locus-tag	class	description
I6N98_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6N98_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6N98_RS00030	COG0751	glycine-tRNA ligase activity
I6N98_RS00035	COG0752	glycyl-tRNA synthetase alpha subunit
I6N98_RS00050	COG3300	MHYT domain
I6N98_RS00050	COG5001	Diguanylate cyclase
I6N98_RS00060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6N98_RS00065	COG0569	domain protein
I6N98_RS00075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6N98_RS00080	COG0242	peptide deformylase activity
I6N98_RS00090	COG0758	DNA mediated transformation
I6N98_RS00095	COG0009	L-threonylcarbamoyladenylate synthase
I6N98_RS00100	COG0408	coproporphyrinogen oxidase activity
I6N98_RS00105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6N98_RS00135	COG0154	amidase activity
I6N98_RS00165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6N98_RS00170	COG0339	signal peptide processing
I6N98_RS00185	COG0647	UMP catabolic process
I6N98_RS00190	COG3268	Saccharopine dehydrogenase
I6N98_RS00200	COG0657	acetylesterase activity
I6N98_RS00205	COG0617	tRNA 3'-terminal CCA addition
I6N98_RS00205	COG0517	IMP dehydrogenase activity
I6N98_RS00205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6N98_RS00215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6N98_RS00220	COG0583	DNA-binding transcription factor activity
I6N98_RS00225	COG2318	DinB family
I6N98_RS00240	COG0534	Mate efflux family protein
I6N98_RS00245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6N98_RS00250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6N98_RS00260	COG1845	cytochrome c oxidase, subunit III
I6N98_RS00285	COG0109	protoheme IX farnesyltransferase activity
I6N98_RS00295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6N98_RS00300	COG1121	(ABC) transporter
I6N98_RS00305	COG0735	belongs to the Fur family
I6N98_RS00310	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6N98_RS00325	COG3093	addiction module antidote protein HigA
I6N98_RS00355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N98_RS00370	COG1858	cytochrome C peroxidase
I6N98_RS00410	COG1162	GTPase activity
I6N98_RS00450	COG4372	Transposase
I6N98_RS00465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6N98_RS00465	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6N98_RS00475	COG1074	ATP-dependent DNA helicase activity
I6N98_RS00490	COG2261	transglycosylase associated protein
I6N98_RS00495	COG1346	cytolysis
I6N98_RS00505	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6N98_RS00510	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6N98_RS00520	COG2837	iron assimilation
I6N98_RS00545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6N98_RS00565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6N98_RS00570	COG0678	peroxiredoxin activity
I6N98_RS00575	COG0071	Belongs to the small heat shock protein (HSP20) family
I6N98_RS00590	COG2267	carboxylic ester hydrolase activity
I6N98_RS00610	COG2095	MarC family integral membrane protein
I6N98_RS00620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6N98_RS00630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6N98_RS00630	COG2813	Specifically methylates the guanine in position
I6N98_RS00635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6N98_RS00640	COG1872	DUF167
I6N98_RS00700	COG3150	esterase
I6N98_RS00720	COG0702	epimerase
I6N98_RS00740	COG4372	Transposase
I6N98_RS00765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6N98_RS00765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6N98_RS00770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6N98_RS00785	COG0300	oxidoreductase activity
I6N98_RS00790	COG4774	siderophore transport
I6N98_RS00795	COG2124	cytochrome p450
I6N98_RS00805	COG2070	2-Nitropropane dioxygenase
I6N98_RS00810	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS00830	COG4771	TonB-dependent receptor
I6N98_RS00835	COG1773	rubredoxin
I6N98_RS00855	COG2271	Major facilitator Superfamily
I6N98_RS00895	COG2030	dehydratase
I6N98_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS00925	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS00960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6N98_RS00975	COG2205	protein histidine kinase activity
I6N98_RS00985	COG2204	response regulator
I6N98_RS00990	COG1280	lysine exporter protein (LysE YggA)
I6N98_RS00995	COG0861	Integral membrane protein TerC family
I6N98_RS01010	COG0778	Nitroreductase
I6N98_RS01020	COG0737	Belongs to the 5'-nucleotidase family
I6N98_RS01030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6N98_RS01040	COG0527	aspartate kinase activity
I6N98_RS01045	COG1917	Cupin 2, conserved barrel domain protein
I6N98_RS01050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6N98_RS01060	COG1846	Transcriptional regulator
I6N98_RS01070	COG3272	Protein of unknown function (DUF1722)
I6N98_RS01110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6N98_RS01120	COG1678	Uncharacterized ACR, COG1678
I6N98_RS01130	COG0189	ligase activity
I6N98_RS01150	COG0840	transmembrane signaling receptor activity
I6N98_RS01155	COG0643	Histidine kinase
I6N98_RS01155	COG0784	Response regulator, receiver
I6N98_RS01155	COG2198	Histidine kinase
I6N98_RS01165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6N98_RS01170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6N98_RS01170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6N98_RS01180	COG0583	DNA-binding transcription factor activity
I6N98_RS01200	COG2885	chlorophyll binding
I6N98_RS01215	COG0307	riboflavin synthase, alpha
I6N98_RS01220	COG2070	2-Nitropropane dioxygenase
I6N98_RS01235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6N98_RS01260	COG0017	Asparaginyl-tRNA synthetase
I6N98_RS01270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6N98_RS01285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6N98_RS01290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6N98_RS01300	COG0018	arginyl-trna synthetase
I6N98_RS01305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6N98_RS01310	COG0254	rRNA binding
I6N98_RS01320	COG0281	malic enzyme
I6N98_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS01340	COG1253	flavin adenine dinucleotide binding
I6N98_RS01350	COG0488	(ABC) transporter
I6N98_RS01365	COG0583	DNA-binding transcription factor activity
I6N98_RS01370	COG0300	oxidoreductase activity
I6N98_RS01380	COG1902	pentaerythritol trinitrate reductase activity
I6N98_RS01385	COG0300	oxidoreductase activity
I6N98_RS01395	COG2200	EAL domain
I6N98_RS01415	COG4774	siderophore transport
I6N98_RS01450	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS01460	COG0346	lactoylglutathione lyase activity
I6N98_RS01465	COG0300	oxidoreductase activity
I6N98_RS01480	COG4774	siderophore transport
I6N98_RS01490	COG1024	Enoyl-CoA hydratase
I6N98_RS01500	COG1024	Enoyl-CoA hydratase
I6N98_RS01505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6N98_RS01520	COG0511	ligase activity, forming carbon-carbon bonds
I6N98_RS01525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6N98_RS01530	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS01545	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS01585	COG5002	protein histidine kinase activity
I6N98_RS01590	COG0745	RESPONSE REGULATOR receiver
I6N98_RS01635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6N98_RS01655	COG3118	belongs to the thioredoxin family
I6N98_RS01660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6N98_RS01665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6N98_RS01670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6N98_RS01670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6N98_RS01685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6N98_RS01695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6N98_RS01700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6N98_RS01725	COG3264	Mechanosensitive ion channel
I6N98_RS01725	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6N98_RS01735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6N98_RS01750	COG2022	thiamine diphosphate biosynthetic process
I6N98_RS01780	COG0352	thiamine-phosphate diphosphorylase activity
I6N98_RS01790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6N98_RS01795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6N98_RS01800	COG0142	geranyltranstransferase activity
I6N98_RS01820	COG1970	mechanosensitive ion channel activity
I6N98_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS01830	COG1234	tRNA 3'-trailer cleavage
I6N98_RS01850	COG2124	cytochrome p450
I6N98_RS01855	COG0745	RESPONSE REGULATOR receiver
I6N98_RS01860	COG5002	protein histidine kinase activity
I6N98_RS01870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6N98_RS01875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6N98_RS01880	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6N98_RS01885	COG0412	Dienelactone hydrolase
I6N98_RS01905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6N98_RS01915	COG2885	chlorophyll binding
I6N98_RS01935	COG0235	Class ii aldolase
I6N98_RS01960	COG0515	serine threonine protein kinase
I6N98_RS01960	COG2815	serine threonine protein kinase
I6N98_RS01965	COG1716	ATPase activity
I6N98_RS01965	COG0842	Transport permease protein
I6N98_RS01965	COG1131	(ABC) transporter
I6N98_RS02005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6N98_RS02005	COG0493	'glutamate synthase
I6N98_RS02055	COG3039	Transposase
I6N98_RS02075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6N98_RS02075	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6N98_RS02080	COG3039	Transposase
I6N98_RS02100	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS02110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6N98_RS02115	COG1024	Enoyl-CoA hydratase
I6N98_RS02130	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS02170	COG3239	Fatty acid desaturase
I6N98_RS02195	COG2050	protein possibly involved in aromatic compounds catabolism
I6N98_RS02200	COG1309	transcriptional regulator
I6N98_RS02210	COG0633	Ferredoxin
I6N98_RS02225	COG2963	transposase activity
I6N98_RS02240	COG0633	Ferredoxin
I6N98_RS02255	COG1454	alcohol dehydrogenase
I6N98_RS02305	COG1061	Type III restriction enzyme res subunit
I6N98_RS02330	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6N98_RS02335	COG1194	a g-specific adenine glycosylase
I6N98_RS02350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6N98_RS02355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6N98_RS02360	COG0107	imidazoleglycerol-phosphate synthase activity
I6N98_RS02365	COG0793	Belongs to the peptidase S41A family
I6N98_RS02370	COG1388	LysM domain
I6N98_RS02370	COG4942	peptidase
I6N98_RS02375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6N98_RS02380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6N98_RS02390	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6N98_RS02395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6N98_RS02405	COG3852	Histidine kinase
I6N98_RS02415	COG0174	glutamine synthetase
I6N98_RS02420	COG0301	tRNA thio-modification
I6N98_RS02420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6N98_RS02435	COG0733	neurotransmitter:sodium symporter activity
I6N98_RS02445	COG1217	gtp-binding protein TYPA
I6N98_RS02455	COG1490	D-aminoacyl-tRNA deacylase activity
I6N98_RS02465	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6N98_RS02470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6N98_RS02475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6N98_RS02490	COG1301	dicarboxylic acid transport
I6N98_RS02525	COG3769	mannosylglycerate metabolic process
I6N98_RS02530	COG1215	transferase activity, transferring glycosyl groups
I6N98_RS02535	COG0366	Alpha amylase catalytic
I6N98_RS02540	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS02545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6N98_RS02555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6N98_RS02560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6N98_RS02565	COG1428	Deoxynucleoside kinase
I6N98_RS02585	COG3852	Histidine kinase
I6N98_RS02595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6N98_RS02605	COG0436	Aminotransferase
I6N98_RS02630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6N98_RS02635	COG1981	membrane
I6N98_RS02645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6N98_RS02650	COG0316	Belongs to the HesB IscA family
I6N98_RS02655	COG3047	cAMP biosynthetic process
I6N98_RS02660	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6N98_RS02665	COG0739	heme binding
I6N98_RS02715	COG1741	Belongs to the pirin family
I6N98_RS02720	COG1254	Belongs to the acylphosphatase family
I6N98_RS02725	COG0625	glutathione transferase activity
I6N98_RS02740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6N98_RS02775	COG0513	Belongs to the DEAD box helicase family
I6N98_RS02785	COG0789	Transcriptional regulator
I6N98_RS02790	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6N98_RS02790	COG1902	pentaerythritol trinitrate reductase activity
I6N98_RS02800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6N98_RS02825	COG4372	Transposase
I6N98_RS02845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6N98_RS02850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6N98_RS02850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6N98_RS02855	COG3842	ATPase activity
I6N98_RS02865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6N98_RS02870	COG4771	TonB-dependent receptor
I6N98_RS02880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6N98_RS02895	COG4772	TonB-dependent receptor
I6N98_RS02920	COG0450	alkyl hydroperoxide reductase
I6N98_RS02930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6N98_RS02935	COG0418	dihydroorotase activity
I6N98_RS02940	COG1555	photosystem II stabilization
I6N98_RS02945	COG0137	argininosuccinate synthase activity
I6N98_RS02955	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6N98_RS02960	COG4191	Histidine kinase
I6N98_RS02980	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS02985	COG0006	proline dipeptidase activity
I6N98_RS02990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6N98_RS02995	COG1473	amidohydrolase
I6N98_RS03020	COG4771	TonB-dependent receptor
I6N98_RS03025	COG2199	diguanylate cyclase activity
I6N98_RS03035	COG3001	Fructosamine kinase
I6N98_RS03040	COG0513	Belongs to the DEAD box helicase family
I6N98_RS03045	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6N98_RS03055	COG1187	pseudouridine synthase activity
I6N98_RS03060	COG2813	Specifically methylates the guanine in position
I6N98_RS03070	COG1489	DNA binding
I6N98_RS03080	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6N98_RS03085	COG1876	peptidase activity
I6N98_RS03090	COG1045	serine acetyltransferase
I6N98_RS03110	COG0789	Transcriptional regulator
I6N98_RS03120	COG2146	nitrite reductase [NAD(P)H] activity
I6N98_RS03120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6N98_RS03125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6N98_RS03130	COG2223	nitrite transmembrane transporter activity
I6N98_RS03180	COG0811	peptide transport
I6N98_RS03210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6N98_RS03225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6N98_RS03235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6N98_RS03240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6N98_RS03255	COG0768	penicillin binding
I6N98_RS03260	COG0772	Belongs to the SEDS family
I6N98_RS03265	COG2951	lytic endotransglycosylase activity
I6N98_RS03275	COG1686	Belongs to the peptidase S11 family
I6N98_RS03280	COG2921	Belongs to the UPF0250 family
I6N98_RS03285	COG0321	lipoyl(octanoyl) transferase activity
I6N98_RS03290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6N98_RS03295	COG4115	mRNA cleavage
I6N98_RS03300	COG2161	toxin-antitoxin pair type II binding
I6N98_RS03310	COG0477	Major facilitator Superfamily
I6N98_RS03320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6N98_RS03320	COG0519	Catalyzes the synthesis of GMP from XMP
I6N98_RS03335	COG0659	secondary active sulfate transmembrane transporter activity
I6N98_RS03345	COG2824	Alkylphosphonate utilization operon protein PhnA
I6N98_RS03350	COG3384	dioxygenase
I6N98_RS03370	COG0667	Aldo Keto reductase
I6N98_RS03375	COG0640	Transcriptional regulator
I6N98_RS03385	COG0798	PFAM Bile acid sodium symporter
I6N98_RS03390	COG0431	NADPH-dependent FMN reductase
I6N98_RS03395	COG5285	phytanoyl-CoA dioxygenase
I6N98_RS03400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6N98_RS03405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6N98_RS03425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6N98_RS03455	COG0784	Response regulator, receiver
I6N98_RS03455	COG2198	Histidine kinase
I6N98_RS03455	COG5002	protein histidine kinase activity
I6N98_RS03470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6N98_RS03475	COG2363	Small membrane protein
I6N98_RS03485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6N98_RS03495	COG3072	Adenylate cyclase
I6N98_RS03510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6N98_RS03525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6N98_RS03530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6N98_RS03545	COG0742	ribosomal rna small subunit methyltransferase
I6N98_RS03550	COG0552	protein localization to endoplasmic reticulum
I6N98_RS03555	COG2884	Cell division ATP-binding protein ftsE
I6N98_RS03560	COG2177	Part of the ABC transporter FtsEX involved in
I6N98_RS03565	COG4535	Mg2 and Co2 transporter CorC
I6N98_RS03575	COG1702	phosphate starvation-inducible protein PhoH
I6N98_RS03580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6N98_RS03595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6N98_RS03600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6N98_RS03605	COG0140	phosphoribosyl-ATP diphosphatase activity
I6N98_RS03610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6N98_RS03615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6N98_RS03625	COG2226	methyltransferase
I6N98_RS03640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6N98_RS03675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6N98_RS03680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6N98_RS03685	COG0069	glutamate synthase activity
I6N98_RS03685	COG0067	glutamate synthase
I6N98_RS03685	COG0070	glutamate synthase
I6N98_RS03690	COG0493	'glutamate synthase
I6N98_RS03695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6N98_RS03715	COG0519	Catalyzes the synthesis of GMP from XMP
I6N98_RS03720	COG4783	chaperone-mediated protein folding
I6N98_RS03725	COG1045	serine acetyltransferase
I6N98_RS03735	COG0110	maltose O-acetyltransferase activity
I6N98_RS03745	COG1131	(ABC) transporter
I6N98_RS03750	COG0842	Transport permease protein
I6N98_RS03760	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS03790	COG1040	competence protein
I6N98_RS03795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6N98_RS03800	COG0156	8-amino-7-oxononanoate synthase activity
I6N98_RS03805	COG2226	methyltransferase
I6N98_RS03805	COG1073	alpha beta
I6N98_RS03810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6N98_RS03815	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS03820	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS03835	COG3268	Saccharopine dehydrogenase
I6N98_RS03860	COG0183	Belongs to the thiolase family
I6N98_RS03865	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS03895	COG0604	alcohol dehydrogenase
I6N98_RS03925	COG2267	carboxylic ester hydrolase activity
I6N98_RS03935	COG2314	TM2 domain
I6N98_RS03940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6N98_RS03945	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6N98_RS03965	COG2840	Smr protein MutS2
I6N98_RS03975	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6N98_RS03980	COG0154	amidase activity
I6N98_RS03985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6N98_RS03990	COG1077	Cell shape determining protein MreB Mrl
I6N98_RS03995	COG1792	Involved in formation and maintenance of cell shape
I6N98_RS04000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6N98_RS04005	COG0424	maF-like protein
I6N98_RS04010	COG1530	ribonuclease E activity
I6N98_RS04015	COG3164	Protein of unknown function
I6N98_RS04020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6N98_RS04030	COG2239	Acts as a magnesium transporter
I6N98_RS04040	COG1660	Displays ATPase and GTPase activities
I6N98_RS04060	COG1137	ATPase activity
I6N98_RS04065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6N98_RS04075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6N98_RS04090	COG5007	Belongs to the BolA IbaG family
I6N98_RS04095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6N98_RS04100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6N98_RS04115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6N98_RS04130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6N98_RS04135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6N98_RS04140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6N98_RS04145	COG0723	plastoquinol--plastocyanin reductase activity
I6N98_RS04150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6N98_RS04155	COG0625	glutathione transferase activity
I6N98_RS04160	COG2969	positive regulation of protein catabolic process
I6N98_RS04165	COG2823	Periplasmic or secreted lipoprotein
I6N98_RS04170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6N98_RS04175	COG0792	nuclease activity
I6N98_RS04180	COG3107	peptidoglycan biosynthetic process
I6N98_RS04195	COG2001	Belongs to the MraZ family
I6N98_RS04200	COG0275	rRNA processing
I6N98_RS04205	COG3116	cell division
I6N98_RS04215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6N98_RS04220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6N98_RS04225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6N98_RS04230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6N98_RS04235	COG0772	Belongs to the SEDS family
I6N98_RS04240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6N98_RS04245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6N98_RS04250	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6N98_RS04270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6N98_RS04275	COG0653	protein targeting
I6N98_RS04280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6N98_RS04285	COG0494	nUDIX hydrolase
I6N98_RS04325	COG0463	Glycosyl transferase, family 2
I6N98_RS04330	COG1132	(ABC) transporter
I6N98_RS04335	COG0438	transferase activity, transferring glycosyl groups
I6N98_RS04385	COG3725	Membrane protein required for beta-lactamase induction
I6N98_RS04390	COG1940	carbohydrate kinase activity
I6N98_RS04395	COG2096	Adenosyltransferase
I6N98_RS04440	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS04445	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS04450	COG1024	Enoyl-CoA hydratase
I6N98_RS04455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6N98_RS04465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6N98_RS04480	COG2766	serine protein kinase
I6N98_RS04485	COG2718	Belongs to the UPF0229 family
I6N98_RS04490	COG2719	SpoVR family
I6N98_RS04505	COG0302	gtp cyclohydrolase
I6N98_RS04510	COG2326	polyphosphate kinase activity
I6N98_RS04515	COG0596	Alpha beta hydrolase
I6N98_RS04520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS04560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS04565	COG0183	Belongs to the thiolase family
I6N98_RS04570	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS04580	COG0183	Belongs to the thiolase family
I6N98_RS04590	COG4771	TonB-dependent receptor
I6N98_RS04600	COG2909	trisaccharide binding
I6N98_RS04615	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6N98_RS04615	COG1024	Enoyl-CoA hydratase
I6N98_RS04625	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS04635	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS04640	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS04660	COG1575	Belongs to the MenA family. Type 1 subfamily
I6N98_RS04745	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS04750	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6N98_RS04810	COG3706	GGDEF domain
I6N98_RS04810	COG4251	negative regulation of phosphorylation
I6N98_RS04810	COG2203	Gaf domain
I6N98_RS04810	COG5001	Diguanylate cyclase
I6N98_RS04840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6N98_RS04845	COG2176	DNA-directed DNA polymerase activity
I6N98_RS04850	COG0517	IMP dehydrogenase activity
I6N98_RS04860	COG0596	Alpha beta hydrolase
I6N98_RS04880	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS04900	COG4771	TonB-dependent receptor
I6N98_RS04915	COG2207	Transcriptional regulator
I6N98_RS04935	COG0477	Major facilitator Superfamily
I6N98_RS04940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6N98_RS04945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6N98_RS04950	COG1845	cytochrome c oxidase, subunit III
I6N98_RS04955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6N98_RS04970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6N98_RS04995	COG3026	antisigma factor binding
I6N98_RS05000	COG3086	response to oxidative stress
I6N98_RS05005	COG0481	GTPase activity
I6N98_RS05010	COG0681	Belongs to the peptidase S26 family
I6N98_RS05020	COG0571	ribonuclease III activity
I6N98_RS05025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6N98_RS05040	COG5002	protein histidine kinase activity
I6N98_RS05040	COG2205	protein histidine kinase activity
I6N98_RS05040	COG0784	Response regulator, receiver
I6N98_RS05050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6N98_RS05055	COG3956	TIGRFAM MazG family protein
I6N98_RS05065	COG0563	adenylate kinase activity
I6N98_RS05070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6N98_RS05090	COG1968	undecaprenyl-diphosphatase activity
I6N98_RS05095	COG2084	Dehydrogenase
I6N98_RS05100	COG1362	aminopeptidase activity
I6N98_RS05105	COG1024	Enoyl-CoA hydratase
I6N98_RS05140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6N98_RS05145	COG0343	queuine tRNA-ribosyltransferase activity
I6N98_RS05150	COG3323	Protein of unknown function (DUF1653)
I6N98_RS05150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6N98_RS05165	COG4536	flavin adenine dinucleotide binding
I6N98_RS05175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6N98_RS05180	COG0228	four-way junction DNA binding
I6N98_RS05185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6N98_RS05195	COG0335	large ribosomal subunit rRNA binding
I6N98_RS05205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6N98_RS05220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6N98_RS05230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6N98_RS05235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6N98_RS05240	COG1570	exodeoxyribonuclease VII activity
I6N98_RS05250	COG0519	Catalyzes the synthesis of GMP from XMP
I6N98_RS05250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6N98_RS05255	COG2366	antibiotic biosynthetic process
I6N98_RS05260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6N98_RS05270	COG0019	diaminopimelate decarboxylase activity
I6N98_RS05320	COG0590	tRNA wobble adenosine to inosine editing
I6N98_RS05330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6N98_RS05335	COG0384	phenazine biosynthesis protein PhzF
I6N98_RS05340	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6N98_RS05355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6N98_RS05365	COG0504	CTP synthase activity
I6N98_RS05370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6N98_RS05375	COG0148	phosphopyruvate hydratase activity
I6N98_RS05380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6N98_RS05385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6N98_RS05395	COG0585	pseudouridine synthase activity
I6N98_RS05400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6N98_RS05420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6N98_RS05425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6N98_RS05435	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS05440	COG1309	transcriptional regulator
I6N98_RS05445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6N98_RS05485	COG4964	Belongs to the GSP D family
I6N98_RS05510	COG2137	regulation of response to DNA damage stimulus
I6N98_RS05520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6N98_RS05545	COG1252	NADH dehydrogenase
I6N98_RS05575	COG2010	Cytochrome c
I6N98_RS05590	COG3278	Belongs to the heme-copper respiratory oxidase family
I6N98_RS05600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6N98_RS05615	COG0427	acetyl-CoA hydrolase
I6N98_RS05620	COG1024	Enoyl-CoA hydratase
I6N98_RS05625	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS05630	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS05640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6N98_RS05645	COG5001	Diguanylate cyclase
I6N98_RS05645	COG3300	MHYT domain
I6N98_RS05700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6N98_RS05720	COG0302	gtp cyclohydrolase
I6N98_RS05725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6N98_RS05740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6N98_RS05745	COG1819	glycosyl
I6N98_RS05750	COG2977	Belongs to the P-Pant transferase superfamily
I6N98_RS05755	COG2124	cytochrome p450
I6N98_RS05785	COG1115	amino acid carrier protein
I6N98_RS05800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6N98_RS05805	COG0235	Class ii aldolase
I6N98_RS05810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6N98_RS05830	COG1704	LemA family
I6N98_RS05840	COG1595	DNA-templated transcription, initiation
I6N98_RS05845	COG3806	Anti-sigma factor
I6N98_RS05855	COG2226	methyltransferase
I6N98_RS05855	COG0596	Alpha beta hydrolase
I6N98_RS05855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6N98_RS05870	COG0730	response to heat
I6N98_RS05885	COG0358	DNA primase activity
I6N98_RS05895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6N98_RS05905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6N98_RS05910	COG0617	tRNA 3'-terminal CCA addition
I6N98_RS05915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6N98_RS05920	COG2967	ApaG domain
I6N98_RS05925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6N98_RS05930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6N98_RS05935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6N98_RS05940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6N98_RS05950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6N98_RS05955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6N98_RS05960	COG0546	phosphoglycolate phosphatase activity
I6N98_RS05995	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6N98_RS06000	COG0512	Glutamine amidotransferase of anthranilate synthase
I6N98_RS06005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6N98_RS06010	COG0134	indole-3-glycerol-phosphate synthase activity
I6N98_RS06020	COG1765	OsmC-like protein
I6N98_RS06030	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6N98_RS06035	COG2205	protein histidine kinase activity
I6N98_RS06035	COG0784	Response regulator, receiver
I6N98_RS06035	COG5002	protein histidine kinase activity
I6N98_RS06040	COG0151	Belongs to the GarS family
I6N98_RS06045	COG0138	bifunctional purine biosynthesis protein purh
I6N98_RS06065	COG2264	protein methyltransferase activity
I6N98_RS06075	COG0511	ligase activity, forming carbon-carbon bonds
I6N98_RS06080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6N98_RS06105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6N98_RS06110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6N98_RS06120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6N98_RS06125	COG1943	Transposase
I6N98_RS06130	COG2161	toxin-antitoxin pair type II binding
I6N98_RS06135	COG4115	mRNA cleavage
I6N98_RS06140	COG1119	ATPase activity
I6N98_RS06145	COG0489	protein tyrosine kinase activity
I6N98_RS06145	COG3206	protein involved in exopolysaccharide biosynthesis
I6N98_RS06190	COG0438	transferase activity, transferring glycosyl groups
I6N98_RS06260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6N98_RS06270	COG1278	Cold shock
I6N98_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS06285	COG1063	alcohol dehydrogenase
I6N98_RS06295	COG2814	Major facilitator Superfamily
I6N98_RS06300	COG0183	Belongs to the thiolase family
I6N98_RS06305	COG1309	transcriptional regulator
I6N98_RS06325	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS06360	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS06370	COG0385	Bile acid
I6N98_RS06375	COG0492	ferredoxin-NADP+ reductase activity
I6N98_RS06390	COG0657	acetylesterase activity
I6N98_RS06410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6N98_RS06415	COG0022	dehydrogenase e1 component
I6N98_RS06430	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS06445	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS06455	COG3383	formate dehydrogenase (NAD+) activity
I6N98_RS06460	COG4774	siderophore transport
I6N98_RS06505	COG2124	cytochrome p450
I6N98_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS06515	COG4771	TonB-dependent receptor
I6N98_RS06520	COG1053	succinate dehydrogenase
I6N98_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS06530	COG0625	glutathione transferase activity
I6N98_RS06550	COG0243	molybdopterin cofactor binding
I6N98_RS06565	COG2271	Major facilitator Superfamily
I6N98_RS06585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6N98_RS06590	COG4638	Rieske (2fe-2S)
I6N98_RS06605	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS06610	COG0667	Aldo Keto reductase
I6N98_RS06635	COG4774	siderophore transport
I6N98_RS06650	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06655	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06660	COG1024	Enoyl-CoA hydratase
I6N98_RS06665	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS06690	COG1024	Enoyl-CoA hydratase
I6N98_RS06700	COG1088	dTDP-glucose 4,6-dehydratase activity
I6N98_RS06735	COG1024	Enoyl-CoA hydratase
I6N98_RS06745	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06755	COG0604	alcohol dehydrogenase
I6N98_RS06770	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS06775	COG2124	cytochrome p450
I6N98_RS06795	COG4771	TonB-dependent receptor
I6N98_RS06805	COG0281	malic enzyme
I6N98_RS06825	COG0697	spore germination
I6N98_RS06830	COG0850	regulation of cytokinetic process
I6N98_RS06835	COG2894	cell division
I6N98_RS06840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6N98_RS06845	COG0280	phosphate acetyltransferase
I6N98_RS06885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6N98_RS06905	COG0686	Belongs to the AlaDH PNT family
I6N98_RS06950	COG1024	Enoyl-CoA hydratase
I6N98_RS06955	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06960	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06965	COG0183	Belongs to the thiolase family
I6N98_RS06980	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06985	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS06995	COG0183	Belongs to the thiolase family
I6N98_RS07015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6N98_RS07025	COG2853	Lipoprotein
I6N98_RS07030	COG2204	response regulator
I6N98_RS07045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6N98_RS07050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6N98_RS07055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6N98_RS07090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6N98_RS07095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6N98_RS07105	COG3100	YcgL domain-containing protein
I6N98_RS07110	COG2983	Belongs to the UPF0260 family
I6N98_RS07135	COG4191	Histidine kinase
I6N98_RS07135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N98_RS07180	COG0778	Nitroreductase
I6N98_RS07185	COG1024	Enoyl-CoA hydratase
I6N98_RS07200	COG0720	synthase
I6N98_RS07230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6N98_RS07235	COG0705	Rhomboid family
I6N98_RS07240	COG3139	Protein of unknown function (DUF1315)
I6N98_RS07250	COG0308	aminopeptidase N
I6N98_RS07255	COG0175	sulfate reduction
I6N98_RS07260	COG0167	dihydroorotate dehydrogenase activity
I6N98_RS07275	COG4191	Histidine kinase
I6N98_RS07275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N98_RS07280	COG0784	Response regulator, receiver
I6N98_RS07280	COG3437	response regulator, receiver
I6N98_RS07285	COG3437	response regulator, receiver
I6N98_RS07285	COG0784	Response regulator, receiver
I6N98_RS07290	COG5001	Diguanylate cyclase
I6N98_RS07290	COG5002	protein histidine kinase activity
I6N98_RS07320	COG3706	GGDEF domain
I6N98_RS07320	COG5001	Diguanylate cyclase
I6N98_RS07320	COG4251	negative regulation of phosphorylation
I6N98_RS07320	COG2203	Gaf domain
I6N98_RS07325	COG2132	Multicopper oxidase
I6N98_RS07350	COG4773	Receptor
I6N98_RS07360	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS07370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6N98_RS07385	COG0583	DNA-binding transcription factor activity
I6N98_RS07390	COG0529	Catalyzes the synthesis of activated sulfate
I6N98_RS07395	COG2046	Belongs to the sulfate adenylyltransferase family
I6N98_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS07420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6N98_RS07435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6N98_RS07435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6N98_RS07455	COG0657	acetylesterase activity
I6N98_RS07470	COG2835	tetraacyldisaccharide 4'-kinase activity
I6N98_RS07475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6N98_RS07480	COG0527	aspartate kinase activity
I6N98_RS07485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6N98_RS07520	COG3177	Filamentation induced by cAMP protein fic
I6N98_RS07525	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6N98_RS07530	COG2003	Belongs to the UPF0758 family
I6N98_RS07550	COG0582	viral genome integration into host DNA
I6N98_RS07560	COG0784	Response regulator, receiver
I6N98_RS07565	COG4251	negative regulation of phosphorylation
I6N98_RS07570	COG2205	protein histidine kinase activity
I6N98_RS07580	COG0456	acetyltransferase
I6N98_RS07580	COG1214	PFAM Peptidase M22, glycoprotease
I6N98_RS07585	COG0189	ligase activity
I6N98_RS07600	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6N98_RS07610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6N98_RS07615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6N98_RS07625	COG1136	(ABC) transporter
I6N98_RS07625	COG0577	efflux transmembrane transporter activity
I6N98_RS07630	COG0577	efflux transmembrane transporter activity
I6N98_RS07630	COG1136	(ABC) transporter
I6N98_RS07635	COG0577	efflux transmembrane transporter activity
I6N98_RS07635	COG1136	(ABC) transporter
I6N98_RS07640	COG0484	heat shock protein binding
I6N98_RS07645	COG0789	Transcriptional regulator
I6N98_RS07680	COG1558	bacterial-type flagellum-dependent cell motility
I6N98_RS07685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6N98_RS07695	COG4787	bacterial-type flagellum-dependent cell motility
I6N98_RS07705	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6N98_RS07725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6N98_RS07740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6N98_RS07785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6N98_RS07840	COG1684	flagellar biosynthetic protein fliR
I6N98_RS07875	COG2902	Dehydrogenase
I6N98_RS07880	COG0657	acetylesterase activity
I6N98_RS07890	COG2133	pyrroloquinoline quinone binding
I6N98_RS07900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6N98_RS07905	COG1393	Belongs to the ArsC family
I6N98_RS07920	COG0616	signal peptide processing
I6N98_RS07925	COG1858	cytochrome C peroxidase
I6N98_RS07935	COG2010	Cytochrome c
I6N98_RS07950	COG1566	PFAM secretion protein HlyD family protein
I6N98_RS07955	COG3008	intermembrane lipid transfer
I6N98_RS07960	COG2995	paraquat-inducible protein a
I6N98_RS07970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6N98_RS07985	COG1272	protein, Hemolysin III
I6N98_RS08005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6N98_RS08015	COG0386	Belongs to the glutathione peroxidase family
I6N98_RS08045	COG1116	anion transmembrane transporter activity
I6N98_RS08045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6N98_RS08050	COG1116	anion transmembrane transporter activity
I6N98_RS08060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6N98_RS08060	COG1116	anion transmembrane transporter activity
I6N98_RS08065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N98_RS08070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6N98_RS08075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6N98_RS08080	COG0215	cysteine-tRNA ligase activity
I6N98_RS08095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6N98_RS08130	COG2350	Protein conserved in bacteria
I6N98_RS08140	COG0613	PHP domain protein
I6N98_RS08145	COG0009	L-threonylcarbamoyladenylate synthase
I6N98_RS08150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6N98_RS08155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6N98_RS08160	COG1187	pseudouridine synthase activity
I6N98_RS08165	COG3130	regulation of translation
I6N98_RS08170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6N98_RS08170	COG0116	Belongs to the methyltransferase superfamily
I6N98_RS08195	COG0788	formyltetrahydrofolate deformylase activity
I6N98_RS08215	COG0573	inorganic phosphate transmembrane transporter activity
I6N98_RS08220	COG0581	inorganic phosphate transmembrane transporter activity
I6N98_RS08230	COG0704	Plays a role in the regulation of phosphate uptake
I6N98_RS08235	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6N98_RS08260	COG1444	tRNA N-acetyltransferase activity
I6N98_RS08310	COG2009	succinate dehydrogenase
I6N98_RS08320	COG1053	succinate dehydrogenase
I6N98_RS08325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6N98_RS08355	COG1309	transcriptional regulator
I6N98_RS08360	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS08365	COG0326	Molecular chaperone. Has ATPase activity
I6N98_RS08370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6N98_RS08385	COG2890	protein-(glutamine-N5) methyltransferase activity
I6N98_RS08390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6N98_RS08395	COG2814	Major facilitator Superfamily
I6N98_RS08415	COG0011	TIGRFAM Protein of
I6N98_RS08440	COG3101	peptidyl-lysine hydroxylation
I6N98_RS08445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6N98_RS08445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6N98_RS08450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6N98_RS08460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6N98_RS08460	COG0116	Belongs to the methyltransferase superfamily
I6N98_RS08465	COG0436	Aminotransferase
I6N98_RS08470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6N98_RS08495	COG1131	(ABC) transporter
I6N98_RS08500	COG0842	Transport permease protein
I6N98_RS08505	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6N98_RS08505	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6N98_RS08525	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6N98_RS08530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6N98_RS08535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6N98_RS08550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6N98_RS08555	COG0670	Belongs to the BI1 family
I6N98_RS08565	COG1530	ribonuclease E activity
I6N98_RS08580	COG0424	maF-like protein
I6N98_RS08590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6N98_RS08595	COG0416	fatty acid biosynthetic process
I6N98_RS08610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6N98_RS08615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6N98_RS08625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6N98_RS08630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6N98_RS08645	COG0084	hydrolase, TatD family'
I6N98_RS08650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6N98_RS08655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6N98_RS08655	COG3291	Pkd domain containing protein
I6N98_RS08660	COG1024	Enoyl-CoA hydratase
I6N98_RS08660	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6N98_RS08665	COG0183	Belongs to the thiolase family
I6N98_RS08675	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6N98_RS08680	COG0740	serine-type endopeptidase activity
I6N98_RS08685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6N98_RS08690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6N98_RS08700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6N98_RS08705	COG2091	lysine biosynthetic process via aminoadipic acid
I6N98_RS08710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6N98_RS08750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6N98_RS08765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6N98_RS08765	COG0316	Belongs to the HesB IscA family
I6N98_RS08770	COG3568	Endonuclease Exonuclease Phosphatase
I6N98_RS08775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6N98_RS08785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6N98_RS08795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6N98_RS08800	COG2813	Specifically methylates the guanine in position
I6N98_RS08805	COG2365	Tyrosine phosphatase family
I6N98_RS08810	COG4753	response regulator
I6N98_RS08810	COG2207	Transcriptional regulator
I6N98_RS08815	COG4608	Belongs to the ABC transporter superfamily
I6N98_RS08820	COG0444	Belongs to the ABC transporter superfamily
I6N98_RS08830	COG4239	(ABC) transporter, permease
I6N98_RS08835	COG4174	ABC transporter (Permease)
I6N98_RS08840	COG1388	LysM domain
I6N98_RS08840	COG0741	lytic transglycosylase activity
I6N98_RS08855	COG0328	RNA-DNA hybrid ribonuclease activity
I6N98_RS08860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6N98_RS08875	COG0616	signal peptide processing
I6N98_RS08900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N98_RS08920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6N98_RS08940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6N98_RS08985	COG1309	transcriptional regulator
I6N98_RS08990	COG2050	protein possibly involved in aromatic compounds catabolism
I6N98_RS09020	COG4771	TonB-dependent receptor
I6N98_RS09030	COG0183	Belongs to the thiolase family
I6N98_RS09050	COG4771	TonB-dependent receptor
I6N98_RS09060	COG2124	cytochrome p450
I6N98_RS09065	COG0431	NADPH-dependent FMN reductase
I6N98_RS09065	COG1053	succinate dehydrogenase
I6N98_RS09065	COG3976	FMN-binding domain protein
I6N98_RS09075	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS09090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6N98_RS09095	COG0022	dehydrogenase e1 component
I6N98_RS09105	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6N98_RS09110	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS09115	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS09125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N98_RS09140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N98_RS09145	COG2130	NADP-dependent
I6N98_RS09155	COG4372	Transposase
I6N98_RS09175	COG0656	L-ascorbic acid biosynthetic process
I6N98_RS09220	COG0793	Belongs to the peptidase S41A family
I6N98_RS09230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6N98_RS09230	COG1648	precorrin-2 dehydrogenase activity
I6N98_RS09235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6N98_RS09245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6N98_RS09250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6N98_RS09260	COG0492	ferredoxin-NADP+ reductase activity
I6N98_RS09265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6N98_RS09270	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6N98_RS09275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6N98_RS09280	COG0542	response to heat
I6N98_RS09290	COG1278	Cold shock
I6N98_RS09300	COG1187	pseudouridine synthase activity
I6N98_RS09315	COG2915	High frequency lysogenization protein hflD homolog
I6N98_RS09325	COG2850	peptidyl-arginine hydroxylation
I6N98_RS09345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6N98_RS09370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6N98_RS09375	COG2853	Lipoprotein
I6N98_RS09395	COG0456	acetyltransferase
I6N98_RS09400	COG1703	isobutyryl-CoA mutase activity
I6N98_RS09405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6N98_RS09405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6N98_RS09410	COG0346	lactoylglutathione lyase activity
I6N98_RS09415	COG0439	Biotin carboxylase
I6N98_RS09420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6N98_RS09425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6N98_RS09435	COG0560	Phosphoserine phosphatase
I6N98_RS09455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6N98_RS09460	COG1115	amino acid carrier protein
I6N98_RS09465	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6N98_RS09470	COG1862	Preprotein translocase
I6N98_RS09495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6N98_RS09500	COG1322	Protein conserved in bacteria
I6N98_RS09520	COG0314	molybdopterin synthase activity
I6N98_RS09525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6N98_RS09530	COG0315	cyclic pyranopterin monophosphate synthase activity
I6N98_RS09535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6N98_RS09550	COG2974	May be involved in recombination
I6N98_RS09570	COG0537	adenosine 5'-monophosphoramidase activity
I6N98_RS09575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6N98_RS09630	COG0789	Transcriptional regulator
I6N98_RS09665	COG0347	Belongs to the P(II) protein family
I6N98_RS09685	COG0789	Transcriptional regulator
I6N98_RS09700	COG5002	protein histidine kinase activity
I6N98_RS09705	COG0745	RESPONSE REGULATOR receiver
I6N98_RS09775	COG2217	Heavy metal translocating P-type atpase
I6N98_RS09785	COG0789	Transcriptional regulator
I6N98_RS09790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N98_RS09795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N98_RS09885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6N98_RS09890	COG0322	excinuclease ABC activity
I6N98_RS09910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6N98_RS09915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6N98_RS09920	COG1663	tetraacyldisaccharide 4'-kinase activity
I6N98_RS09925	COG1132	(ABC) transporter
I6N98_RS09935	COG0811	peptide transport
I6N98_RS09950	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6N98_RS09965	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6N98_RS09965	COG1605	Chorismate mutase
I6N98_RS09975	COG1477	protein flavinylation
I6N98_RS09980	COG2871	sodium ion transport
I6N98_RS09985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6N98_RS10000	COG1805	sodium ion transport
I6N98_RS10005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6N98_RS10015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6N98_RS10025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6N98_RS10030	COG0668	transmembrane transport
I6N98_RS10040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6N98_RS10075	COG0589	response to stress
I6N98_RS10080	COG0488	(ABC) transporter
I6N98_RS10085	COG0741	lytic transglycosylase activity
I6N98_RS10090	COG0633	Ferredoxin
I6N98_RS10090	COG3217	Mosc domain protein beta barrel domain protein
I6N98_RS10100	COG0004	ammonium transporteR
I6N98_RS10105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6N98_RS10115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6N98_RS10120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6N98_RS10125	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N98_RS10130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N98_RS10135	COG1309	transcriptional regulator
I6N98_RS10165	COG0714	Associated with various cellular activities
I6N98_RS10180	COG1286	toxin biosynthetic process
I6N98_RS10190	COG0285	dihydrofolate synthase activity
I6N98_RS10195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6N98_RS10200	COG0159	tryptophan synthase activity
I6N98_RS10205	COG0133	tryptophan synthase activity
I6N98_RS10210	COG0135	phosphoribosylanthranilate isomerase activity
I6N98_RS10225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6N98_RS10235	COG0473	3-isopropylmalate dehydrogenase activity
I6N98_RS10240	COG0066	3-isopropylmalate dehydratase activity
I6N98_RS10245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6N98_RS10260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6N98_RS10275	COG0346	lactoylglutathione lyase activity
I6N98_RS10285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6N98_RS10290	COG3115	cell septum assembly
I6N98_RS10310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6N98_RS10315	COG1138	Cytochrome C-type biogenesis protein
I6N98_RS10320	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6N98_RS10340	COG4133	protoheme IX ABC transporter activity
I6N98_RS10380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6N98_RS10385	COG0037	tRNA processing
I6N98_RS10390	COG0039	L-malate dehydrogenase activity
I6N98_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS10410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6N98_RS10415	COG4181	ATPase activity
I6N98_RS10430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6N98_RS10435	COG0432	Pfam Uncharacterised protein family UPF0047
I6N98_RS10450	COG0564	pseudouridine synthase activity
I6N98_RS10460	COG0596	Alpha beta hydrolase
I6N98_RS10480	COG0625	glutathione transferase activity
I6N98_RS10505	COG2885	chlorophyll binding
I6N98_RS10525	COG0776	regulation of translation
I6N98_RS10530	COG0072	phenylalanine-tRNA ligase activity
I6N98_RS10530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6N98_RS10535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6N98_RS10540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6N98_RS10545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6N98_RS10550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6N98_RS10555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6N98_RS10565	COG0556	nucleotide-excision repair
I6N98_RS10580	COG3273	potassium ion transport
I6N98_RS10580	COG0471	metal ion transport
I6N98_RS10590	COG0284	orotidine-5'-phosphate decarboxylase activity
I6N98_RS10595	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6N98_RS10605	COG0776	regulation of translation
I6N98_RS10615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6N98_RS10620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6N98_RS10625	COG0287	Prephenate dehydrogenase
I6N98_RS10630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6N98_RS10635	COG1605	Chorismate mutase
I6N98_RS10635	COG0077	Prephenate dehydratase
I6N98_RS10640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6N98_RS10650	COG0402	S-adenosylhomocysteine deaminase activity
I6N98_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS10670	COG0742	ribosomal rna small subunit methyltransferase
I6N98_RS10690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6N98_RS10695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6N98_RS10705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6N98_RS10725	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6N98_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS10740	COG0469	pyruvate kinase activity
I6N98_RS10765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6N98_RS10765	COG2169	Transcriptional regulator
I6N98_RS10775	COG3040	lipid binding
I6N98_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS10845	COG2308	Evidence 4 Homologs of previously reported genes of
I6N98_RS10860	COG1025	Belongs to the peptidase M16 family
I6N98_RS10870	COG0425	Belongs to the sulfur carrier protein TusA family
I6N98_RS10880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6N98_RS10890	COG0800	Aldolase
I6N98_RS10900	COG2207	Transcriptional regulator
I6N98_RS10910	COG0183	Belongs to the thiolase family
I6N98_RS10915	COG1024	Enoyl-CoA hydratase
I6N98_RS10955	COG0243	molybdopterin cofactor binding
I6N98_RS10990	COG2165	general secretion pathway protein
I6N98_RS11000	COG2165	general secretion pathway protein
I6N98_RS11005	COG1459	type II secretion system
I6N98_RS11010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6N98_RS11020	COG3031	protein transport across the cell outer membrane
I6N98_RS11030	COG1773	rubredoxin
I6N98_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS11060	COG1054	Belongs to the UPF0176 family
I6N98_RS11065	COG0271	Belongs to the BolA IbaG family
I6N98_RS11080	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6N98_RS11115	COG2200	EAL domain
I6N98_RS11120	COG1024	Enoyl-CoA hydratase
I6N98_RS11120	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6N98_RS11125	COG0183	Belongs to the thiolase family
I6N98_RS11130	COG4753	response regulator
I6N98_RS11130	COG2207	Transcriptional regulator
I6N98_RS11140	COG0642	Histidine kinase
I6N98_RS11145	COG0745	RESPONSE REGULATOR receiver
I6N98_RS11160	COG0795	lipopolysaccharide-transporting ATPase activity
I6N98_RS11165	COG0795	lipopolysaccharide-transporting ATPase activity
I6N98_RS11170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6N98_RS11185	COG0525	valine-tRNA ligase activity
I6N98_RS11190	COG1278	Cold shock
I6N98_RS11195	COG2205	protein histidine kinase activity
I6N98_RS11195	COG0784	Response regulator, receiver
I6N98_RS11195	COG5002	protein histidine kinase activity
I6N98_RS11205	COG2900	Belongs to the SlyX family
I6N98_RS11210	COG0023	Translation Initiation Factor
I6N98_RS11225	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6N98_RS11240	COG1192	Involved in chromosome partitioning
I6N98_RS11245	COG2954	triphosphatase activity
I6N98_RS11255	COG0439	Biotin carboxylase
I6N98_RS11260	COG0583	DNA-binding transcription factor activity
I6N98_RS11265	COG2264	protein methyltransferase activity
I6N98_RS11275	COG0564	pseudouridine synthase activity
I6N98_RS11295	COG0531	amino acid
I6N98_RS11300	COG0628	permease
I6N98_RS11305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6N98_RS11310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6N98_RS11325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6N98_RS11325	COG3153	acetyltransferase
I6N98_RS11330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6N98_RS11335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6N98_RS11340	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6N98_RS11345	COG2885	chlorophyll binding
I6N98_RS11370	COG0484	heat shock protein binding
I6N98_RS11380	COG0501	Belongs to the peptidase M48B family
I6N98_RS11395	COG1643	Atp-dependent helicase
I6N98_RS11425	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS11430	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS11455	COG0004	ammonium transporteR
I6N98_RS11470	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS11480	COG0363	glucosamine-6-phosphate deaminase activity
I6N98_RS11485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6N98_RS11530	COG0028	Belongs to the TPP enzyme family
I6N98_RS11580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6N98_RS11580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6N98_RS11660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6N98_RS11665	COG1047	Peptidyl-prolyl cis-trans
I6N98_RS11670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6N98_RS11675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6N98_RS11680	COG0196	riboflavin kinase activity
I6N98_RS11685	COG0728	peptidoglycan biosynthetic process
I6N98_RS11690	COG0494	nUDIX hydrolase
I6N98_RS11695	COG0540	Belongs to the ATCase OTCase family
I6N98_RS11705	COG2827	Endonuclease containing a URI domain
I6N98_RS11710	COG2925	Exonuclease
I6N98_RS11715	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6N98_RS11715	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6N98_RS11755	COG1902	pentaerythritol trinitrate reductase activity
I6N98_RS11760	COG0459	protein refolding
I6N98_RS11765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6N98_RS11780	COG0288	reversible hydration of carbon dioxide
I6N98_RS11810	COG1666	GTP binding
I6N98_RS11835	COG3239	Fatty acid desaturase
I6N98_RS11845	COG4206	TonB-dependent receptor
I6N98_RS11860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6N98_RS11865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N98_RS11870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6N98_RS11875	COG0778	Nitroreductase
I6N98_RS11880	COG1492	cobalamin metabolic process
I6N98_RS11885	COG3437	response regulator, receiver
I6N98_RS11885	COG0784	Response regulator, receiver
I6N98_RS11890	COG4191	Histidine kinase
I6N98_RS11905	COG0587	DNA-directed DNA polymerase activity
I6N98_RS11910	COG0514	ATP-dependent DNA helicase (RecQ)
I6N98_RS11925	COG0071	Belongs to the small heat shock protein (HSP20) family
I6N98_RS11935	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6N98_RS11945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6N98_RS11985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6N98_RS12030	COG2130	NADP-dependent
I6N98_RS12035	COG0596	Alpha beta hydrolase
I6N98_RS12045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6N98_RS12065	COG1024	Enoyl-CoA hydratase
I6N98_RS12070	COG0778	Nitroreductase
I6N98_RS12075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS12080	COG1024	Enoyl-CoA hydratase
I6N98_RS12105	COG2832	Protein of unknown function (DUF454)
I6N98_RS12130	COG1160	GTP binding
I6N98_RS12140	COG2976	Protein conserved in bacteria
I6N98_RS12145	COG0124	histidyl-tRNA synthetase
I6N98_RS12150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6N98_RS12165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6N98_RS12170	COG0105	UTP biosynthetic process
I6N98_RS12190	COG2166	iron-sulfur cluster assembly
I6N98_RS12200	COG0316	Belongs to the HesB IscA family
I6N98_RS12205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6N98_RS12210	COG0719	Fe-S assembly protein
I6N98_RS12215	COG0396	ATPase activity
I6N98_RS12220	COG0719	Fe-S assembly protein
I6N98_RS12230	COG0825	malonyl-CoA metabolic process
I6N98_RS12240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6N98_RS12245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N98_RS12250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N98_RS12255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6N98_RS12260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N98_RS12280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6N98_RS12295	COG0233	cytoplasmic translational termination
I6N98_RS12300	COG0528	UMP kinase activity
I6N98_RS12305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6N98_RS12310	COG0052	Belongs to the universal ribosomal protein uS2 family
I6N98_RS12315	COG0024	Methionine aminopeptidase
I6N98_RS12325	COG0436	Aminotransferase
I6N98_RS12330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6N98_RS12335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6N98_RS12340	COG1393	Belongs to the ArsC family
I6N98_RS12350	COG0604	alcohol dehydrogenase
I6N98_RS12355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6N98_RS12370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6N98_RS12380	COG4681	YaeQ
I6N98_RS12390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6N98_RS12395	COG0714	Associated with various cellular activities
I6N98_RS12415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6N98_RS12420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6N98_RS12425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS12440	COG0783	Belongs to the Dps family
I6N98_RS12480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6N98_RS12485	COG2264	protein methyltransferase activity
I6N98_RS12515	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N98_RS12525	COG3220	belongs to the UPF0276 family
I6N98_RS12535	COG1643	Atp-dependent helicase
I6N98_RS12550	COG0444	Belongs to the ABC transporter superfamily
I6N98_RS12555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N98_RS12560	COG0601	transmembrane transport
I6N98_RS12565	COG4166	transmembrane transport
I6N98_RS12570	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6N98_RS12570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6N98_RS12610	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS12625	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS12630	COG1053	succinate dehydrogenase
I6N98_RS12635	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS12640	COG0300	oxidoreductase activity
I6N98_RS12655	COG2072	flavoprotein involved in K transport
I6N98_RS12665	COG2144	transferase activity, transferring acyl groups
I6N98_RS12690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6N98_RS12705	COG2175	clavaminate synthase activity
I6N98_RS12710	COG1053	succinate dehydrogenase
I6N98_RS12735	COG1053	succinate dehydrogenase
I6N98_RS12750	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS12760	COG2124	cytochrome p450
I6N98_RS12765	COG0633	Ferredoxin
I6N98_RS12775	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS12780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6N98_RS12785	COG4770	biotin carboxylase activity
I6N98_RS12790	COG1024	Enoyl-CoA hydratase
I6N98_RS12815	COG2188	Transcriptional regulator
I6N98_RS12820	COG4638	Rieske (2fe-2S)
I6N98_RS12830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS12845	COG4774	siderophore transport
I6N98_RS12850	COG4638	Rieske (2fe-2S)
I6N98_RS12870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6N98_RS12870	COG2010	Cytochrome c
I6N98_RS12895	COG0642	Histidine kinase
I6N98_RS12925	COG3245	cytochrome
I6N98_RS12980	COG0028	Belongs to the TPP enzyme family
I6N98_RS12985	COG4638	Rieske (2fe-2S)
I6N98_RS12990	COG2072	flavoprotein involved in K transport
I6N98_RS13025	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS13055	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS13060	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS13070	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS13075	COG4067	protein conserved in archaea
I6N98_RS13075	COG0189	ligase activity
I6N98_RS13090	COG0582	viral genome integration into host DNA
I6N98_RS13120	COG4774	siderophore transport
I6N98_RS13140	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS13175	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS13185	COG2186	Transcriptional regulator
I6N98_RS13190	COG0318	PFAM AMP-dependent synthetase and ligase
I6N98_RS13195	COG1024	Enoyl-CoA hydratase
I6N98_RS13205	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS13255	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS13285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6N98_RS13295	COG1024	Enoyl-CoA hydratase
I6N98_RS13300	COG0183	Belongs to the thiolase family
I6N98_RS13305	COG1024	Enoyl-CoA hydratase
I6N98_RS13305	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6N98_RS13310	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS13350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS13355	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS13360	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS13365	COG2070	2-Nitropropane dioxygenase
I6N98_RS13375	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS13380	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS13390	COG2814	Major facilitator Superfamily
I6N98_RS13410	COG0210	DNA helicase
I6N98_RS13435	COG2860	membrane
I6N98_RS13445	COG0300	oxidoreductase activity
I6N98_RS13450	COG4771	TonB-dependent receptor
I6N98_RS13460	COG1309	transcriptional regulator
I6N98_RS13505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6N98_RS13505	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6N98_RS13525	COG0739	heme binding
I6N98_RS13530	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6N98_RS13550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6N98_RS13560	COG0714	Associated with various cellular activities
I6N98_RS13580	COG2304	oxidoreductase activity
I6N98_RS13610	COG4251	negative regulation of phosphorylation
I6N98_RS13630	COG4191	Histidine kinase
I6N98_RS13640	COG4566	intracellular signal transduction
I6N98_RS13650	COG3098	single-species biofilm formation
I6N98_RS13655	COG1199	ATP-dependent helicase activity
I6N98_RS13685	COG0582	viral genome integration into host DNA
I6N98_RS13770	COG4447	cellulose binding
I6N98_RS13785	COG2130	NADP-dependent
I6N98_RS13790	COG2207	Transcriptional regulator
I6N98_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS13815	COG0183	Belongs to the thiolase family
I6N98_RS13830	COG1959	2 iron, 2 sulfur cluster binding
I6N98_RS13840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6N98_RS13850	COG1773	rubredoxin
I6N98_RS13855	COG1773	rubredoxin
I6N98_RS13870	COG2050	protein possibly involved in aromatic compounds catabolism
I6N98_RS13875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6N98_RS13880	COG2151	metal-sulfur cluster biosynthetic enzyme
I6N98_RS13885	COG3396	Phenylacetate-CoA oxygenase
I6N98_RS13890	COG3460	Phenylacetate-CoA oxygenase
I6N98_RS13895	COG3396	Phenylacetate-CoA oxygenase
I6N98_RS13900	COG0183	Belongs to the thiolase family
I6N98_RS13905	COG1024	Enoyl-CoA hydratase
I6N98_RS13910	COG2030	dehydratase
I6N98_RS13910	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS13915	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6N98_RS13915	COG1024	Enoyl-CoA hydratase
I6N98_RS13940	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6N98_RS13985	COG0583	DNA-binding transcription factor activity
I6N98_RS14015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6N98_RS14020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6N98_RS14040	COG4771	TonB-dependent receptor
I6N98_RS14060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6N98_RS14065	COG0523	cobalamin synthesis protein
I6N98_RS14095	COG0589	response to stress
I6N98_RS14100	COG0659	secondary active sulfate transmembrane transporter activity
I6N98_RS14115	COG0438	transferase activity, transferring glycosyl groups
I6N98_RS14145	COG1560	Kdo2-lipid A biosynthetic process
I6N98_RS14150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6N98_RS14155	COG0268	Binds directly to 16S ribosomal RNA
I6N98_RS14160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6N98_RS14165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6N98_RS14175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6N98_RS14180	COG0142	geranyltranstransferase activity
I6N98_RS14185	COG0166	Belongs to the GPI family
I6N98_RS14200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6N98_RS14210	COG0303	'Molybdopterin
I6N98_RS14215	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6N98_RS14230	COG2814	Major facilitator Superfamily
I6N98_RS14240	COG0203	ribosomal protein L17
I6N98_RS14245	COG0202	RNA polymerase activity
I6N98_RS14250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6N98_RS14255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6N98_RS14260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6N98_RS14265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6N98_RS14275	COG0200	Binds to the 23S rRNA
I6N98_RS14280	COG1841	ribosomal large subunit assembly
I6N98_RS14285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6N98_RS14290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6N98_RS14295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6N98_RS14300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6N98_RS14305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6N98_RS14310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6N98_RS14315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6N98_RS14320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6N98_RS14325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6N98_RS14335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6N98_RS14340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6N98_RS14345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6N98_RS14350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6N98_RS14355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6N98_RS14360	COG0089	rRNA binding
I6N98_RS14365	COG0088	Forms part of the polypeptide exit tunnel
I6N98_RS14370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6N98_RS14375	COG0051	transcription antitermination factor activity, RNA binding
I6N98_RS14380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6N98_RS14385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6N98_RS14390	COG0049	tRNA binding
I6N98_RS14395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6N98_RS14400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6N98_RS14405	COG0085	RNA polymerase activity
I6N98_RS14410	COG0222	ribosome binding
I6N98_RS14415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6N98_RS14420	COG0081	regulation of translation
I6N98_RS14425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6N98_RS14445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6N98_RS14510	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6N98_RS14520	COG1183	phosphatidylcholine synthase activity
I6N98_RS14530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6N98_RS14540	COG1454	alcohol dehydrogenase
I6N98_RS14545	COG0824	Thioesterase
I6N98_RS14550	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6N98_RS14555	COG0022	dehydrogenase e1 component
I6N98_RS14560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6N98_RS14595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6N98_RS14600	COG0602	queuosine metabolic process
I6N98_RS14605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6N98_RS14610	COG2885	chlorophyll binding
I6N98_RS14615	COG0823	Involved in the tonB-independent uptake of proteins
I6N98_RS14635	COG0824	Thioesterase
I6N98_RS14640	COG2255	four-way junction helicase activity
I6N98_RS14650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6N98_RS14660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6N98_RS14675	COG0579	oxidoreductase
I6N98_RS14685	COG0442	prolyl-tRNA aminoacylation
I6N98_RS14705	COG1595	DNA-templated transcription, initiation
I6N98_RS14725	COG4221	oxidoreductase activity
I6N98_RS14730	COG4221	oxidoreductase activity
I6N98_RS14750	COG0668	transmembrane transport
I6N98_RS14760	COG0366	Alpha amylase catalytic
I6N98_RS14780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6N98_RS14780	COG4651	solute:proton antiporter activity
I6N98_RS14785	COG1053	succinate dehydrogenase
I6N98_RS14785	COG3976	FMN-binding domain protein
I6N98_RS14795	COG1053	succinate dehydrogenase
I6N98_RS14805	COG0437	4 iron, 4 sulfur cluster binding
I6N98_RS14810	COG0243	molybdopterin cofactor binding
I6N98_RS14820	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6N98_RS14825	COG0628	permease
I6N98_RS14835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6N98_RS14840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6N98_RS14850	COG0717	Belongs to the dCTP deaminase family
I6N98_RS14855	COG0489	protein tyrosine kinase activity
I6N98_RS14865	COG4657	Part of a membrane complex involved in electron transport
I6N98_RS14870	COG2878	Part of a membrane complex involved in electron transport
I6N98_RS14875	COG4656	Part of a membrane complex involved in electron transport
I6N98_RS14880	COG4658	electron transport chain
I6N98_RS14885	COG4659	FMN binding
I6N98_RS14890	COG4660	Part of a membrane complex involved in electron transport
I6N98_RS14895	COG1686	Belongs to the peptidase S11 family
I6N98_RS14905	COG0456	acetyltransferase
I6N98_RS14915	COG3608	succinylglutamate desuccinylase aspartoacylase
I6N98_RS14925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6N98_RS14950	COG2304	oxidoreductase activity
I6N98_RS14970	COG0439	Biotin carboxylase
I6N98_RS14985	COG1116	anion transmembrane transporter activity
I6N98_RS15020	COG2890	protein-(glutamine-N5) methyltransferase activity
I6N98_RS15025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6N98_RS15030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6N98_RS15050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6N98_RS15060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6N98_RS15065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6N98_RS15070	COG0193	aminoacyl-tRNA hydrolase activity
I6N98_RS15075	COG0012	GTP binding
I6N98_RS15090	COG4106	trans-aconitate 2-methyltransferase activity
I6N98_RS15095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6N98_RS15105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6N98_RS15110	COG1522	sequence-specific DNA binding
I6N98_RS15120	COG0359	binds to the 23S rRNA
I6N98_RS15130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6N98_RS15135	COG0360	Binds together with S18 to 16S ribosomal RNA
I6N98_RS15145	COG0557	exoribonuclease II activity
I6N98_RS15155	COG3706	GGDEF domain
I6N98_RS15160	COG1024	Enoyl-CoA hydratase
I6N98_RS15205	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6N98_RS15215	COG0330	HflC and HflK could
I6N98_RS15220	COG0330	HflC and HflK could
I6N98_RS15225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6N98_RS15230	COG1923	regulation of RNA biosynthetic process
I6N98_RS15235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6N98_RS15240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6N98_RS15245	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6N98_RS15250	COG0802	atpase or kinase
I6N98_RS15265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6N98_RS15270	COG1162	GTPase activity
I6N98_RS15280	COG0688	phosphatidylethanolamine metabolic process
I6N98_RS15285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6N98_RS15290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6N98_RS15295	COG1509	lysine 2,3-aminomutase activity
I6N98_RS15310	COG3830	Belongs to the UPF0237 family
I6N98_RS15310	COG0560	Phosphoserine phosphatase
I6N98_RS15330	COG1047	Peptidyl-prolyl cis-trans
I6N98_RS15335	COG1073	alpha beta
I6N98_RS15350	COG1185	polyribonucleotide nucleotidyltransferase activity
I6N98_RS15355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6N98_RS15360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6N98_RS15365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6N98_RS15370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6N98_RS15375	COG0195	Participates in both transcription termination and antitermination
I6N98_RS15375	COG2251	uridine kinase activity
I6N98_RS15380	COG0779	Required for maturation of 30S ribosomal subunits
I6N98_RS15395	COG0149	triose-phosphate isomerase activity
I6N98_RS15400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6N98_RS15405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6N98_RS15410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6N98_RS15415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6N98_RS15425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6N98_RS15430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6N98_RS15435	COG0505	Belongs to the CarA family
I6N98_RS15445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6N98_RS15450	COG1295	ribonuclease BN
I6N98_RS15455	COG0484	heat shock protein binding
I6N98_RS15460	COG0443	Heat shock 70 kDa protein
I6N98_RS15465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6N98_RS15470	COG0497	DNA recombination
I6N98_RS15480	COG2914	Belongs to the UPF0125 (RnfH) family
I6N98_RS15485	COG2867	negative regulation of translational initiation
I6N98_RS15495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6N98_RS15510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6N98_RS15515	COG0248	Ppx GppA phosphatase
I6N98_RS15545	COG0330	HflC and HflK could
I6N98_RS15610	COG0415	Belongs to the DNA photolyase family
I6N98_RS15615	COG0415	Belongs to the DNA photolyase family
I6N98_RS15620	COG3046	protein related to deoxyribodipyrimidine photolyase
I6N98_RS15645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6N98_RS15650	COG1360	Flagellar Motor Protein
I6N98_RS15660	COG4771	TonB-dependent receptor
I6N98_RS15675	COG1090	epimerase
I6N98_RS15680	COG2124	cytochrome p450
I6N98_RS15705	COG0633	Ferredoxin
I6N98_RS15710	COG4221	oxidoreductase activity
I6N98_RS15735	COG1671	Belongs to the UPF0178 family
I6N98_RS15745	COG0784	Response regulator, receiver
I6N98_RS15745	COG2205	protein histidine kinase activity
I6N98_RS15745	COG5002	protein histidine kinase activity
I6N98_RS15755	COG4774	siderophore transport
I6N98_RS15760	COG0069	glutamate synthase activity
I6N98_RS15765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6N98_RS15770	COG0495	leucyl-tRNA aminoacylation
I6N98_RS15800	COG0840	transmembrane signaling receptor activity
I6N98_RS15820	COG1418	mRNA catabolic process
I6N98_RS15820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6N98_RS15825	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6N98_RS15840	COG0835	chemotaxis
I6N98_RS15850	COG0745	RESPONSE REGULATOR receiver
I6N98_RS15855	COG0784	Response regulator, receiver
I6N98_RS15855	COG2205	protein histidine kinase activity
I6N98_RS15860	COG0784	Response regulator, receiver
I6N98_RS15875	COG0582	viral genome integration into host DNA
I6N98_RS15925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6N98_RS15975	COG0457	Tetratricopeptide repeat
I6N98_RS15980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6N98_RS15985	COG1215	transferase activity, transferring glycosyl groups
I6N98_RS15990	COG1215	transferase activity, transferring glycosyl groups
I6N98_RS16010	COG2194	sulfuric ester hydrolase activity
I6N98_RS16015	COG2194	sulfuric ester hydrolase activity
I6N98_RS16025	COG2989	Protein conserved in bacteria
I6N98_RS16055	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS16060	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS16095	COG2010	Cytochrome c
I6N98_RS16100	COG1858	cytochrome C peroxidase
I6N98_RS16105	COG2010	Cytochrome c
I6N98_RS16125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6N98_RS16135	COG1454	alcohol dehydrogenase
I6N98_RS16170	COG1858	cytochrome C peroxidase
I6N98_RS16175	COG4771	TonB-dependent receptor
I6N98_RS16195	COG1858	cytochrome C peroxidase
I6N98_RS16200	COG4771	TonB-dependent receptor
I6N98_RS16215	COG0439	Biotin carboxylase
I6N98_RS16240	COG1252	NADH dehydrogenase
I6N98_RS16305	COG2205	protein histidine kinase activity
I6N98_RS16305	COG0784	Response regulator, receiver
I6N98_RS16320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6N98_RS16370	COG3901	Regulator of nitric oxide reductase transcription
I6N98_RS16370	COG0348	domain, Protein
I6N98_RS16375	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS16380	COG1125	glycine betaine transport
I6N98_RS16380	COG0517	IMP dehydrogenase activity
I6N98_RS16415	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS16420	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6N98_RS16420	COG1024	Enoyl-CoA hydratase
I6N98_RS16425	COG0183	Belongs to the thiolase family
I6N98_RS16475	COG4771	TonB-dependent receptor
I6N98_RS16515	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS16520	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS16535	COG1960	acyl-CoA dehydrogenase activity
I6N98_RS16555	COG0625	glutathione transferase activity
I6N98_RS16560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6N98_RS16565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6N98_RS16575	COG0183	Belongs to the thiolase family
I6N98_RS16580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6N98_RS16590	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
I6N98_RS16595	COG0145	ligase activity
I6N98_RS16605	COG0145	ligase activity
I6N98_RS16610	COG2130	NADP-dependent
I6N98_RS16660	COG4771	TonB-dependent receptor
I6N98_RS16675	COG0183	Belongs to the thiolase family
I6N98_RS16705	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS16715	COG4771	TonB-dependent receptor
I6N98_RS16720	COG4771	TonB-dependent receptor
I6N98_RS16725	COG0583	DNA-binding transcription factor activity
I6N98_RS16735	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6N98_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS16755	COG4774	siderophore transport
I6N98_RS16775	COG0657	acetylesterase activity
I6N98_RS16785	COG0651	ATP synthesis coupled electron transport
I6N98_RS16795	COG0651	ATP synthesis coupled electron transport
I6N98_RS16800	COG0651	ATP synthesis coupled electron transport
I6N98_RS16805	COG1006	Multisubunit Na H antiporter MnhC subunit
I6N98_RS16815	COG1320	monovalent cation:proton antiporter activity
I6N98_RS16835	COG0435	Glutathione S-transferase
I6N98_RS16875	COG4399	Belongs to the UPF0754 family
I6N98_RS16900	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6N98_RS16915	COG0277	FAD linked oxidase domain protein
I6N98_RS16920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6N98_RS16945	COG0450	alkyl hydroperoxide reductase
I6N98_RS16955	COG4372	Transposase
I6N98_RS16980	COG0126	phosphoglycerate kinase activity
I6N98_RS16985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6N98_RS17020	COG0022	dehydrogenase e1 component
I6N98_RS17025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6N98_RS17030	COG4638	Rieske (2fe-2S)
I6N98_RS17055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6N98_RS17060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6N98_RS17075	COG3038	cytochrome b561
I6N98_RS17080	COG2353	YceI-like domain
I6N98_RS17110	COG0848	biopolymer transport protein
I6N98_RS17115	COG0811	peptide transport
I6N98_RS17120	COG0811	peptide transport
I6N98_RS17135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6N98_RS17140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6N98_RS17145	COG0730	response to heat
I6N98_RS17170	COG0509	glycine decarboxylation via glycine cleavage system
I6N98_RS17175	COG1178	ABC-type Fe3 transport system permease component
I6N98_RS17185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6N98_RS17190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6N98_RS17195	COG0006	proline dipeptidase activity
I6N98_RS17200	COG3079	Belongs to the UPF0149 family
I6N98_RS17220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6N98_RS17225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6N98_RS17240	COG5002	protein histidine kinase activity
I6N98_RS17245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6N98_RS17250	COG0405	Gamma-glutamyltransferase
I6N98_RS17275	COG0347	Belongs to the P(II) protein family
I6N98_RS17280	COG0004	ammonium transporteR
I6N98_RS17285	COG0347	Belongs to the P(II) protein family
I6N98_RS17305	COG0411	ABC transporter
I6N98_RS17310	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6N98_RS17330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6N98_RS17335	COG0830	nickel cation binding
I6N98_RS17340	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6N98_RS17345	COG0804	urea catabolic process
I6N98_RS17350	COG0832	Belongs to the urease beta subunit family
I6N98_RS17355	COG0831	urea catabolic process
I6N98_RS17360	COG0829	nickel cation binding
I6N98_RS17370	COG0606	chelatase, subunit chli
I6N98_RS17400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N98_RS17430	COG0187	DNA topoisomerase II activity
I6N98_RS17435	COG3150	esterase
I6N98_RS17440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6N98_RS17450	COG1538	Outer membrane efflux protein
I6N98_RS17455	COG1519	Transferase
I6N98_RS17460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6N98_RS17475	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6N98_RS17480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6N98_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS17495	COG2816	NAD+ diphosphatase activity
I6N98_RS17515	COG0129	dihydroxy-acid dehydratase activity
I6N98_RS17520	COG0469	pyruvate kinase activity
I6N98_RS17540	COG0668	transmembrane transport
I6N98_RS17555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N98_RS17570	COG1959	2 iron, 2 sulfur cluster binding
I6N98_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS17580	COG1090	epimerase
I6N98_RS17600	COG0488	(ABC) transporter
I6N98_RS17615	COG2814	Major facilitator Superfamily
I6N98_RS17620	COG1846	Transcriptional regulator
I6N98_RS17650	COG1012	belongs to the aldehyde dehydrogenase family
I6N98_RS17655	COG0189	ligase activity
I6N98_RS17655	COG4067	protein conserved in archaea
I6N98_RS17660	COG0189	ligase activity
I6N98_RS17680	COG3634	alkyl hydroperoxide reductase activity
I6N98_RS17695	COG0217	transcriptional regulatory protein
I6N98_RS17730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6N98_RS17740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6N98_RS17760	COG1011	Hydrolase
I6N98_RS17765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6N98_RS17770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6N98_RS17775	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6N98_RS17790	COG1309	transcriptional regulator
I6N98_RS17795	COG2183	response to ionizing radiation
I6N98_RS17810	COG3134	Outer membrane lipoprotein
I6N98_RS17815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6N98_RS17845	COG0745	RESPONSE REGULATOR receiver
I6N98_RS17850	COG2205	protein histidine kinase activity
I6N98_RS17865	COG2959	enzyme of heme biosynthesis
I6N98_RS17885	COG0165	Argininosuccinate lyase
I6N98_RS17895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N98_RS17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N98_RS17920	COG0438	transferase activity, transferring glycosyl groups
I6N98_RS17940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6N98_RS17945	COG1392	Phosphate transport regulator
I6N98_RS17950	COG0306	phosphate transporter
I6N98_RS17965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6N98_RS17970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6N98_RS17975	COG2003	Belongs to the UPF0758 family
I6N98_RS17985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6N98_RS17990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6N98_RS17995	COG1309	transcriptional regulator
I6N98_RS18015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6N98_RS18020	COG1561	YicC-like family, N-terminal region
I6N98_RS18030	COG1758	RNA polymerase activity
I6N98_RS18035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6N98_RS18050	COG3321	synthase
I6N98_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS18050	COG0604	alcohol dehydrogenase
I6N98_RS18055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6N98_RS18080	COG2026	Addiction module toxin, RelE StbE family
I6N98_RS18085	COG2161	toxin-antitoxin pair type II binding
I6N98_RS18090	COG3153	acetyltransferase
I6N98_RS18140	COG1737	Transcriptional regulator
I6N98_RS18150	COG0210	DNA helicase
I6N98_RS18155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6N98_RS18165	COG1607	acyl-coa hydrolase
I6N98_RS18170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6N98_RS18185	COG3022	response to hydroperoxide
I6N98_RS18205	COG0826	peptidase U32
I6N98_RS18220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6N98_RS18230	COG1773	rubredoxin
I6N98_RS18240	COG1301	dicarboxylic acid transport
I6N98_RS18255	COG4221	oxidoreductase activity
I6N98_RS18265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N98_RS18270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N98_RS18275	COG0500	methyltransferase
I6N98_RS18285	COG0708	Exodeoxyribonuclease III
I6N98_RS18295	COG2204	response regulator
I6N98_RS18300	COG1271	oxidase subunit
I6N98_RS18305	COG1294	oxidase, subunit
I6N98_RS18310	COG1937	Protein conserved in bacteria
I6N98_RS18320	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6N98_RS18335	COG0471	metal ion transport
I6N98_RS18350	COG1704	LemA family
I6N98_RS18355	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6N98_RS18365	COG0189	ligase activity
I6N98_RS18370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6N98_RS18380	COG0183	Belongs to the thiolase family
I6N98_RS18385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6N98_RS18390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6N98_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
I6N98_RS18400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6N98_RS18405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6N98_RS18410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6N98_RS18415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6N98_RS18425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6N98_RS18435	COG0356	it plays a direct role in the translocation of protons across the membrane
I6N98_RS18445	COG1475	DNA binding
I6N98_RS18450	COG1192	Involved in chromosome partitioning
I6N98_RS18455	COG0357	Ribosomal RNA small subunit methyltransferase G
I6N98_RS18460	COG0445	tRNA wobble uridine modification
I6N98_RS18465	COG5002	protein histidine kinase activity
I6N98_RS18465	COG0784	Response regulator, receiver
I6N98_RS18475	COG4774	siderophore transport
I6N98_RS18480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6N98_RS18485	COG0706	membrane insertase activity
I6N98_RS18495	COG0594	ribonuclease P activity
I6N98_RS18500	COG0230	Belongs to the bacterial ribosomal protein bL34 family