locus-tag	class	description
GJE18_RS00060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GJE18_RS00065	COG2986	histidine ammonia-lyase
GJE18_RS00070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GJE18_RS00100	COG0592	DNA-directed DNA polymerase activity
GJE18_RS00105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GJE18_RS00115	COG0594	ribonuclease P activity
GJE18_RS00120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GJE18_RS00125	COG0445	tRNA wobble uridine modification
GJE18_RS00130	COG0357	Ribosomal RNA small subunit methyltransferase G
GJE18_RS00135	COG1475	DNA binding
GJE18_RS00140	COG0400	carboxylic ester hydrolase activity
GJE18_RS00145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GJE18_RS00150	COG0346	lactoylglutathione lyase activity
GJE18_RS00155	COG1846	Transcriptional regulator
GJE18_RS00175	COG2353	YceI-like domain
GJE18_RS00180	COG1966	Carbon starvation protein
GJE18_RS00185	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GJE18_RS00190	COG0830	nickel cation binding
GJE18_RS00195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GJE18_RS00200	COG0829	nickel cation binding
GJE18_RS00210	COG1279	arginine transmembrane transporter activity
GJE18_RS00235	COG0646	methionine synthase
GJE18_RS00235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GJE18_RS00240	COG0626	cystathionine gamma-synthase activity
GJE18_RS00245	COG0626	cystathionine gamma-synthase activity
GJE18_RS00250	COG1475	DNA binding
GJE18_RS00255	COG0668	transmembrane transport
GJE18_RS00260	COG4481	Protein conserved in bacteria
GJE18_RS00265	COG0012	GTP binding
GJE18_RS00275	COG2910	NAD(P)H-binding
GJE18_RS00280	COG0360	Binds together with S18 to 16S ribosomal RNA
GJE18_RS00290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GJE18_RS00315	COG1929	Belongs to the glycerate kinase type-1 family
GJE18_RS00325	COG0745	RESPONSE REGULATOR receiver
GJE18_RS00330	COG3850	Histidine kinase
GJE18_RS00330	COG5002	protein histidine kinase activity
GJE18_RS00340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GJE18_RS00355	COG3634	alkyl hydroperoxide reductase activity
GJE18_RS00360	COG0450	alkyl hydroperoxide reductase
GJE18_RS00370	COG0778	Nitroreductase
GJE18_RS00375	COG1823	symporter activity
GJE18_RS00380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GJE18_RS00400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GJE18_RS00405	COG2233	PERMEase
GJE18_RS00410	COG0517	IMP dehydrogenase activity
GJE18_RS00410	COG0516	GMP reductase activity
GJE18_RS00415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GJE18_RS00415	COG0519	Catalyzes the synthesis of GMP from XMP
GJE18_RS00425	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GJE18_RS00450	COG1609	Transcriptional regulator
GJE18_RS00470	COG5492	domain, Protein
GJE18_RS00490	COG2832	Protein of unknown function (DUF454)
GJE18_RS00500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GJE18_RS00520	COG1011	Hydrolase
GJE18_RS00545	COG0747	negative chemotaxis
GJE18_RS00550	COG0601	transmembrane transport
GJE18_RS00555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GJE18_RS00560	COG0444	Belongs to the ABC transporter superfamily
GJE18_RS00565	COG1124	(ABC) transporter
GJE18_RS00575	COG2076	Multidrug Resistance protein
GJE18_RS00580	COG2076	Multidrug Resistance protein
GJE18_RS00610	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GJE18_RS00615	COG1388	LysM domain
GJE18_RS00615	COG3942	CHAP domain
GJE18_RS00710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GJE18_RS00710	COG0574	Belongs to the PEP-utilizing enzyme family
GJE18_RS00715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GJE18_RS00720	COG0733	neurotransmitter:sodium symporter activity
GJE18_RS00725	COG2272	Belongs to the type-B carboxylesterase lipase family
GJE18_RS00735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GJE18_RS00740	COG0626	cystathionine gamma-synthase activity
GJE18_RS00760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GJE18_RS00775	COG0583	DNA-binding transcription factor activity
GJE18_RS00780	COG0067	glutamate synthase
GJE18_RS00780	COG0069	glutamate synthase activity
GJE18_RS00780	COG0070	glutamate synthase
GJE18_RS00785	COG0493	'glutamate synthase
GJE18_RS00795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GJE18_RS00795	COG1263	PTS System
GJE18_RS00800	COG0366	Alpha amylase catalytic
GJE18_RS00805	COG2188	Transcriptional regulator
GJE18_RS00820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GJE18_RS00825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GJE18_RS00830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GJE18_RS00855	COG1982	Orn Lys Arg decarboxylase major
GJE18_RS00860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GJE18_RS00865	COG3870	Protein conserved in bacteria
GJE18_RS00870	COG0470	DNA polymerase III
GJE18_RS00875	COG1774	PSP1 C-terminal conserved region
GJE18_RS00885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GJE18_RS00890	COG2827	Endonuclease containing a URI domain
GJE18_RS00895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GJE18_RS00900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GJE18_RS00900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GJE18_RS00905	COG0084	hydrolase, TatD family'
GJE18_RS00910	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GJE18_RS00915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GJE18_RS00920	COG4466	Protein conserved in bacteria
GJE18_RS00925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GJE18_RS00930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GJE18_RS00935	COG0251	oxidation-reduction process
GJE18_RS00940	COG2088	sporulation resulting in formation of a cellular spore
GJE18_RS00945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GJE18_RS00950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GJE18_RS00960	COG0193	aminoacyl-tRNA hydrolase activity
GJE18_RS00965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GJE18_RS00970	COG2244	polysaccharide biosynthetic process
GJE18_RS00975	COG3956	TIGRFAM MazG family protein
GJE18_RS00980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GJE18_RS00990	COG1098	S1 RNA binding domain
GJE18_RS01005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GJE18_RS01010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GJE18_RS01030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GJE18_RS01035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GJE18_RS01130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GJE18_RS01135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GJE18_RS01145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GJE18_RS01155	COG3880	PFAM UvrB UvrC protein
GJE18_RS01160	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GJE18_RS01170	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GJE18_RS01175	COG4956	integral membrane protein (PIN domain superfamily)
GJE18_RS01200	COG0215	cysteine-tRNA ligase activity
GJE18_RS01205	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GJE18_RS01215	COG3688	RNA-binding protein containing a PIN domain
GJE18_RS01225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GJE18_RS01230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GJE18_RS01235	COG0250	Participates in transcription elongation, termination and antitermination
GJE18_RS01240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GJE18_RS01245	COG0081	regulation of translation
GJE18_RS01250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GJE18_RS01260	COG2813	Specifically methylates the guanine in position
GJE18_RS01270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GJE18_RS01280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GJE18_RS01285	COG0049	tRNA binding
GJE18_RS01300	COG1473	amidohydrolase
GJE18_RS01310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GJE18_RS01320	COG1683	Conserved Protein
GJE18_RS01335	COG0693	protein deglycase activity
GJE18_RS01345	COG0346	lactoylglutathione lyase activity
GJE18_RS01355	COG1428	Deoxynucleoside kinase
GJE18_RS01360	COG1428	Deoxynucleoside kinase
GJE18_RS01370	COG0561	phosphatase activity
GJE18_RS01375	COG0431	NADPH-dependent FMN reductase
GJE18_RS01385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GJE18_RS01395	COG1737	Transcriptional regulator
GJE18_RS01400	COG1263	PTS System
GJE18_RS01400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GJE18_RS01400	COG2190	(PTS) system
GJE18_RS01415	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GJE18_RS01425	COG0318	PFAM AMP-dependent synthetase and ligase
GJE18_RS01430	COG0183	Belongs to the thiolase family
GJE18_RS01460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GJE18_RS01470	COG2363	Small membrane protein
GJE18_RS01475	COG0531	amino acid
GJE18_RS01490	COG1566	PFAM secretion protein HlyD family protein
GJE18_RS01495	COG2814	Major facilitator Superfamily
GJE18_RS01500	COG0095	Lipoate-protein ligase
GJE18_RS01515	COG0531	amino acid
GJE18_RS01530	COG0471	metal ion transport
GJE18_RS01535	COG4844	belongs to the
GJE18_RS01540	COG0655	NAD(P)H dehydrogenase (quinone) activity
GJE18_RS01550	COG1078	dGTPase activity
GJE18_RS01570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GJE18_RS01575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS01625	COG0582	viral genome integration into host DNA
GJE18_RS01630	COG2111	Na H antiporter
GJE18_RS01630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GJE18_RS01635	COG2111	Na H antiporter
GJE18_RS01640	COG1006	Multisubunit Na H antiporter MnhC subunit
GJE18_RS01650	COG1863	multisubunit Na H antiporter MnhE subunit
GJE18_RS01655	COG2212	antiporter activity
GJE18_RS01660	COG1320	monovalent cation:proton antiporter activity
GJE18_RS01670	COG0803	Belongs to the bacterial solute-binding protein 9 family
GJE18_RS01675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GJE18_RS01680	COG1121	(ABC) transporter
GJE18_RS01695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GJE18_RS01700	COG1134	teichoic acid transport
GJE18_RS01705	COG1682	transport, permease protein
GJE18_RS01710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GJE18_RS01715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GJE18_RS01725	COG1132	(ABC) transporter
GJE18_RS01745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GJE18_RS01750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GJE18_RS01755	COG1120	ATPase activity
GJE18_RS01760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS01765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS01775	COG3949	Membrane
GJE18_RS01790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GJE18_RS01795	COG1392	Phosphate transport regulator
GJE18_RS01800	COG0306	phosphate transporter
GJE18_RS01805	COG3942	CHAP domain
GJE18_RS01805	COG1388	LysM domain
GJE18_RS01825	COG2022	thiamine diphosphate biosynthetic process
GJE18_RS01835	COG0217	transcriptional regulatory protein
GJE18_RS01845	COG0583	DNA-binding transcription factor activity
GJE18_RS01850	COG2814	Major facilitator Superfamily
GJE18_RS01855	COG2839	Protein conserved in bacteria
GJE18_RS01885	COG1611	Belongs to the LOG family
GJE18_RS01890	COG1671	Belongs to the UPF0178 family
GJE18_RS01905	COG1266	CAAX protease self-immunity
GJE18_RS01910	COG1968	undecaprenyl-diphosphatase activity
GJE18_RS01915	COG4988	ABC transporter
GJE18_RS01920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GJE18_RS01930	COG0523	cobalamin synthesis protein
GJE18_RS01935	COG4989	oxidoreductase activity
GJE18_RS01945	COG0039	L-malate dehydrogenase activity
GJE18_RS01965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GJE18_RS01970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GJE18_RS01975	COG1349	DNA-binding transcription factor activity
GJE18_RS01980	COG1105	Belongs to the carbohydrate kinase PfkB family
GJE18_RS01985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GJE18_RS01985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GJE18_RS01985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GJE18_RS01990	COG1253	flavin adenine dinucleotide binding
GJE18_RS01995	COG0463	Glycosyl transferase, family 2
GJE18_RS02015	COG0720	synthase
GJE18_RS02025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GJE18_RS02025	COG0512	Glutamine amidotransferase of anthranilate synthase
GJE18_RS02030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GJE18_RS02030	COG0512	Glutamine amidotransferase of anthranilate synthase
GJE18_RS02055	COG1368	sulfuric ester hydrolase activity
GJE18_RS02065	COG0488	(ABC) transporter
GJE18_RS02070	COG0514	ATP-dependent DNA helicase (RecQ)
GJE18_RS02075	COG0517	IMP dehydrogenase activity
GJE18_RS02075	COG1125	glycine betaine transport
GJE18_RS02080	COG1174	glycine betaine transport
GJE18_RS02085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GJE18_RS02100	COG3104	oligopeptide transport
GJE18_RS02105	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GJE18_RS02115	COG1780	Probably involved in ribonucleotide reductase function
GJE18_RS02120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GJE18_RS02125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GJE18_RS02155	COG1929	Belongs to the glycerate kinase type-1 family
GJE18_RS02160	COG2195	Cleaves the N-terminal amino acid of tripeptides
GJE18_RS02190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GJE18_RS02195	COG1739	Uncharacterized protein family UPF0029
GJE18_RS02205	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GJE18_RS02215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GJE18_RS02220	COG0653	protein targeting
GJE18_RS02260	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GJE18_RS02265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GJE18_RS02270	COG0110	maltose O-acetyltransferase activity
GJE18_RS02280	COG0492	ferredoxin-NADP+ reductase activity
GJE18_RS02285	COG1660	Displays ATPase and GTPase activities
GJE18_RS02290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GJE18_RS02295	COG1481	regulation of sporulation
GJE18_RS02320	COG1278	Cold shock
GJE18_RS02330	COG2514	catechol 2,3-dioxygenase activity
GJE18_RS02345	COG1090	epimerase
GJE18_RS02370	COG0126	phosphoglycerate kinase activity
GJE18_RS02375	COG0149	triose-phosphate isomerase activity
GJE18_RS02380	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GJE18_RS02385	COG0148	phosphopyruvate hydratase activity
GJE18_RS02395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GJE18_RS02400	COG1647	Serine aminopeptidase, S33
GJE18_RS02405	COG0557	exoribonuclease II activity
GJE18_RS02425	COG0582	viral genome integration into host DNA
GJE18_RS02520	COG0477	Major facilitator Superfamily
GJE18_RS02535	COG0710	3-dehydroquinate dehydratase activity
GJE18_RS02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GJE18_RS02550	COG1393	Belongs to the ArsC family
GJE18_RS02560	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GJE18_RS02570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GJE18_RS02575	COG2011	ABC-type metal ion transport system permease component
GJE18_RS02580	COG1464	Belongs to the NlpA lipoprotein family
GJE18_RS02590	COG0396	ATPase activity
GJE18_RS02595	COG0719	Fe-S assembly protein
GJE18_RS02605	COG0822	iron-sulfur transferase activity
GJE18_RS02610	COG0719	Fe-S assembly protein
GJE18_RS02615	COG1253	flavin adenine dinucleotide binding
GJE18_RS02620	COG2070	2-Nitropropane dioxygenase
GJE18_RS02630	COG1801	Protein of unknown function DUF72
GJE18_RS02635	COG0730	response to heat
GJE18_RS02640	COG0737	Belongs to the 5'-nucleotidase family
GJE18_RS02650	COG4470	Protein conserved in bacteria
GJE18_RS02660	COG2445	Protein of unknown function DUF86
GJE18_RS02665	COG0647	UMP catabolic process
GJE18_RS02670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GJE18_RS02685	COG1696	Membrane protein involved in D-alanine export
GJE18_RS02695	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GJE18_RS02700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GJE18_RS02705	COG4837	Protein of unknown function (DUF1462)
GJE18_RS02710	COG1252	NADH dehydrogenase
GJE18_RS02720	COG0316	Belongs to the HesB IscA family
GJE18_RS02725	COG1252	NADH dehydrogenase
GJE18_RS02730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GJE18_RS02735	COG2056	Na+-H+ antiporter family
GJE18_RS02740	COG2050	protein possibly involved in aromatic compounds catabolism
GJE18_RS02750	COG1320	monovalent cation:proton antiporter activity
GJE18_RS02755	COG2212	antiporter activity
GJE18_RS02765	COG0651	ATP synthesis coupled electron transport
GJE18_RS02770	COG1006	Multisubunit Na H antiporter MnhC subunit
GJE18_RS02775	COG2111	Na H antiporter
GJE18_RS02780	COG2111	Na H antiporter
GJE18_RS02780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GJE18_RS02790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GJE18_RS02810	COG1098	S1 RNA binding domain
GJE18_RS02815	COG1012	belongs to the aldehyde dehydrogenase family
GJE18_RS02830	COG0584	glycerophosphoryl diester phosphodiesterase
GJE18_RS02835	COG0165	Argininosuccinate lyase
GJE18_RS02840	COG0137	argininosuccinate synthase activity
GJE18_RS02850	COG0681	Belongs to the peptidase S26 family
GJE18_RS02860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GJE18_RS02870	COG0179	Fumarylacetoacetate (FAA) hydrolase
GJE18_RS02880	COG0446	pyridine nucleotide-disulphide oxidoreductase
GJE18_RS02885	COG0561	phosphatase activity
GJE18_RS02890	COG2151	metal-sulfur cluster biosynthetic enzyme
GJE18_RS02895	COG0542	response to heat
GJE18_RS02920	COG0601	transmembrane transport
GJE18_RS02925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GJE18_RS02930	COG0444	Belongs to the ABC transporter superfamily
GJE18_RS02935	COG4608	Belongs to the ABC transporter superfamily
GJE18_RS02940	COG4166	transmembrane transport
GJE18_RS02945	COG0180	Tryptophanyl-tRNA synthetase
GJE18_RS02950	COG1393	Belongs to the ArsC family
GJE18_RS02955	COG4862	establishment of competence for transformation
GJE18_RS02965	COG1164	Oligoendopeptidase f
GJE18_RS02975	COG2346	COG2346, Truncated hemoglobins
GJE18_RS02980	COG4116	CYTH
GJE18_RS02990	COG2357	RelA SpoT domain protein
GJE18_RS02995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GJE18_RS03000	COG0564	pseudouridine synthase activity
GJE18_RS03005	COG2239	Acts as a magnesium transporter
GJE18_RS03010	COG0475	glutathione-regulated potassium exporter activity
GJE18_RS03010	COG0569	domain protein
GJE18_RS03020	COG0628	permease
GJE18_RS03025	COG1115	amino acid carrier protein
GJE18_RS03030	COG2382	esterase
GJE18_RS03035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GJE18_RS03045	COG2814	Major facilitator Superfamily
GJE18_RS03050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GJE18_RS03055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GJE18_RS03065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GJE18_RS03070	COG0861	Integral membrane protein TerC family
GJE18_RS03075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GJE18_RS03080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GJE18_RS03085	COG0737	Belongs to the 5'-nucleotidase family
GJE18_RS03100	COG4873	Protein conserved in bacteria
GJE18_RS03145	COG4619	ABC transporter
GJE18_RS03150	COG0390	transport system, permease component
GJE18_RS03155	COG1575	Belongs to the MenA family. Type 1 subfamily
GJE18_RS03160	COG1169	isochorismate synthase
GJE18_RS03165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GJE18_RS03170	COG0596	Alpha beta hydrolase
GJE18_RS03175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GJE18_RS03180	COG0436	Aminotransferase
GJE18_RS03185	COG3594	Acyltransferase
GJE18_RS03205	COG1316	TRANSCRIPTIONal
GJE18_RS03210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GJE18_RS03215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GJE18_RS03235	COG0463	Glycosyl transferase, family 2
GJE18_RS03235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GJE18_RS03240	COG0438	transferase activity, transferring glycosyl groups
GJE18_RS03260	COG1134	teichoic acid transport
GJE18_RS03275	COG1845	cytochrome c oxidase, subunit III
GJE18_RS03285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GJE18_RS03295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GJE18_RS03295	COG1017	nitric oxide dioxygenase activity
GJE18_RS03300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GJE18_RS03305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GJE18_RS03315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GJE18_RS03320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GJE18_RS03330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GJE18_RS03335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GJE18_RS03340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GJE18_RS03350	COG0138	bifunctional purine biosynthesis protein purh
GJE18_RS03355	COG0151	Belongs to the GarS family
GJE18_RS03365	COG1122	ATPase activity
GJE18_RS03370	COG4721	ABC-type cobalt transport system, permease component
GJE18_RS03380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GJE18_RS03395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GJE18_RS03400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GJE18_RS03405	COG1271	oxidase subunit
GJE18_RS03410	COG1294	oxidase, subunit
GJE18_RS03415	COG0569	domain protein
GJE18_RS03425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GJE18_RS03440	COG0242	peptide deformylase activity
GJE18_RS03470	COG4476	Belongs to the UPF0223 family
GJE18_RS03490	COG1177	transmembrane transport
GJE18_RS03495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GJE18_RS03510	COG4493	Belongs to the UPF0637 family
GJE18_RS03515	COG0483	inositol monophosphate 1-phosphatase activity
GJE18_RS03530	COG1902	pentaerythritol trinitrate reductase activity
GJE18_RS03535	COG4896	Protein conserved in bacteria
GJE18_RS03540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GJE18_RS03545	COG4838	Belongs to the UPF0358 family
GJE18_RS03550	COG0772	Belongs to the SEDS family
GJE18_RS03565	COG0109	protoheme IX farnesyltransferase activity
GJE18_RS03580	COG3679	Belongs to the UPF0342 family
GJE18_RS03590	COG4471	UPF0298 protein
GJE18_RS03600	COG0742	ribosomal rna small subunit methyltransferase
GJE18_RS03605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GJE18_RS03610	COG1323	Belongs to the UPF0348 family
GJE18_RS03620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GJE18_RS03625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GJE18_RS03630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GJE18_RS03635	COG0072	phenylalanine-tRNA ligase activity
GJE18_RS03640	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GJE18_RS03645	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GJE18_RS03655	COG1796	DNA polymerase
GJE18_RS03655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GJE18_RS03660	COG1193	negative regulation of DNA recombination
GJE18_RS03665	COG3118	belongs to the thioredoxin family
GJE18_RS03670	COG0322	excinuclease ABC activity
GJE18_RS03675	COG2009	succinate dehydrogenase
GJE18_RS03680	COG1053	succinate dehydrogenase
GJE18_RS03685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GJE18_RS03710	COG0739	heme binding
GJE18_RS03735	COG0582	viral genome integration into host DNA
GJE18_RS03850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GJE18_RS03930	COG4695	Portal protein
GJE18_RS03985	COG0739	heme binding
GJE18_RS04025	COG1388	LysM domain
GJE18_RS04025	COG0860	N-Acetylmuramoyl-L-alanine amidase
GJE18_RS04060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GJE18_RS04075	COG0454	-acetyltransferase
GJE18_RS04080	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GJE18_RS04085	COG2001	Belongs to the MraZ family
GJE18_RS04090	COG0275	rRNA processing
GJE18_RS04095	COG4839	cell division protein FtsL
GJE18_RS04120	COG0849	cell division
GJE18_RS04125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GJE18_RS04135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GJE18_RS04140	COG1799	cell septum assembly
GJE18_RS04145	COG0762	integral membrane protein
GJE18_RS04155	COG3599	regulation of cell shape
GJE18_RS04170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GJE18_RS04175	COG0564	pseudouridine synthase activity
GJE18_RS04180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GJE18_RS04190	COG0540	Belongs to the ATCase OTCase family
GJE18_RS04200	COG0505	Belongs to the CarA family
GJE18_RS04205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GJE18_RS04215	COG0167	dihydroorotate dehydrogenase activity
GJE18_RS04220	COG0284	orotidine-5'-phosphate decarboxylase activity
GJE18_RS04225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GJE18_RS04235	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GJE18_RS04245	COG1758	RNA polymerase activity
GJE18_RS04250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GJE18_RS04255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GJE18_RS04265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GJE18_RS04270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GJE18_RS04270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GJE18_RS04275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GJE18_RS04290	COG2124	cytochrome p450
GJE18_RS04295	COG1162	GTPase activity
GJE18_RS04300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GJE18_RS04305	COG1564	THIamine pyrophosphokinase
GJE18_RS04315	COG1302	Protein conserved in bacteria
GJE18_RS04325	COG1760	l-serine dehydratase
GJE18_RS04330	COG1760	l-serine dehydratase
GJE18_RS04335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GJE18_RS04340	COG1349	DNA-binding transcription factor activity
GJE18_RS04345	COG0416	fatty acid biosynthetic process
GJE18_RS04355	COG1028	Short-chain dehydrogenase reductase Sdr
GJE18_RS04360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GJE18_RS04365	COG0571	ribonuclease III activity
GJE18_RS04370	COG1196	nuclear chromosome segregation
GJE18_RS04375	COG0552	protein localization to endoplasmic reticulum
GJE18_RS04380	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GJE18_RS04385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GJE18_RS04390	COG0228	four-way junction DNA binding
GJE18_RS04400	COG0336	Belongs to the RNA methyltransferase TrmD family
GJE18_RS04405	COG0335	large ribosomal subunit rRNA binding
GJE18_RS04430	COG4485	Bacterial membrane protein, YfhO
GJE18_RS04435	COG4485	Bacterial membrane protein, YfhO
GJE18_RS04450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GJE18_RS04460	COG0045	succinate-CoA ligase (ADP-forming) activity
GJE18_RS04470	COG0758	DNA mediated transformation
GJE18_RS04475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GJE18_RS04485	COG4974	Belongs to the 'phage' integrase family
GJE18_RS04495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GJE18_RS04500	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GJE18_RS04505	COG0052	Belongs to the universal ribosomal protein uS2 family
GJE18_RS04510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GJE18_RS04515	COG0528	UMP kinase activity
GJE18_RS04520	COG0233	cytoplasmic translational termination
GJE18_RS04525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GJE18_RS04530	COG4589	Belongs to the CDS family
GJE18_RS04535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GJE18_RS04545	COG0442	prolyl-tRNA aminoacylation
GJE18_RS04555	COG0779	Required for maturation of 30S ribosomal subunits
GJE18_RS04560	COG0195	Participates in both transcription termination and antitermination
GJE18_RS04565	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GJE18_RS04570	COG1358	cellular component organization or biogenesis
GJE18_RS04575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GJE18_RS04585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GJE18_RS04590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GJE18_RS04595	COG0196	riboflavin kinase activity
GJE18_RS04605	COG1185	polyribonucleotide nucleotidyltransferase activity
GJE18_RS04615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GJE18_RS04625	COG2188	Transcriptional regulator
GJE18_RS04630	COG0612	Peptidase, M16
GJE18_RS04635	COG0612	Peptidase, M16
GJE18_RS04640	COG0300	oxidoreductase activity
GJE18_RS04660	COG1058	Belongs to the CinA family
GJE18_RS04660	COG1546	Belongs to the CinA family
GJE18_RS04665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GJE18_RS04670	COG1418	mRNA catabolic process
GJE18_RS04690	COG1692	metallophosphoesterase
GJE18_RS04695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GJE18_RS04695	COG0674	pyruvate-flavodoxin oxidoreductase activity
GJE18_RS04700	COG1013	pyruvate-flavodoxin oxidoreductase activity
GJE18_RS04710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GJE18_RS04730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GJE18_RS04740	COG1619	proteins homologs of microcin C7 resistance protein MccF
GJE18_RS04745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GJE18_RS04755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GJE18_RS04765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GJE18_RS04770	COG1923	regulation of RNA biosynthetic process
GJE18_RS04775	COG0386	Belongs to the glutathione peroxidase family
GJE18_RS04785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GJE18_RS04790	COG0789	Transcriptional regulator
GJE18_RS04810	COG1131	(ABC) transporter
GJE18_RS04815	COG0842	Transport permease protein
GJE18_RS04820	COG4585	Histidine kinase
GJE18_RS04825	COG2197	response regulator
GJE18_RS04855	COG0527	aspartate kinase activity
GJE18_RS04860	COG0460	homoserine dehydrogenase
GJE18_RS04865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GJE18_RS04870	COG0083	homoserine kinase activity
GJE18_RS04875	COG0561	phosphatase activity
GJE18_RS04885	COG0833	amino acid
GJE18_RS04890	COG0753	catalase activity
GJE18_RS04900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GJE18_RS04905	COG0516	GMP reductase activity
GJE18_RS04910	COG2340	Cysteine-rich secretory protein family
GJE18_RS04940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GJE18_RS04950	COG4224	UPF0291 protein
GJE18_RS04960	COG3763	UPF0154 protein
GJE18_RS04965	COG4846	Membrane protein involved in cytochrome C biogenesis
GJE18_RS04970	COG0420	3'-5' exonuclease activity
GJE18_RS04975	COG0419	ATPase involved in DNA repair
GJE18_RS04980	COG1970	mechanosensitive ion channel activity
GJE18_RS04985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GJE18_RS04995	COG0824	Thioesterase
GJE18_RS05005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GJE18_RS05010	COG0187	DNA topoisomerase II activity
GJE18_RS05015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GJE18_RS05020	COG1115	amino acid carrier protein
GJE18_RS05025	COG3711	transcriptional antiterminator
GJE18_RS05035	COG0628	permease
GJE18_RS05065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GJE18_RS05070	COG0287	Prephenate dehydrogenase
GJE18_RS05075	COG1363	Peptidase, m42
GJE18_RS05080	COG2348	transferase activity, transferring amino-acyl groups
GJE18_RS05085	COG2348	transferase activity, transferring amino-acyl groups
GJE18_RS05100	COG1105	Belongs to the carbohydrate kinase PfkB family
GJE18_RS05105	COG2996	Protein conserved in bacteria
GJE18_RS05110	COG0488	(ABC) transporter
GJE18_RS05115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GJE18_RS05120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GJE18_RS05125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GJE18_RS05130	COG2171	N-acyltransferase activity
GJE18_RS05135	COG1473	amidohydrolase
GJE18_RS05150	COG1278	Cold shock
GJE18_RS05170	COG3853	Toxic anion resistance protein (TelA)
GJE18_RS05175	COG1114	Component of the transport system for branched-chain amino acids
GJE18_RS05180	COG4548	von Willebrand factor, type A
GJE18_RS05185	COG0714	Associated with various cellular activities
GJE18_RS05210	COG5002	protein histidine kinase activity
GJE18_RS05215	COG0745	RESPONSE REGULATOR receiver
GJE18_RS05220	COG0671	phosphoesterase, PA-phosphatase related
GJE18_RS05240	COG4479	Belongs to the UPF0346 family
GJE18_RS05250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GJE18_RS05270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GJE18_RS05280	COG1413	lyase activity
GJE18_RS05290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GJE18_RS05295	COG0328	RNA-DNA hybrid ribonuclease activity
GJE18_RS05300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GJE18_RS05305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GJE18_RS05310	COG2962	Rard protein
GJE18_RS05315	COG0116	Belongs to the methyltransferase superfamily
GJE18_RS05330	COG4474	Belongs to the UPF0398 family
GJE18_RS05340	COG3331	DNA recombination
GJE18_RS05345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GJE18_RS05345	COG4499	WXG100 protein secretion system (Wss), protein YukC
GJE18_RS05355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GJE18_RS05360	COG3935	DnaD domain protein
GJE18_RS05365	COG0017	Asparaginyl-tRNA synthetase
GJE18_RS05370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GJE18_RS05370	COG1199	ATP-dependent helicase activity
GJE18_RS05380	COG0617	tRNA 3'-terminal CCA addition
GJE18_RS05385	COG0438	transferase activity, transferring glycosyl groups
GJE18_RS05390	COG1694	Mazg nucleotide pyrophosphohydrolase
GJE18_RS05395	COG2738	Putative neutral zinc metallopeptidase
GJE18_RS05400	COG4347	Protein of unknown function (DUF1405)
GJE18_RS05405	COG5582	Belongs to the UPF0302 family
GJE18_RS05410	COG0457	Tetratricopeptide repeat
GJE18_RS05420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GJE18_RS05425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GJE18_RS05430	COG0105	UTP biosynthetic process
GJE18_RS05435	COG0142	geranyltranstransferase activity
GJE18_RS05440	COG2226	methyltransferase
GJE18_RS05455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GJE18_RS05465	COG0539	negative regulation of cytoplasmic translation
GJE18_RS05470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GJE18_RS05475	COG0252	asparaginase activity
GJE18_RS05480	COG0492	ferredoxin-NADP+ reductase activity
GJE18_RS05490	COG0514	ATP-dependent DNA helicase (RecQ)
GJE18_RS05500	COG1141	Ferredoxin
GJE18_RS05510	COG5002	protein histidine kinase activity
GJE18_RS05515	COG0745	RESPONSE REGULATOR receiver
GJE18_RS05520	COG1187	pseudouridine synthase activity
GJE18_RS05525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GJE18_RS05530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GJE18_RS05540	COG4974	Belongs to the 'phage' integrase family
GJE18_RS05545	COG0735	belongs to the Fur family
GJE18_RS05550	COG0494	nUDIX hydrolase
GJE18_RS05555	COG0667	Aldo Keto reductase
GJE18_RS05565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GJE18_RS05570	COG1234	tRNA 3'-trailer cleavage
GJE18_RS05575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GJE18_RS05590	COG2195	Cleaves the N-terminal amino acid of tripeptides
GJE18_RS05600	COG4129	membrane
GJE18_RS05610	COG0508	dehydrogenase complex catalyzes the overall conversion of
GJE18_RS05615	COG0022	dehydrogenase e1 component
GJE18_RS05620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GJE18_RS05625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GJE18_RS05630	COG3426	butyrate kinase activity
GJE18_RS05635	COG0280	phosphate acetyltransferase
GJE18_RS05640	COG0497	DNA recombination
GJE18_RS05650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GJE18_RS05660	COG1722	exodeoxyribonuclease VII activity
GJE18_RS05665	COG1570	exodeoxyribonuclease VII activity
GJE18_RS05675	COG1302	Protein conserved in bacteria
GJE18_RS05680	COG0439	Biotin carboxylase
GJE18_RS05685	COG0511	ligase activity, forming carbon-carbon bonds
GJE18_RS05690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GJE18_RS05695	COG0006	proline dipeptidase activity
GJE18_RS05710	COG0095	Lipoate-protein ligase
GJE18_RS05715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GJE18_RS05720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GJE18_RS05725	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GJE18_RS05735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GJE18_RS05760	COG1459	type II secretion system
GJE18_RS05765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GJE18_RS05770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GJE18_RS05775	COG0011	TIGRFAM Protein of
GJE18_RS05780	COG1940	carbohydrate kinase activity
GJE18_RS05785	COG4483	Protein conserved in bacteria
GJE18_RS05790	COG0705	Rhomboid family
GJE18_RS05795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GJE18_RS05800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GJE18_RS05805	COG0704	Plays a role in the regulation of phosphate uptake
GJE18_RS05810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GJE18_RS05815	COG0581	inorganic phosphate transmembrane transporter activity
GJE18_RS05820	COG0573	inorganic phosphate transmembrane transporter activity
GJE18_RS05825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GJE18_RS05840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GJE18_RS05850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GJE18_RS05855	COG1121	(ABC) transporter
GJE18_RS05860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GJE18_RS05865	COG0513	Belongs to the DEAD box helicase family
GJE18_RS05870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GJE18_RS05875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GJE18_RS05880	COG2384	SAM-dependent methyltransferase
GJE18_RS05885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GJE18_RS05890	COG0358	DNA primase activity
GJE18_RS05895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GJE18_RS05900	COG0517	IMP dehydrogenase activity
GJE18_RS05905	COG0423	glycine-tRNA ligase activity
GJE18_RS05910	COG1381	Involved in DNA repair and RecF pathway recombination
GJE18_RS05920	COG0295	cytidine deaminase activity
GJE18_RS05930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GJE18_RS05935	COG1702	phosphate starvation-inducible protein PhoH
GJE18_RS05945	COG4864	UPF0365 protein
GJE18_RS05950	COG1030	water channel activity
GJE18_RS05960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GJE18_RS05965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GJE18_RS05975	COG0484	heat shock protein binding
GJE18_RS05985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GJE18_RS05990	COG1420	regulation of RNA biosynthetic process
GJE18_RS05995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GJE18_RS06005	COG0268	Binds directly to 16S ribosomal RNA
GJE18_RS06010	COG1466	dna polymerase III delta subunit
GJE18_RS06020	COG2131	deaminase
GJE18_RS06025	COG1555	photosystem II stabilization
GJE18_RS06025	COG1596	polysaccharide export
GJE18_RS06030	COG2226	methyltransferase
GJE18_RS06035	COG0799	negative regulation of ribosome biogenesis
GJE18_RS06040	COG1713	HD superfamily hydrolase involved in NAD metabolism
GJE18_RS06050	COG1534	Rna-binding protein
GJE18_RS06060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GJE18_RS06065	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GJE18_RS06070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GJE18_RS06075	COG1914	H( )-stimulated, divalent metal cation uptake system
GJE18_RS06080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GJE18_RS06085	COG0439	Biotin carboxylase
GJE18_RS06090	COG0511	ligase activity, forming carbon-carbon bonds
GJE18_RS06095	COG1984	allophanate hydrolase subunit 2
GJE18_RS06100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GJE18_RS06105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GJE18_RS06110	COG0572	uridine kinase
GJE18_RS06125	COG4122	O-methyltransferase activity
GJE18_RS06130	COG3906	Belongs to the UPF0473 family
GJE18_RS06135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GJE18_RS06140	COG4472	Bacterial protein of unknown function (DUF965)
GJE18_RS06150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GJE18_RS06160	COG0482	sulfurtransferase activity
GJE18_RS06165	COG1104	cysteine desulfurase activity
GJE18_RS06170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GJE18_RS06190	COG1959	2 iron, 2 sulfur cluster binding
GJE18_RS06195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GJE18_RS06200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GJE18_RS06210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GJE18_RS06220	COG0860	N-Acetylmuramoyl-L-alanine amidase
GJE18_RS06225	COG1490	D-aminoacyl-tRNA deacylase activity
GJE18_RS06235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GJE18_RS06240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GJE18_RS06240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GJE18_RS06245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GJE18_RS06245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GJE18_RS06250	COG1862	Preprotein translocase
GJE18_RS06265	COG2255	four-way junction helicase activity
GJE18_RS06270	COG0632	four-way junction helicase activity
GJE18_RS06275	COG4492	Belongs to the UPF0735 family
GJE18_RS06290	COG2868	ribosomal protein
GJE18_RS06295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GJE18_RS06305	COG1792	Involved in formation and maintenance of cell shape
GJE18_RS06320	COG2003	Belongs to the UPF0758 family
GJE18_RS06325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GJE18_RS06330	COG0285	dihydrofolate synthase activity
GJE18_RS06335	COG0525	valine-tRNA ligase activity
GJE18_RS06340	COG2818	Glycosylase
GJE18_RS06345	COG3180	Ammonia monooxygenase
GJE18_RS06365	COG0181	hydroxymethylbilane synthase activity
GJE18_RS06370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GJE18_RS06375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GJE18_RS06380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GJE18_RS06390	COG0544	peptidyl-prolyl cis-trans isomerase activity
GJE18_RS06405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GJE18_RS06410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GJE18_RS06415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GJE18_RS06420	COG0833	amino acid
GJE18_RS06425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GJE18_RS06430	COG1484	DNA-dependent DNA replication
GJE18_RS06435	COG3611	Membrane attachment protein
GJE18_RS06440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GJE18_RS06445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GJE18_RS06450	COG0237	dephospho-CoA kinase activity
GJE18_RS06455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GJE18_RS06460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GJE18_RS06460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GJE18_RS06465	COG5002	protein histidine kinase activity
GJE18_RS06470	COG0745	RESPONSE REGULATOR receiver
GJE18_RS06475	COG0538	isocitrate dehydrogenase activity
GJE18_RS06480	COG0372	Belongs to the citrate synthase family
GJE18_RS06485	COG0469	pyruvate kinase activity
GJE18_RS06490	COG0205	6-phosphofructokinase activity
GJE18_RS06495	COG0825	malonyl-CoA metabolic process
GJE18_RS06500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GJE18_RS06505	COG0281	malic enzyme
GJE18_RS06510	COG0587	DNA-directed DNA polymerase activity
GJE18_RS06515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GJE18_RS06520	COG4109	DRTGG domain
GJE18_RS06530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GJE18_RS06535	COG0006	proline dipeptidase activity
GJE18_RS06545	COG0589	response to stress
GJE18_RS06550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GJE18_RS06555	COG0827	DNA restriction-modification system
GJE18_RS06560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GJE18_RS06565	COG1714	RDD family
GJE18_RS06570	COG0616	signal peptide processing
GJE18_RS06575	COG0730	response to heat
GJE18_RS06580	COG0301	tRNA thio-modification
GJE18_RS06585	COG1104	cysteine desulfurase activity
GJE18_RS06590	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GJE18_RS06595	COG1956	GAF domain-containing protein
GJE18_RS06600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GJE18_RS06610	COG0584	glycerophosphoryl diester phosphodiesterase
GJE18_RS06615	COG1764	response to oxidative stress
GJE18_RS06620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GJE18_RS06625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GJE18_RS06635	COG0204	Acyl-transferase
GJE18_RS06640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GJE18_RS06645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GJE18_RS06650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GJE18_RS06655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GJE18_RS06660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GJE18_RS06665	COG0454	-acetyltransferase
GJE18_RS06670	COG0123	including yeast histone deacetylase and acetoin utilization protein
GJE18_RS06675	COG1609	Transcriptional regulator
GJE18_RS06680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GJE18_RS06680	COG1605	Chorismate mutase
GJE18_RS06690	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GJE18_RS06695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GJE18_RS06700	COG1674	ftsk spoiiie
GJE18_RS06705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GJE18_RS06710	COG4848	Belongs to the UPF0354 family
GJE18_RS06715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GJE18_RS06720	COG1363	Peptidase, m42
GJE18_RS06730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GJE18_RS06735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GJE18_RS06740	COG0510	thiamine kinase activity
GJE18_RS06745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GJE18_RS06750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GJE18_RS06760	COG1187	pseudouridine synthase activity
GJE18_RS06765	COG2244	polysaccharide biosynthetic process
GJE18_RS06770	COG2081	HI0933 family
GJE18_RS06775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GJE18_RS06780	COG0495	leucyl-tRNA aminoacylation
GJE18_RS06785	COG2814	Major facilitator Superfamily
GJE18_RS06790	COG1242	4 iron, 4 sulfur cluster binding
GJE18_RS06795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GJE18_RS06805	COG0039	L-malate dehydrogenase activity
GJE18_RS06810	COG2267	carboxylic ester hydrolase activity
GJE18_RS06820	COG0506	proline dehydrogenase activity
GJE18_RS06825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GJE18_RS06840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GJE18_RS06840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GJE18_RS06850	COG4193	domain, Protein
GJE18_RS06850	COG5632	N-Acetylmuramoyl-L-alanine amidase
GJE18_RS06850	COG3266	domain, Protein
GJE18_RS06860	COG1595	DNA-templated transcription, initiation
GJE18_RS06875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GJE18_RS06885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GJE18_RS06890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GJE18_RS06895	COG0656	L-ascorbic acid biosynthetic process
GJE18_RS06905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GJE18_RS06910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GJE18_RS06915	COG1506	peptidase
GJE18_RS06925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GJE18_RS06945	COG1302	Protein conserved in bacteria
GJE18_RS06970	COG0860	N-Acetylmuramoyl-L-alanine amidase
GJE18_RS06970	COG1388	LysM domain
GJE18_RS07015	COG5434	Belongs to the glycosyl hydrolase 28 family
GJE18_RS07100	COG1783	phage Terminase large subunit
GJE18_RS07200	COG0305	Participates in initiation and elongation during chromosome replication
GJE18_RS07285	COG0582	viral genome integration into host DNA
GJE18_RS07350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GJE18_RS07355	COG2329	Antibiotic biosynthesis monooxygenase
GJE18_RS07365	COG1131	(ABC) transporter
GJE18_RS07370	COG0537	adenosine 5'-monophosphoramidase activity
GJE18_RS07380	COG1846	Transcriptional regulator
GJE18_RS07390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GJE18_RS07395	COG3481	metal-dependent phosphohydrolase, HD sub domain
GJE18_RS07400	COG4717	serine-type aminopeptidase activity
GJE18_RS07405	COG0420	3'-5' exonuclease activity
GJE18_RS07410	COG3679	Belongs to the UPF0342 family
GJE18_RS07415	COG4399	Belongs to the UPF0754 family
GJE18_RS07455	COG4932	domain protein
GJE18_RS07460	COG1301	dicarboxylic acid transport
GJE18_RS07475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GJE18_RS07485	COG2197	response regulator
GJE18_RS07490	COG4585	Histidine kinase
GJE18_RS07490	COG2203	Gaf domain
GJE18_RS07495	COG0564	pseudouridine synthase activity
GJE18_RS07500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GJE18_RS07510	COG0114	fumarate hydratase activity
GJE18_RS07525	COG0363	glucosamine-6-phosphate deaminase activity
GJE18_RS07530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GJE18_RS07540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GJE18_RS07550	COG0765	amino acid transport
GJE18_RS07710	COG0735	belongs to the Fur family
GJE18_RS07715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GJE18_RS07720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GJE18_RS07725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GJE18_RS07730	COG4129	membrane
GJE18_RS07735	COG0069	glutamate synthase activity
GJE18_RS07745	COG3557	Belongs to the UPF0374 family
GJE18_RS07750	COG1194	a g-specific adenine glycosylase
GJE18_RS07755	COG1988	membrane-bound metal-dependent
GJE18_RS07765	COG1134	teichoic acid transport
GJE18_RS07765	COG1388	LysM domain
GJE18_RS07775	COG2137	regulation of response to DNA damage stimulus
GJE18_RS07780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GJE18_RS07790	COG0693	protein deglycase activity
GJE18_RS07800	COG0535	radical SAM domain protein
GJE18_RS07805	COG1607	acyl-coa hydrolase
GJE18_RS07810	COG2309	aminopeptidase activity
GJE18_RS07815	COG4840	Belongs to the UPF0435 family
GJE18_RS07830	COG1295	ribonuclease BN
GJE18_RS07835	COG0288	reversible hydration of carbon dioxide
GJE18_RS07870	COG4129	membrane
GJE18_RS07885	COG1528	Iron-storage protein
GJE18_RS07895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GJE18_RS07915	COG1597	lipid kinase activity
GJE18_RS07920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GJE18_RS07930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GJE18_RS07935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GJE18_RS07940	COG4851	CamS sex pheromone cAM373 precursor
GJE18_RS07945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GJE18_RS07960	COG4496	protein, YerC YecD
GJE18_RS07975	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GJE18_RS07980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GJE18_RS07985	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GJE18_RS07995	COG0077	Prephenate dehydratase
GJE18_RS08005	COG1335	isochorismatase
GJE18_RS08010	COG1227	inorganic diphosphatase activity
GJE18_RS08020	COG1012	belongs to the aldehyde dehydrogenase family
GJE18_RS08025	COG2706	6-phosphogluconolactonase activity
GJE18_RS08065	COG4876	unkown
GJE18_RS08070	COG2610	gluconate transmembrane transporter activity
GJE18_RS08075	COG1070	Carbohydrate kinase
GJE18_RS08080	COG1802	Transcriptional regulator
GJE18_RS08090	COG1131	(ABC) transporter
GJE18_RS08110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GJE18_RS08130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GJE18_RS08150	COG4512	PFAM Accessory gene regulator B
GJE18_RS08170	COG1621	beta-fructofuranosidase activity
GJE18_RS08175	COG0425	Belongs to the sulfur carrier protein TusA family
GJE18_RS08180	COG2391	methyltransferase activity
GJE18_RS08190	COG0488	(ABC) transporter
GJE18_RS08195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GJE18_RS08200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GJE18_RS08205	COG0456	acetyltransferase
GJE18_RS08210	COG1214	PFAM Peptidase M22, glycoprotease
GJE18_RS08215	COG0802	atpase or kinase
GJE18_RS08220	COG0129	dihydroxy-acid dehydratase activity
GJE18_RS08225	COG0028	Belongs to the TPP enzyme family
GJE18_RS08230	COG0440	acetolactate synthase activity
GJE18_RS08235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GJE18_RS08240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GJE18_RS08250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GJE18_RS08260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GJE18_RS08295	COG2183	response to ionizing radiation
GJE18_RS08300	COG1191	sigma factor activity
GJE18_RS08315	COG2208	phosphoserine phosphatase activity
GJE18_RS08320	COG2337	Toxic component of a toxin-antitoxin (TA) module
GJE18_RS08335	COG0736	holo-[acyl-carrier-protein] synthase activity
GJE18_RS08340	COG3402	PFAM membrane-flanked domain
GJE18_RS08355	COG0513	Belongs to the DEAD box helicase family
GJE18_RS08360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GJE18_RS08370	COG0772	Belongs to the SEDS family
GJE18_RS08375	COG2217	Heavy metal translocating P-type atpase
GJE18_RS08390	COG1937	Protein conserved in bacteria
GJE18_RS08400	COG1418	mRNA catabolic process
GJE18_RS08405	COG0706	membrane insertase activity
GJE18_RS08410	COG0352	thiamine-phosphate diphosphorylase activity
GJE18_RS08415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GJE18_RS08425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GJE18_RS08430	COG1388	LysM domain
GJE18_RS08435	COG0629	single-stranded DNA binding
GJE18_RS08445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GJE18_RS08455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GJE18_RS08475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GJE18_RS08485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GJE18_RS08495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GJE18_RS08500	COG0356	it plays a direct role in the translocation of protons across the membrane
GJE18_RS08510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GJE18_RS08515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GJE18_RS08520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GJE18_RS08525	COG4475	Protein of unknown function (DUF436)
GJE18_RS08530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GJE18_RS08535	COG0009	L-threonylcarbamoyladenylate synthase
GJE18_RS08540	COG2890	protein-(glutamine-N5) methyltransferase activity
GJE18_RS08545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GJE18_RS08555	COG0254	rRNA binding
GJE18_RS08560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GJE18_RS08565	COG1012	belongs to the aldehyde dehydrogenase family
GJE18_RS08570	COG1733	regulation of RNA biosynthetic process
GJE18_RS08575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GJE18_RS08580	COG0191	fructose-bisphosphate aldolase activity
GJE18_RS08590	COG0504	CTP synthase activity
GJE18_RS08615	COG5146	pantothenate kinase activity
GJE18_RS08635	COG1854	S-ribosylhomocysteine lyase activity
GJE18_RS08650	COG0813	purine-nucleoside phosphorylase activity
GJE18_RS08675	COG1482	cell wall glycoprotein biosynthetic process
GJE18_RS08680	COG2186	Transcriptional regulator
GJE18_RS08690	COG0561	phosphatase activity
GJE18_RS08695	COG1119	ATPase activity
GJE18_RS08705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GJE18_RS08770	COG0489	protein tyrosine kinase activity
GJE18_RS08775	COG2814	Major facilitator Superfamily
GJE18_RS08790	COG1272	protein, Hemolysin III
GJE18_RS08795	COG4284	Utp--glucose-1-phosphate uridylyltransferase
GJE18_RS08800	COG1988	membrane-bound metal-dependent
GJE18_RS08810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS08815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS08820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GJE18_RS08825	COG3457	Alanine racemase
GJE18_RS08830	COG4264	IucA IucC family
GJE18_RS08835	COG2814	Major facilitator Superfamily
GJE18_RS08840	COG4264	IucA IucC family
GJE18_RS08845	COG2814	Major facilitator Superfamily
GJE18_RS08850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GJE18_RS08855	COG0604	alcohol dehydrogenase
GJE18_RS08860	COG2723	6-phospho-beta-galactosidase activity
GJE18_RS08865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GJE18_RS08865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GJE18_RS08875	COG3684	Belongs to the aldolase LacD family
GJE18_RS08905	COG0204	Acyl-transferase
GJE18_RS08910	COG4589	Belongs to the CDS family
GJE18_RS08915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GJE18_RS08925	COG2226	methyltransferase
GJE18_RS08930	COG0789	Transcriptional regulator
GJE18_RS08950	COG0101	tRNA pseudouridine synthase activity
GJE18_RS08960	COG1122	ATPase activity
GJE18_RS08970	COG0203	ribosomal protein L17
GJE18_RS08975	COG0202	RNA polymerase activity
GJE18_RS08980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GJE18_RS08990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GJE18_RS09005	COG0201	protein transport
GJE18_RS09015	COG1841	ribosomal large subunit assembly
GJE18_RS09035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GJE18_RS09040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GJE18_RS09050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GJE18_RS09055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GJE18_RS09065	COG0255	Belongs to the universal ribosomal protein uL29 family
GJE18_RS09075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GJE18_RS09080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GJE18_RS09085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GJE18_RS09090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GJE18_RS09095	COG0089	rRNA binding
GJE18_RS09100	COG0088	Forms part of the polypeptide exit tunnel
GJE18_RS09105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GJE18_RS09115	COG2252	PERMEase
GJE18_RS09145	COG0436	Aminotransferase
GJE18_RS09150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GJE18_RS09155	COG2348	transferase activity, transferring amino-acyl groups
GJE18_RS09185	COG0746	molybdenum cofactor guanylyltransferase activity
GJE18_RS09195	COG0314	molybdopterin synthase activity
GJE18_RS09200	COG1763	Mo-molybdopterin cofactor biosynthetic process
GJE18_RS09210	COG0315	cyclic pyranopterin monophosphate synthase activity
GJE18_RS09215	COG0521	Mo-molybdopterin cofactor biosynthetic process
GJE18_RS09220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GJE18_RS09225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GJE18_RS09230	COG4149	molybdate abc transporter
GJE18_RS09235	COG0725	ABC transporter, periplasmic molybdate-binding protein
GJE18_RS09250	COG1268	BioY protein
GJE18_RS09260	COG2186	Transcriptional regulator
GJE18_RS09270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GJE18_RS09275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GJE18_RS09280	COG2832	Protein of unknown function (DUF454)
GJE18_RS09300	COG2124	cytochrome p450
GJE18_RS09315	COG5434	Belongs to the glycosyl hydrolase 28 family
GJE18_RS09340	COG3942	CHAP domain
GJE18_RS09350	COG1757	Na H antiporter
GJE18_RS09365	COG3942	CHAP domain
GJE18_RS09395	COG3383	formate dehydrogenase (NAD+) activity
GJE18_RS09400	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GJE18_RS09405	COG1316	TRANSCRIPTIONal
GJE18_RS09430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GJE18_RS09435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GJE18_RS09435	COG1263	PTS System
GJE18_RS09440	COG1113	amino acid transport
GJE18_RS09465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GJE18_RS09470	COG0346	lactoylglutathione lyase activity
GJE18_RS09480	COG0385	Bile acid
GJE18_RS09500	COG1473	amidohydrolase
GJE18_RS09505	COG1228	amidohydrolase
GJE18_RS09520	COG0583	DNA-binding transcription factor activity
GJE18_RS09530	COG1266	CAAX protease self-immunity
GJE18_RS09535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GJE18_RS09540	COG2258	MOSC domain
GJE18_RS09550	COG2017	converts alpha-aldose to the beta-anomer
GJE18_RS09555	COG1742	UPF0060 membrane protein
GJE18_RS09560	COG1668	transmembrane transport
GJE18_RS09565	COG4152	abc transporter atp-binding protein
GJE18_RS09570	COG3152	Membrane
GJE18_RS09575	COG2094	Belongs to the DNA glycosylase MPG family
GJE18_RS09580	COG1757	Na H antiporter
GJE18_RS09590	COG2207	Transcriptional regulator
GJE18_RS09595	COG0786	glutamate:sodium symporter activity
GJE18_RS09600	COG0523	cobalamin synthesis protein
GJE18_RS09605	COG1304	FMN binding
GJE18_RS09620	COG0657	acetylesterase activity
GJE18_RS09650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GJE18_RS09655	COG1136	(ABC) transporter
GJE18_RS09675	COG0579	oxidoreductase
GJE18_RS09685	COG1620	l-lactate permease
GJE18_RS09700	COG0604	alcohol dehydrogenase
GJE18_RS09705	COG2814	Major facilitator Superfamily
GJE18_RS09710	COG0492	ferredoxin-NADP+ reductase activity
GJE18_RS09730	COG1283	sodium-dependent phosphate transmembrane transporter activity
GJE18_RS09735	COG1846	Transcriptional regulator
GJE18_RS09750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GJE18_RS09755	COG2807	transmembrane transport
GJE18_RS09770	COG0697	spore germination
GJE18_RS09775	COG1363	Peptidase, m42
GJE18_RS09785	COG4187	Peptidase family M20/M25/M40
GJE18_RS09790	COG2223	nitrite transmembrane transporter activity
GJE18_RS09795	COG2197	response regulator
GJE18_RS09800	COG4585	Histidine kinase
GJE18_RS09810	COG2181	nitrate reductase activity
GJE18_RS09815	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GJE18_RS09820	COG1140	nitrate reductase beta subunit
GJE18_RS09825	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GJE18_RS09830	COG0737	Belongs to the 5'-nucleotidase family
GJE18_RS09835	COG1648	precorrin-2 dehydrogenase activity
GJE18_RS09835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GJE18_RS09840	COG2146	nitrite reductase [NAD(P)H] activity
GJE18_RS09845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GJE18_RS09860	COG0454	-acetyltransferase
GJE18_RS09865	COG2116	formate transmembrane transporter activity
GJE18_RS09875	COG0471	metal ion transport
GJE18_RS09895	COG1760	l-serine dehydratase
GJE18_RS09900	COG1760	l-serine dehydratase
GJE18_RS09915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GJE18_RS09920	COG0601	transmembrane transport
GJE18_RS09925	COG4608	Belongs to the ABC transporter superfamily
GJE18_RS09930	COG0444	Belongs to the ABC transporter superfamily
GJE18_RS09940	COG0702	epimerase
GJE18_RS09950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GJE18_RS09965	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GJE18_RS09970	COG1929	Belongs to the glycerate kinase type-1 family
GJE18_RS09975	COG3764	Sortase (surface protein transpeptidase)
GJE18_RS09980	COG2271	Major facilitator Superfamily
GJE18_RS09995	COG1115	amino acid carrier protein
GJE18_RS10000	COG3871	stress protein (general stress protein 26)
GJE18_RS10005	COG0346	lactoylglutathione lyase activity
GJE18_RS10010	COG1132	(ABC) transporter
GJE18_RS10015	COG1132	(ABC) transporter
GJE18_RS10020	COG0247	lactate metabolic process
GJE18_RS10025	COG0277	FAD linked oxidase domain protein
GJE18_RS10045	COG0159	tryptophan synthase activity
GJE18_RS10050	COG0133	tryptophan synthase activity
GJE18_RS10060	COG0134	indole-3-glycerol-phosphate synthase activity
GJE18_RS10065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GJE18_RS10070	COG0512	Glutamine amidotransferase of anthranilate synthase
GJE18_RS10075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GJE18_RS10080	COG3961	Belongs to the TPP enzyme family
GJE18_RS10085	COG3835	regulator
GJE18_RS10095	COG0494	nUDIX hydrolase
GJE18_RS10110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GJE18_RS10140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GJE18_RS10180	COG1028	Short-chain dehydrogenase reductase Sdr
GJE18_RS10210	COG1028	Short-chain dehydrogenase reductase Sdr
GJE18_RS10220	COG2814	Major facilitator Superfamily
GJE18_RS10230	COG2267	carboxylic ester hydrolase activity
GJE18_RS10255	COG2357	RelA SpoT domain protein
GJE18_RS10260	COG0778	Nitroreductase
GJE18_RS10265	COG1846	Transcriptional regulator
GJE18_RS10270	COG4607	ABC-type enterochelin transport system periplasmic component
GJE18_RS10275	COG4604	ABC transporter, ATP-binding protein
GJE18_RS10280	COG4605	iron ion homeostasis
GJE18_RS10285	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS10300	COG5505	Protein of unknown function (DUF819)
GJE18_RS10310	COG1114	Component of the transport system for branched-chain amino acids
GJE18_RS10320	COG0523	cobalamin synthesis protein
GJE18_RS10325	COG0717	Belongs to the dCTP deaminase family
GJE18_RS10340	COG0804	urea catabolic process
GJE18_RS10345	COG0832	Belongs to the urease beta subunit family
GJE18_RS10355	COG4413	Urea transporter
GJE18_RS10375	COG0745	RESPONSE REGULATOR receiver
GJE18_RS10380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GJE18_RS10385	COG0577	efflux transmembrane transporter activity
GJE18_RS10395	COG3001	Fructosamine kinase
GJE18_RS10400	COG0778	Nitroreductase
GJE18_RS10415	COG1263	PTS System
GJE18_RS10415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GJE18_RS10430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GJE18_RS10430	COG0463	Glycosyl transferase, family 2
GJE18_RS10455	COG0747	negative chemotaxis
GJE18_RS10460	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GJE18_RS10480	COG3942	CHAP domain
GJE18_RS10480	COG1705	Flagellar rod assembly protein muramidase FlgJ
GJE18_RS10495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GJE18_RS10495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GJE18_RS10495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GJE18_RS10515	COG0596	Alpha beta hydrolase
GJE18_RS10525	COG1012	belongs to the aldehyde dehydrogenase family
GJE18_RS10530	COG2824	Alkylphosphonate utilization operon protein PhnA
GJE18_RS10550	COG2376	Dihydroxyacetone kinase
GJE18_RS10555	COG2271	Major facilitator Superfamily
GJE18_RS10570	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GJE18_RS10575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GJE18_RS10585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GJE18_RS10600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GJE18_RS10605	COG0107	imidazoleglycerol-phosphate synthase activity
GJE18_RS10620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GJE18_RS10640	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GJE18_RS10645	COG1012	belongs to the aldehyde dehydrogenase family
GJE18_RS10650	COG1510	regulation of RNA biosynthetic process
GJE18_RS10675	COG1785	Belongs to the alkaline phosphatase family
GJE18_RS10680	COG1785	Belongs to the alkaline phosphatase family
GJE18_RS10690	COG0586	Pfam SNARE associated Golgi protein
GJE18_RS10710	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GJE18_RS10715	COG0745	RESPONSE REGULATOR receiver
GJE18_RS10720	COG2205	protein histidine kinase activity
GJE18_RS10740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GJE18_RS10750	COG2843	Capsule synthesis protein
GJE18_RS10775	COG4195	phage-related replication protein
GJE18_RS10795	COG0668	transmembrane transport
GJE18_RS10800	COG0477	Major facilitator Superfamily
GJE18_RS10805	COG0741	lytic transglycosylase activity
GJE18_RS10815	COG1115	amino acid carrier protein
GJE18_RS10825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GJE18_RS10830	COG2814	Major facilitator Superfamily
GJE18_RS10835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GJE18_RS10840	COG0191	fructose-bisphosphate aldolase activity
GJE18_RS10845	COG0673	inositol 2-dehydrogenase activity
GJE18_RS10850	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GJE18_RS10855	COG1082	Xylose isomerase domain protein TIM barrel
GJE18_RS10860	COG0673	inositol 2-dehydrogenase activity
GJE18_RS10865	COG3962	Belongs to the TPP enzyme family
GJE18_RS10870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GJE18_RS10880	COG1012	belongs to the aldehyde dehydrogenase family
GJE18_RS10885	COG1349	DNA-binding transcription factor activity
GJE18_RS10925	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GJE18_RS10930	COG1335	isochorismatase
GJE18_RS10935	COG2814	Major facilitator Superfamily
GJE18_RS10990	COG3588	fructose-bisphosphate aldolase
GJE18_RS11005	COG2814	Major facilitator Superfamily
GJE18_RS11035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GJE18_RS11040	COG3037	sugar-specific permease SgaT UlaA
GJE18_RS11050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GJE18_RS11055	COG3711	transcriptional antiterminator
GJE18_RS11070	COG3192	ethanolamine utilization protein
GJE18_RS11075	COG1028	Short-chain dehydrogenase reductase Sdr
GJE18_RS11085	COG1012	belongs to the aldehyde dehydrogenase family
GJE18_RS11100	COG0025	NhaP-type Na H and K H
GJE18_RS11110	COG1879	ABC-type sugar transport system periplasmic component
GJE18_RS11115	COG1172	Belongs to the binding-protein-dependent transport system permease family
GJE18_RS11120	COG1129	ABC transporter
GJE18_RS11125	COG1869	D-ribose catabolic process
GJE18_RS11130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GJE18_RS11135	COG1609	Transcriptional regulator
GJE18_RS11140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GJE18_RS11145	COG2210	Belongs to the sulfur carrier protein TusA family
GJE18_RS11150	COG1937	Protein conserved in bacteria
GJE18_RS11155	COG0730	response to heat
GJE18_RS11160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GJE18_RS11175	COG1136	(ABC) transporter
GJE18_RS11175	COG0577	efflux transmembrane transporter activity
GJE18_RS11190	COG0318	PFAM AMP-dependent synthetase and ligase
GJE18_RS11195	COG1960	acyl-CoA dehydrogenase activity
GJE18_RS11200	COG1250	3-hydroxyacyl-CoA dehydrogenase
GJE18_RS11200	COG1024	Enoyl-CoA hydratase
GJE18_RS11205	COG0183	Belongs to the thiolase family
GJE18_RS11210	COG0384	phenazine biosynthesis protein PhzF
GJE18_RS11235	COG1073	alpha beta
GJE18_RS11255	COG1620	l-lactate permease
GJE18_RS11265	COG0156	8-amino-7-oxononanoate synthase activity
GJE18_RS11270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GJE18_RS11275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GJE18_RS11310	COG1518	maintenance of DNA repeat elements
GJE18_RS11340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GJE18_RS11365	COG1136	(ABC) transporter
GJE18_RS11370	COG2205	protein histidine kinase activity
GJE18_RS11375	COG0745	RESPONSE REGULATOR receiver
GJE18_RS11380	COG5002	protein histidine kinase activity
GJE18_RS11395	COG0745	RESPONSE REGULATOR receiver
GJE18_RS11415	COG1113	amino acid transport
GJE18_RS11420	COG1755	Isoprenylcysteine carboxyl methyltransferase
GJE18_RS11425	COG0579	oxidoreductase
GJE18_RS11435	COG2814	Major facilitator Superfamily
GJE18_RS11440	COG1438	arginine binding
GJE18_RS11465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GJE18_RS11485	COG1174	glycine betaine transport
GJE18_RS11495	COG1174	glycine betaine transport
GJE18_RS11510	COG0477	Major facilitator Superfamily
GJE18_RS11550	COG0702	epimerase
GJE18_RS11600	COG2814	Major facilitator Superfamily
GJE18_RS11605	COG0813	purine-nucleoside phosphorylase activity
GJE18_RS11610	COG2188	Transcriptional regulator
GJE18_RS11625	COG2311	Membrane
GJE18_RS11630	COG0456	acetyltransferase
GJE18_RS11635	COG2188	Transcriptional regulator
GJE18_RS11640	COG2723	6-phospho-beta-galactosidase activity
GJE18_RS11645	COG3655	Transcriptional regulator
GJE18_RS11665	COG0745	RESPONSE REGULATOR receiver
GJE18_RS11670	COG2205	protein histidine kinase activity
GJE18_RS11675	COG1136	(ABC) transporter
GJE18_RS11680	COG0577	efflux transmembrane transporter activity
GJE18_RS11685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GJE18_RS11690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS11695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GJE18_RS11700	COG0803	Belongs to the bacterial solute-binding protein 9 family
GJE18_RS11700	COG3443	Belongs to the bacterial solute-binding protein 9 family
GJE18_RS11710	COG4716	Myosin-crossreactive antigen
GJE18_RS11725	COG1705	Flagellar rod assembly protein muramidase FlgJ
GJE18_RS11725	COG3942	CHAP domain
GJE18_RS11755	COG3620	sequence-specific DNA binding
GJE18_RS11820	COG1328	CTP reductase activity
GJE18_RS11825	COG0039	L-malate dehydrogenase activity
GJE18_RS11835	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GJE18_RS11850	COG1473	amidohydrolase
GJE18_RS11870	COG1028	Short-chain dehydrogenase reductase Sdr
GJE18_RS11875	COG1475	DNA binding
GJE18_RS11880	COG0019	diaminopimelate decarboxylase activity
GJE18_RS11890	COG4264	IucA IucC family
GJE18_RS11895	COG4264	IucA IucC family
GJE18_RS11900	COG2814	Major facilitator Superfamily
GJE18_RS11905	COG4264	IucA IucC family
GJE18_RS11910	COG2423	ornithine cyclodeaminase activity
GJE18_RS11920	COG0745	RESPONSE REGULATOR receiver
GJE18_RS11925	COG2205	protein histidine kinase activity
GJE18_RS11940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GJE18_RS11945	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GJE18_RS11975	COG1131	(ABC) transporter
GJE18_RS12005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GJE18_RS12010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GJE18_RS12020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GJE18_RS12030	COG4863	YycH protein
GJE18_RS12035	COG5002	protein histidine kinase activity
GJE18_RS12060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GJE18_RS12065	COG0305	Participates in initiation and elongation during chromosome replication
GJE18_RS12070	COG0359	binds to the 23S rRNA
GJE18_RS12075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GJE18_RS12080	COG4241	membrane
GJE18_RS12085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GJE18_RS12095	COG1296	Branched-chain amino acid permease (Azaleucine resistance)