity
HU175_RS03720	COG2326	polyphosphate kinase activity
HU175_RS03740	COG0138	bifunctional purine biosynthesis protein purh
HU175_RS03750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HU175_RS03765	COG0784	Response regulator, receiver
HU175_RS03775	COG2201	protein-glutamate methylesterase activity
HU175_RS03795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HU175_RS03800	COG0514	ATP-dependent DNA helicase (RecQ)
HU175_RS03805	COG0501	Belongs to the peptidase M48B family
HU175_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS03840	COG2267	carboxylic ester hydrolase activity
HU175_RS03845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HU175_RS03855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HU175_RS03860	COG0134	indole-3-glycerol-phosphate synthase activity
HU175_RS03865	COG0135	phosphoribosylanthranilate isomerase activity
HU175_RS03880	COG0133	tryptophan synthase activity
HU175_RS03885	COG0159	tryptophan synthase activity
HU175_RS03890	COG0140	phosphoribosyl-ATP diphosphatase activity
HU175_RS03890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HU175_RS03905	COG1960	acyl-CoA dehydrogenase activity
HU175_RS03910	COG3409	Peptidoglycan-binding domain 1 protein
HU175_RS03910	COG5632	N-Acetylmuramoyl-L-alanine amidase
HU175_RS03915	COG0183	Belongs to the thiolase family
HU175_RS03920	COG0839	Belongs to the complex I subunit 6 family
HU175_RS03925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS03930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HU175_RS03935	COG1034	ATP synthesis coupled electron transport
HU175_RS03945	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HU175_RS03950	COG0649	NAD binding
HU175_RS03955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS03960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS03965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS03980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HU175_RS03985	COG0563	adenylate kinase activity
HU175_RS04015	COG0811	peptide transport
HU175_RS04050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HU175_RS04065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HU175_RS04085	COG0673	inositol 2-dehydrogenase activity
HU175_RS04095	COG1216	Glycosyl transferase, family 2
HU175_RS04100	COG0531	amino acid
HU175_RS04110	COG0277	FAD linked oxidase domain protein
HU175_RS04110	COG0247	lactate metabolic process
HU175_RS04115	COG1629	transport
HU175_RS04115	COG4206	TonB-dependent receptor
HU175_RS04120	COG0702	epimerase
HU175_RS04150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HU175_RS04160	COG1053	succinate dehydrogenase
HU175_RS04165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HU175_RS04170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HU175_RS04175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HU175_RS04180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HU175_RS04200	COG1017	nitric oxide dioxygenase activity
HU175_RS04200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HU175_RS04215	COG3682	Transcriptional regulator
HU175_RS04255	COG0463	Glycosyl transferase, family 2
HU175_RS04270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HU175_RS04305	COG1472	Belongs to the glycosyl hydrolase 3 family
HU175_RS04330	COG0113	porphobilinogen synthase activity
HU175_RS04335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HU175_RS04410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HU175_RS04415	COG0805	protein transport
HU175_RS04425	COG1473	amidohydrolase
HU175_RS04450	COG1119	ATPase activity
HU175_RS04460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HU175_RS04465	COG1845	cytochrome c oxidase, subunit III
HU175_RS04465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HU175_RS04475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HU175_RS04490	COG0653	protein targeting
HU175_RS04525	COG2244	polysaccharide biosynthetic process
HU175_RS04585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HU175_RS04595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HU175_RS04600	COG2755	lipolytic protein G-D-S-L family
HU175_RS04600	COG0657	acetylesterase activity
HU175_RS04610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HU175_RS04615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HU175_RS04620	COG0811	peptide transport
HU175_RS04625	COG0848	biopolymer transport protein
HU175_RS04640	COG0713	ATP synthesis coupled electron transport
HU175_RS04645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HU175_RS04650	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS04655	COG1007	ATP synthesis coupled electron transport
HU175_RS04685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HU175_RS04690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HU175_RS04710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HU175_RS04715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HU175_RS04730	COG1595	DNA-templated transcription, initiation
HU175_RS04735	COG0517	IMP dehydrogenase activity
HU175_RS04735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HU175_RS04740	COG0514	ATP-dependent DNA helicase (RecQ)
HU175_RS04745	COG0151	Belongs to the GarS family
HU175_RS04750	COG1774	PSP1 C-terminal conserved region
HU175_RS04785	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HU175_RS04785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HU175_RS04795	COG3590	peptidase
HU175_RS04840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HU175_RS04845	COG0081	regulation of translation
HU175_RS04850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HU175_RS04855	COG0222	ribosome binding
HU175_RS04860	COG0085	RNA polymerase activity
HU175_RS04865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HU175_RS04900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HU175_RS04905	COG0049	tRNA binding
HU175_RS04930	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HU175_RS04935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HU175_RS04940	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HU175_RS04945	COG0545	Peptidyl-prolyl cis-trans isomerase
HU175_RS04985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS04995	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HU175_RS05020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HU175_RS05045	COG0358	DNA primase activity
HU175_RS05060	COG3279	Response regulator of the LytR AlgR family
HU175_RS05075	COG1530	ribonuclease E activity
HU175_RS05085	COG0776	regulation of translation
HU175_RS05095	COG0629	single-stranded DNA binding
HU175_RS05100	COG4535	Mg2 and Co2 transporter CorC
HU175_RS05120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HU175_RS05140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HU175_RS05165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HU175_RS05170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HU175_RS05180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HU175_RS05185	COG0105	UTP biosynthetic process
HU175_RS05190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HU175_RS05200	COG1595	DNA-templated transcription, initiation
HU175_RS05210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HU175_RS05215	COG2706	6-phosphogluconolactonase activity
HU175_RS05230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HU175_RS05235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HU175_RS05240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HU175_RS05245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HU175_RS05250	COG0052	Belongs to the universal ribosomal protein uS2 family
HU175_RS05255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HU175_RS05280	COG1970	mechanosensitive ion channel activity
HU175_RS05285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HU175_RS05290	COG0772	Belongs to the SEDS family
HU175_RS05295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HU175_RS05300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HU175_RS05315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HU175_RS05370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HU175_RS05380	COG0534	Mate efflux family protein
HU175_RS05385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HU175_RS05415	COG1162	GTPase activity
HU175_RS05435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HU175_RS05455	COG2912	Transglutaminase-like superfamily
HU175_RS05460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HU175_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS05500	COG0415	Belongs to the DNA photolyase family
HU175_RS05505	COG1704	LemA family
HU175_RS05525	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HU175_RS05530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HU175_RS05545	COG1629	transport
HU175_RS05545	COG4206	TonB-dependent receptor
HU175_RS05560	COG4948	Mandelate Racemase Muconate Lactonizing
HU175_RS05595	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HU175_RS05610	COG1629	transport
HU175_RS05635	COG3537	Alpha-1,2-mannosidase
HU175_RS05655	COG3250	beta-galactosidase activity
HU175_RS05715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HU175_RS05720	COG0297	glycogen (starch) synthase activity
HU175_RS05725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HU175_RS05740	COG0700	Nucleoside recognition
HU175_RS05770	COG1607	acyl-coa hydrolase
HU175_RS05780	COG3920	Histidine kinase
HU175_RS05800	COG4771	TonB-dependent receptor
HU175_RS05805	COG3720	iron ion transport
HU175_RS05810	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HU175_RS05815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HU175_RS05820	COG4558	Periplasmic binding protein
HU175_RS05830	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HU175_RS05840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU175_RS05855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HU175_RS05870	COG4771	TonB-dependent receptor
HU175_RS05875	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU175_RS05895	COG0667	Aldo Keto reductase
HU175_RS05970	COG0492	ferredoxin-NADP+ reductase activity
HU175_RS06020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HU175_RS06035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HU175_RS06040	COG1473	amidohydrolase
HU175_RS06080	COG1104	cysteine desulfurase activity
HU175_RS06105	COG1064	alcohol dehydrogenase
HU175_RS06165	COG0488	(ABC) transporter
HU175_RS06170	COG3781	membrane
HU175_RS06180	COG0012	GTP binding
HU175_RS06200	COG0386	Belongs to the glutathione peroxidase family
HU175_RS06210	COG0205	6-phosphofructokinase activity
HU175_RS06225	COG0438	transferase activity, transferring glycosyl groups
HU175_RS06245	COG2089	acid synthase
HU175_RS06260	COG1083	cytidylyl-transferase
HU175_RS06265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HU175_RS06285	COG1086	Polysaccharide biosynthesis protein
HU175_RS06310	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HU175_RS06335	COG1858	cytochrome C peroxidase
HU175_RS06370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HU175_RS06380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HU175_RS06380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HU175_RS06405	COG3275	phosphorelay sensor kinase activity
HU175_RS06410	COG3279	Response regulator of the LytR AlgR family
HU175_RS06430	COG1131	(ABC) transporter
HU175_RS06450	COG0531	amino acid
HU175_RS06460	COG1131	(ABC) transporter
HU175_RS06475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HU175_RS06490	COG4771	TonB-dependent receptor
HU175_RS06505	COG0612	Peptidase, M16
HU175_RS06510	COG1694	Mazg nucleotide pyrophosphohydrolase
HU175_RS06520	COG1252	NADH dehydrogenase
HU175_RS06525	COG0438	transferase activity, transferring glycosyl groups
HU175_RS06530	COG0640	Transcriptional regulator
HU175_RS06535	COG1902	pentaerythritol trinitrate reductase activity
HU175_RS06540	COG0737	Belongs to the 5'-nucleotidase family
HU175_RS06550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HU175_RS06570	COG0673	inositol 2-dehydrogenase activity
HU175_RS06575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HU175_RS06595	COG4251	negative regulation of phosphorylation
HU175_RS06610	COG0667	Aldo Keto reductase
HU175_RS06615	COG0509	glycine decarboxylation via glycine cleavage system
HU175_RS06620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HU175_RS06675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HU175_RS06700	COG4948	Mandelate Racemase Muconate Lactonizing
HU175_RS06710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HU175_RS06725	COG0612	Peptidase, M16
HU175_RS06740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HU175_RS06755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HU175_RS06770	COG0415	Belongs to the DNA photolyase family
HU175_RS06790	COG0514	ATP-dependent DNA helicase (RecQ)
HU175_RS06800	COG0667	Aldo Keto reductase
HU175_RS06805	COG0517	IMP dehydrogenase activity
HU175_RS06805	COG0516	GMP reductase activity
HU175_RS06835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HU175_RS06835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HU175_RS06840	COG1137	ATPase activity
HU175_RS06850	COG1381	Involved in DNA repair and RecF pathway recombination
HU175_RS06855	COG0179	Fumarylacetoacetate (FAA) hydrolase
HU175_RS06860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HU175_RS06870	COG1136	(ABC) transporter
HU175_RS06870	COG0577	efflux transmembrane transporter activity
HU175_RS06875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HU175_RS06895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HU175_RS06910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HU175_RS06920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HU175_RS06925	COG0314	molybdopterin synthase activity
HU175_RS06935	COG0779	Required for maturation of 30S ribosomal subunits
HU175_RS06940	COG0195	Participates in both transcription termination and antitermination
HU175_RS06945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HU175_RS06945	COG5180	pathogenesis
HU175_RS06965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HU175_RS06970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HU175_RS06980	COG0156	8-amino-7-oxononanoate synthase activity
HU175_RS06995	COG2755	lipolytic protein G-D-S-L family
HU175_RS06995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HU175_RS07005	COG1597	lipid kinase activity
HU175_RS07020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HU175_RS07025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HU175_RS07030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HU175_RS07040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HU175_RS07050	COG2721	sulfolactate sulfo-lyase activity
HU175_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS07060	COG0179	Fumarylacetoacetate (FAA) hydrolase
HU175_RS07075	COG1070	Carbohydrate kinase
HU175_RS07095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HU175_RS07115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HU175_RS07145	COG0284	orotidine-5'-phosphate decarboxylase activity
HU175_RS07170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU175_RS07175	COG4771	TonB-dependent receptor
HU175_RS07200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HU175_RS07210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HU175_RS07220	COG2124	cytochrome p450
HU175_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS07255	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HU175_RS07265	COG2323	membrane
HU175_RS07280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HU175_RS07300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HU175_RS07320	COG0322	excinuclease ABC activity
HU175_RS07345	COG0356	it plays a direct role in the translocation of protons across the membrane
HU175_RS07350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HU175_RS07355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HU175_RS07360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HU175_RS07370	COG0702	epimerase
HU175_RS07375	COG3386	PFAM SMP-30 Gluconolaconase
HU175_RS07385	COG0772	Belongs to the SEDS family
HU175_RS07390	COG3279	Response regulator of the LytR AlgR family
HU175_RS07395	COG2972	Histidine kinase
HU175_RS07395	COG0745	RESPONSE REGULATOR receiver
HU175_RS07430	COG0193	aminoacyl-tRNA hydrolase activity
HU175_RS07435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HU175_RS07445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HU175_RS07450	COG1597	lipid kinase activity
HU175_RS07450	COG1803	Methylglyoxal synthase
HU175_RS07480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HU175_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS07510	COG4771	TonB-dependent receptor
HU175_RS07515	COG0702	epimerase
HU175_RS07535	COG0513	Belongs to the DEAD box helicase family
HU175_RS07570	COG0126	phosphoglycerate kinase activity
HU175_RS07575	COG0745	RESPONSE REGULATOR receiver
HU175_RS07575	COG2205	protein histidine kinase activity
HU175_RS07575	COG3292	Two component regulator propeller
HU175_RS07580	COG1881	PFAM PEBP family protein
HU175_RS07595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HU175_RS07660	COG0346	lactoylglutathione lyase activity
HU175_RS07670	COG0633	Ferredoxin
HU175_RS07670	COG3217	Mosc domain protein beta barrel domain protein
HU175_RS07675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HU175_RS07700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HU175_RS07710	COG1595	DNA-templated transcription, initiation
HU175_RS07720	COG1012	belongs to the aldehyde dehydrogenase family
HU175_RS07740	COG1388	LysM domain
HU175_RS07740	COG3942	CHAP domain
HU175_RS07745	COG4447	cellulose binding
HU175_RS07745	COG4733	cellulase activity
HU175_RS07775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HU175_RS07780	COG2204	response regulator
HU175_RS07785	COG2197	response regulator
HU175_RS07790	COG2884	Cell division ATP-binding protein ftsE
HU175_RS07795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HU175_RS07800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HU175_RS07825	COG5000	phosphorelay sensor kinase activity
HU175_RS07840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HU175_RS07845	COG1183	phosphatidylcholine synthase activity
HU175_RS07850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HU175_RS07855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HU175_RS07860	COG2267	carboxylic ester hydrolase activity
HU175_RS07860	COG2267	carboxylic ester hydrolase activity
HU175_RS07870	COG0584	glycerophosphoryl diester phosphodiesterase
HU175_RS07900	COG0799	negative regulation of ribosome biogenesis
HU175_RS07905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HU175_RS07925	COG0028	Belongs to the TPP enzyme family
HU175_RS07945	COG0277	FAD linked oxidase domain protein
HU175_RS07990	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HU175_RS08095	COG2890	protein-(glutamine-N5) methyltransferase activity
HU175_RS08105	COG0714	Associated with various cellular activities
HU175_RS08115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HU175_RS08125	COG1192	Involved in chromosome partitioning
HU175_RS08130	COG1475	DNA binding
HU175_RS08140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HU175_RS08145	COG0681	Belongs to the peptidase S26 family
HU175_RS08150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HU175_RS08230	COG3956	TIGRFAM MazG family protein
HU175_RS08235	COG0248	Ppx GppA phosphatase
HU175_RS08240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HU175_RS08245	COG4974	Belongs to the 'phage' integrase family
HU175_RS08280	COG0545	Peptidyl-prolyl cis-trans isomerase
HU175_RS08290	COG2151	metal-sulfur cluster biosynthetic enzyme
HU175_RS08310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HU175_RS08315	COG0719	Fe-S assembly protein
HU175_RS08320	COG0396	ATPase activity
HU175_RS08325	COG2235	arginine
HU175_RS08355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HU175_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS08375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HU175_RS08380	COG0745	RESPONSE REGULATOR receiver
HU175_RS08380	COG2205	protein histidine kinase activity
HU175_RS08380	COG3292	Two component regulator propeller
HU175_RS08385	COG4447	cellulose binding
HU175_RS08385	COG4733	cellulase activity
HU175_RS08390	COG2188	Transcriptional regulator
HU175_RS08395	COG2814	Major facilitator Superfamily
HU175_RS08400	COG1629	transport
HU175_RS08405	COG0702	epimerase
HU175_RS08430	COG1940	carbohydrate kinase activity
HU175_RS08440	COG3408	Glycogen debranching enzyme
HU175_RS08440	COG3119	arylsulfatase activity
HU175_RS08450	COG1484	DNA-dependent DNA replication
HU175_RS08455	COG2390	Transcriptional regulator
HU175_RS08455	COG4584	PFAM Integrase catalytic
HU175_RS08470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HU175_RS08490	COG0357	Ribosomal RNA small subunit methyltransferase G
HU175_RS08495	COG1215	transferase activity, transferring glycosyl groups
HU175_RS08500	COG0343	queuine tRNA-ribosyltransferase activity
HU175_RS08515	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HU175_RS08535	COG0297	glycogen (starch) synthase activity
HU175_RS08545	COG0673	inositol 2-dehydrogenase activity
HU175_RS08560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU175_RS08565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HU175_RS08575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HU175_RS08600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HU175_RS08605	COG0492	ferredoxin-NADP+ reductase activity
HU175_RS08615	COG4335	DNA alkylation repair
HU175_RS08620	COG0702	epimerase
HU175_RS08625	COG1629	transport
HU175_RS08630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HU175_RS08640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HU175_RS08660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HU175_RS08685	COG0538	isocitrate dehydrogenase activity
HU175_RS08690	COG3250	beta-galactosidase activity
HU175_RS08720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HU175_RS08755	COG2226	methyltransferase
HU175_RS08775	COG3842	ATPase activity
HU175_RS08780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HU175_RS08785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HU175_RS08785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HU175_RS08790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HU175_RS08795	COG1078	dGTPase activity
HU175_RS08855	COG4733	cellulase activity
HU175_RS08855	COG4447	cellulose binding
HU175_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS08910	COG4181	ATPase activity
HU175_RS08930	COG1253	flavin adenine dinucleotide binding
HU175_RS08935	COG1007	ATP synthesis coupled electron transport
HU175_RS08940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HU175_RS08940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HU175_RS08960	COG1278	Cold shock
HU175_RS08980	COG1132	(ABC) transporter
HU175_RS09010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HU175_RS09020	COG0534	Mate efflux family protein
HU175_RS09030	COG0793	Belongs to the peptidase S41A family
HU175_RS09040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HU175_RS09045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HU175_RS09060	COG0739	heme binding
HU175_RS09065	COG0531	amino acid
HU175_RS09070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HU175_RS09075	COG0083	homoserine kinase activity
HU175_RS09120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HU175_RS09125	COG0584	glycerophosphoryl diester phosphodiesterase
HU175_RS09145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HU175_RS09150	COG1301	dicarboxylic acid transport
HU175_RS09210	COG0247	lactate metabolic process
HU175_RS09210	COG0277	FAD linked oxidase domain protein
HU175_RS09240	COG0577	efflux transmembrane transporter activity
HU175_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS09250	COG1086	Polysaccharide biosynthesis protein
HU175_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS09270	COG0702	epimerase
HU175_RS09275	COG4771	TonB-dependent receptor
HU175_RS09285	COG1228	amidohydrolase
HU175_RS09290	COG4771	TonB-dependent receptor
HU175_RS09315	COG0577	efflux transmembrane transporter activity
HU175_RS09315	COG1136	(ABC) transporter
HU175_RS09320	COG1136	(ABC) transporter
HU175_RS09320	COG0577	efflux transmembrane transporter activity
HU175_RS09325	COG0577	efflux transmembrane transporter activity
HU175_RS09330	COG3279	Response regulator of the LytR AlgR family
HU175_RS09345	COG3275	phosphorelay sensor kinase activity
HU175_RS09350	COG0577	efflux transmembrane transporter activity
HU175_RS09360	COG0577	efflux transmembrane transporter activity
HU175_RS09370	COG3876	Protein conserved in bacteria
HU175_RS09375	COG0577	efflux transmembrane transporter activity
HU175_RS09380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HU175_RS09385	COG0577	efflux transmembrane transporter activity
HU175_RS09390	COG0577	efflux transmembrane transporter activity
HU175_RS09390	COG1136	(ABC) transporter
HU175_RS09395	COG1136	(ABC) transporter
HU175_RS09395	COG0577	efflux transmembrane transporter activity
HU175_RS09400	COG0577	efflux transmembrane transporter activity
HU175_RS09405	COG1136	(ABC) transporter
HU175_RS09405	COG0577	efflux transmembrane transporter activity
HU175_RS09410	COG1136	(ABC) transporter
HU175_RS09410	COG0577	efflux transmembrane transporter activity
HU175_RS09435	COG0577	efflux transmembrane transporter activity
HU175_RS09445	COG1136	(ABC) transporter
HU175_RS09445	COG0577	efflux transmembrane transporter activity
HU175_RS09485	COG4191	Histidine kinase
HU175_RS09490	COG4251	negative regulation of phosphorylation
HU175_RS09530	COG0254	rRNA binding
HU175_RS09535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HU175_RS09535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HU175_RS09560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HU175_RS09570	COG0318	PFAM AMP-dependent synthetase and ligase
HU175_RS09575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HU175_RS09580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HU175_RS09585	COG0187	DNA topoisomerase II activity
HU175_RS09595	COG0686	Belongs to the AlaDH PNT family
HU175_RS09600	COG0802	atpase or kinase
HU175_RS09605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HU175_RS09610	COG1181	Belongs to the D-alanine--D-alanine ligase family
HU175_RS09615	COG0316	Belongs to the HesB IscA family
HU175_RS09615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HU175_RS09620	COG0489	protein tyrosine kinase activity
HU175_RS09635	COG0359	binds to the 23S rRNA
HU175_RS09640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HU175_RS09645	COG0360	Binds together with S18 to 16S ribosomal RNA
HU175_RS09655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HU175_RS09660	COG2363	Small membrane protein
HU175_RS09695	COG1131	(ABC) transporter
HU175_RS09705	COG1725	Transcriptional regulator
HU175_RS09715	COG0288	reversible hydration of carbon dioxide
HU175_RS09720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HU175_RS09725	COG5002	protein histidine kinase activity
HU175_RS09740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HU175_RS09745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HU175_RS09750	COG0671	phosphoesterase, PA-phosphatase related
HU175_RS09765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HU175_RS09780	COG1082	Xylose isomerase domain protein TIM barrel
HU175_RS09785	COG0180	Tryptophanyl-tRNA synthetase
HU175_RS09790	COG0280	phosphate acetyltransferase
HU175_RS09790	COG0281	malic enzyme
HU175_RS09795	COG2050	protein possibly involved in aromatic compounds catabolism
HU175_RS09800	COG0588	phosphoglycerate mutase activity
HU175_RS09805	COG3275	phosphorelay sensor kinase activity
HU175_RS09810	COG3279	Response regulator of the LytR AlgR family
HU175_RS09825	COG0686	Belongs to the AlaDH PNT family
HU175_RS09830	COG1522	sequence-specific DNA binding
HU175_RS09845	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HU175_RS09850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HU175_RS09875	COG3437	response regulator, receiver
HU175_RS09895	COG0259	pyridoxamine-phosphate oxidase activity
HU175_RS09920	COG0366	Alpha amylase catalytic
HU175_RS09925	COG0366	Alpha amylase catalytic
HU175_RS09930	COG4251	negative regulation of phosphorylation
HU175_RS09940	COG0784	Response regulator, receiver
HU175_RS09945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU175_RS09970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HU175_RS09975	COG0673	inositol 2-dehydrogenase activity
HU175_RS09995	COG0564	pseudouridine synthase activity
HU175_RS10025	COG0604	alcohol dehydrogenase
HU175_RS10045	COG0321	lipoyl(octanoyl) transferase activity
HU175_RS10045	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HU175_RS10055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HU175_RS10075	COG3537	Alpha-1,2-mannosidase
HU175_RS10080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HU175_RS10090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HU175_RS10135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HU175_RS10150	COG0300	oxidoreductase activity
HU175_RS10175	COG1902	pentaerythritol trinitrate reductase activity
HU175_RS10180	COG0667	Aldo Keto reductase
HU175_RS10190	COG4585	Histidine kinase
HU175_RS10200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HU175_RS10205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HU175_RS10205	COG1648	precorrin-2 dehydrogenase activity
HU175_RS10215	COG2223	nitrite transmembrane transporter activity
HU175_RS10220	COG0243	molybdopterin cofactor binding
HU175_RS10230	COG2321	neutral zinc metallopeptidase
HU175_RS10240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU175_RS10245	COG4771	TonB-dependent receptor
HU175_RS10270	COG0667	Aldo Keto reductase
HU175_RS10275	COG0024	Methionine aminopeptidase
HU175_RS10280	COG0542	response to heat
HU175_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS10315	COG1570	exodeoxyribonuclease VII activity
HU175_RS10320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HU175_RS10330	COG3279	Response regulator of the LytR AlgR family
HU175_RS10340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HU175_RS10365	COG0662	Cupin 2, conserved barrel domain protein
HU175_RS10365	COG2207	Transcriptional regulator
HU175_RS10375	COG0673	inositol 2-dehydrogenase activity
HU175_RS10380	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HU175_RS10410	COG2323	membrane
HU175_RS10425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HU175_RS10445	COG4712	double-strand break repair protein
HU175_RS10465	COG2211	Major facilitator Superfamily
HU175_RS10480	COG0708	Exodeoxyribonuclease III
HU175_RS10485	COG1187	pseudouridine synthase activity
HU175_RS10490	COG2003	Belongs to the UPF0758 family
HU175_RS10495	COG0268	Binds directly to 16S ribosomal RNA
HU175_RS10525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HU175_RS10530	COG0508	dehydrogenase complex catalyzes the overall conversion of
HU175_RS10535	COG3118	belongs to the thioredoxin family
HU175_RS10545	COG0668	transmembrane transport
HU175_RS10550	COG1104	cysteine desulfurase activity
HU175_RS10570	COG1024	Enoyl-CoA hydratase
HU175_RS10575	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS10585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HU175_RS10590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HU175_RS10600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HU175_RS10610	COG0513	Belongs to the DEAD box helicase family
HU175_RS10615	COG4221	oxidoreductase activity
HU175_RS10645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HU175_RS10650	COG0017	Asparaginyl-tRNA synthetase
HU175_RS10665	COG0346	lactoylglutathione lyase activity
HU175_RS10670	COG2267	carboxylic ester hydrolase activity
HU175_RS10685	COG4974	Belongs to the 'phage' integrase family
HU175_RS10690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HU175_RS10700	COG2095	MarC family integral membrane protein
HU175_RS10720	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HU175_RS10730	COG1058	Belongs to the CinA family
HU175_RS10730	COG1546	Belongs to the CinA family
HU175_RS10745	COG1393	Belongs to the ArsC family
HU175_RS10775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HU175_RS10795	COG0542	response to heat
HU175_RS10835	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS10845	COG0423	glycine-tRNA ligase activity
HU175_RS10850	COG4085	toxin activity
HU175_RS10850	COG1525	nuclease
HU175_RS10850	COG0737	Belongs to the 5'-nucleotidase family
HU175_RS10860	COG3292	Two component regulator propeller
HU175_RS10860	COG0745	RESPONSE REGULATOR receiver
HU175_RS10860	COG2205	protein histidine kinase activity
HU175_RS10860	COG3292	Two component regulator propeller
HU175_RS10860	COG0745	RESPONSE REGULATOR receiver
HU175_RS10860	COG2205	protein histidine kinase activity
HU175_RS10875	COG4152	abc transporter atp-binding protein
HU175_RS10890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HU175_RS10925	COG3685	Protein conserved in bacteria
HU175_RS10945	COG0123	including yeast histone deacetylase and acetoin utilization protein
HU175_RS10955	COG0745	RESPONSE REGULATOR receiver
HU175_RS10955	COG3292	Two component regulator propeller
HU175_RS10955	COG2205	protein histidine kinase activity
HU175_RS10975	COG0564	pseudouridine synthase activity
HU175_RS10995	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HU175_RS11060	COG4993	Dehydrogenase
HU175_RS11075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HU175_RS11080	COG3119	arylsulfatase activity
HU175_RS11095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HU175_RS11100	COG4591	ABC-type transport system involved in lipoprotein release permease component
HU175_RS11110	COG0519	Catalyzes the synthesis of GMP from XMP
HU175_RS11130	COG0738	Major facilitator superfamily
HU175_RS11135	COG0673	inositol 2-dehydrogenase activity
HU175_RS11150	COG0720	synthase
HU175_RS11155	COG0302	gtp cyclohydrolase
HU175_RS11160	COG0823	Involved in the tonB-independent uptake of proteins
HU175_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS11210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HU175_RS11215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU175_RS11240	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HU175_RS11245	COG1621	beta-fructofuranosidase activity
HU175_RS11250	COG1629	transport
HU175_RS11295	COG1960	acyl-CoA dehydrogenase activity
HU175_RS11345	COG1032	radical SAM domain protein
HU175_RS11355	COG4771	TonB-dependent receptor
HU175_RS11370	COG2234	aminopeptidase activity
HU175_RS11370	COG4935	Belongs to the peptidase S8 family
HU175_RS11380	COG0540	Belongs to the ATCase OTCase family
HU175_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS11410	COG4771	TonB-dependent receptor
HU175_RS11440	COG2259	Doxx family
HU175_RS11450	COG0366	Alpha amylase catalytic
HU175_RS11465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU175_RS11470	COG4206	TonB-dependent receptor
HU175_RS11470	COG1629	transport
HU175_RS11495	COG0424	maF-like protein
HU175_RS11510	COG2353	YceI-like domain
HU175_RS11520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HU175_RS11530	COG0071	Belongs to the small heat shock protein (HSP20) family
HU175_RS11535	COG0135	phosphoribosylanthranilate isomerase activity
HU175_RS11540	COG2354	Protein conserved in bacteria
HU175_RS11560	COG0165	Argininosuccinate lyase
HU175_RS11590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HU175_RS11595	COG1845	cytochrome c oxidase, subunit III
HU175_RS11615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HU175_RS11620	COG0246	Mannitol dehydrogenase
HU175_RS11635	COG1312	Catalyzes the dehydration of D-mannonate
HU175_RS11645	COG1904	glucuronate isomerase
HU175_RS11650	COG0596	Alpha beta hydrolase
HU175_RS11665	COG3590	peptidase
HU175_RS11685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HU175_RS11690	COG2361	Protein of unknown function DUF86
HU175_RS11700	COG0429	hydrolase of the alpha beta-hydrolase fold
HU175_RS11720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HU175_RS11725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HU175_RS11730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HU175_RS11745	COG4251	negative regulation of phosphorylation
HU175_RS11750	COG5002	protein histidine kinase activity
HU175_RS11750	COG0784	Response regulator, receiver
HU175_RS11750	COG2198	Histidine kinase
HU175_RS11760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HU175_RS11775	COG3250	beta-galactosidase activity
HU175_RS11785	COG1609	Transcriptional regulator
HU175_RS11795	COG0363	glucosamine-6-phosphate deaminase activity
HU175_RS11820	COG0405	Gamma-glutamyltransferase
HU175_RS11825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU175_RS11830	COG2211	Major facilitator Superfamily
HU175_RS11870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HU175_RS11875	COG2096	Adenosyltransferase
HU175_RS11885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HU175_RS11890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HU175_RS11920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HU175_RS11940	COG3228	Belongs to the MtfA family
HU175_RS11975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU175_RS11995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HU175_RS12000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HU175_RS12010	COG1765	OsmC-like protein
HU175_RS12015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HU175_RS12040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HU175_RS12040	COG1796	DNA polymerase
HU175_RS12060	COG0303	'Molybdopterin
HU175_RS12065	COG0746	molybdenum cofactor guanylyltransferase activity
HU175_RS12065	COG0315	cyclic pyranopterin monophosphate synthase activity
HU175_RS12070	COG0746	molybdenum cofactor guanylyltransferase activity
HU175_RS12085	COG0590	tRNA wobble adenosine to inosine editing
HU175_RS12095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HU175_RS12095	COG2755	lipolytic protein G-D-S-L family
HU175_RS12125	COG1695	Transcriptional regulator
HU175_RS12140	COG1760	l-serine dehydratase
HU175_RS12150	COG2885	chlorophyll binding
HU175_RS12165	COG0481	GTPase activity
HU175_RS12170	COG1522	sequence-specific DNA binding
HU175_RS12175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HU175_RS12180	COG4251	negative regulation of phosphorylation
HU175_RS12185	COG0784	Response regulator, receiver
HU175_RS12190	COG2027	D-alanyl-D-alanine carboxypeptidase
HU175_RS12215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HU175_RS12220	COG0825	malonyl-CoA metabolic process
HU175_RS12260	COG1199	ATP-dependent helicase activity
HU175_RS12260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HU175_RS12270	COG0698	ribose 5-phosphate isomerase
HU175_RS12275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HU175_RS12280	COG1917	Cupin 2, conserved barrel domain protein
HU175_RS12285	COG0363	glucosamine-6-phosphate deaminase activity
HU175_RS12310	COG4773	Receptor
HU175_RS12320	COG2205	protein histidine kinase activity
HU175_RS12325	COG0513	Belongs to the DEAD box helicase family
HU175_RS12330	COG0167	dihydroorotate dehydrogenase activity
HU175_RS12335	COG2271	Major facilitator Superfamily
HU175_RS12350	COG1428	Deoxynucleoside kinase
HU175_RS12370	COG0101	tRNA pseudouridine synthase activity
HU175_RS12410	COG0745	RESPONSE REGULATOR receiver
HU175_RS12415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HU175_RS12460	COG2091	lysine biosynthetic process via aminoadipic acid
HU175_RS12475	COG2244	polysaccharide biosynthetic process
HU175_RS12480	COG0745	RESPONSE REGULATOR receiver
HU175_RS12485	COG5002	protein histidine kinase activity
HU175_RS12500	COG1215	transferase activity, transferring glycosyl groups
HU175_RS12525	COG1673	EVE domain
HU175_RS12570	COG1629	transport
HU175_RS12570	COG4206	TonB-dependent receptor
HU175_RS12585	COG2204	response regulator
HU175_RS12590	COG3158	transport of potassium into the cell
HU175_RS12600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HU175_RS12620	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HU175_RS12630	COG2205	protein histidine kinase activity
HU175_RS12640	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU175_RS12645	COG4771	TonB-dependent receptor
HU175_RS12650	COG2204	response regulator
HU175_RS12715	COG1484	DNA-dependent DNA replication
HU175_RS12720	COG2390	Transcriptional regulator
HU175_RS12720	COG4584	PFAM Integrase catalytic
HU175_RS12755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HU175_RS12760	COG0483	inositol monophosphate 1-phosphatase activity
HU175_RS12785	COG0598	Magnesium transport protein CorA
HU175_RS12790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HU175_RS12795	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HU175_RS12805	COG0784	Response regulator, receiver
HU175_RS12815	COG0025	NhaP-type Na H and K H
HU175_RS12855	COG1253	flavin adenine dinucleotide binding
HU175_RS12865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HU175_RS12870	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HU175_RS12885	COG5002	protein histidine kinase activity
HU175_RS12900	COG4297	protein containing double-stranded beta helix domain
HU175_RS12930	COG2610	gluconate transmembrane transporter activity
HU175_RS12940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HU175_RS12945	COG1349	DNA-binding transcription factor activity
HU175_RS12970	COG3590	peptidase
HU175_RS12980	COG1473	amidohydrolase
HU175_RS12985	COG2311	Membrane
HU175_RS13000	COG3292	Two component regulator propeller
HU175_RS13000	COG2205	protein histidine kinase activity
HU175_RS13000	COG0745	RESPONSE REGULATOR receiver
HU175_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS13015	COG4677	pectinesterase activity
HU175_RS13020	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HU175_RS13025	COG3408	Glycogen debranching enzyme
HU175_RS13025	COG3119	arylsulfatase activity
HU175_RS13055	COG4771	TonB-dependent receptor
HU175_RS13060	COG3292	Two component regulator propeller
HU175_RS13060	COG2205	protein histidine kinase activity
HU175_RS13060	COG0745	RESPONSE REGULATOR receiver
HU175_RS13095	COG0531	amino acid
HU175_RS13105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HU175_RS13115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HU175_RS13125	COG0544	peptidyl-prolyl cis-trans isomerase activity
HU175_RS13160	COG0009	L-threonylcarbamoyladenylate synthase
HU175_RS13170	COG1295	ribonuclease BN
HU175_RS13180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HU175_RS13205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HU175_RS13210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HU175_RS13215	COG1702	phosphate starvation-inducible protein PhoH
HU175_RS13230	COG0658	competence protein
HU175_RS13230	COG2333	competence protein COMEC
HU175_RS13235	COG5634	Uncharacterized conserved protein (DUF2278)
HU175_RS13260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HU175_RS13290	COG2323	membrane
HU175_RS13300	COG4206	TonB-dependent receptor
HU175_RS13320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HU175_RS13380	COG3850	Histidine kinase
HU175_RS13380	COG5002	protein histidine kinase activity
HU175_RS13385	COG0745	RESPONSE REGULATOR receiver
HU175_RS13405	COG2814	Major facilitator Superfamily
HU175_RS13415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HU175_RS13415	COG2207	Transcriptional regulator
HU175_RS13420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HU175_RS13425	COG0494	nUDIX hydrolase
HU175_RS13445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HU175_RS13480	COG0443	Heat shock 70 kDa protein
HU175_RS13490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HU175_RS13505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HU175_RS13570	COG0714	Associated with various cellular activities
HU175_RS13615	COG0312	modulator of DNA gyrase
HU175_RS13650	COG1629	transport
HU175_RS13695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU175_RS13705	COG0004	ammonium transporteR
HU175_RS13710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HU175_RS13715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HU175_RS13725	COG0110	maltose O-acetyltransferase activity
HU175_RS13740	COG0438	transferase activity, transferring glycosyl groups
HU175_RS13740	COG0297	glycogen (starch) synthase activity
HU175_RS13745	COG0438	transferase activity, transferring glycosyl groups
HU175_RS13760	COG0438	transferase activity, transferring glycosyl groups
HU175_RS13790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HU175_RS13790	COG2755	lipolytic protein G-D-S-L family
HU175_RS13795	COG0438	transferase activity, transferring glycosyl groups
HU175_RS13860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HU175_RS13870	COG1193	negative regulation of DNA recombination
HU175_RS13885	COG3546	catalase activity
HU175_RS13905	COG1640	4-alpha-glucanotransferase
HU175_RS13925	COG0228	four-way junction DNA binding
HU175_RS13930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HU175_RS13935	COG0336	Belongs to the RNA methyltransferase TrmD family
HU175_RS13960	COG4771	TonB-dependent receptor
HU175_RS13965	COG0702	epimerase
HU175_RS13985	COG0673	inositol 2-dehydrogenase activity
HU175_RS13990	COG1629	transport
HU175_RS13990	COG4206	TonB-dependent receptor
HU175_RS14000	COG1764	response to oxidative stress
HU175_RS14020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HU175_RS14050	COG0175	sulfate reduction
HU175_RS14055	COG0175	sulfate reduction
HU175_RS14075	COG0730	response to heat
HU175_RS14085	COG0495	leucyl-tRNA aminoacylation
HU175_RS14090	COG1278	Cold shock
HU175_RS14140	COG1959	2 iron, 2 sulfur cluster binding
HU175_RS14150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HU175_RS14150	COG3153	acetyltransferase
HU175_RS14160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU175_RS14160	COG2885	chlorophyll binding
HU175_RS14165	COG3743	rRNA binding
HU175_RS14165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HU175_RS14175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HU175_RS14180	COG1609	Transcriptional regulator
HU175_RS14180	COG2207	Transcriptional regulator
HU175_RS14185	COG0667	Aldo Keto reductase
HU175_RS14190	COG0667	Aldo Keto reductase
HU175_RS14195	COG2223	nitrite transmembrane transporter activity
HU175_RS14205	COG0656	L-ascorbic acid biosynthetic process
HU175_RS14210	COG1064	alcohol dehydrogenase
HU175_RS14215	COG1733	regulation of RNA biosynthetic process
HU175_RS14220	COG0702	epimerase
HU175_RS14225	COG5520	Belongs to the glycosyl hydrolase 30 family
HU175_RS14230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HU175_RS14240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HU175_RS14250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HU175_RS14255	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HU175_RS14260	COG2080	2 iron, 2 sulfur cluster binding
HU175_RS14265	COG0110	maltose O-acetyltransferase activity
HU175_RS14280	COG0667	Aldo Keto reductase
HU175_RS14290	COG0667	Aldo Keto reductase
HU175_RS14315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HU175_RS14355	COG1902	pentaerythritol trinitrate reductase activity
HU175_RS14360	COG4221	oxidoreductase activity
HU175_RS14360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HU175_RS14360	COG0604	alcohol dehydrogenase
HU175_RS14360	COG3321	synthase
HU175_RS14370	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HU175_RS14400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HU175_RS14410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HU175_RS14450	COG0673	inositol 2-dehydrogenase activity
HU175_RS14460	COG0745	RESPONSE REGULATOR receiver
HU175_RS14470	COG0513	Belongs to the DEAD box helicase family
HU175_RS14480	COG3386	PFAM SMP-30 Gluconolaconase
HU175_RS14485	COG0513	Belongs to the DEAD box helicase family
HU175_RS14490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HU175_RS14555	COG0300	oxidoreductase activity
HU175_RS14600	COG2032	superoxide dismutase activity
HU175_RS14605	COG0443	Heat shock 70 kDa protein
HU175_RS14630	COG2270	Major facilitator Superfamily
HU175_RS14645	COG1331	Highly conserved protein containing a thioredoxin domain
HU175_RS14650	COG0432	Pfam Uncharacterised protein family UPF0047
HU175_RS14655	COG0745	RESPONSE REGULATOR receiver
HU175_RS14655	COG3292	Two component regulator propeller
HU175_RS14655	COG0745	RESPONSE REGULATOR receiver
HU175_RS14655	COG2205	protein histidine kinase activity
HU175_RS14655	COG2205	protein histidine kinase activity
HU175_RS14655	COG3292	Two component regulator propeller
HU175_RS14675	COG4206	TonB-dependent receptor
HU175_RS14700	COG0784	Response regulator, receiver
HU175_RS14700	COG5002	protein histidine kinase activity
HU175_RS14700	COG2198	Histidine kinase
HU175_RS14745	COG4251	negative regulation of phosphorylation
HU175_RS14795	COG0668	transmembrane transport
HU175_RS14800	COG2323	membrane
HU175_RS14810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HU175_RS14815	COG3852	Histidine kinase
HU175_RS14825	COG0596	Alpha beta hydrolase
HU175_RS14870	COG4977	sequence-specific DNA binding
HU175_RS14870	COG1917	Cupin 2, conserved barrel domain protein
HU175_RS14875	COG3604	Transcriptional regulator
HU175_RS14895	COG3920	Histidine kinase
HU175_RS14910	COG0604	alcohol dehydrogenase
HU175_RS14920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HU175_RS14925	COG0346	lactoylglutathione lyase activity
HU175_RS14930	COG0596	Alpha beta hydrolase
HU175_RS14945	COG4977	sequence-specific DNA binding
HU175_RS14955	COG1611	Belongs to the LOG family
HU175_RS14990	COG0305	Participates in initiation and elongation during chromosome replication
HU175_RS15000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU175_RS15015	COG2259	Doxx family
HU175_RS15030	COG1012	belongs to the aldehyde dehydrogenase family
HU175_RS15060	COG0067	glutamate synthase
HU175_RS15060	COG0070	glutamate synthase
HU175_RS15060	COG0069	glutamate synthase activity
HU175_RS15070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HU175_RS15100	COG0442	prolyl-tRNA aminoacylation
HU175_RS15120	COG1047	Peptidyl-prolyl cis-trans
HU175_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS15160	COG3250	beta-galactosidase activity
HU175_RS15170	COG1663	tetraacyldisaccharide 4'-kinase activity
HU175_RS15175	COG4948	Mandelate Racemase Muconate Lactonizing
HU175_RS15180	COG0408	coproporphyrinogen oxidase activity
HU175_RS15220	COG2814	Major facilitator Superfamily
HU175_RS15305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HU175_RS15320	COG3250	beta-galactosidase activity
HU175_RS15350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HU175_RS15355	COG1185	polyribonucleotide nucleotidyltransferase activity
HU175_RS15360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HU175_RS15405	COG0504	CTP synthase activity
HU175_RS15410	COG0706	membrane insertase activity
HU175_RS15420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HU175_RS15430	COG1216	Glycosyl transferase, family 2
HU175_RS15445	COG0124	histidyl-tRNA synthetase
HU175_RS15480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HU175_RS15480	COG1648	precorrin-2 dehydrogenase activity
HU175_RS15485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HU175_RS15515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HU175_RS15530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HU175_RS15540	COG2171	N-acyltransferase activity
HU175_RS15560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HU175_RS15600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HU175_RS15605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HU175_RS15610	COG0640	Transcriptional regulator
HU175_RS15615	COG5658	integral membrane protein
HU175_RS15675	COG2304	oxidoreductase activity
HU175_RS15680	COG0753	catalase activity
HU175_RS15690	COG2133	pyrroloquinoline quinone binding
HU175_RS15700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HU175_RS15705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HU175_RS15710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HU175_RS15715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HU175_RS15725	COG0116	Belongs to the methyltransferase superfamily
HU175_RS15725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HU175_RS15745	COG2949	membrane
HU175_RS15765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HU175_RS15770	COG2154	pterin-4-alpha-carbinolamine dehydratase
HU175_RS15775	COG4251	negative regulation of phosphorylation
HU175_RS15790	COG4251	negative regulation of phosphorylation
HU175_RS15805	COG0436	Aminotransferase
HU175_RS15825	COG4948	Mandelate Racemase Muconate Lactonizing
HU175_RS15830	COG1629	transport
HU175_RS15830	COG4206	TonB-dependent receptor
HU175_RS15840	COG4948	Mandelate Racemase Muconate Lactonizing
HU175_RS15850	COG4771	TonB-dependent receptor
HU175_RS15865	COG4993	Dehydrogenase
HU175_RS15870	COG3734	2-keto-3-deoxy-galactonokinase
HU175_RS15875	COG0800	Aldolase
HU175_RS15880	COG2271	Major facilitator Superfamily
HU175_RS15920	COG2133	pyrroloquinoline quinone binding
HU175_RS15925	COG1045	serine acetyltransferase
HU175_RS15940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HU175_RS15950	COG1940	carbohydrate kinase activity
HU175_RS15955	COG2135	peptidase activity
HU175_RS15960	COG0259	pyridoxamine-phosphate oxidase activity
HU175_RS15975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HU175_RS15985	COG1063	alcohol dehydrogenase
HU175_RS15990	COG0484	heat shock protein binding
HU175_RS15995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HU175_RS16000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HU175_RS16010	COG3844	kynureninase activity
HU175_RS16065	COG0702	epimerase
HU175_RS16070	COG1629	transport
HU175_RS16070	COG4206	TonB-dependent receptor
HU175_RS16085	COG0339	signal peptide processing
HU175_RS16090	COG0110	maltose O-acetyltransferase activity
HU175_RS16100	COG2205	protein histidine kinase activity
HU175_RS16120	COG4251	negative regulation of phosphorylation
HU175_RS16125	COG4251	negative regulation of phosphorylation
HU175_RS16130	COG2312	Erythromycin esterase
HU175_RS16190	COG4584	PFAM Integrase catalytic
HU175_RS16190	COG2390	Transcriptional regulator
HU175_RS16195	COG1484	DNA-dependent DNA replication
HU175_RS16235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HU175_RS16240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HU175_RS16245	COG2080	2 iron, 2 sulfur cluster binding
HU175_RS16270	COG1858	cytochrome C peroxidase
HU175_RS16290	COG1785	Belongs to the alkaline phosphatase family
HU175_RS16290	COG1785	Belongs to the alkaline phosphatase family
HU175_RS16310	COG1301	dicarboxylic acid transport
HU175_RS16325	COG3237	CsbD-like
HU175_RS16330	COG0612	Peptidase, M16
HU175_RS16340	COG0697	spore germination
HU175_RS16350	COG0129	dihydroxy-acid dehydratase activity
HU175_RS16360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HU175_RS16370	COG0739	heme binding
HU175_RS16370	COG0741	lytic transglycosylase activity
HU175_RS16370	COG1196	nuclear chromosome segregation
HU175_RS16375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HU175_RS16380	COG1127	ABC transporter
HU175_RS16400	COG4771	TonB-dependent receptor
HU175_RS16435	COG1917	Cupin 2, conserved barrel domain protein
HU175_RS16435	COG2169	Transcriptional regulator
HU175_RS16465	COG1733	regulation of RNA biosynthetic process
HU175_RS16495	COG0009	L-threonylcarbamoyladenylate synthase
HU175_RS16500	COG4251	negative regulation of phosphorylation
HU175_RS16510	COG0564	pseudouridine synthase activity
HU175_RS16520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HU175_RS16530	COG1609	Transcriptional regulator
HU175_RS16540	COG3661	Belongs to the glycosyl hydrolase 67 family
HU175_RS16545	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS16575	COG3693	PFAM glycoside hydrolase, family 10
HU175_RS16575	COG3507	Belongs to the glycosyl hydrolase 43 family
HU175_RS16575	COG2382	esterase
HU175_RS16580	COG2382	esterase
HU175_RS16585	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HU175_RS16590	COG2382	esterase
HU175_RS16590	COG3693	PFAM glycoside hydrolase, family 10
HU175_RS16595	COG3507	Belongs to the glycosyl hydrolase 43 family
HU175_RS16595	COG3693	PFAM glycoside hydrolase, family 10
HU175_RS16595	COG2382	esterase
HU175_RS16600	COG2382	esterase
HU175_RS16605	COG0657	acetylesterase activity
HU175_RS16605	COG2755	lipolytic protein G-D-S-L family
HU175_RS16610	COG2382	esterase
HU175_RS16620	COG3507	Belongs to the glycosyl hydrolase 43 family
HU175_RS16625	COG1082	Xylose isomerase domain protein TIM barrel
HU175_RS16660	COG4771	TonB-dependent receptor
HU175_RS16680	COG2160	L-arabinose isomerase activity
HU175_RS16705	COG0745	RESPONSE REGULATOR receiver
HU175_RS16710	COG2205	protein histidine kinase activity
HU175_RS16745	COG4221	oxidoreductase activity
HU175_RS16795	COG0305	Participates in initiation and elongation during chromosome replication
HU175_RS16825	COG0492	ferredoxin-NADP+ reductase activity
HU175_RS16830	COG0739	heme binding
HU175_RS16845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HU175_RS16850	COG2086	electron transfer activity
HU175_RS16865	COG1914	H( )-stimulated, divalent metal cation uptake system
HU175_RS16870	COG0783	Belongs to the Dps family
HU175_RS16875	COG0604	alcohol dehydrogenase
HU175_RS16875	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS16875	COG3321	synthase
HU175_RS16895	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HU175_RS16905	COG3047	cAMP biosynthetic process
HU175_RS16905	COG2885	chlorophyll binding
HU175_RS16915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HU175_RS16935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HU175_RS16940	COG3250	beta-galactosidase activity
HU175_RS16960	COG0702	epimerase
HU175_RS16965	COG4771	TonB-dependent receptor
HU175_RS16970	COG1609	Transcriptional regulator
HU175_RS16995	COG0628	permease
HU175_RS17015	COG2610	gluconate transmembrane transporter activity
HU175_RS17035	COG1629	transport
HU175_RS17040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HU175_RS17055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HU175_RS17060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HU175_RS17070	COG1809	phosphosulfolactate synthase activity
HU175_RS17075	COG0586	Pfam SNARE associated Golgi protein
HU175_RS17080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HU175_RS17090	COG3757	hydrolase, family 25
HU175_RS17100	COG0450	alkyl hydroperoxide reductase
HU175_RS17105	COG2197	response regulator
HU175_RS17110	COG4585	Histidine kinase
HU175_RS17125	COG1278	Cold shock
HU175_RS17135	COG0791	NLP P60 protein
HU175_RS17185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HU175_RS17190	COG1605	Chorismate mutase
HU175_RS17190	COG0077	Prephenate dehydratase
HU175_RS17210	COG1404	Belongs to the peptidase S8 family
HU175_RS17215	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HU175_RS17270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HU175_RS17280	COG0693	protein deglycase activity
HU175_RS17285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HU175_RS17295	COG1074	ATP-dependent DNA helicase activity
HU175_RS17305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HU175_RS17310	COG0242	peptide deformylase activity
HU175_RS17325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HU175_RS17330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HU175_RS17345	COG3279	Response regulator of the LytR AlgR family
HU175_RS17350	COG0602	queuosine metabolic process
HU175_RS17360	COG2217	Heavy metal translocating P-type atpase
HU175_RS17450	COG0823	Involved in the tonB-independent uptake of proteins
HU175_RS17450	COG1506	peptidase
HU175_RS17470	COG2272	Belongs to the type-B carboxylesterase lipase family
HU175_RS17565	COG2390	Transcriptional regulator
HU175_RS17565	COG4584	PFAM Integrase catalytic
HU175_RS17575	COG1484	DNA-dependent DNA replication
HU175_RS17580	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HU175_RS17605	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS17610	COG2885	chlorophyll binding
HU175_RS17615	COG0037	tRNA processing
HU175_RS17650	COG0497	DNA recombination
HU175_RS17660	COG1999	signal sequence binding
HU175_RS17680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HU175_RS17685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HU175_RS17700	COG0673	inositol 2-dehydrogenase activity
HU175_RS17710	COG3940	Belongs to the glycosyl hydrolase 43 family
HU175_RS17715	COG3254	rhamnose metabolic process
HU175_RS17720	COG1490	D-aminoacyl-tRNA deacylase activity
HU175_RS17730	COG1388	LysM domain
HU175_RS17730	COG1705	Flagellar rod assembly protein muramidase FlgJ
HU175_RS17745	COG1648	precorrin-2 dehydrogenase activity
HU175_RS17745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HU175_RS17780	COG0745	RESPONSE REGULATOR receiver
HU175_RS17785	COG5002	protein histidine kinase activity
HU175_RS17790	COG3264	Mechanosensitive ion channel
HU175_RS17790	COG1196	nuclear chromosome segregation
HU175_RS17805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU175_RS17850	COG4106	trans-aconitate 2-methyltransferase activity
HU175_RS17870	COG4251	negative regulation of phosphorylation
HU175_RS17890	COG0577	efflux transmembrane transporter activity
HU175_RS17890	COG1136	(ABC) transporter
HU175_RS17910	COG2081	HI0933 family
HU175_RS17915	COG0196	riboflavin kinase activity
HU175_RS17920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HU175_RS17925	COG1968	undecaprenyl-diphosphatase activity
HU175_RS17935	COG2177	Part of the ABC transporter FtsEX involved in
HU175_RS17945	COG1621	beta-fructofuranosidase activity
HU175_RS17970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HU175_RS17975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HU175_RS17980	COG0655	NAD(P)H dehydrogenase (quinone) activity
HU175_RS17995	COG4206	TonB-dependent receptor
HU175_RS17995	COG1629	transport
HU175_RS18010	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HU175_RS18035	COG0791	NLP P60 protein
HU175_RS18040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HU175_RS18045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HU175_RS18050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HU175_RS18075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HU175_RS18090	COG1363	Peptidase, m42
HU175_RS18130	COG5285	phytanoyl-CoA dioxygenase
HU175_RS18140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HU175_RS18150	COG0640	Transcriptional regulator
HU175_RS18160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HU175_RS18160	COG1321	iron dependent repressor
HU175_RS18180	COG1215	transferase activity, transferring glycosyl groups
HU175_RS18190	COG0463	Glycosyl transferase, family 2
HU175_RS18195	COG0463	Glycosyl transferase, family 2
HU175_RS18205	COG1696	Membrane protein involved in D-alanine export
HU175_RS18235	COG4771	TonB-dependent receptor
HU175_RS18245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HU175_RS18270	COG2308	Evidence 4 Homologs of previously reported genes of
HU175_RS18290	COG0019	diaminopimelate decarboxylase activity
HU175_RS18295	COG2252	PERMEase
HU175_RS18300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HU175_RS18330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HU175_RS18360	COG0463	Glycosyl transferase, family 2
HU175_RS18385	COG2814	Major facilitator Superfamily
HU175_RS18390	COG1619	proteins homologs of microcin C7 resistance protein MccF
HU175_RS18475	COG0477	Major facilitator Superfamily
HU175_RS18505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HU175_RS18515	COG0519	Catalyzes the synthesis of GMP from XMP
HU175_RS18515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HU175_RS18525	COG3876	Protein conserved in bacteria
HU175_RS18530	COG0577	efflux transmembrane transporter activity
HU175_RS18550	COG0531	amino acid
HU175_RS18565	COG3279	Response regulator of the LytR AlgR family
HU175_RS18575	COG0579	oxidoreductase
HU175_RS18580	COG0405	Gamma-glutamyltransferase
HU175_RS18600	COG1715	Restriction endonuclease
HU175_RS18610	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS18660	COG0450	alkyl hydroperoxide reductase
HU175_RS18675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HU175_RS18685	COG1215	transferase activity, transferring glycosyl groups
HU175_RS18690	COG0726	polysaccharide deacetylase
HU175_RS18700	COG0084	hydrolase, TatD family'
HU175_RS18705	COG0252	asparaginase activity
HU175_RS18790	COG0492	ferredoxin-NADP+ reductase activity
HU175_RS18800	COG0393	Putative heavy-metal-binding
HU175_RS18815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HU175_RS18820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HU175_RS18825	COG1561	YicC-like family, N-terminal region
HU175_RS18835	COG2094	Belongs to the DNA glycosylase MPG family
HU175_RS18840	COG2814	Major facilitator Superfamily
HU175_RS18855	COG0517	IMP dehydrogenase activity
HU175_RS18855	COG1125	glycine betaine transport
HU175_RS18880	COG1139	Iron-sulfur cluster binding protein
HU175_RS18895	COG0247	lactate metabolic process
HU175_RS18900	COG3254	rhamnose metabolic process
HU175_RS18905	COG0738	Major facilitator superfamily
HU175_RS18915	COG1482	cell wall glycoprotein biosynthetic process
HU175_RS18945	COG1652	LysM domain
HU175_RS18960	COG1733	regulation of RNA biosynthetic process
HU175_RS18965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HU175_RS18970	COG0425	Belongs to the sulfur carrier protein TusA family
HU175_RS18970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HU175_RS18985	COG0307	riboflavin synthase, alpha
HU175_RS18995	COG0463	Glycosyl transferase, family 2
HU175_RS19035	COG1418	mRNA catabolic process
HU175_RS19055	COG4251	negative regulation of phosphorylation
HU175_RS19080	COG1193	negative regulation of DNA recombination
HU175_RS19085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU175_RS19095	COG0745	RESPONSE REGULATOR receiver
HU175_RS19100	COG3920	Histidine kinase
HU175_RS19125	COG1629	transport
HU175_RS19160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HU175_RS19185	COG1506	peptidase
HU175_RS19195	COG0101	tRNA pseudouridine synthase activity
HU175_RS19220	COG0598	Magnesium transport protein CorA
HU175_RS19225	COG1169	isochorismate synthase
HU175_RS19240	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HU175_RS19250	COG0823	Involved in the tonB-independent uptake of proteins
HU175_RS19250	COG1506	peptidase
HU175_RS19310	COG3852	Histidine kinase
HU175_RS19315	COG0784	Response regulator, receiver
HU175_RS19325	COG2204	response regulator
HU175_RS19360	COG0494	nUDIX hydrolase
HU175_RS19365	COG1349	DNA-binding transcription factor activity
HU175_RS19425	COG1518	maintenance of DNA repeat elements
HU175_RS19430	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HU175_RS19450	COG0110	maltose O-acetyltransferase activity
HU175_RS19455	COG3119	arylsulfatase activity
HU175_RS19460	COG3119	arylsulfatase activity
HU175_RS19465	COG0702	epimerase
HU175_RS19470	COG1629	transport
HU175_RS19530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HU175_RS19530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HU175_RS19540	COG3511	phospholipase C
HU175_RS19575	COG1629	transport
HU175_RS19585	COG1846	Transcriptional regulator
HU175_RS19615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HU175_RS19635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HU175_RS19650	COG1024	Enoyl-CoA hydratase
HU175_RS19675	COG1192	Involved in chromosome partitioning
HU175_RS19685	COG2197	response regulator
HU175_RS19720	COG1785	Belongs to the alkaline phosphatase family
HU175_RS19725	COG0523	cobalamin synthesis protein
HU175_RS19775	COG2205	protein histidine kinase activity
HU175_RS19775	COG3292	Two component regulator propeller
HU175_RS19775	COG0745	RESPONSE REGULATOR receiver
HU175_RS19785	COG2197	response regulator
HU175_RS19800	COG0083	homoserine kinase activity
HU175_RS19820	COG0352	thiamine-phosphate diphosphorylase activity
HU175_RS19825	COG2022	thiamine diphosphate biosynthetic process
HU175_RS19830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HU175_RS19865	COG3507	Belongs to the glycosyl hydrolase 43 family
HU175_RS19920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HU175_RS19935	COG0251	oxidation-reduction process
HU175_RS19950	COG1921	L-seryl-tRNASec selenium transferase activity
HU175_RS19965	COG4206	TonB-dependent receptor
HU175_RS19965	COG1629	transport
HU175_RS19980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HU175_RS19985	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HU175_RS19990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HU175_RS20000	COG3604	Transcriptional regulator
HU175_RS20025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HU175_RS20030	COG0459	protein refolding
HU175_RS20035	COG1136	(ABC) transporter
HU175_RS20040	COG0045	succinate-CoA ligase (ADP-forming) activity
HU175_RS20050	COG0179	Fumarylacetoacetate (FAA) hydrolase
HU175_RS20060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HU175_RS20065	COG3959	Transketolase, thiamine diphosphate binding domain
HU175_RS20070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HU175_RS20080	COG3958	Transketolase
HU175_RS20085	COG1595	DNA-templated transcription, initiation
HU175_RS20115	COG0482	sulfurtransferase activity
HU175_RS20125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU175_RS20130	COG2957	Belongs to the agmatine deiminase family
HU175_RS20145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HU175_RS20150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HU175_RS20155	COG0714	Associated with various cellular activities
HU175_RS20165	COG3842	ATPase activity
HU175_RS20175	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS20205	COG2610	gluconate transmembrane transporter activity
HU175_RS20215	COG1940	carbohydrate kinase activity
HU175_RS20225	COG0438	transferase activity, transferring glycosyl groups
HU175_RS20230	COG0438	transferase activity, transferring glycosyl groups
HU175_RS20235	COG1132	(ABC) transporter
HU175_RS20260	COG2852	Protein conserved in bacteria
HU175_RS20265	COG3279	Response regulator of the LytR AlgR family
HU175_RS20270	COG3275	phosphorelay sensor kinase activity
HU175_RS20280	COG2353	YceI-like domain
HU175_RS20320	COG1629	transport
HU175_RS20330	COG1473	amidohydrolase
HU175_RS20340	COG1522	sequence-specific DNA binding
HU175_RS20345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HU175_RS20390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU175_RS20395	COG0156	8-amino-7-oxononanoate synthase activity
HU175_RS20410	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS20415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HU175_RS20445	COG0702	epimerase
HU175_RS20450	COG4771	TonB-dependent receptor
HU175_RS20485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HU175_RS20520	COG0673	inositol 2-dehydrogenase activity
HU175_RS20545	COG0673	inositol 2-dehydrogenase activity
HU175_RS20585	COG1309	transcriptional regulator
HU175_RS20620	COG4771	TonB-dependent receptor
HU175_RS20625	COG0702	epimerase
HU175_RS20640	COG0300	oxidoreductase activity
HU175_RS20650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HU175_RS20655	COG0038	chloride channel
HU175_RS20660	COG3590	peptidase
HU175_RS20685	COG2378	regulation of single-species biofilm formation
HU175_RS20705	COG0778	Nitroreductase
HU175_RS20715	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HU175_RS20720	COG0352	thiamine-phosphate diphosphorylase activity
HU175_RS20725	COG0351	phosphomethylpyrimidine kinase
HU175_RS20725	COG0352	thiamine-phosphate diphosphorylase activity
HU175_RS20730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HU175_RS20755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HU175_RS20765	COG2010	Cytochrome c
HU175_RS20765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HU175_RS20780	COG2205	protein histidine kinase activity
HU175_RS20800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU175_RS20865	COG2390	Transcriptional regulator
HU175_RS20865	COG4584	PFAM Integrase catalytic
HU175_RS20870	COG1484	DNA-dependent DNA replication
HU175_RS20900	COG1733	regulation of RNA biosynthetic process
HU175_RS20910	COG4221	oxidoreductase activity
HU175_RS20915	COG2197	response regulator
HU175_RS20920	COG4206	TonB-dependent receptor
HU175_RS20920	COG1629	transport
HU175_RS20970	COG0588	phosphoglycerate mutase activity
HU175_RS21000	COG3384	dioxygenase
HU175_RS21010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HU175_RS21035	COG2084	Dehydrogenase
HU175_RS21065	COG0671	phosphoesterase, PA-phosphatase related
HU175_RS21105	COG3507	Belongs to the glycosyl hydrolase 43 family
HU175_RS21115	COG2814	Major facilitator Superfamily
HU175_RS21125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HU175_RS21135	COG2814	Major facilitator Superfamily
HU175_RS21145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HU175_RS21145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HU175_RS21150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HU175_RS21160	COG1607	acyl-coa hydrolase
HU175_RS21200	COG2851	Citrate transporter
HU175_RS21280	COG1132	(ABC) transporter
HU175_RS21295	COG1253	flavin adenine dinucleotide binding
HU175_RS21305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HU175_RS21320	COG0516	GMP reductase activity
HU175_RS21320	COG0517	IMP dehydrogenase activity
HU175_RS21325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HU175_RS21335	COG0326	Molecular chaperone. Has ATPase activity
HU175_RS21345	COG3781	membrane
HU175_RS21350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HU175_RS21355	COG0335	large ribosomal subunit rRNA binding
HU175_RS21360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HU175_RS21360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HU175_RS21435	COG1253	flavin adenine dinucleotide binding
HU175_RS21440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HU175_RS21465	COG0488	(ABC) transporter
HU175_RS21470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HU175_RS21495	COG1538	Outer membrane efflux protein
HU175_RS21505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU175_RS21515	COG2267	carboxylic ester hydrolase activity
HU175_RS21520	COG2205	protein histidine kinase activity
HU175_RS21530	COG1473	amidohydrolase
HU175_RS21540	COG4654	Cytochrome c, class I
HU175_RS21555	COG2169	Transcriptional regulator
HU175_RS21565	COG1629	transport
HU175_RS21565	COG4206	TonB-dependent receptor
HU175_RS21585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HU175_RS21600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HU175_RS21600	COG0758	DNA mediated transformation
HU175_RS21605	COG4302	ethanolamine ammonia-lyase activity
HU175_RS21630	COG0233	cytoplasmic translational termination
HU175_RS21635	COG0528	UMP kinase activity
HU175_RS21640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HU175_RS21645	COG1266	CAAX protease self-immunity
HU175_RS21680	COG0616	signal peptide processing
HU175_RS21685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HU175_RS21690	COG0463	Glycosyl transferase, family 2
HU175_RS21695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HU175_RS21700	COG0328	RNA-DNA hybrid ribonuclease activity
HU175_RS21700	COG3341	Caulimovirus viroplasmin
HU175_RS21705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HU175_RS21710	COG2195	Cleaves the N-terminal amino acid of tripeptides
HU175_RS21725	COG4112	unkown
HU175_RS21735	COG0174	glutamine synthetase
HU175_RS21745	COG4251	negative regulation of phosphorylation
HU175_RS21755	COG0772	Belongs to the SEDS family
HU175_RS21765	COG0631	protein serine/threonine phosphatase activity
HU175_RS21780	COG0300	oxidoreductase activity
HU175_RS21785	COG4221	oxidoreductase activity
HU175_RS21800	COG4251	negative regulation of phosphorylation
HU175_RS21805	COG0784	Response regulator, receiver
HU175_RS21810	COG0745	RESPONSE REGULATOR receiver
HU175_RS21845	COG0183	Belongs to the thiolase family
HU175_RS21850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HU175_RS21860	COG1234	tRNA 3'-trailer cleavage
HU175_RS21865	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HU175_RS21880	COG0640	Transcriptional regulator
HU175_RS21890	COG2723	6-phospho-beta-galactosidase activity
HU175_RS21900	COG0427	acetyl-CoA hydrolase
HU175_RS21910	COG2239	Acts as a magnesium transporter
HU175_RS21915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HU175_RS21975	COG4999	Histidine kinase
HU175_RS21975	COG3850	Histidine kinase
HU175_RS21975	COG3437	response regulator, receiver
HU175_RS21975	COG2205	protein histidine kinase activity
HU175_RS22010	COG0305	Participates in initiation and elongation during chromosome replication
HU175_RS22275	COG0740	serine-type endopeptidase activity
HU175_RS22365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HU175_RS22370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HU175_RS22375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HU175_RS22395	COG3959	Transketolase, thiamine diphosphate binding domain
HU175_RS22400	COG0463	Glycosyl transferase, family 2
HU175_RS22405	COG3958	Transketolase
HU175_RS22420	COG1215	transferase activity, transferring glycosyl groups
HU175_RS22425	COG2072	flavoprotein involved in K transport
HU175_RS22440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HU175_RS22445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HU175_RS22455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HU175_RS22455	COG0517	IMP dehydrogenase activity
HU175_RS22455	COG0617	tRNA 3'-terminal CCA addition
HU175_RS22480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HU175_RS22510	COG0583	DNA-binding transcription factor activity
HU175_RS22520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HU175_RS22525	COG1473	amidohydrolase
HU175_RS22530	COG1629	transport
HU175_RS22550	COG1725	Transcriptional regulator
HU175_RS22560	COG4952	isomerase
HU175_RS22565	COG3347	Dehydrogenase
HU175_RS22565	COG1028	Short-chain dehydrogenase reductase Sdr
HU175_RS22570	COG4771	TonB-dependent receptor
HU175_RS22590	COG1595	DNA-templated transcription, initiation
HU175_RS22620	COG1690	Belongs to the RtcB family
HU175_RS22635	COG3387	PFAM Glycoside hydrolase 15-related
HU175_RS22655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HU175_RS22670	COG1575	Belongs to the MenA family. Type 1 subfamily
HU175_RS22675	COG0386	Belongs to the glutathione peroxidase family
HU175_RS22685	COG0018	arginyl-trna synthetase
HU175_RS22695	COG4221	oxidoreductase activity
HU175_RS22700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HU175_RS22715	COG3158	transport of potassium into the cell
HU175_RS22720	COG1088	dTDP-glucose 4,6-dehydratase activity
HU175_RS22740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HU175_RS22745	COG2223	nitrite transmembrane transporter activity
HU175_RS22770	COG0673	inositol 2-dehydrogenase activity
HU175_RS22780	COG0673	inositol 2-dehydrogenase activity
HU175_RS22825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HU175_RS22825	COG0131	Imidazoleglycerol-phosphate dehydratase
HU175_RS22835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HU175_RS22845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU175_RS22855	COG0006	proline dipeptidase activity
HU175_RS22885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU175_RS22890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HU175_RS22940	COG1404	Belongs to the peptidase S8 family
HU175_RS22955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HU175_RS22980	COG4115	mRNA cleavage
HU175_RS23020	COG1309	transcriptional regulator
HU175_RS23050	COG4932	domain protein
HU175_RS23050	COG3266	domain, Protein
HU175_RS23050	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HU175_RS23060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HU175_RS23065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HU175_RS23085	COG1556	Lactate utilization protein
HU175_RS23090	COG3275	phosphorelay sensor kinase activity
HU175_RS23095	COG3279	Response regulator of the LytR AlgR family
HU175_RS23110	COG3104	oligopeptide transport
HU175_RS23130	COG0596	Alpha beta hydrolase
HU175_RS23155	COG0719	Fe-S assembly protein
HU175_RS23165	COG1858	cytochrome C peroxidase
HU175_RS23170	COG1283	sodium-dependent phosphate transmembrane transporter activity
HU175_RS23205	COG0556	nucleotide-excision repair
HU175_RS23210	COG2382	esterase
HU175_RS23230	COG4191	Histidine kinase
HU175_RS23235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HU175_RS23245	COG1678	Uncharacterized ACR, COG1678
HU175_RS23255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS23260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU175_RS23270	COG2814	Major facilitator Superfamily
HU175_RS23285	COG2814	Major facilitator Superfamily
HU175_RS23290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HU175_RS23290	COG2755	lipolytic protein G-D-S-L family
HU175_RS23300	COG2096	Adenosyltransferase
HU175_RS23315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HU175_RS23330	COG1492	cobalamin metabolic process
HU175_RS23355	COG1797	cobyrinic acid a,c-diamide synthase activity
HU175_RS23395	COG3275	phosphorelay sensor kinase activity
HU175_RS23415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HU175_RS23420	COG0594	ribonuclease P activity
HU175_RS23425	COG0793	Belongs to the peptidase S41A family
HU175_RS23430	COG1214	PFAM Peptidase M22, glycoprotease
HU175_RS23450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HU175_RS23470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HU175_RS23480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HU175_RS23480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HU175_RS23500	COG4948	Mandelate Racemase Muconate Lactonizing
HU175_RS23505	COG0156	8-amino-7-oxononanoate synthase activity
HU175_RS23535	COG0859	PFAM glycosyl transferase family 9
HU175_RS23540	COG0297	glycogen (starch) synthase activity
HU175_RS23550	COG0110	maltose O-acetyltransferase activity
HU175_RS23570	COG0438	transferase activity, transferring glycosyl groups
HU175_RS23570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HU175_RS23580	COG0110	maltose O-acetyltransferase activity
HU175_RS23595	COG0489	protein tyrosine kinase activity
HU175_RS23625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HU175_RS23630	COG1228	amidohydrolase
HU175_RS23640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HU175_RS23650	COG0148	phosphopyruvate hydratase activity
HU175_RS23660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HU175_RS23665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HU175_RS23670	COG0508	dehydrogenase complex catalyzes the overall conversion of
HU175_RS23680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HU175_RS23710	COG0181	hydroxymethylbilane synthase activity
HU175_RS23720	COG1695	Transcriptional regulator
HU175_RS23740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HU175_RS23745	COG3938	Belongs to the proline racemase family
HU175_RS23750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HU175_RS23755	COG4977	sequence-specific DNA binding
HU175_RS23780	COG3424	synthase
HU175_RS23790	COG0861	Integral membrane protein TerC family
HU175_RS23800	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HU175_RS23800	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HU175_RS23805	COG0505	Belongs to the CarA family
HU175_RS23810	COG0203	ribosomal protein L17
HU175_RS23815	COG0202	RNA polymerase activity
HU175_RS23820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HU175_RS23825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HU175_RS23830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HU175_RS23835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HU175_RS23840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HU175_RS23845	COG0024	Methionine aminopeptidase
HU175_RS23855	COG0200	Binds to the 23S rRNA
HU175_RS23860	COG1841	ribosomal large subunit assembly
HU175_RS23865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HU175_RS23870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HU175_RS23875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HU175_RS23880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HU175_RS23885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HU175_RS23890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HU175_RS23895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HU175_RS23900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HU175_RS23905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HU175_RS23910	COG0255	Belongs to the universal ribosomal protein uL29 family
HU175_RS23915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HU175_RS23920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HU175_RS23925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HU175_RS23930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HU175_RS23935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HU175_RS23940	COG0089	rRNA binding
HU175_RS23945	COG0088	Forms part of the polypeptide exit tunnel
HU175_RS23950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HU175_RS23955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HU175_RS24000	COG2353	YceI-like domain
HU175_RS24015	COG0592	DNA-directed DNA polymerase activity
HU175_RS24030	COG0583	DNA-binding transcription factor activity
HU175_RS24055	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HU175_RS24060	COG1136	(ABC) transporter
HU175_RS24075	COG1872	DUF167
HU175_RS24080	COG0463	Glycosyl transferase, family 2
HU175_RS24110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HU175_RS24115	COG1250	3-hydroxyacyl-CoA dehydrogenase
HU175_RS24115	COG1024	Enoyl-CoA hydratase
HU175_RS24140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HU175_RS24160	COG1271	oxidase subunit
HU175_RS24165	COG1294	oxidase, subunit
HU175_RS24170	COG1515	deoxyribonuclease V activity
HU175_RS24205	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HU175_RS24205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HU175_RS24240	COG0860	N-Acetylmuramoyl-L-alanine amidase
HU175_RS24275	COG0488	(ABC) transporter
HU175_RS24280	COG0586	Pfam SNARE associated Golgi protein
HU175_RS24285	COG1024	Enoyl-CoA hydratase
HU175_RS24285	COG1250	3-hydroxyacyl-CoA dehydrogenase
HU175_RS24305	COG0275	rRNA processing
HU175_RS24310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HU175_RS24330	COG0606	chelatase, subunit chli
HU175_RS24345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HU175_RS24355	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HU175_RS24365	COG4206	TonB-dependent receptor
HU175_RS24365	COG1629	transport
HU175_RS24370	COG1252	NADH dehydrogenase
HU175_RS24385	COG4946	Tricorn protease homolog
HU175_RS24385	COG1506	peptidase
HU175_RS24385	COG0823	Involved in the tonB-independent uptake of proteins
HU175_RS24385	COG4946	Tricorn protease homolog
HU175_RS24385	COG1506	peptidase
HU175_RS24385	COG0823	Involved in the tonB-independent uptake of proteins
HU175_RS24435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HU175_RS24435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HU175_RS24440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HU175_RS24440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HU175_RS24445	COG2814	Major facilitator Superfamily
HU175_RS24465	COG0167	dihydroorotate dehydrogenase activity
HU175_RS24470	COG1674	ftsk spoiiie
HU175_RS24480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HU175_RS24490	COG0460	homoserine dehydrogenase
HU175_RS24490	COG0527	aspartate kinase activity
HU175_RS24495	COG0628	permease
HU175_RS24505	COG0346	lactoylglutathione lyase activity
HU175_RS24585	COG3750	Belongs to the UPF0335 family
HU175_RS24600	COG0629	single-stranded DNA binding