locus-tag	class	description
HNV11_RS00010	COG0571	ribonuclease III activity
HNV11_RS00015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HNV11_RS00020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HNV11_RS00025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HNV11_RS00030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HNV11_RS00045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HNV11_RS00075	COG0713	ATP synthesis coupled electron transport
HNV11_RS00085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNV11_RS00090	COG1007	ATP synthesis coupled electron transport
HNV11_RS00125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HNV11_RS00150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HNV11_RS00155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HNV11_RS00170	COG1595	DNA-templated transcription, initiation
HNV11_RS00185	COG0151	Belongs to the GarS family
HNV11_RS00190	COG1774	PSP1 C-terminal conserved region
HNV11_RS00210	COG0671	phosphoesterase, PA-phosphatase related
HNV11_RS00220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HNV11_RS00220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNV11_RS00230	COG3590	peptidase
HNV11_RS00275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HNV11_RS00280	COG0081	regulation of translation
HNV11_RS00285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HNV11_RS00290	COG0222	ribosome binding
HNV11_RS00295	COG0085	RNA polymerase activity
HNV11_RS00300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HNV11_RS00320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HNV11_RS00335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HNV11_RS00340	COG0051	transcription antitermination factor activity, RNA binding
HNV11_RS00345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HNV11_RS00350	COG0088	Forms part of the polypeptide exit tunnel
HNV11_RS00355	COG0089	rRNA binding
HNV11_RS00360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HNV11_RS00365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HNV11_RS00370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HNV11_RS00375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HNV11_RS00380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HNV11_RS00385	COG0255	Belongs to the universal ribosomal protein uL29 family
HNV11_RS00390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HNV11_RS00395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HNV11_RS00400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HNV11_RS00405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HNV11_RS00410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HNV11_RS00415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HNV11_RS00420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HNV11_RS00425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HNV11_RS00430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HNV11_RS00435	COG1841	ribosomal large subunit assembly
HNV11_RS00440	COG0200	Binds to the 23S rRNA
HNV11_RS00445	COG0201	protein transport
HNV11_RS00450	COG0024	Methionine aminopeptidase
HNV11_RS00455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HNV11_RS00460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HNV11_RS00465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HNV11_RS00470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HNV11_RS00475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HNV11_RS00480	COG0202	RNA polymerase activity
HNV11_RS00485	COG0203	ribosomal protein L17
HNV11_RS00490	COG0505	Belongs to the CarA family
HNV11_RS00500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HNV11_RS00500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HNV11_RS00510	COG0463	Glycosyl transferase, family 2
HNV11_RS00515	COG3424	synthase
HNV11_RS00555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HNV11_RS00575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HNV11_RS00605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HNV11_RS00610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HNV11_RS00620	COG0545	Peptidyl-prolyl cis-trans isomerase
HNV11_RS00630	COG0105	UTP biosynthetic process
HNV11_RS00645	COG1595	DNA-templated transcription, initiation
HNV11_RS00655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HNV11_RS00665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HNV11_RS00675	COG1674	ftsk spoiiie
HNV11_RS00680	COG0167	dihydroorotate dehydrogenase activity
HNV11_RS00695	COG0318	PFAM AMP-dependent synthetase and ligase
HNV11_RS00735	COG0463	Glycosyl transferase, family 2
HNV11_RS00740	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HNV11_RS00775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HNV11_RS00780	COG2091	lysine biosynthetic process via aminoadipic acid
HNV11_RS00795	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS00830	COG0494	nUDIX hydrolase
HNV11_RS00835	COG0823	Involved in the tonB-independent uptake of proteins
HNV11_RS00835	COG4946	Tricorn protease homolog
HNV11_RS00835	COG1506	peptidase
HNV11_RS00845	COG3591	Belongs to the peptidase S1B family
HNV11_RS00850	COG1252	NADH dehydrogenase
HNV11_RS00855	COG4206	TonB-dependent receptor
HNV11_RS00855	COG1629	transport
HNV11_RS00865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HNV11_RS00875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HNV11_RS00895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HNV11_RS00900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HNV11_RS00905	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNV11_RS00920	COG4771	TonB-dependent receptor
HNV11_RS00940	COG1011	Hydrolase
HNV11_RS00955	COG2207	Transcriptional regulator
HNV11_RS00955	COG0662	Cupin 2, conserved barrel domain protein
HNV11_RS00965	COG0673	inositol 2-dehydrogenase activity
HNV11_RS00980	COG2814	Major facilitator Superfamily
HNV11_RS00985	COG0673	inositol 2-dehydrogenase activity
HNV11_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS00995	COG1902	pentaerythritol trinitrate reductase activity
HNV11_RS01040	COG0606	chelatase, subunit chli
HNV11_RS01045	COG0275	rRNA processing
HNV11_RS01060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HNV11_RS01060	COG1024	Enoyl-CoA hydratase
HNV11_RS01065	COG0586	Pfam SNARE associated Golgi protein
HNV11_RS01070	COG0488	(ABC) transporter
HNV11_RS01075	COG0515	serine threonine protein kinase
HNV11_RS01075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HNV11_RS01085	COG0436	Aminotransferase
HNV11_RS01100	COG0564	pseudouridine synthase activity
HNV11_RS01105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HNV11_RS01125	COG1764	response to oxidative stress
HNV11_RS01135	COG0564	pseudouridine synthase activity
HNV11_RS01140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HNV11_RS01150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HNV11_RS01185	COG1215	transferase activity, transferring glycosyl groups
HNV11_RS01195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HNV11_RS01210	COG3940	Belongs to the glycosyl hydrolase 43 family
HNV11_RS01220	COG0657	acetylesterase activity
HNV11_RS01275	COG0768	penicillin binding
HNV11_RS01280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HNV11_RS01285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HNV11_RS01290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HNV11_RS01295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HNV11_RS01300	COG0052	Belongs to the universal ribosomal protein uS2 family
HNV11_RS01305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HNV11_RS01330	COG1970	mechanosensitive ion channel activity
HNV11_RS01335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HNV11_RS01340	COG0772	Belongs to the SEDS family
HNV11_RS01345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HNV11_RS01350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HNV11_RS01365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HNV11_RS01375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HNV11_RS01380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HNV11_RS01395	COG2115	Belongs to the xylose isomerase family
HNV11_RS01410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HNV11_RS01410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HNV11_RS01425	COG1073	alpha beta
HNV11_RS01430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HNV11_RS01435	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS01440	COG1132	(ABC) transporter
HNV11_RS01470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HNV11_RS01485	COG0656	L-ascorbic acid biosynthetic process
HNV11_RS01530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HNV11_RS01535	COG1216	Glycosyl transferase, family 2
HNV11_RS01540	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS01670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HNV11_RS01710	COG2353	YceI-like domain
HNV11_RS01715	COG0463	Glycosyl transferase, family 2
HNV11_RS01735	COG1086	Polysaccharide biosynthesis protein
HNV11_RS01770	COG0351	phosphomethylpyrimidine kinase
HNV11_RS01770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HNV11_RS01770	COG0352	thiamine-phosphate diphosphorylase activity
HNV11_RS01775	COG0351	phosphomethylpyrimidine kinase
HNV11_RS01785	COG0352	thiamine-phosphate diphosphorylase activity
HNV11_RS01790	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HNV11_RS01795	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HNV11_RS01795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HNV11_RS01800	COG0251	oxidation-reduction process
HNV11_RS01815	COG2205	protein histidine kinase activity
HNV11_RS01850	COG1515	deoxyribonuclease V activity
HNV11_RS01860	COG1294	oxidase, subunit
HNV11_RS01865	COG1271	oxidase subunit
HNV11_RS01880	COG4251	negative regulation of phosphorylation
HNV11_RS01895	COG4251	negative regulation of phosphorylation
HNV11_RS01900	COG3250	beta-galactosidase activity
HNV11_RS01910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNV11_RS01950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HNV11_RS01965	COG0183	Belongs to the thiolase family
HNV11_RS01970	COG1250	3-hydroxyacyl-CoA dehydrogenase
HNV11_RS01970	COG1024	Enoyl-CoA hydratase
HNV11_RS01975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HNV11_RS02005	COG0463	Glycosyl transferase, family 2
HNV11_RS02010	COG1872	DUF167
HNV11_RS02025	COG1136	(ABC) transporter
HNV11_RS02030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HNV11_RS02050	COG0583	DNA-binding transcription factor activity
HNV11_RS02055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HNV11_RS02060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HNV11_RS02065	COG0860	N-Acetylmuramoyl-L-alanine amidase
HNV11_RS02080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HNV11_RS02080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HNV11_RS02105	COG1278	Cold shock
HNV11_RS02110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HNV11_RS02135	COG1214	PFAM Peptidase M22, glycoprotease
HNV11_RS02140	COG0793	Belongs to the peptidase S41A family
HNV11_RS02145	COG0594	ribonuclease P activity
HNV11_RS02150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HNV11_RS02180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HNV11_RS02180	COG2755	lipolytic protein G-D-S-L family
HNV11_RS02185	COG2814	Major facilitator Superfamily
HNV11_RS02195	COG2814	Major facilitator Superfamily
HNV11_RS02200	COG2814	Major facilitator Superfamily
HNV11_RS02220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNV11_RS02230	COG1678	Uncharacterized ACR, COG1678
HNV11_RS02240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HNV11_RS02280	COG2204	response regulator
HNV11_RS02285	COG2382	esterase
HNV11_RS02295	COG0556	nucleotide-excision repair
HNV11_RS02300	COG1473	amidohydrolase
HNV11_RS02305	COG1505	serine-type exopeptidase activity
HNV11_RS02310	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HNV11_RS02315	COG4221	oxidoreductase activity
HNV11_RS02325	COG0083	homoserine kinase activity
HNV11_RS02335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HNV11_RS02350	COG0653	protein targeting
HNV11_RS02370	COG2244	polysaccharide biosynthetic process
HNV11_RS02435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HNV11_RS02445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HNV11_RS02450	COG2755	lipolytic protein G-D-S-L family
HNV11_RS02450	COG0657	acetylesterase activity
HNV11_RS02455	COG2353	YceI-like domain
HNV11_RS02460	COG3279	Response regulator of the LytR AlgR family
HNV11_RS02465	COG3275	phosphorelay sensor kinase activity
HNV11_RS02505	COG0784	Response regulator, receiver
HNV11_RS02505	COG2205	protein histidine kinase activity
HNV11_RS02525	COG0022	dehydrogenase e1 component
HNV11_RS02555	COG0415	Belongs to the DNA photolyase family
HNV11_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS02600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HNV11_RS02605	COG2912	Transglutaminase-like superfamily
HNV11_RS02625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HNV11_RS02640	COG1162	GTPase activity
HNV11_RS02680	COG0181	hydroxymethylbilane synthase activity
HNV11_RS02705	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS02710	COG2137	regulation of response to DNA damage stimulus
HNV11_RS02715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HNV11_RS02720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HNV11_RS02720	COG0473	3-isopropylmalate dehydrogenase activity
HNV11_RS02725	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS02760	COG1090	epimerase
HNV11_RS02765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HNV11_RS02770	COG0583	DNA-binding transcription factor activity
HNV11_RS02780	COG0189	ligase activity
HNV11_RS02785	COG0189	ligase activity
HNV11_RS02785	COG4067	protein conserved in archaea
HNV11_RS02790	COG0470	DNA polymerase III
HNV11_RS02795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HNV11_RS02820	COG0492	ferredoxin-NADP+ reductase activity
HNV11_RS02830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HNV11_RS02835	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HNV11_RS02865	COG4206	TonB-dependent receptor
HNV11_RS02865	COG1629	transport
HNV11_RS02900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HNV11_RS02905	COG0154	amidase activity
HNV11_RS02910	COG1388	LysM domain
HNV11_RS02910	COG1705	Flagellar rod assembly protein muramidase FlgJ
HNV11_RS02925	COG0667	Aldo Keto reductase
HNV11_RS02930	COG0509	glycine decarboxylation via glycine cleavage system
HNV11_RS02935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HNV11_RS02960	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HNV11_RS02985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNV11_RS02985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNV11_RS02995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNV11_RS02995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNV11_RS03000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HNV11_RS03030	COG0561	phosphatase activity
HNV11_RS03035	COG4771	TonB-dependent receptor
HNV11_RS03045	COG2197	response regulator
HNV11_RS03060	COG3227	Zinc metalloprotease (Elastase)
HNV11_RS03085	COG0673	inositol 2-dehydrogenase activity
HNV11_RS03090	COG4585	Histidine kinase
HNV11_RS03100	COG1012	belongs to the aldehyde dehydrogenase family
HNV11_RS03115	COG2814	Major facilitator Superfamily
HNV11_RS03130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HNV11_RS03135	COG2045	Belongs to the ComB family
HNV11_RS03140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HNV11_RS03145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HNV11_RS03150	COG1187	pseudouridine synthase activity
HNV11_RS03155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HNV11_RS03160	COG0793	Belongs to the peptidase S41A family
HNV11_RS03175	COG0719	Fe-S assembly protein
HNV11_RS03200	COG2267	carboxylic ester hydrolase activity
HNV11_RS03220	COG2169	Transcriptional regulator
HNV11_RS03225	COG0596	Alpha beta hydrolase
HNV11_RS03230	COG2205	protein histidine kinase activity
HNV11_RS03235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HNV11_RS03245	COG4221	oxidoreductase activity
HNV11_RS03285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HNV11_RS03300	COG1575	Belongs to the MenA family. Type 1 subfamily
HNV11_RS03305	COG0386	Belongs to the glutathione peroxidase family
HNV11_RS03315	COG0018	arginyl-trna synthetase
HNV11_RS03335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HNV11_RS03340	COG4251	negative regulation of phosphorylation
HNV11_RS03400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HNV11_RS03410	COG0745	RESPONSE REGULATOR receiver
HNV11_RS03410	COG2205	protein histidine kinase activity
HNV11_RS03410	COG3292	Two component regulator propeller
HNV11_RS03425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HNV11_RS03445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNV11_RS03455	COG2197	response regulator
HNV11_RS03460	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNV11_RS03485	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS03505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HNV11_RS03515	COG0489	protein tyrosine kinase activity
HNV11_RS03535	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS03565	COG0254	rRNA binding
HNV11_RS03570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HNV11_RS03570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HNV11_RS03600	COG0277	FAD linked oxidase domain protein
HNV11_RS03610	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HNV11_RS03615	COG4251	negative regulation of phosphorylation
HNV11_RS03645	COG1595	DNA-templated transcription, initiation
HNV11_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS03720	COG0673	inositol 2-dehydrogenase activity
HNV11_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS03735	COG4821	SIS domain
HNV11_RS03750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HNV11_RS03755	COG0316	Belongs to the HesB IscA family
HNV11_RS03760	COG0346	lactoylglutathione lyase activity
HNV11_RS03770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNV11_RS03775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HNV11_RS03780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HNV11_RS03790	COG0148	phosphopyruvate hydratase activity
HNV11_RS03805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNV11_RS03820	COG0248	Ppx GppA phosphatase
HNV11_RS03825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HNV11_RS03830	COG4974	Belongs to the 'phage' integrase family
HNV11_RS03865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HNV11_RS03885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HNV11_RS03890	COG2873	o-acetylhomoserine
HNV11_RS03925	COG1619	proteins homologs of microcin C7 resistance protein MccF
HNV11_RS03930	COG1363	Peptidase, m42
HNV11_RS03940	COG0740	serine-type endopeptidase activity
HNV11_RS03950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HNV11_RS03975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HNV11_RS03980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HNV11_RS03985	COG0791	NLP P60 protein
HNV11_RS04000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HNV11_RS04030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HNV11_RS04035	COG0667	Aldo Keto reductase
HNV11_RS04040	COG2308	Evidence 4 Homologs of previously reported genes of
HNV11_RS04045	COG1215	transferase activity, transferring glycosyl groups
HNV11_RS04055	COG0217	transcriptional regulatory protein
HNV11_RS04060	COG0019	diaminopimelate decarboxylase activity
HNV11_RS04070	COG0363	glucosamine-6-phosphate deaminase activity
HNV11_RS04075	COG2252	PERMEase
HNV11_RS04085	COG2151	metal-sulfur cluster biosynthetic enzyme
HNV11_RS04095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HNV11_RS04100	COG0719	Fe-S assembly protein
HNV11_RS04105	COG0396	ATPase activity
HNV11_RS04110	COG2235	arginine
HNV11_RS04170	COG4771	TonB-dependent receptor
HNV11_RS04185	COG1629	transport
HNV11_RS04185	COG4206	TonB-dependent receptor
HNV11_RS04195	COG1629	transport
HNV11_RS04200	COG1473	amidohydrolase
HNV11_RS04205	COG0300	oxidoreductase activity
HNV11_RS04215	COG0673	inositol 2-dehydrogenase activity
HNV11_RS04235	COG4771	TonB-dependent receptor
HNV11_RS04255	COG1472	Belongs to the glycosyl hydrolase 3 family
HNV11_RS04270	COG0700	Nucleoside recognition
HNV11_RS04285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HNV11_RS04290	COG0297	glycogen (starch) synthase activity
HNV11_RS04300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HNV11_RS04340	COG0154	amidase activity
HNV11_RS04380	COG1404	Belongs to the peptidase S8 family
HNV11_RS04390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HNV11_RS04400	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HNV11_RS04410	COG2721	sulfolactate sulfo-lyase activity
HNV11_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS04420	COG2205	protein histidine kinase activity
HNV11_RS04425	COG0745	RESPONSE REGULATOR receiver
HNV11_RS04440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNV11_RS04445	COG3158	transport of potassium into the cell
HNV11_RS04460	COG4134	Bacterial extracellular solute-binding protein
HNV11_RS04500	COG1914	H( )-stimulated, divalent metal cation uptake system
HNV11_RS04530	COG0463	Glycosyl transferase, family 2
HNV11_RS04535	COG0463	Glycosyl transferase, family 2
HNV11_RS04545	COG1696	Membrane protein involved in D-alanine export
HNV11_RS04550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNV11_RS04570	COG0738	Major facilitator superfamily
HNV11_RS04575	COG3254	rhamnose metabolic process
HNV11_RS04595	COG0517	IMP dehydrogenase activity
HNV11_RS04595	COG1125	glycine betaine transport
HNV11_RS04600	COG1174	glycine betaine transport
HNV11_RS04605	COG2094	Belongs to the DNA glycosylase MPG family
HNV11_RS04630	COG1561	YicC-like family, N-terminal region
HNV11_RS04635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HNV11_RS04640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HNV11_RS04655	COG0393	Putative heavy-metal-binding
HNV11_RS04695	COG0540	Belongs to the ATCase OTCase family
HNV11_RS04710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HNV11_RS04715	COG1629	transport
HNV11_RS04715	COG4206	TonB-dependent receptor
HNV11_RS04720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HNV11_RS04725	COG0424	maF-like protein
HNV11_RS04730	COG0456	acetyltransferase
HNV11_RS04745	COG2353	YceI-like domain
HNV11_RS04755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HNV11_RS04760	COG4974	Belongs to the 'phage' integrase family
HNV11_RS04820	COG1032	radical SAM domain protein
HNV11_RS04825	COG0071	Belongs to the small heat shock protein (HSP20) family
HNV11_RS04830	COG0135	phosphoribosylanthranilate isomerase activity
HNV11_RS04840	COG0673	inositol 2-dehydrogenase activity
HNV11_RS04870	COG0165	Argininosuccinate lyase
HNV11_RS04925	COG0246	Mannitol dehydrogenase
HNV11_RS04930	COG0800	Aldolase
HNV11_RS04940	COG2271	Major facilitator Superfamily
HNV11_RS04945	COG0596	Alpha beta hydrolase
HNV11_RS04950	COG0439	Biotin carboxylase
HNV11_RS04955	COG0156	8-amino-7-oxononanoate synthase activity
HNV11_RS04970	COG2755	lipolytic protein G-D-S-L family
HNV11_RS04970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HNV11_RS04990	COG1597	lipid kinase activity
HNV11_RS04995	COG0137	argininosuccinate synthase activity
HNV11_RS05005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HNV11_RS05020	COG2390	Transcriptional regulator
HNV11_RS05020	COG4584	PFAM Integrase catalytic
HNV11_RS05025	COG0673	inositol 2-dehydrogenase activity
HNV11_RS05030	COG0501	Belongs to the peptidase M48B family
HNV11_RS05045	COG0366	Alpha amylase catalytic
HNV11_RS05050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HNV11_RS05060	COG1136	(ABC) transporter
HNV11_RS05065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HNV11_RS05080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HNV11_RS05090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HNV11_RS05110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HNV11_RS05125	COG5180	pathogenesis
HNV11_RS05125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HNV11_RS05130	COG0195	Participates in both transcription termination and antitermination
HNV11_RS05135	COG0779	Required for maturation of 30S ribosomal subunits
HNV11_RS05145	COG0314	molybdopterin synthase activity
HNV11_RS05160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HNV11_RS05175	COG2942	2-epimerase
HNV11_RS05185	COG0702	epimerase
HNV11_RS05190	COG4771	TonB-dependent receptor
HNV11_RS05195	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HNV11_RS05205	COG4251	negative regulation of phosphorylation
HNV11_RS05225	COG1418	mRNA catabolic process
HNV11_RS05260	COG0307	riboflavin synthase, alpha
HNV11_RS05265	COG0515	serine threonine protein kinase
HNV11_RS05265	COG2815	serine threonine protein kinase
HNV11_RS05275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HNV11_RS05275	COG0425	Belongs to the sulfur carrier protein TusA family
HNV11_RS05280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HNV11_RS05285	COG1733	regulation of RNA biosynthetic process
HNV11_RS05305	COG1652	LysM domain
HNV11_RS05335	COG1482	cell wall glycoprotein biosynthetic process
HNV11_RS05350	COG1070	Carbohydrate kinase
HNV11_RS05355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HNV11_RS05360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HNV11_RS05365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HNV11_RS05405	COG0284	orotidine-5'-phosphate decarboxylase activity
HNV11_RS05440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HNV11_RS05440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HNV11_RS05450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HNV11_RS05470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HNV11_RS05475	COG1473	amidohydrolase
HNV11_RS05505	COG1104	cysteine desulfurase activity
HNV11_RS05520	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS05540	COG4251	negative regulation of phosphorylation
HNV11_RS05570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HNV11_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS05590	COG3920	Histidine kinase
HNV11_RS05600	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HNV11_RS05610	COG2323	membrane
HNV11_RS05625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HNV11_RS05645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HNV11_RS05665	COG0322	excinuclease ABC activity
HNV11_RS05685	COG0356	it plays a direct role in the translocation of protons across the membrane
HNV11_RS05690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HNV11_RS05695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HNV11_RS05700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HNV11_RS05720	COG0702	epimerase
HNV11_RS05725	COG3386	PFAM SMP-30 Gluconolaconase
HNV11_RS05735	COG0772	Belongs to the SEDS family
HNV11_RS05755	COG0193	aminoacyl-tRNA hydrolase activity
HNV11_RS05760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HNV11_RS05770	COG1597	lipid kinase activity
HNV11_RS05770	COG1803	Methylglyoxal synthase
HNV11_RS05785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HNV11_RS05795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HNV11_RS05805	COG2226	methyltransferase
HNV11_RS05810	COG1629	transport
HNV11_RS05840	COG0126	phosphoglycerate kinase activity
HNV11_RS05855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HNV11_RS05865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HNV11_RS05870	COG3217	Mosc domain protein beta barrel domain protein
HNV11_RS05870	COG0633	Ferredoxin
HNV11_RS05880	COG0346	lactoylglutathione lyase activity
HNV11_RS05915	COG4771	TonB-dependent receptor
HNV11_RS05920	COG3279	Response regulator of the LytR AlgR family
HNV11_RS05925	COG2972	Histidine kinase
HNV11_RS05935	COG2353	YceI-like domain
HNV11_RS05975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNV11_RS05985	COG1595	DNA-templated transcription, initiation
HNV11_RS05990	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNV11_RS05995	COG1012	belongs to the aldehyde dehydrogenase family
HNV11_RS06015	COG1388	LysM domain
HNV11_RS06015	COG3858	chitin binding
HNV11_RS06020	COG2204	response regulator
HNV11_RS06025	COG2884	Cell division ATP-binding protein ftsE
HNV11_RS06030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HNV11_RS06035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HNV11_RS06060	COG0316	Belongs to the HesB IscA family
HNV11_RS06065	COG5000	phosphorelay sensor kinase activity
HNV11_RS06080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HNV11_RS06090	COG1183	phosphatidylcholine synthase activity
HNV11_RS06095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNV11_RS06100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HNV11_RS06105	COG2267	carboxylic ester hydrolase activity
HNV11_RS06145	COG0799	negative regulation of ribosome biogenesis
HNV11_RS06150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HNV11_RS06160	COG0318	PFAM AMP-dependent synthetase and ligase
HNV11_RS06165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HNV11_RS06170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HNV11_RS06175	COG0187	DNA topoisomerase II activity
HNV11_RS06185	COG0686	Belongs to the AlaDH PNT family
HNV11_RS06190	COG0802	atpase or kinase
HNV11_RS06195	COG0673	inositol 2-dehydrogenase activity
HNV11_RS06205	COG1629	transport
HNV11_RS06210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HNV11_RS06220	COG1181	Belongs to the D-alanine--D-alanine ligase family
HNV11_RS06225	COG0316	Belongs to the HesB IscA family
HNV11_RS06225	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HNV11_RS06230	COG0489	protein tyrosine kinase activity
HNV11_RS06245	COG0359	binds to the 23S rRNA
HNV11_RS06250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HNV11_RS06255	COG0360	Binds together with S18 to 16S ribosomal RNA
HNV11_RS06265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HNV11_RS06270	COG2363	Small membrane protein
HNV11_RS06290	COG5002	protein histidine kinase activity
HNV11_RS06310	COG1404	Belongs to the peptidase S8 family
HNV11_RS06340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HNV11_RS06350	COG2226	methyltransferase
HNV11_RS06365	COG2205	protein histidine kinase activity
HNV11_RS06370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNV11_RS06395	COG3279	Response regulator of the LytR AlgR family
HNV11_RS06410	COG0784	Response regulator, receiver
HNV11_RS06415	COG3852	Histidine kinase
HNV11_RS06445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNV11_RS06450	COG2610	gluconate transmembrane transporter activity
HNV11_RS06475	COG2885	chlorophyll binding
HNV11_RS06490	COG5002	protein histidine kinase activity
HNV11_RS06500	COG1506	peptidase
HNV11_RS06500	COG0823	Involved in the tonB-independent uptake of proteins
HNV11_RS06505	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HNV11_RS06520	COG1169	isochorismate synthase
HNV11_RS06530	COG0406	alpha-ribazole phosphatase activity
HNV11_RS06535	COG3275	phosphorelay sensor kinase activity
HNV11_RS06540	COG3279	Response regulator of the LytR AlgR family
HNV11_RS06560	COG0686	Belongs to the AlaDH PNT family
HNV11_RS06565	COG1522	sequence-specific DNA binding
HNV11_RS06570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNV11_RS06590	COG1192	Involved in chromosome partitioning
HNV11_RS06605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HNV11_RS06615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HNV11_RS06680	COG0191	fructose-bisphosphate aldolase activity
HNV11_RS06710	COG3547	Transposase (IS116 IS110 IS902 family)
HNV11_RS06740	COG0300	oxidoreductase activity
HNV11_RS06755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNV11_RS06765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNV11_RS06815	COG0427	acetyl-CoA hydrolase
HNV11_RS06820	COG2723	6-phospho-beta-galactosidase activity
HNV11_RS06945	COG1222	aaa ATPase
HNV11_RS06965	COG3275	phosphorelay sensor kinase activity
HNV11_RS06995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HNV11_RS07020	COG3119	arylsulfatase activity
HNV11_RS07020	COG3408	Glycogen debranching enzyme
HNV11_RS07025	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HNV11_RS07030	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS07035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNV11_RS07035	COG1703	isobutyryl-CoA mutase activity
HNV11_RS07035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HNV11_RS07045	COG0577	efflux transmembrane transporter activity
HNV11_RS07050	COG3876	Protein conserved in bacteria
HNV11_RS07060	COG0519	Catalyzes the synthesis of GMP from XMP
HNV11_RS07060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HNV11_RS07080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HNV11_RS07110	COG0823	Involved in the tonB-independent uptake of proteins
HNV11_RS07110	COG1506	peptidase
HNV11_RS07125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNV11_RS07125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HNV11_RS07140	COG0697	spore germination
HNV11_RS07160	COG3254	rhamnose metabolic process
HNV11_RS07170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HNV11_RS07195	COG2072	flavoprotein involved in K transport
HNV11_RS07210	COG2267	carboxylic ester hydrolase activity
HNV11_RS07220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HNV11_RS07255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HNV11_RS07255	COG0617	tRNA 3'-terminal CCA addition
HNV11_RS07255	COG0517	IMP dehydrogenase activity
HNV11_RS07295	COG2234	aminopeptidase activity
HNV11_RS07295	COG4935	Belongs to the peptidase S8 family
HNV11_RS07300	COG2350	Protein conserved in bacteria
HNV11_RS07305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNV11_RS07320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HNV11_RS07325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HNV11_RS07345	COG1705	Flagellar rod assembly protein muramidase FlgJ
HNV11_RS07345	COG1388	LysM domain
HNV11_RS07355	COG1490	D-aminoacyl-tRNA deacylase activity
HNV11_RS07360	COG0784	Response regulator, receiver
HNV11_RS07365	COG4251	negative regulation of phosphorylation
HNV11_RS07390	COG3550	peptidyl-serine autophosphorylation
HNV11_RS07440	COG1024	Enoyl-CoA hydratase
HNV11_RS07455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HNV11_RS07470	COG0546	phosphoglycolate phosphatase activity
HNV11_RS07480	COG4771	TonB-dependent receptor
HNV11_RS07505	COG4771	TonB-dependent receptor
HNV11_RS07535	COG4993	Dehydrogenase
HNV11_RS07540	COG1216	Glycosyl transferase, family 2
HNV11_RS07575	COG2133	pyrroloquinoline quinone binding
HNV11_RS07590	COG1063	alcohol dehydrogenase
HNV11_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS07605	COG4771	TonB-dependent receptor
HNV11_RS07635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HNV11_RS07645	COG1082	Xylose isomerase domain protein TIM barrel
HNV11_RS07670	COG0702	epimerase
HNV11_RS07675	COG4771	TonB-dependent receptor
HNV11_RS07700	COG1879	ABC-type sugar transport system periplasmic component
HNV11_RS07705	COG1172	Belongs to the binding-protein-dependent transport system permease family
HNV11_RS07710	COG1129	ABC transporter
HNV11_RS07715	COG0673	inositol 2-dehydrogenase activity
HNV11_RS07745	COG0702	epimerase
HNV11_RS07750	COG4771	TonB-dependent receptor
HNV11_RS07755	COG3347	Dehydrogenase
HNV11_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS07770	COG0300	oxidoreductase activity
HNV11_RS07790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HNV11_RS07795	COG0017	Asparaginyl-tRNA synthetase
HNV11_RS07810	COG0346	lactoylglutathione lyase activity
HNV11_RS07825	COG4974	Belongs to the 'phage' integrase family
HNV11_RS07830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HNV11_RS07840	COG2095	MarC family integral membrane protein
HNV11_RS07850	COG2195	Cleaves the N-terminal amino acid of tripeptides
HNV11_RS07855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNV11_RS07860	COG0328	RNA-DNA hybrid ribonuclease activity
HNV11_RS07860	COG3341	Caulimovirus viroplasmin
HNV11_RS07865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HNV11_RS07870	COG0463	Glycosyl transferase, family 2
HNV11_RS07875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HNV11_RS07880	COG0616	signal peptide processing
HNV11_RS07885	COG2207	Transcriptional regulator
HNV11_RS07895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HNV11_RS07915	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNV11_RS07935	COG1266	CAAX protease self-immunity
HNV11_RS07940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HNV11_RS07950	COG5016	pyruvate
HNV11_RS07950	COG0511	ligase activity, forming carbon-carbon bonds
HNV11_RS07960	COG0528	UMP kinase activity
HNV11_RS07965	COG0233	cytoplasmic translational termination
HNV11_RS07985	COG4303	Ethanolamine ammonia lyase large subunit
HNV11_RS07990	COG4302	ethanolamine ammonia-lyase activity
HNV11_RS07995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HNV11_RS07995	COG0758	DNA mediated transformation
HNV11_RS08005	COG1858	cytochrome C peroxidase
HNV11_RS08030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HNV11_RS08035	COG0745	RESPONSE REGULATOR receiver
HNV11_RS08040	COG0488	(ABC) transporter
HNV11_RS08050	COG2345	Transcriptional regulator
HNV11_RS08065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HNV11_RS08085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HNV11_RS08090	COG4251	negative regulation of phosphorylation
HNV11_RS08095	COG1253	flavin adenine dinucleotide binding
HNV11_RS08170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HNV11_RS08170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HNV11_RS08175	COG0335	large ribosomal subunit rRNA binding
HNV11_RS08180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HNV11_RS08185	COG3781	membrane
HNV11_RS08195	COG0326	Molecular chaperone. Has ATPase activity
HNV11_RS08210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HNV11_RS08215	COG0517	IMP dehydrogenase activity
HNV11_RS08215	COG0516	GMP reductase activity
HNV11_RS08230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HNV11_RS08235	COG2816	NAD+ diphosphatase activity
HNV11_RS08240	COG1253	flavin adenine dinucleotide binding
HNV11_RS08250	COG0303	'Molybdopterin
HNV11_RS08255	COG0746	molybdenum cofactor guanylyltransferase activity
HNV11_RS08255	COG0315	cyclic pyranopterin monophosphate synthase activity
HNV11_RS08260	COG0315	cyclic pyranopterin monophosphate synthase activity
HNV11_RS08260	COG0746	molybdenum cofactor guanylyltransferase activity
HNV11_RS08275	COG0590	tRNA wobble adenosine to inosine editing
HNV11_RS08280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HNV11_RS08290	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HNV11_RS08310	COG1695	Transcriptional regulator
HNV11_RS08325	COG1760	l-serine dehydratase
HNV11_RS08335	COG2885	chlorophyll binding
HNV11_RS08350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HNV11_RS08355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HNV11_RS08360	COG0640	Transcriptional regulator
HNV11_RS08365	COG5658	integral membrane protein
HNV11_RS08410	COG3118	belongs to the thioredoxin family
HNV11_RS08420	COG0784	Response regulator, receiver
HNV11_RS08445	COG0408	coproporphyrinogen oxidase activity
HNV11_RS08450	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS08455	COG1663	tetraacyldisaccharide 4'-kinase activity
HNV11_RS08480	COG0481	GTPase activity
HNV11_RS08485	COG1522	sequence-specific DNA binding
HNV11_RS08500	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HNV11_RS08505	COG4251	negative regulation of phosphorylation
HNV11_RS08510	COG0784	Response regulator, receiver
HNV11_RS08515	COG2027	D-alanyl-D-alanine carboxypeptidase
HNV11_RS08520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HNV11_RS08525	COG0825	malonyl-CoA metabolic process
HNV11_RS08555	COG3275	phosphorelay sensor kinase activity
HNV11_RS08560	COG3275	phosphorelay sensor kinase activity
HNV11_RS08565	COG3279	Response regulator of the LytR AlgR family
HNV11_RS08575	COG0006	proline dipeptidase activity
HNV11_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS08605	COG0673	inositol 2-dehydrogenase activity
HNV11_RS08610	COG3661	Belongs to the glycosyl hydrolase 67 family
HNV11_RS08615	COG1312	Catalyzes the dehydration of D-mannonate
HNV11_RS08625	COG2271	Major facilitator Superfamily
HNV11_RS08630	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS08640	COG0667	Aldo Keto reductase
HNV11_RS08655	COG2321	neutral zinc metallopeptidase
HNV11_RS08680	COG3279	Response regulator of the LytR AlgR family
HNV11_RS08705	COG4654	Cytochrome c, class I
HNV11_RS08725	COG2382	esterase
HNV11_RS08725	COG3693	PFAM glycoside hydrolase, family 10
HNV11_RS08735	COG2755	lipolytic protein G-D-S-L family
HNV11_RS08735	COG0657	acetylesterase activity
HNV11_RS08745	COG0583	DNA-binding transcription factor activity
HNV11_RS08770	COG0738	Major facilitator superfamily
HNV11_RS08800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HNV11_RS08820	COG3292	Two component regulator propeller
HNV11_RS08820	COG0745	RESPONSE REGULATOR receiver
HNV11_RS08820	COG2205	protein histidine kinase activity
HNV11_RS08855	COG0456	acetyltransferase
HNV11_RS08865	COG0542	response to heat
HNV11_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS08920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNV11_RS08925	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS08930	COG2207	Transcriptional regulator
HNV11_RS08945	COG0366	Alpha amylase catalytic
HNV11_RS08980	COG0243	molybdopterin cofactor binding
HNV11_RS09005	COG3387	PFAM Glycoside hydrolase 15-related
HNV11_RS09010	COG2272	Belongs to the type-B carboxylesterase lipase family
HNV11_RS09035	COG0259	pyridoxamine-phosphate oxidase activity
HNV11_RS09050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HNV11_RS09085	COG0753	catalase activity
HNV11_RS09095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNV11_RS09100	COG1570	exodeoxyribonuclease VII activity
HNV11_RS09105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HNV11_RS09115	COG5000	phosphorelay sensor kinase activity
HNV11_RS09115	COG3279	Response regulator of the LytR AlgR family
HNV11_RS09125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HNV11_RS09140	COG2207	Transcriptional regulator
HNV11_RS09140	COG0662	Cupin 2, conserved barrel domain protein
HNV11_RS09150	COG0673	inositol 2-dehydrogenase activity
HNV11_RS09175	COG0366	Alpha amylase catalytic
HNV11_RS09195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HNV11_RS09200	COG4712	double-strand break repair protein
HNV11_RS09210	COG2211	Major facilitator Superfamily
HNV11_RS09215	COG0708	Exodeoxyribonuclease III
HNV11_RS09220	COG1187	pseudouridine synthase activity
HNV11_RS09245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HNV11_RS09245	COG1199	ATP-dependent helicase activity
HNV11_RS09270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HNV11_RS09290	COG1607	acyl-coa hydrolase
HNV11_RS09330	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNV11_RS09335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HNV11_RS09335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HNV11_RS09355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HNV11_RS09370	COG0656	L-ascorbic acid biosynthetic process
HNV11_RS09380	COG0667	Aldo Keto reductase
HNV11_RS09390	COG0667	Aldo Keto reductase
HNV11_RS09395	COG0667	Aldo Keto reductase
HNV11_RS09415	COG0589	response to stress
HNV11_RS09420	COG0662	Cupin 2, conserved barrel domain protein
HNV11_RS09440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNV11_RS09440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HNV11_RS09460	COG0668	transmembrane transport
HNV11_RS09470	COG4771	TonB-dependent receptor
HNV11_RS09475	COG0702	epimerase
HNV11_RS09480	COG3119	arylsulfatase activity
HNV11_RS09485	COG3119	arylsulfatase activity
HNV11_RS09495	COG0189	ligase activity
HNV11_RS09495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HNV11_RS09510	COG4242	Belongs to the peptidase S51 family
HNV11_RS09540	COG1024	Enoyl-CoA hydratase
HNV11_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS09555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HNV11_RS09560	COG2080	2 iron, 2 sulfur cluster binding
HNV11_RS09565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HNV11_RS09570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HNV11_RS09580	COG4771	TonB-dependent receptor
HNV11_RS09610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HNV11_RS09620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNV11_RS09630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HNV11_RS09670	COG0531	amino acid
HNV11_RS09695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HNV11_RS09705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HNV11_RS09715	COG0544	peptidyl-prolyl cis-trans isomerase activity
HNV11_RS09735	COG0009	L-threonylcarbamoyladenylate synthase
HNV11_RS09740	COG1216	Glycosyl transferase, family 2
HNV11_RS09755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HNV11_RS09760	COG2201	protein-glutamate methylesterase activity
HNV11_RS09765	COG2201	protein-glutamate methylesterase activity
HNV11_RS09780	COG2197	response regulator
HNV11_RS09795	COG1335	isochorismatase
HNV11_RS09815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HNV11_RS09825	COG0714	Associated with various cellular activities
HNV11_RS09830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HNV11_RS09835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HNV11_RS09855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HNV11_RS09875	COG0482	sulfurtransferase activity
HNV11_RS09880	COG1404	Belongs to the peptidase S8 family
HNV11_RS09885	COG1136	(ABC) transporter
HNV11_RS09885	COG0577	efflux transmembrane transporter activity
HNV11_RS09910	COG0577	efflux transmembrane transporter activity
HNV11_RS09915	COG3876	Protein conserved in bacteria
HNV11_RS09940	COG0135	phosphoribosylanthranilate isomerase activity
HNV11_RS09945	COG1983	PspC domain protein
HNV11_RS09955	COG2814	Major facilitator Superfamily
HNV11_RS09975	COG1064	alcohol dehydrogenase
HNV11_RS09995	COG1595	DNA-templated transcription, initiation
HNV11_RS10000	COG3958	Transketolase
HNV11_RS10010	COG1196	nuclear chromosome segregation
HNV11_RS10015	COG3959	Transketolase, thiamine diphosphate binding domain
HNV11_RS10020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HNV11_RS10030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HNV11_RS10040	COG0045	succinate-CoA ligase (ADP-forming) activity
HNV11_RS10045	COG1136	(ABC) transporter
HNV11_RS10050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNV11_RS10055	COG0174	glutamine synthetase
HNV11_RS10075	COG0542	response to heat
HNV11_RS10105	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HNV11_RS10120	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNV11_RS10125	COG1546	Belongs to the CinA family
HNV11_RS10125	COG1058	Belongs to the CinA family
HNV11_RS10150	COG2315	Protein conserved in bacteria
HNV11_RS10160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HNV11_RS10170	COG0714	Associated with various cellular activities
HNV11_RS10175	COG2890	protein-(glutamine-N5) methyltransferase activity
HNV11_RS10190	COG1629	transport
HNV11_RS10195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HNV11_RS10205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HNV11_RS10210	COG0586	Pfam SNARE associated Golgi protein
HNV11_RS10215	COG1809	phosphosulfolactate synthase activity
HNV11_RS10225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HNV11_RS10230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HNV11_RS10245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HNV11_RS10250	COG4771	TonB-dependent receptor
HNV11_RS10265	COG1629	transport
HNV11_RS10265	COG4206	TonB-dependent receptor
HNV11_RS10280	COG1132	(ABC) transporter
HNV11_RS10285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HNV11_RS10295	COG2003	Belongs to the UPF0758 family
HNV11_RS10300	COG0268	Binds directly to 16S ribosomal RNA
HNV11_RS10315	COG1289	transmembrane transporter activity
HNV11_RS10320	COG0698	ribose 5-phosphate isomerase
HNV11_RS10325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HNV11_RS10330	COG1917	Cupin 2, conserved barrel domain protein
HNV11_RS10335	COG0363	glucosamine-6-phosphate deaminase activity
HNV11_RS10360	COG1715	Restriction endonuclease
HNV11_RS10425	COG3485	protocatechuate 3,4-dioxygenase
HNV11_RS10460	COG0154	amidase activity
HNV11_RS10485	COG2382	esterase
HNV11_RS10485	COG3693	PFAM glycoside hydrolase, family 10
HNV11_RS10485	COG3507	Belongs to the glycosyl hydrolase 43 family
HNV11_RS10505	COG3693	PFAM glycoside hydrolase, family 10
HNV11_RS10505	COG3507	Belongs to the glycosyl hydrolase 43 family
HNV11_RS10505	COG2382	esterase
HNV11_RS10510	COG2382	esterase
HNV11_RS10520	COG0657	acetylesterase activity
HNV11_RS10520	COG2755	lipolytic protein G-D-S-L family
HNV11_RS10525	COG2382	esterase
HNV11_RS10530	COG3507	Belongs to the glycosyl hydrolase 43 family
HNV11_RS10545	COG4771	TonB-dependent receptor
HNV11_RS10570	COG0579	oxidoreductase
HNV11_RS10595	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HNV11_RS10640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HNV11_RS10655	COG4771	TonB-dependent receptor
HNV11_RS10665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HNV11_RS10670	COG1234	tRNA 3'-trailer cleavage
HNV11_RS10685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNV11_RS10690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HNV11_RS10710	COG2072	flavoprotein involved in K transport
HNV11_RS10755	COG2814	Major facilitator Superfamily
HNV11_RS10770	COG2851	Citrate transporter
HNV11_RS10785	COG2272	Belongs to the type-B carboxylesterase lipase family
HNV11_RS10810	COG3940	Belongs to the glycosyl hydrolase 43 family
HNV11_RS10825	COG0504	CTP synthase activity
HNV11_RS10830	COG0706	membrane insertase activity
HNV11_RS10840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HNV11_RS10850	COG0667	Aldo Keto reductase
HNV11_RS10855	COG2207	Transcriptional regulator
HNV11_RS10860	COG3119	arylsulfatase activity
HNV11_RS10890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNV11_RS10905	COG0823	Involved in the tonB-independent uptake of proteins
HNV11_RS10920	COG2755	lipolytic protein G-D-S-L family
HNV11_RS10920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HNV11_RS10930	COG4771	TonB-dependent receptor
HNV11_RS10950	COG0463	Glycosyl transferase, family 2
HNV11_RS10950	COG1216	Glycosyl transferase, family 2
HNV11_RS10965	COG0124	histidyl-tRNA synthetase
HNV11_RS10975	COG2226	methyltransferase
HNV11_RS10990	COG2226	methyltransferase
HNV11_RS11045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HNV11_RS11050	COG2153	protein acetylation
HNV11_RS11090	COG3250	beta-galactosidase activity
HNV11_RS11125	COG1136	(ABC) transporter
HNV11_RS11145	COG2204	response regulator
HNV11_RS11155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNV11_RS11160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNV11_RS11185	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HNV11_RS11205	COG4221	oxidoreductase activity
HNV11_RS11210	COG1064	alcohol dehydrogenase
HNV11_RS11245	COG2887	Belongs to the helicase family. UvrD subfamily
HNV11_RS11255	COG5002	protein histidine kinase activity
HNV11_RS11280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HNV11_RS11295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNV11_RS11335	COG1082	Xylose isomerase domain protein TIM barrel
HNV11_RS11340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HNV11_RS11345	COG0494	nUDIX hydrolase
HNV11_RS11365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HNV11_RS11375	COG0463	Glycosyl transferase, family 2
HNV11_RS11380	COG1054	Belongs to the UPF0176 family
HNV11_RS11385	COG1428	Deoxynucleoside kinase
HNV11_RS11415	COG3507	Belongs to the glycosyl hydrolase 43 family
HNV11_RS11420	COG1216	Glycosyl transferase, family 2
HNV11_RS11445	COG2244	polysaccharide biosynthetic process
HNV11_RS11515	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS11525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HNV11_RS11530	COG0305	Participates in initiation and elongation during chromosome replication
HNV11_RS11545	COG2201	protein-glutamate methylesterase activity
HNV11_RS11560	COG1733	regulation of RNA biosynthetic process
HNV11_RS11565	COG3239	Fatty acid desaturase
HNV11_RS11625	COG1764	response to oxidative stress
HNV11_RS11640	COG0693	protein deglycase activity
HNV11_RS11650	COG3537	Alpha-1,2-mannosidase
HNV11_RS11660	COG3250	beta-galactosidase activity
HNV11_RS11670	COG2226	methyltransferase
HNV11_RS11675	COG0745	RESPONSE REGULATOR receiver
HNV11_RS11690	COG0745	RESPONSE REGULATOR receiver
HNV11_RS11695	COG3275	phosphorelay sensor kinase activity
HNV11_RS11700	COG3279	Response regulator of the LytR AlgR family
HNV11_RS11705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HNV11_RS11710	COG3485	protocatechuate 3,4-dioxygenase
HNV11_RS11740	COG1609	Transcriptional regulator
HNV11_RS11740	COG2207	Transcriptional regulator
HNV11_RS11750	COG1629	transport
HNV11_RS11750	COG4206	TonB-dependent receptor
HNV11_RS11770	COG1921	L-seryl-tRNASec selenium transferase activity
HNV11_RS11785	COG0251	oxidation-reduction process
HNV11_RS11790	COG1921	L-seryl-tRNASec selenium transferase activity
HNV11_RS11835	COG1609	Transcriptional regulator
HNV11_RS11860	COG1702	phosphate starvation-inducible protein PhoH
HNV11_RS11875	COG0658	competence protein
HNV11_RS11875	COG2333	competence protein COMEC
HNV11_RS11890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HNV11_RS11910	COG0702	epimerase
HNV11_RS11915	COG4771	TonB-dependent receptor
HNV11_RS11920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HNV11_RS11920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HNV11_RS11965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HNV11_RS11970	COG1185	polyribonucleotide nucleotidyltransferase activity
HNV11_RS11975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HNV11_RS12015	COG2819	hydrolase of the alpha beta superfamily
HNV11_RS12020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HNV11_RS12045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HNV11_RS12060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HNV11_RS12070	COG2171	N-acyltransferase activity
HNV11_RS12085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HNV11_RS12120	COG2885	chlorophyll binding
HNV11_RS12125	COG0037	tRNA processing
HNV11_RS12150	COG4251	negative regulation of phosphorylation
HNV11_RS12165	COG0497	DNA recombination
HNV11_RS12175	COG1999	signal sequence binding
HNV11_RS12195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HNV11_RS12200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HNV11_RS12240	COG2378	regulation of single-species biofilm formation
HNV11_RS12245	COG1960	acyl-CoA dehydrogenase activity
HNV11_RS12250	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HNV11_RS12305	COG0443	Heat shock 70 kDa protein
HNV11_RS12325	COG1064	alcohol dehydrogenase
HNV11_RS12345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HNV11_RS12350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HNV11_RS12395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HNV11_RS12400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HNV11_RS12410	COG0116	Belongs to the methyltransferase superfamily
HNV11_RS12410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HNV11_RS12435	COG2949	membrane
HNV11_RS12450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HNV11_RS12455	COG3458	cephalosporin-C deacetylase activity
HNV11_RS12465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HNV11_RS12470	COG2154	pterin-4-alpha-carbinolamine dehydratase
HNV11_RS12475	COG0251	oxidation-reduction process
HNV11_RS12535	COG0252	asparaginase activity
HNV11_RS12540	COG0084	hydrolase, TatD family'
HNV11_RS12545	COG1215	transferase activity, transferring glycosyl groups
HNV11_RS12555	COG1216	Glycosyl transferase, family 2
HNV11_RS12565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HNV11_RS12575	COG0432	Pfam Uncharacterised protein family UPF0047
HNV11_RS12580	COG1331	Highly conserved protein containing a thioredoxin domain
HNV11_RS12600	COG2270	Major facilitator Superfamily
HNV11_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS12665	COG2271	Major facilitator Superfamily
HNV11_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS12680	COG0028	Belongs to the TPP enzyme family
HNV11_RS12690	COG4251	negative regulation of phosphorylation
HNV11_RS12700	COG1082	Xylose isomerase domain protein TIM barrel
HNV11_RS12715	COG3850	Histidine kinase
HNV11_RS12735	COG2197	response regulator
HNV11_RS12760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HNV11_RS12790	COG3279	Response regulator of the LytR AlgR family
HNV11_RS12800	COG1136	(ABC) transporter
HNV11_RS12805	COG1136	(ABC) transporter
HNV11_RS12805	COG0577	efflux transmembrane transporter activity
HNV11_RS12810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNV11_RS12830	COG0405	Gamma-glutamyltransferase
HNV11_RS12850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNV11_RS12855	COG0659	secondary active sulfate transmembrane transporter activity
HNV11_RS12875	COG0598	Magnesium transport protein CorA
HNV11_RS12905	COG0483	inositol monophosphate 1-phosphatase activity
HNV11_RS12910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HNV11_RS12930	COG2205	protein histidine kinase activity
HNV11_RS12930	COG3292	Two component regulator propeller
HNV11_RS12930	COG0745	RESPONSE REGULATOR receiver
HNV11_RS12985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HNV11_RS12990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HNV11_RS12995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HNV11_RS12995	COG3743	rRNA binding
HNV11_RS13020	COG3153	acetyltransferase
HNV11_RS13020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNV11_RS13025	COG5505	Protein of unknown function (DUF819)
HNV11_RS13030	COG4206	TonB-dependent receptor
HNV11_RS13030	COG1629	transport
HNV11_RS13040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HNV11_RS13045	COG0495	leucyl-tRNA aminoacylation
HNV11_RS13075	COG0730	response to heat
HNV11_RS13090	COG0175	sulfate reduction
HNV11_RS13095	COG0175	sulfate reduction
HNV11_RS13115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HNV11_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS13130	COG0302	gtp cyclohydrolase
HNV11_RS13135	COG0720	synthase
HNV11_RS13145	COG4251	negative regulation of phosphorylation
HNV11_RS13165	COG4591	ABC-type transport system involved in lipoprotein release permease component
HNV11_RS13170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HNV11_RS13185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HNV11_RS13225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNV11_RS13230	COG3604	Transcriptional regulator
HNV11_RS13255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HNV11_RS13260	COG0459	protein refolding
HNV11_RS13265	COG0004	ammonium transporteR
HNV11_RS13275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HNV11_RS13340	COG0714	Associated with various cellular activities
HNV11_RS13380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HNV11_RS13395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HNV11_RS13420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HNV11_RS13430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HNV11_RS13445	COG3275	phosphorelay sensor kinase activity
HNV11_RS13525	COG0772	Belongs to the SEDS family
HNV11_RS13535	COG3781	membrane
HNV11_RS13540	COG0288	reversible hydration of carbon dioxide
HNV11_RS13545	COG0515	serine threonine protein kinase
HNV11_RS13550	COG0515	serine threonine protein kinase
HNV11_RS13550	COG2815	serine threonine protein kinase
HNV11_RS13555	COG0631	protein serine/threonine phosphatase activity
HNV11_RS13575	COG0823	Involved in the tonB-independent uptake of proteins
HNV11_RS13580	COG1621	beta-fructofuranosidase activity
HNV11_RS13590	COG4771	TonB-dependent receptor
HNV11_RS13595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HNV11_RS13595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HNV11_RS13600	COG2814	Major facilitator Superfamily
HNV11_RS13610	COG0673	inositol 2-dehydrogenase activity
HNV11_RS13620	COG0702	epimerase
HNV11_RS13625	COG4771	TonB-dependent receptor
HNV11_RS13645	COG2205	protein histidine kinase activity
HNV11_RS13645	COG3292	Two component regulator propeller
HNV11_RS13645	COG0745	RESPONSE REGULATOR receiver
HNV11_RS13670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HNV11_RS13675	COG0784	Response regulator, receiver
HNV11_RS13675	COG2205	protein histidine kinase activity
HNV11_RS13685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HNV11_RS13695	COG2271	Major facilitator Superfamily
HNV11_RS13700	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HNV11_RS13715	COG2382	esterase
HNV11_RS13740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HNV11_RS13755	COG0546	phosphoglycolate phosphatase activity
HNV11_RS13780	COG1556	Lactate utilization protein
HNV11_RS13785	COG1139	Iron-sulfur cluster binding protein
HNV11_RS13790	COG0247	lactate metabolic process
HNV11_RS13800	COG4952	isomerase
HNV11_RS13805	COG3347	Dehydrogenase
HNV11_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS13810	COG2755	lipolytic protein G-D-S-L family
HNV11_RS13815	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HNV11_RS13830	COG4251	negative regulation of phosphorylation
HNV11_RS13835	COG0577	efflux transmembrane transporter activity
HNV11_RS13850	COG2081	HI0933 family
HNV11_RS13855	COG0739	heme binding
HNV11_RS13865	COG2885	chlorophyll binding
HNV11_RS13870	COG0602	queuosine metabolic process
HNV11_RS13880	COG4680	protein conserved in bacteria
HNV11_RS13900	COG0673	inositol 2-dehydrogenase activity
HNV11_RS13915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HNV11_RS13930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HNV11_RS13960	COG0101	tRNA pseudouridine synthase activity
HNV11_RS14005	COG4152	abc transporter atp-binding protein
HNV11_RS14010	COG1301	dicarboxylic acid transport
HNV11_RS14020	COG2205	protein histidine kinase activity
HNV11_RS14020	COG0745	RESPONSE REGULATOR receiver
HNV11_RS14020	COG2205	protein histidine kinase activity
HNV11_RS14020	COG3292	Two component regulator propeller
HNV11_RS14020	COG3292	Two component regulator propeller
HNV11_RS14020	COG0745	RESPONSE REGULATOR receiver
HNV11_RS14030	COG0423	glycine-tRNA ligase activity
HNV11_RS14050	COG1940	carbohydrate kinase activity
HNV11_RS14060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HNV11_RS14085	COG1045	serine acetyltransferase
HNV11_RS14100	COG1611	Belongs to the LOG family
HNV11_RS14105	COG0698	ribose 5-phosphate isomerase
HNV11_RS14110	COG0436	Aminotransferase
HNV11_RS14130	COG1640	4-alpha-glucanotransferase
HNV11_RS14135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HNV11_RS14155	COG2135	peptidase activity
HNV11_RS14165	COG1086	Polysaccharide biosynthesis protein
HNV11_RS14180	COG0366	Alpha amylase catalytic
HNV11_RS14185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HNV11_RS14195	COG0025	NhaP-type Na H and K H
HNV11_RS14205	COG0484	heat shock protein binding
HNV11_RS14210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HNV11_RS14215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HNV11_RS14285	COG0339	signal peptide processing
HNV11_RS14305	COG2072	flavoprotein involved in K transport
HNV11_RS14320	COG2217	Heavy metal translocating P-type atpase
HNV11_RS14325	COG0612	Peptidase, M16
HNV11_RS14335	COG0697	spore germination
HNV11_RS14350	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS14355	COG0129	dihydroxy-acid dehydratase activity
HNV11_RS14370	COG0739	heme binding
HNV11_RS14370	COG1196	nuclear chromosome segregation
HNV11_RS14370	COG0741	lytic transglycosylase activity
HNV11_RS14375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HNV11_RS14380	COG1127	ABC transporter
HNV11_RS14390	COG3781	membrane
HNV11_RS14410	COG1047	Peptidyl-prolyl cis-trans
HNV11_RS14420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNV11_RS14425	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS14435	COG2080	2 iron, 2 sulfur cluster binding
HNV11_RS14440	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HNV11_RS14445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HNV11_RS14495	COG0442	prolyl-tRNA aminoacylation
HNV11_RS14525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HNV11_RS14565	COG2207	Transcriptional regulator
HNV11_RS14570	COG1012	belongs to the aldehyde dehydrogenase family
HNV11_RS14630	COG1175	transmembrane transport
HNV11_RS14635	COG0395	ABC-type sugar transport system, permease component
HNV11_RS14650	COG3842	ATPase activity
HNV11_RS14670	COG2133	pyrroloquinoline quinone binding
HNV11_RS14670	COG5183	chlorophyll binding
HNV11_RS14690	COG3279	Response regulator of the LytR AlgR family
HNV11_RS14720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNV11_RS14745	COG2814	Major facilitator Superfamily
HNV11_RS14755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNV11_RS14765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HNV11_RS14775	COG0101	tRNA pseudouridine synthase activity
HNV11_RS14795	COG0402	S-adenosylhomocysteine deaminase activity
HNV11_RS14800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HNV11_RS14805	COG0513	Belongs to the DEAD box helicase family
HNV11_RS14810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HNV11_RS14815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HNV11_RS14830	COG0242	peptide deformylase activity
HNV11_RS14835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HNV11_RS14845	COG1074	ATP-dependent DNA helicase activity
HNV11_RS14855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HNV11_RS14860	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HNV11_RS14865	COG2177	Part of the ABC transporter FtsEX involved in
HNV11_RS14875	COG1968	undecaprenyl-diphosphatase activity
HNV11_RS14880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HNV11_RS14885	COG0196	riboflavin kinase activity
HNV11_RS14900	COG0180	Tryptophanyl-tRNA synthetase
HNV11_RS14910	COG1082	Xylose isomerase domain protein TIM barrel
HNV11_RS14945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HNV11_RS14950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HNV11_RS14960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HNV11_RS14985	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HNV11_RS15000	COG0494	nUDIX hydrolase
HNV11_RS15015	COG0145	ligase activity
HNV11_RS15040	COG0604	alcohol dehydrogenase
HNV11_RS15040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HNV11_RS15040	COG3321	synthase
HNV11_RS15040	COG4221	oxidoreductase activity
HNV11_RS15045	COG0783	Belongs to the Dps family
HNV11_RS15055	COG1914	H( )-stimulated, divalent metal cation uptake system
HNV11_RS15085	COG2086	electron transfer activity
HNV11_RS15090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HNV11_RS15105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HNV11_RS15115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HNV11_RS15140	COG3685	Protein conserved in bacteria
HNV11_RS15145	COG0123	including yeast histone deacetylase and acetoin utilization protein
HNV11_RS15165	COG3685	Protein conserved in bacteria
HNV11_RS15195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HNV11_RS15200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HNV11_RS15205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HNV11_RS15260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HNV11_RS15275	COG4941	Belongs to the sigma-70 factor family
HNV11_RS15295	COG0564	pseudouridine synthase activity
HNV11_RS15310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HNV11_RS15315	COG0784	Response regulator, receiver
HNV11_RS15320	COG4251	negative regulation of phosphorylation
HNV11_RS15325	COG1404	Belongs to the peptidase S8 family
HNV11_RS15330	COG0336	Belongs to the RNA methyltransferase TrmD family
HNV11_RS15335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HNV11_RS15340	COG0228	four-way junction DNA binding
HNV11_RS15345	COG0629	single-stranded DNA binding
HNV11_RS15355	COG4974	Belongs to the 'phage' integrase family
HNV11_RS15370	COG0110	maltose O-acetyltransferase activity
HNV11_RS15385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HNV11_RS15430	COG1193	negative regulation of DNA recombination
HNV11_RS15440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HNV11_RS15455	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS15465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HNV11_RS15480	COG0542	response to heat
HNV11_RS15500	COG2610	gluconate transmembrane transporter activity
HNV11_RS15525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HNV11_RS15525	COG1796	DNA polymerase
HNV11_RS15545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HNV11_RS15550	COG1765	OsmC-like protein
HNV11_RS15565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HNV11_RS15565	COG1648	precorrin-2 dehydrogenase activity
HNV11_RS15585	COG0166	Belongs to the GPI family
HNV11_RS15595	COG3757	hydrolase, family 25
HNV11_RS15605	COG0450	alkyl hydroperoxide reductase
HNV11_RS15610	COG2197	response regulator
HNV11_RS15615	COG4585	Histidine kinase
HNV11_RS15635	COG0791	NLP P60 protein
HNV11_RS15645	COG1278	Cold shock
HNV11_RS15655	COG0673	inositol 2-dehydrogenase activity
HNV11_RS15675	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HNV11_RS15680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HNV11_RS15685	COG1605	Chorismate mutase
HNV11_RS15685	COG0077	Prephenate dehydratase
HNV11_RS15740	COG2755	lipolytic protein G-D-S-L family
HNV11_RS15740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HNV11_RS15785	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS15790	COG0297	glycogen (starch) synthase activity
HNV11_RS15790	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS15800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HNV11_RS15825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HNV11_RS15830	COG0596	Alpha beta hydrolase
HNV11_RS15835	COG4251	negative regulation of phosphorylation
HNV11_RS15900	COG0656	L-ascorbic acid biosynthetic process
HNV11_RS15920	COG2080	2 iron, 2 sulfur cluster binding
HNV11_RS15925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HNV11_RS15930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HNV11_RS15935	COG0110	maltose O-acetyltransferase activity
HNV11_RS15940	COG0657	acetylesterase activity
HNV11_RS15950	COG0300	oxidoreductase activity
HNV11_RS15965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HNV11_RS15975	COG0702	epimerase
HNV11_RS16000	COG0183	Belongs to the thiolase family
HNV11_RS16025	COG0564	pseudouridine synthase activity
HNV11_RS16030	COG0300	oxidoreductase activity
HNV11_RS16080	COG1360	Flagellar Motor Protein
HNV11_RS16095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HNV11_RS16105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HNV11_RS16105	COG0321	lipoyl(octanoyl) transferase activity
HNV11_RS16120	COG0784	Response regulator, receiver
HNV11_RS16120	COG2198	Histidine kinase
HNV11_RS16120	COG5002	protein histidine kinase activity
HNV11_RS16185	COG0545	Peptidyl-prolyl cis-trans isomerase
HNV11_RS16190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HNV11_RS16195	COG2239	Acts as a magnesium transporter
HNV11_RS16205	COG2311	Membrane
HNV11_RS16220	COG1215	transferase activity, transferring glycosyl groups
HNV11_RS16245	COG1301	dicarboxylic acid transport
HNV11_RS16250	COG1929	Belongs to the glycerate kinase type-1 family
HNV11_RS16255	COG2610	gluconate transmembrane transporter activity
HNV11_RS16260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HNV11_RS16265	COG1312	Catalyzes the dehydration of D-mannonate
HNV11_RS16270	COG1904	glucuronate isomerase
HNV11_RS16275	COG0492	ferredoxin-NADP+ reductase activity
HNV11_RS16280	COG0633	Ferredoxin
HNV11_RS16285	COG0251	oxidation-reduction process
HNV11_RS16320	COG2963	transposase activity
HNV11_RS16325	COG2801	Transposase and inactivated derivatives
HNV11_RS16330	COG2801	Transposase and inactivated derivatives
HNV11_RS16380	COG0339	signal peptide processing
HNV11_RS16395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HNV11_RS16405	COG3655	Transcriptional regulator
HNV11_RS16420	COG2353	YceI-like domain
HNV11_RS16425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HNV11_RS16430	COG2318	DinB family
HNV11_RS16455	COG0612	Peptidase, M16
HNV11_RS16470	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HNV11_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS16495	COG0584	glycerophosphoryl diester phosphodiesterase
HNV11_RS16510	COG1858	cytochrome C peroxidase
HNV11_RS16540	COG2133	pyrroloquinoline quinone binding
HNV11_RS16570	COG0513	Belongs to the DEAD box helicase family
HNV11_RS16600	COG2271	Major facilitator Superfamily
HNV11_RS16605	COG0800	Aldolase
HNV11_RS16610	COG3734	2-keto-3-deoxy-galactonokinase
HNV11_RS16630	COG1629	transport
HNV11_RS16640	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS16650	COG4206	TonB-dependent receptor
HNV11_RS16650	COG1629	transport
HNV11_RS16655	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS16670	COG3275	phosphorelay sensor kinase activity
HNV11_RS16675	COG0513	Belongs to the DEAD box helicase family
HNV11_RS16695	COG0513	Belongs to the DEAD box helicase family
HNV11_RS16735	COG1063	alcohol dehydrogenase
HNV11_RS16765	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HNV11_RS16785	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HNV11_RS16800	COG2814	Major facilitator Superfamily
HNV11_RS16820	COG0564	pseudouridine synthase activity
HNV11_RS16845	COG0673	inositol 2-dehydrogenase activity
HNV11_RS16860	COG4251	negative regulation of phosphorylation
HNV11_RS16870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HNV11_RS16905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HNV11_RS16910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HNV11_RS16925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HNV11_RS16950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HNV11_RS16955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HNV11_RS16960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HNV11_RS16965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HNV11_RS16995	COG1960	acyl-CoA dehydrogenase activity
HNV11_RS17000	COG0429	hydrolase of the alpha beta-hydrolase fold
HNV11_RS17005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HNV11_RS17010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HNV11_RS17040	COG1228	amidohydrolase
HNV11_RS17060	COG3291	Pkd domain containing protein
HNV11_RS17075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HNV11_RS17080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HNV11_RS17095	COG0076	glutamate decarboxylase activity
HNV11_RS17105	COG1703	isobutyryl-CoA mutase activity
HNV11_RS17110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HNV11_RS17135	COG4771	TonB-dependent receptor
HNV11_RS17140	COG4206	TonB-dependent receptor
HNV11_RS17140	COG1629	transport
HNV11_RS17155	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HNV11_RS17220	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HNV11_RS17225	COG0531	amino acid
HNV11_RS17230	COG1131	(ABC) transporter
HNV11_RS17240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HNV11_RS17245	COG2271	Major facilitator Superfamily
HNV11_RS17255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HNV11_RS17270	COG4771	TonB-dependent receptor
HNV11_RS17285	COG1216	Glycosyl transferase, family 2
HNV11_RS17290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNV11_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS17305	COG0612	Peptidase, M16
HNV11_RS17310	COG1694	Mazg nucleotide pyrophosphohydrolase
HNV11_RS17320	COG1595	DNA-templated transcription, initiation
HNV11_RS17330	COG4771	TonB-dependent receptor
HNV11_RS17335	COG0561	phosphatase activity
HNV11_RS17340	COG3940	Belongs to the glycosyl hydrolase 43 family
HNV11_RS17350	COG1252	NADH dehydrogenase
HNV11_RS17355	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS17375	COG1858	cytochrome C peroxidase
HNV11_RS17410	COG2329	Antibiotic biosynthesis monooxygenase
HNV11_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS17450	COG0667	Aldo Keto reductase
HNV11_RS17460	COG4221	oxidoreductase activity
HNV11_RS17465	COG3483	tryptophan 2,3-dioxygenase activity
HNV11_RS17515	COG0154	amidase activity
HNV11_RS17555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HNV11_RS17565	COG1381	Involved in DNA repair and RecF pathway recombination
HNV11_RS17585	COG1137	ATPase activity
HNV11_RS17590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HNV11_RS17590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HNV11_RS17600	COG0517	IMP dehydrogenase activity
HNV11_RS17600	COG0516	GMP reductase activity
HNV11_RS17620	COG3956	TIGRFAM MazG family protein
HNV11_RS17645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HNV11_RS17705	COG2192	nodulation
HNV11_RS17730	COG1086	Polysaccharide biosynthesis protein
HNV11_RS17735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HNV11_RS17745	COG1083	cytidylyl-transferase
HNV11_RS17760	COG2089	acid synthase
HNV11_RS17775	COG0438	transferase activity, transferring glycosyl groups
HNV11_RS17785	COG0205	6-phosphofructokinase activity
HNV11_RS17790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HNV11_RS17820	COG0012	GTP binding
HNV11_RS17830	COG3781	membrane
HNV11_RS17835	COG0488	(ABC) transporter
HNV11_RS17845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HNV11_RS17850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HNV11_RS17870	COG0436	Aminotransferase
HNV11_RS17885	COG0531	amino acid
HNV11_RS17925	COG1629	transport
HNV11_RS17940	COG2205	protein histidine kinase activity
HNV11_RS17960	COG1538	Outer membrane efflux protein
HNV11_RS17965	COG4251	negative regulation of phosphorylation
HNV11_RS17980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HNV11_RS17995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HNV11_RS18010	COG0737	Belongs to the 5'-nucleotidase family
HNV11_RS18015	COG0737	Belongs to the 5'-nucleotidase family
HNV11_RS18020	COG0047	phosphoribosylformylglycinamidine synthase activity
HNV11_RS18025	COG1902	pentaerythritol trinitrate reductase activity
HNV11_RS18045	COG1007	ATP synthesis coupled electron transport
HNV11_RS18050	COG1253	flavin adenine dinucleotide binding
HNV11_RS18070	COG4181	ATPase activity
HNV11_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS18095	COG4133	protoheme IX ABC transporter activity
HNV11_RS18100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNV11_RS18105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HNV11_RS18105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HNV11_RS18110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNV11_RS18115	COG1078	dGTPase activity
HNV11_RS18125	COG4771	TonB-dependent receptor
HNV11_RS18130	COG4251	negative regulation of phosphorylation
HNV11_RS18135	COG4251	negative regulation of phosphorylation
HNV11_RS18150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HNV11_RS18160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HNV11_RS18205	COG1215	transferase activity, transferring glycosyl groups
HNV11_RS18230	COG3206	protein involved in exopolysaccharide biosynthesis
HNV11_RS18230	COG0489	protein tyrosine kinase activity
HNV11_RS18240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HNV11_RS18245	COG0343	queuine tRNA-ribosyltransferase activity
HNV11_RS18255	COG0357	Ribosomal RNA small subunit methyltransferase G
HNV11_RS18310	COG2160	L-arabinose isomerase activity
HNV11_RS18340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNV11_RS18340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HNV11_RS18345	COG0730	response to heat
HNV11_RS18365	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS18390	COG2205	protein histidine kinase activity
HNV11_RS18390	COG0784	Response regulator, receiver
HNV11_RS18405	COG1215	transferase activity, transferring glycosyl groups
HNV11_RS18440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HNV11_RS18475	COG0538	isocitrate dehydrogenase activity
HNV11_RS18495	COG1473	amidohydrolase
HNV11_RS18515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HNV11_RS18520	COG1404	Belongs to the peptidase S8 family
HNV11_RS18530	COG0366	Alpha amylase catalytic
HNV11_RS18560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HNV11_RS18580	COG1193	negative regulation of DNA recombination
HNV11_RS18605	COG0673	inositol 2-dehydrogenase activity
HNV11_RS18610	COG0673	inositol 2-dehydrogenase activity
HNV11_RS18630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HNV11_RS18645	COG3119	arylsulfatase activity
HNV11_RS18650	COG3940	Belongs to the glycosyl hydrolase 43 family
HNV11_RS18660	COG1917	Cupin 2, conserved barrel domain protein
HNV11_RS18670	COG0673	inositol 2-dehydrogenase activity
HNV11_RS18690	COG4585	Histidine kinase
HNV11_RS18705	COG2885	chlorophyll binding
HNV11_RS18755	COG4771	TonB-dependent receptor
HNV11_RS18795	COG3119	arylsulfatase activity
HNV11_RS18800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HNV11_RS18800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HNV11_RS18810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HNV11_RS18815	COG1172	Belongs to the binding-protein-dependent transport system permease family
HNV11_RS18820	COG1129	ABC transporter
HNV11_RS18845	COG3958	Transketolase
HNV11_RS18850	COG3959	Transketolase, thiamine diphosphate binding domain
HNV11_RS18855	COG2382	esterase
HNV11_RS18870	COG1349	DNA-binding transcription factor activity
HNV11_RS18895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HNV11_RS18895	COG0131	Imidazoleglycerol-phosphate dehydratase
HNV11_RS18905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNV11_RS18915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNV11_RS18925	COG0006	proline dipeptidase activity
HNV11_RS18980	COG1960	acyl-CoA dehydrogenase activity
HNV11_RS19000	COG1404	Belongs to the peptidase S8 family
HNV11_RS19020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HNV11_RS19040	COG0673	inositol 2-dehydrogenase activity
HNV11_RS19060	COG3118	belongs to the thioredoxin family
HNV11_RS19060	COG0492	ferredoxin-NADP+ reductase activity
HNV11_RS19090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HNV11_RS19095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HNV11_RS19100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HNV11_RS19110	COG3275	phosphorelay sensor kinase activity
HNV11_RS19115	COG3279	Response regulator of the LytR AlgR family
HNV11_RS19130	COG3104	oligopeptide transport
HNV11_RS19140	COG0514	ATP-dependent DNA helicase (RecQ)
HNV11_RS19170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HNV11_RS19180	COG2223	nitrite transmembrane transporter activity
HNV11_RS19185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HNV11_RS19190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HNV11_RS19205	COG0612	Peptidase, M16
HNV11_RS19220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HNV11_RS19230	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS19245	COG1506	peptidase
HNV11_RS19245	COG0823	Involved in the tonB-independent uptake of proteins
HNV11_RS19255	COG2197	response regulator
HNV11_RS19260	COG0673	inositol 2-dehydrogenase activity
HNV11_RS19265	COG1063	alcohol dehydrogenase
HNV11_RS19270	COG1401	restriction endodeoxyribonuclease activity
HNV11_RS19280	COG0527	aspartate kinase activity
HNV11_RS19280	COG0460	homoserine dehydrogenase
HNV11_RS19300	COG1132	(ABC) transporter
HNV11_RS19305	COG2197	response regulator
HNV11_RS19320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HNV11_RS19345	COG0237	dephospho-CoA kinase activity
HNV11_RS19360	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HNV11_RS19365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HNV11_RS19370	COG3186	Phenylalanine-4-hydroxylase
HNV11_RS19385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HNV11_RS19395	COG0405	Gamma-glutamyltransferase
HNV11_RS19400	COG2267	carboxylic ester hydrolase activity
HNV11_RS19420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HNV11_RS19440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HNV11_RS19475	COG0629	single-stranded DNA binding
HNV11_RS19485	COG0776	regulation of translation
HNV11_RS19495	COG1530	ribonuclease E activity
HNV11_RS19515	COG2197	response regulator
HNV11_RS19525	COG0358	DNA primase activity
HNV11_RS19550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HNV11_RS19555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HNV11_RS19560	COG1366	Belongs to the anti-sigma-factor antagonist family
HNV11_RS19565	COG1366	Belongs to the anti-sigma-factor antagonist family
HNV11_RS19570	COG2172	sigma factor antagonist activity
HNV11_RS19580	COG4251	negative regulation of phosphorylation
HNV11_RS19600	COG3548	integral membrane protein
HNV11_RS19615	COG0531	amino acid
HNV11_RS19620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HNV11_RS19625	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HNV11_RS19635	COG1845	cytochrome c oxidase, subunit III
HNV11_RS19640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HNV11_RS19650	COG1119	ATPase activity
HNV11_RS19705	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS19710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HNV11_RS19765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HNV11_RS19780	COG0277	FAD linked oxidase domain protein
HNV11_RS19780	COG0247	lactate metabolic process
HNV11_RS19805	COG0577	efflux transmembrane transporter activity
HNV11_RS19805	COG1136	(ABC) transporter
HNV11_RS19820	COG0577	efflux transmembrane transporter activity
HNV11_RS19830	COG1136	(ABC) transporter
HNV11_RS19830	COG0577	efflux transmembrane transporter activity
HNV11_RS19865	COG1595	DNA-templated transcription, initiation
HNV11_RS19875	COG1136	(ABC) transporter
HNV11_RS19875	COG0577	efflux transmembrane transporter activity
HNV11_RS19890	COG0577	efflux transmembrane transporter activity
HNV11_RS19915	COG1136	(ABC) transporter
HNV11_RS19915	COG0577	efflux transmembrane transporter activity
HNV11_RS19920	COG1136	(ABC) transporter
HNV11_RS19920	COG0577	efflux transmembrane transporter activity
HNV11_RS19940	COG0577	efflux transmembrane transporter activity
HNV11_RS19940	COG1136	(ABC) transporter
HNV11_RS19965	COG4191	Histidine kinase
HNV11_RS19970	COG0534	Mate efflux family protein
HNV11_RS19980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HNV11_RS19985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HNV11_RS20010	COG0494	nUDIX hydrolase
HNV11_RS20020	COG1404	Belongs to the peptidase S8 family
HNV11_RS20025	COG0436	Aminotransferase
HNV11_RS20030	COG0287	Prephenate dehydrogenase
HNV11_RS20035	COG0667	Aldo Keto reductase
HNV11_RS20070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HNV11_RS20075	COG0534	Mate efflux family protein
HNV11_RS20080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HNV11_RS20120	COG0745	RESPONSE REGULATOR receiver
HNV11_RS20120	COG2205	protein histidine kinase activity
HNV11_RS20120	COG3292	Two component regulator propeller
HNV11_RS20150	COG0628	permease
HNV11_RS20155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HNV11_RS20160	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HNV11_RS20170	COG0628	permease
HNV11_RS20175	COG2323	membrane
HNV11_RS20180	COG0668	transmembrane transport
HNV11_RS20225	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HNV11_RS20260	COG0561	phosphatase activity
HNV11_RS20265	COG4771	TonB-dependent receptor
HNV11_RS20280	COG1752	Esterase of the alpha-beta hydrolase superfamily
HNV11_RS20285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HNV11_RS20295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HNV11_RS20305	COG4251	negative regulation of phosphorylation
HNV11_RS20320	COG0492	ferredoxin-NADP+ reductase activity
HNV11_RS20325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HNV11_RS20330	COG0673	inositol 2-dehydrogenase activity
HNV11_RS20340	COG2226	methyltransferase
HNV11_RS20370	COG0363	glucosamine-6-phosphate deaminase activity
HNV11_RS20385	COG0673	inositol 2-dehydrogenase activity
HNV11_RS20420	COG0754	glutathionylspermidine amidase activity
HNV11_RS20430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HNV11_RS20455	COG0805	protein transport
HNV11_RS20460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HNV11_RS20490	COG0306	phosphate transporter
HNV11_RS20495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HNV11_RS20505	COG1610	YqeY-like protein
HNV11_RS20510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HNV11_RS20515	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HNV11_RS20525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HNV11_RS20560	COG0246	Mannitol dehydrogenase
HNV11_RS20580	COG1629	transport
HNV11_RS20595	COG2755	lipolytic protein G-D-S-L family
HNV11_RS20690	COG0542	response to heat
HNV11_RS20775	COG2223	nitrite transmembrane transporter activity
HNV11_RS20785	COG1053	succinate dehydrogenase
HNV11_RS20795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HNV11_RS20835	COG4771	TonB-dependent receptor
HNV11_RS20840	COG0277	FAD linked oxidase domain protein
HNV11_RS20840	COG0247	lactate metabolic process
HNV11_RS20880	COG0673	inositol 2-dehydrogenase activity
HNV11_RS20895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HNV11_RS20910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HNV11_RS20915	COG4953	penicillin-binding protein 1C
HNV11_RS20935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HNV11_RS20960	COG0811	peptide transport
HNV11_RS20990	COG0563	adenylate kinase activity
HNV11_RS20995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HNV11_RS21010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNV11_RS21015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNV11_RS21020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNV11_RS21025	COG0649	NAD binding
HNV11_RS21030	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HNV11_RS21040	COG1034	ATP synthesis coupled electron transport
HNV11_RS21045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HNV11_RS21050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HNV11_RS21055	COG0839	Belongs to the complex I subunit 6 family
HNV11_RS21060	COG0183	Belongs to the thiolase family
HNV11_RS21070	COG1960	acyl-CoA dehydrogenase activity
HNV11_RS21085	COG0673	inositol 2-dehydrogenase activity
HNV11_RS21110	COG1733	regulation of RNA biosynthetic process
HNV11_RS21115	COG3239	Fatty acid desaturase
HNV11_RS21140	COG0402	S-adenosylhomocysteine deaminase activity
HNV11_RS21145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HNV11_RS21150	COG2234	aminopeptidase activity
HNV11_RS21180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HNV11_RS21180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HNV11_RS21185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HNV11_RS21190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HNV11_RS21210	COG1136	(ABC) transporter
HNV11_RS21220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HNV11_RS21225	COG1160	GTP binding
HNV11_RS21240	COG2255	four-way junction helicase activity
HNV11_RS21255	COG0527	aspartate kinase activity
HNV11_RS21260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HNV11_RS21275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HNV11_RS21280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HNV11_RS21300	COG3279	Response regulator of the LytR AlgR family
HNV11_RS21310	COG0142	geranyltranstransferase activity
HNV11_RS21325	COG0557	exoribonuclease II activity
HNV11_RS21340	COG0321	lipoyl(octanoyl) transferase activity
HNV11_RS21345	COG0792	nuclease activity
HNV11_RS21450	COG1297	OPT oligopeptide transporter protein
HNV11_RS21455	COG4251	negative regulation of phosphorylation
HNV11_RS21465	COG1801	Protein of unknown function DUF72
HNV11_RS21505	COG0628	permease
HNV11_RS21510	COG2514	catechol 2,3-dioxygenase activity
HNV11_RS21525	COG4948	Mandelate Racemase Muconate Lactonizing
HNV11_RS21530	COG2706	6-phosphogluconolactonase activity
HNV11_RS21545	COG0049	tRNA binding
HNV11_RS21550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HNV11_RS21570	COG3047	cAMP biosynthetic process
HNV11_RS21570	COG2885	chlorophyll binding
HNV11_RS21600	COG0149	triose-phosphate isomerase activity
HNV11_RS21605	COG0750	zinc metalloprotease
HNV11_RS21610	COG5002	protein histidine kinase activity
HNV11_RS21615	COG0745	RESPONSE REGULATOR receiver
HNV11_RS21620	COG0628	permease
HNV11_RS21640	COG1960	acyl-CoA dehydrogenase activity
HNV11_RS21660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HNV11_RS21665	COG0416	fatty acid biosynthetic process
HNV11_RS21670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HNV11_RS21675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HNV11_RS21685	COG0439	Biotin carboxylase
HNV11_RS21710	COG0783	Belongs to the Dps family
HNV11_RS21715	COG0579	oxidoreductase
HNV11_RS21730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HNV11_RS21750	COG2223	nitrite transmembrane transporter activity
HNV11_RS21755	COG0243	molybdopterin cofactor binding
HNV11_RS21760	COG1773	rubredoxin
HNV11_RS21760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HNV11_RS21765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HNV11_RS21775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HNV11_RS21780	COG0604	alcohol dehydrogenase
HNV11_RS21785	COG0156	8-amino-7-oxononanoate synthase activity
HNV11_RS21790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HNV11_RS21795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HNV11_RS21815	COG3142	Participates in the control of copper homeostasis
HNV11_RS21825	COG0788	formyltetrahydrofolate deformylase activity
HNV11_RS21830	COG1446	asparaginase
HNV11_RS21840	COG0521	Mo-molybdopterin cofactor biosynthetic process
HNV11_RS21845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HNV11_RS21850	COG3001	Fructosamine kinase
HNV11_RS21855	COG0513	Belongs to the DEAD box helicase family
HNV11_RS21870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HNV11_RS21880	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HNV11_RS21920	COG2322	membrane
HNV11_RS21925	COG1999	signal sequence binding
HNV11_RS21935	COG1845	cytochrome c oxidase, subunit III
HNV11_RS21940	COG1845	cytochrome c oxidase, subunit III
HNV11_RS21945	COG0109	protoheme IX farnesyltransferase activity
HNV11_RS21950	COG1612	heme a metabolic process
HNV11_RS21955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HNV11_RS21960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HNV11_RS21985	COG0437	4 iron, 4 sulfur cluster binding
HNV11_RS22000	COG2183	response to ionizing radiation
HNV11_RS22000	COG0539	negative regulation of cytoplasmic translation
HNV11_RS22010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HNV11_RS22030	COG1595	DNA-templated transcription, initiation
HNV11_RS22040	COG4771	TonB-dependent receptor
HNV11_RS22055	COG0584	glycerophosphoryl diester phosphodiesterase
HNV11_RS22070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HNV11_RS22075	COG1649	PFAM Uncharacterised BCR, COG1649
HNV11_RS22085	COG1522	sequence-specific DNA binding
HNV11_RS22100	COG0649	NAD binding
HNV11_RS22105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HNV11_RS22115	COG0552	protein localization to endoplasmic reticulum
HNV11_RS22125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HNV11_RS22130	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HNV11_RS22135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HNV11_RS22140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HNV11_RS22150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HNV11_RS22165	COG0113	porphobilinogen synthase activity
HNV11_RS22195	COG1472	Belongs to the glycosyl hydrolase 3 family
HNV11_RS22230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HNV11_RS22245	COG0463	Glycosyl transferase, family 2
HNV11_RS22300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HNV11_RS22305	COG3119	arylsulfatase activity
HNV11_RS22330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HNV11_RS22340	COG0662	Cupin 2, conserved barrel domain protein
HNV11_RS22340	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HNV11_RS22350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HNV11_RS22360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNV11_RS22365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HNV11_RS22380	COG2885	chlorophyll binding
HNV11_RS22415	COG1956	GAF domain-containing protein
HNV11_RS22440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HNV11_RS22455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HNV11_RS22470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HNV11_RS22475	COG0129	dihydroxy-acid dehydratase activity
HNV11_RS22480	COG0028	Belongs to the TPP enzyme family
HNV11_RS22490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HNV11_RS22495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HNV11_RS22505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HNV11_RS22510	COG0066	3-isopropylmalate dehydratase activity
HNV11_RS22520	COG0473	3-isopropylmalate dehydrogenase activity
HNV11_RS22525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HNV11_RS22565	COG0420	3'-5' exonuclease activity
HNV11_RS22570	COG0419	ATPase involved in DNA repair
HNV11_RS22580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HNV11_RS22595	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HNV11_RS22600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HNV11_RS22610	COG0488	(ABC) transporter
HNV11_RS22625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HNV11_RS22630	COG1895	HEPN domain
HNV11_RS22640	COG0527	aspartate kinase activity
HNV11_RS22645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HNV11_RS22665	COG0626	cystathionine gamma-synthase activity
HNV11_RS22675	COG0596	Alpha beta hydrolase
HNV11_RS22685	COG1960	acyl-CoA dehydrogenase activity
HNV11_RS22700	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HNV11_RS22715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HNV11_RS22720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HNV11_RS22725	COG0688	phosphatidylethanolamine metabolic process
HNV11_RS22755	COG1285	pathogenesis
HNV11_RS22800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HNV11_RS22810	COG0138	bifunctional purine biosynthesis protein purh
HNV11_RS22830	COG2326	polyphosphate kinase activity
HNV11_RS22835	COG2326	polyphosphate kinase activity
HNV11_RS22840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNV11_RS22895	COG1505	serine-type exopeptidase activity
HNV11_RS22905	COG1199	ATP-dependent helicase activity
HNV11_RS22905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HNV11_RS22915	COG2264	protein methyltransferase activity
HNV11_RS22940	COG0215	cysteine-tRNA ligase activity
HNV11_RS22945	COG2234	aminopeptidase activity
HNV11_RS22955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HNV11_RS22960	COG0194	GDP metabolic process
HNV11_RS22970	COG1595	DNA-templated transcription, initiation
HNV11_RS22980	COG0247	lactate metabolic process
HNV11_RS22980	COG2181	nitrate reductase activity
HNV11_RS22985	COG0247	lactate metabolic process
HNV11_RS22985	COG2181	nitrate reductase activity
HNV11_RS23005	COG1132	(ABC) transporter
HNV11_RS23020	COG0107	imidazoleglycerol-phosphate synthase activity
HNV11_RS23030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HNV11_RS23055	COG0525	valine-tRNA ligase activity
HNV11_RS23070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HNV11_RS23105	COG1012	belongs to the aldehyde dehydrogenase family
HNV11_RS23110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HNV11_RS23125	COG0445	tRNA wobble uridine modification
HNV11_RS23140	COG1040	competence protein
HNV11_RS23145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HNV11_RS23150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HNV11_RS23170	COG0346	lactoylglutathione lyase activity
HNV11_RS23175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HNV11_RS23180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HNV11_RS23210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HNV11_RS23245	COG1217	gtp-binding protein TYPA
HNV11_RS23290	COG1595	DNA-templated transcription, initiation
HNV11_RS23315	COG0140	phosphoribosyl-ATP diphosphatase activity
HNV11_RS23315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HNV11_RS23320	COG0159	tryptophan synthase activity
HNV11_RS23325	COG0133	tryptophan synthase activity
HNV11_RS23330	COG0135	phosphoribosylanthranilate isomerase activity
HNV11_RS23335	COG0134	indole-3-glycerol-phosphate synthase activity
HNV11_RS23340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HNV11_RS23350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HNV11_RS23360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HNV11_RS23365	COG2723	6-phospho-beta-galactosidase activity
HNV11_RS23380	COG1028	Short-chain dehydrogenase reductase Sdr
HNV11_RS23390	COG0514	ATP-dependent DNA helicase (RecQ)
HNV11_RS23395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HNV11_RS23415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HNV11_RS23435	COG1959	2 iron, 2 sulfur cluster binding
HNV11_RS23455	COG0242	peptide deformylase activity
HNV11_RS23460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HNV11_RS23470	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HNV11_RS23500	COG0673	inositol 2-dehydrogenase activity
HNV11_RS23505	COG0363	glucosamine-6-phosphate deaminase activity
HNV11_RS23530	COG0612	Peptidase, M16
HNV11_RS23545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HNV11_RS23550	COG0531	amino acid
HNV11_RS23565	COG0022	dehydrogenase e1 component
HNV11_RS23565	COG0508	dehydrogenase complex catalyzes the overall conversion of
HNV11_RS23575	COG1957	nucleoside hydrolase
HNV11_RS23580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HNV11_RS23590	COG1435	thymidine kinase activity
HNV11_RS23605	COG1127	ABC transporter
HNV11_RS23610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HNV11_RS23615	COG0300	oxidoreductase activity
HNV11_RS23620	COG1940	carbohydrate kinase activity
HNV11_RS23625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HNV11_RS23635	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HNV11_RS23640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HNV11_RS23690	COG1396	sequence-specific DNA binding
HNV11_RS23710	COG1192	Involved in chromosome partitioning
HNV11_RS23765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily