locus-tag	class	description
SA58113_RS00015	COG2501	S4 domain
SA58113_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SA58113_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SA58113_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SA58113_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
SA58113_RS00120	COG4863	YycH protein
SA58113_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SA58113_RS00135	COG0737	Belongs to the 5'-nucleotidase family
SA58113_RS00170	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SA58113_RS00175	COG1353	crispr-associated protein
SA58113_RS00180	COG1421	Csm2 Type III-A
SA58113_RS00185	COG1337	RAMP superfamily
SA58113_RS00190	COG1567	CRISPR-associated RAMP protein, Csm4 family
SA58113_RS00195	COG1332	CRISPR-associated RAMP protein, Csm5 family
SA58113_RS00255	COG2226	methyltransferase
SA58113_RS00280	COG1131	(ABC) transporter
SA58113_RS00290	COG0823	Involved in the tonB-independent uptake of proteins
SA58113_RS00325	COG1473	amidohydrolase
SA58113_RS00335	COG1283	sodium-dependent phosphate transmembrane transporter activity
SA58113_RS00340	COG4716	Myosin-crossreactive antigen
SA58113_RS00345	COG0697	spore germination
SA58113_RS00360	COG1620	l-lactate permease
SA58113_RS00375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS00380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS00385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SA58113_RS00395	COG2423	ornithine cyclodeaminase activity
SA58113_RS00400	COG4264	IucA IucC family
SA58113_RS00405	COG2814	Major facilitator Superfamily
SA58113_RS00410	COG4264	IucA IucC family
SA58113_RS00415	COG4264	IucA IucC family
SA58113_RS00425	COG0019	diaminopimelate decarboxylase activity
SA58113_RS00430	COG1475	DNA binding
SA58113_RS00455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SA58113_RS00460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SA58113_RS00500	COG0813	purine-nucleoside phosphorylase activity
SA58113_RS00505	COG2814	Major facilitator Superfamily
SA58113_RS00525	COG3639	organic phosphonate transmembrane transporter activity
SA58113_RS00545	COG0737	Belongs to the 5'-nucleotidase family
SA58113_RS00555	COG1012	belongs to the aldehyde dehydrogenase family
SA58113_RS00555	COG1454	alcohol dehydrogenase
SA58113_RS00580	COG1086	Polysaccharide biosynthesis protein
SA58113_RS00590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SA58113_RS00620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SA58113_RS00630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SA58113_RS00635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SA58113_RS00645	COG2832	Protein of unknown function (DUF454)
SA58113_RS00680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SA58113_RS00685	COG1960	acyl-CoA dehydrogenase activity
SA58113_RS00690	COG5609	conserved protein (DUF2294)
SA58113_RS00715	COG3477	response to acidic pH
SA58113_RS00745	COG1309	transcriptional regulator
SA58113_RS00750	COG1114	Component of the transport system for branched-chain amino acids
SA58113_RS00755	COG1335	isochorismatase
SA58113_RS00760	COG3961	Belongs to the TPP enzyme family
SA58113_RS00785	COG1737	Transcriptional regulator
SA58113_RS00805	COG0601	transmembrane transport
SA58113_RS00810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SA58113_RS00820	COG0405	Gamma-glutamyltransferase
SA58113_RS00840	COG3842	ATPase activity
SA58113_RS00850	COG1175	transmembrane transport
SA58113_RS00855	COG3833	ABC-type maltose transport systems, permease component
SA58113_RS00860	COG0673	inositol 2-dehydrogenase activity
SA58113_RS00865	COG0673	inositol 2-dehydrogenase activity
SA58113_RS00875	COG1755	Isoprenylcysteine carboxyl methyltransferase
SA58113_RS00910	COG0584	glycerophosphoryl diester phosphodiesterase
SA58113_RS00925	COG0183	Belongs to the thiolase family
SA58113_RS00935	COG1960	acyl-CoA dehydrogenase activity
SA58113_RS00940	COG0318	PFAM AMP-dependent synthetase and ligase
SA58113_RS00960	COG0747	negative chemotaxis
SA58113_RS00965	COG3189	MarR family transcriptional regulator
SA58113_RS00985	COG1263	PTS System
SA58113_RS00985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA58113_RS00985	COG2190	(PTS) system
SA58113_RS00990	COG1957	nucleoside hydrolase
SA58113_RS01010	COG3414	Phosphotransferase system galactitol-specific IIB component
SA58113_RS01015	COG3775	system Galactitol-specific IIC component
SA58113_RS01020	COG1063	alcohol dehydrogenase
SA58113_RS01030	COG1063	alcohol dehydrogenase
SA58113_RS01040	COG1063	alcohol dehydrogenase
SA58113_RS01045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SA58113_RS01050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SA58113_RS01060	COG1063	alcohol dehydrogenase
SA58113_RS01065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SA58113_RS01095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SA58113_RS01105	COG1263	PTS System
SA58113_RS01105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA58113_RS01105	COG2190	(PTS) system
SA58113_RS01110	COG2723	6-phospho-beta-galactosidase activity
SA58113_RS01115	COG1113	amino acid transport
SA58113_RS01135	COG1609	Transcriptional regulator
SA58113_RS01150	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SA58113_RS01160	COG1131	(ABC) transporter
SA58113_RS01190	COG3942	CHAP domain
SA58113_RS01190	COG1388	LysM domain
SA58113_RS01355	COG1114	Component of the transport system for branched-chain amino acids
SA58113_RS01365	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SA58113_RS01375	COG0577	efflux transmembrane transporter activity
SA58113_RS01405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SA58113_RS01410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SA58113_RS01435	COG3314	Sporulation integral membrane protein YlbJ
SA58113_RS01455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SA58113_RS01485	COG3037	sugar-specific permease SgaT UlaA
SA58113_RS01495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SA58113_RS01525	COG2271	Major facilitator Superfamily
SA58113_RS01530	COG0346	lactoylglutathione lyase activity
SA58113_RS01535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SA58113_RS01540	COG0431	NADPH-dependent FMN reductase
SA58113_RS01555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SA58113_RS01560	COG2822	iron ion transport
SA58113_RS01570	COG0672	)-iron permease
SA58113_RS01575	COG0805	protein transport
SA58113_RS01580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SA58113_RS01590	COG1476	TRANSCRIPTIONal
SA58113_RS01600	COG1131	(ABC) transporter
SA58113_RS01630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SA58113_RS01630	COG0646	methionine synthase
SA58113_RS01635	COG0626	cystathionine gamma-synthase activity
SA58113_RS01640	COG0626	cystathionine gamma-synthase activity
SA58113_RS01650	COG1475	DNA binding
SA58113_RS01655	COG0668	transmembrane transport
SA58113_RS01660	COG4481	Protein conserved in bacteria
SA58113_RS01665	COG0012	GTP binding
SA58113_RS01770	COG1823	symporter activity
SA58113_RS01795	COG2233	PERMEase
SA58113_RS01855	COG3759	membrane
SA58113_RS02000	COG0523	cobalamin synthesis protein
SA58113_RS02025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SA58113_RS02035	COG5609	conserved protein (DUF2294)
SA58113_RS02055	COG1647	Serine aminopeptidase, S33
SA58113_RS02060	COG0733	neurotransmitter:sodium symporter activity
SA58113_RS02065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SA58113_RS02070	COG0626	cystathionine gamma-synthase activity
SA58113_RS02085	COG2011	ABC-type metal ion transport system permease component
SA58113_RS02090	COG1464	Belongs to the NlpA lipoprotein family
SA58113_RS02110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SA58113_RS02125	COG0583	DNA-binding transcription factor activity
SA58113_RS02130	COG0070	glutamate synthase
SA58113_RS02130	COG0069	glutamate synthase activity
SA58113_RS02130	COG0067	glutamate synthase
SA58113_RS02135	COG0493	'glutamate synthase
SA58113_RS02145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA58113_RS02145	COG1263	PTS System
SA58113_RS02150	COG0366	Alpha amylase catalytic
SA58113_RS02155	COG2188	Transcriptional regulator
SA58113_RS02170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SA58113_RS02200	COG1982	Orn Lys Arg decarboxylase major
SA58113_RS02210	COG3870	Protein conserved in bacteria
SA58113_RS02215	COG0470	DNA polymerase III
SA58113_RS02220	COG1774	PSP1 C-terminal conserved region
SA58113_RS02230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SA58113_RS02240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SA58113_RS02255	COG0084	hydrolase, TatD family'
SA58113_RS02260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SA58113_RS02270	COG4466	Protein conserved in bacteria
SA58113_RS02280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SA58113_RS02285	COG0251	oxidation-reduction process
SA58113_RS02295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SA58113_RS02325	COG2244	polysaccharide biosynthetic process
SA58113_RS02330	COG3956	TIGRFAM MazG family protein
SA58113_RS02335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SA58113_RS02345	COG1098	S1 RNA binding domain
SA58113_RS02360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SA58113_RS02385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SA58113_RS02475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SA58113_RS02490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SA58113_RS02500	COG3880	PFAM UvrB UvrC protein
SA58113_RS02515	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SA58113_RS02520	COG4956	integral membrane protein (PIN domain superfamily)
SA58113_RS02545	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SA58113_RS02605	COG2813	Specifically methylates the guanine in position
SA58113_RS02645	COG1473	amidohydrolase
SA58113_RS02680	COG1428	Deoxynucleoside kinase
SA58113_RS02685	COG1428	Deoxynucleoside kinase
SA58113_RS02695	COG0561	phosphatase activity
SA58113_RS02730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SA58113_RS02745	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SA58113_RS02755	COG0546	phosphoglycolate phosphatase activity
SA58113_RS02845	COG0095	Lipoate-protein ligase
SA58113_RS02850	COG0083	homoserine kinase activity
SA58113_RS02870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SA58113_RS02980	COG0667	Aldo Keto reductase
SA58113_RS02985	COG0655	NAD(P)H dehydrogenase (quinone) activity
SA58113_RS02995	COG1078	dGTPase activity
SA58113_RS03030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SA58113_RS03035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS03040	COG0546	phosphoglycolate phosphatase activity
SA58113_RS03085	COG4974	Belongs to the 'phage' integrase family
SA58113_RS03130	COG2814	Major facilitator Superfamily
SA58113_RS03150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SA58113_RS03155	COG1121	(ABC) transporter
SA58113_RS03170	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SA58113_RS03180	COG1682	transport, permease protein
SA58113_RS03185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SA58113_RS03195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SA58113_RS03200	COG1686	Belongs to the peptidase S11 family
SA58113_RS03205	COG1132	(ABC) transporter
SA58113_RS03210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SA58113_RS03220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SA58113_RS03225	COG1120	ATPase activity
SA58113_RS03230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS03235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS03240	COG2376	Dihydroxyacetone kinase
SA58113_RS03260	COG3949	Membrane
SA58113_RS03280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SA58113_RS03295	COG1136	(ABC) transporter
SA58113_RS03300	COG0577	efflux transmembrane transporter activity
SA58113_RS03305	COG1392	Phosphate transport regulator
SA58113_RS03310	COG0306	phosphate transporter
SA58113_RS03315	COG3942	CHAP domain
SA58113_RS03315	COG1388	LysM domain
SA58113_RS03325	COG4977	sequence-specific DNA binding
SA58113_RS03325	COG1917	Cupin 2, conserved barrel domain protein
SA58113_RS03355	COG0583	DNA-binding transcription factor activity
SA58113_RS03360	COG2814	Major facilitator Superfamily
SA58113_RS03365	COG2839	Protein conserved in bacteria
SA58113_RS03395	COG1611	Belongs to the LOG family
SA58113_RS03415	COG4988	ABC transporter
SA58113_RS03420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SA58113_RS03430	COG0523	cobalamin synthesis protein
SA58113_RS03435	COG4989	oxidoreductase activity
SA58113_RS03445	COG0471	metal ion transport
SA58113_RS03450	COG0415	Belongs to the DNA photolyase family
SA58113_RS03480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SA58113_RS03485	COG1349	DNA-binding transcription factor activity
SA58113_RS03490	COG1105	Belongs to the carbohydrate kinase PfkB family
SA58113_RS03495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SA58113_RS03495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SA58113_RS03495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SA58113_RS03500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SA58113_RS03505	COG1253	flavin adenine dinucleotide binding
SA58113_RS03510	COG0656	L-ascorbic acid biosynthetic process
SA58113_RS03515	COG0463	Glycosyl transferase, family 2
SA58113_RS03550	COG0720	synthase
SA58113_RS03560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SA58113_RS03560	COG0512	Glutamine amidotransferase of anthranilate synthase
SA58113_RS03565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SA58113_RS03595	COG0488	(ABC) transporter
SA58113_RS03600	COG0514	ATP-dependent DNA helicase (RecQ)
SA58113_RS03605	COG0517	IMP dehydrogenase activity
SA58113_RS03605	COG1125	glycine betaine transport
SA58113_RS03610	COG1174	glycine betaine transport
SA58113_RS03630	COG3104	oligopeptide transport
SA58113_RS03655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SA58113_RS03660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SA58113_RS03665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS03670	COG4605	iron ion homeostasis
SA58113_RS03675	COG4604	ABC transporter, ATP-binding protein
SA58113_RS03680	COG4607	ABC-type enterochelin transport system periplasmic component
SA58113_RS03735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SA58113_RS03740	COG1739	Uncharacterized protein family UPF0029
SA58113_RS03750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SA58113_RS03755	COG1040	competence protein
SA58113_RS03775	COG1388	LysM domain
SA58113_RS03775	COG3942	CHAP domain
SA58113_RS03830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SA58113_RS03900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SA58113_RS03905	COG1647	Serine aminopeptidase, S33
SA58113_RS03910	COG0557	exoribonuclease II activity
SA58113_RS04005	COG5484	DNA packaging
SA58113_RS04005	COG3728	DNA packaging
SA58113_RS04055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SA58113_RS04090	COG1278	Cold shock
SA58113_RS04130	COG0406	alpha-ribazole phosphatase activity
SA58113_RS04135	COG1279	arginine transmembrane transporter activity
SA58113_RS04160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SA58113_RS04165	COG1393	Belongs to the ArsC family
SA58113_RS04175	COG3878	Protein conserved in bacteria
SA58113_RS04180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SA58113_RS04195	COG2011	ABC-type metal ion transport system permease component
SA58113_RS04200	COG1464	Belongs to the NlpA lipoprotein family
SA58113_RS04215	COG0396	ATPase activity
SA58113_RS04220	COG0719	Fe-S assembly protein
SA58113_RS04230	COG0822	iron-sulfur transferase activity
SA58113_RS04340	COG1484	DNA-dependent DNA replication
SA58113_RS04425	COG1783	phage Terminase large subunit
SA58113_RS04550	COG0860	N-Acetylmuramoyl-L-alanine amidase
SA58113_RS04550	COG1388	LysM domain
SA58113_RS04585	COG1253	flavin adenine dinucleotide binding
SA58113_RS04595	COG1801	Protein of unknown function DUF72
SA58113_RS04600	COG0730	response to heat
SA58113_RS04615	COG4470	Protein conserved in bacteria
SA58113_RS04625	COG2445	Protein of unknown function DUF86
SA58113_RS04655	COG1696	Membrane protein involved in D-alanine export
SA58113_RS04665	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SA58113_RS04670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SA58113_RS04675	COG4837	Protein of unknown function (DUF1462)
SA58113_RS04680	COG1252	NADH dehydrogenase
SA58113_RS04690	COG0316	Belongs to the HesB IscA family
SA58113_RS04710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SA58113_RS04715	COG2056	Na+-H+ antiporter family
SA58113_RS04775	COG1098	S1 RNA binding domain
SA58113_RS04780	COG1902	pentaerythritol trinitrate reductase activity
SA58113_RS04795	COG0584	glycerophosphoryl diester phosphodiesterase
SA58113_RS04815	COG0398	Pfam SNARE associated Golgi protein
SA58113_RS04855	COG0561	phosphatase activity
SA58113_RS04880	COG1881	PFAM PEBP family protein
SA58113_RS04910	COG0601	transmembrane transport
SA58113_RS04915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SA58113_RS04920	COG0444	Belongs to the ABC transporter superfamily
SA58113_RS04925	COG4608	Belongs to the ABC transporter superfamily
SA58113_RS04930	COG4166	transmembrane transport
SA58113_RS04935	COG0601	transmembrane transport
SA58113_RS04940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SA58113_RS04945	COG0444	Belongs to the ABC transporter superfamily
SA58113_RS04950	COG4608	Belongs to the ABC transporter superfamily
SA58113_RS04955	COG4166	transmembrane transport
SA58113_RS04980	COG1164	Oligoendopeptidase f
SA58113_RS04990	COG2346	COG2346, Truncated hemoglobins
SA58113_RS04995	COG4116	CYTH
SA58113_RS05005	COG2357	RelA SpoT domain protein
SA58113_RS05015	COG0564	pseudouridine synthase activity
SA58113_RS05020	COG2239	Acts as a magnesium transporter
SA58113_RS05025	COG0569	domain protein
SA58113_RS05025	COG0475	glutathione-regulated potassium exporter activity
SA58113_RS05035	COG0628	permease
SA58113_RS05040	COG1115	amino acid carrier protein
SA58113_RS05080	COG0861	Integral membrane protein TerC family
SA58113_RS05090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SA58113_RS05095	COG0737	Belongs to the 5'-nucleotidase family
SA58113_RS05110	COG4903	ComK protein
SA58113_RS05125	COG4873	Protein conserved in bacteria
SA58113_RS05180	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SA58113_RS05190	COG2314	TM2 domain
SA58113_RS05200	COG1575	Belongs to the MenA family. Type 1 subfamily
SA58113_RS05210	COG1169	isochorismate synthase
SA58113_RS05220	COG0596	Alpha beta hydrolase
SA58113_RS05250	COG0436	Aminotransferase
SA58113_RS05255	COG3594	Acyltransferase
SA58113_RS05280	COG1316	TRANSCRIPTIONal
SA58113_RS05320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SA58113_RS05335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SA58113_RS05375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SA58113_RS05380	COG4172	Belongs to the ABC transporter superfamily
SA58113_RS05400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SA58113_RS05420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SA58113_RS05425	COG1271	oxidase subunit
SA58113_RS05430	COG1294	oxidase, subunit
SA58113_RS05435	COG0569	domain protein
SA58113_RS05495	COG1176	ABC-type spermidine putrescine transport system, permease component I
SA58113_RS05500	COG1177	transmembrane transport
SA58113_RS05505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SA58113_RS05530	COG0483	inositol monophosphate 1-phosphatase activity
SA58113_RS05540	COG1217	gtp-binding protein TYPA
SA58113_RS05550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SA58113_RS05560	COG0772	Belongs to the SEDS family
SA58113_RS05590	COG3679	Belongs to the UPF0342 family
SA58113_RS05610	COG0742	ribosomal rna small subunit methyltransferase
SA58113_RS05670	COG4509	Sortase family
SA58113_RS05680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SA58113_RS05710	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SA58113_RS05720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SA58113_RS05720	COG1796	DNA polymerase
SA58113_RS05740	COG2009	succinate dehydrogenase
SA58113_RS05745	COG1053	succinate dehydrogenase
SA58113_RS05750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SA58113_RS05845	COG1288	antiporter activity
SA58113_RS05875	COG1011	Hydrolase
SA58113_RS05900	COG4839	cell division protein FtsL
SA58113_RS05905	COG0768	penicillin binding
SA58113_RS05920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SA58113_RS05925	COG0849	cell division
SA58113_RS05940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SA58113_RS05945	COG1799	cell septum assembly
SA58113_RS05950	COG0762	integral membrane protein
SA58113_RS05960	COG3599	regulation of cell shape
SA58113_RS05980	COG0564	pseudouridine synthase activity
SA58113_RS05990	COG2233	PERMEase
SA58113_RS06035	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SA58113_RS06050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SA58113_RS06055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SA58113_RS06080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SA58113_RS06080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SA58113_RS06090	COG0631	protein serine/threonine phosphatase activity
SA58113_RS06105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SA58113_RS06120	COG1302	Protein conserved in bacteria
SA58113_RS06165	COG1196	nuclear chromosome segregation
SA58113_RS06170	COG0552	protein localization to endoplasmic reticulum
SA58113_RS06180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SA58113_RS06230	COG0758	DNA mediated transformation
SA58113_RS06325	COG0195	Participates in both transcription termination and antitermination
SA58113_RS06330	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SA58113_RS06335	COG1358	cellular component organization or biogenesis
SA58113_RS06355	COG0196	riboflavin kinase activity
SA58113_RS06385	COG2188	Transcriptional regulator
SA58113_RS06390	COG0612	Peptidase, M16
SA58113_RS06395	COG0612	Peptidase, M16
SA58113_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
SA58113_RS06420	COG1058	Belongs to the CinA family
SA58113_RS06420	COG1546	Belongs to the CinA family
SA58113_RS06445	COG1692	metallophosphoesterase
SA58113_RS06450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SA58113_RS06450	COG0674	pyruvate-flavodoxin oxidoreductase activity
SA58113_RS06455	COG1013	pyruvate-flavodoxin oxidoreductase activity
SA58113_RS06490	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SA58113_RS06495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SA58113_RS06520	COG1923	regulation of RNA biosynthetic process
SA58113_RS06530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SA58113_RS06535	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SA58113_RS06540	COG0789	Transcriptional regulator
SA58113_RS06635	COG1131	(ABC) transporter
SA58113_RS06650	COG2197	response regulator
SA58113_RS06660	COG1525	nuclease
SA58113_RS06675	COG0527	aspartate kinase activity
SA58113_RS06680	COG0460	homoserine dehydrogenase
SA58113_RS06685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SA58113_RS06710	COG0833	amino acid
SA58113_RS06740	COG2340	Cysteine-rich secretory protein family
SA58113_RS06770	COG4846	Membrane protein involved in cytochrome C biogenesis
SA58113_RS06790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SA58113_RS06800	COG0824	Thioesterase
SA58113_RS06825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SA58113_RS06835	COG1115	amino acid carrier protein
SA58113_RS06845	COG0628	permease
SA58113_RS06870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SA58113_RS06875	COG0287	Prephenate dehydrogenase
SA58113_RS06880	COG1363	Peptidase, m42
SA58113_RS06885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SA58113_RS06890	COG0512	Glutamine amidotransferase of anthranilate synthase
SA58113_RS06970	COG0704	Plays a role in the regulation of phosphate uptake
SA58113_RS06980	COG0581	inorganic phosphate transmembrane transporter activity
SA58113_RS06985	COG0573	inorganic phosphate transmembrane transporter activity
SA58113_RS07000	COG0488	(ABC) transporter
SA58113_RS07005	COG0527	aspartate kinase activity
SA58113_RS07010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SA58113_RS07085	COG4548	von Willebrand factor, type A
SA58113_RS07090	COG0714	Associated with various cellular activities
SA58113_RS07130	COG0671	phosphoesterase, PA-phosphatase related
SA58113_RS07205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SA58113_RS07225	COG0531	amino acid
SA58113_RS07240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SA58113_RS07245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SA58113_RS07260	COG0116	Belongs to the methyltransferase superfamily
SA58113_RS07295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SA58113_RS07295	COG4499	WXG100 protein secretion system (Wss), protein YukC
SA58113_RS07305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SA58113_RS07310	COG3935	DnaD domain protein
SA58113_RS07335	COG0438	transferase activity, transferring glycosyl groups
SA58113_RS07340	COG1694	Mazg nucleotide pyrophosphohydrolase
SA58113_RS07345	COG2738	Putative neutral zinc metallopeptidase
SA58113_RS07350	COG4347	Protein of unknown function (DUF1405)
SA58113_RS07390	COG0142	geranyltranstransferase activity
SA58113_RS07445	COG0492	ferredoxin-NADP+ reductase activity
SA58113_RS07455	COG0514	ATP-dependent DNA helicase (RecQ)
SA58113_RS07465	COG1141	Ferredoxin
SA58113_RS07510	COG5002	protein histidine kinase activity
SA58113_RS07515	COG0745	RESPONSE REGULATOR receiver
SA58113_RS07520	COG1187	pseudouridine synthase activity
SA58113_RS07535	COG1547	Domain of unknown function (DUF309)
SA58113_RS07545	COG0735	belongs to the Fur family
SA58113_RS07550	COG0494	nUDIX hydrolase
SA58113_RS07555	COG0667	Aldo Keto reductase
SA58113_RS07565	COG0300	oxidoreductase activity
SA58113_RS07580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SA58113_RS07590	COG0366	Alpha amylase catalytic
SA58113_RS07595	COG1609	Transcriptional regulator
SA58113_RS07610	COG2195	Cleaves the N-terminal amino acid of tripeptides
SA58113_RS07615	COG4129	membrane
SA58113_RS07625	COG0508	dehydrogenase complex catalyzes the overall conversion of
SA58113_RS07630	COG0022	dehydrogenase e1 component
SA58113_RS07635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SA58113_RS07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SA58113_RS07645	COG0497	DNA recombination
SA58113_RS07675	COG1302	Protein conserved in bacteria
SA58113_RS07680	COG0439	Biotin carboxylase
SA58113_RS07685	COG0511	ligase activity, forming carbon-carbon bonds
SA58113_RS07695	COG0006	proline dipeptidase activity
SA58113_RS07710	COG0095	Lipoate-protein ligase
SA58113_RS07715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SA58113_RS07760	COG4537	Required for transformation and DNA binding
SA58113_RS07765	COG1459	type II secretion system
SA58113_RS07770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SA58113_RS07775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SA58113_RS07780	COG0011	TIGRFAM Protein of
SA58113_RS07785	COG1940	carbohydrate kinase activity
SA58113_RS07790	COG4483	Protein conserved in bacteria
SA58113_RS07800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SA58113_RS07810	COG0768	penicillin binding
SA58113_RS07825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SA58113_RS07830	COG1121	(ABC) transporter
SA58113_RS07840	COG0513	Belongs to the DEAD box helicase family
SA58113_RS07850	COG2384	SAM-dependent methyltransferase
SA58113_RS07870	COG0517	IMP dehydrogenase activity
SA58113_RS07890	COG0295	cytidine deaminase activity
SA58113_RS07905	COG1702	phosphate starvation-inducible protein PhoH
SA58113_RS07920	COG1030	water channel activity
SA58113_RS07930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SA58113_RS07935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SA58113_RS07965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SA58113_RS07980	COG1466	dna polymerase III delta subunit
SA58113_RS07985	COG2333	competence protein COMEC
SA58113_RS07985	COG0658	competence protein
SA58113_RS07990	COG2131	deaminase
SA58113_RS08000	COG2226	methyltransferase
SA58113_RS08005	COG0799	negative regulation of ribosome biogenesis
SA58113_RS08010	COG1713	HD superfamily hydrolase involved in NAD metabolism
SA58113_RS08020	COG1534	Rna-binding protein
SA58113_RS08030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SA58113_RS08035	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SA58113_RS08050	COG3177	Filamentation induced by cAMP protein fic
SA58113_RS08060	COG1914	H( )-stimulated, divalent metal cation uptake system
SA58113_RS08070	COG0439	Biotin carboxylase
SA58113_RS08075	COG0511	ligase activity, forming carbon-carbon bonds
SA58113_RS08080	COG1984	allophanate hydrolase subunit 2
SA58113_RS08085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SA58113_RS08100	COG0826	peptidase U32
SA58113_RS08105	COG0826	peptidase U32
SA58113_RS08135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SA58113_RS08150	COG1104	cysteine desulfurase activity
SA58113_RS08155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SA58113_RS08165	COG3237	CsbD-like
SA58113_RS08170	COG1959	2 iron, 2 sulfur cluster binding
SA58113_RS08175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SA58113_RS08180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SA58113_RS08220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SA58113_RS08220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SA58113_RS08225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SA58113_RS08225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SA58113_RS08230	COG1862	Preprotein translocase
SA58113_RS08270	COG2868	ribosomal protein
SA58113_RS08315	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SA58113_RS08320	COG0285	dihydrofolate synthase activity
SA58113_RS08330	COG2818	Glycosylase
SA58113_RS08360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SA58113_RS08395	COG4112	unkown
SA58113_RS08415	COG0833	amino acid
SA58113_RS08425	COG1484	DNA-dependent DNA replication
SA58113_RS08455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SA58113_RS08455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SA58113_RS08465	COG5002	protein histidine kinase activity
SA58113_RS08470	COG0745	RESPONSE REGULATOR receiver
SA58113_RS08480	COG0372	Belongs to the citrate synthase family
SA58113_RS08485	COG1113	amino acid transport
SA58113_RS08510	COG0281	malic enzyme
SA58113_RS08520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SA58113_RS08525	COG4109	DRTGG domain
SA58113_RS08565	COG0827	DNA restriction-modification system
SA58113_RS08575	COG0730	response to heat
SA58113_RS08585	COG1104	cysteine desulfurase activity
SA58113_RS08595	COG1956	GAF domain-containing protein
SA58113_RS08610	COG0584	glycerophosphoryl diester phosphodiesterase
SA58113_RS08615	COG1764	response to oxidative stress
SA58113_RS08625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SA58113_RS08630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SA58113_RS08640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA58113_RS08640	COG1263	PTS System
SA58113_RS08645	COG0204	Acyl-transferase
SA58113_RS08650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SA58113_RS08680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SA58113_RS08685	COG0454	-acetyltransferase
SA58113_RS08700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SA58113_RS08700	COG1605	Chorismate mutase
SA58113_RS08720	COG1674	ftsk spoiiie
SA58113_RS08725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SA58113_RS08735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SA58113_RS08740	COG1363	Peptidase, m42
SA58113_RS08750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SA58113_RS08760	COG0510	thiamine kinase activity
SA58113_RS08780	COG1187	pseudouridine synthase activity
SA58113_RS08785	COG2244	polysaccharide biosynthetic process
SA58113_RS08790	COG2081	HI0933 family
SA58113_RS08810	COG2814	Major facilitator Superfamily
SA58113_RS08815	COG1242	4 iron, 4 sulfur cluster binding
SA58113_RS08820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SA58113_RS08830	COG2267	carboxylic ester hydrolase activity
SA58113_RS08865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SA58113_RS08865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SA58113_RS08890	COG4193	domain, Protein
SA58113_RS08890	COG5632	N-Acetylmuramoyl-L-alanine amidase
SA58113_RS08890	COG3266	domain, Protein
SA58113_RS08925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SA58113_RS08940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SA58113_RS08945	COG0656	L-ascorbic acid biosynthetic process
SA58113_RS08965	COG1506	peptidase
SA58113_RS09100	COG1131	(ABC) transporter
SA58113_RS09210	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SA58113_RS09240	COG1131	(ABC) transporter
SA58113_RS09245	COG0537	adenosine 5'-monophosphoramidase activity
SA58113_RS09275	COG0420	3'-5' exonuclease activity
SA58113_RS09295	COG2197	response regulator
SA58113_RS09300	COG4585	Histidine kinase
SA58113_RS09300	COG2203	Gaf domain
SA58113_RS09305	COG0564	pseudouridine synthase activity
SA58113_RS09335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SA58113_RS09340	COG1126	abc transporter atp-binding protein
SA58113_RS09345	COG0765	amino acid transport
SA58113_RS09510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SA58113_RS09515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SA58113_RS09525	COG4129	membrane
SA58113_RS09545	COG1194	a g-specific adenine glycosylase
SA58113_RS09550	COG1988	membrane-bound metal-dependent
SA58113_RS09560	COG1134	teichoic acid transport
SA58113_RS09560	COG1388	LysM domain
SA58113_RS09590	COG0535	radical SAM domain protein
SA58113_RS09595	COG1607	acyl-coa hydrolase
SA58113_RS09600	COG2309	aminopeptidase activity
SA58113_RS09620	COG1295	ribonuclease BN
SA58113_RS09625	COG2197	response regulator
SA58113_RS09720	COG4851	CamS sex pheromone cAM373 precursor
SA58113_RS09740	COG4496	protein, YerC YecD
SA58113_RS09765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SA58113_RS09775	COG0077	Prephenate dehydratase
SA58113_RS09780	COG0471	metal ion transport
SA58113_RS09790	COG1335	isochorismatase
SA58113_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
SA58113_RS09865	COG1131	(ABC) transporter
SA58113_RS09880	COG1725	Transcriptional regulator
SA58113_RS09935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SA58113_RS10025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SA58113_RS10030	COG1621	beta-fructofuranosidase activity
SA58113_RS10035	COG1609	Transcriptional regulator
SA58113_RS10040	COG0004	ammonium transporteR
SA58113_RS10045	COG0425	Belongs to the sulfur carrier protein TusA family
SA58113_RS10050	COG2391	methyltransferase activity
SA58113_RS10060	COG0488	(ABC) transporter
SA58113_RS10065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SA58113_RS10075	COG0456	acetyltransferase
SA58113_RS10080	COG1214	PFAM Peptidase M22, glycoprotease
SA58113_RS10085	COG0802	atpase or kinase
SA58113_RS10095	COG0028	Belongs to the TPP enzyme family
SA58113_RS10175	COG2183	response to ionizing radiation
SA58113_RS10180	COG1191	sigma factor activity
SA58113_RS10190	COG1366	Belongs to the anti-sigma-factor antagonist family
SA58113_RS10195	COG2208	phosphoserine phosphatase activity
SA58113_RS10230	COG3428	Bacterial PH domain
SA58113_RS10260	COG2205	protein histidine kinase activity
SA58113_RS10265	COG0745	RESPONSE REGULATOR receiver
SA58113_RS10275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SA58113_RS10285	COG0772	Belongs to the SEDS family
SA58113_RS10300	COG1937	Protein conserved in bacteria
SA58113_RS10310	COG1418	mRNA catabolic process
SA58113_RS10350	COG0629	single-stranded DNA binding
SA58113_RS10425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SA58113_RS10450	COG0009	L-threonylcarbamoyladenylate synthase
SA58113_RS10455	COG2890	protein-(glutamine-N5) methyltransferase activity
SA58113_RS10475	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SA58113_RS10515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SA58113_RS10560	COG0813	purine-nucleoside phosphorylase activity
SA58113_RS10565	COG0783	Belongs to the Dps family
SA58113_RS10585	COG1482	cell wall glycoprotein biosynthetic process
SA58113_RS10590	COG0702	epimerase
SA58113_RS10595	COG0640	Transcriptional regulator
SA58113_RS10615	COG0561	phosphatase activity
SA58113_RS10620	COG1119	ATPase activity
SA58113_RS10640	COG3711	transcriptional antiterminator
SA58113_RS10650	COG0246	Mannitol dehydrogenase
SA58113_RS10670	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SA58113_RS10725	COG0489	protein tyrosine kinase activity
SA58113_RS10730	COG2814	Major facilitator Superfamily
SA58113_RS10745	COG1272	protein, Hemolysin III
SA58113_RS10755	COG1988	membrane-bound metal-dependent
SA58113_RS10765	COG3314	Sporulation integral membrane protein YlbJ
SA58113_RS10770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS10775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA58113_RS10780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SA58113_RS10785	COG3457	Alanine racemase
SA58113_RS10790	COG4264	IucA IucC family
SA58113_RS10795	COG2814	Major facilitator Superfamily
SA58113_RS10820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SA58113_RS10830	COG2130	NADP-dependent
SA58113_RS10890	COG1404	Belongs to the peptidase S8 family
SA58113_RS10910	COG0656	L-ascorbic acid biosynthetic process
SA58113_RS10915	COG0789	Transcriptional regulator
SA58113_RS10920	COG5492	domain, Protein
SA58113_RS10925	COG2378	regulation of single-species biofilm formation
SA58113_RS10940	COG3527	Alpha-acetolactate decarboxylase
SA58113_RS10945	COG0028	Belongs to the TPP enzyme family
SA58113_RS11035	COG0201	protein transport
SA58113_RS11045	COG1841	ribosomal large subunit assembly
SA58113_RS11050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SA58113_RS11150	COG2252	PERMEase
SA58113_RS11215	COG2814	Major facilitator Superfamily
SA58113_RS11245	COG1763	Mo-molybdopterin cofactor biosynthetic process
SA58113_RS11265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SA58113_RS11270	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SA58113_RS11275	COG4149	molybdate abc transporter
SA58113_RS11280	COG0725	ABC transporter, periplasmic molybdate-binding protein
SA58113_RS11300	COG1268	BioY protein
SA58113_RS11315	COG1960	acyl-CoA dehydrogenase activity
SA58113_RS11320	COG4413	Urea transporter
SA58113_RS11390	COG1757	Na H antiporter
SA58113_RS11405	COG3942	CHAP domain
SA58113_RS11470	COG1113	amino acid transport
SA58113_RS11490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SA58113_RS11495	COG0385	Bile acid
SA58113_RS11505	COG1263	PTS System
SA58113_RS11505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA58113_RS11510	COG1737	Transcriptional regulator
SA58113_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
SA58113_RS11535	COG1473	amidohydrolase
SA58113_RS11550	COG0583	DNA-binding transcription factor activity
SA58113_RS11575	COG2258	MOSC domain
SA58113_RS11590	COG1668	transmembrane transport
SA58113_RS11595	COG4152	abc transporter atp-binding protein
SA58113_RS11600	COG3152	Membrane
SA58113_RS11615	COG0786	glutamate:sodium symporter activity
SA58113_RS11625	COG0598	Magnesium transport protein CorA
SA58113_RS11640	COG0657	acetylesterase activity
SA58113_RS11650	COG2814	Major facilitator Superfamily
SA58113_RS11655	COG1566	PFAM secretion protein HlyD family protein
SA58113_RS11665	COG2814	Major facilitator Superfamily
SA58113_RS11725	COG1131	(ABC) transporter
SA58113_RS11740	COG1620	l-lactate permease
SA58113_RS11760	COG0604	alcohol dehydrogenase
SA58113_RS11785	COG1511	domain protein
SA58113_RS11800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA58113_RS11800	COG1263	PTS System
SA58113_RS11815	COG3871	stress protein (general stress protein 26)
SA58113_RS11865	COG0789	Transcriptional regulator
SA58113_RS11885	COG2181	nitrate reductase activity
SA58113_RS11895	COG1140	nitrate reductase beta subunit
SA58113_RS11900	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SA58113_RS11910	COG2146	nitrite reductase [NAD(P)H] activity
SA58113_RS11915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SA58113_RS11925	COG0454	-acetyltransferase
SA58113_RS11930	COG2116	formate transmembrane transporter activity
SA58113_RS11945	COG3443	Belongs to the bacterial solute-binding protein 9 family
SA58113_RS11945	COG0803	Belongs to the bacterial solute-binding protein 9 family
SA58113_RS11975	COG1126	abc transporter atp-binding protein
SA58113_RS11980	COG0765	amino acid transport
SA58113_RS11985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SA58113_RS11990	COG2814	Major facilitator Superfamily
SA58113_RS12005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SA58113_RS12045	COG0156	8-amino-7-oxononanoate synthase activity
SA58113_RS12055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SA58113_RS12060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SA58113_RS12065	COG1132	(ABC) transporter
SA58113_RS12070	COG2375	cellular response to nickel ion
SA58113_RS12070	COG1132	(ABC) transporter
SA58113_RS12090	COG1929	Belongs to the glycerate kinase type-1 family
SA58113_RS12100	COG2814	Major facilitator Superfamily
SA58113_RS12115	COG1408	metallophosphoesterase
SA58113_RS12120	COG1113	amino acid transport
SA58113_RS12130	COG0531	amino acid
SA58113_RS12135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SA58113_RS12145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SA58113_RS12155	COG1174	glycine betaine transport
SA58113_RS12165	COG1174	glycine betaine transport
SA58113_RS12175	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
SA58113_RS12185	COG0531	amino acid
SA58113_RS12190	COG2272	Belongs to the type-B carboxylesterase lipase family
SA58113_RS12195	COG2814	Major facilitator Superfamily
SA58113_RS12200	COG0390	transport system, permease component
SA58113_RS12205	COG4619	ABC transporter
SA58113_RS12210	COG1363	Peptidase, m42
SA58113_RS12215	COG4808	Protein conserved in bacteria
SA58113_RS12220	COG0069	glutamate synthase activity
SA58113_RS12240	COG0444	Belongs to the ABC transporter superfamily
SA58113_RS12275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SA58113_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
SA58113_RS12285	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SA58113_RS12290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SA58113_RS12380	COG0494	nUDIX hydrolase
SA58113_RS12420	COG1846	Transcriptional regulator
SA58113_RS12455	COG1070	Carbohydrate kinase
SA58113_RS12460	COG1802	Transcriptional regulator
SA58113_RS12465	COG0789	Transcriptional regulator
SA58113_RS12470	COG2357	RelA SpoT domain protein
SA58113_RS12490	COG2271	Major facilitator Superfamily
SA58113_RS12495	COG0586	Pfam SNARE associated Golgi protein
SA58113_RS12505	COG2814	Major facilitator Superfamily
SA58113_RS12520	COG1131	(ABC) transporter
SA58113_RS12540	COG0400	carboxylic ester hydrolase activity
SA58113_RS12545	COG0346	lactoylglutathione lyase activity
SA58113_RS12550	COG1846	Transcriptional regulator
SA58113_RS12560	COG2514	catechol 2,3-dioxygenase activity
SA58113_RS12575	COG0561	phosphatase activity
SA58113_RS12580	COG1131	(ABC) transporter
SA58113_RS12590	COG3764	Sortase (surface protein transpeptidase)
SA58113_RS12615	COG1760	l-serine dehydratase
SA58113_RS12620	COG1760	l-serine dehydratase
SA58113_RS12635	COG0697	spore germination
SA58113_RS12640	COG0657	acetylesterase activity
SA58113_RS12665	COG0028	Belongs to the TPP enzyme family
SA58113_RS12680	COG0583	DNA-binding transcription factor activity
SA58113_RS12690	COG3942	CHAP domain
SA58113_RS12715	COG3425	synthase
SA58113_RS12725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SA58113_RS12750	COG2409	Drug exporters of the RND superfamily
SA58113_RS12795	COG0436	Aminotransferase
SA58113_RS12810	COG0456	acetyltransferase
SA58113_RS12870	COG0596	Alpha beta hydrolase
SA58113_RS12905	COG3001	Fructosamine kinase
SA58113_RS12910	COG0167	dihydroorotate dehydrogenase activity
SA58113_RS12960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SA58113_RS12965	COG3527	Alpha-acetolactate decarboxylase
SA58113_RS12980	COG0531	amino acid
SA58113_RS13010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SA58113_RS13030	COG1012	belongs to the aldehyde dehydrogenase family
SA58113_RS13035	COG1510	regulation of RNA biosynthetic process
SA58113_RS13045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SA58113_RS13060	COG2851	Citrate transporter
SA58113_RS13070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SA58113_RS13075	COG0386	Belongs to the glutathione peroxidase family
SA58113_RS13095	COG1136	(ABC) transporter
SA58113_RS13100	COG2205	protein histidine kinase activity
SA58113_RS13105	COG0745	RESPONSE REGULATOR receiver
SA58113_RS13130	COG1073	alpha beta
SA58113_RS13145	COG0300	oxidoreductase activity
SA58113_RS13150	COG1073	alpha beta
SA58113_RS13155	COG1785	Belongs to the alkaline phosphatase family
SA58113_RS13205	COG1438	arginine binding
SA58113_RS13225	COG3711	transcriptional antiterminator
SA58113_RS13225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SA58113_RS13230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SA58113_RS13230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SA58113_RS13230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SA58113_RS13235	COG1482	cell wall glycoprotein biosynthetic process
SA58113_RS13245	COG1705	Flagellar rod assembly protein muramidase FlgJ
SA58113_RS13245	COG3942	CHAP domain
SA58113_RS13265	COG0438	transferase activity, transferring glycosyl groups
SA58113_RS13280	COG1073	alpha beta
SA58113_RS13300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SA58113_RS13340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SA58113_RS13430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SA58113_RS13515	COG0471	metal ion transport
SA58113_RS13520	COG2962	Rard protein
SA58113_RS13530	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SA58113_RS13545	COG1136	(ABC) transporter
SA58113_RS13550	COG0577	efflux transmembrane transporter activity
SA58113_RS13560	COG1278	Cold shock
SA58113_RS13580	COG1475	DNA binding
SA58113_RS13650	COG0629	single-stranded DNA binding
SA58113_RS13685	COG3942	CHAP domain
SA58113_RS13730	COG0551	DNA topoisomerase type I activity
SA58113_RS13730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SA58113_RS13745	COG0551	DNA topoisomerase type I activity
SA58113_RS13825	COG1192	Involved in chromosome partitioning
SA58113_RS13855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SA58113_RS13940	COG1476	TRANSCRIPTIONal
SA58113_RS14195	COG1674	ftsk spoiiie